cssi/SciSciGPT-SciSciNet huggingface dataset:
Interactive vs passive screen time and nighttime sleep duration among school-aged children

Background Insufficient sleep among school-aged children is a growing concern, as numerous studies have shown that chronic short sleep duration increases the risk of poor academic performance and specific adverse health outcomes. We examined the association between weekday nighttime sleep duration and 3 types of screen exposure: television, computer use, and video gaming.
INHIBITION OF CELL PROLIFERATION BY THE MAD1 TRANSCRIPTIONAL REPRESSOR

Mad1 is a basic helix-loop-helix-leucine zipper protein that is induced upon differentiation of a number of distinct cell types. Mad1 dimerizes with Max and recognizes the same DNA sequences as do Myc:Max dimers. However, Mad1 and Myc appear to have opposing functions. Myc:Max heterodimers activate transcription while Mad:Max heterodimers repress transcription from the same promoter. In addition Mad1 has been shown to block the oncogenic activity of Myc. Here we show that ectopic expression of Mad1 inhibits the proliferative response of 3T3 cells to signaling through the colony-stimulating factor-1 (CSF-1) receptor. The ability of over-expressed Myc and cyclin D1 to complement the mutant CSF-1 receptor Y809F (containing a Y-to-F mutation at position 809) is also inhibited by Mad1. Cell cycle analysis of proliferating 3T3 cells transfected with Mad1 demonstrates a significant decrease in the fraction of cells in the S and G2/M phases and a concomitant increase in the fraction of G1 phase cells, indicating that Mad1 negatively influences cell cycle progression from the G1 to the S phase. Mutations in Mad1 which inhibit its activity as a transcription repressor also result in loss of Mad1 cell cycle inhibitory activity. Thus, the ability of Mad1 to inhibit cell cycle progression is tightly coupled to its function as a transcriptional repressor.
Effects of storm-induced salinity changes on submersed aquatic vegetation in Kings Bay, Florida

Hurricanes and other major storms cause acute changes in salinity within Florida's streams and rivers. Winddriven tidal surges that increase salinities may have long-lasting effects on submersed aquatic vegetation (SAV) and the associated fauna. We investigated potential effects of salinity pulses on SAV in Kings Bay, Florida, by subjecting the three most common macrophytes,Vallisneria americana, Myriophyllum spicatum., andHydrilla verticillata, to simulated salinity pulses. In Kings Bay, we documented changes in salinity during three storms in September 2004 and measured biomass and percent cover before and after these storms. During experiments, macrophytes were exposed to salinities of 5‰, 15‰, or 25‰ for 1, 2, or 7 d, with a 28-d recovery period in freshwater. Relative to controls, plants subjected to salinities of 5‰ exhibited few significant decreases in growth and no increase in mortality. All three species exhibited decreased growth in salinities of 15‰ or 25‰.H. verticillata, exhibited 100% mortality at 15‰ and 25‰, irrespective of the duration of exposure.M. spicatum andV. american exhibited increased mortality after 7-d exposures to 15‰ or any exposure to 25‰ Maximum daily salinities in Kings Bay approached or exceeded 15‰ after each of the three storms, with pulses generally lasting less than 2 d. Total aboveground biomass and percent cover of vascular plants, were reduced following the storms.M. spicatum exhibited an 83% decrease in aboveground biomass and an 80% decrease in percent cover.H. verticillata exhibited a 47% and 15% decline in biomass and percent cover, respectively.V. americana, exhibited an 18% increase in aboveground biomass and a 37% increase in percent cover, which suggests greater tolerance of salinity pulses and release from competition with the invasiveH. verticillata andM. spicatum. Our results indicate that rapid, storm-induced pulses of high salinity can have important consequences for submersed aquatic vegetation, restoration efforts, and management of invasive species.
FOXO3–NF-κB RelA Protein Complexes Reduce Proinflammatory Cell Signaling and Function

Tumor-associated myeloid cells, including dendritic cells (DCs) and macrophages, are immune suppressive. This study demonstrates a novel mechanism involving FOXO3 and NF-κB RelA that controls myeloid cell signaling and impacts their immune-suppressive nature. We find that FOXO3 binds NF-κB RelA in the cytosol, impacting both proteins by preventing FOXO3 degradation and preventing NF-κB RelA nuclear translocation. The location of protein–protein interaction was determined to be near the FOXO3 transactivation domain. In turn, NF-κB RelA activation was restored upon deletion of the same sequence in FOXO3 containing the DNA binding domain. We have identified for the first time, to our knowledge, a direct protein–protein interaction between FOXO3 and NF-κB RelA in tumor-associated DCs. These detailed biochemical interactions provide the foundation for future studies to use the FOXO3–NF-κB RelA interaction as a target to enhance tumor-associated DC function to support or enhance antitumor immunity.
50-MILLIBAR PATTERNS AND THEIR RELATIONSHIP TO TROPOSPHERIC CHANGES

Abstract Data from three recent winters are utilized to study the large changes in the temperature and flow fields at 50 mb. It is reasoned that the major changes in this region arise from the development of an unstable flow pattern through the radiational cooling of air in polar regions. An analysis of tropospheric changes during periods of major activity at 50 mb indicates that the tropospheric circulation can be influenced by the developments in the upper stratosphere.
Extranodal NK/T-Cell Lymphoma, Nasal Type, Presenting as a Breast Mass

Extranodal natural killer/T-cell lymphoma, nasal type, is a rare type of non-Hodgkin cell lymphoma endemic to East Asia and parts of Central and South America. In most cases, it is driven by Epstein-Barr virus infections, with a broad range of morphologic appearances, frequent necrosis, and angioinvasion. It is designated as NK/T reflecting uncertainty in its cellular origins. These tumors usually arise in the nasal region, typically presenting with symptoms of nasal obstruction, epistaxis, and/or a destructive mass involving the nose, sinuses, or palate. The treatment of patients with extranodal NK/T-cell lymphoma, nasal type, is largely determined by the extent of disease. Localized disease is usually treated with radiation and chemotherapy. The disseminated disease requires combination chemotherapy. This report describes the case of a 30-year-old Caucasian female presenting with a left breast mass of two months duration. Excisional biopsy was done, and the pathological exam confirmed the diagnosis of extranodal NK/T-cell lymphoma, nasal type. Our patient received a systemic combination chemotherapy with steroid (dexamethasone), methotrexate, ifosfamide, L-asparaginase, and etoposide (SMILE) regimen, resulting in a complete clinical and radiological remission. On the basis of our review of the literature, extranodal NK/T non-Hodgkin cell lymphoma, nasal type, presenting as a breast mass is very rare and very uncommon in the United States. Awareness of this occurrence may be valuable as this case may be a forerunner of additional similar cases developing in the future.
Using ink to expose students' thought processes in CS2/CS7

This paper presents and discusses a web-based software tool called GraphPad designed to facilitate interactivity in a CS2 or CS7 (data structures) course in which Tablet PCs or WACOM tablets are available. We describe how GraphPad enables an instructor to: establish a temporary network with the instructor's Tablet as server and the students' Tablets as clients, broadcast instructions and collect student Ink responses, evaluate student submissions and distribute evaluations with a single button-click, use student submissions as examples to guide lecture, and save student submissions in a database. The saved submissions may then be reviewed individually, tagged for errors, and analyzed statistically. An immediate goal is to use GraphPad to deliver CS2/CS7 course content more effectively. A long term goal is to use data collected by GraphPad to help understand the thought process of the CS2/CS7 student for the purpose of identifying students at risk early in order to provide intervention assistance.
A Framework for Public Health Surveillance

With the rapid growth of social media, there is increasing potential to augment traditional public health surveillance methods with data from social media. We describe a framework for performing public health surveillance on Twitter data. Our framework, which is publicly available, consists of three components that work together to detect health-related trends in social media: a concept extraction component for identifying health-related concepts, a concept aggregation component for identifying how the extracted health-related concepts relate to each other, and a trend detection component for determining when the aggregated health-related concepts are trending. We describe the architecture of the framework and several components that have been implemented in the framework, identify other components that could be used with the framework, and evaluate our framework on approximately 1.5 years of tweets. While it is difficult to determine how accurately a Twitter trend reflects a trend in the real world, we discuss the differences in trends detected by several different methods and compare flu trends detected by our framework to data from Google Flu Trends.
A Configurable Energy-Efficient Compressed Sensing Architecture With Its Application on Body Sensor Networks

The past decades have witnessed a rapid surge in new sensing and monitoring devices for well-being and healthcare. One key representative in this field is body sensor networks (BSNs). However, with advances in sensing technologies and embedded systems, wireless communication has gradually become one of the dominant energy-consuming sectors in BSN applications. Recently, compressed sensing (CS) has attracted increasing attention in solving this problem due to its enabled sub-Nyquest sampling rate. In this paper, we investigate the quantization effect in CS architecture and argue that the quantization configuration is a critical factor of the energy efficiency for the entire CS architecture. To this end, we present a novel configurable quantized compressed sensing (QCS) architecture, in which the sampling rate and quantization are jointly explored for better energy efficiency. Furthermore, to combat the computational complexity of the configuration procedure, we propose a rapid configuration algorithm, called RapQCS. According to the experiments involving several categories of real biosignals, the proposed configurable QCS architecture can gain more than 66% performance-energy tradeoff than the fixed QCS architecture. Moreover, our proposed RapQCS algorithm can achieve over $150\times$ speedup on average, while decreasing the reconstructed signal fidelity by only 2.32%.
Abstract 34: Endogenous Superoxide Dismutase Protects From Impaired Generation of Activated Protein C and Enhanced Susceptibility to Experimental Thrombosis in Mice

In vitro studies have suggested that reactive oxygen species such as superoxide can produce prothrombotic effects, including enhanced platelet activation, increased tissue factor (TF) expression, and an oxidative modification in thrombomodulin impairing its capacity to enhance the generation of activated protein C (APC) by thrombin. It is not known, however, if elevated levels of superoxide accelerate susceptibility to experimental thrombosis in vivo . We used mice genetically deficient in superoxide dismutase-1 (SOD1, an antioxidant enzyme that dismutates superoxide to hydrogen peroxide), to test the hypothesis that lack of SOD1 enhances susceptibility to thrombosis. Susceptibility to carotid artery thrombosis in a photochemical injury model demonstrated that Sod1-/- mice formed stable occlusions significantly faster than Sod1+/+ mice (P<0.05). In an inferior vena cava (IVC) stasis model Sod1- /- mice developed significantly larger thrombi 48 hours after IVC ligation (P<0.05 vs. Sod1+/+ mice). After activation with thrombin (0.5 U/ml) or convulxin (200 ng/ml), no differences in surface expression of P-selectin or binding of fibrinogen were observed between platelets from Sod1-/- and Sod1+/+ mice. The expression of TF mRNA in lung measured by real time qPCR showed similar levels in Sod1-/- and Sod1 +/+ mice. However, the activation of exogenous protein C by thrombin in lung homogenates was decreased in Sod1 -/- mice (P<0.05 vs. Sod1 +/+ mice). Further, in vivo generation of activated protein C in response to thrombin (40 U/Kg) infusion was significantly lower in Sod1-/- mice (P<0.05 vs. Sod1+/+ mice). No differences in mRNA levels for thrombomodulin or endothelial protein C receptor were detected in Sod1 -/- mice vs. Sod1 +/+ mice, suggesting that altered generation of activated protein C in Sod1-/- mice may be related to a direct oxidative effect on thrombomodulin. In accordance, thrombomodulin treated with xanthine/hypoxanthine showed 40% loss of ability to activate protein C that was overcome by addition of SOD and catalase (P<0.05). We conclude that endogenous SOD1 in mice protects from impaired generation of activated protein C and accelerated thrombosis.
In vitro safety assessment of double-stranded polynucleotides poly I:C and Mu-9.

SummaryThe double-stranded RNA's poly I:C (rIn:rCn) and Mu-9 ds RNA, which are potent inducers of interferon, did not affect the rate of growth, did not prevent the development of senescence, and did not cause detectable alteration of the karyotype of human diploid fibroblast cell line HFL-1B when present in single or in serial passage. Additionally, the cells propagated in the presence of the RNA's did not become neoplastic as determined by assay in the cheek pouch of cortisone-treated hamsters.
Painful small fiber neuropathies.

Purpose of review This article reviews the clinical features, pathophysiology, and treatment of small fiber sensory neuropathy. Recent findings Neuropathic pain is prevalent among patients with peripheral neuropathies of diverse etiologies. For example, in one recent study using the sensitive Neuropathic Pain Symptom Inventory as a screening tool, neuropathic pain was reported in 94% of patients with different peripheral nervous system diseases. Neuropathic pain is frequently underrecognized or inadequately treated. Furthermore, the paucity of clinical signs with small fiber neuropathy may delay recognition of an organic process. Pain, or uncomfortable symptoms, typically results from damage to small unmyelinated nerve fibers (C fibers) or thinly myelinated nerve fibers (A delta fibers). Recent research has helped discover the location of the "pain generators" within the injured peripheral nerves. Small fiber neuropathies are relatively common in clinical practice, but until recently most of the available neurodiagnostic tests focused on large caliber nerve fibers. In the past two decades, the widespread use of quantitative sensory testing and punch skin biopsies to evaluate small caliber nerve fibers has substantially changed the neurologist's ability to diagnose and manage small fiber sensory neuropathy. Summary Neuropathic pain from small fiber neuropathy is prevalent and is caused by a wide variety of disorders, many of which are treatable, especially if recognized early in the process.
Slow search

Seeking to enrich the search experience by allowing for extra time and alternate resources.
Hormonal treatment at time of radical retropubic prostatectomy for stage D1 prostate cancer.

AbstractWe classified 70 prostatic cancers as stage D1 at the time of pelvic lymphadenectomy and radical prostatectomy. For retrospective analysis after 1 to 14 years of followup, the patients were divided into 32 in whom endocrine therapy had been given immediately postoperatively and 38 in whom it had not. These 2 groups did not differ substantially in patient age, Gleason grade, pathologic stage, tumor volume or seminal vesicle involvement. The mean number of involved nodes per patient was higher in the hormone-treated group (2.9 versus 1.8).According to Kaplan-Meier projections 88 per cent of such patients without hormonal treatment will have progression within 5 years, compared to only 14 per cent of those given hormonal treatment immediately. However, projected survival differed little between the groups, most likely since 17 of the 18 patients with progression in the nontreated group were given hormonal treatment as soon as progression was substantiated.Definitive assessment of the impact of the ti...
Wide-Field Retinal Imaging of Retinal and Choroidal Tumors

Wide-field imaging is important in the field of ocular oncology. This technology allows a panretinal image that includes tumor margins and relationships to surrounding structures with imaging of associated features and, most importantly, allows for accurate planning of tumor therapy. Several tumors in the eye arise from the retina, retinal pigment epithelium (RPE), choroid, and optic disc. Some of these tumors are benign and others are malignant. Wide-field imaging, in conjunction with other diagnostic testing, has improved our understanding of ocular tumors and provided better documentation of tumor appearance and effects. In this chapter, we provide images of intraocular tumors with various wide-field cameras.
Opportunities for increasing CO2 storage in deep, saline formations by active reservoir management and treatment of extracted formation water: Case study at the GreenGen IGCC facility, Tianjin, PR China

Abstract Carbon capture, utilization and storage (CCUS) seeks beneficial applications for CO 2 recovered from fossil fuel combustion. This study evaluated the potential for removing formation water to create additional storage capacity for CO 2 , while simultaneously treating the produced water for beneficial use. The process would control pressures within the target formation, lessen the risk of caprock failure, and better control the movement of CO 2 within that formation. The project plans to highlight the method of using individual wells to produce formation water prior to injecting CO 2 as an efficient means of managing reservoir pressure. Because the pressure drawdown resulting from pre-injection formation water production will inversely correlate with pressure buildup resulting from CO 2 injection, it can be proactively used to estimate CO 2 storage capacity and to plan well-field operations. The project studied the GreenGen site in Tianjin, China where Huaneng Corporation is capturing CO 2 at a coal fired IGCC power plant. Known as the Tianjin Enhanced Water Recovery (EWR) project, local rock units were evaluated for CO 2 storage potential and produced water treatment options were then developed. Average treatment cost for produced water with a cooling water treatment goal ranged from 2.27 to 2.96 US$/m 3 (recovery 95.25%), and for a boiler water treatment goal ranged from 2.37 to 3.18 US$/m 3 (recovery 92.78%). Importance analysis indicated that water quality parameters and transportation are significant cost factors as the injection-extraction system is managed over time. The study found that in a broad sense, active reservoir management in the context of CCUS/EWR is technically feasible. In addition, criteria for evaluating suitable vs. unsuitable reservoir properties, reservoir storage (caprock) integrity, a recommended injection/withdrawal strategy and cost estimates for water treatment and reservoir management are proposed.
Covalent Surface Modification of Gallium Arsenide Photocathodes for Water Splitting in Highly Acidic Electrolyte

Efficient water splitting using light as the only energy input requires stable semiconductor electrodes with favorable energetics for the water-oxidation and proton-reduction reactions. Strategies to tune electrode potentials using molecular dipoles adsorbed to the semiconductor surface have been pursued for decades but are often based on weak interactions and quickly react to desorb the molecule under conditions relevant to sustained photoelectrolysis. Here, we show that covalent attachment of fluorinated, aromatic molecules to p-GaAs(1 0 0) surfaces can be employed to tune the photocurrent onset potentials of p-GaAs(1 0 0) photocathodes and reduce the external energy required for water splitting. Results indicate that initial photocurrent onset potentials can be shifted by nearly 150 mV in pH -0.5 electrolyte under 1 Sun (1000 W m-2 ) illumination resulting from the covalently bound surface dipole. Though X-ray photoelectron spectroscopy analysis reveals that the covalent molecular dipole attachment is not robust under extended 50 h photoelectrolysis, the modified surface delays arsenic oxide formation that results in a p-GaAs(1 0 0) photoelectrode operating at a sustained photocurrent density of -20.5 mA cm-2 within -0.5 V of the reversible hydrogen electrode.
Pain and its Assessment in Herpes Zoster

Pain typically accompanies acute herpes zoster. In a proportion of patients, herpes zoster pain persists well beyond rash healing. This persisting pain is termed post-herpetic neuralgia (PHN). Beca...
Mitochondrial Fluctuations as a Measure of Biomechanical Properties of Murine Cells

Introduction: The active mechanical properties of the cellular cytoskeleton are important in a number of significant cellular processes from migration to cell division, and are altered in cancer. A non-invasive single-cell assay of these properties would be of significant value for understanding these cellular processes, would give insights into mechanical heterogeneity between cells, and would be of therapeutic importance in cancer. A promising technique is derived from passive particle microrheology, wherein fluorescent beads are inserted into the cytoplasm, their mean square displacement (MSD) measured, and mechanical parameters calculated using viscoelastic theory. The non-invasive version of this method uses mitochondrial fluctuations towards the same goal which is potentially a very useful assay due to its relative simplicity. Methods: We carried out a detailed study of mitochondrial fluctuations in the C3H-10T1/2 cell line, a murine embryonic mesenchymal cell line, as well as two osteosarcoma cell lines with low and high metastatic potentials, DUNN and DLM8. Cells were cultured under standard growth condition for 24 hr, and then stained with MitoTracker Green FM (ThermoFisher Scientific). Random cells were selected for imaging using spinning disk confocal microscopy at a high temporal resolution (100 ms per frame) for 100 s. We optimized a multi-step image processing protocol to identify mitochondria with high fidelity. We selected the mitochondria with life-time spanning the entire imaging period and with no interaction with other mitochondria and calculated the MSD. Results: The MSD of isolated mitochondria resembles that of a particle in a viscoelastic medium, in agreement with previous results. However comparison of MSD between controls and cells treated with drugs that disrupt the actin and microtubule network showed surprisingly small effects, while treatment with ATP synthesis inhibitors significantly decreased the MSD. Our results imply that mitochondrial fluctuations are primarily driven by active fluctuations of the cytoskeleton, and are relatively unaffected by perturbing the actin or microtubule network, at least in the cell lines in our study. Comparison of MSDs between less invasive and more invasive murine osteosarcoma cells showed significant differences at long time scales. Hence active fluctuations differ significantly between different cell types. We also observed significant heterogeneity among cells of the same type and even more heterogeneity in the mitochondria from a single cell. Our analysis suggests that mitochondrial fluctuations reflect the active contractile properties of the cytoskeleton.
Appropriateness of Outpatient Echocardiograms Ordered by Pediatric Cardiologists or Other Clinicians.

Objective To assess the appropriateness and diagnostic yield of TTEs ordered by various pediatric providers according to the pediatric appropriate use criteria (AUC) for outpatient transthoracic echocardiography (TTE) before its release. Study design Clinic notes of patients aged ≤18 years who underwent initial outpatient TTE between April and September 2014 were reviewed to determine the AUC indication, and appropriateness was assigned based on the AUC document. Ordering physicians were categorized into cardiologists, primary care physicians (PCPs; including pediatricians and family practitioners [FPs]), and noncardiology subspecialists. Results Of the 1921 TTEs ordered during the study period, 84.6% were by cardiologists, 9.2% by pediatricians, 3.4% by FPs, and 2.8% by noncardiology subspecialists. The appropriateness rate for cardiologists was higher than that for PCPs (86% vs 64%; P P = .80). PCPs had a significantly higher proportion of studies that could not be classified compared with cardiologists (35% vs 5%; P P P Conclusions Compared with PCPs, cardiologists ordered more TTEs, had the highest yield of abnormal findings, and had greater appropriateness of TTE orders. A large proportion of TTEs ordered by PCPs were unclassifiable owing to insufficient information. This study lays a framework for provider education and improvement in the TTE order intake process.
A new integrative data mining framework for analyzing the cancer genome atlas data

Besides accuracy and efficiency, understandability is another key issue of predictive modeling in real-world applications, especially in biomedical and healthcare data analysis. We develop a new integrative framework to enhance the interpretability of data by sparsity-based learning. We proposed several novel sparsity-based learning models, emphasizing different understandable properties of data, such as explicit sparsity, low redundancy, and low rank, and apply to The Cancer Genome Atlas (TCGA) data analysis. Results indicate that the proposed methods provide more insights from TCGA data while maintaining stable and competitive performances in predictive modeling. To further enhance the interpretability of biological processes and disease mechanisms, we also develop a novel visualization tool by considering heterogeneous relationships among genomics elements. By applying the novel learning models and the visualization tools, pathways of several important cancer diseases are revisited and a series of novel potential bio-markers are discovered which improves our ability to diagnosis, treat and prevent cancer.
Investigation of the sensitivity of functional near-infrared spectroscopy brain imaging to anatomical variations in 5- to 11-year-old children

Functional near-infrared spectroscopy (fNIRS) is a noninvasive brain imaging technique that uses scalp-placed light sensors to measure evoked changes in cerebral blood oxygenation. The portability, low overhead cost, and ability to use this technology under a wide range of experimental environments make fNIRS well-suited for studies involving infants and children. However, since fNIRS does not directly provide anatomical or structural information, these measurements may be sensitive to individual or group level differences associated with variations in head size, depth of the brain from the scalp, or other anatomical factors affecting the penetration of light into the head. This information is generally not available in pediatric populations, which are often the target of study for fNIRS. Anatomical magnetic resonance imaging information from 90 school-age children (5 to 11 years old) was used to quantify the expected effect on fNIRS measures of variations in cerebral and extracerebral structure. Monte Carlo simulations of light transport in tissue were used to estimate differential and partial optical pathlengths at 690, 780, 808, 830, and 850 nm and their variations with age, sex, and head size. This work provides look-up tables of these values and general guidance for future investigations using fNIRS sans anatomical information in this child population.
Proceedings of the 35th annual ACM/IEEE international symposium on Microarchitecture

On behalf of the MICRO organizing committee, we are very pleased to welcome you to Istanbul, Turkey, for the 35th Annual IEEE/ACM International Symposium on Microarchitecture (MICRO-35). Istanbul is a jewel of a city, combining the magnificent historical treasures of past civilizations with the life of a modem metropolis.Over the years, MICRO has proved itself to be the premier technical forum on microarchitecture, and this year is no exception: MICRO-35 will feature outstanding keynote speeches by Tilak Agerwala (Vice President, Systems, IBM Research) and by Justin R. Rattner (Intel Fellow and Director, Microprocessor Research, Intel Labs). The MICRO-35 technical program, as usual, will be of very high quality. This year, we had 150 papers submitted (another record for MICRO), out of which 36 were accepted. MICRO-35 includes six tutorials on exciting topics of current interest: asynchronous and partially asynchronous microprocessor design, thermal management in microprocessors, compilation for the Itanium, network processors, and microarchitecture simulation tools. There will also be four cutting-edge workshops on the topics of EPIC architectures and compilers, media and stream processors, multithreading, and application-specific processors.We have encouraged students to attend MICRO-35 and to submit papers. We created a new Student Advocate position this year with the goal of ensuring that we are providing the right opportunities for the students who will become the next generation of researchers in our field. We are very grateful to Haldun Hadimioglu for serving in this position. We will be offering many travel grants for students and junior faculty, thanks to the generous support MICRO-35 has received this year. There will also be best student paper and best student presentation awards in MICRO-35's technical program. The ACM and IEEE have graciously agreed to provide free memberships to the award-winning student authors.
«By Tray, Scraper and Prokhodnushka»: Prospector’s Gold Mining Development in the Magadanskiy Sovnarhoz in 1957–1962s

The author analyzes dynamics of prospector’s gold mining in the Magadanskiy sovnarhoz per 1957–1962s. It has taken the important place in regional structure of gold mining. During 1957–1959 years there was an organizational becoming artels of prospectors. The cost price of prospector’s gold was more cheaply, than on the state extraction. Regional committees of Communist party have rendered very essential support in prospector’s activity in the end of 1950 th. However party bodies have begun the company on restriction of earnings and toughening of the control over prospectors work.
Weakly convergent sequences of Banach space valued random variables

Examples are constructed of sequences {Xn} of E valued random variables such that (a) for each x* e E*, x*(Xn) → 0 a.s. and yet (b) Xn does not go to zero weakly a.s.
Carney's complex in a patient with hormone-producing Sertoli cell tumor of the testicle.

AbstractCarney’s complex is an unusual disorder consisting of a variety of endocrinological and urological manifestations. The characteristic gonadal and adrenal features of Carney’s complex should become familiar to urologists. A patient was evaluated for obesity, cushingoid features, hyperlipidemia, glucose intolerance, coronary artery disease, a left adrenal mass, bilateral testicular masses and cardiac myxomas. Pathological evaluation revealed the testicular tumors to be of Sertoli cell origin, the adrenal mass to be an adrenocortical adenoma and intracardiac lesions consistent with myxomas. The features of Carney’s complex are discussed.
Estimates of fish and coral larvae as nutrient subsidies to coral reef ecosystems

Nutrient subsidies are essential for the functioning of many ecosystems. A long‐standing conundrum in coral reef ecology is how these systems can be among the most productive globally, but persist in nutrient‐poor conditions. Here, we investigate the importance of the larvae of fishes and corals and gametes of corals as nutrient subsidies for coral reefs. We provide evidence that fish larvae may be an ecologically important source of exogenous nutrients. We found that at the high end of mean estimates of fish larval supply rates, larvae can replace the nutrients in the entire fish community (estimated from Caribbean coral reefs) in 28 and 434 d for nitrogen (N) and phosphorus, respectively. Coral larvae, on the other hand, appear to represent only a fraction of the nutrients supplied by the larval fish community. In contrast, coral gametes provide substantial pulses of recycled nutrients during synchronous spawning events. Within a single night, gametes from coral spawning events can produce nutrient fluxes that represent 13 and 64 times the amount of N and carbon, respectively, stored in coral reef fish communities. Our analysis suggests that larvae and/or gametes of fishes and corals may represent an important, but previously underappreciated, source of nutrients to coral reefs that warrant inclusion into models of nutrient dynamics and ecosystem function.
The Effects of Changing Sex Roles on Male Homosexuals

Any chapter dealing with male homosexuals’ roles needs to begin with the caution that the population studied is anything but clearly defined. For instance, one report1 indicates that different individuals with similar sexual histories describe themselves variously as heterosexual, bisexual, and homosexual. The male hustler who presents himself as “straight” because he only permits the gay to fellate him, or only inserts in the “fag,” is well documented.2 It is important in counseling to remember that homosexual acts neither cause nor define one’s sexual orientation. The simplest definition is “one who has an affectional or sexual preference for a person of the same sex.” For some helping professionals, an individual with no same-sex experiences but regular fantasies would be called homosexual; for others, only two individuals of the same sex who set as a mutual goal getting each other to climax would be involved in a homosexual act. Enough males respond sexually to pressure on the genitals or other external stimulation that it almost seems as if intent should be part of the definition, as Bieber3 recommended in 1962. Whether one uses the individual’s self-definition, or an outsider’s count of frequency of the behavior (e.g., the Kinsey4 data that 10% are primarily homosexual for at least three years in their postadolescent lives), it seems clear that there are vast numbers of American males who see themselves as gay, fear that they may be homosexual, or merely indulge in some same-sex activity as occasion presents itself, without thought of a label. For mental health workers, it is important to recognize that some self-definitions are merely “homosexual panic,” but a thorough review of the individual’s developing sexuality usually helps. Some adolescents wonder about being homosexual, but the vast majority of gay males “knew” by the time they were in their teens.5’6
Explicit and Implicit Contracts with Non-Financial Stakeholders and Corporate Capital Structure: The Case of Product Warranties

We use a unique dataset of product warranty offerings by firms to investigate the effect of a firm’s warranty reserve levels on its capital structure decisions. Our sample consists of firms that (i) offer explicit warranties, (ii) likely offer implicit product warranties, and (iii) are in non-warranty-offering industries. For the whole sample, we find that leverage relates negatively to the firm’s warranty level. Further, we find that firms that offer implicit warranties have lower debt levels than firms in non-warranty industries and that, conditional on operating in a warranty-offering industry, firms that issue explicit warranties tend to have even lower debt levels. We also investigate the determinants of the product warranty decision, and find that firms offer explicit warranties when products are more differentiated, when uncertainty about product quality is high, and when sellers have private information on product quality. We then show that the negative relation between firm’s debt and warranty levels continues to hold even after we control for self-selection by firms into offering explicit warranties. Our research contributes to the literature that examines how contracting with non-financial stakeholders such as customers affects the firm’s financing decision.
Providing Health Care Professionals and Patients with Tablet Computers at the Point of Care.

The University of Connecticut (UConn) Health Sciences Library, part of the UConn Library System, is located at the UConn Health Center in Farmington, CT. This library supports all health sciences i...
Superiorly located midline cervical cleft

Abstract Midline cervical cleft (MCC) is a rare congenital anomaly presumed to be caused by failed fusion of branchial arches. This anomaly is typically found in the ventral neck where it causes a cosmetic defect and potential cervical contracture. Here we describe an isolated superiorly located MCC found just inferior to the lower lip in a 6-year-old male. To our knowledge, this is the first description of an isolated MCC in this location. The child was taken to the operating room for surgical excision of the lesion with primary closure yielding an excellent outcome.
Faculty Orientation to Off-Campus and International Campus Locations.

AbstractFollowing in the same tradition of seamlessly providing access to library resources to our remote users, our campus has now taken the next logical step in also providing an orientation for ...
Experimental Demonstration of an Ultrabroadband Nonlinear Cloak for Flexural Waves

Broadband cloaking of flexural waves is a major challenge since the governing equation is not form invariant under coordinate transformations. We fabricate a flexural cloaking structure using only a single material composed of homogeneous and isotropic layers, and then present experimental evidence of the first near-ideal broadband cloak in thin plates. The 3D-printed structure is shown to effectively disguise an object over a broad frequency range (2 kHz--11 kHz). The proposed cloak has potential applications in shielding sensors and sensitive components from vibrations in bridges, automobiles, and aircraft.
Resting regional brain activity correlates of verbal learning deficit in major depressive disorder.

Abstract Memory deficits are reported in major depressive disorder (MDD). Prefrontal cortical and mesiotemporal cortical (MTC)/subcortical regions are involved in the Buschke Selective Reminding Task (SRT), a verbal list-learning task. To determine whether depression-related changes in resting brain metabolism explain (in part) the deficits in SRT performance found in MDD, statistical correlation maps were calculated between SRT total recall score (TR) and relative regional cerebral metabolic rate for glucose (rCMRglu), measured by [18F]-flourodeoxyglucose (FDG) positron emission tomography (PET), in unmedicated, depressed MDD patients (N = 29). Subsequently, to explore hypothesized loss of top-down control in MDD, we compared the correlations between rCMRglu of SRT-relevant regions of the dorsolateral prefrontal cortex (dlPFC) and amygdala in a larger cohort of MDD (N = 60; 29 inclusive) versus healthy controls (HC) (N = 43). SRT performance of patients is on average 0.5 standard deviation below published normative mean. TR and rCMRglu positively correlate in bilateral dorsomedial PFC, dlPFC, dorsal anterior cingulate; negatively correlate in bilateral MTC/subcortical regions, and cerebellum. rCMRglu in dlPFC correlates negatively with that in amygdala in HC but not in MDD. Depression-related changes present in FDG-PET measured resting brain activity may be in part responsible for memory deficit found in MDD.
Carbon nanotube/carbon composite fiber with improved strength and electrical conductivity via interface engineering

Abstract Carbon nanotube/carbon (CNT/C) composites show potential for lightweight structural materials and non-metal electrical conductors for aerospace, military, and other industries where the combination of lightweight, high strength and excellent conductivity are required. Most research attempts have been reported to fabricate CNT/C composite focusing on the high CNT alignment and dense carbon matrix. However, simultaneous improvement of strength and electrical conductivity in materials still presents a great challenge. In this study, pyrolyzed polydopamine (py-PDA) with selected surface treatments is introduced as an interface enhancer between CNTs and the carbon matrix. Due to the presence of py-PDA, the effective physical interlocking and conductive pathways are rebuilt at the interface area between CNTs and carbon matrix, resulting in better load transfer and electron transport. The CNT/py-PDA/C composite fibers demonstrated remarkable improvements in electrical conductivity (2.1 × 103 S cm−1 or 228 S m2 kg−1) and tensile strength (up to 727 MPa or 790 MPa/(g·cm−3)), which should prove to be vastly advantageous as compared to the previously reported CNT/C composites. The outstanding thermal stability of fully carbonized materials is also an attractive feature. Coupled with scalable manufacturing methods, these integrated characteristics of CNT/py-PDA/C composite fiber can potentially have broad applications for lightweight structural materials and non-metal conductors.
Physiological responses and enjoyment of Kinect-based exergames in older adults at risk for falls: A feasibility study.

BACKGROUND Exergaming has the potential to improve physical function, cognition and dual-task function, and could be an effective new strategy for reducing risk of falling in older adults. OBJECTIVE To evaluate and test custom Microsoft Kinect-based motion-tracking exergames in older adults at risk for falls. METHODS Community-dwelling older adults who reported mobility difficulties or had fallen in the past year played three newly developed exergames (Target Trackers, Double Decision, and Visual Sweeps, 5 minutes each) in random order. Heart rate (HR) was measured during, and blood pressures (BPs), rating of perceived exertion (RPE), and rating of the enjoyment were recorded immediately after each exergame. RESULTS Seven participants (median age 75 y; 4 females) completed the study. There were no adverse events reported during the exergaming session. Exercise HRs and RPEs were statistically significantly higher than resting for all exergames (p< 0.05). The differences were not significant for BPs. Enjoyment ratings ranged from 79.6-90.6% and there were no statistically significant differences between the exergames. CONCLUSIONS The newly developed exergames were light in exercise intensity and enjoyable for older adults at risk for falls. Future intervention studies are warranted to examine the benefits of exergames for this special population.
Private Label Products and Consumer Income: Is There a Curvilinear Relationship?

Supermarket scanner data are analyzed for five product categories across three income groups to test the premise of a curvilinear relationship between income and private labels (PLs). The three income groups are lower–, moderate–, and higher-income consumers and the premise tested is that moderate-income consumers are far more inclined to purchase PLs than lower– and higher– income consumers. The five product categories selected for this study are: butter and margarine; frozen potatoes; ice cream; jams, jelly and peanut butter; and yogurt. Statistical results derived for these product categories offer no support for a curvilinear relationship between income and PLs. Lower-income consumers are shown to be more prone to purchase PLs than moderate– and higher-income consumers across all product groups.
Perceptions of Program Directors Concerning Design and Implementation of the Master of Music Degree in Music Education

The key research question for this qualitative study was as follows: How do program directors in selected schools describe the successes and challenges related to the design of their Master of Musi...
Coordination-Induced N-H Bond Weakening in a Molybdenum Pyrrolidine Complex: Isotopic Labeling Provides Insight into the Pathway for H2Evolution

The synthesis and characterization of a cationic molybdenum pyrrolidine complex are described that exhibits significant coordination-induced N–H bond weakening. The N–H bond dissociation free energ...
Exploring the host-Guest interaction in tourism crisis communication

The purpose of this study was to explore the host–guest interaction in tourism crisis communication. Guided by a practice-based approach, our study used the recent event of the 2018 Florida Red Tid...
Distributed Bias Detection in Cyber-Physical Systems

An attacker can effectively publish false measurements in distributed cyber-physical systems with noisy measurements. These biased false measurements can be impossible to distinguish from noise and enable the attacker to gain a small but persistent economic advantage. The residual sum, a fundamental measurement of bias in cyber-physical systems, is employed to develop a detection scheme for bias attacks. The scheme is highly efficient, privacy preserving and effectively detects bias attacks.
The Grade-Level and Cumulative Outcomes of Absenteeism.

Nationally representative data from the Early Childhood Longitudinal Study Kindergarten Class of 2011 (n = 14,370) were used to examine the grade-level and cumulative outcomes of school absenteeism between kindergarten and fifth grade for students' school performance in the United States. Students who were more frequently absent in any year of elementary school demonstrated lower academic, executive function, and socioemotional outcomes. Although there was little variation in the magnitude of associations across grade levels, there was evidence of cumulative associations. Specifically, students who were consistently absent throughout elementary school tended to have lower outcomes across developmental domains in the long-term. The negative links between absenteeism and outcomes were larger for Black than White students, but few other subgroup differences emerged.
A review of heat-pipe modeling and simulation approaches in nuclear systems design and analysis

Abstract Nuclear systems are increasingly being designed to operate autonomously with passive safety systems and resilient, robust components. Heat-pipes naturally fit these requirements and are being investigate for use in advanced nuclear systems. These technologies were conceived and designed for this purpose but, recently, have become widely used and are known for use in electronic systems. The modern approach to nuclear safety involves full understanding of the physics at play. It is also important to predict the progression of the accidents from reactor steady-state to the point where either failure occurs or normal operation can be resumed. Understanding the speed of computation, the information obtained, the failures of various models are crucial to determining accurate accident progression. The history of heat-pipes in nuclear systems is reviewed as well as the modeling and simulation performed in that period. Various classes of models are reviewed analyzing their performance, capabilities, and draw backs when performing simulations.