cssi/SciSciGPT-SciSciNet huggingface dataset:
A technique for using parallel pins

Abstract This technique describes the additional use of a paralleling instrument for obtaining parallel pin placement extraorally when this same instrument cannot be used intraorally. This procedure does not require additional patient visits or appreciable extra chair time. Modifications of the technique are possible, and it may be used with the normal, full, tray procedure varying only because of the position or angulation of the teeth in question. In this way, the intraoral paralleling device may provide the means for establishing parallelism for an anterior tooth abutment, and the modified sectional tray will serve as the means for paralleling pins in posterior teeth.
Considerations in choosing a primary endpoint that measures durability of virological suppression in an antiretroviral trial.

Objectives At present, many clinical trials of anti-HIV-1 therapies compare treatments by a primary endpoint that measures the durability of suppression of HIV-1 replication. Several durability endpoints are compared. Design Endpoints are compared by their implicit assumptions regarding surrogacy for clinical outcomes, sample size requirements, and accommodations for inter-patient differences in baseline plasma HIV-1-RNA levels and in initial treatment response. Methods Virological failure is defined by the non-suppression of virus levels at a prespecified follow-up time T(early virological failure), or by relapse. A binary virological failure endpoint is compared with three time-to-virological failure endpoints: time from (i) randomization that assigns early failures a failure time of T weeks; (ii) randomization that extends the early failure time T for slowly responding subjects; and (iii) virological response that assigns non-responders a failure time of 0 weeks. Endpoint differences are illustrated with Agouron's trial 511. Results In comparing high with low-dose nelfinavir (NFV) regimens in Agouron 511, the difference in Kaplan-Meier estimates of the proportion not failing by 24 weeks is 16.7% (P = 0.048), 6.5% (P = 0.29) and 22.9% (P = 0.0030) for endpoints (i), (ii) and (iii), respectively. The results differ because NFV suppresses virus more quickly at the higher dose, and the endpoints weigh this treatment difference differently. This illustrates that careful consideration needs to be given to choosing a primary endpoint that will detect treatment differences of interest. Conclusion A time from randomization endpoint is usually recommended because of its advantages in flexibility and sample size, especially at interim analyses, and for its interpretation for patient management.
Diversification of Ig Superfamily Genes in an Invertebrate

The freshwater snail Biomphalaria glabrata possesses a diverse family of fibrinogen-related proteins (FREPs), hemolymph polypeptides that consist of one or two amino-terminal immunoglobulin superfamily (IgSF) domains and a carboxyl-terminal fibrinogen domain. Here, we show that the IgSF1 domain of the FREP3 subfamily is diversified at the genomic level at higher rates than those recorded for control genes. All sequence variants are derived from a small set of nine source sequences by point mutation and recombinatorial processes. Diverse FREP3 transcripts are also produced. We hypothesize a mechanism present in snails that is capable of diversifying molecules involved in internal defense.
Hypothermia for 24 hours after asphyxic cardiac arrest in piglets provides striatal neuroprotection that is sustained 10 days after rewarming.

The neuroprotective effect of hypothermia instituted after resuscitation from asphyxic cardiac arrest has not been studied in immature brain, particularly in a large animal model with recovery periods greater than 4 d. Moreover, protection from severe hypoxia seen with 3 h of hypothermia was reported to be lost when hypothermic duration was extended to 24 h in unsedated piglets, in contrast to the neuroprotection reported by 72 h of intrauterine head cooling in fetal sheep. Piglets (5-7 postnatal days) were subjected to asphyxic cardiac arrest followed by 24 h of either hypothermia (34 degrees C) or normothermia (38.5-39 degrees C). Comparisons were made with normothermic and hypothermic surgical sham animals without asphyxia. All of these groups were sedated, paralyzed, and mechanically ventilated for the first 24 h to prevent shivering and possible depletion of glucose stores. Hypothermia per se did not cause remarkable structural abnormalities. Ischemic damage was evaluated in putamen at 1 d of recovery without rewarming and at 11 d (10 d +/- SD after rewarming). Ischemic cytopathology affected 60 +/- 12% of neurons in putamen of normothermic animals compared with 9 +/- 6% in hypothermic animals at 1 d of recovery without rewarming. At 11 d of recovery from hypoxia-ischemia, the density of viable neurons (neuron profiles/mm2) in putamen was markedly reduced in normothermic animals (81 +/- 40) compared with hypothermic animals (287 +/- 22), which was the same as in sham normothermic (271 +/- 21), sham hypothermic (288 +/- 46) and naive animals (307 +/- 51). These data demonstrate that 24 h of hypothermia at 34 degrees C with sedation and muscle relaxation after asphyxic cardiac arrest prevents necrotic striatal neuronal cell death in immature brain before rewarming, and that the effect is sustained at 11 d after injury without deleterious side effects.
Microbial Iron Mats at the Mid-Atlantic Ridge and Evidence That Zetaproteobacteria May Be Restricted to Iron-Oxidizing Marine Systems

Chemolithoautotrophic iron-oxidizing bacteria play an essential role in the global iron cycle. Thus far, the majority of marine iron-oxidizing bacteria have been identified as Zetaproteobacteria, a novel class within the phylum Proteobacteria. Marine iron-oxidizing microbial communities have been found associated with volcanically active seamounts, crustal spreading centers, and coastal waters. However, little is known about the presence and diversity of iron-oxidizing communities at hydrothermal systems along the slow crustal spreading center of the Mid-Atlantic Ridge. From October to November 2012, samples were collected from rust-colored mats at three well-known hydrothermal vent systems on the Mid-Atlantic Ridge (Rainbow, Trans-Atlantic Geotraverse, and Snake Pit) using the ROV Jason II. The goal of these efforts was to determine if iron-oxidizing Zetaproteobacteria were present at sites proximal to black smoker vent fields. Small, diffuse flow venting areas with high iron(II) concentrations and rust-colored microbial mats were observed at all three sites proximal to black smoker chimneys. A novel, syringe-based precision sampler was used to collect discrete microbial iron mat samples at the three sites. The presence of Zetaproteobacteria was confirmed using a combination of 16S rRNA pyrosequencing and single-cell sorting, while light micros-copy revealed a variety of iron-oxyhydroxide structures, indicating that active iron-oxidizing communities exist along the Mid-Atlantic Ridge. Sequencing analysis suggests that these iron mats contain cosmopolitan representatives of Zetaproteobacteria, but also exhibit diversity that may be uncommon at other iron-rich marine sites studied to date. A meta-analysis of publically available data encompassing a variety of aquatic habitats indicates that Zetaproteobacteria are rare if an iron source is not readily available. This work adds to the growing understanding of Zetaproteobacteria ecology and suggests that this organism is likely locally restricted to iron-rich marine environments but may exhibit wide-scale geographic distribution, further underscoring the importance of Zetaproteobacteria in global iron cycling.
The Relationship Between Levels of User Experience with a Product and Perceived System Usability

The System Usability Scale (SUS) is a ten-point assessment tool developed as a reliable low-cost subjective usability scale that can be applied to systems in any number of contexts. Research has de...
Unpacking Desensitization, Whiteness, and Violence

As we, two scholars of color, learned about the Boston marathon bombings recently, we simultaneously felt both indifferent and guilty for not feeling much—desensitization. We experienced a similar ...
Languages and Literacies in Translocation Experiences and Perspectives of a Transnational Youth

Transnational youth represent an increasing demographic in societies around the world. This circumstance has amplified the need to understand how youths’ language and literacy repertoires are shaped by transnational life. In response, this article presents a case study of a Mexican adolescent girl who immigrated to the United States and continued to participate in life in Mexico. It examines shifts in her multiple language and literacy practices that she attributed to transnational life and the knowledge she acquired from transnational engagements with languages and literacies. Data include interviews of the young woman, observations of her in a variety of social contexts, and literacy artifacts that she produced. Research on transnational youths’ language and literacy practices and theories of multiliteracies and border crossing facilitate analysis. Findings include that language and multiliteracy practices shift in interconnected ways in response to transnational life and engagements with multiple langu...
Correlation of abnormal Q waves, coronary pathology, and ventricular contractility

Abstract Four hundred and ninety-two patients with coronary artery disease underwent analysis of their electrocardiograms, coronary arteriograms, and ventriculograms. Significant Q-waves were correlated with critical coronary occlusions (≥ 75 per cent obstruction) and ventricular contractility. It was found that Q-waves correlate equally well with ventriculographic abnormalities and critical coronary occlusions. The Q-wave correlation varied from 77 to 87 per cent, depending on the area of myocardium under consideration, except for true posterior myocardial infarction, which correlated 55 per cent with ventriculographic abnormalities and 55 per cent with critical coronary occlusions. Significant Q-waves in Leads II, III, and a V F are better indicators of ventriculographic abnormality than in Leads III and a V F alone, whereas Q-waves in the latter two leads are more definitive than in Lead III alone. Patients who have critical coronary occlusions and normal electrocardiograms have normal ventriculograms in 71 to 78 per cent of the cases, again depending on the area of the myocardium under consideration. Thus, the normal electrocardiogram correlates better with the ventriculogram than with coronary pathology. The abnormal electrocardiogram correlates equally well with both.
Investigation of random lasers with resonant feedback

This paper presents a detailed experimental study of random lasers with resonant feedback. The dependences of the lasing threshold and the number of lasing modes on the transport mean free path, the pump area, and the sample size are measured. An analytical model based on the concept of quasistates is developed to explain the behaviors of random lasers.
Global sensitivity analysis in an ocean general circulation model: a sparse spectral projection approach

Polynomial chaos (PC) expansions are used to propagate parametric uncertainties in ocean global circulation model. The computations focus on short-time, high-resolution simulations of the Gulf of Mexico, using the hybrid coordinate ocean model, with wind stresses corresponding to hurricane Ivan. A sparse quadrature approach is used to determine the PC coefficients which provides a detailed representation of the stochastic model response. The quality of the PC representation is first examined through a systematic refinement of the number of resolution levels. The PC representation of the stochastic model response is then utilized to compute distributions of quantities of interest (QoIs) and to analyze the local and global sensitivity of these QoIs to uncertain parameters. Conclusions are finally drawn regarding limitations of local perturbations and variance-based assessment and concerning potential application of the present methodology to inverse problems and to uncertainty management.
An adaptive optimal-kernel time-frequency representation

Time-frequency representations with fixed windows or kernels figure prominently in many applications, but perform well only for limited classes of signals. Representations with signal-dependent kernels can overcome this limitation. However, while they often perform well, most existing schemes are block-oriented techniques unsuitable for on-line implementation or for tracking signal components with characteristics that change with time. The time-frequency representation developed in the present paper, based on a signal-dependent radially Gaussian kernel that adapts over time, surmounts these difficulties. The method employs a short-time ambiguity function both for kernel optimization and as an intermediate step in computing constant-time slices of the representation. Careful algorithm design provides reasonably efficient computation and allows on-line implementation. Certain enhancements, such as cone-kernel constraints and approximate retention of marginals, are easily incorporated with little additional computation. While somewhat more expensive than fixed kernel representations, this new technique often provides much better performance. Several examples illustrate its behavior on synthetic and real-world signals. >
Variational method for the solution of TPBVP arising in mechanics

This paper is concerned with a new method for solving two point boundary value problems for ordinary differential equations. The method is based on minimizing a cost functional, the solution of which satisfies the required boundary conditions. It searches for the trajectory that satisfies the system of equation, in addition to the required boundary conditions. The method leads to an iterative algorithm which is described in detail. Numerical results for a number of systems appearing in applications is also presented.
Toward an anthropology of women's liberation

Ruby Rohrlich‐Leavitt, ed. Women Cross‐Culturally: Change and Challenge. The Hague and London: Mouton Publishers. A volume in the World Anthropology Series, Sol Tax, general editor. Distributed in North America by Aldine Publishing Co., 1975. xiv + 669 pp. Tables, figures, biographical notes, and indexes. $27.50.
Simulations of spatial DSA morphology, DSA-aware assist features and block copolymer-homopolymer blends

Further enhancements to Monte Carlo and Self-Consistent Field Theory Directed Self-Assembly (DSA) simulation capabilities implemented in GLOBALFOUNDRIES are presented and discussed, along with the results of their applications. We present the simulation studies of DSA in graphoepitaxy confinement wells, where the DSA process parameters are varied in order to determine the optimal set of parameters resulting in a robust and etch transferrable phase morphology. A novel concept of DSA-aware assist features for the optical lithography process is presented and demonstrated in simulations. The results of the DSA simulations and studies for the DSA process using a blend of homopolymers and diblock copolymers are also presented and compared with the simulated diblock copolymer systems.
Abstract LB-268: Tumor classification and prediction using the WG-DASL HT Assay in archived sectioned FFPE (AS-FFPE) material

Proceedings: AACR 102nd Annual Meeting 2011‐‐ Apr 2‐6, 2011; Orlando, FL Formalin-fixed archival tissues represent an invaluable resource for cancer research, since they are widely available and afford correlations of historical clinical data with gene expression signatures thereby facilitating better disease classification and prediction. While FFPE tissue is commonly available in block form, it is also standard practice to archive sectioned slices (AS-FFPE), often at room temperature, which further degrades genetic material due to oxidation. Because of these limitations, gene expression studies using FFPE material are usually performed on material derived from freshly cut blocks and not AS-FFPE samples. Previous mRNA data generated on freshly cut FFPE blocks for two independent liver cancer sample sets yielded gene expression signatures which classified hepatocellular carcinoma (HCC) samples into three subclasses (Cancer Res 2009, 69: 7385) and cirrhotic liver (CL) samples into two (good and poor survival) groups (N Engl J Med 2008, 359:1995). Here, using the WG-DASL HT assay (29K probes), we report on our efforts to use RNA derived from 5-year old AS-FFPE samples that were obtained from a subset of the previously assayed liver cancer sample sets, to generate clinically informative gene expression profiles. With a passing quality control filter of >80% probes detected (p < 0.01) we were able to obtain good quality data for 64/83 (77%) and 37/48 (77%) of the HCC and CL samples, respectively. On average, for the two sample sets, the sample reproducibility across all 29K probe intensities was R2 ∼ 0.85. We next performed prediction analysis using a nearest template prediction method and compared the results with that originally predicted for each of the two sample set. With a confidence threshold of p < 0.05, 38/64 (59%) of the passing HCC samples yielded a prediction with an accuracy of 95% and an error rate of 5%. At the same confidence threshold (p < 0.05), 13/37 (35%) of the passing LC samples yielded a prediction with an accuracy of 69% and an error rate of 31%. Together our results suggest that, despite degradative events such as oxidation and hydrolysis that further fragment archived FFPE sections, gene expression signatures derived from AS-FFPE samples can accurately classify disease states and provide clinically relevant prognoses. Citation Format: {Authors}. {Abstract title} [abstract]. In: Proceedings of the 102nd Annual Meeting of the American Association for Cancer Research; 2011 Apr 2-6; Orlando, FL. Philadelphia (PA): AACR; Cancer Res 2011;71(8 Suppl):Abstract nr LB-268. doi:10.1158/1538-7445.AM2011-LB-268
Design Considerations for Collaborative Visual Analytics

Information visualization leverages the human visual system to support the process of sensemaking, in which information is collected, organized, and analyzed to generate knowledge and inform action. Though most research to date assumes a single-user focus on perceptual and cognitive processes, in practice, sensemaking is often a social process involving parallelization of effort, discussion, and consensus building. This suggests that to fully support sensemaking, interactive visualization should also support social interaction. However, the most appropriate collaboration mechanisms for supporting this interaction are not immediately clear. In this article, we present design considerations for asynchronous collaboration in visual analysis environments, highlighting issues of work parallelization, communication, and social organization. These considerations provide a guide for the design and evaluation of collaborative visualization systems.
Gene expression profile in pelvic organ prolapse

It was hypothesized that the processes contributing to pelvic organ prolapse (POP) may be identified by transcriptional profiling of pelvic connective tissue in conjunction with light microscopy. In order to test this, we performed a frequency-matched case-control study of women undergoing hysterectomy for POP and controls. Total RNA, extracted from uterosacral and round ligament samples used to generate labeled cRNA, was hybridized to microarrays and analyzed for the expression of 32 878 genes. Significance Analysis of Microarrays (Stanford University, CA, USA) identified differentially expressed genes used for ontoanalysis. Quantitative PCR (qPCR) confirmed results. Light microscopy confirmed the tissue type and assessed inflammatory infiltration. The analysis of 34 arrays revealed 249 differentially expressed genes with fold changes (FC) larger than 1.5 and false discovery rates < or =5.2%. Immunity and defense was the most significant biological process differentially expressed in POP. qPCR confirmed the elevated steady-state mRNA levels for four genes: interleukin-6 (FC 9.8), thrombospondin 1 (FC 3.5) and prostaglandin-endoperoxide synthase 2 (FC 2.4) and activating transcription factor 3 (FC 2.6). Light microscopy showed all the samples were composed of fibromuscular connective tissue with no inflammatory infiltrates. In conclusion, genes enriched for 'immunity and defense' contribute to POP independent of inflammatory infiltrates.
Ambrosiella roeperi sp. nov. is the mycangial symbiont of the granulate ambrosia beetle, Xylosandrus crassiusculus

Isolations from the granulate ambrosia beetle, Xylosandrus crassiusculus (Coleoptera: Curculionidae: Scolytinae: Xyleborini), collected in Georgia, South Carolina, Missouri and Ohio, yielded an undescribed species of Ambrosiella in thousands of colony-forming units (CFU) per individual female. Partial sequences of ITS and 28S rDNA regions distinguished this species from other Ambrosiella spp., which are asexual symbionts of ambrosia beetles and closely related to Ceratocystis spp. Ambrosiella roeperi sp. nov. produces sporodochia of branching conidiophores with disarticulating swollen cells, and the branches are terminated by thick-walled aleurioconidia, similar to the conidiophores and aleurioconidia of A. xylebori, which is the mycangial symbiont of a related ambrosia beetle, X. compactus. Microscopic examinations found homogeneous masses of arthrospore-like cells growing in the mycangium of X. crassiusculus, without evidence of other microbial growth. Using fungal-specific primers, only the ITS rDNA region of A. roeperi was amplified and sequenced from DNA extractions of mycangial contents, suggesting that it is the primary or only mycangial symbiont of this beetle in USA.
PROGRESSIVE SUPRANUCLEAR PALSY

Richardson observed an unusual clinical syndrome in the 1950s, which he later designated progressive supranuclear palsy (PSP). Over the past 25 years, although knowledge of this disorder has gradually improved, its cause is still unknown, pathogenesis is unclear, and there is still no definitive treatment for this disorder. This article reviews the epidemiology, clinical features, diagnostic criteria, neuropathology, neuroimaging, and treatment of PSP.
Patterns of macroinvertebrate production, trophic structure, and energy flow along a tallgrass prairie stream continuum

We estimated benthic organic matter standing stocks, macroinvertebrate production, food-web structure, and stream metabolism along a longitudinal continuum of Kings Creek at Konza Prairie Biological Station in Kansas. Benthic macroinvertebrates were sampled for 1 yr from three stream reaches (grass, shrub, gallery forest). Total habitat-weighted production ranged from 9.1 g to 31.9 g ash-free dry weight m22 yr21 with the grass headwaters accounting for the highest production. Functional group contributions to production were similar along the continuum, with collector–gatherers (40–56% of total) and predators (23–38%) dominating all reaches. Detrital pathways appeared to account for most energy flow in all reaches, and all reaches were net heterotrophic on all dates when metabolism was measured, except for the grass headwater reach in spring. Predators were wellrepresented and consumed 65–107% of total macroinvertebrate production, whereas scrapers (11–15%), shredders (2–4%), and filterers (, 1%) consumed relatively small percentages of available resources. Dominance of predators suggested top-down controls are important in this system. However, changes in energy flow through other groups reflected longitudinal variation in resource availability. This prairie stream continuum conforms to some predictions of conceptual stream continua models, but biotic interactions, which are often not considered, may override some predicted responses to changes in the physical template.
Sudden onset of a widespread asymptomatic rash

From D M D D Fund Dr B 3M D C D Bu La A 75-year-oldman presented with a 2-week history of a nonpruritic, painless rash over the lateral aspect of his trunk and his proximal extremities. He denied all American College of Rheumatology criteria for lupus. The patient had a history of kidney cancer, chronic renal failure, and hypertension treated with metoprolol beginning 3 weeks before presentation. There were no known drug allergies and no recent travel. Erythematous 1to 3-mm dermal papules were symmetrically distributed on his trunk (Fig 1) and the posterior and medial upper arms. There was no arthritis, hepatosplenomegaly, or lymphadenopathy. A punch biopsy specimen was obtained, and the results of the histopathologic examination can be seen in Fig 2.
Precipitated Withdrawal From Nicotine Reduces Reinforcing Effects of a Visual Stimulus for Rats

Introduction Research has identified at least two positive reinforcement-related effects of nicotine: (a) primary reinforcement and (b) enhancement of reinforcement from concurrently available stimuli. Prior examples of the reinforcement-enhancing effects with rats showed that repeated, intermittent nicotine exposure increased responding for non-nicotine reinforcers, and this effect remained robust over several weeks. However, the effects of continuous nicotine exposure on responding for a non-nicotine reinforcer are unknown, as are the effects of abruptly withdrawing continuous nicotine on behavior maintained by the same reinforcer. Methods Lever pressing for a visual reinforcer under a fixed ratio schedule was assessed while rats were maintained on a chronic, continuous infusion of nicotine (3.16 mg/kg/day; osmotic minipump). The effects of precipitated withdrawal on responding, following 16 days of continuous nicotine exposure, were assessed by pre-session subcutaneous injections of mecamylamine (1.0 mg/kg). Results Continuous nicotine initially increased active responding for the visual reinforcer; however, continued exposure resulted in an attenuation of this effect. Precipitated withdrawal from nicotine resulted in a significant decline in active responding. Conclusions The initial increase in responding for the visual reinforcer with chronic nicotine exposure is consistent with prior research showing that intermittent exposure to nicotine acts as a reinforcement enhancer. However, the attenuation of this enhancement following prolonged nicotine exposure is in contrast with the persistent effects previously reported. Finally, the decrease in visual reinforcers below control levels (nicotine-naive animals) following nicotine withdrawal highlights a potential for affective withdrawal, which may serve as a motive for continued nicotine use.
Endoplasmic Reticulum Stress Activates Cleavage of CREBH to Induce a Systemic Inflammatory Response

Regulated intramembrane proteolysis (RIP) of endoplasmic reticulum (ER) membrane-anchored transcription factors is known to maintain sterol homeostasis and to mediate the unfolded protein response (UPR). Here, we identified CREBH as a RIP-regulated liver-specific transcription factor that is cleaved upon ER stress and required to activate expression of acute phase response (APR) genes. Proinflammatory cytokines increase expression of ER membrane-anchored CREBH. In response to ER stress, CREBH is cleaved by site-1 and site-2 proteases to liberate an amino-terminal fragment that transits to the nucleus to activate transcription of the genes encoding serum amyloid P-component (SAP) and C-reactive protein (CRP). Proinflammatory cytokines and lipopolysaccharide activate the UPR and induce cleavage of CREBH in the liver in vivo. Together, our studies delineate a molecular mechanism for activation of an ER-localized transcription factor, CREBH, and reveal an unprecedented link by which ER stress initiates an acute inflammatory response.
Hallux, Sesamoid, and First Metatarsal Injuries

Hallux, sesamoid, and first metatarsal injuries are common foot injuries and have implications in the biomechanical functionality of the first ray and foot. They are essential for propulsion in normal gait. As part of the first ray, it is an important contributor to normal locomotion. Any structure disruption or injury can create angular changes or arthritis, which can have biomechanical implications, including pain, disability, compensation, swelling, and reduced range of motion.
Liability for sexual harassment in criminal justice agencies

Abstract This article focuses on sexual harassment in criminal justice agencies from a legal perspective. The article briefly describes sexual harassment cases that address agency liability decided by the United States Supreme Court, discussing the standards of liability articulated in Burlington Industries Inc. v. Ellerth (1998), Faragher v. City of Boca Raton (1998), and Meritor Savings Bank v. Vinson (1986). A more precise understanding of when agencies are liable for the actions of their subordinates is developed through an examination of lower federal court decisions. Trends in the law are identified, as case law is categorized according to harassment by supervisors and co-workers. The article concludes by exploring the policy implications flowing from court decisions and by calling for further research on this troubling aspect of the criminal justice workplace.
Assemblages: Functional units formed by cellular phase separation

The partitioning of intracellular space beyond membrane-bound organelles can be achieved with collections of proteins that are multivalent or contain low-complexity, intrinsically disordered regions. These proteins can undergo a physical phase change to form functional granules or other entities within the cytoplasm or nucleoplasm that collectively we term “assemblage.” Intrinsically disordered proteins (IDPs) play an important role in forming a subset of cellular assemblages by promoting phase separation. Recent work points to an involvement of assemblages in disease states, indicating that intrinsic disorder and phase transitions should be considered in the development of therapeutics.
Conditional speculation and its effects on performance and area for high-level synthesis

We introduce a code transformation technique, "conditional speculation", that speculates operations by duplicating them into preceding conditional blocks. This form of speculation belongs to a class of aggressive code motion techniques that enable movement of operations through and beyond conditionals and loops. We show that, when used during scheduling in a high-level synthesis system, this particular code motion has positive effect on latency and controller complexity, e.g., up to 35 % reduction in longest path cycles and the number of states in the finite state machine (FSM) of the controller. However, it is not enough to determine complexity by the number of states in the control FSM. Indeed, the greater resource sharing opportunities afforded by speculation actually increase the total control cost (in terms of multiplexing and steering logic). This also adversely affects the clock period. We examine the effect of the various code motions on the total synthesis cost and propose techniques to reduce costs to make the transformations useful in real-life behavioral design descriptions. Using the MPEG-1 and ADPCM benchmarks, we show total reductions in schedule lengths of up to 50 % while keeping control and area costs down.
Real-Time Implementation of Fault Detection in Wireless Sensor Networks Using Neural Networks

This paper presents the real-time implementation of a neural network-based fault detection for wireless sensor networks (WSNs). The method is implemented on TinyOS operating system. A collection tree network is formed and multi-hoping data is sent to the base station root. Nodes take environmental measurements every N seconds while neighboring nodes overhear the measurement as it is being forwarded to the base station and record it. After nodes complete M and receive/store M measurements from each neighboring node, recurrent neural networks (RNNs) are used to model the sensor node, the node's dynamics, and interconnections with neighboring nodes. The physical measurement is compared against the predicted value and a given threshold of error to determine sensor fault. By simply overhearing network traffic, this implementation uses no extra bandwidth or radio broadcast power. The only cost of the approach is battery power required to power the receiver to overhear packets and MCU processor time to train the RNN.
Oral Ethanol-Reinforced Responding in Rhesus Monkeys: Effects of Opioid Antagonists Selective for the Μ-,Κ-, or Δ-Receptor

To determine the mechanism by which naltrexone (NTX) reduces oral ethanol-reinforced responding, opioid antagonists that show p-, K-, or &selectivity were evaluated. Rhesus monkeys (n = 6) were given opportunities to respond and receive ethanol (1'%0 or 2%) or water during daily 3-hr drinking sessions. Before some drinking sessions, the monkeys received intramuscular injections of saline or the following drugs: the p-selective irreversible antagonist clocinnamox (CCAM), the K-selective long-lasting antagonist nor-binaltorphimine (nor-BNI), or the &selective antagonist naltrindole. Also, NTX was administered along with either CCAM or nor-BNI. When given alone, CCAM (0.1 mg/kg) had no effect on ethanol-reinforced responding. When NTX (0.32 mg/kg) was given with CCAM, responding maintained by ethanol was decreased. Nor-BNI (3 mg/kg) reduced ethanol-reinforced responding only on the day of injection. On subsequent days, when other studies report continued K-antagonism, responding maintained by ethanol returned to control levels. Also, NTX (0.32 mg/kg), administered in the presence of nor-BNI, was still able to reduce ethanol-reinforced responding. Naltrindole failed to alter responding maintained by ethanol. Because selective antagonism at the p-, K-, or &receptor did not reduce ethanol-reinforced
Work, Family, and Well-Being at Midlife: A Person-Centered Approach

This study addressed work and family enhancement and conflict among adults at midlife (N = 125). The study included personal well-being measured 25 years earlier. Participants were classified into groups on the basis of latent class analysis. Qualitative analyses of narratives within groups enhanced understanding of the experiences of those in the groups. The first of the three groups identified by latent class analysis consisted of a fairly large number of women who seemed to have achieved balance in roles and enjoyed marital and job satisfaction. The second group, almost exclusively male, was characterized by a low degree of work and family enhancement. In the small third group, a profound lack of marital satisfaction coupled with high work and family conflict and low enhancement identified men and women with seemingly enduring low levels of well-being. Narratives largely validated the quantitative analysis but also provided additional avenues for further research.
Design and Implementation of NIMS3D, a 3-D Cabled Robot for Actuated Sensing Applications

We present NIMS3D, a novel 3-D cabled robot for actuated sensing applications. We provide a brief overview of the main hardware components. Next, we describe installation procedures, including novel calibration methods, that enable rapid in-field deployability for nonexpert end users, and provide simulations and experimental results to highlight their effectiveness. Kinematic and dynamic analysis of the system are provided, followed by a description of control methods. We provide experimental results that illustrate tracking of linear and nonlinear paths by NIMS3D. Thereafter, we briefly present an example of an actuated sensing task performed by the system. Finally, we describe methods of improving energy efficiency by leveraging nonlinear trajectories and energy-optimal tension distributions. Experimental and simulated results show that energy efficiency can be improved significantly by using optimized parabolic trajectories. Furthermore, we provide simulation results that demonstrate improved efficiency enabled by optimal, least norm tension distributions.
A Randomized, Controlled Trial of In-Home Drinking Water Intervention to Reduce Gastrointestinal Illness

Trials have provided conflicting estimates of the risk of gastrointestinal illness attributable to tap water. To estimate this risk in an Iowa community with a well-run water utility with microbiologically challenged source water, the authors of this 2000–2002 study randomly assigned blinded volunteers to use externally identical devices (active device: 227 households with 646 persons; sham device: 229 households with 650 persons) for 6 months (cycle A). Each group then switched to the opposite device for 6 months (cycle B). The active device contained a 1-µm absolute ceramic filter and used ultraviolet light. Episodes of “highly credible gastrointestinal illness,” a published measure of diarrhea, nausea, vomiting, and abdominal cramps, were recorded. Water usage was recorded with personal diaries and an electronic totalizer. The numbers of episodes in cycle A among the active and sham device groups were 707 and 672, respectively; in cycle B, the numbers of episodes were 516 and 476, respectively. In a log-linear generalized estimating equations model using intention-to-treat analysis, the relative rate of highly credible gastrointestinal illness (sham vs. active) for the entire trial was 0.98 (95% confidence interval: 0.86, 1.10). No reduction in gastrointestinal illness was detected after in-home use of a device designed to be highly effective in removing microorganisms from water. drinking; epidemiologic studies; gastrointestinal diseases; intervention studies; randomized controlled trials; water; water supply
An Informatics-Based Approach to Object Tracking for Distributed Live Video Computing

Omnipresent camera networks have been a popular research topic in recent years. Example applications include surveillance and monitoring of inaccessible areas such as train tunnels and bridges. Though a large body of existing work focuses on image and video processing techniques, very few address the usability of such systems or the implications of real-time video dissemination. In this paper, we present our work on extending the LVDBMS prototype with a multifaceted object model to better characterize objects in live video streams. This forms the basis for a cross camera tracking framework based on the informatics-based approach which permits objects to be tracked from one video stream to another. Queries may be defined that monitor the streams in real time for complex events. Such a new database management environment provides a general-purpose platform for distributed live video computing.
Urban Environmental Governance, Citizenship and Human Rights in Durban

In the post-apartheid era, the eThekwini (Durban) municipal government has continuously invoked its commitment to the protection of the environment. Such commitment is evident in its programs such as the Municipal Climate Protection Programme and its sustainable development framework. Drawing on case studies from the city of Durban, this paper explores the role of the municipal government in addressing environmental concerns in the post-apartheid period. The paper's objective is to contribute to ongoing scholarly debates focusing on the intersecting themes of urban governance and citizenship.
Faceted Gold Nanorods: Nanocuboids, Convex Nanocuboids, and Concave Nanocuboids.

Au nanorods are optically tunable anisotropic nanoparticles with built-in catalytic activities. The state-of-the-art seed-mediated nanorod synthesis offers excellent control over the aspect ratios of cylindrical Au nanorods, which enables fine-tuning of plasmon resonances over a broad spectral range. However, facet control of Au nanorods with atomic-level precision remains significantly more challenging. The coexistence of various types of low-index and high-index facets on the highly curved nanorod surfaces makes it extremely challenging to quantitatively elucidate the atomic-level structure–property relationships that underpin the catalytic competence of Au nanorods. Here we demonstrate that cylindrical Au nanorods undergo controlled facet evolution during their overgrowth in the presence of Cu2+ and cationic surfactants, resulting in the formation of anisotropic nanostructures enclosed by well-defined facets, such as low-index faceting nanocuboids and high-index faceting convex nanocuboids and concave ...
GEOCHEMICAL STUDY OF OIL AND GAS RESERVOIR FORMATION OF HONGCHE AREA

The oil and gas reservoir types are very various in Hongthe faults of northwestern part of Zhungaer basin,including heavy oil,light oil and dry gas. The heavy oil is distributed at the handing wall, light oil and gas reservoir at the footwall. Reservoirs rang from Carbonniferous to Cretaceous. Oil and gas is sourced from Fengcheng formation and Wuerhe formation of Changji sag based on oil light hydrocarbon and natural gas carbon istope , oil and gas distribution character at different stage and the character of the secondary change are studied. Reservoir formation model is estalished, and favourable exploration area is also determined.
Appication of Suggestopedia in College English Teaching

Based on the analysis of Suggestopedia origin and its theoretical principles,the author analyzes its advantages,and applies this method to college English teaching,at the same time puts forward some principles in the application.
Investigation of torpedo long-range homing performance by using flank array sonar

The capability of long-range homing forms a key problem in torpedo engineering.In this paper,the detection range and bearing accuracy of active signals by using torpedo flank array sonar under atrocious propagation conditions in shallow water have been investigated for the long-range homing performance of torpedo.The numerical results show that the surface ship can be easily detected by torpedo flank array sonar at long-range distance by interception of the transmitted active pulse signals,and the bearing accuracy can also meet the need for torpedo self-guidance.
Determination of formaldehyde in shrimp by HPLC

Objective:To develop a method for determination of formaldehyde in shrimp by HPLC chromatography with UV detector.Methods:The formaldehyde in 5 gram pounding sample was extracted by water and derivatized with 2,4 dinitrophenylhydrazine,then detected by UV detector with the wavelegth at 365 nm.Then it was analyzed by external calibration method.Results:The recoveries were between 94.4%~99.9%,the lowest detection limit 0.20 mg/kg and relative standard deviation below 2%.Conclusion:The method is simple and convenient with good separation for analysis of formaldehyde in shrimp.
SCREAM: sketch resource allocation for software-defined measurement

Software-defined networks can enable a variety of concurrent, dynamically instantiated, measurement tasks, that provide fine-grain visibility into network traffic. Recently, there have been many proposals for using sketches for network measurement. However, sketches in hardware switches use constrained resources such as SRAM memory, and the accuracy of measurement tasks is a function of the resources devoted to them on each switch. This paper presents SCREAM, a system for allocating resources to sketch-based measurement tasks that ensures a user-specified minimum accuracy. SCREAM estimates the instantaneous accuracy of tasks so as to dynamically adapt the allocated resources for each task. Thus, by finding the right amount of resources for each task on each switch and correctly merging sketches at the controller, SCREAM can multiplex resources among network-wide measurement tasks. Simulations with three measurement tasks (heavy hitter, hierarchical heavy hitter, and super source/destination detection) show that SCREAM can support more measurement tasks with higher accuracy than existing approaches.
Darwin the geologist in southern South America

Charles Darwin was a reputable geologist before he achieved biological fame. Most of his geological research was accomplished in southern South America during the voyage of H.M.S. Beagle (1831–1836). Afterward he published four books and several articles about geology and coral atolls and became active in the Geological Society of London. We have followed Darwin's footsteps during our own researches and have been very impressed with his keen observations and inferences. He made some mistakes, however, such as appealing to iceberg rafting to explain erratic boulders and to inundations of the sea to carve valleys. Darwin prepared an important hand-colored geological map of southern South America, which for unknown reasons he did not publish. The distributions of seven map units are shown. These were described in his books wherein he also documented multiple elevated marine terraces on both coasts of South America. While exploring the Andean Cordillera in central Chile and Argentina, he discovered two fossil...
Stability of Sexual Attractions Across Different Timescales: The Roles of Bisexuality and Gender.

We examined the stability of same-sex and other-sex attractions among 294 heterosexual, lesbian, gay, and bisexual men and women between the ages of 18 and 40 years. Participants used online daily diaries to report the intensity of each day’s strongest same-sex and other-sex attraction, and they also reported on changes they recalled experiencing in their attractions since adolescence. We used multilevel dynamical systems models to examine individual differences in the stability of daily attractions (stability, in these models, denotes the tendency for attractions to “self-correct” toward a person-specific setpoint over time). Women’s attractions showed less day-to-day stability than men’s, consistent with the notion of female sexual fluidity (i.e., heightened erotic sensitivity to situational and contextual influences). Yet, women did not recollect larger post-adolescent changes in sexual attractions than did men, and larger recollected post-adolescent changes did not predict lower day-to-day stability in the sample as a whole. Bisexually attracted individuals recollected larger post-adolescent changes in their attractions, and they showed lower day-to-day stability in attractions to their “less-preferred” gender, compared to individuals with exclusive same-sex or exclusive other-sex attractions. Our results suggest that both gender and bisexuality have independent influences on sexual fluidity, but these influences vary across short versus long timescales, and they also differ for attractions to one’s “more-preferred” versus “less-preferred” gender.
Using Systematic Observations to Understand Conditions that Promote Interracial Experiences in Neighbourhood Parks

We analysed observations from 31 neighbourhood parks, with each park mapped into smaller target areas for study, across five US cities generated using the System for Observing Play and Recreation in the Community (SOPARC). In areas where at least two people were observed, less than one-third (31.6%) were populated with at least one white and one non-white person. Park areas that were supervised, had one or more people engaged in vigorous activity, had at least one male and one female present, and had one or more teens present were significantly more likely to involve interracial groups (p<0.01 for each association). Observations in parks located in interracial neighbourhoods were also more likely to involve interracial groups (p<0.05). Neighbourhood poverty rate had a significant and negative relationship with the presence of interracial groups, particularly in neighbourhoods that are predominantly non-white. Additional research is needed to confirm the impact of these interactions. Urban planning and public health practitioners should consider the health benefits of interracial contact in the design and programming of neighbourhood parks.