cssi/SciSciGPT-SciSciNet huggingface dataset:
Combination effect of bromadiolone with allopurinol

Objective To observe the combination effect of bromadiolone with allopurinol and improve the capability of the bromadiolone.Methods By the stomach pouring and oral feeding way,observing the occurring time of first dead rat and feeding in coefficient Results The occurring time of first dead rat by stomach pouring way:0.005% bromadiolone was the forth day.0.0058% bromadiolone with 0.0056% allopurinol was the second day.The occurring time of first dead rat by oral feeding way:0.005% bromadiolone was the forth day.0.002%~0.005% bromadiolone with 0.04%~0.06% allopurinol were all the third day.The feeding coefficient:0.005% bromadiolone was 1.0.002% bromadiolone with 0.04% allopurinol was 0.92.0.002% bromadiolone with 0.06% allopurinol was 1.49.Conclusion Allopurinol can improve capability of bromadiolone.It can advance the occurring time of first dead rat.When the dosage of allopurinol is above 0.06%,the feeding coefficient can be advanced.
Drug therapy reviews: evaluation of butorphanol tartrate

The chemistry, pharmacology, uses, side effects, pharmacokinetics and dosage of butorphanol tartrate, a narcotic analgesic with antagonist properties, are reviewed. When administered intramuscularly or intravenously, butorphanol tartrate appears to be as effective for relieving moderate to severe pain as are pentazocine, meperidine and morphine. Butorphanol produces sedation more commonly and, at therapeutic dosages, depresses respiration as much as these other narcotic analgesics. A limited number of long-term clinical studies suggest a lower physical dependence liability with butorphanol than with other narcotic analgesics. Butorphanol is more expensive than morphine and, for most patients, offers no significant advantages over morphine for short-term use. Because butorphanol's cardiovascular effects are not completely understood, morphine also remains the drug of choice for pain associated with myocardial infarction.
Charles Herbert Best

Charles Herbert Best was an American-Canadian biochemist and physiologist, most well known for his work in discovering insulin with Frederick Grant Banting at the University of Toronto, Canada. He and Banting worked feverishly in the summer of 1921 under J. J. R. Macleod’s supervision to isolate a pancreatic extract which would lower blood sugar in pancreatectomized diabetic dogs, later to be called insulin. When the Nobel Prize for Physiology in 1923 was awarded to Banting and Macleod and not Best, it generated immediate controversy, and over the years, it would be realized that Best may have been overlooked. Charles Best had a tremendously successful academic career at the University of Toronto not only in carbohydrate metabolism and insulin but he also made several other contributions with important work in choline, histaminase, and heparin.
IBM zEC12 processor subsystem

The IBM zEC12 has a robust, multi-level shared cache hierarchy that is designed to meet the needs of the enterprise class computing environment and represents a significant growth in system capacity and performance from its predecessor.
Heisenberg scaling of imaging resolution by coherent enhancement

Classical imaging works by scattering photons from an object to be imaged, and achieves resolution scaling as $1/\sqrt{t}$, with $t$ the imaging time. By contrast, the laws of quantum mechanics allow one to utilize quantum coherence to obtain imaging resolution that can scale as quickly as $1/t$ -- the so-called ``Heisenberg limit.'' However, ambiguities in the obtained signal often preclude taking full advantage of this quantum enhancement, while imaging techniques designed to be unambiguous often lose this optimal Heisenberg scaling. Here we demonstrate an imaging technique which combines unambiguous detection of the target with Heisenberg scaling of the resolution. We also demonstrate a binary search algorithm which can efficiently locate a coherent target using the technique, resolving a target trapped ion to within 0.3% of the $1/{e}^{2}$ diameter of the excitation beam.
Chiral Perturbation Theory

One of the prime motivators for lattice QCD is its potential to confront experiment in the nonperturbative regime.
Spatial Variability in Light Yields Colimitation of Primary Production by Both Light and Nutrients in a Forested Stream Ecosystem

Colimitation of primary production is increasingly recognized as a dominant process across aquatic and terrestrial ecosystems. In streams, both nutrient availability and light availability have been shown to independently limit primary production, but colimitation by both light and nutrients is rarely considered. We used a series of nutrient-diffusing substrates (NDS) bioassays deployed across a range of light availability conditions in a single-study stream over two summers to determine the light level at which the limiting factor for benthic periphyton accrual transitioned from light to nutrients. Stream periphyton accrual was nutrient-limited in high-light patches, and light-limited in low-light patches, with the transition from being predominantly light-limited to being predominantly nutrient-limited occurring when daily light fluxes exceeded 3.5 mol m−2 day−1. We quantified light at each NDS bioassay location and at 5 m intervals throughout our two adjacent 160 m study reaches—one in structurally complex old-growth riparian forest and one bordered by more uniform second-growth forest. Although both reaches were colimited overall, the resource (light or nutrients) dominating limitation differed between the two riparian forest age/structure conditions. In the old-growth section, about three quarters of the reach was predominantly nutrient-limited, whereas in the second-growth reach only about a quarter of the streambed was nutrient-limited. In this stream, colimitation of benthic periphyton accrual by light and nutrients at the reach scale was an emergent property of the ecosystem that manifested as a result of high heterogeneity in riparian forest structure.
The Effects of Equivalence Class Structure on Test Performances

Nodal distance specifies the number of nodes that separate any two stimuli in an equivalence class. Directionality of training specifies the sample and comparison functions that are served by the stimuli in a class. These parameters define the formal structure of an equivalence class. Four experiments showed that directionality of training influenced likelihood of class formation and the transfer of responding between stimuli in a class. Eight experiments showed that some test performances were inverse functions of the nodal distance, whereas others were direct functions of nodal distance. The effects of nodal distance were transient when only one response was trained to a stimulus in a class and when the effects of between-class contingencies prevailed during a particular test. They were maintained when at least two responses were trained to some stimuli in a class, and when the effects of between-class contingencies were minimized. Effects of nodal distance thus appear to be imparted permanently during the establishment of baseline relations. Their influence on test performance depends on the effects of other contingencies that can overshadow the effects of nodal distance. Test performances, then, reflect the interactive effects of nodal distance and the parameters of training and testing. The data showed that the stimuli in an equivalence class were only partially substitutable for each other. Thus the relatedness of the stimuli in an equivalence class was an inverse function of the nodal distance.
Nitride Semiconductors for Energy Conversion in Photonic Applications

Nitride semiconductors are interesting materials for solar energy energy conversion because they have better solar absorption and electrical transport properties than oxides or fluorides, as well as better scalability than pnictides or chalcogenides [1]. In this presentation, I will describe a few examples of novel nitride semiconductors recently studied in our group for such photonic applications. The specific cases include ZnSnN 2 for photovoltaic electricity generation [2], Sn 3 N 4 and related alloys for photoelectrochemical water splitting [3], as well as defect tolerant binary (e.g. Cu3N [4], [5]) and ternary (e.g. CuTaN 2 [6], [7]) copper nitrides for solar cells. The current challenges and promising directions in the field will be discussed.
Real-time operation of heterogeneous energy storage units

Energy storage systems are becoming a key component in smart grids with increasing renewable penetration. Storage technologies feature diverse capacity, charging, and response specifications. Investment and degradation costs may require charging batteries at multiple timescales, potentially matching the control periods at which grids are dispatched. To this end, a microgrid equipped with slow- and fast-responding batteries is considered here. Energy management decisions are taken at two stages. Slow-responding batteries are dispatched at an hourly resolution with decisions remaining invariant over multiple fast control slots. Building on Lyapunov optimization, slow- and fast-responding batteries are charged based on real-time and data-dependent with quantifiable sub-optimality bounds. Numerical tests using real data demonstrate the advantage of operating heterogeneous batteries.
TRIP13-deficient tubular epithelial cells are susceptible to apoptosis following acute kidney injury

Damage to renal tubular epithelial cells by genetic, environmental, or biological insults can initiate complex signaling mechanisms that promote kidney repair and functional recovery. In this study, we demonstrated that thyroid receptor interacting protein 13 (TRIP13) is a critical modulator of tubular epithelial cell repair following ischemia‐reperfusion injury (IRI), a common type of renal stressor. In Trip13Gt/Gthypomorph mice treated with unilateral renal IRI, persistent tubular epithelial cell damage was determined in the IRI-treated kidney throughout the 168 hours of experimental period compared to the contralateral kidneys. The damaged epithelial cells were associated with increased levels of DNA damage (ɣH2AX) and apoptotic markers (p53, cleaved caspase-7, and TUNEL-positive cells). Correspondingly, TRIP13 was found to directly interact with Tetratricopeptide Repeat Domain 5 (TTC5), a p53 co‐factor, and genetic knockdown of TRIP13 in murine inner medullary collecting duct cells in the presence of hydrogen peroxide showed increased activity of p53 at Serine 15. In all, these studies suggest that insufficient TRIP13 increased the susceptibility of damaged tubular epithelial cells to progress towards apoptotic cell death.
The Low-Birth-Weight Infant

The birth of a low-birth-weight (LBW) infant may result from the termination of pregnancy before its normal completion at 38–42 weeks gestation (the preterm infant), from the birth of an infant whose intrauterine growth has been poor and who is therefore small for gestational age (SGA), or from a combination of the variables length of gestation and weight per gestational age. Whether an infant is born too soon, born too small, or bora both too soon and too small has important implications in terms of etiology, clinical pathology, postnatal growth, and immediate and long-term outcome.
Management of Retinopathy in Incontinentia Pigmenti: A Systematic Review and Update:

Purpose:The objective of this study is to perform a systematic review and provide an update on the diagnosis and management of retinopathy associated with incontinentia pigmenti (IP).Design:This is...
The Handbook of Art and Design Librarianship, 2nd edition. Paul Glassman and Judy Dyki, eds. London, U.K.: Facet Publishing, 2017. 343p. $85.00, £69.95 (ISBN 978-1-78330-200-0).

The Handbook of Art and Design Librarianship , second edition, is a collection of thirty essays by nearly forty experts in the field that offers readers insight and advice on this specialized area of librarianship in exclusively postsecondary environments. Divided into six sections, the chapters consider “Roles and Responsibilities,” “Materials and Collection Management,” “Teaching and Learning,” “Knowledge Creation,” “The Physical Environment,” and “Promotion and Sustainability.” Each section is preceded by a brief paragraph that summarizes what the reader can expect from the following chapters and additionally provides perspective on the given topic within the current professional landscape. Chapters close with a list of references perfect for guiding the interested librarian who wants to learn more.
Controller-aware memory coloring for multicore real-time systems

Memory latencies vary in non-uniform memory access (NUMA) systems so that execution times may become unpredictable in a multicore real-time system. This results in overly conservative scheduling with low utilization due to loose bounds on the worst-case execution time (WCET) of tasks. This work contributes a controller/node-aware memory coloring (CAMC) allocator inside the Linux kernel for the entire address space to reduce access conflicts and latencies by isolating tasks from one another. CAMC improves timing predictability and performance over Linux' buddy allocator and prior coloring methods. It provides core isolation with respect to banks and memory controllers for real-time systems. To our knowledge, this work is first to consider multiple memory controllers in real-time systems, combine them with bank coloring, and assess its performance on a NUMA architecture.
High Resolution Computed Tomography of Diffuse Pediatric Pulmonary Diseases

High resolution computed tomography (HRCT) is used to maximize spatial resolution in the lung. Most authors define this technique as the combined use of images of 1–3 mm collimation and a high spatial frequency (edge-enhancing algorithm), which on many scanners is called the “bone algorithm”. When used together, these two factors result in images of the lung that approximate the appearance of a gross anatomic specimen [1, 2]. Despite intense interest and experience with this technique in diseases affecting adults, there remains little information in the literature regarding application of this technique to diseases of the child’s lung [3–6].
Thermodynamic Foundations of Wetting and Capillary Phenomena

In the third part of the book, we investigate the phenomenon of self-cleaning and nonadhesive surfaces, i.e., the ability of a surface to repel water, organic liquids, and various types of contaminants, including solid, soft, liquid, and organic, as well as microorganisms. This ability is usually a result of the interplay of surface roughness, coating, micro- and nanostructure, capillary effects, surface energy, and adhesive and chemical properties. The central theme of self-cleaning research is the reduction of adhesion between a liquid and a solid. This involves the reduction of adhesion with the contaminant itself (e.g., with an organic liquid) as well as with water, which washes away contaminants when repelled from a solid surface. Three main approaches to self-cleaning involve (1) the Lotus effect (defined as surface roughness-induced superhydrophobicity and self-cleaning), (2) deposition of a superhydrophilic titanium dioxide (titania) film, and (3) underwater oleophobicity.
Map based navigation for autonomous underwater vehicles

In this work, a map based navigation algorithm is developed wherein measured geophysical properties are matched to a priori maps. The objectives is a complete algorithm applicable to a small, power-limited AUV which performs in real time to a required resolution with bounded position error. Interval B-Splines are introduced for the non-linear representation of two-dimensional geophysical parameters that have measurement uncertainty. Fine-scale position determination involves the solution of a system of nonlinear polynomial equations with interval coefficients. This system represents the complete set of possible vehicle locations and is formulated as the intersection of contours established on each map from the simultaneous measurement of associated geophysical parameters. A standard filter mechanisms, based on a bounded interval error model, predicts the position of the vehicle and, therefore, screens extraneous solutions. When multiple solutions are found, a tracking mechanisms is applied until a unique vehicle location is determined.
RDMC: A Reliable RDMA Multicast for Large Objects

Multicast patterns are common in cloud computing and datacenter settings. Applications and infrastructure tools such as Spark frequently move large objects around, update files replicated to multiple nodes, or push new versions of programs to compute nodes. Some applications use replication directly, for example to increase fault-tolerance or achieve parallelism. Implementations of Paxos, block chains and other libraries often employ a hand-built reliable multicast as a primitive. Yet operating systems continue to be focused on point-to-point communication solutions such as TCP or RDMA, a hardware layer with TCP-like semantics that offers zero copy transfers, but lacks a reliable multi-destination transfer capability. Our system, RDMC (RDMA Multicast), offers reliable multicast functionality constructed from RDMA unicast. We discuss design choices, present a theoretical analysis of RDMC's robustness to delays and slow network links, and report on experiments that evaluate RDMC over Mellanox RDMA.
The Agricultural Deities of Q ’Eqchi’ Mayas, Tzuultaq’as: Agricultural Rituals as Historical Obligation and Avatar of the Cultural Reservoir in Rural Lanquín , Alta Verapaz, Guatemala

This study, based on fieldwork in rural Lanquin, Guatemala, discusses cultural continuity and the sense of historicity through agricultural rituals and worship of the agricultural deity Tzuultaq ’as . The place, Lanquin, and the Q’eqchi’ Maya peasant farmers are situated within a two-fold tension and contradiction. Geographically remote in relation to the economic centers in Guatemala, and marginal in infrastructural development, while their cash crop harvests never fail to be effected by the fluctuations of the global market. From the eclectic stance merging both theories of cultural essentialism and constructivism, by juxtaposing the emblematic event of the anti-Monsanto Law movement in 2014 in Guatemala, and by the calendrical cycles of ritual events, routines, and ceremonials in rural Lanquin, the subsistence practices of milpa (corn field) cultivation emerge as a central theme for cultural survival and continuity. The aggregated clusters of ritual processions and the system of symbolism used manifest the Q’eqchi’ peasant thought and practice of sustainability and conservancy in their construction of a modern cultural identity that maintains congruency with the cultural essence of a nativist identity.
Steroidal antibiotics are antimetabolites of Acanthamoeba steroidogenesis with phylogenetic implications

Pathogenic organisms may be sensitive to inhibitors of sterol biosynthesis, which carry antimetabolite properties, through manipulation of the key enzyme, sterol methyltransferase (SMT). Here, we isolated natural suicide substrates of the ergosterol biosynthesis pathway, cholesta-5,7,22,24-tetraenol (CHT) and ergosta-5,7,22,24(28)-tetraenol (ERGT), and demonstrated their interference in Acanthamoeba castellanii steroidogenesis: CHT and ERGT inhibit trophozoite growth (EC50 of 51 nM) without affecting cultured human cell growth. Washout experiments confirmed that the target for vulnerability was SMT. Chemical, kinetic, and protein-binding studies of inhibitors assayed with 24-AcSMT [catalyzing C28-sterol via Δ24(28)-olefin production] and 28-AcSMT [catalyzing C29-sterol via Δ25(27)-olefin production] revealed interrupted partitioning and irreversible complex formation from the conjugated double bond system in the side chain of either analog, particularly with 28-AcSMT. Replacement of active site Tyr62 with Phe or Leu residues involved in cation-π interactions that model product specificity prevented protein inactivation. The alkylating properties and high selective index of 103 for CHT and ERGT against 28-AcSMT are indicative of a new class of steroidal antibiotic that, as an antimetabolite, can limit sterol expansion across phylogeny and provide a novel scaffold in the design of amoebicidal drugs. Animal studies of these suicide substrates can further explore the potential of their antibiotic properties.
Performance and Return to Sport After Hip Arthroscopy for Femoroacetabular Impingement in Professional Athletes Differs Between Sports

Purpose To determine (1) return-to-sport rates for National Football League, Major League Baseball, National Basketball Association, and National Hockey League (NHL) athletes after hip arthroscopy for femoroacetabular impingement syndrome, (2) postoperative return-to-sport rate differences between sports, (3) differences in postoperative career length and games per season, (4) differences in preoperative and postoperative performance, and (5) postoperative performance compared with that of matched control players. Methods Professional athletes who underwent hip arthroscopy for femoroacetabular impingement syndrome were identified. Matched control players were identified by position, age, experience, and performance. Return to sport was defined as playing in at least 1 game after surgery. Continuous variables for each group were compared by using a 2-tailed paired-samples Student t test or χ2 test. A Bonferroni correction was used to control for multiple comparisons with statistical significance defined by a P value Results One hundred seventy-two players (86.4%) (mean age, 28.8 ± 5.2 years) were able to return to sport at an average of 7.1 ± 4.1 months. Athletes played 3.5 ± 2.4 years after surgery without significant differences between sports (P > .002). NHL players who underwent surgery played significantly fewer years (4.4 vs 3.3 years) (P .002). Conclusion The RTS rate for professional athletes after surgery for femoroacetabular impingement syndrome is high. Only NHL athletes had significantly shorter careers and played significantly fewer games per season compared with matched control players, with no difference between sports. NHL athletes had significantly worse postoperative performance compared with preoperative performance, with all other sports demonstrating a career-related decline similar to that of matched control players.
Enhancement of diffusion-limited vaporization rates by condensation within the thermal boundary layer: 1. The critical supersaturation approximation∗

Abstract The general conditions under which condensation within the thermal boundary layer can enhance the diffusion-limited evaporation rates of liquids or solids in cooler environments are examined analytically, based on the notion that condensation occurs where a “critical supersaturation” is achieved. Simple expressions are derived for the expected enhancement in terms of the dimensionless heat of vaporization Λ/RTw the critical supersaturation evaluated at the surface temperature scrit(Tw) ≡ Pv,crit/Pv,eq (Tw), and a parameter governing the temperature dependence of scrit These results clearly display the thermodynamic and transport conditions under which large enhancements can be expected. The facility with which they can be used for absolute predictions and comparison with available data is illustrated for the case of molten iron spheres evaporating into quiescent helium at atmospheric pressure.
Turning Maneuver Effect on Near-Surface Airfield Pavement Responses:

Airport pavement structures experience heavy aircraft tire loading through a localized contact area. Distributed three-dimensionally and non-uniformly, tire-pavement contact stresses directly influ...
From Digital to Blockchain Markets: What Role for Antitrust and Regulation

In the context of antitrust, technology is not the driver of anticompetitive conduct in digital markets, nor is punishing big companies the solution. It is most likely that markets will shift from centralized closed platforms into decentralized, open networks based on blockchain technologies. Blockchain technology built on a consensus mechanism can make intermediaries [or third parties] unnecessary. Antitrust enforcers should encourage the innovation process simply by deterring those intermediaries from engaging in anticompetitive conduct that might slow the innovation process down while providing support to those companies as they often have the best resources and knowledge to increase innovation. On the other hand, although blockchain technology presents the potential for future opportunities, it is far from being perfect; the risk of collusion, for example, is particularly high in private blockchains. Therefore, the success of blockchain relies on the trust of people in this new technology, which if not used appropriately can damage instead of benefit markets and consumers. Similar to the Internet, antitrust enforcers and regulators are essential in developing trust in blockchain and to make decentralized system of democratic markets based on blockchain technology viable.
The effects of danofloxacin and tilmicosin on peripheral neutrophils in healthy cattle, on peripheral neutrophils in cattle with induced Pasteurella haemolytica pneumonia, and on body temperature measured via radiotelemetry in cattle with induced Pasteurella haemolytica pneumonia

Three studies are described in this report. In the first study, the effects of danofloxacin and tilmicosin on neutrophil function were examined in healthy mixed-breed weaned beef heifers. Neutrophils were isolated from peripheral blood samples preand posttreatment. The neutrophil flmction assays performed were: random migration under agarose. Cytochrome C reduction, iodination. Staphylococcus aureus ingestioi., chemotaxis under agarose, and antibody-independent and antibody-dependent cell-mediated cytotoxicity. The results suggest that at therapeutic drug concentrations, danofloxacin and tilmicosin have little clinical effect on bovine neutrophil function. In the second study, a model was developed for the induction of pneumonic pasteurellosis (using 6 x lO' CFU of a log-phase culture of Pasteurella haemolytica intrabronchially) in weaned, pre-conditioned beef calves that consistently produced rectal temperatures of at least 40°C 24 hours after bacterial challenge, a clinical score of >1, and measurable lung consolidation. In the third study, Pasteurella pneumonia was induced in weaned beef heifer calves using the model from the second study, and calves were treated with danofloxacin or tilmicosin. Neutrophils were collected at 3,24 and 48 hours after treatment. Neutrophil function assays were as performed in study 1, and apoptosis was determined using a cell death detection kit. The results suggest that danofloxacin and tilmicosin have no clinically significant effects on neutrophil function or apoptosis. There were also no significant differences in percent lung consolidation among treatments. Significant differences were found between non-challenged calves and the challenged non-treated calves in several neutrophil assays, which were attributed to an effect of the Pasteurella infection. Body temperature was also examined in this study via intravaginally implanted radiotransmitters. Temperatures were monitored prior to challenge
Substance-Related Disorders

The CAGE, developed by J.A. Ewing and B.A. Rouse, is a 4-item interview schedule that assesses alcohol abuse. The name “CAGE” comes from letters in the four questions: cut, annoyed, guilty, eye-opener (Mayfield, McLeod, & Hall, 1974). The CAGE is much briefer than most alcohol screening measures and can therefore serve as a way for health and mental health professionals to quickly screen clients for alcohol abuse as a supplement to assessment for other problems. The CAGE is very widely used in applied settings (Strang, Bradley, & Stockwell, 1989).
Calculation of Right and Left Ventricular Ejection Fraction Using First Pass and Gated Blood-Pool Scans

Right and left ventricular (RV, LV) ejection fractions (EF) were calculated from first-pass and gated blood-pool scans in 19 patients with different cardiac diseases and in 5 normal subjects. Both types of scans were obtained after a single adequate bolus injection of technetium pertechnetate. Ejection-fractions from both data collection modes were calculated with a combination of threshold and second derivative computer algorithms. Right ventricular ejection fraction (RVEF) by first-pass technique was 25 +/- 11.7 (mean +/- s.d.) for patients and 29 +/- 2.9 for controls; and by gated equilibrium scan was 34 +/- 10.3 for patients and 31 +/- 0.9 for controls. Left ventricular ejection fraction (LVEF) by first pass was 28 +/- 11.9 for patients and 38 +/- 9.6 for controls; and by gated equilibrium scan was 40 +/- 12 for patients and 62 +/- 8.9 for controls. Ejection fraction data from first-pass and gated equilibrium scans were analyzed with linear regression techniques. The correlation coefficient for RVEFs by the two methods was 0.46 for patients and 0.99 for controls; for LVEFs it was 0.63 for patients and -0.11 for controls. Although both of these values for patients were statistically significant, there was wide scatter between EF values obtainedmore » with the two methods in the patient group and in the control group for LVEFs. Thus, one method cannot be substituted for the other to provide reproducible and reliable information concerning RV and LV function in patients with cardiac disease, or for LV function in the controls.« less
Course Development on Synchrophasor Applications at the Undergraduate and Graduate Levels

Phasor Measurement Unit (PMU) design and application requires knowledge of various mathematical and electrical engineering fundamentals. The fundamental theories are covered in lower level courses offered at the undergraduate level in a typical electrical engineering and energy related curriculum. Furthermore, laboratory equipment/device based courses help students to improve their practical skills. Since students find experimental, product development and group work related courses more engaging, they are motivated to enroll in such courses. This paper summarizes a PMU design and application course suitable for electrical engineering/renewable energy undergraduate and graduate students. The paper is aimed towards helping course developers who plan to develop similar courses in the future.
Abstract 127: The Lung-Associated Self-Antigen Type V Collagen is Regulated by Nuclear Factor of Activated T Cells Isoform c3 in Chronic Hypoxia

Chronic hypoxia (CH)-induced pulmonary hypertension (PH) is a progressive and often fatal consequence of chronic lung diseases, chronic exposure to high altitude and sleep apnea. PH results from ar...
Health Care Utilization and Pain Outcomes Following Early Imaging for Low Back Pain in Older Adults.

Background: Professional societies have provided inconsistent guidance regarding whether older patients should receive early imaging for low back pain, in the absence of clinical indications. The study assesses the implications of early imaging by evaluating its association with downstream utilization in an elderly population. Methods: Patients were included if they had a Medicare Advantage plan, had claims-based evidence of low back pain in 2014, and lacked conditions justifying early imaging. The outcomes examined were short-term, nonchronic, and chronic opioid use, steroid injections, and spinal surgery in the following 730 days, and persistent low back pain at 180 to 365 days. Morphine dose equivalents of opioid use was used as a measure of intensity. Logistic and γ regressions were used to assess the association between imaging in the first 6 weeks and the outcomes. Results: Among the 57,293 patients meeting inclusion criteria, the mean age was 71.2, and 26,606 (46.4%) received early imaging. Early imaging was associated with increased adjusted odds of short-term (odds ratio [OR], 1.21; 95% CI, 1.15 to 1.28), nonchronic (OR, 1.78; 95% CI, 1.69 to 1.88), and chronic (OR, 1.13; 95% CI, 1.07 to 1.18) opioid use, as well as steroid injections (OR, 2.55; 95% CI, 2.28 to 2.85) and spinal surgery (OR, 3.40; 95% CI, 2.97 to 3.90). Patients that received early imaging were more likely to experience persistent pain (OR, 1.09; 95% CI, 1.05 to 1.14) and used significantly more morphine dose equivalents if they had nonchronic opioid use. Conclusions: Early imaging for low back pain in older individuals was common, and was associated with greater utilization of downstream services and persistent pain.
Development and preclinical pharmacology of a novel dCK inhibitor, DI-87.

Abstract Background Deoxycytidine kinase (dCK) is an essential enzyme for production of nucleotides via the salvage pathway; DI-87 is a novel dCK inhibitor in preclinical development for use in anticancer therapy. The current study utilizes PET imaging to evaluate PK-PD relationships and to determine optimal dosing of the drug. Methods NSG mice bearing CEM tumors had plasma and tumor PK assessed using mass spectrometry following oral administration of DI-87. dCK inhibition was assessed after a single dose of oral DI-87 followed by a [18F]CFA PET probe and PET imaging. Tumor growth inhibition was assessed by orally administering DI-87 with concurrent intraperitoneal thymidine. Results DI-87 had an in vitro EC50 of 10.2 nM with low protein binding. Peak DI-87 concentrations were observed between 1–3 h and 3–9 h in plasma and tumor, respectively, with tumor concentrations less than one third of plasma. Full dCK inhibition, as evaluated by PET imaging, was observed as early as 3 h following 25 mg/kg dosing and was maintained for 12 h, with full recovery of enzyme activity after 36 h. When DI-87 was administered as repeated doses in combination with thymidine, full dCK inhibition was maintained at 12 h (25 mg/kg twice daily dose) and led to maximal tumor growth inhibition. Conclusions DI-87 is a promising new compound for use in combination therapy against tumors expressing dCK. Utilizing a [18F]CFA PET probe targeting the pathway of interest allowed for efficient and accurate identification of the optimal dose for growth inhibition.
Collaborative school leadership: managing a group of schools: 1st ed., by Middlewood, D., Abbott, I. and Robinson, S. 2019. Bloomsbury Academic, ISBN: 978-1-3500-0913-4, London

Drs. Middlewood, Abbott, and Robinson are professors at the Centre for Education Studies at the University of Warwick, UK. In 2015, Drs. Middlewood and Abbott collaborated on a book titled Improvin...
CVShield: Guarding Sensor Data in Connected Vehicle with Trusted Execution Environment

The emerging Connected Vehicle (CV) technology enables vehicles to wirelessly exchange safety and mobility information (e.g., location and speed) with traffic infrastructure and other vehicles. Existing CV applications heavily rely on sensor inputs (e.g., GPS). However, previous work has shown that the attacker can cause severe congestion or increased safety risks by compromising vehicles and broadcasting falsified sensor data. Thus, it is highly desirable to ensure the integrity of sensor data. In this paper, to prevent compromised vehicles from sending falsified sensor data, we propose a system CVShield, which utilizes the recent advances in hardware-assisted security (e.g., ARM TrustZone). CVShield can ensure the integrity of the sensor data from their reading to their transmission at the vehicle side. In general, we relocate all codes that are related to sensor data reading, processing, encapsulation, and transmission from the rich execution environment (REE) into the trusted execution environment (TEE). However, manually extracting code sections is laborious and error-prone. Also, we should minimize the size of the trusted computing base (TCB) in TEE to reduce the attack surface. To achieve these goals, we propose to leverage program slicing to automatically extract code sections and eliminating irrelevant codes in large codebases. Our initial results demonstrate that CVShield can support GPS data reading, and our optimization can eliminate the time overhead introduced by context switches of TrustZone.
Prognostic and predictive effects of circulating and disseminated tumor cells in breast cancer: A National Cancer Database (NCDB) analysis.

1029Background: Alongside other biomarkers, circulating tumor cells (CTCs) and disseminated tumor cells (DTCs) could contribute to our growing understanding of the breast cancer (BC) “liquid biopsy...
Gut Microbial Changes in Diabetic db/db Mice and Recovery of Microbial Diversity upon Pirfenidone Treatment

The leptin receptor-deficient db/db mouse model is an accepted in vivo model to study obesity, type 2 diabetes, and diabetic kidney disease. Healthy gastrointestinal (GI) microbiota has been linked to weight loss, improved glycemic control, and physiological benefits. We investigated the effect of various drugs on the GI microbiota of db/db mice as compared to control db/m mice. Treatment with long-acting pirfenidone (PFD) increased gut microbial diversity in diabetic db/db mice. Firmicutes, the most abundant phylum in db/m mice, decreased significantly in abundance in db/db mice but showed increased abundance with long-acting PFD treatment. Several bacterial taxa, including Lactobacillus and some Bacteroides, were less abundant in db/db mice and more abundant in long-acting-PFD-treated db/db mice. Long-acting PFD treatment reduced the abundance of Akkermansia muciniphila (5%) as compared to db/db mice (~15%). We conclude that gut microbial dysbiosis observed in db/db mice was partially reversed by long-acting PFD treatment and hypothesize that PFD has beneficial effects, in part, via its influence on the gut microbial metabolite profile. In quantitatively assessing urine metabolites, we observed a high abundance of diabetic ketoacidosis biomarkers, including 3-hydroxybutyric acid and acetoacetic acid in db/db mice, which were less abundant in the long-acting-PFD-treated db/db mice.
An optimized protocol for acquiring and processing cryo-EM data of human 26S proteasome with M1-Ub6.

Summary The 26S proteasome is specialized for regulated protein degradation. It is formed by a regulatory particle (RP) that recognizes ubiquitinated substrates and caps a hollow cylindrical core particle (CP) where substrates are proteolyzed. Structural heterogeneity caused by dynamics makes it challenging to observe ubiquitin chains at the RP by cryogenic electron microscopy (cryo-EM). Here, we present a cryo-EM-based protocol we applied to study the human 26S proteasome with ubiquitin chains by using non-cleavable M1-linked hexaubiquitin (M1-Ub6) unanchored to a substrate. For complete details on the use and execution of this protocol, please refer to Chen et al. (2020) .
Strain rate sensitive microstructural evolution in a TRIP assisted high entropy alloy: Experiments, microstructure and modeling

Abstract Compressive response of a novel Fe38·5Mn20Co20Cr15Si5Cu1.5 high entropy alloy with transformation induced plasticity made by laser powder bed fusion was studied at quasi-static, medium and high strain rates. Mechanical response and variation in work hardening rate with strain rate were correlated with γ (f.c.c.) → e (h.c.p.) martensitic transformation, subsequent phase evolution and adiabatic heating. A strong near basal {0 0 0 1} texture observed in the transformed e (h.c.p.) phase after deformation was correlated with the initial texture, γ (f.c.c.) → e (h.c.p.) transformation orientation relationship, as well as the activated deformation mechanisms in e (h.c.p.) phase. The initial c/a ratio of 1.612 for the e (h.c.p.) phase evolved with deformation and this was quantified to understand the propensity of non-basal slip activation. Metastable γ (f.c.c.) dominant microstructure in the as-built alloy enabled excellent hardening via γ (f.c.c.) → e (h.c.p.) transformation accompanied by activation of non-basal slip and twinning. Experimental results were correlated with existing empirical constitutive models such as Johnson-Cook, Modified Zerilli-Armstrong, Khan-Huang-Liang and Khan-Liu; the Khan-Liu model evidenced the best correlation with experimental results.
Neutrino factory and muon collider collaboration R&D program

Abstract The Neutrino Factory and Muon Collider Collaboration (MC) comprises some 140 scientists and engineers located at U.S. National Laboratories and Universities, and at a number of non-U.S. research institutions. In the past year, the MC R&D program has shifted its focus mainly toward the design issues related to the development of a Neutrino Factory based on a muon storage ring. In this paper the status of the R&D activities is described, and future plans are outlined.
Seizure burden in preterm infants and smaller brain volume at term-equivalent age.

Seizures are underrecognized in preterm infants, and little is known about their impact on brain growth. We aimed to define the association between early seizures and subsequent brain growth. Infants 10 s, evolving in frequency/amplitude/morphology, and identified using automated algorithms with manual review. Using T2-weighted images, cortical surface area (CSA) and gyrification index (GI) were calculated and volumes were segmented into five tissue classes: cerebrospinal fluid, gray matter, white matter (WM), deep nuclear gray matter, and cerebellum. Correlations between total seizure burden and tissue-specific volumes were evaluated, controlling for clinical variables of interest. Ninety-nine infants underwent aEEG/MRI assessments (mean GA = 26.3 weeks, birthweight = 899 g). Seizure incidence was 55% with a median of two events; median length = 66 s and mean burden = 285 s. Greater seizure burden was associated with smaller CSA and volumes across all tissue types, most prominently in WM (R2 = −0.603, p < 0.01), even after controlling for confounders. There was no association with GI. Seizures in preterm infants are common and associated with smaller TEA brain volumes. This relationship was strongest for WM and independent of clinical factors.
P012. COVID-19 Restrictions Impact Psychosocial Health Outcomes of Adults with Cardiovascular Disease

Background Individuals with underlying cardiovascular disease (CVD) have an increased vulnerability to COVID-19 and poorer outcomes. Little is known about the impact social distancing guidelines have had on the health behaviors of this population. Objective The purpose of this study was to examine levels of social isolation, anxiety, depression, loneliness, stress, cognitive function, alcohol use, substance use and health appointment engagement pre-pandemic and after social distancing guidelines were initiated among individuals with CVD. Methods A secondary analysis was completed of a cross-sectional study that utilized a web-based survey. The parent sample included 184 participants recruited using social media. Forty-nine participants (27%) reported a history of CVD that included hypertension, heart failure, myocardial infarction and/or peripheral artery disease. Descriptive statistics and Wilcoxon signed-rank tests with Bonferroni correction were used to compare levels of social isolation, anxiety, depression, loneliness, stress, cognitive function, alcohol use, substance use, and delay/canceled healthcare appointments before and during social distancing recommendations. Results The majority of participants with CVD were female (92%), white (94%), college graduates (92 %), working full-time (45%), and living with two or more people (71%). There were significant differences (p Conclusions The COVID-19 pandemic has concerning repercussions on the mental health of individuals with CVD. A heightened awareness by healthcare providers regarding the psychosocial needs of patients with CVD during the COVID-19 pandemic is warranted. The sample in this study is homogenous, limiting generalization, however, telehealth appointments with the above sample emerged as a viable mechanism for providers to interact with individuals with CVD. Psychosocial and biophysical outcomes from telehealth engagements are areas for further investigation.
Using the Arts to Spread Health, Peace and Community Wellbeing in Rural Kenya

This article tells the empirical story of women from seven villages of Kwale, the most southeastern county in the Coast Province of Kenya that borders with Tanzania—Lunga Lunga, Godo, Perani, Umoja, Maasailand, Mpakani and Jirani—as they searched for community health, equity, gender equality and peace on their own terms. This article shows that creative health initiatives can be successfully used as mechanisms for peace building. Since 2010, the Nikumbuke-Health by All Means (N-HbAM) projects from the University of Madison-Wisconsin in the United States, have trained 57 health promoters and 32 female actors on disease prevention and health promotion that have outreached approximately 120,000 inhabitants around the county enhancing unity in diversity, and breaking down the walls of ethnic hostilities and prejudice. Because of its low cost and high effectivity, the United Nations awarded N-HbAM[1] the 2013 Public Service Award as a model of best practice in gender, community development and sustainable wellbeing. [1] In 2013, at the time of the UNPS Award the projects were still called Nikumbuke-Health by Motorbike (N-HbM). The name was changed in 2018 as the projects broadened in scope and geographical location.
Fundamentals of Data Structures in Pascal

This has long been the text of choice for sophomore/junior level data structure courses as well as more advanced courses-no other book offers greater depth or thoroughness. The clear presentation and coherent organization help students learn basic skills and gain a conceptual grasp of algorithm analysis and data structures. The new edition features: A thorough revision of the text to ensure maximum clarity New and updated sections on abstract data types, amortized complexity, and trees A new utility disk containing kev exercise problem routines.
Obtaining a License to Practice Psychology

In a profession that is rich with complexity and virtually boundless in applications, the simplest of facts remains: if you want to practice as a psychologist, you must be licensed to do so. This is true in every state, province, and territory of the USA and Canada. In several states, you may not legally use the title of “psychologist” without a license to practice psychology. Perhaps the most damaging reality is that a license is required by nearly every third-party payer for reimbursement of services. Without the ability to independently receive reimbursement for services, there is very little you can do without a license to practice and earn a sustainable income. Although the primary rationale for the license to practice is protection of the public, it can sometimes feel like yet another hurdle to a new psychologist.
Atomic data needed for far ultraviolet astronomy with HUT and FUSE

I will summarize the spectroscopic capabilities of existing and planned space experiments, including HUT and FUSE, that will obtain spectra of astronomical sources at wavelengths shorter than Lyman-α. The important atomic and molecular data needed to analyze far and extreme ultraviolet spectra that will be obtained with these instruments include accurate wavelengths, oscillator strengths, photoionization cross sections for six important molecules, and, especially, electron collisional excitation cross sections for both low and high stages of ionization.
Laser cooling of a single Hg II ion

Singly ionized mercury ions have been stored in a miniature rf (Paul) quadruple ion trap and observed by means of resonance fluorescence. The trap electrode spacings (~0.5 mm) and rf voltage (~500 V at 20 MHz) were chosen1 so that the Lamb-Dicke criterion could be satisfied for optical transitions on a single-laser-cooled ion. The presence of a single ion was determined by a statistical loading method2; that is, the loading conditions were scaled down to a point where only occasionally would any fluorescence be observed after a loading cycle. With high probability, this fluorescence was due to a single ion. The fluorescence observed was due to spontaneous scattering from a 194-nm cw source (~3-μW power focused to a beam waist of ~20 μm) directed at the ion and tuned near the strongly allowed first resonance line.