cssi/SciSciGPT-SciSciNet huggingface dataset:
The response of fibrous composites to impact loading

The response of advanced composites to low-velocity projectile loading was investigated. The impact failure mechanisms of composites containing various fibers with different strength and ductility were studied by a combination of static indentation testing, instrumented falling dart impact testing, acoustic emission monitoring, and scanning electron microscopy (SEM). The composites containing fibers with both high strength and high ductility (eg., polyethylene (PE) fibers) demonstrate a superior impact resistance as compared to those containing fibers with high strength (eg., graphite fibers) or high ductility (eg., nylon fibers) but not both. Upon impact loading, the composites containing PE fibers usually exhibited a great degree of plastic deformation and some level of delamination. These mechanisms acted to dissipate a significant amount of strain energy prior to the penetration phase of the impact process. No through penetration was observed in all the samples containing more than three layers of PE fabric except when loaded at relatively high rates and low temperatures. Although certain levels of delamination also took place in other composite systems, very little plastic deformation occurred, allowing ready penetration of the projectile. The stacking sequences in the hybrid laminates studied were found to play a critical role in triggering or inhibiting the processes of plastic deformation and delamination and, therefore, controlling their energy absorption capability. The penetration resistance of composites appeared to be dictated by the fiber toughness. The later property must be measured in a simulated high-rate condition.
Nonuniform activity distribution in catalyst particles: Benzene hydrogenation on supported nickel in a single pellet diffusion reactor

Abstract A single pellet diffusion reactor (SPDR) of new design has been used to investigate the influence of nonuniform distributions of active ingredient on the Ni-catalyzed hydrogenation of benzene. Five different distributions, ranging from preferential shell-loading to uniform to preferential core loading, have been studied under isothermal conditions. Analysis of results has been carried out using a simple one-dimensional diffusion/reaction analysis, which the configuration of the SPDR is set to mimic. The rate of the reaction follows an Eley-Rideal model, effectively positive fractional-order under the experimental conditions, for which kinetics the nonuniform distribution problem has not been studied experimentally before. Preferential shell-loading yields the highest catalytic effectiveness but because of the complex interactions between the reaction kinetics and the activity profiles within the pellets, there is no simple relationship between diffusion lengths and effectiveness even for large values of the Thiele modulus.
Membrane potentials associated with Ca-induced K conductance in human red blood cells: studies with a fluorescent oxonol dye, WW 781.

A divalent anionic dye, bis-[3-methyl-1-p-sulfophenyl-5-pyrazolone-(4)]-pentamethine oxonol (WW 781) is a rapidly responding fluorescent indicator of KCl diffusion potentials induced in human red blood cells with valinomycin, gramicidin, and with the Ca ionophore A 23187 in the presence of external Ca. WW 781 has a sensitivity of 0.13% ΔF/mV, a detection limit of 10 mV, a response time of less than 1 sec, and exhibits a decrease in fluorescence intensity upon hyperpolarization without detectable shifts in absorption or emission peaks. This dye does not perturb the normal resting potential, and unlike the slow permeant cyanine dyes, does not inhibit Ca-induced K conductance in human red blood cells. However, WW 781 does stimulate Ca-induced unidirectional Rb efflux. With Ca plus A 23187, the initial rapid change in dye fluorescence is sensitive to [Ca] o and to [A 23187], is reversible with excess EGTA, and is inhibited by quinine, oligomycin, and by trifluoperazine. A biphasic dependence of hyperpolarization on K o is evident at pH 6, where the ionic selectivity of activation is K, Rb>Cs>Na and that of conductance is K, Rb>Cs. Conditions were defined which permitted continuous monitoring ofE m for at least 10 min, and the time dependence of the Ca-induced potentials was characterized. Since the properties of the Ca-induced changes in dye fluorescence correlate well with the known characteristics of Ca-induced K permeability, we conclude that WW 781 is a useful indicator of changes inE m, provided that sufficient controls are employed to separate direct effects of Ca on dye fluorescence from the effects ofE m on fluorescence.
Estimation of ocean contribution at the MODIS near-infrared wavelengths along the east coast of the U.S.: Two case studies

[1] Atmospheric correction for the ocean color products derived from the Moderate Resolution Imaging Spectroradiometer (MODIS) uses two near-infrared (NIR) bands centered at 748 and 869 nm. Ocean is usually assumed to be black at these two NIR wavelengths. For Case-2 and high productive Case-1 waters, however, ocean could have significant contributions in the NIR, leading to significant under-estimation of the MODIS-derived water-leaving radiances. This is often the case in coastal regions. In this paper, measurements from the MODIS Terra at the short wave infrared (SWIR) wavelengths (1240 and 1640 nm) are used to evaluate the ocean contributions at wavelengths 748 and 869 nm. The ocean is black in coastal regions in these SWIR bands due to much stronger water absorption. Studies of two MODIS granules off the east coast of the U.S. show that the ocean could have reflectance values of ∼3.1% and ∼1.8% at the top of atmosphere (TOA) for bands 748 and 869 nm in the Outer Banks, while these values are ∼0.15% and ∼0.1% in the Chesapeake Bay region. Thus, for the turbid waters, it is important to accurately account for the ocean contributions in the NIR bands for the atmospheric correction of ocean color remote sensing.
Effect of monoclonal antibodies (MoAb) to class I and class II HLA antigens on lectin- and MoAb OKT3-induced lymphocyte proliferation.

Abstract We have examined the effect of several monoclonal antibodies (MoAb) to monomorphic determinants of class II HLA antigens, and MoAb to monomorphic determinants of class I HLA antigens and to beta-2-microglobulin (β2-μ) on lectin- and MoAb OKT3-induced proliferation of human peripheral blood mononuclear cells (PBMNC) and cultured T cells (CTC). Some, but not all, anti-class II HLA MoAb inhibited the proliferative response of PBMNC to MoAb OKT3 and pokeweed mitogen (PWM). The degree of inhibitory effect varied considerably. This effect was not limited to anti-class II HLA MoAb since anti-class I HLA MoAb and anti-β2-μ MoAb also inhibited MoAb OKT3- or PWM-induced proliferative responses. In contrast, the response of PBMNC to phytohemagglutinin (PHA) and concanavalin A (Con A) was not blocked by any anti-class II HLA MoAb. However, some anti-class II HLA MoAb also inhibited the proliferative response of CTC plus allogeneic peripheral blood adherent accessory cells (AC) to PHA or Con A as well as to MoAb OKT3 or PWM. This may be attributable to the substantially greater class II HLA antigen expression by CTC than by fresh lymphocytes. Pretreatment of either CTC or AC with anti-class II HLA MoAb inhibited OKT3-induced proliferation. In contrast, pretreatment of CTC, but not AC, with anti-class I HLA MoAb inhibited the proliferative response of CTC to OKT3. Pretreatment of CTC with anti-class I HLA MoAb inhibited PHA-, Con A and PWM-induced proliferation, to a greater degree than the anti-class II HLA MoAb. It appears as if lymphocyte activation by different mitogens exhibits variable requirements for the presence of cells expressing major histocompatibility determinants. Binding of Ab to membrane markers may interfere with lymphocyte-AC cooperation, perhaps by inhibiting binding of mitogens to their receptors or by interfering with lymphocyte and AC function. We also have examined the role of class II HLA antigens on CTC by depleting class II HLA-positive cells. As expected, elimination of class II HLA-positive AC with anti-class II HLA MoAb plus complement caused a decrease in proliferation of CTC in response to all the mitogens tested. In contrast, elimination of class II HLA-positive CTC was shown to clearly increase proliferation of CTC, perhaps because this may deplete class II HLA-positive suppressor cells.
Synthesis and Characterization of the Surfactant Terbium 3-[[1,2-Bis-[[(2-Ethylhexyl)Oxy]Carbonyl]Ethyl]Thio]Succinate as a Reagent for Determining Organic Analytes

The surfactant terbium 3-[[1,2-bis[[(2-ethylhexyl)oxy]carbonyl]ethyl]thio]succinate has been synthesized and characterized by use of its absorption, luminescence, and microviscosity properties. In the presence of small amounts of water, this surfactant aggregates in cyclohexane to form reversed micelles containing Tb(III) counterions. The critical reverse micelle concentration has been determined to be 5.7 × 10-5 M with the use of an optical probe. Organic analytes solubilized in reverse micelles have been detected indirectly with the use of the luminescence characteristics of Tb(III) counterions. The detection scheme is based on energy transfer from the solubilized organic donor to acceptor Tb(III) counterions. Analytical figures of merit for the micellar system in the presence of organic analytes are presented. The microviscosity of the reverse micellar core has been estimated with the use of a viscosity-sensitive luminescent probe.
Organocerium additions to proline-derived hydrazones: synthesis of enantiomerically enriched amines

Abstract The addition of organocerium reagents (from both organolithium and organomagnesium precursors) to chiral aldehyde hydrazones prepared from 1-aminoproline derivatives has been studied. The additions proceed in good yield and high diastereoselectivity and with good nucleophile (Me, n-Bu, i-Pr, t-Bu, Ph, etc.) and substrate scope (alkyl, alkenyl and aryl). The resulting hydrazines can be converted to amines by N–N bond cleavage through hydrogenolysis (Raney nickel) or by acylation and cleavage with Li/NH3. The influence of the side chain on the diastereoselectivity was investigated through variation of the substituents to include more coordinating atoms (oxygen and nitrogen) as well as the removal of coordinating atoms. The SAMEMP auxiliary bearing a 2-methoxyethoxymethyl group gave the highest diastereoselectivities. Remarkably, auxiliaries bearing simple methyl and isobutyl substituents gave high selectivities as well. Hypotheses for the origin of the selectivity are presented.
EXPERIMENTS WITH PRIORITY DISPATCHING RULES IN A PARALLEL PROCESSOR SHOP

SUMMARY A parallel processor shop was modeled in order to simulate its performance, with respect to certain criteria, when jobs were dispatched to machines by various priority dispatching rules. Several rules which have shown good performance in pure job shop studies, as well as a new weighted objective rule, were tested in the modeled environment. The rules performed much as would have been expected from reviewing job shop literature. However, some interesting differences were observed. In general, the performance of the shop was substantially improved by using the priority rules.
Endotoxin-mediated Limulus proclotting enzyme activator and detection of a previously undescribed protease(protease N)

Proclotting enzyme activating factor, designated activator, that participates in endotoxin(lipopolysaccharide, LPS)-mediated Limulus coagulation, has been purified by a combination of heparin-Sepharose and benzamidine-Sepharose chromatography. The purified activator was inhibited by DFP and several trypsin inhibitors and hence characterized as a trypsin-type serine protease. Molecular weight analysis of the activator revealed that the intact molecule(M.W., 50,000) probably consisted of two identical subunits(M.W., 22,000). The subunit was composed of multiple polypeptide chains, including a heavy chain(M.W., 17,000), linked by disulfide bond(s). The results indicated that the activator molecule does not form a macromolecular complex with LPS but rather undergoes limited proteolysis during LPS-mediated activation of proactivator. Thus, activation of the proactivator is likely to be produced by conversion of the proactivator to an active form by a proteolytic enzyme, e.g., an LPS-dependent protease(Protease N), newly identified in these studies.
Histone 1.2, Another Housekeeping Protein that Kills

Histone 1.2, a housekeeping protein that binds nucleosomal linkers, has recently been identified as an apoptogenic factor released from the nucleus to the cytosol in response to double strand DNA breaks. In the cytosol, it promotes the activation of proapoptotic Bcl-2 family proteins, mitochondrial cytochrome c release, and ultimately, cell death.
A Logarithmic Complexity Divide and Conquer Algorithm for Flexible Multibody Dynamics

This paper presents an efficient algorithm for parallel implementation of multi-flexible-body dynamics systems simulation and analysis. The effective overall computational cost of the algorithm is logarithmic when implemented with a processor optimal O(n) processors. This algorithm formulates and solves the nonlinear equations of motion for mechanical systems with interconnected flexible bodies subject to small elastic deformation together with large rotations and translations. The large rotations or translations are modeled as rigid body degree of freedom associated with the interconnecting kinematic joint degrees of freedom. The elastic deformation of the component bodies is modeled through the use of admissible shape functions generated using standard finite element analysis software or otherwise. Apart from the approximation associated with the elastic deformations, this algorithm is exact, non-iterative and applicable to generalized multi-flexible chain and free topologies.Copyright © 2005 by ASME
Origin of Two-Electron, One-Photon K —X-Ray Transitions

Hartree-Fock energy and intensity calculations show that the two-electron, one-photon ${K}^{2}\ensuremath{-}{L}^{2}$\char22{}x-ray transitions recently reported are due to $1{s}^{\ensuremath{-}2}\ensuremath{\rightarrow}2{s}^{\ensuremath{-}1}2{p}^{\ensuremath{-}1}$ electric dipole transitions. The mechanism which we use to describe the $1{s}^{\ensuremath{-}2}\ensuremath{\rightarrow}2{s}^{\ensuremath{-}1}2{p}^{\ensuremath{-}1}$ transition is based on a "shake-down" model.
Percolation and Deconfinement

Abstract Possible phase transition of strongly interacting matter from hadron to a Quark-Gluon Plasma (QGP) state have in the past received considerable interest. It has been suggested that this problem might be treated by percolation theory. The Color String Percolation Model (CSPM) is used to determine the equation of state (EOS) of the QGP produced in central Au-Au collisions at RHIC energies. The bulk thermodynamic quantities - energy density, entropy density and the sound velocity - are obtained in the framework of CSPM. It is shown that the results are in excellent agreement with the recent lattice QCD calculations(LQCD).
Generations of a third-order folded structure for chromatin.

Abstract A model for the initiation of the diffuse-condensed transition of chromatin induced by a change in the conformation of lysine-rich histones is proposed. Three levels of folded structures are discussed. The first-order folded structure refers to the structure of the repeat unit of chromatin, which is called the nucleosome. The nucleosome contains a nuclease resistant region in which 140 base pairs of DNA are wrapped around the surface of a histone aggregated of two copies each of the histones H2A, H2B, H3 and H4. This DNA-histone aggregate is called a core particle. The nuclease accessible region of the nucleosome is approximately 60 base pairs of DNA which link the core particle, hence the terminology “linker DNA.” The lysine-rich histones, (Hl, H5), which are more loosely bound than the core histones, are associated with the linker DNA. The second-order folded structure refers to the conformation of a polynucleosome. Based on neutron scattering and quasielastic light scattering studies the second-order folded structure is assumed to be an extended helix in solution with 5–7 nucleosome units per turn. The third-order folded structure is defined as that structure resulting from the first stage in the condensation process induced by a conformational change in the lysine-rich histones. Generation of the third-order folded structure in the proposed model is effected by an increased affinity of the lysine-rich histones for super-helical DNA in the core particles in adjacent turns of the second-order folded structure. Since the lysine-rich histones preferentially bind to A-T rich regions in DNA, the distribution of these regions would determine the third-order folded structure. The net effect of a non-random distribution of A-T rich regions as in the proposed model is the generation of a helix for the third-order folded structure. The assumption of a non-random distribution of A-T rich regions is indirectly supported by proflavine binding studies reported herein and by the existence of repetitive and non-repetitive DNA regions inferred from renaturation studies. One consequence of the proposed mechanism is that the majority of the A-T rich regions are in the interior of the third-order folded structure. Promoter sites of high A-T content would then be inaccessible to polymerases. The proposed model also suggests a role for spacer DNA in the genome. Higher order folded structures must also be present in the final state of condensed chromatin since the three orders of folded structures considered in this communication accounts for only 2% of that required in the diffuse-condensed transition.
UnISIS: a laser-guided adaptive optics system for the Mt. Wilson 2.5-m telescope

Final design details are given for UnISIS, the University of Illinois Seeing Improvement System. The principle components include a 50 Watt Excimer laser working at 351 nm which produces a pulsed Rayleigh laser guide star at 333 Hz and 18 km altitude, a 177-actuator deformable mirror, an atmospheric dispersion correction system, and a science camera configuration with both visual and near-IR cameras that can be used simultaneously. Two high-speed CCD cameras are used to feed dual quad C40 DSP-based reconstructor to close the feedback loop with the deformable mirror. The adaptive optics system is situated on a large optics table that rests above the old Coude spectrograph of the Mt. Wilson 2.5-m telescope and the Excimer laser is located in a basement Coude room.
Children's Behavior During Immunization Injections: A Principle Components Analysis

Observational assessment is an important component of a comprehensive evaluation of children's procedural pain. An understanding of children's behavior during painful procedures can inform the structure of these measures and is important in the development of effective interventions. This study used principle components analyses to evaluate the structure of children's behavior during routine immunizations. Videotapes of 159 children undergoing routine immunizations were coded using the Child-Adult Medical Procedure Interaction Scale (Blount et al., 1989). Results indicated a 4-component solution was the most appropriate categorization and accounted for 61.2% of the variance in children's behavior. The first 3 components represented “verbal fear” (seeking emotional support, verbal fear, information seeking), “vocal pain” (cry, verbal resistance, verbal pain), and “escape behavior” (need for restraint, flail). The final component, “other verbal behavior” consisted of nonprocedural talk and negative verbal e...
From quantum entanglement to mirror neuron

Abstract It is proposed that two fundamental phenomena: quantum entanglement in physics, and mirror neuron in biopsychology, can be described by using the same mathematical formalism, namely, the feedback from the Liouville equation to equation of motion.
Markov Processes with Constant Transition Rates of Size One & Two

The two classical single server queueing systems, M/M/1 and M/M/1/N are generalized to allow constant transition rates of size two in addition to the standard constant transitions rates of size one. In terms of the queueing models, these new systems each allow customers to arrive or be served instantly in pairs as well as individually. The steady state distributions are explicitly determined and a condition for the existence of a steady state distribution is established in the infinite-state space case. Assuming that a steady state condition prevails, the canonical performance measures are determined. Expressions for the average number of customers in either system or queue are derived. Formulae for the average waiting time that a customer spends in each system or queue are also developed.
Thermal analysis of dry eye subjects and the thermal impulse perturbation model of ocular surface.

In this study, we explore the usage of ocular surface temperature (OST) decay patterns to distinguished between dry eye patients with aqueous deficient dry eye (ADDE) and meibomian gland dysfunction (MGD). The OST profiles of 20 dry eye subjects were measured by a long-wave infrared thermal camera in a standardized environment (24 °C, and relative humidity (RH) 40%). The subjects were instructed to blink every 5 s after 20 ∼ 25 min acclimation. Exponential decay curves were fit to the average temperature within a region of the central cornea. We find the MGD subjects have both a higher initial temperature (p < 0.022) and a higher asymptotic temperature (p < 0.007) than the ADDE subjects. We hypothesize the temperature difference among the subpopulations is due to tear volume and heat transfer mechanisms. To study the validity of our claim, we develop a mathematical model, referred to as the thermal impulse perturbation (TIP) model. We conclude that long-wave-infrared thermal imaging is a plausible tool in assisting with the classification of dry eye patient.
Quantum efficiency measurements for several waveshifter coatings in the extreme vacuum ultraviolet.

Quantum efficiency measurements are given for coronene and liumogen coatings designed to enhance UV sensitivity for silicon charge coupled device imaging detectors. Coatings on quartz and on UDT PIN 10DP photodiodes were tested. The wavelength range extended from 153.7 to 50.0 nm in the vacuum ultraviolet. Similar measurements were made for coronene, liumogen, and stilbene-3 laser dye films on quartz disks relative to sodium salicylate. Sodium salicylate and coronene are the most efficient waveshifters down to 50 nm so far observed. Coronene's fairly constant quantum efficiency over such a wide wavelength range into the far VUV makes it a useful waveshifter for UV and VUV applications.
Nontranslation of foreign genetic information for fraction 1 protein under circumstances favorable for direct transfer ofNicotiana gossei isolated chloroplasts intoN. Tabacum protoplasts

The nuclei and cytoplasm ofN. gossei andN. tabacum are compatible to the extent that reciprocal, interspecific F1 hybrids can be produced by conventional breeding techniques. Conditions were established in which manyN. gossei isolated chloroplasts could be seen by phase and fluorescence microscopy to adhere to 40% of the population of protoplasts obtained from white tissue of variegatedN. tabacum plants and to remain attached after washing the protoplasts. Chloroplasts also could be seen to enter the interior of the protoplasts. After treating albino protoplasts withN. gossei chloroplasts, the protoplasts were subjected to further conditions whereby 65 calluses containing shoots developed. TwentyN. tabacum protoplasts not treated with foreign chloroplasts also produced calluses with shoots to serve as a control. All calluses developed chlorophyll irrespective of whether or not the albino protoplasts had been treated with isolatedN. gossei chloroplasts. The Fraction 1 protein ofN. tabacum has a different electrophoretic mobility from the protein ofN. gossei or anN. gossei xN. tabacum F1 hybrid. The Fraction 1 protein large subunit is coded by chloroplast DNA, whereas the small subunit is coded by nuclear DNA. Fraction 1 protein was isolated from the variegated shoots of the 65 calluses obtained after treating albino protoplasts with foreign chloroplasts. Immunoelectrophoresis demonstrated the protein from each callus to have a mobility identical toN. tabacum protein. Therefore, under circumstances highly favorable for the direct transfer ofN. gossei isolated chloroplasts (and possibly nuclei also) intoN. tabacum protoplasts, no evidence was obtained to suggest that genetic information contained in the isolated foreign organelles was being translated into the polypeptides of either the large or small subunits of Fraction 1 protein contained in newly differentiated leaves derived from the protoplasts.
Effects of hetastarch resuscitation on extravascular lung water and cardiopulmonary parameters in a sheep model of hemorrhagic shock.

Eight sheep, weighing 29–71 kg, were used to evaluate the cardiopulmonary response to Hespan® infusion following shock. Before shock was induced, mean arterial pressure (MAP), pulmonary capillary wedge pressure (PCWP), pulmonary artery pressure (PAP), cardiac output (CO), extravascular lung water (EVLW), colloid oncotic pressure (COP), and hemoglobin were measured and shunt, arteriovenous oxygen content difference (C[a - v]O2) and COP-PCWP gradient were calculated. The animals were bled to a MAP of 50 mmHg and that level was maintained for 30 min. At the end of that time, the data were collected again. The animals were resuscitated back to baseline values of PCWP, MAP, and CO with a 6% hydroxyethylstarch solution. With shock, PCWP, MAP, CO, and arterial pH decreased and C(a - v)O2 increased significantly (P < 0.05). With resuscitation, PAP, PCWP and CO were significantly greater than baseline. Arterial pH was less than the baseline value but was within normal range. MAP did not return to preshock levels. EVLW and venous admixture did not change at any time.C(a - v)O2 returned to baseline with resuscitation. Volume of hetastarch infused was 29.1 ± 10 cm3/kg. We conclude that hetastarch is an effective resuscitation solution in a model of hemorrhagic shock and appears to have no adverse cardiopulmonary effects.
Isoflurane preconditioning reduces purkinje cell death in an in vitro model of rat cerebellar ischemia

Abstract We monitored survival of Purkinje cells in rat cerebellar slices to test the hypothesis that isoflurane preconditioning reduces ischemia-induced neuronal death. Preconditioning the brain slices with isoflurane, a volatile anesthetic commonly used in clinical practice, at 1–4% for 15 min at 37 °C significantly decreased Purkinje cell injury and death caused by a 20-min ischemia (simulated by oxygen–glucose deprivation, OGD). The effective concentration for half of the maximal effect (EC 50 ) for this isoflurane preconditioning-induced neuroprotection was 1.17±0.31% and the maximal protective effects were achieved at 3% or higher concentrations of isoflurane. In addition, preconditioning the cells with isoflurane for 15–30 min was needed for the preconditioning to be maximally protective. Although farnesyl protein transferase inhibitor III blocked the protective effects of OGD preconditioning (a 3-min OGD 15 min before the 20-min OGD), this inhibitor did not affect the neuroprotection induced by isoflurane preconditioning. While dl -threo-β-hydroxyaspartic acid (THA), a specific glutamate transporter inhibitor, did not change basal OGD-induced cell death rate, THA blocked the neuroprotection induced by isoflurane preconditioning but not by OGD preconditioning. Glybenclamide, a K ATP channel inhibitor, did not block the neuroprotection induced by either isoflurane or OGD preconditioning. Our results suggest that isoflurane preconditioning is neuroprotective. The isoflurane concentrations and times needed for the preconditioning to be neuroprotective are clinically relevant. The mechanisms of this protection seem to involve modulation of glutamate transporter activity.
Interhemispheric processing in left- and right-handers.

Inter- and intrahemispheric processing for left- and right-handers were compared in two experiments. In one, subjects performed a digit-matching task and in the other they decided if two letters were part of a previously presented word. On some trials the matching items were presented initially only to one hemisphere (within-hemisphere trials), and hence the match descision could be reached by a hemisphere in isolation. On other trials, one item of the match pair was presented to each hemisphere (across-hemisphere trials), requiring interhemispheric interaction for the match decision. Patterns of performance on within-as compared to across-hemisphere trials were identical for the two handedness groups in both experiments. Furthermore, individual characterisitics of subjects such as their hand posture, sex and family history of left-handedness did not affect the pattern of performance. These results suggest that interhemispheric processing may not differ between right- and left-handers.
New clinical aspects of hereditary mucoepithelial dysplasia.

Hereditary mucoepithelial dysplasia (HMD) is a multiepithelial disorder. It is transmitted as an autosomal dominant trait (McKusick: Mendelian Inheritance in Man—Catalogs of Autosomal Dominant, Autosomal Recessive, and X-Linked Phenotypes, 8th edition. Baltimore: The Johns Hopkins University Press, pp 499, 1988). HMD is characterized by variable combinations of lesions of skin, hair, orificial mucosa, gingiva, eyes, and lungs. In some previously described patients, the corneal and pulmonary lesions were progressive and led to blindness, recurrent pneumonia, and/or premature death. On light microscopy, the lesion is characterized by dyskeratosis and, on electron microscopy, by a paucity of gap junctions and desmosomes. Here, we describe a new 5′generation kindred in which affected individuals had the same histologic characteristics but a some-what different clinical spectrum and a more benign course. HMD should be considered in the differential diagnosis of childhood alopecia, follicular hyperkeratosis, keratoconjunctivitis, juvenile cataracts, gingival hyperemia, restrictive lung disease, and esophageal stenosis or webs.
STRATEGIES FOR COPING WITH JOB CHALLENGES IN THE COMMUNITY COLLEGE DEPARTMENT: A COMPARISON OF CHAIR PERCEPTIONS BY WORK EXPERIENCE

Department chairs in community colleges face a number of job‐related challenges that have been well documented by practitioners and scholars. Despite the identification of these challenges, few efforts have been undertaken to develop a battery of coping strategies for them. This study sought to identify and prioritize coping strategies related to the challenges of chairing a department in the community college. In addition, the work experience background of practicing chairs was selected to determine differences in the use of the various coping strategies.
Modification of the 50% maximum dose depth for 41-MeV ( p+,Be) neutrons by use of filtration and/or transmission targets

Several target configurations for the 41-MeV ( p/sup +/,Be) reaction have been evaluated for the characteristics of the radiation field produced; depth dose, dose rate per ..mu..A. From analysis, it is concluded that to achieve the desired 13.2-cm depth for 50% of maximum dose and acceptable dose rate at a target-to-skin distance (TSD) of 125--150 cm, the neutron spectra must be filtered to preferentially absorb the lower-energy neutrons. Further increases in depth of 50% of maximum dose and a significant reduction in beryllium heating problems result if a partial transmission target is used with the terminal 30% of proton energy being deposited in a copper target backing.
Capillary zone electrophoresis of bile acids with indirect photometric detection.

Investigations in our laboratory have demonstrated that capillary zone electrophoresis (CZE) with indirect photometric detection is a viable approach to the separation and identification of free bile acids along with their taurine and glycine derivatives. Various parameters such as pH, organic solvent concentrations, column temperature, and type of chromophore electrolyte were investigated to optimize the electrophoretic separation and to maximize the peak capacity. The quality of separation of bile acids can be dramatically improved by incorporating γ-cyclodextrin (γ-CD) in the running electrolyte. This improvement in resolution is accompanied by a decreased migration time, suggestive of an increase in association of γ-CD with bile acids. As a result, a CZE separation of all 15 bile acids was possible in ∼30 min using 5 mM adenosine 5‘-monophosphate, 7 mM γ-CD in 75% (v/v) methanol at pH 7.0.
On multi-rigid-body system dynamics

Abstract A computer-oriented method for obtaining dynamical equations of motion for large mechanical systems or “chain systems” is presented. A chain system is defined as an arbitrarily assembled set of rigid bodies such that adjoining bodies have at least one common point and such that closed loops are not formed. The equations of motion are developed through the use of Lagrange's form of d'Alembert's principle. The method has been applied with human-body models and finite-segment cable models. The numan-body models are configured to simulate a crash-victim. Results obtained with several deceleration profiles agree very well with available experimental data.
EGG MASS INFLUENCES NESTLING QUALITY IN TREE SWALLOWS, BUT THERE IS NO DIFFERENTIAL ALLOCATION IN RELATION TO LAYING ORDER OR SEX

Maternal allocation of resources to eggs and nestlings can potentially have a profound influence on offspring phenotype and fitness. However, it is often unclear how much of the variation in offspring quality is due to maternal or environmental effects. We examined the influence of maternal and environmental effects on egg mass and nestling quality (growth and immune function) in Tree Swallows (Tachycineta bicolor). There was no evidence that the allocation of maternal resources to eggs varied with laying order or offspring sex. Thus, there was no evidence of adaptive maternal allocation to eggs in terms of mass. Instead, egg mass in Tree Swallows appeared to be influenced primarily by ambient temperature during egg formation and differences among females. Nonetheless, female Tree Swallows were likely to realize substantial benefits from producing larger eggs because those young were larger at hatching and grew faster. Furthermore, nestlings that grew faster had a stronger immune function at 11 days of age. Our results suggest that the positive relationship between nestling growth and survival may be due, in part, to the effects of an enhanced immune response.
Studies of HLA, fertility and mate choice in a human isolate

The role of human leukocyte antigen (HLA) genes in pregnancy and in human mate choice has been investigated in the Hutterites, an inbred population of European origins. High-resolution HLA haplotypes were defined by alleles at 16 loci in >1000 Hutterites. Prospective studies of pregnancy outcome previously demonstrated increased fetal loss rates among Hutterite couples matching for HLA-B antigens (P = 0.033) or for the entire 16-locus haplotype (P = 0.002). Among living children of couples matching for HLA-B or for the haplotype, there was a non-significant deficit of children who were heterozygous and compatible with the mother; the number of living children who were compatible and homozygous or incompatible and heterozygous was not different than expectations (HLA-B, P = 0.095; haplotype, P = 0.376). Mate choice among 411 couples was non-random with respect to the HLA haplotype, assessed by a variety of methods (P = 0.020 to <0.001). These combined data indicate a role for HLA region genes in both pregnancy outcome and mate choice, and suggest that selection acting on these genes occurs pre-conceptually as well as during pregnancy. This review outlines previously published studies on HLA, fertility and mate choice in the Hutterites.
Association of CD44 V3-containing isoforms with tumor cell growth, migration, matrix metalloproteinase expression, and lymph node metastasis in head and neck cancer

Background. The CD44 family of receptors includes multiple variant isoforms, some of which have been linked to tumor progression. The objective of this study was to investigate whether CD44 v3-containing isoforms are involved in head and neck squa- mous cell carcinoma (HNSCC) tumor progression. Methods. Laboratory investigation utilizing HNSCC cell lines and clinical tissue specimens was performed. Results. Investigation of 13 HNSCC cell lines revealed a diversity of CD44 isoform profiles, including expression of CD44 v3-containing isoforms. Two cell lines, HOC313 and MDA1483, were selected for further study based on their CD44 v3 expres- sion profile. The HOC313 cell line, which highly expresses CD44 v3-containing isoforms, demonstrated hyaluronan-mediated CD44-dependent promotion of tumor cell growth and migration. Conditioned media from the HOC313 cell line also exhibited high matrix metalloproteinase expression on gelatin zymography. Immunohistochemical analysis of a series of metastatic HNSCC lymph nodes revealed CD44 overexpression as well as staining for CD44 v3-containing isoforms. Conclusion. CD44 v3-containing isoforms are associated with HNSCC growth, migration, and matrix metalloproteinase ac- tivity and can be identified in lymph node metastasis. V C 2007
Exploratory time varying lagged regression: Modeling association of cognitive and functional trajectories with expected clinic visits in older adults

Motivated by a longitudinal study on factors affecting the frequency of clinic visits of older adults, an exploratory time varying lagged regression analysis is proposed to relate a longitudinal response to multiple cross-sectional and longitudinal predictors from time varying lags. Regression relations are allowed to vary with time through smooth varying coefficient functions. The main goal of the proposal is to detect deviations from a concurrent varying coefficient model potentially in a subset of the longitudinal predictors with nonzero estimated lags. The proposed methodology is geared towards irregular and infrequent data where different longitudinal variables may be observed at different frequencies, possibly at unsynchronized time points and contaminated with additive measurement error. Furthermore, to cope with the curse of dimensionality which limits related current modeling approaches, a sequential model building procedure is proposed to explore and select the time varying lags of the longitudinal predictors. The estimation procedure is based on estimation of the moments of the predictor and response trajectories by pooling information from all subjects. The finite sample properties of the proposed estimation algorithm are studied under various lag structures and correlation levels among the predictor processes in simulation studies. Application to the clinic visits data show the effect of cognitive and functional impairment scores from varying lags on the frequency of the clinic visits throughout the study.
How OHC lesions can lead to neural cochlear hypersensitivity.

Several laboratories, including ours, have found that damage to OHCs—but not to IHCs—can produce hypersensitivity of cochlear nerve afferents to low-frequency sound in the presence of hyposensitivity at the characteristic frequency (CF). It is possible to explain the paradox by a mechanical coupling of the OHCs and IHCs through the tectorial membrane, for which there is accumulating experimental evidence. No direct contact between the IHC stereocilia and the tectorial membrane is required.
An outbreak of Bordetella bronchiseptica pneumonia in a colony of common marmosets (Callithrix jacchus)

An outbreak of Bordetella bronchiseptica pneumonia occurred in a breeding colony of common marmosets (Callithrix jacchus). 16 animals, all except one under 12 months of age, died suddenly. Extensive lesions of pneumonia and pleurisy were found at necropsy and B. bronchiseptica was isolated from the nasopharynx, trachea and lungs. Older animals had only a mild rhinitis. Colonization of the nasal mucosa occurred in 71 of 156 marmosets.
Effect of cocaine self‐administration on dopamine D2 receptors in rhesus monkeys

The present study used autoradiography to examine the effects of chronic self-administration of cocaine on the density of dopamine D2 receptors in nonhuman primates. Three rhesus monkeys intravenously self-administered an average of 1.35 mg/kg cocaine per day for 18-22 months until they were euthanized immediately after a self-administration session. Binding site density of the D2 ligand [3H]raclopride (2 nM) was assessed in these monkeys as well as three untreated controls, using quantitative in vitro receptor autoradiography. As compared to untreated controls, D2 binding site density was significantly lower in the animals that self-administered cocaine in all regions of the striatum rostral to the anterior commissure. These regions include the anterior and central regions of the caudate nucleus, putamen, olfactory tubercle, and both the shell and core of the nucleus accumbens. Within the substantia nigra and ventral tegmental area, by contrast, no differences were found in the density of D2 binding sites. These findings suggest a pervasive effect of cocaine on the regulation of D2 receptors in the striatum. The lack of change within the ventral midbrain, however, suggests a differential regulation of D2 receptors in the striatum and ventral midbrain. This study confirms and extends our knowledge of the neurobiological changes in the mesolimbic dopamine system that result from chronic exposure to cocaine.
Neutrinos from cosmic ray accelerators in the Cygnus region of the galaxy

While supernova remnants have been identified as the most likely sources of the galactic cosmic rays, no conclusive observational evidence for this association exists. We show here that IceCube has the possibility of producing incontrovertible evidence by detecting neutrinos produced by the cosmic ray beam interacting with the hydrogen in the vicinity of the supernova shock expanding into the interstellar medium. We show that the observational information on gamma ray fluxes from the Cygnus region, although limited, is sufficient to pinpoint the expected event rate of the neutrinos associated with a single source of 0.5 Crab at the TeV level to within a factor of 2, between 2 and 3.8 neutrinos per year. Finally, we note that recent gamma-ray observations reveal the presence of at least three and possibly up to eight such sources, raising the possibility of seeing more than 10 neutrinos per year from these sources alone.
REASONING WITH BACKGROUND KNOWLEDGE–A THREE-LEVEL THEORY

We address the problem of reasoning in cases when knowledge bases containing background knowledge are understood not as sets of formulas (rules and facts) but as collections of partially ordered theories. In our system, the usual, two-part logical structures, consisting of a metalevel and an object level, are augmented by a third level–a referential level. The referential level is a partially ordered collection of theories; it encodes background knowledge. As usual, current situations are described on the object level, and the metalevel is a place for rules that can eliminate some of the models permitted by the object level and the referential level. As a logic of reasoning the system generalizes the standard model of a rational agent: deducing actions and deriving new information about the world from a logical theory–its knowledge base. It is a natural logical system in which priorities on the possible readings of predicates, not special rules of inference, are the main source of nonmonotonicity. We introduce a theory forming operator PT(x) to exploit the priorities, and we investigate its basic logical properties. Then we show how such a system can be augmented by metarules. Although this paper concentrates on basic logical properties of the new theory, this formalism has already been applied to model a number of natural language phenomena such as the notion of text coherence, Gricean maxims, vagueness, and a few others. The paper also briefly compares it with the model of background knowledge of CYC, as proposed by Lenat and Guha.
Real time targeted exploration in large domains

A developing agent needs to explore to learn about the world and learn good behaviors. In many real world tasks, this exploration can take far too long, and the agent must make decisions about which states to explore, and which states not to explore. Bayesian methods attempt to address this problem, but take too much computation time to run in reasonably sized domains. In this paper, we present TEXPLORE, the first algorithm to perform targeted exploration in real time in large domains. The algorithm learns multiple possible models of the domain that generalize action effects across states. We experiment with possible ways of adding intrinsic motivation to the agent to drive exploration. TEXPLORE is fully implemented and tested in a novel domain called Fuel World that is designed to reflect the type of targeted exploration needed in the real world. We show that our algorithm significantly outperforms representative examples of both model-free and model-based RL algorithms from the literature and is able to quickly learn to perform well in a large world in real-time.
An exploration of site effects in a multisite trial of OROS-methylphenidate for smokers with Attention Deficit/Hyperactivity Disorder

Background: Multisite trials, the gold standard for conducting studies in community-based settings, can mask variability across sites resulting in misrepresentation of effects in specific sites. In a placebo-controlled trial of osmotic-release oral system methylphenidate (OROS-MPH) as augmentation treatment for smokers with attention deficit hyperactivity/impulsivity disorder (ADHD), three types of sites were selected according to their clinical research specialty (ADHD, smoking cessation, and general mental health). Objective: Analysis was conducted to determine if clinical outcomes, that is, reduction in ADHD symptoms and smoking cessation rates, and the effect of treatment on these outcomes would differ by type of site. Method: A total of 255 adult smokers diagnosed with ADHD were enrolled in three clinic types: 72 in ADHD, 79 in tobacco dependence, and 104 in the mental health clinics. Results: The three site-types were similar in demographic characteristics, smoking history, baseline level of ADHD sy...
Coupling into and scattering from cylindrical structures covered periodically with metallic patches

Circular cylindrical structures covered periodically with metallic patches are considered. After an analogy to planar periodic surfaces is shown, formulations are presented for calculating induced currents on the curved surface. The equations are solved and results calculated for the specific case of periodic strips on the cylindrical surface. For a cylindrical structure a two-dimensional periodicity exists, as in a planar structure, while a spherical structure allows only a rotational periodicity. When the cylindrical structure is excited by the characteristic harmonic of the system, the spectral response of the transmitted field exhibits resonances that depend on the surface periodicity, as is known for planar structures. Since the cylindrical structure contains finite closed regions, the effects of resonances internal to the structure are seen and give additional information as compared to planar structures. >