cssi/SciSciGPT-SciSciNet huggingface dataset:
Fast Times and Digital Literacy: Participation Roles and Portfolio Construction within Instant Messaging:

The purpose of this study was to develop an understanding of adolescent use of instant messaging. Grounded in the New Literacy Studies stance that literacy is a social practice embedded in local contexts and informed by global ideologies (Street, 1995), I argue that participation in digital literacies such as instant messaging has implications for how wired youth are being prepared for participation in today's society. By using cultural historical activity theory and the activity system (Engestrom, 1987a; Engestrom & Middleton, 1996; University of Helsinki Center for Activity Theory and Developmental Work Research, n.d.) as the unit of analysis, I posit that instant messaging provides a space for participation in the roles of text producer, consumer, and distributor. Drawing on Gee's (2000a, 2000c, 2000d) descriptions of fast capitalism and shape-shifting portfolio people, I suggest that the 3 text roles contribute to the participant's portfolio or collection of attributes, achievements, and skills that c...
Operating leverage, financial leverage, and equity risk

Abstract The analysis investigates the combined leverage effect of a fixed capacity decision (fixed cost) plus debt on the risk of equity returns. It is argued that the traditional DOL-DFL calculation is incorrect. A correct calculation is given, using the fact that the capacity decision is endogenous to the firm's decision process. The analysis reveals that the capacity decision partially offsets the effect on equity risk of increasing business risk or debt. However, this ability is lost at high levels of debt.
A Quick Method of Preparing Permanent Fin‐Ray and Spine Sections

(1955). A Quick Method of Preparing Permanent Fin-Ray and Spine Sections. The Progressive Fish-Culturist: Vol. 17, No. 4, pp. 192-192.
Optical, Electronic, and Structural Properties of Uncoupled and Close-Packed Arrays of InP Quantum Dots

Solid films consisting of close-packed arrays of InP quantum dots have been prepared by slowly evaporating colloidal solutions of InP quantum dots. The diameters of the quantum dots were controlled to be between about 30 to 60 A; size-selective precipitation yielded a size distribution of about 10% about the mean diameter. The arrays show regions of hexagonal order, as well as disordered regions. Oxide layers can form irreversibly on the quantum dot surface and limit the effectiveness of the size-selective precipitation. Photoluminescence spectra obtained from close-packed films of InP quantum dots formed from quantum dots with a single mean diameter and from a mixture of two quantum dot sizes show that energy transfer occurs from the photoexcited smaller quantum dots to the larger quantum dots. The efficiency of this energy transfer process is high.
Neighborhood Collective Efficacy and Dimensions of Diversity: A Multilevel Analysis

Collective efficacy is becoming an increasingly important concept within the social and health sciences as researchers question how the social environment of a neighborhood influences a host of ind...
A new class of modular broadband arrays based on Gosper islands and associated Peano-Gosper curves

This paper investigates the radiation characteristics of a new type of array that is based on the family of space-filling and self-avoiding fractals known as Peano-Gosper curves. The elements of the fractal array are uniformly distributed along a Peano-Gosper curve, which leads to a planar array configuration with parallelogram cells that is bounded by a closed Koch curve. These unique properties are exploited in order to develop a design methodology for deterministic arrays that have no grating lobes even when the minimum spacing between elements is increased to at least one-wavelength. This leads to a class of arrays that are relatively broadband when compared to more conventional periodic planar arrays with square or rectangular cells and regular boundary contours. An efficient iterative procedure for calculating the radiation patterns of these Peano-Gosper fractal arrays to arbitrary stage of growth P will also be presented.
Potassium content of single human red cells measured with an electron probe.

The potassium content of single human red cells was measured with an electron probe. Cells were placed on beryllium discs and coated with a thin layer of dibutyl pthalate to prevent loss of cellular contents. Samples were stable under the electron beam during analysis for more than 15 minutes and could be stored for long periods of time. Primary standards were prepared by loading red cells with varying known amounts of potassium in order to circumvent the corrections for absorption. The X-ray intensity was found to be directly proportional to the potassium content of the cells.
Immune Unresponsiveness to Secondary Heterologous Bacterial Infection after Sepsis Induction Is TRAIL Dependent

Sepsis is the leading cause of death in most intensive care units, and patients who survive the hyperinflammation that develops early during sepsis later display severely compromised immunity. Not only is there apoptosis of lymphoid and myeloid cells during sepsis that depletes these critical cellular components of the immune system, but also the remaining immune cells show decreased function. Using a cecal-ligation and puncture (CLP) model to induce intra-abdominal polymicrobial peritonitis, we recently established a link between the apoptotic cells generated during sepsis and induction of sepsis-induced suppression of delayed-type hypersensitivity. The present study extends this earlier work to include a secondary heterologous bacterial infection (OVA257-expressing Listeria monocytogenes [LM-OVA]) subsequent to sepsis initiation to investigate sepsis-induced alterations in the control of this secondary infection and the associated naive Ag-specific CD8 T cell response. We found that CLP-treated wild-type (WT) mice had a reduced ability to control the LM-OVA infection, which was paralleled by suppressed T cell responses, versus sham-treated WT mice. In contrast, CLP-treated Trail−/− and Dr5−/− mice were better able to control the secondary bacterial infection, and the Ag-specific CD8 T cell response was similar to that seen in sham-treated mice. Importantly, administration of a blocking anti-TRAIL mAb to CLP-treated WT mice was able to restore the ability to control the LM-OVA infection and generate Ag-specific CD8 T cell responses like those seen in sham-treated mice. These data further implicate TRAIL-dependent immune suppression during sepsis and suggest TRAIL neutralization may be a potential therapeutic target to restore cellular immunity in septic patients.
Accuracy of float testing for metered-dose inhaler canisters

Objective To characterize and evaluate canister floating patterns of three commercially available metered-dose inhalers (MDIs) with varying amounts of medication remaining. Design Four canisters each of three asthma medications were studied. MDIs were actuated every 30 seconds to 60 seconds, and canisters were weighed and floated at 100%, 75%, 66%, 50%, 33%, 25%, 10%, and 0% of remaining labeled actuations. Position of the canisters and percentage submersion in water were recorded. Setting Controlled laboratory. Results We observed differences among the products with regard to canister floating behavior at varying levels of fullness. All canisters were completely submerged with the nozzle up at two-thirds full and greater. The canisters remained nozzle-up and were submerged to varying levels at the half-full point. When observed at less than half full, canisters inverted and floated nozzle down. Positions of the canisters varied among products at less than half full. No canister was fully tilted when all labeled actuations were used. Conclusion Float characteristics are product-specific and a function of canister size, design, content, and method of testing. Clinicians and asthma educators should not advise patients to use a float test to assess the amount of medication remaining in an MDI. Recommendations from the National Asthma Education and Prevention Program of the National Heart, Lung, and Blood Institute suggest that the only reliable method for determining the number of doses remaining in a canister is to subtract the number of doses used from the number available.
Words as Tools: Learning Academic Vocabulary as Language Acquisition

There is a growing awareness of the importance of academic vocabulary, and more generally, of academic language proficiency, for students’ success in school. There is also a growing body of research on the nature of the demands that academic language places on readers and writers, and on interventions to help students meet these demands. In this review, we discuss the role of academic vocabulary within academic language, examine recent research on instruction in academic vocabulary, considering both general academic words and discipline-specific words, and offer our perspective on the current state of this research and recommendations on how to continue inquiry and to improve practice in this area. We use the metaphor of ‘words as tools’ to reflect our understanding that instruction in academic vocabulary must approach words as means for communicating and thinking about disciplinary content, and must therefore provide students with opportunities to use the instructed words for these purposes as they are learning them.
TOTAL SYNTHESIS OF BREVETOXIN A : PART 2 : SECOND GENERATION STRATEGY AND CONSTRUCTION OF EFGH MODEL SYSTEM

Dissection at the ring F oxocene of brevetoxin A formed the basis of the second generation strategy for the total synthesis of this molecule. In this case the planned hydroxy ketal cyclization was successful, and selective reduction of the resulting product gave the EFGH ring system of the target molecule.
Observation of piezoelectricity in free-standing monolayer MoS2

Free-standing monolayers of MoS2 exhibit piezoelectric behaviour due to inversion symmetry breaking. Piezoelectricity allows precise and robust conversion between electricity and mechanical force, and arises from the broken inversion symmetry in the atomic structure1,2,3. Reducing the dimensionality of bulk materials has been suggested to enhance piezoelectricity4. However, when the thickness of a material approaches a single molecular layer, the large surface energy can cause piezoelectric structures to be thermodynamically unstable5. Transition-metal dichalcogenides can retain their atomic structures down to the single-layer limit without lattice reconstruction, even under ambient conditions6. Recent calculations have predicted the existence of piezoelectricity in these two-dimensional crystals due to their broken inversion symmetry7. Here, we report experimental evidence of piezoelectricity in a free-standing single layer of molybdenum disulphide (MoS2) and a measured piezoelectric coefficient of e11 = 2.9 × 10–10 C m−1. The measurement of the intrinsic piezoelectricity in such free-standing crystals is free from substrate effects such as doping and parasitic charges. We observed a finite and zero piezoelectric response in MoS2 in odd and even number of layers, respectively, in sharp contrast to bulk piezoelectric materials. This oscillation is due to the breaking and recovery of the inversion symmetry of the two-dimensional crystal. Through the angular dependence of electromechanical coupling, we determined the two-dimensional crystal orientation. The piezoelectricity discovered in this single molecular membrane promises new applications in low-power logic switches for computing and ultrasensitive biological sensors scaled down to a single atomic unit cell8,9.
High-Temperature Rheological Properties of Asphalt Binders

Previous research efforts have shown that the rutting parameter used in the performance grade asphalt binder specifications, |G*|/ sin δ, does not reasonably predict the rutting potential of asphalt mixtures, especially when modified binders are used. A number of other parameters, such as the zero shear rate viscosity and the permanent strain accumulated under repeated creep and recovery, were investigated; however, no consensus was achieved. This paper investigates the use of zero shear rate viscosity and of repeated creep permanent strain as potential specification parameters and discusses the importance of temperature susceptibility and of strain tolerance to the rut resistance of asphalt binders.
The Hereditary Periodic Fever Syndromes: Molecular Analysis of a New Family of Inflammatory Diseases

The hereditary periodic fever syndromes are a group of Mendelian disorders characterized by episodic fever and serosal or synovial inflammation. Familial Mediterranean fever (FMF) and the hyperimmunoglobulinemia D and periodic fever syndrome are both recessively inherited, while three dominantly inherited syndromes have been described, the best-characterized of which is familial Hibernian fever (FHF). The last year has seen two major developments in this field: the FMF gene was identified on chromosome 16p by positional cloning, and a second major periodic fever locus was mapped to distal chromosome 12p. The FMF gene (MEFV) encodes a novel 781 amino acid protein; to date, eight different missense mutations and a number of polymorphisms have been described. Seven of the eight mutations occur within a region of 82 amino acids near the C-terminus. Computational analysis of the conceptual protein reveals five different domains/motifs compatible with a nuclear effector function. MEFV is expressed preferentially in granulocytes and myeloid bone marrow precursors, giving rise to speculation that the protein may serve as a transcriptional regulator of inflammation in granulocytes. The second periodic fever locus was mapped by two different groups: one studying FHF, the other studying a similar dominantly inherited syndrome designated familial periodic fever. Both genes map to the same 19 cM region on distal chromosome 12p, strongly suggesting a common locus. The molecular characterization of the periodic fever genes should provide important new insights into the regulation of inflammation in general.
Understanding Potential Exposure Sources of Perfluorinated Carboxylic Acids in the Workplace

This paper integrates perspectives from analytical chemistry, environmental engineering, and industrial hygiene to better understand how workers may be exposed to perfluorinated carboxylic acids when handling them in the workplace in order to identify appropriate exposure controls. Due to the dramatic difference in physical properties of the protonated acid form and the anionic form, this family of chemicals provides unique industrial hygiene challenges. Workplace monitoring, experimental data, and modeling results were used to ascertain the most probable workplace exposure sources and transport mechanisms for perfluorooctanoic acid (PFOA) and its ammonium salt (APFO). PFOA is biopersistent and its measurement in the blood has been used to assess human exposure since it integrates exposure from all routes of entry. Monitoring suggests that inhalation of airborne material may be an important exposure route. Transport studies indicated that, under low pH conditions, PFOA, the undissociated (acid) species, actively partitions from water into air. In addition, solid-phase PFOA and APFO may also sublime into the air. Modeling studies determined that contributions from surface sublimation and loss from low pH aqueous solutions can be significant potential sources of workplace exposure. These findings suggest that keeping surfaces clean, preventing accumulation of material in unventilated areas, removing solids from waste trenches and sumps, and maintaining neutral pH in sumps can lower workplace exposures.
Speeding up string matching over compressed text on handheld devices using tagged sub-optimal code (TSC)

Tagged suboptimal code (TSC) is a new coding technique presented in this paper to speed up string matching over compressed databases on PDAs. TSC is a variable-length suboptimal code that supports minimal prefix property. It always determines its codeword boundary without traversing a tree or lookup table. TSC technique may be beneficial in many types of applications: speeding up string matching over compressed text, speeding decoding process, as well as any general-purpose integer representation code. Experimental results show that TSC is 8.9 times faster than string matching over compressed text using Huffman encoding, and 3 times faster in the decoding process. On the other hand, the compression ratio of TSC is 6% less than that of Huffman encoding. Additionally, TSC is 14 times faster than byte pair encoding (BPE) compression process, and achieves better performance than searching over compressed text using BPE scheme on handheld devices.
Sailplane carry-through structures made with composite materials

The carry-through structure, which joins and transmits loads between aircraft wings and fuselage, is a box-and-beam configuration made from composite materials hi the RP series of all-composite sailplanes. Increases hi the size and weight of these aircraft increased the complexity of their carry-through structures. RP-1 has an interference- fit, box-and-beam configuration that was repeated in RP-2, but it failed during static testing because of peeling of the box capstrips at about 95% of design load. Because of this failure, the RP-2 carry through was redesigned with clearance between the box and beam and with phis transferring the bending loads: this redesign was adopted and modified for RP-3. The RP-1, RP-2, and RP-3 carry throughs and associated flight-worthiness tests are presented here and their implications for aircraft design with composite materials are discussed.
Wide Speed Range Inverter

The literature has documented well the characteristics of many different types of inverter circuits. One such circuit is described in detail. A brief theory of operation is given, together with the reasons for choosing this particular circuit and some of the advantages and disadvantages accruing to its use. Finally, a number of optional features will be described which are available to allow the customer to "tailor" a basic inverter to his particular application.
A new robust optimization approach for scheduling under uncertainty: I. Bounded uncertainty

The problem of scheduling under bounded uncertainty is addressed. We propose a novel robust optimization methodology, which when applied to mixed-integer linear programming (MILP) problems produces “robust” solutions which are in a sense immune against bounded uncertainty. Both the coefficients in the objective function, the left-hand-side parameters and the right-hand-side parameters of the inequalitie s are considered. Robust optimization techniques are developed for two types of uncertain data: bounded uncertainty and bounded and symmetric uncertainty. By introducing a small number of auxiliary variables and constraints, a deterministic robust counterpart problem is formulated to determine the optimal solution given the (relative) magnitude of uncertain data, feasibility tolerance, and “reliability level” when a probabilis tic measurement is applied. The robust optimization approach is then applied to the scheduling under uncertainty problem. Based on a novel and effective continuous-time short-term scheduling model proposed by Floudas and coworkers [Ind. Eng. Chem. Res. 37 (1998a) 4341; Ind. Eng. Chem. Res. 37 (1998b) 4360; Ind. Eng. Chem. Res. 38 (1999) 3446; Comp. Chem. Engng. 25 (2001) 665; Ind. Eng. Chem. Res. 41 (2002) 3884; Ind. Eng. Chem. Res. (2003)], three of the most common sources of bounded uncertainty in scheduling problems are addressed, namely processing times of tasks, market demands for products, and prices of products and raw materials. Computational results on several small examples and an industrial case study are presented to demonstrate the effectiveness of the proposed approach. © 2003 Elsevier Ltd. All rights reserved.
Unrolling Roles in Techno-Pedagogy: Toward New Forms of Collaboration in Traditional College Settings.

Taking the rapid development of information technologies as a catalyst for re-examining the roles generally assigned to professors, students, librarians, and technology support staff in traditional college settings, this article explores how these players in higher education can collaborate to redefine their roles. The article begins with a theoretical exploration of our concept of role and then describes a workshop designed to explore how roles are defined and played out in academic settings.
Modelling C3 photosynthesis from the chloroplast to the ecosystem

Globally, photosynthesis accounts for the largest flux of CO2 from the atmosphere into ecosystems and is the driving process for terrestrial ecosystem function.The importance of accurate predictions of photosynthesis over a range of plant growth conditions led to the development of a C3 photosyn- thesis model by Farquhar, von Caemmerer & Berry that has become increasingly important as society places greater pres- sures on vegetation. The photosynthesis model has played a major role in defining the path towards scientific understand- ingofphotosyntheticcarbonuptakeandtheroleofphotosyn- thesis on regulating the earth's climate and biogeochemical systems. In this review, we summarize the photosynthesis model,including its continued development and applications. We also review the implications these developments have on quantifying photosynthesis at a wide range of spatial and temporal scales, and discuss the model's role in determining photosynthetic responses to changes in environmental condi- tions. Finally, the review includes a discussion of the larger- scale modelling and remote-sensing applications that rely on the leaf photosynthesis model and are likely to open new scientificavenuestoaddresstheincreasingchallengestoplant productivity over the next century.
Front spreading on 3D surfaces

We present a method for simulating front propagation over 3D surfaces with arbitrary topology. Our approach, which can handle the simultaneous spreading of multiple fronts, is implemented by applying a level set method on the surface. A special data structure, called the surrounding grid, assists in advancing the fronts without triangulation or parameterization of the surface. The surrounding grid consists of discretized grid points in the vicinity of the surface. An enhanced distance field provides the bridge between the surrounding grid and the surfaces on which the fronts travel. By manipulating speed functions in the level set method, the front propagation dynamics can be conveniently controlled. We illustrate the applicability and flexibility of our method with three example applications: texture generation, water flooding, and fire propagation.
Evaluation of Single Phase Flow in Microchannels for High Flux Chip Cooling: Thermohydraulic Performance Enhancement and Fabrication Technology

The increased circuit density on today’s computer chips is reaching the heat dissipation limits for air-cooled technology. Direct liquid cooling of chips is being considered as a viable alternative. This paper reviews liquid cooling in terms of technological options and challenges. The possibilities presented herein indicate a four-to ten-fold increase in heat flux over the air-cooled systems. The roadmap for single-phase cooling technology is presented to identify research opportunities in meeting the cooling demands of future IC chips. The use of three-dimensional microchannels that incorporate either microstructures in the channel of grooves in the channel surfaces may lead to enhancement in single-phase cooling. A simplified fabrication process is described that can build both classes of three-dimensional microchannels. Proof-of-concept microchannels are presented to demonstrate the efficacy of the fabrication process.Copyright © 2004 by ASME
The relationship between circulating 25-hydroxyvitamin D and survival in newly diagnosed advanced non-small-cell lung cancer

Serum 25-hydroxyvitamin D [25(OH)D], the major circulating form of vitamin D used for evaluating the vitamin D status of patients, has been associated with survival in a variety of cancers with conflicting evidence. We aimed to investigate this association in newly diagnosed advanced non-small-cell lung cancer (NSCLC) patients. This was a consecutive cohort of 359 newly diagnosed stages III-IV NSCLC patients who underwent a baseline serum 25(OH)D evaluation prior to receiving any treatment at our institution between January 2008 and December 2010. We used the vitamin D categories of “deficient ( = 20 ng/ml)”. Cox regression was used to evaluate the prognostic significance of serum 25(OH)D after adjusting for relevant confounders. Mean age at diagnosis was 57.4 years. Of the 359 patients, 151 (42.1 %) were deficient in vitamin D at the time of diagnosis. The median survival in deficient and not deficient cohorts was 11.7 and 12.8 months respectively (p = 0.06). Season of diagnosis, performance status, smoking status and hospital location significantly predicted vitamin D status. On univariate Cox analysis, gender, stage of disease, hospital location, histologic subtype, subjective global assessment (SGA), performance status, smoking status, body mass index and serum albumin were significantly associated with survival (p <0.05 for all). On multivariate Cox analysis, six variables demonstrated statistically significant associations with survival: stage of disease, hospital location, histologic subtype, SGA, smoking status and serum albumin (p <0.05 for all). Serum vitamin D, which was borderline significant in univariate analysis, lost its significance in multivariate analysis. We found season of diagnosis, performance status and smoking history to be predictive of vitamin D status. Consistent with previously published research in advanced NSCLC, we did not find any significant association between pre-treatment serum 25(OH)D and survival in our patients.
Carcinogenesis by Cancer Chemotherapeutic Agents: Second Malignancies Complicating Hodgkin’s Disease in Remission

It has been long known that in some types of malignant disease there exists an associated propensity to develop other malignant tumors. Acute leukemia complicating the course of polycythemia vera and the increased incidence of skin cancer in chronic lymphocytic leukemia are well known (Modan, 1965; Hyman, 1969). It has remained enigmatic whether the disease renders the host more likely to develop second tumors or whether the therapy itself in certain settings, is capable of inducing genetic changes which subsequently lead to malignant degeneration. The importance of second tumor induction emerges only if the patient with advanced disease can survive, with treatment, long enough to increase his risk. This is especially true in the atomic bomb radiation induced leukemias where a latent period of over 5 years was required before an increased incidence of leukemia was noted (Bizzozero et al., 1966).
Complex Event Extraction using DRUM

Complex mechanisms, such as cell-signaling pathways, consist of many highly interconnected components, yet they are often described in disconnected fragmentary ways. The goal of DRUM (Deep Reader for Understanding Mechanisms) is to develop a system that can read papers and combine results of individual studies into a comprehensive explanatory model. A first step is to automatically extract relevant events and event relationships from the literature. This paper describes initial steps in extending an existing general deep language understanding system, TRIPS, to read biomedical papers. In a preliminary evaluation, our system was the best performing system among the participants, achieving results close to human expert performance. These results suggested that our system is viable for complex event extraction and, ultimately, understanding complex systems and mechanisms.
CHARGE-EXCHANGE COUPLING IN $sup 98$Mo + p REACTIONS.

The presence of isospin coupling in the incident channel is observed as anomalous behavior in $^{98}\mathrm{Mo}$+$p$ excitation functions for proton, deuteron, and triton outgoing channels. Similarly shaped anomalies are simultaneously observed in several channels at threshold energies for the ($p, n$) reaction to the ground-state analog and to excited-state analogs of $^{98}\mathrm{Mo}$. The latter imply coupling through a deformation of the isospin-dependent potential.
Multi-material additive manufacturing of antennas

In this presentation we will describe several different antenna technologies fully fabricated using multi-material additive manufacturing. We will show that combining standard fused deposition modelling with micro-dispensing printing enables us to realize mechanically robust antenna systems that contain spatially variable dielectric and magnetic properties and intricate 3D conducting networks.
The Effects of Acute and Chronic Ethanol Exposure on GABAergic Neuroactive Steroid Immunohistochemistry: Relationship to Ethanol Drinking

Abstract Neuroactive steroids are endogenous steroids that rapidly alter neuronal excitability primarily at γ-aminobutyric acid type A (GABA A ) receptors. Immunohistochemical techniques have allowed for the visualization of 3α-hydroxy-5α-pregnan-20-one (3α,5α-THP) distribution and regulation by ethanol in brain sections from various animal models. In rats, acute ethanol administration leads to significant alterations in neuroactive steroids in various brain regions, including hippocampal increases and amygdalar reductions in 3α,5α-THP levels. Neuroactive steroids appear to influence ethanol drinking in various animal models of excessive drinking, though different effects are found in various mouse strains and rat models. Local increases in 3α,5α-THP in the ventral tegmental area of rats reduce ethanol self-administration. Chronic intermittent ethanol exposure in mice produces decreases in 3α,5α-THP immunoreactivity in various cortical and limbic subregions as well as increases in subregions of the hippocampus. Similarly, chronic ethanol administration in nonhuman primates reduces amygdalar 3α,5α-THP levels, which are negatively correlated with drinking behavior. Evidence indicates that neuroactive steroids influence many of the GABAergic effects of ethanol in vivo and contribute to sensitivity to the behavioral effects of ethanol. Thus, neuroactive steroids may be a target for therapeutic interventions for alcohol use disorders.
Suburbanizing the City

Abstract Urban planners and city officials have considered various strategies to lure the middle class back to the central city — including urban renewal programs and historic preservation. A neglected alternative is to build suburban style housing downtown. Residents of a ranch-style condominium development in downtown Indianapolis were asked about their backgrounds, reasons for moving, and reactions to their new neighborhood. The results were compared with similar data from two nearby historic districts. Suburban style housing seems to draw new types of people downtown — e.g., wealthier, less skilled at exterior repairs, previously living a little further out from the city center. It seems unsuccessful in attracting young couples with children, however, and the prospects for duplicating this type of project on a large scale seem limited Recent buyers of historic homes expressed less initial satisfaction with their neighborhoods, but the presence of restoration activity was important in stimulating the t...
DEFINITE STENT THROMBOSIS: DOES HIGH DENSITY LIPOPROTEIN CHOLESTEROL LEVEL MATTER?

Low HDL- cholesterol (c) appears to be an independent predictor of platelet-dependent thrombus formation. We sought to study the role of HDL-c in the development of definite stent thrombosis (ST). We retrospectively examined percutaneous coronary intervention (PCI) database at our large academic
Differences Between the Normal Serum Protein Patterns of American Indian, Negro and Caucasian Subjects

SummarySerum protein analyses of 3 ethnic groups (American Indian, Negro and Caucasian) revealed the following differences: 1. Indian and Negro subjects have a lower percentage of albumin and a higher percentage of beta and gamma globulins than do Caucasians. 2. Indian subjects have a higher percentage of alpha 1 globulin and a lower percentage of alpha 2 globulin than do Caucasians and Negroes.
Growth, fruiting and ethylene binding of tomato plants in response to chronic ethylene exposure

Summary‘Red Robin’ tomato plants were grown in chambers containing 0, 0.01, 0.05 or 0.1 µl l−1 ethylene in the atmosphere. Plants in 0.05 or 0.1 µl l−1 ethylene had epinastic leaves. At 0.01 µl l−1 ethylene, visual symptoms were difficult to detect unless an untreated plant was used as a comparison. Even the smallest tested concentrations of ethylene reduced fruit numbers. Plant height of this dwarf tomato variety was not greatly affected by ethylene exposure. Plants exposed to any concentration of ethylene had almost double the ethylene binding capacity of plants grown in ethylene-free air. When plants growing in air were treated with diazocyclopentadiene, an ethylene binding site inhibitor, shoot fresh weight increased, but plant height did not. Thus, endogenous ethylene plays little to no role in determining plant height in this variety.
The butterfly proboscis as a fiber-based, self-cleaning, micro-fluidic system

The butterfly proboscis is a unique, naturally engineered device for acquiring liquid food, which also minimizes concerns for viscosity and stickiness of the fluids. With a few examples, we emphasize the importance of the scale-form functionality triangle of this feeding device and the coupling through capillarity.
Systemic Transcriptional Alterations of Innate and Adaptive Immune Signaling Pathways in Atherosclerosis, Ischemia Stroke, and Myocardial Infarction.

Background: Transcriptional profiles are available for a variety of cardiovascular-related diseases. The goal of this study was to compare blood transcriptional profiles of the Toll-like receptor (TLR), T-cell receptor (TCR), and B-cell receptor (BCR) signaling pathways in asymptomatic atherosclerosis, acute ischemic stroke, and myocardial infarction patients to identify common mechanisms of immune regulation and their association with epigenetic regulation. Methods and results: Peripheral blood gene expression profiles from human atherosclerosis-related diseases and healthy controls were downloaded from Gene Expression Omnibus (GEO). Genes in the TLR, TCR, and BCR pathways were retrieved from the NCBI BioSystems database. Significance of gene enrichment and concordance of expression changes in each pathway was compared between studies. Gene expression was significantly correlated across the three disease conditions (p<10-15) and the proportion of significant genes was high (30~60%, p<0.001). Hub genes identified by weighted gene co-expression network analysis (WGCNA) in the TCR/BCR sub-network, including CD81 and TCR-CD3ζ, were significantly down-regulated and highly correlated with DNA (cytosine-5-)- methyltransferase 1 (DNMT1). Conclusion: Common biologically relevant networks associated with immune regulation in stroke, atherosclerosis, and myocardial infarction were discovered. Given the high correlation of DNMT1 with these immune signaling pathways, epigenetic regulation may contribute to the coordination of innate and adaptive immune response in all CVD disease states. Down-regulation of the TCR-BCR axis in the adaptive immune system offers critical information for the investigation of the functional mechanisms underlying chronic inflammation-induced immune suppression in cardiovascular disease and stroke.
Efficacy and Safety of Oral Fosfomycin for Urinary Tract Infections in Hospitalized Patients.

Ed. Note: The authors of the original article (Sastry et al.) declined to respond. We read with interest the paper by Sastry and colleagues ([1][1]) showing high clinical success using fosfomycin to treat urinary tract infections (UTIs) in inpatients. We recently evaluated the use of oral
Effects of Methylphenidate and Atomoxetine on Cortical Inhibition in ADHD

The effects of methylphenidate (MPH), a psychostimulant, and atomoxetine (ATX), a selective norepinephrine reuptake inhibitor, on short interval-cortical inhibition (SICI) were measured in motor cortex with transcranial magnetic stimulation, in a study at Cincinnati Children’s Medical Center, OH, and other centers.
Teaching qualitative research methods using Undercover Boss

Course(s): Research Methods, Qualitative Research Methods, Organizational Communication, Business CommunicationObjectives: After completing this class exercise, students should be able to identify the major components of a qualitative research study, along with the ethical dilemmas that come with doing qualitative research.
Cold-inducible RNA-binding protein (CIRP) causes sepsis-associated acute lung injury via induction of endoplasmic reticulum stress

Cold-inducible RNA-binding protein (CIRP) causes sepsis-associated acute lung injury via induction of endoplasmic reticulum stress
Zukunftsthema Video- und Online-Beratung

In dem abschliesenden Kapitel dreht sich alles um die Umsetzungsaspekte, die Ihnen helfen sollen, das Gelesene auf Ihre individuelle Situation zu beziehen. Ziel ist, dass Sie einen personlichen Umsetzungsplan erstellen. Dazu formulieren Sie Ihre konkrete Positionierung aus, integrieren die Video- und Online-Beratung in Ihr bisheriges Angebotsportfolio und schliesen bezuglich Ihrer Online-Beratungskompetenz etwaige Kompetenzlucken. Wichtig ist: Sie erarbeiten sich anhand der zehn Gesprachsphasen, die Sie in Schritt 3 kennengelernt haben, einen Gesprachsleitfaden, den Sie fur Ihre ersten Online-Kontakte nutzen.
“We Talked About Sex.” “No, We Didn't”: Exploring Adolescent and Parent Agreement About Sexuality Communication

ABSTRACTFamily communication about sex can protect adolescents from risky behavior, like early sex and sex without protection. However, adolescents and parents often disagree about whether they talked with each other about sexual issues, limiting the protective effects of communication. Few studies explore these disagreements. This study included 27 pairs of early adolescents and parents. Adolescent and parent interviews were coded for agreement in reports of sexuality communication. Adolescents’ interview themes were compared across levels of agreement between adolescent–parent dyads. Adolescents who highly agreed with their parents were more likely than those who did not to describe positive parental approaches to sexuality communication and awareness of parental perspectives, while no group differences were found for responses to parents’ viewpoints. Study findings highlight the importance of sex education programs that support adolescent–parent sexuality communication, particularly for middle school s...
Named entity linking of geospatial and host metadata in GenBank for advancing biomedical research.

GenBank is a popular National Center for Biotechnology Information (NCBI) database for submission and analysis of DNA sequences for biomedical research. The resource is part of the Entrez environment which enables for cross-linking of concepts and entries in other participating NCBI databases such as Taxonomy, PubMed and Protein. For example, a GenBank record of an influenza A hemagglutinin gene DNA sequence might have a link to the Taxonomy database for the organism, a link to the related article in PubMed (if published) and a link to the Protein entry for the hemagglutinin protein. Despite its importance in biomedical research such as population genetics, phylogeography and public health surveillance, the host and geospatial metadata of genetic sequences in GenBank are not linked to any database. Therefore, to facilitate biomedical research based on georeferenced DNA sequences and/or DNA sequences with normalized host names, we designed and developed a framework that enriches GenBank entries by linking their host metadata to the NCBI Taxonomy database and their geospatial metadata to a comprehensive knowledge base of geographic locations called GeoNames. Here, we introduce a database created through the application of this framework to virus sequences in GenBank, and evaluate our normalization algorithms on a set of manually annotated records pertaining to viruses. Although currently applied to viruses, our framework can be easily extended to other organisms, and we discuss the potential utilization of our resource for biomedical research. Database URL: https://zodo.asu.edu/zoophydb/
Initial Management of the Trauma Patient in Maxillofacial Surgery

Oral maxillofacial surgeons must be integral members of the trauma team. With the unique skill sets of this specialty, OMFS is a certain critical participant in the initial evaluation and management of patients with multiple injuries, particularly with critical issues such as a difficult airway due to injuries involving the head and neck, massive hemorrhage from these areas, and threatened vision loss. Although definitive repair of injuries within the area of OMFS generally does not occur until several days past the resuscitation of the critically injured, early participation of the oral and maxillofacial surgeon in optimal care of trauma victims promotes a more thorough understanding of the complex pathophysiology that may adversely affect perioperative preparation for these cases. Moreover, familiarity with recent advances in resuscitation of shock following trauma prepares the surgeon for catastrophic bleeding that may occasionally complicate OMFS. Fundamental knowledge of cardiovascular physiology, a detailed understanding of the coagulation system, and appreciation for the intricate pathways and delicate balance of homeostasis provide an arguably necessary scientific foundation for safe and effective surgical practice of any specialty.
Localization of migraine susceptibility genes in human brain by single-cell RNA sequencing:

BackgroundMigraine is a debilitating disorder characterized by severe headaches and associated neurological symptoms. A key challenge to understanding migraine has been the cellular complexity of t...
Scandalous: Christian identification, sex guilt, and the mediated demonization of the participants in the AshleyMadison scandal

In 2015, AshleyMadison.com (AshleyMadison) was hacked, leading to the release of site members' personal information. The exposed members faced public scrutiny, judgment, and other negative outcomes. In this study, we examined predictors of the demonization of the AshleyMadison participants (i.e., AshleyMadison members, owners, hackers) to help explain victim derogation. We attempted to discern the role religiosity and sexual guilt played in the demonization of the AshleyMadison hacking participants. We predicted sexual guilt would mediate between religiosity and demonization of the AshleyMadison hacking participants. Our findings indicate that religiosity alone does not predict demonization. Instead, sex guilt was a necessary part of the equation and mediated between participants' religiosity and the amount they demonized the different groups.
The Argument from Perceptual Relativity

Perhaps the best-known method of introducing sense-data is by means of the Argument from Perceptual Relativity. This argument can be found in the writings of philosophers from antiquity to present times, and there are many different ways of formulating it.1 I shall begin by expounding (only) what seems to me to be the strongest version of the argument; then I shall present the most important contemporary objection to the argument; and finally I shall try to specify the considerations on the basis of which the issue raised by this objection should ultimately be resolved.
Preparing Pharmacists for Collaborative/Integrated Health Settings

Pharmacy practice is changing to accommodate the need for pharmacists to be better team members in newly emerging collaborative care and integrated health systems. Pharmacy schools could lead this change by educating students to be effective participants in these relatively new models of care. Schools are encouraged to follow the approach outlined in the recent guidance published by the Health Professions Accreditors Collaborative (HPAC) for interprofessional practice and education (“the new IPE”). This approach includes articulating an IPE plan, establishing goals, assessing student achievement of the necessary IPE competencies, developing educational plans that are multi-faceted and longitudinal, and modifying the existing assessment/evaluation process to ensure the quality of the IPE effort. These curricular decisions should be based on existing and new research on the effectiveness of IPE on student’s attitudes, knowledge, skills, and behavior. A key decision is how to create effective interactions between pharmacy students and those of other professions. Educational emphasis should be directed toward team building skills, not just individual competencies. The pharmacy faculty probably need to enhance their teaching abilities to accommodate this change, such as learning new technology (e.g., simulations, managing online exchanges) and demonstrating a willingness to teach students from other professions.
Gate-tunable quantum Hall effects in defect-suppressed B i 2 S e 3 films

Despite many years of efforts, attempts to reach the quantum regime of topological surface states (TSS) on an electrically tunable topological insulator (TI) platform have so far failed on binary TI compounds such as $\mathrm{B}{\mathrm{i}}_{2}\mathrm{S}{\mathrm{e}}_{3}$ due to high density of interfacial defects. Here, utilizing an optimal buffer layer on a gatable substrate, we demonstrate the first electrically tunable quantum Hall effects (QHE) on TSS of $\mathrm{B}{\mathrm{i}}_{2}\mathrm{S}{\mathrm{e}}_{3}$. On the $n$ side, well-defined QHE shows up, but it diminishes near the charge neutrality point (CNP) and completely disappears on the $p$ side. Furthermore, around the CNP the system transitions from a metallic to a highly resistive state as the magnetic field is increased, whose temperature dependence indicates presence of an insulating ground state at high magnetic fields.
Challenges for post-Keynesian macroeconomics: a behavioural and structuralist perspective

Post-Keynesian macroeconomics faces several challenges. The labor market and the supply side, first, have not been getting the attention that they deserve in Post-Keynesian growth theory. The failings of the Lucas-type â€˜microeconomic foundationsâ€™, second, must not lead to a neglect of microeconomic behavior. Convincing macroeconomic theories must recognize and address the connections between macroeconomic relations and the microeconomic behavior whose aggregate manifestation the relations represent. Microeconomic behavior, third, takes place within an institutional structure that shapes economic behavior and economic outcomes. Macroeconomic theory must be both behavioral and structuralist.