cssi/SciSciGPT-SciSciNet huggingface dataset:
Melatonin: data consistent with a role in controlling ovarian function

FSH and LH excretion were correlated with melatonin excretion in consecutive daily urines obtained from a normal adult female (27 days), a normal 11-year-old girl (28 days), and an 8-year-old girl with idiopathic sexual precocity (30 days). Additionally pregnanediol-3-glucuronide (PG) excretion was determined in the urines of the adult female. Gonadotropin and PG excretion patterns of the adult female were those associated with a normal menstrual cycle. Excretion of melatonin, mean +/- SD, (11.3 +/- 2.7 vs 4.7 +/- 1.4 ng/h, p less than 0.005) was greater and PG (38.3 +/- 81 vs 124.2 +/- 46.7 ug/h, p less than 0.005) was less during the first 13 days as compared to the subsequent 14 days. Gonadotropin and melatonin excretions correlated positively (first 13 days FSH, r = 0.828; rs = 0.815 and LH, r = 0.816; rs = 0.905, p less than 0.005 and subsequent 14 days FSH, r = 0.607; rs = 0.685, p less than 0.025 and LH, r = 0.490, p less than 0.05; rs = 0.638, p less than 0.025). Excretion of PG and melatonin did not correlate during the first 13 days. However, during the subsequent 14 days they correlated negatively (r = -0.679, p less than 0.005; rs = -0.620, p less than 0.025). During the 28-day period the gonadotropin and melatonin excretion patterns of the 11-year-old girl showed random fluctuations and correlated positively (FSH, r = 0.669; rs = 0.631 and LH, r = 0.690; rs = 0.695, p less than 0.005).(ABSTRACT TRUNCATED AT 250 WORDS)
Immediate and delayed recognition of visual stimuli in poor and normal readers.

Abstract The present study investigated the hypothesis that specific reading disability is attributable to inadequate visual memory. Previous research had demonstrated that poor readers sustain no basic dysfunction in visual perception, but there was need to evaluate the possibility that deficiencies in letter and word recognition result from disorder in long-term visual storage. Adopting a format employed in a previous study, randomly arranged Hebrew letters were presented to poor and normal readers unfamiliar with Hebrew, and both groups were asked to demonstrate retention for these stimuli on three separate occasions: immediately after initial presentation, 24 hours later and 6 months later. As a control measure, the performance of the non-Hebrew subjects was compared with that of normal readers familiar with Hebrew letters. It was found that retention in the non-Hebrew groups was equivalent under all of the temporal conditions, but the performance of both was poorer than the Hebrew groups under the immediate and 24-hour conditions. However, none of the reader groups differed in the case of retention after a 6-month delay period. It was concluded that deficient visual memory is an unlikely source of specific reading disability, and alternative explanations of the disorder were considered.
Learning To Read Each Other: Black Female Graduate Students Share Their Experiences at a White Research I Institution

This paper uses Black Feminist Thought to explain the lived experiences of three Black female graduate students at a White Research I institution. Through mentoring from Black female professors, the students received instrumental and psychosocial support that helped them to navigate through their graduate level work. Common themes of identity, community service missions, and empowerment provides a thread that ties the student’s narratives together. We close by offering some suggestions for further research on the Black graduate experience and mentoring Black graduate students.
On the consistency of electromagnetic form factors and ππ scattering in the ρ(1600) region

A two channel doubly-subtracted dispersion relation representation of the 2π and 4π electromagnetic form factors is constructed from a predetermined two-channel ρ-wave ππ-scattering amplitude. We find that a good representation of the pion form factor can be achieved but only at the expense of theF4π form factor. It seems to be difficult to reconcile all of the data in the ρ(1600) region within a two resonance framework indicating additional rho-like resonant structure in this energy region.
Moiré Interferometry Analysis of Fracture

Moire interferometry with a low density grating was used to evaluate the suitability of the T* e integral and CTOA as ductile fracture parameters for characterizing low cycle fatigue and dynamic crack growth in thin aluminum fracture specimens. Phase shifting Moire interferometry with a high density grating was also used to determine the energy dissipation mechanism in brittle alumina ceramics.
Effect of Octreotide on Refractory AIDS-associated Diarrhea: A Prospective, Multicenter Clinical Trial

Objective To determine the efficacy and safety of octreotide for treatment of refractory, profuse diarrhea in patients with the acquired immunodeficiency syndrome (AIDS). Design A prospective, open-label study. Setting Inpatient metabolic units of four university medical centers. Patients Fifty-one patients infected with human immunodeficiency virus (HIV) who had uncontrolled diarrhea (greater than or equal to 500-mL liquid stool per day) despite treatment with maximally tolerable doses of antidiarrheal medications. Intervention After initial baseline studies, patients received octreotide, 50 micrograms every 8 hours for 48 hours. If stool volume was not reduced to less than 250 mL/d, the dose of octreotide was increased stepwise to 100, 250, and 500 micrograms. Main results Fifty men and one woman (mean age, 36.3 +/- 1.1 years) entered and completed the 28-day protocol (14 days of inpatient therapy and 14 days of outpatient therapy). Stool frequency and volume decreased significantly (6.5 +/- 0.5 stools per day on day 0 compared with 3.8 +/- 0.3 stools per day on day 21 [P less than 0.001] and 1604 +/- 180 mL/d on day 0 compared with 1084 +/- 162 mL/d on day 14 [P less than 0.001], respectively). Twenty-one patients (41.2%) were considered to be partial or complete responders (reduction in daily stool volume by greater than or equal to 50% of initial collections or reduction to less than or equal to 250 mL/d). Of the 21 responders, 14 (67%) had no identifiable pathogens at initial screening compared with 9 of 30 (30%) nonresponders (P less than 0.01). Conclusion Patients with AIDS-associated refractory watery diarrhea, especially those without identifiable pathogens, may respond favorably to subcutaneously administered octreotide. This drug deserves further study in a randomized, placebo-controlled trial.
Natriuretic peptides for the treatment of acute heart failure: a focus on nesiritide in recent clinical trials

Nesiritide, a recombinant form of B-type natriuretic peptide, is a vasodilator and currently recommended as an additive therapy for patients with acute decompensated heart failure (ADHF) who have been optimized on loop diuretics. With hospitalizations for ADHF rising, appropriate selection of therapy becomes even more important to optimize efficacy and reduce adverse events. Nesiritide has many properties that antagonize the pathophysiologic processes of heart failure and has demonstrated a comparative benefit in previous reports; however, controversy still remains with respect to its efficacy and safety. Based on results from recent clinical trials, nesiritide has been shown to be safe at currently approved doses and strongly considered for the treatment of ADHF in patients who remain symptomatic despite optimal doses of intravenous loop divertics.
A four load method for evaluation of acoustical source impedance in a duct

A new and simple method to evaluate the acoustical source impedance in a duct is presented. In the method (termed the Four Load Method) the sound pressure level data measured downstream for four different length ducts, as acoustic loads, is used. The simplicity of the method is due to the fact that neither cross-spectra nor complex pressure measurements are required. Also, a second signal generating source is not needed. In addition, the sound pressure level measurements can be made either inside or outside the finite length duct. In order to verify the method, the insertion loss of a simple expansion chamber is predicted by using the source impedance evaluated by the four load method. Excellent agreement is observed between the predicted and measured insertion loss. Some applications of the four load method to duct acoustic studies, including the mean flow case, are discussed.
Making a scene: alignment of complete sets of clips based on pairwise audio match

As the amount of social video content captured at physical-world events, and shared online, is rapidly increasing, there is a growing need for robust methods for organization and presentation of the captured content. In this work, we significantly extend prior work that examined automatic detection of videos from events that were captured at the same time, i.e. "overlapping". We go beyond finding pairwise matches between video clips and describe the construction of scenes, or sets of multiple overlapping videos, each scene presenting a coherent moment in the event. We test multiple strategies for scene construction, using a greedy algorithm to create a mapping of videos into scenes, and a clustering refinement step to increase the precision of each scene. We evaluate the strategies in multiple settings and show that a greedy and clustering approach results in best possible balance between recall and precision for all settings.
Multiculturalism Without Culture and Justice, Gender, and the Politics of Multiculturalism

Multiculturalism Without Culture. By Anne Phillips. Princeton: Princeton University Press, 2007. 216p. $29.99 paper.These latest contributions to the multiculturalism literature have much to recommend them, and—in light of their many affinities—they are particularly rewarding to read as a pair. Both Sarah Song and Anne Phillips start with the same preoccupation, namely, the apparent tension between the importance of respecting cultural diversity on the one hand, and the feminist project of achieving gender equality, on the other. Both are absolutely committed to the latter, of course, but both are also concerned that the feminist backlash against multiculturalism—posed most forcefully and famously by Susan Moller Okin—might have been carried too far. Accordingly, both aim to recover and reconstruct what is worthwhile from the multiculturalism program in a manner that can be reconciled with a commitment to gender equality.
Network-theoretic classification of parallel computation patterns

Parallel computation in a high-performance computing environment can be characterized by the distributed memory access patterns of the underlying algorithm. During execution, networks of compute nodes exchange messages that indirectly exhibit these access patterns. Identifying the algorithm underlying these observable messages is the problem of latent class analysis over information flows in a computational network. Towards this end, our work applies methods from graph and network theory to classify parallel computations solely from network communication patterns. Pattern classification has applications to several areas including anomaly detection, performance analysis, and automated algorithm replacement. We discuss the difficulties encountered by previous efforts, introduce two new approximate matching techniques, and compare these approaches using massive datasets collected at Lawrence Berkeley National Laboratory.
ALTERATION OF URINARY EXCRETION OF ANDROGENS BY ESTROGENIC THERAPY1,2

SOME MEMBERS of our group (i) have reported previously that urinary titers of androgens are decreased by injections of estrogens. The present communica-tion is concerned with an extension of these studies to include a larger number of patients who were treated with diverse estrogens, administered orally and by in-jection. Urine was hydrolyzed and extracted prior to quantitation by a method described by Cuyler and Baptist (2). The colorimetric method of Oesting (3) was employed for the estimation of total androgenic titers. Consecutive 24-hour specimens of urine were examined prior to initiation of therapy for intervals which ranged from 9 to 28 days in order to establish each patient's average daily excretion of androgens during the pretreatment period. During one or more series of therapy, daily 24-hour speci-mens of each patient were titrated for intervals which varied from 5 to 26 days. Only treatment which was given during the periods when hormonal titrations were being made are reported.
Peirce, logic diagrams, and the elementary operations of reasoning

This paper describes Peirce's systems of logic diagrams, focusing on the so-called ''existential'' graphs, which are equivalent to the first-order predicate calculus. It analyses their implications for the nature of mental representations, particularly mental models with which they have many characteristics in common. The graphs are intended to be iconic, i.e., to have a structure analogous to the structure of what they represent. They have emergent logical consequences and a single graph can capture all the different ways in which a possibility can occur. Mental models share these properties. But, as the graphs show, certain aspects of propositions cannot be represented in an iconic or visualisable way. They include negation, and the representation of possibilities qua possibilities, which both require representations that do not depend on a perceptual modality. Peirce took his graphs to reveal the fundamental operations of reasoning, and the paper concludes with an analysis of different hypotheses about...
Comparison Between Experimental and Simulation Results for Ion Beam and Neutron Irradiations in Silicon Bipolar Junction Transistors

We report on an early-time inverse gain comparison between ion and neutron irradiated silicon bipolar junction transistors. We find ion irradiations to be an excellent simulator for fast-burst neutrons for early-time behavior and damage creation rates. In addition we report on an experimental to simulation comparison of transient gain annealing response. The simulations are from a physics based modeling approach that is being developed at Sandia National Laboratories as part of the Qualification Alternatives to the Sandia Pulsed Reactor (QASPR) Program. We find excellent agreement between simulation and experiment across a wide range of irradiation conditions.
Correlation between pain response and improvements in patient-reported outcomes and health-related quality of life in duloxetine-treated patients with diabetic peripheral neuropathic pain.

Objective We assessed whether quality of life (QoL) improvement in duloxetine-treated patients with diabetic peripheral neuropathic pain (DPNP) correlates with the extent of pain relief.
Adaptive web caching: towards a new global caching architecture

Abstract An adaptive, highly scalable, and robust web caching system is needed to effectively handle the exponential growth and extreme dynamic environment of the World Wide Web. Our work presented last year sketched out the basic design of such a system. This sequel paper reports our progress over the past year. To assist caches making web query forwarding decisions, we sketch out the basic design of a URL routing framework. To assist fast searching within each cache group, we let neighbor caches share content information. Equipped with the URL routing table and neighbor cache contents, a cache in the revised design can now search the local group, and forward all missing queries quickly and efficiently, thus eliminating both the waiting delay and the overhead associated with multicast queries. The paper also presents a proposal for incremental deployment that provides a smooth transition from the currently deployed cache infrastructure to the new design.
Intrauterine device use in an urban university clinic: safety of use in a population at high risk for sexually transmitted infections

Abstract Objective The objective was to describe infection rates after intrauterine device (IUD) placement at an urban teaching hospital that did not restrict IUD eligibility based on risk factors for sexually transmitted infections (STIs). Methods We reviewed charts of patients undergoing IUD placement at the University of Chicago obstetrics and gynecology resident clinic from July 2007 to June 2008 ( n =283). The primary outcome was diagnosis of pelvic inflammatory disease (PID) within 12 months. Results Almost half (49.5%) of patients reported a history of any STI. Two patients (0.7%) were diagnosed with PID. Conclusion Postplacement infection in this unrestricted population was infrequent and comparable to reported rates in previous studies.
Dietary K Determines NaCl Sensitivity in NaCl-Induced Rises of Blood Pressure in Spontaneously Hypertensive Rats

The current study tested whether the spontaneously hypertensive rats (SHR) from Charles River Laboratories are resistant or not to NaCl-induced rises of blood pressure and stroke deaths. These rats are fairly NaCl-resistant on a 2.1% high K diet, whereas they are quite susceptible to NaCl-induced hypertension and stroke deaths on a 0.5% normal K diet. Thus, a high K diet strongly protects against an NaCl-induced rise of blood pressure as well as stroke deaths in these SHR rats. Hence the level of dietary K determines the degree of NaCl sensitivity in these SHR rats.
NCAR_Topo (v1.0): NCAR global model topography generation software for unstructured grids

Abstract. It is the purpose of this paper to document the NCAR global model topography generation software for unstructured grids (NCAR_Topo (v1.0)). Given a model grid, the software computes the fraction of the grid box covered by land, the grid-box mean elevation (deviation from a geoid that defines nominal sea level surface), and associated sub-grid-scale variances commonly used for gravity wave and turbulent mountain stress parameterizations. The software supports regular latitude–longitude grids as well as unstructured grids, e.g., icosahedral, Voronoi, cubed-sphere and variable-resolution grids.
The Appalachian Program: Progress, Problems, and Outlook

APPALACHIA is important as a region' because a very great gap exists between its stage of socioeconomic development and other developed regions; moreover, this gap is widening rather than closing. The problem, therefore, is first to arrest the spread in the gap, and, second, to find means, over some span of time, to narrow it. The conscience of an affluent nation is disturbed and it wants to solve, right now, the problems it permitted to develop over the past three to five generations. Therefore, now is the time for an extraordinary effort to bring about adjustment in socioeconomic progress. Also, now is the time for a comprehensive research effort which relates culture, socioeconomic goals, and the use of nature's resources for a well-distributed and satisfactory level of income. The objectives of this paper will be to review the highlights of various research findings, to surface some overlooked factors in dealing with the region, and to dwell on the outlook for the region.
Closing the Racial Wealth Gap: Establishing and Sustaining an Initiative

By 2003, the savings and asset building field had achieved critical research and policy successes. However, some challenges it faced were the lack of a substantial presence of organizations of color in the field and the absence of experts of color at decision-making tables. Over the course of 11 years, a strategy was developed within the Ford Foundation to gain an understanding of the knowledge and perspective of communities of color about saving and wealth building and to then include this perspective within the asset building field. This article provides a social history of the work undertaken to create and sustain this initiative.
Reference aquaplanet climate in the Community Atmosphere Model, Version 5

In this study, fundamental characteristics of the aquaplanet climate simulated by the Community Atmosphere Model, Version 5.3 (CAM5.3) are presented. The assumptions and simplifications of the configuration are described. A 16 year long, perpetual equinox integration with prescribed SST using the model’s standard 18 grid spacing is presented as a reference simulation. Statistical analysis is presented that shows similar aquaplanet configurations can be run for about 2 years to obtain robust climatological structures, including global and zonal means, eddy statistics, and precipitation distributions. Such a simulation can be compared to the reference simulation to discern differences in the climate, including an assessment of confidence in the differences. To aid such comparisons, the reference simulation has been made available via earthsystemgrid.org. Examples are shown comparing the reference simulation with simulations from the CAM5 series that make different microphysical assumptions and use a different dynamical core.
Blood Values of Two American Carnivores

In the course of an investigation of the blood coagulation mechanism of a series of mammals, a male raccoon ( Procyon lotor ) and a female bear ( Euarctos americanus ) were presented to the author. The raccoon was captured twenty-four hours before studies were made, near Littlestown, Pennsylvania. The bear, a yearling weighing 21 kg., was captured approximately a week before the studies were made, in the Adirondack region of New York. Twenty-four mis. of blood were taken …
Time-Lapse Seismic Imaging by Linearized Joint Inversion – A Valhall Field Case Study

We present an application of linearized joint inversion to timelapse data sets from the Valhall field. By accounting for illumination mismatches—caused by differences in acquisition geometries—and for band-limited wave-propagation effects, our method provides more reliable estimates of productionrelated changes in reservoir properties than conventional timelapse imaging methods. Using subsets of the Valhall Life of Field Seismic data sets, we demonstrate how this method attenuates artifacts in time-lapse seismic images that are caused by data gaps due to obstructions.
Control of Three-dimensional Flow Instabilities at the Side-wall Junction of an Airfoil Cascade

Active flow control in the form of pulsed jets has been applied to the airfoil-sidewall junction of a cascade of low pressure turbine airfoils. The flow is characterized by a large streamwise vortex structure that interacts strongly with the airfoil suction surface boundary layer generating significant total pressure loss. Results from a previous study highlight a specific range of jet pulsing frequency that is highly effective at reducing generated losses through increased mixing. At this frequency, phase-locked stereo-PIV highlights differing dynamics as the vortex center moves due to the jet actuation. It is suggested that this behavior is due to an excited long-wavelength vortex instability that develops between the vortex and the strain applied by the neighboring walls. An inviscid vortex-line method for a vortex-corner interaction is developed that predicts the range of unstable frequencies and the expected dynamics of the instability. The unstable frequency range and expected dynamics are shown to agree very well. Finally, a simplified experiment is discussed with a generated vortex and a suspended wall. Stereo-PIV synchronized with a forcing subwoofer clearly extracts dynamics that suggest the development of a long-wavelength cooperative instability between the vortex and the wall. Future work on this facility will be used to inform the design of flow-control methods for secondary flows.
Impact of Milk Packaging Changes on Children's Milk Consumption

Children's declining milk consumption may be related to fewer opportunities to consume milk. Milk is offered with school meals, thus it is important to know how well children consume milk at school...
Study on Work Ability of Dust-exposed Workers

Objective To analyze the work ability variation of dust-exposed workers.Methods Work ability of 213 healthy workers with no dust exposure(control group) and 307 dust-exposed workers was assessed by 'Work Ability Index'(WAI) with questionaires.Results The mean level of WAI decreased with age in all groups.There was no significant difference in genders.The differences of WAI mean level between 3 groups were statistically significant(P0.01),in which,of control group was lower than that of dust-exposed workers,of dust-exposed workers was lower than that of pneumoconiosis patients(P0.01).There was no statistical difference between pneumoconiosis patients and the control.Conclusion It suggested that the work ability of dust-exposed workers had been decreased before pneumoconiosis developed.In order to protect the work ability and health of dust-exposed workers,measures should be taken early.
Abstract B22: BRCA1 and BRCA2 mutational spectra in African American men with prostate cancer

Introduction: Mutations in BRCA1/2 increase the risk of breast and ovarian cancer. Notably, in studies of Ashkenazi Jewish men, BRCA1/2 mutations have also been found to increase the risk of prostate cancer. Fortunately, for men and women with unequivocal BRCA1/2 mutations, treatment guidelines are available consequently leading to improved outcomes. Given the high incidence and mortality rates of prostate cancer (PCa) in African American men, we sought to determine impact, as well as the mutational spectra of BRCA1 and BRCA2 in African American men with hereditary prostate. Methods: For this study, DNA from PCa patients with and without a family history of breast (n=9) or ovarian (n=2) (OvCa) cancer were interrogated using targeted next generation sequencing of BRCA1 and BRCA2 coding region and exon-intron boundaries. Fifteen individual samples (mean age= 56.47 years; Range= 45-71 years) were sequenced along with a 16th sample which contained a pool of 25 individuals (mean age=59.17 years; Range=50-69 years) with no reported family history of breast or ovarian cancer. Results: Next generation sequencing results displayed 776,731 read with an average of 133 base pairs per read. There was a minimum coverage of 100x with an average of 250x; each sample averaged 13 variants. There were 205 (15.5%) heterozygous and homozygous variant calls for which 197 (96.1%) were SNPs and 8 (3.9%) were deletions. Specifically, 131 (63.9%) and 74 (36.1%) variants were found in BRCA2 and BRCA1, respectively. Of the 48 unique variants, 14 (29.2%) were found in exons. Importantly, 7 (46.67%) of the exonic variants, mainly rs766173, rs180426, rs144848, rs1799944, rs2227943, 37218874, and rs4986850, were differentially found in those with a family history of BCa or OvCa compared to those without. In particular, rs766173, rs180426, rs1799944, and rs37218874 variants were found in those who reported a family history of BCa or OvCa, although the frequencies were low. Of the 7 exonic variants, 2 were potentially damaging as determined by bioinformatics analysis, 3 were likely benign, and 2 were variants of unknown significance. However, none were unequivocally pathogenic. Conclusions: Like their African American breast cancer counterparts, the impact of BRCA1 and BRCA2 on prostate cancer remains unknown due to the high frequency of variants of unknown significance. Therefore, functional studies of these variants are warranted. The identification of genetic and molecular mechanisms associated with carcinogenesis will allow clinicians to personalize prevention, management, and treatment strategies. Citation Format: Cha9Tonya Brown, John McDonald, Muneer Abbas, Georgia Dunston, Yasmine Kanaan, Luisel Ricks-Santi. BRCA1 and BRCA2 mutational spectra in African American men with prostate cancer. [abstract]. In: Proceedings of the Eighth AACR Conference on The Science of Health Disparities in Racial/Ethnic Minorities and the Medically Underserved; Nov 13-16, 2015; Atlanta, GA. Philadelphia (PA): AACR; Cancer Epidemiol Biomarkers Prev 2016;25(3 Suppl):Abstract nr B22.
Bodily Protection: Dress, Health, and Anxiety in Colonial New England

In colonial America, as in many colonial contacts, human bodies were at the center of most discussions of self and others. In this paper, I explore how the disciplines of body, intellect, and soul were entangled at colonial Harvard College. Early Harvard was fashioned to be a bastion of Puritan ideology, where English and Native students were trained in “knowledge and godliness.” Adherence to this ideology was regulated through the production of College laws, modeled after the laws of the Massachusetts Bay Colony, regarding comportment, action, and dress of the students and tutors of the College. Colony and College laws underscore bodily anxieties that abounded in Puritan New England regarding the dangers of witchcraft, overt sumptuous behavior, and pleasures of the flesh. I ground my discussions in current theoretical perspectives on embodiment and materiality to explore how anxieties regarding one’s body impacted embodied practices relating to dress and protection of the physical and spiritual flesh. To what extent (if any) did Puritan notions of morality and health impact the lives and material culture of students living at seventeenth and early eighteenth-century Harvard?
Soft power and empire

“Soft power” refers to nations securing influence overseas by persuasion or attraction rather than by threats, military force, or economic sanctions. Historically, empires have varied in their use of and ability to rely on soft power. As a vehicle of influence it has most often been available to Great Powers driven by an inspiring political ideology, particularly when combined with an attractive culture, foreign investments, education, development aid, and non-threatening diplomacy. Soft power was crucial to the 19th-century British Empire. It also played a significant role for the United States, particularly after the end of World War II as the USA became the most powerful nation in the world. In recent years, Chinese foreign policy has also been driven by soft power principles as the People's Republic of China attempts to establish influence around the world. Keywords: Chinese soft power; imperial history; postcolonialism; power; soft power; United States soft power
UFT: East meets West in drug development.

Although the combination of uracil and tegafur (UFT) has been available commercially in Japan since 1984 and is one of the most extensively prescribed antineoplastic agents in that country, few physicians outside Japan have knowledge of and
Statistical analysis on findings in the quality management system during inspection of IVD manufactures of China

Objective To explore the current state and the mainly typical problems and vulnerable parts existed in the quality management systems (QMS) of local in vitro diagnostic reagent manufactures. Method To statistical analyze the problems found in the quality management system of in vitro diagnostic reagent manufactures through inspection organized by CCD, SFDA during the second half year of 2011. Results The total level of the QMS of local IVD manufacturers has risen greatly in past recent years, but a lot of problems still existed. The main vulnerable issues existed in QMS of IVD are documentation and recorder control, design control and validation, producing process control, as well as monitoring and quality control etc, to which should be paid more attention in the future improvement made by the enterprises and supervision by the administration authorities.
Practice Guidelines and the Industrialization of Behavioral Healthcare Delivery

This chapter discusses practice guidelines and the industrialization of behavioral healthcare delivery. It serves three main purposes. First, that practice guidelines are not an arbitrary development in the field. The logic in outline form can be that managed behavioral care marks the transition of this economic sector to full scale industrialization. Practice guidelines are a necessary component of an industrialized behavioral health care delivery system because they help ward off threats to successful industrialization. Second, practice guidelines hold out great hope for consumers, managers, payors, and providers alike, but only if they are properly done, with participation of all the major stakeholders. It also describes the practice guidelines coalition process as a good example of what needs to be done. The chapter concludes by discussing the practice guidelines fit within an integrated system of evidence-based care.
From Teacher Education to Practicing Teacher: What Does Culturally Relevant Praxis Look Like?:

Despite reports of already practicing K-12 teachers’ attempts to teach for critical social justice in their classrooms, there is little connection between teacher education programs and/or the impa...
The Toronto Temple

This chapter clarifies the ways in which the Adhiparasakthi temple mandram situates itself ritually within the context of diaspora Hinduism in Canada and takes a close look at some of its elements of distinction. While a number of contemporary Hindu guru-led organizations with transnational constituencies have tended to reduce and/or downplay ritual practices, the Adhiparasakthi organization has opted to expand and extend ritual practice and direct ritual participation to a wider demographic. One of the most prominent, defining elements of this goddess tradition is that women are privileged with positions of leadership and ritual authority. This represents an extraordinary shift from orthodox tradition in which religious authority has been the exclusive domain of male Brahmin priests.
“It’s 1000 Degrees in Here When I Teach”: Providing Preservice Teachers With an Extended Opportunity to Approximate Ambitious Instruction

Teacher educators have a challenging task of designing opportunities for preservice teachers (PSTs) to learn ambitious science teaching (AST). However, with limited time in methods courses and the ...
Phosphorus availability regulates intracellular nucleotides in marine eukaryotic phytoplankton

Marine eukaryotic phytoplankton adapt to low phosphorus (P) in the oceans through a variety of step-wise mechanisms including lipid substitution and decreased nucleic acid content. Here, we examined the impact of low P concentrations on intracellular metabolites whose abundances can be quickly adjusted by cellular regulation within laboratory cultures of three model phytoplankton and in field samples from the Atlantic and Pacific Oceans. We quantified the relative abundances of monophosphate nucleotides and their corresponding nucleosides, using a combination of targeted and untargeted metabolomics methods. Under P-deficient conditions, we observed a marked decrease in adenosine 5′-monophosphate (AMP) with a concomitant increase in adenosine. This shift occurred within all detected pairs of monophosphate nucleotides and nucleosides, and was consistent with previous work showing transcriptional changes in nucleotide synthesis and salvage under P-deficient conditions for model eukaryotes. In the field, we observed AMP-to-adenosine ratios that were similar to those in laboratory culture under P-deficient conditions.
Scheduling algorithms for rapid imaging using agile Cubesat constellations

Abstract Distributed Space Missions such as formation flight and constellations, are being recognized as important Earth Observation solutions to increase measurement samples over space and time. Cubesats are increasing in size (27U, ∼40 kg in development) with increasing capabilities to host imager payloads. Given the precise attitude control systems emerging in the commercial market, Cubesats now have the ability to slew and capture images within short notice. We propose a modular framework that combines orbital mechanics, attitude control and scheduling optimization to plan the time-varying, full-body orientation of agile Cubesats in a constellation such that they maximize the number of observed images and observation time, within the constraints of Cubesat hardware specifications. The attitude control strategy combines bang-bang and PD control, with constraints such as power consumption, response time, and stability factored into the optimality computations and a possible extension to PID control to account for disturbances. Schedule optimization is performed using dynamic programming with two levels of heuristics, verified and improved upon using mixed integer linear programming. The automated scheduler is expected to run on ground station resources and the resultant schedules uplinked to the satellites for execution, however it can be adapted for onboard scheduling, contingent on Cubesat hardware and software upgrades. The framework is generalizable over small steerable spacecraft, sensor specifications, imaging objectives and regions of interest, and is demonstrated using multiple 20 kg satellites in Low Earth Orbit for two case studies – rapid imaging of Landsat’s land and coastal images and extended imaging of global, warm water coral reefs. The proposed algorithm captures up to 161% more Landsat images than nadir-pointing sensors with the same field of view, on a 2-satellite constellation over a 12-h simulation. Integer programming was able to verify that optimality of the dynamic programming solution for single satellites was within 10%, and find up to 5% more optimal solutions. The optimality gap for constellations was found to be 22% at worst, but the dynamic programming schedules were found at nearly four orders of magnitude better computational speed than integer programming. The algorithm can include cloud cover predictions, ground downlink windows or any other spatial, temporal or angular constraints into the orbital module and be integrated into planning tools for agile constellations.
An Examination of Bullying and Physical Health Problems in Adolescence among South Korean Youth

The current study provides a longitudinal examination of the relationship between bullying victimization and adolescent physical health. Relying on data from a large sample of adolescents from South Korean schools (Korean Children and Youth Panel Survey), a series of ordinary least squares regression models were estimated for adverse physical health outcomes. The results suggest that bullying victimization and perpetration is a significant risk factor for various forms of adverse physical health outcomes including asthma, rhinitis, and obesity. Specifically, being the victim of verbal bullying was associated with greater exposure to adverse health problems, including asthma, rhinitis, and obesity. We also found that being bullied physically was associated with a higher prevalence of obesity but those effects dissipated in fully controlled models. Lastly, we did observe that verbal bullying perpetration was associated with more asthma over time. Study limitations and implications for bullying prevention are also discussed.
Peripheral Nerve Injury After Elbow Arthroscopy: An Analysis of Risk Factors

Purpose To identify risk factors associated with peripheral nerve injury after elbow arthroscopy and provide an updated incidence of those complications. Methods The elbow arthroscopies that were performed at our institution between 2006 and 2016 were identified. Over a 10-year period, 253 elbow arthroscopies were performed at our institution. Two hundred twenty-seven cases had a minimum follow-up of 4 weeks, and were included in our analysis. Minor and major nerve-related complications were recorded. The surgeon's experience and training, body max index of the patients, surgical tourniquet time, type of anesthesia or surgery, radiographic appearance of the elbow, diagnosis at the time of surgery, and presence of diabetes were analyzed. Results There were 12 reported peripheral nerve injuries, 10 minor (4.4%) and 2 major complications (0.9%). The risk factors examined in this study were not correlated with a higher rate of complications. Conclusions The minor nerve–related complication rate was 4.4%, with a 0.9% incidence of major peripheral nerve injury. Based on these findings, we conclude that elbow arthroscopy is a relatively safe procedure. The risk factors examined in this study had no association with the rate of complications. This finding could be potentially related to type II or beta error in the analysis of risk factors for nerve injury. The exact reasons for nerve injury are not known from this study. Level of Evidence Level IV, retrospective case series.
Hangover in Post-College-Aged Drinkers: Psychometric Properties of the Hangover Symptom Scale (HSS) and the Hangover Symptom Scale-Short Form (HSS-5).

BACKGROUND Alcohol hangovers have been found to be a common and costly consequence of alcohol misuse. However, there is only limited psychometric support for instruments to accurately measure hangovers beyond the college-age years. This study investigated the psychometric properties of the Hangover Symptom Scale (HSS) and the Hangover Symptom Scale-Short Form (HSS-5) including the internal consistency, convergent and discriminant validity, construct validity, and the measurement invariance of these scales between light and heavy drinkers, individuals with a positive and negative family history of alcohol use disorder (AUD), and men and women in a post-college-aged sample. The association of the HSS and HSS-5 with alcohol use problems was also tested. METHODS Participants were 294 nonalcoholic light and heavy social drinkers (age range 21 to 35 years; 57.8% male) enrolled in the Chicago Social Drinking Project. They completed the HSS as part of a take-home packet completed outside of the laboratory. The psychometric properties of the HSS and HSS-5 were tested. RESULTS Stronger psychometric support was found for the HSS-5 relative to the full HSS. While both measures demonstrated strong internal consistency reliability, convergent and discriminant validity, and an association with alcohol use problems, only the HSS-5 showed construct validity as determined by confirmatory factor analysis. Further, only the HSS-5 showed measurement invariance between men and women, light and heavy drinkers, and individuals with a positive and negative family history of AUD. CONCLUSIONS This was the first study to examine the psychometric properties of the HSS and HSS-5 in a post-college-aged sample and the first to investigate the measurement invariance of these measures as a function of sex, drinking history, and family history of AUD. This study supports the use of the HSS-5 as a reliable and valid brief measure of frequency of hangover symptoms.
The role of organizational size and industry in job quality and work-family relationships

In this study we update analyses of the 1977 QES (Zipp, 1991) using data from the 1997 National Study of the Changing Workforce. We use hierarchical linear modeling procedures to partition the variance in a wide variety of indicators of workers' experiences. Most variation was associated with the individual level of analysis, but significant and nontrivial variation also was associated with the organizational and industrial levels. Although workers in smaller organizations reported lower earnings, fewer benefits, and less education than their counterparts in larger organizations, they also reported experiencing less discrimination, better fit between their actual and desired work hours, more supportive work environments and loyalty to their employers, less burnout or interference between work and family, and shorter commute times.
Standing the Test of Time: Validating the TEDS-M Knowledge Assessment Against MET II Expectations

We report the results of a post hoc validation study in which publicly released TEDS-M knowledge assessment items for elementary teachers were validated against the specifications for teacher knowledge found in the Mathematical Education of Teachers II (MET II) report. The validation was based on the expert judgments of two authors of the MET II report. Raters reported a suitable match between specific MET II mathematical content and mathematical practice expectations for almost all TEDS-M items. Inter-rater agreement was very high regarding mathematical content expectations, but much lower for mathematical practices. Expert ratings indicated that TEDS-M released items mapped to some but not all MET II content domains. The findings suggest strong content validity for TEDS-M items in some respects though not in others.
The Media Event Build-Up Phase: A Site of Contestation and Counternarratives

The media events and sports mega-events literatures show that celebratory media narratives dominate or dismiss criticism of events like the Olympics. Given this bias, this article explores how critics of the Games contest official and celebratory narratives around the Olympic media event. Through document analysis and interviews, I examine two alternative media projects that built extensive critiques of the 2016 Rio Olympics. These projects not only criticized the urban and social impacts of the mega-event but also explicitly deconstructed the event’s official narratives, exposing the workings of the media event of which they themselves were coproducers. Contrary to the media event literature’s focus on the live phase of events, I argue that that the “build-up phase” is a crucial period for the development and contestation of narratives about the Olympic event model and the media structures that sustain it.
Environmental influences on RNA processing: Biochemical, molecular and genetic regulators of cellular response

RNA processing has emerged as a key mechanistic step in the regulation of the cellular response to environmental perturbation. Recent work has uncovered extensive remodeling of transcriptome composition upon environmental perturbation and linked the impacts of this molecular plasticity to health and disease outcomes. These isoform changes and their underlying mechanisms are varied-involving alternative sites of transcription initiation, alternative splicing, and alternative cleavage at the 3' end of the mRNA. The mechanisms and consequences of differential RNA processing have been characterized across a range of common environmental insults, including chemical stimuli, immune stimuli, heat stress, and cancer pathogenesis. In each case, there are perturbation-specific contributions of local (cis) regulatory elements or global (trans) factors and downstream consequences. Overall, it is clear that choices in isoform usage involve a balance between the usage of specific genetic elements (i.e., splice sites, polyadenylation sites) and the timing at which certain decisions are made (i.e., transcription elongation rate). Fine-tuned cellular responses to environmental perturbation are often dependent on the genetic makeup of the cell. Genetic analyses of interindividual variation in splicing have identified genetic effects on splicing that contribute to variation in complex traits. Finally, the increase in the number of tissue types and environmental conditions analyzed for RNA processing is paralleled by the need to develop appropriate analytical tools. The combination of large datasets, novel methods and conditions explored promises to provide a much greater understanding of the role of RNA processing response in human phenotypic variation. This article is categorized under: RNA Processing > RNA Editing and Modification RNA Evolution and Genomics > Computational Analyses of RNA RNA Processing > Splicing Mechanisms RNA Processing > Splicing Regulation/Alternative Splicing.
Calcium activation of silica surfaces with sodium oleate collector

In the Florida phosphate industry, fatty acid collectors are used to separate phosphate ore from silica during the rougher flotation stage. However, the presence of multivalent ions (in particular Ca++) in the processing water has been reported to result in the activation of silica with respect to oleate adsorption, rendering it floatable. Hence, adequate separation may not be achieved during the rougher flotation stage. In this study, the direct measurement of surface interaction forces via atomic force microscopy was used to delineate possible mechanisms for calcium activation under phosphate flotation conditions at oleate/calcium concentrations both above and below the calcium dioleate precipitation limit.