cssi/SciSciGPT-SciSciNet huggingface dataset:
Metabolic Imaging of Ischemic Heart Disease by Positron Emission Tomography

Over the last decade many new invasive and non-invasive technologies have been developed to characterize ischemic heart disease. Coronary artery disease can be detected with high sensitivity and specificity by using non-invasive imaging approaches. At the same time, diagnostic coronary angiography has become a safe and widely accepted invasive procedure for characterizing the extent and severity of coronary artery disease. Regional and global assessment of function, perfusion, and coronary anatomy have been shown to provide important diagnostic and prognostic information in acute and chronic disease. However, diagnostic problems persist in efforts to define tissue viability in patients with advanced coronary artery disease. Since many large clinical studies have shown that patients with impaired left ventricular function benefit most from revascularization, the diagnostic differentiation between infarcted and ischemically compromised, but viable, myocardium has become of major clinical importance. Functional evaluation by radionuclide ventriculography or echocardiography does not allow for separation of irreversible and reversible tissue injury, especially early after myocardial infarction. Delayed functional recovery (stunned myocardium) [8] and chronically depressed function of hypoperfused myocardium (hibernating myocardium) [38] have been recently recognized as clinical entities. Thallium-201 stress imaging has been widely used to separate ischemic viable myocardium from scar tissue.
ESTIMATION OF THE COANCESTRY COEFFICIENT: BASIS FOR A SHORT-TERM GENETIC DISTANCE

ABSTRACT A distance measure for populations diverging by drift only is based on the coancestry coefficient θ, and three estimators of the distance D = - ln (1 - θ) are constructed for multiallelic, multilocus data. Simulations of a monoecious population mating at random showed that a weighted ratio of single-locus estimators performed better than an unweighted average or a least squares estimator. Jackknifing over loci provided satisfactory variance estimates of distance values. In the drift situation, in which mutation is excluded, the weighted estimator of D appears to be a better measure of distance than others that have appeared in the literature.
Nonlinear fibers for signal processing using optical Kerr effects

This paper reviews nonlinear optical-fiber designs for signal processing using optical Kerr effects. The requirements for designing nonlinear fibers are described first. Then, the design concept is discussed and design examples are shown to illustrate the tradeoffs among the different fiber properties such as effective area, dispersion, and attenuation. Furthermore, fiber designs with distributed Brillouin frequency shift to mitigate the effect of simulated Brillouin scattering (SBS) in nonlinear fibers are discussed in detail. An SBS-threshold increase of 7 dB over conventional nonlinear fibers is experimentally demonstrated.
Offering language based services on social media by identifying user's preferred language(s) from romanized text

With the increase of multilingual content and multilingual users on the web, it is prudent to offer personalized services and ads to users based on their language profile (\textit{i.e.}, the list of languages that a user is conversant with). Identifying the language profile of a user is often non-trivial because (i) users often do not specify all the languages known to them while signing up for an online service (ii) users of many languages (especially Indian languages) largely use Latin/Roman script to write content in their native language. This makes it non-trivial for a machine to distinguish the language of one comment from another. This situation presents an opportunity for offering following language based services for romanized content (i) hide romanized comments which belong to a language which is not known to the user (ii) translate romanized comments which belong to a language which is not known to the user (iii) transliterate romanized comments which belong to a language which is known to the user (iv) show language based ads by identifying languages known to a user based on the romanized comments that he wrote/read/liked. We first use a simple bootstrapping based semi-supervised algorithm for identify the language of a romanized comment. We then apply this algorithm to all the comments written/read/liked by a user to build a language profile of the user and propose that this profile can be used to offer the services mentioned above.
An assessment of generalizability of Internet surveys

The Internet has become an increasingly popular form of data collection because it permits complex questionnaires to be administered more quickly, flexibly, and inexpensively than conventional surv...
The Present Moment and Implicit Communication in Group Psychotherapy

Abstract The importance of the concepts of present moment and implicit communication to group psychotherapy is discussed in relation to the articles by Gans and by Counselman and Abernethy and to the life work of Anne Alonso. Clinical examples are used to illustrate the discussion.
Enthalpy of hydrogen‐containing hydrocarbon liquids

The partial enthalpy of dissolved hydrogen in hydrocarbon liquids is derived from the fugacity correlation of Sebastian et al. and the results are presented in general equations. The partial enthalpy of the hydrocarbon solvent is found to be changed only insignificantly by the dissolved hydrogen from that of the pure liquid at the experimental conditions of up to 30 MPa in pressure.
Hintikka’s Epistemic Logic

All language is rule-governed, and the language of epistemology is no exception. The advent of the tools of modern symbolic logic has made it increasingly possible to investigate various uses of language by formalizing the language, i.e. enshrining the rules in a formal logic. Thus we have seen in the last century the development of modal logic (the logic of necessity and possibility), deontic logic (the logic of obligation and permission), temporal logic (the logic of time), and epistemic logic (the logic of knowledge and belief). The first attempt to formalize the language of epistemology seems to have been made by Georg von Wright (1951). Unfortunately, this was not a particularly penetrating analysis, being really tangential to von Wright’s main purpose, which was an investigation into the logic of the alethic modalities. The first thoroughgoing epistemic logic was constructed by Hintikka (1962). (I shall label this system ‘KB’ for ease of reference since, to the best of my knowledge, it has no other label, and its basic formulation is in Hintikka (1962).)
Atomic-level study of twin nucleation from face-centered-cubic/body-centered-cubic interfaces in nanolamellar composites

We report deformation twinning in Cu within accumulative roll-bonded Cu-Nb nanolamellar composites. Twins appear connected to the Nb{112}//Cu{112} interface with the Kurdjumov-Sachs orientation relationship, which we show to be ordered and faceted. The interface adopts a different faceted structure after twinning. Our analysis suggests that deformation twinning involves facet dissociation and slip-transfer from the Nb layer to the Cu layer due to a geometrically favorable slip transmission pathway.
PULSE DETONATION TUBE CHARACTERIZATION USING LASER ABSORPTION SPECTROSCOPY

The time-resolved OH concentration and gas temperature are measured in the Stanford University pulse detonation tube facility using CW, UV laser absorption. OH is monitored by direct absorption of the R21(5) and S21(1) transitions in the 0, 0 band of the A-X system. Gas temperature is determined from UV CO2 absorption. Results from these diagnostics are useful in verifying computational simulations and in advancing PDE design and development.
Allostatic Perspectives in Women Veterans With a History of Childhood Sexual Assault

BACKGROUND: Women veterans have increased reports of sexual victimization compared to women in general, including childhood sexual assault (CSA) before military service, increasing the risk of military sexual trauma. FINDINGS from recent studies reveal negative health effects following a history of CSA. There is a strong relationship between CSA and revictimization in civilian and military life, which may contribute to allostatic load. OBJECTIVES: (1) To determine the relationship between women veterans' CSA history and later sexual assault history and (2) to determine the relationships between women veterans' CSA and primary mediators and secondary and tertiary outcomes of allostasis. RESEARCH DESIGN: Cross-sectional. SUBJECTS: Women (N = 81), 18-70 years old, veterans of the U.S. Armed Services. MEASURES: Participants completed questionnaires and blood and hair samples were collected. Several scales were utilized: Posttraumatic Checklist-Military, Center for Epidemiological Studies-Depression Scale, Pain Outcomes Questionnaire-Short Form, Cohen's Perceived Stress Scale (PSS), Profile of Mood States, and an investigator-developed sexual harassment/assault instrument. RESULTS: Thirty-three percent of participants reported CSA; of these, 38.5% reported military sexual assault and 70.3% sexual assault during civilian life. Those with CSA had higher cholesterol, triglycerides, perceived stress scores, and greater pain and fatigue than those without CSA. Hair cortisol was marginally lower in women with CSA when PSS was controlled, suggesting a dampened hypothalamic-pituitary-adrenal axis. CONCLUSIONS: These data suggest that some women veterans with a history of CSA may have increased allostatic load and be at increased risk for a variety of later life illnesses.© The Author(s) 2016. Language: en
Distirbution,identification and amino acid composition analysis of proteins in the secondary precipitate of soy sauce

In this paper,proteins in the supernatant of soy sauce were used as control,and the secondary precipitate of soy sauce were prepared by static settlement-lyophilization.The molecular weight distribution,amino acid composition and average hydrophobicity of proteins in the secondary precipitate of soy sauce were investigated by N-Tris[Hydroxymethyl]Methylglycine-sodium dodecyl sulfate-polyacrylamide gel electrophoresis( Tricine- SDS- PAGE) and high- performance liquid chromatography( HPLC),then proteins in the secondary precipitate of soy sauce were identified by matrix- assisted laser desorption ionisation- time of flight /time of flight mass spectrometry( MALDI- TOF/TOF MS). Results showed that proteins with molecular weights of approximate22.7ku( 80.20%,the basic polypeptide B3of soy glycinin G4) and 34.1ku( 19.80%,the acidic polypeptide A1a of soy glycinin G1) were identified as the majority of proteins in the secondary precipitate of soy sauce. Furthermore,remarkable difference in amino acid compostion was observed between proteins in the supernant and the secondary precipitate of soy sauce,average hydrophobicity analysis showed that average hydrophobicity of proteins in the secondary precipitate was significantly higher than that in proteins of the supernatant. This work could contribute to the systematical knowledge of proteins in the secondary precipitate of soy sauce,and shed some light on its solving way.
Environmental Behavior's Dirty Secret: The Prevalence of Waste Management in Discussions of Environmental Concern and Action.

Humankind and the planet face many thorny environmentally related challenges that require a range of responses, including changing behaviors related to transportation, eating habits, purchasing, and myriad other aspects of life. Using data from a 1201-person survey and 14 Community Listening Sessions (CLSs), we explore people’s perceptions of and actions taken to protect the environment. Our data indicate a striking prevalence of waste management-related actions. Survey respondents described actions and concerns related to trash, recycling, and composting as the most common environmental behaviors; similarly, participants in CLSs discussed waste-related topics, for which we did not prompt, as frequently as those topics for which we specifically prompted. Explanations for this prevalence emerging from the data include (1) the nature of waste-related behaviors (concrete, supported by infrastructure, simple, compatible with lifestyle); (2) norms and social dynamics (family interactions, feelings of belonging/participation, government policy); and (3) internal psychological processes (internalized norms and environmental concern). We also found that many waste-related discussions were relatively superficial, focusing on immediate waste-related issues (e.g., litter or recycling) rather than larger issues such as consumption. Our results may provide insight into future efforts to encourage pro-environmental behavior. Given that most pro-environmental behavior involves tasks more complex and lifestyle-changing than those related to simple aspects of waste management, we suggest focusing on the latter two intertwined categories that our data suggest are important: encouraging social dynamics and related development of norms concerning environmental behavior (category 2), and fostering internalized norms and environmental concern (category 3).
A solid phase radioimmunoassay for prostatic acid phosphatase.

AbstractThe sensitivity of a recently developed solid phase radioimmunoassay for human prostatic acid phosphatase was compared to that of an enzymatic method using p-nitrophenylphosphate as substrate. In 109 histologically verified untreated stages I to IV prostatic cancers and 200 men without such cancer the solid phase radioimmunoassay method demonstrated substantially greater sensitivity and specificity than the enzymatic technique. In the 109 prostatic malignancies the immunochemical method correctly classified 80 (73 per cent) versus 34 (31 per cent) for the p-nitrophenylphosphate enzymatic technique (p < 10−6). In 44 stages I and II cancers confined to the prostate the radioimmunoassay was abnormally elevated in 19 (43 per cent) with only 4 (9.1 per cent) enzymatic elevations (p < 10−3). In 65 stages III and IV extraprostatic cancers correct classifications were noted in 61 (94 per cent) of the radioimmunoassays and 30 (46 per cent) enzymatic tests (p < 10−6). The radioimmunoassay in 200 male contro...
The Effect of Parental Warmth on Girls’ Drive for Thinness: Do Both Parents Matter?

Research has suggested that both maternal and paternal warmth play a role in the development of drive for thinness (DFT) in girls, yet parents have only been examined as unique predictors, or as one unit; therefore, we sought to investigate how maternal and paternal warmth combined to affect girls’ DFT. Furthermore, until the present study, the effect of parental warmth on parental pressure to be thin was unstudied. Using self-reports from 115 females (ages 12–19), we were able to determine the impact of parental warmth and pressure to be thin on girls’ DFT, dependent on whether parents had similar or differing warmth levels. Parental warmth was measured using the Care subscale of the Parental Bonding Instrument, parental pressure to be thin was measured using an adapted version of the Perceived Sociocultural Pressure Scale, and DFT was measured using the DFT subscale of the Eating Disorders Inventory. Results indicated that when parents had differing levels of warmth, the relationship between warmth and DFT was fully mediated by pressure to be thin. However, when parents had similar warmth, there was a remaining direct effect between parental warmth and girls’ DFT, indicating partial mediation. In addition, not only was parental warmth negatively associated with parental pressure, but when both parents had high warmth, girls were less affected by pressure. These findings suggest that having two parents who are high in warmth may serve as a protective factor against DFT in adolescent girls, both directly via less DFT in general, and indirectly by lowering the impact of parental pressure.
Marxism and Marketing

Theories of Karl Marx about capitalism, class conflict, false consciousness, and alienation in bourgeois societies are explained and the way Marxist theorists approach everyday life and culture. It is asserted the capitalism shapes cultures and this must be kept in mind when thinking about marketing and advertising in capitalist countries. It is suggested that, until recently, marketers were able to channel alienation in the working classes into consumption and thus prevent the masses from recognizing the degree to which they were being exploited by members of the ruling class. Now that there is widespread concern about income inequality, marketers must rethink how they function in society.
Does the Predictive Validity of Psychopathy Ratings Depend on the Clinical Experience of the Raters

ABSTRACTWe compared the predictive validity of Psychopathy Checklist- Revised (PCL-R; Hare, 2003) scores assigned to 80 sexual offenders by two trained graduate students (using file review) and at least one licensed clinician (using file review and interview). There was more variability among the scores assigned by the licensed clinicians than those assigned by the graduate students, and the scores assigned by licensed clinicians were stronger predictors of future offending than those assigned by the graduate students. Findings raise questions about a possible association between clinical experience and PCL-R score validity and highlight the need for more research in this area.
Co-Calculus: Integrating the Academic and the Social

Being part of a cohesive learning community supports retention and success in early mathematics courses. Yet, large, unwelcoming lectures stand in opposition to this goal, isolating students and pushing them away from STEM. This paper offers a comparative analysis of three efforts to build community amongst students, all situated within a single large-lecture introductory calculus course at a diverse, research-extensive institution. These programs were: (1) active learning labs, targeted at all students, (2) a small-group seminar for commuter students, and (3) a workshop model targeted at “underserved” students in STEM. Of these three efforts, only the workshop model had a significant impact on student success. Social networks within the workshop section suggest that students were able to integrate their academic and social experiences to a greater extent than the other sections. These results suggest that active learning and co-calculus experiences alone may be insufficient to foster cohesive social and academic bonds, unless properly organized.
LITMUS: Towards Multilingual Reporting of Landslides

LITMUS is a real-time online and openly accessible service that collects high quality information on landslide events from social media. This service uses disaster related keywords, such as "landslide" and "mudslide", to analyze messages posted by English speaking users. However, comprehensive coverage of disasters must include multilingual support as there are events that are reported in languages other than English. We discuss and evaluate possible implementations of such support using "native" and "translated" approaches. "Native" approach involves a complete reimplementation of the existing infrastructure in another language whereas in the "translated" approach the existing infrastructure can be used without modification. As an illustration, we present a demo that extends LITMUS to implement a "native" approach for multilingual reporting of landslide events.
Beyond Paralogs: The Multiple Layers of Redundancy in Bacterial Pathogenesis

Redundancy has been referred to as a state of no longer being needed or useful. Microbiologists often theorize that the only case of true redundancy in a haploid organism would be a recent gene duplication event, prior to divergence through selective pressure. However, a growing number of examples exist where an organism encodes two genes that appear to perform the same function. For example, many pathogens translocate multiple effector proteins into hosts. While disruption of individual effector genes does not result in a discernable phenotype, deleting genes in combination impairs pathogenesis: this has been described as redundancy. In many cases, this apparent redundancy could be due to limitations of laboratory models of pathogenesis that do not fully recapitulate the disease process. Alternatively, it is possible that the selective advantage achieved by this perceived redundancy is too subtle to be measured in the laboratory. Moreover, there are numerous possibilities for different types of redundancy. The most common and recognized form of redundancy is functional redundancy whereby two proteins have similar biochemical activities and substrate specificities allowing each one to compensate in the absence of the other. However, redundancy can also exist between seemingly unrelated proteins that manipulate the same or complementary host cell pathways. In this article, we outline 5 types of redundancy in pathogenesis: molecular, target, pathway, cellular process, and system redundancy that incorporate the biochemical activities, the host target specificities and the impact of effector function on the pathways and cellular process they modulate. For each type of redundancy, we provide examples from Legionella pathogenesis as this organism employs over 300 secreted virulence proteins and loss of individual proteins rarely impacts intracellular growth. We also discuss selective pressures that drive the maintenance of redundant mechanisms, the current methods used to resolve redundancy and features that distinguish between redundant and non-redundant virulence mechanisms.
The Evolving Role of Intranasal Dexmedetomidine for Pediatric Procedural Sedation.

For decades, chloral hydrate (CH) was the standard agent used to provide sedation for noninvasive pediatric procedures.1 The drug had a long history of safe administration by nonanesthesia providers, which in many institutions included registered nurses.2,3 Despite reasonably high reported rates of success, CH had a number of disadvantages: a variable half-life in young children, clinical resedation, and a potential role as a neuroapoptotic agent in the developing brain.4,5 Perhaps the greatest disadvantage was the loss of the oral formulation in the US market, limiting its availability. After the loss of oral CH, many institutions evolved to an intravenous (IV) sedation regimen with propofol.6 Propofol was an attractive agent because of its high success rate, rapid onset, and short recovery. However, this change in practice presented new challenges because propofol is typically administered only by pediatric providers with advanced training in deep sedation or anesthesiologists. These deep sedation systems often require more intensive resource utilization (IV catheter placement, advanced monitoring systems, postanesthesia care, etc), which may have economic consequences for both the patient and the health care system. For many years, IV dexmedetomidine has been used for sedation in the critical care setting.7 In 2008, Mason et al8 took …
Electronic cardiac arrest triage score best predicts mortality after intervention in patients with massive and submassive pulmonary embolism

Objective To determine if the cardiac arrest triage (CART) Score would better predict poor outcomes after pharmacomechanical therapy (PMT) for massive and submassive pulmonary embolism (PE) than traditional risk scores BACKGROUND: PMT for massive and submassive PE allows for clot lysis with minimal doses of fibrinolytics. Although PMT results in improved right ventricular function, and reduced pulmonary pressures and thrombus burden, predictors of poor outcome are not well-studied. Methods We conducted a retrospective analysis of all patients who underwent PMT for massive or submassive PE at a single institution from 2010 to 2016. The CART score and electronic CART (eCART) score, derived previously as early warning scores for hospitalized patients, were compared to pulmonary embolism severity index (PESI) comparing the area under the receiver-operator characteristic curve (AUC) for predicting 30-day mortality. Results We studied 61 patients (56 ±17 years, 44.0% male, 29.5% massive PE, mean PESI 114.6 ± 42.7, mean CART 13.5 ± 1.39, mean eCART 108.5 ± 28.6). Thirty-day mortality was 24.6%. Treatments included rheolytic thrombectomy (32.7%), catheter-directed thrombolysis (50.8%), ultrasound-assisted thrombolysis (32.7%), and mechanical thrombectomy (4.9%). There were no differences in outcome based on technique. The eCART and CART scores had higher AUCs compared to PESI in predicting 30-day mortality (0.84 vs 0.72 vs 0.69, P = .010). We found troponin I and pro-BNP were higher in higher eCART tertiles, however AUCs were 0.51 and 0.63, respectively for 30-day mortality when used as stand-alone predictors. Conclusion Compared to PESI score, CART and eCART scores better predict mortality in massive or submassive PE patients undergoing PMT.
Sphenoid Ridge Meningioma

Nearly all extracerebral, intracranial meningiomas have a common relationship in regard to their blood supply, vascularity, and relationship to neighboring structures. To prevent repetition, only the pertinent operative maneuvers of the specific lesion at hand are shown ; but, if they are taken together with the other chapters dealing with meningiomas, we believe that an exhaustive description is given. Beginning with the tuberculum sellae meningioma, the reader and student should review all chapters presenting the operative handling of meningiomas.
ISOLATION AND CHARACTERIZATION OF A SOYBEAN GENE FOR THE SMALL SUBUNIT OF RIBULOSE-1,5-BISPHOSPHATE CARBOXYLASE

Publisher Summary This chapter discusses an experiment for the isolation and characterization of a soybean gene for the small subunit of ribulose-1,5-bisphosphate carboxylase. Ribulose-1, 5-bisphosphate carboxylase (RuBPcase) catalyzes the fixation of CO 2 via the carboxylation of ribulose-1,5-bisphosphate. It is one of the most abundant proteins in nature. The native protein is composed of two different subunits. The small subunit is encoded by the nucleus, the large subunit by the chloroplast. The mature polypeptide for the small subunit contains 123 amino acids. A cDNA clone for the small subunit of pea RuBPcase contains a major portion of the polypeptide coding sequence. In the experiment, the purified HindIII fragments from the cDNA clone were used to probe the soybean genome for RuBPcase genes.
The Rock and Roll Concert: A Semiotic Analysis

Besides the music and the spectacle, a rock and roll concert involves a fairly distinct pattern of exchanged and exhibited signs. The performance itself, which includes a multitude of signals and implicated meanings, is the focus of the situation. However, persons other than the performers also take part in the situation, and their role in the communication of meanings and exhibition of signs (whether or not fully processed on a given occasion) must be included in any comprehensive semiotic analysis. The inclusion of both audience and performers in this analysis follows the example of Paul Bouissac’s discussion of often constrained role of the spectator in circus performances (1978), Marianne Shapiro’s careful analysis of the performance of a classical ballet (1978), and other studies. It follows also the tradition in semiotic studies of analyzing the interplay of performer, audience, and surrounding situation, as in for example the major work of Roland Barthes (e.g., 1975) and Jan Mukařovský (1977).
A controlled trial of intravenous immune globulin to reduce nosocomial infections in very-low-birth-weight infants

Background Nosocomial infections are a major cause of morbidity and mortality in premature infants. As a rule, their low serum gamma globulin levels at birth subsequently decline to hypogammaglobulinemic values; hence, prophylactic administration of intravenous immune globulin may reduce the rate of hospital-acquired infections. Methods In this prospective, multicenter, two-phase controlled trial, 2416 infants were stratified according to birth weight (501 to 1000 g and 1001 to 1500 g) and randomly assigned to an intravenous immune globulin group (n = 1204) or a control group (n = 1212). Control infants were given placebo infusions during phase 1 of the study (n = 623) but were not given any infusions during phase 2 (n = 589). Infants weighing 501 to 1000 g at birth were given 900 mg of immune globulin per kilogram of body weight, and infants weighing 1001 to 1500 g at birth were given a dose of 700 mg per kilogram. The immune globulin infusions were repeated every 14 days until the infants weighed 1800 g...
The Policy Response to Risk and Risk Perceptions

Virtually every human activity involves a certain amount of risk, from walking downstairs and crossing the street to eating and breathing. Thus, the goal of a risk-free environment is meaningless, unless individuals are willing to cease all activity. We can, however, learn to manage risks more effectively. While some risk management is best conducted by individuals without the involvement of governments, other types of risks require a clear public-policy response.
Individual, Social, and Societal Correlates of Health-Related Quality of Life Among African American Survivors of Ovarian Cancer: Results from the African American Cancer Epidemiology Study.

Abstract Objective: While the incidence of epithelial ovarian cancer (EOC) is lower among African American (AA) women compared with European American (EA) women, AA women have markedly worse outcom...
Moral Judgment and Market Negotiations: A Comparison of Chinese and American Managers:

Given the potential of the trading relationship between the People's Republic of China and the United States, insight into the Sino-American market negotiation process has never been more important...
CBRAM devices based on a nanotube chalcogenide glass structure

CBRAM nano-ionic devices are emerging as a competitive technology solution for transistor free memory, offering low power consumption, fast switching, and non-volatility. However, due to the process by which switching is achieved in these devices, namely stochastic growth of a conductive filament bridging the two electrodes within the amorphous material between the electrodes, they suffer from reliability problems. In this work we present devices built with a nanotube structure of chalcogenide glasses to confine the growing conductive bridge. This structure is found to greatly improve device reliability and switching speed. Furthermore, the technology does not involve additional steps, is cost-effective, and is fully compatible with conventional CMOS technology. We have verified the process of conductive bridge growth with scanning electron microscopy and atom force microscopy and characterized the devices in terms of their current–voltage characteristics, memory window, endurance, and retention, all of which show excellent parameters. Their performance stability is also demonstrated at 130 °C, while multilevel switching is established by application of a variety of compliance currents.
Impact of Gastrointestinal Panel Implementation on Health Care Utilization and Outcomes

PCR-based multiplex gastrointestinal (GI) pathogen panels have started to replace stool culture and ova and parasite exam as a rapid and accurate means of diagnosing acute gastroenteritis. However, there are limited data on the impact of panel testing on patient outcomes. The objective of this study was to evaluate the management and health care utilization of patients following GI panel compared with conventional stool testing. We performed a retrospective comparative analysis of 9,402 patients who underwent testing with the FilmArray GI panel from March 2015 through May 2017 and 5,986 patients who underwent conventional stool testing from December 2012 through February 2015. GI panel was positive in 2,746 exams (29.2%) compared with 246 exams (4.1%) with conventional testing. Within 30 days following stool testing, compared with patients who received a conventional stool test, patients who received a GI panel were less likely to undergo any endoscopic procedure (8.4% GI panel versus 9.6% stool culture, P = 0.008) or any abdominal radiology (29.4% GI panel versus 31.7%, P = 0.002). Within 14 days following stool testing, patients who received a GI panel were less likely to be prescribed any antibiotic (36.2% GI panel versus 40.9%, P < 0.001). The implementation of multiplex PCR stool testing was associated with a reduction in the utilization of endoscopy, abdominal radiology, and antibiotic prescribing.
Increases in a Pro-inflammatory Chemokine, MCP-1, Are Related to Decreases in Memory Over Time.

Objective: To determine the longitudinal relationship between MCP-1/CCL2 and memory function in older adults. Methods: We examined longitudinal plasma MCP-1/CCL2 levels and a longitudinal verbal memory measure (CVLT-II 20’ recall) in a sample of 399 asymptomatic older adults (mean age=72.1). Total visits ranged from 1 to 8, with an average time of 2.1 years between each visit, yielding 932 total observations. In order to isolate change over time, we decomposed MCP-1/CCL2 into subject-specific means and longitudinal deviations from the mean. The decomposed MCP-1/CCL2 variables were entered as predictors in linear mixed effects models, with age at baseline, sex, and education entered as covariates and recall as the longitudinal outcome. In follow-up analyses, we controlled for global cognition and APOE genotype, as well as baseline vascular risk factors. We also examined the specifity of findings by examining the longitudinal association between the MCP-1/CCL2 variables and non-memory cognitive tests. Results: Within-subject increases in MCP-1/CCL2 levels were associated with decreases in delayed recall (t=-2.65; p=.01) over time. Results were independent of global cognitive function and APOE status (t=-2.30, p=.02), and effects remained when controlling for baseline vascular risk factors (t=-1.92, p=.05). No associations were noted between within-subject increases in MCP-1/CCL2 levels and other cognitive domains. Conclusions: In an asymptomatic aging adult cohort, longitudinal increases in MCP-1/CCL2 levels were associated with longitudinal decline in memory. Results suggest that ‘healthy aging’ is typified by early remodeling of the immune system, and that the chemokine, MCP-1/CCL2, may be associated with negative memory outcomes.
An Improved Kalman Filter for Satellite Orbit Predictions

The nonlinear problem of tracking and predicting where a satellite will be over some time can be difficult with the recognition of modeling error and ground site radar tracking errors. For this reason it is important to have an accurate modeling program with the fidelity to correct for any errors in orbital motion and predict the most accurate positioning at some future time. The Extended Kaiman Filter is one such program that can accurately determine position over time given estimate ranges for sources of error. However, the Extended Kaiman Filter contains many linear approximations that allow its prediction and correction methods to work. This paper will discuss the effects of replacing the linearizing approaches made in the orbital model part of the program with numerical small-step approaches. The overall errors during prediction will be compared for an analysis of the corrective ability of the filter. Additionally a final prediction at a later date and another location will serve as an indicator to the usefulness of the prediction capabilities over time. In exploring these effects, it will be shown that the linearizing approximations made in the development are a good approximation to the numerical results. The effects of modeling error, perturbation effects included, and the degree of approximation all play a significant role in accuracies of prediction. The effects of removing linearizations are small in comparison to the effects of perturbations and modeling error. The results of the numerical approximations contain a great robustness and as such help simplify the modeling process. The modeling process is discussed with reference to ADA program code. With these results it can be seen that there are several methods of using the Extended Kaiman Filter for orbital prediction which maintain a high degree of accuracy and can be very useful when applied to real-world satellite prediction.
Between Two Worlds: American New Age Music and Environmental Imaginaries

This article explores how American New Age music imagines the natural world. Through the lens of releases by composers Will Ackerman and Dr. Steven Halpern, I argue that the inherent flexibility and ambiguity of the New Age genre mimics the shifting positions of environmentally-related concepts such as the sublime, the wilderness, and anthropogenic climate change. By exploring two contrasting approaches to the genre, I will outline distinct narratives that provide opposing views of how environmental phenomena function within the New Age context.
T mixing and decay widths of first two 1 − states in B 10

For the isospin-mixed ${1}^{\ensuremath{-}}$ states in $^{10}\mathrm{B}$, widths for deuteron and \ensuremath{\alpha} decays provide an independent estimate of the amount of isospin mixing, which is consistent with results from \ensuremath{\gamma} decays. Analysis provides two solutions for the proton spectroscopic factors of the pure $T=0$ and 1 states.
Abstract 351: A targeted nanocomplex of the IKBKE siRNA inhibits invasiveness and growth of triple negative breast cancer cells

IκB kinase e (IKBKE, or known as IKKe), an important mediator in the activation of NF-κB pathway, was recently identified as an oncogene in breast cancer and overexpressed in approximately 30% of breast carcinomas. It is also highly expressed in TNBC cells, which is correlated with angiogenesis process, high metastasis in NF-κB pathway of TNBC. We found that silencing IKBKE in TNBC cells using siRNA significantly inhibits the proliferation, migration and invasion of TNBC cells by specific silenced 71% of IKBKE in vitro. In vivo study indicated that IKBKE siRNA can inhibit TNBC tumor growth after peritumoral injection at a IKBKE siRNA dose of 0.3 mg/kg. We next developed a CD44-targeting, cholesterol-peptide based nanocomplex to co-deliver the IKBKE siRNA and cabazitaxel to TNBC cells. The nanocomplex showed the synergistic effect of the IKBKE siRNA and cabazitaxel on inhibiting the growth of TNBC tumors in vivo. Modification of the nanocomplex with CD44 further improved tumor uptake and anti-tumor efficacy of the nanocomplex. Our results suggest that IKBKE siRNA is a promising anti-tumor agent for TNBC therapy, and co-delivery of IKBKE siRNA and cabazitaxel using a CD44-targeting nanocomplex is a potential strategy for TNBC treatment. Moreover, this multifunctional delivery system provides a platform for other combination therapy including an siRNA and a chemotherapy drug. Citation Format: Zhen Zhao, Yuanke Li, Kun Cheng. A targeted nanocomplex of the IKBKE siRNA inhibits invasiveness and growth of triple negative breast cancer cells [abstract]. In: Proceedings of the American Association for Cancer Research Annual Meeting 2019; 2019 Mar 29-Apr 3; Atlanta, GA. Philadelphia (PA): AACR; Cancer Res 2019;79(13 Suppl):Abstract nr 351.
The 4-Electron Cleavage of a N=N Double Bond by a Trimetallic TiNi2 Complex

The synthesis and reactivity of a new trimetallic complex Ti(NP)4Ni2 (NP = 2-diphenylphosphinopyrrolide) (3) is reported. Single-crystal X-ray diffraction and X-ray absorption studies point to a un...
Augmented reality-based dance intervention for individuals with Parkinson's disease: A pilot study.

Abstract Background The effects of dance on improving the symptoms of individuals with Parkinson’s disease (PD) is well documented. Augmented reality devices, such as Google Glass, may be used to implement dance interventions to improve mobility and balance. Objective To evaluate the feasibility, safety, and acceptability of a mobile dance intervention and obtain preliminary efficacy estimates for assessment of the research protocol. Methods Seven participants with PD were asked to use Google Glass preloaded with Moving Through Dance modules for three weeks. Changes in motor functions (balance, mobility) and non-motor functions (mood, quality of life) were evaluated before and after completion of the intervention. Results Recruitment rate was 50%, retention rate was 100%, and adherence to usage was 95%. The intervention was safe and accepted by participants. Use of Moving Through Glass improved mobility with a cognitive load (F(1, 5) = 10.76; p Conclusions The outcomes of this pilot study suggest that Moving Through Glass, as a mobile dance intervention, may be a safe way to increase physical activity through dance in individuals with PD. Its efficacy should be investigated in a properly powered randomized controlled trial.
Interlayer separation in hydrogen titanates enables electrochemical proton intercalation

Electrochemical proton intercalation into titanium oxides is typically limited to the near-surface region, necessitating the use of nanostructured high surface area materials to obtain high capacities. Here, we investigate the role of materials structure to extend intercalation beyond the near-surface region. Employing a series of hydrogen titanates (HTOs), we find that electrochemical protonation capacity significantly increases with interlayer structural protonation. The maximum capacity of ∼80 mA h g−1 is achieved with H2Ti3O7, which also undergoes reversible structural and optical changes during the de/intercalation process. Using quasi-elastic neutron scattering, we show that structural protons are highly confined in the HTO interlayer with only localized, but not translational, dynamics. Electrochemical protonation leads to a contraction of the H2Ti3O7 interlayer without causing significant strain in the two-dimensional titanate layers. Density functional theory calculations indicate more favorable adsorption energy for intercalated protons in H2Ti3O7 as compared to HTOs with fewer structural protons. We hypothesize that interlayer structural protons are the structural feature responsible for the high electrochemical protonation capacity in H2Ti3O7 because they effectively decrease the interconnections between the titanate layers. This enables facile compensation of the electrochemically introduced strain via one-dimensional interlayer contraction. These results demonstrate the special structural requirements for bulk proton intercalation in titanium oxides, and offer a new materials design strategy for high energy density aqueous energy storage.
A Deep-Reinforcement-Learning-Based Approach to Dynamic eMBB/URLLC Multiplexing in 5G NR

This article investigates the dynamic multiplexing of enhanced mobile broadband (eMBB) and ultrareliable and low latency communications (URLLC) on the same channel in 5G NR. Due to significant difference in transmission time scale, URLLC employs a preemptive puncturing technique to multiplex its traffic onto eMBB traffic for transmission. The optimization problem to solve is to minimize the adverse impact of such preemptive puncturing on eMBB users. We present DEMUX—a model-free deep reinforcement learning (DRL)-based solution to this problem. The essence of DEMUX is to use deep function approximators (neural networks) to learn an optimal algorithm for determining the preemption solution in each eMBB transmission time interval (TTI). Our novel contributions in the design of DEMUX include the first use of the DRL method with a large and continuous action domain for resource scheduling in NR, a mechanism to ensure fast and stable learning convergence by exploiting the intrinsic properties of the problem, and a mechanism to obtain a feasible preemption solution from the unconstrained output of a neural network while minimizing loss of information. The experimental results show that DEMUX significantly outperforms state-of-the-art algorithms proposed in the 3GPP standards body and the literature.
Gastroparesis and Severity of Delayed Gastric Emptying: Comparison of Patient Characteristics, Treatments and Medication Adverse Events.

Gastroparesis is a heterogeneous disorder. Patient characteristics and treatment responsiveness may differ based on the extent of delay in gastric emptying. Characterize gastroparesis patients based on the degree of delay in gastric emptying, and assess the relationship of patient demographics, symptoms and response to therapy based on the extent of delay. 1333 solid-phase 4-h scintigraphic gastric emptying scans were reviewed. Delayed emptying was categorized on percent retention at 4 h: mild (10–19%), moderate (20–29%), and severe (≥ 30%). Analyses were performed with regard to demographics, symptoms, esophagogastroduodenoscopy findings, medication use, and emergency department (ED) visits/hospitalizations. 284 patients had delayed gastric emptying: mild (42.6%), moderate (19.3%), and severe (37.3%). 79.5% were women, the mean age was 45 years (± 15), and mean symptom duration was 4.6 years (± 6.5). The main categories of gastroparesis were idiopathic and diabetes mellitus. The most commonly prescribed medications were metoclopramide, domperidone and erythromycin. Opiate use (n = 69) was associated with an increased degree of delayed gastric emptying (p = 0.03) with 50% of opiate users having very delayed gastric emptying. One-way analysis revealed that severely delayed gastric emptying correlated with both increased hospitalizations and ED visits. Severe delay in gastric emptying is a risk factor for increased hospitalizations and ED visits. Opiate use correlates with increased severity of gastric emptying. Identifying at-risk patients, stopping opioids, and instituting a programmatic care plan for patients with severely delayed gastric emptying may reduce ED visits, hospitalizations, and healthcare costs.