cssi/SciSciGPT-SciSciNet huggingface dataset:
Diffuse-interface polycrystal plasticity: expressing grain boundaries as geometrically necessary dislocations

The standard way of modeling plasticity in polycrystals is by using the crystal plasticity model for single crystals in each grain, and imposing suitable traction and slip boundary conditions across grain boundaries. In this fashion, the system is modeled as a collection of boundary-value problems with matching boundary conditions. In this paper, we develop a diffuse-interface crystal plasticity model for polycrystalline materials that results in a single boundary-value problem with a single crystal as the reference configuration. Using a multiplicative decomposition of the deformation gradient into lattice and plastic parts, i.e. F(X,t)=F L(X,t)F P(X,t), an initial stress-free polycrystal is constructed by imposing F L to be a piecewise constant rotation field R 0(X), and F P=R 0(X)T, thereby having F(X,0)=I, and zero elastic strain. This model serves as a precursor to higher order crystal plasticity models with grain boundary energy and evolution.
Forum Summarization Using Topic Models and Content-Metadata Sensitive Clustering.

The advent of the Internet and improvements in data sharing and storage, have resulted in an explosion of textual data. But, complete assimilation of such massive amounts of data in its raw form is a daunting task. Automated text mining methods such as text summarization present the user with a condensed version of data containing only key information. This is especially useful in the case of online user forums that contain a large number of posts spread out across several threads. Document summarization methods have been extensively studied and several methods have been developed in the recent past. This paper aims at developing a new method for automatic summarization of online forums by using topic models and content/metadata sensitive clustering.
Measurement of Progesterone Receptor in Human Renal Cell Carcinoma and Normal Renal Tissue

Progesterone receptor was measured in eight samples of renal cell carcinoma, nine samples of normal renal tissue, and one sample of melanoma tissue. Progesterone receptor was identified in all samples, with the exception of one renal cell carcinoma. Three patients, all with receptor-positive tumors, were treated with medroxyprogesterone acetate for metastatic disease. In one of these patients there was a partial objective response to treatment. Further research regarding progesterone receptor in renal cell carcinoma is indicated.
Side Effects of Systemic Cyclosporine in Patients Not Undergoing Transplantation

Abstract Twenty-six patients with ocular inflammatory disorders of presumed autoimmune origin were treated with oral cyclosporine. Cyclosporine is a potent T cell regulatory agent that has been utilized extensively in organ transplantation. In general, the patients in this study did not have chronic debilitating illnesses that are observed in organ transplant recipients, did not receive corticosterolds in addition to cyclosporine, and did not undergo any surgical procedure during their treatment. This study describes the observed adverse reactions in this group of patients not undergoing transplantation. The reported side effects of cyclosporine in organ transplant recipients have included nephrotoxicity, hepatotoxicity, infections, lymphoma, hirsutism, gingivitis, and central nervous system toxicity. Side effects were observed that were similar to those in previous reports, but the severity of the nephrotoxicity and hepatotoxicity appeared to be less. Nephrotoxicity occurred in eight patients and hepatotoxicity occurred in one patient. No lymphomas were seen. Hypertension and anemia each were observed in six patients. In addition, previously unreported effects of hyperuricemia, elevated sedimentation rate, and hidradenits were observed. However, the overall severity of the side effects did not seriously affect the usage of cyclosporine in the patients in this study. Cyclosporine may be useful in the treatment of other autoimmune diseases.
MR-Guided Aspiration Biopsy: Needle Design and Clinical Trials

Nonferrous needles of pure brass, titanium, or copper, and ferrous needles of different alloys of stainless steel were analyzed for the size, area, and distribution of the image artifact created when the needles were placed in a 0.6-T magnet. Results demonstrated that a stainless steel prototype needle (type 316) would be visible on magnetic resonance images and would provide an artifact similar to that seen in computed tomographic-guided biopsies. Further testing of this prototype included assessment of the effect on the artifact when changes were made in annealing properties, gauge, length, needle-tip geometry, pulse sequence, and orientation relative to the magnetic field. To date, three human liver biopsies have been successfully and safely performed using a stainless steel type 316 needle.
Control of Postbiopsy Renal Hemorrhage With Renal Artery Vasopressin Infusion

• Persistent, severe renal hemorrhage resulted from a diagnostic renal biopsy in a 19-year-old woman with chronic renal insufficiency. Infusion of vasopressin into the renal artery through an angiographic catheter produced prompt resolution of bleeding. This method has distinct advantages over surgical intervention or transcatheter embolization in the control of traumatic renal hemorrhage. ( Arch Intern Med 1984;144:1468-1469)
Fanconi Syndrome Associated With a Non-Ossifying Fibroma of Bone

A 20-year-old man presenting with osteomalacia was found to have the Fanconi syndrome, as evidenced by hypophosphatemia with hyperphosphaturia, glycosuria in the presence of normoglycemia, and generalized aminoaciduria. After removal of a non-ossifying fibroma of the left tibia, the renal tubular abnormalities promptly resolved with subsequent healing of the osteomalacia. A humoral factor released from the tumor may have caused the disorder in proximal renal tubular cell transport.
Congenital Absence of the Vagina

• Congenital absence of the vagina is the second leading cause of primary amenorrhea. Three patients had Mayer-Rokitansky-Kuster-Hauser syndrome or congenital absence of the vagina. We discuss the clinical, diagnostic, psychosocial, and therapeutic features of these patients and the syndrome. The lack of diagnosis until after puberty of this syndrome in many patients demonstrates the need for more careful genital examination in prepubertal and pubertal girls. (Am J Dis Child1983;137:669-671)
An Examination of the Relationship Between Postschool Outcomes and Autonomy, Psychological Empowerment, and Self-Realization:

This study examined, using data from the National Longitudinal Transition Study–2, the impact of constructs associated with self-determination (i.e., autonomy, self-realization, and psychological e...
Novel Transcriptional Activity and Extensive Allelic Imbalance in the Human MHC Region

The MHC region encodes HLA genes and is the most complex region in the human genome. The extensively polymorphic nature of the HLA hinders accurate localization and functional assessment of disease risk loci within this region. Using targeted capture sequencing and constructing individualized genomes for transcriptome alignment, we identified 908 novel transcripts within the human MHC region. These include 593 novel isoforms of known genes, 137 antisense strand RNAs, 119 novel long intergenic noncoding RNAs, and 5 transcripts of 3 novel putative protein-coding human endogenous retrovirus genes. We revealed allele-dependent expression imbalance involving 88% of all heterozygous transcribed single nucleotide polymorphisms throughout the MHC transcriptome. Among these variants, the genetic variant associated with Behcet's disease in the HLA-B/MICA region, which tags HLA-B*51, is within novel long intergenic noncoding RNA transcripts that are exclusively expressed from the haplotype with the protective but not the disease risk allele. Further, the transcriptome within the MHC region can be defined by 14 distinct coexpression clusters, with evidence of coregulation by unique transcription factors in at least 9 of these clusters. Our data suggest a very complex regulatory map of the human MHC, and can help uncover functional consequences of disease risk loci in this region.
Aqueous degradation in harvested medium voltage cables in nuclear power plants

For medium voltage (MV) power cables with voltages between 5 and 35 kV that provide power to emergency and safety support systems in nuclear power plants (NPPs), degradation and failure of cables due to water exposure has occurred. Systematic studies of current NPP MV cable systems are being carried out to determine and characterize cable-aging mechanisms and provide greater accuracy to models being developed to predict MV cable field performance to support existing cable aging management and monitoring programs. To validate models based on representative laboratory specimens, samples from harvested MV cable systems are being subjected to accelerated aging and degradation from humid conditions and submergence. Degradation will be characterized via partial discharge and voltage endurance testing of the cable and induced water tree growth in insulation. The technical approach to be used for the testing harvested MV cable samples is presented.
Eight-channel reconfigurable microring filters with tunable frequency, extinction ratio and bandwidth.

We demonstrate an eight-channel reconfigurable optical filter on a silicon chip. It consists of cascaded microring resonators and integrated compact heaters. With an embedded Mach-Zehnder (MZ) arm coupling to a microring resonator, the important parameters of a filter such as center frequency, extinction ratio and bandwidth can be controlled simultaneously for purposes of filtering, routing and spectral shaping. Thus our device could potentially be useful in dense wavelength division multiplexing (DWDM) and radio frequency arbitrary waveform generation (RFAWG). Multichannel filter response was successfully tuned to match the International Telecommunication Unit (ITU) grid with 50, 100 and 200GHz in channel spacing. Programmable channel selectivity was demonstrated by heating the MZ arm, and continuous adjustment of through-port extinction ratio from 0dB to 27dB was achieved. Meanwhile, the 3dB bandwidth in the drop port changed from 0.12nm to 0.16nm. The device had an ultra-compact footprint (1200μm×100μm) excluding the metal leads and contact pads, making it suitable for large scale integration.
Educational stability policy and the interplay between child welfare placements and school moves

Abstract Despite recent improvements in child welfare placement stability, youth in foster care still experience high rates of school moves. Although these findings are well documented in the literature, few studies have considered the interplay between child welfare placements and school moves. The purpose of this study was to determine the proportion of school moves that can be reduced through implementation of the educational stability provisions of the Fostering Connections to Success and Increasing Adoptions Act (FCA, 2008) and the Every Student Succeeds Act (ESSA, 2015), and to identify opportunities to minimize the number of transitions that children and youth in foster care experience. Findings indicate that implementation of the FCA and the ESSA is a critical, but partial, solution for ensuring the educational stability of students in foster care. This article provides an empirical rationale for states and local jurisdictions to incorporate non-regulatory recommendations in order to fill the gaps in federal regulations.
Poverty, rural population distribution and climate change

Our spatial analysis indicates that in 2000 over one third of the rural population in developing countries was located on less favored agricultural land and areas, which are constrained by biophysical conditions or poor market access. We examine whether these spatial distributions of rural population in 2000 influence subsequent changes in the rate of poverty from 2000 to 2012 in 83 developing countries. We find no evidence of a direct impact on changes in poverty, but there is a significant indirect impact via the elasticity of poverty reduction with respect to growth. If climate change leads to more people concentrated in these areas, or an increase in unfavorable agricultural regions, then the poverty-reducing impact of overall per capita income growth could be further weakened. Reducing poverty will require targeting rural populations in less favored lands and remote areas and encouraging out-migration.
Ramsey discounting calls for subtracting climate damages from economic growth rates

The Ramsey equation ties the utility discount rate and the elasticity of marginal utility of consumption together with per capita consumption growth rates to calculate consumption discount rates. For many applications, per capita consumption growth rates can be approximated with per capita output growth rates. That approximation does not work for climate change, which drives an ever-increasing and increasingly uncertain wedge between output and consumption growth. NAS (2017), in a central recommendation and illustrative example, conflates the two. The correct, consumption-based discounting method generally decreases consumption discount rates and, thus, increases the resulting Social Cost of Carbon Dioxide (SC-CO2).
Understanding Portfolio Efficiency with Conditioning Information

Contrary to the classic framework of passive strategies, if investors exploit return predictability through active strategies then there is a tension between the mean-variance frontiers that drive empirical work and the mean-variance preferences that are used in finance theory. We show that standard preferences choose portfolios on a frontier that has not been studied in the literature, develop new betas and Sharpe ratios to construct portfolio efficiency tests, and highlight some concerns with current empirical work. An empirical application to active strategies on stock portfolios sorted by size and book-to-market confirms the relevance of our theoretical results.
The Impact of the 2017 Act's Tax Rate Changes on Choice of Entity

The double tax imposed on the earnings of C corporations results in significant economic inefficiencies because of its effect on the choice of entity for conducting a business. All other items being equal, the double tax distorts taxpayers’ choice of entity because it motivates taxpayers to favor flow-through entities when they otherwise would not. The reduction in the corporate and individual tax rates in the legislation popularly known as the Tax Cuts and Jobs Act of 2017 (the “2017 Tax Act”) has been in part justified on the grounds that the rate changes would help achieve parity between effective tax rates imposed on C corporations and on flow-through entities.
Discussing Transgender Topics within Gay-Straight Alliances: Factors that Could Promote More Frequent Conversations.

Background: Gay-straight alliances (GSAs) have potential to facilitate conversations on transgender and gender-diversity issues among members. We examined how frequently GSA members discussed trans...
Simultaneous Pursuit of Discovery and Invention in the US Department of Energy

Abstract There is a sharp boundary between basic and applied research in the organizational structure of the US Department of Energy (DOE). In this work, we consider a branch of DOE that was designed to operate across this boundary: the Advanced Research Projects Agency – Energy (ARPA-E). We hypothesize that much of energy research cannot be neatly categorized as basic or applied and is more productive outside of the confines of the basic/applied dichotomy; ARPA-E gives us an opportunity to test that hypothesis. We construct a novel dataset of nearly 4000 extramural financial awards given by DOE in fiscal years 2010 through 2015, primarily to businesses and universities. We collect the early knowledge outputs of these awards from Web of Science and the United States Patent and Trademark Office. Compared to similar awards from other parts of DOE, ARPA-E awards are significantly more likely to jointly produce both a publication and a patent. ARPA-E has been highly productive in creating new technology, while also contributing new scientific knowledge. This observation points to the productive overlap of science and technology in energy research and, more generally, for mission-oriented research funding organizations.
Kindergarten Children's Executive Functions Predict Their Second-Grade Academic Achievement and Behavior.

Whether and to what extent kindergarten children's executive functions (EF) constitute promising targets of early intervention is currently unclear. This study examined whether kindergarten children's EF predicted their second-grade academic achievement and behavior. This was done using (a) a longitudinal and nationally representative sample (N = 8,920, Mage = 97.6 months), (b) multiple measures of EF, academic achievement, and behavior, and (c) extensive statistical control including for domain-specific and domain-general lagged dependent variables. All three measures of EF-working memory, cognitive flexibility, and inhibitory control-positively and significantly predicted reading, mathematics, and science achievement. In addition, inhibitory control negatively predicted both externalizing and internalizing problem behaviors. Children's EF constitute promising targets of experimentally evaluated interventions for increasing academic and behavioral functioning. [ABSTRACT FROM AUTHOR]
Minimal free resolutions of monomial ideals and of toric rings are supported on posets

We introduce the notion of a \emph{resolution supported on a poset}. When the poset is a CW-poset, i.e. the face poset of a regular CW-complex, we recover the notion of cellular resolution as introduced by Bayer and Sturmfels. Work of Reiner and Welker, and of Velasco, has shown that there are monomial ideals whose minimal free resolutions are not cellular, hence cannot be supported on any CW-poset. We show that for any monomial ideal there is a \emph{homology CW-poset} that supports a minimal free resolution of the ideal. This allows one to extend to every minimal resolution, essentially verbatim, techniques initially developed to study cellular resolutions. As two demonstrations of this process, we show that minimal resolutions of toric rings are supported on what we call toric hcw-posets, and we give a new combinatorial proof of a fundamental result of Miller on the relationship between Artininizations and Alexander duality of monomial ideals.
WEATHER ON THE GO: AN ASSESSMENT OF SMARTPHONE MOBILE WEATHER APPLICATIONS USE AMONG COLLEGE STUDENTS

AbstractMillions of people in the United States regularly acquire information from weather forecasts for a wide variety of reasons. The rapid growth in mobile device technology has created a conven...
Representing Graphs as Bag of Vertices and Partitions for Graph Classification

Graph classification is a difficult task because finding a good feature representation for graphs is challenging. Existing methods use topological metrics or local subgraphs as features, but the time complexity for finding discriminatory subgraphs or computing some of the crucial topological metrics (such as diameter and shortest path) is high, so existing methods do not scale well when the graphs to be classified are large. Another issue of graph classification is that the number of distinct graphs for each class that are available for training a classification model is generally limited. Such scarcity of graph data resources yields models that have much fewer instances than the model parameters, which leads to poor classification performance. In this work, we propose a novel approach for solving graph classification by using two alternative graph representations: the bag of vertices and the bag of partitions. For the first representation, we use representation learning-based node features and for the second, we use traditional metric-based features. Our experiments with 43 real-life graphs from seven different domains show that the bag representation of a graph improves the performance of graph classification significantly. We have shown 4–75% improvement on the vertex-based and 4–36% improvement on partition-based approach over the existing best methods. Besides, our vertex and partition multi-instance methods are on average 75 and 11 times faster in feature construction time than the current best, respectively.
Atomic and Ionized Microstructures in the Diffuse Interstellar Medium

It has been known for half a century that the interstellar medium (ISM) of our Galaxy is structured on scales as small as a few hundred kilometers, more than 10 orders of magnitude smaller than typ...
The Effects of Comprehension-Test Expectancies on Metacomprehension Accuracy.

A set of four experiments assessed the effects of establishing a comprehension-test expectancy (in contrast to a memory-test expectancy) on relative metacomprehension accuracy. Typically readers show poor relative metacomprehension accuracy while learning from text (i.e., they are unable to discriminate topics they have understood well from topics they have understood poorly). In the first experiment, both readers who were given no test expectancy and those who were given a memory-test expectancy made judgments that were more predictive of performance on memory tests than inference tests. However, readers who were given a comprehension-test expectancy made judgments that were more predictive of inference-test performance. This effect was replicated and extended in two additional experiments that showed an effect of comprehension-test expectancy even when no example test items were provided, and when the expectancy was established only after reading. A fourth experiment showed that establishing a comprehension-test expectancy still had an effect on accuracy even when metacomprehension accuracy was already being improved via a self-explanation activity. The results show robust and reliable benefits to metacomprehension accuracy from a comprehension-test expectancy that serves as portable knowledge that learners can apply to monitoring future learning from text. (PsycINFO Database Record (c) 2019 APA, all rights reserved).
Financial Reporting Quality, Investment Horizon, and Institutional Investor Trading Strategies

ABSTRACT This paper provides evidence that financial reporting quality (FRQ) influences the holding costs of trading strategies. While prior research has focused on the benefits of investment strat...
Fast, versatile and quantitative annotation of complex images

We report a generic smartphone app for quantitative annotation of complex images. The app is simple enough to be used by children, and annotation tasks are distributed across app users, contributin...
Temperature explains broad patterns of Ross River virus transmission.

Mosquitoes cannot control their body temperature, so their survival and performance depend on the temperature where they live. As a result, outside temperatures can also affect the spread of diseases transmitted by mosquitoes. This has left scientists wondering how climate change may affect the spread of mosquito-borne diseases. Predicting the effects of climate change on such diseases is tricky, because many interacting factors, including temperatures and rainfall, affect mosquito populations. Also, rising temperatures do not always have a positive effect on mosquitoes – they may help mosquitoes initially, but it can get too warm even for these animals. Climate change could affect the Ross River virus, the most common mosquito-borne disease in Australia. The virus infects 2,000 to 9,000 people each year and can cause long-term joint pain and disability. Currently, the virus spreads year-round in tropical, northern Australia and seasonally in temperate, southern Australia. Large outbreaks have occurred outside of Australia, and scientists are worried it could spread worldwide. Now, Shocket et al. have built a model that predicts how the spread of Ross River virus changes with temperature. Shocket et al. used data from laboratory experiments that measured mosquito and virus performance across a broad range of temperatures. The experiments showed that ~26°C (80°F) is the optimal temperature for mosquitoes to spread the Ross River virus. Temperatures below 17°C (63°F) and above 32°C (89°F) hamper the spread of the virus. These temperature ranges match the current disease patterns in Australia where human cases peak in March. This is two months after the country’s average temperature reaches the optimal level and about how long it takes mosquito populations to grow, infect people, and for symptoms to develop. Because northern Australia is already near the optimal temperature for mosquitos to spread the Ross River virus, any climate warming should decrease transmission there. But warming temperatures could increase the disease’s transmission in the southern part of the country, where most people live. The model Shocket et al. created may help the Australian government and mosquito control agencies better plan for the future.
Retinal Wnt signaling defect in a zebrafish fetal alcohol spectrum disorder model.

Fetal alcohol spectrum disorder caused by prenatal alcohol exposure includes ocular abnormalities (microphthalmia, photoreceptor dysfunction, cataracts). Zebrafish embryos exposed to ethanol from gastrulation through somitogenesis show severe ocular defects, including microphthalmia and photoreceptor differentiation defects. Ethanol-treated zebrafish had an enlarged ciliary marginal zone (CMZ) relative to the retina size and reduced Muller glial cells (MGCs). Ethanol exposure produced immature photoreceptors with increased proliferation, indicating cell cycle exit failure. Signaling mechanisms in the CMZ were affected by embryonic ethanol exposure, including Wnt signaling in the CMZ, Notch signaling and neurod gene expression. Retinoic acid or folic acid co-supplementation with ethanol rescued Wnt signaling and retinal differentiation. Activating Wnt signaling using GSK3 inhibitor (LSN 2105786; Eli Lilly and Co.) restored retinal cell differentiation pathways. Ethanol exposed embryos were treated with Wnt agonist, which rescued Wnt-active cells in the CMZ, Notch-active cells in the retina, proliferation, and photoreceptor terminal differentiation. Our results illustrate the critical role of Wnt signaling in ethanol-induced retinal defects.
Pulse Sequence Resilient Fast Brain Segmentation

Accurate automatic segmentation of brain anatomy from \(T_1\)-weighted (\(T_1\)-w) magnetic resonance images (MRI) has been a computationally intensive bottleneck in neuroimaging pipelines, with state-of-the-art results obtained by unsupervised intensity modeling-based methods and multi-atlas registration and label fusion. With the advent of powerful supervised convolutional neural networks (CNN)-based learning algorithms, it is now possible to produce a high quality brain segmentation within seconds. However, the very supervised nature of these methods makes it difficult to generalize them on data different from what they have been trained on. Modern neuroimaging studies are necessarily multi-center initiatives with a wide variety of acquisition protocols. Despite stringent protocol harmonization practices, it is not possible to standardize the whole gamut of MRI imaging parameters across scanners, field strengths, receive coils etc., that affect image contrast. In this paper we propose a CNN-based segmentation algorithm that, in addition to being highly accurate and fast, is also resilient to variation in the input \(T_1\)-w acquisition. Our approach relies on building approximate forward models of \(T_1\)-w pulse sequences that produce a typical test image. We use the forward models to augment the training data with test data specific training examples. These augmented data can be used to update and/or build a more robust segmentation model that is more attuned to the test data imaging properties. Our method generates highly accurate, state-of-the-art segmentation results (overall Dice overlap = 0.94), within seconds and is consistent across a wide-range of protocols.
The Gut Microbiome in Adult and Pediatric Functional Gastrointestinal Disorders.

The importance of gut microbiota in gastrointestinal (GI) physiology was well described, but our ability to study gut microbial ecosystems in their entirety was limited by culture-based methods prior to the sequencing revolution. The advent of high-throughput sequencing opened new avenues, allowing us to study gut microbial communities as an aggregate, independent of our ability to culture individual microbes. Early studies focused on association of changes in gut microbiota with different disease states, which was necessary to identify a potential role for microbes and generate novel hypotheses. Over the past few years the field has moved beyond associations to better understand the mechanistic implications of the microbiome in the pathophysiology of complex diseases. This movement also has resulted in a shift in our focus toward therapeutic strategies, which rely on better understanding the mediators of gut microbiota–host cross-talk. It is not surprising the gut microbiome has been implicated in the pathogenesis of functional gastrointestinal disorders given its role in modulating physiological processes such as immune development, GI motility and secretion, epithelial barrier integrity, and brain–gut communication. In this review, we focus on the current state of knowledge and future directions in microbiome research as it pertains to functional gastrointestinal disorders. We summarize the factors that help shape the gut microbiome in human beings. We discuss data from animal models and human studies to highlight existing paradigms regarding the mechanisms underlying microbiota-mediated alterations in physiological processes and their relevance in human interventions. While translation of microbiome science is still in its infancy, the outlook is optimistic and we are advancing in the right direction toward precise mechanism-based microbiota therapies.
Urinary-Bladder Management After Total Joint-Replacement Surgery

We conducted a randomized study of 100 patients to examine the efficacy and risks of two methods of urinary-bladder management after total joint-replacement surgery. Patients who had hip or knee replacement were randomly assigned either to Group I, in which indwelling catheters were placed during the operation and removed the next morning, or Group II, in which urinary retention was treated by intermittent catheterization as needed. After the removal of the indwelling catheter, the patients in Group I had a lower incidence of urinary retention than those in Group II (27 vs. 52 percent; P less than 0.01). Bladder distention (volume above 700 ml) was more common in Group II (45 percent as compared with 7 percent in Group I; P less than 0.01) and was associated with an increased need for subsequent long-term catheterization. There was no significant difference between the groups in the rates of urinary tract infection (11 vs. 15 percent). We could not identify patients at high risk for retention or infection on the basis of preoperative urinary symptoms, previous urinary tract surgery, previous urinary tract infection or urinary retention, high-risk medical conditions, sex, type of anesthesia, or age (in the absence of prophylactic treatment). We conclude that the short-term use of an indwelling catheter after extended surgery, such as joint replacement, reduces the incidence of urinary retention and bladder overdistention, without increasing the rate of urinary tract infection.
Collaborating with an Expert Panel to Establish the Content Validity of an Intervention for Preschoolers with Language Impairment.

Expanding on the extant body of research on content validity, this study applied the tenets of content validity research to the development of an expository book reading intervention focused on sci...
I Don’t Know

Political decision makers make choices in a complex and uncertain world, where even the most qualified experts may not know what policies will succeed. Worse, if these experts care about their reputation for competence, they may be averse to admitting what they don’t know. We model the strategic communication of uncertainty, allowing for the salient reality that sometimes the effects of proposed policies are impossible to know. Our model highlights the challenge of getting experts to admit uncertainty, even when it is possible to check predictive success. Moreover, we identify a novel solution: checking features of the question that only good experts will infer—in particular, whether the effect of policies is knowable—can induce uninformed experts do say “I Don’t Know.”
The H3K9 methyltransferase SETDB1 maintains female identity in Drosophila germ cells

The preservation of germ cell sexual identity is essential for gametogenesis. Here we show that H3K9me3-mediated gene silencing is integral to female fate maintenance in Drosophila germ cells. Germ cell specific loss of the H3K9me3 pathway members, the H3K9 methyltransferase SETDB1, WDE, and HP1a, leads to ectopic expression of genes, many of which are normally expressed in testis. SETDB1 controls the accumulation of H3K9me3 over a subset of these genes without spreading into neighboring loci. At phf7, a regulator of male germ cell sexual fate, the H3K9me3 peak falls over the silenced testis-specific transcription start site. Furthermore, H3K9me3 recruitment to phf7 and repression of testis-specific transcription is dependent on the female sex determination gene Sxl. Thus, female identity is secured by an H3K9me3 epigenetic pathway in which Sxl is the upstream female-specific regulator, SETDB1 is the required chromatin writer, and phf7 is one of the critical SETDB1 target genes.
The Contingent Effect of Guardianship on Victimization: An Examination of People With and Without Mental Health Problems:

Mixed effects of guardianship on victimization have been found in the literature. It is possible that these divergent findings have emerged because research has not recognized how the need for guar...
Does It Pay to Be Forthcoming?: Evidence from CSR Disclosure and Equity Market Liquidity

We examine the impact of corporate social responsibility (CSR) disclosure strategies on equity market liquidity. Using data on CSR disclosure from Bloomberg, we find that equity market liquidity improves as firms increase their CSR disclosure transparency. Specifically, firms with more transparent CSR disclosure strategies have narrower spreads and exhibit improvements in common measures of equity market liquidity. Additionally, we document that improvements in equity market liquidity occur contemporaneously with changes in firms' CSR disclosure strategies, suggesting that markets respond to the transparent disclosure of CSR initiatives without necessarily knowing the ultimate efficacy of the initiative itself. We condition our findings on firm transparency and provide evidence that CSR disclosure transparency acts to reduce information asymmetry, thus acting as the mechanism to improve equity market liquidity. Overall, our results suggest that CSR disclosure transparency leads to reductions in asymmetric information, ultimately making financial markets more equitable.
Quantitative proteomic analysis of prostate tissue specimens identifies deregulated protein complexes in primary prostate cancer

Prostate cancer (PCa) is the most frequently diagnosed non-skin cancer and a leading cause of mortality among males in developed countries. However, our understanding of the global changes of protein complexes within PCa tissue specimens remains very limited, although it has been well recognized that protein complexes carry out essentially all major processes in living organisms and that their deregulation drives the pathogenesis and progression of various diseases. By coupling tandem mass tagging-synchronous precursor selection-mass spectrometry/mass spectrometry/mass spectrometry with differential expression and co-regulation analyses, the present study compared the differences between protein complexes in normal prostate, low-grade PCa, and high-grade PCa tissue specimens. Globally, a large downregulated putative protein–protein interaction (PPI) network was detected in both low-grade and high-grade PCa, yet a large upregulated putative PPI network was only detected in high-grade but not low-grade PCa, compared with normal controls. To identify specific protein complexes that are deregulated in PCa, quantified proteins were mapped to protein complexes in CORUM (v3.0), a high-quality collection of 4274 experimentally verified mammalian protein complexes. Differential expression and gene ontology (GO) enrichment analyses suggested that 13 integrin complexes involved in cell adhesion were significantly downregulated in both low- and high-grade PCa compared with normal prostate, and that four Prothymosin alpha (ProTα) complexes were significantly upregulated in high-grade PCa compared with normal prostate. Moreover, differential co-regulation and GO enrichment analyses indicated that the assembly levels of six protein complexes involved in RNA splicing were significantly increased in low-grade PCa, and those of four subcomplexes of mitochondrial complex I were significantly increased in high-grade PCa, compared with normal prostate. In summary, to the best of our knowledge, the study represents the first large-scale and quantitative, albeit indirect, comparison of individual protein complexes in human PCa tissue specimens. It may serve as a useful resource for better understanding the deregulation of protein complexes in primary PCa.
The Fast Cooking and Enhanced Iron Bioavailability Properties of the Manteca Yellow Bean (Phaseolus vulgaris L.).

The common dry bean (Phaseolus vulgaris L.) is a nutrient-dense pulse crop that is produced globally for direct human consumption and is an important source of protein and micronutrients for millions of people across Latin America, the Caribbean and Sub-Saharan Africa. Dry beans require large amounts of heat energy and time to cook, which can deter consumers worldwide from using beans. In regions where consumers rely on expensive fuelwood for food preparation, the yellow bean is often marketed as fast cooking. This study evaluated the cooking time and health benefits of five major market classes within the yellow bean seed type (Amarillo, Canary, Manteca, Mayocoba, Njano) over two field seasons. This study shows how the Manteca yellow bean possesses a fast cooking phenotype, which could serve as genetic resource for introducing fast cooking properties into a new generation of dry beans with cooking times 80%) after boiling. An in vitro digestion/Caco-2 cell culture bioassay revealed a strong negative association between cooking time and iron bioavailability in yellow beans with r values = −0.76 when pre-soaked and −0.64 when unsoaked across the two field seasons. When either pre-soaked or left unsoaked, the highest iron bioavailability scores were measured in the fast cooking Manteca genotypes providing evidence that this yellow market class is worthy of germplasm enhancement through the added benefit of improved iron quality after cooking.
Quantum amplification of mechanical oscillator motion

Detection of the weakest forces in nature is aided by increasingly sensitive measurements of the motion of mechanical oscillators. However, the attainable knowledge of an oscillator's motion is limited by quantum fluctuations that exist even if the oscillator is in its lowest possible energy state. We demonstrate a technique for amplifying coherent displacements of a mechanical oscillator with initial magnitudes well below these zero-point fluctuations. When applying two orthogonal squeezing interactions, one before and one after a small displacement, the displacement is amplified, ideally with no added quantum noise. We implemented this protocol with a trapped-ion mechanical oscillator and determined an increase by a factor of up to 7.3 (±0.3) in sensitivity to small displacements.
The Capacity of Private Computation

We introduce the problem of private computation, comprised of $ {N}$ distributed and non-colluding servers, $ {K}$ independent datasets, and a user who wants to compute a function of the datasets privately, i.e., without revealing which function he wants to compute, to any individual server. This private computation problem is a strict generalization of the private information retrieval (PIR) problem, obtained by expanding the PIR message set (which consists of only independent messages) to also include functions of those messages. The capacity of private computation, $ {C}$ , is defined as the maximum number of bits of the desired function that can be retrieved per bit of total download from all servers. We characterize the capacity of private computation, for $ {N}$ servers and $ {K}$ independent datasets that are replicated at each server, when the functions to be computed are arbitrary linear combinations of the datasets. Surprisingly, the capacity, $ {C}=\left ({1+1/ {N}+\cdots +1/ {N}^{ {K}-1}}\right)^{-1}$ , matches the capacity of PIR with $ {N}$ servers and $ {K}$ messages. Thus, allowing arbitrary linear computations does not reduce the communication rate compared to pure dataset retrieval. The same insight is shown to hold even for arbitrary non-linear computations when the number of datasets $ {K}\rightarrow \infty $ .
Haenszel, William M†

Born 1910; died 1998. Although William M. Haenszel is probably best known as the name to the right of the hyphen on the Mantel–Haenszel test and Mantel–Haenszel odds ratio, he made other equally important contributions throughout a very long and productive career as a biostatistician and epidemiologist. Of particular importance was his leadership in establishing and maintaining the population-based cancer registry known as SEER (for Surveillance Epidemiology and End Results); his comparative studies of cancer occurrence in foreign-born and native-born Japanese Americans; and his use and advocacy of biomarkers and pathological findings in studies of cancer etiology, especially those involving gastric and large bowel cancer. His work from the 1950s to 1970s at the National Cancer Institute was at the cutting edge of chronic disease epidemiology, and greatly enriched that field both substantively and methodologically. Keywords: Mantel–Haenszel test; National Cancer Institute; surveillance epidemiology and end results program; migrant studies
Scattering of electromagnetic waves by cylinder inside uniaxial hyperbolic medium.

We study electromagnetic wave scattering inside a hyperbolic medium by a circular cylinder. The hyperbolic medium’s unique properties result in scattering behaviors that differ greatly from scattering by the same cylinder inside a positive isotropic medium. Incident wave polarization is preserved for all angles of incidence and the scattered waves have the same polarization in the far-field region. TM-polarized plane wave scattering is highly anisotropic. At any given frequency, the dielectric cylinder’s scattering properties can vary from the Rayleigh regime, to the resonant regime, to the evanescent regime, by simply changing the angle of incidence. At a given angle, as a function of frequency, the scattering efficiency exhibits narrow resonant features associated with Fano interference. We also show that a magnetic cylinder’s scattering can be suppressed. All of these effects stem from the hyperbolic medium’s properties, as well as point to the interesting opportunities of tailoring scattering properties by controlling the surrounding medium.
Clustering Financial Return Distributions Using the Fisher Information Metric

Information geometry provides a correspondence between differential geometry and statistics through the Fisher information matrix. In particular, given two models from the same parametric family of distributions, one can define the distance between these models as the length of the geodesic connecting them in a Riemannian manifold whose metric is given by the model’s Fisher information matrix. One limitation that has hindered the adoption of this similarity measure in practical applications is that the Fisher distance is typically difficult to compute in a robust manner. We review such complications and provide a general form for the distance function for one parameter model. We next focus on higher dimensional extreme value models including the generalized Pareto and generalized extreme value distributions that will be used in financial risk applications. Specifically, we first develop a technique to identify the nearest neighbors of a target security in the sense that their best fit model distributions have minimal Fisher distance to the target. Second, we develop a hierarchical clustering technique that utilizes the Fisher distance. Specifically, we compare generalized extreme value distributions fit to block maxima of a set of equity loss distributions and group together securities whose worst single day yearly loss distributions exhibit similarities.
Maternal motives behind elective cesarean sections.

OBJECTIVES The World Health Organization recommends a target cesarean section rate of 10-15%. In recent years, the US has had a nation-wide rate of 30.3% and some developed countries are even higher. Many factors account for this high rate, but our hypothesis is that women who elect cesarean section do so at least in part because of unallayed fear. METHODS Our sample was comprised of American women of childbearing age who have not given birth but may in the near future. We received 368 online survey responses with a 92% completion rate. Responses were categorical and hypotheses tested with non-parametric statistics. RESULTS Those who reported a preference for cesarean section were significantly more likely to be extremely fearful of birth (43.9%) than those who reported a preference for vaginal delivery (20.6%). 73.2% of the cesarean section group state that fear is what influenced their birth preference, 9.8% said their fear had no influence, while in the vaginal birth group 18.9% said fear influenced their birth preference and 53.7% said it did not. CONCLUSIONS In our sample, women likely to elect cesarean sections are motivated at least in part by fear. They report both more extreme levels of fear than the group anticipating non-surgical delivery and they more often say that this fear influences their birth decision. This study offers productive, non-interventional, and inexpensive ways to address women's fears in the hope of reducing unnecessary cesarean sections.
Unicorns, Cheshire cats, and the new dilemmas of entrepreneurial finance

This essay examines the implications of the evolving environment for the formation and financing of new firms in the United States. After the dot.com crash of 2000, there was a regime change in new...