cssi/SciSciGPT-SciSciNet huggingface dataset:
Who will be participating next?: predicting the participation of Dark Web community

Predicting whether a user will be participating in a thread has broad applications, such as thread recommendation and ranking. In an extremist forum, knowing which user will be interested to join a particular thread with sensitive or threatening information is also important for security agent to prevent or prepare for any potential outbreak of crisis. Traditional methods employed a bipartite graph to represent user-thread relationships and predict potential users for a new coming thread based on user similarities. In this paper, we propose a User Interest and Topic Detection model to extract topics and trends from a document corpus and also discover users' interests toward these trends. Information of user interest is then used to predict potential information consumers for a given thread. Experiments conducted in the Dark Web dataset showed the effectiveness of our approach; especially when we have limited information about who have already participated in an existing new thread.
Acute Pulmonary Embolism

Acute pulmonary embolism may occur rapidly and unpredictably and may be difficult to diagnose. Treatment can reduce mortality, and appropriate primary prophylaxis is usually effective. This review focuses on the pathogenesis, diagnosis, and treatment of acute pulmonary embolism of thrombotic origin.
Pregnancy in Parkinson's disease: case report and discussion.

Parkinson’s disease (PD) is a common neurodegenerative disease, with an incidence of eight to 19 per 100,000 in the USA. Pregnancy in PD is rare, with only 35 pregnancies reported in the medical literature [1–11]. PD is more common in men than women, with ratios between 1.2:1 and 2:1 reported in the literature [12–14]. PD is characterized by the cardinal signs of resting tremor, bradykinesia, rigidity and gait impairment. Therapy for PD is aimed at symptomatic relief, since there are no proven neuroprotective or disease-modifying therapies available. Parkinson’s disease is primarily a disease of older adults, with an average age of onset of 70.5 years [14]; thus, pregnancy in the setting of PD is uncommon. The current literature on pregnancy in PD consists of case reports, which mainly focus on safety, efficacy and tolerability of dopaminergic agents [1–4]. We present a case report of a woman with untreated PD and follow her course before, during and after pregnancy, comparing her disease progression to a PD cohort at a similar stage of the disease. Previous case reports have described pregnancy in women receiving anti parkinsonian medications. The value of this report is the opportunity to observe the symptomatic effects of the stages of pregnancy and the postpartum period in PD, without the superimposed effects of antiparkinsonian therapy. Case report
Reframing the glass ceiling as a socially constructed process : implications for understanding and change

Traditional definitions of the glass ceiling perpetuate gender‐biased organizational practices and quick‐fix solutions. By creating an illusion of opportunity for women, they prevent critical assessment of contemporary organizational practices and of gendered communication. This article engages in feminist research as praxis first by discussing how current organizational practices fail to alter power imbalances. To create awareness of unjust organizing processes, these ways we ordinarily “do gender” are juxtaposed against contrastive contexts: alternative settings (organizational forms), processes (community‐as‐dialectic), and organization members (women). These alternatives enable us to visualize how language creates and sustains gender divisions that emerge in glass ceiling processes and effects. The second stage in research as praxis calls for action. I discuss implications for research and for change that challenge the gendered motif of organizational life.
ARF6 requirement for Rac ruffling suggests a role for membrane trafficking in cortical actin rearrangements

The ARF6 GTPase regulates a novel endosomal-plasma membrane recycling pathway and influences cortical actin remodeling. Here we examined the relationship between ARF6 and Rac1, a Rho family GTPase, implicated in cortical actin rearrangements. Endogenous Rac1 colocalized with ARF6 at the plasma membrane and on the ARF6 recycling endosome in untransfected HeLa and primary human fibroblast cells. In transfected HeLa cells Rac1 and ARF6 also colocalized. Cells expressing wild-type ARF6 or Rac1 formed actin-containing surface protrusions and membrane ruffles, respectively, upon treatment with the G protein activator aluminum fluoride. Aluminum fluoride-treatment of cells transfected with equivalent amounts of plasmid resulted in enhanced membrane ruffling, with protrusions appearing as Rac expression was lowered. Co-expression of the dominant negative, GTP binding-defective ARF6 T27N mutant inhibited the aluminum fluoride-induced ruffling observed in cells expressing Rac1, and the constitutive ruffling observed in cells expressing the activated Rac1 Q61L mutant. In contrast, co-expression of the GTP-binding-defective, T17N mutant of either Rac1 or Cdc42 with ARF6 did not inhibit the aluminum fluoride-induced surface protrusions, nor did inactivation of Rho with C3-transferase. These observations suggest that ARF6, a non-Rho family GTPase, can, by itself, alter cortical actin and can influence the ability of Rac1 to form lamellipodia, in part, by regulating its trafficking to the plasma membrane.
Potential of glucose-lowering drugs to reduce cardiovascular events

Although a clear relationship exists between glycosylated hemoglobin and cardiovascular (CV) disease in individuals with type 2 diabetes mellitus (T2DM) in epidemiologic studies, data from prospective studies are less clear. Earlier prospective studies examining intensive glucose lowering suffered from a lack of statistical power to show CV event reduction, as well as a lack of durable glycemic control and relatively poor control of associated CV risk factors. Although recent CV outcome trials comparing intensive glycemic compared with standard glycemic control have been disappointing, CV event rates appear to be declining substantially in T2DM individuals in the setting of aggressive global CV risk factor modification. No single hypoglycemic agent or combination of agents was associated with increased CV events or mortality. A comprehensive strategy of multifactorial intervention including aggressive and durable glycemic blood pressure, and lipid lowering, aspirin usage, and lifestyle modifications is beneficial in reducing macrovascular and microvascular events in T2DM individuals.
Spatial and temporal observations of summer ice melt using ERS-1 SAR imagery

This study examines the spatial and temporal character of ice melt. Using ERS-1 SAR imagery, the authors examine the development of small floes formed by melt and deformation, and changes in the fraction of open water, small floes and larger floes. They also examine the spatial variations in melt from the marginal ice zone up into the central Arctic ice pack. Results will provide initial estimates of the variation of melt rates and the relative importance of vertical and horizontal melt rates both spatially and temporally.
Experimental treatment of dog lice infestation in interior Alaska wolf packs

Biting dog lice (Trichodectes canis) were first detected on wolves (Canis lupus) in Southcentral Alaska (USA) in 1981 introduced via domestic dogs. Lice infestation expanded north via wolf dispersal to the Tanana Flats of Interior Alaska in December 2003. Effects of this ectoparasite on wolves were persistent with moderate to severe clinical signs of pediculosis lasting multiple generations. Our objectives were to evaluate the extent of lice infestation on wolves within the Tanana Flats and develop a management program that limited further transmission. We implemented a treatment method that consisted of multiple applications of oral antiparasitic ivermectin-injected baits aerially distributed at den and rendezvous sites during mid-May through August. During 2005–2010, we evaluated 12–19 packs annually as part of a treatment group and 3 infested packs as a control. Infestation rates of treatment packs prior to treatment varied from 15% in 2005 (2 of 13), 50% in 2006 (7 of 14), 24% in 2007 (4 of 17), 5% in 2008 (1 of 19), and 0% in 2009–2010 (0 of 19). We treated 50%, 71%, and 75% of the infested treatment packs during 2005–2007, respectively. All treated packs were lice-free the winter following treatment, whereas all 3 control packs remained infested. The combination of treatment and harvest successfully eliminated the local source population of lice within 3 years and we found no evidence of lice infestation within the treatment area during the last 3 years of the study. By using this treatment method, managers can eliminate dog lice infestations of wolves in areas ≤13,000 km2. By initiating treatment promptly after detection, transmission to unexposed nearby packs can be postponed and the local source population of lice on wolves eradicated. © 2013 The Wildlife Society.
Renaissance in Turbulent Boundary Layers, and Impact on Modeling Wall-Bounded Turbulence

The study of high Reynolds number wall-bounded turbulent ows has become a very active area of research in the past decade. Recent advances in experimental and computational results have challenged our understanding, leading to the reassessment of the scaling and asymptotic behavior especially for boundary layer ows. In this study we characterize four di erent localized pressure-gradient con gurations by computing them using four RANS turbulence models (SA, k , SST and RSM), and comparing their predictions with experimental results of the independently measured mean ow quantities and wall shear stress. The pressure gradients were imposed on high Reynolds number, two-dimensional turbulent boundary layers developing on a at plate by changing the ceiling geometry of the 10-meter long test section. Two converging humps (at x = 2:1 and x = 5:5 m from the leading edge of the plate) and two diverging humps at the same locations were considered. Our computations showed that the SST model produced the best agreement with the experiments. The e ect of numerical transition (a procedure by which the code, with the speci c turbulence model, transforms the initial laminar boundary conditions into in ow conditions to characterize the turbulent ow) on the models performance was investigated by solving a zero pressure gradient con guration. We found that this transition process causes the major di erences between the various models, thereby, highlighting the need for models representative of true transition in computational codes. Pressure gradient e ects were studied separately by imposing turbulent pro les from the SST computations as inow conditions for the rest of the models. The SA and k models provided good results under adverse and favorable pressure gradient ow con gurations respectively.
Stocking rate mediates responses of mid-rotation loblolly pine in west-central Arkansas. 2. Profitability

Financial analyses are needed for the wide array of plantation designs commonly used in loblolly pine (Pinus taeda L.) forestry and agroforestry practices. Our objective was to develop an economic model to estimate financial outputs at mid-rotation (14 years old) for 13 loblolly pine stands (plantations) with 546 to 3067 trees ha−1 (TPH). The Excel model allowed costs, returns, growth, and production scenarios to be varied to calculate net present value (NPV) and years to “break even” with and without pine straw. Plantations with ≥2100 TPH and no pine straw harvest had negative NPV and a relatively long break-even period than other plantations at a 5% discount rate. Pine straw harvesting nearly doubled NPV at about 1500 TPH compared to no pine straw, and substantially reduced years to break even at <1500 TPH. There was little difference in NPV between multiple-row plantations. Single-row plantations with ≥1500 TPH should be considered only if pine straw is harvested or a lower discount rate is used. Pine straw harvesting probably would be impractical for the single-row plantations with <1100 TPH, and 2-row and 3-row multiple-row plantations due to low stocking rate and partially open canopies. The model demonstrated the potential financial benefit for harvesting pine straw with timber, especially in the south-central US where pine straw is an underutilized resource.
Tunable electron acceptors based on cyclopenta[hi]aceanthrylenes

A series of substituted cyclopenta[hi]aceanthrylene derivatives with electron donating (NH2, OCH3), neutral (H), and electron withdrawing (COOH, CF3, CN, NO2) substituents were prepared. A room-temperature Sonogashira cross-coupling reaction between 2,7-dibromocyclopenta[hi]aceanthrylene and an appropriately functionalized phenylene ethynylene precursor was utilized to access the materials that were characterized by Nuclear Magnetic Resonance Spectroscopy (NMR), cyclic voltammetry (CV), and UV–Vis spectroscopy. The highest occupied molecular orbital (HOMO) and lowest unoccupied molecular orbital (LUMO) were systematically varied when proceeding from electron donating to electron withdrawing substituents. The optical band gap was significantly altered for the most electron donating species, while little change was observed between different electron withdrawing substituents. This study demonstrates the ability to control the frontier orbital energies of this class of cyclopenta-fused polycyclic aromatic hydrocarbon materials through selective substitution.
Finite element model updating of the UCF grid benchmark using measured frequency response functions

A frequency response function based finite element model updating method is presented and used to perform parameter estimation of the University of Central Florida Grid Benchmark Structure. The proposed method is used to calibrate the initial finite element model using measured frequency response functions from the undamaged, intact structure. Stiffness properties, mass properties, and boundary conditions of the initial model were estimated and updated. Model updating was then performed using measured frequency response functions from the damaged structure to detect physical structural change. Grouping and ungrouping were utilized to determine the exact location and magnitude of the damage. The fixity in rotation of two boundary condition nodes was accurately and successfully estimated. The usefulness of the proposed method for finite element model updating is shown by being able to detect, locate, and quantify change in structural properties.
Diurnal Cycling in Root Resistance to Water Movement

The occurrence of diurnal changes in root resistance of cotton was studied by measuring the flow of water through 35-to70-day-old root systems under a pressure of 3.10 bars or a vacuum of 0.88 bar. The volume of exudate obtained under constant pressure or constant vacuum was 2 to 3 times greater near midday than near midnight indicating that the root resistance apparently was 2 to 3 times greater at night than during the day. The salt concentration of the exudate also cycled; the concentration was lowest at midday and highest at night, hence there was little diurnal variation in the total amount of salt moved per hour. The cycle for volume of exduate, salt concentration, and apparent root resistance had a period of 22 to 26 hours at 24°C. The cycle gradually died away 2 to 3 days after removal of the shoots. The diurnal variations appeared to be controlled by signals from the shoots because the phase of the cycles could be reset by changing the light-dark cycle under which the plants were grown. Cycling was eliminated by exposure to 8 or more days of continuous light before removing the shoots, and cycling could not be entrained by a 6 hour light-6hour dark cycle. Bubbling nitrogen gas through the nutrient medium stopped cycling. A possible role of ion or growth regulator action is discussed.
Condition dependence and the origins of elevated fluctuating asymmetry in quality signals

Developmental stability is the ability of organisms to buffer development against perturbations. Different classes of traits typically have different levels of fluctuating asymmetry (FA), a measure of developmental instability. In particular, elevated FA in sexually selected quality signals has attracted a great deal of attention. There are 3 main hypotheses to explain elevated developmental instability in quality signals. Developmental instability may be related to the cost of trait production, a trait’s condition dependence, or the levels of interindividual trait variation. Here we test these 3 hypotheses by comparing FA in structural traits, nonsignaling color traits, and 2 signaling color traits: a condition-dependent quality signal in Polistes dominulus wasps and noncondition-dependent identity signals in P. fuscatus wasps. Overall, color traits have higher FA than structural traits, though FA differs among the 3 classes of color traits. The clypeal identity signal in P. fuscatus has the highest interindividual trait variation, yet shows relatively low FA, indicating that interindividual trait variation does not explain heightened FA. The quality signal in P. dominulus has the highest FA, though it is not costly to produce. Therefore, the elevated FA in quality signals cannot be attributed to costs of signal production. The quality signal in P. dominulus is condition dependent, however, so our results indicate that increased developmental instability in quality signaling traits can be attributed to their condition-dependent development. A link between developmental stability and condition dependence provides a mechanism through which quality signals may integrate information about overall condition in the absence of costly trait development. Key words: badge of status, condition dependence, fluctuating asymmetry, identity signal, Polistes, quality signal, sexual selection. [Behav Ecol]
A two-step procedure for optimal constrained stabilization of linear continuous-time systems

This paper considers the problem of constrained stabilization of linear continuous-time systems when a quadratic cost criterion is imposed in the design of the state feedback control law. The linear quadratic regulator (LQR) is solved under positivity constraint, which means that the resulting closed-loop systems are not only optimally stable, but also positive. We focus on the class of linear continuous-time positive systems (Metzlerian systems) and use the interesting properties of Metzler matrices to provide the necessary ingredients for the main results of the paper. A two-step procedure is proposed to solve the problem. First, some necessary and sufficient conditions are presented for the existence of controllers satisfying the Metzlerian constraint, and the constrained stabilization is solved using linear programming (LP) or linear matrix inequality (LMI). Second, a sufficient condition is outlined for the existence of a solution to maintain the positivity of the first step while achieving the optimality of LQR. Finally, the robustness of the design is analyzed and possible extension of the design is proposed for an uncertain interval systems. A numerical example is included to illustrate the procedure.
The rising incidence of severe sepsis based on administrative data — real change or coding-driven bias?

Letter Rhee and colleagues conclude in their recent study [1] that a substantial fraction of the administrative databased rise in the incidence of severe sepsis is due to a decreasing threshold of documentation/coding of several types of organ dysfunction (OD). The conclusion was based mostly on diverging rates of rise in code-based OD versus that based on conservative clinical criteria, being faster among the former, coupled with a slower drop in hospital mortality among the latter. However, these findings do not preclude an actual rise in the incidence of severe sepsis as a key driver of the observed trends, with reduced peak severity of sepsisassociated OD over time, possibly related to increasingly timely and effective resuscitative interventions. Indeed, the investigators reported a clinical criteria-based rising incidence of shock (+29 %) versus concomitant drop (−27 %) of acute renal failure. The latter finding may indicate that evolving renal failure has become increasingly less severe than the study’s definition threshold, despite the marked rise in shock. Finally, the slower decrease in hospital mortality among clinical criteria-based OD may alternatively represent a higher likelihood of in-hospital death among patients with more severe OD, while those with relatively less severe OD may be more likely to be discharged to a long-term care facility or hospice, shifting in part their location of death. The later proposition is supported by prior reports [2] and a recent study by Kumar et al. [3] showing that the absolute drop in severe sepsis-associated hospital mortality (12.3 %) was matched by a similar rise (11.6 %) in discharge to a long-term care facility or hospice.
The Origins of Differential Hemispheric Strategies for Information Processing in the Relationships Between Voice and Face Perception

It is proposed that prenatal exposure to maternal speech in concert with different rates of development of the two hemispheres results in a left hemisphere specialization for speech by the time of birth. This specialization together with the tendency for adults to speak to infants as they approach, results in a right hemisphere specialization for faces. It is further proposed that the infants poor resolution of middle and high spatial frequencies constrains the initial right hemisphere processing to one in which configuration of the face rather than specific features are attended to. Improvements in visual functioning lead to a left hemisphere processing of specific features. It is therefore suggested that the characteristic right hemisphere mode of holistic processing and left hemisphere mode of analytic processing derive from early face, voice processing.
Effects of Vegetation, Landscape Composition, and Edge Habitat on Small-Mammal Communities in Northern Massachusetts

In southern New England forests, small mammals provide essential contributions to ecosystem functioning via food-web interactions and seed dispersal. This region has been exposed to extensive habitat fragmentation due to residential and agricultural development, resulting in a considerable amount of edge habitat, in addition to naturally occurring landscape heterogeneity. Limited research has been conducted relating small-mammal species richness and abundance to different types of edge habitat in this region. Studies incorporating an analysis of variation in both fine-scale vegetation and coarse-scale landscape variation are even more limited. We compared small-mammal richness, total abundance, and abundance of Peromyscus maniculatus (Deer Mouse), Peromyscus leucopus (White-footed Mouse), Myodes gapperi (Red-backed Vole), Tamias striatus (Eastern Chipmunk), and Tamiasciurus hudsonicus (Eastern Red Squirrel) at developed-edge, wetland-edge, and forest-interior sites. We also measured vegetation and landscape variables to understand how variation in characteristics at different scales affected small-mammal measures. We selected 4 sites of each edge type and used Sherman live-traps during the summers of 2009–2010 to survey small-mammal populations (75 traps for 4 nights at 12 sites for 2 y = 7200 trap-nights). We did not find differences among edge types and interior forest for total abundance, richness, and abundance of the 5 small-mammal species with sufficient data for analysis. However, vegetation variables and landscape variables were significantly associated with small-mammal populations. Step-wise linear regression included vegetation variables for 4 of the 5 species, and various landscape scales were included in all analyses except abundance of Peromyscus adults. Patch size was included in 4 analyses (positive for total abundance, White-footed Mouse, and Red-backed Vole; negative for Eastern Chipmunk). We found conifer basal area to have a positive relationship with abundance of Peromyscus adults and Red-backed Voles, but a negative relationship with abundance of Peromyscus juveniles and Eastern Red Squirrels. Species abundance and richness of small-mammal communities and populations in northeastern Massachusetts were related to both fine-scale vegetation differences and coarse-scale landscape metrics, but these relationships were complex and scale-dependent.
Platinum coat color locus in the deer mouse

Platinum coat color in the deer mouse, Peromyscus maniculatus, is an autosomal recessive trait marking a locus, pt, distinct from silver (si), albino (c), blonde (bl), brown (b), and agouti (a). Platinum deer mice are conspicuously pale, with light ears and tail stripe. The pewter trait is allelic with and phenotypically identical to platinum, and represents an independent recurrence of this mutant. The rate of recoveries of coat color mutations from wild deer mice is consistent with available data for recurring mutation rates balanced by strong selection against the recessive phenotype.
Lipopolysaccharide upregulates surface expression of CD14 on human alveolar macrophages

This study was undertaken to examine the surface expression and regulation of CD14 on human alveolar macrophages (HAM). HAM obtained by bronchoalveolar lavage were cultured with or without LPS and with or without fetal bovine serum (FBS) on plastic or Teflon surfaces. CD14 expression was assessed by immunofluorescence. The roles of protein tyrosine kinase, protein kinase A, and protein kinase C were also evaluated utilizing inhibitors of these enzymes. HAM expressed very low levels of surface CD14 at baseline. CD14 was upregulated on HAM with time in culture in the presence of FBS and/or LPS; adherence did not affect CD14 expression. Inhibitors of protein kinase C and protein tyrosine kinase prevented the upregulation of CD14 by LPS but did not effect the upregulation of CD14 by FBS. These studies show that LPS can upregulate expression of its receptor on HAM and that this effect is accentuated by serum-derived factors.
Propagation of polarized waves in inhomogeneous media: comment

It is argued in J. Opt. Soc. Am. A.33, 1385 (2016) that some of our previous results on the evolution of the polarization state of electromagnetic beams propagating in atmospheric turbulence are not valid and/or our work is not useful. We address such arguments and give clarifications.
Research Made Useful for Busy Rehabilitation Providers

“Evidence-based practice” (EBP) has become the standard in rehabilitation medicine and psychology in recent decades. EBP is an approach to health care in which clinical decisions are based on (1) the best available research evidence, (2) clinical judgment and expertise, and (3) the values and preferences of the patient. A large literature base supports the idea that the best quality patient care happens when scientific evidence is part of the decision-making process, leading psychology and other health-care professions to support the EBP framework as the standard of care and professional competency. However, despite the wide acceptance of EBP, health-care practitioners and programs often do not follow best available practices. In part, the use of EBP in routine practice is hampered by a perception among some clinicians that the research literature is inaccessible to clinicians, too time consuming to approach, and difficult to understand. In this chapter, we provide readers resources and encouragement for how to effectively find and employ research evidence to inform their use of EBP in the context of rehabilitation medicine.
Hybrid and adaptive drone identification through motion actuation and vision feature matching: poster abstract

Unmanned aerial vehicle (UAV) swarms provide situation awareness in tasks such as emergency response, search and rescue, etc. However, most of these scenarios take place in GPS-denied environments, where accurately localizing each UAV is challenging. Heterogeneous UAV swarms, in which only a subset of the drones carry cameras, face the additional challenge of identifying each individual UAV to avoid sending position updates to the wrong drone, thus crashing. This work presents an identification mechanism based on the correlation between motion observed from external camera, and acceleration measured on each UAV's accelerometer.
Abstract 098: Blocking Cardiac Gq-Receptor Coupling Prevents Adverse Remodeling and Preserves Myocardial Function after Ischemic Injury in Mice and Promotes Repair via Cardiac Regeneration

Background: Studies have shown that the heterotrimeric G protein, Gq, is a critical molecule in the development of myocardial hypertrophy and heart failure (HF). In the present study, we examined whether Gq signaling is also a critical pathological trigger for adverse remodeling and HF after ischemic injury. Using cardiac-specific transgenic mice with expression of a specific Gq inhibitory peptide (GqI) that blocks Gq-GPCR coupling allowed us to investigate whether Gq inhibition can alter cardiac structure and functional changes after myocardial infarction (MI). Methods and Results: Cardiac-specific GqI transgenic (TG) and non-transgenic littermate control (NLC) mice were subjected to MI. Serial echocardiography performed before ischemia as well as 2, 4, 8 weeks after MI injury show that TG mice develop less progressive LV enlargement and dysfunction. The % LV EF and FS were significantly improved in the TG compared to NLC mice at 8 weeks post-MI. Consistently, cardiac contractility (+dP/dt) and relaxation (-dP/dt) were significantly improved in TG mice also when stimulated with isoproterenol. The LVEDP, the heart weight to body weight (BW) and lung to BW ratios were significantly less in TG mice, indicating that HF was limited with GqI expression. Moreover, TG mice have smaller infarcts, less LV dimensions and lower fibrosis in both the border zone and remote area with clearly more viable tissue in the scar region. Constantly, there are more micro-vessel and more BrdU(+) cardiomyocytes in the scar area and border zone at the 2 week post-MI in TG group. Western blot shows a consistent decrease in phosphorylated PKC substrates and higher levels of activated Akt in TG mice. Over expression of the GqI in cultured H9c2 myoblasts did lead to higher level of Ki67 positive cells (38.06±2.46%) than a control group (21.78±2.64%) and FACS analysis showed that Gq inhibition increased the % of H9c2 cells in S phase and G2/M phase compared to control cells. Conclusion: These data indicate cardiac specific Gq inhibition protects the heart against adverse LV remodeling and HF progression after MI. Mechanisms attributed to GqI expression appear to include improved myocyte survival, less fibrosis, and promotion of angiogenesis and cardiac repair through regeneration.
The parabasalid symbiont community of Heterotermes aureus: Molecular and morphological characterization of four new species and reestablishment of the genus Cononympha

The subterranean termite Heterotermes aureus is endemic to arid regions of southwestern USA and northern Mexico. Like other termites in the family Rhinotermitidae, it harbors a community of protists (Phylum Parabasalia) in its hindgut that aid in cellulose digestion. We investigated the hindgut community of H. aureus using light microscopy, single cell isolation, and high throughput amplicon sequencing. Here we describe four new parabasalid species from the classes Trichonymphea and Spirotrichonymphea. Three of the new species include Pseudotrichonympha aurea (Trichonymphea), Holomastigotoides aureus, and Holomastigotoides oxyrhynchus (Spirotrichonymphea). The fourth new species is a Spirotrichonympha-like protist for which we reinstate the genus Cononympha and describe under the name Cononympha aurea (Spirotrichonymphea). We also used high throughput amplicon sequencing with custom primers on DNA from fresh and ethanol preserved termites collected across the southwest USA and Mexico to investigate population-level differences in hindgut community composition. We report that the community is highly similar across populations: no additional parabasalid species were identified in any of the H. aureus specimens, but several specimens appeared to lack either C. aurea or H. oxyrhynchus.
Pollution in Everglades

The Everglade is common called “The river of grass” is most important river for Florida, The Everglades cover about 1,500,000 acres where habit wonderful species of animals and plants, the Everglades also supply fresh water for almost all Florida and it’s a land suitable for farming, the benefits that we receives of this area are a lot, but unfortunately the humans has contaminated this sources of water for many years. The pollution consequences affect all type of being livening in Florida, animals, plants include population Floridian. The Everglades is not only a principal source of water but also is a perfect land for agriculture, since the war world end the farmers began growing vegetable and sugar cane. The Everglades is a home for many species of animals animal and plants that make a wonderful place, but the pollution other factor produced by man to cause problem in this beautiful place.
Metformin Use in Children and Adolescents with Prediabetes

With the increasing incidence of childhood obesity, clinicians need to understand its comorbidities and their management. The American Diabetes Association recommends pediatricians screen high-risk overweight and obese children. Identifying and treating prediabetic children and adolescents can help to reduce the burden of type 2 diabetes. Lifestyle interventions are pivotal. Metformin is the only oral medication approved for diabetes treatment in children. It has been studied in clinical trials in nondiabetic children and has been shown to have beneficial effects on body weight. Effects on diabetes prevention have not been studied and long-term data are limited in the pediatric population.
Anomalous electrical response in ethanol-adsorbed zinc oxide thin films under visible light

In this paper we report a unique electrical response of ethanol-adsorbed ZnO films subjected to a constant potential difference. Current measurements were obtained in both dark and illuminated conditions. A significant delay in achieving saturation current was observed indicating a nonlinear and time varying effective resistance; a time-dependent equation describing this behavior was developed, allowing the calculation of a time constant for the transition regime. To determine the role of the surface properties in this behavior, microwave plasma was used to etch the ZnO film by varying degrees, resulting in an enhancement of the resistance switching for extended etching times.
Restoration of Coastal Foredunes, a Geomorphological Perspective: Examples from New York and from New Jersey, USA

The basic geomorphological model of processes acting upon sediment to produce a morphological response is the foundation for restoration of the coastal foredune. Conceptionally, the provision of sediment to the site of foredune development is at the core of foredune restoration. Other approaches to foredune development incorporate rehabilitation of the feature or construction of a sand ridge in non-equilibrium locations. A geomorphological model of foredune restoration/manipulation is presented to provide contextual perspective to the range of natural processes and cultural modifications.
Brain metastases from fallopian tube carcinoma responsive to intra-arterial carboplatin and intravenous etoposide: a case report.

Fallopian tube carcinoma is the least common neoplasm of the female genital tract. Although rare, neurological complications such as brain metastases can develop. It remains unclear, however, what role chemotherapy has in the treatment of these patients and what route of administration is most effective. Intra-arterial (IA) regional administration of chemotherapy may increase intra-tumoral drug concentrations and improve efficacy. We report the case of a 47-year-old woman who developed bilateral fallopian tube cancer and multifocal brain metastases. After progression through radiation therapy and oral chemotherapy, she was placed on IA carboplatin (200 mg/m2/d×2 days every 4 weeks) and intravenous etoposide (100 mg/m2/d×2 days every 4 weeks). During treatment she had objective tumor shrinkage that has remained stable for more than 12 months. For patients with fallopian tube carcinoma that develop brain metastases and respond poorly to surgery and/or irradiation, multi-agent chemotherapy containing carboplatin should be considered. The effectiveness of carboplatin may be improved if administered by the IA route.
Diabetes Care in 2019-Who, Why, What, and How?

Once again it’s time for the editor’s annual message to the readers of Diabetes Care . Early last year we celebrated the 40th anniversary of the journal (1), and in midyear we discussed some of the big topics addressed by articles in 2018 (2). Shortly after that report, we were delighted to learn that the impact factor for Diabetes Care had risen from 11.9 in 2017 to 13.4 in 2018. For 2019, I want to offer a look inside the journal, a description of why and how the hardworking group behind the journal puts together its monthly issues. First, I want to thank everyone involved for their efforts to make the journal an important resource for the diabetes community. Next, just a few statistics. During 2018, we received approximately 2,700 initial submissions and 550 revised manuscripts with an overall acceptance rate of just below 13%. The acceptance rate for Original Articles continues to be near 10%. You may find it surprising that, over the course of the last two decades, >70% of yearly submissions have come from outside the U.S. The numbers of submissions are quite stable, but we believe their quality continues to rise. It takes a lot of people to produce Diabetes Care . Contributors include authors, the editor in chief and 3 ad hoc editors in chief, 16 associate editors, 38 members of the editorial board, countless reviewers, the editorial staff, copyeditors, and production staff. Our families and friends sometimes ask why we spend so many hours at the keyboard. Why not work at other professional tasks, or take more time off? What most fail to realize is that the journal’s clock never stops. New and revised manuscripts, reviews, and communications about them never cease coming in, including evenings, weekends, and holidays. Sometimes hard decisions …
Exploring Racial and Ethnic Differences in Recovery Maintenance From Mobility Limitation.

Objective: This research examines whether racial and ethnic minorities experience less recovery maintenance (i.e., maintaining their recovery status 2 years later). Method: Using Waves 4-12 (1998-2...
Supporting early social and emotional relationships through a public health parenting program: The legacy for children™ intervention

This chapter describes a group-based public health approach to prevent developmental delays associated with poverty by supporting positive parenting. Legacy for Children™ (Legacy) is designed to support sensitive, responsive mother–child relationships, build maternal self-efficacy, and foster peer networks of support among mothers living in poverty. Legacy groups start during pregnancy or infancy, and mothers in the group all have children within several months of the same age. Mothers can attend the group until their children are age 3 or 5 years, depending on the curriculum version. As the children age, the curriculum covers developmentally appropriate topics such as attachment, discipline, maternal self-care and stress reduction, reading and literacy, safety and nutrition, and promotion of child social skills. Randomized controlled trial (RCT) data from Legacy indicate intervention effects 3–6 years post-intervention for child socioemotional and cognitive outcomes. Legacy is currently being implemented in sites across the United States in a variety of infrastructures: child care, health care, and community-based organizations. Implementation has been supported by the Centers for Disease Control and Prevention (CDC) through training and technical assistance. Legacy has been adapted and translated for Spanish speakers; implementation and evaluation of Legacy for Spanish-speaking mothers is underway. Implementation, scalability, and next steps for the program are discussed as well as the importance of a developmental focus in programming.
High-fidelity, high-isotropic-resolution diffusion imaging through gSlider acquisition with B 1 + and T 1 corrections and integrated ΔB 0 /Rx shim array.

Purpose B 1 + and T1 corrections and dynamic multicoil shimming approaches were proposed to improve the fidelity of high-isotropic-resolution generalized slice-dithered enhanced resolution (gSlider) diffusion imaging. Methods An extended reconstruction incorporating B 1 + inhomogeneity and T1 recovery information was developed to mitigate slab-boundary artifacts in short-repetition time (TR) gSlider acquisitions. Slab-by-slab dynamic B0 shimming using a multicoil integrated ΔB0 /Rx shim array and high in-plane acceleration (Rinplane = 4) achieved with virtual-coil GRAPPA were also incorporated into a 1-mm isotropic resolution gSlider acquisition/reconstruction framework to achieve a significant reduction in geometric distortion compared to single-shot echo planar imaging (EPI). Results The slab-boundary artifacts were alleviated by the proposed B 1 + and T1 corrections compared to the standard gSlider reconstruction pipeline for short-TR acquisitions. Dynamic shimming provided >50% reduction in geometric distortion compared to conventional global second-order shimming. One-millimeter isotropic resolution diffusion data show that the typically problematic temporal and frontal lobes of the brain can be imaged with high geometric fidelity using dynamic shimming. Conclusions The proposed B 1 + and T1 corrections and local-field control substantially improved the fidelity of high-isotropic-resolution diffusion imaging, with reduced slab-boundary artifacts and geometric distortion compared to conventional gSlider acquisition and reconstruction. This enabled high-fidelity whole-brain 1-mm isotropic diffusion imaging with 64 diffusion directions in 20 min using a 3T clinical scanner.
Understanding Conformational Preferences of Atropisomeric Hydrazides and Its Influence on Excited State Transformations in Crystalline Media

Hydrazides derivatives were evaluated to understand the role of N-N bond in dictating the outcome of photoreactions in the solid state.
Left Interhemispheric Craniotomy for Resection of Cavernous Malformation: 2-Dimensional Operative Video

Thalamic cavernous malformations pose variable surgical challenges given that the location and size of the lesion often determine the approach surgical trajectory. The patient in this case has a large thalamic cavernous malformation that results in a mass effect on the third ventricle and directly abuts the lateral ventricle. A small interhemispheric craniotomy is performed to allow for an anterior interhemispheric transcallosal approach to the lesion. The lateral ventricle is accessed, and the septum is removed to enhance visualization of the surgical field. A small rim of normal parenchyma on the lateral margin of the thalamus is transgressed, and the cavernous malformation is entered. The lesion is removed in a piecemeal manner. Use of counter traction assists with the piecemeal removal. The lighted suction is critical during inspection and manipulation of the lesion within the resection cavity given the limited lighting deep within the cavity. The lesion was removed completely, and postoperative imaging confirms gross total resection. The patient gave informed consent for surgery and video recording. The institutional review board approval was deemed unnecessary. Used with permission from the Barrow Neurological Institute.
Metadata Use in OAI-Compliant Institutional Repositories

This preliminary study examines the use of Dublin Core (DC) metadata in Institutional Repositories (IRs) that participate in the Open Archives Initiative (OAI). The study concerns evaluating IRs with respect to the quality of their indexing. In particular, I argue that in order to support successful retrieval of information, IR developers should endeavor to populate their indexes with well-structured metadata. The current study provides an initial motivation for this argument by analyzing the degree to which presently available IR metadata evidences such structure.
Architecture of the Short External Rotator Muscles of the Hip

Muscle architecture, or the arrangement of sarcomeres and fibers within muscles, defines functional capacity. There are limited data that provide an understanding of hip short external rotator muscle architecture. The purpose of this study was thus to characterize the architecture of these small hip muscles. Eight muscles from 10 independent human cadaver hips were used in this study (n = 80 muscles). Architectural measurements were made on pectineus, piriformis, gemelli, obturators, quadratus femoris, and gluteus minimus. Muscle mass, fiber length, sarcomere length, and pennation angle were used to calculate the normalized muscle fiber length, which defines excursion, and physiological cross-sectional area (PCSA), which defines force-producing capacity. Gluteus minimus had the largest PCSA (8.29 cm2) followed by obturator externus (4.54 cm2), whereas superior gemellus had the smallest PCSA (0.68 cm2). Fiber lengths clustered into long (pectineus - 10.38 cm and gluteus minimus - 10.30 cm), moderate (obturator internus - 8.77 cm and externus - 8.04 cm), or short (inferior gemellus - 5.64 and superior gemellus - 4.85). There were no significant differences among muscles in pennation angle which were all nearly zero. When the gemelli and obturators were considered as a single functional unit, their collective PCSA (10.00 cm2) exceeded that of gluteus minimus as a substantial force-producing group. The key findings are that these muscles have relatively small individual PCSAs, short fiber lengths, and low pennation angles. The large collective PCSA and short fiber lengths of the gemelli and obturators suggest that they primarily play a stabilizing role rather than a joint rotating role.