cssi/SciSciGPT-SciSciNet huggingface dataset:
Envisioning the Time of Testimony: The Analyst as the Other Witness

This essay interrogates the relation between psychoanalysis, detection and testimony, arguing that psychoanalysis can help us envision the time of testimony as the time of creative repetition – what will be called, following Jacques Lacan, remembrance in the future anterior – only after it critically engages its own relationship to the trial and the model of juridical witnessing to which all witnessing is often assimilated. The essay also shows that such a possibility for memory exceeds the private sphere of psychoanalysis and can fully inhabit the social and aesthetic domain of film.
Cost-effective evaluation of impotence

Abstract Two hundred consecutive men presenting with a chief complaint of impotence have been evaluated with a protocol involving one or two outpatient visits. The initial evaluation for all patients consisted of a history taken in a conventional manner and supplemented by a patient-completed sexual function questionnaire, physical examination, serum testosterone and prolactin, and two-night nocturnal penile tumescence studies. Following the initial evaluation the patients were placed in one of three categories: (1) organic impotence, (2) functional impotence, (3) ambiguous impotence (mixed functional and organic impotence or organic impotence of undetermined etiology). Patients in the latter group underwent additional testing including penile vascular studies, two-hour oral glucose tolerance test, and psychiatric consultation. With this protocol, patients can be efficiently and effectively evaluated as outpatients with costs ranging from $250 to $450.
Centrality, gossip, and diffusion of information in networks

How can we identify the most influential nodes in a network for initiating diffusion? Are people able to easily identify those people in their communities who are best at spreading information, and if so How? Using theory and recent data, we will examine these questions and see how the structure of social networks affects information transmission ranging from gossip to the diffusion of new products. In particular, the concept of diffusion centrality from Banerjee, Chandrasekhar, Duflo, and Jackson (2013) will be considered and shown to nest degree centrality, eigenvector centrality, and other measures of centrality as extreme special cases. Then it will be shown that by tracking gossip within a network, nodes can easily learn to rank the centrality of other nodes without knowing anything about the network itself. Finally, the theoretical predictions will be tested with data. The results are presented in Banerjee, Chandrasekhar, Duflo, and Jackson (2014).
Processes of flats induced by higher dimensional processes

Stationary processes of k-flats in \(\mathbb{E}\)d can be thought of as point processes on the Grassmannian \(\mathcal{L}\)kd of k-dimensional subspaces of \(\mathbb{E}\)d. If such a process is sampled by a (d−k+ j)-dimensional space F, it induces a process of j-flats in F. In this work we will investigate the possibility of determining the original k-process from knowledge of the intensity measures of the induced j-processes. We will see that this is impossible precisely when 1<k<d−1 and j=0,...,2[r/2]−1, where r is the rank of the manifold \(\mathcal{L}\)kd. We will show how the problem is equivalent to the study of the kernel of various integral transforms, these will then be investigated using harmonic analysis on Grassmannian manifolds.
Humectant release from membrane materials

Abstract We report the results of membrane filtration studies designed to measure the removal of humectant preservatives (expressed as total organic carbon) from new membrane samples. Membranes with different characteristic properties, that is, relative molecular mass cutoff and material chemistry, were filtered with deionized water under constant flux and feed water temperature (in either dead-end or cross-flow devices) to determine the area-normalized filtrate volume required to remove all of the measurable organic carbon. For specific cases, the effects of changing flux and feed water temperature are also reported. Release of humectants depends on the nominal relative molecular mass cutoff and the thickness (including support) of the membrane—complete removal is not simply predicted by a soaking time or measured volume of deionized water filtered through the membrane without regard to the flux. This report provides general guidance and a suggested measurement technique for monitoring the removal of membrane preservatives prior to membrane application studies.
A note on analytic spread

We give a new characterization of the analytic spread of ideals in local rings with infinite residue fields. This new characterization answers a question of Huneke and can simplify Huneke's constructions in [1]
Detection of symmetrical objects using the bistatic multipolarimetric reverse-time migration imaging technique

An ideal sensor for mine detection would not only provide sufficient information to detect subsurface objects, but also to identify the object as a mine or a clutter object. Without this ability, the sensor will suffer from an unacceptably high false alarm rate in a high clutter environment. This capability to discriminate can be accomplished by taking into account the fact that most landmines have vertical planes of symmetry that are not found in other natural objects. There are specific scattering responses from a symmetric object that are independent of size, shape, dielectric or target depth. A target identification technique has been developed to exploit this feature using sets of bistatic and multipolarimetric data collected by GPR. The data sets are grouped into various subarrays and synthesized into a subsurface image using a 3D FDTD-based Multipolarimetric Reverse-Time Migration imaging techniques. These subarrays will be combined to from multiple mirrored elements to detect the presence of vertical symmetry. A measurement method was developed to represent numerically the level of symmetry associated with the subsurface object. These sets of numerical values, together with the total scattering response, can be used to from a false color image that locates and identifies the presence of a mine. Simulated results demonstrate the potential of this method.© (2000) COPYRIGHT SPIE--The International Society for Optical Engineering. Downloading of the abstract is permitted for personal use only.
HELPER: an interactive extensible debugging system

HELPER is a symbol oriented debugging system used for programs which have been compiled previously. It is easily extensible employing an incremental compiler to process commands given in a natural language. Programs are executed by simulation permitting a number of analysis actions to take place on each instruction. Debugging is both dynamic and static. Many program errors are caught before execution and a back up feature is provided to check code in the neighborhood of an error. Free access to more machine oriented debugging tools is possible and a complete record of each computer session is kept.
3D (13)C-(13)C-(13)C correlation NMR for de novo distance determination of solid proteins and application to a human alpha-defensin.

Abstract The de novo structure of an antimicrobial protein, human α-defensin 1 (HNP-1), is determined by combining a 3D 13 C– 13 C– 13 C (CCC) magic-angle spinning (MAS) correlation experiment with standard resonance assignment experiments. Using a short spin diffusion mixing time to assign intra-residue cross peaks and a long mixing time to detect inter-residue correlation peaks, we show that the 3D CCC experiment not only reduces the ambiguity of resonance assignment, but more importantly yields two orders of magnitude more long-range distances without recourse to existing crystal structures. Most of these distance constraints could not be obtained in a de novo fashion from 2D correlation spectra due to significant resonance overlap. Combining the distance constraints from the 3D CCC experiment and the chemical-shift-derived torsion angles, we obtained a de novo high-resolution NMR structure of HNP-1, with a heavy-atom RMSD of 3.4 A from the crystal structure of the analogous HNP-3. The average energy of the minimum-energy ensemble is less than of 40 kcal/mol. Thus, the 3D CCC experiment provides a reliable means of restraining the three-dimensional structure of insoluble proteins with unknown conformations.
Pyrazole complexes as anion receptors: effects of changing the metal, the pyrazole substitution pattern, and the number of pyrazole ligands.

Compound cis,fac-[Mo(η3-allyl)(CO)2(Hdmpz)3]BAr‘4 (1) (Hdmpz = 3,5-dimethylpyrazole, Ar‘ = 3,5-bis(trifluoromethyl)phenyl) undergoes rapid substitution of one of the pyrazole ligands by anions, including the low nucleophilic ReO4-, a reaction that afforded [Mo(OReO3)(η3-allyl)(CO)2(Hdmpz)2] (2), structurally characterized by X-ray diffraction. The new compounds fac-[Mn(CO)3(Hdmpz)3]BAr‘4 (4a) and fac-[Mn(CO)3(HtBupz)3]BAr‘4 (4b) (HtBupz = 3(5)-tert-butylpyrazole) also undergo pyrazole substitution with most anions, and the product from the reaction with nitrate was crystallographically characterized. Compounds 4a,b were found to be substitutionally stable toward perrhenate, and the adducts [Mn(CO)3(Hdmpz)3]·[ReO4] (7a) and [Mn(CO)3(HtBupz)3]·[ReO4]·[Bu4N]·[BAr‘4] (7b), crystallographically characterized, display hydrogen bonds between one of the perrhenate oxygens and the N−H groups of two of the pyrazole ligands. The structurally similar adduct [Re(CO)3(Hdmpz)3]·[ReO4] (8) was found to result from the in...
Use of a rodent model to show that varicella-zoster virus ORF61 is dispensable for establishment of latency.

Varicella-zoster virus (VZV) results in a latent infection in humans after primary infection. Latency has also been established in guinea pigs and rats after inoculation with the virus. It was found that infection of cotton rats with the Oka vaccine strain of VZV results in a latent infection. To begin to identify which genes are required for latency, we infected cotton rats with VZV strain Oka that is deleted for ORF61. ORF61 protein transactivates certain VZV promoters and enhances the infectivity of viral DNA in transient transfections. Deletion of ORF61 results in abnormal syncytia and impairs the growth of VZV in vitro. Inoculation of cotton rats with ORF61-deleted Oka virus resulted in latent VZV infection in the nervous system similar to that seen for animals infected with parental virus. Thus, the cotton rat can be used to study the ability of mutants in the Oka vaccine strain of VZV to establish latent infection.
A Statistical Comparison of the Efficacy of Large Lecture Versus Smaller Recitation Sections Upon Achievement in General Psychology

(1951). A Statistical Comparison of the Efficacy of Large Lecture Versus Smaller Recitation Sections Upon Achievement in General Psychology. The Journal of Psychology: Vol. 31, No. 2, pp. 297-300.
Microporous Poly(L-Lactic Acid) Membranes Fabricated by Polyethylene Glycol Solvent-Cast/Particulate Leaching Technique

With the eventual goal of developing a tissue-engineered tear secretory system, we found that primary lacrimal gland acinar cells grown on solid poly(L-lactic acid) (PLLA) supports expressed the best histiotypic morphology. However, to be able to perform vectorial transport functions, epithelia must be supported by a permeable substratum. In the present study, we describe the use of a solvent-cast/particulate leaching technique to fabricate microporous PLLA membranes (mpPLLAm) from PLLA/polyethylene glycol blends. Scanning electron microscopy revealed pores on both the air-cured (∼4 μm) and glass-cured sides (<2 μm) of the mpPLLAm. Diffusion studies were performed with mpPLLAm fabricated from 57.1% PLLA/42.9% polyethylene glycol blends to confirm the presence of channelized pores. The data reveal that glucose, L-tryptophan, and dextran (a high molecular weight glucose polymer) readily permeate mpPLLAm. Diffusion of the immunoglobulin G through the mpPLLAm decreased with time, suggesting the possible adsor...
Knowledge dissemination in operations management: Published perceptions versus academic reality

Abstract The channels for knowledge generation and dissemination in the business disciplines are many: presenting research at conferences, writing books, distributing working papers, offering insights in society newsletters, giving invited talks, publishing studies in academic journals, and many other venues, including even blogs and perhaps Facebook ® . But the most important venue is probably published research in “top-level” academic journals. In the discipline of Operations Management, many studies and lists have been published that attempt to determine which of these journals are supposedly the “top” according to either citation analyses, the opinion of recognized experts, author affiliations, bibliometric studies, and other approaches. These lists may then, in turn, be used in different degrees to evaluate research. However, what really counts is what the academic institutions actually use for guidance in evaluating faculty research. Based on a new source of ranking data from AACSB-accredited schools, we compare published journal-ranking studies against that of academe to determine the degree to which the studies reflect academic “reality”. We present rankings of OM journals based on this new source of data and on an aggregate of the stream of published studies, and evaluate their consistency.
An implicit finite-difference algorithm for hyperbolic systems in conservation-law form

An implicit finite-difference scheme is developed for the efficient numerical solution of nonlinear hyperbolic systems in conservation-law form. The algorithm is second-order time-accurate, noniterative, and in a spatially factored form. Second- or fourth-order central and second-order one-sided spatial differencing are accommodated within the solution of a block tridiagonal system of equations. Significant conceptual and computational simplifications are made for systems whose flux vectors are homogeneous functions (of degree one), e.g., the Eulerian gasdynamic equations. Conservative hybrid schemes, which switch from central to one-sided spatial differencing whenever the local characteristic speeds are of the same sign, are constructed to improve the resolution of weak solutions. Numerical solutions are presented for a nonlinear scalar model equation and the two-dimensional Eulerian gasdynamic equations.
Hyponatremia in older adults presenting to the emergency department.

Abstract Hyponatremia is a common disorder seen in the emergency department and is more prevalent in older adults than in other adult populations (Miller, 2009). Though often discovered by accident, through routine bloodwork, even mild hyponatremia has been shown to have potentially dangerous consequences for older adults, increasing their risks for falls, altered mental status, osteoporosis and fractures, and gastrointestinal disturbances (Soiza and Talbot, 2011). Optimal management of older adults with hyponatremia in the ED involves not only treatment of serum sodium levels and the immediate consequence of the disorder, but exploration and reversal of the causes of the hyponatremia to avoid recurrence. This case study illustrates the clinical presentation, complications and management of hyponatremia in the setting of the emergency department.
Volumes for Eigensections

It is well known that the size, e.g. Hausdorff measure, of a nodal set of an eigenfunction tends to increase with the eigenvalue. However, because of the highly oscillatory behavior, it is unclear what happens to the volume of the sets where the eigenfunctions are small. In this paper, we show that this volume is bounded uniformly from below for eigenfunctions and, at least on average, for eigenforms (a simple example shows that it need not be true uniformly for eigenforms). The results here answer a question of S. T. Yau.
Olfactory basis of kin recognition in toad tadpoles

1. Larvae of the American toad (Bufo americanus) preferentially associate with their siblings in laboratory tests, suggesting that they can recognize kin. The sensory basis of their kin recognition abilities was investigated by measuring the responses of individuals in a Y-maze to waterborne cues emanating from their siblings and from nonsiblings. 2. When simultaneously presented with water flowing from two containers, each holding members of a different sibling group, test subjects spent significantly more time oriented toward their siblings than toward non-siblings. Similar results were obtained when the stimulus water was first passed through intermediary reservoirs. Hence, kinship cues are unlikely to be acoustic or vibratory stimuli perceived by the auditory or lateral line systems. 3. Tadpoles whose external nares were blocked with a gelatinous paste did not behaviorally discriminate between water flowing from siblings and that flowing from non-siblings. Retested after their nares were unplugged, these individuals oriented significantly toward their siblings, as did shamtreated test individuals. 4. Stimulus water conditioned by sibling groups and then stored for 24–30 h failed to elicit a discrimination response, indicating that kinship cues released by tadpoles lose their effectiveness during this period. Signals with rapid fade-out times would probably be more efficient under natural conditions than those that persisted after individuals had moved. 5. Test subjects simultaneously presented with water flowing from siblings and blank (dechlorinated tap) water showed no tendencies to discriminate between these stimuli. When individuals were exposed both to water from non-siblings and to blank water, however, they oriented significantly toward the blank water. Kin association may thus result in part from negative klinokinetic responses induced by contact with factors released by nonkin. 6. Chemical cues released by tadpoles appear sufficient to communicate their kinship identity. These cues are probably perceived and processed by the main olfactory system. Kin recognition mechanisms may be further elucidated by chemical and neurophysiological analyses.
Polarization-transforming antenna feed horns

A set of polarization-transforming antenna feed horns has been developed for an X -band radar antenna. Use of the proper feed horn permits transmission of horizontal, vertical, 45\deg linear, 135\deg linear, right circular or left circular polarization, and reception of both the parallel- (same sense as transmitted) and orthogonal-polarized return.
Supercritical behaviour of the mixed state of Nb-Ti in high magnetic fields

Abstract Measurements of the magnetic torque hysteresis in the mixed state of Nb-Ti are reported. The magnitude of the zero-field-cooled hysteresis in high magnetic fields persists in fixed fields to temperatures near the irreversibility line without significant decay. The data suggest that a supercritical state of the flux-line system is sustained in high magnetic fields. The compounds UBe13 and YBa2Cu3O7-δ show the same behaviour.
The relationship between simple and double opponent cells

Little is known about the formation of double opponent cells (DOCs) from geniculate afferents. Three LGN cell types have been considered as DOC precursors. No simple wiring scheme based on these cell types is consistent with the available evidence. The color and luminance multiplexed signal of P beta ganglion cells (Type I receptive fields) contains the information necessary to construct DOCs, provided that filtering operations can separate the two signals. Electrophysiological and anatomical evidence is consistent with Type I cells being filtered prior to the formation of DOCs. Cortical Type II and Type III cells can also be created by filtering.
Regionalization of present-day precipitation in the greater monsoon region of Asia

AbstractThe spatial domain of the Asian monsoon has been defined by the intensity, seasonal concentration, and annual range of precipitation. Monsoon subdomains, such as the Indian monsoon, East Asian monsoon, and western North Pacific monsoon, have also been identified based on seasonal wind reversals as well as the timing and source of monsoon moisture. However, precipitation across the Asian monsoon region is heterogeneous and spatially complex and may have influences farther north than commonly assumed, particularly if scientists consider records of past variability spanning the current interglacial period. This paper presents an additional means of identifying the Asian monsoon domain and monsoon subsystems using an empirical orthogonal function (EOF)-based regionalization of gridded precipitation values. Regions of unique precipitation variability for the Asian monsoon region are determined using monthly precipitation anomalies from the Climate Prediction Center Merged Analysis of Precipitation (CMA...
Some problems and models for time-phased transport requirements. Chance constrained programs with normal deviates and linear decision rules

This paper discusses the possibilities of analysis of risk and uncertainty in forward planning in time for implementation of transport requirements by means of “chance-constrained” programming models [1]. The possibilities of using chance-constrained programming models, in place of queuing models, and the solution of such a model for the leasing of tanker fleets. is considered in some detail.
Defect formation in 800-MeV proton-irradiated aluminum

Abstract Transmission electron microscopy was used to investigate the formation of irradiation-induced defects in proton-irradiated high-purity aluminum. The specimens were irradiated by 800-MeV protons to about 0.25 displacements per atom (dpa) in the Los Alamos Meson Physics Facility (LAMPF), producing about 20 appm helium, 130 appm hydrogen, and approximately 70 appm of spallation products. The as-irradiated microstructure mainly consisted of cavities with a mean size of 88 A, number density of 1 × 10 15 cavities/cm 3 , and volume fraction of about 0.05%. The swelling was comparable to that of high-purity aluminum samples neutron-irradiated to the same displacement level. However, the high production rate of gas atoms during the proton irradiation increased the cavity number density by an order of magnitude relative to neutron irradiation, and reduced the cavity size by a factor of about 3. A postirradiation annealing treatment at 250°C resulted in complete disappearance of the small cavities and formation of gas bubbles on grain boundaries.
Cotreatment With Interleukin 4 and Interleukin 10 Modulates Immune Cells and Prevents Hypertension in Pregnant Mice

Background Excessive maternal immune system activation plays a central role in the development of the hypertensive disorder of pregnancy preeclampsia (PE). The immunomodulatory cytokines interleukin 4 (IL-4) and interleukin 10 (IL-10) are dysregulated during PE; therefore we hypothesized that treatment with both recombinant IL-4 and IL-10 during pregnancy could prevent the development of PE in mice. Methods Using our mouse model of PE in which immune system activation is induced by the double-stranded RNA receptor agonist poly I:C, we gave daily injections of IL-4, IL-10, or both on days 13-17 of pregnancy. Mice were then killed on day 18. Results Poly I:C caused a significant increase in systolic blood pressure in pregnant (P-PIC) mice compared with vehicle-treated pregnant (P) mice. All 3 treatments significantly decreased blood pressure in P-PIC mice to P levels, ameliorated the endothelial dysfunction, and decreased placental TLR3 levels in P-PIC mice. However, only IL-4/IL-10 cotreatment prevented the proteinuria and increased incidence of fetal demise in P-PIC mice; IL-4 or IL-10 alone had no effect. Additionally, only IL-4/IL-10 cotreatment prevented the significant increase in CD3(+)/γδ(+) T cells and CD11c(+) dendritic cells and significant decrease in CD11b(+)/CD14(-) suppressor monocytes, as well as completely prevented placental necrosis, in P-PIC mice. Importantly, IL-4/IL-10 cotreatment in P mice had no detrimental effects. Conclusions Taken together, these data demonstrate that exogenous IL-4 and IL-10 administration concurrently during pregnancy can normalize immune cell subsets and prevent PE induced by maternal immune system activation.
Stereoselective additions of phenylmagnesium bromide to N-substituted-2-azabicyclo[2.2.2]octa-5- and 6-ones

The addition of phenylmagnesium bromide to ketones derived from 2-azabieyclo[2.2.2]-octane was shown to proceed in a stereoselective manner to produce only one of two possible phenyl alcohol derivatives. Factors affecting the course of addition and the determination of relative stereochemistry of the resulting phenyl alcohols are discussed.
"Megaconial" mitochondria observed in a case of chronic polymyositis.

Bizarre configurations of muscle mitochondria containing paracrystalline inclusions were demonstrated in a clinically and pathologically typical case of chronic polymyositis with Raynaud's syndrome. The probable mechanism of formation of these abnormal mitochondria was discussed. From the accompanied alterations in the same fibers, i.e. focal assembly of sarcoplasmic reticulum, membranous profiles, miniature mitochondria, and vesicular nuclei with prominent nucleoli, the overall phenomena were interpreted as a process of atypical regeneration. The detail of the subunits of the paracrystalline inclusions was described and considered to be filamentous structures arranged in double helix. Non-specificity of these mitochondrial abnormalities was evident in 19 other reported cases with a wide range of symptoms, signs, clinical diagnosis, age, and sex distribution. The mitochondrial alterationsper se do not, therefore, reflect any specific muscle disease. Observations of myxovirus-like structures in all 3 biopsy specimens in the present case is discussed in conjunction with the concurrent abnormal mitochondria.
The Legendary Commander: the construction of an Albanian master‐narrative in post‐war Kosovo*

. The ongoing, post-war construction of Albanian martyrs, memory and the nation in Kosovo has produced iconic tropes of militant resistance, unity and national independence. This critical interpretive account, based on years of the authors' ethnographic and political engagement with Albanians in post-war Kosovo, focuses on the making of a master narrative that is centred on the ‘sublime sacrifice’ of the insurgent KLA leader Adem Jashari, known as the ‘Legendary Commander’. It also aims to trace voices of discord with this master narrative, testing contestations in terms of the rural–urban, political and gender divides in Kosovo-Albanian society. It concludes that the narrow international view of Albanians as either ‘victims’ or ‘perpetrators’ has contributed to the consolidation of this powerful narrative, its celebration of Albanian agency in militant resistance and the closing of public debate within Albanian society.
The Staphylococcal Scalded-Skin Syndrome: Isolation and Partial Characterization of the Exfoliative Toxin

Sterile, cell-free filtrates of five strains of coagulase-positive phage group II staphylococci that were cultured in vivo produced exfoliation in newborn mice after intraperitoneal, oral, or subcutaneous administration. Filtrates prepared in a similar manner from coagulase-positive staphylococci of other phage groups failed to produce exfoliation. All filtrates contained staphylococcal alpha hemolysin, the activity of which could be neutralized with specific antiserum. The toxin responsible for the exfoliative phenomenon was a macromolecular ampholyte with a molecular weight of the same order as that of alpha hemolysin. Its behavior was similar to that of alpha hemolysis on gel filtration on Sephadex, Pevikon-block electrophoresis, ultrafiltration, and ultracentrifugation. It was partially separated from alpha hemolysin by precipitation with ammonium sulfate. Isoelectric focusing showed that the exfoliative toxin had an isoelectric point of 7.0 and could be completely separated from the more basic alpha hemolysin by this technique. After purification, approximately 0.5 jxg of the powdered toxin was sufficient to cause exfoliation in the newborn mouse. The identification and separation of the staphylococcal exfoliative toxin and the production of a skin lesion with a partially purified preparation establish this toxin as the etiologic agent of the skin changes seen in children with the staphylococcal scalded-skin syndrome.
T- and B-lymphocytes and lymphoblasts in untreated acute lymphocytic leukemia.

This study demonstrates in the peripheral blood and bone marrow of patients with untreated acute lymphocytic leukemia (ALL) the coexistence of two main subpopulations of lymphoid cells: 1) small lymphoid cells which bear the same surface markers as normal lymphocytes; and 2) blasts which in the majority of the patients lack these markers. The proportions of cells bearing different cell-surface markers were studied in 14 children with ALL at time of diagnosis. Thymus-dependent (T) cells were identified by spontaneous formation of rosettes with sheep erythrocytes, and thymus-independent (B) cells by immunofluorescence of surface immunoglobulins. Using these criteria we demonstrated small lymphocytes with T- or B-markers in the peripheral blood or bone marrow of all patients assayed. In contrast, in 10 of 14 children the blasts had no detectable markers. However, in 2 patients more than half of bone marrow blasts had T-cell surface receptors, and in another 2 the proportion of blasts forming rosettes was 2% and 17%. The initial blast cell count in peripheral blood was greater than 105/mm3 in both children with the higher proportion of T-lymphoblasts. An additional initial clininal feature in one of them was the presence of a large anterior mediastinal mass, probably thymus. After successful induction of remission there was an increase in the proportion of normal T-lymphocytes in the bone marrow of 9 children assayed. The results from this study suggest that the presence of T-lymphoblasts, which may be of thymic origin, is correlated with a more advanced disease at time of diagnosis.
Surface-normal electro-aborption MQW modulator-based chip-scale optical interconnects

A MQW/EAM-based chip-scale photonic interconnect concept, that uses efficient CW VCSELs as sources and a lithographically-defined high-density multi-mode waveguide fabric, is analyzed. Projected energy-per-bit, bandwidth density, and packaging tolerances enable scaling with foreseeable CMOS technology.
Solvating gas chromatography using ammonia as mobile phase

Abstract In this study, the use of ammonia as the mobile phase in packed capillary column solvating gas chromatography (SGC) was investigated. Fused-silica capillary columns (0.9 m×250 μm I.D.) packed with 15 μm octadecyl bonded and polydimethylsiloxane encapsulated silica particles (300 A) were evaluated under SGC conditions. Flame ionization detection was used for detection. Anilines, aliphatic (primary, secondary, and tertiary) amines, and aliphatic diamines were separated under SGC conditions. Although ammonia was converted from a liquid to a gas along the column, no significant loss in column efficiency was observed.
Steven: testing the limits of assertive community treatment.

Sometimes assertive outreach is not enough; this case report describes a ten-year effort to engage an often homeless, alcoholic schizophrenic man.
Monte Carlo simulation of the fcc antiferromagnetic Ising model

Monte Carlo methods are employed to measure the internal energy, sublattice magnetization, and spin-spin correlation function of the fcc antiferromagnetic Ising model as a function of temperature. The internal energy of both the ordered and disordered phases is fitted by appropriate series expansions, and the free energy is obtained analytically from the series. The ordering transition is seen to be of first order with a transition temperature of 1.736\ifmmode\pm\else\textpm\fi{}0.001 in units of the nearest-neighbor coupling $J$. These results are compared with earlier approximations of the model, in particular, the low-temperature series expansion and the Kikuchi tetrahedron approximation, and other Monte Carlo results. The spin-spin correlation function was measured in the disordered phase up to eight lattice spacings in the [100] direction. The correlation length at the transition is found to be $\ensuremath{\sim}2.5a$. The behavior of the correlation length is approximately mean-field-like.
The Relationship Between College Students' Self-Reports of Class Participation and Perceived Instructor Impressions

The purpose of this investigation was to identify the extent to which college students' self-reports of their in-class participation are related to their impressions of instructors (i.e., credibility, attractiveness, and homophily). Participants were 223 undergraduate students enrolled in an introductory communication course at a large Mid-Atlantic university. Students' self-reports of their in-class participation were positively correlated with perceived instructor social attractiveness, physical attractiveness, background homophily, and attititude homophily, but not with perceived instructor competence, character, caring, and task attractiveness. Furthermore, class size, perceived instructor social attractiveness, and perceived instructor background homophily emerged as significant predictors of in-class participation.
Comparison of the sedimentation of a diatom spring bloom and of a subsurface chlorophyll maximum

The seasonal pattern of sedimentation was determined over a 8-mo investigation period covering the productive season at a permanent station in the Southern Kattegat (Denmark) in 1990. The phytoplankton succession was characterised by a 4-mo long subsurface maximum associated with the pycnocline which was entirely dominated by the dinoflagellate Gyrodinium aureolum. The bulk sedimentation of organic matter took place during this period and accounted for >60% of the annual particulate organic carbon (POC) and particulate organic nitrogen (PON) sedimentation. The spring bloom period contributed 60% of the sedimentation of intact phytoplankton cells, but only 20% of the POC and PON sedimentation. A minor fraction of the sedimenting matter from the subsurface phytoplankton maximum consisted of intact phytoplankton (<20%), suggesting that the phytoplankton was processed by heterotrophs and that it was mainly products from this activity which contributed to thevertical flux of organic matter. The variation in oxygen concentration below the pycnocline coincided with the pattern of sedimentation with a delay of 3 to 6 wk.
Drug use in an alternative high school.

The drug involvement of students in an alternative high school is reported. Students include those transferred for behavior problems or dropouts returning to complete school. Drug use rates are exceptionally high, with significantly higher lifetime prevalence for nearly every drug. Current use of drugs is also very high, and 70 percent are in the two most serious adolescent drug use types; about a third are polydrug users, currently using at least two drugs with different psychoactive effects, and another third are stimulant users, taking marijuana, uppers, and/or cocaine. Only alcohol and marijuana were started earlier than other students–these students started both in early junior high. These extreme levels of involvement suggest further assessment of alternative schools and, if generalizability is confirmed, focusing of prevention and treatment programs on these high risk environments.
Resting energy expenditure in Gaucher's disease type 1: effect of Gaucher's cell burden on energy requirements

The resting energy expenditure (REE; kcal/d) of 25 patients with Gaucher's disease type 1 was determined by indirect calorimetry. The average observed REE for the group was approximately 44% greater (P less than .01) than that predicted (predicted REE) for these patient's age, sex, height, and weight. The increased caloric requirements of these patients was manifested by a height-for-age less than or equal to the fifth percentile in seven of nine growing children and a muscle mass of less than the fifth percentile in 15 of 19 patients studied. The excess REE (observed REE--predicted REE) for individual Gaucher's disease type 1 patients was directly related to their liver volume as estimated from radionuclide scans and to the mass of the spleen as measured at splenectomy. The relationship between spleen mass and excess REE was demonstrated by an average 22.0% decrease in REE following splenectomy in five patients. Based on these data, the metabolic rate of the splenic tissue removed from the patients was calculated to be 96.8 kcal/d/kg, about twofold to threefold less than that of normal splenic tissue. These findings indicate that the elevated REE observed in these patients resulted from the large mass of Gaucher's cells, which although individually hypometabolic, were cumulatively an excessive metabolic burden. Furthermore, they suggest that indirect calorimetry may be a quantitative tool for measuring disease progression and the effect of therapeutic intervention in Gaucher's disease type 1.
Using Sibling Dyads to Understand Career Development

A clinical example is provided that illustrates the use of sibling pairings to understand the career development process.
Dynamic grid deformation using Navier-displacement equation for deforming wings

For dynamic and aeroelastic applications of maneuvering wings, the solid boundaries undergo rigid-body motion and aeroelastic deformation. For rigid-body motion, the conservative fluid dynamics equation, in terms of the Eulerian description, is written in terms of a moving frame of reference, and the problem is solved on a time-independent body-conformed grid. For both rigid-body motion and aeroelastic deformation, the Navier-displacement equation, in terms of the Lagrangian coordinates, is modified for fluid-flow problems. It is used along with the Eulerian description of the conservative fluid dynamics equations to account for the grid deformation.
Determination of activity coefficients of binary liquids by capillary gas chromatography with thermal desorption modulation for direct headspace sampling

Abstract Activity coefficients of the binary liquid mixtures benzene-toluene and acetonechloroform were determined using thermal desorption modulation for direct headspace sampling into a capillary gas chromatograph. A thermal desorption modulator is a short, heated section at the head of the column. An electrical current pulse applied to a thin conductive film heats the modulator section and the stationary phase within it, releasing any retained substances as a concentration pulse which flows into the column. The modulator acts like an automatic and highly reproducible small-volume injector for a continuously flowing sample stream. Short-term relative standard deviations obtained using this technique are approximately 2%.
Interval analysis and fuzzy set theory

An overview of interval analysis, its development, and its relationship to fuzzy set theory is given. Possible areas of further fruitful research are highlighted.
The effect of authority and social influence on eyewitness suggestibility and person recognition

This study investigated the influence of an authority figure on eyewitness identification. Participants watched a staged crime and then were administered a photo lineup by either an authority (policeman) or non-authority figure (civilian). Participants in the authority condition were more likely to choose a lineup member than those in the non-authority condition. There was no effect of authority, however, on the accuracy of the identification decisions. The lack of a deleterious effect suggests that the presence of a police officer during identification procedures does not create an unduly suggestive situation or have undesirable effects on eyewitness identification decisions. Although witnesses' choosing behaviors did not increase the rate of identification errors, the effect of the administrator's authority on choosing was reduced when unbiased instructions (vs. biased instructions) were presented to the witnesses. Thus, support was found for the use of neutral instructions during eyewitness identification procedures.
Zero-Hopf singularity for general delayed differential equations

In this manuscript, we provide a framework for zero-Hopf singularity for general delayed differential equations (DDEs). We formulate the explicit conditions such that zero-Hopf singularity occurs for general DDEs and derive the corresponding normal forms up to the third-order terms. As an application of our framework, we discuss zero-Hopf singularity for a Fitzhugh–Nagumo model with delayed feedback control.
Nonlinear smoothers in two dimensions for environmental data

We present smoothing as an exploratory tool in data analysis, with an emphasis on nonlinear smoothers. Beginning with an underlying model which motivates the need for smoothing, we describe the goals of smoothing and characteristics of good smoothers. We also relate smoothing to the concepts of general fitting, parametric and nonparametric regression, and focus on smoothing two-dimensional data sets such as those that occur with environmental data. To overcome the shortcomings in classical linear smoothers, we propose a nonlinear smoother and demonstrate its performance via simulation. Throughout the article, we illustrate our proposal using data on temperature trends at various monitoring stations across the United States.
Anchoring of protein kinase A facilitates hormone-mediated insulin secretion

Impaired insulin secretion is a characteristic of non-insulin-dependent diabetes mellitus (NIDDM). One possible therapeutic agent for NIDDM is the insulinotropic hormone glucagon-like peptide 1 (GLP-1). GLP-1 stimulates insulin secretion through several mechanisms including activation of protein kinase A (PKA). We now demonstrate that the subcellular targeting of PKA through association with A-kinase-anchoring proteins (AKAPs) facilitates GLP-1-mediated insulin secretion. Disruption of PKA anchoring by the introduction of anchoring inhibitor peptides or expression of soluble AKAP fragments blocks GLP-1 action in primary islets and cAMP-responsive insulin secretion in clonal beta cells (RINm5F). Displacement of PKA also prevented cAMP-mediated elevation of intracellular calcium suggesting that localized PKA phosphorylation events augment calcium flux.
Competition between RNA-binding proteins CELF1 and HuR modulates MYC translation and intestinal epithelium renewal

The mammalian intestinal epithelium is one of the most rapidly self-renewing tissues in the body, and its integrity is preserved through strict regulation. The RNA-binding protein (RBP) ELAV-like family member 1 (CELF1), also referred to as CUG-binding protein 1 (CUGBP1), regulates the stability and translation of target mRNAs and is implicated in many aspects of cellular physiology. We show that CELF1 competes with the RBP HuR to modulate MYC translation and regulates intestinal epithelial homeostasis. Growth inhibition of the small intestinal mucosa by fasting in mice was associated with increased CELF1/Myc mRNA association and decreased MYC expression. At the molecular level, CELF1 was found to bind the 3′-untranslated region (UTR) of Myc mRNA and repressed MYC translation without affecting total Myc mRNA levels. HuR interacted with the same Myc 3′-UTR element, and increasing the levels of HuR decreased CELF1 binding to Myc mRNA. In contrast, increasing the concentrations of CELF1 inhibited formation of the [HuR/Myc mRNA] complex. Depletion of cellular polyamines also increased CELF1 and enhanced CELF1 association with Myc mRNA, thus suppressing MYC translation. Moreover, ectopic CELF1 overexpression caused G1-phase growth arrest, whereas CELF1 silencing promoted cell proliferation. These results indicate that CELF1 represses MYC translation by decreasing Myc mRNA association with HuR and provide new insight into the molecular functions of RBPs in the regulation of intestinal mucosal growth.
MIMO floor vibration controller design

The MIMO controller proposed in the paper simultaneously determines optimal placements for multiple actuators, sensors and appropriate output feedback gains. The controller design is carried out in the digital domain hence typically lower sampling rates can be used at the implementation stage. A method of exponentially penalizing the persistent states of the system is used to obtain faster settling times in the presence of external disturbances. The nonlinearities associated with actuator saturation due to force/stroke limitation is considered explicitly in the optimization. The algorithm does not require closed form expressions for modal shapes. Hence it is applicable to a wider class of 2D structures that do not readily fall into any regular geometric shape.
Neurophysiologic evaluation of early cognitive development in high‐risk infants and toddlers

New knowledge of the perceptual, discriminative, and memory capabilities of very young infants has opened the door to further evaluation of these abilities in infants who have risk factors for cognitive impairments. A neurophysiologic technique that has been very useful in this regard is the recording of event-related potentials (ERPs). The event-related potential (ERP) technique is widely used by cognitive neuroscientists to study cognitive abilities such as discrimination, attention, and memory. This method has many attractive attributes for use in infants and children as it is relatively inexpensive, does not require sedation, has excellent temporal resolution, and can be used to evaluate early cognitive development in preverbal infants with limited behavioral repertories. In healthy infants and children, ERPs have been used to gain a further understanding of early cognitive development and the effect of experience on brain function. Recently, ERPs have been used to elucidate atypical memory development in infants of diabetic mothers, difficulties with perception and discrimination of speech sounds in infants at risk for dyslexia, and multiple areas of cognitive differences in extremely premature infants. Atypical findings seen in high-risk infants have correlated with later cognitive outcomes, but the sensitivity and specificity of the technique has not been studied, and thus evaluation of individual infants is not possible at this time. With further research, this technique may be very useful in identifying children with cognitive deficits during infancy. Because even young infants can be examined with ERPs, this technique is likely to be helpful in the development of focused early intervention programs used to improve cognitive function in high-risk infants and toddlers.
Mining relational structure from millions of books: position paper

Existing large-scale scanned book collections have many shortcomings for data-driven research, from OCR of variable quality to the lack of accurate descriptive and structural metadata. We argue that complementary research in inferring relational metadata is important in its own right to support use of these collections and that it can help to mitigate other problems with scanned book collections.
Increasing design space of the instruction queue with tag coding

The instruction queue is a critical component and performance bottleneck in superscalar microprocessors. Conventional designs use physical register identifiers to wake up instructions. This paper proposes decoupling the tags for instruction wakeup from the tags for physical register access, thus increasing the design space of the instruction queue by encoding its operand tags. Two coding methods have been developed. One uses a linear code to increase the Hamming distance between tags, reducing the tag match delay by more than 50% and achieving 12% improvement in the total wakeup/select delay for TSMC 0.18mm technology at 1.8v. The second method uses one-hot code to encode the operand tag, removing the tag OR and tag read operations from the wakeup/select loop. For a 32-entry instruction queue, 15% reduction in the wakeup/select loop has been achieved. Furthermore, one-hot code also removes the dissipation-on-mismatch in the wakeup logic, significantly reducing the dynamic power consumption of the instruction queue.