The BRAIN Initiative.

What is the first association that comes to mind when you hear “fiber optics”? Connecting one side of the Atlantic Ocean to the other, or high-definition television? For sure, it would not be manipulation of neuronal firing … unless you are a neuroscientist. While neuroscience has relied on optics to power discovery and advancement from the beginning of time, brain imaging remains an exotic application in mainstream optics and photonics. The Presidential BRAIN Initiative that launched in April of 2013 targets this disconnect by encouraging “hard core” technology experts to step up to the neuroscience quest. The goal of the Initiative is to develop new technologies driven by the needs of basic and translational neuroscience—easy to say, but difficult to do. The first challenge for the technology expert is to understand the needs of the endpoint application; for the neuroscientist, the challenge is to keep up with the rapidly developing technology and recognize its strengths and limitations. Generally speaking, brain tissue is an unfriendly environment for optics. Light is scattered by microscopic structures with different refractive indices and absorbed by natural chromophores. Red blood cells fly through capillaries, scattering and absorbing light along the way. The brain moves (slightly but noticeably on a microscopic scale) with respiration and heartbeat beyond what can be corrected for by rigid body registration. Furthermore, the duration of an action potential is only 1–2 ms, which imposes stringent constraints on the acquisition speed required for measurements of brain activity. In addition, brain tissue is sensitive to heating and photodynamic damage, placing limits on photon flux. Despite these limitations, consider this: arguably the most significant breakthroughs in neuroscience have been powered by advancements in optical technology, from the discovery of synaptic junctions by the father of modern neuroscience Ramon Y. Cajal in the 1880s, to contemporary advances in cell- and system-level neuroscience through utilization of two-photon microscopy, optogenetics, and superresolution microscopy. The BRAIN Initiative seeks to accelerate these efforts by scaling up the development of existing tools and encouraging exploration of new technological concepts to dramatically advance our understanding of how the brain works. Our first issue of Neurophotonics is published on the upswing of the initiative with a dedicated special section featuring a spectrum of papers on optical tools for measurement and manipulation of the brain’s neuronal, metabolic, and hemodynamic activity. This wide scope reflects the breadth of the arena and underscores collaborative opportunities for optics and photonics for targeted technology development rooted in the forefront of neuroscience research. In short, advances in the brain sciences require the attention of strong technology experts. The BRAIN Initiative has already succeeded in increasing the visibility of this seemingly exotic application within the optical community. The next step is to provide a path for a long-term multidisciplinary relationship enabling comprehensive technological developments emerging from proof of concept studies and leading to broad adoption by basic and clinical neuroscientists. Somewhere along this path, the brain application will become a little less exotic. However, the excitement will only grow as application-driven technology and technology-powered neuroscience evolve in a continual dialog.