cssi/SciSciGPT-SciSciNet huggingface dataset:
Unusual presentations of gonorrhea

With the increasing incidence of gonorrhea, unusual clinical presentations of this disorder may be expected. In this report, two such cases are described. A male with primary infection of the penile skin due to gonorrhea and a female with gonorrhea-induced infection of accessory genital glands are presented. These cases illustrate the necessity to have a high index of suspicion to make the diagnosis of gonorrhea in light of atypical presenting signs or symptoms.
The FTD/ALS-associated RNA-binding protein TDP-43 regulates the robustness of neuronal specification through microRNA-9a in Drosophila

TDP-43 is an evolutionarily conserved RNA-binding protein currently under intense investigation for its involvement in the molecular pathogenesis of amyotrophic lateral sclerosis (ALS) and frontotemporal dementia (FTD). TDP-43 is normally localized in the nucleus, but translocated to the cytoplasm in diseased neurons. The endogenous functions of TDP-43 in the nervous system remain poorly understood. Here, we show that the loss of Drosophila TDP-43 (dTDP-43) results in an increased production of sensory bristles and sensory organ precursor (SOP) cells on the notum of some but not all flies. The location of ectopic SOPs varies among mutant flies. The penetrance of this novel phenotype is dependent on the gender and sensitive to environmental influences. A similar SOP phenotype was also observed on the wing and in the embryos. Overexpression of dTDP-43 causes both loss and ectopic production of SOPs. Ectopic expression of ALS-associated mutant human TDP-43 (hTDP-43(M337V) and hTDP-43(Q331K)) produces a less severe SOP phenotype than hTDP-43(WT), indicating a partial loss of function of mutant hTDP-43. In dTDP-43 mutants, miR-9a expression is significantly reduced. Genetic interaction studies further support the notion that dTDP-43 acts through miR-9a to control the precision of SOP specification. These findings reveal a novel role for endogenous TDP-43 in neuronal specification and suggest that the FTD/ALS-associated RNA-binding protein TDP-43 functions to ensure the robustness of genetic control programs.
Inner creation in knower and known, observer and observed, theorist and theorized. II. Illustrations of anti-equilibriumism or dialecticalism in psychology and sociology.

This paper is the second of a series that suggests that attitude toward equilibrium theorizing varies inversely with capacity for Rorschachian inner creation (production of Rorschach movement respo...
New Intersections for Student Engagement in Libraries: A Qualitative Exploration of Collaborative Learning with Multimedia Technologies

Objective – The purpose of this study was to explore new ways librarians can provide meaningful learning experiences for students beyond the traditional classroom assignment and the one-hour library instruction session. Methods – The study was done within a qualitative framework using participative, interpretive, and personal experience methods. The research team consisted of two librarians and a graduate student. Data collected included transcripts of audio-recorded team meetings and interviews, field notes, and a post-project survey, where students described their experiences negotiating the conceptual and technical processes of authoring a multimedia story. The instructional layer was built upon a constructivist approach allowing for a collaborative learning setting to foster learner control and self-efficacy. Results – Findings illustrate the benefits of collaborative approaches for enhancing the learning experiences of students in the library, in this case with multimedia. The data also suggest promising new ways for librarians to facilitate learning and to engage students in the library. Conclusion – Through a multimedia project that involves both librarian-guided exploration and collaborative learning processes, libraries can offer students formal and structured opportunities to explore their own interests or underlying curiosities beyond the classroom assignment and the one-hour library instruction session.
Adaptive pair-matching in randomized trials with unbiased and efficient effect estimation

In randomized trials, pair-matching is an intuitive design strategy to protect study validity and to potentially increase study power. In a common design, candidate units are identified, and their baseline characteristics used to create the best n/2 matched pairs. Within the resulting pairs, the intervention is randomized, and the outcomes measured at the end of follow-up. We consider this design to be adaptive, because the construction of the matched pairs depends on the baseline covariates of all candidate units. As a consequence, the observed data cannot be considered as n/2 independent, identically distributed pairs of units, as common practice assumes. Instead, the observed data consist of n dependent units. This paper explores the consequences of adaptive pair-matching in randomized trials for estimation of the average treatment effect, conditional the baseline covariates of the n study units. By avoiding estimation of the covariate distribution, estimators of this conditional effect will often be more precise than estimators of the marginal effect. We contrast the unadjusted estimator with targeted minimum loss based estimation and show substantial efficiency gains from matching and further gains with adjustment. This work is motivated by the Sustainable East Africa Research in Community Health study, an ongoing community randomized trial to evaluate the impact of immediate and streamlined antiretroviral therapy on HIV incidence in rural East Africa.
Microarray analysis of Foxl2 mediated gene regulation in the mouse ovary derived KK1 granulosa cell line: Over-expression of Foxl2 leads to activation of the gonadotropin releasing hormone receptor gene promoter

The Foxl2 transcription factor is required for ovarian function during follicular development. The mechanism of Foxl2 regulation of this process has not been elucidated. Our approach to begin to understand Foxl2 function is through the identification of Foxl2 regulated genes in the ovary. Transiently transfected KK1 mouse granulosa cells were used to identify genes that are potentially regulated by Foxl2. KK1 cells were transfected in three groups (mock, activated, and repressed) and twenty-four hours later RNA was isolated and submitted for Affymetrix microarray analysis. Genesifter software was used to carry out analysis of microarray data. One identified target, the gonadotropin releasing hormone receptor (GnRHR) gene, was chosen for further study and validation of Foxl2 responsiveness. Transient transfection analyses were carried out to study the effect of Foxl2 over-expression on GnRHR gene promoter-luciferase fusion activity. Data generated was analyzed with GraphPad Prism software. Microarray analysis identified 996 genes of known function that are potentially regulated by Foxl2 in mouse KK1 granulosa cells. The steroidogenic acute regulatory protein (StAR) gene that has been identified as Foxl2 responsive by others was identified in this study also, thereby supporting the effectiveness of our strategy. The GnRHR gene was chosen for further study because it is known to be expressed in the ovary and the results of previous work has indicated that Foxl2 may regulate GnRHR gene expression. Cellular levels of Foxl2 were increased via transient co-transfection of KK1 cells using a Foxl2 expression vector and a GnRHR promoter-luciferase fusion reporter vector. The results of these analyses indicate that over-expression of Foxl2 resulted in a significant increase in GnRHR promoter activity. Therefore, these transfection data validate the microarray data which suggest that Foxl2 regulates GnRHR and demonstrate that Foxl2 acts as an activator of the GnRHR gene. Potential Foxl2 regulated ovarian genes have been identified through microarray analysis and comparison of these data to other microarray studies. The Foxl2 responsiveness of the GnRHR gene has been validated and provided evidence of Foxl2 transcriptional activation of the GnRHR gene promoter in the mouse ovary derived KK1 granulosa cell line.
Prostatic-Type Epithelial Polyp of the Urethra

PROSTATIC-TYPE urethral polyps are benign polypoid to papillary structures that project into the prostatic urethra often in and around the verumontanum. 1e4 More than 200 cases have been reported, 5 including a few in the bladder. 1 Patients are typically young men 27 to 41 years old but the age range is 13 to 84 years. Most patients present with hematuria but hemospermia and dysuria have also been chief complaints. At cystourethroscopy the appearance is of small papillary or frond-like exophytic tissues or polyps that can cause concern for a neoplasm. Most polyps are small (less than 1 cm) and single but multiple polyps have been reported. Microscopic sections show delicate papillae with true fibrovascular cores lined by benign-appearing columnar prostatic epithelium with or without admixed benign urothelium (figs. 1 and 2). Benign prostatic acini are often found in the cores. The histomorphological differential diagnosis, particularly in older patients, centers on neoplastic proliferations such as papillary urothelial neoplasms, extremely rare villous adenomas and ductal adenocarcinomas of the prostate. Papillary urothelial neoplasms, including carcinoma, do not
Pseudo-Hamiltonian mechanics

Abstract : Denver Research Inst., Colo. BALLOON FLIGHT OF MARCH 16, 1961, by David G. Murcray, James N. Brooks, and Norman J. Sible. 15 Aug 61, 66p. incl. illus. (Flight data rept. no. 2) (Contract AF 33(616)7633) Unclassified report DESCRIPTORS: (*Upper atmosphere, *Infrared radiation, Measuremnt, Experimental data.) (Balloon gondolas, Balloons, Scientific re search, Instrumentation.) (Radiometers, Infra red spectroscopy, Recording devices, Power supplies, Calibration, Design.) (Liquefied gases, Nitrogen, Lead compounds, Selenides, Infrared detectors.) The results obtained on a balloon flight made with an automatic programmed radiometer system are presented. The radiometer was equipped with a liquid nitrogen cooled PbSe cell as a detectorAND MEASUREMENTS WERE MADE OF THE INFRARED BACKGROUND RADIATION FROM 1.8 TO 5.0 MICRONS. (Author)
Benzenemethanamine, α‐Phenyl‐ and Benzenemethanamine, α‐Phenyl‐, Hydrochloride

[91-00-9] C13H13N (MW 183.25) InChI = 1S/C13H13N/c14-13(11-7-3-1-4-8-11)12-9-5-2-6-10-12/h1-10,13H,14H2 InChIKey = MGHPNCMVUAKAIE-UHFFFAOYSA-N [5267-34-5] C13H14NCl (MW 219.71) InChI = 1S/C13H13N.ClH/c14-13(11-7-3-1-4-8-11)12-9-5-2-6-10-12;/h1-10,13H,14H2;1H InChIKey = CIHWJRSPVJBHGT-UHFFFAOYSA-N (serves as a stable protected amine with several methods of deprotection; can be incorporated in chiral catalysts or used in the substrate for a variety of asymmetric addition reactions) Alternate Names: benzhydrylamine, diphenylmethyl amine (DPM-amine, DPM-NH2); aminodiphenylmethane; benzhydrylamine hydrochloride. Physical Data: for [91-00-9]: bp 295 °C (flash point 113 °C), mp 12 °C, d = 1.063 g mL−1 @ 25 °C; for [5267-34-5]: mp 293–295 °C. Solubility: soluble in most organic solvents; the HCl salt is soluble in water. Form Supplied in: for [91-00-9] : colorless liquid; for [5267-34-5] : white crystalline powder; both are commercially available. Preparative Methods: phenyl Grignard addition to phenyl acetonitrile;1 exposure to HCl to form the HCl salt.7 Handling, Storage, and Precautions: harmful if inhaled or swallowed and can be irritating to the eyes, skin, and respiratory system; should be stored under an inert gas due to the hygroscopic nature; distill the amine before use.
UPPER LIMIT TO THE A$sub 2$ $Yields$ eta'$pi$ DECAY MODE.

An upper limit to the branching ratio $\frac{({A}_{2}\ensuremath{\rightarrow}{\ensuremath{\eta}}^{\ensuremath{'}}\ensuremath{\pi})}{({A}_{2}\ensuremath{\rightarrow}\ensuremath{\rho}\ensuremath{\pi})}$ is determined at the 90% confidence level to be 0.011.
Engineering method of isolation design for stand steel storage tank

Research on engineering method of isolation design for stand steel storage tank is carried out. An idea that use response spectrum method in normal design to perform seismic isolation design is put forward.
Research and Design of AVC Substation in Xin′anjiang Power Station

Based on the reactive power controlling features of Xin′anjiang Power Station,a practical design of AVC(Automatic Voltage Control) substation is proposed.After having introduced the AVC system construction,the paper presents the adaptive reactive power requirement calculation mode,the strategy of reactive dispatching in varied operating conditions and the solution for small step control catering to the special conditions of Xin′anjiang Power Station.
Comparative effects of individual amino acid excesses when added to a corn-soybean meal diet: effects on growth and dietary choice in the chick.

Six experiments were conducted with 8-d-old crossbred chicks to evaluate the effects of 4% excesses of DL-methionine (Met), L-phenylalanine (Phe), L-tryptophan (Trp), L-lysine (Lys), L-histidine (His), L-threonine (Thr), L-isoleucine (Ile), L-arginine (Arg), L-valine (Val) or L-leucine (Leu) on growth or dietary "choice" (i.e., self-selection) when added to 23% protein corn-soybean meal (C-SBM) diets. Arginine and His were supplied as the free base and Lys as Lys X acetate to avoid acid-base problems. In the growth studies, weight gain was reduced 92, 79, 53, 50, 47, 31, 29, 15, 9, 4 and 0% by additions of 4% Met, Phe, Trp, His, Lys, Tyr, Thr, Ile, Arg, Val and Leu, respectively. Improvements (P less than .05) in weight gain, feed intake and gain/feed occurred by addition of 1% Arg to the C-SBM diet supplemented with 4% excess Phe or Tyr. Addition of 1% Arg to the C-SBM diet supplemented with 4% excesses of most of the other amino acids also tended to improve performance, although diets imbalanced with Lys, Val or Leu did not respond to supplemental Arg. Self-selection studies revealed that chicks preferred the C-SBM diet containing 4% excess Lys over diets containing 4% excesses of Met, Thr, Arg or Trp. Moreover, chicks preferred diets with 4% excess Met, Thr or Arg over those containing an equal excess of Trp. When given a choice between the C-SBM diet and this diet supplemented with 4% Leu, chicks consumed similar quantities of both diets.
Spin-Josephson effects in exchange coupled antiferromagnetic insulators

The spin superfluid analogy can be extended to include Josephson-like oscillations of the spin current. In a system of two antiferromagnetic insulators (AFMIs) separated by a thin metallic spacer, a threshold spin chemical potential established perpendicular to the direction of the N\'eel vector field drives terahertz oscillations of the spin current. This spin current also has a nonlinear, time-averaged component which provides a ``smoking gun'' signature of spin superfluidity. The time-averaged spin current can be detected via the inverse spin Hall effect in a metallic spacer with large spin-orbit coupling. The physics illustrated here with AFMIs also applies to easy-plane ferromagnetic insulators. These findings may provide a new approach for experimental verification of spin superfluidity and realization of a terahertz spin oscillator.
Massive Open Online Courses (MOOCs) and the Technologies That Support Learning with Them

Methods for teaching large numbers of people over the Internet have become a popular topic as new technologies for communication and teaching large audiences have emerged in recent years. Many educational institutions are turning toward MOOCs, or massive open online courses, as a technology for delivery of learning content. In this article, we describe a brief history of MOOCs and the technologies that support learning in MOOCs. We also illustrate what uniquely defines MOOCs in comparison to other forms of distance or online learning. We conclude with a discussion on the implications for teaching and learning with MOOCs and valuable steps for MOOC design, implementation, and future research.
Source of Income Discrimination and Fair Housing Policy

The housing choice voucher program was designed with two main goals in mind: to eliminate concentrations of poverty and the social problems it causes and to provide poor households with greater access to higher-opportunity neighborhoods. However, research suggests that voucher holders would like to move to higher-opportunity neighborhoods, but often are unable to do so. One of the most prominent reasons for this is that, in most cities and states, local law allows landlords to discriminate against potential tenants on the grounds of their “source of income” (SOI). This article reviews the literature on discrimination of voucher recipients and the potential for SOI antidiscrimination laws to mitigate some of these negative outcomes.
Genetic Risk and Altering Lipids With Lifestyle Changes and Metformin: Is Fate Modifiable?

> It is not in the stars to hold our destiny but in ourselves > > —William Shakespeare The widespread availability and lower costs of genotyping and sequencing have resulted in the performance of a large number of genotype–phenotype association studies in cardiovascular medicine. The stringent requirements for correction for multiple testing and replication have particularly favored genotype–phenotype studies examining the association between genetic variation and quantitative traits that allows for greater statistical power. Multiple genome-wide association studies and a subsequent meta-analysis have identified >180 common and rare genetic variants associated with lipid traits.1,2 However, the effect size of these individual genetic variants is small, explaining only a small fraction of phenotypic variation prompting investigators to use genetic risk scores (GRS) that represent an aggregate of genetic risk to demonstrate clinical utility. Single-nucleotide polymorphisms (SNPs) and GRS have been used to predict cardiovascular disease such as coronary artery disease (CAD) and hypertension, surrogate markers of disease such as coronary calcium, cardiovascular outcomes such as myocardial infarction, and intermediate traits such as blood pressure and lipids.3 Article, see p 495 The Global Lipids Genetics Consortium has performed the largest genetic association study of lipid levels in 188 577 individuals from a total of 60 studies.1,2 There were 157 genetic loci that were identified, 95 were described previously and 62 were novel. The lipid level variance explained by the novel loci in this study ranged from 1.6% for high-density lipoprotein cholesterol (HDL-C) levels to 2.6% for total cholesterol levels. The total lipid variance explained by the previously described loci was 10% to 12%. The population studied was predominantly of European ancestry, and subjects on lipid-lowering therapy were excluded. The association of these genetic loci with lipid levels and a change in lipid levels with intervention in a prediabetic population …
EXERCISE CARDIAC POWER AND RISK OF INCIDENT HEART FAILURE

Background: We hypothesized that exercise cardiac power (ECP) defined as a ratio of directly measured maximal oxygen (VO2max) uptake with peak systolic blood pressure (SBP) during exercise has prognostic utility in heart failure (HF) risk prediction. Methods: Population-based cohort study with an
Sodium Homeostasis in Chronic Kidney Disease

The pathologic consequences of sodium retention in the CKD population can lead to hypertension, edema, and progressive disease. Sodium excess is responsible for increases in oxidative stress, which alters kidney vasculature. As progression of CKD occurs, hyperfiltration by remaining nephrons compensates for an overall decrease in the filtered load of sodium. In the later stages of CKD, compensatory mechanisms are overcome and volume overload ensues. Nephrotic syndrome as it relates to sodium handling involves a different pathophysiology despite a common phenotype. Extrarenal sodium buffering is also examined as it has significant implications in the setting of advanced CKD.
Vehicle energy consumption and an environmental impact calculation model for the transportation infrastructure systems

Abstract The interaction of vehicles and tires with various surface and structural features of roadways impact rolling resistance, hence fuel consumption of vehicles. Efficient interaction of vehicles with the roadway provides new opportunities to reduce transportation systems environmental impacts. A roughness–speed impact (RSI) model was developed to quantify the energy and environmental impacts due to vehicle–pavement interaction. The RSI model accounts for the additional rolling resistance of vehicles resulting from pavement surface properties measured in terms of smoothness as well as vehicle efficiency improvements over time. The model uses vehicle-specific power as a basis to develop the analytical equations for representing vehicle–pavement interaction. The proposed analytical model offers advantages for easy integration to LCA software to evaluate GHG reduction policies. According to the model, one unit change of IRI (63.36 in/mile) results in an average increase in fuel consumption of 3% and 2%, respectively, at high and low speeds (65 and 35 mph) for passenger cars. Heavier trucks are less sensitive to IRI change; and one unit change in IRI on average results in 2% and 1% increase, respectively, in fuel consumption of heavy truck at high and low speeds. This paper presents case studies to explore effectiveness of a short-term policy goal concerning with the management of roadway surface features. According to the LCA results with different scenarios of pavement management policies, while vehicle efficiency accounts for about 27% of the potential total energy savings, potential savings from pavement roughness can be up to 7%.
Collaborative Metadata Application Profile Development for DAMS Migration

In 2015, after an extensive review process, the University of Houston (UH) Libraries chose the open source systems Hyku (then known as the Hydra-in-a-Box project), Archivematica, and ArchivesSpace to form the Libraries’ digital collections access and preservation ecosystem. This suite of systems, along with locally developed tools, form the Bayou City Digital Asset Management System (BCDAMS). In 2016, the BCDAMS Implementation Team began work on a multi-phase process to roll out the new systems to replace the current digital collections management system, CONTENTdm. Phase I of this process included developing fundamental models and principles as well as much of the local infrastructure and workflows. Phase II of the project will involve migrating existing digital collection metadata and files to the new digital asset management system (DAMS). This poster summarizes work done during Phase I of the project to prepare for the migration work in Phase II. This included working collaboratively to develop a Metadata Application Profile (MAP) and crosswalk, and an analysis of metadata remediation required to prepare for migration. It shares the UH Libraries unique experience in preparing for the migration of UH Digital Library (UHDL) data from CONTENTdm to a new system and offers some general considerations for DAMS migrations.
Experimental study on 1/28 scaled NGNP HTGR reactor building test facility response to depressurization event

Abstract The analysis and understanding of air ingress events are an important aspect of the design of high-temperature gas-cooled reactor (HTGR) accident scenarios. These include depressurized loss of forced cooling (D-LOFC) events that allow for the possibility of air ingress into the reactor pressure vessel as a result of a break in the helium pressure boundary, which can ultimately result in oxidation of the fuel elements and other nuclear-grade graphite components. To characterize air ingress into the vented low-pressure containment of the next generation nuclear plant HTGR during hypothetical moderate-sized D-LOFC break accidents experimentally, a 1/28 scaled simplified reactor building model was established. A non-dimensional similarity approach was employed for scaling of the experimental facility. Three experiments were designed and conducted to study the dynamic response to the accident scenario. The experimental results suggest an increment in the flow area of the check valve between the reactor cavity (CV1) and steam generator cavity (CV3). Furthermore, qualitative analysis was conducted on the experimental data.
Protecting future rights for future citizens: children’s property rights in fragile environments

The property rights of children is an understudied area that straddles the development/humanitarian divide. Access to assets is important to the livelihood choices and economic well-being of adults...
Using a Bayesian Hierarchical Linear Mixing Model to Estimate Botanical Mixtures

In grazing systems, estimating the dietary choices of animals is challenging but can be achieved using plant-wax markers, natural compounds that provide a signature of individual plants. If sufficiently distinct, these signatures can be used to characterize the makeup of a botanical mixture or diet. Bayesian hierarchical models for linear unmixing (BHLU) have been widely used for hyperspectral image analysis and geochemistry, but not diet mixtures. The aim of this study was to assess the efficiency of BHLU to estimate botanical mixtures. Plant-wax marker concentrations from eight forages found in Nebraska were used for simulating combinations of two, three, five and eight species. Also, actual forage mixtures were constructed in laboratory and evaluated. Analyses were performed using BHLU with 2 prior choices for forage proportions (uniform and Gaussian), 2 covariance structures (independent and correlated markers), stable isotope mixing models (SIMM), and nonnegative least squares (NNLS). Accounting for correlations between markers increased efficiency. Estimation error increased when Gaussian priors were used to model forage proportions. Performance of BHLU, SIMM, and NNLS was reduced with the more complex botanical mixtures and the limited number of markers. For simple mixtures, BHLU is a reliable alternative to NNLS for estimation of forage proportions. Supplementary materials accompanying this paper appear online.
SMART on FHIR

A universal health app platform to support informatics-based innovations in care delivery, no matter what the underlying EMR, was a long-held dream of the academic health informatics community. In 2010, the ONC awarded $15 million to the Boston Children’s Hospital Computational Health Informatics Program and the Harvard Medical School Department of Biomedical Informatics to create and initially develop just such an app platform.
Controlling One-Seed Juniper Saplings with Small Ruminants: What We Have Learned

On the Ground • Protein supplements and polyethylene glycol increased juniper intake by small ruminants in all seasons except fall, when PSM concentrations were greatest. • Terpenes were affected by season and sapling size, and were related to juniper intake by small ruminants. • Small sapling browsing occurred most frequently in summer. Debarking of branches on taller saplings was greatest in spring. • Ten years later, juniper kill ranged from 5-14%. Growth suppression was still evident after 10 years; browsed saplings averaged 13 cm shorter than controls. • Strategies to target grazing of one-seed juniper are more likely to succeed if aligned with periods when PSM are lowest.
Broadband Full-Duplex Monostatic Circular-Antenna Arrays: Circular Arrays Reaching Simultaneous Transmit and Receive Operation

Broadband copolarized monostatic circular-antenna arrays based on mode orthogonality principles are presented for in-band full-duplex (FD) applications. The simultaneous excitation of circular phase modes in a circular array with four elements provides ideally infinite isolation. However, once the realistic beamformer network (BFN) is used, the isolation between the transmitter (Tx) and receiver (Rx) is reduced and becomes bound by the internal leakages. To mitigate the undesired leakages, two possible configurations are demonstrated: 1) a single-layer (SL) circular array excited simultaneously with mode 1 (M1) at the Tx and mixed modes at the Rx, and 2) a dual-layer (DL) circular array excited with M1 at the Tx and mode 0 (M0) at the Rx. The arrays are prototyped, in which each SL array is made of four broadband monocone antennas. A measured voltage standing wave ratio (VSWR) l2 and average isolation of 45 dB for a SL array more than at least an octave bandwidth, and 35 dB from 0.8 to 1.3 GHz and 45 dB more than 1.3 GHz for the DL array are obtained. A simple isolation enhancement layer is integrated with the shared BFN to recover from the imbalances and asymmetric leakages with an isolation improvement of up to 50 dB more than a 2.8-MHz tuneable bandwidth. The envelope correlation coefficient (ECC) is used to quantify the similarity between circular Tx/Rx array modes, and the ECC g0.6 for M1 Tx/mixed-modes Rx and g0.75 for M1 Tx/M0 Rx are achieved.
Gravity safe, electroweak natural axionic solution to strong CP and SUSY μ problems

Abstract Particle physics models with Peccei–Quinn (PQ) symmetry breaking as a consequence of supersymmetry (SUSY) breaking are attractive in that they solve the strong CP problem with a SUSY DFSZ-like axion, link the SUSY breaking and PQ breaking intermediate mass scales and can resolve the SUSY μ problem with a naturalness-required weak scale μ term whilst soft SUSY breaking terms inhabit the multi-TeV regime as required by LHC sparticle mass limits and the Higgs mass measurement. On the negative ledger, models based on global symmetries suffer a generic gravity spoliation problem. We present two models based on the discrete R-symmetry Z 24 R —which may emerge from compactification of 10-d Lorentzian spacetime in string theory—where the μ term and dangerous proton decay and R-parity violating operators are either suppressed or forbidden while a gravity-safe PQ symmetry emerges as an accidental approximate global symmetry leading to a solution to the strong CP problem and a weak-scale/natural value for the μ term.
The Virulence Function and Regulation of the Metalloprotease Gene prtA in the Plant-Pathogenic Bacterium Burkholderia glumae.

Bacterial panicle blight caused by Burkholderia glumae is a major bacterial disease of rice. Our preliminary RNA-seq study showed that a serine metalloprotease gene, prtA, is regulated in a similar manner to the genes for the biosynthesis and transport of toxoflavin, which is a known major virulence factor of B. glumae. prtA null mutants of the virulent strain B. glumae 336gr-1 did not show a detectable extracellular protease activity, indicating that prtA is the solely responsible gene for the extracellular protease activity detected from this bacterium. In addition, inoculation of rice panicles with the prtA mutants resulted in a significant reduction of disease severity compared with the wild-type parent strain, suggesting the requirement of prtA for the full virulence of B. glumae. A double mutant deficient in both serine metalloprotease and toxoflavin (ΔtoxA/prtA-) exhibited a further numeric but not statistically significant decrease of disease development compared with the ΔtoxA strain. Both the prtA-driven extracellular protease activity and the toxoflavin production were dependent on both the tofI/tofR quorum-sensing and the global regulatory gene qsmR, indicating the important roles of the two global regulatory factors for the bacterial pathogenesis by this pathogen.
Opioid Use and Intimate Partner Violence: a Systematic Review

The goal of this review was to answer two questions: A) What is the prevalence of opioid use in samples of people who are victims and/or perpetrators of intimate partner violence (IPV), and B) what is the prevalence of IPV among those who have used opioids? There were five times as many research studies of IPV in people who use opioids (B) than of opioids in IPV-experienced people (A). Across the five studies that reported estimates of opioid use among IPV-experienced people, for victimization, estimates ranged from 2.4% having an opioid use disorder (OUD) to 46–50% having had a prescription for opioid as an analgesic in the past 5 years. For perpetration, there was a sole study which found that 1.5% of a sample of perpetrators of IPV reported having an OUD. The prevalence of IPV victimization among women who had used opioids was 36–94% in their lifetimes, and 32–75% in the past year. For men who had used opioids, the prevalence of IPV perpetration ranged from 15% perpetrating severe physical IPV or a gun/knife threat in the past year to 58% reporting any IPV perpetration in their lifetimes. IPV is frequent among people who use opioids. Opioid use appears to be elevated in IPV victims and/or perpetrators as compared with the general population. Research is needed on the prevalence of opioid use in samples of IPV-experienced people, including initiation of use and how opioid use influences risk for IPV.
Impacts of integrating shared autonomous vehicles into a Peer-to-Peer ridesharing system

Abstract As public perception of sharing economy in transportation has changed, mobilephone-hailed ridesharing is gaining prominence. The key aspect of capitalizing and promoting better shared-mobility systems depends on the matching rate between the supply and demand for rides. Peer-to-peer (P2P) ridesharing systems devise higher matching rate than pure ridesharing systems by attracting more drivers. Even relaxing the spatiotemporal constraints for participants could increase the chances to be matched. However, we notice that sole P2P ridesharing systems still do not guarantee matching when the number of drivers is limited. We propose the utilization of a fleet service to cover the unmatched riders in P2P ridesharing. While it can be any type of fleet services such as taxis, Uber/Lyft, or paratransit, we explore the idea of utilizing shared autonomous vehicles as a fleet, as they can be dispatched without labor. We model an integrated system for P2P ridesharing and shared autonomous fleet vehicles (SAFVs). The proposed algorithm is designed to maximize matching ratio while optimizing the number of required SAFVs. Based on a simulated study on the northern Los Angeles, the integrated shared-mobility system is shown to have high potential to serve a high fraction of riders.
Boston Marathon Bombing and Experiences of Solidarity: The Race to Understanding

3 Introduction 4 Literature Review ,,,,,,,,,,,,,,,,,,,,,,,,.......7 Methodology 22 Findings and Discussion 24 Conclusion 51
3D-printed dissolvable inserts for efficient and customizable fabrication of NMR transceiver coils.

Abstract We describe a simplified method for improving the reproducibility of transceiver coil fabrication for nuclear magnetic resonance (NMR) through single-use templates made from 3D-printed polymer forms. The utility of dissolvable inserts for achieving performance enhanced resonators (DIAPERs) is tested herein by a comparison of RF homogeneity along the rotor axis for variable-pitch solenoids with different inter-turn spacing. Simulated B1 field profiles are compared to experimental homogeneity measurements, demonstrating the potential of this approach for making NMR coils quickly and reproducibly.
“They Merely Prescribe and I Merely Swallow”: Perceptions of Antenatal Pharmaceuticals and Nutritional Supplements Among Pregnant Women in Bamako, Mali

New international guidelines for antenatal care (ANC) will likely result in an increase in nutritional supplements and preventative medications for pregnant women in low and middle-income countries. Our objective was to understand how pregnant women in Mali perceive and experience multi-drug regimens in ANC in order to reveal factors that may influence uptake and adherence. We conducted 29 semi-structured interviews and three focus groups with 21 pregnant women in two urban ANC sites in Bamako, Mali. Interviews focused on perception of purpose of ANC pharmaceuticals (particularly iron supplements, sulfadoxine-pyrimethamine as intermittent prevention of malaria and antiretroviral therapy for HIV), beliefs regarding efficacy and risk, and understanding of dosage and regimen. Transcripts were inductively coded and analyzed using the ‘Framework’ method. Participant descriptions of medication purpose, understanding of dosing, and beliefs about risks and efficacy varied widely, revealing that many pregnant women lack complete information about their medications. While some were burdened by side effects or complex regimens, women generally held favorable attitudes toward ANC medications. Responses suggest major barriers to adherence lie in the health system, namely insufficient patient-provider communication and inconsistent prescribing practices. National health programs looking to improve maternal and child health with ANC pharmaceuticals need to place greater attention on patient counseling and consistent implementation of administration guidelines. Communication that positions pharmaceuticals as beneficial to mother and child, while presenting understandable information about purpose, dosing and potential side effects can promote uptake of multi-drug regimens and ANC services in general.
Why Do Many Consumers Prefer to Pay‐Now When They Could Pay‐Later?

Payment timing is conceptualized as a payment characteristic useful in explaining motivations to prefer payment types. Cash, debit cards, and online banking represent consumers' preferences to pay now, while credit cards and loans represent the inclination to pay later. Based on a grounded theory study, a payment‐timing model is developed to theorize consumers' choices of payment types with differences in payment timing. The model presents four motivations for payment‐timing preferences: (1) the extent of rewards salience, (2) the perception of financial stress, (3) adopting heuristics for money management, and (4) the influence of perceived financial ability. Consumers choose payment‐timing options that best suit their financial strategy to manage payments in pursuit of their consumption objectives.
Fuel and hydrogen related problems for conventional steam reforming of natural gas

Abstract This chapter discusses different aspects of the steam-reforming process of conventional natural gas for central, semicentral, and distributed hydrogen production. Commercial fuel treatment routes and the related problems are addressed as well as relevant issues associated with the natural-gas purification and conversion, the hydrogen separation/purification, and the carbon dioxide sequestration steps.
Mitochondrial Pyruvate Carrier 1 Promotes Peripheral T Cell Homeostasis through Metabolic Regulation of Thymic Development

Summary Metabolic pathways regulate T cell development and function, but many remain understudied. Recently, the mitochondrial pyruvate carrier (MPC) was identified as the transporter that mediates pyruvate entry into mitochondria, promoting pyruvate oxidation. Here we find that deleting Mpc1, an obligate MPC subunit, in the hematopoietic system results in a specific reduction in peripheral αβ T cell numbers. MPC1-deficient T cells have defective thymic development at the β-selection, intermediate single positive (ISP)-to-double-positive (DP), and positive selection steps. We find that early thymocytes deficient in MPC1 display alterations to multiple pathways involved in T cell development. This results in preferred escape of more activated T cells. Finally, mice with hematopoietic deletion of Mpc1 are more susceptible to experimental autoimmune encephalomyelitis. Altogether, our study demonstrates that pyruvate oxidation by T cell precursors is necessary for optimal αβ T cell development and that its deficiency results in reduced but activated peripheral T cell populations.
Evaluation of Cyantraniliprole, Spinetoram, and Chromobacterium subtsugae Extract in Bait for Killing and Reducing Oviposition of Rhagoletis indifferens (Diptera:Tephritidae)

Insecticides mixed in sugar-protein baits or insecticides alone have been used to control tephritid fruit flies for many years. Here, effects of cyantraniliprole, spinetoram, and the biopesticide Chromobacterium subtsugae extract in sucrose-yeast extract bait or alone on kill and oviposition of western cherry fruit fly, Rhagoletis indifferens Curran (Diptera: Tephritidae), were evaluated in the laboratory. Flies were exposed to dry insecticide bait or insecticide alone in the presence or absence of a nontoxic food strip. Spinetoram alone caused greater mortality than cyantraniliprole alone, while cyantraniliprole in bait caused mortality as high as spinetoram bait and greater mortality than cyantraniliprole alone. Chromobacterium subtsugae extract alone but not in bait caused significant mortality compared with controls, but was much less effective than cyantraniliprole and spinetoram. Spinetoram alone reduced oviposition more than cyantraniliprole alone. However, cyantraniliprole bait reduced oviposition as much or more than spinetoram alone or spinetoram bait. Cyantraniliprole and spinetoram baits caused greater mortality when a nontoxic food strip was absent than present, but there was no corresponding reduction in oviposition. Chromobacterium subtsugae extract did not significantly reduce oviposition compared with controls. Potential benefits of using cyantraniliprole baits as an additional or alternative method to using more toxic spinosyn insecticides for controlling R. indifferens warrant study.
Heaving Signals in the Isopycnal Coordinate

Dynamical processes in the ocean are directly linked to the density field. Potential temperature (temperature hereafter, unless stated explicitly) and salinity are dynamical tracers; although they can affect the dynamical processes, such effects must go through the link of density. In fact, the concept of heaving can be more rigorously defined in the density coordinate, or the isopycnal coordinate. Most importantly, for the large-scale oceanic circulation and climate problems potential density is monotonic in the vertical direction; thus, it is an ideal alternative vertical coordinate. In this chapter we explore using potential density as the Lagrangian coordinate to identify heaving signals in the world oceans.
Multidisciplinary care for rural pancreatic cancer patients: Providers’ perspectives about patients’ challenges navigating between rural healthcare settings and high-volume centers.

116Background: Multidisciplinary care from high-volume centers (HVCs) improves outcomes for patients with pancreatic cancer (PC). However, rural PC patients lack access to high-volume PC specialist...
Prekindergarten and Kindergarten Center-based Child Care and Students’ Early Schooling Outcomes:

Background/ContextIn the United States, there has been an increased trend in parents’ utilization of center-based child care. Yet, though research has examined the effects of attending prekindergar...
Structural variations in cyclopentadienyl uranium(III) iodide complexes

Eight cyclopentadienyl U(III) iodide complexes have been synthesized from UI3 and crystallographically characterized to show the variations that can occur with this ligand set and uranium in the +3...
Conservative or surgical management for that shoulder dislocation

A number of factors-including patient age and risk for recurrence-influence treatment choices. Here's a closer look at what to consider.
Bicortical Titanium Tenodesis Button With Double-Row Fixation for the Treatment of Proximal Rectus Femoris Avulsion: Review of Literature and Surgical Technique.

Abstract In adult populations, rectus femoris avulsions are reported in professional soccer and football players but are noted to be exceptionally rare. No gold standard or recommendations exist for this injury; however, in cases of avulsion at the anterior inferior iliac spine, positive outcomes appear to result from rest, immobilization, and rehabilitation. Surgery is typically reserved for cases with large retractions of bone fragments or unsuccessful nonoperative treatment. Surgical treatment methods vary from direct suture repair to single- and double-row bone suture placement and even muscle-muscle repair. We present our technique using a bicortical tenodesis button with double-row fixation for the treatment of a severely retracted rectus femoris tendon avulsion in a high-level athlete.
A Novel Methodology for Process Monitoring by Using Deep Belief Network

In recent years deep learning has been broadly used for process monitoring, fault diagnosis, pattern recognition, and image classification. In industrial systems there are many process systems that require ore advanced control technologies. Filling error control is an important but challenging problem in most production systems for a wide spectrum of liquid products. The major challenges behind this control problem include uncontrollable ambient factors, highly diversified products in modern manufacturing plants, limited budget for complex feedback control schemes, etc. To devise a low cost solution that is suitable massive replication, this paper proposes a data-driven approach for filling error control by using Just-In-Time Deep Belief Networks (JIT-DBN). The proposed method aims to construct a local DBN model based on historical data to suggest stopping time for the filling process by collectively considering the fluid viscosity, filling temperature and many other affecting factors. Based on the proposed method, a systematic framework for implementation is further devised. The proposed framework leverages the advantages of edge computing and cloud platforms to present a scalable solution with guaranteed computation efficiency and excellent adaptiveness to highly diversified products. In the validation experiments, both the proposed method and the proposed implementation framework are tested in the real-world filling production line for massive production. It is found that the proposed method can effectively reduce the mean filling errors and the filling uncertainties.
Lithic Resources, Terrain Variation and Prehistoric Site Distribution in the Kansas City Locality

Variation in the distribution of prehistoric sites within a major tributary watershed of the lower Kan sas River is seen to reflect a variety of environmental variables. These include the distribution of preferred chert resources, the contrast in drainage efficiency between the principal stream valley and the valleys of its tributaries, and the differential effects of fluvial processes on the preservation or erosion of alluvial terraces. Comparison of these variables to those throughout the Kansas City locality demonstrates their influence on the settlement patterns of the prehistoric inhabitants of that region. These data provide the basis for further comparison with other localities in the Prairie Peninsula.
Hayek for development

In this book, Easterly makes a strong case that what we learn from the history of economic development is that sustained economic growth only takes root where individuals have liberty and the freedom to remake their world. Where oppressive governments obstruct that process, no amount of expert development advice or programs delivered by experts can produce the creative energy of free peoples. And where development experts actively assist or empower regimes that take away people’s rights, woe to the people and their hopes.
Do Not Fall For It

Higher education institutions must develop specific programs to guarantee not only the access but the success of every student, reducing the failure and dropouts rates. This must be done without compromises to the quality of the final degree awarded. Countries must implement policies that provide access to education for socially and economically disadvantaged sectors; that establish and insure robust-quality assurance and monitoring processes; and that create a framework to encourage institutional diversity and innovative, equitable funding mechanisms. It is difficult to imagine a comprehensive solution, but each different country must try to find a good balance between funding, access, and quality in this complicated wrangle. A long-term, sustainable solution for the growth of the higher education sector is mandatory for the economic and social stability of any nation.