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1. Paul J. Lee, MD* 2. Leonard R. Krilov, MD† 1. *Children’s Medical Center, Winthrop-University Hospital, Mineola, NY. 2. †State University of New York at Stony Brook School of Medicine, Stony Brook, NY. 1. CDC Health Information for International Travel 2016 . Centers for Disease Control and Prevention. New York, NY: Oxford University Press; 2016. Also available at: http://wwwnc.cdc.gov/travel/page/yellowbook-home. Accessed October 31, 2015 2. 1. Guzman MG, 2. Harris E Dengue . Guzman MG, Harris E Lancet . 2015;385(9966):453–465 doi: 10.1016/S0140-6736(1460572-9 3. 1. Simmons CP, 2. Farrar JJ, 3. Nguyen V, 4. Wills B. Dengue . Simmons CP, Farrar JJ, Nguyen V, Wills B. N Engl J Med. 2012;366(15):1423–1432. doi: 10.1056/NEJMra1110265 [OpenUrl][1][CrossRef][2][PubMed][3][Web of Science][4] 4. 1. Wattal C, 2. Goel N Infectious Disease Emergencies in Returning Travelers: Special Reference to Malaria, Dengue Fever, and Chikungunya . Wattal C, Goel N. Med Clin North Am. 2012;96(6):1225–1255. doi: 10.1016/j.mcna.2012.08.004 [OpenUrl][5][CrossRef][6][PubMed][7] 5. 1. Weaver SC, 2. Lecuit M. Chikungunya Virus and the Global Spread of a Mosquito-borne Disease . Weaver SC, Lecuit M. N Engl J Med. 2015;372(13):1231–1239. doi: 10.1056/NEJMra1406035 [OpenUrl][8][CrossRef][9][PubMed][10] Dengue is caused by 4 related but distinct flaviviruses, DENV1 – 4, which result in 390 million infections annually, with one-third of the world’s population at risk. Most flaviviruses are transmitted by arthropods, such as mosquitoes and ticks, and are responsible for diseases such as yellow fever, West Nile fever, and Japanese encephalitis. DENV is primarily transmitted by the bite of an infected female Aedes aegypti mosquito, which is endemic to every global region except Europe and Antarctica. Dengue primarily occurs in South and Southeast Asia, Africa, tropical South and Central America, and the Caribbean. In the United States, dengue is a nationally notifiable disease, with 677 cases reported to the Centers for Disease Control and Prevention (CDC) in 2014. It is endemic in Puerto Rico, the US Virgin Islands, and American Samoa. Most US cases result from travel to an endemic area, but locally acquired dengue has been documented in Texas and south Florida. Seventy-five percent of DENV infections in all age groups are asymptomatic, but a spectrum of disease is seen in the remaining 96 million patients, ranging from self-limited fever to life-threatening shock. Classic dengue … [1]: {openurl}?query=rft.jtitle%253DNew%2BEngland%2BJournal%2Bof%2BMedicine%26rft.stitle%253DNEJM%26rft.aulast%253DSimmons%26rft.auinit1%253DC.%2BP.%26rft.volume%253D366%26rft.issue%253D15%26rft.spage%253D1423%26rft.epage%253D1432%26rft.atitle%253DDengue.%26rft_id%253Dinfo%253Adoi%252F10.1056%252FNEJMra1110265%26rft_id%253Dinfo%253Apmid%252F22494122%26rft.genre%253Darticle%26rft_val_fmt%253Dinfo%253Aofi%252Ffmt%253Akev%253Amtx%253Ajournal%26ctx_ver%253DZ39.88-2004%26url_ver%253DZ39.88-2004%26url_ctx_fmt%253Dinfo%253Aofi%252Ffmt%253Akev%253Amtx%253Actx [2]: /lookup/external-ref?access_num=10.1056/NEJMra1110265&link_type=DOI [3]: /lookup/external-ref?access_num=22494122&link_type=MED&atom=%2Fpedsinreview%2F37%2F4%2F179.atom [4]: /lookup/external-ref?access_num=000302608600006&link_type=ISI [5]: {openurl}?query=rft.jtitle%253DThe%2BMedical%2Bclinics%2Bof%2BNorth%2BAmerica%26rft.stitle%253DMed%2BClin%2BNorth%2BAm%26rft.aulast%253DWattal%26rft.auinit1%253DC.%26rft.volume%253D96%26rft.issue%253D6%26rft.spage%253D1225%26rft.epage%253D1255%26rft.atitle%253DInfectious%2Bdisease%2Bemergencies%2Bin%2Breturning%2Btravelers%253A%2Bspecial%2Breference%2Bto%2Bmalaria%252C%2Bdengue%2BFever%252C%2Band%2Bchikungunya.%26rft_id%253Dinfo%253Adoi%252F10.1016%252Fj.mcna.2012.08.004%26rft_id%253Dinfo%253Apmid%252F23102486%26rft.genre%253Darticle%26rft_val_fmt%253Dinfo%253Aofi%252Ffmt%253Akev%253Amtx%253Ajournal%26ctx_ver%253DZ39.88-2004%26url_ver%253DZ39.88-2004%26url_ctx_fmt%253Dinfo%253Aofi%252Ffmt%253Akev%253Amtx%253Actx [6]: /lookup/external-ref?access_num=10.1016/j.mcna.2012.08.004&link_type=DOI [7]: /lookup/external-ref?access_num=23102486&link_type=MED&atom=%2Fpedsinreview%2F37%2F4%2F179.atom [8]: {openurl}?query=rft.jtitle%253DN%2BEngl%2BJ%2BMed.%26rft.volume%253D372%26rft.spage%253D1231%26rft_id%253Dinfo%253Adoi%252F10.1056%252FNEJMra1406035%26rft_id%253Dinfo%253Apmid%252F25806915%26rft.genre%253Darticle%26rft_val_fmt%253Dinfo%253Aofi%252Ffmt%253Akev%253Amtx%253Ajournal%26ctx_ver%253DZ39.88-2004%26url_ver%253DZ39.88-2004%26url_ctx_fmt%253Dinfo%253Aofi%252Ffmt%253Akev%253Amtx%253Actx [9]: /lookup/external-ref?access_num=10.1056/NEJMra1406035&link_type=DOI [10]: /lookup/external-ref?access_num=25806915&link_type=MED&atom=%2Fpedsinreview%2F37%2F4%2F179.atom