cssi/SciSciGPT-SciSciNet huggingface dataset:
Late onset asymptomatic pancreatic neuroendocrine tumor – A case report on the phenotypic expansion for MEN1

Multiple endocrine neoplasia type 1 (MEN1) is a hereditary cancer syndrome associated with several endocrine as well as non-endocrine tumors and is caused by mutations in the MEN1 gene. Primary hyperparathyroidism affects the majority of MEN1 individuals by age 50 years. Additionally, MEN1 mutations trigger familial isolated hyperparathyroidism. We describe a seemingly unaffected 76-year-old female who presented to our Genetics Clinic with a family history of primary hyperparathyroidism and the identification of a pathogenic MEN1 variant. The patient was a 76 year-old woman who appeared to be unaffected. She had a family history of a known MEN1 pathogenic variant. Molecular testing for the known MEN1 mutation c.1A > G, as well as, biochemical testing, MRI of the brain and abdomen were all performed using standard methods. Molecular testing revealed our patient possessed the MEN1 pathogenic variant previously identified in her two offspring. Physical exam revealed red facial papules with onset in her seventies, involving her cheeks, nose and upper lip. Formerly, she was diagnosed with rosacea by a dermatologist and noted no improvement with treatment. Clinically, these lesions appeared to be facial angiofibromas. Brain MRI was normal. However, an MRI of her abdomen revealed a 1.5 cm lesion at the tail of the pancreas with normal adrenal glands. Glucagon was mildly elevated and pancreatic polypeptide was nearly seven times the upper limit of the normal range. The patient underwent spleen sparing distal pancreatectomy and subsequent pathology was consistent with a well-differentiated pancreatic neuroendocrine tumor (pNET). Age-related penetrance and variable expressivity are well documented in families with MEN1. It is thought that nearly all individuals with MEN1 manifest disease by age 40. We present a case of late-onset MEN1 in the absence of the most common feature, primary hyperparathyroidism, but with the presence of a pNET and cutaneous findings. This family expands the phenotype associated with the c.1A > G pathogenic variant and highlights the importance of providing comprehensive assessment of MEN1 mutation carriers in families that at first blush may appear to have isolated hyperparathyroidism.
The Scaled Chrysophyte Flora in Freshwater Ponds and Lakes from Newfoundland, Canada, and their Relationship to Environmental Variables

The distributions of scaled chrysophytes in 22 waterbodies from the eastern portion of Newfoundland, Canada, are described relative to environmental gradients. A rich and diverse flora of scaled chrysophytes was recorded that included 47 species from six genera, Mallomonas (n = 29), Synura (n = 7), Neotessella (n = 1), Chrysosphaerella (n = 2), Spiniferomonas (n = 7) and Paraphysomonas (n = 1). Combined with previous works, 57 species of scaled chrysophytes are now known from Newfoundland. On average, 15 species were recorded from each site, and 34 of the taxa were found in more than 10% of the sites. The most widely distributed species were Mallomonas duerrschmidtiae, M. galeiformis, Synura echinulata, S. sphagnicola, and S. petersenii sensu lato, each found in over 75% of the study sites. Seven additional species were found in over 50% of the localities indicating the rich diversity of the flora. One site is of particular significance as it represents the type locality for three species, including Mallomonas newfoundlandicus sp. nov. described in this communication, and represents the northern-most site harboring the marker taxon, M. binocularis. Expanded descriptions of M. maculata and Spiniferomonas abei are given, and evidence is presented that Synura synuroidea represents two distinct species. Overall, the flora reflects habitats that are acidic, dilute and contain moderate to high concentrations of humic substances. Since many of the species are diagnostic bioindicators, these organisms would provide a valuable resource for future paleolimnological studies aimed at understanding impacts from environmental stressors on Newfoundland lakes.
Reverse auction mechanism design for the acquisition of prototyping services in a manufacturing-as-a-service marketplace

Abstract The affordability and increased capability of additive manufacturing machines has spawned prototyping service bureaus throughout the world. This poses a challenge to designers who are looking to obtain quality 3D printed parts at best available prices within fastest turnaround times. Customers relying on a sole source for 3D printed parts may have limited options in obtaining the best deals. From a service supplier point of view, filling excess capacity will require significant marketing budgets to reach and retain customers. In this paper, we present a novel mechanism design approach for improving the accessibility of prototyping services providers by leveraging their excess capacity. In our proposed mechanism, consumers name their own price and the mechanism will find service bureaus who are willing to make the part under the stated price. The mechanism runs similar to a reverse auction where consumers bid and the platform finds a service supplier which is able to match the stated bid price. The incentive for suppliers to participate in such a platform is the opportunity to market their excess capacity to a deal conscious consumer at a lower price without cannibalizing their existing sales channels. Qualified suppliers do not directly compete with each other for any given order since they are chosen using a two stage selection process by the service platform. This algorithm ensures that every supplier has a fair chance of selling its services on the platform regardless of price. We implement the proposed mechanism design approach in a simulated service marketplace and empirically evaluate the marketplace behavior by studying the impact of various model factors such as the supplier threshold price, the size and variety of suppliers in the marketplace.
Case Study Design

Our analysis is broadly framed by the concepts of shared governance and intergovernmental program implementation that are discussed in chapter 2. This chapter addresses our research design for applying these concepts to the study of disaster policy implementation. We begin with our rationale for thinking of disaster policy in terms of shared governance, then consider the selection of the four federal emergency management programs that illustrate different modes of shared governance in our case studies in part II of the book, and finally discuss the selection of states and our procedures for developing the detailed case studies.
A THREE DIMENSIONAL ENERGETIC ANALYSIS OF NORMAL AND PATHOLOGICAL GAIT

Publisher Summary This chapter presents a three-dimensional energetic analysis of normal and pathological gait. The study of the energetics of human motion from a mechanical point of view has been used by many investigators for the elucidation of the mechanisms of both normal and amputee gait. An assumption common to most of these studies has been that of motion restricted to the sagittal plane. In a study described in the chapter, the energetics of pathological gait was of particular interest. As subjects with neurologically based disorders such as cerebral palsy mylomeningocele and stroke whose gait pattern would differ greatly from the norm were to be included in the population to be studied, it was felt that a complete three dimensional analysis of gait energetics would be necessary. The source of kinematic data for this study was motion picture film taken at fifty frames per second. Three cameras were employed. With a computer-aided digitization scheme, the true three-dimensional coordinates of the anatomical points delimiting limb segments were obtained. The coordinates obtained in this way were relative to a fixed laboratory coordinate system whose positive x direction was perpendicular to the direction of walking, positive y direction is parallel to the direction of walking, and positive z direction is vertically upward. The chapter presents some of the results of an energetic analysis for a subject with myelomeningocele. A clinical evaluation of this subject has demonstrated weakness in the gluteus medius, hip flexor, and ankle plantarflexor muscles on the left side.
Induction of lymphocyte proliferation and severe gastrointestinal disease in macaques by a nef gene variant SIVmac239.

Abstract The molecularly cloned virus known as SIVmac239/YEnef causes extensive lymphocyte activation in unstimulated peripheral mononuclear cell cultures and induces an acute disease syndrome in macaque monkeys. Here we describe the histopathological and immunophenotypic changes and viral localization in peripheral lymph nodes, spleen, and gastrointestinal tract (including the gut-associated lymphoid tissue (GALT) in rhesus monkeys inoculated with SIVmac239/YEnet beginning at day 3 postinoculation (pi). The findings are compared with those of rhesus monkeys inoculated with the same dose of parental SIVmac239. Histopathological examination of peripheral lymphoid tissue and GALT demonstrated marked hyperplasia of T-cell-dependent regions and involution of germinal centers as early as day 7 pi. The most striking lesions were multifocal areas of lymphohistiocytic gastroenteritis and colitis. Cellular infiltrates peaked between day 7 and 14 pi and were composed primarily of CD3+ T lymphocytes and HAM-56+ monocyte/macrophages. Many of these inflammatory cells were also strongly immunoreactive for teh nuclear proliferation antigen Ki-67. Despite the presence of severe gastrointestinal pathology by day 7 pi, no significant difference in the numbers of virus-positive cells in the gastrointestinal tract was observed between these animals and SIVmac239-infected animals examined at the same time point. However, the distribution of virus in the gastrointestinal tract was markedly different, with virus localized to lymphoid nodules of GALT in SIVmac239-infected animals and restricted to areas of lymphohistiocytic gastroenteritis and colitis in animals infected with SIVmac239/YEnef. Our data indicate that the acute disease syndrome induced by SIVmac239/YEnef is not simply related to increased viral replication in the gastrointestinal tract but is likely due to inappropriate virus-induced T lymphocyte activation and proliferation in GALT and subsequent mucosal destruction.
The Impact of Late Onset Arterial Hypotension on Respiratory Outcome in Extremely Premature Infants.

BACKGROUND In extremely premature infants, arterial hypotension in the first days after birth has been associated with an increased risk for bronchopulmonary dysplasia (BPD). Some infants present with hypotension at a later postnatal age, but the relationship between late onset hypotension (LOH) and BPD has not been evaluated. OBJECTIVE To evaluate the association between LOH and BPD and to identify pre- and postnatal factors associated with LOH. METHODS Prospectively collected data from a cohort of 23-28 weeks gestational age (GA) infants born during years 2005-2015 and alive at day 28 were analyzed. LOH was defined as the receipt of vasopressor treatment during days 8-28. BPD was defined as need for oxygen at 36 weeks postmenstrual age. Late mortality was defined as death after day 28. RESULTS Of 1,058 infants in the cohort, 90 (9%) had LOH during days 8-28. Infants with LOH had a higher incidence of BPD than normotensive infants (55 vs. 21%, p < 0.001). Multivariate logistic regression analysis (LRA) showed that LOH was associated with an increased risk for BPD (OR 1.87, 95% CI 1.10-3.17). LOH was also associated with an increased risk for late mortality. LRA showed the risk for LOH increased with lower GA, sepsis and patent ductus arteriosus during days 8-28. CONCLUSIONS In this cohort of extremely premature infants, LOH was associated with an increased the risk for BPD. This association could be secondary to underlying factors that predispose to LOH and BPD or to the deleterious effects of LOH or its treatments on the lung. Further investigation is needed to assess causality.
Comparison of cytocentrifugation supernatant fluid and formalin-fixed paraffin-embedded tissue for targeted next-generation sequencing.

Background The emergence of less invasive procedures coupled with the growth of molecular testing have created a need for clinical laboratories to optimize workflows to enable tissue preservation and ancillary testing. In the preparation of formalin-fixed paraffin-embedded cell blocks (FFPE CBs), there is a cytocentrifugation step for cell pellet extraction that results in postcentrifugation supernatant fluid (SN). This SN, which in most routine workflows is discarded, has been suggested to contain adequate cellular material for molecular testing. In the current study, the authors describe the use of DNA and RNA extracted from SN for the detection of clinically relevant biomarkers by next-generation sequencing (NGS). Methods After cell pellet removal, cytocentrifugation SN from 30 endobronchial fine-needle aspiration rinses that were positive for malignancy on FFPE CB were collected. DNA and RNA were extracted from the SN and tested using an in-house NGS Solid Tumor Focus Assay. The NGS results were compared with findings from corresponding FFPE samples. Results Testing was successful in all 30 samples. There was 100% concordance between variants observed in the SN and corresponding FFPE specimens, which included 50 single-nucleotide variants, 9 copy number amplifications, 3 structural variants, and 2 indels. Furthermore, there was excellent correlation (correlation coefficient, 0.93) between the variant allele frequency of mutations observed in SN compared with that noted in corresponding FFPE CBs. Conclusions Cytocentrifugation SN is a valuable source for NGS, is comparable to FFPE that preserves tissue for other ancillary testing, and can reduce the failure rate of testing that may result from insufficient material being available in the CB.
Corrigendum to: A Galois Correspondence for Reduced Crossed Products of Simple -algebras by Discrete Groups

This note corrects an error in our paper “A Galois correspondence for reduced crossed products of unital simple -algebras by discrete groups”, http://dx.doi.org/10.4153/CJM-2018-014-6. The main results of the original paper are unchanged.
Multi-Label Emotion Mining From Student Comments

Science, Technology, Engineering, and Mathematics (STEM) education is gaining more attention not today but has been under research, and discussion for the past few decades. Factors that are considered for research include but not limited to the following, culture on campus, teaching and learning models, and student experience in classroom, gender bias, and stereotypes. One of the major factors is the teaching model adopted which have impact on the student learning styles and their experience in the classroom. Teaching models include traditional models, modern flipped class-room models, and active learning approaches. This study focuses on active learning approaches and their impact on students learning and experience. Light-weight team is an active learning approach, in which team members have little direct impact on each other's final grades, with significant long-term socialization. In this work we used data from end of course student evaluation. We propose extend our previous method for assessing the effectiveness of the Light-weight team teaching model, through automatic detection of emotions in student feedback in computer science course by creating multi-label for each text comment. The students are surveyed about their feelings and thoughts about teaching and learning models adopted and student experience in the classroom. Results show that implementation of these methods result in increased positivity in student emotions.
Use of Tobacco Products/Devices for Marijuana Consumption and Association with Substance Use Problems among U.S. Young Adults (2015-2016)

Abstract Introduction Given the increased availability of tobacco products and devices, rising trends of vaping, and changing marijuana policies in the United States (U.S.), this study reports the prevalence of U.S. young adults using tobacco products/devices for marijuana consumption and associations with substance use problems. Methods U.S. nationally representative data from Wave 3 (2015–2016) of the Population Assessment of Tobacco and Health Study were used to assess young adults’ (18–24 years old, unweighted sample = 8453) ever marijuana use and ever use of electronic nicotine delivery systems (ENDS), hookah, or cigars for marijuana consumption. A multinomial logistic regression predicted the Substance Use Problem subscale of the Global Appraisal of Individual Needs inventory categorized into low (0–1), moderate (2–3) and high (4 or more) symptoms. Results Weighted analyses indicated about half of young adults (52.1%) had ever used marijuana. Of this group, the majority (80.1%) ever used any tobacco product/device for marijuana use including: ENDS (24.5%), hookah (25.2%), or cigar (74.0%). Ever use of tobacco products/devices for marijuana significantly predicted moderate (RRR = 1.70, p Conclusions Use of tobacco products/devices for marijuana consumption is common among U.S. young adults and it is associated with substance use problems. A better understanding of how tobacco devices are being used to support use of both substances and the outcomes of co-use are needed to inform policy and public health interventions.
Trending Up: A Cross-Cohort Exploration of STEM Career and Technical Education Participation by Low-Income Students

The ink from the reauthorization of the Perkins Act – the federal policy governing career and technical education (CTE) – in the summer of 2018 is still fresh. This much-needed update builds upon s...
A Qualitative Study of Smoking‐Related Causal Attributions and Risk Perceptions in Cervical Cancer Survivors

Objective The prevalence of smoking among cervical cancer survivors typically exceeds what is found among women in the general population and other cancer survivors. Yet, there is a dearth of literature on risk and protective factors related to smoking among cervical cancer survivors, especially when it comes to identification of variables that are amendable to intervention. To help fill this gap in the literature, this qualitative study examines the nature of smoking-related causal attributions and risk perceptions in cervical cancer survivors who smoked at cancer diagnosis. Methods Participants are 21 female cervical cancer survivors (M=45.7, SD=8.4 years old), all diagnosed in the past five years. Nearly three-quarters of participants reported smoking in the past month. Results Smoking was not uniformly recognized as a cause of cervical cancer (whether in general or participants' own cancer); the link between smoking and lung, head-neck, and other cancers was more readily accepted. Despite generally weak endorsements of causal attributions, many participants reported smoking significantly increases risk for poor clinical (e.g., recurrence) and quality of life (e.g., pain) outcomes after cervical cancer diagnosis. Conclusions Findings suggest cervical cancer survivors may not fully understand or appreciate the role of smoking in cervical cancer risk whereas their beliefs about the role of smoking in cervical cancer prognosis are more well-formed. This study highlights the potential role of causal attributions and risk perceptions in understanding and addressing the smoking-related experience of cervical cancer survivors.
Combating TCP Port Scan Attacks Using Sequential Neural Networks

Port scans are a persistent problem on contemporary communication networks. Typically used as an attack reconnaissance tool, they can also create problems with application performance and throughput. This paper describes an architecture that deploys sequential neural networks (NNs) to classify packets, separate TCP datagrams, determine the type of TCP packet and detect port scans. Sequential networks allow this lengthy task to learn from the current environment and to be broken up into component parts. Following classification, analysis is performed in order to discover scan attempts. We show that neural networks can be used to successfully classify general packetized traffic at recognition rates above 99% and more complex TCP classes at rates that are also above 99%. We demonstrate that this specific communications task can successfully be broken up into smaller work loads. When tested against actual NMAP scan pcap files, this model successfully discovers open ports and the scan attempts with the same high percentage and low false positives.
James Baldwin and the politics of white identity

Efforts to develop a coherent role for white people in racial justice initiatives in the USA are often stymied by the defensiveness, paternalism, and guilt of many white liberals. Such efforts are also undermined by critiques of whiteness that conflate white identity and white supremacy. I address this dilemma by developing an account of antiracist white identity politics, conceived of here as taking responsibility for the effects of being socially defined as white. I locate conceptual resources for this project in James Baldwin’s reflections on tragedy, love, and identity. In contrast to those who invoke Baldwin to argue for abolishing white identity, I make a case for politicizing it. I draw on Baldwin’s articulation of a tragic sensibility to argue that white antiracism requires accepting a morally compromised identity one has not chosen. It also requires accepting that serious efforts to end white supremacy inevitably lead to mistakes, misunderstandings, and counterproductive outcomes. By adopting a tragic perspective on these aspects of white antiracism, white people would become more capable of forging antiracist white identities through robust engagement in struggles for racial justice.
Early liver metastases after "failure" of adjuvant chemotherapy for stage III colorectal cancer: is there a role for additional adjuvant therapy?

Abstract Background The utility of adjuvant chemotherapy after resection of colorectal liver metastasis (CLM) in patients with rapid recurrence after adjuvant chemotherapy for their primary tumor is unclear. The aim of this study was to evaluate the oncologic benefit of adjuvant hepatic arterial plus systemic chemotherapy (HAIC + Sys) in patients with early CLM. Methods A retrospective analysis of patients with early CLM (≤12 months of adjuvant chemotherapy for primary tumor) who received either HAIC + Sys, adjuvant systemic chemotherapy alone (Sys), or active surveillance (Surgery alone) following resection of CLM was performed. Recurrence and survival were compared between treatment groups using Kaplan–Meier methods and Cox proportional hazards models. Results Of 239 patients undergoing resection of early CLM, 79 (33.1%) received HAIC + Sys, 77 (32.2%) received Sys, and 83 (34.7%) had Surgery alone. HAIC + Sys was independently associated with reduced risk of RFS events (adjusted hazard ratio [HRadj]: 0.64, 95%CI:0.44–0.94, p = 0.022) and all-cause mortality (HRadj: 0.54, 95%CI:0.36–0.81, p = 0.003) compared to Surgery alone patients. Largest tumor >5 cm (HRadj: 2.03, 95%CI: 1.41–2.93, p Conclusion Adjuvant HAIC + Sys after resection of early CLM that occur after chemotherapy for node-positive primary is associated with improved outcomes.
Educational Leadership Doctoral Program Evaluation: Student Voice as the Litmus Test:

This study examines students’ perceptions of an Educational Leadership Doctoral Program’s redesign, based on a multi-criteria framework that informed the program’s core values and beliefs to prepar...
Optimization of novel loop-mediated isothermal amplification with colorimetric image analysis for forensic body fluid identification.

Accurate presumptive and confirmatory test use for forensic body fluid identification is essential for gaining contextual information for crime scene investigators. Loop-mediated isothermal amplification (LAMP) is an ideal method for forensic body fluid identification because it is highly specific and generates multi-sized amplicon DNA, and successful amplification results can be read out colorimetrically. Here, we show preliminary data on a LAMP method that rapidly identifies body fluids including venous blood, semen, and saliva, based on colorimetric response and image analysis. The method is designed for easy implementation into forensic casework protocols with minimal disruption to DNA analysis. LAMP naturally increases target specificity due to the use of multiple primers for one target and mRNA targets were used for tissue and human specificity. With colorimetric detection as an inherent part of LAMP, samples that are positive or negative for any of the body fluids are readily identified by image capture and analysis, thus eliminating subjectivity. Results show by using the 3D-printed imaging system specific color ranges can be set for easy determination of body fluids. The resulting color change can be seen in <30 min using a universal temperature and primer concentration for all body fluids. This simple method and imaging system allow for minimal hands-on time with objective image analysis and presents a pathway for creating a new potential method for forensic body fluid identification.
Lean into Clinical Pharmacy: An Experience in Implementing Key Performance Indicators and Gemba Walks into Clinical Pharmacy Services

Purpose: The Lean methodology was applied to clinical metrics by a critical care pharmacy team. The experiences associated with the development and implementation of clinical metrics and their impact on daily workflow are described. Summary: The Lean methodology has been introduced into the healthcare system as a means of process improvement, which can eliminate waste through appropriate medication utilization. At OhioHealth Riverside Methodist Hospital, the department of pharmacy was tasked with the development of clinical metrics after a health system wide Gemba walk was initiated. The pharmacy department's critical care team developed a strategy identifying and evaluating clinical metrics pertaining to their everyday workflow. Each clinical metric was evaluated in accordance with a pre-defined goal. Metrics requiring heavy documentation and those in which the pharmacist does not have autonomous authority to manage were often challenging to implement and were less successful. Throughout this process, the lessons learned focused on generating ideas that were easily documented, evidence-based, and department specific. The critical care team discovered that the outcome of the most successful metrics highlighted clinical pharmacist value and data generated could be used to support funding for additional resources. Conclusion: The critical care pharmacy team developed a streamlined process to implement clinical metrics as means of identifying areas for improvement using the Lean methodology.
Abstract 358: Genetic Determinants of Lower-Extremity Claudication in South Asians

OBJECTIVES: The prevalence of peripheral arterial disease (PAD) in South Asian populations is less than that reported in populations of Western descent despite higher rates of MI and diabetes. This suggests that there may be a different underlying genetic predisposition to PAD in South Asian individuals. This study was designed to investigate the genetic determinants of PAD in a large Pakistani cohort. METHODS: We examined the association between single nucleotide polymorphisms (SNPs) and clinical symptoms of claudication in participants of the Pakistan Risk of Myocardial Infarction Study (PROMIS), a multicenter case-control study of MI in Pakistan, using its 1000-Genome imputed data set. RESULTS: 724 (4.8%) of the 15,570 individuals enrolled in PROMIS had symptoms of claudication. These subjects had an average (SD) age of 56 (9.7) years and 536 (74%) were male. To assess the role of known MI risk loci, 250 kBP regions flanking the 45 reported MI risk SNPs were examined for their association with claudication. No SNP in any of the known MI risk loci met the pre-determined Bonferroni p-value threshold for significance ( CONCLUSIONS: These findings argue for a different genetic risk profile for PAD and CAD in South Asians, supporting the differences in PAD prevalence between this population and those of Western descent. Additionally, they identify numerous novel potential risk loci for PAD. Replication studies are currently underway to validate these findings.
Technique for the localization of intracranially implanted electrodes.

Object The anatomical localization of electrodes in the human brain is important for the interpretation of pathophysiological (epileptifom spikes, seizures) and functional data (stimulation mapping, evoked potentials). Electroencephalography and evoked potentials are volume-conducted field effects that are most easily interpreted with knowledge of the location and topology of adjacent structures, and brain stimulation techniques produce current fields whose effects are highly dependent on the geometry of electrode assemblies in relation to adjacent structures. In this paper, the authors describe a straightforward method for implanted electrode localization, and detail their experience to date with the technique. Methods The described method is based on the coregistration of preoperative MR imaging studies with postimplant CT scans by using standard mutual information optimization of rigid body transformation of the CT to the MR image. Fused images of the MR and thresholded CT images are derived, and elect...
Linking population heterogeneity with poverty: The case of high-income welfare states, 1980-2005

Purpose – This paper aims to examine how population heterogeneity contributes to poverty in 17 high-income Organization for Economic Cooperation and Development countries during 1980-2005. Design/methodology/approach – The operational strategy involves linking poverty with heterogeneity directly as well as indirectly through welfare state policies as a latent variable in a structural equation framework. Findings – Findings support the widely held poverty-reducing roles of welfare state policies. Ethno-racial and religious diversities are found to positively contribute to welfare state policies and, through them, lower poverty, whereas immigration assumes opposite roles. Research limitations/implications – Data limitations on population and especially ethno-racial and religious heterogeneity caution against definitiveness. Originality/value – The findings are useful in understanding the heterogeneity connection of welfare state policies and poverty.
Male and female sexuality attitudes: differences and similarities.

(1986). Male and Female Sexuality Attitudes: Differences and Similarities. Health Education: Vol. 17, No. 1, pp. 8-12.
Social work in health settings: Practice in context

Widely used in social work and health care education courses, Social Work in Health Settings is the most comprehensive text of its kind. It introduces social work students to a range of clients and provides an overview of many social work settings and services in the health arena. If you're a practitioner, you'll find the book useful for examining and evaluating your practice. This second edition features 18 new chapters and chapter subjects and rewritten and updated versions of the 14 chapters which were part of the first edition. As a casebook, Social Work in Health Settings provides you with an excellent opportunity for understanding particular techniques and interventions. You'll find examples from expert practitioners in a variety of health settings and a thorough integration of social work theory and practice that eliminates the need to assign other supplements for undergraduate/graduate sequences in health care. The book will also help you promote discussions of issues that arise when working in particular settings and with certain populations. Social Work in Health Settings presents a framework called practice in context, developed as a tool for teaching and evaluation, that addresses the three dimensions of context thought to have the most direct consequences for the relationship between social worker and client--policy, technology, and organization. The framework is applied to 32 settings (ten more than the first edition!) drawn from services to children and/or families; acute and high-technology care; rehabilitation, long-term intervention and advocacy; mental health care; and care for the frail elderly and hospice care. Social Work in Health Settings enables you, as a social work professional, to understand the context in which your work with clients occurs, in order to interpret and influence the important dimensions of your client contact. This thought-provoking volume will also encourage educators and students to understand the decisions that affect the helping relationship so that the needs of clients can be evaluated and met properly. In this era of managed care, downsizing, and cost-cutting, the approach in Social Work in Health Settings proves more salient than ever before."
Evidence for Emission of Neutral Particles from Cygnus X-3 With Energy Greater Then 3x105 TeV

We report on preliminary results from a cosmic ray anisotropy search using the Fly’s Eye detector.[1] This detector records scintillation light emitted by extensive air showers in the atmosphere. The threshold for observing such showers with good efficiency and long-term stability is 3x105 TeV. Information available from the measurement includes the zenith and azimuthal angles, the impact parameter of the incident particle to the detector, the total energy, and the position of the shower maximum Xmax in the atmosphere.
Evaluation of Embrittlement in a Pressure Vessel Steel by Fracture Reconstruction

Confocal microscopy (CM) and fracture reconstruction (FR), along with mechanical tests and scanning electron microscopy, were used to characterize irradiation embrittlement of a reference A533B pressure vessel steel. Toughness-temperature [K(T)] curves from tests on one-third size, pre-cracked Charpy specimens resemble the results from full sized specimens; however, the small specimen curves are shifted down in temperature and have steeper transition slopes. Cleavage fracture generally occurred by load-shedding pop-ins, arresting at distances which decreased with increasing temperature. The CM/FR measurements showed nucleation of multiple cleavage facets in high-stress regions in front of the crack tip, followed by coalescence into unstable fracture over a small increment of crack opening. At higher temperature and toughness values the damage was confined to the region around the blunting zone due to the limited specimen capacity. In this regime microvoids were also nucleated on inclusion particles. Irradiation shifted the K(T) curve about 95 C at 75 MPa{center_dot}m{sup 1/2}. However, no major differences in the basic cleavage fracture mechanisms were observed. Indeed at low toughness, shifts in the K(T) curve closely reflected temperature differences at a common yield stress in the irradiated versus unirradiated material. Finally, the toughness values estimated from CM/FR measurements of the critical crackmore » tip opening displacement were in good agreement with the results of the mechanical tests.« less
Reissert compound studies. XLI. Synthesis and reactions of the pyrrolo[1,2‐α]quinoxaline reissert compound and its analogs

Reaction of pyrrolo[1,2-α]quinoxaline, either by the phase-transfer catalyst method or by the trimethylsilyl cyanide method, yielded the Reissert compound, 5-benzoyl-4-cyano-4,5-dihydropyrrolo[1,2-α]quinoxaline. This Reissert compound rearranged to 4-benzoylpyrrolo[1,2-α]quinoxaline upon sodium hydride treatment. It also underwent methylation with methyl iodide and sodium hydride. A few Reissert analogs of the pyrroloquinoxaline were also prepared and their reactions studied.
Interactive buckling analysis with finite strips

On presente un procede semi-analytique pour l'etude de phenomenes de flambage interactif dans des structures de plaques prismatiques. La methode combine les concepts de bandes finies et la theorie des interactions de modes
Thermal coupling links to liquid‐only transfer streams: A path for new dividing wall columns

We propose new dividing wall columns (DWCs) that are equivalent to the fully thermally coupled (FTC) configurations. While our method can draw such configurations for any given n-component mixture (n ≥ 3), we discuss in detail the DWCs for ternary and quaternary feed mixtures. A special feature of all the new DWCs is that during operation, they allow independent control of the vapor flow rate in each partitioned zone of the DWC by means that are external to the column. Because of this feature, we believe that the new arrangements presented in this work will enable the FTC configuration to be successfully implemented and optimally operated as a DWC in an industrial setting for any number of components. Also, interesting column arrangements result when a new DWC drawn for an n-component mixture is adapted for the distillation of a mixture containing more than n components. © 2014 American Institute of Chemical Engineers AIChE J, 60: 2949–2961, 2014
A South American fire ant, Solenopsis nr. saevissima, in Guadeloupe, French West Indies

Several species of fire ants, well known for their painful stings, have spread from their native ranges and have become invasive pests, notably Solenopsis geminata, Solenopsis invicta, and Solenopsis richteri. Here, I report the first known exotic spread of another fire ant, Solenopsis nr. saevissima, a South American species now established on the French West Indian island of Guadeloupe. In 2008, I first found this shiny yellow fire ant at Plage de Viard beach on Guadeloupe. Genetic analyses indicated that this species was close to the yellow–brown variant of S. saevissima known only from Western Amazonia, but not an exact match. I returned to Guadeloupe in 2011 and found S. nr. saevissima at Plage de Viard plus five additional sites along a >20 km stretch on the east coast of Basse-Terre, from the Jarry commercial shipping port in the north to Plage Roseau in the south. It seems most likely that S. nr. saevissima arrived in Guadeloupe from South America in a commercial shipment unloaded at the port in Jarry. It is unclear whether this species will develop into a major new problem. Solenopsis nr. saevissima may simply replace another pernicious fire ant, S. geminata, which apparently arrived in Guadeloupe from South America several 100 years ago.
LAPTM5: A Novel Lysosomal-Associated Multispanning Membrane Protein Preferentially Expressed in Hematopoietic Cells ☆

While a large body of knowledge about cell membrane proteins exists, much less is known about the repertoire and function of integral membrane proteins of intracellular organelles. In looking for novel classes of genes that are functionally important to hematopoietic cells, we have cloned the cDNA for a gene preferentially expressed in adult hematopoietic tissues. During embryonic development the gene is expressed in both hematopoietic and nonhematopoietic tissues. In cell lines the gene is expressed specifically in hematopoietic lineages, whereas in normal adult tissues the mRNA is preferentially detected at high levels in lymphoid and myeloid tissues. The predicted protein is a pentaspanner with no homology to known genes and conserved across evolution. Immunocytological and cell fractionation studies with a specific antibody revealed a protein localizing in lysosomes. The gene, provisionally named LAPTM5, maps to chromosome 1p34. The expression pattern of the gene together with preliminary evidence that the protein interacts with ubiquitin indicates that the protein may have a special functional role during embryogenesis and in adult hematopoietic cells.
Computing S (a) using symbolic Monte Carlo

We describe a method for carrying out a computation of the entropy function of the invariant set of a particular class of maps. We illustrate the method for the case of the quadratic and the Feigenbaum map. Elementary consequences of the symbolic dynamics associated with a map f lead to an algorithm that is a novel application of the Monte Carlo method. To sample, we use the fact that the salient features of the thermodynamic properties of the map are captured by its symbolic dynamics. In the symbolic domain, samples are chosen by manipulating character strings, rather than by performing floating-point calculations. Therefore, exact symbolic answers can be obtained by purely combinatorial methods. These symbolic answers then provide a recipe for performing high-precision numerical computations.
Patterns of sustained performance: beginnings, paths and ends

Summary Using the last decade of Center for Research on Security Prices data and the Capital Asset Pricing Model model to compare firms, we assess the origins, paths and destinations of extreme firm performance. We find that firms that will experience a run of persistent superior (inferior) performance are likely to start at a position of inferior (superior) performance, and that the runs of sustained performance are fairly linear. We also find that failed firms follow a path that reveals a resilience to decline rather than an accelerating acceptance of it, whereas extremely successful firms usually accelerated to their apexes. Overall, the results show that there are several distinct and important types of extreme performance that each require further study.
Numerical studies of steady flow dispersion at low Dean number in a gently curving tube

Using both Monte Carlo and numerical techniques, Taylor dispersion in a curved tube at low Dean numbers has been evaluated and the results are in qualitative agreement with those found by Janssen (1976): Dn2Sc is the controlling parameter with Df falling to about 0.2 of its straight-tube value at high values of Dn2Sc. Agreement with available experimental data is generally good. Further, we find that for large Dn2Sc, the transition from convective to diffusive dispersion occurs earlier than in straight-tube flow, but only by a factor of two.
Long-term results of low anterior resection with intersphincteric anastomosis in carcinoma of the lower one-third of the rectum: analysis of 31 patients.

INTRODUCTION: Between 1985 and 1996, 190 patients underwent a low anterior rectal resection with coloanal anastomosis for adenocarcinoma of the lower one-third of the rectum. METHODS: This article reports on 31 (17 males) of these patients with a very low localization of the tumor (distal tumor margin 1.3±0.9 cm above the dentate line). If the function of the sphincter was acceptable and we could exclude tumor infiltration into the sphincter through endosonography, we relocated the resection plane distally into the intersphincteric region to attain an acceptable margin of safety. In all of these cases, it was impossible for us to perform the usual surgical procedure of a mechanical anastomosis by means of a circular stapler. After intersphincteric rectal resection, the anastomosis was handsewn, using interrupted sutures from the perineal approach, 2.5 to 3 cm above the anal verge, implementing Parks' retractor. A protective stoma was performed in all cases. All data were documented prospectively. RESULTS: Complications: Postoperative mortality was 0 percent. Postoperatively, none of the patients showed an indication for relaparotomy. The leakage rate was 48 percent. Only 16 percent later needed additional surgery for anastomotic strictures or for rectovaginal fistulas. Long-term observations showed that the anastomosis healed well in 27 patients (87.1 percent). Four patients (12.9 percent) decided to have a terminal colostomy performed (anastomotic stricture, 3 patients; anorectal incontinence, 1 patient). Follow-up: During the follow-up period of 6.8±3.7 years, six patients (19.4 percent) developed a tumor progression (9.7 percent local recurrences and 12.9 percent distant spread). The five-year survival rate was 79 percent (Dukes A, 100 percent (n=18); Dukes B, 67 percent (n=4); and Dukes C, 44 percent (n=9)). Continence: One-third of patients developed anorectal incontinence for liquid (29.6 percent) or solid stool (3.7 percent). Average stool frequency was 3.3 times per day. Resting pressure decreased significantly by 29 percent (preoperative, 105±37 cm H2O and postoperative, 75±19 cm H2O;P<0.05), whereas squeeze pressure did not change. CONCLUSION: In selected patients with tumors close to the dentate line, an intersphincteric resection of the rectum may help to avoid an abdominoperineal excision of the rectum with a terminal stoma, without any curtailemtn of oncologic standards. A protective stoma for three months is advantageous.
CONTROL THEOREMS OF COHERENT SHEAVES ON SHIMURA VARIETIES OF PEL TYPE

An exact control theorem is proven for nearly ordinary -adic automorphic forms on symplectic and unitary groups over totally real fields if the algebraic group is split at . In particular, a given nearly ordinary holomorphic Hecke eigenform can be lifted to a family of holomorphic Hecke eigenforms indexed by weights of the standard maximal split torus of the group. Their -points of the split torus. The method is applicable to any reductive algebraic groups yielding Shimura varieties of PEL type under mild assumptions on the existence of integral toroidal compactification of the variety. Even in the Hilbert modular case, the result contains something new: freeness of the universal nearly ordinary Hecke algebra over the Iwasawa algebra, which eluded my scrutiny when I studied general theory of the -adic Hecke algebra in the 1980s.AMS 2000 Mathematics subject classification: Primary 11F03; 11F30; 11F33; 11F41; 11F60; 11G15; 11G18
A concise synthesis of the functionalized [5–7–6] tricyclic skeleton of guanacastepene A

Abstract The six membered ring of guanacastepene A was constructed by a Diels–Alder reaction of 1,1,4-trisubstituted diene to set up the correct relative stereochemistry at the C8 quaternary center and the remote C5 stereocenter. In 10 efficient steps from the Diels–Alder adduct 9 , the desired highly functionalized [5–7–6] tricyclic skeleton 2 was synthesized. Key steps involve trimethylsilyl chloride (TMSCl) assisted Michael addition to form enol ether and the usage of the enol ether in the following intramolecular Mukaiyama aldol reaction to form the middle seven membered ring of guanacastepene A.
A review of visualization techniques of biocolloid transport processes at the pore scale under saturated and unsaturated conditions

Abstract Field and column studies of biocolloid transport in porous media have yielded a large body of information, used to design treatment systems, protect water supplies and assess the risk of pathogen contamination. However, the inherent “black-box” approach of these larger scales has resulted in generalizations that sometimes prove inaccurate. Over the past 10–15 years, pore scale visualization techniques have improved substantially, allowing the study of biocolloid transport in saturated and unsaturated porous media at a level that provides a very clear understanding of the processes that govern biocolloid movement. For example, it is now understood that the reduction in pathways for biocolloids as a function of their size leads to earlier breakthrough. Interception of biocolloids by the porous media used to be considered independent of fluid flow velocity, but recent work indicates that there is a relationship between them. The existence of almost stagnant pore water regions within a porous medium can lead to storage of biocolloids, but this process is strongly colloid-size dependent, since larger biocolloids are focused along the central streamlines in the flowing fluid. Interfaces, such as the air–water interface, the soil–water interface and the soil–water–air interface, play a major role in attachment and detachment, with significant implications for risk assessment and system design. Important research questions related to the pore-scale factors that control attachment and detachment are key to furthering our understanding of the transport of biocolloids in porous media.