cssi/SciSciGPT-SciSciNet huggingface dataset:
Potent protection against H5N1 and H7N9 influenza via childhood hemagglutinin imprinting.

Two zoonotic influenza A viruses (IAV) of global concern, H5N1 and H7N9, exhibit unexplained differences in age distribution of human cases. Using data from all known human cases of these viruses, we show that an individual’s first IAV infection confers lifelong protection against severe disease from novel hemagglutinin (HA) subtypes in the same phylogenetic group. Statistical modeling shows that protective HA imprinting is the crucial explanatory factor, and it provides 75% protection against severe infection and 80% protection against death for both H5N1 and H7N9. Our results enable us to predict age distributions of severe disease for future pandemics and demonstrate that a novel strain’s pandemic potential increases yearly when a group-mismatched HA subtype dominates seasonal influenza circulation. These findings open new frontiers for rational pandemic risk assessment.
Prospects for case-based research on social media

Social media are undoubtedly the most heavily used class of software applications in the world. They also provide a rich environment for case-based research. It would be reasonable to assume, then,...
Making Paris Work

The Paris Agreement was a critical step forward in the global fight against climate change. But even after it has entered into force, it is still unclear how it can achieve its ambitious collective...
Morphology and mechanical properties of nanocrystalline Cu/Ag alloy

Hybrid Monte Carlo/molecular dynamics (MD) simulations are conducted to study the microstructures of nanocrystalline (nc) Cu/Ag alloys with various Ag concentrations. When the Ag concentration is below 50 Ag atoms/nm2, an increase in Ag concentration leads to a gradual growth of monolayer grain boundary (GB) complexions into nanolayer complexions. Above the concentration of 50 Ag atoms/nm2, wetting layers with a bulk crystalline phase are observed. The effects of Ag on mechanical properties and deformation mechanisms of nc Cu/Ag alloys are investigated in MD simulations of uniaxial tension. GB sliding resistance is found to first increase and then decrease with an increase in Ag concentration. Surprisingly, we also find that the dislocation density decreases monotonically with an increase in Ag concentration, which suggests that the grain interiors are softened by the introduction of Ag dopants at GBs. In addition, there is a critical Ag concentration that maximizes flow stress of nc Cu/Ag alloys. The flow stress, GB sliding resistance, and the intragranular dislocation densities become less sensitive to Ag dopants when the grain diameter increases from 5 to 40 nm.
A novel origin of CP violation

We propose the complex group theoretical Clebsch–Gordan coefficients as a novel origin of CP violation. This is manifest in our model based on SU(5) combined with the double tetrahedral group, T′T′. Due to the presence of the doublet representations in T′T′, there exist complex CG coefficients, leading to explicit CP violation in the model, while the Yukawa couplings and the vacuum expectation of the scalar fields remain real. The tri-bimaximal neutrino mixing matrix arises from the CG coefficients of T′T′. In addition to the prediction for θ13∼θc/(32), the model gives rise to a sum rule, tan2θ⊙∼tan2θ⊙,TBM+12θccosδ, which is a consequence of the Georgi–Jarlskog relations in the charged fermion sector. The leptonic Dirac CP violating phase, δlδl, is predicted to be ∼227∘, which turns out to be the value needed to account for the difference between the experimental best fit value for the solar mixing angle and the TBM prediction. The predicted CP violation measures in the quark sector are also consistent with the current experimental data.
Exploring the microstructure manifold: Image texture representations applied to ultrahigh carbon steel microstructures

Abstract We introduce a microstructure dataset focusing on complex, hierarchical structures found in a single Ultrahigh carbon steel under a range of heat treatments. Applying image representations from contemporary computer vision research to these microstructures, we discuss how both supervised and unsupervised machine learning techniques can be used to yield insight into microstructural trends and their relationship to processing conditions. We evaluate and compare keypoint-based and convolutional neural network representations by classifying microstructures according to their primary microconstituent, and by classifying a subset of the microstructures according to the annealing conditions that generated them. Using t-SNE, a nonlinear dimensionality reduction and visualization technique, we demonstrate graphical methods of exploring microstructure and processing datasets, and for understanding and interpreting high-dimensional microstructure representations.
ALLOGRAFT AND BONE SUBSTITUTES: VESTIGIAL ORGANS FOR BONE DEFICIENCY?

Allograft materials have been the mainstay in addressing bone deficiencies in knee and hip replacement and revision surgery for decades because of the associated donor site morbidity of autografts. Bone graft substitutes have been developed to address allograft issues including potential contamination, disease transmission, and availability. Although non-autogenous products have no osteogenic potential, they do have a variable degree of osteoinductive and osteoconductive properties. Unfortunately, there are limited reports regarding use of bone graft substitutes for use in total hip and knee arthroplasty. Bone graft substitutes have most frequently been used as an “extender”, in combination with morsellised allograft, to fill cavitary defects. Incorporation of this bone graft substitute and morsellised allograft combination appears to occur incompletely. Stable implant fixation appears to be a prerequisite for incorporation of bone graft substitutes, as these cannot be relied upon for structural support. Although bone graft substitutes appear to perform satisfactorily as “fillers” for contained cavitary bone defects, ultraporous metal augments have become the preferred method of providing structural support for some defects. In view of their substantial cost, high quality clinical, radiographic and retrieval data regarding performance of bone graft substitutes is needed.
Understanding Ethical Issues of Research Participation From the Perspective of Participating Children and Adolescents: A Systematic Review.

Background The past 20 years have seen distinct shifts in the way the participation of children and adolescents in research is viewed. This has been emphasized by the growing pediatric research enterprise. Additional information on children's and adolescents’ experiences during research participation is needed to better inform researchers on the ethical conduct of research with this vulnerable population. Aims The objective of this analysis was to examine ethical issues in research with children and adolescents from their perspective as participants, including: assent, parental consent, risk perception, impact of research participation, and incentives. Methods This systematic review was conducted per the Long, Godfrey, Randall, Brettle, and Grant framework by means of an iterative searching process. Using the key words “research ethics” and “child or pediatric or adolescent,” PubMed, CINAHL, and EBSCOhost databases were searched to identify articles. Limitations placed on the searches were: English language, year of publication between 2003 and 2014, humans, abstract available, and age birth–18 years. Findings Twenty-three empiric studies were identified and formed the sample. Included studies represented a diverse range of areas of research, methods, settings, sample demographics, authors, and journals. Linking Evidence to Action Even young children demonstrated the ability to understand essential elements of research, although there is variability in children's level of understanding. Trust was a significant contributing factor to children's and adolescents’ participation in research, and also shaped their assessments of risk. Research participation was mainly beneficial for children and adolescents. Incentives were mainly viewed positively, although concerns of possible undue influence were expressed.
Who should be at the top of bottom-up development ? a case study of the national rural livelihoods mission in Rajasthan, India

It is widely acknowledged that top-down support is essential for bottom-up participatory projects to be effectively implemented at scale. However, which level of government, national or sub-national, should be given the responsibility to implement such projects is an open question, with wide variations in practice. This paper analyzes qualitative and quantitative data from a natural experiment in the state of Rajasthan in India, where a large national flagship project that mobilized women into self-help groups for micro-credit and created a women's network for other development activities was implemented in two different ways. Some sub-regions were given to the state government of Rajasthan to manage, while the Government of India centrally managed other sub-regions. The study finds that the nature of top-down management had a large bearing on the nature and quality of local-level facilitation. Centrally and locally managed facilitators formed several groups with similar financial performance. But centrally managed facilitators formed groups that were less likely to engage in collective action, be politically active, and engage with other civil society organizations. These results raise important questions on how responsibilities for participatory development projects should be devolved, and how the nature of management affects the sustainability of bottom-up interventions.
Evolving a Multi-language Object-Oriented Framework: Lessons from .NET

In 2001 Microsoft shipped the first public version of its Common Language Runtime (CLR) and the associated object-oriented .NET Framework. This Framework was designed for use by multiple languages through adherence to a Common Language Specification (CLS). The CLR, the CLS, and the basic level of the .NET Framework are all part of International Standard ISO/IEC 23271. Over 20 programming languages have been implemented on top of the CLR, all providing access to the same .Net Framework, and over 20,000,000 copies have been downloaded since its initial release.
PatternNet: Visual Pattern Mining with Deep Neural Network

Visual patterns represent the discernible regularity in the visual world. They capture the essential nature of visual objects or scenes. Understanding and modeling visual patterns is a fundamental problem in visual recognition that has wide ranging applications. In this paper, we study the problem of visual pattern mining and propose a novel deep neural network architecture called PatternNet for discovering these patterns that are both discriminative and representative. The proposed PatternNet leverages the filters in the last convolution layer of a convolutional neural network to find locally consistent visual patches, and by combining these filters we can effectively discover unique visual patterns. In addition, PatternNet can discover visual patterns efficiently without performing expensive image patch sampling, and this advantage provides an order of magnitude speedup compared to most other approaches. We evaluate the proposed PatternNet subjectively by showing randomly selected visual patterns which are discovered by our method and quantitatively by performing image classification with the identified visual patterns and comparing our performance with the current state-of-the-art. We also directly evaluate the quality of the discovered visual patterns by leveraging the identified patterns as proposed objects in an image and compare with other relevant methods. Our proposed network and procedure, PatterNet, is able to outperform competing methods for the tasks described.
The mysterious overvaluation of KRW in the 1990s

ABSTRACTExisting theories on real exchange rates predict a significant undervaluation of the Korean won (KRW) in the early and mid-1990s. The paper demonstrates why this expectation did not materialize and instead an unprecedentedly large degree of overvaluation took place. Focusing on three variables, namely, financial repression, devaluation pass-through, and policy exhibitionism, the paper examines how the unraveling of the developmental state eventually gave rise to the 1990s’ overvaluation. It argues that the policy exhibitionism of the new civilian government amplified the influence of Chaebol on monetary policies, which in turn created a strong appreciative force to KRW. It also contends that the increasing exchange rate pass-through onto the prices of imported intermediate goods explains why Chaebol did not desire to tame the excessive appreciative trend despite its detrimental effect on their exports. The paper offers policy implications for other state-led, emerging economies.
Transfinitely valued Euclidean domains have arbitrary indecomposable order type

We prove that for every indecomposable ordinal there exists a (transfinitely valued) Euclidean domain whose minimal Euclidean norm is of that order type. Conversely, any such norm must have indecom...
THE SHORT STEM: PROVEN SOLUTION FOR ALL PRIMARY HIPS – OPPOSES

Short stems are an option for primary THR, but these are the technical challenges. Stem anteversion is increased with short stems usually above 20 degrees so cup anteversion must be adjusted lower. Offset is better if increased up to 5 mm more because more bony neck is retained and with increased stem anteversion the greater trochanter is more posterior, and both of these increase the risk of bony impingement. Short stems are best in A bone, okay in B bone, not recommended yet in C bone. With standard stems performing so well use caution for conversion to short stems.
Relating Boolean gate truth tables to one-way functions

We present a schema to build one way functions from a family of Boolean gates. Moreover, we relate characteristics of these Boolean gate truth tables to properties of the derived one-way functions. We believe this to be the first attempt at establishing cryptographic properties from the Boolean cube spaces of the component gates. This schema is then used to build a family of compression functions, which in turn can be used to get block encryption and hash functions. These functions are based on reconfigurable gates. We prove cryptographically relevant properties for these function implementations. Various applications incorporating these one-way functions, specifically memory integrity in processor architecture, are presented.
Ferrofluids and magnetically guided superparamagnetic particles in flows: a review of simulations and modeling

Ferrofluids are typically suspensions of magnetite nanoparticles, and behave as a homogeneous continuum. The ability of the ferrofluid to respond to an external magnetic field in a controllable manner has made it emerge as a smart material in a variety of applications, such as seals, lubricants, electronics cooling, shock absorbers and adaptive optics. Magnetic nanoparticle suspensions have also gained attraction recently in a range of biomedical applications, such as cell separation, hyperthermia, MRI, drug targeting and cancer diagnosis. In this review, we provide an introduction to mathematical modeling of three problems: motion of superparamagnetic nanoparticles in magnetic drug targeting, the motion of a ferrofluid drop consisting of chemically bound nanoparticles without a carrier fluid, and the breakage of a thin film of a ferrofluid.
High-power femtosecond pulses without a modelocked laser

We demonstrate a fiber system that amplifies and compresses pulses from a gain-switched diode. A Mamyshev regenerator shortens the pulses and improves their coherence, enabling subsequent amplification by parabolic pre-shaping. As a result, we are able to control nonlinear effects and generate nearly transform-limited 140-fs pulses with 13-MW peak power—an order-of-magnitude improvement over previous gain-switched diode sources. Seeding with a gain-switched diode results in random fluctuations of 2% in the pulse energy, which future work using known techniques may ameliorate. Further development may allow such systems to compete directly with sources based on modelocked oscillators in some applications while enjoying unparalleled robustness and repetition rate control.
Gambling Attitudes and Financial Misreporting

We investigate whether attitudes toward gambling help explain the occurrence of intentional misreporting. Similar to gambling, some financial reporting choices involve taking deliberate, speculative risks. We predict that in places where gambling is more socially acceptable, managers will be more likely to take financial reporting risks that increase the likelihood the financial statements will need to be restated. To test this prediction, we exploit geographic variation in local gambling attitudes and find that restatements due to intentional misreporting are more common in areas where gambling is more socially acceptable. This association is even stronger in situations where management is under greater pressure to misreport, including when the firm is close to meeting a performance benchmark, experiencing poor financial performance, or under investment-related pressure. Furthermore, these results are robust to numerous tests to address omitted variables and endogeneity. Collectively, these findings suggest gambling attitudes help explain the incidence of intentional misreporting. This article is protected by copyright. All rights reserved.
QCD axion star collapse with the chiral potential

In a previous work, we analyzed collapsing axion stars using the low-energy instanton potential, showing that the total energy is always bounded and that collapsing axion stars do not form black holes. In this paper, we provide a proof that the conclusions are unchanged when using instead the more general chiral potential for QCD axions.
Intraoperative assessment of tumor margins during glioma resection by desorption electrospray ionization-mass spectrometry

Intraoperative desorption electrospray ionization-mass spectrometry (DESI-MS) is used to characterize tissue smears by comparison with a library of DESI mass spectra of pathologically determined tissue types. Measurements are performed in the operating room within 3 min. These mass spectra provide direct information on tumor infiltration into white or gray brain matter based on N-acetylaspartate (NAA) and on membrane-derived complex lipids. The mass spectra also indicate the isocitrate dehydrogenase mutation status of the tumor via detection of 2-hydroxyglutarate, currently assessed postoperatively on biopsied tissue using immunohistochemistry. Intraoperative DESI-MS measurements made at surgeon-defined positions enable assessment of relevant disease state of tissue within the tumor mass and examination of the resection cavity walls for residual tumor. Results for 73 biopsies from 10 surgical resection cases show that DESI-MS allows detection of glioma and estimation of high tumor cell percentage (TCP) at surgical margins with 93% sensitivity and 83% specificity. TCP measurements from NAA are corroborated by indirect measurements based on lipid profiles. Notably, high percentages (>50%) of unresected tumor were found in one-half of the margin biopsy smears, even in cases where postoperative MRI suggested gross total tumor resection. Unresected tumor causes recurrence and malignant progression, as observed within a year in one case examined in this study. These results corroborate the utility of DESI-MS in assessing surgical margins for maximal safe tumor resection. Intraoperative DESI-MS analysis of tissue smears, ex vivo, can be inserted into the current surgical workflow with no alterations. The data underscore the complexity of glioma infiltration.
Ascent Guidance for an Aerospace Plane

Abstract A single-stage vehicle using airbreathing propulsion holds promise for a more economical delivery of payloads to orbit. The utility of the vehicle is contingent on having a guidance capability for flying a near minimum-fuel ascent trajectory. The challenges in ascent guidance are identified via an analysis of the guidance problem relative to that for the U.S. Space Shuttle. Feedback guidance logic for the hypersonic phase of a near-minimum-fuel ascent trajectory is described. The two-time-scale nature of the vehicle translational dynamics allows the translational state space to be decomposed approximately into an invariant slow manifold and an invariant foliation of fast manifolds. Robust near-optimal guidance is synthesized as a composite of the minimum-fuel control on the slow manifold—as determined by the dynamic pressure and heat rate constraints—and a fast, control for robust tracking of the slow manifold in the presence of atmospheric disturbances and modeling errors. The tracking control is designed using feedback linearization and the bandwidth-limited variable structure control method. Simulations indicate the effectiveness of the guidance logic.
Forty-five Years of Man–Machine Systems: History and Trends

Abstract The field of man-machine systems - the analysis and synthesis of systems in which both human and machine interact closely - is a young and barely recognized discipline with an unrelenting array of new challenges. Following a brief review of history and highlights, this paper will characterize some current trends which have profound implications: (I) The removal of the human element up ("super") and away ("tele") from direct and local physical interaction with the process or product; (2) analytical engagement with systems having multiple decision-makers with partially overlapping databases and multi-incompatible objectives; (3) a new acceptance of reported mental events (as contrasted to physically observable behavior) and fuzzy relations (as constrasted to exclusive-set probablistic events); and (A) an emerging equivalence and transformabi1ity relation between computer-based decision aids and normative models of human performance. All of these have been driven, for reasons to be mentioned, by the computer in its various forms as automatic controller and decision aid or expert system
Improving Survival in the Very Young Renal Transplant Recipient

Sixty-one patients ranging in age from 6 weeks to 30 months have undergone renal transplantation over a 19-year period. The overall survival is 80% with a 90% survival in those patients transplanted since 1980 (41 patients). Seventy-five percent of the original allografts have survived with 83% of the last 41 allografts surviving. The unique challenges presented by the very young renal transplant recipient are outlined along with those aspects of management felt to be most important in ensuring a successful outcome.
Natural History of Implantable Cardioverter-Defibrillator Implanted at or after the Age of 70 years in a Veteran Population: A Single Center Study.

Background: The median age of patients in major Implantable Cardioverter-defibrillator (ICD) trials (MUSTT, MADIT-I, MADIT-II, and SCD-HeFT) was 63-67 years; with only 11% ≥70 years. There is little follow-up data on patients over 70 years of age who received an ICD for primary/secondary prevention of sudden cardiac death, particularly for veterans. Objective: The aim of this study was to study the natural history of ICD implantation for veterans over 70 years of age. Methods: We retrospectively reviewed single center ICD data in 216 patients with a mean age at implantation 76 ± 4 years. The ICD indication was primary prevention in 161 patients and secondary prevention in 55 patients. The ICD indication was unavailable in 4 patients. Results: Mean duration of follow up was 1686 ± 1244 days during which 114 (52%) patients died. Of these, 31% died without receiving any appropriate ICD therapy. Overall, 60/216 (28%) received appropriate therapy and 28/216 (13%) received inappropriate therapy. Patients who had ICD implantation for secondary prophylaxis had statistically more (p= 0.02) appropriate therapies compared to patients who had ICD implantation for primary prophylaxis. Indication for implantation and hypertension predicted appropriate therapy, while age at the time of implantation and presence of atrial fibrillation predicted inappropriate therapies. Overall, 7.7% had device related complications. Conclusions: Although 28% septuagenarians in this study received appropriate ICD therapy, they had high rates of mortality, inappropriate therapy, and device complications. ICD implantation in the elderly merits individualized consideration, with higher benefit for secondary prevention.
Economic Impact Analysis of Bridge Construction

Traffic disruption from bridge construction has been reduced to several hours through the development of methods characterized as accelerated bridge construction. Associated risks and additional activities involved in the accelerated construction increase initial project cost. This additional cost is offset by the benefits of reduced mobility impact time. Traditionally, the savings in user cost from reduced mobility impact time are used to justify the additional cost of accelerated construction implementations. This paper presents a comprehensive cost model for bridge construction that incorporates the economic impact on surrounding communities and businesses. This economic impact model incorporates user costs, environmental costs, and business revenue changes. The M-100 over the CN Railroad bridge replacement project in Potterville, Michigan, is presented here as a case study to demonstrate the application of economic impact analysis concepts and procedures. This bridge replacement was the third slide-in...
Motor Reattachment Kinetics Play a Dominant Role in Multimotor-Driven Cargo Transport.

Abstract Kinesin-based cargo transport in cells frequently involves the coordinated activity of multiple motors, including kinesins from different families that move at different speeds. However, compared to the progress at the single-molecule level, mechanisms by which multiple kinesins coordinate their activity during cargo transport are poorly understood. To understand these multimotor coordination mechanisms, defined pairs of kinesin-1 and kinesin-2 motors were assembled on DNA scaffolds and their motility examined in vitro. Although less processive than kinesin-1 at the single-molecule level, addition of kinesin-2 motors more effectively amplified cargo run lengths. By applying the law of total expectation to cargo binding durations in ADP, the kinesin-2 microtubule reattachment rate was shown to be fourfold faster than that of kinesin-1. This difference in microtubule binding rates was also observed in solution by stopped-flow. High-resolution tracking of a gold-nanoparticle-labeled motor with 1 ms and 2 nm precision revealed that kinesin-2 motors detach and rebind to the microtubule much more frequently than does kinesin-1. Finally, compared to cargo transported by two kinesin-1, cargo transported by two kinesin-2 motors more effectively navigated roadblocks on the microtubule track. These results highlight the importance of motor reattachment kinetics during multimotor transport and suggest a coordinated transport model in which kinesin-1 motors step effectively against loads whereas kinesin-2 motors rapidly unbind and rebind to the microtubule. This dynamic tethering by kinesin-2 maintains the cargo near the microtubule and enables effective navigation along crowded microtubules.
Heat Loads Due To Small Penetrations In Multilayer Insulation Blankets

The main penetrations (supports and piping) through multilayer insulation systems for cryogenic tanks have been previously addressed by heat flow measurements. Smaller penetrations due to fasteners and attachments are now experimentally investigated. The use of small pins or plastic garment tag fasteners to ease the handling and construction of multilayer insulation (MLI) blankets goes back many years. While it has long been understood that penetrations and other discontinuities degrade the performance of the MLI blanket, quantification of this degradation has generally been lumped into gross performance multipliers (often called degradation factors or scale factors). Small penetrations contribute both solid conduction and radiation heat transfer paths through the blanket. The conduction is down the stem of the structural element itself while the radiation is through the hole formed during installation of the pin or fastener. Analytical models were developed in conjunction with MLI perforation theory and Fourier's Law. Results of the analytical models are compared to experimental testing performed on a 10 layer MLI blanket with approximately 50 small plastic pins penetrating the test specimen. The pins were installed at ~76-mm spacing inches in both directions to minimize the compounding of thermal effects due to localized compression or lateral heat transfer. The testing was performed using a liquid nitrogen boil-off calorimeter (Cryostat-100) with the standard boundary temperatures of 293 K and 78 K. Results show that the added radiation through the holes is much more significant than the conduction down the fastener. The results are shown to be in agreement with radiation theory for perforated films.
Biologic Agents Are Associated with Excessive Weight Gain in Children with Inflammatory Bowel Disease

Children with active inflammatory bowel disease (IBD) are frequently underweight. Anti-tumor necrosis factor (anti-TNF) agents may induce remission and restore growth. However, its use in other autoimmune diseases has been associated with excess weight gain. Our aim was to examine whether children with IBD could experience excess weight gain. A centralized diagnostic index identified pediatric IBD patients evaluated at our institution who received anti-TNF therapy for at least 1 year between August 1998 and December 2013. Anthropometric data were collected at time of anti-TNF initiation and annually. Excess weight gain was defined as ΔBMI SDS (standard deviation score) where patients were (1) reclassified from “normal” to “overweight/obese,” (2) “overweight” to “obese,” or (2) a final BMI SDS >0 and ΔSDS >0.5. During the study period, 268 children received anti-TNF therapy. Of these, 69 had sufficient follow-up for a median of 29.3 months. Median age at first anti-TNF dose was 12.8 years. At baseline, mean weight SDS was −0.7 (SD 1.4), while mean BMI SDS was −0.6 (1.3). Using baseline BMI SDS, 11.6% were overweight/obese. At last follow-up (LFU), however, the mean ΔBMI SDS was 0.50 (p 0 and ΔSDS >0.5. Pediatric patients with IBD may experience excess weight gain when treated with anti-TNF agents. Monitoring for this side effect is warranted.
Terrorism and the value of proximity to public transportation: Evidence from the 2005 London bombings

Terrorism has become a primary concern for city dwellers around the world. This paper uses the 2005 attacks on the London Tube to provide causal evidence of the negative impact of terrorism on the value of proximity to public transportation. These attacks brought major transit stations into the spotlight as high-risk locations. As a result, surrounding communities became less attractive places in which to live and conduct business. I find that house prices closer to the major transit hubs of London fell by 6% for one year. This shock spread to Manchester as well: house prices closer to major transit hubs dropped by 9–14% for three to four years. I also show that new firms are less likely to locate near major stations after the attacks, particularly those relying on foot traffic. Among incumbent firms, those serving customers in person are most hurt by the attacks.
Shearing in flow environment promotes evolution of social behavior in microbial populations

According to the principle of the ‘survival of the fittest’, selfish individuals should be better off compared to peers that cooperate with each other. Indeed, even though a population of organisms benefits from working together, selfish members can exploit the cooperative behavior of others without doing their part. These ‘cheaters’ then use their advantage to reproduce faster and take over the population. Yet, social cooperation is widespread in the natural world, and occurs in creatures as diverse as bacteria and whales. How can it arise and persist then? One idea is that when individuals form distinct groups, the ones with cheaters will perish. Even though a selfish individual will fare better than the rest of its team, overall, cooperating groups will survive more and reproduce faster; ultimately, they will be favored by evolution. This is called group selection. Here, Uppal and Vural examine how the physical properties of the environment can influence the evolution of social interactions between bacteria. To this end, mathematical models are used to simulate how bacteria grow, evolve and drift in a flowing fluid. These are based on equations worked out from the behavior of real-life populations. The results show that flow patterns in a fluid habitat govern the social behavior of bacteria. When different regions of the fluid are moving at different speeds, ‘shear forces’ are created that cause bacterial colonies to distort and occasionally break apart to form two groups. As such, cooperative groups will rapidly form new cooperating colonies, whereas groups with cheaters will reproduce slower or perish. Furthermore, results show that when different areas of the fluid have different shear forces, social cooperation will only prevail in certain places. This makes it possible to use flow patterns to fine tune social evolution so that cooperating bacteria will be confined in a certain region. Outside of this area, these bacteria would be taken over by cheaters and go extinct. Bacteria are both useful and dangerous to humans: for example, certain species can break down pollutants in the water, when others cause deadly infections. These results show it could be possible to control the activity of these microorganisms to our advantage by changing the flow of the fluids in which they live. More broadly, the simulations developed by Uppal and Vural can be applied to a variety of ecosystems where microscopic organisms inhabit fluids, such as plankton flowing in oceanic currents.
Consumption externalities and growth: Theory and evidence for the United States

Abstract We study a series of growth models in which households’ preferences display ‘jealousy’ or ‘external habits’: a negative dependence on average consumption. We argue that accounting for consumption externalities in growth models requires consideration of both their static and dynamic effects. In a static sense, and as highlighted in the literature, individual households do not internalize the effect of their choices on average consumption. In a dynamic sense, and differently from most of the literature, households do not take into account the effect of changes in average consumption on the evolution of the (shadow-) value of their own wealth. Accordingly, the equilibrium paths of fully endogenous growth models involve inefficiently low savings and growth because of external habits. In semi-endogenous models, consumption externalities have no growth effects but rather level effects on the long-run research intensity. In exogenous growth models, externalities only slow down the convergence to balanced growth. We then use Consumer Expenditure Survey data to test the extent of external habits: our identification relies on a two-stage estimator that uses the Tax Reform Act of 1986 and the Omnibus Budget Reconciliation Act of 1993 as positive and negative consumption shocks to US top incomes, respectively. In the first stage, we use a difference-in-difference approach to exploit the exogenous variation in consumption due to federal tax reform. We then use the predicted values for average within-cohort consumption by income deciles as an instrument to estimate the extent of social preferences in an estimator that is directly comparable with the household policy function implied by our benchmark model. We find highly significant, long-run external effects ranging from 17% to 27%, depending on the model specification. We also find that consumption externalities are not statistically significant at the very top of the income distribution: this finding provides a rationale for saving rates increasing with incomes, and suggests a channel through which income inequality reverberates into wealth inequality.
Who escaped poverty and who was left behind? A non-parametric approach to explore welfare dynamics using cross-sections

This paper proposes a non-parametric adaptation of a recently developed parametric technique to produce point estimates of intra-generational economic mobility in the absence of panel data sets that follow individuals over time. The method predicts past individual income or consumption using time-invariant observable characteristics, which allows the estimation of mobility into and out of poverty, as well as household-level income or consumption growth, from cross-sectional data. The paper validates this method by sampling repeated cross-sections out of actual panel data sets from three countries in the Latin America region and comparing the technique with mobility from panels. Overall, the method performs well in the three settings; with few exceptions, all estimates fall within the 95 percent confidence intervals of the panel mobility. The quality of the estimates does not depend in general on the sophistication level of the underlying welfare model's specifications. The results are encouraging even for those specifications that include few time-invariant variables as regressors.
BLOOD CONSERVATION: PRE-, PERI- AND POST-OPERATIVE OPTIONS

Blood conservation is an essential aspect of total hip arthroplasty (THA). As recently as 10 years ago, it was standard practice across North America for patients to undergo pre-operative autologous blood donation (PAD) prior to an elective TJA. Though the cost of PAD is about the same as allogenic blood transfusion, it has fallen out of favor due to mixed results. Instead, most surgeons have implemented a practice of obtaining pre-operative hemoglobin levels. If anemia is diagnosed, the patient should be worked up for the underlying cause. In cases of pre-operative anemia where a specific deficiency cannot be elucidated, consideration can be given to the use of erythropoietin (EPO). The routine use of tranexamic acid (TXA) has become the standard of care at most institutions since it is safe, inexpensive, easy to administer, and very effective at minimizing peri-operative blood transfusion. Intravenous TXA can be administered effectively in a variety of different ways and a number of different protocols are described. The popularised Mayo Clinic protocol is to administer TXA once prior to incision (1g IV in 50mL of normal saline) and once during wound closure. Acute normovolemic hemodilution is a technique utilised just before or after the induction of anesthesia in which whole blood is removed while keeping the patient normovolemic with acellular fluids (i.e. crystalloids or colloids). This technique is rarely used. Hypotensive anesthesia is a technique utilised to keep mean arterial pressures (MAP) at a level around 50mm Hg. It appears to be most effective with the use of epidural anesthesia. Certain patients may not be good candidates for hypotensive anesthesia (high cardiac risk factors), but it can be an effective corollary to other intra-operative measures. Historically, many surgeons practiced reflexive transfusion protocols rather than treating patients on an individual basis. Current practice has adopted a more pragmatic approach to transfusion. Specifically, patients are assessed for signs of anemia and are often allowed to drift well below 8g/dL as long as they remain asymptomatic and have a suitable cardiac risk.
Additive Manufacturing of Functionally Graded Objects: A Review

Functionally graded materials (FGM) have recently attracted a lot of research attention in the wake of the recent prominence of additive manufacturing (AM) technology. The continuously varying spatial composition profile of two or more materials affords FGM object to simultaneously possess ideal properties of multiple different materials. Additionally, emerging technologies in AM domain enables one to make complex shapes with customized multifunctional material properties in an additive fashion, where laying down successive layers of material creates an object. In this paper, we focus on providing an overview of research at the intersection of AM techniques and FGM objects. We specifically discuss the FGM modeling representation schemes and outline a classification system to classify existing FGM representation methods. We also highlight the key aspects such as the part orientation, slicing, and path planning processes that are essential for fabricating a quality FGM object through the use of multi-material AM techniques.Copyright © 2016 by ASME
A Compact Operational Amplifier with Load-Insensitive Stability Compensation for High-Precision Transducer Interface

High-resolution electronic interface circuits for transducers with nonlinear capacitive impedance need an operational amplifier, which is stable for a wide range of load capacitance. Such operational amplifier in a conventional design requires a large area for compensation capacitors, increasing costs and limiting applications. In order to address this problem, we present a gain-boosted two-stage operational amplifier, whose frequency response compensation capacitor size is insensitive to the load capacitance and also orders of magnitude smaller compared to the conventional Miller-compensation capacitor that often dominates chip area. By exploiting pole-zero cancellation between a gain-boosting stage and the main amplifier stage, the compensation capacitor of the proposed operational amplifier becomes less dependent of load capacitance, so that it can also operate with a wide range of load capacitance. A prototype operational amplifier designed in 0.13- μ m complementary metal–oxide–semiconductor (CMOS) with a 400-fF compensation capacitor occupies 900- μ m 2 chip area and achieves 0.022–2.78-MHz unity gain bandwidth and over 65 ∘ phase margin with a load capacitance of 0.1–15 nF. The prototype amplifier consumes 7.6 μ W from a single 1.0-V supply. For a given compensation capacitor size and a chip area, the prototype design demonstrates the best reported performance trade-off on unity gain bandwidth, maximum stable load capacitance, and power consumption.
Improved Ribosome-Footprint and mRNA Measurements Provide Insights into Dynamics and Regulation of Yeast Translation

Summary Ribosome-footprint profiling provides genome-wide snapshots of translation, but technical challenges can confound its analysis. Here, we use improved methods to obtain ribosome-footprint profiles and mRNA abundances that more faithfully reflect gene expression in Saccharomyces cerevisiae . Our results support proposals that both the beginning of coding regions and codons matching rare tRNAs are more slowly translated. They also indicate that emergent polypeptides with as few as three basic residues within a ten-residue window tend to slow translation. With the improved mRNA measurements, the variation attributable to translational control in exponentially growing yeast was less than previously reported, and most of this variation could be predicted with a simple model that considered mRNA abundance, upstream open reading frames, cap-proximal structure and nucleotide composition, and lengths of the coding and 5′ UTRs. Collectively, our results provide a framework for executing and interpreting ribosome-profiling studies and reveal key features of translational control in yeast.
Turning Privacy Inside Out

The problem of theorizing privacy moves on two levels, the first consisting of an inadequate conceptual vocabulary and the second consisting of an inadequate institutional grammar. Privacy rights are supposed to protect individual subjects, and so conventional ways of understanding privacy are subject-centered, but subject-centered approaches to theorizing privacy also wrestle with deeply embedded contradictions. And privacy’s most enduring institutional failure modes flow from its insistence on placing the individual and individualized control at the center. Strategies for rescuing privacy from irrelevance involve inverting both established ways of talking about privacy rights and established conventions for designing institutions to protect them. In terms of theory, turning privacy inside out entails focusing on the conditions that are needed to produce sufficiently private and privacy-valuing subjects. Institutionally, turning privacy inside out entails focusing on the design, production, and operational practices most likely to instantiate and preserve those conditions.
Functional Relevance of Improbable Antibody Mutations for HIV Broadly Neutralizing Antibody Development

Summary HIV-1 broadly neutralizing antibodies (bnAbs) require high levels of activation-induced cytidine deaminase (AID)-catalyzed somatic mutations for optimal neutralization potency. Probable mutations occur at sites of frequent AID activity, while improbable mutations occur where AID activity is infrequent. One bottleneck for induction of bnAbs is the evolution of viral envelopes (Envs) that can select bnAb B cell receptors (BCR) with improbable mutations. Here we define the probability of bnAb mutations and demonstrate the functional significance of key improbable mutations in three bnAb B cell lineages. We show that bnAbs are enriched for improbable mutations, which implies that their elicitation will be critical for successful vaccine induction of potent bnAb B cell lineages. We discuss a mutation-guided vaccine strategy for identification of Envs that can select B cells with BCRs that have key improbable mutations required for bnAb development.
The Pitfalls of Provisioning Exascale Networks: A Trace Replay Analysis for Understanding Communication Performance

Data movement is considered the main performance concern for exascale, including both on-node memory and off-node network communication. Indeed, many application traces show significant time spent in MPI calls, potentially indicating that faster networks must be provisioned for scalability. However, equating MPI times with network communication delays ignores synchronization delays and software overheads independent of network hardware. Using point-to-point protocol details, we explore the decomposition of MPI time into communication, synchronization and software stack components using architecture simulation. Detailed validation using Bayesian inference is used to identify the sensitivity of performance to specific latency/bandwidth parameters for different network protocols and to quantify associated uncertainties. The inference combined with trace replay shows that synchronization and MPI software stack overhead are at least as important as the network itself in determining time spent in communication routines.