cssi/SciSciGPT-SciSciNet huggingface dataset:
Seismic Source Descriptions of Underground Explosions and a Depth Discriminate

Synthetic seismograms of both body waves and Rayleigh waves are used to determine the radiation field of a few large contained underground explosions. A number of possible source descriptions are investigated. A reduced displacement potential of the form, o(t) = o_0t^ξ exp(-ηt), fits the long- and short-period data. The source parameters appropriate for the Boxcar event are ξ = 0·5 and η = 0·15. Synthetic PL and Rayleigh waves are compared with observations from a number of different size events to determine the dependence of η on yield. The amplitude of the long period synthetic body wave responses at ranges greater than about 12° increases rapidly as the source depth is increased. Thus the difference in spectral properties of explosions and earthquakes can be largely explained by the depth effect. The theoretical ratio SP/LP, that is the short period divided by the long-period amplitude, is computed from 12 to 25° for the Johnson upper mantle model and the Boxcar source. A study of an earthquake which cannot be distinguished from an explosion using the m_b vs. M_s criterion is investigated by the SP/LP discriminate.
Genome-wide errant targeting by Hairy

Metazoan transcriptional repressors regulate chromatin through diverse histone modifications. Contributions of individual factors to the chromatin landscape in development is difficult to establish, as global surveys reflect multiple changes in regulators. Therefore, we studied the conserved Hairy/Enhancer of Split family repressor Hairy, analyzing histone marks and gene expression in Drosophila embryos. This long-range repressor mediates histone acetylation and methylation in large blocks, with highly context-specific effects on target genes. Most strikingly, Hairy exhibits biochemical activity on many loci that are uncoupled to changes in gene expression. Rather than representing inert binding sites, as suggested for many eukaryotic factors, many regions are targeted errantly by Hairy to modify the chromatin landscape. Our findings emphasize that identification of active cis-regulatory elements must extend beyond the survey of prototypical chromatin marks. We speculate that this errant activity may provide a path for creation of new regulatory elements, facilitating the evolution of novel transcriptional circuits.
Electronic Health Record Challenges, Workarounds, and Solutions Observed in Practices Integrating Behavioral Health and Primary Care

Purpose: This article describes the electronic health record (EHR)-related experiences of practices striving to integrate behavioral health and primary care using tailored, evidenced-based strategies from 2012 to 2014; and the challenges, workarounds and initial health information technology (HIT) solutions that emerged during implementation. Methods: This was an observational, cross-case comparative study of 11 diverse practices, including 8 primary care clinics and 3 community mental health centers focused on the implementation of integrated care. Practice characteristics (eg, practice ownership, federal designation, geographic area, provider composition, EHR system, and patient panel characteristics) were collected using a practice information survey and analyzed to report descriptive information. A multidisciplinary team used a grounded theory approach to analyze program documents, field notes from practice observation visits, online diaries, and semistructured interviews. Results: Eight primary care practices used a single EHR and 3 practices used 2 different EHRs, 1 to document behavioral health and 1 to document primary care information. Practices experienced common challenges with their EHRs9 capabilities to 1) document and track relevant behavioral health and physical health information, 2) support communication and coordination of care among integrated teams, and 3) exchange information with tablet devices and other EHRs. Practices developed workarounds in response to these challenges: double documentation and duplicate data entry, scanning and transporting documents, reliance on patient or clinician recall for inaccessible EHR information, and use of freestanding tracking systems. As practices gained experience with integration, they began to move beyond workarounds to more permanent HIT solutions ranging in complexity from customized EHR templates, EHR upgrades, and unified EHRs. Conclusion: Integrating behavioral health and primary care further burdens EHRs. Vendors, in cooperation with clinicians, should intentionally design EHR products that support integrated care delivery functions, such as data documentation and reporting to support tracking patients with emotional and behavioral problems over time and settings, integrated teams working from shared care plans, template-driven documentation for common behavioral health conditions such as depression, and improved registry functionality and interoperability. This work will require financial support and cooperative efforts among clinicians, EHR vendors, practice assistance organizations, regulators, standards setters, and workforce educators.
Predation and Developmental Studies of Euseius hibisci (Chant) (Acarina: Phytoseiidae) Feeding on Bemisia tabaci (Gennadius) (Homoptera: Aleyrodidae)

Euseius hibisci (Chant) (Phytoseiidae) preyed on Bemisia tabaci (Gennadius) (Aleyrodidae) on cotton in the laboratory and developed to the adult stage feeding on a mixture of eggs and first and second instars of B. tabaci with 75% survival. Adult longevity and fecundity were greater when fed eggs than when fed first or second instars of B. tabaci . An average of 4.5 B. tabaci eggs were consumed per adult female per day with a range of 0 to 18.4 eggs, but older whitefly eggs were less acceptable. Unfed mites in the controls did not oviposit. Longevity, fecundity, and the oviposition period of E. hibisci feeding on B. tabaci were lower than those of pollen-fed mites.
Toward an Adaptive Sampling Strategy to Understand the Sensitivity of Biogeochemical Province Boundaries to Climate Change

Toward an Adaptive Sampling Strategy to Understand the Sensitivity of Biogeochemical Province Boundaries to Climate Change Over the last three decades, extensive oceanographic surveys have been conducted to improve the understanding of large-scale circulation and biogeochemical cycles in the marine environment. The World Ocean Circulation Experiment, the Joint Global Ocean Flux and GEOTRACES programs, along with many other studies, demonstrate that microbial communities drive the biogeochemical cycling of the major elements (e.g., C, N, P, S) on our planet. The results of these studies indicate that marine microbes generate and recycle about half of the organic carbon produced on Earth and carry out all nitrogen fixation, ammonia oxidation, denitrification, sulfur reduction/oxidation, and mediate the distribution and speciation of bioactive metals within the oceans.
Effects of pH and salt concentration on the formation and properties of chitosan-cellulose nanocrystal polyelectrolyte-macroion complexes.

This study examines the effects of pH and salt concentration on the formation and properties of chitosan–cellulose nanocrystal (CNC) polyelectrolyte–macroion complexes (PMCs). The components’ pK values, determined by potentiometric titration, were 6.40 for chitosan and 2.46 for the CNCs. The turbidity of PMC particle suspensions was measured as a function of chitosan–CNC ratio, pH, and salt concentration. The maximum turbidity values in titrations of a chitosan solution with a CNC suspension and vice versa occurred at charge ratios of 0.47 ± 0.11 (SO3–/NH3+) and 1.16 ± 0.06 (NH3+/SO3–), respectively. A pH increase caused a turbidity decrease due to shrinking of the PMC particles upon changes in their components’ degrees of ionization. An increase in salt concentration caused a decrease in turbidity due to charge-screening-related shrinking of the PMC particles. The effects of pH and salt concentration on particle size were confirmed by scanning electron microscopy.
Unusual presentation of osteochondroma (Trevor's disease)

Osteochondromas are common benign tumors. They probably are developmental malformation rather than true neoplasm and are thought to originate within the periosteum and small cartilage nodule. They rarely develop in the joint. Trevor disease or dysplasia epiphysealis hemimelica (DEH) refers to intraarticular epiphyseal osteochondroma. DEH has an incidence of 1 in 1 million and is characterized by asymmetric overgrowth of cartilage. Though many cases of DEH are asymptomatic, but they may be troublesome when they cause mechanical and pressure symptoms depending on the size and location. We report a case of Trevor's disease of the knee in a 21-year-old male with mechanical obstruction.
Therapeutic Effects of High-dose Intravenous Immunoglobulin Combined with Dexamethasone on Children with Acute Severe Idiopathic Thrombocytopenic Purpura

Objective:To evaluate the effectiveness of high-dose immunoglobulin combined with dexamethasone,high-dose immunoglobulin,high-dose dexamethasoneand in children with acute severe idiopathic thrombocytopenic purpura(ITP).Methods:Sixty-six patients hospitalized with PLT≤25×109/L and phanero-tendency of hemorrhage were randomly divided into three groups(every group n=22).The group of combined treatment was intravenous-dripped with immunoglobulin 400 mg/(kg·d) for five days and 1.5 mg/(kg·d) of dexamethasone for five days,and after the five days was orally administrated with 2 mg/(kg·d) of prednisolone.The group of immunoglobulin was intravenously dripped with 400 mg/(kg·d) of immunoglobulin for five days.The group of dexamethasone was intravenously dripped with 1.5 mg/(kg·d) of dexamethasone for five days,and then orally with prednisolone 2 mg/(kg·d).Results:In the group of combined treatment,the group of immunoglobulin and the group of dexamethasone,the time of PLT≥50×109/L was(2.1±0.6) days,(3.1±0.6) days,(4.0±0.8) days respectively,and the statistically significant differences among the three groups were found(P0.05).The time of PLT≥100×109/L was(4.4±1.0) days,(5.6±1.3) days,(7.1±1.1) days respectively with a statistically significant difference among them(P0.05).The time of PLT up to the peak value was(10.1±1.2) days,(11.2±1.3) days,(13.5±1.9) days respectively and a statistically significant difference(P0.05) was found among them.The peak value of PLT was(267±85)×109/L,(253±74)×109/L,(223±72)×109/L respectively and there was no statistically significant difference found(P0.05).Conclusions:Intravenous drip of high-dose immunoglobulin combined dexamethasone is more rapidly than any medications in increasing the platelet count in children with acute severe ITP.
CO2 enabled process integration for the production of cellulosic ethanol using bionic liquids

There is a clear and unmet need for a robust and affordable biomass conversion technology that can process a wide range of biomass feedstocks and produce high yields of fermentable sugars and biofuels with minimal intervention between unit operations. The lower microbial toxicity of recently-developed renewable ionic liquids (ILs), or bionic liquids (BILs), helps overcome the challenges associated with the integration of pretreatment with enzymatic saccharification and microbial fermentation. However, the most effective BILs known to date for biomass pretreatment form extremely basic pH solutions in the presence of water, and therefore require neutralization before the pH range is acceptable for the enzymes and microbes used to complete the biomass conversion process. Neutralization using acids creates unwanted secondary effects that are problematic for efficient and cost-effective biorefinery operations using either continuous or batch modes. We demonstrate a novel approach that addresses these challenges through the use of gaseous carbon dioxide to reversibly control the pH mismatch. This approach enables the realization of an integrated biomass conversion process that eliminates the need for intermediate washing and/or separation steps. A preliminary technoeconomic analysis indicates that this integrated approach could reduce production costs by 50–65% compared to previous IL biomass conversion methods studied.
Chapter 13 – Implications of Nanotechnology safety of sensors on homeland security industries

This chapter presents an overview of nanosensors and nanotechnology, including nanosensor construction, six basic types of nanosensors, and six prerequisites for the optimum functioning of nanosensors. The chapter discusses the transformation of nanomaterials when exposed to the environment, followed by safety issues involving human exposure and environmental pathways such as lung, dermal, and intestinal ingestion. Finally, nanosensor utilization in the homeland security and infrastructure industries was discussed, which include radiation physics, delayed neutron activation analysis, terahertz imaging, biosensing, and chemical vapors. New instrument standards and test methods and data are also discussed.
Abstract LB-060: A novel target for genetic silencing of AXL mediates taxane resistance, invasion, and migration in uterine cancer

Objectives: We investigated the role of AXL expression in chemotherapy response in uterine papillary serous cancer, and sought to reverse chemoresistance through inactivation of AXL. Methods: In vitro cell viability (XTT) assays were performed to confirm response to chemotherapy in AN3CA (taxane sensitive) and ARK1 (taxane resistant) uterine cell lines. AXL knockdown by siRNA was performed with either a traditional transfection reagent (DharmaFECT) or with a novel serum-stable, cell-penetrating, endosomolytic amphipathic peptide delivery system (p5RHH). Following knockdown of AXL using siRNA and p5RHH, chemotherapy response was assessed by XTT assay and invasion and migration assays were performed. Cell viability assays were analyzed using multiple t-tests. P Citation Format: Marguerite Palisoul, Mai Nguyen, Hua Pan, Anne Lohrey, Samuel Wickline, Matthew Powell, David Mutch, Katherine Fuh. A novel target for genetic silencing of AXL mediates taxane resistance, invasion, and migration in uterine cancer. [abstract]. In: Proceedings of the 107th Annual Meeting of the American Association for Cancer Research; 2016 Apr 16-20; New Orleans, LA. Philadelphia (PA): AACR; Cancer Res 2016;76(14 Suppl):Abstract nr LB-060.
New silicones for electrical applications

As might tie expected from the title, the purpose of this paper is not to cover all possible phases of the use of silicones in electrical applications, but to describe a few of the “new” silicones which are available, or about to become available to the electrical industry.
Achievement in Basic Math Skills for Low Performing Students: A Study of Teachers' Affect and CAI.

AbstractResearch on computer-assisted instruction (CAI) has neglected the importance of the teachers’ influence. This study investigated the effects of math instruction (with and without CAI) and the influence of teachers’ personalities (rated positive and negative) on the achievement of 117 remedial math students. Analysis of posttest results showed that students who had positive teachers were significantly different from those in negative classes. Students who received CAI showed more improvement than those who did not, but to a lesser degree. The most effective combination is a positive teacher who uses CAI. As there were no interactive effects, the results indicate that the personality of the teacher is a major influence on student achievement, regardless of the method of instruction.
Social Support to Reduce Uncertainty in Childhood Cancer in South Texas: A Case Study

Purpose: To determine if supportive measures are found to be most helpful and feasible for families of children with cancer by obtaining in-depth perspectives of uncertainty and adaptation. Hypothe...
International Law and the Fight Against Bureaucratic Corruption in Africa

Corruption is one Africa's most intractable problems. The article critically analyzes the role that international law can play in helping African countries more effectively deal with corruption, especially that which concerns the bribery of the continent's public officials. International law can help African countries fight corruption by (1) providing them with additional legal mechanisms to locate and retrieve resources that have been corruptly obtained from African economies; (2) helping African countries locate and retrieve accused criminals from foreign jurisdictions; and (3) imposing legal constraints on multinational corporations that participate in international business transactions, including those carried out on or with the continent.
Spatial resource heterogeneity increases diversity and evolutionary potential

Spatial heterogeneity is believed to be an evolutionary driver of biodiversity. Variability in the distribution of resource patches can allow an environment to support a wider variety of phenotypes for selection to act upon at the ecosystem level, which may lead to more species. However, the generality of this principle has not been thoroughly tested, as the relevant adaptive dynamics occur on evolutionary timescales. We overcame this challenge by performing experiments on populations of digital organisms in the Avida Digital Evolution Platform, in which we investigated the impact of spatial resource heterogeneity on phenotypic diversity. Since an important benefit of diversity may be increased evolutionary potential, we also tracked the probability of a complex trait evolving in the context of various levels of spatial heterogeneity. We found that spatial entropy and phenotypic diversity have a strong positive correlation and this relationship is consistent across various spatial configurations. Diversity also increases evolutionary potential, but has a much smaller impact than other components of environmental composition. The most important of these components was the mean number of resources present in locations across the environment, likely owing to the importance of building blocks for the evolution of complex features. These results suggest that a general relationship exists between spatial heterogeneity and diversity, beyond the specific ecosystems and timescales in which it has previously been studied. By examining this relationship in the context of phenotypic evolution, we advance a mechanistic understanding of the resulting dynamics. Moreover, our results suggest that the likelihood of evolving various traits can be impacted by the spatial configuration of patches in which these traits are advantageous. These findings have implications for both evolutionary biology and evolutionary computation, as generating and maintaining diversity is critical to all forms of evolution.
Dance Students at a Two Year College: Making Sense of Their Academic, Cultural, and Social World.

ABSTRACTThis qualitative study investigated the lived experiences of six community college dance students. The theoretical framework of social cognitive career theory was used but was modified to i...
Ecological opportunity alters the timing and shape of adaptive radiation

The uneven distribution of diversity is a conspicuous phenomenon across the tree of life. Ecological opportunity is a prominent catalyst of adaptive radiation and therefore may alter patterns of diversification. We evaluated the distribution of shifts in diversification rates across the cichlid phylogeny and the distribution of major clades across phylogenetic space. We also tested if ecological opportunity influenced these patterns. Colonization-associated ecological opportunity altered the tempo and mode of diversification during the adaptive radiation of cichlid fishes. Clades that arose following colonization events diversified faster than other clades. Speciation rate shifts were nonrandomly distributed across the phylogeny such that they were disproportionally concentrated around nodes that corresponded with colonization events (i.e., of continents, river basins, or lakes). Young clades tend to expand faster than older clades; however, colonization-associated ecological opportunity accentuated this pattern. There was an interaction between clade age and ecological opportunity that explained the trajectory of clades through phylogenetic space over time. Our results indicate that ecological opportunities afforded by continental and ecosystem-scale colonization events explain the dramatic speciation rate heterogeneity and phylogenetic imbalance that arose during the evolutionary history of cichlid fishes.
Locating polyhedral objects from edge point data

A method is presented to locate a general polyhedron in space with six degrees of freedom. A light stripe sensor is assumed to be capable of providing three-dimensional data points on known edges of the polyhedron to within a known accuracy. A representation is found for all the ways three line segments of fixed length can fall between the edges of a polyhedron. This representation, called an edge interval, is used in a tree search to find the location of each data point to within an interval on the edge. The final location of the object is determined by a one-dimensional line search. The method is illustrated with simulated data from a unit tetrahedron and results from a computer implementation are presented. The tree search takes a negligible amount of time and the one-dimensional line search takes a small additional increment.
Alternatives to Testosterone Therapy: A Review.

Abstract Introduction Although testosterone therapy (TTh) is an effective treatment for hypogonadism, recent concerns regarding its safety have been raised. In 2015, the US Food and Drug Administration issued a warning about potential cardiovascular risks resulting from TTh. Fertility preservation is another reason to search for viable alternative therapies to conventional TTh, and in this review we evaluate the literature examining these alternatives. Aims To review the role and limitations of non-testosterone treatments for hypogonadism. Methods A literature search was conducted using PubMed to identify relevant studies examining medical and non-medical alternatives to TTh. Search terms included hypogonadism, testosterone replacement therapy, testosterone therapy, testosterone replacement alternatives, diet and exercise and testosterone, varicocele repair and testosterone, stress reduction and testosterone, and sleep apnea and testosterone. Main Outcome Measures Review of peer-reviewed literature. Results Medical therapies examined include human chorionic gonadotropins, aromatase inhibitors, and selective estrogen receptor modulators. Non-drug therapies that are reviewed include lifestyle modifications including diet and exercise, improvements in sleep, decreasing stress, and varicocele repair. The high prevalence of obesity and metabolic syndrome in the United States suggests that disease modification could represent a viable treatment approach for affected men with hypogonadism. Conclusions These alternatives to TTh can increase testosterone levels and should be considered before TTh. Lo EM, Rodriguez KM, Pastuszak AW, Khera M. Alternatives to Testosterone Therapy: A Review. Sex Med Rev 2018;6:106–113.
Anesthetic Management for Pediatric Oculoplastic Surgery

This chapter covers the fundamentals of anesthesia for pediatric oculoplastic surgery. We begin with preoperative assessment, patient preparation, and an expanded section on anesthetic risk. A review of intraoperative anesthetic techniques follows with emphasis on management of the routine and difficult airway. Pertinent intraoperative complications are also discussed here. The anesthetic management of common pediatric oculoplastic and orbital procedures is covered next, with an in-depth discussion of anesthetic considerations for major craniofacial procedures. The final section on the postoperative period examines nausea/vomiting, pain management, emergence delirium, and general discharge criteria. Even as the discipline of pediatric anesthesia becomes more subspecialized and technically advanced, basic preoperative evaluation and planning remain essential to the conduct of safe anesthesia. Particular attention must be directed to those infants and children with syndromes known to include the difficult airway. Throughout the perioperative period, continued communication between the anesthesiologist and surgeon maximizes the quality of patient care.
A Novel Gaussian Discriminant Analysis-based Computer Aided Diagnosis System for Screening Different Stages of Alzheimer's Disease

This study introduces a novel Gaussian discriminant analysis (GDA)-based computer aided diagnosis (CAD) system using structural magnetic resonance imaging (MRI) data uniquely as input for screening different stages of Alzheimers disease (AD) involving its prodromal stage of mild cognitive impairment (MCI) in relation to the cognitive normal control group (CN). Taking advantage of multiple modalities of biomarkers, over the past few years, several machine learning-based CAD approaches have been proposed to address this high-dimensional classification problem. This study presents a novel GDA-based CAD system on the basis of a tenfold cross validation and a held-out test data set. Subjects considered in this study included 187 CN, 301 MCI, and 131 AD subjects from the Alzheimers Disease Neuroimaging Initiative (ADNI) database. In the tenfold cross validation, the proposed system achieved an average F1 score of 97.20%, accuracy of 96.00%, sensitivity of 99.14%, and specificity of 88.67% for discriminating together the MCI and AD groups from the CN group; and an average F1 score of 79.82%, accuracy of 87.43%, sensitivity of 79.09%, and specificity of 91.25% for discriminating AD from MCI. By testing on the held-out test data, for discriminating MCI and AD from CN, an accuracy of 93.28%, a sensitivity of 98.78%, and a specificity of 81.08% were obtained. These results also show that by separating left and right hemispheres of the brain into two decisional spaces, and then combining their outputs, the GDA-based CAD system demonstrates a high potential for clinical application.
Real-Time Visualization of Active Species in a Single-Site Metal–Organic Framework Photocatalyst

In this work, we report a new single-site photocatalyst (Co-Ru-UIO-67(bpy)) based on a metal–organic framework platform with incorporated molecular photosensitizer and catalyst. We show that this catalyst not only demonstrates exceptional activity for light-driven H2 production but also can be recycled without loss of activity. Using the combination of optical transient absorption spectroscopy and in situ X-ray absorption spectroscopy, we not only captured the key CoI intermediate species formed after ultrafast charge transfer from the incorporated photosensitizer but also identified the rate-limiting step in the catalytic cycle, providing insight into the catalysis mechanism of these single-site metal–organic framework photocatalysts.
Derivation of WECC distributed PV system model parameters from quasi-static time-series distribution system simulations

The response of low voltage networks with high penetration of PV systems to transmission network faults will, in the future, determine the overall power system performance during certain hours of the year. The WECC distributed PV system model (PVD1) is designed to represent small-scale distribution-connected systems. Although default values are provided by WECC for the model parameters, tuning of those parameters seems to become important in order to accurately estimate the partial loss of distributed PV systems for bulk system studies. The objective of this paper is to describe a new methodology to determine the WECC distributed PV system (PVD1) model parameters and to derive parameter sets obtained for six distribution circuits of a Californian investor-owned utility with large amounts of distributed PV systems. The results indicate that the parameters for the partial loss of distributed PV systems may differ significantly from the default values provided by WECC.
Mineral Dissolution and Fine Migration Effect on Oil Recovery Factor by Low-Salinity Water Flooding in Low-Permeability Sandstone Reservoir

Abstract The latest oil price decline simply increases the demand for enhanced oil recovery (EOR) and pushes research developers to keep improvements in oil recovery. The goal is always to recover as much oil as possible at the lowest possible cost. Low-salinity water flooding (LSWF) is an EOR method that operates at a lower cost than other EOR methods. The objective of this study was to test the ability of low salinity waterflooding to improve oil recovery from low permeability sandstone reservoirs. Four types of tests were conducted: imbibition, core flooding, zeta potential and scanning electron microscopy (SEM) tests. Two key factors were studied: salinity of the injected water and aging time. Their influence on the amount of oil recovery, stabilized injection pressure, pH, and permeability reduction was determined. The results showed that injected low brine concentration resulted in improving oil recovery. The oil recovery factor results during the second water flooding cycle (after aging for 24 h) showed more oil recovered during low water salinity injections. The zeta potential results showed that decreasing the salinity of injected water resulted in a decrease of the zeta potential value for both injection cycles, before and after aging for 24 h. Results also imply Low-salinity water flooding redistributes the flowing paths by releasing sand particles and some fine minerals causing the flow path to narrow. Thus, low salinity water flooding can create a new streamline (fluid flow diversion) and improve both displacement and sweep efficiency.
Public Awareness of Uterine Power Morcellation Through US Food and Drug Administration Communications: Analysis of Google Trends Search Term Patterns.

Background: Uterine power morcellation, where the uterus is shred into smaller pieces, is a widely used technique for removal of uterine specimens in patients undergoing minimally invasive abdominal hysterectomy or myomectomy. Complications related to power morcellation of uterine specimens led to US Food and Drug Administration (FDA) communications in 2014 ultimately recommending against the use of power morcellation for women undergoing minimally invasive hysterectomy. Subsequently, practitioners drastically decreased the use of morcellation. Objective: We aimed to determine the effect of increased patient awareness on the decrease in use of the morcellator. Google Trends is a public tool that provides data on temporal patterns of search terms, and we correlated this data with the timing of the FDA communication. Methods: Weekly relative search volume (RSV) was obtained from Google Trends using the term “morcellation.” Higher RSV corresponds to increases in weekly search volume. Search volumes were divided into 3 groups: the 2 years prior to the FDA communication, a 1-year period following, and thereafter, with the distribution of the weekly RSV over the 3 periods tested using 1-way analysis of variance. Additionally, we analyzed the total number of websites containing the term “morcellation” over this time. Results: The mean RSV prior to the FDA communication was 12.0 (SD 15.8), with the RSV being 60.3 (SD 24.7) in the 1-year after and 19.3 (SD 5.2) thereafter (P<.001). The mean number of webpages containing the term “morcellation” in 2011 was 10,800, rising to 18,800 during 2014 and 36,200 in 2017. Conclusions: Google search activity about morcellation of uterine specimens increased significantly after the FDA communications. This trend indicates an increased public awareness regarding morcellation and its complications. More extensive preoperative counseling and alteration of surgical technique and clinician practice may be necessary. [JMIR Public Health Surveill 2018;4(2):e47]
Superconducting Critical Field Curves for Th—U

Maple and co-workers1 have presented strong evidence that the Th—U magnetic impurity system shows localized spin fluctuation (LSF) phenomena.2 The normal-state low-temperature electrical resistivity data for these alloys obey the ρ = ρ 0(l — T 2/T 2 0) law, where T 0 is approximately 100°K and the thermoelectric power goes through a maximum at about 80°K. In addition, the superconducting transition temperature vs. concentration curve, T c vs. n, shows positive curvature, as expected for LSF, and the effective moment determined from susceptibility data decreases rapidly with decreasing temperature below 100°K. All of these measurements point toward a localized spin fluctuation interpretation of the data.
RNA Recognition-like Motifs Activate a Mitogen-Activated Protein Kinase.

Smk1 is a mitogen-activated protein kinase (MAPK) family member in the yeast Saccharomyces cerevisiae that controls the postmeiotic program of spore formation. Ssp2 is a meiosis-specific protein th...
Case 3-2019: A 70-Year-Old Woman with Fever, Headache, and Progressive Encephalopathy.

A Woman with Fever, Headache, and Progressive Encephalopathy A 70-year-old woman with a history of migraines was admitted to the hospital in autumn because of fever, headache, and encephalopathy. M...
A One Year Retrospective on a MOOC in Parallel, Concurrent, and Distributed Programming in Java

Much progress has been made on integrating parallel programming into the core Computer Science curriculum of top-tier universities in the United States. For example, "COMP 322: Introduction to Parallel Programming" at Rice University is a required course for all undergraduate students pursuing a bachelors degree. It teaches a wide range of parallel programming paradigms, from task-parallel to SPMD to actor-based programming. However, courses like COMP 322 do little to support members of the Computer Science community that need to develop these skills but who are not currently enrolled in a four-year program with parallel programming in the curriculum. This group includes (1) working professionals, (2) students at USA universities without parallel programming courses, or (3) students in countries other than the USA without access to a parallel programming course. To serve these groups, Rice University launched the "Parallel, Concurrent, and Distributed Programming in Java" Coursera specialization on July 31, 2017. In 2017, the authors of that specialization also wrote an experiences paper about launching the specialization. In this paper, the sequel to our previous publication, we look back at the first year of the Coursera specialization. In particular, we ask the following questions: (1) how did our assumptions about the student body for this course hold up?, (2) how has the course changed since launch?, and (3) what can we learn about how students are progressing through the specialization from Coursera's built-in analytics?
Behind the Scenes: Course Syllabi explained

In this Full Research Paper, as part of a larger research project that sought to understand the experiences of assistant engineering professors at non-R1 institutions, I examined the teaching conceptions and methods that were described in participants’ course syllabi. The actual course syllabi documents were examined, and additionally, I examined the way the participants themselves described their course syllabi using an interviewing technique called document elicitation. In this paper, I present the findings for two participants who both taught a course on “Dynamic Systems and Controls.” This paper presents an exploratory content analysis of a course syllabus and the accompanying interviews about the course syllabus for two participants. I found that the instructors included a limited amount of information about their teaching conceptions and methods in their actual course syllabi documents. However, I found that the technique of document elicitation about course syllabi was extremely successful in getting a thick description about a participant’s teaching conceptions and methods. These findings point to the beneficial use of teaching syllabi in interviews and conversations about teaching as describing the backstory and decisions behind a course syllabus reveal much about instructors’ teaching conceptions and methods.
How do ecological resilience metrics relate to community stability and collapse

Abstract The concept of ecological resilience (the amount of disturbance a system can absorb before collapsing and reorganizing) holds potential for predicting community change and collapse—increasingly common issues in the Anthropocene. Yet neither the predictions nor metrics of resilience have received rigorous testing. The cross-scale resilience model, a leading operationalization of resilience, proposes resilience can be quantified by the combination of diversity and redundancy of functions performed by species operating at different scales. Here, we use 48 years of sub-continental avian community data aggregated at multiple spatial scales to calculate resilience metrics derived from the cross-scale resilience model (i.e., cross-scale diversity, cross-scale redundancy, within-scale redundancy, and number of body mass aggregations) and test core predictions inherent to community persistence and change. Specifically, we ask how cross-scale resilience metrics relate community stability and collapse. We found low mean cross-correlation between species richness and cross-scale resilience metrics. Resilience metrics constrained the magnitude of community fluctuations over time (mean species turnover), but resilience metrics but did not influence variability of community fluctuations (variance in turnover). We show shifts in resilience metrics closely predict community collapse: shifts in cross-scale redundancy preceded abrupt changes in community composition, and shifts in cross-scale diversity synchronized with abrupt changes in community composition. However, we found resilience metrics only weakly relate to maintenance of particular species assemblages over time. Our results distinguish ecological resilience from ecological stability and allied concepts such as elasticity and resistance: we show communities may fluctuate widely yet still be resilient. Our findings also differentiate the roles of functional redundancy and diversity as metrics of resilience and reemphasize the importance of considering resilience metrics from a multivariate perspective. Finally, we support the contention that ecological stability is nested within ecological resilience: stability predicts the behavior of systems within an ecological regime, and resilience predicts the maintenance of regimes and behavior of systems collapsing into alternative regimes.
Topological characterizations of amenability and congeniality of bases

We provide topological interpretations of the recently introduced notions of amenability and congeniality of bases of innite dimensional algebras. In order not to restrict our attention only to the countable dimension case, the uniformity of the topologies involved is analyzed and therefore the pertinent ideas about uniform topological spaces are surveyed. A basis B over an innite dimensional F-algebra A is called amenable if F B , the direct product indexed by B of copies of the eld F, can be made into an A-module in a natural way. (Mutual) congeniality is a relation that serves to identify cases when different amenable bases yield isomorphic A-modules. (Not necessarily mutual) congeniality between amenable bases yields an epimorphism of the modules they induce. We prove that this epimorphism is one-to-one only if the congeniality is mutual, thus establishing a precise distinction between the two notions.
Piezoelectric CMOS Charger: Highest Output-Power Design

Wireless microsensors and internet of things that add intelligence to the surroundings need ambient energy to extend life and expand functionality. Piezoelectric transducer can turn vibrations into electrical charge, and with the recycling bridge power stage, it can keep the highest voltage across the transducer and output the most power into the battery. This paper examines how to design the optimum recycling bridge power stage. Specifically, this paper theorizes the optimum size of the switches, the optimum inductor, and how to operate the circuit so that it losses the least power. The ohmic loss should equal charge loss to yield the lowest total loss on a MOSFET switch. The loss on the switches and the inductor are co-optimized. The switched inductor charger is optimized for discontinuous conduction mode. The resulting optimized power stage is 92% efficient.
Designing for Generative Online Learning: A Situative Program of Research

This chapter describes an interdisciplinary program of research on generative (i.e., readily transferable) online learning. We present productive disciplinary engagement and expansive framing as learning tools to understand and explain how students use their own unique experiences and positioning to frame curricula and engage with content. This is important because it can support generative learning that is most likely to transfer readily to a wide range of subsequent educational, professional, and personal contexts. Instructional designers and researchers alike should find this approach informative and potentially transformative.
Reproductive Health in IBD Patients

Many patients with inflammatory bowel disease (IBD) are diagnosed in early adulthood, impacting their reproductive health. We discuss the recent data related to fertility, preconception counseling, the safety of IBD medications during pregnancy and lactation, delivery methods, and postpartum care in women with IBD. Additionally, we will review the psychosocial aspects, the effect of IBD, and its treatment on sexual function (SD) and fertility in men. We address the misconceptions around these topics and help the healthcare providers (HCPs) manage these patients appropriately. HCPs play a crucial role in educating their patients about fertility, preconception care, efficacy, and safety of IBD therapies during pregnancy and breastfeeding. The pregnancy outcome improves significantly when the mother has been in remission for 3–6 months before conception. Most IBD therapies are safe during pregnancy and lactation. Reproductive health in men with IBD is often neglected. SD and infertility must be addressed in women and men to achieve the best outcome. Preconception counseling is essential to address reproductive issues in both women and men with IBD. During pregnancy, our main goal is to keep the mother in remission while avoiding adverse effects on the fetus. A multidisciplinary team approach is ideal to improve pregnancy outcomes through collaboration and shared decision-making.
Characterizing the arrhythmogenic substrate in personalized models of atrial fibrillation: sensitivity to mesh resolution and pacing protocol in AF models.

Aims Computationally guided persistent atrial fibrillation (PsAF) ablation has emerged as an alternative to conventional treatment planning. To make this approach scalable, computational cost and the time required to conduct simulations must be minimized while maintaining predictive accuracy. Here, we assess the sensitivity of the process to finite-element mesh resolution. We also compare methods for pacing site distribution used to evaluate inducibility arrhythmia sustained by re-entrant drivers (RDs). Methods and results Simulations were conducted in low- and high-resolution models (average edge lengths: 400/350 µm) reconstructed from PsAF patients' late gadolinium enhancement magnetic resonance imaging scans. Pacing was simulated from 80 sites to assess RD inducibility. When pacing from the same site led to different outcomes in low-/high-resolution models, we characterized divergence dynamics by analysing dissimilarity index over time. Pacing site selection schemes prioritizing even spatial distribution and proximity to fibrotic tissue were evaluated. There were no RD sites observed in low-resolution models but not high-resolution models, or vice versa. Dissimilarity index analysis suggested that differences in simulation outcome arising from differences in discretization were the result of isolated conduction block incidents in one model but not the other; this never led to RD sites unique to one mesh resolution. Pacing site selection based on fibrosis proximity led to the best observed trade-off between number of stimulation locations and predictive accuracy. Conclusion Simulations conducted in meshes with 400 µm average edge length and ∼40 pacing sites proximal to fibrosis are sufficient to reveal the most comprehensive possible list of RD sites, given feasibility constraints.
Confronting Stressors in the Therapy Room: Emergent Life Events in a Multiple Evidence-Based Practice Implementation Context

Life stressors, or emergent life events, have the potential to interfere with child and family therapy processes and have been cited as barriers to implementing evidence-based practices (EBPs) for ...
New bounds on guarding problems for orthogonal polygons in the plane using vertex guards with halfplane vision

Abstract Given a set F of k disjoint monotone orthogonal polygons with a total of m vertices, we present bounds on the number of vertex guards required to guard the free space and the boundaries of the polygons in F when the range of vision of each guard is bounded by 180∘ (the region in front of the guard). When the orthogonal polygons are axis aligned we prove that m 2 + ⌊ k 4 ⌋ + 4 vertex guards are always sufficient. When the orthogonal polygons are arbitrary oriented, we show that m 2 + k + 1 vertex guards are sometimes necessary and conjecture the bound is tight.
Urban high school students’ perceptions of race, gender, and benefits from participating in a STEMM pipeline programme: a sociocultural case study

Motivated by lack of diversity in Science Technology Engineering Mathematics and Medicine (STEMM) professions, this case-study explores a group of 25 high achieving, low SES, mostly female, majorit...
Effects of extended high frequency bandwidth in osseointegrated bone conduction device users.

Abstract High-frequency hearing above 5000 Hz improves the detection and discrimination of high frequency phonemes. Improved access to high-frequency hearing may be particularly advantageous in unilaterally deafened listeners who experience reduced access to high frequency speech cues on their impaired side and decreased speech perception abilities in competing noise. This study aimed to investigate the effects of extended high-frequency bandwidth on speech perception in unilaterally deafened osseointegrated bone conduction hearing device recipients. To study the effect of extended high-frequency bandwidth, participants underwent aided testing in narrow bandwidth and extended high-frquency bandwidth BCD listening conditions. Aided word and phoneme recognition in quiet was assessed at soft and conversational speech levels with the better ear plugged. Aided thresholds and Ling 6 phoneme sounds were also assessed in quiet with the better ear plugged. Speech perception in noise was assessed at ± 90° and co-located at 0° using the adaptive Hearing in Noise Test. Findings demonstrate a significant improvement in speech perception outcomes when listening with extended high-frequency bandwidth. Extended high-frequency bandwidth significantly improved word and phoneme recognition for soft and average conversational speech. The largest effects were observed for voiceless phonemes. Results suggest use of bone conduction devices with extended high-frequency bandwidth result in improved hearing outcomes when compared with narrow bandwidth bone conduction devices.
The Generation of Convex Sets—Convex Hulls

In this chapter a new operation—comparable in importance to the interior and closure operations—is introduced. It operates on each set S to produce a convex set—the convex hull of S—acting as a veritable machine for the generation of convex sets. In effect it expands an arbitrary set into a convex set in the simplest possible way.