In Brief: Antifungal Drugs

1. Lynn Smitherman, MD* 1. *Wayne State University School of Medicine, Detroit, MI. 1. 1. Tay E. Azole Antifungal Agents. Tay E. Pediatr Rev. 2005;26(1):20–21 [OpenUrl][1][FREE Full Text][2] 2. 1. Jura S, 2. Hillenbrand K. Fluconazole. Jura S, Hillenbrand K. Pediatr Rev. 2006;27(4):158–159 [OpenUrl][3][FREE Full Text][4] 3. 1. Abadi J. Amphotericin B. Abadi J. Pediatr Rev. 1995;16(10):263–264 [OpenUrl][5] 4. 1. Kelly BP. Superficial Fungal Infections. Kelly BP. Pediatr Rev. 2012;33(4):e22–e36 [OpenUrl][6][FREE Full Text][7] 5. 1. Kimberlin DW, 2. Brady MT, 3. Jackson MA, 4. Long SS Antifungal Drugs for Systemic Fungal Infections. In: Kimberlin DW, Brady MT, Jackson MA, Long SS, eds. Red Book 2015. Elk Grove Village, IL: American Academy of Pediatrics; 2015:905–907 Fungi cause both superficial and serious systemic infections in children. Eradication of fungal infections typically involves the use of agents that inhibit cell membrane function, leading to cell death. Selection of the appropriate medication for fungal infections depends on the susceptibility of the organism and the adverse effects of the drug. The major classes of systemic antifungal agents are polyenes, azoles, and echinocandins. The most commonly used polyene is amphotericin B. Since 1960, this product of the actinomycete Streptomyces nodosus has been widely used for systemic infections against a broad array of fungal species. Amphotericin B deoxycholate, the conventional formulation of this drug, remains the preferred treatment for newborns with systemic candidiasis because of its better penetration into the central nervous system, urinary tract, and eye. However, potential adverse reactions, particularly renal toxicity, necessitate close monitoring. Lipid-associated and liposomal formulations of amphoterin B are less … [1]: {openurl}?query=rft.jtitle%253DPediatrics%2Bin%2BReview%26rft.stitle%253DPediatr.%2BRev.%26rft.aulast%253DTay%26rft.auinit1%253DE.%2BT.%26rft.volume%253D26%26rft.issue%253D1%26rft.spage%253D20%26rft.epage%253D21%26rft.atitle%253DAzole%2BAntifungal%2BAgents%26rft_id%253Dinfo%253Adoi%252F10.1542%252Fpir.26-1-20%26rft.genre%253Darticle%26rft_val_fmt%253Dinfo%253Aofi%252Ffmt%253Akev%253Amtx%253Ajournal%26ctx_ver%253DZ39.88-2004%26url_ver%253DZ39.88-2004%26url_ctx_fmt%253Dinfo%253Aofi%252Ffmt%253Akev%253Amtx%253Actx [2]: /lookup/ijlink?linkType=FULL&journalCode=pedsinreview&resid=26/1/20&atom=%2Fpedsinreview%2F37%2F6%2F267.atom [3]: {openurl}?query=rft.jtitle%253DPediatrics%2Bin%2BReview%26rft.stitle%253DPediatr.%2BRev.%26rft.aulast%253DJura%26rft.auinit1%253DS.%2BE.%26rft.volume%253D27%26rft.issue%253D4%26rft.spage%253D158%26rft.epage%253D159%26rft.atitle%253DFluconazole%26rft_id%253Dinfo%253Adoi%252F10.1542%252Fpir.27-4-158%26rft_id%253Dinfo%253Apmid%252F16581959%26rft.genre%253Darticle%26rft_val_fmt%253Dinfo%253Aofi%252Ffmt%253Akev%253Amtx%253Ajournal%26ctx_ver%253DZ39.88-2004%26url_ver%253DZ39.88-2004%26url_ctx_fmt%253Dinfo%253Aofi%252Ffmt%253Akev%253Amtx%253Actx [4]: /lookup/ijlink?linkType=FULL&journalCode=pedsinreview&resid=27/4/158&atom=%2Fpedsinreview%2F37%2F6%2F267.atom [5]: {openurl}?query=rft.jtitle%253DPediatr%2BRev.%26rft.volume%253D16%26rft.spage%253D263%26rft.genre%253Darticle%26rft_val_fmt%253Dinfo%253Aofi%252Ffmt%253Akev%253Amtx%253Ajournal%26ctx_ver%253DZ39.88-2004%26url_ver%253DZ39.88-2004%26url_ctx_fmt%253Dinfo%253Aofi%252Ffmt%253Akev%253Amtx%253Actx [6]: {openurl}?query=rft.jtitle%253DPediatrics%2Bin%2BReview%26rft.stitle%253DPediatr.%2BRev.%26rft.aulast%253DKelly%26rft.auinit1%253DB.%2BP.%26rft.volume%253D33%26rft.issue%253D4%26rft.spage%253De22%26rft.epage%253De37%26rft.atitle%253DSuperficial%2BFungal%2BInfections%26rft_id%253Dinfo%253Adoi%252F10.1542%252Fpir.33-4-e22%26rft_id%253Dinfo%253Apmid%252F22474120%26rft.genre%253Darticle%26rft_val_fmt%253Dinfo%253Aofi%252Ffmt%253Akev%253Amtx%253Ajournal%26ctx_ver%253DZ39.88-2004%26url_ver%253DZ39.88-2004%26url_ctx_fmt%253Dinfo%253Aofi%252Ffmt%253Akev%253Amtx%253Actx [7]: /lookup/ijlink?linkType=FULL&journalCode=pedsinreview&resid=33/4/e22&atom=%2Fpedsinreview%2F37%2F6%2F267.atom