cssi/SciSciGPT-SciSciNet huggingface dataset:
Outcomes following corticosteroid injection for temporomandibular joint arthritis in juvenile idiopathis arthritis

Results 47 patients (59% female) had a total of 71 joints injected. Pain and reduced jaw opening were the most common preceding symptoms. Mean age at JIA diagnosis was 9.3 years, and at time of TMJ injection was 12.8. Mean time between JIA diagnosis and first TMJ injection ranged from 0.9-14.5years. JIA subtypes were: oligoarticular (18.6%), extended-oligoarticular (16.5%), polyarticular (37.2%), enthesitis-related (9.3%), and psoriatic (18.6%). At the time of TMJ injection 18 patients were receiving methotrexate, 4 prednisolone, 1 etanercept and 1 leflunomide. 3 months after TMJ injection, 51% had complete resolution of symptoms, 44% had improved and 5% had no response. 36 patients had follow-up data at a mean of 2.5 years, showing complete resolution of symptoms in 29/36 (80.5%), improvement in 3/36 (8.3%) and no improvement in 4/36 (11.2%). No cases of micrognathia, Cushing’s syndrome, or subcutaneous atrophy were documented.
Painful Skin Ulcers in a Hemodialysis Patient

Calciphylaxis, also referred to as calcific uremic arteriolopathy, is a relatively rare but well described syndrome that occurs most commonly in patients with late stage CKD. It is characterized by very painful placques or subcutaneous nodules and violaceous, mottled skin lesions that may progress to nonhealing ulcers, tissue necrosis, and gangrene with a 1-year mortality rate >50%. The pathogenesis of calciphylaxis is poorly understood. Risk factors include female sex, obesity, hyperphosphatemia, hypercalcemia, hyperparathyroidism, longer dialysis vintage, hypercoagulable states, and use of calcium-containing phosphate binders and warfarin. Treatment strategies for calciphylaxis are limited by inadequate understanding of its pathophysiology. Therapy is generally focused on correcting disturbances of calcium, phosphorus, and parathyroid hormone metabolism. Additional therapy focuses on decreasing inflammation and on dissolution of tissue calcium deposits with sodium thiosulfate and/or bisphosphonates. Successful treatment generally results in improvement of pain and healing of the lesions within 2–4 weeks, but the disorder generally takes many months to completely resolve.
Absolute Hounsfield unit measurement on noncontrast computed tomography cannot accurately predict struvite stone composition.

Abstract Background: The purpose of our study was to determine, in vivo, whether single-energy noncontrast computed tomography (NCCT) can accurately predict the presence/percentage of struvite stone composition. Methods: We retrospectively searched for all patients with struvite components on stone composition analysis between January 2008 and March 2012. Inclusion criteria were NCCT prior to stone analysis and stone size ≥4 mm. A single urologist, blinded to stone composition, reviewed all NCCT to acquire stone location, dimensions, and Hounsfield unit (HU). HU density (HUD) was calculated by dividing mean HU by the stone's largest transverse diameter. Stone analysis was performed via Fourier transform infrared spectrometry. Independent sample Student's t-test and analysis of variance (ANOVA) were used to compare HU/HUD among groups. Spearman's correlation test was used to determine the correlation between HU and stone size and also HU/HUD to % of each component within the stone. Significance was conside...
Effectiveness of Nutrition Interventions in the Management of Malnourished Patients Treated With Maintenance Dialysis

Malnutrition is not uncommon in patients with end-stage renal disease treated with maintenance dialysis. In addition, malnutrition is associated with increased morbidity and mortality in these patients. A number of interventions have been undertaken to increase nutrient intake or to provide growth factors to induce anabolism. These interventions have met with varying degrees of success. The most efficient and effective method of managing malnutrition in the dialysis patient is still unclear. More research is needed to determine the most appropriate method of management of malnutrition.
RELATIONSHIP BETWEEN CONE CROP SIZE AND CONE DAMAGE BY INSECTS IN RED PINE SEED-PRODUCTION AREAS

Annual cone abundance and insect damage to cones are highly variable in red pine seed-production areas. Cone crop size fluctuates almost unpredictably from year to year, but the number of insect-attacked cones tends to increase annually unless limited by cone abundance. Sixty-six per cent of the variation in cone damage can be associated with variations in cone abundance. This information, coupled with the fact that red pine cone insects are almost entirely dependent on red pine cones for food, implies that crop size is highly important in regulating populations of cone insects. Insects will be most devastating in areas where crop size varies little from year to year.
Frequency domain results for systems with multiple time scales

The mathematical treatment of systems with multiple time scales has traditionally employed the use of singular perturbation theory for differential equations. This paper treats such systems from a frequency-domain viewpoint. Previously existing two-frequency-scale results, involving approximation and algebraic characterization, are extended. In addition, an exact frequency-scale decomposition is presented.
Understanding marketing’s philosophy debates

Purpose – The purpose of this article is to chronicle the publication events in the 1980s and 1990s that framed the development of the series of controversies in marketing that are known as the “philosophy debates”. Design/methodology/approach – The article uses a participant’s retrospective approach. Findings – The article finds that seven publication events are key to understanding marketing’s philosophy debates. The seven are the publication of the “little green book” by Grid, Inc. in 1976; the philosophy of science panel discussion held at the Winter American Marketing Association Educators’ Conference in 1982; the special issue of the Journal of Marketing on marketing theory in 1983; three articles on the “critical relativist perspective” by the Journal of Consumer Research in 1986 and 1988; the “blue book” by South-Western in 1991; a trilogy of articles on truth, positivism and objectivity in the Journal of Marketing and the Journal of Consumer Research in 1990-1993; and an article on “rethinking ma...
15. COOLING OF WHITE DWARFS

A knowledge of the precise relationship between the age and luminosity of a white dwarf can in principle be used to determine the compositions of the white dwarfs in galactic clusters. To this end the assumptions in Mestel's theory of white dwarf cooling are critically reviewed, and the results of recent work aimed at relaxing these restrictions are briefly summarized. It is concluded that on the basis of current knowledge an accuracy of the order of 10 or 20 % in the age­ luminosity relation should be attainable.
Reducing the Presumption of Arbitrability

The United States Supreme Court has expressed a "liberal federal policy favoring arbitration."1 However, under Gilmer v. Interstate/Johnson Lane Corp., arbitration agreements are only enforceable if "the prospective litigant effectively may vindicate [his or her] statutory cause of action in the arbitral forum."2 In Green Tree Financial Corp.-Alabama v. Randolph, the Supreme Court, applying Gilmer, held that plaintiffs could avoid arbitration by showing the "likelihood" of incurring prohibitive costs.3 The Courts of Appeals have split in interpreting Green Tree. In Bradford v. Rockwell Semiconductor Systems, Inc.,4 the Fourth Circuit focused on the individual litigant's ability to pay the costs of arbitration. The Fifth, Seventh, and Eleventh Circuits have followed suit.5 In contrast, the Sixth Circuit, in Morrison v. Circuit City Stores, Inc.,6 and the Third Circuit7 rejected the analysis in Bradford and held that the operative question is whether the costs of arbitration have "the 'chilling effect' of deterring a substantial number of potential litigants from seeking to vindicate their statutory rights."8 This Case Note argues that while the Bradford approach is more consistent with Green
Keynote speech IV sentiment analysis, lifelong learning, and intelligent personal assistants

Sentiment analysis (SA) or opinion mining is the computational study of opinions, sentiments, attitudes, emotions, moods and affects. Due to almost unlimited applications and numerous research challenges, SA is a very active research area in natural language processing and data mining. In this talk, I will first introduce the SA problem and discuss the recent work of using big data and lifelong learning to help solve the problem. I then discuss a consumer application of sentiment analysis. This naturally leads to the interesting topic of intelligent personal assistants such as Siri, Cortana, and Google Now, and Chatbots such as XiaoIce. I believe such systems will be the next big thing of AI and will profoundly change our lives. For these systems to be very useful and widely adopted, they need to perform extensive opinion, sentiment, and emotion analysis, and to converse with humans affectively.
Priority Disputes in the History of Psychology with Special Attention to the Franz–Kalischer Dispute About Who First Combined Animal Training with Brain Extirpation to Investigate Brain Functions

Shepherd Ivory Franz (American) and Otto Kalischer (German) each claimed to have been the first to combine animal training and brain extirpation to study brain function, a methodological approach that historians assert fundamentally changed subsequent neuropsychological research. Each defended his claim in 1907 in back-to-back commentaries in the journal Zentralblatt fur Physiologie. Before considering details of the Franz versus Kalischer dispute, it was deemed useful to consider priority disputes in general and to revisit the priority claims for who discovered the “conditioned reflex” and whether Pierre Flourens was the “father” of brain extirpation as examples of this type of research. Consideration of the Franz–Kalischer dispute began with a brief history of the study of brain function to provide background and context for the Franz–Kalischer dispute. For additional context, biographic sketches of Franz and Kalischer are presented. Then, details of the dispute are presented and discussed followed by conclusions that include that Franz (The American Journal of Physiology, 8, 1–22, 1902) preceded Kalischer (1907a) and that it is highly unlikely that anyone before Franz had used his combination of innovative methods. Finally, the perceived importance of being first to combine animal training with brain extirpation is represented by quotations from several authors of history or psychology textbooks and one author of a history of neuroscience textbook.
Recommitment of NRRMDD Defendants

### NRRMDD Defendants May Be Recommitted Using the Preponderance-of-the-Evidence Standard In Ernst J. v. Stone , 452 F.3d 186 (2nd Cir. 2006), the U.S. Court of Appeals for the Second Circuit affirmed a U.S. district court's denial of a petition for a writ of habeas corpus in which the petitioner,
Weighted Implementation of Suboptimal Paths (WISP): An Optimized Algorithm and Tool for Dynamical Network Analysis.

Allostery can occur by way of subtle cooperation among protein residues (e.g., amino acids) even in the absence of large conformational shifts. Dynamical network analysis has been used to model this cooperation, helping to computationally explain how binding to an allosteric site can impact the behavior of a primary site many angstroms away. Traditionally, computational efforts have focused on the most optimal path of correlated motions leading from the allosteric to the primary active site. We present a program called Weighted Implementation of Suboptimal Paths (WISP) capable of rapidly identifying additional suboptimal pathways that may also play important roles in the transmission of allosteric signals. Aside from providing signal redundancy, suboptimal paths traverse residues that, if disrupted through pharmacological or mutational means, could modulate the allosteric regulation of important drug targets. To demonstrate the utility of our program, we present a case study describing the allostery of HisH-HisF, an amidotransferase from T. maritima thermotiga. WISP and its VMD-based graphical user interface (GUI) can be downloaded from http://nbcr.ucsd.edu/wisp.
Alloy Thin Films from Discrete Metallaborane Clusters

The ferraborane HFe4 (CO)12 BH2 sublimes at 50 °C and decomposes by loss of H2 and CO on various substrate surfaces at 160–180 °C to yield films having metallic appearances with typical thicknesses of 4000A. These films are amorphous by X-ray, conduct electricity and adhere well to glass, metal and silicon substrates. The composition was determined by ESCA and Auger spectroscopies. The films exhibit highly uniform composition and the Fe/B ratio is 4 showing that film stoichiometry is defined by the cluster core. The ESCA chemical shifts show the presence of boride and metallic iron. At present the bulk film contains a high level of oxygen in the form of iron and boron oxides. No ax-iron is present by X-ray or Mossbauer spectroscopies. Some carbon and hydrogen (SIMS) are present. Mossbauer spectra show the presence of magnetic iron similar to that exhibited by authentic Fe80 B20 samples but the films also contain substantial paramagnetic iron.
Treatment of acute myeloid leukemia with antecedent myelodysplastic syndrome.

Primary myelodysplastic syndrome (MDS) and acute myeloid leukemia (AML) are both age-related, with increasing prevalence over age 60. The poor outcome of treatment for elderly AML patients is due both to host-related and Intrinsic biologic factors. Some elderly patients have documented MDS for months or years before presenting with AML. Many more, though, have dysplastic morphology in bone marrow and blood cells that suggests an occult preleukemic phase. Cytotoxic chemotherapy in elderly patients has a high morbidity and mortality due to comorbid diseases, diminished tolerance to prolonged pancytopenia, and decreased drug metabolism and excretion ; doses, therefore, are often attenuated. The low response rates to conventional remission-induction chemotherapy regimens suggest both intrinsic drug resistance and diminished normal hematopoietic precursors to regenerate following therapy. Less intensive chemotherapy has the potential for less organ toxicity, less hospitalization, and less expense. However, attenuated chemotherapy has the major disadvantage of less antileukemic activity and, as yet, the survival benefit for this approach remains unproven. Nevertheless, low-dose ara-C (cytarabine) therapy for 2 to 3 weeks may be beneficial for some patients. The standard response criteria used with acute leukemia to measure disease eradication may not be appropriate for patients with MDS evolving to AML.
What becomes an icon most

Some brands become icons. Think of Nike, Apple, Harley-Davidson: They're the brands every marketer regards with awe. But they are not built according to the principles of conventional marketing, says Harvard Business School marketing professor Douglas Holt. Iconic brands beat the competition not just by delivering innovative benefits, services, or technologies but by forging a deep connection with the culture. A brand becomes an icon when it offers a compelling myth, a story that can help people resolve tensions in their lives. The deepest source of tension in modern society is the disparity between national ideology and the average citizen's reality. When ideologies shift, myths become even more important, and in America, the most potent myths are depictions of rebels. Mountain Dew has long offered a rebel myth in ads showing exciting, vital men who are far from the ideological model of success. Loyal customers drink the beverage to consume the myth. But Mountain Dew's greatest achievement is that it has retained its iconic power by creating fresh rebel myths to suit the tensions of each era: first the hillbilly, who stood in stark contrast to the organization man of the 1950s and 1960s; then the redneck, who rebelled against the investment bankers and consultants of the 1970s and 1980s; and most recently the slacker, who rejects the values and behaviors that, for the past decade, have marked the successful executive. Holt says marketers can learn from Mountain Dew and other iconic brands if they are willing to move beyond conventional brand management and acquire knowledge and skills they may not have. They must learn to target national contradictions instead of just consumer segments, create myths that make sense of confusing societal changes, and speak with a rebel's voice.
The Next Frontier: Projecting the Effectiveness of Broad-scale Forest Conservation Strategies

Conservation and land management organizations such as The Nature Conservancy are developing conservation strategies to distribute protection efforts over larger areas and a broader range of ownership and management techniques. These “distributed conservation strategies,” such as working forest conservation easements, are based on the premise that blending resource extraction, such sustainable timber harvest, and conservation should yield greater socio-economic benefits without significantly compromising the conservation of biodiversity or the sustainable provisioning of ecosystem services. However, it is unknown how well these strategies will compare to traditional conservation preserves or if they will be robust to climate change and resource demand over the coming centuries. Due to scarce financial resources and the relative difficulty of negotiating easement acquisitions, it is important for forest conservation and management organizations to know which strategies most effectively meet conservation goals. Meanwhile, the long duration required to evaluate most monitoring questions leads to a lag in knowledge transfer and delayed adaptive management. In this chapter, we discuss the challenges and constraints to measuring conservation effectiveness and illustrate a scenario-building approach that we are applying to understand and compare the conservation effectiveness of various conservation strategies in two large conservation acquisitions in the Great Lakes region of the United States. We show how this approach can be used to evaluate potential outcomes for biodiversity and the provision of ecosystem services resulting from varying conservation strategies and discuss implications of this approach for the future of forest conservation.
Orientation of nonspherical particles

Introduction Elongated magnetizable particles respond to a magnetic field by aligning with their longest axes parallel to the field vector. This phenomenon is exploited in the familiar physics demonstration where iron filings are sprinkled on a sheet of paper placed atop a permanent magnet. As they land on the paper, the particles align themselves parallel to the field of the magnet and, if care is taken to distribute the particles uniformly, their pattern reveals the form of the magnetic field. Very similar behavior is manifested by elongated dielectric or electrically conductive particles in an electric field. The physical origin of the orientational torque exerted on a particle is closely related to that of rotational torque discussed in Chapter 4 and, in fact, a particle may exhibit a combination of rotational dynamics and orientational behavior under certain conditions. There are, however, some important distinctions to be drawn between the two effects. An orientational torque acts only upon a particle exhibiting some type of anisotropy due to either intrinsic properties such as crystalline anisotropy or extrinsic factors such as shape. Rotational torque, on the other hand, can be experienced by a spherical isotropic particle. In a rotating field, the orientational torque can produce steady motion, but only at synchronous speed. In contrast, rotational torque induces steady rotation at sub-synchronous speed. Orientational torque does not depend on either dielectric or ohmic loss, while rotational torque requires it. Particles can experience orientational torque in both AC and DC electric fields. With the exception of the Quincke effect (c.f., Section 4.4), steady rotation is ordinarily observed only with an AC field.
Sports Economics: The Business of Sports

Introduction As fans, we are most interested in the action on the field or in the arena because that is where the excitement takes place. We crave “the thrill of victory and the agony of defeat,” as ABC's Wide World of Sports television program put it. But sports is a big business that has some interesting economic characteristics. Sports businesses take many forms depending on the segment of the industry. Sports franchises in the professional leagues are athletic teams on the field, but they are businesses off the field, selling tickets, food and drinks, logoed apparel, parking, souvenirs, and broadcast rights. In individual sports, such as bowling, golf, tennis, and track, the athletes have their own businesses in a very real sense; they are sole proprietors with profits and losses based on earnings or winning, and expenses of many kinds. Athletes need facilities – bowling alleys, tennis courts, golf courses, arenas, ballparks, and tracks – and these are also businesses in their own right. Similarly, athletes need equipment – balls, bats, helmets, shoes, uniforms – and equipment manufacturers are obviously businesses. Advertisers, broadcasters, concessionaires, sports agents, and apparel manufacturers are all involved in some aspect of the business of sports. Amateur sports are also big businesses. The National Collegiate Athletic Association (NCAA) members manage substantial athletic budgets and must make business decisions on a daily basis. These decisions include hiring and firing coaches, picking corporate sponsors, investing in new or expanded training facilities, adding or deleting a sport, and pricing tickets, among many other things. On a smaller scale, high school athletic directors, recreational league directors, local Little League organizers, and the like are in the same boat.
A Pilot Study of Transformational Leadership and College Counseling Outcomes

ABSTRACTThis pilot study explores the relationship between perceived transformational leadership skills of college counselors and outcomes in counseling. College students receiving counseling (n = 46) were given a revised version of the Multifactor Leadership Questionnaire (MLQ), the Working Alliance Inventory, Short Form (WAI-S), and the Counseling Center Assessment of Psychological Symptoms (CCAPS-34). Results yielded significant relationships between improvement in areas of client functioning and subscales measuring aspects of transformational leadership in counselors as perceived by clients. In addition to significant correlations between alliance and subscales of the MLQ, there were strong negative relationships between social anxiety and management by exception (active); academic distress and idealized influence (behavior); and alcohol use and management by exception (passive).
Tunable pressure sensing applications of a MEMS buckled membrane

Buckled membranes are commonly used in microelectromechanical systems (MEMS) structures. One application of a microfabricated membrane is pressure sensing. A differential pressure across the membrane causes deflection, up or down, which can be measured and related to a specific pressure change. Recent work has demonstrated that the deflection and stiffness of these membranes can be tuned through localized joule heating. This opens up a wider range of possible applications of these membranes. In typical pressure sensor design, the mechanical properties of the membrane are constant resulting in a limited range of response to pressure. By tuning the stiffness of the membrane, its pressure response is varied providing a wider range of application for the pressure sensor. A 1.5mm by 1.5mm square membrane demonstrated a decrease in pressure sensitivity from 6μm/psi to 0.2μm/psi over a range of 0 to 15 volts applied to an electrothermal heater on top of the membrane.
Biotransformation (Metabolism) of Pesticides

This chapter provides an extensive summary of phase I and phase II metabolism of pesticides with particular reference to metabolism in the liver and extrahepatic tissues of mammals, the latter including lung, nasal tissues, skin, kidney, and the central nervous system. Detailed information is presented on human metabolism of pesticides. Information is also included on physiological factors affecting metabolism such as development, age, and gender, as well as variation between individuals and within strains and species, and on the toxicity of metabolites. Tolerance and resistance to pesticides are also briefly considered.
Off-Label Use of Aortic Devices and Parallel Stent Grafts for Iliac Revascularization

One-third of the patients treated for abdominal aortic aneurysms (AAAs) with endovascular aortic aneurysm repair (EVAR) have ectatic or aneurysmal common iliac arteries. Exclusion of the internal iliac arteries has been widely utilized, but carries a definite risk of buttock claudication or ischemic pelvic complications. The off-label use of approved stent grafts to preserve internal iliac artery flow has originated from the lack of widespread access to specifically designed iliac branch devices (IBDs). This chapter summarizes basic concepts and techniques of iliac parallel stent grafts.
Students helping students: vertical peer mentoring to enhance the medical school experience

Abstract Background Effective mentoring is an important component of medical student professional development. We provide a description of the mentoring program at our institution. Methods Our institution UTHSCSA implemented a student-advising program (Veritas) with clinical faculty mentors and senior students (MiMs). The MiMs provided vertical peer mentoring to more junior students as an adjunct to faculty advising. The MiMs lead small group discussions that foster camaraderie, share academic and career information and promote professional identity. An optional MiM elective more intensively develops mentorship and leadership skills through a formal curriculum. The authors used annual survey data of all students as well as student mentors to evaluate program effectiveness. Results Overall, student perception of the program improved each year across multiple domains, including feeling more prepared, supported and satisfied with their overall experience in medical school. Student mentors also found the process rewarding and helpful to their future careers as physicians. Conclusions The authors suggest implementing a vertical peer-mentoring program can be an effective adjunct to faculty mentoring.
Reexamining the Role of Electroconvulsive Therapy in Anorexia Nervosa in Adolescents

Electroconvulsive therapy (ECT) is rarely, if ever, considered for the treatment of severe anorexia nervosa (AN) or other eating disorders comorbid with an affective illness. Mood disorders are common in these patients, and psychotropic medications, although frequently used, have limited evidence of benefit in AN or copresenting depressive symptoms. Even when the illness is life threatening, ECT as a treatment may be overlooked. We present a case of an adolescent girl with severe AN and comorbid major depressive disorder with suicidality. This patient failed multiple medication trials but went on to experience complete remission from both the symptoms of her AN and major depressive disorder after undergoing a course of bilateral ECT. Electroconvulsive therapy may prove to be a fast and effective treatment strategy for mood disorders and suicidality in the setting of comorbid AN in adolescents.
Automated speech understanding: the next generation

Modern speech understanding systems merge interdisciplinary technologies from Signal Processing, Pattern Recognition, Natural Language, and Linguistics into a unified statistical framework. These systems, which have applications in a wide range of signal processing problems, represent a revolution in Digital Signal Processing (DSP). Once a field dominated by vector-oriented processors and linear algebra-based mathematics, the current generation of DSP-based systems rely on sophisticated statistical models implemented using a complex software paradigm. Such systems are now capable of understanding continuous speech input for vocabularies of several thousand words in operational environments. The current generation of deployed systems, based on small vocabularies of isolated words, will soon be replaced by a new technology offering natural language access to vast information resources such as the Internet, and provide completely automated voice interfaces for mundane tasks such as travel planning and directory assistance.
Teachable Moments in Human Resource Management: National Culture, Organizational Culture, and Intersectionality

The most important outcome of any academic course is to increase understanding for both learners and their instructors. However, in many business courses this is made problematic because of the ways in which business schools have constructed the bodies of knowledge that they consider relevant. This chapter considered the ways in which the Human Resource Management (HRM) course has evolved and argues that in its trajectory it has become artificially separated from many other critical understandings and bodies of knowledge, particularly those of national and organizational cultures. However, within the teaching and learning of HRM there are many opportunities for considering overarching perspectives, integrating what have become separated aspects, and providing the richer and more expansive understanding of subject matter that is increasingly demanded from business graduates in the complex and globalized world of work. The chapter explores the nature, significance, and potential of these opportunities—opportunities that are generally understood as teachable moments.
Kinetic Characterization of Prenyl-Flavin Synthase from Saccharomyces cerevisiae

We have characterized the kinetics and substrate requirements of prenyl-flavin synthase from yeast. This enzyme catalyzes the addition of an isopentenyl unit to reduced flavin mononucleotide (FMN) to form an additional six-membered ring that bridges N5 and C6 of the flavin nucleus, thereby converting the flavin from a redox cofactor to one that supports the decarboxylation of aryl carboxylic acids. In contrast to bacterial enzymes, the yeast enzyme was found to use dimethylallyl pyrophosphate, rather than dimethylallyl phosphate, as the prenyl donor in the reaction. We developed a coupled assay for prenyl-flavin synthase activity in which turnover was linked to the activation of the prenyl-flavin-dependent enzyme, ferulic acid decarboxylase. The kinetics of the reaction are extremely slow: kcat = 12.2 ± 0.2 h–1, and KM for dimethylallyl pyrophosphate = 9.8 ± 0.7 μM. The KM for reduced FMN was too low to be accurately measured. The kinetics of reduced FMN consumption were studied under pre-steady state con...
Sinking Skin Flap Syndrome Presenting with Cranial Neuropathies (P6.063)

Objective: To report a case of sinking skin flap syndrome with cranial neuropathies Background: Sinking skin flap syndrome or “syndrome of the trephined” can occur in patients with prior hemicraniectomies in the setting of post-operative lumbar puncture or ventriculoperitoneal shunt placement. The etiology may be due to the reduction of intracranial pressure relative to atmospheric pressure resulting in intracranial hypotension. A variety of symptoms have been reported including headaches, unilateral weakness or numbness, lethargy, and seizures. However, cranial neuropathies have not been previously reported. Design/Methods: A 26 year old male with a history of a left temporo-parietal ruptured arteriovenous malformation requiring hemicraniectomy presented one month postoperatively with headaches and subjective fevers. A lumbar puncture to rule out meningitis demonstrated no significant abnormalities, and the patient was discharged home. He returned to the emergency room with worsening headache and neck stiffness the following day. He was admitted for presumed meningitis and developed significant right ptosis and double vision. He had bilateral third nerve palsies (right eye dilated, with restricted adduction, elevation, and depression in both eyes), right hemiparesis, and (mild) lethargy. During admission, these symptoms progressed without signs of infection. Results: MRI of the brain with contrast demonstrated interval sinking of the skin flap, left to right midline shift, medial displacement of the left uncus, enlargement of the dural venous sinuses, and enhancement of the meninges consistent with intracranial hypotension. The patient was taken for emergent blood patches with resolution of his headache as well as significant improvement of his ptosis, anisocoria, and extraocular eye movements. Conclusions: Sinking skin flap syndrome can present with cranial nerve palsies in addition to sensory, motor and cognitive deficits. It is important to recognize the syndrome early as it can be reversed with interventions, such as blood patches and cranioplasty. Disclosure: Dr. Tiongson has nothing to disclose. Dr. Kim has nothing to disclose. Dr. Grossman has nothing to disclose. Dr. Thawani has nothing to disclose.
Graph-Theoretically Optimal Memory Banking for Stencil-Based Computing Kernels

High-Level Synthesis (HLS) has advanced significantly in compiling high-level "soft»» programs into efficient register-transfer level (RTL) "hard»» specifications. However, manually rewriting C-like code is still often required in order to effectively optimize the access performance of synthesized memory subsystems. As such, extensive research has been performed on developing and implementing automated memory optimization techniques, among which memory banking has been a key technique for access performance improvement. However, several key questions remain to be answered: given a stencil-based computing kernel, what constitutes an optimal memory banking scheme that minimizes the number of memory banks required for conflict-free accesses? Furthermore, if such an optimal memory banking scheme exists, how can an FPGA designer automatically determine it? Finally, does any stencil-based kernel have the optimal banking scheme? In this paper we attempt to optimally solve memory banking problem for synthesizing stencil-based computing kernels with well-known theorems in graph theory. Our graph-based methodology not only computes the minimum memory partition factor for any given stencil, but also exploits the repeatability of coloring entire memory access conflict graph, which significantly improves hardware efficiency.
Social cognition moderates the relationship between neurocognition and community functioning in bipolar disorder

Abstract Background Schizophrenia (SZ) studies suggest that neurocognition predicts functional outcome and that social cognition mediates this relationship. Bipolar disorder (BD) patients also have cognitive, social, and functional impairments but the relationship among these factors in BD is not well established. We assessed whether social cognition modulates the influence of neurocognition on community functioning in BD, as found in SZ. Methods 200 BD patients and 49 healthy controls (HC) were administered and compared on a battery of tests assessing neurocognition, social cognition, and community functioning. We conducted a series of regression analyses to investigate potential mediation or moderation of social cognition on the relationship between neurocognition and community functioning. Results BD patients performed worse on neurocognitive domains of processing speed, attention, verbal learning, and global neurocognition. Also, BD patients performed worse on theory of mind, the social cognition composite score, and community functioning. Neurocognition did not significantly predict functional outcome in our BD sample. However, we found a moderating effect of social cognition: among patients with poor social cognition, better neurocognition was associated with better community functioning, a relationship not seen in BD patients with good social cognition. Limitations The study was limited by a relatively small HC group and assessing one subtype of functioning status. Conclusions The relationship between neurocognition and community functioning in BD may be dependent on social cognition status, implying the presence of social cognitive heterogeneity. Results may be relevant to choosing proper treatment interventions depending on the patient's social cognitive level.
The impact of study away in the Fashion Merchandising curriculum informed by student and alumni experience

The purpose of this study is to explore links between the knowledge/skills graduating seniors and alumni perceive they acquired in a Fashion Merchandising program and relationships with participation in a study away program. Findings are expected to inform study-away infused curriculum development and strengthen knowledge/skills needed for the workplace. Of the 215 respondents (64.5% graduating seniors and 35.5% alumni), more than half had experienced a study away program. The student and alumni group who studied away provided significantly different ratings of knowledge and skills gained in critical thinking skills (p=.02), writing ability (p=.05), and artistic skills (p=.05). These findings align with ITAA Meta-Goal Competencies of Critical thinking, Leadership/management, and Analysis/synthesis, further justifying a study away curriculum requirement. Future studies are encouraged to investigate specific components of the study away experience and its relationships with critical thinking skills, writing skills, and artistic ability to further develop curriculum and implement in course learning objectives.
High-Intensity Beams

We have discussed the role of the beam’s own space charge as a source of aberrations in Section 5-6-2. We know that space charge has two basic forms: distributed charge and interactions of individual particles. In this chapter the problem of distributed space charge will be considered in some detail, followed by a short discussion of the Boersch effect.
iHTTP: efficient authentication of non-confidential HTTP traffic

HTTPS is the standard protocol for protecting information sent over the World Wide Web. However, HTTPS adds substantial overhead to servers, clients, and networks [1, 2]. As a result, website owners often pass on HTTPS and resort to only HTTP for hosting websites, leaving clients and servers vulnerable to attacks [3, 4]. Techniques have been proposed to only enable authentication and integrity of HTTP (response) data [2, 5---7]. However, they all suffer from vulnerabilities and poor performance. In this paper, we propose iHTTP, a new approach for enabling lightweight, efficient authentication and verification of HTTP (response) data. We adaptively handle different data encodings to allow for better performance without effecting user experience. We introduce a novel technique, Sliding-Timestamps, to allow iHTTP clients to authenticate the freshness of response data to prevent replay attacks and amortize signing costs. We also introduce Opportunistic Hash Verification to reduce client public key operations required to authenticate full web pages. We show in our experimental evaluation that iHTTP provides similar performance to HTTP, and higher throughput and lower maximum response time than HTTPS and HTTPi, the most recent HTTP authentication approach [7], for Client-Static data.
Muscle disease in scleroderma.

Purpose of review This review discusses the most updated literature of muscle disease in scleroderma in the past year. Recent findings In the past year, two studies have highlighted that fibrosis is a prevalent histopathologic feature in muscle biopsies of patients with scleroderma muscle disease. In addition, microangiopathy was a common co-feature on muscle biopsies. A fibrosing myopathy, or fibrosis predominance on muscle histopathology, is associated with a unique clinical phenotype in patients with scleroderma. When compared with those with an inflammatory myopathy, patients with a fibrosing myopathy tend to have diffuse scleroderma, lower muscle enzymes, nonirritable myopathy, and elevated cardiac enzymes. These patients are also reported to have a higher risk of cardiopulmonary complications and cardiac death when compared with those with an inflammatory myopathy. Summary Although there are clear cases of overlap myositis, it is clear that muscle disease in scleroderma is being redefined, and it is crucial to start recognizing that the muscle is an organ that can directly be affected by scleroderma. Fibrosis can occur early in scleroderma muscle disease, and a unique histologic subtype of muscle disease, fibrosing myopathy, is associated with a higher risk of mortality.
Analysis for Science Librarians of the 2018 Nobel Prize in Chemistry: Directed Evolution of Enzymes and Phage Display of Peptides and Antibodies

The 2018 Nobel Prize in Chemistry recognized three scientists for harnessing evolutionary mechanisms to create molecules capable of new and specific chemical reactions. George Smith and Gregory Win...
ALBUMIN LEVEL AS A RISK MARKER AND PREDICTOR OF PERIPARTUM CARDIOMYOPATHY

Low albumin is independent risk factor for incident heart failure, however the association of low albumin and development of Peripartum Cardiomyopathy (PPCM) is not known Logistic regression was used to investigate the relationship between second trimester albumin levels (continuous variable) and
Capra hircus (Goat)

Identification of the X chromosome by morphology alone is unreliable. Hauschteck-Jungen and Meili found that X of C. ibex is the second longest of the haploid set and that the karyotypes of C. hircus and C. ibex are identical. Taylor et al. considered the longest element as the X. From H3 thymidine autoradiographs, Evans identified the X as the third largest. The chromosomes of the karyotypes shown here are overcondensed, so that recognizing the X is more subjective. Thymidine autoradiography is probably the only method to identify the X positively in the female.
Critical components of interventions to promote resilience among children with maltreatment experiences: A qualitative study of practitioners’ perspectives

Abstract Although researchers and practitioners keep working on identifying efficacious interventions for children with maltreatment experiences, few studies explore the perspective of the clinicians for their perspective of the critical components of interventions to promote resilience among maltreated children. To address this research gap, 27 interviews were conducted with clinicians to examine the critical components that should be incorporated into interventions. Four primary themes were captured from practitioners’ perspective: (1) therapist characteristics; (2) caregiver characteristics; (3) community influences; and, (4) post-treatment support. Findings of this study benefit the improvement of future clinical interventions to promote the resilience of maltreated children.
Perceived abortion stigma and psychological well-being over five years after receiving or being denied an abortion

Author(s): Biggs, M Antonia; Brown, Katherine; Foster, Diana Greene | Abstract: OBJECTIVE:To prospectively assess perceptions of abortion stigma after receiving or being denied an abortion over 5 years, the factors associated with perceived abortion stigma, and the effects of perceived abortion stigma on psychological well-being. METHODS:We recruited people seeking abortion from 30 facilities across the US, and interviewed them by phone one week post-abortion seeking, then semiannually for 5 years. We used adjusted mixed effects regression analyses to examine the abortion stigma trajectories of those who obtained an abortion near a facility's gestational age limit (Near-limits) compared to those denied an abortion because they were just over the limit and carried their pregnancies to term (Turnaway-births). RESULTS:Of the 956 people recruited, we removed 28 due to ineligibility or missing data, leaving a final sample of 928. In unadjusted analyses, at one-week post-abortion seeking, over half of those seeking abortion perceived that if others knew they had sought an abortion, they would be looked down upon at least "a little bit" by people close to them (60%) or by people in their community (56%). In longitudinal adjusted analyses, people denied an abortion and who carried their pregnancies to term (Turnaway-birth group) reported significantly lower baseline perceived abortion stigma from people close to them (-0.38; 95% CI, -0.59, -0.16) and from people in their community (0.30; 95% CI, -0.52, -0.08), than Near-limits, differences that remained statistically significant for 1.5 years. Overall perceived abortion stigma declined significantly (p l .001) for both study groups. High perceived abortion stigma at baseline was associated with higher odds of experiencing psychological distress years later (adjusted Odds Ratio, 3.98; 95% CI, 1.39, 11.37). CONCLUSIONS:Most people considering abortion perceive some abortion stigma, which is associated with psychological distress years later.
Uncovering Factors Influencing Instructors' Decision Process when Considering Implementation of a Course-Based Research Experience.

This paper discusses the results of a qualitative study, framed in diffusion of innovations theory, which explores the decision-making process of undergraduate instructors interested in implementin...
Barriers to goals of care discussion and early palliative care referral in patients with advanced cancer: A community oncology clinic survey.

e19199Background: Earlier discussion of end-of-life (EOL) preferences in patients with advanced cancer is associated with less aggressive EOL care. Most terminally-ill patients have not discussed t...
The Impact of the Facebook Court Order & CCPA 2020: Helping Businesses and Accountants Meet the Challenge of the New Era of Privacy Compliance

The regulatory and compliance environment regarding privacy issues has changed drastically in the past few years. With the California Consumer Privacy Act becoming effective on January 1, 2020 and the Federal Trade Commission’s imposition of a $5 billion fine on Facebook for privacy violations on July 24, 2019, companies that utilize customer data are now finding themselves reevaluating their privacy practices. This article provides businesses and accountants with solutions to address these new privacy issues. First, the paper analyzes the new legal framework of the CCPA and the FTC’s action. Next, advice is provided for businesses to comply with the CCPA and respond to consumer requests for information. The paper concludes with a practical implementation plan for businesses to adopt.