cssi/SciSciGPT-SciSciNet huggingface dataset:
Rate of degradation of muscle proteins following localized radiolabeling with N-ethylmaleimide in vivo

Abstract The sulfhydryl reagent, N -ethylmaleimide (MalNEt), has been employed to radiolabel rat skeletal muscle protein in vivo . Approximately 25% of the recovered label was in the injected gastrocnemius muscle and was found to be localized with the highest specific radioactivity at the point of injection, decreasing with increasing distance from the point of injection. Hydrolysis of the labeled protein fractions followed by amino acid analysis showed that a majority of the radioactivity comigrated with S -(2-succinyl) cysteine. Significant amounts of succinyl lysine and a third derivative were also found. Electrophoresis of MalNEt-labeled proteins through polyacrylamide gels in the presence of sodium dodecyl sulfate and mercaptoethanol revealed that all muscle proteins are labeled in vivo except one with an apparent molecular weight of 60,000. The injected muscle remained functional and displayed no weight changes. However, the radiolabel disappeared rapidly: Half-lives of 0.9, 0.8, and 1.2 days were observed for homogenate, myofibrillar, and extract fractions, respectively. Additional experiments with labeled leucine and unlabeled MalNEt suggested that the unexpectedly short half-lives may not be a result of stimulation of degradation by MalNEt.
Electron microscopy of cestode calcareous corpuscle formation.

Abstract The formation of calcareous corpuscles in the common cat tapeworm, Taenia taeniaeformis , is described. The corpuscle forms in a cytoplasmic cavity, and the corpuscle-forming cell appears to expend itself in the production of one corpuscle. Two corpuscular components were recognized: a homogeneous matrix that may correspond to one of the organic moieties known to be present in corpuscles, and a granular substance that may represent inorganic material. The corpuscle enlarges by the accretion of these two components in concentric layers with progressive compression of the surrounding cytoplasm.
Magnetic Resonance and Susceptibility of Several Ilmenite Powders

Magnetic susceptibility, paramagnetic resonance, and antiferromagnetic resonance have been measured in MnTi${\mathrm{O}}_{3}$, FeTi${\mathrm{O}}_{3}$, CoTi${\mathrm{O}}_{3}$, and NiTi${\mathrm{O}}_{3}$. N\'eel temperatures ${T}_{N}$ of 65, 56, 37, and 23\ifmmode\pm\else\textpm\fi{}2\ifmmode^\circ\else\textdegree\fi{}K, respectively, have been measured. The molar susceptibilities appear to obey a Curie Weiss law with ${C}_{m}=4.36,3.37,3.72, \mathrm{and} 1.24$\ifmmode^\circ\else\textdegree\fi{}K, and with paramagnetic Curie temperatures ${\ensuremath{\Theta}}_{p}=\ensuremath{-}219,+32,,\ensuremath{-}9.3, \mathrm{and} \ensuremath{-}11$\ifmmode^\circ\else\textdegree\fi{}K, respectively. The effective spectroscopic splitting factors consistent with this law and with paramagnetic resonance are ${g}_{\mathrm{eff}}=2.01,2.13,2.83,2.22\ifmmode\pm\else\textpm\fi{}0.01$. The susceptibility of MnTi${\mathrm{O}}_{3}$ exhibits a broad peak near 100\ifmmode^\circ\else\textdegree\fi{}K rather than a well-defined peak at ${T}_{N}$. No antiferromagnetic resonance was observed in FeTi${\mathrm{O}}_{3}$, and no paramagnetic resonance was observed in FeTi${\mathrm{O}}_{3}$ or CoTi${\mathrm{O}}_{3}$. The antiferromagnetic resonant frequencies, extrapolated to 0\ifmmode^\circ\else\textdegree\fi{}K, are 156, 145, and 187 kMc/sec for MnTi${\mathrm{O}}_{3}$, CoTi${\mathrm{O}}_{3}$, and NiTi${\mathrm{O}}_{3}$, respectively. A low-frequency mode of 19.1 kMc/sec was also detected in NiTi${\mathrm{O}}_{3}$. In the system ${\mathrm{Mn}}_{1\ensuremath{-}x}{\mathrm{Mg}}_{x}\mathrm{Ti}{\mathrm{O}}_{3}$, both ${\ensuremath{\omega}}_{R}$ and ${T}_{N}$ decrease roughly linearly with $x$ in the range $0lxl0.075$.
Cuticular lesions induced in grass shrimp exposed to hexavalent chromium

Abstract Adult grass shrimp were exposed to four concentrations (0.5, 1.0, 2.0 and 4.0 ppm) of hexavalent chromium for 28 days. At the end of the exposure period, over 50% of the surviving shrimp possessed cuticular lesions that had many of the gross characteristics of “shell disease.” These lesions were usually associated with articulations of the appendages and abdomen. Furthermore, it was found that at increasing levels of chromium exposure, there was a proportionate increase in the loss of limbs such that nearly 50% of the limbs were lost in grass shrimp exposed to the highest test concentration of chromium. Histological and ultrastructural examination of numerous lesions demonstrated a range of degenerative features within the subcuticular epithelium that included cytoplasmic vacuolization, mitochondrial swelling, chromatin emargination, and the presence of unusual nuclear inclusions that appear to indicate direct chromium toxicity. Additionally, a marked retardation in new epicuticle and exocuticle formation was observed in viable tissues associated with lesions in late premolt shrimp. It is proposed that chromium interferes with the normal functions of subcuticular epithelium, particularly cuticle formation, and subsequently causes structural weaknesses or perforations to develop in the cuticle of newly moted shrimp. Because of these chromium-induced exoskeletal deficiencies, a viaduct for pathogenic organisms (e.g., bacteria) and direct chromium influx is formed that perpetuates lesion development.
Permeability of medullary nephron segments to urea and water: Effect of vasopressin

Permeability of medullary nephron segments to urea and water: Effect of vasopressin. High papillary urea concentrations are necessary for the formation of maximally concentrated urine, while low papillary urea concentrations are associated with less concentrated urine. In the present studies we examined the membrane characteristics that are important in determining the medullary urea concentration profiles. Using isolated segments of rabbit nephrons perfused in vitro , we measured the diffusional urea and water permeability in the medullary thick ascending limb of Henle (MTALH), the outer medullary collecting duct (MCD) and the papillary collecting duct (PCD), in the presence and absence of antidiuretic hormone (ADH). Segments of MTALH and MCD were essentially impermeant to 14 C-urea. This degree of impermeability was maintained both with or without ADH. The urea permeability (× 10 -5 cm sec -1 ) of the PCD was moderate (2.2± 0.3 without ADH, 2.4± 0.6 with ADH). Diffusional water permeability (× 10 -5 cm sec -1 ) of the MTALH was low both with and without ADH; but the diffusional water permeability of the PCD increased from 39.9 ± 7.6 to 56.9 ± 8.6 (P Permeabilite a l'uree et l'eau des segments medullaires des nephrons: Effet de la vasopressine. Des concentrations papillaires d'uree elevees sont necessaires a la formation d'une urine concentree de facon maximale alors que les concentrations faibles d'uree sont contemporaines d'une concentration urinaire inferieure. En utilisant des segments de nephrons de lapins perfuses in vitro nous avons mesure la permeabilite de diffusion a l'uree et a l'eau de la partie medullaire de la branche ascendante large de l'anse de Henle (MTALH), du canal collecteur medullaire externe (MCD) et du canal collecteur papillaire (PCD) en presence et en l'absence d'hormone antidiuretique (ADH). Les segments de MTALH et MCD sont impermeants a l'uree 14 C. Ce degre d'impermeabilite est maintenu aussi bien avec que sans ADH. La permeabilite a l'uree (× 10 -5 cm sec -1 ) de PCD est moderee (2,2 ± 0,3 sans ADH, 2,4 ± 0,6 avec ADH). La permeabilite de diffusion a l'eau (× 10 -5 cm sec -1 ) de MTALH est faible a la fois en presence et en l'absence d'ADH mais la permeabilite de diffusion a l'eau du PCD augmente de 39,9 ± 7,6 a 56,9 ± 8,6 (P
Summary of Presentations from the 46th Annual Meeting of the American Society of Clinical Oncology (2010): Focus on Supportive Care Issues Related to Lung Cancer

Background: Patients with advanced cancer, particularly of the lung, frequently experience deteriorating physical health. Supportive care measures help ensure optimal quality of life during difficult psychologic and social situations. Research in the area of supportive care in patients with cancer should be made a priority. Methods: This review summarizes the findings from selected supportive care studies presented at the recently concluded 46 th annual meeting of the American Society of Clinical Oncology. Discussion: Topics discussed include the use of a single dose of fosaprepitant for prevention of chemotherapy-induced nausea and vomiting, statins to lower the incidence of venous thromboembolic events, fentanyl pectin nasal spray for cancer-related pain, and a closer look at the utilization of complementary and alternative medicine in patients with cancer.
Exposure of anesthesia providers in recovery from substance abuse to potential triggering agents.

Abstract Study Objective To determine the experience, attitudes, and opinions of anesthesia providers in recovery from addiction to anesthetic agents, who subsequently undergo surgery or who require opioid analgesics for injuries or other conditions. Design Survey instrument. Setting Academic medical center. Subjects Physicians and nurse-anesthetists in recovery in the United States. Measurements A link to a survey was posted on the Anesthetists in Recovery website on January 17, 2010 and allowed to remain active for a period of one week. The survey also was distributed via email to recovering anesthesiologists in a "snowball sampling" method. Completed surveys were reviewed, and data were compiled using Survey Monkey, with categorical variables described as frequencies and percentages. Main Results A total of 30 surveys were returned, with 27 (90%) reporting a history of abusing anesthetics or drugs commonly found in the work environment, and 19 (65.5%) reporting abuse of recreational drugs and drugs used during the administration of anesthesia. Twenty-eight (93%) respondents reported finding themselves in a situation that necessitated they receive their former drug of choice for legitimate medical reasons while in recovery. Conclusions Anesthesia care providers in recovery from addiction to anesthetic agents may undergo subsequent exposure to these agents due to medical necessity. Participation in a program of recovery with support from family members may decrease the risk of relapse but does not eliminate it.
Compact phase-shifted Sagnac interferometer for ultrasound detection

A compact fibre, phase-shifted Sagnac interferometer for ultrasound detection has been developed. The interferometer is a truly path-matched device, and therefore requires no path stabilization or heterodyning. It is a less expensive and more robust alternative to the heterodyne or path-stabilized Michelson interferometer. The device provides high spatial resolution of ultrasonic detection. It has been used in conjunction with conventional piezoelectric transducers (PZT) to detect Rayleigh and Lamb waves and to image a crack in a thin plate, rivet cracks in riveted plates, and for ultrasonic beam profiling.
A Fresh Look at the Index to Current Urban Documents and the Urban Documents Microfiche Collection

Need information on programs for homeless persons? On policies and costs for treating persons with AIDS? On groundwater contamination? Waterfront development? Rent control? How about requests for extensive narrative and statistical information on a distant community or metropolitan region? The Index to Current Urban Documents and its accompanying Urban Documents Microfiche Collection are excellent resources for these types of questions. Unfortunately, many libraries that subscribe to the index and microfiche collection fail to use them. In fact, underuse of these resources is probably the norm in most libraries. In a 1986 study of northern Illinois public libraries identified as receiving requests for local government information at least biweekly, none of the librarians interviewed reported having used the Index to Current Urban Documents.
βB1-crystallin: thermodynamic profiles of molecular interactions.

Background β-Crystallins are structural proteins maintaining eye lens transparency and opacification. Previous work demonstrated that dimerization of both βA3 and βB2 crystallins (βA3 and βB2) involves endothermic enthalpy of association (∼8 kcal/mol) mediated by hydrophobic interactions. Methodology/Principal Findings Thermodynamic profiles of the associations of dimeric βA3 and βB1 and tetrameric βB1/βA3 were measured using sedimentation equilibrium. The homo- and heteromolecular associations of βB1 crystallin are dominated by exothermic enthalpy (−13.3 and −24.5 kcal/mol, respectively). Conclusions/Significance Global thermodynamics of βB1 interactions suggest a role in the formation of stable protein complexes in the lens via specific van der Waals contacts, hydrogen bonds and salt bridges whereas those β-crystallins which associate by predominately hydrophobic forces participate in a weaker protein associations.
Spin-orbit interaction determined by antilocalization in an InSb quantum well

The magnetoresistance at temperatures below 20 K in an $n\text{-InSb}/{\text{In}}_{0.85}{\text{Al}}_{0.15}\text{Sb}$ two-dimensional electron system is studied and described in terms of antilocalization due to quantum interference under strong spin-orbit interaction. The spin-orbit interaction coefficients are extracted by fitting the magnetoresistance data to an antilocalization theory distinguishing the Rashba and Dresselhaus contributions. A good agreement between magnetoresistance data and theory suggests a Rashba coefficient $|\ensuremath{\alpha}|\ensuremath{\approx}0.03\text{ }\text{eV}\text{ }\text{\AA{}}$ and a Dresselhaus coefficient $\ensuremath{\gamma}\ensuremath{\approx}490\text{ }\text{eV}\text{ }{\text{\AA{}}}^{3}$. A strong contribution from the Dresselhaus term leads to pronounced anisotropy in the energy splitting induced by spin-orbit interaction in the two-dimensional electron dispersion.
Multiple Arousal Theory and Daily-Life Electrodermal Activity Asymmetry

Using “big data” from sensors worn continuously outside the lab, researchers have observed patterns of objective physiology that challenge some of the long-standing theoretical concepts of emotion ...
Role of Storms in Development of Ancient Marine Ridge and Swale System: ABSTRACT

Upper Jurassic (Oxfordian) sediments of Montana and Wyoming were deposited on a broad, shallow-marine shelf. Facies relations demonstrate that much of this shelf was characterized by a series of sand ridges separated by muddy swales. Ridges attain a thickness of about 12 m, an axial length of at least several kilometers, and a width measured perpendicular to crest less than 1 km. The crests of individual ridges are not parallel with one another or with the paleoshoreline. Analyses of directional features reveal multidirectional current vectors within individual ridges. The vertical sequence of internal sedimentary structures reveals that the ridges were constructed in distinct episodes, during which current flow was at least in the upper low-flow regime. Each episode is r presented in the rocks by a unique style, scale, and vector of cross stratification. Storms are considered to be the main process responsible for the buildup of ridges, individual storms being responsible for each of the sedimentation units of which the ridges are composed. As sand supply, storm intensity, and wind direction varied from storm to storm, so the style, scale, and vectors of the resultant cross stratification varied. Fair-weather processes were minor factors in the development of the ridge and swale system. End_of_Article - Last_Page 775------------
Isozymes of l(+) LDH in Hymenolepis diminuta

Abstract 1. 1. Two isozymes of l (+) lactate dehydrogenase in the parasitic helminth Hymenolepis diminuta (Cestoda) are demonstrated by starch-gel electrophoresis. 2. 2. LDH patterns exhibit tissue specificity and ontogenetic changes. LDH-A activity occurs in all tissues of the adult worm, but LDH-B activity is restricted to ovarian tissues.
Dissociation between ACTH and beta endorphin immunoreactivity in cells of the rat pituitary gland.

Abstract We have studied by immunoperoxidase histology the pituitary gland of the rat with rabbit antisera to unconjugated (human) beta endorphin and to ACTH 1–24. All of the intermediate lobe cells were positive with both antisera. ACTH- and beta endorphin-positive cells were present in the anterior lobe but there was considerable dissociation between them and the latter were more numerous. These results suggest that there can be differential processing of the 31K precursor by pituitary cells.
The mechanism of the biologic activity of a series of nitroolefins

Abstract The relation of sulfhydryl (SH) reactivity to oxygen uptake inhibition by a series of molluscicidal β-nitrostyrene (BNS) derivatives was investigated. Inhibition of O 2 uptake was significantly ( P 2 uptake inhibition by members of this series was associated with reduced tissue SH content. Preincubation of homogenates with cysteine antagonized the effect of BNS on O 2 uptake. Saturation of the BNS nitroolefinic bond resulted in a product (1-phenyl, 2-nitroethane) with diminished ability to inhibit O 2 uptake as well as reduction of SH reactivity. These data indicated that the effect of the BNS derivative on O 2 uptake was mediated through an interaction between BNS and tissue SH material.
The Role of γ-Al2O3 Single Crystal Support to Pt Nanoparticles Construction

Here we report the preparation of a model Pt/γ-Al2O3 catalyst and its characterization by a cross-sectional high-resolution electron microscopy (XHREM) method. Pt/γ-Al2O3 is the most important technologically-relevant heterogeneous catalyst in the fuel cell, oil refining and chemical industries. The nanoparticle/support interactions, particularly the role of their interface, play a key role in the 3-dimensional (3D) particle shape, surface morphology and sintering behaviors of catalyst nanoparticles (NPs) which determine the heterogeneous catalysts’ chemical properties. Experimental measurements [1] and theoretical simulations [2] were initiated to quantitatively study the interfacial atomic and electronic structure and adhesion energy between the NPs and their support. Previous investigators have used single crystal oxide supports to resolve the nanoparticle/support structure and shape relations that can be directly compared to the theoretical simulations [2]. However, commercial γ-Al2O3 is polycrystalline and irregular in shape; hence, our aim is to create a single crystal γ-Al2O3 thin film in order to build up a model system to solve the structural and electronic relations between the Pt and γ-Al2O3 support, and compare our experimental results with theoretical predictions.
Measurement of infarct size using single photon emission computed tomography and technetium-99m pyrophosphate: A description of the method and comparison with patient prognosis

The application of dual tracer transaxial emission computed tomography of the heart was studied with use of technetium-99m pyrophosphate and technetium-99m-labeled red blood cells for measuring infarct size in 20 patients with acute myocardial infarction and 10 without infarction. Imaging was performed with a standard gamma camera and with a multidetector transaxial emission computed tomographic body scanner 3 hours after injection of technetium-99m pyrophosphate. Immediately after the scanning procedure, technetium-99m pertechnetate was injected to label red blood cells, and the scanning protocol was repeated. Technetium-99m pyrophosphate was detected in the anterior wall with involvement of the interventricular septum or lateral wall in patients with electrocardiographic criteria for anterior infarction, whereas uptake was detected in the diaphragmatic left ventricular wall with involvement of the posterior, posteroseptal or posterolateral left ventricle or of the right ventricle in patients with electrocardiographic criteria for inferior or posterior infarction. Infarct size measured from transaxial images ranged from 14.0 to 117.0 g in weight. There was a direct relation between infarct size and patient prognosis in that, of the 13 patients with infarct greater than 40 g, 11 (85 percent) had complications, whereas only 2 (29 percent) of 7 patients with an infarct less than 40 g had complications during a follow-up period averaging 17.8 months (p less than 0.05).
Localization of actin and tubulin in developing and adult mammalian photoreceptors.

In order to define cytoskeletal domains of the mammalian photoreceptor, actin and tubulin were localized in adult retinae of mouse and human. For light-microscopic localization, actin was labeled using fluorescent phalloidin or monoclonal antibodies against actin, and tubulin was labeled using monoclonal antibodies against alpha- and beta-tubulin in an immunocytochemical method. Actin and tubulin were also localized by ultrastructural immunocytochemistry in the mouse. Filamentous actin was present in the retina at the outer limiting membrane and in synaptic terminals, especially of the cones, while globular actin was observed additionally in the inner segments. Muller cell cytoplasm and apical microvilli at the outer limiting membrane were also labeled for filamentous actin. Alpha- and beta-tubulin were evident throughout the photoreceptors, including the inner segments, but not in the synaptic terminals or at the outer limiting membrane. In the early postnatal retina of mouse, actin and tubulin were present at the ventricular surface. This pattern changed as photoreceptors fully elongated and as synaptogenesis occurred in the outer plexiform layer.
Multilingual Grammar Resources in Multilingual Application Development

Grammar development makes up a large part of the multilingual rule-based application development cycle. One way to decrease the required grammar development efforts is to base the systems on multilingual grammar resources. This paper presents a detailed description of a parametrization mechanism used for building multilingual grammar rules. We show how these rules, which had originally been designed and developed for typologically different languages (English, Japanese and Finnish) are applied to a new language (Greek). The developed shared grammar system has been implemented for a domain specific speech-to-speech translation application. A majority of these rules (54%) are shared amongst the four languages, 75% of the rules are shared for at least two languages. The main benefit of the described approach is shorter development cycles for new system languages.
Enhancement of humoral immune response against human lung elastin peptides.

When guinea pigs instead of rabbits were used as the host animals, 8–16 times higher antibody titers against human lung elastin peptides were produced with only 1/20 the amount of antigen per unit body weight. This corresponds to a 200-fold enhancement of the immune response.
Isolation and extirpations in wildlife reserves

Abstract Recent evidence implies that reserve faunal communities may experience species depletion as a result of isolation from contiguous gene pools. Although we could find no species-area relation between reserve size and the number of extant large mammal species in 13 East African savanna reserves, certain tenets of biogeographic theory still apply. Available data from one such area reveal four extirpations in recent times. This may support the hypothesis that isolated reserves may be experiencing species depletion due to isolation from surrounding natural habitat.
The Relationships Between Population Density of Meloidogyne Incognita and Nicotine Content of Tobacco1)

Seedlings of Meloidogyne incognita resistant (NC 95) and susceptible (McNair 30) tobacco cultivars were grown in 15 cm clay pots containing steamed soil infested with 0, 4, 16, and 64 eggs of M. incognita per 1.5 cc soil. Dry root weight of NC 95 and McNair 30 decreased from 22 g to 15 g and from 24 g to 0.8 g, respectively, as nematode density was increased from 0 to 64 eggs per 1.5 cc soil. Sixteen amino acids, including precursors for nicotine, and nicotine increased significantly in roots of NC 95 and McNair 30 as nematode density was increased. Nicotine content increased 77% and 56% in roots of NC 95 and McNair 30 respectively as the initial nematode density was increased from 0 to 64 eggs per 1.5 cc soil. Leaf-nicotine content increased from 0.9% to 1.5% in NC 95, and decreased from 0.8% to 0.7% in McNair 30 as nematode density was increased from 0 to 64 eggs per 1.5 cc soil. As nematode density was increased, roots of NC 95 were not damaged significantly, and higher nicotine content in infected roots resulted in higher nicotine levels in the leaves because nicotine translocation apparently was not restricted. In McNair 30 severe root damage by increased nematode density probably decreased nicotine movement to vegetative organs.
Teaching physical evaluation and physical diagnosis in a hospital setting

Course content and the experience of teaching physical evaluation and physical diagnosis in a hospital are described. At the present time, physical evaluation and physical diagnosis are being incorporated in the educational curriculum of the dental student and the dental resident. Problems related to the implementation of this teaching material and its importance in reinforcing the total patient care concept are discussed.
Core Competencies in Hospital Pharmacy — Medication Order Review:

The next several Director's Forum articles will focus on core practices or competencies in hospital pharmacy practice. This series of articles will discuss the key fundamentals, resources, challenges, and opportunities associated with drug dispensing. Future core competency forums will include discussions on medication ordering, intravenous admixtures, data analysis, and regulatory requirements.In Director's Forum, we hope to answer key questions that pharmacy directors face and provide others with information to foster growth in pharmacy leadership. The articles in this column will build on one another and, when put together, will serve as a “tool kit” to develop patient-centered pharmacy services in hospitals of all sizes. Examples of topics in future Director's Forums will include establishing clinical service priorities, justifying clinical pharmacist positions, implementing a patient safety program, and budgeting for patient-centered services.
Beta-blocker utilization and outcomes in patients receiving cardiac resynchronization therapy.

Introduction Optimal pharmacologic therapy (OPT) is considered a prerequisite to consideration for cardiac resynchronization therapy (CRT). Hypothesis Medications such as beta-blockers (BB) with demonstrated benefit in heart failure (HF) are being under utilized in patients receiving CRT. Methods Consecutive patients receiving a CRT-capable defibrillator in 2004 at a tertiary care center for standard indications were studied. Clinical data and medications upon hospital discharge were recorded. Patients were followed for endpoints of death or transplantation. Results Of 177 patients receiving a CRT device, 129 (73%) received BB therapy (group 1). Of the 48 patients not on BBs (group 2), relative contraindications were documented in 21 (allergy in 3, hypotension or inotrope-dependent HF in 4, chronic obstructive pulmonary disease [COPD] in 6, and amiodarone therapy in 8). The remaining 27 patients (group 3) did not receive BB therapy despite absence of documented justification. Compared to group 1, group 3 patients were similar in terms of clinical characteristics and angiotensin-converting enzyme inhibitor (ACEI) use, but were less likely to be on statin therapy. Patients were followed for a mean of 19.9 ± 9.2 mo. After adjusting for age, QRS duration, creatinine, left ventricular ejection fraction (LVEF), statin use, and presence of ischemic HF etiology, patients not receiving BB therapy in the absence of contraindication had increased risk of death or transplantation (odds ratio [OR]: 3.1, p = 0.043). Conclusions Absence of BB therapy appears to be independently associated with poor outcome in CRT recipients. These results suggest that a crucial component of OPT may be underutilized in a population of HF patients receiving CRT. Copyright © 2009 Wiley Periodicals, Inc.
Community detection-based features for sequence classification

Machine learning algorithms are widely used to annotate biological sequences. Most learning algorithms require data to be represented using a vector of features. In the absence of biologically informative features, k-mers generated using the sliding window-based approach are commonly used to represent biological sequences. However, the number of features generated using the sliding window-based approach increases exponentially with the length of the k-mer, k, and as a consequence, the computational time of the learning algorithms also increases. As an alternative to k-mers, we propose to use a community detection approach to identify informative features for sequence classification. The community detection approach is run on a network constructed based on k-mer similarity, and it has the advantage that class labels are not needed when constructing the network. It works by identifying sets of nodes that are densely connected when compared to other nodes of the network. Community detection approaches are computationally expensive, especially for large or densely connected networks. To address this challenge, we propose an efficient strategy that involves running the community detection approach on a set of samples, where each sample is a small subset of the total set of sequences. A set of features is obtained from each sample, and the union of all feature sets is used to represent sequences for classification purposes. Experimental results in both supervised and semi-supervised settings show that the features generated with the community detection approach are more informative than k-mers. Furthermore, we observe that running the community detection approach on a set of small samples of sequences produces better features as compared to running the community detection approach on a set of large samples of sequences.
Cadmium sulfide enhances solar cell efficiency

Abstract A thin layer of CdS of about 200 A enhances the solar conversion efficiency of CdS/CdTe solar cells from 8% to 15%. A similar enhancement of the efficiency is observed on other solar cells, based on CuInSe2 or similar compounds. The reason for this efficiency enhancement that is typical for CdS, but not observed with similar semiconductors, is briefly described. The technical and economical importance of these solar cells on the energy conversion market is summarized.
Spatial distribution of large-scale solar magnetic fields and their relation to the interplanetary magnetic field

The spatial organization of the observed photospheric magnetic field, as well as its relation to the polarity of the interplanetary field, have been studied using high resolution magnetograms from Kitt Peak National Observatory. Systematic patterns in the large scale field have been found to be due to contributions from both concentrated flux and more diffuse flux. It is not necessary to assume, as has often been done in previous studies, that there is a weak background solar magnetic field causing the large-scale patterns in the photosphere, although the existence of such a field cannot be excluded. The largest scale structures in the photosphere correspond to the expected pattern at the base of a warped heliomagnetic equator. The polarity of the photospheric field, determined on various spatial scales, correlates with the polarity of the interplanetary field, with the most significant correlation due to mid-latitude fields. However, because the interplanetary field is likely to be rooted in concentrated photospheric regions, rather than across an entire polarity region, both the strength and polarity of the field are important in determining the interplanetary field. Thus studies of the interplanetary field which are based on either instrumental or numerical averaging of fields in the solar photosphere are subject to serious inherent limitations. Analyses based on several spatial scales in the photosphere suggest that new flux in the interplanetary medium is often due to relatively small photospheric features which appear in the photosphere up to one month before they are manifest at the Earth. The evolution of the over-all photospheric pattern may be due to individual sub-patterns which have slightly different rotation properties and which alternate in their relative dominance of the interplanetary medium.
MODIFICATION OF THE INTRAUTERINE ASSAY METHOD FOR PROGESTERONE1

THE SEVERAL KNOWN ACTIONS of progesterone 2 on the uterus have naturally been II applied as criteria for testing the presence of the hormone in the animal body. Jl Several unique methods of bioassay have been proposed, each utilizing one or more of the varied phenomena of uterine progestational activity as its physiological basis. The action of progesterone on uterine motility has been suggested by Van Dyke and Chen (i) as a method of progesterone assay. The optimum amount to be tested is about 0.45 mg. of progesterone. Astwood (2) suggests a test for 0.50 to 1.0 mg. of progesterone by observing the decidual reaction in rats. Pincus and Werthessen (3) utilize as a criterion of a bioassay method the diameter of an ovum and ratio between the area of the epithelium and stroma of the rabbit's uterus.
Maximum likelihood estimation for a nearly random walk model

This paper proposes an effective reparameterization method for the maximum likelihood estimation of a nearly random walk ARIMA (1,1,1) model, an important case where standard method of locating the MLE is not satisfactory. This model is equivalent to the permanent and temporary components model that Fama &French (1988) and others used to capture the slow mean reversion behavior of stock prices. The reparameterization method we prppose for estimating the nearly cancelled AR and MA parameters performs satisfactorily. The exact likelihood function based on the transformed parameters is studied. We argue that the region of interest will get magnified and emphasized in the transformed space, thus making the search for MLE more thorough and effective. Substantiai simuiation evidences are provided to demonstrate the effectiveness of the method. The sample size requirement is critical and is discussed in details. For application, this method is applied to estimate a nearly random walk ARIMA (1,1,1) model for NYSE...
Calorimetric determinations on semibituminous coals using differential thermal analysis

Abstract The differential thermal method may be used on coals to show progressive reactions taking place during heating. Several variables must be considered in attempting to do quantitative work with coal. Further work is planned in which the thermopile will be eliminated and the single differential couple used with a DC amplifier.
1989 DEMOCRATIC MOVEMENT AND THE MAY FOURTH

L'A. essaie de tracer les liens entre le discours et les ideaux du Mouvement du quatre mai en Chine (1915-1922) et le Mouvement democratique des etudiants chinois de 1989
Perioperative characteristics and complications in obese patients undergoing anterior cervical fusion surgery

Abstract In the USA, obesity rates have significantly increased in the last 15 years. Mirroring this trend, a large proportion of patients undergoing spinal surgery are obese. Concern exists for increased complications due to surgical challenges posed by obese patients and their often-prevalent comorbidities. Studies have shown associations between body mass index (BMI) and perioperative complications in lumbar and thoracolumbar fusion surgeries; however, few studies have evaluated the impact of obesity on anterior cervical fusion surgery. As such, this study aimed to evaluate complications and perioperative characteristics in obese patients undergoing anterior cervical fusion. We queried medical records to identify patients with BMI >30 who underwent anterior cervical fusion surgery. A total of 69 patients were included and subdivided based on obesity class: Class 1 (BMI 30–35), Class 2 (BMI 35–40), and Class 3 (BMI >40). Subgroup analysis included comorbidities, diagnosis, procedure, levels treated, and length of hospital stay. Overall mean BMI was 35.1, mean age was 54.3 years, and 43 (63.3%) were men. Disc herniation was the most common diagnosis. Length of stay differed significantly among obesity subgroups (p = 0.02). Mean length of stay was 2.8, 3.5, and 4.0 days for Classes 1, 2, and 3, respectively. Three (4.3%) complications were observed, comprising of urinary tract infection, wound dehiscence, and neck hematoma. Complication rates by class were 5.5%, 0%, and 16.6% for Classes 1, 2, and 3, respectively (p = 0.17). We found that obese patients undergoing anterior cervical spine surgery experience relatively few complications. Hospital stay, however, appears to lengthen with increased BMI.
Application of nonperturbative quantum field theoretic methods to hadron-nucleus collisions: Background theory

Abstract An exposition of the background theory necessary for understanding the application of nonperturbative QFT methods (LSZ reduction formalism) to hadron-nucleus collisions, for example the derivation of pi-nucleus (πn) Low and Chew Low equations, is given. The many channels and complex targets on the one hand, and the quantized field interactions on the other, introduce subtleties not well covered in particle theory or potential scattering literature. By specializing the πn Low Equation we derive a “pi-nucleon Low equation in the nuclear medium.” The second main goal of the paper is to compare this equation with Dover and Lemmer's analogous equation arrived at by graphical arguments. This requires especially making explicit the analyticity properties left tacit in their work. In is concluded that the two are essentially different.
Case 6-5--1992. Anesthetic considerations for thoracoscopic procedures.

Cm! 1 A 77-year-old white man was admitted with a left-sided pleura1 effusion. His past history included prolonged asbestos exposure and heavy smoking. He presented with dyspnea and wcight 10s~. Physical examination revealed a thin individual with a large barrel-shaped chest. Preoperative pulmonary function tests showed an FEVt of 1.2 L. A computerized tomography scan showed multiple pleura1 plaques and areas of thickening, especially along the mediastinal pleura. Because of the patient’s poor pulmonary status, flexible bronchoscopy and thoracoscopy were scheduled. The planned perioperative monitoring included indwelling arterial pressure, end-tidal CO1 (ETCO& and peripheral oxygen saturation (SpO$ Anesthesia was induced with thiamylal, fentanyl, and vecuronium. The trachea was intubated initially with a single-lumen endotracheal tube for flexible fiberoptic bronchoscopy. Following this, a double-lumen right-sided endobronchial tube was inserted. After confirmatory chest auscultation and flexible bronchoscopy, the patient was positioned in the right lateral decubitus position. Anesthetic maintenance included fentanyl, vecuronium, and isoflurane/air/oxygen. One-lung ventilation (OLV) was maintained during the thoracoscopic procedure. During diagnostic thoracoscopy, the stopcock of the cannula was left open to room air to maintain an open pneumothorax. Air insufflation pressures of 10 to 11 mmHg were used to attain better visibility. Hemodynamic monitoring and management included special attention to changes in blood pressure, heart rate and rhythm, end-tidal CO2 because of the potential for arrhythmias, fa11 in venous return and cardiac output, gas embolism, and direct compression of cardiac structures. The surgical procedure involved multiple pleura1 biopsies and
Interfamily economic exchange: A function of culture or economics?

This study explores differences in inter-household exchange of goods and services in Anglo- and Mexican-American families controlling for income level and for ethnicity. The extent of such exchange, its perceived importance to the family's quality of life, satisfaction with the exchange, and the relation of persons in the exchange process are examined. Significant differences are found more often between higher income Anglo- and Mexican-Americans than between low-income families, both in the family providing goods and services for others and in the receipt of them. Higher income Mexican-American families are more likely than their Anglo- counterparts to exchange with relatives. Ethnic effects are more prevalent in higher income households than in low-income households. Economic effects are more predominant than ethnic effects.
Fabrication of 7.2% Efficient CZTSSe Solar Cells Using CZTS Nanocrystals

Earth abundant copper-zinc-tin-chalcogenide (CZTSSe) is an important class of material for the development of low cost and sustainable thin film solar cells. The fabrication of CZTSSe solar cells by selenization of CZTS nanocrystals is presented. By tuning the composition of the CZTS nanocrystals and developing a robust film coating method, a total area efficiency as high as 7.2% under AM 1.5 illumination and light soaking has been achieved.
The role of dermatologists in the delivery of occupational dermatologic care.

Skin diseases occurring as a result of workplace exposures remain among the most common occupational problems, especially in terms of the numbers of workers who experience a minor dermatitis episode at some time during their employment years. For most such episodes, the cause is a minor irritation that resolves quickly with avoidance or protective measures. Wet exposure, irritating chemicals, and friction are common trigger factors that the employee may recognize and self-treat. The first line of health provider intervention is often the company nurse or consultant primary care practitioner, either of whom is trained to manage minor skin injuries as well as minor dermatitis. This article focuses on the role of dermatologists in delivering diagnostic and therapeutic management of skin diseases thought to be related to workplace exposures or activities. Not every dermatologist is as effective as another in providing optimal information and advice that should accompany the direct clinical treatment of an occupational dermatosis. Which dermatologists should be sought out? Individual dermatologists who are affiliated with the American College of Occupational and Environmental Medicine and those who accept potential worker's compensation claims are more likely to be experienced and motivated in evaluation and treatment of occupational skin diseases. The American Academy of Dermatology, regional academic health center or medical school, and local medical society may be useful resources for identifying dermatologists who regularly see patients with an occupational dermatosis.
Barriers to College Access for Latino/a Adolescents: A Comparison of Theoretical Frameworks

A comprehensive description of barriers to college access for Latino/a adolescents is an important step toward improving educational outcomes. However, relevant scholarship on barriers has not been synthesized in a way that promotes coherent formulation of intervention strategies or constructive scholarly discussion. The goal of this article is to synthesize the barriers literature briefly as a basis for comparing and evaluating possible frameworks for addressing barriers. The bridging multiple worlds model, social capital theory, and social cognitive career theory are 3 possible frameworks for addressing barriers to college access for Latinos/as. Implications are given for future barriers research and programmatic interventions.
Luteal phase dynamics of follicle-stimulating and luteinizing hormones in obese and normal weight women

SummaryObjectives Female obesity is a state of relative hypogonadotrophic hypogonadism. The aim of this study is to examine gonadotrophin secretion and response to gonadotrophin-releasing hormone (GnRH) in the luteal phase of the menstrual cycle and to investigate the pharmacodynamics and pharmacokinetics of endogenous and exogenous luteinizing hormone (LH) in obese women. Design Participants underwent a luteal phase frequent blood sampling study. Endogenous LH pulsatility was observed, gonadotrophin-releasing hormone (GnRH) was given in two weight-based doses, and GnRH antagonist was administered followed by recombinant LH. Patients Regularly menstruating obese (n = 10) and normal weight (n = 10) women. Measurements Endogenous hypothalamic-pituitary function (as measured by LH pulsatility), pituitary sensitivity (GnRH-induced LH secretion), pharmacodynamics of endogenous LH and pharmacokinetics of exogenous LH were compared between the obese and normal weight groups. Results There were no statistically significant differences in endogenous LH pulsatility or pituitary responses to two weight-based doses of GnRH between the obese and normal weight women. There were no differences in the pharmacodynamics of endogenous LH or the pharmacokinetics of exogenous LH between the groups. FSH dynamics did not differ between the groups throughout the study. Conclusions The relative hypogonadotrophic hypogonadism of obesity cannot be explained by differences in LH and FSH luteal phase dynamics or differences in endogenous LH pharmacodynamics or exogenous LH pharmacokinetics.
Domains of the Glucocorticoid Receptor Involved in Specific and Nonspecific Deoxyribonucleic Acid Binding, Hormone Activation, and Transcriptional Enhancement

We have analyzed the domain structure of the mouse glucocorticoid receptor by expression of in vitro mutated receptor in COS-7 cells. The receptor consists of a core domain rich in Cys, Lys, and Arg amino acids which can bind specific DNA sequences (glucocorticoid response elements) and activate transcription. The activity of this centrally located domain is modulated by the activity of the other two domains. The N-terminal domain of the receptor plays a role in decreasing nonspecific DNA binding and may therefore improve the ability of the protein to discriminate between specific and nonspecific DNA binding sites. This activity maps to a small, highly acidic region of the N-terminal domain. The C-terminal domain of the receptor contains the glucocorticoid binding site and in addition represses the transcriptional activity of the receptor in the absence of hormone. Hormone binding relieves the repression allowing transcription activation. The Cterminal domain contains a short sequence conserved among ster...
The Limits of Demographic Categories and the Politics of the 2004 Presidential Election

This study looked at responses to the Iraq War in a nationwide sample of college students. The study focused mainly on the role of sex, religiosity, and the location of the school in a “red” or “blue” state. It also looked at a number of other psychological variables, including some related to cognitive competence. Support for the war was measured by an instrument comprising two independent factors—“patriotic militancy” and “internationalism.” As expected, support for the war in Iraq was significantly higher among students who considered themselves religiously involved than among students who rated themselves as more secular. Predicted sex differences in attitudes about the war were not found. However, several measures of cognitive competence including grade point average were significantly associated with less favorable attitudes toward the war. As expected from the election results later that year, students from “red” states were more supportive of the war than students from “blue” states. However, these effects appear to be due to a confound between religious affiliation and religiosity. The results are explained in terms of political rhetoric that focused on religious values as well as on the reduced importance of feminism as an ideological stance. They are discussed in terms of the need for a more social psychological analysis of political attitudes and behaviors that takes into account contextual factors and the transformation of demographic categories into meaningful psychological variables.