cssi/SciSciGPT-SciSciNet huggingface dataset:
Contextually Reconstructing Miss America: Utilizing Blended Methods to Critique the Oratory of Pageant Titleholders

Recently, U.S. American pageant systems have worked to redefine their cultural position as state titleholders within these systems are thrust into the public dialogue. However, the unique rhetorical artifact that is titleholder oratory coupled with the dynamic public address contexts in which titleholders locate themselves demands a blurring of lines between texts and performance of textuality due to cultural status as pageant winners. This oratory, then, becomes a deserving artifact of study, necessitating fresh forms of criticism. This essay champions the study of pageant titleholder oratory and proposes a mixed methodology of autoethnographic rhetorical criticism to authentically evaluate the contextual reconstruction pageant titleholders undergo in their varied oratorical contexts. Additional suggestions regarding transferability of this method to similar orators and oratorical contexts are also provided.
Global Justice Movement

The Global Justice Movement (GJM) is an umbrella term for the diverse and amorphous set of associated and loosely networked organizations, groups, and movements – mostly from the political left – including anti-war, labor, environmental, feminist, peasant, indigenous, and student groups, that oppose corporate globalization and neoliberal capitalism, imperialism, and war. The GJM, which arguably peaked around the turn of the twenty-first century, signifies a new cycle of contention. Distinct yet related to past movements and protest cycles, the GJM embraces novel tactics and strategies as well as organizing models. Emerging in the wake of the implementation and consolidation of global neoliberal restructuring policies, the GJM has organized and mobilized for massive protests (e.g., the “Battle for Seattle” in 1999) and initiated the World Social Forum, which has spurred social forums across the globe. The “Arab Spring” and Occupy Wall Street, as well as more recent anti-austerity protests, can all be seen as part or outgrowths of the GJM's cycle of protest. Keywords: capitalism; democracy; globalization; inequality; social change; social movements
Investigation of the hyper-reflective inner/outer segment band in optical coherence tomography of living frog retina

This study is to test anatomic correlates, including connecting cilium (CC) and inner segment (IS) ellipsoid, to the hyper-reflective band visualized by optical coherence tomography (OCT) and commonly attributed to the photoreceptor inner/outer segment (IS/OS) junction. A line-scan OCT (LS-OCT) was constructed to achieve sub-cellular resolution (lateral: ≈ 2 μm; axial: ≈ 4 μm) of excised living frog retinas. An electro-optic phase modulator was employed for rapid and vibration-free phase modulation. Comparison of normalized distance measurements between LS-OCT images and histological images revealed that the dominant source of the signal reported as the IS/OS OCT band actually originates from the IS.
Syntheses of amino ethers with potential pharmacological activity.

Abstract A number of potentially active modifications of the basic amino-ether structure R-O-CH 2 CH 2 -N-R'R" (when R is alkyl or aryl) were prepared in a study of structure-histaminolytic activity correlation. Although the R group was considered the principal determinant of activity and subject to the most modifications, variation in the amine moiety and elsewhere were also made. Water-soluble salts of the new bases were also prepared in the usual manner
Assessing Ecological Restoration Potentials of Wisconsin (U.S.A.) Using Historical Landscape Reconstructions

Historical landscape reconstructions provide baseline information for evaluating current land management regimes and restoration potentials. We assessed the historical landscape composition and structure of the state of Wisconsin (U.S.A.). This knowledge forms a basis for delineation of potential spatial distribution of forest species and landscape structures before major humaninduced changes, quantification of the spatial extent and intensity of change in habitats and landscapes, and identification of target areas for ecological restoration (e.g., threatened ecosystems). Methods included two conceptuallyandmethodologicallydifferentvegetationclassifications. The classifications rely on the original U.S. Public Land Office Surveys conducted during the nineteenth century to sell land to Euro-American settlers. The subjective classification method we examined was R. W. Finley’s ‘‘Original Vegetation of Wisconsin.’’ This classification accounts for qualitative information such as early land surveyors’ descriptions of ecosystems (e.g., distinctions into wet and dry prairies). However, the classification is hard to reproduce because some criteria are not strictly hierarchical or exclusive. Numerical cluster analysis was used as an objective classification method. This method offers reproducible, quantitative results and full hierarchical distinction between the classes. Qualitative information, however, is not accounted for in the objective numerical approach and may thus be viewed as less complete when representing local landscape details. Both classifications represent major vegetation characteristics consisting of a complex mosaic of forests (coniferous, mixed coniferousdeciduous, deciduous, and swamps), savannas (oak and pine), and prairies. The objective classification indicates that savannas cover two times more (40%) and prairies six times less area (2%) compared with the subjective classification (savanna, 20%; prairie, 12%). We address the applications of these classifications to current and potential restoration projects, including eastern hemlock (Tsuga canadensis), wetland/riparian, savanna, and prairie ecosystems.
Interstitial lung disease in an adult with Fanconi anemia: Clues to the pathogenesis

We have studied a 38-year-old man with a prior diagnosis of Holt-Oram syndrome, who presented with diabetes mellitus. He had recently taken prednisone for idiopathic interstitial lung disease and trimethoprim-sulfamethoxazole for sinusitis. Thrombocytopenia progressed to pancytopenia. The patient had skeletal, cardiac, renal, cutaneous, endocrine, hepatic, neurologic, and hematologic manifestations of Fanconi anemia (FA). Chest radiographs showed increased interstitial markings at age 25, dyspnea began in his late 20s, and he stopped smoking at age 32. At age 38, computerized tomography showed bilateral upper lobe fibrosis, lower lobe honeycombing, and bronchiectasis. Pulmonary function tests, compromised at age 29, showed a moderately severe obstructive and restrictive pattern by age 38. Serum alpha-1 antitrypsin level was 224 (normal 85-213) mg/dL and PI phenotype was M1. Karyotype was 46,XY with a marked increase in chromosome aberrations induced in vitro by diepoxybutane. The early onset and degree of pulmonary disease in this patient cannot be fully explained by environmental or known genetic causes. The International Fanconi Anemia Registry (IFAR) contains no example of a similar pulmonary presentation. Gene-environment (ecogenetic) interactions in FA seem evident in the final phenotype. The pathogenic mechanism of lung involvement in FA may relate to oxidative injury and cytokine anomalies.
Standards--Why bother?

Increased acceptance of several new oceanographic flow sensors such as Coastal Ocean Dynamics Applications Radar (CODAR), Doppler backscatter profilers, the InterOcean S-4, the Smart ACM and others have renewed our interest in flow measurement techniques and methods of data interpretation. Several areas exist in which the oceanographic current meter community might begin to establish guidelines or "standard". Specific problem areas are discussed, and some specific solutions are recommended.
Hypoxia mediated binding of misonidazole in non-malignant tissue

Binding of 3H-misonidazole in hypoxic nonmalignant tissue was investigated in the gerbil stroke model. Cerebral infarcts were produced in male Mongolian gerbils by ligating the right common carotid artery and the severity of the lesions was quantified by scoring the animals' symptoms. The uptake of [H-3]misonidazole in the right cerebral hemisphere and the ratios of right:left hemispheral uptake correlated positively with the severity of the stroke when measured 6 to 10 hours after carotid ligation. Autoradiographs of the gerbil brains with severe infarcts showed heavy label, which was uniformly distributed, on the affected side. We conclude that the gerbil stroke model is useful for studying hypoxia in vivo. There is variability between animals that closely correlates with stroke index, but more importantly the hypoxia may be more homogeneous over regions of the brain within one animal. A reliable model of homogeneous induced hypoxia in vivo will be useful for evaluating radiolabeled drugs which may be used for quantitation of hypoxia in tumors by nuclear imaging.
The Iterative Multi-Region Algorithm Using a Hybrid Finite Difference Frequency Domain and Method of Moment Techniques

This paper presents a hybrid technique, which combines the desirable features of two different numerical methods, finite difference frequency domain (FDFD) and the method of moments (MoM), to analyze large-scale electromagnetic problems. This is done by dividing the computational domain into smaller sub-regions and solving each sub-region using the appropriate numerical method. Once each sub-region is analyzed, independently, an iterative approach takes place to combine the sub-region solutions to obtain a solution for the complete domain. As a result, a considerable reduction in the computation time and required computer memory is achieved.
Spatial outlier detection in heterogeneous neighborhoods

Spatial outlier detection approaches identify outliers by first defining a spatial neighborhood. However, existing approaches suffer from two issues: (1) they primarily consider autocorrelation alone in forming the neighborhood, but ignore heterogeneity among spatial objects. (2) they do not consider interrelationships among the attributes for identifying how distinct the object is with respect to its neighbors, but consider them independently (either single or multiple). As a result, one may not identify truly unusual spatial objects and may also end up with frivolous outliers. In this paper, we revisit the computation of the spatial neighborhood and propose an approach to address the above two issues. We begin our approach with identifying a spatially related neighborhood, capturing autocorrelation. We then consider interrelationships between attributes and multiple, multilevel distributions within these attributes, thus considering autocorrelation and heterogeneity in various forms. Subsequently, we identify outliers in these neighborhoods. Our experimental results in various datasets (North Carolina SIDS data, New Mexico Leukemia data, etc.) indicate that our approach indeed correctly identifies outliers in heterogeneous neighborhoods.
A comparison of techniques for estimating IDF values to generate lexical signatures for the web

For bounded datasets such as the TREC Web Track the computation of term frequency (TF) and inverse document frequency (IDF) is not difficult. However, since IDF cannot be directly calculated for the entire web, it must be estimated. We see a need to estimate accurate IDF values to generate TF-IDF based lexical signatures (LSs) of web pages. Future applications for generating such LSs require a real time IDF computation. Therefore we conducted a comparison study of different methods to estimate IDF values of web pages. Our objective is to investigate how accurate these estimation methods are compared to the a baseline. We use the Google N-grams as our baseline and compare it against two IDF estimation techniques which are based on: 1) a "local universe" consisting of textual content and the according document frequencies from copies of URLs from the Internet Archive and 2) "screen scraping", a technique to query the Google web interface for document frequencies. We found a term overlap of 70 to 80% between the results of the two methods and the baseline. We further discovered a great agreement in rank correlation of TF-IDF ranked terms between our methods. Kendall τ is approximately 0.8 and the M-Score (penalizing discordances in higher ranks) is even higher, it peaks at well above 0.9. These preliminary results lead us to the conclusion that both methods are appropriate for creating accurate IDF values for web pages.
A moment generating algorithm for solution of MTL equations with frequency dependent loss

This paper presents a general method for evaluating the moments of eigenvalue and eigenvector matrices for use in solving multiconductor transmission line (MTL) problems with frequency dependent losses. It is appropriate for use with asymptotic waveform evaluation (AWE) and multipoint Pade methods.
A 14th Way to Look at a Correlation Coefficient: Correlation as the Proportion of Matches

Abstract An interpretation of the correlation coefficient is presented that describes the coefficient in terms of the proportion of matches in an idealized data set. This characteristic is then expressed as the result of the definition of the Pearson product-moment correlation. An expression is derived to relate the correlation coefficient to the proportion of times a second variable falls within a set range of the first. Both a simulation and a real data example are presented to show how this would be reflected in data.
Bullying among Young Children: Strategies for Prevention.

Bullying is an increasing problem within childcare facilities, preschool programs, and public schools. As a result, many districts are instituting anti-bullying intervention programs. This article defines bullying and explains the direct and indirect forms it can take. First, it examines research on bullying during the beginning years of school. Next, it explains how relational aggression occurs and the importance of positive peer support systems within their schools. The article concludes by examining the effects of consistent anti-bullying initiatives (e.g. conflict resolution strategies, daily check-ins, journals, and peacemaking activities) that address bullying behaviors among young children. Through consistent and clear interventions, students can build positive peer relationships that promote a safe and healthy school climate and culture.
In situ signatures of residual plasmaspheric plumes: Observations and simulation

We compare in situ observations of the Los Alamos National Laboratory (LANL) Magnetospheric Plasma Analyzers with output of a dynamic, plasmapause test particle (PTP) simulation for the moderately disturbed interval 18–20 January 2000. In the model, weakly enhanced convection on 18 January creates a narrow drainage plume (plume A) that wraps completely around the main torus. Moderate convection on 19 January triggers significant plasmaspheric erosion, forming a second plume (B) that coexists with the narrow, wrapped, residual plume A. We fly three virtual LANL satellites through the simulation domain. The observations are globally consistent with the PTP simulation; LANL data contain several intervals of plume plasma in the model's predicted magnetic local time (MLT) sector. The modeled durations of plume sector transits are in good agreement with the LANL data. On a subglobal scale, the MLT widths and timings of the simulated plumes do not precisely agree with observations. However, several observation intervals exhibit good morphological agreement with virtual spacecraft signatures of two distinct, coexisting plumes (A and B). The fine-scale structure in the PTP model arises from the merging of residual plume A with the newer plume B. Plume merging is one theoretical means of generating fine structure in the plasmasphere: during multiple cycles of erosion and recovery, successive layers of wrapped, residual plumes can merge with newer plumes, creating layers of filamentary density structure. The model-data comparisons suggest that the plasmaspheric density distribution may preserve some memory of prior epochs of erosion and recovery.
Advancing the Battle Against Acute Ischemic Syndromes: A Focus on the GP IIb‐IIIa Inhibitors

Platelet aggregation and thrombus formation, resulting from disruption of a coronary artery plaque, play a critical role in the pathology of acute coronary syndromes. Currently, aspirin and heparin are administered to decrease platelet aggregation. The discovery of the platelet integrin receptor alpha(IIb)beta3, also known as the platelet glycoprotein (GP) IIb-IIIa receptor, is a breakthrough in antiplatelet therapy. The GP IIb-IIIa receptor is responsible for the crucial binding of fibrinogen to platelets, leading to cross-links between platelets and further platelet aggregation. Since the introduction of abciximab, the first GP IIb-IIIa-receptor antagonist, several other nonantibody agents have been studied for use in percutaneous transluminal coronary angioplasty and also in stent placement, treatment of unstable angina, and myocardial infarction.
Feminist Scholarship and the Study of Relationships

This article explores intersections between research on personal and social relationships, on the one hand, and feminist study, on the other. Focused on the means and effects of social constructions of gender, feminist enquiry clarifies how gender affects interaction processes and participants' and researchers' interpretations of them. This article outlines key facets of feminist scholarship and shows how they complement, extend and revise research on relationships.
Rollout strategy for Hidden Markov Model (HMM)-based dynamic sensor scheduling

In this paper, a hidden Markov model (HMM)-based dynamic sensor scheduling problem is formulated, and solved using rollout concepts to overcome the computational intractability of the dynamic programming (DP) recursion. The problem considered here involves dynamically sequencing a set of sensors to minimize the sum of sensor cost and the HMM state estimation error cost. The surveillance task is modeled as a single HMM with multiple emission matrices corresponding to each of the sensors. The rollout information gain (RIG) algorithm proposed herein employs the information gain (IG) heuristic as the base algorithm. The RIG algorithm is illustrated on an intelligence, surveillance, and reconnaissance (ISR) scenario of a village for the presence of weapons and terrorists/refugees. Extension of the RIG strategy to monitor multiple HMMs involves combining the information gain heuristic with the auction algorithm that computes the K -best assignments at each decision epoch of rollout.
Endogenous retroviruses of the chicken genome

We analyzed the chicken (Gallus gallus) genome sequence to search for previously uncharacterized endogenous retrovirus (ERV) sequences using ab initio and combined evidence approaches. We discovered 11 novel families of ERVs that occupy more than 21 million base pairs, approximately 2%, of the chicken genome. These novel families include a number of recently active full-length elements possessing identical long terminal repeats (LTRs) as well as intact gag and pol open reading frames. The abundance and diversity of chicken ERVs we discovered underscore the utility of an approach that combines multiple methods for the identification of interspersed repeats in vertebrate genomes.
Optical properties of thick metal nanohole arrays fabricated by electron-beam and nanosphere lithography

Optically thick metallic nanohole structures were fabricated using two different methods ― electron-beam and nanosphere lithography. The nanosphere lithography technique was based on self-assembling of polystyrene or silica nanospheres (0.560―1.25 μm in diameter) followed by the deposition of a silver film. The holes size and periodicity of the patterns as well as optical properties (transmission and reflection in the Visible―NIR) of the structures were investigated. The extraordinary optical transmission (EOT) was studied experimentally in both structures and it was found to be dependent on the geometrical parameters (holes shape, diameter and periodicity of structures). As the samples were made for long range order, the effect of the defects like missing holes, change of periodicity or variation of the holes shape, were also studied. The experimental results, especially the position of the SPR band in the different nanohole structures, were compared with those found by simulation carried out with 3D FDTD (finite difference time domain).
Poster: rethinking raid for SSD based HPC systems

The emerging Solid State Drives (SSDs) have changed the landscape of storage systems and have the potential to be widely deployed in computing systems including HPC systems. However, the cost and the capacity of SSDs have often been cited as the primary barrier to SSD deployment. In this study, we revisit the RAID design and propose a new hybrid-RAID (HRAID) architecture to explore the low-cost and high-capacity merits of HDDs and the low-latency and high-bandwidth merits of SSDs. The initial results show the promise of the proposed HRAID architecture in terms of the reliability, performance, cost, and capacity.
Autism Intervention Research: From the Reviews to Implications for Practice

Early intervention for children with autism is currently a focus in both the research literature, popular literature, and in practice. A number of reviews exist that examine studies of comprehensive interventions and targeted interventions, including those that examine environmental variables, participant and interventionist variables, methods of instruction, and nonresponders. All seek an understanding of the best interventions to ameliorate symptoms, identify treatment by individual characteristics, improve the quality of life, and demonstrate positive short- and long-term outcomes for young children with autism. There is little question that early intervention is beneficial, particularly for improving functional skills and developmental skills, improving core-deficits such as play, and reducing maladaptive behaviors and symptoms. General evidenced-based guidelines for treatment have been formulated (National Research Council, 2001) but few well-designed (randomized control) studies exist. Indeed, methodologically the studies are incomparable, the variability in the population and the samples are overwhelming, and the results are complex and difficult to interpret from both a research and practical standpoint. This chapter aims to help practitioners better understand how to use evidenced-based practice by synthesizing literature reviews on early intervention, presenting an example of an early intervention program that uses an evidenced-based yet clinically eclectic approach to treatment, and discussing implications for further intervention studies and treatment programs.
Oscillators and Mixers

This chapter contains sections titled: Gunn Oscillators IMPATT Diodes Transistor Oscillators Three-Port Description of a Transistor Oscillator Circuits Oscillator Design Mixers Mixer Noise Figure Balanced Mixers Other Types of Mixers Mixer Analysis Using Harmonic Balancing This chapter contains sections titled: Problems References
Growth and Electrical Properties of Free-Standing Zinc Oxide Nanomembranes

We report the synthesis of free-standing two-dimensional semiconductor zinc oxide (ZnO) nanomembranes (NMs) using a bottom-up approach, i.e., nanomembranes grown from the faceted sidewalls of horizontally oriented ZnO nanowires (NWs). The ZnO NMs were synthesized on r-plane sapphire substrates utilizing high purity ZnO powder and graphite mixture and oxygen as source materials and argon (Ar) as carrier gas. Material characterization confirms that the horizontally oriented ZnO NWs were guided grown via a vapor–liquid–solid growth mechanism using gold as catalyst. The ZnO NMs were nucleated from the coated gold catalysts on the sidewalls of NWs. The electrical properties of the ZnO NMs were characterized based on a back-gate field effect transistor. The estimated carrier mobility of the ZnO NM is ∼150 cm2 V–1 s–1. The as-grown free-standing NMs can serve as the fundamental building blocks for a variety of applications in electronics and optoelectronics as well as sensing technologies. The unique bottom-up s...
An algorithm for fast calculation of short circuit forces in high current busbars of electric arc furnace transformers based on method of images

Abstract This paper proposes an algorithm for the calculation of short circuit forces on the high current busbars of electric arc furnace (EAF) transformers based on the method of images using an analytical solution for the electromagnetic force between two adjacent current carrying rectangular conductor. The theory of images is used to account for the impact of the tank walls on the short circuit forces on the busbars. The proposed method uses an iterative algorithm and increases the number of image layers to achieve the desired accuracy. A 30 MVA EAF transformer is investigated as a case study and the results are compared to 2D finite element analysis (FEA). ANSYS software is used for the FEA. The proposed algorithm converges very fast, so that only in its first iteration, the convergence error is less than 0.2%. The comparisons show that the short circuit force calculations using the proposed method, conform to the 2D FEA results. However, the short-circuit calculation time using the proposed method is about 20 times faster than the 2D FEA with the same relative error. Therefore it can be used as a faster alternative for the FEA. The proposed method is characterized by fast convergence, simple calculations and high precision.
Adipose tissue cholesterol storage: the effect of essential fatty acid deficiency.

SummaryEssential fatty acid deficiency was induced in one group of rats by feeding a fat-free diet, and in another group by supplying hydrogenated coconut oil. All deficient animals had significantly reduced weight gain and tended to have decreased epididymal fat cell size compared to controls. Rats in the fat-free group had significantly more adipocyte free cholesterol than control animals, but no significant alteration in stored free sterol occurred in rats made essential fatty acid deficient with hydrogenated coconut oil. Between experimental essential fatty acid deficient groups, the fat-free group had greater quantities of adipocyte free, and hence, total cholesterol. No alterations in ester content due to essential fatty acid deficiency could be demonstrated, although the percentage of total cholesterol as esters decreased significantly in both experimental groups. It is suggested that adipose tissue responds differently than other peripheral tissues to essential fatty acid deficiency.
Effects of Hypophysectomy, ACTH, Cortisone and Estradiol on the β-Glucuronidase Activity of Adrenal Gland in the Rat.

SummaryThe effects of hypophysectomy and ACTH, cortisone acetate and estradiol benzoate administration on the β-glucuroni-dase activity of the adrenal gland in the rat have been investigated. ACTH, cortisone and estradiol, while producing their characteristic effects on adrenal and body weights, failed to modify the β-glucuronidase concentrations in the gland. Hypophysectomy, on the other hand, effected a statistically significant increase in adrenal β-glucuronidase activity.
FEM-Simulation von Sandwich-Elementen: mit Wabenkern für die Karosserie

Wabenformige Sandwich-Strukturen in Leichtbauweise werden in der Automobilindustrie vermehrt im Bereich von Hutablagen bis zur Ladeflache angewandt. Eine unzahlige Vielfalt verschiedener Losungen, abhangig von der Wahl der Kerngeometrie und des Werkstoffs, kann fur diese Segmente eingesetzt werden. In der Entwicklungsphase wird ein effizientes Vorhersage-Werkzeug benotigt - Rieter entwickelte hierfur ein auf einer asymptotischen Multiskalen-Methode basierendes mathematisches Modell.
Proteomic Profiling Identifies PTK2/FAK as a Driver of Radioresistance in HPV-negative Head and Neck Cancer

Purpose: Head and neck squamous cell carcinoma (HNSCC) is commonly treated with radiotherapy, and local failure after treatment remains the major cause of disease-related mortality. To date human papillomavirus (HPV) is the only known clinically validated, targetable biomarkers of response to radiation in HNSCC. Experimental Design: We performed proteomic and transcriptomic analysis of targetable biomarkers of radioresistance in HPV-negative HNSCC cell lines in vitro, and tested whether pharmacologic blockade of candidate biomarkers sensitized cells to radiotherapy. Candidate biomarkers were then investigated in several independent cohorts of patients with HNSCC. Results: Increased expression of several targets was associated with radioresistance, including FGFR, ERK1, EGFR, and focal adhesion kinase (FAK), also known as PTK2. Chemical inhibition of PTK2/FAK, but not FGFR, led to significant radiosensitization with increased G2/M arrest and potentiated DNA damage. PTK2/FAK overexpression was associated with gene amplification in HPV-negative HNSCC cell lines and clinical tumors. In two independent cohorts of patients with locally advanced HPV-negative HNSCC, PTK2/FAK amplification was highly associated with poorer disease-free survival (DFS) (P=0.012 and P=0.034). PTK2/FAK mRNA expression was also associated with worse DFS (P=0.03). Moreover, both PTK2/FAK mRNA (P=0.021) and copy number (P=0.063) were associated with DFS in the Head and Neck Cancer subgroup of The Cancer Genome Atlas. Conclusion: Proteomic analysis identified PTK2/FAK overexpression is a biomarker of radioresistance in locally advanced HNSCC, and PTK2/FAK inhibition radiosensitized HNSCC cells. Combinations of PTK2/FAK inhibition with radiotherapy merit further evaluation as a therapeutic strategy for improving local control in HPV-negative HNSCC.
Analysis on age and working years among 111 cases of suspected occupation disease in Haidian district,Beijing

Objective To understand occurrence of suspected occupation diseases from investigation on occupation health status of key industry in Haidian District,analyze the existing problems and provide some suggestions.Methods Using household general survey,the occupation health status survey of key industries in Haidian district was carried out,we conducted physical examination among workers exposing occupational hazards and analyzed the results.Results Among 5066 workers,the detection rate of suspected occupation disease was 2.2%,including 96 cases of suspected benzene poisoning and 15 cases of other suspected occupation diseases; The lowest average age and shortest working years were found among cases of suspected benzene poisoning in small and private enterprises,( P 0.05); No statistical difference was observed among different industry in average age and working years of suspected occupation diseases sufferers.Conclusion The most serious occupational hazard should be benzene exposure,and some small and private enterprises should be supervised more strictly.
Teaching a "Critical Accessibility Case Study": Developing Disability Studies Curricula for the Technical Communication Classroom.

As technical communication (TC) instructors, it is vital that we continue reimagining our curricula as the field itself is continually reimagined in light of new technologies, genres, workplace pra...
Photoaffinity labeling of calmodulin byphenothiazine antipsychotics.

Previous studies have shown that the binding of radiolabeled phenothiazine antipsychotics to calmodulin can be reversed by removing calcium or by dialyzing against an excess of nonradiolabeled phenothiazine. The present studies show that the binding of [3H]-chlorpromazine or [3H]trifiuoperazine to calmodulin can be made irreversible by irradiating the samples with UV light. Like the reversible binding of these agents to calmodulin, the irreversible binding was enhanced by calcium. This calcium-dependent binding was saturable, with approximately one binding site per molecule of calmodulin; one-half maximal binding occurred at a chlorpromazine concentration of approximately 10 µM and at a trifluoperazine concentration of 5 µM. The irreversible binding of chlorpromazine to calmodulin probably involves the formation of a covalent bond, since extensive dialysis and treatment with denaturing agents failed to displace the bound chlorpromazine from calmodulin. Chlorpromazine displayed little or no irreversible calcium-dependent binding to bovine serum albumin, trypsin, histone, or hemoglobin. Nonphenothiazine antipsychotics, such as penfluridol and haloperidol, and a number of other centrally active drugs, such as diazepam, apomorphine, and dopamine, showed little or no irreversible binding to calmodulin. However, the nonphenothiazine antipsychotics did block the irreversible binding of chlorpromazine and trifluoperazine to calmodulin. Psychotropic drugs with little antipsychotic activity did not prevent the irreversible binding of the phenothiazines. UV-irradiated samples of calmodulin and chlorpromazine or trifluoperazine failed to activate phosphodiesterase even after extensive dialysis, indicating that the irreversible binding of the phenothiazines to calmodulin results in an irreversible inhibition of the biological activity of calmodulin. These results suggest that the irreversible binding of antipsychotics to calmodulin may account for some of the long-term actions of these drugs and may provide a means with which to study the location and turnover of this calcium-binding protein.
SU-F-T-130: [18F]-FDG Uptake Dose Response in Lung Correlates Linearly with Proton Therapy Dose

Purpose: Analysis of clinical outcomes in lung cancer patients treated with protons using 18F-FDG uptake in lung as a measure of dose response. Methods: A test case lung cancer patient was selected in an unbiased way. The test patient's treatment planning and post treatment positron emission tomography (PET) were collected from picture archiving and communication system at the UT M.D. Anderson Cancer Center. Average computerized tomography scan was registered with post PET/CT through both rigid and deformable registrations for selected region of interest (ROI) via VelocityAI imaging informatics software. For the voxels in the ROI, a system that extracts the Standard Uptake Value (SUV) from PET was developed, and the corresponding relative biological effectiveness (RBE) weighted (both variable and constant) dose was computed using the Monte Carlo (MC) methods. The treatment planning system (TPS) dose was also obtained. Using histogram analysis, the voxel average normalized SUV vs. 3 different doses was obtained and linear regression fit was performed. Results: From the registration process, there were some regions that showed significant artifacts near the diaphragm and heart region, which yielded poor r-squared values when the linear regression fit was performed on normalized SUV vs. dose. Excluding these values, TPS fit yielded mean r-squared value of 0.79 (range 0.61–0.95), constant RBE fit yielded 0.79 (range 0.52–0.94), and variable RBE fit yielded 0.80 (range 0.52–0.94). Conclusion: A system that extracts SUV from PET to correlate between normalized SUV and various dose calculations was developed. A linear relation between normalized SUV and all three different doses was found.
Antigenic activity of human urothelial tissue.

AbstractPartially purified extracts from 71 human urothelial tumors and from 75 human urothelial non-tumor tissues were used as competing antigens in competition radioimmunoassay in an effort to detect the presence of 1 of thestructural components of type C-ribonucleic acid viruses, the p30 core protein. Testing of the tissue extracts was carried out by homologous and heterologous assay systems using 125I-labeled murine (Friend) and feline (Rickard) p30 antigens and anti-feline and anti-murine p30 antisera. The homologous assays were designed to detect the presenceofp30 antigens in the human tissue extracts having similar characteristics to the p30 antigens of either the feline or murine type C viruses. The heterologous assay system was designed to detect interspecies antigenic determinants common tomurine and feline viruses and also primate viruses. A competing antigen present in 28 per cent of the tissue extracts assayed demonstrated an antigenic protein that competed with the viral p30 protein used in ...
Looking toward the future: an individualized approach to allogeneic transplantation

Personalized medicine will become increasingly integrated into allogeneic transplantation over the coming decade. Advances will include individualized evaluation and preemptive therapy for recurrent malignancy, as well as an evolving approach to GVHD prediction, diagnosis and treatment. Measures of minimal residual disease will identify patients at increased risk of relapse and allow therapy to be modified accordingly. Similarly, GVHD biomarkers will allow risk-stratification early post-transplant, facilitating rational preemptive therapy with novel immunotherapeutics and immune modifying reagents for patients at greatest risk. Several examples for each of these approaches will be discussed, as well as their integration into a potential treatment algorithm.
STAT3 as a mediator of neuroendocrine-induced invasion in ovarian cancer

AACR Annual Meeting-- Apr 14-18, 2007; Los Angeles, CA 2148 Objectives : Chronic stress is associated with cancer growth and progression, but the underlying mechanisms of this association are incompletely understood. We examined the role of STAT3, a transcription factor affecting many oncogenic pathways, in mediating invasion and metastasis pathways induced by the stress-associated hormones norepinephrine (NE), epinephrine (Epi), and isoproterenol (Iso). Methods : In vitro, the epithelial ovarian cancer cell lines SKOV3 and EG were exposed to increasing concentrations of NE, Epi, or Iso, with and without beta-blockers (propanolol), alpha1- or alpha-2 blockers (prazosin or yohimbine). STAT3 activation, localization, and DNA binding were measured by Western blot, immunohistochemistry, and the Electrophoretic Mobility Shift Assay (EMSA). MMP-2 and MMP-9 levels were measured by ELISA. In vivo, orthotopic ovarian tumors were examined for patterns of metastasis (by inspection) and MMP-2 and MMP-9 expression (by immunohistochemistry) in mice subjected to chronic beta agonists, with and without liposomal STAT3-specific siRNA. Results : NE, Epi and Iso induce phosphorylation of STAT3, with subsequent translocation to the nucleus and DNA binding, in a dose-dependent fashion in both SKOV3 and EG cell lines. STAT3 phosphorylation was inhibited by propanolol and by KT5720 (PKA inhibitor); but not by prazocin, yohimbime, or anti-IL-6 antibody. Cells stimulated with Iso had increased MMP-2 (by 2.4-fold) and MMP-9 (1.9-fold) production, but this increase was abrogated by STAT3 inhibition with anti-STAT3 siRNA. In mice stressed with daily Iso, tumors were significantly more invasive, and had increased MMP-2 and MMP-9 expression. However, downregulation of STAT3 with liposomal siRNA completely abrogated the increased invasiveness and MMP-2 and -9 induction by Iso. Conclusions : Stress hormones acting through beta-adrenergic receptors induce STAT3 activation, with subsequent transport to the nucleus and DNA binding. Through STAT3, these hormones increase MMP-2 and MMP-9 expression, and tumor invasiveness. This pathway may play an important role in malignant progression, with particular importance in conditions of chronic stress.
THE MIOCENE TIHAMA ASIR OPHIOLITE AND ITS BEARING ON THE OPENING OF THE RED SEA

In early Miocene time (ca. 2. Ma ago), dike swarms, layered gabbros, granophyres, and basalts of the Tihama Asir ophiolite in S.W. Saudi Arabia were emplaced during the initial stages of Red Sea rifting and separation of the African and Arabian plates. As rifting began, dikes invaded Paleozoic and Mesozoic sedimentary and Precambrian metamorphic rocks of the Arabian plate along a northwesterly trend paralleling the axial trough of the Red Sea. With increased separation along the rift edge, new crust was accreted to the continental margin. This crust consisted of a 4 km wide zone of subparallel dikes having chilled margins against one another and lacking screens of older continental rock. This dike complex is analogous to the sheeted dike swarms described from the Cyprus, Oman, and Newfoundland ophiolites. Layered gabbros and granophyric intrusions within the dike swarm are products of magmatic differentiation developed during the initial stages of rifting. The differentiation trends indicate that the parent magma was tholeiitic and evolved by crystal fractionation in much the same manner as lavas at Thingmuli Volcano, Iceland. Late Miocene tilting of the sedimentary rocks and dike swarm toward the Red Sea axis and later erosion have exposed the continental-oceanic crust boundary along a narrow zone. The continental Baid Formation (19 Ma) rests unconformably on the Tihama Asir ophiolite.
Arylation of hydrocarbons enabled by organosilicon reagents and weakly coordinating anions

Over the past 80 years, phenyl cation intermediates have been implicated in a variety of C–H arylation reactions. Although these examples have inspired several theoretical and mechanistic studies, aryl cation equivalents have received limited attention in organic methodology. Their high-energy, promiscuous reactivity profiles have hampered applications in selective intermolecular processes. We report a reaction design that overcomes these challenges. Specifically, we found that β-silicon–stabilized aryl cation equivalents, generated via silylium-mediated fluoride activation, undergo insertion into sp3 and sp2 C–H bonds. This reaction manifold provides a framework for the catalytic arylation of hydrocarbons, including simple alkanes such as methane. This process uses low loadings of Earth-abundant initiators (1 to 5 mole percent) and occurs under mild conditions (30° to 100°C).
Psychotomimetic and Cognitive Effects of Δ9-Tetrahydrocannabinol in Laboratory Settings

Abstract There exists a rich literature of human laboratory studies (HLS) involving cannabis and cannabinoids dating back to the 1970s, reporting on an array of outcomes ( Sherif, Radhakrishnan, D'Souza, & Ranganathan, 2016 ). Perhaps most relevant to psychotic disorders, a significant portion of this literature focuses specifically on psychotomimetic and cognitive effects of Δ9-tetrahydrocannabinol (THC). A range of transient dose-dependent psychotomimetic and deleterious cognitive effects of THC have been reported in healthy humans, as well as in those with cannabis use disorder, increased risk of psychosis, and schizophrenia. Polymorphisms in the COMT, DAT1, and ATK1 genes, as well as drugs such as haloperidol, iomazenil, and cannabidiol, have been reported to influence these effects. Psychophysiological correlates of the clinical effects have been explored using functional magnetic resonance imaging, positron emission tomography, single photon emission computerized tomography, and electroencephalography (EEG). Of greatest promise perhaps is an EEG measure of neural noise that may have wider clinical implications as a biomarker of psychosis. With unique methodological strengths (as well as limitations), HLS provide a valuable contribution to the wider effort to probe the complex connection between cannabis and schizophrenia.
Application of the Aquifer Impact Model to support decisions at a CO2 sequestration site

The National Risk Assessment Partnership (NRAP) has developed a suite of tools to assess and manage risk at CO2 sequestration sites. The NRAP tool suite includes the Aquifer Impact Model (AIM), which evaluates the potential for groundwater impacts from leaks of CO2 and brine through abandoned wellbores. There are two aquifer reduced-order models (ROMs) included with the AIM tool, a confined alluvium aquifer, and an unconfined carbonate aquifer. The models accept aquifer parameters as a range of variable inputs so they may have broad applicability. The generic aquifer models may be used at the early stages of site selection, when site-specific data is not available. Guidelines have been developed for determining when the generic ROMs might be applicable to a new site. This paper considers the application of the AIM to predicting the impact of CO2 or brine leakage were it to occur at the Illinois Basin Decatur Project (IBDP). Results of the model sensitivity analysis can help guide characterization efforts; the hydraulic parameters and leakage source term magnitude are more sensitive than clay fraction or cation exchange capacity. Sand permeability was the only hydraulic parameter measured at the IBDP site. More information on the other hydraulic parameters could reduce uncertainty in risk estimates. Some non-adjustable parameters are significantly different for the ROM than for the observations at the IBDP site. The generic ROMs could be made more useful to a wider range of sites if the initial conditions and no-impact threshold values were adjustable parameters. © 2017 Society of Chemical Industry and John Wiley & Sons, Ltd.
Interface characterization of atomic layer deposited high-k on non-polar GaN

The interface properties between dielectrics and semiconductors are crucial for electronic devices. In this work, we report the electrical characterization of the interface properties between atomic layer deposited Al2O3 and HfO2 on non-polar a-plane ( 11 2 ¯ 0 ) and m-plane ( 1 1 ¯ 00 ) GaN grown by hybrid vapor phase epitaxy. A metal oxide semiconductor capacitor (MOSCAP) structure was used to evaluate the interface properties. The impact of annealing on the interface properties was also investigated. The border trap in the oxide, characterized by the capacitance-voltage (C-V) hysteresis loop, was low. The interface state density (Dit), extracted using the ac conductance method, is in the range of 0.5 × 1012/cm2 eV to 7.5 × 1011/cm2 eV within an energy range from 0.2 eV to 0.5 eV below the conduction band minimum. The m-plane GaN MOSCAPs exhibited better interface properties than the a-plane GaN MOSCAPs after annealing. Without annealing, Al2O3 dielectrics had higher border trap density and interface st...
Events and Accidents

This chapter recalls the most significant events in the Catalan self-reflective story. The death of Martin I. The Civil War and the War of Succession. Martin the Humane without an heir; Isabella and Ferdinand; Phillip V and the bombing of Barcelona. 1714; October 2017.
Childhood Self-Control and Adolescent Obesity: Evidence from Longitudinal Data on a National Cohort.

Abstract Background: Whether self-control at school entry and changes in self-control in the early school years are predictive of BMI change and obesity onset over the next 8 years using longitudinal data on a nationally representative sample of US children. Methods: Data from the Early Childhood Longitudinal Study–Kindergarten Class 1998 were analyzed. The analysis sample included 7060 children with data from kindergarten (mean age = 6 years) until eighth grade (mean age = 14 years). Self-control was assessed using teacher-reported scales. Child BMI and obese status (BMI ≥95th percentile for age and gender) were computed from height and weight measurements. Weighted linear and logistic regression models were estimated, adjusting for child's cognitive ability and a rich set of child and family covariates. Results: High self-control in kindergarten was associated with lesser BMI increase (p < 0.05) and 43% lower odds (adjusted OR [AOR] = 0.57, 95% confidence interval [CI]: 0.38–0.86) of new onset obesity o...
Contingencias de reforzamiento y momento conductual: Investigaci6n y aplicaciones

A discriminative operant is defined by the combination of an antecedent stimulus, a response, and a reinforcer. The response-reinforcer contingency determines the rate of the response, and the stimulus-reinforcer contingency determined the resis­tance to change of that response rate. The product of response rate and its resis­tance to change is characterized metaphorically as behavioral momentum. This article describes sorne basic research on the determiners of momentum and discus­ses some applications of momentum analyses in clinical and educational settings. Some more speculative applications to business and industry, international war, and problems of sustainable development are also considered.