cssi/SciSciGPT-SciSciNet huggingface dataset:
Dichotic listening performance in young adults using low-pass filtered speech.

Background Assessment of interaural asymmetry (IA) on dichotic listening tests becomes challenging when accuracy on one or both ears are at ceiling. Cognitive task demands are often increased to avoid this situation, raising the possibility that non-auditory-specific processes will further influence IA estimation. Purpose To investigate the utility of low-pass filtered dichotic speech stimuli (dichotic filtered words [DFWs]) as a potential auditory-specific technique for increasing task difficulty in the dichotic listening paradigm. Research design A prospective experimental study investigating differences in IA observed for a group of young adults on three dichotic listening tasks differentiated on the basis of stimulus type (unfiltered words, DFWs) and/or mode of test administration (divided attention [DIV]; directed attention [DIR]). Study sample Thirty-two adults between 18 and 34 yr of age participated in the study. Data collection and analysis Accuracy scores on each ear and normalized values of IA (via laterality index) served as dependent measures evaluated in a repeated-measures ANOVA design. Correlation and regression analyses were carried out to investigate potential relationships between participants' behavioral accuracy to experimental stimuli and the magnitude of observed IA. Behavioral profiles of IA were constructed for each participant. Results Using a traditional DIV test mode, DFW stimuli produced a significantly larger right-ear advantage (REA) as compared to unfiltered speech. The magnitude of the average REA to DFW stimuli was not statistically different between DIV and DIR test modes for the group. Inspection of individual performances, however, revealed that out of the participants who demonstrated meaningful IA during DIV, approximately half produced the same or greater amount of IA during DIR whereas half showed a relative decrease. Participants' accuracy to left-sided stimuli was most related to the magnitude of observed IA across tasks. Conclusions The utility of low-pass filtered speech may be helpful in the evaluation of IA obtained during dichotic testing.
A cohort study on the health effect by hepatitis B virus infection

Objective: To investigate the health status affected by hepatitis B virus(HBV) infection.Methods: A prospective cohort study was established in Haimen City,a high endemic area of hepatocellular carcinoma(HCC) in Jiangsu Province.An epidemiological survey was performed for each research subject.Peripheral blood sample was collected to detect HBsAg and other related indicators.The vital status and cause of death of each cohort member was followed up once a year.Using HBsAg(+) as the indicators of HBV infection,the whole cohort was divided into two groups,one was exposure group,the other was control group.By comparing the death density of these two groups,COX proportional hazard model was applied to evaluate the hazard ratio(HR) of HBV infection in the pathogenesis of HCC.Results: The death density of explore group was 1482.35 per 10 thousand person a year,which was 3.42 times of the control group.HCC was the leading cause of death in the research group and accounted for 52.28% of total deaths.Compared to the control group,the relative risk(RR) was 15.63,the attributable risk(AR) was of 93.60%;for males,HR was 22.3,95%,CI ranged from 18.7～26.6;HR was 37.2,95%,CI ranged from 19.1～72.5 in females.Conclusion: HBV infection did take affect on body's health obviously.
Dielectric properties of polybutadiene and its reinforced composites at room and elevated temperature

With many dielectric materials the dielectric constant does increase with temperature; this is due to the softening of the polymeric network. Greater rotation of the molecular dipole at elevated temperature has been attributed to friction increase, which, in turn, increases its loss factor. Loss factor, a product of dielectric constant and loss tangent, is proportional to the microwave energy dissipated in the material. The equation relating the loss factor and dissipated energy per unit volume is given by: W (energy dissipated/volume) = constant Xϵ″fE2 where ϵ″: loss factor f: frequency E: field intensity.
Morbid obesity does not disadvantage patients with in situ or early-stage carcinoma undergoing breast-conserving surgery.

Aim To determine whether morbidly obese (MO) patients with early-stage breast cancer (BCa) benefit from standard-of-care interventions. Patients and methods Between 1992 and 2005, 100 patients underwent breast-conserving surgery and postoperative whole-breast irradiation of 50 Gy for minimally invasive BCa with tumor-free surgical margins. Twenty-seven MO women were compared to 73 non-morbidly obese (NMO) patients. Results At 10 years, the cumulative disease-free survival rate for the NMO patients was 91% compared to the non-statistically significant lower rate of 89% in the MO women (p=0.66). Patients who were excessively obese were not at an increased risk for local (p=0.99) or regional disease recurrence (p=0.29). Conclusion The results suggest that patients with minimally invasive BCa and excessively large body habitus should not be disqualified from receiving breast-conserving therapy.
Response to “Issues of Academic Support and Performance of Division I Student-Athletes: A Case Study at the University of Minnesota”

“Issues of Academic Support and Performance of Division I Student-athletes: A Case Study at the University of Minnesota” (Kane, Leo, & Holleran, 2008) describes the process used by the University of Minnesota to examine the current state of academics and make data-based recommendations for the improvement of academic support for student-athletes. This paper serves as a benchmark paper for university administrators, faculty, and athletics departments. Many universities have undertaken self-examination in parallel efforts, but few have either documented their process and/or been willing to publicly share the process or the data. The papers’ authors provide important insights into the factors leading to meaningful examination of the issues and the politics leading to significant changes. Too often, in program evaluation (which this study truly was), the investigator fails to incorporate the necessary steps to ensure the identification of the appropriate questions, to gather data to adequately address critica...
Hepatic resection for metastatic breast cancer: an exercise in selection bias.

In this edition of HPB, Margonis1 and colleagues analyze a large multi-institutional series of patients with metastatic breast cancer to the liver treated with hepatic resection. Only 119 cases were collected over 24 years. As is typical of series like this, the patients presented with favorable disease characteristics; they were young (median age 55), presented with long disease-free intervals (median 34 months), tended to have single tumors (median 1) and commonly had estrogen receptor (ER) and/or progesterone receptor positive tumors. At a median follow-up of 2 years, the median overall survival (OS) was 53 months and the 3-year predicted OS was 75%. At last follow-up, 61 of the 119 patients had recurred but among the 45 patients alive without evidence of disease, the median follow up was only 18 months (IQR: 3–44).
Mass spectrometric study of the decomposition pathways of canonical amino acids and α-lactones in the gas phase

The dissociation pathways of a gas-phase amino acid with a canonical (non-zwitterionic) α-amino acid moiety are studied by using mass spectrometry. Investigation of the canonical amino acid moiety is possible because the ionized amino acid, a sulfonated phenylalanine, has a charge center that is separated from the amino acid, and dissociation occurs by charge-remote fragmentation. The amino acid is found to dissociate only by loss of NH3 upon collision-induced dissociation to form a substituted α-lactone. The dissociation is consistent with what has been observed previously upon pyrolysis of other α-substituted carboxylic acids. Decarboxylation, which has also been reported previously for amino acid pyrolysis, is not observed, likely because the product would be a high-energy, ammonium ylide. The resulting α-lactone is found to undergo dissociation by decarbonylation to give an aldehyde, and by loss of CO2. Decarboxylation is calculated to occur through a transition state involving hydride shift coupled with lactone ring-opening. The transition state is found to be stabilized by the negative charge, and therefore, decarboxylation is more favorable for anions. The results show that remote ionic groups can be used as mostly inert charge carriers to enable mass spectrometry to be used to investigate the gas-phase physical and chemical properties of different types of functional groups, including amino acids. Copyright © 2015 John Wiley & Sons, Ltd.
Concept Analysis of Risk Behavior in the Context of Adolescent Development

The term risk behavior is a concept that has been used in the literature for many years, particularly as it relates to adolescent developmental issues and adolescent health behaviors. Currently the literature specific to the conceptual analysis of risk behavior is limited and relates in general to adults, rather than youths. The purpose of this investigation was to analyze not only the concept of risk behavior, but also its specific relationship to adolescents. Previous conceptual analyses have not considered how those concepts may be affected by the psychosocial development of adolescents. Therefore the specific aim of this analysis is to clarify the concept of risk behavior as it relates to youths. Following the process outlined by Walker and Avant (1995) the critical attributes, antecedents, consequences, and empirical referents for the concept of risk behavior are presented in this article.
Extended Kalman Filter combined with fuzzy rules for localization using wireless transceivers

Estimating position of moving objects have been an area of research for several decades, but challenges still remain as many of technologies or computational methods are either too costly, computationally intensive, or simply not possible to apply due to environmental, economical, or other types of constraints. In this paper we investigate a novel method for improving position estimation of a moving object using fuzzy rules in combination with Extended Kalman Filter (EKF) and Received Signal Strength Indicator (RSSI) measures. The EKF provides a recursive method for estimating internal states of nonlinear system from measured observations. The estimation performance of EKF is highly dependent on the dynamics of internal system model, which is not always available, as could be the case for the hidden locations of humans, robots, and animals moving according to their own rules. Preliminary results have shown evidence that when fuzzy rules are considered to represent the dynamical system, a reduction of error occurs, and as a result, a less conservative estimation of position is obtained when compared to the traditional weighted least-square estimate in the context of recursive approach.
Verteporfin exhibits YAP-independent anti-proliferative and cytotoxic effects in endometrial cancer cells.

// Venkata Ramesh Dasari 1 , Virginia Mazack 1 , Wen Feng 2 , John Nash 1 , David J. Carey 1 , Radhika Gogoi 1 1 Weis Center for Research, Geisinger Medical Center, Danville, PA, USA 2 Henry Hood Center for Health Research, Geisinger Medical Center, Danville, PA, USA Correspondence to: Radhika Gogoi, email: rpgogoi@geisinger.edu Keywords: endometrial carcinoma, hippo pathway, verteporfin, YAP, organoids Received: October 07, 2016 Accepted: January 24, 2017 Published: February 22, 2017 ABSTRACT Endometrial Carcinoma (EMCA) is the most common gynecologic malignancy and the fourth most common malignancy in women in the United States. Yes-associated protein (YAP) is a potent transcription coactivator acting via binding to the TEAD transcription factor, and plays a critical role in organ size regulation. Verteporfin (VP), a benzoporphyrin derivative, was identified as an inhibitor of YAP-TEAD interaction. We investigated the therapeutic efficacy and mechanism of VP in EMCA. The efficacy of VP on cell viability, cytotoxicity and invasion was assayed in EMCA cell lines. An organoid model system was also developed to test the effect of VP on apoptotic markers in an in vitro model system. Treatment with VP resulted in a decrease in cell viability, invasion and an increase in cytotoxicity of EMCA cells. These effects occurred as early as 15 minutes following treatment. Similarly, VP treatment versus vehicle control increased apoptosis in human organoid model systems. Quantitative RT-PCR, cDNA based RTPCR array analysis and western blotting were performed to investigate the mechanism of VP action. The cytotoxic and anti-proliferative effects appeared to be independent of its effect on YAP. Our results suggest that VP is a promising chemotherapeutic agent for the treatment of endometrial cancer.
Identification of rat brainstem multisynaptic connections to the oral motor nuclei in the rat using pseudorabies virus. II. Facial muscle motor systems

The present experiments continue our investigations of the higher order afferent systems controlling the orofacial musculature. Pseudorabies virus (PRV) was injected into the buccinator, platysma, posterior digastric, and zygomatic muscles in bilaterally sympathectomized rats. Injection volumes ranged from 6 to 12 microl with average titers of 7 x 10(8) pfu/ml and maximum survival times of 96 h. The labeling patterns and distributions were similar across the individual muscles and between muscle groups (perioral vs. posterior digastric), as well as in comparison to the results from previous masticatory muscle injections. Injections produced a predictable myotopic labeling pattern in the facial motor nucleus (Mo 7) and transneuronally in regions known to project directly to Mo 7 including the red nucleus, ventrolateral parabrachial region, principal trigeminal sensory nucleus, supratrigeminal area, and the parvicellular reticular formation. Maximum survival times revealed more distant connections from a variety of nuclear zones including the periaqueductal gray, laterodorsal and pedunculopontine tegmental areas, and the substantia nigra in the midbrain, ventromedial reticular regions including the gigantocellular region and pars alpha and ventralis in the pons and medulla, and the nucleus of the solitary tract, spinal trigeminal nucleus caudalis, paratrigeminal region, and paramedian field in the medulla. The similarity of the labeling patterns and distributions of the higher order afferents resulting from PRV facial and masticatory muscle injections identifies the neural circuits that may coordinate the activity of these muscle groups during oral motor behavior.
Jetstream atherectomy and balloon angioplasty with distal embolic protection for Angio-Seal related vascular access complications.

Arteriotomy closure devices (ACDs) are routinely used for vascular closure during invasive cardiovascular procedures. They decrease time to hemostasis as well as length of stay. Major complications such as arterial ischemia and occlusion can be encountered in a minority of patients. We are describing a series of 3 patients with access site closure using Angio-Seal after coronary angiography who developed intermittent claudication within 2–3 weeks of follow-up. Access site thrombosis/stenosis in the CFA was found in all the three cases. They were successfully revascularized using Jetstream atherectomy with embolic protection filter followed by balloon angioplasty. This technique can treat extensive thrombus burden as well as extract the collagen and foot plate of Angio-Seal through atherectomy with cutting blades and thrombectomy via rheolytic macerating aspiration port. All cases had excellent angiographic and clinical results.
Immersive Technologies and Experiences for Archaeological Site Exploration and Analysis

Immersive technologies have the potential to significantly improve and disruptively change the future of education and research. The representational opportunities and characteristics of immersive technologies are so unique that only the recent development in mass access fostered by heavy industry investments will allow for a large-scale assessment of the prospects. To further our understanding, this paper describes a project that aims at creating a comprehensive suite of immersive applications for archeological sites, including \(360^\circ \) immersive tours, skywalks, and self-guided explorations for education, and immersive workbenches for researchers.
Photoelectrochemical overall water splitting with textured CuBi2O4 as a photocathode

Nanotextured CuBi2O4 photocathodes have been developed for applications toward solar water splitting. Tailoring the CuBi2O4 photocathodes to yield a high photocurrent and a positively large onset potential demonstrates their applicability in a photoelectrochemical tandem cell for entirely solar-driven overall water splitting.
Synthetic recovery of the complete harmonic data set

Harmonic imaging has been a breakthrough for the quality of clinical ultrasound imaging, greatly reducing the acoustic clutter that typically reduces in vivo image quality. The generation of the second harmonic signal by non-linear propagation is optimized for a focused transmission in which focal gain raises the fundamental pressure. However, the signal-to-noise ratio (SNR) of the harmonic backscattered signal is lower than for the fundamental frequency. We demonstrate the application of Retrospective Encoding For Conventional Ultrasound Sequences (REFoCUS), a framework for performing spatial decoding of existing pulse sequences irrespective of transducer or scan geometry, to improve transmit depth of field and SNR in harmonic imaging. Unlike other spatial coding methods, REFoCUS allows for maintaining a transmit focus and the corresponding harmonic generation. We demonstrate the ability to recover the effective transmit element sources that would linearly produce the observed harmonic fields, enabling individual transmit element processing. The technique is applied to in vivo liver and fetal targets to produce improved image quality away from the original transmit focal depth using the same data.
Who needs more than standard care? Treatment moderators in a randomized clinical trial comparing addiction treatment alone to addiction treatment plus anxiety disorder treatment for comorbid anxiety and substance use disorders.

Abstract Introduction Understanding for whom treatments exert their greatest effects is crucial for prescriptive recommendations that can improve overall treatment efficacy. Anxiety and substance use disorder comorbidity is prevalent and a significant public health concern. Little is known about who should receive specialized, integrated treatments to address both problems. This study aimed to examine baseline patient characteristics that predict differential outcome between typical treatment for substance use disorders (UC) compared to that treatment combined with cognitive behavioral therapy for anxiety disorders (UC + CALM ARC). Methods We examined several putative treatment moderators in a dataset of community-based participants (N = 75) from a randomized clinical trial at an outpatient community substance use disorder (SUD) specialty clinic. Participants who met criteria for any anxiety disorder and any SUD were randomized to UC (the Intensive Outpatient Program at the clinic) or UC + CALM ARC. Outcome measures included anxiety symptoms, drug use, and alcohol use, and were assessed at pre-treatment, post-treatment, and a 6-month follow-up assessment. Results Older age and female gender were associated with greater improvement on anxiety outcomes in UC + CALM ARC compared to UC. The presence of an alcohol use disorder was associated with greater improvement in alcohol use in UC + CALM ARC compared to UC. Higher opiate-related withdrawal symptoms and the presence of more SUDs were associated with greater improvement in drug use outcomes in UC + CALM ARC compared to UC. Conclusions Several pre-treatment characteristics are associated with a return of symptoms for those who receive only UC, whereas the addition of CALM ARC prevented the return of symptoms. Implications for future research and preliminary clinical recommendations are discussed.
Racial and Ethnic Differences in Graft Loss Among Female Liver Transplant Recipients.

Abstract Background Racial differences in post-liver transplantation (LT) outcomes are identified in predominantly male cohorts. Despite known sex differences in a spectrum of liver-related outcomes, it is not known how race influences graft outcomes in women. Methods Using the Scientific Registry of Transplant Recipients, we examined race and ethnicity and graft loss (death or retransplant) in women transplanted from 2002 to 2012. Covariates included recipient and donor characteristics, socioeconomics, and medical comorbidities. Results The eligible cohort (n = 15,860) included 11,051 Caucasians, 2171 Hispanics, 1876 African Americans (AAs), and 762 Asian women with median follow-up of 3.1 years. Five-year graft survival was lower in AA women (60%) compared with Caucasians (71%), Hispanics (70%), and Asians (73%) (P Conclusion Younger AA women are at particularly high risk for graft loss, which predominates in the first 2 years post-LT. Prospective studies of immunosuppression adherence and pharmacokinetics, particularly in relation to patient age, may help to explain the mechanisms underlying the higher rates of graft loss in younger AA women.
Phase stability and reactions of chromite with carbon

Thermodynamic phase stability diagrams of Fe-C-0 and Cr-C-0 systems for several temperatures were constructed. The rate of reaction of FeCr04 with carbon was determined by weight loss measurement technique using TGA. The effect of temperature, Fe/C molar ratio and particle size on reaction rates were determined. The kinetics of the chromite-carbon reaction were modeled using a diffusion controlled model. Based on the deduced activation energy (1 Kcal) and inverse square dependence of chromite particle size, it was concluded that the rate of reaction of chromite with carbon was controlled by the diffusion process. The possible reaction mechanisms and scheme of reaction steps are discussed.
Friction Ridge Print Examination – Interpretation and the Comparative Method

This article is an overview and discussion of the comparative method used for friction ridge print examinations. Analysis, Comparison, Evaluation, and Verification (ACE-V) is a holistic approach to examinations used in many comparative sciences. This article discusses ACE-V, as it is applied to friction ridge print examination. It addresses the theoretical and practical aspects of friction ridge print examinations including topics such as documentation of examinations, conflict resolution, effects of bias on examinations, and blind verification.
Modeling Chronic Graft Versus Host Disease in Mice Using Allogeneic Bone Marrow and Splenocyte Transfer

This unit describes a method for allogeneic bone marrow and splenocyte transfer for the modeling of chronic graft versus host disease (cGVHD) in mice. Preclinical models provide clinically relevant platforms for mechanistic and therapeutic studies that may inform the treatment of patients suffering from cGVHD, a common and potentially severe complication of allogeneic hematopoietic stem cell transplantation (alloHSCT). Most murine models of cGVHD depend on the transfer of major histocompatibility complex (MHC)-mismatched bone marrow and whole splenocytes (or purified T cells) into an irradiated recipient. The bone marrow contains hematopoietic stem and progenitor cells necessary to reconstitute the irradiated host hematopoietic system, while splenocytes contain T cells that mediate cGVHD. Of note, specific mouse strains, splenocyte dose, bone marrow quantity, and irradiation doses vary widely across different cGVHD models. Here we describe donor bone marrow and splenocyte preparation, recipient irradiation and intravenous injection of donor cells, and clinical monitoring for disease emergence and progression. © 2018 by John Wiley & Sons, Inc.
Prepectoral Breast Reconstruction in the Setting of Postmastectomy Radiation Therapy: An Assessment of Clinical Outcomes and Benefits.

Background Prepectoral breast reconstruction following mastectomy has become a more widely performed technique in recent years because of its numerous benefits for women. These include full pectoralis muscle preservation, reduced loss of strength, reduced pain, and elimination of animation deformity. As with any breast reconstruction technique, widespread adoption is dependent on a low morbidity profile in the setting of postmastectomy radiation therapy, as this adjuvant therapy is routine in breast cancer treatment. The authors assess the clinical outcomes of patients undergoing postmastectomy radiation therapy following prepectoral breast reconstruction, and compare these to outcomes of patients undergoing postmastectomy radiation therapy with submuscular reconstruction. Methods A single surgeon's experience with immediate prepectoral breast reconstruction, followed by postmastectomy radiation therapy, from 2015 to 2017 was reviewed. Patient demographics and incidence of complications during the tissue expander stage were assessed. In addition, the morbidity profile of these patients was compared to that of patients undergoing submuscular/dual-plane reconstruction and postmastectomy radiation therapy over the same period. Results Over 3 years, 175 breasts underwent immediate prepectoral reconstruction, and 236 breasts underwent immediate submuscular/dual-plane reconstruction. Overall rates of adjuvant radiation therapy (postmastectomy radiation therapy) were similar between prepectoral [26 breasts (14.9 percent)] and submuscular [31 breasts (13.1 percent)] (p = 0.6180) reconstruction. There were no significant differences in complication rates between the two reconstructive cohorts, in the setting of postmastectomy radiation therapy, including rates of explantation (15.4 percent versus 19.3 percent; p = 0.695). Conclusions Prepectoral breast reconstruction is a safe and effective option in the setting of postmastectomy radiation therapy. The morbidity profile is similar to that encountered with submuscular reconstruction in this setting. Clinical question/level of evidence Therapeutic, III.
Perioperative Factors Affecting the Length of Hospitalization After Shoulder Arthroplasty.

Objective To determine factors related to length of hospitalization after shoulder arthroplasty. Methods A retrospective review identified patients who underwent shoulder arthroplasty between 2009 and 2012 at our institution. Factors were evaluated for their association with hospitalization length in a univariate model. Diagnoses were categorized into four groups: (1) osteoarthritis, cuff tear arthropathy, massive rotator cuff tear, or osteonecrosis; (2) acute fracture or fracture sequelae; (3) inflammatory arthropathy; and (4) failed shoulder arthroplasty. Significant factors were then evaluated using a multivariate model. Results Four hundred twenty-five shoulder arthroplasties were identified (average age, 66.9 years). Arthroplasty type significantly affected hospitalization length. Significant factors for increased hospitalization using multivariate analysis were diabetes mellitus, American Society of Anesthesiologists score of 3 or 4, acute fracture or fracture sequelae diagnosis, inflammatory arthropathy, and a blood transfusion. Discussion Independent factors using multivariate analysis are diabetes, an American Society of Anesthesiologists score ≥3, fracture or fracture sequelae, inflammatory arthritis, and a perioperative blood transfusion. Level of evidence Level III therapeutic study.
Quantifying length-dependent DNA end-binding by nucleoproteins.

Abstract The ends of nucleic acids oligomers alter the statistics of interior nonspecific ligand binding and act as binding sites with altered properties. While the former aspect of “end effects” has received much theoretical attention in the literature, the physical nature of end-binding, and hence its potential impact on a wide range of studies with oligomers, remains poorly known. Here, we report for the first time end-binding to DNA using a model helix-turn-helix motif, the DNA-binding domain of ETV6, as a function of DNA sequence length. Spectral analysis of ETV6 intrinsic tryptophan fluorescence by singular value decomposition showed that end-binding to nonspecific fragments was negligible at >0.2 kbp and accumulated to 8% of total binding to 23-bp oligomers. The affinity for end-binding was insensitive to salt but tracked the affinity of interior binding, suggesting translocation from interior sites rather than free solution as its mechanism. As the presence of a cognate site in the 23-bp oligomer suppressed end-binding, neglect of end-binding to the short cognate DNA does not introduce significant error. However, the same applies to nonspecific DNA only if longer fragments (>0.2 kbp) are used.
Abstract 3967: Comparison of neoadjuvant FOLFIRINOX alone vs FOLFIRINOX + stereotactic body radiation as immune-modulators of the pancreatic adenocarcinoma microenvironment

Pancreatic ductal adenocarcinoma (PDAC) has dismal five-year survival ( Citation Format: Matthew R. Farren, Walid Shaib, Mohammad Zaidi, Layal Sayegh, David Kooby, Shishir Maithel, Alyssa Krasinskas, Olatunji Alese, Juan Sarmiento, Bassel El-Rayes, Gregory B. Lesinski. Comparison of neoadjuvant FOLFIRINOX alone vs FOLFIRINOX + stereotactic body radiation as immune-modulators of the pancreatic adenocarcinoma microenvironment [abstract]. In: Proceedings of the American Association for Cancer Research Annual Meeting 2019; 2019 Mar 29-Apr 3; Atlanta, GA. Philadelphia (PA): AACR; Cancer Res 2019;79(13 Suppl):Abstract nr 3967.
Invasive Lobular Carcinoma With Extensive Clear Cells: A Pitfall in Diagnosis.

Carcinomas in the breast with a predominantly clear cytoplasm are rare. In this article, we review the differential diagnosis of clear cell breast neoplasms and report a case of invasive lobular ca...
Excision and Autografting of Burn Wound

This chapter describes the surgical procedure for excision and autografting of burn wound as performed by the following approaches: tangential excision of burn wound, harvesting skin graft from donor site and placing harvested graft on prepared burn wound base. The text includes an introduction that outlines the indications, risks, alternatives, essential steps needed equipment, and variations in technique for the procedure in question. This is followed by a template operative dictation, which provides the reader with an operative report, such as is found in a patient chart or electronic medical record. A description is provided of the following critical concepts for this procedure: removal of unhealthy tissue, hemostasis, and wound coverage.
Effects of zinc oxide filler on the curing and mechanical response of alkyd coatings

Abstract The mechanical properties of an alkyd resin filled with zinc oxide pigment were studied at different concentrations over a wide range of time scales using dynamic mechanical analysis, quartz crystal rheometry and nanoindentation. The motivation for this work stems from the interest in accessing the long-term properties of paint coatings by studying the mechanical properties of historic paints. In this foundational work, we compare three different modalities of mechanical measurements and systematically determine the effect of pigment filler loading on the measured properties. Quantitative agreement between the methods is obtained when the characteristic time scales of each of the methods is taken into account. While nanoindentation is the technique most readily applied to historic paint samples, the rheometric quartz crystal microbalance (rheo-QCM) is the best suited for obtaining mechanistic information from measurements of paint properties over time, provided that appropriate thin-film samples can be produced. In these studies we find that ZnO increases the rate of oxidation of the alkyd during the initial stages of cure by an amount that depends on the ZnO content.
Multi-System Inflammatory Syndrome in Children (MIS-C) Following SARS-CoV-2 Infection: Review of Clinical Presentation, Hypothetical Pathogenesis, and Proposed Management

Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infection may result in the multisystem inflammatory syndrome in children (MIS-C). The clinical presentation of MIS-C includes fever, severe illness, and the involvement of two or more organ systems, in combination with laboratory evidence of inflammation and laboratory or epidemiologic evidence of SARS-CoV-2 infection. Some features of MIS-C resemble Kawasaki Disease, toxic shock syndrome, and secondary hemophagocytic lymphohistiocytosis/macrophage activation syndrome. The relationship of MIS-C to SARS-CoV-2 infection suggests that the pathogenesis involves post-infectious immune dysregulation. Patients with MIS-C should ideally be managed in a pediatric intensive care environment since rapid clinical deterioration may occur. Specific immunomodulatory therapy depends on the clinical presentation. The relationship between the immune response to SARS-CoV-2 vaccines in development and MIS-C requires further study.
Obstructive sleep apnea in obese minipigs.

Objective Obesity has reached epidemic proportions and is a strong risk factor for obstructive sleep apnea (OSA). However, the underlying mechanisms are poorly understood and current treatment strategies for OSA and obesity have critical limitations. Thus, establishment of an obesity-related large animal model with spontaneous OSA is imperative. Materials and methods Natural and sedated sleep were monitored and characterized in 4 obese (body mass index - BMI>48) and 3 non-obese (BMI<40) minipigs. These minipigs were instrumented with the BioRadio system under sedation for the wireless recording of respiratory airflow, snoring, abdominal and chest respiratory movements, electroencephalogram, electrooclulogram, electromyogram, and oxygen saturation. After instrumentation, the minipigs were placed in a dark room with a remote night-vision camera for monitoring all behaviors. Wakefulness and different sleep stages were classified, and episodes of apneas and/or hypopneas were identified during natural and/or sedated sleep. Results No hypopnea episodes were observed in two of the non-obese minipigs, but one non-obese minipig had 5 hypopnea events. Heavy snoring and 27-58 apnea and/or hypopnea episodes were identified in all 4 obese minipigs. Most of these episodes occurred in the rapid eye movement stage during natural sleep and/or sedated sleep in Yucatan minipigs. Conclusions Obese minipigs can experience naturally occurring OSA, thus are an ideal large animal model for obese-related OSA studies.
Using Dynamic Data Driven Cyberinfrastructure for Next Generation Disaster Intelligence

Wildland fires and related hazards are increasing globally. A common observation across these large events is that fire behavior is changing to be more destructive, making applied fire research more important and time critical. Significant improvements towards modeling of the extent and dynamics of evolving plethora of fire related environmental hazards, and their socio-economic and human impacts can be made through intelligent integration of modern data and computing technologies with techniques for data management, machine learning and fire modeling. However, there are still challenges and opportunities in integration of the scientific discoveries and data-driven methods for hazards with the advances in technology and computing in a way that provides and enables different modalities of sensing and computing. The WIFIRE cyberinfrastructure took the first steps to tackle this problem with a goal to create an integrated system, data and visualization services, and workflows for wildfire monitoring, simulation, and response. Today, WIFIRE provides an end-to-end management infrastructure from the data sensing and collection to artificial intelligence and modeling efforts using a continuum of computing methods that integrate edge, cloud, and high-performance computing. Through this cyberinfrastructure, the WIFIRE project provides data driven knowledge for a wide range of public and private sector users enabling scientific, municipal, and educational use. This paper (based on the keynote by the author) reviews some of our recent work on building this dynamic data driven cyberinfrastructure and impactful application solution architectures that showcase integration of a variety of existing technologies and collaborative expertise.
MacroJournal – Turning Students into Practitioners

Incorporating currents events into an economics curriculum is a goal of many dedicated instructors. The benefits of doing so are obvious. Unfortunately, the costs associated with implementation are non-trivial. In the following, I introduce an experiential writing assignment, called the MacroJournal, which streamlines the process of incorporating current events into a macroeconomics course. The costs for the instructor are mitigated by a repeated structure of questioning and a well-defined grading rubric. By completing the assignment, students have an opportunity to become practitioners, and link current events to classroom theory.
Understanding Aging in Place: Home and Community Features, Perceived Age-Friendliness of Community, and Intention Toward Aging in Place.

Background and objectives Promoting age-friendliness of communities and supporting aging in place (AIP) are of great importance. Based on processes of belonging and agency, which suggest that person-environment interactions influence residents' evaluations and behaviors related to the environment, this study aims to examine the interrelationship between the availability of age-friendly features, perceived age-friendliness of community, and intention toward AIP. Research design and methods This study used the 2015 AARP Age-Friendly Community Survey, which includes 66 home and neighborhood features under the eight domains specified by the WHO's Age-Friendly Cities Guidelines. A series of regression and mediational analyses were conducted to test hypotheses. Results Overall, a greater availability of age-friendly features was positively associated with perceived age-friendliness of community and AIP intention. The relationship between age-friendly features and AIP intention was mediated by perceived age-friendliness of community (50.3% to 96% of the total effects). When perceived age-friendliness of community was introduced to models, the direct effects of housing, outdoor spaces and buildings, and transportation domains remained significant. Discussion and implications Findings suggest that a greater availability of age-friendly features influences older adults' perception on their community, leading to the development of a desire to age-in-place, supporting processes of belonging and agency. Domains of housing, outdoor spaces and buildings, and transportation may be the most important features in promoting age-friendliness of community and the key determinants of aging in place. Policy makers and practitioners may need to prioritize promoting age-friendly built environment before social environment in building age-friendly communities.
Clinical Study on Different Delivery Methods of Twin Pregnancy.

Objective To investigate the effect of different methods of delivery on the outcome of twin pregnancies. Methods This is a retrospective cohort review of 627 twin pregnancies with delivery from January 2016 to December 2019. According to the clinical guidelines for cesarean section, the cesarean section and vaginal delivery groups were determined. Finally, the baseline information, delivery method, pregnancy outcome, and maternal and infant complications of the two groups were compared. Results For different delivery methods, the incidence of preeclampsia was significantly higher in the cesarean section group than in the vaginal delivery group (χ2 = 4.405, p Conclusion The major complications of a twin pregnancy are gestational diabetes mellitus and PPROM. Cesarean section can reduce the rate of neonatal asphyxia in twins and improve the pregnancy outcome. Key Points
Basic Science of PRP

Platelet-rich plasma (PRP) is increasingly popular for the treatment of hair loss, a common and psychologically taxing condition (Tabolli et al., Am J Clin Dermatol. 14(2):139–45, 2013; Alfonso et al., Curr Med Res Opin. 21(11):1829–36, 2005). PRP has been shown to be a safe and effective adjuvant for the treatment of alopecia. Various techniques for preparation and classification systems have evolved in recent years. This chapter provides an overview of the proposed mechanism of action, classifications, current applications, and techniques for preparation. In addition, the authors report their experience and validated outcomes at a large academic institution. Finally, guides to getting started with PRP and common pitfalls are discussed.
Uses for Highly Descriptive CRM Reports: An Example from the Central Plains

This paper assesses one use of descriptive CRM reports by showing that data in them can indicate the utilization of environmental settings in specific localities over a 12,000 year period and local...
NEWTON'S LAWS

Publisher Summary This chapter discusses the causes of motion. It also presents the concept of force and explains the concept of inertial mass. Newton's first law defines the zero-force environment. In that environment, a particle experiences no influence on its motion. Newton's second law relates the inertial mass and the acceleration of a particle to the net force it experiences. Inertial mass is an intrinsic particle property and it is independent of the environment. The chapter presents the concept of mass by explaining how accelerations and the standard kilogram are used to assign numbers to the masses of unknown particles. It also describes the dependence of acceleration on particle mass. The force concept is completed by Newton's third law that describes in part the mutual interactions of two particles. The third law stipulates that forces in nature must occur in· action–reaction pairs. The chapter examines the role of inertial frames of reference and discusses several laws of force. The law of gravity is given special treatment because of its special importance. In addition, the chapter also explains the relationship between weight and mass. It presents several mechanical laws dealing with the forces exerted by solids and fluids.
Rickettsial diseases of childhood

Summary 1. The clinical manifestations of tick typhus and murine typhus in childhood have been presented and have been correlated, in so far as is possible, with the pathologic and clinical pathologic manifestations of the disease. 2. The general treatment of rickettsial infections in childhood has been presented, together with an outline for the use of para-aminobenzoic acid in these infections.
Techniques and methods for adaptive single antenna radar system polarization optimization for anti jam and anti clutter applications

Antenna polarization refers to the electric field orientation of a radio wave with respect to the earth's surface. It is advantageous for a radar system to be able to alter its antenna polarization due to the varying nature of target geometries, clutter, and unwanted jamming. This novel approach offers a system in which antenna polarization is adapted to match an optimal state determined from the changing electromagnetic environment.
Environmental Regulation of Salmonella typhi Invasion-Defective Mutants

Salmonella typhi is the etiologic agent of human typhoid. During infection, S. typhi adheres to and invades epithelial and M cells that line the distal ileum. To survive in the human host, S. typhi must overcome numerous complex extracellular and intracellular environments. Since relatively little is known about S. typhi pathogenesis, studies were initiated to identify S. typhi genes involved in the early steps of interaction with the host and to evaluate the environmental regulation of these genes. In the present study, TnphoA mutagenesis was used to study these early steps. We isolated 16 Salmonella typhi TnphoA mutants that were defective for both adherence and invasion of the human small intestinal epithelial cell line Int407. Twelve of sixteen mutations were identified in genes homologous to the S. typhimurium invG and prgH genes, which are known to be involved in the type III secretion pathway of virulence proteins. Two additional insertions were identified in genes sharing homology with the cpxA and damX genes from Escherichia coli K-12, and two uncharacterized invasion-deficient mutants were nonmotile. Gene expression of TnphoA fusions was examined in response to environmental stimuli. We found that the cpxA, invG, and prgH genes were induced when grown under conditions of high osmolarity (0.3 M NaCl). Expression of invG and prgH genes was optimal at pH 6.5 and strongly reduced at low pH (5.0). Transcription of both invG and prgH TnphoA gene fusions was initiated during the late logarithmic growth phase and was induced under anaerobic conditions. Finally, we show that both invG and prgH genes appear to be regulated by DNA supercoiling, a mechanism influenced by environmental factors. These results are the first to demonstrate that in S. typhi, (i) the prgH and cpxA genes are osmoregulated, (ii) the invG gene is induced under low oxygen conditions, (iii) the invG gene is pH regulated and growth phase dependent, and (iv) the prgH gene appears to be regulated by DNA supercoiling. Since our experimental conditions were designed to mimic the in vivo environmental milieu, our results suggest that specific environmental conditions act as signals to induce the expression of S. typhi invasion genes.
Howard S. Becker & Robert R. Faulkner, Thinking Together: An E-Mail Exchange and All That Jazz

To convey the flavor of the unique e-book that I am reviewing here, I am commencing this essay in an unusual fashion— with a story about thinking about how to introduce it. In my first attempt to write an opening line, I began with the sentiment that the process of creating new knowledge and writing up research is often a daunting, mysterious task. I chose this opening because I found it to be a useful way to highlight the distinct pedagogical utility of Thinking Together: An E-Mail Exchange and All That Jazz, which offers an incredibly rare look into the “career” of an idea by reconstructing the entire corpus of e-mail correspondence that Howard Becker and Robert Faulkner produced over three years of puzzling through the question that animates their 2009 book Do You Know . . .? The Jazz Repertoire in Action: How do jazz musicians who may have never played together—or who may have never even met—pull off playing a competent performance with no set list? This got me to thinking about how published works seldom offer any trace of the practices that constructed them, which led me to try out a new introductory sentence that invoked commodity fetishism to make this point. However, being dissatisfied with this cute, gratuitous allusion to Marx, I returned my cursor to the top of the screen and began with a summary of Do You Know. After all, I reasoned, Thinking Together derives much of its meaning and value from illuminating the back stage machinations that resulted in the thesis and organization of Do You Know. But this felt problematic to me because placing the printed, bound product of Becker and Faulkner’s years of collaboration at the forefront risked reifying Do You Know as a commodity fetish. Frustrated again, I deleted all of the text and wondered whether I ought to make an outline of the review before attempting to write it.