cssi/SciSciGPT-SciSciNet huggingface dataset:
Regulation of SRC kinases by microRNA-3607 located in a frequently deleted locus in prostate cancer

Genomic studies suggest that deletions at chromosome (chr) 5q region (particularly chr5q14-q23) are frequent in prostate cancer, implicating this region in prostate carcinogenesis. However, the genes within this region are largely unknown. Here we report for the first time, the widespread attenuation of miR-3607 - a microRNA gene located at chr5q14 region- in prostate cancer. Expression analyses of miR-3607 in a clinical cohort of prostate cancer (PCa) specimens showed that miR-3607 is significantly attenuated and low miR-3607 expression is correlated with tumor progression and poor survival outcome in prostate cancer. Our analyses suggest that miR-3607 expression may be a clinically significant parameter with an associated diagnostic potential. We examined the functional significance of miR-3607 in prostate cancer cell lines and found that miR-3607 overexpression led to significantly decreased proliferation, apoptosis induction and decreased invasiveness. Further, our results suggest that miR-3607 directly represses oncogenic SRC family kinases, LYN and SRC, in prostate cancer. In view of our results, we propose that miR-3607 plays a tumor suppressive role in prostate cancer by regulating SRC kinases that in turn regulates prostate carcinogenesis. To our knowledge this is the first report that: (i) identifies a novel role for miR-3607 located in a frequently deleted region of prostate cancer and (ii) defines novel miRNA mediated regulation of SRC kinases in prostate cancer. Since SRC kinases play a central role in prostate cancer progression and metastasis and are attractive targets, this study has potential implications in the design of better therapeutic modalities for prostate cancer management.
Optimizing Plasma Synthesis for ‘Dirty’ ${\rm MgB}_{2}$

During the past two years remarkable improvements in the superconducting MgB2 properties of have been achieved by alloying C or SiC in the MgB2 lattice. A new approach to the synthesis of dasiadirtypsila MgB2 is being developed using an rf plasma torch. The laminar flow of reactants in the plasma makes possible a new method to access non-equilibrium alloying of additives into the crystal structure of a powder. Design concepts and initial results will be presented.
Control of torsionally asymmetric structures

The effects of near-field earthquakes with large velocity pulses has motivated passive damping requirements for the protection of seismically isolated structures. Structures in which the first mode damping exceeds twenty or thirty percent typically do not exhibit classical modes and simulation via the superposition of uncoupled second order equations is not possible. When the damping effects are created by non-linear mechanisms such as yielding or friction, the behavior of the structure is amplitude dependent and an analysis is commonly carried out in the time domain. In this paper, earthquake time history analyses are applied to study the influence of isolation damping on higher-mode effects and inter-story drift ratios. A simple comparison of isolation damping mechanisms cannot be carried out via simple 1-DOF or 2-DOF realizations. So, in order to incorporate realistic details in the study of the dynamic behavior of these structures, and also to provide general conclusions, a set of L-shape planned, 8-story building models with different isolation periods, isolation damping characteristics, and levels of isolation stiffnesses are studied.
The Sacks density theorem and Σ 2 -bounding

The Sacks Density Theorem [7] states that the Turing degrees of the recursively enumerable sets are dense. We show that the Density Theorem holds in every model of P− + BΣ2. The proof has two components: a lemma that in any model of P− + BΣ2, if B is recursively enumerable and incomplete then IΣ1 holds relative to B and an adaptation of Shore's [9] blocking technique in α-recursion theory to models of arithmetic.
Development of an automatic laboratory-scale respirometric system to measure polymer biodegradability

Abstract An automatic direct measurement respirometric system was built, calibrated and tested to determine polymer biodegradation under simulated environmental conditions. The amount of carbon dioxide produced during biopolymer biodegradation was converted to percentage of mineralization, and used as an indicator of the polymer biodegradation. Poly(lactide) (PLA) bottles were used as the test material, and the results were compared with those from corn starch powder and poly(ethylene terephthalate) (PET) bottles. The respirometric system ran for more than 63 days without any user intervention, very stable and efficiently. At 63 days of exposure at 58±2 °C and 55±5% relative humidity, PLA, corn starch, and PET achieved 64.2±0.5%, 72.4±0.7%, and 2.7±0.2% mineralization, respectively. Based on ASTM D 6400 and ISO14855, PLA bottles qualify as biodegradable since mineralization was greater than 60%.
Electronic Communication and Changing Organizational Forms

We introduce this Special Issue by providing an overview of the interplay between communication technology and various dimensions of new organizational forms. We consider the major factors motivating dramatic change within and between organizations today, and describe key dimensions of intraorganizational and interorganizational forms that are linked to electronic communication technologies: vertical control, horizontal coordination, size of organization and constituent units, new types of coupling, core product, communication cultures, ownership and control, interorganizational coupling, strategic alliances, and interstitial linking. Our purpose is to sample the changes attendant upon advances in electronic communication and organizational forms, with the goal of energizing future research. Our overview uncovers possibilities for new avenues of study within the technology-organization relationship and reveals the important contributions made by the articles in this Special Issue.
From consensus to conflict: the domestic political economy of East-West energy trade policy

Changes in the domestic politics of East-West energy trade policy indicate a more general transformation of the domestic politics of American foreign policy. In the postwar period the basic, consensual pattern of congressional bipartisanship, executivebranch unity, interest-group collaboration, and a supportive public has been replaced by the conflictual pattern of an assertive Congress, a fragmented executive branch, antagonistic interest groups, and a divided public. These contrasting patterns are manifestations of structural changes in the domestic political economy. Along both political and economic dimensions, and differentiated according to whether the locus of pressure was group-specific or more general, what had been basic foundations of consensus became by the early 1970s fissures of conflict. Of particular significance were the weakening of the macropolitical foundations (the basic accord on foreignpolicy objectives and strategies) in the wake of both Vietnam and detente and the increased marginal value of the economic costs, both diffuse (macroeconomic) and particularistic (microeconomic), to be paid for economic coercion. In this transformed context, the state's support-building instruments of ideology and economic compensation were insufficient to build consensus. As a result, in this issue area and perhaps more generally, high levels of domestic constraints on the conduct of American foreign policy have become the rule rather than the exception.
A Practical Approach to Headache Treatment

The World Health Organization cites migraine headache as one of the 20 most disabling medical conditions. This article focuses on the diagnosis and treatment of the primary headache disorders, with...
POPULATION SIZE AND RECOVERY CRITERIA OF THE THREATENED LAKE ERIE WATERSNAKE: INTEGRATING MULTIPLE METHODS OF POPULATION ESTIMATION

ABSTRACT The Lake Erie watersnake, Nerodia sipedon insularum, occurs only in the island region of western Lake Erie, an area less than 40 km in diameter. Restricted geographic distribution and declining population size resulted in this snake's classification as Threatened in the U.S. and Endangered in Ontario and Ohio. A combination of mark-recapture methods, capture rate information, and interpolation were used to estimate the current U.S. population size of Lake Erie watersnakes. A total of 121 point estimates were generated using both ‘closed’ population (Lincoln–Petersen, Schumacher's) and ‘open’ population (Jolly–Seber, Bailey's triple-catch) methods to analyze data collected from 1980–2004. Paired t-tests, comparing estimates obtained using alternative methods, were consistently non-significant. Although standard errors and confidence intervals of individual estimates were often large, standard errors of mean estimates, obtained by averaging across methods and sets of consecutive years, were markedl...
Harnessing information technologies to improve the delivery of diabetes care to veterans: the future is today.

Background: Although momentum is now building nationally for improved informatics, progress has been incremental in most cases. One notable exception is the Veterans Health Administration, which utilizes one of the most widely used electronic medical record systems in the world. Objectives: The articles in this symposium demonstrate the implementation of technology to move beyond the electronic medical record at the time of the medical encounter to improve timeliness and outcomes of care delivery for veterans with diabetes. Results: We report on the use of electronic registries and nurse practitioner-based programs across multiple sites to improve glycemic control; the implementation of a digital retinal imaging system in primary care clinics; the use of health information technology to improve patient self-care; and the development of a research database to move beyond performance measurement to evaluate longitudinal outcomes. Conclusions: While these articles demonstrate the ability of a single national system of care to harness the power of technology to novel strategies for the delivery of care and its evaluation, the technology is scalable from small group practices to regional health care systems.
Building Knowledge: A Framework for a Translational Research Culture in Architecture

The built environment in the United States is failing. Economic, social, environmental and technological performance of buildings as well as the industry responsible for their creation has not kept pace with other industries essential to a ensuring a healthy society. While research activity is prevalent in academia as well as, to some extent, in professional practice, the building industry is slow to change. This paper proposes a framework for the development of a translational research culture in the discipline of architecture as a means to more rapidly implement positive change within the building industry. Modeled after the successful approach implemented in the medical profession, translational research results in a feedback loop where basic research is tested in application. The results of this application become inputs to a new round of basic research, which will then be tested again. This cycle continues with the new research questions continuously being influenced by the limitations of the previous questions. Its application inmedicine was originally intended to ensure that new treatments and research knowledge actually reach thepatients or populations for whom they are intended and are implemented correctly. Establishing atranslational research culture within the discipline of architecture provides a potential stop gap to slow andreverse the declining state of the building industry. By more directly connecting the efforts of research in academia with the application in practice, there exists the potential to make research more visible
A case study of the teacher education faculty’s perception of the eFolio program at a private Central Texas university.

The qualitative case study approach investigated the perceptions that Teacher Education Faculty (TEF) developed as a result of using the electronic portfolio, or eFolio, in the teacher education program at the institution that was studied. The research questions were: (1) What are the perceptions of TEF of the success of the eFolio program at the institution? (2) What are the perceptions of TEF of the technical support provided for the eFolio at the institution? (3) What are the perceptions of the TEF of using the eFolio as an assessment of the teacher education program to meet accreditation standards? (4) What are the perceptions of the TEF of using the eFolio to meet technology integration in teacher education requirements? (5) What are the perceptions of the TEF of using the eFolio for teacher candidate assessment? The mixed method study used both qualitative and quantitative data analysis procedures. The study used three sources of data: email correspondence records between Teacher Education Faculty (TEF) and eFolio Support, an online survey, and follow-up semi-structured face-to-face interviews. Results (1), of analysis of data revealed that 85% of TEF members perceived the eFolio to be worth the time. (2), evidence indicated 75% of the TEF perceived the technical support candidates received for the eFolio to be beneficial. (3), analysis of data show that 60% of TEF perceived the eFolio’s as a tool to be used in accreditation. (4), 65% of TEF in the study reported they did not perceive the eFolio as a way to integrate technology in the teacher education curriculum. (5), result of data analysis revealed that 65% of TEF reported the eFolio was a successful way to assess candidates. The study contributed to the emerging body of research concerning the use of the eFolio in teacher education programs. As the use technology continues to grow in teacher preparation programs, the eFolio will take the place of the traditional hard copy portfolio for candidate assessment, technology integration, and program accreditation.
Effect of carnitine on uptake, oxidation and esterification of palmitate by the perfused rat heart.

SummaryThe effect of carnitine on the uptake, oxidation, and esterification of circulating palmitate has been studied with the isolated perfused rat heart. At concentrations of 0.5 mM and 5.0 mM, carnitine depressed the extraction of palmitate by perfused heart throughout the 45-min perfusion period. There was no significant effect of perfusing carnitine on the oxidation of labeled palmitate to 14CO2, but this could be explained by the low level of carnitine uptake under the same experimental conditions. Despite this, both levels of carnitine resulted in an increased percentage of recovery of extracted palmitate in the esterified lipids of the heart. Among the various lipid fractions of cardiac tissue, 5 mM carnitine perfusion caused a decrease in the percentage of label in unesterified fatty acids and diglycerides, and a significant increase in label recovered as phospholipids and triglycerides. This apparent increase in esterification of labeled palmitate was confirmed by separation of the subcellular f...
Quantifying export flows of used electronics: advanced methods to resolve used goods within trade data.

There is limited convincing quantitative data on the export of used electronics from the United States (U.S.). Thus, we advance a methodology to quantify the export flows of whole units of used electronics from the U.S. using detailed export trade data, and demonstrate the methodology using laptops. Since used electronics are not explicitly identified in export trade data, we hypothesize that exports with a low unit value below a used–new threshold specific to a destination world region are used. The importance of using the most disaggregated trade data set available when resolving used and new goods is illustrated. Two detailed U.S. export trade data sets were combined to arrive at quantities and unit values for each port, mode of transport, month, trade partner country, and trade code. We add rigor to the determination of the used–new threshold by utilizing both the Neighborhood valley-emphasis method (NVEM) and published sales prices. This analysis found that 748 to 1199 thousand units of used laptops ...
FAUNAL TURNOVER AND DEVELOPMENT OF FOSSIL AVIFAUNAS IN SOUTH AMERICA.

Quantitative studies of faunal dynamics based on estimates of rates of origination and of extinction are now commonplace for American fossil mammals (Webb, 1969, 1976; Raup and Marshall, 1980; Marshall, 1981; Marshall et al., 1982b), but do not exist for fossil birds. Selander (1965) described the transition from Pleistocene to Holocene in North American birds, and Brodkorb (1960, 197 1 b), Fisher (1967), Simpson (1980b), and Storer (1960, 1971 b) presented some data on turnover for fossil birds in general. All these avian studies are largely qualitative, however. Of course the rich mammalian fossil record lends itself more easily to a quantitative analysis than does the poorer avian one. But the avian record is not so scanty as is often believed by ornithologists working on Recent avifaunas, or by paleontologists used to the rich record of other groups of organisms. In the last two decades many new avian fossil taxa have been described, and many fossils described earlier have been re-examined critically (Feduccia, 1981). In this report I discuss the fossil South American faunas, reserving a comparative analysis of North and South American avifaunas for another paper. My study, based on a survey of all the fossil birds described from South America up to 1981 inclusive, is to the best of my knowledge the first attempt to estimate parameters of faunal dynamics in any Cenozoic avifauna. I address two specific questions: (1) Can fossil avifaunas be safely reconstructed on the basis of distributional data on Holocene faunas? Authors like Mayr (1964) have tried to reconstruct Cenozoic American bird faunas from Recent ones, whereas others, like Howell (1969), have restricted their reconstructions to the time since the Pliocene. (2) Can data on fossil birds be used to estimate the rates of origination of new taxa (based on first appearance in the fossil record), of extinction (last appearance in the fossil record), and hence of faunal turnover? Such estimates are important in fine-grained analyses of mammalian faunal successions, especially during the time of the Great Interchange (Marshall, 1981; Marshall et al., 1982b), and it would be valuable to have comparable information for the Class Aves.
Allergic bronchopulmonary aspergillosis caused by Aspergillus ochraceus.

A case with the characteristics of allergic bronchopulmonary aspergillosis is described. The species of Aspergillus involved, A. ochraceus , has not previously been found in this disorder. The organism had antigenic properties distinct from five other species of Aspergillus most commonly associated with allergic bronchopulmonary aspergillosis. The patient had immediate skin test, immunodiffusion, and radioallergosorbent reactivity to the species. Four per cent of 112 serum samples from others suspected of having allergic bronchopulmonary aspergillosis had precipitins to A. ochraceus only. It may be necessary in some cases to prepare and test extracts of the patient’s Aspergillus isolate in order to confirm the diagnosis.
Computers and Data Processing for Nervous System Research

Some important requirements are outlined for future research on the nervous system if more complex details are to be determined and effectively applied to engineering systems. In particular, these include the development of more precisely controlled and accurate complex stimulus-response experiments, the rapid analysis of characteristically noisy records for the detection of fine detail responses and the intensive correlation of such experiments with adequate theoretical modeling. An "on-line" remote computer station used in conjunction with a central data processing system is described which facilitates the above objectives. This biological control and data processing system is designed to control and accurately record complex multistimuli multiresponse experiments, rapidly digitize pertinent information, send this to the central computer and also receive back analyzed results in graphical form. The application of the system to specific research, at the California Institute of Technology, on sight perception systems is illustrated. Particularly pertinent has been its use to accurately determine and analyze the complex flight torque phototropisms of the housefly, Musca domestica. Less sophisticated experiments made before the application of this data processing system were most discouraging. This was due to the extreme variations between single records, the large apparent noise or uncorrelated responses together with the evidence of complex multifrequency responses and variable sensitivity to different components of the stimuli. The application of the computer system resolved the data analysis problems and many of the required stimulus accuracy problems.
Optimized design of logistics management information system

In this paper, a resolution to constructing information system is proposed by using object-oriented method, which enclose similar functions and reduce duplicating of codes. The example shows that the method make the system less complicated, more reusing and better properties.
Evaluation of Pedal Lymphangiography in Staging Non-Seminomatous Testicular Carcinoma

AbstractAn analysis is presented on 45 patients undergoing pedal lymphangiography followed by retroperitoneal lymphadenectomy for non-seminomatous testicular carcinoma. Retroperitoneal node metastases were predicted correctly with the lymphangiogram in 10 of 20 patients (50 per cent). The over-all predictive accuracy was 62 per cent.
Subsequent Tumor Analysis of 36 Patients Who Have Received Intravesical Mitomycin C for Superficial Bladder Cancer

AbstractWe studied 36 patients with stages O and A (Tis, Ta and T1) bladder cancer who had received 8 weekly doses of 30 or 40mg. mitomycin C as definitive therapy. Of this group 16 had failed thiotepa therapy and 13 had grade III tumors (6 multifocal carcinoma in situ). The complete response rate at 12 weeks was 45 per cent (negative biopsy and cytology), while an additional 33 per cent had a partial response. Response did not correlate with tumor grade or stage. Patients who had failed thiotepa therapy were less likely to have a complete response, although the over-all response rate was identical to patients who had either not received prior chemotherapy or were not clear thiotepa failures. Followup of these patients indicates that the complete responders were benefited by this regimen since the subsequent recurrence rate was reduced when compared prior to initiation of mitomycin C. Most of these patients received monthly maintenance therapy.
Two New Species ofPterydriasReitter (Coleoptera: Ripiphoridae), Significantly Expanding the Biogeographic Range of the Genus

Abstract Two new species are described in the rare, enigmatic wedge-beetle genus Pterydrias Reitter (Ripidiinae: Eorhipidiini): Pterydrias cattieni Falin and Engel, new species, from Cat Tien National Park, southern Vietnam; and P. pondolandensis Falin and Engel, new species, from Pondoland, Eastern Cape Province, South Africa. The new species are distinguished from their congeners, and a revised key to the species is presented. Comments are made concerning the diversity and biogeography of Pterydrias and other ripidiines and previous hypotheses as to eorhipidiine hosts, and some notable abdominal structures are highlighted.
Measurement of Subpicosecond Electrical Pulses Using Optical Second-Harmonic Generation

We report the application of an optical second-harmonic sampling technique that allows for the detection of subpicosecond electrical transients.
Demonstrate Scale-up Procedure for Glass Composite Material (GCM) for Incorporation of Iodine Loaded AgZ.

Two large size Glass Composite Material (GCM) waste forms containing AgI-MOR were fabricated. One contained methyl iodide-loaded AgI-MOR that was received from Idaho National Laboratory (INL, Test 5, Beds 1 – 3) and the other contained iodine vapor loaded AgIMOR that was received from Oak Ridge National Laboratory (ORNL, SHB 2/9/15 ). The composition for each GCM was 20 wt% AgI-MOR and 80 wt% Ferro EG2922 low sintering temperature glass along with enough added silver flake to prevent any I2 loss during the firing process. The silver flake amounts were 1.2 wt% for the GCM with the INL AgI-MOR and 3 wt% for the GCM contained the ORNL AgI-MOR. The GCMs, nominally 100 g, were first uniaxially pressed to 6.35 cm (2.5 inch) diameter disks then cold isostatically pressed, before firing in air to 550°C for 1hr. They were cooled slowly (1°C/min) from the firing temperature to avoid any cracking due to temperature gradients. The final GCMs were ~5 cm in diameter (~2 inches) and non-porous with densities of ~4.2 g/cm³. X-ray diffraction indicated that they consisted of the amorphous glass phase with small amounts of mordenite and AgI. Furthermore, the presence of the AgI was confirmed by X-ray fluorescence. more » Methodology for the scaled up production of GCMs to 6 inch diameter or larger is also presented. « less
Resource management in cyber-physical systems

Cyber physical systems (CPSs) represent the new generation of systems as the integration of computational and physical resources with significant computation, sensing, communication, and control capabilities. Noting the limited battery energy, limited memory, and finite spectrum available in each wireless sensor node, development of more efficient resource allocation methods becomes critical in these networks. The question is whether the physical layer presents more opportunities for efficient resource allocation or whether medium access control is the place to implement such methods, or perhaps higher layers. This chapter attempts to answer this question by reviewing the state of the art in the literature and proposing some new ideas and future research directions to complement recent results. In particular, we review recent game theory approaches that not only optimize key performance metrics under system constraints but also make a balance between the system overall efficiency and fairness in the resource allocation policy. This fundamental study involves new policy design for scheduling, routing, and transmission for basic multiple access scenarios. It paves the way for designing and optimizing next-generation networks with an arbitrary number of mobile nodes having a wide range of capabilities, such that the overall performance of the system is kept as high as possible while the nodes with poor local conditions do not deprive from basic service requirements. A comprehensive study of recent results in the literature is provided to put this multidimensional optimization problem into the right context. Various examples and scenarios are introduced and some approaches to analyze them are discussed.
The Kashmiri Language

In 1911, Grierson wrote a manual of “an interesting and little known tongue,” Kashmiri.1 Now more than eighty years later, it still remains interesting and yet little known. It is indeed unfortunate that after the monumental work done by Grierson around the turn of this century, the number of studies on Kashmiri that found their way into print remains abysmally sma11.2 Although Kashmiri has been influenced largely by other Indo-Aryan languages, it stands uniquely among its Indo-Aryan sisters on a number of phonological and morphosyntactic processes. In this chapter, I will discuss some salient characteristics of Kashmiri beginning with its sociolinguistic profile, continuing with its linguistic history, mainly, the controversy that sorrounds its genetic affiliation, and finally turning to the details of some aspects of its morphosyntactic structure that are, by and large, unique to it. The discussion of grammar will also facilitate comprehension of the data while, at the same time, serve as a reference tool for the remainder of the work.
Formation of the inner electron radiation belt by enhanced large-scale electric fields

A 2-dimensional bounce-averaged test particle code was developed to examine trapped electron trajectories during geomagnetic storms with the assumption of conservation of the first and second adiabatic invariants. The March 2013 storm was selected as an example because the geomagnetic activity KP index sharply increased from 2+ to 7- at 6:00UT on March 17. Electron measurements with energies between 37 and 460 keV from the Magnetic Electron Ion Spectrometer (MagEIS) instrument onboard Van Allen Probes (VAP) are used as initial conditions prior to the storm onset, and served to validate test particle simulations during the storm. Simulation results help to interpret the observed electron injection as non-diffusive radial transport over a short distance in the inner belt and slot region based on various electric field models, although the quantitative comparisons are not precise. We show that electron drift trajectories are sensitive to the selection of electric field models. Moreover, our simulation results suggest that the actual field strength of penetration electric fields during this storm is stronger than any existing electric field model, particularly for L ≤ 2.
PRO and (Under)Specification of Person in Imposter Constructions

This paper examines a particular type of English control constructions that exhibits morphosyntactic variation. The constructions that are investigated are control that appears in the imposter phenomenon studied by Collins & Postal (2012). Using minimalist syntax in combination with the framework of Distributed Morphology (DM), a syntactic account is offered that validates such variation and shows evidence for PRO in infinitives with imposter constructions, rather than a trace of NP via movement. Furthermore, comparing PRO and pro for the subject gap of control, it shows that PRO can account for binding alternations unlike pro. The current analysis demonstrates that the lack of the underspecification of phi-feature valuation does not result in ungrammaticality whereas the failure of Agree itself leads to ungrammaticality. Moreover, the current analysis offers a systematic picture of the morphosyntactic variation of English nominals in terms of the person feature and it also accounts for cross-linguistic morphosyntactic variation in agreement displayed in Chinese and Japanese.
1/ $f$ Noise in As-Processed and Proton-Irradiated AlGaN/GaN HEMTs Due to Carrier Number Fluctuations

We find that the low-frequency 1/ $f$ noise of AlGaN/GaN HEMTs before and after 1.8-MeV proton irradiation is more consistent with a carrier-number fluctuation model that includes a non-constant defect-energy distribution ${D}_{t}$ ( ${E}_{f}$ ) than with the Hooge mobility fluctuation model. A strongly varying ${D}_{t}$ ( ${E}_{f}$ ) in these devices is confirmed by measurements of the voltage and temperature dependence of the noise. First-order estimates of effective border-trap density before and after 1.8-MeV proton irradiation are obtained for commercial and research-grade devices using a simple number-fluctuation model. The input-referred noise magnitude of GaN/AlGaN HEMTs decreases at biases that are much more positive than threshold because the gated region of the HEMT comprises a relatively small portion of the channel, and the noise is attenuated by the voltage divider formed by the gated and ungated regions of the channel.
MONEY ILLUSION AND MARKET SURVIVAL

By studying complete and incomplete dynamic financial markets, I show that if some agents are money-illusioned and neglect inflation, the rational agents who are aware of inflation are driven out of the market in the long run, in the sense that the money-illusioned agents consume the economy's entire endowment. The reason for this finding is that with inflation, the money-illusioned agents always believe that the return on their savings is higher than it actually is. Because these agents trade financial assets in markets with the rational agents, the rational agents end up being borrowers and the money-illusioned agents lenders. Because the rational agents' debt accumulates over time, they become so indebted that the money-illusioned agents eventually consume the economy's entire endowment. If there is deflation, the opposite is true, and the rational agents evolutionarily dominate.
EFFECT OF STEREOCHEMISTRY IN ANIONIC POLYMERIZATION MODIFIERS

ABSTRACT The influence of stereochemistry of polar modifiers on the microstructure of polybutadiene and poly(styrene-co-butadiene) was evaluated for 2,2′-ditetrahydrofurylpropane (DTHFP). The meso and d,l diastereomers were isolated from commercial 50/50 mixtures through column chromatography and characterized by 1H-NMR and gas chromatography/mass spectrometry. The meso-DTHFP was found to be more active than d,l-DTHFP in incorporation of vinyl during anionic polymerization. To form a polymer with approximately 55% vinyl, twice the amount of d,l-DTHFP was required compared with using pure meso-DTHFP. The mechanism for this effect will be discussed.
Harassment and Mental Distress Among Adolescent Female Students by Sexual Identity and BMI or Perceived Weight Status.

Objective Sexual minority girls (lesbian/bisexual) and girls with overweight/obesity experience high rates of discrimination and mental distress. This study explored whether BMI or perceived weight status might compound sexual minority girls’ risk for harassment and mental distress. Methods Data on female students from the national 2015 Youth Risk Behavior Survey (n = 7,006) were analyzed. Logistic regression was used to examine differences in bullying, harassment, and mental distress across sexual identity/BMI groups: heterosexual/normal-weight, heterosexual/overweight, sexual minority/normal-weight, and sexual minority/overweight. Procedures were repeated with four analogous groups created from sexual identity and perceived weight. Results Across sexual identity/BMI groups, being overweight increased heterosexual females’ odds of being bullied or experiencing suicidal thoughts and behaviors. Regardless of weight status, sexual minority females had greater odds for each outcome than heterosexual females. Sexual minority females who perceived themselves as overweight had greater odds of suicidality than all other sexual minority/perceived weight groups. Conclusions Double jeopardy may exist for sexual minority female students who perceive themselves as overweight. Professional development with school staff on how to create a positive climate for sexual minorities and those with overweight/obesity and addressing positive identity and body image within school-based suicide prevention efforts may be important to the well-being of adolescent girls.
Ventriculoperitoneal Shunt-Associated Vancomycin-Resistant Meningitis Complicating a Patient Undergoing Plasmapheresis for Presumed Systemic Lupus Erythematosus-Associated Transverse Myelitis

Objectives We report a patient who had a working diagnosis of transverse myelitis secondary to a lupus exacerbation. As his clinical course evolved, continued vigilance clarified that he was in fact suffering from a nosocomial infection caused by vancomycin-resistant Enterococcus (VRE). Methods We performed a retrospective review of the patient's medical record. Results Despite radiographic improvement, he did not improve clinically following immunosuppressive therapy including plasma exchange. Once meningitis was diagnosed and treated, he improved rapidly. Conclusion The prospect of transverse myelitis may confound the diagnosis of VRE meningitis, a uniquely treated and potentially deadly infection.
Comprehensive analysis of pulmonary adenocarcinoma in situ (AIS) revealed new insights into lung cancer progression

Pulmonary adenocarcinoma in situ (AIS) is an intermediate subtype of lung adenocarcinoma that exhibits non-invasive growth patterns, but can develop into invasive. Almost 100% of AIS patients can be cured with complete resection. In contrast, the five-year survival rate for those diagnosed with invasive lung adenocarcinoma is only about 4%. In order to get a better understanding of adenocarcinoma and identify marks indicating its evaluation and progression, what needs to be done is a genome-wide evaluation of the disease. In this study, we used RNA-seq data from normal, AIS, and invasive lung cancer samples to identify gene module with differential gene expressions that represents the properties of AIS, distinct from normal and invasive tumor. Utilizing the differential expression patterns of protein-coding genes and long non-coding RNAs (lncRNAs) between AIS and other conditions, we obtained a small group of 72 AIS-specific genes consisting 41 protein-coding genes, 5 annotated lncRNAs, and 26 novel lncRNA transcripts that expressed specifically in AIS samples. We consider that twelve of the protein-coding genes are lung cancer driver genes with located driver somatic mutations. Moreover, these AIS-specific genes show capabilities (98% accuracy in an independent data set) for indicating early stage lung cancer and normal situations. These genes are determined based on cell-adhesion functioning, including angiogenesis and fibronectin, etc., that are highly related to cancer development. The comparison of AIS with normal and invasive tumor provides the gene list revealing the mechanisms that accounts for AIS progression to invasive cancer. Furthermore we identified important signatures contributing to the early diagnosis of lung cancer, providing auxiliary studies to our ongoing precision medicine research (http://americancse.org/events/csce2017/keynotes_lectures/yang_talk).
Immune-Related Adverse Events Associated with Immune Checkpoint Blockade

Side Effects of Immune Checkpoint Blockade The wide range of immune-related adverse effects associated with immune checkpoint blockade can complicate this effective therapy and limit its use in patients with cancer. This review surveys the adverse effects and their management.
Independent living services, adjudication status, and the social exclusion of foster youth aging out of care in the United States

ABSTRACTRecent policy changes have increased the availability of independent living services (ILS) to foster youth aging out of care in the United States. Yet, it is possible that youth who are als...
A tale of two rural cities: Dynamics of community capitals during a North Dakota oil boom

The Community Capitals Framework was used in this study to understand, compare, and contrast how an oil boom is changing the nature, character, and context of two rural cities, “Minor” and “Major.”...
Abstract 12974: Peak Calf Muscle Perfusion is Similar With Post-Occlusion Hyperemia and Exercise in PAD

Objective: Pulsed arterial spin labeling (PASL) is a non-contrast magnetic resonance imaging (MRI) technique that can be used to quantify calf muscle perfusion with stress. We hypothesized that post-occlusion hyperemia would yield greater flow compared to exercise in peripheral artery disease (PAD) and healthy subjects when measured by PASL. Methods: Twenty PAD patients (45% M) and 24 healthy subjects (50% M) were enrolled. Exercise was plantar flexion pedal ergometry to exhaustion. Occlusion was achieved by inflation of a thigh cuff to 200 mmHg for 5 minutes. Fifteen averaged PASL images were acquired using a single-shot echo-planar pulse sequence at peak exercise [14 healthy (Nl-Ex); 15 PAD (PAD-Ex)] or immediately after cuff deflation [10 healthy (Nl-Cuff), 5 PAD (PAD-Cuff)]. Regions of interest were drawn in each calf muscle group. The highest muscle flow was measured for exercise, while an average of all muscle groups was used for reactive hyperemia. Results: Healthy subjects were younger than PAD (53 ± 8 vs. 65 ± 9, p ≤ 0.001). Ankle-brachial index was similar between PAD groups (0.72 ± 0.12 vs. 0.68 ± 0.03, p = 0.54). Nl-Ex subjects exercised longer than PAD patients (631 ± 388 s vs. 218 ± 105 s, p ≤ 0.005). Perfusion was higher in Nl-Cuff than Nl-Ex (121 ± 35 vs. 78 ± 23 mL/min-100g, p ≤ 0.001), but similar in PAD-Cuff and PAD-Ex (45 ± 27 vs. 42 ± 15 mL/min-100g, p = 0.841) (Fig 1 - left, *p≤0.05 vs. Nl-Ex, ^ p=NS vs. PAD-Ex). Flow in both Nl groups was higher than PAD patients. Exercise yielded increased flow in the muscles utilized in both groups, whereas reactive hyperemia yielded a homogenous flow pattern in normal subjects (Fig 1 - right). In PAD patients, however, the flow increase was seen primarily in the soleus. Conclusions: In contrast to healthy subjects, cuff occlusion hyperemia in PAD yields peak flow similar to exercise when measured with PASL MRI. The lack of homogenous reactive hyperemia in PAD patients may be indicative of microvascular disease.
Structural Health Monitoring Through Chaotic Interrogation

The field of vibration based structural health monitoring involves extracting a ‘feature’ which robustly quantifies damage induced changes to the structure in the presence of ambient variation, that is, changes in ambient temperature, varying moisture levels, etc. In this paper, we present an attractor-based feature derived from the field of nonlinear time-series analysis. Emphasis is placed on the use of chaos for the purposes of system interrogation. The structure is excited with the output of a chaotic oscillator providing a deterministic (low-dimensional) input. Use is made of the Kaplan–Yorke conjecture in order to ‘tune’ the Lyapunov exponents of the driving signal so that varying degrees of damage in the structure will alter the state space properties of the response attractor. The average local attractor variance ratio (ALAVR) is suggested as one possible means of quantifying the state space changes. Finite element results are presented for a thin aluminum cantilever beam subject to increasing damage, as specified by weld line separation, at the clamped end. Comparisons of the ALAVR to two modal features are evaluated through the use of a performance metric.
The Cultural Contradictions of High Tech: Or the Many Ironies of Contemporary Technological Optimism

When I published my study of Technological Utopianism in American Culture in 1985, I thought that the historical phenomenon I detailed there — an uncritical faith in technology’s ability to solve all problems — would soon be a relic of a more hopeful, if more naive, era. I believed that increasing numbers of Americans, following the lead of Europeans and others, had begun to seek healthy limits on unadulterated technological advance and were starting to express greater concern for nontechnological realms crying out for equivalent attention, enthusiasm, and funding. I sensed movement toward what I called a “technological plateau.” I still do, but my optimism, never overwhelming, has since been tempered further.
A binary collision Monte Carlo model for temperature relaxation in multicomponent plasmas

Particle simulations with Monte Carlo collision models have been widely used to efficiently solve Coulomb collisions in plasma systems. A binary collision Monte Carlo model which has been proposed previously provides more accurate results than the commonly used Nanbu’s model for electron-ion temperature relaxation. In the present work, this binary model is generalized to simulate multicomponent plasmas, and its results still show higher accuracy than Nanbu’s model when compared to the baseline results obtained from Particle-Particle simulations. In addition, the binary model is improved to eliminate the time step length limitation occurred in the previous algorithm.
Ternary organic solar cells with small voltage losses (Conference Presentation)

The voltage loss in organic photovoltaics (OPVs) is defined as the difference between the open circuit voltage and the voltage offset between the lowest unoccupied molecular orbital (LUMO) of the acceptor and the highest occupied MO (HOMO) of the donor forming the charge dissociating heterojunction. Widely employed fullerene acceptors show significant voltage losses, approaching 0.8 V, thereby reducing the potential efficiencies of OPVs. In this work, we show that ternary blends of two non-fullerene acceptors with a polymer donor are effective in significantly reducing the voltage losses in near-infrared (NIR) OPVs. A narrow energy gap non-fullerene acceptor, FIDC, sharing similar HOMO energies with the acceptor BT-CIC [1], (absorption up to 1000 nm) is blended with the polymer PCE-10. The power conversion efficiency (PCE) of the ternary cell is increased from 10.7% in a BT-CIC:PCE-10 binary cell to 12.6% in the BT-CIC:FIDC:PCE-10 ternary cell. Further, the short-circuit current density is increased from 22.3 mA cm-2 to 25.5 mA cm-2. Importantly, the ternary cell decreased the voltage loss from 0.61 to 0.54 V. The ternary devices showed larger open circuit voltage of 0.70V than either the analogous BT-CIC (0.69 V) or FIDC (0.66 V) binary devices [2,3]. This work points to a simple means for increasing the materials available for spanning the visible and NIR spectra in very high efficiency, low loss OPVs. 1. Li, Y.; Lin, J.-D.; Che, X.; Qu, Y.; Liu, F.; Liao, L.-S.; Forrest, S. R. J. Am. Chem. Soc. 2017, 139, 17114. 2. Ameri, T.; Khoram, P.; Min, J.; Brabec, C. J. Adv. Mater. 2013, 25, 4245. 3. Fu, H.; Wang, Z.; Sun, Y. Solar RRL 2018, 2, 1700158.
Iterative design method of LCL filter for grid‐connected converter to achieve optimal filter parameter combination

This study proposes an iterative design method of L-type Inductor, Capacitor, and L-type Inductor (LCL) filter for grid-connected converter to achieve optimal filter parameter combination. LCL filter is commonly used for to reduce high frequency harmonic pollutions being injected into distributed power network. Accordingly, the performance of harmonics attenuation is taken as the most decisive constraint for filter parameter design. Usually, traditional methods apply the full-modulated operating condition to acquire amplitudes of present voltage harmonics, leading to over-designed capability of harmonics attenuation, which means increased inductance, degraded dynamic response, and enlarged weight and space. To deal with these challenges, the harmonic distortion factor is first proposed to evaluate the influence of different order voltage harmonic on grid current distortion. Also then, with four deduced constraint functions, an iterative design procedure is proposed to obtain satisfactory region of all filter parameters. As a result, the capability of harmonics attenuation can be precisely designed, and the optimal parameter combination brings about significant reduction of filter inductance. For instance, compared with the traditional method, the total inductance can be reduced by 23.3% in a 10 kW system. Finally, the experimental results are presented to demonstrate the effectiveness of proposed method.