cssi/SciSciGPT-SciSciNet huggingface dataset:
Spontaneous chromosome loss in Saccharomyces cerevisiae is suppressed by DNA damage checkpoint functions

Genomic instability is one of the hallmarks of cancer cells and is often the causative factor in revealing recessive gene mutations that progress cells along the pathway to unregulated growth. Genomic instability can take many forms, including aneuploidy and changes in chromosome structure. Chromosome loss, loss and reduplication, and deletions are the majority events that result in loss of heterozygosity (LOH). Defective DNA replication, repair, and recombination can significantly increase the frequency of spontaneous genomic instability. Recently, DNA damage checkpoint functions that operate during the S-phase checkpoint have been shown to suppress spontaneous chromosome rearrangements in haploid yeast strains. To further study the role of DNA damage checkpoint functions in genomic stability, we have determined chromosome loss in DNA damage checkpoint-deficient yeast strains. We have found that the DNA damage checkpoints are essential for preserving the normal chromosome number and act synergistically with homologous recombination functions to ensure that chromosomes are segregated correctly to daughter cells. Failure of either of these processes increases LOH events. However, loss of the G2/M checkpoint does not result in an increase in chromosome loss, suggesting that it is the various S-phase DNA damage checkpoints that suppress chromosome loss. The mec1 checkpoint function mutant, defective in the yeast ATR homolog, results in increased recombination through a process that is distinct from that operative in wild-type cells.
Software knows best: portable parallelism requires standardized measurements of transparent hardware

The hardware trend of the last 15 years of dynamically trying to improve performance with little software visibility is not only irrelevant today, its counterproductive; adaptivity must be at the software level if parallel software is going to be portable, fast, and energy-efficient. A portable parallel program is an oxymoron today; there is no reason to be parallel if it's slow, and parallel can't be fast if it's portable. Hence, portable parallel programs of the future must be able to understand and measure /any/ computer on which it runs so that it can adapt effectively, which suggests that hardware measurement should be standardized and processor performance and energy consumption should become transparent.In addition to software-controlled adaptivity for execution efficiency by using techniques like autotuning and dynamic scheduling, modern software environments adapt to improve /programmer/ efficiency [1]. Classic examples include dynamic linking, dynamic memory allocation, garbage collection, interpreters, just-in-time compilers, and debugger-support. Examples that are more recent are selective embedded just in time specialization (SEJITS) [2] for highly productive languages like Python and Ruby. Thus, the future of programming is likely to involve program generators at many levels of the hierarchy tailoring the application to the machine. These productivity advances via adaptivity should be reflected in modern benchmarks: virtually no one writes the statically linked, highest-level-optimized C programs that are the foundation of most benchmark suites.The dream is to improve productivity without sacrificing too much performance. Indeed, how often have you heard the claim that a new productive environment is now "almost as fast as C" or "almost as fast as Java?" The implication of the necessary tie between productivity and performance in the manycore era is that these modern environments must be able to utilize manycore well, or the gap between highly efficient code and highly productive code will grow with the number of cores.For industry's bet on manycore to win, therefore, both very high level and very low level programming environments will need to be able to understand and measure their underlying hardware and adapt their execution so as to be portable, relatively fast, and energy-efficient.Hence, we argue that a standard of accurate hardware operation trackers (SHOT) would have a huge positive impact on making parallel software portable with good performance and energy efficiency, similar to the impact of the IEEE-754 standard had on portability of numerical software. In particular, we believe SHOT will lead to much larger improvements in portability, performance, energy efficiency of parallel codes than recent architectural fads like opportunistic "turbo modes," transactional memory, or reconfigurable computing.
Separating Mycoplasma gallisepticum Field Strains from Nonpathogenic Avian Mycoplasmas

Mycoplasma gallisepticum (MG) has repeatedly emerged as a serious problem in U.S. broiler, layer, and turkey industries. Tracing the source of an outbreak is essential if MG control is to be accomplished. Amplified fragment length polymorphism (AFLP), random amplification of polymorphic DNA (RAPD), and restriction fragment length polymorphism (RFLP) are valuable tools used to study MG epidemiology, allowing diagnosticians to determine the source of MG infections. In some past outbreaks, AFLP, RAPD, and RFLP fingerprinting, which require pure MG cultures, were not successful because of contaminating nonpathogenic mycoplasmas from field samples. The objective of this research was to develop a method to separate rapidly growing nonpathogenic avian mycoplasma species from slower-growing MG field strains. Mixtures of MG and three separate nonpathogenic avian mycoplasmas were inoculated onto chick embryo fibroblasts cells (CEF) allowing MG to penetrate the CEF cells. Later, gentamicin sulphate was added to the culture, eliminating the nonpathogenic mycoplasmas and allowing MG to be isolated in pure culture. Mixtures of Mycoplasma synoviae (MS) and MG could not be separated in this assay. However, removal of nicotinamide adenine dinucleotide and cysteine hydrochloride during serial passage in Frey broth medium successfully eliminated growth of MS.
A case report of ankylosing spondylitis treated by acupuncture

The following is a case study of a patient with Ankylosing Spondylitis (AS). She presented to our clinic seeking pain relief/control after having exhausted all pharmaceutical options. A regimen of Acupuncture treatment plan was not only successful in relieving her pain but was helpful in preventing future episodic relapses. This patient is no longer taking pain medications prescribed beforehand.
DYNAMICS OF HYPOID GEAR TRANSMISSION WITH NON-LINEAR TIME-VARYING MESH

A new generalized 14 degrees -of-freedom dynamic model with coupled translation-rotation effect is developed for simulating the nonlinear vibratory response of hypoid geared rotor systems. The model incorporates the load-dependant time-varying mesh characteristic vectors due to tooth load sharing and profile modifications, backlash non-linearity, and off line-of-action friction forces. Based on the 3dimensional tooth contact analysis results, the quasi-static mesh characteristics that describe the translation-rotation and rotationrotation force couplings are obtained for use in the dynamic formulation. The three-dimensional representations of the mesh vectors, normal and friction forces, and moments generated at the mesh interface are also included in the proposed study. Tooth separation and the occurrence of jump phenomenon observed in the predicted frequency response functions are analyzed.
Viscoelasticity and Tearing Energy of Fluorinated Hydrocarbon Elastomers

Etude de 3 sortes de Viton (copolymer de fluorure de vinylidene et d'hexafluoro propylene) diversement reticules
The microearthquake activity of Mt. Rainier, Washington

Abstract A network of five high-gain portable seismographs was operated around Mt. Rainier, Washington, from July 13 to August 11 1968, to study microearthquakes associated with this volcano. Approximately 345 microearthquakes were detected during the 30-day recording interval. Of these, hypocenters and magnitudes were determined for 65 selected events. The microearthquakes were concentrated in two general regions: (1) about 80 per cent were in a roughly concentric pattern around the western side of the volcano at depths ranging from 0.5 to 15 km, and (2) about 8 per cent were beneath the summit crater at depths ranging from 0.2 to 20 km. About 75 per cent of the microearthquakes were at depths less than 5 km. These two groups of microearthquakes can be further defined genetically, as the first may be teatonic earthquakes not related directly to volcanic processes and the second appear to be earthquakes possibly of volcanic origin. The cumulative frequency versus magnitude relation for the tectionic microearthquakes is log ⁡ N = 5.2 − 0.82 ( 8 − M ) .
Immunized Mice Challenged with Herpes Simplex Virus by the Intranasal Route Show Protection Against Latent Infection

Chez la souris la vaccination par la glycoproteine du virus de la vaccine par voie caudale ou nasale a entraine l'apparition d'anticorps neutralisants et d'une protection contre la provocation letale et latente. Malgre le fait que les animaux avait ete vaccines par voie nasale des anticorps principalement responsables de la protection au siege de la replication locale du virus peuvent avoir ete des anticorps Igb du serum plutot que des anticorps IgA
"Criss-crossed" dinucleating behavior of an N4 Schiff base ligand: formation of a μ-OH,μ-O2 dicobalt(III) core via O2 activation.

We report the synthesis and structural characterization of a dicobalt(III) complex with a μ-OH,μ-O2 core, namely μ-OH,μ-O2-[Co(enN4)]2(X)3 [1(ClO4)3 and 1(BF4)3]. The dinuclear core is cross-linked by two N4 Schiff base ligands that span each cobalt center. The formally CoIII–CoIII dimer is formed spontaneously upon exposure of the mononuclear Co(II) complex to air and exhibits a ν(O–O) value at 882 cm–1 that shifts to 833 cm–1 upon substitution with 18O2. The CV of 1(BF4)3 exhibits a reversible {CoIII–CoIII}↔{CoIII–CoIV} redox process, and we have investigated the oxidized {CoIII–CoIV} species by EPR spectroscopy (g = 2.02, 2.06; S = 1/2 signal) and DFT calculations.
Party, Region and the Dimensions of Conflict in the House of Representatives, 1949–1954

Recent publications indicate a continuing interest among political scientists in both the aggregating of discrete acts of legislative behavior into underlying dimensions and the empirical specification of voting blocs. The latter interest is served by the former, as aggregation often producs sets of dimensions useful for descriptive purposes, as well as aiding other types of analysis. Recent studies include MacRae's work on the House of Representatives using various forms of scaling, Alker's paper on voting patterns in the sixteenth General Assembly of the United Nations using factor analysis, and Grumm's work on the Kansas legislature using another form of factor analysis (Q-technique).1 As these papers have described in some detail, the technique of factor analysis is particularly useful in producing empirical dimensions which are unitary, stable, exhaustive and parsimonious.2 This paper presents three such analyses-one each for the 81st, 82nd and 83rd
Perceptions and Perceived Impact of Graphic Cigarette Health Warning Labels on Smoking Behavior Among U.S. Young Adults

INTRODUCTION In 2011, the Food and Drug Administration published a final rule requiring cigarette packages and advertisements to include graphic health warning labels (HWLs) with new warning statements. Implementation of this rule has been stalled by legal challenge. This study assessed correlates of smoking-related intentions related to graphic HWLs among current cigarette smokers and nonsmokers in a national sample of U.S. young adults aged 18-34. METHODS Data were collected from 4,236 participants aged 18-34 using an online panel in January 2012 for the Legacy Young Adult Cohort Study. Analyses were weighted to provide nationally representative estimates. Our main outcome was assessed with a single item: "Do you think that new warning labels with graphic pictures would make you think about not smoking?" RESULTS Twenty-two percent of the young adults were current cigarette smokers. Fifty-three percent endorsed that new graphic HWLs would make them think about not smoking (40% among current smokers compared with 56% among nonsmokers). Among nonsmokers, those aged 18-24, females, Hispanics, and those who were aware of graphic cigarette HWLs were more likely to report intention to not smoke related to graphic HWLs. Among current smokers, intending to quit within the next 6 months was correlated with intention resulting from graphic HWLs. Hispanic ethnicity and intention to quit within 30 days were strong correlates of intention in light, nondaily, and self-identified social/occasional smokers. CONCLUSIONS This study supports previous findings that graphic HWLs play an important role in preventing smoking, in addition to encouraging cessation in young adults.
Finite Element Analysis in Unbounded Two-Dimensional Regions Using Schwarz-Christoffel Transformation:

The finite element method is one of the most widely used methods available to educators to compute electric potential fields in two dimensional geometries that can be described by partial differential equations such as Laplace's equation. However, it can not easily be applied to unbounded regions. This paper describes a hybrid method that relies on conformal transformations, including the Schwarz-Christoffel (S-C) transformation (without having to compute the transformation functions) to map the original boundaries, including those at infinity, to a bounded region and only then applies the finite element method. Testing this approach by means of an example for which an exact solution is obtainable, the hybrid method is applied to determine the electrical potential at a specific point in the field of an integrated circuit (IC) microstrip line. The results are in agreement with analytically derived results and can be used in graduate research as well as by professional engineers.
EFFECT OF LEFT VENTRICULAR SYSTOLIC DYSFUNCTION ON WARFARIN DOSE

Patients who take warfarin for anticoagulation remain therapeutic only around half the time. Many indications for anticoagulation, including atrial fibrillation, occur commonly in patients with heart failure (HF) with reduced ejection fraction (HFrEF). HFrEF leads to reduced perfusion as well as
Long-range forces affecting equilibrium inertial focusing behavior in straight high aspect ratio microfluidic channels

The controlled and directed focusing of particles within flowing fluids is a problem of fundamental and technological significance. Microfluidic inertial focusing provides passive and precise lateral and longitudinal alignment of small particles without the need for external actuation or sheath fluid. The benefits of inertial focusing have quickly enabled the development of miniaturized flow cytometers, size-selective sorting devices, and other high-throughput particle screening tools. Straight channel inertial focusing device design requires knowledge of fluid properties and particle-channel size ratio. Equilibrium behavior of inertially focused particles has been extensively characterized and the constitutive phenomena described by scaling relationships for straight channels of square and rectangular cross section. In concentrated particle suspensions, however, long-range hydrodynamic repulsions give rise to complex particle ordering that, while interesting and potentially useful, can also dramatically diminish the technique’s effectiveness for high-throughput particle handling applications. We have empirically investigated particle focusing behavior within channels of increasing aspect ratio and have identified three scaling regimes that produce varying degrees of geometrical ordering between focused particles. To explore the limits of inertial particle focusing and identify the origins of these long-range interparticle forces, we have explored equilibrium focusing behavior as a function of channel geometry and particle concentration. Experimental results for highly concentrated particle solutions identify equilibrium thresholds for focusing that scale weakly with concentration and strongly with channel geometry. Balancing geometry mediated inertial forces with estimates for interparticle repulsive forces now provide a complete picture of pattern formation among concentrated inertially focused particles and enhance our understanding of the fundamental limits of inertial focusing for technological applications.
Application of Field Bus in the Wastewater Treatment Plant

With the continuous improvement of the degree of automation,the use of intelligent instrumentation and field bus become more and more widely in the wastewater treatment plant control system.But a variety of instrument communication protocol selection and choice of field bus are followed.Equipment manufacturers may support different communication protocols.So,in the control system design of wastewater treatment plant,chooses the Profibus-DP as the main field bus,and converts other protocol to Profibus-DP protocol.That makes the system's field bus unify and improves the reliability of the system,and has promotional value in network design.
Influences of Heat Treatment Atmosphere on Interface Reaction of ZrO_2 Active Diffusion Barrier and NiCrAl Coating

ZrO2ceramic film and NiCrAl coating were respectively deposited on DD5Ni-based supper alloy by electron beam physical vapor deposition(EB-PVD)to investigate the formation of ZrO2 active diffusion barrier.The specimens were heat treated under 700,800 and 900℃for 5hin both vacuum and atmospheric conditions.By comparing the cross section morphology,the thickness of the diffusion-reaction zones and the element nearby the interface of ZrO2/NiCrAl,the influences of the interface reaction between the ZrO2 active diffusion barrier and the NiCrAl coating under different heat treatment conditions were investigated.The results indicate that the vacuum condition is more conducive to the interfacial reaction,and after900 ℃/5hvacuum-treated,a continued and dense Al2O3 diffusion barrier forms on the interface of ZrO2/NiCrAl.However,a portion of Al element in NiCrAl coating is diffused to the surface to form the oxidation scale under heat treatment in the atmospheric condition,which would damage the interface reaction between ZrO2 and NiCrAl coatings.
Development and Solution of Sand Inflow Erosion Model for Cold Heavy Oil Production

The developed sand inflow erosion model for cold heavy oil production is based on the mass conservation law and Darcy's law, considering the effect of fluid flowing on sand inflow/production, and the solution in uncompressible condition of single phase is obtained. The result shows that continuous sand inflow greatly improves the porosity near the well and the performance of fluid flowing, thus increasing the heavy oil production with tendency of sand inflow increasing drastically in the early period, then declining, and finally reaching stability. Such a feature is accordant with the field data. It is demonstrated that the valid model of one dimension can be applied to guide the experiment of sand inflow and cold production, and make validation as well. Hence this model is of bright future for application to the sand inflow erosion model's study under radial flow, two-phase flow, and coupling with rock matrix plastic deformation.
On the System of Government Affairs Office in the Tang Dynasty

WT5”BZ]The system of government affairs office started in the early years of the Tang dynasty.The system worked like this:governors of Shangshu province,Zhongshu province and Menxia province met regularly at a fixed time and in a fixed place to discuss about state affairs.The emperor made the final decision.The system was “seperation of the three powers” with Chinese characteristics in the feudal society.Discussing about state affairs in the government affairs office in Menxia province was the normal state.Discussing about state affairs in Zhongshu province indicated that the system was deteriorating.Transferring the government affairs office to Zhongshu and Menxia province marked the collapse of the system.
Network Relaxations and Lower Bounds for Multiple Choice Problems

AbstractThis paper provides new network relaxations and penalty calculations for 0-1 integer programs with multiple choice constraints. The multiple choice problem, which may be viewed as a 0-1 problem with generalized upper bounding (GUB) restrictions, arises in a variety of applications involving scheduling, location and assignment.The value of network relaxations lies in their speed of solution (roughly two orders of magnitude faster than LP relaxations) and in their numerical accuracy. Nevertheless, LPrelaxations are more restrictive than network relaxations; that is, they provide tighterlower bounds. Hence the practical superiority of network relaxations appears to be chieflyfor ip problems with no more than six or seven non-zeroes per column of the coefficientmatrix. Consequently, it is important to identify new network relaxations with benefits forspecial structures andto derive stronger lower bounds for network relaxations generally, thus extending the range of problems network-based algorithms ca...
Mapping Metrics for Subject-Object Coordinated Field Recognition and Representation

A sample microcomputer software program, using concise IBM BASICA LOGO language, provides a formula and skeleton for micro-networking and mapping the essential objects, a cumulative repository of advantageous learning experiences and knowledge. These objects are pre-definable through citation analysis within a particular subject field. These objects become progressive and inheritable through a hierarchical chaining mechanism. A machine readable map is thus generated. It can be used as an independent research indicator for mapping a particular subject field. It can also be linked to related BASIC programs or shelled over to support other software packages. A micro-network within a subject field is economically established on a personal computer station. It can also be effectively expanded to perform as a language translator to coordinate the bilingual and multi-cultural arena.
Curriculum of Embedded System for Software Colleges

Embedded system has already been applied in numerous fields, such as the industry control system, information appliances, communication equipments, medical instruments, intelligence instruments and so on. As processors become more powerful, electronic products become more complex. Embedded system designers are able to include design features traditionally associated with personal computer (PC) including graphical user interfaces, TCP/IP networking, and database management. For introducing knowledge of embedded system to student of master of software engineering (MSE), the Software College at Tsinghua university and Beihang university had an opportunity to add technical electives for embedded system, the author received approval to teach embedded system design course. This paper describes the development and implementation of that course toward the goal of teaching students the hardware considerations, software considerations, and design processes involved in embedded system design. In the end, the teaching effect of course for embedded system design is analyzed.
Personal and Professional Well-Being of Surgical Residents in New England

Background Although there is increasing literature about burnout and attrition among surgeons, little is known about personal and professional well-being of surgical trainees. Study Design General surgery residents from the 6 New England states participated in a cross-sectional, qualitative, self-reported survey to assess the domains of personal health maintenance, personal finance, work environment, and fatigue management as they relate to surgical training. Results All surgical residency programs in the New England region were invited to participate. Of these 19 programs, 10 elected to participate in the study. Three hundred and sixty-three total trainees were contacted with requests to participate, and 166 completed responses to the survey, resulting in a response rate of 44.9%. Ninety percent of respondents identified their programs as "university or academic." Substantial cohorts reported that during training they lacked basic healthcare maintenance visits (54%) and had undesired weight gain (44%). Although most found their stipends adequate, three-quarters worried about their finances (75%) and reported substantial educational debt (45%). Most residents enjoyed coming to work; however, the vast majority reported that work-related stress is moderate to extreme (92%). Most also reported that work-related stress negatively affects their overall well-being (72%). The mean Epworth Sleepiness Scale score among respondents was 14, consistent with moderate excessive daytime sleepiness. Conclusions Surgical trainee well-being is critical to optimal patient care, career development, and burnout reduction. Surgical residents attend to their own preventive health maintenance, finances, sleep, and stress reduction with variable success. Residency programs should make modest programmatic accommodations to allow trainees to tend to various aspects of their personal well-being.
The ontological and epistemological superiority of hylomorphism

Materialism—the view that all of reality is wholly determined by the very, very small—and extreme nominalism—the view that properties, kinds, and qualities do not really exist—have been the dominant view in analytic philosophy for the last 100 years or so. Both views, however, have failed to provide adequate accounts for the possibility of intentionality and of knowledge. We must therefore look to alternatives. One well-tested alternative, the hylomorphism of Aristotle and the medieval scholastics, was rejected without being refuted and so deserves further examination. I will argue that Aristotelian hylomorphic provides a markedly superior account of knowledge, cognitive normativity, and intentionality.
Tumorigenesis in Mice with an SV40 T Antigen Transgene Driven by the Immunoglobulin γ1 Heavy Chain Germline Promoter

The immunoglobulin heavy chain switch is a genetic recombination whereby a V(D)J region is rearranged from association with the Cµ gene to association with a downstream Cγ, Ce, or Cα gene [1,2). The recombination event occurs in switch (S) regions found upstream of each CH gene except Cδ. Switch recombination is preceded by a change in the “accessibility” of the switch region DNA, as indicated by the induction of transcription of the CH locus prior to switch recombination [1–4]. Both induction of germline transcripts and switch recombination of any CH locus are specifically regulated by cytokines.
Localized hydrogen peroxide metabolism and cardiovascular signal transduction

The molecular events underlying the transition from “physiological” to “pathological” reactive oxygen species (ROS) in the vascular endothelium are poorly understood. We constructed differentially-targeted HyPer2 biosensors for H2O2 to identify the intracellular organelles and pathways responsible for dynamic regulation of endothelial H2O2 metabolism. We discovered that laminar (physiological) shear stress robustly increases H2O2 in the endothelial cell nucleus much more than in the cytosol. By contrast, oscillatory (pathological) shear increases H2O2 in the cytosol significantly more than in the nucleus. We generated H2O2 within specific subcellular locales in cultured endothelial cells using recombinant constructs expressing a D-amino acid oxidase (DAAO) that robustly generates H2O2 upon the addition of D-alanine to the cells. Using a series of differentially targeted DAAO constructs, we discovered H2O2 generation in distinct subcellular compartments differentially modulates endothelial transcription. Generation of H2O2 by DAAO in the endothelial cell nucleus enhanced transcription of Nrf2-modulated genes, whereas generation of H2O2 by DAAO targeted to the cytosol activated NF-kB-regulated genes. These findings have important implications for our understanding of flow-responsive genes in the normal blood vessel as well as in disease states associated with disordered blood flow and oxidative stress.
Prevalence, correlates, and impact of coronary calcification on adverse events following PCI with newer-generation DES: Findings from a large multiethnic registry

Objectives We sought to determine the prevalence, predictors, and clinical impact of target lesion calcification in patients undergoing percutaneous coronary intervention (PCI) with newer generation drug-eluting stents (DES) and devices. Background Coronary calcification is independently associated with adverse outcomes following PCI. While newer DES and contemporary devices are considered safer and more efficacious, their influence on outcomes following PCI of heavily calcified lesions is unknown. Methods We performed a retrospective analysis of a large, multiethnic cohort of patients undergoing PCI with new generation DES at an academic center between 2009 and 2013. Coronary calcification was qualitatively assessed as none/mild, moderate, or severe. Independent demographic, clinical, and anatomic predictors of moderate/severe calcification were identified using logistic regression. Associations between coronary calcification and 1-year MACE (death, myocardial infarction, or target vessel revascularization) were examined using Cox modeling. Results Compared to patients with none/mild (n = 10,180; 82.0%), those with moderate (n = 1,271; 10.0%) or severe (n = 994; 8.0%) calcification were older, more often Caucasian, had more complex target lesions, and worse renal function. The strongest demographic, clinical, and anatomic correlates of moderate/severe calcification were age, Caucasian race, renal dysfunction, lesion length, and left main location. Unadjusted MACE rates among those with none/mild, moderate, and severe calcification were 8.3, 14.6, and 17.8%, respectively (P < 0.001). After multivariable adjustment, the hazard ratio (95% CI) for MACE associated with moderate or severe coronary calcification was 1.63. Conclusions Target lesion calcification remains independently associated with adverse outcomes in patients treated with newer generation DES and modern devices.
Understanding and controlling wafer surface contamination at wafer level chip scale package — Wiljelm Carl K. Olalia

In a semiconductor manufacturing processes such as Wafer Level Chip Scale Package, yield is one of the Key Performance Indicator. Yield is also an indicator for Quality, Productivity and OEE. If the yield is below the limits or cut-off, it said to be that there is a sign of poor quality since the process is rejecting Wafer or Dice affected by different defects either by Electrical or by Visual Mechanical. One of the ON's Key Customer Expectation Requirements in terms of Product Quality is “Zero Defects”. There is an equivalent cost for each poor quality computed by number of dice or ppm. In terms of Productivity, Low Yield product is being hold at the process before moving the lot to next process or shipping out. The additional time required to Engineer on analyzing the problem resulted to longer cycle time or queuing. ON's Key Customer Expectation Requirements in terms of Service is 90–100% On Time Delivery. Lastly, for the OEE, definitely low yield will directly affect the overall equipment efficiency since one of the parameter when computing the OEE is the Good Parts from the product on top of the Ideal Cycle Time and Earned Hours from the Master Plan. To conclude, improving the yield will also improve the Quality, Productivity and Cycle Time.
Mutagen Screening with Virulent Bacteriophages

Virus systems, and particularly those employing the T-even bacteriophages, the single-stranded DNA bacteriophages, and the temperate bacteriophage λ, have occupied the center of the molecular biologist’s arena for up to three decades. The reasons for the popularity of virus systems are as relevant now as they were in the 1930s. Viruses often excel in those properties which make microorganisms in general highly useful for genetic studies. They are easy to grow. They exhibit extremely short generation times. (The bacteriophage T4 growth cycle, encompassing about 30 min at 37°C and resulting in the release of several hundred progeny particles, corresponds to an average doubling time of about 3 to 4 min.) Genome storage is extremely simple. Virus stocks are stable for many years in the refrigerator and do not accumulate many spontaneous mutations (Drake, 1966). Extremely large populations (for instance, 1011 to 1014 particles) are easily obtained, and a variety of techniques have been developed for selecting rare particles representative of events such as mutation. The relative chemical simplicity of bacteriophages, together with certain chemically unique aspects of their reproduction, has made possible a more detailed dissection of their molecular genetics than has been achieved even in the equally well-studied bacterium Escherichia coli. The formal genetics of several virus systems has been developed to a highly detailed and sophisticated level, making possible numerous genetic manipulations which render the analysis of processes such as mutation highly profitable. Finally, the pursuit of bacteriophage genetics, including even many aspects of their molecular genetics, is relatively inexpensive, particularly in comparison with metazoan systems.
A Microcomputer Based Park Resources Management System for Glacier National Park

The primary objective of this project is to assess the computing needs of the Glacier National Park and to make recommendations with respect to the management of park resources. As originally proposed, one of the principal objectives was to consult with the park service and to suggest alternatives for hardware configurations that would meet the ever increasing information management requirements of Glacier National Park. Before the initial meeting between the principal investigator and park service personnel, however, a Datapoint minicomputer was selected by the regional office in Denver for use by Glacier as well as other parks within the area. Thus, the objectives to be attained by this and subsequent reports will deal primarily with the uses to which the newly acquired hardware can be put as well as suggesting methods of operation and additional hardware which would enhance information processing at Glacier National Park.
Techniques for Preemptive Analgesia in Gynecologic Surgery

ABSTRACT Study Objective To provide surgeons with techniques for preemptive analgesia during minimally invasive gynecologic surgery. Postoperative pain management is an important component of patient care after gynecologic surgery. There have been numerous advances in pain management, including studies that show that preoperative administration of analgesics decreases postoperative pain scores and narcotic medication requirements 1 , 2 , 3 . However, there is limited information on the techniques for preemptive analgesia 4 , 5 . Design An instructional video showing a variety of preemptive analgesia techniques and the corresponding neuroanatomy (Canadian Task Force classification III). Mayo Clinic Institutional Review Board approval was not required for this video article. Setting Academic Medical Center Interventions Relevant abdominopelvic neuroanatomy is reviewed. This is followed by a demonstration of the preemptive analgesia techniques based on neuroanatomy principles. Conclusion Techniques for preemptive analgesia are simple and effective. These tools can be used for patients undergoing gynecologic surgeries via a vaginal or abdominal approach and can help optimize postoperative pain and narcotic usage.
On the use of group performance and rights for environmental protection and resource management.

Environmental and natural resource (ENR) policies that focus on group outcomes are common but have received relatively less attention from economists than policies based on individual behavior. Existing research tends to focus on particular contexts, such as water or air quality, fisheries, or land use. This paper discusses unifying themes of group performance policies, along with their advantages and disadvantages. We discuss a range of specific policy instruments, including group-based taxes, subsidies, and fixed penalties. We show how, in principle, group-based policies can be designed to achieve efficient provision of group-level environmental performance; however, in some cases, group policies can lead to suboptimal outcomes. We discuss the incentives for collaboration that can arise when regulators impose group performance policies, and the role that it can play in promoting efficient outcomes. We argue that the success of group-based policies will depend both on how the policy is designed (i.e., the external rewards and penalties) and on how the group operates. This implies potential complementarities between “top-down” regulatory interventions based on group performance and “bottom-up” within-group incentives for self-governance. Our discussion suggests that group performance policies should play a more prominent role in the suite of policy instruments considered by scholars and policymakers concerned with ENR management.
Majority of female bariatric patients retain an obese identity 18–30 months after surgery

When bariatric surgery is performed, a successful outcome is usually described as % total weight lost (EWL) or a change in BMI. These definitions fail to address the importance of post-operative psychosocial adjustment. Previous research has alluded to a ‘mind–body lag’ where the patient’s experienced body feels larger than their physically smaller post-operative body, perhaps as a result of amygdalae conditioning. The purpose of this study is to further investigate this psychological issue and assess its relationship to health locus of control, alexithymia, health quality of life and weight regain in bariatric surgery patients. Forty female bariatric surgery patients between 18 and 30 months post-op completed demographic data, survey instruments and anthropometric testing. Their evolving self-view, health locus of control, tendency toward alexithymic thought, and health quality of life were measured to identify significant relationships. Hermans’ Dialogical Self Theory was used to understand the conflicted self-view of the participants. The majority of participants retained an obese view of self despite weight loss. Those who retained an ‘I-obese’ viewpoint were significantly more likely to see external situations and powerful others as controlling their weight, have difficulty identifying their feelings and score significantly lower in vitality, social functioning and mental health. Despite losing weight, the majority of participants retained an obese view of self that was significantly associated with a lessened health quality of life. Use of the Evolving Self-View (ESV) exploratory tool may allow early identification of post-operative patients with a prolonged ‘I-obese’ self-view and provide an opportunity for intervention. Level III, cross-sectional case-control study.
DeepSolar: A Machine Learning Framework to Efficiently Construct a Solar Deployment Database in the United States

Summary We developed DeepSolar, a deep learning framework analyzing satellite imagery to identify the GPS locations and sizes of solar photovoltaic panels. Leveraging its high accuracy and scalability, we constructed a comprehensive high-fidelity solar deployment database for the contiguous US. We demonstrated its value by discovering that residential solar deployment density peaks at a population density of 1,000 capita/mile2, increases with annual household income asymptoting at ∼$150k, and has an inverse correlation with the Gini index representing income inequality. We uncovered a solar radiation threshold (4.5 kWh/m2/day) above which the solar deployment is "triggered." Furthermore, we built an accurate machine learning-based predictive model to estimate the solar deployment density at the census tract level. We offer the DeepSolar database as a publicly available resource for researchers, utilities, solar developers, and policymakers to further uncover solar deployment patterns, build comprehensive economic and behavioral models, and ultimately support the adoption and management of solar electricity.
Effects of measurement timing on subgroup identification using growth mixture modeling: An empirical application to alcohol use

Growth mixture modeling (GMM) identifies latent classes exhibiting distinct longitudinal patterns on an outcome. Subgroups identified by GMM may be artifactually influenced by measurement timing (e.g., timing of the initial assessment, length of the interval from the first to the last assessment, and total number of assessments) as well as the theoretically posited developmental patterns of the behavior. The current study investigated this possibility using alcohol data from the 1997 National Longitudinal Survey of Youth (n = 2686; 49.44% female; 71.84% White). Three assessment configurations were examined: all 12 waves, first 6 waves, and last 7 waves. Five subgroups were identified using all 12 waves: Normative (71.33%), Low-Increasing (8.45%), Low-Steady (8.97%), High-Slowly Decreasing (7.67%), and Extreme-Sharply Decreasing (3.57%). When comparing participants' subgroup membership for all 12 waves to the first six waves, 14% of the sample was differentially classified. When comparing all 12 waves to the last seven waves, 62% of the sample was differentially classified. Alterations in the timing of the initial assessment had a substantial impact on latent class estimation, underscoring the importance of selecting the developmental window a priori based on theory and empirical knowledge. The time-bounded nature of mixture modeling solutions (i.e., a selected developmental window within the course of a phenomenon) suggests that the latent subgroups should not be interpreted as representing subgroups that are present in the population. Future directions and strategies for testing alternative interpretations are presented. (PsycINFO Database Record (c) 2019 APA, all rights reserved).
Non–24-hour Sleep-Wake Rhythm Disorder

Non-24-hour sleep-wake rhythm disorder is a circadian rhythm sleep-wake disorder characterized by an inability to entrain to the 24-hour environment. Patients present with complaints of insomnia or hypersomnia, with progressive daily shifts of sleep-wake activity on actigraphy or sleep logs. Although first recognized in blind individuals without light perception, it also can be seen in individuals with intact vision. Treatment focuses on timed melatonin in blind individuals, whereas it is more complex in sighted individuals, using multiple time cues, such as light, melatonin, social interactions, feeding, and activity.
A Census of Cades Cove Through Gravestones

Gravestone data (1840–1939; socio-demographics and epitaphs) were transcribed as social variables to describe various dimensions of the Cades Cove community. This included the sex/gender composition of the community, gender roles and familial statuses, patriarchal dominance and gender inequality, age structures and age statuses, ethnicity implied by surname, family/kinship importance, aspects of community integration (vitality and permeability), social class, homogeneity, religion, and seasonal patterns of fertility and mortality. This illustrates and demonstrates the archival capacity of cemeteries. While there are many things cemeteries cannot disclose, there are a few things only cemeteries can disclose, and the exploitation of cemetery as data source must be adroit.
The Pathway to Academic Success: Scaling Up a Text-Based Analytical Writing Intervention for Latinos and English Learners in Secondary School.

This study reports findings from a multisite cluster randomized controlled trial designed to validate and scale up an existing successful professional development program that uses a cognitive strategies approach to text-based analytical writing. The Pathway to Academic Success Project worked with partner districts affiliated with 4 National Writing Project (NWP) sites in southern California. Informed by a wide body of research on the efficacy of strategy instruction to enhance students’ academic literacy, the intervention aimed to help secondary school students, particularly Latinos and mainstreamed English learners, to develop the academic writing skills called for in the rigorous Common Core State Standards for English Language Arts. Two hundred thirty teachers from partner districts affiliated with the NWP sites were stratified by school and grade and then randomly assigned to the treatment or control group. Treatment teachers participated in 46 hrs of training and learned how to apply cognitive strategies by using an on-demand writing assessment to help students understand, interpret, and write analytical essays about nonfiction texts. Multilevel models revealed significant effects on a holistic measure of an on-demand writing assessment (d = .32) as well as on 4 analytic attributes: content (d = .31), structure (d = .29), fluency (d = .27), and conventions (d = .32). Four dimensions of scaling up—spread, reform ownership, depth, and sustainability—are also discussed. (PsycInfo Database Record (c) 2020 APA, all rights reserved)
Polarization-Shift Keying Using Low-Coherence Sources

Polarization-shift keying offers multi-dimensional signaling for systems using low-coherence sources. Non-Gaussian noise distributions are found to enable low bit-error rates up to at least 10Gsym/s when broad source bandwidths are used.
Design, analysis and fabrication of thick co-cured wing structures

Abstract Over the past few decades advances in the design, materials, and manufacturing of thermoset composite materials have expanded rapidly. Nonetheless, aerospace structures have not yet adapted many of these technologies. This can be attributed to the risk adverse nature of the engineering community and associated regulatory agencies in this field. One of the technologies that has recently gained more traction in the composites field is the use of unitized co-cure structures. Driving this change is the potential for reducing part count, touch time and labor costs. Most of the work done to date focuses on thinner structures (~0.15 inch in thickness) resulting in a lack of understanding of the behavior of much thicker parts representing wing-like structures. This paper provides insight into the fabrication of a full-scale wing demo made from Cycom 5320–1. The design, analysis and fabrication aspects are discussed and presented. It was shown that utilizing an outer mold line (OML) tooling approach with silicon mandrels provided a final product that achieves the set engineering tolerances. Nondestructive inspection showed no defects or anomalies in the part using the proposed fabrication approach. In addition, a brief discussion on the part warpage was presented and concluded that the amount of warpage detected in thick co-cured structures is less than that observed in co-bonded and secondary bonded parts.