cssi/SciSciGPT-SciSciNet huggingface dataset:
Integration of multi-omics data for integrative gene regulatory network inference

Gene regulatory networks provide comprehensive insights and indepth understanding of complex biological processes. The molecular interactions of gene regulatory networks are inferred from a single type of genomic data, e.g., gene expression data in most research. However, gene expression is a product of sequential interactions of multiple biological processes, such as DNA sequence variations, copy number variations, histone modifications, transcription factors, and DNA methylations. The recent rapid advances of high-throughput omics technologies enable one to measure multiple types of omics data, called 'multi-omics data', that represent the various biological processes. In this paper, we propose an Integrative Gene Regulatory Network inference method (iGRN) that incorporates multi-omics data and their interactions in gene regulatory networks. In addition to gene expressions, copy number variations and DNA methylations were considered for multi-omics data in this paper. The intensive experiments were carried out with simulation data, where iGRN's capability that infers the integrative gene regulatory network is assessed. Through the experiments, iGRN shows its better performance on model representation and interpretation than other integrative methods in gene regulatory network inference. iGRN was also applied to a human brain dataset of psychiatric disorders, and the biological network of psychiatric disorders was analysed.
Hemispheric Cerebral Oximetry Monitoring During Pediatric Seizure Activity in a Pediatric Emergency Department.

BACKGROUND Sustained neuronal activity during seizures causes cellular perturbations, alterations in cerebral physiology, and potentially neurological injury, a neurological emergency. With variable clinical manifestations of seizures, frequent failure of seizure recognition by providers in pediatric and developmentally challenged patients can increase seizure complications. Neuroresuscitation should include rapid cerebral physiology assessment for increased seizure recognition and optimal neurological outcomes. In neurological emergencies, cerebral oximetry has demonstrated its utility in altered cerebral physiology and a standard combat neurological assessment tool. During adult seizures, cerebral oximetry (regional cerebral oxygen saturation [rcSO2]) has been shown as a useful neurological assessment tool, but research is lacking in pediatric emergency department (PED) seizure patients. OBJECTIVE The aim of this study was to identify trends in rcSO2 readings for patients presenting to the PED with seizure activity and in the postseizure state in order to evaluate usefulness of rcSO2 as a neurological assessment tool in pediatric seizure patients. METHODS This was a PED observational case series comparing hemispheric rcSO2 readings in first-time clinically evident generalized and focal seizure patients to first-time postseizure patients with no PED seizures. RESULTS Generalized or focal seizure (n = 185) hemispheric rcSO2 revealed significant differences compared with nonseizure and controls' rcSO2 readings (n = 115) (P < 0.0001). Generalized and focal seizure rcSO2's were either less than 60% or greater than 80% compared with nonseizure rcSO2 (P < 0.0001). Ipsilateral focal seizure rcSO2 correlated to seizure side (P < 0.0001) and was less than the contralateral rcSO2 (P < 0.0001), with interhemispheric rcSO2 discordance greater than 16 (P < 0.0001). Seizure to preseizure rcSO2 discordance was as follows: generalized 15.2, focal: left 19.8, right 20.3 (P < 0.0001). CONCLUSIONS Hemispheric during-seizure rcSO2 readings significantly correlated with generalized and focal seizures and reflected altered cerebral physiology. Ipsilateral focal seizure rcSO2 readings correlated to the focal side with wide interhemispheric rcSO2 discordance. All postseizure rcSO2 readings returned to preseizure readings, showing altered cerebral physiology resolution. Overall, in generalized or focal seizure, rcSO2 readings were less than 60% or greater than 80%, and in focal seizure, interhemispheric rcSO2 discordance was greater than 10. During seizures, hemispheric rcSO2 readings demonstrated its potential pediatric seizure utility. Utilizing rcSO2 readings related to seizure activity could expedite pediatric and developmentally challenged patients' seizure recognition, cerebral assessment, and interventions especially in pharmacoresistant seizures.
A Challenging Blastic Plasmacytoid Dendritic Cell Neoplasm Case: Tough Decisions to Make.

Blastic plasmacytoid dendritic cell neoplasm is a very rare disease and in our case report we discuss the presentation of our patient, her treatment and response in addition for a discussion of the newly therapeutic options that are available. J Hematol. 2018;7(1):19-22 doi: https://doi.org/10.14740/jh355w
Implantation Depth and Rotational Orientation Effect on Valve-in-Valve Hemodynamics and Sinus Flow.

Background This study evaluated the effect of transcatheter aortic valve implantation depth and rotation on pressure gradient (PG), leakage fractions (LF), leaflet shear stress, and sinus washout in an effort to understand factors that may dictate optimal positioning for valve-in-valve (ViV) procedures. Sinus flow stasis is often associated with prosthetic leaflet thrombosis. Although recent ViV in vitro studies highlighted potential benefits of transcatheter aortic valve supraannular implantation to minimize PGs, the relationship between transcatheter aortic valve depth and other determinates of valve function remains unknown. Among these, LFs, shear stress, and poor sinus washout have been associated with poorer valve outcomes. Methods ViV hemodynamic performance was evaluated in vitro vs axial positions –9.8, –6.2, 0, and +6 mm and angular orientations 0, 30, 60, and 90 degrees in a degenerated surgical aortic valve. PGs, LFs, and sinus shear stress and washout were compared. Leaflet high-speed imaging and particle-image velocimetry were performed to elucidate hemodynamic mechanisms. Results (1) The PG varies as a function of axial position, with supraannular deployments yielding a maximum benefit of 7.85 mm Hg less than PGs for subannular deployments irrespective of commissural alignment (p Conclusions First, supraannular axial deployment is associated with lower PGs irrespective of commissural alignment. Second, subannular deployment is associated with more favorable sinus hemodynamics and less LF. Further in vivo studies are needed to substantiate these observations and facilitate optimal prosthesis positioning during ViV procedures.
Information-seeking behavior and information providers in a K’iche’ Maya community: An ethnographic study of Nahualá, Guatemala

The study investigated the information-seeking behavior and information provision practices among bilingual (Spanish and K’iche’) students and adults in a Maya town in highland Guatemala. The resea...
Consequences of Grafting Density on the Linear Viscoelastic Behavior of Graft Polymers

The linear viscoelastic behavior of poly(norbornene)-graft-poly(±-lactide) was investigated as a function of grafting density and overall molar mass. Eight sets of polymers with grafting densities ranging from 0 to 100% were synthesized by living ring-opening metathesis copolymerization. Within each set, the graft chain molar mass and spacing between grafts were fixed, while the total backbone length was varied. Dynamic master curves reveal that these polymers display Rouse and reptation dynamics with a sharp transition in the zero-shear viscosity data, demonstrating that grafting density strongly impacts the entanglement molar mass. The entanglement modulus (Ge) scales with inverse grafting density (ng) as Ge ∼ ng1.2 and Ge ∼ ng0 in accordance with scaling theory in the high and low grafting density limits, respectively. However, a sharp transition between these limiting behaviors occurs, which does not conform to existing theoretical models for graft polymers. A molecular interpretation based on thin fl...
Suicidal ideation and behavior in US veterans with schizophrenia or bipolar disorder.

Abstract Objective Using data from a Department of Veterans Affairs study of schizophrenia (SZ) and bipolar I disorder (BP), we evaluated lifetime risks for suicidal ideation and behavior. We were interested in the prevalence and correlates of these outcomes, in populations of patients with severe mental illness (SMI), who have not been compared directly in previous studies despite data on high risk in each group separately. Method Data were collected on demographic factors, medical and psychiatric comorbidity, cognitive and functional status, and lifetime suicidal ideation or behavior in a study of veterans with SZ (N = 3942) or BP (N = 5414). In-person diagnosis and evaluation, including performance-based assessments of cognition and functional skills, make this study unique compared to studies of completed suicide. Multinomial logistic regression examined how risk factors, including major depression and negative symptoms in SCZ patients, correlated with ideation and behavior. Results A lifetime history of suicidal ideation or behavior was reported by a majority of Veterans with SZ (69.9%) or BP (82.3%). Lower risk was found for patients with SZ vs. BP (odds ratio [OR] = 0.82 for ideation; OR = 0.81 for behavior). The highest risk was found for patients with multiple psychiatric comorbidities (OR = 2.61 for ideation; OR = 3.82 for behavior). Clinical factors (e.g., psychiatric comorbidity) contributed more of the variance in the predictive model than demographic factors. Conclusions A history of suicidal ideation or behavior is common among US Veterans with SZ or BP, and specific demographic and clinical attributes correlate with variation in risk. These findings underscore the need for continuous monitoring for suicidal ideation and behavior in veteran populations with SMI, as well as the development of better risk predictions, including genomic factors. Although PTSD is a major current focus in veteran populations, the large number of veterans with SZ or BP and their high suicide risk suggests a greater clinical focus may be warranted.
Electrocatalytic and photocatalytic hydrogen evolution integrated with organic oxidation

Renewable energy-driven hydrogen production from electrocatalytic and photocatalytic water splitting has been widely recognized as a promising approach to utilize green energy resources and hence reduces our dependence on legacy fossil fuels as well as alleviates net carbon dioxide emissions. The realization of large-scale water splitting, however, is mainly impeded by its slow kinetics, particularly because of its sluggish anodic half reaction, the oxygen evolution reaction (OER), whose product O2 is ironically not of high value. In fact, the co-production of H2 and O2 in conventional water electrolysis may result in the formation of explosive H2/O2 gas mixtures due to gas crossover and reactive oxygen species (ROS); both pose safety concerns and shorten the lifetimes of water splitting cells. With these considerations in mind, replacing the OER with thermodynamically more favorable organic oxidation reactions is much more preferred, which will not only substantially reduce the voltage input for H2 evolution from water and avoid the generation of H2/O2 gas mixtures and ROS, but also possibly lead to the co-production of value-added organic products on the anode. Indeed, such an innovative strategy for H2 production integrated with valuable organic oxidation has attracted increasing attention in both electrocatalysis and photocatalysis. This feature article showcases the most recent examples along this endeavor. As exemplified in the main text, the oxidative transformation of a variety of organic substrates, including alcohols, ammonia, urea, hydrazine, and biomass-derived intermediate chemicals, can be integrated with energy-efficient H2 evolution. We specifically highlight the importance of oxidative biomass valorization coupled with H2 production, as biomass is the only green carbon source whose scale is comparable to fossil fuels. Finally, the remaining challenges and future opportunities are also discussed.
Filling the Gap: Creating an Outpatient Palliative Care Program in Your Institution

Well-designed, randomized trials demonstrate that outpatient palliative care improves symptom burden and quality of life (QOL) while it reduces unnecessary health care use in patients with cancer. Despite the strong evidence of benefit and ASCO recommendations, implementation of outpatient palliative care, especially in community oncology settings, faces considerable hurdles. This article, which is based on published literature and expert opinion, presents practical strategies to help oncologists make a strong clinical and fiscal case for outpatient palliative care. This article outlines key considerations for how to build an outpatient palliative care program in an institution by (1) defining the scope and benefits; (2) identifying strategies to overcome common barriers to integration of outpatient palliative care into cancer care; (3) outlining a business case; (4) describing successful models of outpatient palliative care; and (5) examining important factors in design and operation of a palliative care...
Biological Control Potentials Of Predatory Nematodes

Biological control potential of predatory nematodes is evaluated and discussed in the following chapter. Attributes of a successful biological control agent such as mass production, reproductive potential, longevity, compatibility with agrochemicals, safety to non-target organisms, prey search ability, environmental adaptability, dispersal and persistence capabilities etc., are enumerated. Prey searching and feeding mechanisms, prey preferences, ecology, biology and conservation of predatory nematodes and prey resistance and susceptibility to predation are elaborated and supplemented with the list of plant-parasitic nematodes recorded as prey to various species of predatory nematodes.
Modeling Frog and Toad Depth Perception

In this chapter we review the reasons why previous theoretical models do not provide an adequate explanation for the depth perception process in frogs and toads. We begin with a survey of earlier depth models and a review of experimental evidence from behavioral, anatomical, and physiological experiments relating to depth perception in frogs and toads. We conclude by contrasting the assumptions made in the models with observations about the animals. We note that all of the previous depth models based on stereopsis are restricted to the consideration of binocular matching on a pair of static images, and that their purpose is to produce a depth-mapping from the image pair. These models also depend upon assumptions concerning vergence and image granularity. We show that these restrictions and assumptions are not applicable to the depth resolution problem in frogs and toads.
Bio-inspired ultrasensitive colorimetric detection of methyl isothiocyanate on nylon-6 nanofibrous membrane: A comparison of biological thiol reactivities

Abstract Living organisms, including human beings, rapidly show skin color changes after chemical poisonings, a result of toxicological or detoxification reactions caused by biological thiol compounds. On the other side, quick and portable detection of highly-volatile toxicants is an urgent need for improving human safety and personal protection, especially real-time monitoring of fumigants at low level for protection of farm workers and residents from overexposure of fumigants, vaporous pesticides. Here, we designed a rapid and portable detection method for methyl isothiocyanate (MITC) vapor by mimicking detoxification reactions of biological thiols in human bodies with MITC. The detection reaction was implemented on a nylon-6 nanofibrous membrane with ultrahigh surface areas to show color signals with the addition of Ellman’s reagent. The reactivities of glutathione, N-acetyl-L-cysteine, L-homocysteine, cysteamine, and thioglycolic acid toward MITC were experimentally explored and theoretically discussed. The detection sensitivity is tunable in different biological thiol systems, which broadens the sensor applications in detection of trace amount of MITC in ambient environment and improves the protection of human safety. The new sensor system reduced the sensor operation time to 15 min and achieved the detection limit of 99 ppb, much lower than its permissible exposure limit (220 ppb).
Rsp5 Ubiquitin ligase-mediated quality control system clears membrane proteins mistargeted to the vacuole membrane.

Maintenance of organelle identity is profoundly dependent on the coordination between correct targeting of proteins and removal of mistargeted and damaged proteins. This task is mediated by organelle-specific protein quality control (QC) systems. In yeast, the endocytosis and QC of most plasma membrane (PM) proteins requires the Rsp5 ubiquitin ligase and ART adaptor network. We show that intracellular adaptors of Rsp5, Ear1, and Ssh4 mediate recognition and vacuolar degradation of PM proteins that escape or bypass PM QC systems. This second tier of surveillance helps to maintain cell integrity upon heat stress and protects from proteotoxicity. To understand the mechanism of the recognition of aberrant PM cargos by Ssh4–Rsp5, we mistarget multiple PM proteins de novo to the vacuolar membrane. We found that Ssh4–Rsp5 can target and ubiquitinate multiple lysines within a restricted distance from the membrane, providing a fail-safe mechanism for a diverse cargo repertoire. The mistargeting or misfolding of PM proteins likely exposes these lysines or shifts them into the “ubiquitination zone” accessible to the Ssh4–Rsp5 complex.
News stories framed episodically offer more diversified portrayals of immigrants

This study investigated the representations of immigrants emerging from frames used in news stories in the two largest-circulation daily newspapers in Arizona: The Arizona Republic and the Arizona ...
Towards a genome-based virus taxonomy.

Complementary genomic frameworks for taxonomic classification of viruses infecting bacteria and archaea reveal evolutionary drivers, mosaicism and perspective on the genetic diversity of the tiniest, most abundant biological entities on Earth.
PROTEIN SELF-MARKING BY EMERALD ASH BORER: AN EVALUATION OF EFFICACY AND PERSISTENCE

Understanding the dispersal ability of invasive insects provides useful insights for developing effective management strategies. Historically, methods for marking insects for dispersal studies have been expensive, time-consuming, and labor-intensive, especially for woodboring beetles. In addition, capturing or rearing insects requires human handling, which can alter behavior. Immunomarking is a well-established technique for studying the dispersal of insects, however, it has not been broadly applied to woodborers. This study evaluates the potential for using immunoproteins applied directly to woodborer-infested trees to mark emerging beetles. Specifically, in the first experiment I sprayed varying concentrations of ovalbumin (egg white) solution directly onto logs infested with emerald ash borer (EAB, Agrilus planipennis Fairmaire) (Buprestidae: Agrilini) and ELISA was used to detect the presence of protein on emerged beetles. To test the persistence of the mark, I applied varying concentrations of albumin to freeze-killed beetles, mounted them on pins, and placed them in an exposed location outdoors. Adult EAB self-marked as they emerged from protein-treated trees, with higher protein concentrations persisting for longer on the cuticle when exposed to sun and rain. This technique offers a convenient, inexpensive and durable means of marking woodborers and circumvents the need for human handling, allowing for more natural behavior and more realistic estimates of dispersal. Protein self-marking may find application in studies of woodborer dispersal within natural forest environments.
Regular physical activity reduces the percentage of spinally projecting neurons that express mu-opioid receptors from the RVM

Regular physical activity/exercise is an effective non-pharmacological treatment for individuals with chronic pain. Central inhibitory mechanisms, involving serotonin and opioids, are critical to analgesia produced by regular physical activity. The RVM sends projections to the spinal cord to inhibit or facilitate nociceptive neurons and plays a key role in exercise-induced analgesia. The goal of these studies was to examine if regular physical activity modifies RVM-spinal cord circuitry. Male and female mice received Fluoro-Gold placed on the spinal cord to identify spinally projecting neurons from the rostral ventromedial medulla (RVM) and the nucleus raphe obscuris/nucleus raphe pallidus (NRO/NRP), dermorphin-488 into caudal medulla to identify mu-opioid receptors, and were immunohistochemically stained for either phosphorylated-N-methyl-D-aspartate subunit NR1 (p-NR1) to identify excitatory neurons or tryptophan hydroxylase (TPH) to identify serotonin neurons. The percentage of dermorphin-488-positive cells that stained for p-NR1 (or TPH), and the percentage of dermorphin-488-positive cells that stained for p-NR1 (or TPH) and Fluoro-Gold was calculated. Physically active animals were provided running wheels in their cages for 8 weeks and compared to sedentary animals without running wheels. Animals with chronic muscle pain, induced by two intramuscular injections of pH 4.0, were compared to sham controls (pH 7.2). Physically active animals had less mu-opioid expressing neurons projecting to the spinal cord when compared to sedentary animals in the RVM, but not the NRO/NRP. No changes were observed for TPH. These data suggest that regular exercise alters central facilitation so that there is less descending facilitation to result in a net increase in inhibition.
M&M: Deep learning aided multi-facet mental health support tool for College Students

College students are experiencing increasing rates of depression, anxiety and other mental health disorders. However, traditional face-to-face consultations are not always accessible, and the current digital interventions cannot provide the richness of an in-person consultation. To address such problems, we developed a smartphone application called Mental Mentor (M&M) to help college students cope with their anxieties especially those related to their academic performance. M&M application applies a retrieval-based model to provide academic mentoring advice and a deep learning-based model for emotional support. Results show that our M&M not only provides effective responses for emotional support but is also helpful with students' academic coaching.
$p$-permutation equivalences between blocks of group algebras

We extend the notion of a {$p$-permutation equivalence} between two $p$-blocks $A$ and $B$ of finite groups $G$ and $H$, from the definition in [Boltje-Xu 2008] to a virtual $p$-permutation bimodule whose components have twisted diagonal vertices. It is shown that various invariants of $A$ and $B$ are preserved, including defect groups, fusion systems, and Kulshammer-Puig classes. Moreover it is shown that $p$-permutation equivalences have additional surprising properties. They have only one constituent with maximal vertex and the set of $p$-permutation equivalences between $A$ and $B$ is finite (possibly empty). The paper uses new methods: a consequent use of module structures on subgroups of $G\times H$ arising from Brauer constructions which in general are not direct product subgroups, the necessary adaptation of the notion of tensor products between bimodules, and a general formula (stated in these new terms) for the Brauer construction of a tensor product of $p$-permutation bimodules.
Superior Capsule Reconstruction: A Glimpse into the Future?:

The recent study by Mihata et al., [10] “Five-year follow-up of arthroscopic superior capsule reconstruction for irreparable rotator cuff tears” (J Bone Joint Surg Am. 2019;101:1921–1930), was the ...
A Case of Severe Refractory Pemphigus Vulgaris in a Patient With Stable Esophageal Malignancy.

Pemphigus is a broad term that is used to describe a group of bullous autoimmune diseases affecting the skin and mucous membranes; the pathogenesis involves autoantibodies directed against various cell junction desmosomal proteins. In patients with a history of malignancy who present with bullous lesions, the differential diagnosis may include, but is not limited to, paraneoplastic pemphigus (PNP) and pemphigus vulgaris (PV) secondary to a primary autoimmune process, or induced by chemotherapy or radiation therapy. In this report, we present a case of refractory PV in a patient with stable esophageal cancer, five years after undergoing radiation therapy. He was poorly responsive to corticosteroids and intravenous immunoglobulin (IVIG). PNP or PV in a patient with stable esophageal malignancy has not been previously reported. PNP and PV can have overlapping autoantigens [desmoglein types 1 and 3 (DSG1 and DSG3)] as well as similar presentations. Thus, distinguishing between the two may be challenging in a patient with a history of cancer. More research must be done to determine if PNP can be seen in a patient with stable esophageal malignancy and, similarly, if PV can be precipitated by stable esophageal malignancy. Such research would aid in determining whether or not similar presentations are more severe or refractory to standard treatment regimens, thereby contributing to improve treatment strategies.
A Social Media Study on Demographic Differences in Perceived Job Satisfaction

Effective ways to measure employee job satisfaction are fraught with problems of scale, misrepresentation, and timeliness. Current methodologies are limited in capturing subjective differences in expectations, needs, and values at work, and they do not lay emphasis on demographic differences, which may impact people's perceptions of job satisfaction. This study proposes an approach to assess job satisfaction by leveraging large-scale social media data. Starting with an initial Twitter dataset of 1.5M posts, we examine two facets of job satisfaction, pay and supervision. By adopting a theory-driven approach, we first build machine learning classifiers to assess perceived job satisfaction with an average AUC of 0.84. We then study demographic differences in perceived job satisfaction by geography, sex, and race in the U.S. For geography, we find that job satisfaction on Twitter exhibits insightful relationships with macroeconomic indicators such as financial wellbeing and unemployment rates. For sex and race, we find that females express greater pay satisfaction but lower supervision satisfaction than males, whereas Whites express the least pay and supervision satisfaction. Unpacking linguistic differences, we find contrasts in different groups' underlying priorities and concerns, e.g., under-represented groups saliently express about basic livelihood, whereas the majority groups saliently express about self-actualization. We discuss the role of frame of reference and the "job satisfaction paradox", conceptualized by organizational psychologists, in explaining our observed differences. We conclude with theoretical and sociotechnical implications of our work for understanding and improving worker wellbeing.
Philosophy of Psychiatry

Jonathan Y. Tsou examines and defends positions on central issues in philosophy of psychiatry. The positions defended assume a naturalistic and realist perspective and are framed against skeptical perspectives on biological psychiatry. Issues addressed include the reality of mental disorders; mechanistic and disease explanations of abnormal behavior; definitions of mental disorder; natural and artificial kinds in psychiatry; biological essentialism and the projectability of psychiatric categories; looping effects and the stability of mental disorders; psychiatric classification; and the validity of the DSM's diagnostic categories. The main argument defended by Tsou is that genuine mental disorders are biological kinds with harmful effects. This argument opposes the dogma that mental disorders are necessarily diseases (or pathological conditions) that result from biological dysfunction. Tsou contends that the broader ideal of biological kinds offers a more promising and empirically ascertainable naturalistic standard for assessing the reality of mental disorders and the validity of psychiatric categories.
Mechanisms of Macrophage Plasticity in the Tumor Environment: Manipulating Activation State to Improve Outcomes.

Macrophages are a specialized class of innate immune cells with multifaceted roles in modulation of the inflammatory response, homeostasis, and wound healing. While developmentally derived or originating from circulating monocytes, naive macrophages can adopt a spectrum of context-dependent activation states ranging from pro-inflammatory (classically activated, M1) to pro-wound healing (alternatively activated, M2). Tumors are known to exploit macrophage polarization states to foster a tumor-permissive milieu, particularly by skewing macrophages toward a pro-tumor (M2) phenotype. These pro-tumoral macrophages can support cancer progression by several mechanisms including immune suppression, growth factor production, promotion of angiogenesis and tissue remodeling. By preventing the adoption of this pro-tumor phenotype or reprogramming these macrophages to a more pro-inflammatory state, it may be possible to inhibit tumor growth. Here, we describe types of tumor-derived signaling that facilitate macrophage reprogramming, including paracrine signaling and activation of innate immune checkpoints. We also describe intervention strategies targeting macrophage plasticity to limit disease progression and address their implications in cancer chemo- and immunotherapy.
Human-Robot Interactions Design for Interview Process: Needs-Affordances-Features Perspective

Human robot interaction (HRI) offers potential in fulfilling the social needs of humans specifically, in the context of an interview setting. While human robot interaction has proven potentials to provide relatively measurable outcomes in experimentation, applications in real life are limited mainly due to primitive HRI design and implementation. Research in HRI is thus the necessary first step to the diffusion of robots and robotic technologies into social life. This study presents the results a case study on HRI design for a formal interview process. The findings are presented in a framework that elucidates the key expected robot affordances—action possibilities afforded by a humanoid robot—and their relationships with humans in the interactive interview context. This framework development has been informed by the Needs-Affordances-Features perspective.
Stressors and Other Pandemic-related Predictors of Prospective Changes in Psychological Distress.

Abstract Background Numerous studies have documented mental health challenges during the COVID-19 pandemic. Few studies included pre-pandemic levels of mental health or were comprehensive in assessing factors likely associated with longer-term mental health impacts. Methods Analyses used prospective data from a subset of participants in the nationwide Cancer Prevention Study-3 (CPS-3) United States cohort (N=2,359; 1,534 women; 825 men) who completed surveys in 2018 and during the COVID-19 pandemic (July-September 2020). Logistic regressions examined associations of pandemic-related stressors, sociodemographic and other predictors with (i) overall psychological distress (PD) and depression and anxiety separately during the COVID-19 pandemic and (ii) change in PD from 2018 to during the pandemic (low/low; high to low; low to high; high/high). Findings During the pandemic, 10% of participants reported moderate-to-severe PD and almost half (42%) reported at least mild PD. Pandemic PD levels were associated with pre-pandemic PD (female OR=5.65; male OR=9.70), financial stressors (female OR=2.48; male OR=3.68), and work/life balance stressors (female OR=3.03; male OR=3.33) experienced since the pandemic began. These stressors also predicted an escalation from low PD in 2018 to high PD during the pandemic. Factors associated with high PD at both time points included younger age, female sex, and financial stressors. Interpretation These results highlight the importance of regular mental health assessment and support among those with a history of mental health problems and those experiencing pandemic-related stressors, such as those with caregiving responsibilities or job changes. Funding The American Cancer Society funds the creation, maintenance, and updating of the CPS-3.
Effective Local Geometry Descriptor for 29Si NMR Q4 Anisotropy

Author(s): Venetos, MC; Dwaraknath, S; Persson, KA | Abstract: The nuclear shielding anisotropy, ζ, is a useful nuclear magnetic resonance (NMR) shielding tensor parameter in describing the extent of electron cloud distortion about an atom. Despite the advantages afforded by NMR in structural characterization, the relationship between ζ and local structure of an atom in high-symmetry environments, such as Si-Q4sites, is poorly understood. Here, we use a data-driven approach combining random forest feature ranking and the Sure Independence Screening and Sparsifying Operator (SISSO) approach to derive a simple and accurate geometric descriptor for ζ with a root-mean-squared prediction error of 6.77 ppm and anR2of 0.761. We then apply this descriptor to describe the local geometric distortion of zeolites Sigma-2 and silica-ZSM-5 whose chemical shift anisotropy tensor has been reported. We envision that this geometric descriptor will allow for structural description and refinement in previously difficult-to-describe materials.
Propulsion Diagnostic Method Evaluation Strategy (Prodimes) User's Guide

This report is a User's Guide for the Propulsion Diagnostic Method Evaluation Strategy (ProDiMES). ProDiMES is a standard benchmarking problem and a set of evaluation metrics to enable the comparison of candidate aircraft engine gas path diagnostic methods. This Matlab (The Mathworks, Inc.) based software tool enables users to independently develop and evaluate diagnostic methods. Additionally, a set of blind test case data is also distributed as part of the software. This will enable the side-by-side comparison of diagnostic approaches developed by multiple users. The Users Guide describes the various components of ProDiMES, and provides instructions for the installation and operation of the tool.
“On the System of Stravinsky’s Harmony” by Yuri Kholopov: Translation and Commentary

ABSTRACT: Yuri Kholopov is generally regarded as the foremost Russian music theorist in the latter half of the twentieth century. Though he published articles in a wide array of topics, he was happiest when discussing twentieth-century concepts; it was to this end that he devoted a large part of his life’s work. The essay by Kholopov translated in the present article is from 1997, six years before he died. There are several significant points that he makes with respect to Stravinsky’s music. First, Kholopov links a quotation from Stravinsky on harmony to Sergei Taneev’s Invertible Counterpoint in the Strict Style, thus suggesting that by borrowing ideas from Taneev, the Petersburg-based Stravinsky was influenced by the Moscow-based Taneev. This speaks to a possible Russian influence on Stravinsky aside from Rimsky-Korsakov, whose influence on Stravinsky is not in doubt. Second, Kholopov posits a new fundamental “neotonality” in Stravinsky’s music, which exhibits a “central element” (CE) to which all other tones gravitate. Third, Kholopov’s work situates octatonicism into a broader framework of Stravinsky’s compositional practices. Ultimately, it is but one aspect of this music and is not emphasized as a fundamental structural element in Stravinsky’s music, as it is in writings by Arthur Berger, Pieter van den Toorn, and Richard Taruskin, for example. Fourth, in the section on polarity, Kholopov posits that when Stravinsky uses this term in relation to his music, he may have meant to say “stability,” which was a term from the writings of Boleslav Yavorsky that most Russian musicians knew in the early twentieth century. This reinterpretation of polarity sheds new light on this most important concept in Stravinsky studies. Lastly, there is the idea that Stravinsky was, in fact, a serial composer for his entire life. Of course, Stravinsky famously claimed so himself late in life; Kholopov solidifies this claim, traces the evolution of Stravinsky’s serial works, and finds an intriguing four-note series in Firebird.
Child protection: A 50‐year perspective

It has been 50 years since Kempe et al. published 'The Battered Child Syndrome', describing harm from inflicted injury mechanisms derived from parents and care givers. Since then, there has emerged a rapidly expanding literature on paediatric forensic medicine and child protection, which has offered new insights into injury mechanisms, informed us of the sequelae of abuse and neglect, aided diagnosis and guided clinical practice in the treatment and management of children who become involved in the child protection system. Through the scrutiny of government inquiries and at times uncomfortable media exposure, there have been improvements in child protection and forensic practices resulting in recognition of need for specialised forensic training, improved funding, development of resources and development of professional standards that support accountable, objective, safe and robust practice. From the perspective of an Australian child protection paediatrician, this paper chronicles some of the most significant and at times controversial research in the last 50 years in child protection that have played a key role in shaping our current understanding of child abuse and neglect.
Rate-limited plastic deformation in nanocrystalline Ni

Numerical simulations at nanometer scales have identified several mechanisms of plastic deformation. However, high strain rate regimes are required to resolve nanometer length scales. Extrapolating these numerical predictions at high strain rates to experimental conditions remains an unresolved challenge. Phase-field dislocation dynamics (PFDD) simulations are conducted to study the strain rate sensitivity of plastic deformation in nanocrystalline metals. The PFDD simulations involve the collective behavior of partial and extended full dislocations at strain rates ranging from 1 × 106 s−1 to 1 × 109 s−1 in Ni samples with an average grain size of 15 nm. Significant differences are found in the activation and glide of dislocations over this range of strain rates. At high strain rates, there are a large number of partial dislocations that begin to glide at grain boundaries across the entire sample. On the other hand, glide events are limited to a few grain boundaries at lower strain rates. Even though, the number of events is larger at high strain rates, mainly leading partial dislocations are active, and therefore, the amount of plastic deformation is smaller. This leads to an effective delay in plastic strain at high strain rates that explain the stress upturn observed at high strain rates when plastic deformation is carried out by partial dislocations. When extended full dislocations are present at lower strain rates, the yield stress is reduced by around 40%.
Detection of African horse sickness virus by reverse transcription-PCR.

Reverse transcription-PCR (RT-PCR) was used to detect African horse sickness virus (AHSV). A single primer pair which amplified a 423-bp fragment of the S8 gene which encodes the NS2 protein of AHSV was identified. Amplification of this fragment from all nine serotypes of AHSV was achieved with these primers. Between 10(1) and 10(2) copies of AHSV genomic double-stranded RNA could be detected by RT-PCR followed by agarose gel electrophoresis and ethidium bromide staining. Application of RT-PCR to blood samples from AHSV-infected horses resulted in earlier detection of viremia than virus isolation did. Furthermore, viremia was detected by RT-PCR in blood samples from horses infected with an avirulent isolate of AHSV which were negative by virus isolation. AHSV was also detected by RT-PCR in spleen and lung samples from horses which died of AHSV infection. These results indicate that RT-PCR is a rapid and sensitive method for the identification of horses infected with AHSV. Images
New full-diversity high-rate space-time block codes based on selective power scaling

We design a new rate-5 over 4 full-diversity orthogonal STBC for QPSK and 2 transmit antennas by enlarging the signalling set from the set of quaternions used in the Alamouti [1] code. Selective power scaling of information symbols is used to guarantee full-diversity while maximizing the coding gain and minimizing the transmitted signal peak-to-minimum power ratio. The optimum power scaling factor is derived using two equivalent criteria and shown to outperform schemes based on only constellation rotation while still enjoying a low-complexity ML decoding algorithm. Extensions to the case of 4 transmit antennas are reported in [4].
Neural and cardiac toxicities associated with 3,4-methylenedioxymethamphetamine (MDMA).

(±)-3,4-Methylenedioxymethamphetamine (MDMA) is a commonly abused illicit drug which affects multiple organ systems. In animals, high-dose administration of MDMA produces deficits in serotonin (5-HT) neurons (e.g., depletion of forebrain 5-HT) that have been viewed as neurotoxicity. Recent data implicate MDMA in the development of valvular heart disease (VHD). The present paper reviews several issues related to MDMA-associated neural and cardiac toxicities. The hypothesis of MDMA neurotoxicity in rats is evaluated in terms of the effects of MDMA on monoamine neurons, the use of scaling methods to extrapolate MDMA doses across species, and functional consequences of MDMA exposure. A potential treatment regimen (l-5-hydroxytryptophan plus carbidopa) for MDMA-associated neural deficits is discussed. The pathogenesis of MDMA-associated VHD is reviewed with specific reference to the role of valvular 5-HT2B receptors. We conclude that pharmacological effects of MDMA occur at the same doses in rats and humans. High doses of MDMA that produce 5-HT depletions in rats are associated with tolerance and impaired 5-HT release. Doses of MDMA that fail to deplete 5-HT in rats can cause persistent behavioral dysfunction, suggesting even moderate doses may pose risks. Finally, the MDMA metabolite, 3,4-methylenedioxyamphetamine (MDA), is a potent 5-HT2B agonist which could contribute to the increased risk of VHD observed in heavy MDMA users.
Electronic Quantification of Protein Biomarkers Based on Bead Aggregate Sizing

We demonstrate a novel protein sensing method using detection of bead aggregates of different sizes in a micro-fluidic impedance cytometer. We utilize micro-fabricated coplanar electrodes at the base of our micro-channel to measure the impedance. When the single beads or bead aggregates pass through the electrodes, a difference in impedance change is detected. We measure these signals using a lock-in amplifier. Due to the difference in impedance change for unbound beads compared with protein-bound bead aggregates, we can differentiate the two types from each other electronically. We demonstrate proof-of-concept using streptavidin and biotin coated beads.
Dynamics of an oscillator with delay parametric excitation

This paper involves the dynamics of a delay limit cycle oscillator being driven by a time-varying perturbation in the delay: x=−x(t−T(t))−ϵx3 with delay T(t)=π2+ϵk+ϵcosωt. This delay is chosen to periodically cross the stability boundary for the x=0 equilibrium in the constant-delay system. For most of parameter space, the system is non-resonant, leading to quasiperiodic behavior. However, a region of 2:1 resonance is shown to exist where the system׳s response frequency is entrained to half of the forcing frequency ω. By a combination of analytical and numerical methods, we find that the transition between quasiperiodic and entrained behavior consists of a variety of local and global bifurcations, with corresponding regions of multiple stable and unstable steady-states.
Agricultural development and wheat breeding in the 20th Century

Tributes to wheat and its contribution to agriculture and humanity over the centuries can be found on carvings on utensils, pictographs from early civilizations, and in many religious writings. The Food and Agriculture Organization of the United Nations selected as their emblem a spike of wheat rising above the Latin inscription Fiat Panis (‘Let there be bread’).
Numerical experiments with an adaptive model of a marine ecosystem represented by the reaction-diffusion equations

We consider the role of diffusion in the formation of space-time processes in an adaptive model of a marine ecosystem. It is shown that the consideration of the diffusion in the ecosystem model constructed by the method of adaptive balance of causes results in a system of Kolmogorov–Petrovsky–Piskunov reaction-diffusion equations. We propose a model of an ecosystem including seven Kolmogorov–Petrovsky–Piskunov equations for the concentrations of phytoplankton and zooplankton, biological resources, oxygen, nutrients, detritus, and carbon dioxide. In numerical experiments performed using the model, we obtained one-dimensional and two-dimensional distributions of parameters of the ecosystem for various coefficients of diffusion. The analysis of results shows that the model of ecosystem based on the Kolmogorov–Petrovsky–Piskunov equations can generate dissipative structures, i.e., distributions of concentrations of interacting substances that are stationary in time and inhomogeneous in space.
X.—Notice of a Bottle-nosed Dolphin (Delphinus Tursio, Fabr.) upon the Suffolk coast

(1849). X.—Notice of a Bottle-nosed Dolphin (Delphinus Tursio, Fabr.) upon the Suffolk coast. Annals and Magazine of Natural History: Vol. 4, No. 20, pp. 100-102.
Beyond the New Conception of Teacher Induction

During the past 20 years the term induction was given new meaning in education, replacing the traditional conception. Today, induction refers to preplanned, structured, and short term assistance programs offered in schools for beginning teachers. This new conception owes its popularity to three convergent influences: educational research, political intrusions, and educators' reform proposals. Benefits of this new conception include the attention it gives to beginning teachers. Its problems include (a) trying to do too much, (b) contriving collegiality, (c) fostering competition among teachers, (d) neglecting teachers' needs, (e) increasing custodial orientations among teachers, and (e) failing to accommodate personal-developmental needs of teachers. Teaching is an intellectual, moral, and political endeavor, yet the new conception ignores this. Alternative conceptions of induction should begin with these unique qualities of teaching and should focus on developing teachers' identities and their adaptive as...
Hydrodynamic operators in atomistic model theories of liquid 4He

Abstract Theories of several different atomistic models of superfluid helium are known to be encompassed by correlated basis function (CBF) formalism. In this paper some of the basic CBF results for liquid 4He are developed in terms of hydrodynamic operators, and cross links are thereby established between atomistic and hydrodynamic descriptions of the system.
The Dynamics of Ligand Barrier Crossing inside the Acetylcholinesterase Gorge

The dynamics of ligand movement through the constricted region of the acetylcholinesterase gorge is important in understanding how the ligand gains access to and is released from the active site of the enzyme. Molecular dynamics simulations of the simple ligand, tetramethylammonium, crossing this bottleneck region are conducted using umbrella potential sampling and activated flux techniques. The low potential of mean force obtained is consistent with the fast reaction rate of acetylcholinesterase observed experimentally. From the results of the activated dynamics simulations, local conformational fluctuations of the gorge residues and larger scale collective motions of the protein are found to correlate highly with the ligand crossing.