cssi/SciSciGPT-SciSciNet huggingface dataset:
22.3 Adaptive reconfigurable voltage/current-mode power management with self-regulation for extended-range inductive power transmission

Wireless power transmission (WPT) via inductive coupling is used in many applications such as biomedical implants, sensors, and radio-frequency identification (RFID). Range extension, robustness against load (R L ) variations and coil misalignments and rotations, and miniaturization of inductive links are key in such applications, demanding new architectures for the integrated power management (IPM) [1–6]. Conventional IPMs in the form of rectifiers or doublers operate in voltage mode (VM) using active synchronous switches to achieve high AC-DC power-conversion efficiency (PCE) in [1–3]. However, they suffer from limited voltage-conversion efficiency (VCE), requiring large AC carriers across the receiver (RX) LC-tank. In [4], the RX LC-tank has been shorted twice in every power carrier cycle for R L modulation. Although this approach increases PTE for small R L , it is not suitable for large R L and VCE is still less than 1. A resonant current-mode (CM) IPM has recently been presented in [5], primarily used for recharging battery-powered implants with sub-volt AC carriers. However, it requires a battery for startup and is not suitable for direct WPT. For applications that involve large coupling distance (d) and R L variations, neither VM- nor CM-only IPMs achieve highest power transmission efficiency (PTE), because VM and CM are suitable for small and large d or R L , respectively [6].
Family-to-Work Conflict: Gender, Equity and Workplace Policies

Balancing parenthood and a successful career in workplace holds unique challenges, especially for women who often report greater demands in terms of child care and family obligations. Gender and pa...
The Staurocentric Logic of Eberhard Jüngel: Pneumatology and Ecclesiology

Ecclesiology and pneumatology remain two areas of Eberhard Jungel's thought that are repeatedly critiqued as being ‘underdeveloped’ or ‘deficient’ due to his reliance on an Augustinian grammar in describing the Holy Spirit. This article argues for a revised understanding of both Jungel's trinitarian theology and ecclesiology in light of his commitment to staurocentrism. Jungel's staurocentric doctrine of God, for which he is so often lauded, is only possible because of the Augustinian grammar he accepts for his pneumatology. Only as the bond of love, the relation between the relations, can the Spirit make clear how it is that the triune God, fully identified with the life of Jesus, can die. Ultimately, Jungel builds on Augustine's doctrine of the Spirit to demonstrate two distinct, yet interrelated, theological principles: first, that the person of the Spirit is indispensible within the event of God's triune being; and second, that within the church it is the Spirit's personhood, uniquely, which makes possible ecclesial correspondence to God.
Die Struktur des Einfachen Bogens

Wir wollen in diesem Kapitel uber die Struktur des einfachen Bogens (siehe Erklarung auf Seite 28) Klarheit gewinnen. Wir bezeichnen das Anfangselement mit A*a, das Endelement mit B*b. Ferner bedeute U den Schnittpunkt ab und u die Verbindungsgerade AB (Figur 42).
Making the Invisible Visible: The Presence of Older Women Artists in Early Modern Artistic Biography

In her seminal book The Obstacle Race: the Fortunes of Women Painters and Their Work (2001), Germaine Greer writes of the ridicule faced by eighteenth-century painters Anna Dorothea Lisiewska-Therbusch and Giulia Lama as they reached middle age‚ due to their purported lack of physical attractiveness. This chapter follows up on Greer’s work and further examines verbal and visual characterisations of older women artists of the early modern period (i.e. 1400−1800) to consider whether this discourse of humiliation was the norm, as well as to see how such characterisations compare to those of elder male artists.
Decision support tool for Strategic National Stockpile (SNS) supply chain policies

In this paper, we describe the development of a decision support tool to assist the Division of Strategic National Stockpile (DSNS) at the Centers for Disease Control and Prevention (CDC) with effectively responding to future public health emergencies. The DSNS is responsible for managing the Strategic National Stockpile (SNS), which is the nation's largest inventory of medical supplies to utilize during a disaster. In the case of a large scale public health emergency, syringes and needles are needed in mass quantities, hence creating excess demand and thus requiring needles and syringes to be removed from the commercial supply chain. Consequently, there is a need to minimize the time to recovery and degree of degradation for the commercial supply chain. The approach focuses on developing a decision support tool through the use of an Economic Order Quantity (EOQ) model and a disaster demand forecast algorithm. The inputs of the tool include factors related to the disaster scenario as well as various policy options. The decision support tool will allow the DSNS to understand how designated factors and policies affect the effectiveness of the response. The policy options will be evaluated in terms of their impact on the recovery time for the commercial supply chain to resume routine patterns, as well as degree of degradation, or the amount of delay and backup over the course of the disaster timeframe.
The Laplacian and Related Operators

Starting from first principles, all fundamental solutions (that are tempered distributions) for scalar elliptic operators are identified in this chapter. While the natural starting point is the Laplacian, this study encompasses a variety of related operators, such as the bi-Laplacian, the poly-harmonic operator, the Helmholtz operator and its iterations, the Cauchy–Riemann operator, the Dirac operator, the perturbed Dirac operator and its iterations, as well as general second-order constant coefficient strongly elliptic operators. Having accomplished this task then makes it possible to prove the well-posedness of the Poisson problem (equipped with a boundary condition at infinity), and derive qualitative/quantitative properties for the solution. Along the way, Cauchy-like integral operators are also introduced and their connections with Hardy spaces are brought to light in the setting of both complex and Clifford analyses.
Evaluation of Prostate Specific Acid Phosphatase and Prostate Specific Antigen in Identification of Prostatic Cancer

AbstractThe peroxidase-anti-peroxidase technique was used to stain for prostate specific acid phosphatase and prostate specific antigen in 12 patients with primary tumors and in 12 patients with metastases in whom the nature of the tumor was in doubt after routine histopathological studies. Nine of the primary tumors were positive for both markers and an additional 2 tumors stained for prostate specific antigen only. Six metastatic lesions stained for both markers and a seventh for prostate specific antigen alone. Thus, 11 of 12 primary tumors and 7 of 12 metastases studied were proved to be of prostatic orgin. While the peroxidase staining was sometimes weak and uneven this method, using prostate specific antigen and prostate specific acid phosphatase, allowed for ready identification of metastases. The heterogeneity of the tumors in regard to these 2 prostate markers is demonstrated, and the value of staining for prostate specific acid phosphatase and prostate specific antigen is emphasized.
Spectrum of Delayed Neutrons from the Thermal-Neutron Fission of Uranium-235

Measurements of the spectra of delayed neutrons from the thermal fission of 235U are reported over the energy range 30 to 1500 keV. The resolution is sufficient to identify locations of peaks in th...
Development of Heterogeneous Catalysts for Dehydration of Methanol to Dimethyl Ether: A Review

Dimethyl ether (DME) is a promising multisource and multipurpose clean fuel and value-added chemical synthesized from syngas. This process can be either performed in a single stage (direct process) using a dual catalysis system or a two stage (indirect process) where syngas is first converted into methanol and then dehydrated to produce DME. While the dehydration reaction has been studied extensively over multiple decades, to date no review has been conducted on the catalysts involved in the methanol dehydration reaction. This work demonstrates the state of the art in catalyst preparation and analysis for this application. The dominant catalysts are studied extensively in this work, including γ-Al2O3 and various zeolites, such as ZSM-5, Y, beta and mordenite as well as their relevant modifications. Additionally, silica-alumina, mesoporous silicates, alumina phosphate, silicoaluminophosphates, heteropoly acids (HPAs), metal oxides, ion exchange resins and quasicrystals are discussed in this work, owing to the wide variety of catalysts available and studied for the purposes of methanol dehydration to DME.
Atrial cardiopathy: A new cause for stroke?

Recent studies suggest that abnormalities of the left atrium in the absence of atrial fibrillation (AF) may increase risk of stroke, either as precursors to AF or as independent risk factors for the development of atrial thrombus and subsequent stroke. Markers for atrial disease, such as left atrial enlargement (LAE) on echocardiogram, evidence of left atrial abnormality demonstrated by increased p-wave terminal force in lead V1 (PTFV1) on ECG, and increased serum levels of a form of brain natriuretic peptide (NT-proBNP), have been associated with increased stroke risk and used to define a new entity known as atrial cardiopathy.1
Data analysis in participatory action research: using poetic inquiry to describe urban teacher marginalization:

This paper recommends the arts-based method of poetic inquiry for data analysis within PAR projects. Poems can express emotion, protect participant identities, and provide a generative medium throu...
Neurological commentary addressing the article titled "Guidance for switching from off-label antipsychotics to pimavanserin for Parkinson's disease psychosis: an expert consensus".

Parkinson’s disease psychosis (PDP) occurs commonly and can comprise the most troubling symptoms among the many that occur with this illness. Prior treatment options for PDP have been limited and unsatisfactory due to uneven efficacy data, burdensome monitoring, and lack of a specific FDA indication coupled with warnings of increased mortality. Pimavanserin, approved for the treatment of PDP by the FDA in 2016, overcomes some of these obstacles, with data proven efficacy and without the frequent monitoring required for clozapine. This presents an opportunity to transition patients with PDP to pimavanserin from older therapies. Black and colleagues provide their thoughtful recommendations on how to achieve this transition to pimavanserin while maintaining symptom control and minimizing disruptions that might occur with a medication change.
Modeling of Robotic Fish Propelled by a Servo/IPMC Hybrid Tail

This paper presents modeling of robotic fish propelled by a hybrid tail with Servo and IPMC actuated two joints. The first joint is driven by a servo motor, which generates flapping motion for main propulsion. The second joint is actuated by a soft actuator, or ionic polymer-metal composite (IPMC) artificial muscle, which directs the propelled fluid for steering. A dynamic model is developed to capture the 2D motion dynamics of the robotic fish. The model fully captures the actuation dynamics of the IPMC soft actuator, two-link tail motion dynamics, and body motion dynamics. Experimental results have shown that the robotic fish is capable of swimming forward (up to 0.45 body length/second) and turning left and right (up to 40 degree/sec) with a small turning radius (less than half a body length). Finally, the dynamic model has been validated with experimental data, in terms of steady-state forward speed and turning speed versus the flapping frequency.
The BASILICA Trial: Prospective Multicenter Investigation of Intentional Leaflet Laceration to Prevent TAVR Coronary Obstruction.

Abstract Objectives The BASILICA (Bioprosthetic or native Aortic Scallop Intentional Laceration to prevent Iatrogenic Coronary Artery obstruction during TAVR) investigational device exemption trial was a prospective, multicenter, single-arm safety and feasibility study. Background Coronary artery obstruction is a rare but devastating complication of transcatheter aortic valve replacement (TAVR). Current stent-based preventative strategies are suboptimal. Bioprosthetic or native aortic scallop intentional laceration to prevent iatrogenic coronary artery obstruction during TAVR (BASILICA) is a novel transcatheter technique performed immediately before TAVR to prevent coronary artery obstruction. Methods Subjects with severe native or bioprosthetic aortic valve disease at high or extreme risk for surgery, and at high risk of coronary artery obstruction, were included. The primary success endpoint was successful BASILICA and TAVR without coronary obstruction or reintervention. The primary safety endpoint was freedom from major adverse cardiovascular events. Data were independently monitored. Endpoints were independently adjudicated. A core laboratory analyzed computed tomography images. Results Between February 2018 and July 2018, 30 subjects were enrolled. Primary success was met in 28 (93%) subjects. BASILICA traversal and laceration was successful in 35 of 37 (95%) attempted leaflets. There was 100% freedom from coronary obstruction and reintervention. Primary safety was met in 21 (70%), driven by 6 (20%) major vascular complications related to TAVR but not BASILICA. There was 1 death at 30 days. There was 1 (3%) disabling stroke and 2 (7%) nondisabling strokes. Transient hemodynamic compromise was rare (7%) and resolved promptly with TAVR. Conclusions BASILICA was feasible in both native and bioprosthetic valves. Hemodynamic compromise was uncommon. Safety was acceptable and needs confirmation in larger studies. BASILICA appears effective in preventing coronary artery obstruction from TAVR in subjects at high risk.
Ellen Steinberg Jim Russell

Ellen Steinberg is group creative director and executive vice president at McKinney in Durham, NC (mckinney.com). She joined McKinney in 2006 after serving as co-creative head of Fallon New York. Steinberg’s work has won virtually every major creative award and covers such iconic brands as Sherwin-Williams, Russell Beam, Miller Lite, Nikon, and Sports Illustrated. She has served as a juror for Communication Arts competitions and the One Show. Steinberg is a graduate of the University of Delaware. She is also a yoga instructor and a justice of the peace.
“I Belong Here.”: Culturally Sustaining Pedagogical Praxes from an Alternative High School in Brooklyn

Despite persistent class and race inequalities in educational attainment and achievement in the U.S., hegemonic cultural ideologies and urban education politics and policies continue to proceed from an insistence that education is the great equalizer. These ideologies do not take into account the ways that normative school culture and pedagogical praxes take for granted middle-class, white-supremacist cultural assumptions that privilege student populations whose social locations already probabilize high rates of achievement and attainment. Vast research published in The Urban Review and elsewhere has demonstrated the importance and efficacy of culturally sustaining pedagogy for improving outcomes for economically marginalized students of color (Allen in Urban Rev 47(1):209–231, 2015; Delpit in Harv Educ Rev 56(4):379–386, 1995; Farinde-Wu et al. in Urban Rev 49(2):279–299, 2017; Gay in culturally responsive teaching: theory, research, and practice, Teachers College Press, New York, 2010; Graves in Berkeley Rev Educ 5(1):5–32, 2014; Jemal in Urban Rev 49(4):602–626, 2017; Ladson-Billings in Crossing over to Canaan: the journey of new teachers in classrooms, Jossey-Bass, San Francisco, 2001, The dreamkeepers: successful teachers of African American children, Jossey-Bass Publishers, San Francisco, 2009; Lee in Culture, literacy and learning: taking bloom in the midst of the whirlwind, Teachers College Press, New York, 2006; Marciano in Urban Rev 49(1):169–187, 2016; Nieto in Language, culture, and teaching: critical perspectives, Routledge, New York, 2010; Paris in Educ Res 41(3):93–97, 2012; Paris and Alim in Culturally sustaining pedagogies: teaching and learning for justice in a changing world, Teachers College Press, New York, 2017; Wiggan and Watson in Urban Rev 48(5):766–798, 2016; Yosso in Race Ethn Edu, 8(1):69–91, 2005). This article uses rich ethnographic data from a transfer school in Brooklyn, New York that serves financially insecure youth of color who are “over-age and under-credited.” These data and my analysis showcase the expertise and indigenous knowledges of teachers who practice cultural relevance and critical racial awareness in order to engage, retain, graduate and prepare students who are historically and presently marked for failure by an education system that has always been more adept at reproducing social inequality than disrupting it (Borck in Qual Inq 20(10):1–8, 2016).
Learning User Preferences from Social Multimedia Analysis and Overview of the iFood2019Challenge

There has been an explosion of multimodal content generated on social media networks in the last few years, which has necessitated a deeper understanding of social media content and user behavior. In the first part of the task, I will present a novel method that provides a unified framework for understanding content as well as modeling user preferences from noisy social media posts. I will discuss some applications in understanding food preferences and trends using this algorithm. I will then give an overview of the second large-scale food classification challenge in images (iFood challenge) held as part of the sixth Fine Grained Visual Classification Workshop at CVPR19. We introduce a new dataset of 251 fine-grained (prepared) food categories with 118K training images collected from the web, and human verified labels for both validation set (11K images) and the test set (12K images). 40 teams from academia and industry competed in this challenge with the top team obtaining a 5.6% top-3 error percentage, which is almost 2-points better than previous year challenge.
Harmful Stakeholder Strategies

Stakeholder theory focuses on how more value is created if stakeholder relationships are governed by ethical principles such as integrity, respect, fairness, generosity and inclusiveness. However, it has not adequately addressed strategies that stakeholders perceive as harmful to their interests and how this perception can even lead some stakeholders to view the firm’s strategies as unethical. To fill the void, this paper directly addresses strategies that stakeholders perceive as harmful to their interests, or what we refer to as harmful stakeholder strategies. Specifically, it identifies factors associated with stakeholder perceptions of harm that are likely to cause them to consider a strategy unethical, examines the negative implications for firms that pursue such strategies in terms of likely stakeholder responses and damage to stakeholder relationships, and provides theory to help explain how firms are likely to respond to stakeholder claims that a strategy is unethical, based on factors such as the strategic importance of the claim to the firm, how long the strategy has been in use, the costs of remediation, the risk of stakeholder mobilization or new regulation, and whether firms can reasonably rationalize their actions. Assessing harm allows a firm to make a more accurate estimate of the costs of a strategy and can assist managers in allocating resources intended to reduce or remediate harm.
Iterative user and expert feedback in the design of an educational virtual reality biology game

ABSTRACTThis study focuses on an educational game titled Cellverse, a two-player cross-platform VR project intended to teach high school biology students about cell structure and function. In Cellv...
Clinical Analysis of 122 Cases with Mycoplasma Pneumonia Complicated with Atelectasis: A Retrospective Study.

This study aims to explore the clinical characteristics, treatment, and prognosis of mycoplasma pneumonia complicated with atelectasis. A retrospective analysis was performed on 122 children with mycoplasma pneumonia complicated with atelectasis. These children were hospitalized in the Xiamen Campus of the Pediatric Hospital of Fudan University and the Children’s Hospital of Xiamen between December 2015 and December 2018. A diagnosis was made for each case on the basis of the clinical symptoms and signs, Mycoplasma pneumoniae-specific IgM antibody, and imaging results. Among the 122 cases with mycoplasma pneumonia complicated with atelectasis, all cases had retractable M. pneumoniae infection, 102 cases underwent fibrobronchoscopic lavage treatment, and all cases were treated with macrolide antibiotics after a definite diagnosis was made. Furthermore, 107 cases improved and were discharged. Follow-up was performed for 3–4 weeks for all patients, and all patients, including the five cases with retractable disease, recovered well. The major clinical manifestations for M. pneumoniae pneumonia are fever and stimulatory dry cough. Macrolide antibiotics remain the treatment of choice.
An Effective and Efficient Automatic Test Pattern Generation (ATPG) Paradigm for Certifying Performance of RSFQ Circuits

Rapid single flux quantum (RSFQ) logic, based on Josephson junctions (JJs), is seeing a resurgence as a way for providing high performance in the era beyond the end of physical scaling of complementary metal-oxide-semiconductor (CMOS). Due to its use of fabrication processes with large feature sizes, the defect density for RSFQ is lower than its CMOS counterpart. Hence, process variations and other RSFQ-specific nonidealities are major causes of chip failures. Because of the nature of its quantized pulse-based operation, even highly distorted pulses are interpreted logically correctly by cells, but the timings are affected. Therefore, timing verification and delay testing increase in importance in RSFQ. Our goal is to ensure that designs and fabricated chips provide desired performance. To achieve this goal, we propose new methods and tools for timing verification and delay testing of fully path balanced RSFQ logic circuits that use concurrent-flow clocking scheme. We address several radically new phenomena in the RSFQ technology, especially the existence of single-pattern delay tests and the need to propagate delayed values via multiple pipeline stages. We then characterize cells under process variations and identify delay excitation conditions, sensitization conditions, and conditions for propagation of the logic errors caused by timing violations due to process variations. We then propose a completely new paradigm for automatic test pattern generation (ATPG) which utilizes these new phenomena to select multicycle paths as targets and to generate test patterns that are guaranteed to excite the worst-case delay along each target multicycle path. Finally, we present theoretical proofs and Monte Carlo simulation results for benchmark circuits under process variations to demonstrate that the patterns generated by our new ATPG are effective (invoke maximum delays of target multicycle paths) and efficient (require small numbers of patterns).
Applying Q methodology to teacher evaluation research

Abstract This article examines Q methodology as an empirical approach for use in teacher evaluation research, specifically research examining evaluative measures as applied to teachers of students with disabilities. Q is a qualiquantalogical method that requires participants to order or scale items relative to each other in characterizing a person or behavior. Participant viewpoints are intercorrelated and factor analyzed to determine common viewpoints regarding the salience of items representing a particular domain. This article provides an overview of Q methodology and includes a description of a study that used Q to determine common viewpoints of the salient features of special education teachers’ instructional practices. Implications for using Q in teacher evaluation research broadly and special education teacher evaluation specifically are discussed.
A Data-Driven Based Strategy to Evaluate Participation of Diverse Social Classes in Smart Electric Grids

The grand transition of electric grids from conventional fossil fuel resources to intermittent bulk renewable resources and distributed energy resources (DERs) has initiated a paradigm shift in power system operation. Distributed energy resources (i.e. rooftop solar photovoltaic, battery storage, electric vehicles, and demand response), communication infrastructures, and smart measurement devices provide the opportunity for electric utility customers to play an active role in power system operation and even benefit financially from this opportunity. However, new operational challenges have been introduced due to the intrinsic characteristics of DERs such as intermittency of renewable resources, distributed nature of these resources, variety of DERs technologies and human-in-the-loop effect. This paper mainly focuses on demand response (DR), which is a major type of DERs and is highly influenced by human-in-the-loop effect. A data-driven based analysis is implemented to analyze and reveal the human-in-the-loop effect. The results confirm the critical impact of demographic characteristics of customers on their interaction with smart grid and their quality of service (QoS). The proposed framework is also applicable to other types of DERs.
Code, Connect, Create: The 3C Professional Development Model to Support Computational Thinking Infusion

Despite the increasing attention to infusing CT into middle and high school content area classrooms, there is a lack of information about the most effective practices and models to support teachers in their efforts to integrate disciplinary content and CT principles. To address this need, this paper proposes the Code, Connect and Create (3C) professional development (PD) model, which was designed to support middle and high school content area teachers in infusing computational thinking into their classrooms. To evaluate the model, we analyzed quantitative and qualitative data collected from Infusing Computing PD workshops designed for in-service science, math, English language arts, and social studies teachers located in two Southeastern states. Drawing on findings from our analysis of teacher-created learning segments, surveys, and interviews, we argue that the 3C professional development model supported shifts in teacher understandings of the role of computational thinking in content area classrooms, as well as their self-efficacy and beliefs regarding CT integration into disciplinary content. We conclude by offering implications for the use of this model to increase teacher and student access to computational thinking practices in middle and high school classrooms.
The Effect of NFL and NCAA Football Games on the Spread of COVID-19 in the United States: An Empirical Analysis

ABSTRACT Importance In 2020 and early 2021, the National Football League (NFL) and National Collegiate Athletic Association (NCAA) had opted to host games in stadiums across the country. The in-person attendance of games has varied with time and from county to county. There is currently no evidence on whether limited in-person attendance of games has caused a substantial increase in coronavirus disease 2019 (COVID-19) cases. Objective To assess whether NFL and NCAA football games with limited in-person attendance have contributed to a substantial increase in COVID-19 cases in the counties they were held. Design In this time-series cross-sectional study, we matched every county hosting game(s) with in-person attendance (treated) in 2020 and 2021 with a county that has an identical game history for up to 14 days (control). We employed a standard matching method to further refine this matched set so that the treated and matched control counties have similar population size, non-pharmaceutical intervention(s) in place, and COVID-19 trends. We assessed the effect of hosting games with in-person attendance using a difference-in-difference estimator. Setting U.S. counties. Participants U.S. counties hosting NFL and/or NCAA games. Exposure Hosting NFL and/or NCAA games. Main outcomes and measures Estimating the impact of NFL and NCAA games with in-person attendance on new, reported COVID-19 cases per 100,000 residents at the county-level up to 14 days post-game. Results The matching algorithm returned 361 matching sets of counties. The effect of in-person attendance at NFL and NCAA games on community COVID-19 spread is not significant as it did not surpass 5 new daily cases of COVID-19 per 100,000 residents on average. Conclusions and relevance This time-series, cross-sectional matching study with a difference-in-differences design did not find an increase in COVID-19 cases per 100,000 residents in the counties where NFL and NCAA games were held with in-person attendance. Our study suggests that NFL and NCAA football games hosted with limited in-person attendance do not cause a significant increase in local COVID-19 cases. Key points Question Did NFL and NCAA football games with limited in-person attendance cause a substantia increase in coronavirus disease 2019 (COVID-19) cases in the U.S. counties where the games were held? Findings This time-series, cross-sectional study of U.S. counties with NFL and NCAA football games used matching and difference-in-differences design to estimate the effect of games with limited in-person attendance on county-level COVID-19 spread. Our study does not find an increase in county-level COVID-19 cases per 100,000 residents due to NFL and NCAA football games held with limited in-person attendance. Meaning This study suggests that NFL and NCAA games held with limited in-person attendance do not cause an increase in COVID-19 cases in the counties they are held.
Social media marketing in hospitality and tourism organisations

The main problem examined in this study was that many hospitality and tourism organisations have yet to fully integrate social media into their daily marketing activities in order to promote their products and services and enhance customer relationships. This qualitative research case study sought to identify and comprehend the factors contributing to this, as well as what marketing professionals believe can be done to drive hospitality and tourism organisations to consider social media in their marketing strategies. Data was collected through semi-structured interviews with seven social media marketing professionals in Cyprus. Key results highlight several factors that prevent hospitality and tourism organisations from integrating social media in their marketing activities, but also what marketing professionals believe can be done to overcome them. The findings helped to inform recommendations for future research as well as best practices that can be implemented by marketing professionals in hospitality and tourism organisations.
Emergency Department Treatment of Opioid Use Disorder

From 2005 to 2014, US drug-related emergency department (ED) visits doubled, and from 2016 to 2017, US ED visits for opioid overdoses increased by nearly 30%. More than one in twenty people treated in the ED for a nonfatal opioid overdose will die within one year of their ED visit. Although evidence-based and cost-effective treatments for opioid use disorder (OUD) exist, there are substantial gaps in access. EDs offer an ideal setting to address this treatment gap by initiating OUD treatment, facilitating linkage to outpatient treatment, and providing harm reduction services. ED-initiated buprenorphine followed by office-based referral has been demonstrated to increase treatment engagement and reduce illicit opioid use. People with untreated OUD who are not in withdrawal during their ED visit can be provided with a prescription for buprenorphine and instructions for unobserved initiation. In addition to receiving treatment, all the patients with OUD should be provided with harm reduction education and take-home naloxone. First-line treatments of acute pain in patients with OUD include continuing addiction treatment medications, adjusting dosages of medications for OUD, NSAIDs, regional nerve blocks, low-dose ketamine, and administering or prescribing additional opioid agonists when necessary, in coordination with outpatient treatment providers.
Pharmacodynamic study of axitinib in patients with advanced malignancies assessed with (18)F-3'deoxy-3'fluoro-L-thymidine positron emission tomography/computed tomography.

Purpose Rapid disease progression associated with increased tumor proliferation has been observed during withdrawal of anti-angiogenic therapy. We characterize the dynamics of withdrawal flare for axitinib.
Genetic control of yeast mannan structure. Isolation and characterization of mannan mutants.

Abstract The yeast Saccharomyces cerevisiae X2180, the strain most commonly used for genetic studies on yeasts, was treated with the mutagen ethyl methanesulfonate, and mutants defective in the synthesis of cell wall mannan were isolated. The initial selection of mutants was made on the basis of their failure to agglutinate with antiserum that was specific for the mannotetraose side chain of the mannan, the immuno-dominant group of this yeast strain, which has the structure αMan(1→3)αMan(1→2)αMan(1→2)Man. Nonagglutinating cells were assumed to have modified mannan structures, and this was confirmed by chemical analysis of the isolated mutant mannans. Two classes of mutants were obtained. One was apparently defective in the formation of the α-1→3-mannosyl-transferase (mnn1) which is presumed to be involved in the addition of the terminal α-1→3-linked mannose unit to form the mannotetraose side chain. The other class was defective in one of two α-1→2-mannosyltransferases that must be involved in adding the two α-1→2-linked mannose units, one of them (mnn2) directly to the α-1→6-linked mannose units in the backbone of the polysaccharide and the other (mnn3) to this first side chain mannose unit. No mutant was obtained that was defective in forming the backbone. Since such a mutation would yield a cell completely lacking mannan, it might be lethal. Complementation studies on diploid crosses of representatives of the different mutant classes gave results that were consistent with the interpretations based on chemical analysis of the mutant mannans. Thus, diploids obtained from crosses between mnn1 x mnn2, mnn2 x mnn3, or mnn1 x mnn3 mutants all made mannan of the X2180 chemotype. We conclude that all of the mutations involve structural genes for the various mannosyltransferases that are required for mannan synthesis and not regulatory genes that control expression of a particular mannan chemotype.
The effect of lexical predictability on eye movements in reading: Critical review and theoretical interpretation.

A word's predictability in its context has a reliable influence on eye movements in reading. This article reviews the extensive literature that has investigated this influence, focusing on several specific empirical issues. These include assessment of cloze probability as the critical measure of predictability, the form of the relationship between predictability and reading time, the distributional effects of predictability, the interaction between predictability and word frequency, and the interaction between predictability and parafoveal preview. On the basis of this review, two theoretical conclusions are proposed. First, predictability effects in reading result from graded activation of potentially many words, as opposed to discrete prediction of a specific word. Second, this activation has the effect of facilitating either very early stages of lexical processing or pre-lexical processing of visual features or letters.
CAENORHABDITIS ELEGANS Fertilization-Defective Mutants with Abnormal Sperm

Seven new fertilization-defective mutants of C. elegans have been isolated and characterized; six are temperature sensitive, one is absolute and all are autosomal recessive. One mutation is in a previously described gene, while the other six define six new fer genes that appear to code for sperm-specific functions necessary for normal fertilization. In all fer mutants, both males and hermaphrodites accumulate sperm in near normal numbers. In hermaphrodites, mutant sperm contact the oocytes, but fail to fertilize them. Instead, the sperm are swept into the uterus by the passing oocytes and are expelled when oocytes are laid. Males of two fer mutants do not transfer sperm during copulation, but the other mutant males transfer sperm that fail to move to the spermatheca. Spermatozoa from fer-1 and fer-4 mutants are motility-defective in vitro as well as in vivo, and their pseudopods have an altered morphology. The period of development during which mutant hermaphrodites are temperature sensitive for fertility overlaps the time of sperm development. Some mutants are temperature sensitive throughout the entire period, and others are temperature sensitive during or just prior to spermiogenesis. In fer-4/+ and fer-7/+ males, the fertility of the mutation-bearing sperm is diminished, reducing the transmission ratio. This implies some post-meiotic expression of these genes.--This set of mutants provides a variety of functional and structural alterations in nematode sperm that should help identify and analyze gene products involved in sperm morphogenesis and motility.
The Measuring, Mapping, and Meaning of Pots

The Folk Classification of Ceramics: A Study of Cognitive Prototypes. Willett Kempton. New York: Academic Press, 1981. xvi + 237 pp. $24.50 (cloth).
Measurement of Phase Transition Free Energies in Polyelectrolyte-Surfactant Complexes

When polyelectrolytes are mixed with oppositely charged surfactants at a 1:1 charge ratio, long-range ordered polyelectrolyte−surfactant complexes are formed. In this paper we demonstrate that by using the “Luzzati method” combined with osmotic stress measurements, we were able to determine the polyelectrolyte−surfactant free energy change while transitioning from a Pm3n cubic phase to a hexagonal phase. Assuming that the major contribution to this energy originates from bending energies associated with the structural rearrangements of the surfactants, we determined the bending modulus of the surfactant inside the complex.
Foam bezoar: resection of perforated terminal ileum in a 17-year-old with sickle β+ thalassemia and pica

Children and adolescents with sickle cell disease demonstrate an increased incidence of pica. Pica involving polyurethane foam has been previously reported, but effective management of such cases remains unclear. We present the case of a 17-year-old African American adolescent girl with sickle β+ thalassemia who presented with a long history of foam rubber pica resulting in intestinal obstruction. Conservative management was unsuccessful, and the patient ultimately required operative intervention. We advocate for a low threshold for early operation in cases of foam rubber bezoar.
Delayed accumulation of the yeast G1 cyclins Cln1 and Cln2 and the F‐box protein Grr1 in response to glucose

The ability to integrate nutrient availability into cell cycle regulation is critical for the viability of organisms. The Saccharomyces cerevisiae ubiquitin ligase SCF(Grr1) regulates the stability of several proteins that participate in cell division or nutrient sensing. Two of its targets, the cyclins Cln1 and Cln2, accumulate in the presence of glucose. When glucose is added to cells growing asynchronously, we show that the accumulation of the cyclins is a very slow response. We report that the F-box protein Grr1 also accumulates at higher levels in the presence of glucose, and that the response to glucose follows a delayed pattern strikingly similar to that described for Cln1 and Cln2. A model for the regulation of F-box proteins predicts that substrate accumulation could stabilize Grr1. While we found that Grr1 is more stable in cells growing with glucose, we show that the delayed responses to glucose occur independently: Grr1 accumulates in the absence of the cyclins, and vice versa. Thus, our results indicate that this model might not apply to the cyclins and Grr1. Glucose is known to strengthen the interaction of Grr1 with Skp1 in the SCF complex. We hypothesize that glucose could promote the accumulation of Grr1 and its assembly into a SCF complex as a feedback regulation that helps compensate for higher cyclins levels. Copyright © 2007 John Wiley & Sons, Ltd.
Transmission and expression of the parasitic paternal sex ratio (PSR) chromosome

B-chromosomes are often considered genomic parasites. They are extra to the normal chromosomal complement, are unnecessary for survival of an individual, and are often inherited at higher than Mendelian rates. Paternal Sex Ratio (PSR) is an extreme example of a parasitic B-chromosome in the wasp Nasonia vitripennis. It is transmitted via sperm but then destroys the other paternal chromosomes in the early fertilized egg. PSR disrupts the normal haplodiploid sex determination system of this wasp by converting diploid (female) eggs into haploid eggs that develop into PSR-bearing males. Transmission and expression of PSR was measured in single pair crosses between carrier males and standard females. Presence of the chromosome was detected by probing offspring with PSR-specific repetitive DNA. Most (equal to or more than 90 per cent) PSR males produced all-male offspring. Overall transmission rates of PSR to fertilized eggs varied beween 0.94 and 1.0. Some males (up to 10 per cent) produced daughters at varying frequencies. Of 226 daughters tested, only one carried PSR (and this may have been a laboratory error) indicating that daughters result from failure of transmission rather than loss of expression. Transmission of PSR to males in families that included female offspring varied from 0 to 94 per cent. Incomplete transmission is most likely the result of loss of PSR in some spermatogonial cell lineages and indicates some mitotic instability. Implications of the results to the aetiology and population genetics of PSR are discussed.
When graded domains are Schreier or pre-Schreier

We characterize, in terms of properties of homogeneous elements, when a graded domain is pre-Schreier or Schreier. As a consequence, the following properties of a commutative monoid domain A[M] are equivalent: (1) A[M] is pre-Schreier; (2) A[M] is Schreier; (3) A and M are Schreier. This is. in contrast to pre-Schreier monoids and pre-Schreier integral domains, which need not be Schreier.
Phagosomal proteins of Dictyostelium discoideum.

In recognizing food particles, Dictyostelium cell-surface molecules initiate cytoskeletal rearrangements that result in phagosome formation. After feeding D. discoideum cells latex beads, early phagosomes were isolated on sucrose step gradients. Protein analyses of these vesicles showed that the y contained glycoproteins and surface-labeled species corresponding to integral plasma membrane proteins. Cytoskeletal proteins a lso were associated with
Nutritional assessment and support of the patient with acute heart failure.

Purpose of review A significant number of patients hospitalized with heart failure are malnourished. Depletion of micronutrients, which is known to occur in heart failure for a variety of reasons, may contribute to myocardial abnormalities noted in heart failure. In this review, we focus on nutritional supplementation strategies that might improve myocardial performance and, as a consequence, decrease mortality and morbidity in these patients. Recent findings The available data suggest that micronutrient and macronutrient supplementation may play a role in improving the myocardial metabolic abnormalities noted in heart failure. A recent trial of omega-3 fatty acid macronutrient supplementation showed a modest decrease in mortality and hospitalizations when used in patients with New York Heart Association class II-IV heart failure. Summary Recommendations for nutritional support in patients with heart failure are difficult to make due to a lack of large randomized trials. Supplementation with omega-3 fatty acids, and micronutrients such as thiamine, coenzyme Q-10 and carnitine has shown promise in several studies. Since the data is not conclusive, large trials are needed to address whether these positive findings are reproducible in a wider subset of patients. In addition, these trials should study the combination of different micronutrients and macronutrients since heart failure patients are rarely deficient in just one micronutrient or macronutrient.
Relative Effects of Gaussian and Poisson Noise on Subjective Image Quality

Photographic transparencies were prepared with precisely determined quantities of gaussian (signal-independent) and Poisson (signal-dependent) noise and submitted to observers for subjective ranking of image quality. Average values of noise and signal-to-noise ratio, based upon the relative variance of the signal, were calculated for the imagery: (a) assuming equal a priori probabilities of allowed signal levels; (b) using a normalized probability density function for signal levels derived from scene statistics. Best correlation with the results of subjective quality ranking was obtained with an average signal-to-noise ratio based upon the normalized probability density function.
Information technology service management: an emerging area for academic research and pedagogical development

The economic landscape has changed for the industrialized nations of the world. The most mature nations on the planet have transitioned from agriculture and manufacturing economies to service-based economies. Services constitute more than 75% of industrialized nations' economies. These services are dependent on Information & Communication Technology that is supported by local and global information technology functions or the combination of both. In this paper, we review the modern methods and standards of information technology service management, such as ISO/IEC 20000; emerging pedagogical developments; and alternative approaches to ITSM research.
A computationally efficient model for turbulent droplet dispersion in spray combustion

A novel model for turbulent droplet dispersion is formulated having significantly improved computational efficiency in comparison to the conventional point source stochastic sampling methodology. In the proposed model, a computational parcel representing a group of physical particles is considered to have a normal (Gaussian) probability density function (PDF) in three-dimensional space. The mean of each PDF is determined by Lagrangian tracking of each computational parcel, either deterministically or stochastically. The variance is represented by a turbulence-induced mean squared dispersion which is based on statistical inferences from the linearized direct modeling formulation for particle/eddy interactions. Convolution of the computational parcel PDF's produces a single PDF for the physical particle distribution profile. The validity of the new model is established by comparison with the conventional stochastic sampling method, where in each parcel is represented by a delta function distribution, for non-evaporating particles injected into simple turbulent air flows.