cssi/SciSciGPT-SciSciNet huggingface dataset:
Arousal and upper airway resistance (UAR)

Objective: The objective of this study is to investigate upper airway resistance (UAR) in infants and children and presence/absence of electroencephalogram (EEG) arousal. Methods: Polysomnography with nasal cannula/pressure transducer and esophageal manometry; pattern recognition of sleep disordered breathing (SDB) in children. Identification of visually scored arousals in response to SDB. Power spectrum analysis of EEG associated with SDB. Results: Several breathing patterns and change in heart rate (HR) can be seen with abnormal UAR during sleep. SDB may end with or without visual arousal. Power spectrum analysis shows different EEG patterns with termination of UAR and SDB. HR is also variably modified. Conclusions: Airway reopening and decline in UAR is associated with variable central nervous system activation and only intermittently with arousals. q 2002 Elsevier Science B.V. All rights reserved.
Identification of Target Messenger RNA Substrates for the Murine Deleted in Azoospermia-Like RNA-Binding Protein

The murine autosomal deleted in azoospermia-like protein (mDAZL) is a germ cell-restricted RNA-binding protein essential for sperm production. Homozygous disruption of the mDAZL gene results in the absence of germ cells beyond the spermatogonial stage. Progress into the function of DAZL in spermatogenesis has been hampered without identification of the cognate mRNA substrates that it binds to and regulates. Using the isolation of specific nucleic acids associated with proteins (SNAAP) technique recently developed in our lab, we identified mRNAs from testis that were specifically bound by mDAZL. One mRNA encoded the Tpx-1 protein, a testicular cell adhesion protein essential for the progression of spermatogenesis. A 26-nucleotide region necessary and sufficient to bind mDAZL was found within additional mRNAs isolated by the screen. These included mRNA encoding Pam, a protein associated with myc; GRSF1, an mRNA-binding protein involved in translation activation, and TRF2, a TATA box-binding protein-like protein involved in transcriptional regulation. Each mRNA containing the mDAZL binding site was specifically bound by mDAZL. A similar sequence is also present in the Cdc25A mRNA, a threonine/tyrosine phosphatase involved in cell cycle progression. The mDAZL and Cdc25A homologues are functionally linked in Drosophila and are necessary for spermatogenesis. Our demonstration that Tpx-1 and Cdc25A mRNAs are bound by mDAZL suggests that mDAZL regulates a subset of mRNAs necessary for germ cell development and cell cycle progression. Understanding how mDAZL regulates the target mRNAs will provide new insights into spermatogenesis, strategies for therapeutic intervention in azoospermic patients, and novel approaches for male contraception.
Monte-Carlo Analysis of the Ge(Li) Detector Used in the Sum-Coincidence Mode

A Monte-Carlo model for investigating sequential gamma scattering and for predicting sum-coincidence and sum-only detector performance has been developed in order to assess the Compton suppression capabilities of Ge(Li) detectors which accept only multiple gamma interaction sequences. Calculated performance for a concentric cylindrical detector shows good agreement with experimentally observed sum-coincidence spectrometer (SCS) behavior. Calculations were made for hypothetical germanium detectors of cylindrical volumes from 7. 1 cc. to 28.3 cc., and for gamma energies of 320 keV to 2754 keV. The requirement of multiple scattering is shown to eliminate only a minor portion of the total-energy gamma events. Effects of detector volume are characterized, and the location and thickness of dead layers separating active detector regions are shown to be important to SCS performance. Calculations of the energy partitioning between detector volumes for coincidence events indicate that the "backscattering" mode is not the dominent mechanism for good event sequences as has been postulated, and that good and bad event sequences are highly localized on the two-parameter spectrum of the energy output from each detector for coincidence events. The relationship of the calculations to detector performance is given.
Regulating the Timing of CENP-A Nucleosome Assembly by Phosphorylation

In this issue of Developmental Cell, Yu et al. (2015) demonstrate that CENP-A phosphorylation by CDK1 inhibits its association with the chaperone protein HJURP and that the removal of this modification at mitotic exit is a key regulatory event that controls the timing of new CENP-A nucleosome formation at centromeres.
Fluxless Bonding of Large Silicon Chips to Ceramic Packages Using Electroplated Eutectic Au/Sn/Au Structures

A fluxless process of bonding large silicon chips to ceramic packages has been developed using a Au-Sn eutectic solder. The solder was initially electroplated in the form of a Au/Sn/Au multilayer structure on a ceramic package and reflowed at 430°C for 10 min to achieve a uniform eutectic 80Au-20Sn composition. A 9 mm × 9 mm silicon chip deposited with Cr/Au dual layers was then bonded to the ceramic package at 320°C for 3 min. The reflow and bonding processes were performed in a 50-mTorr vacuum to suppress oxidation. Therefore, no flux was used. Even without any flux, high-quality joints were produced. Microstructure and composition of the joints were studied using scanning electron microscopy with energy-dispersive x-ray spectro- scopy. Scanning acoustic microscopy was used to verify the joint quality over the entire bonding area. To employ the x-ray diffraction method, samples were made by reflowing the Au/Sn/Au structure plated on a package. This was followed by a bonding process, without a Si chip, so that x-rays could scan the solder surface. Joints exhibited a typical eutectic structure and consisted of (Au,Ni)Sn and (Au,Ni)5Sn phases. This novel fluxless bonding method can be applied to packaging of a variety of devices on ceramic packages. Its fluxless nature is particularly valuable for packaging devices that cannot be exposed to flux such as sensors, optical devices, medical devices, and laser diodes.
Women, violence with intimates, and substance abuse: relevant theory, empirical findings, and recommendations for future research

Evidence from the disparate domains of anthropology, criminology, psychology, and sociology indicates that women are involved in many of the same acts of aggression and violence as men, and that substance use may play an important role in these acts. Yet little is known of the pathways between violence and drugs for women. The aims of this paper are threefold: 1) To review and integrate existing literature addressing female violence and substance abuse, presenting available epidemiology, theories, and research applicable to the study of this problem. 2) To examine the political and methodological obstacles to conducting systematic research on female aggressiveness. 3) To offer recommendations for future epidemiological, preventive, and therapeutic research efforts in this vital yet grossly understudied area.
Does Personality Provide Unique Explanations for Behaviour? Personality as Cross-Person Variability in General Principles

I propose that personality does not provide unique explanations for human behaviour. Two principles, accessibility as a ‘cognitive’ principle and regulatory focus as a ‘motivational’ principle, are used to illustrate how personality can be reconceptualized as a cross-person source of variability in the functioning of general psychological principles that have situational sources of variability as well. For each of these principles, evidence is presented that ‘persons’ and ‘situations’ as sources of variability have similar eAects. I then provide some other examples of psychological principles having similar eAects when either persons or situations are the source of variability. I discuss the utility of a ‘general principles’ perspective for understanding the many ways that persons, groups, and situations can contribute to manifesting the same pattern of principles, and how some patterns are more adaptive than others. The implications of there being multiple ways of manifesting the same pattern are then considered for the classic issues of when personality is revealed and what is its range of applicability. Copyright # 2000 John Wiley & Sons, Ltd.
The effect of graft stiffness on knee joint biomechanics after ACL reconstruction--a 3D computational simulation.

Abstract Objective . The objective was to determine the effect of varying graft stiffness and initial graft tension on knee kinematics and graft tension after anterior cruciate ligament reconstruction. Design. A 3D computational knee model was used. Background. Many factors influencing the biomechanical outcome of anterior cruciate ligament reconstruction have been investigated. However, there are no reports on the effect of variations in graft stiffness on knee behavior. Methods. A 3D computational knee model was used to simulate anterior cruciate ligament reconstruction using three different grafts with stiffnesses similar to the anterior cruciate ligament (graft 1), a 10mm bone-patellar tendon-bone graft (graft 2), and a 14mm bone-patellar tendon-bone graft (graft 3). The initial graft tension was set to 0 or 40 N with the knee at 30° of flexion. A 134 N anterior tibial drawer load and a 400 N quadriceps load were applied to the knee, and kinematics and graft tension were calculated. Results. When fixed with no initial tension, graft 1 was found to under-constrain the knee, while graft 2 slightly over-constrained the knee, and graft 3 over-constrained the knee when compared to the intact knee. When an initial graft tension of 40 N was used, all of the reconstructed knees were more constrained than when an initial tension of 0 N was used. Conclusions. This study suggests that graft stiffness has a direct impact on knee biomechanics after anterior cruciate ligament reconstruction. An optimal anterior cruciate ligament reconstruction can be achieved if the anterior cruciate ligament is replaced by a graft with similar structural stiffness. Relevance This study showed that if the graft material and fixation sites are selected such that the anterior cruciate ligament structural stiffness is retained, normal knee kinematics can be restored.
Bubble behavior during solidification in low gravity

The trapping and behavior of gas bubbles were studied during low gravity solidification of carbon tetrabromide. The flight experiments were performed during two sounding rocket flights (SPAR 1 and SPAR 3) and involved gradient freeze solidification of gas saturated melts. Gas bubbles were evolved at the solid-liquid interfaces during the low gravity intervals. No large-scale thermal migration of bubbles, bubble pushing by the solid-liquid interface, or bubble detachment from the interface were observed during the low gravity experiments. During the SPAR 3 experiment, a unique bubble motion-fluid flow event occurred in one specimen: a large bubble moved downward and caused some circulation of the melt. The gas bubbles that were trapped by the solid in commercial purity material formed voids that had a cyclindrical shape in SPAR 3, in contrast to the spherical shape that had been observed in SPAR 1. These shapes were not influenced by the gravity level, but were dependent upon the initial temperature gradient. In higher purity material the shape of the voids changed from cylindrical in one-g to spherical in low-g.
LABORATORY CULTURE, GROWTH RATE, AND FEEDING BEHAVIOR OF A PLANKTONIC MARINE COPEPOD1

Rhincalunus nusutus was cultured through seven consecutive generations in 19-liter carboys when provided with a mixture of diatoms and Artcnzia salina nauplii as food. The mean generation length was 8.7 weeks, similar to that of the local field population of this species during some seasons. Fecundity of laboratory-reared animals was lower than that of the field population. Instantaneous coefficients of individual exponential growth ( k in the expression, Wt = Woekt,where W is body weight of organic carbon and t is days) were 0.24 to 0.12/day, depending on the age of the individual. About 10 pg of detrital carbon were produced as exuviae during the growth of an individual. Even young nauplii fed preferentially on large food particles. The suggestion that the copepods' first antennae are used in the feeding process was not supported by an experimental test. R. nusutus nauplii are apparently active enough to avoid being eaten by their parents.
Identification of a Male-Produced Aggregation Pheromone for Monochamus scutellatus scutellatus and an Attractant for the Congener Monochamus notatus (Coleoptera: Cerambycidae)

We report identification and field testing of 2-(undecyloxy)-ethanol (monochamol) as a sex-specific, aggregation pheromone component produced by males of Monochamus scutellatus scutellatus (Say) (Coleoptera: Cerambycidae), a longhorned beetle native to North America. A congener, Monochamus notatus (Drury), which uses the same hosts as M. s. scutellatus, also was attracted to this compound in field trials, suggesting it may be a pheromone component for this species as well. Panel traps were deployed along transects at each of five field sites in May 2010 to test attraction of native beetle species to a suite of cerambycid pheromone components, including monochamol, 3-hydroxyhexan-2-one, (2R*,3R*)- and (2R*, 3S*)-2,3-hexanediol, racemic (E/Z)-fuscumol, and (E/Z)-fuscumol acetate. In total, 209 adult M. s. scutellatus (136 females, 73 males) and 20 M. notatus (16 females, four males) were captured, of which 86 and 70%, respectively, were captured in traps baited with monochamol (means significantly different). Analysis of headspace volatiles from adult M. s. scutellatus by coupled gas chromatography-mass spectrometry and gas chromatography-electroantennogram detection confirmed that monochamol was produced only by males. Monochamol was not found in headspace extracts from adult M. notatus. This study provides further evidence that monochamol is a pheromone component common to several species in the genus Monochamus. The pheromone component should prove useful for monitoring native species for management purposes or conservation efforts, and for quarantine monitoring for exotic species.
Psychological Distress and Susceptibility to Cardiovascular Disease Across the Lifespan: Implications for Future Research and Clinical Practice.

Stress and psychological distress are known powerful, modifiable risk factors for cardiovascular disease (CVD) [(1–5)][1], yet we know little about when or how the processes underlying this relationship begin. Indeed, prospective lifespan research that connects childhood experience with subsequent
Paf1p, an RNA polymerase II-associated factor in Saccharomyces cerevisiae, may have both positive and negative roles in transcription

Regulated transcription initiation requires, in addition to RNA polymerase II and the general transcription factors, accessory factors termed mediators or adapters. We have used affinity chromatography to identify a collection of factors that associate with Saccharomyces cerevisiae RNA polymerase II (P. A. Wade, W. Werel, R. C. Fentzke, N. E. Thompson, J. F. Leykam, R. R. Burgess, J. A. Jaehning, and Z. F. Burton, submitted for publication). Here we report identification and characterization of a gene encoding one of these factors, PAF1 (for RNA polymerase-associated factor 1). PAF1 encodes a novel, highly charged protein of 445 amino acids. Disruption of PAF1 in S. cerevisiae leads to pleiotropic phenotypic traits, including slow growth, temperature sensitivity, and abnormal cell morphology. Consistent with a possible role in transcription, Paf1p is localized to the nucleus. By comparing the abundances of many yeast transcripts in isogenic wild-type and paf1 mutant strains, we have identified genes whose expression is affected by PAF1. In particular, disruption of PAF1 decreases the induction of the galactose-regulated genes three- to fivefold. In contrast, the transcript level of MAK16, an essential gene involved in cell cycle regulation, is greatly increased in the paf1 mutant strain. Paf1p may therefore be required for both positive and negative regulation of subsets of yeast genes. Like Paf1p, the GAL11 gene product is found associated with RNA polymerase II and is required for regulated expression of many yeast genes including those controlled by galactose. We have found that a gal11 paf1 double mutant has a much more severe growth defect than either of the single mutants, indicating that these two proteins may function in parallel pathways to communicate signals from regulatory factors to RNA polymerase II.
Hemodynamic and Energy Cost Responses to Changes in Arm Exercise Technique

The purpose of this investigation was to determine heart rate, blood pressure, rate pressure product, and oxygen consumption responses to variations in arm exercise technique of a specific calisthenics for cardiac rehabilitation. Eight subjects performed the following four variations of an arm calisthenics: slow paused, slow continuous, fast paused, and fast continuous. Heart rate, blood pressure, and metabolic cost were measured during the last minute of each variation. An analysis of variance revealed significant differences between exercise variations (p less than .05) across means in heart rate, blood pressure, rate pressure product, and metabolic equivalent terms. Post hoc analysis revealed that changes in technique caused significantly large differences (p less than .05) in heart rate, blood pressure, and rate pressure product, but metabolic equivalent term levels did not change significantly. Changes in arm exercise technique result in significant changes in heart rate, blood pressure, and rate pressure product with little or no changes in metabolic equivalent terms. This finding suggests that prescribing exercise based on metabolic equivalent terms may not be indicative of cardiac stress unless the technique of exercise is carefully monitored and controlled.
Computer Adoption Decision—Implications for Research and Extension: The Case of Texas Rice Producers

This study identifies the characteristics of Texas rice producers who have adopted computers relative to nonadopters. Primary survey data obtained in the spring of 1990 was examined using logit adoption. Thirty–seven percent of the respondents use computers in their business. The results indicate that as farm size and business complexity increase so does the probability of computer adoption. Some evidence that the adoption of computer technology differs from production technology surfaced. Producers' decisions to adopt a computer are associated with the actions of their peers and family. Encouraging computer user groups and computer training courses for producers could encourage the adoption of computer technology.
Intra-cerebral and intra-nasal melanocortin-4 receptor antagonist blocks withdrawal hyperalgesia in alcohol-dependent rats.

Humans diagnosed with alcohol use disorder are more sensitive to painful stimuli during withdrawal, which suggests that excessive alcohol drinking worsens pain outcomes. Alcohol-dependent rats exhibit increases in nociceptive sensitivity during withdrawal. Data from animal models suggest that brain melanocortin-4 receptors (MC4Rs) mediate alcohol drinking and nociception. Here we tested: (1) the effect of alcohol dependence on thermal nociception in rats, and (2) the ability of acute alcohol and (3) MC4R antagonists to reverse hyperalgesia during withdrawal in alcohol-dependent rats. Rats were trained to self-administer operant alcohol and were tested for baseline thermal nociception. Half of the rats were made dependent on alcohol, then all rats were cannulated in the lateral ventricle. We tested the effects of acute alcohol drinking, acute fixed-dose alcohol, intra-ventricular agouti-related protein (endogenous MC4R antagonist), intra-ventricular HS014 (synthetic MC4R antagonist) and intra-nasal HS014 on hyperalgesia during withdrawal in alcohol-dependent rats, relative to non-dependent drinkers and alcohol-naive controls. Alcohol-dependent rats exhibit thermal hyperalgesia that is abolished by alcohol drinking, bolus alcohol and intra-ventricular and intra-nasal MC4R antagonists. These manipulations did not affect thermal nociception in non-dependent drinkers and alcohol-naive controls, suggesting that alcohol dependence produces neuroadaptations in brain MC4R systems. These results suggest that brain MC4R systems may be an effective therapeutic target for reducing nociception in the alcohol-dependent organism.
On Self Tuning RegulatorsReceived 2 March 1972; revised 12 September 1972. The original version of this paper was presented at the 5th IFAC Congress which was held in Paris. France during lune 1972. It was recommended for publication in revised form by Associate Editor A. Sage.

Control laws obtained by combining a least squares parameter estimator and a minimum variance strategy based on the estimated parameters have asymptotically optimal performance.
Two Historical Applications of Calculus

(1998). Two Historical Applications of Calculus. The College Mathematics Journal: Vol. 29, No. 2, pp. 93-103.
Constrained Discrimination via MDI Estimation: The Use of Additional Information in Segmentation Analysis

The authors demonstrate a general, flexible constrained discrimination method for testing hypotheses about the segmentability of a target population using categorical descriptors when additional in...
Abstract 1994: Smurf2 mediates ubiquitination and degradation of YY1 to suppress B-cell proliferation and lymphomagenesis.

Proceedings: AACR 104th Annual Meeting 2013; Apr 6-10, 2013; Washington, DC Current treatment of diffuse large B-cell lymphoma (DLBCL), the most common type of non-Hodgkin's lymphoma, has improved patient survival significantly. However, 40-50% of DLBCL patients still die from this disease. There is a critical need to better understand the specific molecular pathways that are perturbed in DLBCL for the development of new and effective therapeutic approaches. We show that mice deficient in the E3 ubiquitin ligase Smurf2 spontaneously develop B-cell lymphomas that resemble human DLBCL with molecular features of germinal center B cells. We discover that Smurf2 mediates ubiquitination and degradation of YY1, a key germinal center transcription factor. Importantly, Smurf2 deficiency enhances YY1-mediated transactivation of c-Myc and B-cell proliferation. Furthermore, the expression of Smurf2 is significantly decreased in primary human DLBCL samples compared to normal B cells, and low levels of Smurf2 expression correlate with poor survival prognosis in DLBCL patients. The Smurf2-YY1-c-Myc regulatory axis represents a novel pathway perturbed in DLBCL that suppresses B-cell proliferation and lymphomagenesis, suggesting Smurf2 as a new therapeutic paradigm for DLBCL. Citation Format: Charusheila Ramkumar, Hang Cui, Yahui Kong, Stephen Jones, Rachel Gerstein, Hong Zhang. Smurf2 mediates ubiquitination and degradation of YY1 to suppress B-cell proliferation and lymphomagenesis. [abstract]. In: Proceedings of the 104th Annual Meeting of the American Association for Cancer Research; 2013 Apr 6-10; Washington, DC. Philadelphia (PA): AACR; Cancer Res 2013;73(8 Suppl):Abstract nr 1994. doi:10.1158/1538-7445.AM2013-1994 Note: This abstract was not presented at the AACR Annual Meeting 2013 because the presenter was unable to attend.
A dual quality control system for large clinical laboratories.

An easily implemented and efficient quality control system for use in large clinical laboratories is described, discussed, and illustrated, with serum cholesterol determinations as an example. A simple method is presented for evaluating day-to-day control in clinical laboratories, in which several trays of sera (for measuring some constituent) may be run on an AutoAnalyzer in a single day. The method utilizes split unknown samples for determining adequate control, or lack of it, in the laboratory. The use of mean charts, as well as range charts, is also discussed, and the use of these two charts in detecting aberrant readings is explored. “Range” is taken to mean the range of difference between split samples.
Theory of the lattice Boltzmann method: Lattice Boltzmann models for non-ideal gases

In this paper a procedure for systematic a priori derivation of the lattice Boltzmann models for non-ideal gases from the Enskog equation (the modified Boltzmann equation for dense gases) is presented. This treatment provides a unified theory of lattice Boltzmann models for non-ideal gases. The lattice Boltzmann equation is systematically obtained by discretizing the Enskog equation in phase space and time. The lattice Boltzmann model derived in this paper is thermodynamically consistent up to the order of discretization error. Existing lattice Boltzmann models for non-ideal gases are analyzed and compared in detail. Evaluation of these models are made in light of the general procedure to construct the lattice Boltzmann model for non-ideal gases presented in this work.
HtrA1 Proteolysis of ApoE In Vitro Is Allele Selective.

Apolipoprotein E (ApoE) belongs to a large class of proteins that solubilize lipids for physiological transport. Humans have three different APOE alleles, APOE e2, APOE e3, and APOE e4, and genetic studies identified ApoE4 as the strongest genetic risk factor for Alzheimer’s disease (AD). People who are homozygous for ApoE4 (i.e., ApoE4/E4) are an order of magnitude more likely to develop late-onset AD (LOAD) than ApoE3/E3 carriers. Several differences between ApoE3 and ApoE4 may contribute to AD including the observation that ApoE4 is degraded to a greater extent than ApoE3 in the human brain. Experiments with high-temperature requirement serine peptidase A1 (HtrA1), which is found in the nervous system, demonstrate that HtrA1 is an allele-selective ApoE-degrading enzyme that degrades ApoE4 more quickly than ApoE3. This activity is specific to HtrA1, as similar assays with HtrA2 showed minimal ApoE4 proteolysis and trypsin had no preference between ApoE4 and ApoE3. HtrA1 has also been reported to cleave ...
An Empirical Investigation of Eastern European Bond Markets

ABSTRACTWe examine the value of Eastern European emerging bond markets to global fixed income managers. In an environment where bonds from traditional developed markets are offering modest yields, emerging market bonds with attractive yields are becoming more popular with institutional managers. Furthermore, the returns on these bonds exhibit low correlations with traditional fixed income investments and thus offer opportunities for portfolio diversification. We develop a multifactor forecasting model and estimate its parameters using a dynamic Kalman filter procedure. The forecasts are then used to construct optimal mean–variance portfolios with and without emerging market bonds. We find that the portfolios that include emerging market bonds have significantly higher Sharpe ratios.
Therapeutic Effectiveness of Adaptive T-Cell Transfer for Minimal Residual Mantle Cell Lymphoma Following High Dose Therapy.

Abstract Mantle cell lymphoma (MCL) is the most aggressive B-cell malignancy with an overall survival of less than four years. Although high-dose therapy followed by stem cell transplantation is effective in reducing the tumor burden and increasing the survival, the patients eventually relapse due to residual lymphoma. Therefore effective therapeutic modalities are needed to target residual MCL. In this study we have developed an immune-based approach to treat minimal residual MCL. HLA matched normal donor mononuclear cells were used to generate dendric cells in vitro. Following characterization, the dendritic cells were fused with the MCL cell line Granta 519 cells to create DC/MCL hybrids. The hybrids were then used to stimulate T cells from the same donor to generate MCL-specific cytotoxic T lymphocytes (CTL). The CTLs were tested for their MCL-specific cytotoxic abilities in vitro against MCL target cells and compared to control T cells or DC primed with MCL lysate or DCs transfected with MCL RNA. HLA matched human breast cancer cell line MDA-231 was used as an irrelevant tumor target. The in vitro results showed the highest MCL specific cytotoxic effects of CTLs generated using DC-MCL hybrids for immunostimulation. As a logical next step, in vivo therapeutic affects the MCL-specific CTLs were tested using a preclinical animal model. Four groups of NOD-SCID mice, with a minimum 10 mice per group, were transplanted with Grant-519 human MCL cell line intravenously. MCL bearing mice were treated with combination chemotherapy (CHOP)over three days followed by transplantation of 1 ×106 mononuclear cells. Ten days after, mice were transplanted with 3 ×106 adoptive T cells weekly for four weeks. The results of the in vivo studies showed that, adoptively transferred T cells that had been stimulated with DC/MCL hybrids were able to significantly inhibit tumor growth in the liver (p = 0.005), kidneys (p = 0.001), and lungs (p= 0.001) of mice with minimal residual MCL compared to control tumor bearing animals as determined by analyzing tumor burden in the organs using virtual images and Neuroinformatica software. When combined with CHOP chemotherapy, adoptively transferred T cells were able to significantly (P = 0.001) extend the survival of the mice by significantly further reducing the tumor burden as compared to mice only receiving the chemotherapy plus unmanipulated T cells. Specificity of the CTL mediated response was also confirmed by cytokine profiling in vitro and in vivo. In summary, we have clearly shown that antigen-primed DCs can be used to activate MCL-specific T cells which, when administered adoptively, are effective in treating minimal residual MCL. Thus these studies lay foundation for a PhaseI/II clinical trial. (This study was supported by the Lymphoma Research Foundation, New York, NY).
High-Energy Amplitudes in {N} = 4 {SYM} in the Next-to-Leading Order

The high-energy behavior of the of SYM amplitudes in the Regge limit can be calculated order by order in perturbation theory using the high-energy operator expansion in Wilson lines. At large Nc, a typical four-point amplitude is determined by a single BFKL pomeron. The conformal structure of the four-point amplitude is fixed in terms of two functions: pomeron intercept and the coefficient function in front of the pomeron (the product of two residues). The pomeron intercept is universal while the coefficient function depends on the correlator in question. The intercept is known in first two orders in coupling constant : LO BFKL intercept and NLO BFKL calculated in Ref. [1]. As an example of using the Wilson-line OPE, we calculate the coefficient function in front of the pomeron for the correlator of four Z2 currents in the leading and next-to-leading order.
Understanding the Behavior of Distressed Stocks

We construct an asset pricing model with explicit default to develop a risk-based source of the distress anomaly. We show that distress produces sharply countercyclical betas leading to biased estimates of risk premia and alphas. This effect is amplified when earnings growth is mean-reverting, so that distressed stocks also have high expected future earnings. This bias can account for between 39 and 76 percent of the distress anomaly in a calibrated economy that replicates the key characteristics of these stocks.
Abstract 2489: Mre11-CDK2 interaction during the DNA double-strand break response

The MRN (Mre11/Rad50/NBS1) complex is a group of highly conserved proteins central to the detection and repair of DNA double-strand breaks (DSBs). Inherited deficiencies in DNA DSB signaling result in a spectrum of disorders featuring cancer predisposition, neurodegeneration, and immunodeficiency. MRN directly binds DNA DSB ends and facilitates activation of ataxia-telangiectasia mutated (ATM) kinase, which initiates cellular responses including DNA repair, cell cycle checkpoints, and in some circumstances, apoptosis. Cellular responses to DNA DSBs require rapid communication between DNA repair complexes and the cell cycle machinery, but much about this relationship remains unclear. Our lab recently discovered an interaction between Mre11 and Cyclin-dependent kinase 2 (CDK2), a key component of the cell cycle machinery (Buis et al., NSMB, 2012). CDK2, when bound to its regulatory partner Cyclin A, promotes cell cycle progression through S phase. We demonstrated that the Mre11-CDK2/Cyclin A interaction is important in regulating the capacity for DNA repair by homologous recombination in normally dividing cells. Current work is focused on understanding the role of this interaction during DNA damage responses. We hypothesize that Mre11 interaction with CDK2 is a component of a molecular switch between the normal cell cycle and the DNA damage response. To test our hypothesis, we take advantage of murine alleles of Mre11 previously generated in the lab. We performed immunoprecipitation studies to investigate the protein-protein interaction in the presence of DNA damage. We also utilized kinase inhibitors to investigate the role of apical kinases in regulating the interaction. Finally, we are currently optimizing in vitro kinase assays to further understand a relationship between Mre11 and CDK2 enzymatic activity.Unpublished findings reveal that the Mre11-CDK2/Cyclin A interaction is altered upon DNA damage, a process which appears to be important for cell cycle checkpoint regulation. In conclusion, we demonstrate that the Mre11-CDK2 interaction plays important roles both in normally dividing cells and in the DNA damage response. Taken together, our data suggests that Mre11 may act to bridge the gap between DNA repair complexes and the cell cycle machinery. Citation Format: Mary J. Morgan, Todd A. Festerling, Jeffrey Buis, David O. Ferguson. Mre11-CDK2 interaction during the DNA double-strand break response [abstract]. In: Proceedings of the American Association for Cancer Research Annual Meeting 2017; 2017 Apr 1-5; Washington, DC. Philadelphia (PA): AACR; Cancer Res 2017;77(13 Suppl):Abstract nr 2489. doi:10.1158/1538-7445.AM2017-2489
Impact of sodium-rich contaminant on wafer level chip scale package (WLCSP) devices during reliability package stress test

Wafer level chip scale package (WLCSP) devices have seen significant growth and demand in the recent years largely driven by the mobile consumer market. WLCSP offers significantly reduced package footprint, high electrical and thermal performance, and lower cost of manufacturing. After the initial qualification of the device, an ongoing reliability monitor program is critical in ensuring the continued high reliability of devices shipped out to the customers. The paper focuses on the effect and impact of handling-induced contamination containing sodium (Na) on the package integrity of the WLCSP during reliability stress test and describes the physical mechanism explaining the delamination and the eventual cracking of the metal bond pad and metal redistribution layer (RDL). Proper WLCSP handling procedures during reliability testing are also outlined to eliminate extrinsic issues that may obscure intrinsic reliability failures.
Strong-coupling Bose polarons out of equilibrium: Dynamical renormalization-group approach

When a mobile impurity interacts with a surrounding bath of bosons, it forms a polaron. Numerous methods have been developed to calculate how the energy and the effective mass of the polaron are renormalized by the medium for equilibrium situations. Here, we address the much less studied nonequilibrium regime and investigate how polarons form dynamically in time. To this end, we develop a time-dependent renormalization-group approach which allows calculations of all dynamical properties of the system and takes into account the effects of quantum fluctuations in the polaron cloud. We apply this method to calculate trajectories of polarons following a sudden quench of the impurity-boson interaction strength, revealing how the polaronic cloud around the impurity forms in time. Such trajectories provide additional information about the polaron's properties which are challenging to extract directly from the spectral function measured experimentally using ultracold atoms. At strong couplings, our calculations predict the appearance of trajectories where the impurity wavers back at intermediate times as a result of quantum fluctuations. Our method is applicable to a broader class of nonequilibrium problems. As a check, we also apply it to calculate the spectral function and find good agreement with experimental results. At very strong couplings, we predict that quantum fluctuations lead to the appearance of a dark continuum with strongly suppressed spectral weight at low energies. While our calculations start from an effective Fr\"ohlich Hamiltonian describing impurities in a three-dimensional Bose-Einstein condensate, we also calculate the effects of additional terms in the Hamiltonian beyond the Fr\"ohlich paradigm. We demonstrate that the main effect of these additional terms on the attractive side of a Feshbach resonance is to renormalize the coupling strength of the effective Fr\"ohlich model.
Investigating ioflupane I123 injection and single photon emission tomography as an imaging biomarker for long-term sequelae following mild traumatic brain injury.

Objective: To determine whether there were differences in clinical outcomes for ioflupane I123 injection (DaTscan) and single photon emission tomography consistent with early Parkinson’s disease (P...
Asians have more perianal Crohn disease and ocular manifestations compared with white Americans.

Background: Inflammatory bowel disease (IBD) is increasing in Asians. We sought to better understand differences in IBD between Asians and whites in the United St
Adding sodium information to casual dining restaurant menus: beneficial or detrimental for consumers?

Abstract High sodium levels in restaurant food have prompted Philadelphia and New York City to require inclusion of sodium content in addition to calories on menus to “nudge” consumers toward lower sodium foods. However, taste perceptions may impact the effectiveness of this intervention. An online survey tested whether sodium and calorie menu nutrition information (MNI) influenced consumer choices from a casual dining restaurant menu, accounting for consumers’ intuition about taste of food relative to sodium, calories, and healthiness. Consumer choices were assessed based on calorie and sodium content of the menu items they selected. Participants were randomized to a menu with (1) calorie MNI only, (2) calorie plus numeric sodium MNI, (3) calorie MNI plus a sodium warning symbol for foods with 2300 mg of sodium or more, or (4) no MNI. Calorie plus numeric sodium MNI was associated with selection of meals lower in sodium compared to meals from the calorie MNI only menu or no MNI menu, but only for consumers with a taste intuition that (relatively) lower sodium, lower calorie, healthy foods were tasty. Consumers with the opposite taste intuition *(foods with these characteristics are not tasty) ordered meals higher in sodium. Inclusion of the sodium warning symbol did not result in a significantly different meal sodium content compared to the other menu conditions, regardless of taste intuition. However, differing levels of taste intuition alone, without consideration of MNI, was associated with ordering meals of significantly different calorie content. Overall, findings suggest adding calorie plus numeric sodium MNI may lead to beneficial outcomes (i.e., selecting meals lower in sodium) for some consumers and detrimental outcomes (i.e., selecting meals higher in sodium) for others, depending on their taste intuition.
Characterization, Categorization, and 5-Year Mortality of Medicine High Utilizer Inpatients.

Background:Patients who are frequently admitted to Medicine inpatient services comprise a distinct subset of readmitted patients about whom not much is known.Objective:We sought to characterize thi...
Meet your public relations team: People with dark traits may help you manage your image

Abstract Although previous research suggests that people with high levels of Dark Triad (DT) traits (grandiose narcissism, Machiavellianism, psychopathy) are typically responsible for a disproportionate amount of harm, we propose that such individuals are more likely to help others self-present desired images (i.e., engage in beneficial-impression-management; BIM). In Study 1, participants completed indices of the DT and vulnerable narcissism, and they self-reported their likelihood of using various BIM tactics. DT traits and vulnerable narcissism related to enhanced anticipated use of BIM tactics for both friends and enemies. In Study 2, participants had the opportunity to exaggerate a friend's qualifications on a mock job application under conditions of either high or low self-gain. Each dark trait related to exaggerated ratings of the friend's qualifications, and these effects were particularly pronounced under high self-gain. Findings provided insight on how DT traits and vulnerable narcissism relate to a form of social benevolence but also highlight that such benevolence seems, in part, selfish.
Fabrication and Characterization of Buried Glass Waveguides with Symmetric Index Profile

Diffusion studies and modal behavior of Ag+-Na+ exchanged planar waveguides in glass substrate are presented. In addition, a simple SEM technique to determine the refractive index profile and the realization of symmetrical duried waveguides with fiber-like refractive index profile are also reported.
t-neuron, a one dimensional spiking model that reproduces in vitro and in vivo spiking characteristics of cortical neurons

Models in neurobiology have played a major role in our understanding of neural information processing. Modeling strategies typically take two divergent routes: detailed compartmental models of single neurons and theoretical models of large scale networks. Compartmental models strive to examine in detail the consequence of biophysical characteristics of the neural membrane on the activity of the cell and elucidate the biological mechanism underlying the cells behavior (for example see [Jaeger et al., 1997; Segev et al., 1989] ). Due to the computational requirements simulations of extended networks of such in computo neurons are not feasible. Large scale models on the other hand concern themselves with information processing in large assemblies of neural units which are often ad hoc abstractions of neurons or local neural circuits (e.g. binary neurons [Van Vreeswejk Sompolinsky, 1996] or rate-coding units [Ermentrout Cowan, 1980] ). In fact the single most popular computational unit in spiking neural networks is the integrate-and-fire neuron (IFN) which is computationally cheap, but carries with it a number of pathological characteristics. Furthermore the IFN is a phenomenological model and has become popular in the literature largely out of convenience. We suggest that much of future progress in theoretical neuroscience shall depend on connecting the two modeling approaches by developing methods for formal reduction of detailed models to simpler, more tractable ones. Here we exhibit a technique for reduction and the resulting one-dimensional neural model.
Perceptions of telemedicine for patient education among online support group patients with chronic or rare conditions

Effective patient education among individuals with rare or chronic conditions is important for health outcomes, but difficult because of patients’ evolving needs. Telemedicine for patient education...
Cross-dressing and sex change stories in Spanish illustrated magazines (1928–1936)

During the 1920s and 1930s, the impression that the boundaries between the sexes were increasingly blurring was pervasive in many parts of the world. In Spain, sexual ambiguity often became the focus of public discussions on the upheaval of the traditional gender order. As part of this phenomenon, stories of cross-dressers made good copy in popular illustrated magazines such as Nuevo Mundo, Mundo Grafico, Estampa, and Cronica, which were the top-sellers of their kind during the interwar period. By analyzing a group of cross-dressing and sex change stories from these periodicals – the way they were told and interpreted – I shed light on the ways in which the perceived fluidity of gender was constructed in a medium that reached a relative large segment of the Spanish population. The journalistic pieces I consider manifested different reactions to sexual ambiguity that ranged from the condemnatory to the matter-of-fact. Regardless, they all contributed – implicitly or explicitly – to undermine essentialist arguments underpinning the ideology of separate spheres of action for men and women. On occasion, these texts put forth an intimation, avant la lettre, of Judith Butler’s notion of the performativity of gender.
Emotions are the experiential glue of learning environments in the 21st century

Abstract This article comments on the five papers published in this special issue on understanding and measuring emotions in technology-rich learning environments. The articles identify a number of emotions that frequently occur in digital learning environments across different tasks, goals, populations, and subject matters. The Control Value Theory of achievement emotions unifies the research reported in the articles, whereas social emotions surface in contexts where there are significant social interactions, such as group learning or the training of medical students. The emotions that were detected and tracked in the reported studies rely on self-reports of learners and judges who observe them. This commentary identifies a number of limitations of the studies that will hopefully stimulate future research. Researchers are encouraged to collect (1) larger sample sizes, (2) longer interventions with learning technologies, (3) physiological, multimodal, and behavioral signatures of emotions to complement the subjective judgments, (4) more precise timing and transitions between emotions to uncover emotion dynamics, (5) assessments of nonlinear relations between variables, and (6) interventions designed to regulate and productively respond to learner emotions.
Abstract WP287: Deterioration in Recombinant Tissue Plasminogen Activator After Repeated Freezing and Thawing Cycles for Thromboelastography

Background and Purpose: Thromboelastography (TEG) is often used to measure coagulation dynamics in the setting of acute ischemic stroke and thrombolytic therapy. The stability of thrombolytics has ...
A Virtuous Hearer: An Exploration of Epistemic Injustice and an Ethic of Care in Public Encounters

The traditional street-level bureaucracy literature views public encounters, the interaction between frontline service providers and the people they serve, as inherently problematic and oppressive ...