cssi/SciSciGPT-SciSciNet huggingface dataset:
Intelligent single switch wheelchair navigation

We have developed an intelligent single switch scanning interface and wheelchair navigation assistance system, called intelligent single switch wheelchair navigation (ISSWN), to improve driving safety, comfort and efficiency for individuals who rely on single switch scanning as a control method. ISSWN combines a standard powered wheelchair with a laser rangefinder, a single switch scanning interface and a computer. It provides the user with context sensitive and task specific scanning options that reduce driving effort based on an interpretation of sensor data together with user input. Trials performed by 9 able-bodied participants showed that the system significantly improved driving safety and efficiency in a navigation task by significantly reducing the number of switch presses to 43.5% of traditional single switch wheelchair navigation (p < 0.001). All participants made a significant improvement (39.1%; p < 0.001) in completion time after only two trials.
Endmill Condition Monitoring and Failure Forecasting Method for Curvilinear Cuts of Nonconstant Radii

In this paper, an endmill condition monitoring technique is presented for curvilinear cutting. This algorithm operates without the need for prior knowledge of cutting conditions, tool type, cut curvature, cut direction, or directional rate of change. This technique is based on an autoregressive-type monitoring algorithm which is used to track the tool’s condition using a tri-axial accelerometer. Accelerometer signals are monitored due to the sensors relatively low cost and since use of the sensor does not limit the machining envelope. To demonstrate repeatability, eight life tests were conducted. The technique discussed herein successfully prognosis impending fracture or meltdown due to wear in all cases, providing sufficient time to remove the tools before failure is realized. Furthermore, the algorithm produces similar trends capable of forecasting failure, regardless of tool type and cut geometry. Success is seen in all cases without requiring algorithm modifications or any prior information regarding the tool or cutting conditions.Copyright © 2007 by ASME
An assessment of along‐strike fluid and heat transport within the Barbados Ridge Accretionary Complex: Results of preliminary modeling

In this investigation, we examined the effects of the three-dimensional geometry of the Barbados Ridge accretionary complex on decollement zone fluid flow and thermal transport. Modeling results indicate that fluid preferentially escapes the decollement zone through the thin sediment layer north of the Tiburon Rise. This “drain” produces a northerly (along-strike) component of fluid flow in the vicinity of the Deep Sea Drilling Project (DSDP) and Ocean Drilling Program (ODP) transect. Depending on pore-pressure ratios on the arcward boundary of the complex, the along-strike component can reach half the magnitude of the component perpendicular to the deformation front. Thermal advection along oblique flow paths would result in significantly higher decollement temperatures at the deformation front than indicated by cross-sectional models constructed perpendicular to the deformation front.
Aripiprazole for agitation in a 13-year-old girl with neuroleptic malignant syndrome.

UNLABELLED Neuroleptic Malignant Syndrome (NMS) rarely results from atypical antipsychotic therapy. To date, no information is available on the incidence of NMS with aripiprazole, a newer neuroleptic. OBJECTIVE To examine the results of a trial of aripiprazole administered to a 13-year-old Mexican-American girl during the course of NMS. METHODS Vital signs and laboratory values obtained before and during the aripiprazole trial were compared. RESULTS Aripiprazole administration resulted in a mild increase in tachycardia and brief worsening of serum creatinine kinase level, but did not significantly affect temperature, respiratory rate, or blood pressure. CONCLUSIONS In this adolescent with NMS, aripiprazole treatment was associated with a mild worsening of symptoms.
Hip and trendy: Characterizing emerging trends on Twitter

Twitter, Facebook, and other related systems that we call social awareness streams are rapidly changing the information and communication dynamics of our society. These systems, where hundreds of millions of users share short messages in real time, expose the aggregate interests and attention of global and local communities. In particular, emerging temporal trends in these systems, especially those related to a single geographic area, are a significant and revealing source of information for, and about, a local community. This study makes two essential contributions for interpreting emerging temporal trends in these information systems. First, based on a large dataset of Twitter messages from one geographic area, we develop a taxonomy of the trends present in the data. Second, we identify important dimensions according to which trends can be categorized, as well as the key distinguishing features of trends that can be derived from their associated messages. We quantitatively examine the computed features for different categories of trends, and establish that significant differences can be detected across categories. Our study advances the understanding of trends on Twitter and other social awareness streams, which will enable powerful applications and activities, including user-driven real-time information services for local communities. © 2011 Wiley Periodicals, Inc.
MO‐D‐134‐06: A Preliminary Method Correlating Patient‐Specific Parameters with Direct Measurements to Estimate Organ Doses in CT

Purpose: In the field of Computed Tomography (CT) dosimetry, there remains a need to accurately measure organ doses. Such measurements are only meaningful if they are performed under actual clinical scanning conditions, for this purpose, a cadaver can serve as the measurement subject that most closely mimics a living patient. Organ doses were measured in 7 adult female cadaveric subjects with varying body mass indices (BMIs) and for various CT protocols. Methods: A tube placement system allowed external access to internal organs, in which optically‐stimulated luminescent dosimeters (OSLDs) were placed and used to measure dose. Dosimeter placement and location was based on organ size and distribution. In order to determine organ doses of real patients, a correlation between various patient size parameters and the measured organ doses was explored. Only measurements that could be performed on a CT image or subject‐specific parameters or data which could otherwise be obtained for an actual patient were considered for this correlation. The size parameters that were examined included: body mass index (BMI), the AP and lateral dimensions of the patient, and patient perimeter. Results: The BMIs for the 7 subjects ranged from 16.6–43.9, spanning from underweight to extreme obesity. Overall average organ doses from a CAP exam for all subjects ranged from 11.8–24.4 mGy. Generally, organ doses were shown to increase with all size parameters examined. Conclusion: For the purpose of accuracy, the estimation of patient dose in CT must be based on actual physical measurements. A complete set of direct organ dose measurements for 7 adult female cadavers has been accomplished for common CT exams with this research. It has been shown before that patient size parameters can be indicative of patient dose. This work has shown further validation of this concept.
A semi-analytical model for predicting multiple propagating axially symmetric modes in cylindrical waveguides.

Abstract A semi-analytical model for multiple mode axially symmetric wave propagation in finite solid cylindrical waveguides is presented. The model is designed as a tool for predicting and interpreting experimental signals. The model is based on a common experimental configuration and considers the excitation, propagation and reception of the ultrasonic signal in the waveguide. The Pochhammer–Chree solution for an infinite cylinder is the basis for the model. Extensions are made to enable comparison to experimental results. Comparisons with experiment are performed in the time, frequency and joint-time frequency domain for both narrow band and broad band excitation of the piezo-electric transducer.
Short-and Intermediate-Range Structural Ordering in Glassy Boron Oxide.

Ordering at short-length scales is a universal feature of the glassy state. Experiments on boron oxide and other materials indicate that ordering on mesoscopic-length scales may also be universal. The high-resolution nuclear magnetic resonance (NMR) measurements of oxygen in boron oxide glass presented here provide evidence for structural units responsible for ordering on short- and intermediate-length scales. At the molecular level, planar BO3/2 units accounted for the local ordering. Oxygen-17 NMR spectra resolved detailed features of the inclusion of these units in boroxol rings, oxygen bridging two rings, and oxygen shared between two nonring BO3/2 units. On the basis of these and corroborative boron-11 NMR and scattering results, boron oxide glass consists of domains that are rich or poor in boroxol rings; these domains are proposed to be the structural basis of intermediate-range order in glassy boron oxide.
Theoretical investigation of the design and performance of a dual energy (kV and MV) radiotherapy imager

Purpose: In modern radiotherapy treatment rooms, megavoltage (MV) portal imaging and kilovoltage (kV) cone-beam CT (CBCT) imaging are performed using various active matrix flat-panel imager (AMFPI) designs. To expand the clinical utility of MV and kV imaging, MV AMFPIs incorporating thick, segmented scintillators and, separately, kV imaging using a beam’s eye view geometry have been investigated by a number of groups. Motivated by these previous studies, it is of interest to explore to what extent it is possible to preserve the benefits of kV and MV imaging using a single AMFPI design, given the considerably different x ray energy spectra used for kV and MV imaging. In this paper, considerations for the design of such a dual energy imager are explored through examination of the performance of a variety of hypothetical AMFPIs based on x ray converters employing segmented scintillators. Methods: Contrast, noise, and contrast-to-noise ratio performances were characterized through simulation modeling of CBCT imaging, while modulation transfer function, Swank factor, and signal performance were characterized through simulation modeling of planar imaging. The simulations were based on a previously reported hybrid modeling technique (accounting for both radiation and optical effects), augmented through modeling of electronic additive noise. All designs employed BGO scintillator material with thicknesses ranging from 0.25 to 4 cm and element-to-element pitches ranging from 0.508 to 1.016 mm. A series of studies were performed under both kV and MV imaging conditions to determine the most advantageous imager configuration (involving front or rear x ray illumination and use of a mirror or black reflector), converter design (pitch and thickness), and operating mode (pitch-binning combination). Results: Under the assumptions of the present study, the most advantageous imager design was found to employ rear illumination of the converter in combination with a black reflector, incorporate a BGO converter with a 0.508 mm pitch and a 2 cm thickness, and operate at full resolution for kV imaging and 2 × 2 binning mode for MV imaging. Such a dual energy imager design should provide soft tissue visualization at low, clinically practical doses under MV conditions, while helping to preserve the high spatial resolution and high contrast offered by kV imaging. Conclusions: The authors’ theoretical investigation suggests that a dual energy imager capable of largely preserving the desirable characteristics of both kV and MV imaging is feasible. Such an imager, when coupled to a dual energy radiation source, could facilitate simplification of current treatment room imaging systems (as well as their associated quality assurance), and facilitate more precise integration of kV and MV imaging information by virtue of reduced geometric uncertainties.
Time-varying functional network information extracted from brief instances of spontaneous brain activity

Recent functional magnetic resonance imaging studies have shown that the brain is remarkably active even in the absence of overt behavior, and this activity occurs in spatial patterns that are reproducible across subjects and follow the brain’s established functional subdivision. Investigating the distribution of these spatial patterns is an active area of research with the goal of obtaining a better understanding of the neural networks underlying brain function. One intriguing aspect of spontaneous activity is an apparent nonstationarity, or variability of interaction between brain regions. It was recently proposed that spontaneous brain activity may be dominated by brief traces of activity, possibly originating from a neuronal avalanching phenomenon. Such traces may involve different subregions in a network at different times, potentially reflecting functionally relevant relationships that are not captured with conventional data analysis. To investigate this, we examined publicly available functional magnetic resonance imaging data with a dedicated analysis method and found indications that functional networks inferred from conventional correlation analysis may indeed be driven by activity at only a few critical time points. Subsequent analysis of the activity at these critical time points revealed multiple spatial patterns, each distinctly different from the established functional networks. The spatial distribution of these patterns suggests a potential functional relevance.
Observation of high electron emission yields following highly charged ion impact (up to Th75+) on surfaces.

Double differential electron emission yields following the impact of fast (3.95\ifmmode\times\else\texttimes\fi{}${10}^{7}$cm/sec)${\mathrm{Ar}}^{9,12,18+}$, ${\mathrm{Ne}}^{9+}$, ${\mathrm{Xe}}^{30,44+}$, and ${\mathrm{Th}}^{70,75+}$ ions on Cu and Au targets have been measured. The electron emission is dominated by low-energy electrons (50 eV). It is found that the total yield, which rises to about 100 electrons per ion, is a nonlinear function of the total potential energy of the incident ion (up to about 200 keV).
On the value of genealogy, materiality, and networks: a response

In response to the challenges posed by Steven Engler, Martha Finch, Mark Gardiner, Laura Harrington, Paul Johnson, and Michael Stausberg, this essay fleshes out key terms in More than Belief (2011), including genealogy, materialism, non-reductionism, and networks, showing their value in researching and theorizing about religion.
Fine-scale relief related to Late Holocene channel shifting within the floor of the upper Redondo Fan, offshore Southern California

Erosional and depositional bedforms have been imaged at outcrop scale in the upper Redondo Fan, in the San Pedro Basin of offshore Southern California in ≥600 m water depths, using an Autonomous Underwater Vehicle developed by the Monterey Bay Aquarium Research Institute. The Autonomous Underwater Vehicle is equipped with multibeam and chirp sub-bottom sonars. Sampling and photographic images using the Monterey Bay Aquarium Research Institute Remotely Operated Vehicle Tiburon provide groundtruth for the Autonomous Underwater Vehicle survey. The 0·3 m vertical and 1·5 m lateral bathymetric resolution and 0·1 m sub-bottom profile resolution provide unprecedented detail of bedform morphology and structure. Multiple channels within the Redondo Fan have been active at different times during the Late Holocene (0 to 3000 yr bp). The currently active channel extending from Redondo Canyon makes an abrupt 90° turn at the canyon mouth before resuming a south-easterly course along the east side of the Redondo Fan. This channel is floored by sand and characterized by small steps generally <1 m in relief, spaced 10 to 80 m in the down-channel direction. A broader channel complex lies along the western side of the fan valley that was last active more than 850 years ago. Two distinct trains of large scours, with widths ranging from tens to a few hundred metres and depths of 20 m, occur on the floor of the western channel complex, which has a thin mud drape. If observed in cross-section only, these large scours would probably be misidentified as the thalweg of an active channel.
Clinical Human Comparison of Expanded Polytetrafluoroethylene Barrier Membrane and Freeze-Dried Dura Mater Allografts for Guided Tissue Regeneration of Lost Periodontal Support. I. Mandibular Molar Class II Furcations

The response of mandibular Class II facial furcations to guided tissue regeneration treatment with expanded polytetrafluoroethylene barrier membrane (e-PTFE) or freeze-dried dura mater allograft (FDDMA) barriers was evaluated in 11 pairs of molars in 11 patients. Following initial preparation, full thickness flaps were raised in the area being treated, the bone and furcation defects debrided of granulomatous tissue, and the involved root surfaces mechanically and chemically prepared. By random allocation, e-PTFE or FDDMA barriers were fitted over the furcations, secured in place, and the host flap repositioned or coronally positioned. Postsurgical deplaquing was performed every 10 days leading up to e-PTFE removal at about 6 weeks (the resorbable FDDMA did not require removal). Continuing supportive periodontal therapy was provided until surgical re-entry at one year for documentation and any further necessary treatment. Direct clinical measurements demonstrated essentially similar clinical results with b...
Finite difference solutions of the heat equation in a molten polymer flowing in a circular tube

We present the mathematical equations that govern heat transfer in a polymer melt flowing in a circular tube with constant ambient temperature, taking into account the viscous dissipation effects. This leads to a nonlinear parabolic partial differential equation. It is shown that the exact solution of a linearized version of the governing equation can be presented in terms of the Whittaker function. A finite difference scheme is used to produce an approximate solution of the linearized problem. This numerical solution is shown to be a good approximation to the exact solution found in terms of the Whittaker function. The finite difference scheme is then modified to approximate the nonlinear parabolic partial differential equation and is compared with the results found using the finite element method. © 2006 Wiley Periodicals, Inc. J Appl Polym Sci 102: 289–294, 2006
The comparative effects of methohexital, propofol, and etomidate for electroconvulsive therapy.

The intravenous anesthetics which are commonly used for electroconvulsive therapy (ECT) possess dose-dependent anticonvulsant properties. Since the clinical efficacy of ECT depends on the induction of a seizure of adequate duration, it is important to determine the optimal dose of the hypnotic for use during ECT. We compared the duration of seizure activity and cognitive recovery profiles after different doses of methohexital, propofol, and etomidate administered to induce hypnosis prior to ECT. Ten outpatients with major depressive disorders receiving maintenance ECT participated in this prospective, randomized, cross-over study. Patients were premedicated with glycopyrrolate, 0.2 mg intravenously (i.v.), and labetalol, 20-30 mg i.v., and hypnosis was induced with an i.v. bolus injection of methohexital or propofol (0.75, 1.0, and 1.5 mg/kg), or etomidate (0.15, 0.2, and 0.3 mg/kg), administered over 10-15 s. Adequate muscle paralysis was achieved with succinylcholine, 1.0-1.4 mg/kg i.v. Each patient's seizure threshold was determined prior to enrollment in the study and the electrical stimulus variables were kept constant throughout the study period. After delivery of a bilateral electrical stimulus, the duration of the resulting electroencephalographic (EEG) and motor seizures were recorded. A total of 90 ECT treatments were evaluated. The durations of EEG and motor seizures were longest after etomidate and shortest after propofol. There were no significant dose-related differences in motor and EEG seizure durations (means +/- SD) after the low, intermediate, and high doses of etomidate of 44 +/- 11 and 77 +/- 19, 43 +/- 10 and 76 +/- 34, 42 +/- 16 and 78 +/- 56 s, respectively. Conversely, both methohexital and propofol, 0.75, 1.0, and 1.5 mg/kg, produced dose-dependent decreases in motor and EEG seizure durations (i.e., 37 +/- 10 and 58 +/- 12, 36 +/- 8 and 62 +/- 24, and 29 +/- 13 and 48 +/- 20 for methohexital; 34 +/- 15 and 56 +/- 29, 31 +/- 8 and 50 +/- 17, and 20 +/- 6 and 33 +/- 12 for propofol, respectively). The awakening times were similar, regardless of the hypnotic or dose administered.(ABSTRACT TRUNCATED AT 250 WORDS)
Context and process: An ecological view of the interdependence of practice and research: An invited address by James G. Kelly

James G. Kelly has made important and wide-ranging conributions to community psychology. The field is fortunate to have a member with his vision and commitment. In the paper presented here, Jim discusses the advantages that arise when scientists and citizens work as collaborative partners in community research. As with his previous work, his ideas provide new insights into the role of community psychology in and for the community.
Nuclear data sheets for A = 67

Abstract Nuclear structure data available through July 1975 are compiled, and adopted level properties are given. The bulk of the data are presented pictorially for easy comparison. Experimental details, references, and additional comments, where required, are given in the text. All drawings, tables, and comments are reproduced from the computerized Evaluated Nuclear Structure Data File (ENSDF). Any additions or corrections desired by the users should be addressed to the compilers for maintenance and updating of the computer file.
Reconstitution of Uracil DNA Glycosylase-initiated Base Excision Repair in Herpes Simplex Virus-1

Herpes simplex virus-1 is a large double-stranded DNA virus that is self-sufficient in a number of genome transactions. Hence, the virus encodes its own DNA replication apparatus and is capable of mediating recombination reactions. We recently reported that the catalytic subunit of the HSV-1 DNA polymerase (UL30) exhibits apurinic/apyrimidinic and 5′-deoxyribose phosphate lyase activities that are integral to base excision repair. Base excision repair is required to maintain genome stability as a means to counter the accumulation of unusual bases and to protect from the loss of DNA bases. Here we have reconstituted a system with purified HSV-1 and human proteins that perform all the steps of uracil DNA glycosylase-initiated base excision repair. In this system nucleotide incorporation is dependent on the HSV-1 uracil DNA glycosylase (UL2), human AP endonuclease, and the HSV-1 DNA polymerase. Completion of base excision repair can be mediated by T4 DNA ligase as well as human DNA ligase I or ligase IIIα-XRCC1 complex. Of these, ligase IIIα-XRCC1 is the most efficient. Moreover, ligase IIIα-XRCC1 confers specificity onto the reaction in as much as it allows ligation to occur in the presence of the HSV-1 DNA polymerase processivity factor (UL42) and prevents base excision repair from occurring with heterologous DNA polymerases. Completion of base excision repair in this system is also dependent on the incorporation of the correct nucleotide. These findings demonstrate that the HSV-1 proteins in combination with cellular factors that are not encoded by the virus are capable of performing base excision repair. These results have implications on the role of base excision repair in viral genome maintenance during lytic replication and reactivation from latency.
Adrenergic receptors in the nucleus tractus solitarii of the rat

The nucleus tractus solitarii (NTS) is an area of the medulla in which baroreceptor afferent fibers mediating an inhibition of vasoconstriction terminate. The NTS also appears to be a site at which alpha-adrenergic receptors may be involved in blood pressure control. alpha- and beta-adrenergic agonists and antagonists were injected into the NTS via stainless steel cannulae and the effects on blood pressure determined. Norepinephrine (NE) and isoproterenol (ISO) caused dose-related decreases in mean arterial blood pressure (MABP). Phentolamine (PH) and propranolol (PR) caused dose-related increases in MABP. PH pretreatment in the NTS blocked the effects of ISO, but not NE. The effect of increased baroreceptor impulses to the NTS, produced by altering perfusion of the carotid sinus was blocked by propranolol. These results indicate the presence of beta- as well as alpha-receptors in the NTS, and also suggest the existence of presynaptic beta-receptors which facilitate neurotransmission.
The security dilemma and ethnic conflict: Some new hypotheses

(2000). The security dilemma and ethnic conflict: Some new hypotheses. Security Studies: Vol. 9, No. 4, pp. 1-51.
Surface-enhanced Raman nanodomes.

We demonstrate a surface-enhanced Raman scattering (SERS) substrate consisting of a closely spaced metal nanodome array fabricated on flexible plastic film. We used a low-cost, large-area replica molding process to produce a two-dimensional periodic array of cylinders that is subsequently overcoated with SiO2 and silver thin films to form dome-shaped structures. Finite element modeling was used to investigate the electromagnetic field distribution of the nanodome array structure and the effect of the nanodome separation distance on the electromagnetic field enhancement. The SERS enhancement from the nanodome array substrates was experimentally verified using rhodamine 6G as the analyte. With a separation distance of 17 nm achieved between adjacent domes using a process that is precisely controlled during thin film deposition, a reproducible SERS enhancement factor of 1.37 × 108 was demonstrated. The nanoreplica molding process presented in this work allows for simple, low-cost, high-throughput fabrication of uniform nanoscale SERS substrates over large surface areas without the requirement for high resolution lithography or defect-free deposition of spherical microparticle monolayer templates.
SEASONAL PRODUCTIVITY OF TWO RED ALGAE IN A CENTRAL CALIFORNIA KELP FOREST1

The in situ productivity of Botryocladia pseudodichotoma (Farl.) Kyl. and Rhodymenia californica var. californica Kyl., two common understory macrophytes in Macrocystis pyrifera (L.) C. Ag. forests, was determined once per month for one year. Gross productivity for B. pseudodichotoma was highest in October (1.23 mgC · g dry wt.−1· h−1), but rates were generally greater in spring and lower in summer. Respiration was variable throughout the year, especially in proportion to gross productivity. Gross productivity for R. californica var. californica was also highest in October (4.62 mgC · g dry wt.−1· h−1), and lowest in summer. Respiration was highly variable throughout the year. Deep (11 m) populations o/B. pseudodichotoma had 50% higher productivity than shallow (3 m) populations when incubated in shallow water, and 45% higher productivity when incubated in deep water. Populations of B. pseudodichotoma growing in shade at 3 m had 77% higher productivity than populations growing in sun at the same depth when incubated in a sun exposed location at 3 m. Respiration of the shade-adapted plants was only one-half that of the sun-adapted plants. In comparison with similar studies in other sub-tidal communities, net productivity of these two understory red algae is somewhat lower. Lack of strong seasonal productivity patterns and the highly variable underwater light regime suggests that understory algae may be adapted for rapid growth during short periods of high light, regardless of the time of year.
P163: Patients for patient safety: translating anecdote to evidence base

Capturing the “patient experience” in a manner that supports healthcare in providing quality care in a consistent manner while also effecting necessary change, continues to be a challenge for patients and patient organisations. The patient experience is often described as “the patient story” – an expression which, in itself, can sometimes detract from the perceived value of what is being offered as an accurate representation of the reality in relation to how care is actually delivered. Particularly in the area of education, the articulation of these experiences by “real people”, patients and family members, elevates the “story” to being an effective learning tool. This supports the didactic course material and promotes sustainable culture change to provide care that is truly patient-centred, especially in the areas of communication and adherence to guidance and protocols.
What Have We Learned about the Performance of Council‐Manager Government? A Review and Synthesis of the Research

The 100th anniversary of the International City/County Management Association provides an excellent point to review and assess research on the performance of the council-manager form of government.  e development of the council-manager form arguably has been the most important innovation in American local government over the last century, yet its impact on the performance of municipal governments is not well understood.  is article reviews and assesses the empirical evidence for 10 propositions that council-manager governments perform better than mayor-council governments.  is evidence indicates that although progress has been made on demonstrating diﬀ erences in representation and functionality, the proposition that council-manager governments are better managed than mayor-council governments has yet to be seriously engaged in this literature. Filling this critical gap requires progress in two areas: the development of theory to explain why council-manager governments are better-managed organizations and the production of evidence assessing the major propositions of this theory.
Antimicrobial Susceptibility to Azithromycin among Salmonella enterica Isolates from the United States

Due to emerging resistance to traditional antimicrobial agents, such as ampicillin, trimethoprim-sulfamethoxazole, and chloramphenicol, azithromycin is increasingly used for the treatment of invasive Salmonella infections. In the present study, 696 isolates of non-Typhi Salmonella collected from humans, food animals, and retail meats in the United States were investigated for antimicrobial susceptibility to azithromycin. Seventy-two Salmonella enterica serotype Typhi isolates from humans were also tested. For each isolate, MICs of azithromycin and 15 other antimicrobial agents were determined by broth microdilution. Among the non-Typhi Salmonella isolates, azithromycin MICs among human isolates ranged from 1 to 32 μg/ml, whereas the MICs among the animal and retail meat isolates ranged from 2 to 16 μg/ml and 4 to 16 μg/ml, respectively. Among Salmonella serotype Typhi isolates, the azithromycin MICs ranged from 4 to 16 μg/ml. The highest MIC observed in the present study was 32 μg/ml, and it was detected in three human isolates belonging to serotypes Kentucky, Montevideo, and Paratyphi A. Based on our findings, we propose an epidemiological cutoff value (ECOFF) for wild-type Salmonella of ≤16 μg/ml of azithromycin. The susceptibility data provided could be used in combination with clinical outcome data to determine tentative clinical breakpoints for azithromycin and Salmonella enterica.
A 1.25–5 GHz Clock Generator With High-Bandwidth Supply-Rejection Using a Regulated-Replica Regulator in 45-nm CMOS

A clock generator for high-speed chip-to-chip link receivers was implemented in a 45-nm CMOS SOI technology. A low sensitivity to supply voltage noise was achieved by means of a low dropout voltage regulator using a replica feedback in the regulation loop, where the replica resistance is regulated by a second loop. We show that by adjusting the replica load the necessary matching of the gm/gds ratio of the current sources can be achieved. A power supply rejection of > 22 dB was measured up to 1 GHz for a circuit operating from a 1 V supply with 80 pF decoupling capacitance and a load current of 18.5 mA. The maximum supply sensitivity of the clock generation circuit (DLL plus phase rotators) was 4.5 ps/100 mV supply noise over the entire noise frequency range at clock frequencies from 1.25-5 GHz. The phase rotator achieves a wide range of operating frequencies by providing programmable rise/fall times in its selection stage. In addition, low voltage operation of the circuit was demonstrated at supply voltages down to 0.7 V and a clock frequency of 1.6 GHz.
Invasion, competitive dominance, and resource use by exotic and native California grassland species

The dynamics of invasive species may depend on their abilities to compete for resources and exploit disturbances relative to the abilities of native species. We test this hypothesis and explore its implications for the restoration of native ecosystems in one of the most dramatic ecological invasions worldwide, the replacement of native perennial grasses by exotic annual grasses and forbs in 9.2 million hectares of California grasslands. The long-term persistence of these exotic annuals has been thought to imply that the exotics are superior competitors. However, seed-addition experiments in a southern California grassland revealed that native perennial species, which had lower requirements for deep soil water, soil nitrate, and light, were strong competitors, and they markedly depressed the abundance and fecundity of exotic annuals after overcoming recruitment limitations. Native species reinvaded exotic grasslands across experimentally imposed nitrogen, water, and disturbance gradients. Thus, exotic annuals are not superior competitors but rather may dominate because of prior disturbance and the low dispersal abilities and extreme current rarity of native perennials. If our results prove to be general, it may be feasible to restore native California grassland flora to at least parts of its former range.
Insertion of discrete phonological units: An articulatory and acoustic investigation of aphasic speech

The traditional view that sound structure is mentally represented by discrete phonological units has been questioned in recent years. Much of the criticism revolves around the necessity of positing gradient or continuous sound structure representations to account for certain phenomena. This paper presents evidence in favour of discrete sound structure units in addition to gradient representations. We present a case study of aphasic speaker VBR, whose spoken language production errors include vowel insertions in many word-initial consonant clusters (e.g., bleed → []). An acoustic and articulatory study is reported comparing the inserted vowels with lexical vowels in similar phonological contexts (e.g., b e lieve). The results indicate that these two vowels come from the same population, suggesting discrete insertion of a unit the same size as those used to represent lexical contrast. The implications of these data for theories of sound structure representation are discussed.
Stringent response processes suppress DNA damage sensitivity caused by deficiency in full‐length translation initiation factor 2 or PriA helicase

Summary When Escherichia coli grows in the presence of DNA-damaging agents such as methyl methanesulphonate (MMS), absence of the full-length form of Translation Initiation Factor 2 (IF2-1) or deficiency in helicase activity of replication restart protein PriA leads to a considerable loss of viability. MMS sensitivity of these mutants was contingent on the stringent response alarmone (p)ppGpp being at low levels. While zero levels (ppGpp0) greatly aggravated sensitivity, high levels promoted resistance. Moreover, M+ mutations, which suppress amino acid auxotrophy of ppGpp0 strains and which have been found to map to RNA polymerase subunits, largely restored resistance to IF2-1- and PriA helicase-deficient mutants. The truncated forms IF2-2/3 played a key part in inducing especially severe negative effects in ppGpp0 cells when restart function priB was knocked out, causing loss of viability and severe cell filamentation, indicative of SOS induction. Even a strain with the wild-type infB allele exhibited significant filamentation and MMS sensitivity in this background whereas mutations that prevent expression of IF2-2/3 essentially eliminated filamentation and largely restored MMS resistance. The results suggest different influences of IF2-1 and IF2-2/3 on the replication restart system depending on (p)ppGpp levels, each having the capacity to maximize survival under differing growth conditions.
Packaging of copper/low-k IC devices: a novel direct fine pitch gold wirebond ball interconnects onto copper/low-k terminal pads

The trend toward finer pitch and higher performance devices has driven the semiconductor industry to incorporate copper and low-k dielectric materials. Compared to the commonly used aluminum metallization scheme on the traditional silicon dioxide and/or silicon nitride passivation, a Cu/low-k combination offers higher on-chip communication speed and a lower overall device cost. However, the process of packaging Cu/low-k devices has been proven to be difficult, relying either on additional lithography and deposition steps or on costly new process tools. Thus, this paper presents a novel methodology to bond fine pitch Au wire directly onto the Cu/low-k pad structure using the industry standard tool set. A Cu/low-k test vehicle is designed with the required slotted low-k fillings for dual damascene chemical mechanical polishing (CMP) process need. In addition, a thin organic passivation film is developed for coating the exposed Cu/low-k pad temporarily from copper oxidation and to provide a wirebondable surface to form the proper interconnects. A design of experiment is performed to optimize wirebonding parameters [power, time, and ultrasonic gauge (USG) bleed], along with key physical contributors from wafer sawing and die attaching steps that impact the interconnect shear strength and quality. In addition, electrical and optical characterization and surface failure analysis are performed to confirm the feasibility of the technology. Finally, reliability results of the pad structure design and recommendations for further process optimization are presented.
Graduate Training in Sociological Theory and Theory Construction

Nearly all of sociology's top graduate training programs require their students to complete one or two courses on sociological theory. The instructors for these courses have an extraordinary opportunity to affect the perspectives and practices of future generations of scholars. This study assesses the backgrounds, attitudes, beliefs, and practices of those instructors regarding different approaches to theorizing, with particular attention paid to topics related to science and to theory construction. Soci- ologists who teach required theory courses in the discipline's top fifty grad- uate training programs were asked a series of questions pertaining to their own training and to the courses they were teaching: attitudes toward dif- ferent kinds of theorizing, perceptions of the role that theory plays in sociol- ogy and in science, and views on the nature of science. Results indicate a strong consensus on the most important classical theorists (Marx, Weber, and Durkheim). However, attitudes and practices varied widely in regard to other classical theorists, contemporary sociological theory, and the role of scientific standards in the development of sociological knowledge. The author explores some of the implications of these attitudes and practices.
The effects of testosterone and estrogen on the pituitary growth hormone response to growth hormone-releasing factor.

The effects of testosterone and estrogen on the pituitary growth hormone response to hypothalamic growth hormone-releasing factor (GRF) were evaluated in vivo using male and female rats and in vitro using a pituitary cell monolayer culture system. In vivo the increase in plasma growth hormone (GH) concentration in response to a 500 ng/kg dose of GRF was similar in gonadectomized male and female rats. Pretreatment of intact and gonadectomized male rats with testosterone caused significant enhancement of the pituitary GH response to GRF, whereas pretreatment of gonadectomized female rats with 17 beta-estradiol did not alter the response. The GH response to GRF was not different between prepubertal (i.e., 30-day-old) male and female rats. However, following puberty (i.e., by 60 days of age), the response in male rats was significantly greater than that observed in female rats. The in vitro preincubation of anterior pituitary cells with either testosterone or 17 beta-estradiol did not cause any shift in the dose-response curve between GRF and GH. These results demonstrated that androgens play an active role in modulating the pituitary response to GRF in vivo.
Perceptions of the School Nurse's Role

This study identifies and compares perceptions of school personnel (principals, teachers, counselors and school nurses) about the nurse's role in secondary school settings. A two-part questionnaire was utilized. Part one elicited descriptive data, while part two consisted of 50 Likert-type items related to the school nurse's role. Mean perception scores on the 50 items were obtained by job category and compared using a one-way ANOVA. Chi-square analyses were performed on the frequencies of scale values to determine if their distributions, by item, were the same for all job categories. Correlation coefficients were utilized to determine relationships between training levels, experience, direct contact and perceptions. Analyses revealed: (1) Significant differences in perceptions of the school nurse's role between each group of educators and school nurses. (2) No significant relationship between training level, experience, number of contacts with the nurse and perceptions of the school nurse's role.
Overstory Community Composition and Elevated Atmospheric CO2 and O3 Modify Understory Biomass Production and Nitrogen Acquisition

Elevated atmospheric CO2 and O3 have the potential to affect the primary productivity of the forest overstory, but little attention has been given to potential responses of understory vegetation. Our objective was to document the effects of elevated atmospheric CO2 and O3 on understory species composition and biomass and to quantify nitrogen (N) acquisition by the understory vegetation. The research took place at the aspen free-air CO2 and O3 enrichment (FACE) experiment, which has four treatments (control, elevated CO2, elevated O3, and elevated CO2+O3) and three tree communities: aspen, aspen/birch, and aspen/ maple. In June 2003, each FACE ring was uniformly labeled with 15N applied as NH4Cl. Understory biomass was harvested in June of 2004 for productivity, N, and 15N measurements, and photosynthetically active radiation (PAR) was measured below the canopy. The understory was divided into five species groups, which dominate in this young aggrading forest: Taraxacum officinale (dandelion), Solidago sp. (goldenrod), Trifolium repens and T. pretense (clover), various species from the Poaceae family (grass), and composited minor components (CMC). Understory species composition, total and individual species biomass, N content, and 15N recovery showed overstory community effects, but the direct effects of treatments was masked by the high variability of these data. Total understory biomass increased with increasing light, and thus was greatest under the open canopy of the aspen/maple community, as well as the more open canopy of the elevated O3 treatments. Species were different from one another in terms of 15N recovery, with virtually no 15N recovered in clover and the greatest amount recovered in dandelion. Thus, understory species composition and biomass appear to be driven by the structure of the overstory community, which is determined by the tree species present and their response to the treatments. However, N acquisition by the understory does not appear to be affected by either the overstory community or the treatments at this point.
Automated 2-D Nanoparticle Manipulation Using Atomic Force Microscopy

An automated manipulation procedure for spherical nanoparticles with an atomic force microscope (AFM) in 2-D is demonstrated. Robust particle-center and contact-loss detection algorithms are developed using force feedback to improve speed and reliability issues of AFM-based nanomanipulation. Unlike blind manipulation techniques, contact-loss detection enables better control over the success of manipulation. For pattern formation and assembly operations, a fully automated multiple-particle-manipulation method is developed, based on a commanding task planner. The task planner minimizes the obstacles to manipulation trajectories for better efficiency. Forces during AFM tip-particle-substrate contact are analyzed theoretically to determine the mode of manipulation as well as the effect of cantilever normal stiffness. The developed system is used to form patterns and assemblies of 100-nm-diameter gold nanoparticles on a flat substrate.
Estimates of Faraday rotation with passive microwave polarimetry for microwave remote sensing of Earth surfaces

A technique based on microwave passive polarimetry for the estimates of ionospheric Faraday rotation for microwave remote sensing of Earth surfaces is described. Under the assumption of azimuth symmetry for the surfaces under investigation, it is possible to estimate the ionospheric Faraday rotation from the third Stokes parameter of microwave radiation. An error analysis shows that the Faraday rotation can be estimated with an accuracy of better than 1/spl deg/ with a space-based L-band system, and the residual correction errors of linearly polarized brightness temperatures can be less than 0.1 K. It is suggested that the estimated Faraday rotation angle can be further utilized to derive the ionospheric total electron content (TEC) with an accuracy of about 1 TECU=10/sup 16/ electrons-m/sup -2/ which will yield 1 mm accuracy for the estimate of an ionospheric differential delay at the Ku-band. Therefore, this technique can potentially provide accurate estimates of ionospheric Faraday rotation, TEC and differential path delay for applications including microwave radiometry and scatterometry of ocean salinity and soil moisture as well as satellite altimetry at sea surface height. A conceptual design applicable to real aperture and aperture synthesis radiometers is described for the measurements of the third Stokes parameter.
Mosaic-like Silver Nanobowl Plasmonic Crystals as Highly Active Surface-Enhanced Raman Scattering Substrates

We present a simple approach to creating a type of surface-enhanced Raman scattering (SERS) substrate composed of a mosaic-like structured Ag metal surface on nanobowl plasmonic crystals (NBPCs) formed by combining soft nanoimprinting and substrate (in situ) heating during metal deposition. This new type of sensor exploits the electromagnetic enhancement of localized surface plasmon resonances (LSPR) produced by a template nanostructured metal surface and surface plasmons (SP) in-between the gaps of the mosaic surface to create a highly SERS-active substrate. Our approach is simple, in that it implements low processing temperatures (200 °C) and does not require any postdeposition annealing or exposure to high temperature environments, enabling the use of mechanically flexible substrates. These SERS substrates exhibit higher SERS intensities in comparison to those obtained with the corresponding square array of smooth (room temperature metal deposition) nanobowl structures with similar spatial layouts. As ...
Peaceland: conflict resolution and the everyday politics of international intervention

Severine Autessere’s latest book is an account of the pitfalls that accompany the insularity that often characterizes expatriate communities in peace operations and in humanitarian and development ...