cssi/SciSciGPT-SciSciNet huggingface dataset:
A PRIMITIVE EARWIG IN CRETACEOUS AMBER FROM MYANMAR (DERMAPTERA: PYGIDICRANIDAE)

The earwigs comprise an order (Dermaptera) of polyneopterous insects allied to the Dictyoptera and Grylloblattodea (Giles, 1963; Hennig, 1969; Boudreaux, 1979). Dermaptera have at times in the past been allied with the Phasmida, Embiodea, and Plecoptera (e.g., Blacklith and Blacklith, 1968; Jamieson, 1987) but these relationships do not seem to be congruent with the overall body of data for Polyneoptera phylogeny and the monophyly of a Grylloblattodea + Dermaptera + Dictyoptera clade currently has perhaps more evidence than competing hypotheses (e.g., Carpenter and Wheeler, 1999; Wheeler et al., 2001). However, revised morphological and paleontological evidence may suggest that Dermaptera are basal within Anartioptera—a clade consisting of Plecopterida, Orthopterida, Grylloblattodea, and Mantophasmatodea, as well as the earwigs (e.g., Engel and Grimaldi, 2004). The earwigs are certainly autapomorphic, like many polyneopterous insects, and their definitive placement remains elusive. The order comprises approximately 1,900 species of distinctive insects with relatively flattened bodies, tegminous forewings without venation, an enlarged subgenital plate (sternum 7) in females, trimerous tarsi, and elongate forcipate cerci. Species are fairly mobile and generally prefer damp, concealed habitats such as under bark or stones. The order has a cosmopolitan distribution but is principally found in tropical or warm temperate regions. Two unusual groups, the traditional suborders “Arixeniina” and “Hemimerina,” are apomorphic lineages that are highly specialized for their epizoic lifestyles and at least the latter group has at times been excluded from the order (e.g., Popham, 1973) owing to its peculiar, paedomorphic differences from other earwigs. The five species of arixeniids live in the roosts of molossid bats on Southeast Asia islands (Nakata and Maa, 1974), while the 10 species of hemimerids live under the fur of rodents in Africa (Rehn and Rehn, 1935). The arixeniids have been demonstrated to be derived from the forficuloids, perhaps even …
Use of subtransverse process polyester bands in pediatric spine surgery: a case series of 4 patients with a minimum of 12 months' follow-up.

OBJECT In a previous study, the authors reported on their experience with the use of sublaminar polyester bands as part of segmental spinal constructs. However, the risk of neurological complications with sublaminar passage of instrumentation, such as spinal cord injury, limits the use of this technique. The present study reports the novel use of subtransverse process polyester bands in posterior instrumented spinal fusions of the thoracic and lumbar spines and sacrum or ilium in 4 patients. METHODS The authors retrospectively reviewed the demographic and procedural data of patients who had undergone posterior instrumented fusion using subtransverse process polyester bands. RESULTS Four patients, ranging in age from 11 to 22 years, underwent posterior instrumented fusion for neuromuscular scoliosis (3 patients) and thoracic hyperkyphosis (1 patient). There were 3 instances of transverse process fracture, with application and tensioning of the polyester band in 1 patient. Importantly, there was no instance...
Dynamic Portfolio Choices under Incomplete Information

The essential incentives for investment portfolio managers are pursing relative outstanding portfolio performance among their peers in order to be rewarded by the fractions of the fund inflows. This competition for fund inflows becomes dynamic games among money managers. This paper accordingly proposes a new strategic asset allocation methodology by considering strategic interactions among portfolio managers under the condition of dynamic time of incomplete information. In this research, we extended the approach of Basak et al (2012) by consider the case that portfolio mangers make strategic asset allocations when constructing their portfolios in the way with incomplete-information of their opponents’ behavior. We used continue time to analysis portfolio managers’ strategic interactions under the framework of Bayesian (Nash) equilibrium.
Bis(acetonitrile-κN)(η5-pentamethylcyclopentadienyl) -(pyrimidine-κN)rhodium(III) bis(hexafluoridophosphate)

The title compound, [Rh(C10H15)(C4H4N2)(C2H3N)2](PF6)2 or [Cp*Rh(NCMe)2(N2C4H4)](PF6)2, where Cp* is penta­methyl­cyclo­penta­dienyl, was obtained from the treatment of an acetonitrile solution of [Cp*Rh(NCMe)3](PF6)2 with an excess of pyrimidine. The RhIII center is coordinated by one Cp* ring, two acetonitrile ligands and one pyrimidine ligand in a pseudo-octa­hedral geometry. Both PF6 anions are disordered (site occupancies ca 0.4:0.6, and 0.3:0.4:0.3).
Autologous Transobturator Urethral Sling Placement for Female Stress Urinary Incontinence: Short-term Outcomes

Objective To evaluate short-term outcomes of autologous transobturator (ATO) urethral sling placement using rectus fascia for female stress urinary incontinence. Materials and Methods We evaluated the outcomes of 33 consecutive females who underwent ATO sling placement with rectus fascia for stress incontinence from 2013 to 2014. Patients were seen at 3 months postoperatively and mailed a questionnaire at least 1 year after surgery for further follow-up. Outcomes were measured by the International Consultation on Incontinence Questionnaire Female Lower Urinary Tract Symptoms (ICIQ-FLUTS) score and compared between pre- and postoperative responses using Wilcoxon signed-rank test. Retreatment-free survival rates were evaluated via Kaplan-Meier method. Results Median patient age was 62 years old (interquartile range [IQR] 47.5; 70.5) with a median body mass index of 28.6 kg/m2 (IQR 24.7 kg/m2; 32.4 kg/m2). When isolated sling placement was performed, 88% (15/17) were outpatient procedures. Median follow-up was 14.9 months (IQR 3.6; 18.7), during which 5 patients underwent repeat anti-incontinence surgery. For those without retreatment, 25/28 (89%) completed ICIQ-FLUTS at last follow-up. Compared to preoperative scores, patients who completed ICIQ-FLUTS questionnaires at 1 year or greater (N = 18) showed significant improvement in all domains: frequency (P = .007), voiding (P = .02), and incontinence (P = .004), and in quality of life related to frequency (P = .008), voiding (P = .002) and incontinence (P = .01). Among those who completed questionnaires both at 3 months and at least 1 year after surgery (N = 17), there was no significant deterioration in ICIQ-FLUTS scores. Overall retreatment-free survival rate was 92% at 1 year. Notably, no patients suffered severe (Clavien III-V) complications or required sling release. Conclusion ATO urethral sling placement appears safe, with promising short-term outcomes. Longer follow-up and external validation are needed.
Multifidelity Aerodynamics with Second Order Augmented Kriging Adaptive Sampling

High order simulations such as computational fluid dynamics (CFD) can often be represented with lower computational cost by using a sample to create a correction model on a lower order simulation. Adaptive multifidelity methods based on kriging have been used to sequentially “train” a correction model between a high and low fidelity analyses. For example, the discrepancy between a CFD and potential flow analysis can be fit to a kriging model, and the predicted interpolation uncertainty is used as a criterion to select the input for the next analysis. A shortcoming of such kriging-based approaches is that predictive uncertainties are mainly based on distance from previous observations. Such methods concentrate analyses only where data is sparse, not where it displays highly nonlinear features. The present research therefore uses the second derivative from the kriging mean prediction to augment the predictive variance as a sampling criterion. This method is demonstrated with an algebraic test problem as well as a transonic airfoil with CFD and potential flow. The method is problem dependent; it shows a distinct advantage for the algebraic test problem, but yields inconclusive results for the airfoil problem.
Better home visits for asthma lessons learned from the Seattle-King County Asthma Program.

reviewfocusesoninterventionstoreduceexposuretoasthmatriggersfoundinhomeenvi-ronments,asdidourHealthyHomesIproject.Wefoundthatourclientsareinterestedinlearningaboutthefullspectrumofactivitiestheycandotocontrolasthma,bothenvironmental and medical. The evidence for offeringself-management support for the medical aspects ofasthmacontrolisstrong.
The Importance of Personal Influence in the Adoption of Technological Changes

ments in the postwar period have been in the direction indicated. While the change is most noticeable in superficial forms, there is some evidence that it already has had some effect on the underlying institutional complex. Some indications of such changes are: 1. The lively and many-sided airing of community issues by the local press. 2. Lively expression of citizen opinion through letters to the editor, resolutions, and, where appropriate, protest meetings. 3. A relatively large nucleus of concerned civic leaders who are dissatisfied with civic participation as it is and who see the need for a greater sharing of policy-making responsibility in community matters, both governmental and nongovernmental. 4. Free expression of opinion and comparative freedom from a sense of exaggerated subordination to the opinion of "experts" and "officials" on the part of many youths. 5. The lively efforts of the parents councils, which within the limitations of their formal set-up, have become one of the most vocal and effective community groups. 6. The at least partial success of the various citizens councils in Baden-Wuirttemberg in surviving the withdrawal of American support without becoming dependent for funds on the state. Although none of these developments is immune from the threefold complex and although in some ways they tend to reinforce it, they are not without their influence on it, particularly over a period of time. Thus, even though many concerned civic leaders insist privately that democracy at the community level in Stuttgart is merely a matter of empty forms, there are some slight indications of broader civic participation. Given time, and barring a war, or a national political impasse, or a serious economic depression, they may possibly gather strength as over against the tremendous inertia of the threefold complex.
The Ninth-Floor Pharmacy Project at the University of California, San Francisco: A seminal development in clinical pharmacy.

The planning for a clinical pharmacy practice and decentralized pharmacy service at the University of California, San Francisco (UCSF), Medical Center started in October 1965. After months of planning, services to patients started on September 7, 1966. This article describes the planning,
Social hierarchy and resting metabolic rate in the dwarf cichlid Apistogramma agassizii: the role of habitat enrichment

Differences in aggressiveness when competing for environmental resources are the main factor leading to social hierarchy in group living fish. Social status acquired is related to changes in physiological parameters, as metabolic rate. Habitat variation can interfere with aggressive behaviour and promote changes in physiological parameters associated with social status. The primary goal of our study was to investigate how differences in habitat complexity affect the relationship between resting metabolic rate (RMR) and social status in the Amazonian dwarf cichlid Apistogramma agassizii. We compared agonistic interactions between pairs of males in aquaria with different habitat enrichment levels, manipulated by adding shelters. RMR was measured before and after hierarchy establishment. Habitat enrichment promotes changes in aggressive behaviour and influences differences in metabolic rate between dominant and subordinate fish. We observed an increase in biting by dominant fish at high enrichment habitat, which could be related to the increase in territory value. We observed an increase in metabolic rate in dominant fish after hierarchy establishment. However, it occurs only in enriched habitats. We concluded that habitat structure interfere with behavioural characteristics in social hierarchies, as aggressiveness, and changes in aggressive interactions affect metabolic rate in different social ranks in the dwarf cichlid Apistogramma agassizii.
Numerical Analysis of Hot-Electron Effects in GaAs MESFETs

For the first time, numerical simulation of GaAs metal-semiconductor field-effect transistors subjected to hot-electron-induced degradation was performed. Experimentally observed open-channel current reduction and gate-drain field relaxation were verified. Maximum electric field which governs hot-carrier phenomena was found to depend on Vdg and not on Vds, as in the case of Si MOSFET. Extended surface depletion as a result of traps observed by high-voltage electron-beam-induced current imaging agreed well with Nt of 5×1012 and Lt of 0.1 µ used in simulation.
A Role for Nuclear Actin in HDAC 1 and 2 Regulation

Class I histone deacetylases (HDACs) are known to remove acetyl groups from histone tails. This liberates positive charges on the histone tail and allows for tighter winding of DNA, preventing transcription factor binding and gene activation. Although the functions of HDAC proteins are becoming apparent both biochemically and clinically, how this class of proteins is regulated remains poorly understood. We identified a novel interaction between nuclear actin and HDAC 1 and HDAC 2. Nuclear actin has been previously shown to interact with a growing list of nuclear proteins including chromatin remodeling complexes, transcription factors and RNA polymerases. We find that monomeric actin is able to bind the class I HDAC complex. Furthermore, increasing the concentration of actin in HeLa nuclear extracts was able to suppress overall HDAC function. Conversely, polymerizing nuclear actin increased HDAC activity and decreased histone acetylation. Moreover, the interaction between class I HDACs and nuclear actin was found to be activity dependent. Together, our data suggest nuclear actin is able to regulate HDAC 1 and 2 activity.
Social cognition mediates the relation between attachment schemas and posttraumatic stress disorder.

Objective A social-cognitive perspective on posttraumatic stress disorder (PTSD) has been proposed and posits that impaired social cognition, rooted in attachment insecurity, plays a role in the development of PTSD. Support for the role of impaired social cognition in PTSD has been found in adults, but the social-cognitive perspective on PTSD has not been examined in adolescents. This study sought to explore differences in social cognition and PTSD on the basis of attachment security, and it examined social cognition as a mediator in the relation between attachment security and PTSD and with regard to PTSD symptom change during inpatient treatment. Method We recruited 142 adolescents from an inpatient psychiatric hospital, where adolescents and their parents completed assessments at admission and discharge. Results Adolescents with a secure attachment demonstrated better social-cognitive skills than did those with an insecure attachment. Social cognition mediated the relation between adolescents' maternal attachment representations and PTSD at admission across 3 self- and parent-report measures. Social cognition also mediated the relation between adolescents' maternal attachment representations at admission and PTSD treatment outcome. Conclusion This study provides the 1st support for the application of Sharp, Fonagy, and Allen's (2012) social-cognitive perspective of PTSD to adolescents by showing a link between clinically significant symptoms of PTSD and attachment security through social-cognitive impairment. Findings indicate that improvement in PTSD during medium-stay inpatient treatment is partially driven by baseline attachment security and social-cognitive abilities, highlighting the potential of social-cognitive skills as important targets of clinical intervention among adolescents with PTSD. (PsycINFO Database Record
Effect on Insulin-Stimulated Release of D-Chiro-Inositol-Containing Inositolphosphoglycan Mediator during Weight Loss in Obese Women with and without Polycystic Ovary Syndrome

Background. A deficiency of D-chiro-inositol-inositolphosphoglycan mediator (DCI-IPG) may contribute to insulin resistance in polycystic ovary syndrome (PCOS). Whether the relationship between impaired DCI-IPG release and insulin resistance is specific to PCOS rather than obesity is unknown. We assessed insulin-released DCI-IPG and its relationship to insulin sensitivity at baseline and after weight loss in obese women with and without PCOS. Methods. Obese PCOS () and normal () women underwent 8 weeks of a hypocaloric diet. The Matsuda index, area under the curve DCI-IPG (), , and were measured during a 2 hr OGTT at baseline and 8 weeks. Results. PCOS women had lower at baseline and a significant relationship between and Matsuda index (), which was not present in controls. Weight loss was similar between PCOS (−4.08 kg) and normal women (−4.29 kg, ). Weight loss in PCOS women did not change the relationship between and Matsuda index (), and this relationship remained absent in control women. Conclusion. The association between and insulin sensitivity was only found in PCOS but not in normal women, and this relationship was unaffected by weight loss. DCI and its messenger may contribute to insulin resistance in PCOS independent of obesity.
Interfacial force study on a single bubble in laminar and turbulent flows

Abstract Two-phase flows are present in various industrial processes in engineering fields ranging from light water reactor engineering to petrochemical engineering. In this paper, we conduct the interfacial force study on a single bubble under both laminar and turbulent flow scenarios. Advanced finite-element based flow solver (PHASTA) with level-set interface tracking method is used to perform the studies. The interface tracking approach is verified and validated by analyzing the interfacial forces, i.e., drag and lift forces, and comparing the results with the experiment-based data and correlations. The sign change of transverse migration direction is observed at Eo = 3.4 which is close to the experimental observations. A set of parametric studies, including relative velocity, bubble deformability and turbulent intensity, are performed to analyze the impact of homogeneous turbulent flow on the drag force. A new drag coefficient closure model is proposed which agrees well with the DNS data considering both laminar and turbulent flow. Those studies can complement the experimental database to obtain improved closure laws for interfacial forces and are important contribution to the multiphase computational fluid dynamics (M-CFD) closure model development.
Targeting the stress oncoprotein LEDGF/p75 to sensitize chemoresistant prostate cancer cells to taxanes.

// Leslimar Rios-Colon 1 , Christina K. Cajigas-Du Ross 1 , Anamika Basu 1 , Catherine Elix 1 , Ivana Alicea-Polanco 1 , Tino W. Sanchez 1 , Vinodh Radhakrishnan 1 , Chien-Shing Chen 2 , Carlos A. Casiano 1, 3 1 Center for Health Disparities and Molecular Medicine, Department of Basic Sciences, Loma Linda University School of Medicine, Loma Linda, CA 92354, USA 2 Department of Medicine, Division of Hematology/Medical Oncology, Loma Linda University School of Medicine, Loma Linda, CA 92354, USA 3 Department of Medicine, Division of Rheumatology, Loma Linda University School of Medicine, Loma Linda, CA 92354, USA Correspondence to: Carlos A. Casiano, email: ccasiano@llu.edu Keywords: chemoresistance, LEDGF/p75, prostate cancer, cell death, taxanes Abbreviations: prostate cancer (PCa), docetaxel (DTX), paclitaxel (PTX), cabazitaxel (CBZ), TNF related apoptosis inducing ligand (TRAIL). Received: June 14, 2016 Accepted: October 13, 2016 Published: February 14, 2017 ABSTRACT Prostate cancer (PCa) is associated with chronic prostate inflammation resulting in activation of stress and pro-survival pathways that contribute to disease progression and chemoresistance. The stress oncoprotein lens epithelium-derived growth factor p75 (LEDGF/p75), also known as DFS70 autoantigen, promotes cellular survival against environmental stressors, including oxidative stress, radiation, and cytotoxic drugs. Furthermore, LEDGF/p75 overexpression in PCa and other cancers has been associated with features of tumor aggressiveness, including resistance to cell death and chemotherapy. We report here that the endogenous levels of LEDGF/p75 are upregulated in metastatic castration resistant prostate cancer (mCRPC) cells selected for resistance to the taxane drug docetaxel (DTX). These cells also showed resistance to the taxanes cabazitaxel (CBZ) and paclitaxel (PTX), but not to the classical inducer of apoptosis TRAIL. Silencing LEDGF/p75 effectively sensitized taxane-resistant PC3 and DU145 cells to DTX and CBZ, as evidenced by a significant decrease in their clonogenic potential. While TRAIL induced apoptotic blebbing, caspase-3 processing, and apoptotic LEDGF/p75 cleavage, which leads to its inactivation, in both taxane-resistant and -sensitive PC3 and DU145 cells, treatment with DTX and CBZ failed to robustly induce these signature apoptotic events. These observations suggested that taxanes induce both caspase-dependent and -independent cell death in mCRPC cells, and that maintaining the structural integrity of LEDGF/p75 is critical for its role in promoting taxane-resistance. Our results further establish LEDGF/p75 as a stress oncoprotein that plays an important role in taxane-resistance in mCRPC cells, possibly by antagonizing drug-induced caspase-independent cell death.
Shared Decision-Making

Shared decision-making is a collaborative process whereby patients and their providers make healthcare decisions together, taking into account both the best scientific evidence available and the patient’s values and preferences. Effective implementation of shared decision-making therefore requires ready access to current evidence comparing expected outcomes of decision alternatives, assessment of decision-related values and preferences, and integration of this information to identify the most suitable course of action. Multi-criteria decision analysis (MCDA) is designed to help people make better choices when faced with complex decisions that involve trade-offs between competing objectives. MCDA methods fulfill all of the required elements of shared decision-making. This similarity suggests that MCDA methods could be used effectively to facilitate shared decision-making in practice.
Necrotizing fasciitis of the upper extremity

Thirty-three cases of necrotizing fasciitis of the upper extremity were reviewed. This disease occurs in an indigent patient population and is associated with the abuse of street drugs and/or alcohol. Physical findings may resemble a benign, low-grade cellulitis on admission. Radical debridement of all involved skin, fat, fascia, and muscle within 24 hours of admission is associated with a significant reduction in length of hospital stay and number of operations required.
The Illusion of Transparency.

In “Bringing Transparency to Medicine,” Chimonas, DeVito, and Rothman (2017) provide useful information about how physicians view the Physician Payments Sunshine Act (PPSA). In short, the physician...
Luminescence des pénicillines - I. — Étude de la benzylpénicilline et de l’acide amino-6-pénicillanique

Les proprietes de fluorescence de la benzylpenicilline ont ete confrontees a celles de l'acide amino-6-penicillanique et du phenylacetylamide. Les resultats obtenus, interpretes dans le cadre d'un schema cinetique de desactivation des etats excites, ont permis de montrer que le groupement carbonyle du cycle s lactame a un comportement spectroscopique proche de celui des cetones aliphatiques. L’atome de soufre du cycle thiazolidine exerce un effet inhibiteur sur la fluorescence du cycle benzenique, ce qui permet de preciser la conformation de la chaine laterale en solution aqueuse diluee.
Application of Q-learning to elevator dispatcidng

Abstract This paper addresses the problem of designing an elevator dispatcher to minimize the average passenger waiting time in an office building served by a group of elevator cars. The paper shows how an adaptive dynamic programming algorithm, Q-learning, can be used for both analysis and design. The analysis gives a better understanding of the dispatching problem and the importance of various state information to making dispatching decisions. The design gives a dispatcher which outperforms a commercially representative dispatcher. The results clearly demonstrate the potential capabilities and usefulness of Q-learning for solving discrete event system control problems.
Ex Vivo Rat Eye Model for Investigating Transport of Next Generation Precision-Polyester Nanosystems

We present for the first time a robust ex vivo rat eye model for investigating the transport of precision-polyester nanosystems (P2Ns) across the blood–retinal barrier, intended for systemic administration. The P2Ns-GA actively transport exploiting transferrin receptors present in the inner retinal barrier and colocalize in ganglion cells. Such delivery approaches have the potential to deliver drugs to posterior segments of the eye, which is still a major challenge in treating posterior ocular disorders.
Response of 17 Species of Container-Grown Woody Landscape and Foliage Plants to Four Postemergence Herbicides

Postemergence applications of 2 rates of Whip [fenoxaprop-ethyl) (ethyl 2-[4-[(6 chloro-2-benzoxazolyl) oxy]-phenoxy] propanoic acid), Assure (quizalofop-ethyl) (2-[4-[6-chloro-2-quinoxalinyl) oxy]-phenoxy]-propanolc acid, Fusilade 2000 (fluazifop-p-butyl) (R-butyl 2-[4-(5) trifluoromethyl-2-pyridyloxy)-phenoxy] propanoic acid), and Poast (sethoxydim) (2-[1-(ethoxyamino) butyl]-5-[2-(ethylthio) propyl 1]-3-hydroxy-2 cyclohexene-l-one) were evaluated for phytotoxicity to 17 species of container-grown woody landscape and foliage plants and control of large crabgrass (Digitaria sanguinalis L.). Crabgrass plants were treated at the 2 to 4 and 8 to 10 leaf stages and were grown under both full sun and 40% shade. Each herbicide injured at least one species. Fusilade 2000 injured the fewest species, while Poast injured the most. Under 40% shade, control of crabgrass with 2-4 leaves was acceptable with all herbicides except 0.28 kg/ha (0.25 lb/A) Whip. All herbicides were effective when applied in the 8-10 leaf s...
Comparison of adverse events and postoperative mobilization following knee extensor mechanism rupture repair: A systematic review and network meta-analysis.

Abstract Background Extensor mechanism rupture (EMR) of the knee is a rare but potentially debilitating injury that often occurs due to trauma. While a wide variety of surgical treatments have been reported, there is currently no consensus on the most successful treatment method. The timing of post-operative joint mobilization is also critical for successful recovery after EMR repair. Despite the traditional method of complete immobilization for 6 weeks, there is an increasing trend towards early post-operative knee mobilization. The purpose of this network meta-analysis was to compare adverse event rates and function outcomes between repair methods and between post-operative mobilization protocols. Methods MEDLINE, EMBASE, Web of Science, and Cochrane Central electronic databases were searched in August 2016 for observational studies involving repair of acute, traumatic EMRs. Data extraction included functional outcomes, adverse events, and additional surgeries. Cohort studies that were used in functional outcome analysis were assessed for risk of bias by the Newcastle-Ottawa Quality Assessment Scale (NOS). Results Twenty-three studies (709 patients) were included for adverse event analysis. There were no significant differences in adverse event or additional surgery rates between EMR repair methods However, early mobilization produced significantly higher adverse event rates (p = 0.02) and total event rates (p Conclusions We performed the first network meta-analysis to date comparing treatment of EMRs. Our results support the current body of knowledge that there is no single superior repair method. Although there is an increasing trend towards early or immediate post-operative knee mobilization, we found that early mobilization is associated with significantly higher adverse event and total event rates compared to fixed immobilization for a minimum of 6 weeks, implicating an increased financial burden and decreased quality of life associated with early post-operative mobilization.
Chronic Lower Back Pain: Cognitive Behavioral Therapy With Family Therapy Interventions

Chronic lower back pain is a major health concern involving physical, financial, and social costs for many patients and their family members. Contemporary pain management is guided by the biopsychosocial model in which a professional counselor can contribute to recovery through integrated behavioral health care. Cognitive behavioral therapy (CBT) and behavioral activation interventions are effective in breaking the cycle of chronic pain. Successful outcomes involve partners and family members in CBT, education, and structural family interventions. A case study is presented to examine thoughts and feelings associated with chronic lower back pain. CBT and family interventions contribute to recovery of functions, meaningful roles, and health in relationships.
The NASA Ames PAH IR Spectroscopic Database: Computational Version 3.00 with Updated Content and the Introduction of Multiple Scaling Factors

Version 3.00 of the library of computed spectra in the NASA Ames PAH IR Spectroscopic Database (PAHdb) is described. Version 3.00 introduces the use of multiple scale factors, instead of the single scaling factor used previously, to align the theoretical harmonic frequencies with the experimental fundamentals. The use of multiple scale factors permits the use of a variety of basis sets; this allows new PAH species to be included in the database, such as those containing oxygen, and yields an improved treatment of strained species and those containing nitrogen. In addition, the computed spectra of 2439 new PAH species have been added. The impact of these changes on the analysis of an astronomical spectrum through database-fitting is considered and compared with a fit using Version 2.00 of the library of computed spectra. Finally, astronomical constraints are defined for the PAH spectral libraries in PAHdb.
Ergodic Convergence in Proximal Point Algorithms with Bregman Functions

We prove ergodic convergence results for the proximal point algorithm with Bregman kernels. In the function minimization case, the iterates converge to a minimizer of the function in the ergodic sense. We give global convergence rate estimate for the residual f(zk) — min f(x). In the general case of finding a zero of a maximal monotone operator T, our main result states that, under very general conditions, all limit points of the ergodic solution sequence converge to a zero of T. Under slightly less general conditions, we show that either the original solution sequence convergence to a zero of T, or it stays bounded away from the zero set of T.
Regulation of Ca(2+)-conducting currents in parathyroid cells by extracellular Ca(2+) and channel blockers

High extracellular Ca2+ concentrations ([Ca2+]o) produce sustained intracellular Ca2+ responses in parathyroid cells that correlate with suppression of parathyroid hormone release. Using whole cell patch clamping, we identified two types of Ca(2+)-conducting currents in these cells. Type 1 currents were enhanced by raising [Ca2+]o and blocked by Cd2+ and nifedipine, whereas type 2 currents were resistant to blockade by these agents. Both types of membrane currents were cation nonselective, voltage independent over a broad range of membrane potentials, and blocked by the trivalent ions La3+ and Gd3+ (> 98%). Cd2+, La3+, and Gd3+ had biphasic effects on membrane conductance (Gm). At submicromolar concentrations, these ions increased Gm, whereas at higher concentrations they reduced Gm. In contrast to ionic channel blockers, nifedipine had only an inhibitory effect on the Ca(2+)-conducting currents that were sensitive to changes in [Ca2+]o (dose inhibiting 50% of maximal response = approximately 3-10 x 10(-8) M). Microfluorimetric ratio-imaging analysis of single parathyroid cells loaded with fura 2 showed that Gd3+ inhibited sustained intracellular Ca2+ responses to high [Ca2+]o. These findings suggest that the Ca(2+)-conducting currents identified in these studies may play a role in regulating intracellular Ca2+ responses in this system.
Verifying Text Summaries of Relational Data Sets

We present a novel natural language query interface, the AggChecker, aimed at text summaries of relational data sets. The tool focuses on natural language claims that translate into an SQL query and a claimed query result. Similar in spirit to a spell checker, the AggChecker marks up text passages that seem to be inconsistent with the actual data. At the heart of the system is a probabilistic model that reasons about the input document in a holistic fashion. Based on claim keywords and the document structure, it maps each text claim to a probability distribution over associated query translations. By efficiently executing tens to hundreds of thousands of candidate translations for a typical input document, the system maps text claims to correctness probabilities. This process becomes practical via a specialized processing backend, avoiding redundant work via query merging and result caching. Verification is an interactive process in which users are shown tentative results, enabling them to take corrective actions if necessary. We tested our system on 53 publicly available articles containing 392 claims. Our tool revealed erroneous claims in roughly a third of test cases. Also, AggChecker compares favorably against several automated and semi-automated fact checking baselines.
Vitamin D and Parathyroid Hormone in Kidney Disease

Chronic kidney disease (CKD) is a modern-day epidemic with significant morbidity and mortality. It is well known that CKD is accompanied by reduced conversion of 25-hydroxyvitamin D to 1,25-dihydroxyvitamin D and by deficiency of 25-hydroxyvitamin D. These metabolic changes combined with hypocalcemia and hyperphosphatemia lead to secondary hyperparathyroidism, renal osteodystrophy, and vascular calcification. Attempts to prevent this disorder have led to the widespread use of vitamin D receptor agonists and nutritional vitamin D. This is particularly enhanced by the observational data that support the notion that vitamin D treatment may influence survival especially in patients with end-stage renal disease. Furthermore, calcimimetic agents have demonstrated efficacy for reducing parathyroid hormone (PTH) levels without the risk of hypercalcemia or hyperphosphatemia. In this chapter, we discuss the roles of vitamin D and PTH in the CKD population and outline the current state of evidence supporting their therapeutic use.
The "Comadre" Project: An Asset-Based Design Approach to Connecting Low-Income Latinx Families to Out-of-School Learning Opportunities

Participation in out-of-school learning programs has been shown to generate significant academic, social/emotional, and institutional benefits for young learners, and today's wealthy families are disproportionately reaping these benefits. This paper presents the results of an asset-based/human-centered design research process and pilot aimed at connecting low-income families in a Southern California city with local low-cost out-of-school learning opportunities. Based on background research including qualitative interviewing, home visits, technology inventories and use walkthroughs with 40 low-income, majority Latinx families, we created and piloted a free subscription SMS service that automatically pushes bilingual SMS messages with curated information on local low-cost enrichment learning opportunities to low-income families. We framed our human-centered design process through an intersectional, "asset-based approach," which recognizes that marginalized communities have already developed robust, culturally-specific social practices to enable them to navigate the world, seeks to amplify them, and refrains from imposing a top-down or pre-conceived "idea" of intervention.
5′-Deoxy-5′-Methylthioadenosine Phosphorylase Deficiency in Leukemia: Genetics and Biochemical Aspects

In mammalian cells, 5′-deoxy-5′-methylthioadenosine (MTA) derives from decarboxylated S-adenosyl methionine during spermidine and spermine synthesis.1 To a lesser extent, MTA Is also produced following the aminocarboxypropyl group transfer from S-adenosylmethionine to certain tRNA uridine residues2 (Fig. 1). Although MTA can inhibit polyamine amlnopropyl transferase reactions3, the thioether nucleoside does not accumulate In normal cells but Is rapidly cleaved to adenine and 5-methylthioribose 1-phosphate by the enzyme MTA Phosphorylase. As shown In Figure 1, MTA Phosphorylase is important not only for the balanced synthesis of polyamlnes, but also for the economic Intracellular salvage of adenine nucleotides and methionine. 4, 5 The enzyme is present In all normal tissues studied thus far. Recently, we have assigned the gene for MTA Phosphorylase to the 9pter→9q12 region of human chromosome 9 by analysis of mouse-human somatic cell hybrids.
Freedom From Subjection to the Will of Others: Study Payments, Labor, and Moral Equality.

If the institutions of research involving human subjects are to be justifiable to democratic citizens as a means through which they might advance the common good, then those institutions must respe...
When Low Bone Mineral Density and Fractures Is Not Osteoporosis

To review the differential diagnosis of low bone mineral density (BMD). Osteoporosis is the most common cause of low BMD in adults; however, non-osteoporotic causes of low BMD should be considered in the differential diagnosis of patients with low BMD. Mild osteogenesis imperfecta, osteomalacia, and mineral and bone disorder of chronic kidney disease as well as several other rare diseases can be characterized by low BMD. This review summarizes the differential diagnosis of low BMD. It is important to differentiate osteoporosis from other causes of low BMD since treatment regimens can vary tremendously between these different disease processes. In fact, some treatments for osteoporosis could worsen or exacerbate the mineral abnormalities in other causes of low BMD.
MANUFACTURE AND EVALUATION OF SMALL DIAMETER VASCULAR GRAFTS

ABSTRACT Small diameter vascular grafts were fabricated in our research laboratory. A Teflon coated steel mandrel is mounted on a lathe and rotated at speeds between 0–200 rpm. A nozzle, connected to a pressurized nitrogen gas cylinder, sprays a polymer solution (Polyurethane in Tetrahydrofuran) on the mandrel. The spray nozzle is moved forward and backward in parallel to the mandrel at different speeds. After each cycle of spraying, the polyurethane coat is dried in a still, inert environment and the procedure is repeated until the desired thickness is obtained. The mandrel is finally dried in a vacuum oven and the polymer tube is slipped off for evaluation. A major advantage of the presented fabrication technique is the ability to control various graft properties. Grafts can be made with solid or porous walls by varying gas/liquid ratio, nozzle gage, nozzle movement and mandrel rotation. The mechanical and surface properties of the grafts were measured and analyzed. Although the first grafts were not as compliant as a natural artery, results are encouraging for the search of a viable arterial prosthesis with an excellent long term patency rate.
Linked Lives in Double Jeopardy: Child Incarceration and Maternal Health at Midlife

Parents' relationships with their adult children play an important role in shaping mid and later life health. While these relationships are often sources of support, stressors in the lives of children can compromise parents' health as they age. I consider that a child's incarceration is also a stressor that could imperil parents' health through social, emotional, and economic strains that parents may experience as a result. Using data on 3,159 mothers from the National Longitudinal Survey of Youth 1979 in a series of lagged dependent variable regression models, I find that a child's incarceration is associated with declines in maternal health between ages 40 and 50. These associations are largest for mothers who had grandchildren by their child at the time of the child's incarceration. I close by discussing the implications of child incarceration for intergenerational ties and other social determinants of midlife health.
Separable elements and splittings of Weyl groups

Abstract We continue the study of separable elements in finite Weyl groups, introduced in [11] . These elements generalize the well-studied class of separable permutations. We show that the multiplication map W / U × U → W is a length-additive bijection or splitting of the Weyl group W when U is an order ideal in right weak order generated by a separable element, where W / U denotes the generalized quotient. This generalizes a result for the symmetric group, answering an open problem of Wei [17] . For a generalized quotient of the symmetric group, we show that this multiplication map is a bijection if and only if U is an order ideal in right weak order generated by a separable element, thereby classifying those generalized quotients which induce splittings of the symmetric group, resolving a problem of Bjorner and Wachs from 1988 [4] . We also prove that this map is always surjective when U is an order ideal in right weak order. Interpreting these sets of permutations as linear extensions of 2-dimensional posets gives the first direct combinatorial proof of an inequality due originally to Sidorenko in 1991, answering an open problem Morales, Pak, and Panova [13] . We also prove a new q-analog of Sidorenko's formula. All of these results are conjectured to extend to arbitrary finite Weyl groups. Finally, we show that separable elements in W are in bijection with the faces of all dimensions of several copies of the graph associahedron of the Dynkin diagram of W. This correspondence associates to each separable element w a certain nested set; we give product formulas for the rank generating functions of the principal upper and lower order ideals generated by w in terms of these nested sets, generalizing several known formulas.
The Value of Study Abroad Experience in the Labor Market: Findings from a Resume Audit Experiment

Conventional wisdom and some empirical research suggest that study abroad programs enhance skills and personal growth in ways that translate into success in the labor market. However, this research is limited by its inability to address sources of selection bias that may confound the positive relationship between study abroad experience and labor-market success. To overcome these limitations, we conduct a field experiment where we submitted fictitious resumes to potential employers, randomizing some resumes to list study abroad experience. With this resume audit, we estimate the causal relationship between participation in study abroad experience and the likelihood of receiving a callback from a potential employer. We also tested for potential heterogeneities by the location (i.e., Asia versus Europe) and length (i.e., two weeks versus one year) of the study abroad experience. Compared to resumes that list no study abroad experience, resumes that list study abroad experience in Asia regardless of length are about 20 percent more likely to receive a callback for an interview if the resume listed study abroad experience. The difference in rates increases to 25 percent when comparing resumes without study abroad experience to those that list two-week programs in Asia. Resumes that list study abroad experience in Europe for one year are 20 percent less likely to receive any callback and 35 percent less likely to receive a call back for an interview, relative to resumes that do not list study abroad experience. Implications about the value of study abroad are discussed.
Aspergillus niger fungemia secondary to chronic pulmonary aspergillosis in a patient with invasive squamous cell carcinoma

A 46-year-old man presented with shortness of breath and increased tracheal respiratory secretions. His medical history included a stroke 6 months prior with resultant chronic hypoxic respiratory failure with tracheostomy placement, recently diagnosed thyroid-invasive squamous cell carcinoma and a
A model of the basic components in the seismic Vrancea zone

Seismic processes occur and develop temporally and spatially under the action of internal determinism of global tectonics. Uncertainties related to interlacement of internal physical fields of the Earth and gravity forces of celestial bodies and their effect on global tectonics introduce an element of randomness to models of seismicity. Seismic processes are complicated and multiform because their formation is conditioned by complex variegated geological-geophysical processes occurred in the interior of the Earth and characterized by a set of manifold parameters and the results of their observations are presented as multivariate accidental values. While studying such multivariate processes the question arises: if we can set aside a part of parameters or substitute them by minor number of some of their functions and preserve at the same time all the information? For solving this problem there is a factor analysis based on finding minimal number of factors forming the maximum share of data dispersion. In the studies of the complicated nature of seismicity the factor analysis forwards a deeper understanding of the essence of seismic processes because interrelation of seismic parameters must be conditioned by parameter relations which revealing is a task of factor analysis. The modern models of seismicity and the theories explaining appearance of the earthquakes are based on indirect data, mainly on seismic observations. The basic mission of geophysical studies is solving of inverse problem, i. e. determination of the structure of the medium according to observations of physical fields characteristics. Special features of seismic actions of each earthquake is determined by such of its characteristics as tectonics, the depth of a focus, mechanism, geometry of the focus, direction and the running of the process of rocks rupture and other parameters. The pattern of a microseismic field is a reflection of all these factors effect and of local geological features on manifestations of seismic effect in the sites of day surface.
Surveying journalists in the “New Normal”: Considerations and recommendations:

As journalism undergoes widespread changes, it finds itself in a ‘new normal’. Research seeking to understand these changes by surveying journalists faces new methodological hurdles that span diffe...