cssi/SciSciGPT-SciSciNet huggingface dataset:
Spectral analysis and temperature measurement during flash sintering under AC electric field

Abstract In-situ diffraction experiments were used to study the change in peak profiles of 8YSZ during conventional sintering and flash sintering under AC electric field. Using calibration from a conventionally heated standard, the lattice expansion of 8YSZ under flash conditions was correlated to actual specimen temperature, indicating temperature comparable to that required for conventional sintering. At higher current densities, a temperature rise greater than 2000 °C was reached, which resulted in abnormal grain growth and temperature instability. Microstructural analysis demonstrated that finer grain size can be achieved by limiting the current in order to avoid high specimen temperatures. Experiments varying the thickness of the green compact resulted in higher heat loss due to thermal conduction and corresponding reduction in final density. A replacement to the blackbody radiation model was successfully used to fit the data and explain all effects based on Joule heating as well as provide a flash sintering processing map incorporating furnace temperature, power dissipation, and sample geometry.
RABBITTITE, A NEW URANYL CARBONATE FROM UTAH

Report discussing the investigation of rabbittite, a hydrated calcium magnesium uranyl carbonate found in a mine of the San Rafael district of Emery County, Utah, in July, 1952. Information regarding rabbittite's occurrence, physical/optical properties, chemical composition, and X-ray diffraction data are included.
Synthesis and in vitro biological evaluation of new P2X7R radioligands [11C]halo-GSK1482160 analogs.

Abstract The reference standards halo-GSK1482160 (F-, Br-, and I-) and their corresponding precursors desmethyl-halo-GSK1482160 (F-, Br-, and I-) were synthesized from (S)-1-methyl-5-oxopyrrolidine-2-carboxylic acid or (S)-5-oxopyrrolidine-2-carboxylic acid and 2-halo-3-(trifluoromethyl)benzylamine (F-, Br-, and I-) in one step with 45–93% yields. The target tracers [11C]halo-GSK1482160 (F-, Br-, and I-) were prepared from desmethyl-halo-GSK1482160 (F-, Br-, and I-) with [11C]CH3OTf under basic conditions (NaOH-Na2CO3, solid, w/w 1:2) through N-[11C]methylation and isolated by HPLC combined with SPE in 40–50% decay corrected radiochemical yield. The radiochemical purity was >99%, and the molar activity (AM) at end of bombardment (EOB) was 370–740 GBq/μmol. The potency of halo-GSK1482160 (F-, Br-, and I-) in comparison with GSK1482160 (Cl-) was determined by a radioligand competitive binding assay using [11C]GSK1482160, and the binding affinity Ki values for halo-GSK1482160 (F-, Br-, and I-) and GSK1482160 (Cl-) are 54.2, 2.5, 1.9 and 3.1 nM, respectively.
Sickle cell trait and risk of cognitive impairment in African-Americans: The REGARDS cohort.

Abstract Background Sickle cell anemia may be associated with cognitive dysfunction, and some complications of sickle cell anemia might affect those with sickle cell trait (SCT), so we hypothesized that SCT is a risk factor for cognitive impairment. Methods The Reasons for Geographic and Racial Differences in Stroke (REGARDS) study enrolled a national cohort of 30,239 white and black Americans from 2003 to 7, who are followed every 6 months. Baseline and annual global cognitive function testing used the Six-Item Screener (SIS), a validated instrument (scores range 0–6; ≤ 4 indicates cognitive impairment). Participants with baseline cognitive impairment and whites were excluded. Logistic regression was used to calculate the association of SCT with incident cognitive impairment, adjusted for risk factors. Linear mixed models assessed multivariable-adjusted change in test scores on a biennially administered 3-test battery measuring learning, memory, and semantic and phonemic fluency. Findings Among 7743 participants followed for a median of 7·1 years, 85 of 583 participants with SCT (14·6%) developed incident cognitive impairment compared to 902 of 7160 (12·6%) without SCT. In univariate analysis, the odds ratio (OR) of incident cognitive impairment was 1·18 (95% CI: 0·93, 1·51) for those with SCT vs. those without. Adjustment did not impact the OR. There was no difference in change on 3-test battery scores by SCT status (all p > 0·11). Interpretation In this prospective cohort study of black Americans, SCT was not associated with incident cognitive impairment or decline in test scores of learning, memory and executive function. Funding National Institutes of Health, American Society of Hematology.
Facilitators of and barriers to successful teamwork during resuscitations in a neonatal intensive care unit

Effective teamwork is essential in high-risk healthcare delivery environments. In this study, we aimed to identify facilitators of and barriers to successful teamwork during resuscitations in the NICU Study Design: 36 in-situ interprofessional simulation sessions were held in a level 4 NICU. Each session was followed by a debriefing where staff talked about the simulation scenario but also about their prior experiences during resuscitations in the NICU. Using content analysis, we analyzed the transcriptions of debriefings to address the study aims. Participant responses yielded three major themes: communicating well, getting tasks done well, and working well together. Each main theme had subthemes. Teamwork is a complex process that is enhanced and hindered by a variety of factors. The factors identified in this study can be used to enhance relationship-based teamwork training programs. Future research is needed to determine which teamwork behaviors are most associated with patient outcomes
Alcohol Abstinence Does Not Fully Reverse Abnormalities of Mucosal-Associated Invariant T Cells in the Blood of Patients With Alcoholic Hepatitis.

Objectives Alcoholic hepatitis (AH) develops in approximately 30% of chronic heavy drinkers. The immune system of patients with AH is hyperactivated, yet ineffective against infectious diseases. Mucosal-associated invariant T (MAIT) cells are innate-like lymphocytes that are highly enriched in liver, mucosa, and peripheral blood and contribute to antimicrobial immunity. We aimed to determine whether MAIT cells were dysregulated in heavy drinkers with and without AH and the effects of alcohol abstinence on MAIT cell recovery. Methods MR1 tetramers loaded with a potent MAIT cell ligand 5-(2-oxopropylideneamino)-6-d-ribitylaminouracil were used in multiparameter flow cytometry to analyze peripheral blood MAIT cells in 59 healthy controls (HC), 56 patients with AH, and 45 heavy drinkers without overt liver disease (HDC) at baseline and 6- and 12-month follow-ups. Multiplex immunoassays were used to quantify plasma levels of cytokines related to MAIT cell activation. Kinetic Turbidimetric Limulus Amebocyte Lysate Assay and ELISA were performed to measure circulating levels of 2 surrogate markers for bacterial translocation (lipopolysaccharide and CD14), respectively. Results At baseline, patients with AH had a significantly lower frequency of MAIT cells than HDC and HC. HDC also had less MAIT cells than HC (median 0.16% in AH, 0.56% in HDC, and 1.25% in HC). Further, the residual MAIT cells in patients with AH expressed higher levels of activation markers (CD69, CD38, and human leukocyte antigen [HLA]-DR), the effector molecule granzyme B, and the immune exhaustion molecule PD-1. Plasma levels of lipopolysaccharide and CD14 and several cytokines related to MAIT cell activation were elevated in patients with AH (interferon [IFN]-α, interleukin [IL]-7, IL-15, IL-17, IL-18, IL-23, IFN-γ, and tumor necrosis factor α). Decreased MAIT cell frequency and upregulated CD38, CD69, and HLA-DR correlated negatively and positively, respectively, with aspartate aminotransferase level. MAIT cell frequency negatively correlated with IL-18. HLA-DR and CD38 levels correlated with several cytokines. At follow-ups, abstinent patients with AH had increased MAIT cell frequency and decreased MAIT cell activation. However, MAIT cell frequency was not fully normalized in patients with AH (median 0.31%). Discussion We showed that HDC had a reduction of blood MAIT cells despite showing little evidence of immune activation, whereas patients with AH had a severe depletion of blood MAIT cells and the residual cells were highly activated. Alcohol abstinence partially reversed those abnormalities.
Instabilities and Clumping in Type Ia Supernova Remnants

We present two-dimensional high-resolution hydrodynamical simulations in spherical polar coordinates of a Type Ia supernova interacting with a constant-density interstellar medium. The ejecta are assumed to be freely expanding with an exponential density profile. The interaction gives rise to a double-shocked structure susceptible to hydrodynamical instabilities. The Rayleigh-Taylor instability initially grows, but the Kelvin-Helmholtz instability takes over, producing vortex rings. Provided the simulation is initiated early in the evolution, with a perturbation 1%, the instability reaches its fully developed nonlinear strength within 5 doubling times. The further nonlinear evolution does not depend on the initial conditions. Considering the small initial radii of Type Ia supernovae, they are likely to reach this fully developed phase. The nonlinear instability initially evolves toward longer wavelengths and eventually fades away when the reverse shock front is in the flatter part of the supernova density distribution. On the basis of observations of X-ray knots and the protrusion in the southeast outline of Tycho's supernova remnant, we include clumping in the ejecta because these features cannot be explained by instabilities growing from small perturbations. The clump interaction with the reverse shock induces Rayleigh-Taylor and Kelvin-Helmholtz instabilities on the clump surface that facilitate fragmentation. In order to survive crushing and to have a bulging effect on the forward shock, the clump's initial density ratio to the surrounding ejecta must be at least 100 for the conditions in Tycho's remnant. The 56Ni bubble effect may be important for the development of clumpiness in the ejecta. The observed presence of an Fe clump would then require a nonradioactive origin for this Fe, possibly 54Fe. The large radial distance of the X-ray-emitting Si and S ejecta from the remnant center indicates that they were initially in clumps.
BrainImageR: spatiotemporal gene set analysis referencing the human brain.

Motivation Neuronal analyses such as transcriptomics, epigenetics and genome-wide association studies must be assessed in the context of the human brain to generate biologically meaningful inferences. It is often difficult to access primary human brain tissue; therefore, approximations are made using alternative sources such as peripheral tissues or in vitro-derived neurons. Gene sets from these studies are then assessed for their association with the post-mortem human brain. However, most analyses of post-mortem datasets are achieved by building new computational tools each time in-house, which can cause discrepancies from study to study. The field is in need of a user-friendly tool to examine spatiotemporal expression with respect to the postmortem brain. Such a tool will be of use in the molecular interrogation of neurological and psychiatric disorders, with direct advantages for the disease-modeling and human genetics communities. Results We have developed brainImageR, an R package that calculates both the spatial and temporal association of a dataset with post-mortem human brain. BrainImageR identifies anatomical regions enriched for candidate gene set expression. It further predicts the developmental time point of the sample, a task that has become increasingly important in the field of in vitro neuronal modeling. These functionalities of brainImageR enable a quick and efficient characterization of a given dataset across normal human brain development. Availability and implementation BrainImageR is released under the Creative Commons CC BY-SA 4.0 license and can be accessed directly at brainimager.salk.edu or the R code can be downloaded through github at https://github.com/saralinker/brainImageR.
Synthesis and Characterization of the Mg2SixGe1-x Solid Solution

The Mg 2 Si x Ge 1 - x solid solution was prepared by heating stoichiometric amounts of elemental Mg, Si, and Ge in an argon atmosphere. Both microprobe and X-ray diffraction analysis of the reaction products suggest that homogeneous alloys can be made by heating the elements to 1200 °C, a temperature roughly 100 °C in excess of the melting temperatures for pure Mg 2 Si and Mg 2 Ge. 2 9 Si solid-state nuclear magnetic resonance was used to characterize the Mg 2 Si x Ge 1 - x solid solution. The 2 9 Si isotropic chemical shift changes consistent with the band gap in these materials while the line width increases with local disorder.
Four-electron reduction of metal sulfides by alkynes and the reversible formation of persulfides

Alkynes add to ReS4- to give unstable 1:1 adducts [ReS2(S2C2R2)]-, which have been observed in solution. These mononuclear dithiolenes [ReS2(S2C2R2)]- react further with ReS4- to give the persulfid...
Asymmetric Michael addition reactions of aldehydes with nitrostyrenes catalyzed by functionalized chiral ionic liquids

A new class of pyrrolidine-based functionalized chiral ionic liquids (FCILs) has been developed and shown to be effective and reusable catalysts for the asymmetric Michael addition reactions. For the Michael addition reaction involving various aldehydes and nitrostyrenes, FCIL 6, in combination with trifluoroacetic acid as an additive, was found to be a very effective catalyst, compared to FCIL 3, which varied slightly in structure. Excellent yields (up to 99%), good enantioselectivities (up to 85% ee), and high diastereoselectivities (syn/anti ratio up to 97:3) were obtained for these reactions. The FCIL catalysts were easily recycled and reused for at least five times without significantly losing their ability to affect the outcome of the asymmetric reactions.
Theoretical evaluation of electronic density-of-states and transport effects on field emission from n-type ultrananocrystalline diamond films

In the nitrogen-incorporated ultrananocrystalline diamond [(N)UNCD] films, representing an n-type highly conductive two-phase material comprised of sp3 diamond grains and sp2-rich graphitic grain boundaries, current is carried by a high concentration of mobile electrons within large-volume grain-boundary networks. Fabricated in a simple thin-film planar form, (N)UNCD was found to be an efficient field emitter capable of emitting a significant amount of charge starting at the applied electric field as low as a few volts per micrometer, which makes it a promising material for designing electron sources. Despite semimetallic conduction, field emission (FE) characteristics of this material demonstrate a strong deviation from the Fowler–Nordheim law in a high-current-density regime when (N)UNCD field emitters switch from a diodelike to a resistorlike behavior. Such a phenomenon resembles the current-density saturation effect in conventional semiconductors. In the present paper, we adapt the formalism developed for conventional semiconductors to study current-density saturation in (N)UNCD field emitters. We provide a comprehensive theoretical investigation of (i) partial penetration of the electric field into the material, (ii) transport effects (such as electric-field-dependent mobility), and (iii) features of a complex density-of-states structure (position and shape of π−π∗ bands, controlling the concentration of charge carriers) on the FE characteristics of (N)UNCD. We show that the formation of the current-density saturation plateau can be explained by the limited supply of electrons within the impurity π−π∗ bands and decreasing electron mobility in a high electric field. Theoretical calculations are consistent with the experiment.
Synthesis of 5-Iodo-1,2,3-triazoles from Organic Azides and Terminal Alkynes­: Ligand Acceleration Effect, Substrate Scope, and Mechanistic Insights

An improved method has been developed for the preparation of 5-iodo-1,2,3-triazoles directly from organic azides and terminal alkynes by a reaction mediated by copper(I) and iodinating agents generated in situ. The major methodological advance of the current procedure is that it provides a high conversion and good iodo/proto selectivity with a broad range of substrates without using an excess of the alkyne, which was required in the previous method. The use of an accelerating ligand is essential to the success of reactions involving unreactive azides or alkynes. New mechanistic insights are provided, including the confirmation that a 1-iodoalkyne is formed as a key intermediate under the established conditions for the reaction.
Rapid assembly of structurally defined and highly functionalized conjugated dienes via tethered enyne metathesis.

Conjugated dienes are versatile building blocks in organic synthesis, and the development of new methods for their synthesis remains an important topic in modern synthetic organic chemistry. We describe here an expedient synthesis of highly functionalized conjugated dienes through sequential silicon-tethered ring-closing enyne metathesis mediated by Grubbs' Ru carbene catalysts and Tamao oxidation. Notable attributes of this methodology include short synthetic manipulations and the structural complexity it confers on the resulting diene moiety.
Synthesis of Some Novel Halogenated 2,4-Diaminoquinazolines.

Three new 2,4-diaminoquinazolines, the 5,6-difluoro, 6,7-difluoro and 7,8-difluoro isomers were prepared by the reaction of the requisite trifluorobenzonitrile and guanidine carbonate. Surprisingly, 2,3,6-trifluorobenzonitriles gave 2,4-diamino-5,6-difluoroquinazoline exclusively as determined by high resolution nuclear magnetic resonance spectroscopy. On the other hand, 3-amino-2,6-difluorobenzonitrile on reaction with guanidine carbonate yielded only 5-fluoro-2,4,8-triaminoquinazoline. This compound was subsequently converted to 8-chloro-2,4-diamino-5-fluoroquinazoline using the Sandmeyer procedure. The nitration of 2,4-diamino-8-fluoroquinazoline occurred exclusively at position six yielding 2,4-diamino-8-fluoro-6-nitroquinazoline, which upon reduction with stannous chloride afforded 8-fluoro-2,4,6-triaminoquinazoline. In a similar fashion 7-fluoro-2,4-diaminoquinazoline underwent nitration at position six and was then reduced to give 7-fluoro-2,4,6-triaminoquinazoline. Finally, both of these triaminoquinazolines were converted to the 6-chloro derivatives under Sandmeyer conditions to yield 6-chloro-2,4-diamino-8-fluoroquinazoline and 6-chloro-2,4-diamino-7-fluoroquinazoline, respectively.
From the statistics of connectivity to the statistics of spike times in neuronal networks

An essential step toward understanding neural circuits is linking their structure and their dynamics. In general, this relationship can be almost arbitrarily complex. Recent theoretical work has, however, begun to identify some broad principles underlying collective spiking activity in neural circuits. The first is that local features of network connectivity can be surprisingly effective in predicting global statistics of activity across a network. The second is that, for the important case of large networks with excitatory-inhibitory balance, correlated spiking persists or vanishes depending on the spatial scales of recurrent and feedforward connectivity. We close by showing how these ideas, together with plasticity rules, can help to close the loop between network structure and activity statistics.
A six-step asymmetric synthesis of (+)-hyperaspine.

The ladybird alkaloid, (+)-hyperaspine, has been synthesized in a concise and highly stereoselective manner. The total synthesis was accomplished in six steps and 21% overall yield.
COSMIC ORIGINS SPECTROGRAPH AND FUSE OBSERVATIONS OF T ∼ 10 5 K GAS IN A NEARBY GALAXY FILAMENT ∗

We present a clear detection of a broad Lyα absorber (BLA) with a matching Ovi line in the nearby universe. The BLA is detected at z(Lyα) = 0.01028 in the high signal-to-noise ratio spectrum of Mrk 290 obtained using the Cosmic Origins Spectrograph. The Lyα absorption has two components, with b(Hi) = 55 ± 1k m s −1 and b(Hi) = 33 ± 1k m s −1 , separated in velocity by v ∼ 115 km s −1 .T he Ovi, detected by the Far-Ultraviolet Spectroscopic Explorer at z(Ovi) = 0.01027, has a b(Ovi) = 29 ± 3k m s −1 and is kinematically well aligned with the broader Hi component. The non-detection of other ions such as Cii ,S iii ,F eii ,C iii ,S iiii ,C iv ,S iiv, and Nv at the same velocity as the BLA and the Ovi implies that the absorber is tracing highly ionized gas. The different line widths of the BLA and Ovi suggest a temperature of T = 1.4 × 10 5 K in the absorber. Photoionization, collisional ionization equilibrium as well as non-equilibrium collisional ionization models do not explain the ion ratios at this temperature. The observed line strength ratios and line widths favor an ionization scenario in which both ion–electron collisions and UV photons contribute to the ionization in the gas. Such a model requires a low metallicity of ∼− 1.7 dex, ionization parameter of log U ∼− 1.4, a large total hydrogen column density of N (H) ∼ 4 × 10 19 cm −2 , and a path length of ∼400 kpc. The line of sight to Mrk 290 intercepts at the redshift of the absorber, a megaparsec scale filamentary structure extending over ∼20 ◦ in the sky, with several luminous galaxies distributed within ∼1.5 h −1 Mpc projected distance from the absorber. The collisionally ionized gas phase of this absorber is most likely tracing a shock-heated gaseous structure, consistent with a few different scenarios for the origin including an overdense region of the warm-hot intergalactic medium in the galaxy filament or highly ionized gas in the extended halo of one of the galaxies in the filament. In general, BLAs with metals provide an efficient means to study T ∼ 10 5 –10 6 K gas in galaxy halos and in the intergalactic medium. A substantial fraction of the baryons missing from the present universe is predicted to be in such environments in the form of highly ionized plasma.
Acute Inhibition of Heterotrimeric Kinesin-2 Function Reveals Mechanisms of Intraflagellar Transport in Mammalian Cilia

Summary The trafficking of components within cilia, called intraflagellar transport (IFT), is powered by kinesin-2 and dynein-2 motors. Loss of function in any subunit of the heterotrimeric KIF3A/KIF3B/KAP kinesin-2 motor prevents ciliogenesis in mammalian cells and has hindered an understanding of how kinesin-2 motors function in cilium assembly and IFT. We used a chemical-genetic approach to generate an inhibitable KIF3A/KIF3B/KAP kinesin-2 motor (i3A/i3B) that is capable of rescuing wild-type (WT) motor function for cilium assembly and Hedgehog signaling in Kif3a/Kif3b double-knockout cells. We demonstrate that KIF3A/KIF3B function is required not just for cilium assembly but also for cilium maintenance, as inhibition of i3A/i3B blocks IFT within 2 min and leads to a complete loss of primary cilia within 8 h. In contrast, inhibition of dynein-2 has no effect on cilium maintenance within the same time frame. The kinetics of cilia loss indicate that two processes contribute to ciliary disassembly in response to cessation of anterograde IFT: a slow shortening that is steady over time and a rapid deciliation that occurs with stochastic onset. We also demonstrate that the kinesin-2 family members KIF3A/KIF3C and KIF17 cannot rescue ciliogenesis in Kif3a/Kif3b double-knockout cells or delay the loss of assembled cilia upon i3A/i3B inhibition. These results demonstrate that KIF3A/KIF3B/KAP is the sole and essential motor for cilium assembly and maintenance in mammalian cells. These findings highlight differences in how kinesin-2 motors were adapted for cilium assembly and IFT function across species.
clusterExperiment and RSEC: A Bioconductor package and framework for clustering of single-cell and other large gene expression datasets

Clustering of genes and/or samples is a common task in gene expression analysis. The goals in clustering can vary, but an important scenario is that of finding biologically meaningful subtypes within the samples. This is an application that is particularly appropriate when there are large numbers of samples, as in many human disease studies. With the increasing popularity of single-cell transcriptome sequencing (RNA-Seq), many more controlled experiments on model organisms are similarly creating large gene expression datasets with the goal of detecting previously unknown heterogeneity within cells. It is common in the detection of novel subtypes to run many clustering algorithms, as well as rely on subsampling and ensemble methods to improve robustness. We introduce a Bioconductor R package, clusterExperiment, that implements a general and flexible strategy we entitle Resampling-based Sequential Ensemble Clustering (RSEC). RSEC enables the user to easily create multiple, competing clusterings of the data based on different techniques and associated tuning parameters, including easy integration of resampling and sequential clustering, and then provides methods for consolidating the multiple clusterings into a final consensus clustering. The package is modular and allows the user to separately apply the individual components of the RSEC procedure, i.e., apply multiple clustering algorithms, create a consensus clustering or choose tuning parameters, and merge clusters. Additionally, clusterExperiment provides a variety of visualization tools for the clustering process, as well as methods for the identification of possible cluster signatures or biomarkers. The R package clusterExperiment is publicly available through the Bioconductor Project, with a detailed manual (vignette) as well as well documented help pages for each function.
An efficient synthesis of 1,3-dimethyl-4-(phenylsulfonyl)-4H-furo[3,4-b]indole

(2002). AN EFFICIENT SYNTHESIS OF 1,3-DIMETHYL-4-(PHENYLSULFONYL)-4H-FURO[3,4-b]INDOLE. Organic Preparations and Procedures International: Vol. 34, No. 5, pp. 543-545.
A mild new procedure for production, cyclization and trapping of amidyl radicals: application to a formal total synthesis of peduncularine

Treatment of an olefinic hydroxamic acid with tert-butylsulfinyl chloride and Hunig’s base from −50°C to room temperature in the presence of a radical trap such as diphenyl diselenide, diphenyl disulfide or TEMPO affords a functionalized product derived from an amidyl radical cyclization. The methodology has been used in a formal total synthesis of the 6-azabicyclo[3.2.1]octane-containing indole alkaloid peduncularine.
Distributed Wideband Sensing-Based Architecture for Unlicensed Massive IoT Communications

Providing Internet connectivity to a massive number of Internet-of-Things (IoT) objects over the unlicensed spectrum requires: 1) identifying a very large number of narrowband channels in a wideband spectrum and 2) aggressively reusing the available channels over space to accommodate the high density of IoT devices. To this end, we propose a sensing-based architecture that identifies spectral and spatial resources at a fine resolution. In particular, we first propose a sensing assignment scheduler, where each base station (BS) is assigned a subset of the spectrum to sense at a high resolution. We then propose a distributed sensing algorithm, where BSs locally process and share their sensing reports, so that each BS obtains occupancy information of the wideband spectrum at its location. Once the spatio-spectral resource blocks are identified, we further propose a distributed resource allocation algorithm that maintains high spatial reuse of spectral opportunities while limiting the intra-network and inter-network interference. Numerical simulations are presented to validate the effectiveness of the proposed distributed algorithms, comparing them to centralized and non-cooperative schemes. It is shown that our architecture identifies more spatio-spectral resources, with lower misdetection of incumbents. As a result, more IoT devices are connected with limited interference into incumbents.
Direct approaches to annulated indoles. A formal total synthesis of 0231B

An advanced intermediate in the Nakatsuka synthesis of 0231B was prepared using a fluoride-mediated indole formation in the key step. Both palladium-based approaches and hydride-based approaches failed to generate the indole.
Demystifying excessively volatile human learning: A Bayesian persistent prior and a neural approximation.

Understanding how humans and animals learn about statistical regularities in stable and volatile environments, and utilize these regularities to make predictions and decisions, is an important problem in neuroscience and psychology. Using a Bayesian modeling framework, specifically the Dynamic Belief Model (DBM), it has previously been shown that humans tend to make the {\it default} assumption that environmental statistics undergo abrupt, unsignaled changes, even when environmental statistics are actually stable. Because exact Bayesian inference in this setting, an example of switching state space models, is computationally intense, a number of approximately Bayesian and heuristic algorithms have been proposed to account for learning/prediction in the brain. Here, we examine a neurally plausible algorithm, a special case of leaky integration dynamics we denote as EXP (for exponential filtering), that is significantly simpler than all previously suggested algorithms except for the delta-learning rule, and which far outperforms the delta rule in approximating Bayesian prediction performance. We derive the theoretical relationship between DBM and EXP, and show that EXP gains computational efficiency by foregoing the representation of inferential uncertainty (as does the delta rule), but that it nevertheless achieves near-Bayesian performance due to its ability to incorporate a "persistent prior" influence unique to DBM and absent from the other algorithms. Furthermore, we show that EXP is comparable to DBM but better than all other models in reproducing human behavior in a visual search task, suggesting that human learning and prediction also incorporates an element of persistent prior. More broadly, our work demonstrates that when observations are information-poor, detecting changes or modulating the learning rate is both {\it difficult} and (thus) {\it unnecessary} for making Bayes-optimal predictions.
Chiral silanes via asymmetric hydrosilylation with catalytic CuH

[reaction: see text] CuH-catalyzed asymmetric conjugate reduction of beta-silyl-alpha,beta-unsaturated esters has been developed. Using PMHS as a stoichiometric source of hydride and in situ generated CuH ligated by Solvias' JOSIPHOS analogue PPF-P(t-Bu)(2) leads to highly enantioselective 1,4-reductions.
Nucleophilic trifluoromethylation and difluorination of substituted aromatic aldehydes with Ruppert’s and Deoxofluor™ reagents

Efficient, high yield syntheses of 2,2,2-trifluoro-1-(N,N-dialkylaminophenyl)-ethanols (3a, b) and 2,2,2-trifluoro-1-(hydroxyaryl)ethanols (6c–g) by reacting Ruppert’s reagent, (trifluoromethyl)trimethylsilane (TMSCF3), with appropriate substrates in the presence of a catalytic amount of cesium fluoride are described. A versatile route to the synthesis of substituted aryl difluoromethane derivatives (8h–l, 10m, 12n, o, 14p) and the reactivity of substituted aromatic aldehydes towards bis(2-methoxyethyl)aminosulfur trifluoride (Deoxofluor™) were also investigated.
Ketamine disrupts neuromodulatory control of glutamatergic synaptic transmission

A growing body of literature has demonstrated the potential for ketamine in the treatment of major depression. Sub-anesthetic doses produce rapid and sustained changes in depressive behavior, both in patients and rodent models, associated with reorganization of glutamatergic synapses in the prefrontal cortex (PFC). While ketamine is known to regulate N-methyl-D-aspartate (NMDA) -type glutamate receptors (NMDARs), the full complement of downstream cellular consequences for ketamine administration are not well understood. Here, we combine electrophysiology with 2-photon imaging and glutamate uncaging in acute slices of mouse PFC to further examine how ketamine alters glutamatergic synaptic transmission. We find that four hours after ketamine treatment, glutamatergic synapses themselves are not significantly affected. However, levels of the neuromodulatory Regulator of G-protein Signaling (RGS4) are dramatically reduced. This loss of RGS4 activity is associated with disruption of the normal compartmentalization of synaptic neuromodulation. Thus, under control conditions, α2 adrenergic receptors and type B γ-aminobutyric acid (GABAB) receptors selectively inhibit α-amino-3-hydroxy-5-methyl-4-isoxazolepropionic acid (AMPA) -type glutamate receptors (AMPARs) and NMDARs, respectively. After ketamine administration and reduction in RGS4 activity, this selectivity is lost, with both modulatory systems broadly inhibiting glutamatergic transmission. These results suggest a novel mechanism by which ketamine may influence synaptic signaling and provide new avenues for the exploration of therapeutics directed at treating neuropsychiatric disorders, such as depression.
High-throughput identification of dominant negative polypeptides in yeast

Dominant negative polypeptides can inhibit protein function by binding to a wild-type subunit or by titrating a ligand. Here we use high-throughput sequencing of libraries composed of fragments of yeast genes to identify polypeptides that act in a dominant negative manner, in that they are depleted during cell growth. The method can uncover numerous inhibitory polypeptides for a protein and thereby define small inhibitory regions, even pinpointing individual residues with critical functional roles.
Magnetoresistance, Micromagnetism, and Domain Wall Effects in Epitaxial Fe and Co Structures with Stripe Domains

We review our recent magnetotransport and micromagnetic studies of lithographically defined epitaxial thin film structures of bcc Fe and hcp Co with stripe domains. Micromagnetic structure and resistivity anisotropy are shown to be the predominant sources of low field magnetoresistance (MR) in these microstructures, with domain wall (DW) effects smaller but observable (DW-MR $\lesssim 1 %$). In Fe, at low temperature, in a regime in which fields have a significant effect on electron trajectories, a novel negative DW contribution to the resistivity is observed. In hcp Co microstructures, temperature dependent transport measurements for current perpendicular and parallel to walls show that any additional resistivity due to DW scattering is very small.
Reversible Friedel-Crafts acylations of 3-alkyl-1-(phenylsulfonyl)pyrroles: Application to the synthesis of an ant trail pheromone

Abstract Friedel-Crafts acylations of 3-alkyl-1-(phenylsulfonyl)pyrroles appear to be kinetically favored at the adjacent C-2 position but rearrangement to the C-5 position can occur after prolonged reaction times. This reversible Friedel-Crafts methodology has been employed for the synthesis of the ant trail pheromone, methyl 4-methylpyrrole-2-carboxylate.
Internal Gain Modulations, But Not Changes in Stimulus Contrast, Preserve the Neural Code.

Neurons in primary visual cortex are strongly modulated both by stimulus contrast and by fluctuations of internal inputs. An important question is whether the population code is preserved under these conditions. Changes in stimulus contrast are thought to leave the population code invariant, whereas the effect of internal gain modulations remains unknown. To address these questions we studied how the direction-of-motion of oriented gratings is encoded in layer 2/3 primary visual cortex of mouse (with C57BL/6 background, of either sex). We found that, because contrast gain responses across cells are heterogeneous, a change in contrast alters the information distribution profile across cells leading to a violation of contrast invariance. Remarkably, internal input fluctuations that cause commensurate firing rate modulations at the single-cell level result in more homogeneous gain responses, respecting population code invariance. These observations argue that the brain strives to maintain the stability of the neural code in the face of fluctuating internal inputs. SIGNIFICANCE STATEMENT Neuronal responses are modulated both by stimulus contrast and by the spontaneous fluctuation of internal inputs. It is not well understood how these different types of input impact the population code. Specifically, it is important to understand whether the neural code stays invariant in the face of significant internal input modulations. Here, we show that changes in stimulus contrast lead to different optimal population codes, whereas spontaneous internal input fluctuations leave the population code invariant. This is because spontaneous internal input fluctuations modulate the gain of neuronal responses more homogeneously across cells compared to changes in stimulus contrast.
GALACTIC TWINS OF THE RING NEBULA AROUND SN1987A AND A POSSIBLE LBV-LIKE PHASE FOR SK-69 202

Resumen en: Some core-collapse supernovae show clear signs of interaction with dense circumstellar material that often appears to be non-spherical. Circumstellar neb...
Visual-Olfactory Integration in the Human Disease Vector Mosquito Aedes aegypti

Mosquitoes rely on the integration of multiple sensory cues, including olfactory, visual, and thermal stimuli, to detect, identify, and locate their hosts [1-4]. Although we increasingly know more about the role of chemosensory behaviors in mediating mosquito-host interactions [1], the role of visual cues is comparatively less studied [3], and how the combination of olfactory and visual information is integrated in the mosquito brain remains unknown. In the present study, we used a tethered-flight light-emitting diode (LED) arena, which allowed for quantitative control over the stimuli, and a control theoretic model to show that CO2 modulates mosquito steering responses toward vertical bars. To gain insight into the neural basis of this olfactory and visual coupling, we conducted two-photon microscopy experiments in a new GCaMP6s-expressing mosquito line. Imaging revealed that neuropil regions within the lobula exhibited strong responses to objects, such as a bar, but showed little response to a large-field motion. Approximately 20% of the lobula neuropil we imaged were modulated when CO2 preceded the presentation of a moving bar. By contrast, responses in the antennal (olfactory) lobe were not modulated by visual stimuli presented before or after an olfactory stimulus. Together, our results suggest that asymmetric coupling between these sensory systems provides enhanced steering responses to discrete objects.
Locality-sensitive hashing for the edit distance.

MOTIVATION Sequence alignment is a central operation in bioinformatics pipeline and, despite many improvements, remains a computationally challenging problem. Locality-sensitive hashing (LSH) is one method used to estimate the likelihood of two sequences to have a proper alignment. Using an LSH, it is possible to separate, with high probability and relatively low computation, the pairs of sequences that do not have high-quality alignment from those that may. Therefore, an LSH reduces the overall computational requirement while not introducing many false negatives (i.e. omitting to report a valid alignment). However, current LSH methods treat sequences as a bag of k-mers and do not take into account the relative ordering of k-mers in sequences. In addition, due to the lack of a practical LSH method for edit distance, in practice, LSH methods for Jaccard similarity or Hamming similarity are used as a proxy. RESULTS We present an LSH method, called Order Min Hash (OMH), for the edit distance. This method is a refinement of the minHash LSH used to approximate the Jaccard similarity, in that OMH is sensitive not only to the k-mer contents of the sequences but also to the relative order of the k-mers in the sequences. We present theoretical guarantees of the OMH as a gapped LSH. AVAILABILITY AND IMPLEMENTATION The code to generate the results is available at http://github.com/Kingsford-Group/omhismb2019. SUPPLEMENTARY INFORMATION Supplementary data are available at Bioinformatics online.
Comparing online community structure of patients of chronic diseases

In this paper, we use social media as a mirror to understand hidden characteristics of patients of chronic diseases, who are expressing themselves on Twitter, Facebook, and in online forums. We compare the social network structure and emotionality of people talking about Crohn's disease, cystic fibrosis, and Type 1 diabetes. We find that the Crohn's community's contributors are most negative on social media, while patients of cystic fibrosis are surprisingly positive. We also notice more centralised network structure of Twitter retweet networks and Facebook wall post networks for cystic fibrosis and Crohn's than for Type 1 diabetes. This might indicate the strong leadership role played by their national foundations, Crohn's and Colitis Foundation of America (CCFA) and Cystic Fibrosis Foundation (CFF).
f-Biharmonic maps and f-biharmonic submanifolds II

Abstract We continue our study [9] of f -biharmonic maps and f -biharmonic submanifolds by exploring the applications of f -biharmonic maps and the relationships among biharmonicity, f -biharmonicity and conformality of maps between Riemannian manifolds. We are able to characterize harmonic maps and minimal submanifolds by using the concept of f -biharmonic maps and prove that the set of all f -biharmonic maps from 2-dimensional domain is invariant under the conformal change of the metric on the domain. We give an improved equation for f -biharmonic hypersurfaces and use it to prove some rigidity theorems about f -biharmonic hypersurfaces in nonpositively curved manifolds, and to give some classifications of f -biharmonic hypersurfaces in Einstein spaces and in space forms. Finally, we also use the improved f -biharmonic hypersurface equation to obtain an improved equation and some classifications of biharmonic conformal immersions of surfaces into a 3-manifold.
Gaussian Fluctuations for Linear Eigenvalue Statistics of Products of Independent iid Random Matrices

Consider the product $$X = X_{1}\cdots X_{m}$$ of m independent $$n\times n$$ iid random matrices. When m is fixed and the dimension n tends to infinity, we prove Gaussian limits for the centered linear spectral statistics of X for analytic test functions. We show that the limiting variance is universal in the sense that it does not depend on m (the number of factor matrices) or on the distribution of the entries of the matrices. The main result generalizes and improves upon previous limit statements for the linear spectral statistics of a single iid matrix by Rider and Silverstein as well as Renfrew and the second author.
Acoustic Feature Learning Using Cross-Domain Articulatory Measurements

Previous work has shown that it is possible to improve speech recognition by learning acoustic features from paired acoustic-articulatory data, for example by using canonical correlation analysis (CCA) or its deep extensions. One limitation of this prior work is that the learned feature models are difficult to port to new datasets or domains, and articulatory data is not available for most speech corpora. In this work we study the problem of acoustic feature learning in the setting where we have access to an external, domain-mismatched dataset of paired speech and articulatory measurements, either with or without labels. We develop methods for acoustic feature learning in these settings, based on deep variational CCA and extensions that use both source and target domain data and labels. Using this approach, we improve phonetic recognition accuracies on both TIMIT and Wall Street Journal and analyze a number of design choices.
Simulation of Phonon-Polariton Generation and Propagation in Ferroelectric LiNbO3 Crystals

We simulate propagation of phonon-polaritons (admixtures of polar lattice vibrations and electromagnetic waves) in ferroelectric LiNbO3 with a model that consists of a spatially periodic array of harmonic oscillators coupled to THz electromagnetic waves through an electric dipole moment. We show that when this model is combined with the auxiliary differential equation method of finite difference time domain (FDTD) simulations, the salient features of phonon-polaritons may be illustrated. Further, we introduce second order nonlinear coupling to an optical field to demonstrate phonon-polariton generation by impulsive stimulated Raman scattering (ISRS). The phonon-polariton dispersion relation in bulk ferroelectric LiNbO3 is determined from simulation.
Double Hall algebras and derived equivalences

Abstract We show that the reduced Drinfeld double of the Ringel–Hall algebra of a hereditary category is invariant under derived equivalences. By associating an explicit isomorphism to a given derived equivalence, we also extend the results of Burban and Schiffmann [5] , [6] , Sevenhant and Van den Bergh (1999) [25] , and Xiao and Yang (2001) [31] .
Multilayer microwave integrated quantum circuits for scalable quantum computing

As experimental quantum information processing (QIP) rapidly advances, an emerging challenge is to design a scalable architecture that combines various quantum elements into a complex device without compromising their performance. In particular, superconducting quantum circuits have successfully demonstrated many of the requirements for quantum computing, including coherence levels that approach the thresholds for scaling. However, it remains challenging to couple a large number of circuit components through controllable channels while suppressing any other interactions. We propose a hardware platform intended to address these challenges, which combines the advantages of integrated circuit fabrication and the long coherence times achievable in three-dimensional circuit quantum electrodynamics. This multilayer microwave integrated quantum circuit platform provides a path towards the realisation of increasingly complex superconducting devices in pursuit of a scalable quantum computer.
On Saito’s vanishing theorem

We reprove Saito's vanishing theorem for mixed Hodge modules by the method of Esnault and Viehweg. The main idea is to exploit the strictness of direct images on certain branched coverings.
Bounded Namba forcing axiom may fail

In a sigma-closed forcing extension, the bounded forcing axiom for Namba forcing fails. This answers a question of Justin Tatch Moore.
Intercalation Driven Porosity Effects in Coupled Continuum Models for the Electrical, Chemical, Thermal and Mechanical Response of Battery Electrode Materials

We present a coupled continuum formulation for the electrostatic, chemical, thermal and mechanical processes in battery materials. Our treatment applies on the macroscopic scale, at which electrodes can be modeled as porous materials made up of active particles held together by binders and perfused by the electrolyte. Starting with the description common to the field, in terms of reaction-transport partial differential equations for ions, variants of the classical Poisson equation for electrostatics, and the heat equation, we add mechanics to the problem. Our main contribution is to model the evolution of porosity as a consequence of strains induced by intercalation, thermal expansion and mechanical stresses. Recognizing the potential for large local deformations, we have settled on the finite strain framework. We present a detailed computational study of the influence of the dynamically evolving porosity, upon ion distribution, electrostatic potential fields, charge-discharge cycles and mechanical force generated in the cell.