cssi/SciSciGPT-SciSciNet huggingface dataset:
Age-related differences in the response of hepatic microsomal glucose-6-phosphatase to triiodothyronine and triamcinolone in the rat.

A previous report from this laboratory demonstrated age-related differences in the hormonal regulation of hepatic glucose-6-phosphatase (G-6-Pase). A detailed kinetic analysis of G-6-Pase activity has been performed to distinguish between effects on the microsomal carrier for glucose-6-phosphate and those on the enzyme itself. The maximum velocity (Vmax) was determined in untreated microsomes and microsomes treated with sodium deoxycholate (DOC); the Vmax of the enzyme (VE) was equal to the Vmax in the presence of DOC, and the Vmax of the carrier (VT) was calculated from the Vmax of untreated microsomes and the latency (the activity of DOC-treated microsomes not expressed by the intact preparation). The age-related decrease in G-6-Pase activity was caused by a decrease in the VE. In 3-month-old rats, the VE was increased 2.5-fold by treatment with T3, whereas triamcinolone or the two hormones in combination caused little effect; in 24-month-old animals, the VE was increased 10-fold by T3 and 2-fold by eit...
Pattern recognition proteins in Manduca sexta plasma.

Recognition of nonself is the first step in mounting immune responses. In the innate immune systems of both vertebrates and arthropods, such recognition, termed pattern recognition, is mediated by a group of proteins, known as pattern recognition proteins or receptors. Different pattern recognition proteins recognize and bind to molecules (molecular patterns) present on the surface of microorganisms but absent from animals. These molecular patterns include microbial cell wall components such as bacterial lipopolysaccharide, lipoteichoic acid and peptidoglycan, and fungal β-1,3-glucans. Binding of pattern recognition proteins to these molecular patterns triggers responses such as phagocytosis, nodule formation, encapsulation, activation of proteinase cascades, and synthesis of antimicrobial peptides. In this article, we describe four classes of pattern recognition proteins, hemolin, peptidoglycan recognition protein, β-1,3-glucan recognition proteins, and immulectins (C-type lectins) involved in immune responses of the tobacco hornworm, Manduca sexta.
Room temperature photoluminescence from [Pt(4′-CCR-tpy)Cl]+ complexes

The synthesis, photophysics, electronic structure, and electrochemical characterization of 4′-tert-butylacetylene-2,2′:6′,2″-terpyridineplatinum(II) chloride (1), 4′-phenylacetylene-2,2′:6′,2″-terpyridineplatinum(II) chloride (2), and their ZnII analogs are described. The PtII complexes display interesting photophysical properties, showing vibronically resolved emission spectra at room temperature in CH2Cl2, resembling a ligand localized emission profile. The photophysics and 1O2 sensitization experiments support a triplet state assignment for these emissions which are best described as an admixture of charge transfer and ligand localized components, which decay symmetrically with time as evidenced by time resolved emission spectra. Room temperature ligand-localized fluorescence emission is observed from the zinc complexes whereas phosphorescence emission from the 3π–π* manifold was obtained at 77 K in 4 : 1 EtOH/MeOH matrices doped with 10% ethyliodide. Compounds 1 and 2 display long-lived emission at room temperature, the latter possessing a longer lifetime, higher quantum yield, and longer wavelength emission. Lowering the temperature from 298 K to 77 K induces an increase in the excited state lifetime of both platinum systems together with a blue shift in their respective emission maxima, concomitant with more pronounced vibronic structure. The data are consistent with configurationally mixed triplet excited states at room temperature which persists in 77 K glasses. The corresponding Zn(II) complexes display significantly higher energy ligand-localized phosphorescence at 77 K. This latter result suggests that the nature of the metal and/or coordination environment imparts a significant electronic pertubation into the ligand-localized triplet states of these conjugated terpyridyl structures.
Rewarding Good Citizens: The Relationship Between Citizenship Behavior, Gender, and Organizational Rewards

University of South FloridaThe relationship between organizational citizenship behavior (OCB) and two or-ganizational rewardsFsalary and promotionFwas examined. Employee genderalso was tested as a moderator. Data from 440 individuals employed in multiplesettings indicated that individuals who reported engaging more frequently in OCBdirected toward the organization (OCBO) also reported receiving more promotions.Further, results indicated that gender was a moderator such that the relationshipbetween OCBO and promotion was stronger for males than for females. The resultsalso revealed an interaction between OCB directed toward individuals (OCBI) andOCBO. Specifically, high OCBI and low OCBO related to lower promotion ratesthan did low OCBI and low OCBO. Results are discussed in terms of implicationsfor individual career development.
Immunolocalization of Subtype 2 Angiotensin II (AT2) Receptor Protein in Rat Heart

Abstract —Angiotensin II exerts its effects on cardiovascular function and water and sodium homeostasis by interacting with plasma membrane receptors on target organs. The existence of subtype 2 angiotensin II (AT 2 ) receptors in the rat heart has been demonstrated by ligand binding and reverse transcription–polymerase chain reaction. In the present study, the expression and localization of AT 2 receptor protein in the rat heart was investigated using an antipeptide polyclonal antibody against the native rat AT 2 receptor by light microscopic immunocytochemistry and Western blot analysis. In frozen tissue sections, positive immunostaining was observed in the myocardium and coronary vessels throughout the ventricle and atrium of neonatal and young rat hearts. Coronary vessels of the neonatal heart were more intensely stained compared with the surrounding myocardium. Positive immunoreactivity in the coronary vessels of young rats was localized to vascular endothelium but not in the smooth muscle cells. Preadsorption controls were all negative. Western blot analysis showed that the AT 2 receptor protein (≈44 kDa) was detectable from the AT 2 receptor–transfected COS-7 cells and neonatal rat cardiac myocytes but not from fibroblasts or young rat aortic smooth muscle cells. The neonatal rat heart expressed significantly more AT 2 receptors than young rat heart. These data provide the first direct evidence for the expression and localization of AT 2 receptor protein in the rat heart.
Trilinos I/O Support Trios

Trilinos I/O Support Trios is a new capability area in Trilinos that serves two important roles: 1 it provides and supports I/O libraries used by in-production scientific codes; 2 it provides a research vehicle for the evaluation and distribution of new techniques to improve I/O on advanced platforms. This paper provides a brief overview of the production-grade I/O libraries in Trios as well as some of the ongoing research efforts that contribute to the experimental libraries in Trios.
Principals’ Approaches to Cultivating Teacher Effectiveness Constraints and Opportunities in Hiring, Assigning, Evaluating, and Developing Teachers

Purpose: How principals hire, assign, evaluate, and provide growth opportunities to teachers likely have major ramifications for teacher effectiveness and student learning. This article reports on the barriers principals encountered when carrying out these functions and variations in the degree to which they identified obstacles and problem-solved to surmount them. Research Methods: I conducted semistructured interviews with 30 principals in charter or conventional schools in two adjacent northeastern states. State A has been at the national forefront of efforts to raise teacher effectiveness. State B is a particularly strong union setting. Charter school principals constituted 23.3% of the sample; 53% of principals worked in urban schools. After coding interview transcripts, I used thematic summaries, categorical matrices, and analytical memos to identify themes across participant experiences. Findings: Principals encountered barriers to cultivating teacher effectiveness that were economic, contractual, cultural, and interpersonal. Principals with more professional development regarding
Exploring the relationship between retrieval disruption from collaboration and recall

When people recall together in a collaborative group they recall less than their potential. This phenomenon of collaborative inhibition is explained in terms of retrieval disruption. However, collaborative recall also re-exposes individuals to items recalled by others that they themselves might otherwise have forgotten. This re-exposure produces post-collaborative benefits in individual recall. The current study examined whether reduced retrieval disruption during group recall is related not only to less collaborative inhibition, but also to greater post-collaborative recall benefits. To test this we devised a paradigm to calculate the extent to which each individual experienced retrieval disruption during group recall. We also included two types of collaborative groups, one of which was expected to experience greater retrieval disruption than the other. Results suggest that the relationship between retrieval disruption and recall performance depends on the level at which retrieval disruption is measured. When retrieval disruption was assessed at the individual level, then minimising retrieval disruption was associated with higher recall (i.e., less collaborative inhibition and greater post-collaborative individual recall). However, when retrieval disruption was assessed at the group level there was no relationship with recall. Furthermore, the findings from this design suggest a role of cross-cueing in modulating group recall levels.
Avoiding cache thrashing due to private data placement in last-level cache for manycore scaling

Without high-bandwidth broadcast, large numbers of cores require a scalable point-to-point interconnect and a directory protocol. In such cases, a shared, inclusive last level cache (LLC) can improve data sharing and avoid three-way communication for shared reads. However, if inclusion encompasses thread-private data, two problems arise with the shared LLC. First, current memory allocators align stack bases on page boundaries, which emerges as a source of severe conflict misses for large numbers of threads on data-parallel applications. Second, correctness does not require the private data to reside in the shared directory or the LLC. This paper advocates stack-base randomization that eliminates the major source of conflict misses for large numbers of threads. However, when capacity becomes a limitation for the directory or last-level cache, this is not sufficient. We then propose non-inclusive, semi-coherent cache organization (NISC) that removes the requirement for inclusion of private data and reduces capacity misses. Our data-parallel benchmarks show that these limitations prevent scaling beyond 8 cores, while our techniques allow scaling to at least 32 cores for most benchmarks. At 8 cores, stack randomization provides a mean speedup of 1.2X, but stack randomization with 32 cores gives a speedup of 2.7X over the best baseline configuration. Comparing to conventional performance with a 2 MB LLC, our technique achieves similar performance with a 256 KB LLC, suggesting LLCs may be typically overprovisioned. When very limited LLC resources are available, NISC can further improve system performance by 1.8X.
Effect on Electrical Properties of Barium and Strontium Additions in the Lead Lanthanum Zirconate Stannate Titanate System

The effect of barium (Ba) and strontium (Sr) additions on the electrical properties of lead lanthanum zirconate stannate titanate (PLZST) ceramics and their electrically induced phase change behavior was examined. Sr additions decreased both the ferroelectric (FE) ↔ antiferroelectric (AFE) transition temperature (T AFE-FE ) and the temperature of the maximum dielectric constant (T MAX ). This indicates that Sr additions stabilize the AFE phase. Along with B-site modifications Sr additions can be used to decrease the switching field and hysteresis. Ba additions caused the temperature range of the AFE phase to narrow by increasing T AFE-FE and decreasing T MAX . This behavior indicates an ability to lower the switching field and suppress hysteresis. Using a combination of both A-site and B-site modifications it is possible to tailor the properties (for example, switching field, hysteresis, and operating temperature range) of this group of phase change materials to meet the requirements of specific applications.
Resection of the primary colorectal cancer is not necessary in nonobstructed patients with metastatic disease.

Asymptomatic patients with metastatic colorectal cancer do not routinely need to undergo resection of the primary tumor. Although several retrospective analyses suggest that patients who undergo resection of the primary tumor livelonger,mostoftheserevieweddatapriortotheadvent of modern polychemotherapy and are subject to considerablebias,aspatientswhowereconsideredabletoundergo surgerylikelyhadbetteroverallprognosesthanthosewho were not. In addition to significant prolongation of overall survival, current combinations of systemic chemotherapeutic agents and targeted agents have allowed improved local and distant tumor control, decreasing the likelihood of local tumor-related complications requiring colon resection. The Oncologist 2009;14:963–969
Protective Coupling of Mitochondrial Function and Protein Synthesis via the eIF2α Kinase GCN-2

Cells respond to defects in mitochondrial function by activating signaling pathways that restore homeostasis. The mitochondrial peptide exporter HAF-1 and the bZip transcription factor ATFS-1 represent one stress response pathway that regulates the transcription of mitochondrial chaperone genes during mitochondrial dysfunction. Here, we report that GCN-2, an eIF2α kinase that modulates cytosolic protein synthesis, functions in a complementary pathway to that of HAF-1 and ATFS-1. During mitochondrial dysfunction, GCN-2–dependent eIF2α phosphorylation is required for development as well as the lifespan extension observed in Caenorhabditis elegans. Reactive oxygen species (ROS) generated from dysfunctional mitochondria are required for GCN-2–dependent eIF2α phosphorylation but not ATFS-1 activation. Simultaneous deletion of ATFS-1 and GCN-2 compounds the developmental defects associated with mitochondrial stress, while stressed animals lacking GCN-2 display a greater dependence on ATFS-1 and stronger induction of mitochondrial chaperone genes. These findings are consistent with translational control and stress-dependent chaperone induction acting in complementary arms of the UPRmt.
Modified smoothed particle hydrodynamics method and its application to transient problems

A modification to the smoothed particle hydrodynamics method is proposed that improves the accuracy of the approximation especially at points near the boundary of the domain. The modified method is used to study one-dimensional wave propagation and two-dimensional transient heat conduction problems.
Homogenous Good Outcome in a Heterogeneous Group of Tumors: An Institutional Series of Outcomes of Superficial Soft Tissue Sarcomas.

Introduction. Superficial soft tissue sarcomas (S-STS) are generally amenable to wide excision. We hypothesized that local recurrence (LR) should be low, even without radiation therapy (RT), and sought to examine the contribution of depth to LR and OS. Methods. Patients with S-STS were retrospectively reviewed. Demographics, tumor features, treatment received, and outcomes were analyzed. Results. 103 patients were identified. Median age was 55 years; 53% of patients were female. Tumor site was 39% in trunk, 38% in the lower extremity, 14% in the upper extremity, and 9% in other locations. The most common histology was 36% leiomyosarcoma. Median tumor size was 2.8 cm (range 0.2–14 cm). Sixty-six percent of tumors were of intermediate/high grade. RT was administered preoperatively in 6% of patients and postoperatively in 15% of patients. An R0 resection was accomplished in 92%. At a median follow-up of 34.2 months (range 2.3–176), 9 patients had a LR (8.7%). Tumor size and grade were not associated with LR. OS was not associated with any tumor or patient variables on univariate analysis. Conclusions. LR was low for S-STS, even with large or high grade tumors and selective use of RT. Surgical resection alone may be adequate therapy for most patients. Superficial location seems to supersede other factors imparting a good prognosis for this group of tumors.
Nonsurgical Treatment for AVMs

The treatment of choice of small symptomatic cerebral arteriovenous malformations (AVMs) in noneloquent regions is neurosurgical resection. In selected regions (deep structures, eloquent areas), the morbidity and mortality associated with surgical resection may exceed the risk from the disease itself. In selected patients, transvascular embolization may be of benefit in alleviating the symptoms or reducing the risks of the disease. Decisions as to the timing and type of treatment are complex and should by made by a team of neurologists, neurosurgeons, radiologists, and radiotherapists. Relatively few patients at our institution are treated by embolization alone; rather a combination of preoperative, intraoperative, and preradiation embolizations are far more common. A few of the more common indications for embolization are delineated below.
CONTROL OF LUMINESCENCE IN HEMICHORDATES AND SOME PROPERTIES OF A NERVE NET SYSTEM.

1. Luminescence in Ptychodera and Balanoglossus is normally neurally mediated. 2. The main luminescence appears to be intracellular; in addition a luminous slime is secreted. 3. The response of individual photocytes is all-or-none, but requires neuroeffector facilitation which grades intensity by recruitment (in contrast to crustacean muscle). 4. Repetitive discharge, both to mechanical and single electrical stimuli, is considered to be a prime factor together with interneural and neuro-effector facilitation, in determining spread of excitation in the general plexus. 5. Four types of spread of luminescence occur, differing in conduction velocity polarization of spread, area of spread, necessary conditions for elicitation and adequate stimulus. At least three different neural pathways are involved. 6. Prolonged autoexcitatory displays produce luminous waves arising repetitively from the same locus and from multiple loci; the general plexus is implicated. 7. There is a diurnal rhythm of responsiveness to stimuli. This is attributed to the photocyte rather than to the nervous system.
Cycles in Graphs and Groups

If a group G of automorphisms of a graph Γ acts transitively on the set of vertices, then Γ is d-valent for some d: each vertex is adjacent to exactly d others. This note concerns cycles in Γ, by which we will mean subgraphs isomorphic to a k-cycle for some k ≥ 3; hence there will be no “initial” vertex. If g ∈ G and C is a cycle in Γ, then g(C) is another cycle in Γ: G acts on the set of all cycles in Γ. There is another meaning of the word “cycle”: each element of G can be written as a product of disjoint cycles of the set of vertices. If C = (1, . . . , k) is such a cycle and g ∈ G, then an elementary calculation gives gCg−1 = (g(1), . . . , g(k)), and this is just g(C) if C is viewed as a cyclically ordered set of vertices. In other words, the conjugation and functional actions behave the same. In a 1971 lecture, J. H. Conway [6] presented the following result, which merges these two meanings of “cycle” when G can move any ordered pair of adjacent vertices to any other such pair:
Coming to America for Spiritual or Academic Growth? Experiences of International Students at One Christian School

The number of international students flocking to North American private Christian schools has continued to grow. The author examined the overall experiences of 67 international high school students studying at a private Christian school in South Carolina. Their frustrations and struggles with academic and spiritual growth in a new cross-cultural setting, their reasons for coming to study in the United States at their own expense, as well as their motivations to come to the United States were investigated. The findings signified that none of the participants came to the Christian school for a Christian education, but for a good academic education and a bright future. In addition, the absence of their home cultures, the lack of academic language, and the large culture distance contributed to their frustrations and struggles in the process of adaptation to the new school environment.
Differential Paths to Parity: A Study of the Contemporary Arms Race

This article presents a model of arms expenditures and arms accumulation for the Soviet Union and United States from 1952 through 1978. It argues that contemporary superpowers do not react solely to the military budgets of one another in assessing the potential threat against which they must allocate military resources, i.e., in deciding upon the military budget. Rather, they respond primary to the relative balance of strategic and conventional military forces. A continuous time model of this process is developed and estimated. If one examines only the budgets of these two nations, it would appear that no race is occurring; rather, the Soviets are simply increasing their arms expenditures irrespective of what the United States does. However, when one examines the relative stocks of military capabilities, it appears that the USSR is racing to catch up to the United States. Finally, the dynamics governing arms competition between the United States and the USSR appear to be undergoing marked change.
THE MATING SYSTEM OF THE TERRESTRIAL SLUG DEROCERAS LAEVE.

BENNETT, S. E. 1980. Interspecific competition and the niche of the American Redstart (Setophaga ruticilla) in wintering and breeding communities, p. 319-335. In A. Keast and E. S. Morton (eds.), Migrant Birds in the Neotropics: Ecology, Behavior, Distribution, and Conservation. Smithsonian Inst. Press, Washington, D.C. DAVIES, N. B., AND A. I. HOUSTON. 1981. Owners and satellites: the economics of territory defence in the pied wagtail Motacilla alba. J. Anim. Ecol. 50:157-180. KREBS, J. R. 1982. Territorial defense in the great tit: do residents always win? Behav. Ecol. Sociobiol. 11: 185-194. MAYNARD SMITH, J., AND G. A. PARKER. 1976. The logic of asymmetric contests. Anim. Behav. 24: 159-175. PROCTER-GRAY, E., AND R. T. HOLMES. 1981. Adaptive significance of delayed attainment of
Experimental production of sarcomas by methyl methacrylate implants.

SummarySubcutaneous implantation of methyl methacrylate film in mice resulted in a 25% incidence of fibrosarcomas. The incidence of fibrosarcomas was 14.3% with cellophane implants.
Review: From Bauhaus to Ecohouse: A History of Ecological Design by Peder Anker

Peder Anker . From Bauhaus to Ecohouse: A History of Ecological Design . Baton Rouge: Louisiana State University Press, 2010, 177 pp., 8 b/w illus. $34.95, ISBN 9780807135518 On the second page of From Bauhaus to Ecohouse: A History of Ecological Design, Peder Anker shares the life-altering experience that eventually caused him to write this important yet flawed account of ecological design in the twentieth century. As a Norwegian youngster, he traveled for a family vacation to the Epcot Center at Disney World, and he left Florida certain that that prototypical community of the future did not belong to his future. "This book is an attempt to come to terms with this ecological line of reasoning, and it proceeds according to my own trajectory from Europe to the United States," he writes (2). Anker's early admission alerts the reader that much of the book might be inflected by this distressing childhood experience, and such a suspicion is frequently reinforced. Despite this agenda-driven inquiry, From Bauhaus to Ecohouse reveals a rich range of connections between unlikely twentieth-century architects, designers, policy makers, and ecologists. It provides a multitude of new story lines to consider. As the title indicates, Anker begins with the Bauhaus, specifically with Walter Gropius and Laszlo Moholy-Nagy during their period as emigres in 1930s London, where they met and interacted with Julian Huxley, H. G. Wells, ecologist Max …
Synthesis of Nanosize Tungsten Oxide and Its Evaluation as an Electrocatalyst Support for Oxygen Reduction in Acid Media

WO3 was investigated as a possible support material for monolayer Pt ORR electrocatalysts in acid electrolyte. It was found that as-prepared Pt/WO3 showed enhanced activity for the ORR and superior electron transfer ability compared to conventional Pt/C and bulk polycrystalline Pt. However, similar to other tungsten derived supports, most notably WC, the Pt/WO3 electrocatalyst showed significant performance degradation that was tied directly to the formation of water-soluble hydrogen tungsten bronze (HxWO3) on the support surface that was identified by X-ray photoelectron spectroscopy (XPS) and transmission electron microscopy (TEM). This information, combined with previous work by our group on WC supports, are also combined to propose a series degradation pathway for WC and WO3 supports in acid media, which is relevant for proton exchange membrane (PEM) fuel cells.
Power system cascading failure analysis theories and application I——related theories and applications

Power supply ability and operation profit have been promoted by increasing power grid interconnection, which also leads to a higher level of cascading failures risk. Large-scale blackout caused by cascading failures happened several times in recent years. It is quite meaningful to comprehensively analyze power system cascading failures theories, mathematical features and application scenarios. In this area, a series of theories and modeling methods both with academic and practical values have been proposed in the last ten years. First of all, the intensive study is performed for essential features of cascading failure process, as well as the internal and external impact factors and required information. After listing the major difficulties of modeling approach, a comprehensive technical review of related algorithm is presented, which thus is expected to offer a clear scope for the future research. Last but not least, for the further discussion, some practical software and cascading failures algorithm used in the foreign power system industry are consequently introduced, which is expected to provide enlightenment for the advanced application in the power grid operation in China.
Realization of subnanosecond power conditioning by using transmission line charging technique

The wave process and principle of the transmission line charging in impedance matched and mismatched condition are analyzed.The results show that the impedance mismatched charging technology can realize the power gain but lower the energy efficiency,while the impedance matched charging technology can obtain an energy transmission efficiency of 100%, but can't realize the power gain.The radiation fields of the 5 Ω charged transmission line with length of 30,45,60 mm are studied experimentally,using 27 Ω charging transmission line,which is 540 mm long.A output pulse with risetime about 210 ps and peak voltage about 150 kV is obtained on the 5 Ω charged line,which is 45 mm long.The radiation electric field increases a little as the length of the charged transmission line increases,the maximum electric field is up to 49 kV/m at 6 m away from radiation antenna.Considering the energy loss of air spark gap,the experimental result agrees with the theoretical analysis.
STUDY ON ELECTROMAGNETIC AND STRUCTURAL PARAMETERS IN TWO-STAGE SOFT CONTACT SLIT-LESS MOLD

Numerical simulation and orthogonal experiment were used to study the effects of some factors,such as thickness of mold wall(d),resistivity of the top half of the mold(ρ),electrical frequency(f)and coil current intensity(I),on the penetration of magnetic field in two-stage soft contact electromagnetic continuous casting slit-less mold.The magnetic flux density(B)is decreased with increasing f and d,but increased with increasingρandⅠ.The order of factors affecting the penetration of magnetic field in two-stage mold is f,ρ,Ⅰ,d.By dimensionless analysis,the relation between B and above four parameters was given as B/(μ_0I/d)=4.36×10~9(ρ/If)~(0.89).Finally,the ideal parameters of two-stage soft contact electromagnetic continuous casting mold were obtained:d=5mm, p=8.8×10~(-7)Ω·m,I=2000 A,f=2500 Hz.
Quality control of nitrite in milk product under laboratory conditions

Though controlling the method precision and accuracy,we got the result:the method precision was 0.273mg/kg,the upper and lower line of warning were 0.294 mg/kg,0.252mg/kg respectively,and the upper and lower controlling line were 0.304 mg/kg,0.242mg/kg respectively,the method accuracy was that the rate of recovery changing between 80.0%~118.0%.
Culture Heritage Digital Repositories. Research Questions.

This discussion is about innovative solutions for assembling multimedia digital repositories for collaborative use in specific contexts and communities and enhancing scholarly understanding and experiences of digital cultural heritage. Several aspects are stress such as the dynamic aggregation of cross-media resources across existing institutional digital libraries and repositories. Research questions about the scalability, interoperability and distributed architectures, aggregation, and semantic search tools are addressed.
Adenocarcinoma of the Prostate Involving 2 Cell Types (Prostate Specific Antigen Producing and Carcinoembryonic Antigen Producing) with Selective Metastatic Spread

AbstractOf 3 patients with clinically localized adenocarcinoma of the prostate 2 were treated by radical prostatectomy and 1 was treated with radiation therapy. Serum prostate specific antigen (PSA) values were elevated before therapy. After treatment the PSA levels were decreased to zero. All 3 patients later had evidence of metastatic tumor spread to the liver with elevation of serum carcinoembryonic antigen but not PSA. Immunohistochemical staining of the 2 primary tumors from the prostatectomy specimens identified 2 cell clones, one immunoreactive to PSA and prostatic acid phosphatase (PAP) and nonimmunoreactive to carcinoembryonic antigen, and the other immunoreactive to carcinoembryonic antigen but not PSA or PAP. Biopsy of a hepatic metastasis in 2 patients confirmed anaplastic carcinoma of the carcinoembryonic antigen-producing cell type. Immunohistochemical staining of a lymph node metastasis identified the PSA-producing cell type only. Such results suggest selective metastatic spread of each cel...
A bisimulation-like algorithm for abstracting control systems

Motivated by the recent interest in abstraction-based correct-by-construction control synthesis, in this paper we propose a new algorithm to construct finite abstractions for “large”, possibly infinite, transition systems. As opposed to the standard bisimulation algorithms that create a partition of the state space, the new algorithm uses overlapping subsets of the state space as the states of the abstraction. We show that the output of the new bisimulation-like algorithm preserves realizability of linear-time properties. Several interesting properties of the algorithm are analyzed. In particular, when a finite bisimulation of the original system exists, the new algorithm is shown to always terminate in a finite number of steps. Moreover, we show with an example that even when the original system does not have a finite bisimulation, the new algorithm can result in a finite transition system whose infinite traces are equivalent to those of the original system. In the second part of the paper, we focus on the application of this algorithm to construct finite abstractions for discrete-time linear control systems and discuss several of its advantages over the standard bisimulation algorithm. Finally, the new algorithm is compared to the existing algorithms with some numerical examples.
Current vs past use of NSAIDs was linked to increased risk for first HF hospitalization; risk varied by drug.

Source Citation Arfe A, Scotti L, Varas-Lorenzo C, et al; Safety of Non-steroidal Anti-inflammatory Drugs (SOS) Project Consortium. Non-steroidal anti-inflammatory drugs and risk of heart failure i...
On bifurcation of limit cycles from centers

For a one parameter family of plane vector fields X (·,≥) depending analytically on a small real parameter ≥, we determine the number and position of the local families of limit cycles which emerge from the periodic trajectories surrounding a center. Aside from the intrinsic interest in the example we choose, it serves to illustrate some techniques which are developed for treating similar bifurcation problems when the first order methods are inconclusive. Actually, we are able to treat the bifurcations of all orders.
Violence, the State, and the Poor: A View from the South†,‡

What are the basic contours of a political sociology of violence at the urban margins? Drawing on past and current ethnographic research in a poor area of Buenos Aires, this article calls for systematic research of the points of contact (overt and covert) between agents of the state and the poor. We argue that as part and parcel of the illicit drug trade, clandestine interventions of the state intensify interpersonal violence.
CRT-700.14 Reduction in Radiation and Contrast Dose in Transcatheter Aortic Valve Replacement Over Time: A Single-Center Experience

Transcatheter aortic valve replacement (TAVR) is recommended for severe aortic valve stenosis (AS). This study aims to evaluate the assosiation between radiation dose, time and contrast dose in TAVR with improved experience over time. A Retrospective analysis of 570 patients with severe AS who
A two-level ICA approach reveals important differences in the female brain response to thermal pain

Pain is subjective, while pain neuroimaging analysis methods need to be as objective as possible. Most neuroimaging studies use a general linear model (GLM) approach which heavily relies on a number of key assumptions. Independent component analysis (ICA), on the other hand, is a data-driven approach and hence significantly reduces need for specific assumptions such as Gaussian distributed residuals and the definition of user-specified design matrix, both required by the GLM. In this paper, we propose a two-level ICA-based method as an attractive alternative, and apply it to the analysis of functional magnetic resonance imaging (fMRI) data acquired during thermal pain stimuli. We identify distinct female brain responses in parts of the "pain matrix", operculum (secondary somatosensory cortex, SII), anterior insular (AI), dorsal anterior cingular cortex (dACC), and default mode network (DMN). We also show that this pain and DMN network have significant correlation with behavioral measures.
Rehearsals in Clinical Placements: Scaffolding Teacher Candidates' Literacy Instruction.

Rehearsals are lesson enactments with feedback prior to implementation with students, and are one facet of practice-based teacher education with an aim to promote ambitious teaching in all ...
The Growth of Remote Sensing through the Nimbus and ERTS Spacecraft

Less than fourteen years ago, most of us experienced a great thrill in listening to the radio signals sent from the first man-made Earth-orbiting satellite. In fact, it will be exactly fourteen years two weeks from today that Sputnik I was launched and achieved its electrifying orbit around the Earth. Since that time many other achievements have added to this new technology of space flight. One of these happened about a decade ago when we had first look at our Earth from space taken by a television camera aboard another man-made satellite. Since that date literally hundreds of thousands of photographs, both in the IR and visible spectrum, have been produced by a variety of sensors carried by a variety of automated and manned earth-orbiting satellites. Open image in new window Fig. 1 Nimbus 4 satellite.
Asymmetric Costs of Errors in Affective Perspective-Taking

Accurately assessing other people’s perspective in general, and other people’s emotional responses in particular, is essential for successful social interaction. However, substantial research finds...
Purification of a leucine-specific binding protein from Escherichiacoli

Abstract A new binding protein for leucine was purified from E. coli and crystallized. It appears to be similar in size to a protein, previously isolated from E. coli which binds leucine, isoleucine and valine. The new protein, however, binds only leucine. Furthermore, the amino acid analogue trifluoroleucine effectively inhibits the binding of leucine to the leucine-specific binding protein whereas, it is without effect on the protein that binds all three amino acids. The KD for leucine binding is 0.7 μM. The nature of the inhibition of leucine transport by trifluoroleucine and isoleucine suggests that there is more than one transport system for leucine.
How China's Crackdown on Corruption Has Led to Less Transparency in Its Enforcement of Its Anti-Bribery Laws

China’s recent crackdown on government corruption and commercial bribery by multinational companies is widely known. As part of this campaign against bribery, the Chinese government has promulgated a number of new laws against corruption and bribery as well as lengthy and binding interpretations of existing laws. The Chinese state-controlled media is also full of reports of convictions of corrupt officials and hefty fines imposed on greedy multinationals trying to bribe their way to business success in China. Although these developments may indicate an increase in transparency in the enforcement climate against corruption and commercial bribery, ironically the crackdown on corruption has led to less transparency in China’s enforcement of its anti-bribery laws. The reason is that as cases of government corruption and commercial bribery become more important and the stakes become higher, the Communist Party believes that it must take a more hands on approach to these cases by directing their outcomes from behind the scenes. Since the Party controls all government enforcement authorities and the courts, the Party is able to dictate the outcome of cases in secrecy. As these cases have grown in number and importance, the role of the Party has also grown adding to the political intrigue, bargaining between rival factions of the Party, and the settling of old scores playing out behind the scenes in these cases in secretive Party proceedings. Once the Party makes a decision, it will then direct a public entity, a government enforcement authority or a court, on how to dispose of the case. But the real reasons for the disposition of the case by the Party are never revealed to the public or to the parties leading to less transparency in the enforcement of China’s anti-bribery laws.
Abstract TP396: Distinguishing Characteristics of Headache in Non-Traumatic Subarachnoid Hemorrhage

Subarachnoid hemorrhage (SAH) is a life-threatening emergency that is frequently missed due to its varied and often subtle presentation. The most common presentation of SAH is with a severe headach...
Decoding Native Cortical Representations for Flexion and Extension at Upper Limb Joints Using Electrocorticography

Brain–machine interface (BMI) researchers have traditionally focused on modeling endpoint reaching tasks to provide the control of neurally driven prosthetic arms. Most previous research has focused on achieving an endpoint control through a Cartesian-coordinate-centered approach. However, a joint-centered approach could potentially be used to intuitively control a wide range of limb movements. We systematically investigated the feasibility of discriminating between flexion and extension of different upper limb joints using electrocorticography(ECoG) recordings from sensorimotor cortex. Four subjects implanted with macro-ECoG (10-mm spacing), high-density ECoG (5-mm spacing), and/or micro-ECoG arrays (0.9-mm spacing and 4 mm $\times $ 4 mm coverage), performed randomly cued flexions or extensions of the fingers, wrist, or elbow contralateral to the implanted hemisphere. We trained a linear model to classify six movements using averaged high-gamma power (70–110 Hz) modulations at different latencies with respect to movement onset, and within a time interval restricted to flexion or extension at each joint. Offline decoding models for each subject classified these movements with accuracies of 62%–83%. Our results suggest that the widespread ECoG coverage of sensorimotor cortex could allow a whole limb BMI to sample native cortical representations in order to control flexion and extension at multiple joints.
Matters Order: The Role of Information Order on Implicit Impression Formation:

A classic finding in the person perception literature is that information order is an important factor in the impressions we form of others. But how does order influence the formation of implicit e...
No honor among thieves: personal and peer deviance as explanations of online identity fraud victimization

The current study examines identity fraud victimization within a college student sample. Concepts from the lifestyle-routine activity approach, specifically exposure and proximity to motivated offenders, as well as the personality trait of low self-control, are examined as potential explanations for identity fraud. The knock-on relationship between hacking and identity fraud is also of interest. Using data from a sample of college students at a Midwestern university in the U.S., and structural equation modeling techniques, the findings suggest that peer deviance, low self-control, and hacking victimization are directly related to identity fraud, whereas the relationship between personal deviance and identity fraud victimization operates indirectly through hacking. Overall, the results support lifestyle-routine activities and low self-control as theoretical explanations of identity fraud victimization.
Combination efficacy with MetMAb and erlotinib in a NSCLC tumor model highlight therapeutic opportunities for c-Met inhibitors in combination with EGFR inhibitors

1336 Crosstalk between EGFR and c-Met has been implicated in a number of biological systems. In tumors, interactions between these two pathways may affect tumor cell growth, survival, and response to treatment. Accordingly, MET gene amplification has been shown to be a mechanism of resistance to EGFR inhibitors in non-small cell lung cancer (NSCLC). Our data indicate that combining c-Met and EGFR antagonists may be an effective treatment for NSCLC beyond instances of acquired resistance. First, EGFR and c-Met show a significant overlap of expression in primary NSCLC specimens and cell lines. Second, EGFR and c-Met can co-associate and their activation in several tumor cell lines appears to be linked. In NSCLC lines lacking EGFR mutation or constitutive activity, HGF stimulation can induce activation of EGFR. Inhibition of c-Met in cell lines with elevated levels of c-Met protein decreases basal phosphorylation of EGFR. Conversely, in lines overexpressing or harboring mutations in EGFR, high EGFR activity can drive c-Met phosphorylation and pathway activation. Inhibition of EGFR in these lines results in rapid de-phosphorylation of c-Met and other downstream mediators, including trans-activation of ErbB3 resulting in PI-3K and Akt activity. Third, modulation of c-Met activity can inversely affect response to erlotinib in HGF-responsive cells. More specifically, c-Met activation protects cells from erlotinib-induced apoptosis, and c-Met inhibition can restore erlotinib responsiveness. Fourth, combinations of c-Met and EGFR inhibitors in xenograft tumor models show enhanced tumor growth inhibition beyond that observed with either agent alone. An example of this is the NCI-H596 NSCLC xenograft tumor model that shows robust enhancement of growth in human HGF-Tg-SCID mice, indicating that this tumor model is strongly HGF-driven. Despite robust inhibition of other HGF-driven tumor models in HGF-Tg-SCID mice by the monovalent anti-c-Met antibody, MetMAb, treatment of HGF-Tg-SCID mice harboring established NCI-H596 tumors with MetMAb resulted in ~65% tumor inhibition, indicating that blockade of HGF by MetMAb is not sufficient for full tumor inhibition in established tumors. Treatment of NCI-H596 xenograft tumors with erlotinib alone had minimal effects. However, combination of MetMAb plus erlotinib very potently inhibited tumor growth ~90%, indicating that EGFR plays a major role in tumor survival and growth in the face of potent c-Met inhibition in this model. Taken together these data indicate that simultaneous targeting c-Met and EGFR may have a great impact on NSCLC tumors, where co-activation of these receptor pathways is frequently observed.
Lower Vitamin B12 Level at Multiple System Atrophy Diagnosis Is Associated With Shorter Survival

BACKGROUND Multiple system atrophy (MSA) is a neurodegenerative disorder from α-synuclein aggregation. in vitro studies suggest vitamin B12 may interrupt α-synuclein-mediated neurodegeneration. The objective of this study was to determine whether serum vitamin B12 level at MSA diagnosis is associated with survival. METHODS One hundred eighty-two MSA patients evaluated at Mayo Clinic with vitamin B12 testing were studied. We determined the risk of death in relationship to serum vitamin B12 levels at MSA diagnosis, adjusting for predictors of poor survival. RESULTS Predictors of shorter survival included vitamin B12 < 367 ng/L (HR, 1.8; 95% CI, 1.3-2.7), falls within 3 years of MSA diagnosis (HR, 1.6; 95% CI, 1.1-2.3), bladder symptoms (HR, 1.6; 95% CI, 1.0-2.6), urinary catheter requirement (HR, 1.7; 95% CI, 1.0-2.8), male sex (HR, 1.4; 95% CI, 1.0-2.0), and MSA-P subtype (HR, 1.5; 95% CI, 1.0-2.0). CONCLUSIONS Low vitamin B12 levels are associated with shorter survival in MSA. Additional studies to explore this observation and assess the potential role of vitamin B12 as a modifiable survival factor are needed. © 2020 International Parkinson and Movement Disorder Society.
Posterior reversible encephalopathy syndrome (PRES) as a neurological association in severe Covid-19.

• PRES is potentially a complication of severe SARS-CoV-2 infection. • Consider PRES in COVID-19 patients with altered mentation. • Consider tight blood pressure control in ventilated patients with COVID-19. • Hypertensive encephalopathy may prolong ventilator times in COVID-19 patients.
Charged with Instability: Are Paternal Arrests and Criminal Charges Enough to Shake the Marital Stability of American Couples?:

With the growing rate of divorce, increasing efforts are being made to identify the factors that contribute to relationship dissolution for many American couples. One commonly noted, and particular...
Teachers’ Psychological Distress in North Carolina: An Analysis of Urban versus Non-Urban School Districts:

Teachers experience a great deal of psychological distress. However, there is a gap in the literature concerning the difference between the distress of teachers working in urban schools versus thos...
Terror Management Theory and the COVID-19 Pandemic

Terror management theory is focused on the role that awareness of death plays in diverse aspects of life. Here, we discuss the theory’s implications for understanding the widely varying ways in whi...