cssi/SciSciGPT-SciSciNet huggingface dataset:
Quantifying insect predation: a comparison of three methods for estimating daily per capita consumption of two aphidophagous predators.

ABSTRACT Field observation, field cages, and laboratory arenas were compared as methods to estimate daily per capita consumption for larvae of Harmonia axyndis Pallas (Coleoptera: Coccinellidae) and Chrysopa nigricornis Burmeister (Neuroptera: Chrysopidae), the two most abundant predators of Hyalopterus pruni Geoffroy (Hemiptera: Aphididae) in prune orchards in California's Central Valley. Daily per capita consumption increased with larval size, and the highest estimates were obtained from the field observation method and the lowest from the laboratory arena method for both predator species. Possible explanations for differences between estimates for each method are explored in detail, the most important of which is the need to measure both biomass killed and biomass consumed, because H. axyridis consumed nearly all of each prey item, whereas C. nigricornis always killed more biomass than they consumed. This study suggests that the laboratory arena method can lead to underestimation of daily consumption a...
Latent Gammaherpesvirus 68 Infection Induces Distinct Transcriptional Changes in Different Organs

Previous studies identified a role for latent herpesvirus infection in cross-protection against infection and exacerbation of chronic inflammatory diseases. Here, we identified more than 500 genes differentially expressed in spleens, livers, or brains of mice latently infected with gammaherpesvirus 68 and found that distinct sets of genes linked to different pathways were altered in the spleen compared to those in the liver. Several of the most differentially expressed latency-specific genes (e.g., the gamma interferon [IFN-γ], Cxcl9, and Ccl5 genes) are associated with known latency-specific phenotypes. Chronic herpesvirus infection, therefore, significantly alters the transcriptional status of host organs. We speculate that such changes may influence host physiology, the status of the immune system, and disease susceptibility.
The 9 December 2003 Central Virginia Earthquake Sequence: A Compound Earthquake in the Central Virginia Seismic Zone

The 9 December 2003 central Virginia earthquake sequence was a compound earthquake consisting of two nearly identical events occurring about 12 sec apart. The second event is separated by about 300 m from the first event along the azimuth of approximately 195 (±10)°. The source mechanism determined from regional waveform inversion indicates predominantly thrust faulting at a depth of approximately 10 (±2) km. The sequence with two events attained the combined seismic moment of M 0 2.64 (±1.01) × 10 15 N m ( M w 4.3). The focal mechanism indicates a subhorizontal P axis trending 301° and plunging 19°. A regional stress model for the central Virginia seismic zone (cvsz) derived from the 9 December 2003 events and 11 previous earthquakes indicates a thrust-faulting stress regime with σ 1 trending 133 (±12)° and plunging 14 (±3)°. The least principal stress axis ( σ 3 ) trends 25 (±10)° and plunges 52 (±3)°. The σ 1 axis is rotated approximately 68° clockwise relative to the average maximum horizontal compressional stress (S Hmax ) direction for eastern North America (approximately 65°). The 9 December 2003 earthquake sequence occurred among the systems of Paleozoic and Mesozoic faults above the southern Appalachian decollement, which is at depths from 12 to 19 km in the Piedmont geologic province of central Virginia.
Phylum- and Class-Specific PCR Primers for General Microbial Community Analysis

Amplification of a particular DNA fragment from a mixture of organisms by PCR is a common first step in methods of examining microbial community structure. The use of group-specific primers in community DNA profiling applications can provide enhanced sensitivity and phylogenetic detail compared to domain-specific primers. Other uses for group-specific primers include quantitative PCR and library screening. The purpose of the present study was to develop several primer sets targeting commonly occurring and important groups. Primers specific for the 16S ribosomal sequences of Alphaproteobacteria, Betaproteobacteria, Bacilli, Actinobacteria, and Planctomycetes and for parts of both the 18S ribosomal sequence and the internal transcribed spacer region of Basidiomycota were examined. Primers were tested by comparison to sequences in the ARB 2003 database, and chosen primers were further tested by cloning and sequencing from soil community DNA. Eighty-five to 100% of the sequences obtained from clone libraries were found to be placed with the groups intended as targets, demonstrating the specificity of the primers under field conditions. It will be important to reevaluate primers over time because of the continual growth of sequence databases and revision of microbial taxonomy.
A Case of Post-Traumatic Cerebrospinal Fluid Rhinorrhea with Encephalocele

Posttraumatic cerebrospinal fluid (CSF) leakage may frequently develop after a skull base frac-ture. A patient with a 1-month history of intermittent watery rhinorrhea was referred to our de-partment from the Department of Neurosurgery. He had been treated for 8 months due to a skull base fracture after a motor vehicle accident. He had undergone cranial trephination due to brain abscess prior to this presentation. On radiologic examination, a large skull base defect with enc-ephalocele was observed. Using the nasal endoscopic approach, we identified a large protruding mass of soft brain tissue with pulsating CSF in the ethmoid roof. CSF lumbar drainage was per-formed in order to reduce the protruding mass by decreasing intracranial pressure. After CSF lum-bar drainage, the protruding brain tissue was returned to the cranial cavity, and the leak site was successfully repaired with septal cartilage and graft material.
A scanning tunneling microscope study of single crystal polyethylene

The scanning tunneling microscope has been used to image single crystal polyethylene lamellae coated with thin Au or Cr overlayers. The images show a variety of different morphologies ranging from single crystal lamella resting on atomically flat, highly oriented pyrolitic graphite substrates to large pyramidal structures formed by a multilayer growth process. Small outgrowth structures were observed on the top surface of many individual lamellae and were found to be in registry with the edge of the underlying “seed” lamella. The STM studies show evidence for sectorization of the single crystal lamella as well as plastic deformation of overlapping lamellae involving c-axis slip.
Transcriptional Regulation of Chemokine Genes: A Link to Pancreatic Islet Inflammation?

Enhanced expression of chemotactic cytokines (aka chemokines) within pancreatic islets likely contributes to islet inflammation by regulating the recruitment and activation of various leukocyte populations, including macrophages, neutrophils, and T-lymphocytes. Because of the powerful actions of these chemokines, precise transcriptional control is required. In this review, we highlight what is known about the signals and mechanisms that govern the transcription of genes encoding specific chemokine proteins in pancreatic islet β-cells, which include contributions from the NF-κB and STAT1 pathways. We further discuss increased chemokine expression in pancreatic islets during autoimmune-mediated and obesity-related development of diabetes.
In vitro interaction of posaconazole with calcineurin inhibitors and sirolimus against zygomycetes

Objectives: Zygomycosis is an uncommon but devastating disease with few therapeutic options. Calcineurin inhibitors and sirolimus (mTOR inhibitor), commonly used in transplant patients as immunosuppressives, have antifungal activity. They are known to demonstrate synergy with triazoles against certain fungi, though limited data exist about their activity against zygomycetes. Our aim was to study the in vitro interaction of posaconazole with calcineurin inhibitors and sirolimus against zygomycetes. Methods: Drug interactions were assessed with chequerboard dilution for posaconazole with calcineurin inhibitors and sirolimus according to the CLSI M38-A2 method for filamentous fungi. Twenty-eight clinical isolates were studied, including Rhizopus arrhizus, Rhizopus microsporus, Rhizomucor pusillus, Mucor sp., Cunninghamella bertholletiae, Myocladus corymbifera and Apophysomyces elegans. Combinations of posaconazole with tacrolimus, cyclosporin A or sirolimus were used. Experiments were performed in duplicate. Mean fractional inhibitory concentration indices were calculated. Results: Posaconazole with calcineurin inhibitors demonstrated consistent synergy against C. bertholletiae, M. corymbifera and A. elegans, whereas synergy or no interaction was primarily observed against R. arrhizus, R. microsporus, R. pusillus and Mucor. Antagonism was seen with the combination of posaconazole and sirolimus. Strain variability was noted among the same species. Conclusions: The clinical significance of these findings is unclear, but further studies are warranted given the potential for concomitant use of these agents in transplant patients treated for zygomycosis.
Strategies to Improve the Robustness of Agglomerative Hierarchical Clustering Under Data Source Variation for Speaker Diarization

Many current state-of-the-art speaker diarization systems exploit agglomerative hierarchical clustering (AHC) as their speaker clustering strategy, due to its simple processing structure and acceptable level of performance. However, AHC is known to suffer from performance robustness under data source variation. In this paper, we address this problem. We specifically focus on the issues associated with the widely used clustering stopping method based on Bayesian information criterion (BIC) and the merging-cluster selection scheme based on generalized likelihood ratio (GLR). First, we propose a novel alternative stopping method for AHC based on information change rate (ICR). Through experiments on several meeting corpora, the proposed method is demonstrated to be more robust to data source variation than the BIC-based one. The average improvement obtained in diarization error rate (DER) by this method is 8.76% (absolute) or 35.77% (relative). We also introduce a selective AHC (SAHC) in the paper, which first runs AHC with the ICR-based stopping method only on speech segments longer than 3 s and then classifies shorter speech segments into one of the clusters given by the initial AHC. This modified version of AHC is motivated by our previous analysis that the proportion of short speech turns (or segments) in a data source is a significant factor contributing to the robustness problem arising in the GLR-based merging-cluster selection scheme. The additional performance improvement obtained by SAHC is 3.45% (absolute) or 14.08% (relative) in terms of averaged DER.
PCB Levels in Humans in an Area of PCB Transformer Recycling

PCB levels in environmental, food, and human samples were determined around a highly PCB-contaminated town (F town), a less contaminated town (P town), and a control town (DXG). There were significant differences in PCB concentrations in the intravenous blood of the mothers and their children living in F, P, and DXG sites. In F town, PCB concentrations in the blood of the mothers averaged 190 μg/kg lipid, as compared to 97 μg/kg lipid in the control site. PCB concentrations in the blood of boys and girls averaged 222 and 153 μg/kg lipid, respectively, in F town. PCB concentrations in the umbilical cord blood averaged 566.8 and 168.2 μg/kg lipid, respectively, in the more seriously (F town) and less seriously (P town) polluted sites. Concentrations in the fetal excreta of the newborns averaged 100.06 and 1.66 μg/kg lipid, respectively, in these sites. PCBs were detected in surface water, underground water, soil, and vegetables, and have spread in a circumference of 30 km from the PCB source and have accumulated in the food chains from surface water to fish and duck eggs and from soil to chickens and pigs. The inhabitants have taken in PCBs through these foods since the 1970s. The results implicate the e-waste recycling operations as having caused elevated PCB levels in the environment and in humans. The elevated exposure levels may have health implications for the next generation.
Physical Therapy in Acute Care: A Clinician's Guide

Malone D, Lindsay KLB, eds. Thorofare, NJ 08086, Slack Inc, 2006, paperback, 704 pp, illus, ISBN: 1-55642-534-1, $52.95. The main objective of this text is to provide a reference on acute care practice for both beginning practitioners and students. Experienced clinicians practicing in a new service line also will benefit from this book. The editors should be applauded for attempting to cover such a complex and ever-evolving area of clinical practice. This book contains 15 chapters and is primarily organized using a systems approach with specific chapters on the cardiopulmonary, neurological, musculoskeletal, visceral organ, integumentary, and immunological systems. The book contains 2 helpful chapters related to medical monitoring of laboratory findings and equipment. Finally, the editors include 2 chapters that address oncology and transplantation, which are special topics and very useful to the acute care practitioner. The majority of the chapters follow a common outline—they begin with a basic introduction on the function of the system that the chapter will cover. There is a brief description of common pathologies and medical management. At the end of the chapters there is a …
Transvaginal progesterone supplementation increases serum insulin-like growth factor-binding protein-1 levels

The objective of this study was to assess the effect, which might be mediated by progesterone-dependent insulin-like growth factor-binding protein-1 (IGFBP-1), of micronized progesterone supplementation through different administration routes (oral or vaginal) on successful pregnancy. A total of 299 anovulatory women were treated with clomiphene citrate (100 mg/day on days 5-9 of the menstrual cycle) to stimulate follicular growth. Human chorionic gonadotropin (hCG, 10,000 IU) was injected intramuscularly when at least one follicle was > 20 mm in diameter as monitored by transvaginal ultrasonography. Micronized progesterone (300 mg/day, at bedtime) was used as supplementation of progesterone randomly by oral (n = 153) or vaginal (n = 146) administration from approximately 36-48 h after hCG administration until the following menstrual period or the 10th week of gestation from the last menstrual period. As a control, 18 apparently healthy females with at least three regular menstrual cycles immediately before the present study were also recruited but no interventions were made. Serum levels of progesterone, IGFBP-1, insulin-like growth factor-I (IGF-I) and insulin were determined on day 8 after hCG administration (day 0 indicates the day of hCG administration; progesterone supplementation group) or on day 21 of the menstrual cycle (controls). In the midluteal phase higher progesterone and lower IGFBP-1 levels were observed in the serum from patients supplemented with oral progesterone than in those using vaginal progesterone. Total and continuing pregnancy rates were also higher in the patients using oral than in those using vaginal progesterone (p < 0.04, by the zI-test). However, there was no difference in serum IGF-I or insulin level between the groups. It was concluded that oral administration of micronized progesterone at bedtime appears to be a convenient method of luteal supplement, whereas vaginal supplementation during the luteal phase might directly stimulate endometrial production of IGFBP-1, which possibly, in turn, deters embryo implantation and results in a decrease in the pregnancy rate.
Richtmyer-Meshkov Instability In Reactive Mixtures.

This paper analyzes the effect of reactivity on the Richtmyer-Meshkov instability with particular emphasis on the velocity and wave number scaling and on the effect of free detonation instability modes on the interface corrugation rate. The analysis is performed by solving numerically for the first order perturbation generated by the shock-induced acceleration of an initially corrugated interface. The results show a profound effect of the reactivity on both the short time growth rate and the long time linear regime.
Histories and Stories from Chiapas: Border Identities in Southern Mexico.

Histories and Stories from Chiapas: Border Identities in Southern Mexico. R. Aida Hernandez Castillo. Texas: University of Texas Press, 2001. 317 pp.
RNA triphosphatase is essential in Schizosaccharomyces pombe and Candida albicans

Background The first two steps in the capping of cellular mRNAs are catalyzed by the enzymes RNA triphosphatase and RNA guanylyltransferase. Although structural and mechanistic differences between fungal and mammalian RNA triphosphatases recommend this enzyme as a potential antifungal target, it has not been determined if RNA triphosphatase is essential for the growth of fungal species that cause human disease.
Writing for the Instant Messaging and Text Messaging Generation: Using New Literacies to Support Writing Instruction.

Writing, for adolescents who live in an age of digital communication, has taken on new importance and plays a prominent role in the way they socialize, share information, and structure communication. New literacies expand the literacy realm by considering the skills needed to function using media other than the printed page. Internet resources can enhance and expand the writing process by focusing on different writing forms or genres, using video clips of authors to serve as writing mentors, explaining and facilitating the editing and revising processes, and providing publishing opportunities for student writers. This article provides a rationale for the use of new literacies in literacy instruction and explores ways teachers can integrate new literacies into existing writing instruction.
Accuracy of Allergists' Estimation of Anxiety in Children with Food Allergy

U E S D A Y 793 Accuracy of Allergists' Estimation of Anxiety in Children with Food Allergy Melissa Rubes, Anna Podolsky, Nicole Caso, Rachel Annunziato, Scott H. Sicherer, MD, FAAAAI, Eyal Shemesh; Fordham University, Bronx, NY, Mt. Sinai School of Medicine, NY, NY, Mount Sinai School of Medicine, New York, NY. RATIONALE: Anxiety is an important determinant of quality of life in children with food allergy, but it is not clear whether clinicians can accurately identify anxiety in their patients. METHODS: Participants in this studywere 39 food-allergic children aged 8-17 yrs (21 boys and 18 girls). The participating allergists were 5 attending physicians. Patients completed the Screen for Child Anxiety Related Disorders (SCARED), a validated anxiety questionnaire. Allergists completed a questionnaire with the same items, estimating their patient’s responses. RESULTS: Physicians answered that they ‘‘don’t know’’ over 50% of the time to over 80% of the items, demonstrating a lack of confidence in their ability to detect anxiety in their patients. Three clinicians felt confident enough to complete the full questionnaire for some of their patients (12 cases total). Those reports correlated modestly with the child’s responses (r50.61, p50.04). Of the 39 patients, 6 scored above the clinical threshold for anxiety disorders (a score indicating a need for referral), but clinicians gave an ‘‘above threshold’’ score to only one of those patients. CONCLUSIONS: Allergists did not feel that they could estimate anxiety in their patients most of the time. In the minority of cases in which physicians could estimate patients’ anxiety, their result correlated with patients’ report, but clinically anxious patients were not accurately identified. Our results suggest a deficiency in clinicians’ abilities to identifying anxiety in food-allergic children. Anxiety screening and/or physician training may be warranted to address this deficiency.
3 Genetic investigation of limbal squamous cell carcinoma in Haflinger horses

VFA, mmol/L Acetate 30.3 ± 1.0 34.1 ± 1.0 Propionate 8.0 ± 0.4 11.0 ± 0.4 Butyrate 2.3 ± 0.1 3.0 ± 0.1 Total VFA 42.9 ± 1.6 50.2 ± 1.6 Fatty acids, g/100 g C14:0 3.7 ± 0.09 3.7 ± 0.09 C16:0 17.9 ± 0.2 19.6 ± 0.2 C18:0 35.2 ± 0.5 36.9 ± 0.5 trans-10 C18:1 0.5 ± 0.01 0.4 ± 0.01 trans-11 C18:1 7.6 ± 0.2 5.9 ± 0.2 C18:2n-6 3.5 ± 0.1 3.5 ± 0.1 C18:3n-3 1.2 ± 0.08 0.8 ± 0.08 OBCFA 7.9 ± 0.1 9.0 ± 0.1 Total VFA represents acetate, propionate, isobutyrate, butyrate, isovalerate, and valerate. Oddand branched-chain fatty acids, calculated as the sum of isoC14:0, isoC15:0, anteisoC15:0, C15:0, isoC16:0, anteisoC17:0, and C17:0. Abstracts / Journal of Equine Veterinary Science 35 (2015) 383e391 384
An Introduction to Malnutrition in the Intensive Care Unit

Malnutrition is not a simple matter of balance in the critically ill. Many of the manifestations, such as alterations in protein levels and muscle mass, are strictly epiphenomena of disease. By the same token, the presence of these findings signals a significant increase in disease acuity and higher risk for medical/surgical complications and mortality. The understanding of modern concepts related to malnutrition will help the practitioner determine overall prognosis, as well as identifying more accurately the patient best suited for nutritional intervention.
Control of laminar separation on airfoils using dynamic roughness

A high Reynolds number model of vibrating surface roughness is coupled to high a Reynolds number laminar separation model for non-lifting airfoils. It is found that vibrating surface roughness can suppress laminar separation bubbles, irrespective of whether or not there is a hysteresis in the separation. A significant reduction in separation bubble size is observed above a relatively narrow frequency range. In addition, dynamic roughness is found to suppress lower branch Tollmien-Schlichting waves.
Present situation of providing mode of basic occupational health services in Qingpu district of Shanghai

By the comparative analysis of three providing modes of basic occupational health services(BOSH) in Qingpu district of Shanghai,this study deduces that the mode of BOSH provided by public-private partnerships is suit for the development and demands of BOSH in Qingpu district in the future.Based on this result,the article puts forward the general frame work and safeguard measures of public-private partnerships mode of BOSH,which the district and town governments play a leading role,the public health service networks at district-,town-(street-) and village-level are the foundation,the municipal public occupational health services are the support,private occupational health services are the supplement and district-level occupational health professional associations are the platform.
Comparison and evaluation of common mode EMI filter topologies for GaN-based motor drive systems

As many industries look to wide bandgap (WBG) devices to replace Si devices in power applications, their effects on the power converter need to be first understood in full. While the benefits of WBG devices are widely known, including high switching frequency operating capability, the special characteristics of these new devices have the potential to cause other issues, in particular electromagnetic interference/ compatibility (EMI/EMC). In this paper, multiple EMI filter topologies are investigated for a motor drive system utilizing WBG devices, GaN HEMTs. The different topologies are simulated using LTSpice circuit simulation software and the results are analyzed and complied with MATLAB. The tradeoffs of different filter topologies, namely attenuation versus efficiency and ground current, are demonstrated, providing crucial information for system level designers implementing WBG power switching devices.
Lupus Erythematosus in Childhood

Lupus erythematosus in childhood comprises the following distinctive lupus subsets: neonatal lupus erythematosus, systemic lupus erythematosus, discoid lupus erythematosus, subacute cutaneous lupus erythematosus, complement deficiency syndromes with subacute cutaneous lupus lesions, and lupus panniculitis. The clinical features and pathogeneses of each of these lupus syndromes is discussed in this review.
Evidence for molecular alteration of pyruvate kinase as a consequence of erythrocyte aging.

Abstract The youngest and oldest erythrocytes of normal human blood were segregated by buoyant density gradients of BSA. PK in hemolysates of older cells was observed to differ significantly from that in the younger cells by virtue of lowered optimal activity, increased pH optimum, decreased electrophoretic mobility, and elevated Michaelis constant for PEP. The latter was correctable to normal values by small amounts of the activator, fructose diphosphate. The data suggest that molecular changes in this enzyme associated with in vivo cell aging may be one pertinent mechanism of senescence in normal human erythrocytes.
Endotoxin recovery using limulus amebocyte lysate (LAL) assay.

A phenomenon initially reported by Chen and Vinther in 2013 [1], and now commonly referred to as low endotoxin recovery (LER), has prompted the Food and Drug Administration (FDA) to request specific data demonstrating the capability of the LAL BET method (i.e., USP ) to recover endotoxin from spiked samples over time. The results of these spike/hold recovery studies are expected to be included in the Biologics License Applications (BLA) for review by the Center for Drug Evaluation and Research (CDER) Hughes (2014) and Hughes et al. (2015) [2,3]. Such studies involve spiking a known amount of a surrogate endotoxin, such as purified lipopolysaccharide (LPS), into undiluted biological products and then testing at different time points to determine the recovery over time. We report here the experience and learning gained from conducting spike/hold recovery studies for a monoclonal antibody (Mab) product. Results from initial hold studies spiked with purified LPS showed rapid loss of endotoxin activity in the drug substance (DS) and significant batch-to-batch variation in the drug product (DP). After careful review and examination of the experimental details, it was determined that the study design and execution differed from the routine batch release USP BET method with regard to mixing time and sampling scheme. The hold study design was subsequently revised so that the mixing time and sampling were the same as the verified USP BET method used for routine batch release testing. The spike/hold recovery studies were repeated and the results demonstrated that LPS could be consistently recovered over time. These findings highlight the importance of carefully controlling sample preparation procedures in a spike/hold recovery study in order to demonstrate the suitability of using the LAL BET method for endotoxin detection.
Lifetime and Deployment Limits for Mobile, 3D-Perceptual Applications

Low-cost image and depth sensors (RGBD) promise a wealth of new applications as mobile computing devices become aware of the 3D structure of their environs. However, while sensors are now cheap and readily available, the computational demands for even basic 3D services such as model-building and tracking are significant. We assess these requirements of a basic 3D service that would be required to support many proposed 3D applications, building an analytical model calibrated with detailed empirical measurements. Our results show that both cooperative use of ensembles of mobile devices and adaptive 3D sensor data processing are important to bring compute requirements into feasible ranges.
Powdered sugar shake to monitor and oxalic acid treatments to control varroa mites (Varroa destructor Anderson and Trueman) in honey bee (Apis mellifera) colonies

A practical method to control the destructive varroa mite, Varroa destructor Anderson and Trueman in honey bee colonies consisted of monitoring with powdered sugar and treatment with oxalic acid (OA). We tested mite populations within 28 honey bee colonies on adult bees by a using a powdered sugar shake method. Subsequently, the same colonies were treated with 2.9% oxalic acid and 31.9% sucrose-in-water solution (w/w) four times, with a final varroa treatment using Apistan strips. On average 66.10 ± 35.23% and 94.64 ± 9.56% mites were detected using this simple sugar shake method in August and October, 2015. Furthermore, positive correlations were found between relative number of infested honey bees detected by powdered sugar shake and washing bees with alcohol plus soapy water (r = 0.90 and r = 0.62). Temperature and humidity seems to be crucial in determining the effectiveness of the powdered sugar shake method. For control of the mites, four consecutive OA treatments performed during the winter months ...
Clinical impact and value of workstation single sign-on.

Abstract Background CHRISTUS Health began implementation of computer workstation single sign-on (SSO) in 2015. SSO technology utilizes a badge reader placed at each workstation where clinicians swipe or “tap” their identification badges. Objective To assess the impact of SSO implementation in reducing clinician time logging in to various clinical software programs, and in financial savings from migrating to a thin client that enabled replacement of traditional hard drive computer workstations. Methods Following implementation of SSO, a total of 65,202 logins were sampled systematically during a 7 day period among 2256 active clinical end users for time saved in 6 facilities when compared to pre-implementation. Dollar values were assigned to the time saved by 3 groups of clinical end users: physicians, nurses and ancillary service providers. Results The reduction of total clinician login time over the 7 day period showed a net gain of 168.3 h per week of clinician time – 28.1 h (2.3 shifts) per facility per week. Annualized, 1461.2 h of mixed physician and nursing time is liberated per facility per annum (121.8 shifts of 12 h per year). The annual dollar cost savings of this reduction of time expended logging in is $92,146 per hospital per annum and $1,658,745 per annum in the first phase implementation of 18 hospitals. Computer hardware equipment savings due to desktop virtualization increases annual savings to $2,333,745. Qualitative value contributions to clinician satisfaction, reduction in staff turnover, facilitation of adoption of EHR applications, and other benefits of SSO are discussed. Conclusions SSO had a positive impact on clinician efficiency and productivity in the 6 hospitals evaluated, and is an effective and cost-effective method to liberate clinician time from repetitive and time consuming logins to clinical software applications.
Remote Sensing of Snow Water Equivalent Using Coherent Reflection From Satellite Signals of Opportunity: Theoretical Modeling

A model for the remote sensing of snow water equivalent (SWE) using coherent detection of reflected communication satellite “signals of opportunity” is described in this paper. We modeled the snowpack by a layered medium and compute the phase of specularly reflected signals from the snowpack. Phase change of the reflected signal is predicted to be strongly dependent on SWE for dry snow and on snow depth for wet snow. Phase sensitivity to SWE increases with frequency. Reflected signals with frequencies above S-band, however, will experience rapid phase wrapping (360° change) and become more susceptible to fringe washing due to spatial variability of SWE across the footprint. We also examined the impact of snow grain size, snow density, snow layering, ground surface scattering, and incoherent scattering from ice grains embedded in the snowpack, concluding that these factors do not have a substantial impact on the phase-SWE relationship. However, the snow wetness of more than a few percent can make the reflection from air–snow interface dominant, leading to a correlation between phase change and snow depth. To address the path delay due to the ionosphere, dual-frequency observations would have to be considered. Modeling analysis indicates that the coherent change detection is a promising technique for remote sensing of SWE.
Reply to Trakakis and Nagasawa

AbstractNick Trakakis and Yujin Nagasawa (2004) criticise the argument in Almeida and Oppy (2003). According to Trakakis and Nagasawa, we are mistaken in our claim that the sceptical theist response to evidential arguments from evil is unacceptable because it would undermine ordinary moral reasoning. In their view, there is no good reason to think that sceptical theism leads to an objectionable form of moral scepticism. We disagree. In this paper, we explain why we think that the argument of Nagasawa and Trakakis fails to overthrow our objection to sceptical theism.
Water Resources Internship Report: Grand Teton National Park

The objective of this project was to consolidate all previous work on water rights in the park into a single geodatabase that could be updated and built on in the future. Priority areas specifically for this project were Cottonwood and Spread Creeks, with the goal being to identify all water rights and associated ditches being diverted off of these creeks.
Substrate Binding Induces Conformational Changes in a Class A β-lactamase That Prime It for Catalysis

The emergence and dissemination of bacterial resistance to β-lactam antibiotics via β-lactamase enzymes is a serious problem in clinical settings, often leaving few treatment options for infections resulting from multidrug-resistant superbugs. Understanding the catalytic mechanism of β-lactamases is important for developing strategies to overcome resistance. Binding of a substrate in the active site of an enzyme can alter the conformations and pKas of catalytic residues, thereby contributing to enzyme catalysis. Here we report X-ray and neutron crystal structures of the class A Toho-1 β-lactamase in the apo form and an X-ray structure of a Michaelis-like complex with the cephalosporin antibiotic cefotaxime in the active site. Comparison of these structures reveals that substrate binding induces a series of changes. The side chains of conserved residues important in catalysis, Lys73 and Tyr105, and the main chain of Ser130 alter their conformations, with Nζ of Lys73 moving closer to the position of the con...
Nup159 Weakens Gle1 Binding to Dbp5 But Does Not Accelerate ADP Release.

Abstract Dbp5, DDX19 in humans, is an essential DEAD-box protein involved in mRNA export, which has also been linked to other cellular processes, including rRNA export and translation. Dbp5 ATPase activity is regulated by several factors, including RNA, the nucleoporin proteins Nup159 and Gle1, and the endogenous small-molecule inositol hexakisphosphate (InsP6). To better understand how these factors modulate Dbp5 activity and how this modulation relates to in vivo RNA metabolism, a detailed characterization of the Dbp5 mechanochemical cycle in the presence of those regulators individually or together is necessary. In this study, we test the hypothesis that Nup159 controls the ADP-bound state of Dbp5. In addition, the contributions of Mg2+ to the kinetics and thermodynamics of ADP binding to Dbp5 were assessed. Using a solution based in vitro approach, Mg2+ was found to slow ADP and ATP release from Dbp5 and increased the overall ADP and ATP affinities, as observed with other NTPases. Furthermore, Nup159 did not accelerate ADP release, while Gle1 actually slowed ADP release independent of Mg2+. These findings are not consistent with Nup159 acting as a nucleotide exchange factor to promote ADP release and Dbp5 ATPase cycling. Instead, in the presence of Nup159, the interaction between Gle1 and ADP-bound Dbp5 was found to be reduced by ~ 18-fold, suggesting that Nup159 alters the Dbp5–Gle1 interaction to aid Gle1 release from Dbp5.
Zhu Xi’s Cosmology

In the Western tradition, cosmology has carried two principal connotations. First, ontologia generalis, general ontology, which is concerned with the question of the being of beings. The second sense is that associated with the term, scientia universalis, the science of principles. The first type of cosmology is well represented by the project of Martin Heidegger, who pursued the question, ‘‘Why is there something rather than nothing at all?’’ The second type of speculation address the question: ‘‘What kinds of things are there?’’ Whitehead represents this sort of philosophic activity. (Hall and Ames 1987: 199)
Cerebral Venous Sinus Thrombosis: Clinical Outcomes in Medical Management and Mechanical Thrombectomy (P1.206)

Objective: We assessed the clinical outcomes of cerebral venous sinus thrombosis (CVST) patients who underwent mechanical thrombectomy (MT) compared to those treated with anticoagulation (AC) alone. Background: AC is the mainstay treatment for CVST. However, not all patients respond to AC. Patients may benefit from MT, however, there is limited data. Design/Methods: Retrospective analysis of the electronic medical record was performed from January 2012 to July 2017. Those with CVST secondary to infection, trauma, and those without follow-up were excluded. Primary analysis was modified Rankin Score (mRS) within one year. Recanalization was assessed as a secondary outcome. Results: Chart review identified 169 acute CVST patients; 81 were included in the analysis. All were treated with AC. Of these, six underwent MT. Adjusting for age, initial NIH stroke score was higher in the MT group (11 vs 2.5, p = 0.0006). Intracranial hemorrhage was seen at presentation in 67% of the MT group, and 28% of the AC group. Majority of patients with CVST achieved functional independence (85.2% mRS ≤ 2) at follow-up. Patients who presented with an infarction or intracranial hemorrhage had a higher mean mRS at follow-up (infarct 1.9 vs. 0.66, p = 0.034. ICH 2.0 vs. 0.51, p = 0.004). MT group had a higher mean mRS at follow-up (2.7 ± 2.1 vs 0.80 ± 1.5, p = 0.0057). There was no significant difference in recanalization between the two groups. Conclusions: While patients who received MT had a higher mean mRS at follow-up, the initial clinical presentation was worse than those treated with AC alone. The majority of patients achieved functional independence, even with ICH or infarction. MT may be an efficacious therapy in CVST. However, with good clinical outcomes in most patients, it is unclear which patients benefit from MT. Further investigation is ongoing to determine predictors of poor outcomes in CVST. Disclosure: Dr. Vu has nothing to disclose. Dr. Guzik has nothing to disclose. Dr. Neth has nothing to disclose.
Y-90 radioembolization comparative outcomes between solid tumor malignancies: A single institution experience.

e15704Background: Transcatheter arterial radioembolization with Y90 is a locoregional therapy for unresectable hepatic malignancy with a more favorable side effect profile compared to trans-arteria...
Period Motions in a Periodically Forced, Damped Double Pendulum

In this paper, period motions in a periodically forced, damped, double pendulum are analytically predicted through a discrete implicit mapping method. The implicit mapping is established via the discretized differential equation. The corresponding stability and bifurcation conditions of the period motions are predicted through eigenvalue analysis. Numerical simulation of the period motions in the double pendulum is completed from analytical predictions.Copyright © 2018 by ASME
Proceedings of the 3rd ACM SIGSPATIAL PhD Symposium

It is our great pleasure to welcome you to the 3rd ACM SIGSPATIAL PhD Symposium; the Symposium is held in conjunction with the ACM SIGSAPTIAL conference. The PhD Symposium is a forum where PhD students gather with top professors, researchers, and practitioners in the SIGSPATIAL community. It provides an opportunity to both junior and senior PhD students to present their work and receive useful feedback and guidance to help them move forward toward completion of their PhD.
Improved structural elucidation of peptide isomers and their receptors using advanced ion mobility-mass spectrometry

Abstract Ion mobility-mass spectrometry (IM-MS) has emerged as a highly important analytical technique for the structural elucidation of a wide range of biomolecules, including neuropeptides, proteins and protein complexes. However, though the inherent value presented by powerful ion mobility techniques has garnered significant interest and spurred on the development of novel and increasingly powerful IM-MS regimes, modern commercial implementations continually fall short in the effort to fully resolve subtle structural variations of biologically-relevant analytes, including peptide stereoisomers. Presented here is a review of emerging instrumentation, computational strategies, and methods of data analysis vital to the integration and development of IM-MS workflows for structural characterization. Furthermore, we explore the usefulness of ion mobility techniques in probing structurally-critical biomolecules, examining the ability of current methods to elucidate neuropeptide stereoisomers and receptors.
Robotic natural orifice transluminal endoscopic surgery (R-NOTES) in gynecologic surgeries, a case report and review of literature

Background nbsp Natural nbsp Orifice nbsp Transluminal nbsp Endoscopic nbsp Surgery nbsp NOTES nbsp involves accessing the abdominal cavity through a natural orifice It provides easier access for the surgeon has a reduced recovery times and decreases postoperative pain Objective To present an initial experience with robotic natural orifice transluminal surgery R NOTES in gynecology using the da Vinci surgical system Case nbsp We present a case of a year old Asian female Gravida Para with irregular heavy menstrual cycle abnormal uterine bleeding due to uterine leiomyoma AUB L who under went Da Vinci Natural Orifice Transluminal Endoscopic Surgery NOTES total Laparoscopic hysterectomy TLH bilateral salpingectomy BS Lysis of nbsp adhesions nbsp LOA nbsp and nbsp cystoscopy nbsp The nbsp patient nbsp had nbsp uncomplicated nbsp recovery nbsp and postoperative care and was discharged on postoperative day zero Conclusion nbsp Robotic NOTES Total laparoscopic hysterectomy with bilateral salpingectomy is feasible and safe in gynecology patient This approach has the potential for a less morbid and scarless outcome
The Black and White of Greenway: Racially Restrictive Covenants in Manchester, Connecticut

This paper describes the existence, prevalence and content of racially restrictive property covenants in Manchester, Connecticut, including the environment in which they arose, their legal status, their persistence in the land records, and possibilities for nullifying them.
Thyrotoxicosis in a Postpartum Adolescent: A Simulation Case for Emergency Medicine Providers

Introduction Thyroid storm is a rare but life-threatening disease process that may be difficult to recognize and mimics other disease processes. It is critical for the emergency medicine clinician ...
Extending Context Awareness by Anticipating Uncertainty with Enki and Darjeeling

A self-adaptive system (SAS) requires automated planning that alters its behavior to properly operate in dynamic environments. To select a successful adaptation, the SAS must be context aware, which includes knowledge about a system’s internal and environmental conditions, strategies to monitor conditions, and the capability to reason over an adaptation’s relevance to its current conditions. Operational and environmental conditions are subject to foreseeable sources of uncertainty. Processes should be embedded in the SAS that generate data across a diverse set of conditions to investigate such sources and anticipate their conditions. Enki is a technology that applies a genetic algorithm to generate scenarios with diverse conditions. These scenarios should be further investigated to configure adaptations that address unexpected system behavior and failures. Darjeeling, an automated program repair tool can accept generated scenarios as input and apply genetic programming to generate patches from failed tests. Our prior work created a framework to evaluate patches by assessing their risk of requirements violation and their degree of security compliance confidence. In this paper, we incorporate these third-party tools, Enki and Darjeeling, into our framework that employs a MAPE-K loop of a previous assessed example system to extend its context awareness and increases automated capabilities.
Performance Ritual: With Tannis Hugill

This chapter holds a dialogue between dance artist-healer Tannis Hugill and Barbara Bickel exploring their current and past collaborative performance rituals sourced from trance and the practice of Authentic Movement. A trance practice of journeying to meet a double ally is shared at the close of the chapter.
Selective consumption of macroalgal species by herbivorous fishes suggests reduced functional complementarity on a fringing reef in Moorea, French Polynesia

Abstract Worldwide, many coral reefs are at risk of shifting to degraded algal-dominated states, due to compromised ecological conditions. Functional diversity of herbivorous fishes maintains coral reef health and promotes reef resilience to disturbances. Given previous evidence, it appears the functional roles of herbivorous fishes differ across geographical locations, indicating a need for further assessment of macroalgal consumption by herbivorous fishes. We assessed functional diversity by examining foraging behavior of herbivorous fish species on macroalgae on a fringing reef in Moorea, French Polynesia. We video-recorded choice experiments containing seven common macroalgae and used Strauss' linear resource selection index to determine macroalgal selectivities. We used cluster analysis to identify any distinct groups within herbivorous fish species, given the macroalgal species they targeted, and fitted generalized linear mixed-effects models to identify factors that best predicted the number of bites taken on macroalgae. Seven species from 3 fish families/tribes took a total of 956 bites. Fish species differed in their selectivity with some species (Naso lituratus, N. unicornis, Calatomus carolinus) strongly preferring one or two macroalgal species, while other fish species (Acanthurus nigrofuscus, Ctenochaetus striatus, Chlorurus sordidus, Balistapus undulatus) were less selective. This resulted in fish species forming two clusters. Only 3 of 7 macroalgae were preferred by any fish species, with two fish species both preferring the same two macroalgae. The limited differences in fish species' preferences for different macroalgae suggests limited functional complementarity. Two models (macroalgal species identity+fish functional group, macroalgal species identity+fish species) best predicted the number of bites taken on macroalgae compared to models incorporating only a single explanatory factor or fish family. In the context of this Moorean fringing reef, there is greater functional redundancy than complementarity of herbivorous fishes consuming macroalgae, and the fishes grouped together according to their relative selectivity. We observed fish species that are not classified as browsers consuming macroalgae, suggesting diets of herbivorous fishes may be broader than previously thought. Finally, we observed macroalgal selectivities and consumption that differed from previous studies for the same fish species. Our results contribute to the understanding of functional diversity of herbivorous fishes across coral reefs, and also highlight the need for additional research to further elucidate the role of context and functional diversity of herbivorous fishes consuming macroalgae on coral reefs.