cssi/SciSciGPT-SciSciNet huggingface dataset:
Micromorphology and Development of Interfluve Paleosols: A Case Study from the Cenomanian Dunvegan Formation, NE British Columbia, Canada

An obvious use of paleopedology for sequence stratigraphic analysis lies in the demarcation of erosional discontinuities or major pauses in sedimentation that allow us to recognize and map stratigraphically important surfaces, both in outcrop and subsurface. Many interfluve surfaces may be apparent on the basis of sedimentology and regional stratigraphy alone; however, their appearance can change markedly across a study area, making correlation difficult. A pedosedimentary approach has been utilized to reconstruct the sequence of pedogenic and sedimentary events recorded by the development of stratigraphically significant interfluve surfaces. This was based upon sets of closely-spaced thin sections taken from interfluve sequence-bounding paleosols exposed at Beatton River canyon, British Columbia, Canada. Micromorphology, field morphologies, and major physicochemical characteristics of three interfluve paleosols reveals a complex sequence of soil development related both to normal floodplain sedimentation and to periods of prolonged stasis resulting from valley incision. Two main pedosedimentary stages, related to regional changes in rates of generation of accommodation, are recorded at each interfluve, although the resolution, processes, and resultant features vary in a manner reflecting local differences in hydrology, topography, initial parent material composition, and time. These processes have operated through various pedogenic development pathways to produce polygenetic paleosol profiles on these Cretaceous interfluves. The pedosedimentary approach followed in this case study provides a means of deciphering the development of interfluve paleosols based upon detailed microstratigraphic associations and depth functions of their pedogenic features, in conjunction with ancilliary geochemical, mineralogical, sedimentological, and stratigraphic evidence. Consequently, potential sequence boundaries, identified on the basis of regional stratigraphic patterns, can be determined with a high degree of confidence on the basis of intrinsic evidence derived from the record of ancient landscape processes preserved within the interfluve paleosols.
The influence of lung density corrections on treatment planning for primary breast cancer

Abstract Primary breast cancer is generally treated with opposed radiation beams oriented tangentially with respect to the breast. This technique attempts to minimize the dose to the lung and other normal tissues, while at the same time producing a uniform dose distribution throughout the irradiated breast. Although a part of the lung is always included in the tangential breast fields, the effect of this low density tissue on the dose distribution is rarely taken into account. In the present work, the effect of lung density correction on the dose distribution resulting from tangential breast fields is analyzed. Treatment plans for a series of 34 patients treated for breast cancer have been performed using CT data. To study the effect of density corrections on the tangential field treatment plans for these patients, eight separate treatment plans for each patient have been optimized. For each of four photon energies 60 Co, and 4, 6, and 10 MV X rays), treatment plans have been optimized for each patient when density correction is employed, and when unit density is assumed. Four additional dose calculations have been obtained for each patient corresponding to use of the unit density plan, but with density corrections employed in the calculation. The effects that density correction has on the wedge angles used, on the maximum dose ("hot spot") for each of several cross-sectional cuts, on the prescription isodose level which is chosen for each plan, and on homogeneity of the dose distribution over the target volume are all analyzed for the above described plans.
Calculation of Thermal Expansion, Compressiblity, an Melting in Alkali Halides: NaCl and KCl

A parameter-free calculation of the equation of state for KCl and NaCl is presented which gives an accurate prediction of the equilibrium lattice constant over wide-ranging values of pressure and temperature. The results also show a lattice instability which is consistent with melting.
Analysis of anticholinesterase-induced neuromuscular transmission failure.

To define the underlying mechanism of neuromuscular transmission failure induced by anticholinesterases, we simultaneously performed surface recordings of compound muscle action potentials (CMAPs) and intracellular recordings of miniature end-plate potentials (MEPPs), miniature end-plate current (MEPCs), and end-plate potential (EPPs) in rat diaphragms exposed in vitro to 1 × 10−4 to 2 × 10−2 mmol/L neostigmine methylsulfate. At low concentrations of neostigmine, repetitive stimulation of the phrenic nerve resulted in decrement followed by complete recuperation of CMAP amplitudes. This bimodal pattern was associated with maximal end-plate depolarization at the beginning of the stimulation period, increased MEPP amplitudes, and prolonged time constants of MEPC decays. Higher concentrations of neostigmine resulted in a unimodal decline of amplitudes of CMAPs and EPPS, reduced MEPP amplitudes, and a double exponential time course of MEPC decays. These results indicate that low concentrations of anticholinesterases impaired neuromuscular transmission by producing transient depolarization of the end-plate region. Higher concentrations induced desensitization and direct blockade of the end-plate receptor channel, probably in its open conformation. © 1993 John Wiley & Soncs, Inc.
Adaptive responses to genotoxic damage: bacterial strategies to prevent mutation and cell death.

Bacteria are able to induce defense and DNA repair systems that specifically counteract the toxic effects of some important natural agents. «Adaptive responses» to alkylation and oxidation damage have revealed novel strategies for escape from certain kinds of genetic damage.
Chemical, optical, vibrational and luminescent properties of hydrogenated silicon-rich oxynitride films

Abstract X-ray photoelectron spectroscopy, spectroscopic ellipsometry, Fourier transform infrared and room temperature photoluminescence spectroscopy has been used to investigate the chemical, optical, vibrational and luminescent properties of Plasma Enhanced Chemical Vapor Deposited SiO x N y /H (0.17≤ x ≤0.96; 0.07≤ y ≤0.27), hydrogenated silicon-rich oxynitride (SRON). The linear dependence of the refractive index of the SRON films on the O/Si ratio was established. The photoluminescence from the SRON films were attributed to the embedded amorphous silicon clusters in the films. The dependence of luminescence maximum values on the O/Si and O/N ratios has been explored. We postulate that at O/Si ratio of 0.18 and an O/N ratio of 2.0 (SiO 0.18 N 0.09 ) the film underwent a transformation from silicon-rich oxynitride to a-Si/H film with oxygen and nitrogen impurities.
Abstract 5711: Applying new light to the detection and treatment of brain cancers using targeted photodynamic therapy

Proceedings: AACR 103rd Annual Meeting 2012‐‐ Mar 31‐Apr 4, 2012; Chicago, IL Currently, an estimated 11.4 million people in the US have been affected by cancer and this number is expected to double by 2020 as indicated by the NIH NCI in 2006. Each year approximately 20% of these people are expected to die of cancer, with brain cancers among the most deadly. Brain cancer patients have a median life expectancy of only 6-10 months after diagnosis, and those with recurring brain cancer survive less than 20 weeks after any therapeutic regime. Consequently, there is a critical need to develop and improve the detection, diagnosis, and treatment of brain cancers, including gliomas. Theranostic drugs have the potential to do all of these and are becoming lifesaving alternatives. However, the current standard of care suffers from lack of specificity and systemic toxicity, often requiring invasive surgical procedures. These are significant obstacles when dealing with minimizing offsite damage to the healthy brain while maximizing treatment efficacy in the tumor. Our study presents a novel drug delivery platform using targeted-gold nanoparticles (Au NP) to deliver a therapeutic photodynamic therapy (PDT) drug, phthalocyanine 4 (Pc 4), across the blood-brain tumor barrier (BBTB), which allows both detection and treatment of gliomas within mere hours. Targeting Pc 4 to cancer-specific biomarkers concentrates the drug specifically at the brain tumor, significantly reducing collateral damage to healthy brain tissue. Once Pc 4 is delivered, it offers selectivity based on its defined light activation. Our targeted delivery vehicle possesses several advantages over systemic drug delivery: greater control over bioavailability of the drug, controlled release of Pc 4 directly to the site, lower concentration of drug required for PDT effect, and avoidance of systemic drug exposure. The drug delivery mechanism of targeted-Au NP Pc 4 was investigated utilizing in vivo and in vitro fluorescence imaging, immunohistochemistry, elemental analysis, biodistribution studies, and therapeutic efficacy. We are able to target cancer biomarkers specifically, deliver hydrophobic drugs across the BBTB, increase drug accumulation into the tumor, alter drug localization, and enhance PDT killing affect. As a result, this study presents a unique application of PDT to the treatment of brain tumors using photosensitizing drugs like Pc 4. Citation Format: {Authors}. {Abstract title} [abstract]. In: Proceedings of the 103rd Annual Meeting of the American Association for Cancer Research; 2012 Mar 31-Apr 4; Chicago, IL. Philadelphia (PA): AACR; Cancer Res 2012;72(8 Suppl):Abstract nr 5711. doi:1538-7445.AM2012-5711
Effect of different types and locations of the electrode source of an extra low voltage electrical stimulation system on beef quality

An extra low voltage (45V) electrical stimulation (ES) system was used to determine the effects of using different types and locations of the positive electrode and negative ground of the ES system on beef carcass quality. Thirty-three Angus heifers (22 months of age) were assigned at slaughter to one of six ES treatments (trt): (1) rectal probe with a ground inserted in the incision made below the brisket during exsanguination, (2) rectal probe with ground inserted in the neck above the atlas joint, (3) rectal probe with a ground attached to the lower mandible, (4) muzzle clamp with a ground inserted in the shackled leg, (5) nasal clamp with a ground inserted in the shackled leg and (6) non-stimulated controls. Stimulation was generated using a full wave rectified pulsating direct current of 16 Hz for a duration of 90s within 3 min of exsanguination. Carcasses were chilled at 2°C and evaluated at 24h post mortem. Regardless of type or where the electrodes were placed within the carcass, all ES trt produced a more rapid drop in pH than the control group. Differences in the effectiveness of the various ES trt on improving meat tenderness were observed. For four selected muscles of the carcass (longissimus, semimembranosus, biceps femoris and triceps brachii) the most consistent and uniform improvement in tenderness was found using ES trt 1 or trt 3. The only drawback associated with trt 1 was the ineffectiveness in eliminating the formation of heat-ring. The other ES trt were successful in alleviating this problem. This study indicates that type and locations of electrode source in an extra voltage ES system are important factors to consider in developing an efficacious low voltage ES system. This work also suggests successful implementation of extra low voltage carcass ES for commercial use if specific types of rectal probe electrode systems are used.
Plasma polymerization of methyl methacrylate: a photoresist for 3D applications

The use of plasma polymerized methyl methacrylate (PPMMA) as a deep UV photoresist is described. By depositing a light sensitive polymer film from a plasma, very irregular surfaces can be coated and patterned. Other key parameters for a photoresist are photosensitivity, stability, selectivity, and resolution. These parameters are used here as a means of optimizing the plasma process, exposure, and development cycle. The optimum process sequence results in stable films which withstand subsequent exposure to acetone and isopropyl alcohol, have a line width resolution of at least 1.5 mu m, and have a selectivity of at least 70%. >
Animating suspended particle explosions

This paper describes a method for animating suspended particle explosions. Rather than modeling the numerically troublesome, and largely invisible blast wave, the method uses a relatively stable incompressible fluid model to account for the motion of air and hot gases. The fluid's divergence field is adjusted directly to account for detonations and the generation and expansion of gaseous combustion products. Particles immersed in the fluid track the motion of particulate fuel and soot as they are advected by the fluid. Combustion is modeled using a simple but effective process governed by the particle and fluid systems. The method has enough flexibility to also approximate sprays of burning liquids. This paper includes several demonstrative examples showing air bursts, explosions near obstacles, confined explosions, and burning sprays. Because the method is based on components that allow large time integration steps, it only requires a few seconds of computation per frame for the examples shown.
Strategic Leaders: Determining Successful Presidential Opinion Leadership Tactics Through Public Appeals

Most scholars find presidents generally fail at moving the public's views on policy; however, although presidents may fail at opinion leadership at the aggregate level, examining specific communication tactics may yield a more nuanced view of when presidents succeed or fail at leadership. In this article, using a comprehensive data set spanning 1953 to 2001, several strategic communication tactics through which the president might influence temporary opinion movement are examined. Findings show that presidential use of nationally televised addresses is the most consistently effective strategy to enhance presidential leadership, but the effect is lessened for later serving presidents. Strategies involving domestic travel never positively affect leadership, while televised interactions with the media always negatively affect leadership success. The cumulative results imply that presidents can momentarily lead public opinion with particular tactics and that the conditions enhancing leadership are partially i...
Gene Transfer of Manganese Superoxide Dismutase Extends Islet Graft Function in a Mouse Model of Autoimmune Diabetes

Islet transplantation is a promising cure for diabetes. However, inflammation, allorejection, and recurrent autoimmune damage all may contribute to early graft loss. Pancreatic islets express lower levels of antioxidant genes than most other tissues of the body, and β-cells in particular are sensitive to oxidative damage. Therefore, damage from oxidative stress may pose a major obstacle to islet replacement therapy in that both the islet isolation and transplantation processes generate oxygen radicals. To determine whether antioxidant gene overexpression in isolated pancreatic islets can prevent oxidative damage and prolong islet function after transplantation, we used the NOD mouse model to study oxidative stress encountered during both transplantation and autoimmune attack. We transferred an antioxidant gene, manganese superoxide dismutase (MnSOD), by adenoviral infection into isolated islets that were transplanted into streptozotocin-treated NODscid recipient mice. Functioning islet grafts were subsequently exposed to diabetogenic spleen cells and monitored until graft failure. The results show that islet grafts overexpressing MnSOD functioned ∼50% longer than control grafts. This significant prolongation of graft function suggests that the antioxidant activity of MnSOD is beneficial to transplanted islet survival and may be used in combination with other strategies aimed at islet graft protection.
Culturally Targeted Patient Navigation for Increasing African Americans' Adherence to Screening Colonoscopy: A Randomized Clinical Trial

Background: Patient navigation has been an effective intervention to increase cancer screening rates. This study focuses on predicting outcomes of screening colonoscopy for colorectal cancer among African Americans using different patient navigation formats. Methods: In a randomized clinical trial, patients more than 50 years of age without significant comorbidities were randomized into three navigation groups: peer-patient navigation ( n = 181), pro-patient navigation ( n = 123), and standard ( n = 46). Pro-patient navigations were health care professionals who conducted culturally targeted navigation, whereas peer-patient navigations were community members trained in patient navigation who also discussed their personal experiences with screening colonoscopy. Two assessments gathered sociodemographic, medical, and intrapersonal information. Results: Screening colonoscopy completion rate was 75.7% across all groups with no significant differences in completion between the three study arms. Annual income more than $10,000 was an independent predictor of screening colonoscopy adherence. Unexpectedly, low social influence also predicted screening colonoscopy completion. Conclusions: In an urban African American population, patient navigation was effective in increasing screening colonoscopy rates to 15% above the national average, regardless of patient navigation type or content. Impact: Because patient navigation successfully increases colonoscopy adherence, cultural targeting may not be necessary in some populations. Cancer Epidemiol Biomarkers Prev; 22(9); 1577–87. ©2013 AACR .
Expert Practice in Physical Therapy

Background and Purpose. The purpose of this qualitative study was to identify the dimensions of clinical expertise in physical therapy practice across 4 clinical specialty areas: geriatrics, neurology, orthopedics, and pediatrics. Subjects. Subjects were 12 peer-designated expert physical therapists nominated by the leaders of the American Physical Therapy Association sections for geriatrics, neurology, orthopedics, and pediatrics. Methods. Guided by a grounded theory approach, a multiple case study research design was used, with each of the 4 investigators studying 3 therapists working in one clinical area. Data were obtained through nonparticipant observation, interviews, review of documents, and analysis of structured tasks. Videotapes made during selected therapist-patient treatment sessions were used as a stimulus for the expert therapist interviews. Data were transcribed, coded, and analyzed through the development of 12 case reports and 4 composite case studies, one for each specialty area. Results. A theoretical model of expert practice in physical therapy was developed that included 4 dimensions: (1) a dynamic, multidimensional knowledge base that is patient-centered and evolves through therapist reflection, (2) a clinical reasoning process that is embedded in a collaborative, problem-solving venture with the patient, (3) a central focus on movement assessment linked to patient function, and (4) consistent virtues seen in caring and commitment to patients. Conclusion and Discussion. These findings build on previous research in physical therapy on expertise. The dimensions of expert practice in physical therapy have implications for physical therapy practice, education, and continued research.
Application of a Mickens finite-difference scheme to the cylindrical Bratu-Gelfand problem

The boundary value problem Δu + λeu = 0 where u = 0 on the boundary is often referred to as “the Bratu problem.” The Bratu problem with cylindrical radial operators, also known as the cylindrical Bratu-Gelfand problem, is considered here. It is a nonlinear eigenvalue problem with two known bifurcated solutions for λ λc and a unique solution when λ = λc. Numerical solutions to the Bratu-Gelfand problem at the critical value of λc = 2 are computed using nonstandard finite-difference schemes known as Mickens finite differences. Comparison of numerical results obtained by solving the Bratu-Gelfand problem using a Mickens discretization with results obtained using standard finite differences for λ < 2 are given, which illustrate the superiority of the nonstandard scheme. © 2004 Wiley Periodicals, Inc. Numer Methods Partial Differential Eq 20: 327–337, 2004
Use of forward sensitivity analysis method to improve code scaling, applicability, and uncertainty (CSAU) methodology

Abstract Since the code scaling, applicability, and uncertainty (CSAU) methodology was proposed about two decades ago, it has been widely used for new reactor designs and existing LWRs power uprates. In spite of these huge successes, CSAU has been criticized for the need of further improvement, focusing on two main issues – lack of objectiveness and high cost. With the effort to develop next generation safety analysis codes, new opportunities appear to take advantage of new numerical methods, better physical models, and modern uncertainty qualification methods. Forward sensitivity (FS) analysis directly solves the partial differential equations for parameter sensitivities. Moreover, our work shows that time and space steps can be treated as special sensitivity parameters so that numerical errors can be directly compared with physical uncertainties. It should be noted that FS analysis is an intrusive uncertainty quantification method that requires the user of the method to be familiar with the simulation code structure including numerical spatial and temporal integration techniques. When the FS analysis is implemented in a new advanced system analysis code, CSAU could be significantly improved by quantifying numerical errors and allowing a quantitative PIRT (Q-PIRT) to reduce subjective judgment and improve efficiency. This paper will review the issues related to the current CSAU implementations, introduce FS analysis, show a simple example to perform FS analysis, and discuss potential improvements on CSAU with FS analysis. Finally, the general research direction and requirements to use FS analysis in an advanced system analysis code will be discussed.
Integrated, Effective and Average Interdiffusion Coefficients and their Applications in Multicomponent Alloys for Energy Production Technologies

Solid-state diffusion is a subject of great interest for many intellectual merits and practical applications. It also provides excellent educational studies with cross-fertilization of science and technology. This paper examines the importance of multicomponent-multiphase interdiffusion with specific examples from materials and coatings for components in advanced energy production systems, including gas turbines and nuclear reactors. Results and analysis from laboratory experiments are presented in terms of interdiffusion fluxes, integrated interdiffusion coefficients, effective interdiffusion coefficients, and average multicomponent interdiffusion coefficients. Applications are highlighted for materials and coatings for components in advanced energy production technologies. Additional consideration is given to the refined approach to assess composition-dependent interdiffusion coefficients in multicomponent alloys.
Discovery of five conserved β-defensin gene clusters using a computational search strategy

The innate immune system includes antimicrobial peptides that protect multicellular organisms from a diverse spectrum of microorganisms. β-Defensins comprise one important family of mammalian antimicrobial peptides. The annotation of the human genome fails to reveal the expected diversity, and a recent query of the draft sequence with the blast search engine found only one new β-defensin gene (DEFB3). To define better the β-defensin gene family, we adopted a genomics approach that uses hmmer, a computational search tool based on hidden Markov models, in combination with blast. This strategy identified 28 new human and 43 new mouse β-defensin genes in five syntenic chromosomal regions. Within each syntenic cluster, the gene sequences and organization were similar, suggesting each cluster pair arose from a common ancestor and was retained because of conserved functions. Preliminary analysis indicates that at least 26 of the predicted genes are transcribed. These results demonstrate the value of a genomewide search strategy to identify genes with conserved structural motifs. Discovery of these genes represents a new starting point for exploring the role of β-defensins in innate immunity.
Shape control of mesoporous silica nanomaterials templated with dual cationic surfactants and their antibacterial activities

Mesoporous silica nanomaterials of different shapes (film, platelet, sphere, rod) were synthesized simply by tuning the mole ratio of dual cationic surfactant templates, cetyltrimethylammonium bromide (CTAB) and tetrabutylammonium iodine (TBAI). The film showed the most potent antibacterial activity against mycobacteria.
Activation of RAW264.7 Macrophages by Bacterial DNA and Lipopolysaccharide Increases Cell Surface DNA Binding and Internalization

Bacterial DNA containing unmethylated CpG motifs is a pathogen-associated molecular pattern (PAMP) that interacts with host immune cells via a toll-like receptor (TLR) to induce immune responses. DNA binding and internalization into cells is independent of TLR expression, receptor-mediated, and required for cell activation. The objective of this study was to determine whether exposure of immune cells to bacterial DNA affects DNA binding and internalization. Treatment of RAW264.7 cells with CpG oligodeoxynucleotide (ODN) for both 18 and 42 h resulted in a significant increase in DNA binding, whereas non-CpG ODN had no effect on DNA binding. Enhanced DNA binding was non-sequence-specific, inhibited by unlabeled DNA, showed saturation, was consistent with increased cell surface DNA receptors, and resulted in enhanced internalization of DNA. Treatment with Escherichia coli DNA or lipopolysaccharide (LPS) also resulted in a significant increase in DNA binding, but treatment with interleukin-1α, tumor necrosis factor-α, or phorbol 12-myristate 13-acetate had no effect on DNA binding. Soluble factors produced in response to treatment with CpG ODN or LPS did not affect DNA binding. These studies demonstrate that one consequence of activating the host innate immune response by bacterial infection is enhanced binding and internalization of DNA. During this period of increased DNA internalization, RAW264.7 cells were hypo-responsive to continued stimulation by CpG ODN, as assessed by tumor necrosis factor-α activity. We speculate the biological significance of increasing DNA binding and internalization following interaction with bacterial PAMPs may provide a mechanism to limit an ongoing immune inflammatory response by enhancing clearance of bacterial DNA from the extracellular environment.
Extruded scintillator for the Calorimetry applications

An extrusion line has been installed and successfully operated at FNAL (Fermi National Accelerator Laboratory) in collaboration with NICADD (Northern Illinois Center for Accelerator and Detector Development). This new Facility will serve to further develop and improve extruded plastic scintillator. Recently progress has been made in producing co‐extruded plastic scintillator, thus increasing the potential HEP applications of this Facility. The current R&D work with extruded and co‐extruded plastic scintillator for a potential ALICE upgrade, the ILC calorimetry program and the MINERvA experiment show the attractiveness of the chosen strategy for future experiments and calorimetry. We extensively discuss extruded and co‐extruded plastic scintillator in calorimetry in synergy with new Solid State Photomultipliers. The characteristics of extruded and co‐extruded plastic scintillator will be presented here as well as results with non‐traditional photo read‐out.
Diet and the behavior of children with attention deficit disorder

A spectrum of dietary recommendations designed to ameliorate dysfunctional behavioral patterns in children with attention deficit disorder or hyperactivity, and the efficacy of the particular diets, is examined. Existing research on diet and children's behavior is reviewed, and preferred methods of treatment, based on comprehensive medical examination and parental responses to recommendations, are discussed.
The Terms “Loci Communes” and “Loci” in Melanchthon

Philip Melanchthon was the author of the first book of Protestant theology, which he called Loci communes rerum theologicarum seu hypotyposes theologicae (Wittenberg, 1521). As a first it is worth some study, for firsts are likely to be models for later things of their kind. Moreover, while Melanchthon is by some considered to depart from early Protestant thought (cf. Philippism), Luther gave unqualified and almost extravagant praise to his young collaborator's first work. This justifies putting at least the 1521 edition in the fundamental canon of Protestantism. Finally, if suth is its importance Melanchthon's method deserves examination.
Differential effects of speaker and vowel variability on fricative perception.

Previous research has shown that listeners' identifications of synthetic fricative noises are influenced by both rounding on an adjacent vowel and by the sex of the speaker who produced the adjacen...
Delayed effects of ionizing radiation on the ear

The question of damage to the ear from exposure to ionizing radiation was addressed by exposing groups of chinchillas to fractioned doses of radiation (2 Gy per day) for total doses ranging from 40 to 90 Gy. In order to allow any delayed effects of radiation to become manifest, the animals were sacrificed two years after completion of treatment and their temporal bones were prepared for microscopic examination. The most pronounced effect of treatment was degeneration of sensory and supporting cells and loss of eighth nerve fibers in the organ of Corti. Damage increased with increasing dose of radiation. The degree of damage found in many of these ears was of sufficient magnitude to produce a permanent sensorineural hearing loss.
Bacterial community composition during two consecutive NE Monsoon periods in the Arabian Sea studied by denaturing gradient gel electrophoresis (DGGE) of rRNA genes

Abstract Horizontal and vertical variations in bacterial community composition were examined in samples collected during two Joint Global Ocean Flux Study (JGOFS) Arabian Sea cruises in 1995. The cruises, 11 months apart, took place during two consecutive NE Monsoon periods (January and December). Bacteria were harvested by filtration from samples collected in the mixed layer, mid-water, and deep sea at stations across the study area. Total bacterial community genomic DNA was analyzed by PCR amplification of 16S rRNA gene fragments, followed by denaturing gradient gel electrophoresis (DGGE). In total, 20 DGGE bands reflecting unique or varying phylotypes were excised, cloned and sequenced. Amplicons were dominated by bacterial groups commonly found in oceanic waters (e.g., the SAR11 cluster of α -Proteobacteria and cyanobacteria), but surprisingly none of the sequenced amplicons were related to γ -Proteobacteria or to members of the Cytophaga-Flavobacter-Bacteroides phylum. Amplicons related to magnetotactic bacteria were found for the first time in pelagic oceanic waters. The DGGE banding patterns revealed a dominance of ≈15 distinguishable amplicons in all samples. In the mixed layer the bacterial community was dominated by the same ≈15 phylotypes at all stations, but unique phylotypes were found with increasing depth. Except for cyanobacteria, comparison of the bacterial community composition in surface waters from January and December 1995 showed only minor differences, despite significant differences in environmental parameters. These data suggest a horizontal homogeneity and some degree of seasonal predictability of bacterial community composition in the Arabian Sea.
A scheme to lower the resonant frequency of the microstrip patch antenna

Simple schemes are presented for lowering the resonant frequency of the rectangular patch antenna without changing its size. In particular, by placing a perturbance below the patch it is shown that as much as a 30% decrease from the resonant frequency of the unperturbed patch can be achieved. The specific configurations considered include a cavity-backed and an aperture-backed patch, and for each case design curves are presented. >
STAG2 promotes error correction in mitosis by regulating kinetochore–microtubule attachments

Mutations in the STAG2 gene are present in ∼20% of tumors from different tissues of origin. STAG2 encodes a subunit of the cohesin complex, and tumors with loss-of-function mutations are usually aneuploid and display elevated frequencies of lagging chromosomes during anaphase. Lagging chromosomes are a hallmark of chromosomal instability (CIN) arising from persistent errors in kinetochore–microtubule (kMT) attachment. To determine whether the loss of STAG2 increases the rate of formation of kMT attachment errors or decreases the rate of their correction, we examined mitosis in STAG2-deficient cells. STAG2 depletion does not impair bipolar spindle formation or delay mitotic progression. Instead, loss of STAG2 permits excessive centromere stretch along with hyperstabilization of kMT attachments. STAG2-deficient cells display mislocalization of Bub1 kinase, Bub3 and the chromosome passenger complex. Importantly, strategically destabilizing kMT attachments in tumor cells harboring STAG2 mutations by overexpression of the microtubule-destabilizing enzymes MCAK (also known as KIF2C) and Kif2B decreased the rate of lagging chromosomes and reduced the rate of chromosome missegregation. These data demonstrate that STAG2 promotes the correction of kMT attachment errors to ensure faithful chromosome segregation during mitosis.
On the accurate calibration of the SeaWinds radar antenna: a cylindrical near-field measurement approach

A multipolarization, multi-incidence angle conical scanning Ku-band radar antenna is being designed and calibrated at the Jet Propulsion Laboratory (JPL) for the SeaWinds Scatterometer instrument. To calibrate the radar's performance, it is essential to accurately determine the antenna gain and radiation pattern characteristics over wide angular range. Such characterizations may be performed on a far-field range or in an indoor near-field measurement facility. Among the advantage of the latter is that the antenna is in a controlled environment. This paper demonstrates the utility of a cylindrical near-field measurement approach for the SeaWinds radar antenna calibration. Both generalized measurement error models and measured tests on a standard gain horn and NASA Scatterometer instrument antenna have been performed to achieve and verify the desired calibration accuracy. A comparison between far-field measured data and those obtained from cylindrical near-field measurements was found in excellent agreement.
High Level Power Estimation Models for FPGAs

This paper presents a high level power estimation methodology for the FPGA-based designs. The high level estimation techniques are usually targeted towards ASIC designs. We evaluate the applicability of these techniques for FPGAs. The current techniques give a separate power estimation model for each IP. Instead, our method aims to develop a common power model for multiple IPs. This is made possible by the structured nature of FPGA fabrics having fixed resources -- LUTs, multipliers, BRAMs, etc. We developed a statistical learning based approach that includes the effect of design specific information as well as FPGA resource utilization information. The work demonstrates the effect of varying the activity-factor of the design and the FPGA resources consumption on dynamic power, using a set of 13 IPs as benchmarks. We also study the effect of statistical clustering technique on the model accuracy. The average percentage error in the model stayed around 4%for activity-factor variation and around 6% for resource-utilization variation.
MRI findings in a case of transient cortical blindness after cardiac catheterization.

The magnetic resonance imaging findings in a case of transient cortical blindness (TCB) after cardiac catheterization are described for the first time. In addition, a literature review of TCB, comparison with reversible posterior leukoencephalopathy, and a hypothesis regarding the pathophysiology of TCB are presented.
Baseline clinical characteristics predict follow‐up clinic attendance in patients undergoing endoscopic sinus surgery for chronic rhinosinusitis

Background The objective of this work was to describe the association between baseline clinical characteristics and attendance at follow-up visits after endoscopic sinus surgery (ESS). Methods A retrospective review of chronic rhinosinusitis (CRS) patients electing ESS at a tertiary-care center (2011-2013) was conducted. Baseline characteristics were studied for association with clinic attendance at 3, 6, 12, and 24 months post-ESS. Results We identified 268 patients. Significant decline occurred in the number of patients following up after ESS (3 months: 246 patients [92%]; 6 months: 145 [54%]; 12 months: 94 [35%]; and 24 months: 90 [34%]). Older patients were more likely to follow up at 3 months (mean age 55.7 vs 48.4 years, p = 0.04) and 6 months (57.5 vs 52.3 years; p = 0.01) post-ESS. Those with higher preoperative sinus computed tomography (CT) (Lund-Mackay) scores were more likely to follow at 6 months (11.8 vs 10.3, p = 0.01), 12 months (12.6 vs 10.3, p < 0.001), and 24 months (12.2 vs 10.5, p = 0.01). At 12 months having asthma (p = 0.03), previous ESS (p = 0.04), nasal polyps (p < 0.0001), allergic fungal sinusitis (AFS) (p = 0.002), and granulomatosis with polyangiitis (GPA) (p = 0.01) were associated with clinic attendance. At 24 months asthma status (p = 0.003), previous ESS (p = 0.002), AFS (p = 0.04), GPA (p = 0.001), and aspirin-exacerbated respiratory disease (AERD) (p = 0.006) were associated with higher attendance. Geographical proximity did not impact attendance. Conclusion The sharpest decline in patient follow-up occurred between 3–6 months after ESS. Higher preoperative sinus CT scores, previous ESS, presence of asthma, and diagnosis of recalcitrant CRS subtype (nasal polyps, AERD, AFS, GPA) were factors associated with increased long-term attendance.
Statistical physics: Localization goes long

Signatures of many-body localization have been observed in a one-dimensional chain of trapped ions, heralding new studies of the interplay between localization and long-range interactions.
The intimate and controversial relationship between voltage‐gated proton channels and the phagocyte NADPH oxidase

One of the most fascinating and exciting periods in my scientific career entailed dissecting the symbiotic relationship between two membrane transporters, the Nicotinamide adenine dinucleotide phosphate reduced form (NADPH) oxidase complex and voltage-gated proton channels (HV 1). By the time I entered this field, there had already been substantial progress toward understanding NADPH oxidase, but HV 1 were known only to a tiny handful of cognoscenti around the world. Having identified the first proton currents in mammalian cells in 1991, I needed to find a clear function for these molecules if the work was to become fundable. The then-recent discoveries of Henderson, Chappell, and colleagues in 1987-1988 that led them to hypothesize interactions of both molecules during the respiratory burst of phagocytes provided an excellent opportunity. In a nutshell, both transporters function by moving electrical charge across the membrane: NADPH oxidase moves electrons and HV 1 moves protons. The consequences of electrogenic NADPH oxidase activity on both membrane potential and pH strongly self-limit this enzyme. Fortunately, both consequences specifically activate HV 1, and HV 1 activity counteracts both consequences, a kind of yin-yang relationship. Notwithstanding a decade starting in 1995 when many believed the opposite, these are two separate molecules that function independently despite their being functionally interdependent in phagocytes. The relationship between NADPH oxidase and HV 1 has become a paradigm that somewhat surprisingly has now extended well beyond the phagocyte NADPH oxidase - an industrial strength producer of reactive oxygen species (ROS) - to myriad other cells that produce orders of magnitude less ROS for signaling purposes. These cells with their seven NADPH oxidase (NOX) isoforms provide a vast realm of mechanistic obscurity that will occupy future studies for years to come.
Quantitative determination of ribosome nascent chain stability

Accurate protein folding is essential for proper cellular and organismal function. In the cell, protein folding is carefully regulated; changes in folding homeostasis (proteostasis) can disrupt many cellular processes and have been implicated in various neurodegenerative diseases and other pathologies. For many proteins, the initial folding process begins during translation while the protein is still tethered to the ribosome; however, most biophysical studies of a protein’s energy landscape are carried out in isolation under idealized, dilute conditions and may not accurately report on the energy landscape in vivo. Thus, the energy landscape of ribosome nascent chains and the effect of the tethered ribosome on nascent chain folding remain unclear. Here we have developed a general assay for quantitatively measuring the folding stability of ribosome nascent chains, and find that the ribosome exerts a destabilizing effect on the polypeptide chain. This destabilization decreases as a function of the distance away from the peptidyl transferase center. Thus, the ribosome may add an additional layer of robustness to the protein-folding process by avoiding the formation of stable partially folded states before the protein has completely emerged from the ribosome.
Technology potential and recommendations for action

In this section, the results of the empirical study will be interpreted and consequently the technology potential of the key technology Intelligent Objects and its software-based and hardware-based technologies will be identified according to end-to-end digital integration. Furthermore, Intelligent Objects will be applied to technology paradigm in production logistics to illustrate possible chances of Intelligent Objects in this area. Based on the results recommendations for action will be elaborated.
Immunosuppression in liver tumors: opening the portal to effective immunotherapy

We have recently witnessed substantial progress with immunotherapy for selected diseases. Checkpoint inhibitors and chimeric antigen receptor T (CAR-T) cells are among the most promising agents. Whereas much of the early success with CAR-T cells has been demonstrated with hematological malignancies, important barriers remain for the application of CAR-T cell therapies for the management of metastatic solid tumors. The challenges are particularly apparent when considering primary and metastatic tumors in the liver. At baseline, the intrahepatic space is immunosuppressive and this feature is exploited by malignant cells. Fortunately, our evolving understanding of liver immune cell biology is allowing the development of novel immunotherapeutic strategies for the treatment of liver tumors. Furthermore, the unique anatomic features of the liver make possible highly selective immunotherapeutic delivery approaches that may maximize antitumor efficacy while limiting off-target damage to healthy tissues. This review summarizes the immunobiology of the intrahepatic space and how this knowledge enables identification of hurdles and potential solutions to the barriers facing immunotherapy for liver tumors.
Evidence for the use of “medical marijuana” in psychiatric and neurologic disorders

Abstract Introduction: Cannabis is listed as a Schedule I substance under the Controlled Substances Act of 1970, meaning the US federal government defines it as an illegal drug that has high potential for abuse and no established medical use; however, half of the states in the nation have enacted “medical marijuana” (MM) laws. Clinicians must be aware of the evidence for and against the use of MM in their patients who may consider using this substance. Methods: A PubMed database search was performed using the text string: “Cannabis”[Mesh] OR “Marijuana Abuse”[Mesh] OR “Medical Marijuana”[Mesh] OR “Marijuana Smoking”[Mesh] OR “cannabi*” OR “tetrahydrocannabinol.” The search was further limited to randomized clinical trial publications in English on human subjects to identify articles regarding the therapeutic use of phytocannabinoids for psychiatric and neurologic disorders. Commercially available products (ie, dronabinol, nabilone, nabiximols) and synthetic cannabinoids were excluded from the review. Resu...
Factors Affecting Exam Completion Speed, Exam Performance, and Nonexam Performance

This study investigates how factors such as student achievement goals for a course, language skills, outside work commitments, and test anxiety are related to performance on multiple-choice exams a...
Apparent digestibility of animal, plant and microbial ingredients for Pacific white shrimp Litopenaeus vannamei

A digestibility trial was conducted to determine apparent digestibility coefficients of dry matter, protein, energy and amino acids of animal, plant and microbial ingredients for Pacific white shrimp, Litopenaeus vannamei. The tested ingredients included traditional soybean meal (TSBM), PepsoyGen soybean meal (PSBM), NutriVance soybean meal (NSBM), fish meal (FM), poultry meal (PM), squid hydrolysis (SQH), scallop hydrolysis (SCH), flash dried yeast (FDY), two batches of Ulva meal (UMF and UMS) and bacteria biomass (BB). A basal diet was formulated and produced along with the experimental diets which included 300 g/kg of each ingredient and 700 g/kg of the basal diet. Juvenile shrimp (initial mean weight: 12 g, six shrimp/tank, n = 3) were stocked in a recirculation system. Apparent dry matter, protein and energy digestibility coefficients ranged from −40.11% to 78.51%, 15.17% to 97.03% and 13.33% to 82.56% among different protein sources, respectively. In general, protein and energy digestibilities in soy sources (77.6% to 97.03% and 62.77% to 82.56%, respectively) are higher than the tested animal protein (51.39% to 71.41% and 45.29% to 69.77%, respectively) and single-cell protein sources (15.17% to 53.47% and 13.33% to 40.39%, respectively). Among the three soybean sources, TSBM showed highest protein and energy digestibility. Apparent individual amino acid digestibility coefficients were also variable among different types of ingredients, and there was a reasonable correspondence to protein digestibility. The most digestible feed ingredients for Pacific white shrimp in this study were conventional soybean meal (SBM) and NutriVance soybean meal (NSBM), which indicated that these ingredients are good protein and amino acid sources for Pacific white shrimp. Resultant digestibility data may provide useful information to commercial shrimp feed industry.