cssi/SciSciGPT-SciSciNet huggingface dataset:
Evidence for CDK-Dependent and CDK-Independent Functions of the Murine Gammaherpesvirus 68 v-Cyclin

Gamma-2 herpesviruses encode homologues of mammalian D-type cyclins (v-cyclins), which likely function to manipulate the cell cycle, thereby providing a cellular environment conducive to virus replication and/or reactivation from latency. We have previously shown that the v-cyclin of murine gammaherpesvirus 68 is an oncogene that binds and activates cellular cyclin-dependent kinases (CDKs) and is required for efficient reactivation from latency. To determine the contribution of v-cyclin-mediated cell cycle regulation to the viral life cycle, recombinant viruses in which specific point mutations (E133V or K104E) were introduced into the v-cyclin open reading frame were generated, resulting in the disruption of CDK binding and activation. While in vitro growth of these mutant viruses was unaffected, lytic replication in the lungs following low-dose intranasal inoculation was attenuated for both mutants deficient in CDK binding as well as virus in which the entire v-cyclin open reading frame was disrupted by the insertion of a translation termination codon. This replication defect was not apparent in spleens of mice following intraperitoneal inoculation, suggesting a cell type- and/or route-specific dependence on v-cyclin-CDK interactions during the acute phase of virus infection. Notably, although a v-cyclin-null virus was highly attenuated for reactivation from latency, the E133V v-cyclin CDK-binding mutant exhibited only a modest defect in virus reactivation from splenocytes, and neither the E133V nor K104E v-cyclin mutants were compromised in reactivation from peritoneal exudate cells. Taken together, these data suggest that lytic replication and reactivation in vivo are differentially regulated by CDK-dependent and CDK-independent functions of v-cyclin, respectively.
Physical activity, participation in team sports, and risk of suicidal behavior in adolescents

Suicide is the second-leading cause of death in adolescents. ] Suicide rates in 1990 for youth aged 15 to 19 were 18.1 per 100,000 for boys and 3.7 per 100,000 for girls; although girls attempt suicide more often than boys, boys more frequently succeed in their suicide attempts. 2 Nearly one-third of all students in grades 9 through 12 in 1991 had seriously thought about committing suicide, 16% had made a specific plan to commit suicide, and 8% had actually attempted suicide) Because suicidal thoughts and suicide attempts are so prevalent in adolescents, it is important to understand the correlates and predictors of suicidal behavior as well as the factors that may protect adolescents against suicidal behavior. If these risk and protective factors can be identified, it may be possible to identify those adolescents at high risk of attempting suicide or to design school-based suicide prevention programs targeted toward all students. Physical activity is positively associated with self-esteem, well-being, and self-efficacy 4 and negatively associated with depression, 5 anxiety, 6 loneliness, shyness, and hopelesshess. 7 Psychological treatment programs for adolescents 5,s,9
Reck enables cerebrovascular development by promoting canonical Wnt signaling.

The cerebral vasculature provides the massive blood supply that the brain needs to grow and survive. By acquiring distinctive cellular and molecular characteristics it becomes the blood-brain barrier (BBB), a selectively permeable and protective interface between the brain and the peripheral circulation that maintains the extracellular milieu permissive for neuronal activity. Accordingly, there is great interest in uncovering the mechanisms that modulate the formation and differentiation of the brain vasculature. By performing a forward genetic screen in zebrafish we isolated no food for thought (nft (y72)), a recessive late-lethal mutant that lacks most of the intracerebral central arteries (CtAs), but not other brain blood vessels. We found that the cerebral vascularization deficit of nft (y72) mutants is caused by an inactivating lesion in reversion-inducing cysteine-rich protein with Kazal motifs [reck; also known as suppressor of tumorigenicity 15 protein (ST15)], which encodes a membrane-anchored tumor suppressor glycoprotein. Our findings highlight Reck as a novel and pivotal modulator of the canonical Wnt signaling pathway that acts in endothelial cells to enable intracerebral vascularization and proper expression of molecular markers associated with BBB formation. Additional studies with cultured endothelial cells suggest that, in other contexts, Reck impacts vascular biology via the vascular endothelial growth factor (VEGF) cascade. Together, our findings have broad implications for both vascular and cancer biology.
A primer on regeneration

Centuries of observation have uncovered a diverse range of organisms capable of overcoming loss of tissue. The act of restoring lost anatomy and function is known as regeneration, and it is broadly represented in both plant and animal kingdoms. Cumulative studies have identified a series of events that take place during regeneration of complex animal structures. First, the organism recognizes damage and undergoes wound healing. Then, programmed cell death in the vicinity of the damaged tissue precedes proliferation and migration of cells that foster the development of replacement tissue. Finally, rearrangement of pre-existing tissue and integration with newly differentiated cells take place to restore the function and proportionality displayed previous to damage . Although the ability to regenerate is believed to be ancestrally common and lost throughout evolution, there is significant heterogeneity of some basic mechanisms displayed during regeneration in different animal species. Perhaps one of the most noticeable differences is the cellular source contributing to formation of the new tissue during regeneration. Organisms such as planarians and Hydra rely on active reservoirs of somatic pluripotent stem cells abundantly distributed throughout their bodies and maintained throughout their life. On the other hand, vertebrates rely mostly on progenitor cell activation and dedifferentiation, to regenerate cells with limited potential to regenerate specific structures. However, not all regenerative events rely on cellular replacement. Leading edge research has begun to uncover mechanisms involved in autonomous repair and functional regeneration of single cells – be it neurons or ciliated protozoa. The fact that organisms can achieve regeneration through diverse cellular sources is remarkable, but just as remarkable is the possibility that conserved molecular pathways could be activated to achieve regeneration in different species. Analysis of these pathways will contribute to understanding human development and potential avenues for regenerative medicine.
Therapy for Acute Coronary Syndrome and Unstable Angina

Non-ST-segment elevation acute coronary syndromes (NSTE ACS) include unstable angina (UA) and non-ST-segment elevation myocardial infarction (NSTEMI). The significant morbidity and mortality associated with NSTE ACS have motivated decades of drug development and clinical investigation, with considerable emphasis on the central role of the platelet in the pathophysiology and treatment of these disease processes. This chapter offers a broad overview of the pharmacologic treatment of NSTE ACS, with an emphasis on (1) antiplatelet agents, including low-dose aspirin, second- and third-generation P2Y12 receptor blockers, and glycoprotein IIb/IIIa receptor inhibitors; (2) anticoagulant therapy, including unfractionated heparin, enoxaparin, fondaparinux, and bivalirudin; and (3) other pharmacologic agents, including beta-blockers, nitrates, calcium channel blockers, and statins which are also used in the acute management of NSTE ACS.
1 Thessalonians 4.13–18 in Rabbinic Perspective

1 Thessalonians 4.16–17 has occasioned much scholarly speculation regarding Paul's conception of the resurrected body, the character of those caught up in Christ, the ultimate fate of those who are caught up in the air, and Pauline eschatology in general. The interpretation of the passage may be illuminated by comparison with rabbinic traditions in which the righteous escape judgment and destruction in Sheol by flying and being borne aloft by clouds, traditions that, given Paul's Jewish heritage, could well stand in the background of 1 Thess 4.16–17.
Efficient finite element modeling of thin-walled structures with constrained viscoelastic layer damping

A finite elements technique is developed and demonstrated as an efficient and accurate method for optimizing constrained viscoelastic layer damping applications. Special attention is given to composite constraining layers and the importance of their fiber orientation. Experimental results are presented that verify the analytical trends for a simple uniformly treated cantilever beam and for an angled cantilever panel. Computational results are given for a clampedclamped-free-free panel in transverse vibration.
Kepone distribution in selected tissues of blue crabs,Callinectes sapidus, collected from the James River and lower Chesapeake Bay

Male, ovigerous female and nonovigerous female blue crabs were collected from seven stations in the lower Chesapeake Bay and lower James River, Virginia. The Kepone concentration in muscle, gonad and hepatopancreas was determined by GC analysis. All crabs from the lower Bay contained little Kepone, while many of those from the lower James River were contaminated. Male crabs contained more Kepone in the backfin muscle than females. Female crabs concentrated Kepone into the gonad, and, to a lesser extent, the hepatopancreas whereas the males did not. Ovigerous female crabs with spent ovaries, had less Kepone in the ovary than the corresponding egg masses. Further, ovigerous females, especially those with spent ovaries, had more Kepone in backfin muscle than nonovigerous females. It is concluded that the differences in Kepone partitioning among tissues of male and female crabs may explain the previously reported observation that males contain more Kepone in the backfin muscle than do females.
Breeding and Utilization of New Restorer Line 08 with Good Grain Quality in Rice

08 is a thermo-sensitive medium maturity and fine-quality rice restorer line,which is derived from the cross of the restorer line Gui 227 or Qiguizhan as male and Youzhan 8 as female and developed by the Guangxi Rice Research Institute.It is characteristic of good plant type,strong tillering ability,heavy pollen load,good disease resistances,high combining ability,strong restoring ability,good grain quality and medium maturity.Among its hybrids,Qiyou 08 showed high-yielding ability,good grain quality and medium maturity and was certified and registered by the Guangxi Zhuang Autonomous Region Crop Variety Appraisal Committee in 2006.
Countermeasures on Bidirectional Influence between Transportation and Tourism——A Case Study of Regional Transportation Changes in Yichang City

The relationships between transportation and tourism were mutual promotion and mutual influence. Transportation affected on tourism in the tourist flow, tourist resources development, tourism image and tourism economic development. Tourism affected transportation on the transportation economic, traffic operation, traffic quality and traffic patterns. Taking Yichang City in Hubei Provence as a case study, this paper analyzed the bidirectional influence between the transportation and tourism based on the changes of regional transportation, such as the spatial pattern, passenger market,product mix, and industrial structure. Finally, some countermeasures between transportation and tourism were put forward.
Analysis of treatment status of patients with type 2 diabetes complicated with hypertension in Jiading District,Shanghai

AIM: To investigate the treatment status of patients with type 2 diabetes complicated with hypertension in Jiading District,Shanghai. METHODS: A questionnaire and physical and laboratory examinations were conducted in 423 patients with type 2 diabetes complicated with hypertension. Patients were selected using multistage stratified random sampling method in four communities. RESULTS: In the 413 patients with complete data,90. 8% patients were undergoing treatment with antihypertensive drugs and the control rate of blood pressure was 26. 9%. Two hundred and seventy-eight patients( 71. 4%) took only one type of antihypertensive drug; 86. 9% patients had regular hypoglycemic drugs and blood glucose control rate was 69. 4%. Hypercholesterolemia,left ventricular hypertrophy and peripheral arterial disease were risk factors for poor control of blood pressure,and long years of diabetes,irregular use of anti-diabetic drugs,hypertriglyceridemia and high low-density lipoprotein were risk factors for poor control of blood glucose. CONCLUSION: Standardized drug-taking rate in patients with type 2diabetes complicated with hypertension in Jiading District is 86. 9%. Blood glucose control rate is 69. 4%but blood pressure control rate is only 26. 9%. Hyperlipidemia and irregular drug taking are the independent controllable factors for blood pressure control and blood glucose control.
Loss of suppression of GSH synthesis at low cell density in primary cultures of rat hepatocytes

Primary cultures of adult rat hepatocytes shift into the growth phase when plated at low density (LD). We used this model to examine changes in glutathione (GSH) metabolism, since cells undergoing active growth may be more susceptible to environmental toxins. When primary cultures of adult rat hepatocytes were plated on collagen or Matrigel-precoated dishes, cell number and GSH varied inversely. This density effect on cell GSH occurred as early as 2 h after plating, when the media contained 1 mM methionine, but was delayed until 20 h if the media contained only 0.5 mM cystine. The density effect on GSH synthesis occurred in the absence of serum, hormones, changes in cell volume, GSH efflux, ATP levels, and uptake of methionine or cystine and was blocked by cycloheximide or actinomycin D. When methionine was available, the cellular cysteine level was 65% higher at LD than at high density (HD). gamma-Glutamylcysteine synthetase (GCS) activity was 64% higher at LD than at HD. GSH synthetase activity was unaffected by density. Both the increase in cellular cysteine levels and GCS activity were blocked by cycloheximide and actinomycin D. When cells were cocultured using cluster plates and Transwell inserts for 4 h, cell GSH of HD cells was unaffected by the density of cocultured cells; however, LD cells exhibited significantly lower GSH and GCS activity when cocultured with HD cells than when cocultured with LD cells. Cysteine levels were elevated in the LD cells regardless of the density of cocultured cells.(ABSTRACT TRUNCATED AT 250 WORDS)
Regulation of erythropoiesis in long-term hamster marrow cultures: role of bone marrow-adherent cells

The initial establishment of hamster long-term bone marrow (LTBM) cultures requires formation of an adherent stromal layer, but continued long-term proliferation of these cultures is best accomplished by removal of the suspension cells from the adherent layer and subsequent incubation in liquid suspension culture. Continued maintenance of bone marrow cells in the presence of the adherent layer for more than four to six weeks leads to a decline and eventual disappearance of erythroid and multipotent colony-forming cells. Addition of erythropoietin to LTBM suspension cultures produces mature, hemoglobinized erythrocytes. Incubation of the same cells plus erythropoietin in the presence of autologous parental adherent layers markedly inhibits both terminal erythroid differentiation and the number of detectable erythroid burst- forming units (BFU-Es). This erythroid inhibition occurs primarily within the first 24 hours with little or no effect on CFU-GEMMs or granulocyte-macrophage colony-forming units (GM-CFUs). However, continued incubation for seven days produces a reduction in all parameters. Removal of suspension cells from the adherent layer and restimulation with erythropoietin allows regeneration of erythropoiesis. Pretreatment of suspension cells with erythropoietin for 96 hours before exposure to the adherent culture only slightly inhibits erythropoiesis, suggesting that more mature erythroid progenitors are unaffected. Conditioned medium from the marrow adherent layer (ALCM) produces similar erythroid inhibitory effects in LTBM cultures with as little as two hours of incubation. The inhibition is actively produced by the adherent cells, since cycloheximide abolishes its production, while indomethacin has no apparent effect. Adherent marrow stromal cells may regulate hemopoiesis through negative as well as positive humoral signals, and they are particularly effective in erythroid regulation.
Boys like to make noise: A continuing professional development article helped Serena Ansell care for a boy with a tracheostomy

I work as a part-time school nurse in a special needs school. Last summer provided a few days respite care for a student who has a tracheostomy, so I was pleased to find the article on tracheostomy care.
Religiosity and Therapeutic Alliance Among Youth Who Commit Sexual Crimes

Delinquency research argues that youth religion and spirituality are associated with desistence. The therapeutic alliance has been shown to be partially responsible for the influence of religiosity in therapeutic services. Asceticism within religious doctrine coupled with Social Bonding Theory, suggests perhaps existential and secular bonds may be a desistence mechanism or a mitigating factor against crimes like sexual abuse that violate religious or spiritual norms. Nevertheless, research has yet to integrate these concepts and test them among a sample of youth who commit sexual crimes. The present study proposes three hypotheses that use Ascetical and Social Bonding Theory as guiding theoretical frameworks to test the association between religiosity and criminal profiles and the associations between therapeutic alliance and self-reported religious importance. The cross-sectional study draws from original data collected from 332 incarcerated youth adjudicated for a sexual crime. Using validated and researcher-composed instruments and including relevant covariates, we used spearman’s rho correlations and multiple linear regression to test the relationships between criminal profiles, therapeutic alliance, and religiosity. The results indicated that the reported importance of religion prior to arrest is inversely associated with non-sexual criminality, but is not related to severity of sexual offense. Further, there were significant increases in pre-arrest and post-arrest religious importance. The therapeutic alliance predicted post-arrest religious importance. Implications for research and clinical practice are discussed. This study showcases the relationships between religious importance and general delinquent offending and how the therapeutic alliance is associated with religious importance. The findings align with tenants of Social Bonding Theory. These findings have implications for advancing research on religiosity and improving practice approaches for youth with sexual behavior problems.
Identifying hotspots in five year survival electronic health records of older adults

Understanding the prognosis of older adults is a big challenge in healthcare research, especially since very little is known about how different comorbidities interact and influence the prognosis. Recently, a electronic healthcare records dataset of 24 patient attributes from Northwestern Memorial Hospital was used to develop predictive models for five year survival outcome. In this study we analyze the same data for discovering hotspots with respect to five year survival using association rule mining techniques. The goal here is to identify characteristics of patient segments where the five year survival fraction is significantly lower/higher than the survival fraction across the entire dataset. A two-stage post-processing procedure was used to identify non-redundant rules. The resulting rules conform with existing biomedical knowledge and provide interesting insights into prognosis of older adults. Incorporating such information into clinical decision making could advance person-centered healthcare by encouraging optimal use of healthcare services to those patients most likely to benefit.
Close only counts in alcohol and violence: Controlling violence near late-night alcohol establishments using a routine activities approach

Abstract Purpose Assess whether 5 a.m. bars and nightclubs in Little Rock, AR were in fact serving to attract or generate violence in and around their premises and what impacts a new ordinance, requiring increased guardianship, served its intended purpose to reduce the incidence of violence. Methods Using violent crime data from the Little Rock Police, a series of Risk Terrain Models were utilized to examine whether the influence that proximity to a risk factor (5 a.m. alcohol establishments) has on violent crime changes after the new ordinance is established. Results Support for the ordinance was found for yearlong risk assessment, in that requiring 5 am alcohol establishments in Little Rock to employ a minimum of two law enforcement officers in and around the establishment acted as effective strategies to alter the guardianship and reduced the relative risk of violent crime in close proximity to these establishments. Conclusion The establishments were serving to attract/generate violent crime in and around their vicinity; however, support was found for the effectiveness risk reduction through increasing levels of guardianship and thus, reducing relative risk for violent crime. Furthermore, depending on the temporal aggregation, results varied on the potential riskiness associated with the 5 a.m. alcohol establishments.
Preliminary evidence for the efficacy of the Canine Surrogacy Approach in the Great Lakes

Abstract Isotopic analyses of human remains have been used to gain insights into aspects of subsistence and provide insights into mechanisms behind changes in material culture. Midwest archaeologists have used them to track major shifts such as the introduction of maize and associated changes in social organization. However, these destructive tests can create ethical and legal issues concerning the treatment of human remains. The Canine Surrogacy Approach (CSA) is the use of domestic dog remains as a proxy for human remains. Dog isotope values generally mirror their human companions', thereby circumventing the need to destroy human remains without sacrificing scientific research. This paper addresses the efficacy of CSA in the western Great Lakes.
In nonvalvular AF, DOAC-related risk for GI bleeding was lower with apixaban than dabigatran or rivaroxaban

Source Citation Abraham NS, Noseworthy PA, Yao X, Sangaralingham LR, Shah ND. Gastrointestinal safety of direct oral anticoagulants: a large population-based study. Gastroenterology. 2017;152:1014-...
Observations of grain boundary chemistry variations in a boron carbide processed with oxide additives

Abstract Analytical electron microscopy was used to examine the grain boundary chemistry in boron carbide containing Al-O-rich phases at triple junctions. In this study, SiO2, Al2O3, and B2O3 additives were used to synthesize an aluminoborosilicate glass on the grain boundaries with the long-term goal to enhance fracture resistance. Nanolayer films were not observed using high-angle annular dark field imaging; however, energy-dispersive spectroscopy quantification revealed grain boundaries with varying excess of Si and Al. Overall, it was concluded variations in grain boundary chemistry depend upon the intrinsic grain boundary character and spatial heterogeneity of the oxide additives.
Alumina waveguides for full-spectrum integrated photonics

We demonstrate fully confined waveguides in the ultraviolet spectrum, and present amorphous aluminum oxide as a viable waveguide platform for broad-spectrum integrated photonics with transmission from the infrared to the ultraviolet. Fabrication of aluminum oxide photonic structures and experimental results are discussed.
OBSERVATION OF SUB-DOPPLER LASER INDUCED NUCLEAR ORIENTATION OF 85mRb

Publisher Summary This chapter presents the observation of sub-Doppler resolved gamma anisotropy produced by laser-induced nuclear orientation (LINO). Sub-doppler LINO is uniquely suited for resolving closely spaced hyperfine structure (hf) of short-lived isomers. Sub-Doppler LINO allows more precise measurements of hf splittings to be made. This leads to more accurate measurements of nuclear magnetic dipole and electric quadrupole moments and isomer shifts. LINO uses laser optical pumping to produce electronic alignment. This is transferred to the excited nucleus by the hyperfine interaction. When the oriented nuclei decay, anisotropy is observed in the spatial distribution of the emitted gamma rays. The hf of the isomer is determined by monitoring the anisotropy as a function of laser detuning. Many applications of LINO require the use of a buffer gas. The main effect of the buffer gas is to induce velocity-changing collisions between the isomers and the buffer gas atoms.
Proteasome storage granules protect proteasomes from autophagic degradation upon carbon starvation.

Proteins perform many jobs within an organism, including providing structure and support, and protecting against infection. The levels of the many proteins in a cell need to be carefully controlled so that the correct amounts are present at the right place and time to perform these tasks. This control can be achieved by balancing the production of new proteins with the break down (or degradation) of proteins that are no longer required or become dysfunctional. Most cells have two pathways for degrading proteins. One pathway breaks down individual proteins specifically marked for elimination; this causes them to be recognized by a structure called the proteasome, which chops proteins into smaller pieces. Larger protein assemblies – including the proteasome itself – are to big for the proteasome and thus need to be degraded by another pathway called autophagy. This process engulfs and delivers parts of a cell to a membrane-bound compartment called the vacuole, which ‘digests’ and recycles these larger constituents. Proteasomes are degraded by autophagy when they are not working correctly and when nitrogen (a crucial nutrient) is in short supply. However, proteasomes are not degraded when cells lack carbon, even though this starvation is known to activate autophagy in the same way that an absence of nitrogen does. So how do proteasomes escape degradation when cells are starved for carbon? Marshall and Vierstra now show that upon carbon starvation, proteasomes rapidly exit the cell nucleus and cluster together in the main part of the cell (termed the cytosol). These clusters are known as proteasome storage granules (PSGs). In fungi and plants, mutations or conditions inside the cell that make it difficult for PSGs to assemble cause proteasomes to instead be broken down in the vacuole when carbon availability is low. Clustering into PSGs therefore protects proteasomes from autophagy. This clustering appears advantageous to cells; yeast cells that could form PSGs were better able to start growing again when their nutrient supply improved. Protein clustering (also known as aggregation) is an important strategy that cells use to survive stressful conditions. However, it can also be harmful when proteins aggregate inappropriately, such as occurs in Alzheimer’s disease. Researchers may be able to use PSG assembly as a convenient model to study the causes and consequences of protein aggregation; this knowledge could ultimately be applied to improve human health and crop productivity.
Palladium nanoparticles: Chemoselective control for reductive Heck with aryl triflates and 2,3-dihydrofuran

Abstract The reductive-Heck reaction offers a unique entry to formal Csp2-Csp3 cross-coupling reactions that proceed in the absence of a main group organometallic coupling partner. Consequently, further development of new variants would be transformative. Unfortunately, controlling the relative rates of the organopalladium intermediates has proven difficult with homogenous, single-site Pd catalysts. This work describes a selective reductive Heck reaction catalyzed by Pd-nanoparticles. The reaction works well with electron-deficient aryl triflates at room temperature in the absence of ligands. This work addresses some of the challenges found in the reductive-Heck literature.
m.Site: efficient content adaptation for mobile devices

Building a mobile user interface can be a time consuming process for web site administrators. We present a novel approach for adapting existing websites to the mobile paradigm. In contrast to existing technologies, our approach aims to provide a trio of functionality, ease of use, and scalability for large web communities. A site administrator visually selects objects within a web page, and assigns one or more attributes to page objects from a rich collection of pre-defined page modifications. Our proposed system then generates code for a multi-session, php-based proxy server to provide dynamic mobile content adaptations based on the attributes selected. The modifications encapsulate complex page interactions and provide a simplified interface to mobile users. The proxy server is augmented with a highly efficient and standards-compliant browser residing on the server to interpose on behalf of a resource-constrained mobile client. Adaptations such as pre-rendering of content can be cached and shared across users to amortize load. We build a prototype and evaluate its efficacy on a complex web application driving a busy online community with nearly 66,000 members.
A computational study of symmetry and well-posedness of structural topology optimization

We are concerned with the computational topological optimization of elastic structures, in particular minimization of compliance subject to a constraint on the mass. Through computational experiments, it is discovered that even very simple optimization problems can exhibit complex behavior such as critical points and bifurcation. In the vicinity of critical points, structural topology optimization problems are not well-posed since infinitesimally small perturbations lead to distinct topologies.
TYPE AND AMOUNT OF HCBS USED BY PENNSYLVANIA AGING WAIVER CONSUMERS

This study identifies the type and amount of HCBS services used by Pennsylvania Medicaid aged waiver. We examined the distribution of each major service type used by aged Medicaid Waiver recipients between 2013 - 2015. We examined the use of personal attendant services (PAS), home delivered meals, adult day care, and environmental modifications and we distinguished between PAS provided through an agency versus the consumer directed model. People who live in rural areas are more likely to use consumer directed PAS compared to urban areas. Non-white HCBS beneficiaries were more likely to use agency-based PAS. People with relatively low amounts of PAS (under 4 hours per person per day) were more likely to also use home delivered meals and adult day services when compared to people who received a higher number of hours per person day. These findings identify important patterns to monitor as the CHC program is implemented.
Benefits of Using VCO-OTAs to Construct TIAs in Wideband Current-Mode Receivers Over Inverter-Based OTAs

A filterless blocker-tolerant current-mode receiver using a voltage-controlled oscillator-based operational transconductance amplifiers (VCO-OTAs) for the baseband transimpedance amplifiers (BB TIAs) is presented as an alternative to inverter-based OTAs (inv-OTAs). Three key advantages of VCO-OTAs over inv-OTAs are a high-dc gain, a higher bandwidth for a given dc gain, and independent control of noise and the unity-gain bandwidth. These advantages are used to demonstrate power reduction in the BB TIAs, the low-noise transconductance amplifier, and the passive mixer LO drivers in the receiver. A design methodology for the choice of the VCO-OTA parameters in the context of a receiver design is illustrated with an example of a 20-MHz RF-channel bandwidth receiver operating at 2 GHz. Receiver simulation results indicate an improvement of up to 12 dB in blocker 1-dB compression point (B1dB) for slightly higher power consumption or up to $2.6\times $ power reduction of the TIA resulting in up to $2\times $ power reduction of the receiver for similar B1dB performance.
Dual ion irradiation of commercial and advanced alloys: Evaluating microstructural resistance for high dose core internals

Abstract Ten alloys including austenitic stainless steels 316L and 310; Ni-base alloys X750, 718, 725, 690, 625, and C22; and advanced ferritic alloys T92 (optimized) and 14YWT were irradiated in dual ion mode at 400 °C with ∼5 MeV self-ions to a damage level of 150 dpa and with degraded 2 MeV helium to a concentration of ∼13 appm He/dpa. Irradiation-induced dislocation loops and nanoscale cavities were observed across the alloys, but with only modest swelling. Pre-existing γ ′ and γ ″ precipitates were dissolved or chemically disordered by irradiation, while irradiation-induced phases (e.g., Ni2Cr, G-phase) did not form. In terms of microstructural change, the ferritic alloys, as a class, showed the best radiation resistance while the austenitic stainless steels showed the worst. Radiation resistance among the Ni-base alloys varied significantly, with precipitation-hardened alloys performing worse and dislocation loop content increasing with iron content. These findings were in broad agreement, qualitatively and quantitatively, with past dual beam and in-reactor irradiations of structural materials, demonstrating the utility of dual ion irradiations to capture key evolution quickly and accurately.
Evaluating the efficacy of the single-incision uphold system for pelvic organ prolapse repair.

Abstract Objective The aim of this study was to assess the efficacy and clinical outcomes of pelvic floor reconstruction with transvaginal mesh of the Uphold™ Vaginal Support System (Boston Scientific Corporation). Materials and methods This retrospective study reviewed the medical records of patients with pelvic organ prolapse stage 3 or 4 who underwent pelvic reconstructive surgery with transvaginal mesh of the Uphold™ Vaginal Support System from January 2015 to March 2017. Patients who were treated with laparoscopic sacrocolpopexy, transvaginal sacrospinous ligament suspension or other mesh kits were excluded. Assessments included pre- and postoperative Pelvic Organ Prolapse Quantification (POP-Q) stage, Urogenital Distress Inventory-6 (UDI-6), Incontinence Impact Questionnaire-7 (IIQ-7), urodynamic parameters, peri- and postoperative complications and symptoms. Results Of the 111 enrolled women, the anatomical success rate was 97.3% after a median 18.4 months of follow-up. POP-Q parameters, UDI-6 and IIQ-7 scores, maximum urine flow rate, and post-void residual urine all significantly improved after surgery. Complications included one case (0.9%) of infected hematoma, two cases (1.8%) of mesh exposure, three cases (2.7%) of recurrent prolapse, and 12 cases (10.8%) of transient urine retention. No bladder or bowel injuries occurred during surgery. Conclusions Pelvic reconstructive surgery with transvaginal mesh of the Uphold™ System yielded satisfactory anatomical and urinary functional outcomes in a median 18.4 months of follow-up. IRB identifier IRB: 201700645B0
Antidepressants are modifiers of lipid bilayer properties.

The two major classes of antidepressants, tricyclic antidepressants (TCAs) and selective serotonin reuptake inhibitors (SSRIs), inhibit neurotransmitter reuptake at synapses. They also have off-target effects on proteins other than neurotransmitter transporters, which may contribute to both desired changes in brain function and the development of side effects. Many proteins modulated by antidepressants are bilayer spanning and coupled to the bilayer through hydrophobic interactions such that the conformational changes underlying their function will perturb the surrounding lipid bilayer, with an energetic cost (Δ G def ) that varies with changes in bilayer properties. Here, we test whether changes in Δ G def caused by amphiphilic antidepressants partitioning into the bilayer are sufficient to alter membrane protein function. Using gramicidin A (gA) channels to probe whether TCAs and SSRIs alter the bilayer contribution to the free energy difference for the gramicidin monomer⇔dimer equilibrium (representing a well-defined conformational transition), we find that antidepressants alter gA channel activity with varying potency and no stereospecificity but with different effects on bilayer elasticity and intrinsic curvature. Measuring the antidepressant partition coefficients using isothermal titration calorimetry (ITC) or cLogP shows that the bilayer-modifying potency is predicted quite well by the ITC-determined partition coefficients, and channel activity is doubled at an antidepressant/lipid mole ratio of 0.02–0.07. These results suggest a mechanism by which antidepressants could alter the function of diverse membrane proteins by partitioning into cell membranes and thereby altering the bilayer contribution to the energetics of membrane protein conformational changes.
A 40-Year-Old Male Presenting with Hereditary Multiple Exostosis: Management and Considerations.

Hereditary multiple exostosis is a rare condition in which numerous benign osteochondromas form throughout the body, typically in areas of high bone turnover such as the metaphyseal plates of long bones. While many of these lesions remain clinically asymptomatic, other growth locations can lead to excruciating pain, limit a joint’s range of motion, and compromise neurovascular structures. These patients undergo multiple surgeries throughout their lifetime in order to remove symptomatic osteochondromas. Due to deformities and changes in bone structure, these patients also suffer from significant arthritis which may also require surgery. It is important that a skilled orthopedic surgeon follow these patients in order to help them make informed decisions and limit the number of surgeries within their lifetime. The purpose of this case report is to discuss one instance in which a patient’s significant arthritis was operatively managed in the setting of hereditary multiple exostosis.
Thermally-Induced morphological evolution of spherical silica nanoparticles using in-operando X-ray scattering measurements

Abstract The assembly and morphology of pores determine thermodynamic, flow and reactive properties of confined fluids. However, there is a limited understanding of how pore architectures dynamically develop in engineered and natural materials. To develop a calibrated understanding of fluid properties in confinement, the synthesis of architected materials has been proposed. The design of geo-architected materials has to be informed by the dynamic evolution of the morphology in response to thermal or chemical events. In this study, we probe thermally induced morphological evolution of spherical silica nanoparticles 220 ± 30 nm in diameter using in-operando Ultra-Small and Small Angle X-Ray Scattering measurements. The calcination experiments demonstrated that at temperatures up to 600 °C the pore radii remained in the range of 2.15 nm–2.35 nm and the particle diameters in the range of 220 ± 30 nm. Sintering these calcined silica nanoparticles to temperatures up to 1050 °C reduced the pore size from 2.2 ± 0.1 nm to ∼1.8–0.2 nm. These changes corresponded to the formation of siloxane (Si-O-Si) bridges resulting from dehydroxylation. The characteristic pore radius of sintered particles was also confirmed by N2 adsorption measurements. These studies represent the use of non-invasive dynamic characterization methods such as X-ray scattering to elucidate thermally induced morphological evolution in architected siliceous materials.
Angiotensin III induces p38 Mitogen-activated protein kinase leading to proliferation of vascular smooth muscle cells

Mitogen-activated protein kinases (MAPKs) are essential molecular transducers of extracellular stimuli into intracellular responses. MAPKs are crucial in mediating actions of the renin–angiotensin–aldosterone system (RAAS), in particular, functions mediated by Angiotensin (Ang) II, the main biological peptide produced by this system. We have shown that another biologically active heptapeptide Ang III also induces MAPKs in the central nervous system. The ability of Ang III to induce MAPKs in the periphery is unknown and was the focus of this study. We determined whether Ang III induced p38 MAPK in vascular smooth cells (VSMCs) isolated from Wistar and spontaneously hypertensive rats (SHRs) and compared these actions to those of Ang II. Further, the role of this MAPK in Ang III-mediated VSMC proliferation was also determined. Both Ang peptides similarly induced p38 MAPK phosphorylation in VSMCs of Wistar VSMCs in a concentration- and time-dependent manner. SHR VSMCs were less sensitive to Ang III, which caused less of an effect on p38 MAPK phosphorylation in these cells. The Ang III effect was specific and occurred by activation of the Ang type 1 (AT1) receptor. The p38 MAPK pathway was also involved in Ang III-induced VSMC growth, as measured by DNA synthesis. These findings suggest that the p38 MAPK signaling pathway is an important cascade in regulating the actions of Ang III in VSMCs. Most importantly, dysregulation of Ang III actions in these cells are apparent and may contribute to pathological conditions associated with dysfunctions in VSMCS.
Surface roughness and densification correlation for direct metal laser sintering

The increasing use of metal additive manufacturing (AM) technologies, such as direct metal laser sintering (DMLS), requires an in-depth understanding of how the optimum DMLS process parameters can be determined to achieve the target properties, such as reduced defect densities and/or desired surface characteristics. To this end, it is important to develop simple strategies that assess part quality and are fast and cost-effective. In this study, the in-plane surface roughness of components fabricated with AM is correlated with the DMLS process parameters and fractional density, enabling rapid and accurate indirect determination of the fractional density of AM components through surface roughness measurements. To this end, two sets of DMLS process parameters and a geometrical parameter are utilized to fabricate more than 150 rectangular cubic samples with varying parameters. All the samples are fabricated using Ti-6Al-4 V powder, which is a frequently used metal alloy for DMLS. Second, two line roughness parameters are defined and measured for all the samples, and their correlations with the DMLS and geometrical parameters are reported. Third, the fractional densities of all the samples are measured and their correlations with the DMLS process parameters are demonstrated. Lastly, a thorough analysis of the observed correlations between the line roughness parameters and fractional density are discussed.
Data-Driven, Automated Healthcare: Its Promise, Challenges, and Regulatory Playing Field

The future of data-driven, automated healthcare holds both a lot of promise and uncertainty. It is promising because of its ability to make precision medicine and practice-based medicine truly a reality. It is uncertain because the regulatory playing field for this emerging industry has yet to pan out. To date, the US Food and Drug Administration (FDA) still considers health information technology (HIT) software as a medical device. So far the FDA does not subject HIT software to as much regulatory scrutiny as traditional medical devices undergo, but has been criticized for using an outdated regulatory framework to govern modern health technologies. As such technologies become increasingly more prevalent and its capabilities much more salient, potentially affecting the lives of hundreds of millions, will the FDA be able to 1) handle the onslaught of new companies and regulatory burden 2) mitigate risks to public health while promoting innovation? This paper will first discuss the potential of data-driven, automated healthcare and examples of what it currently is and may become (Section I), followed by an explanation of current regulations and why it has its limitations (Section II), exploration of newly proposed legislations (Section III), and finally recommendations to implementing a smarter regulatory environment for AI-driven healthcare in the future (Section IV).
Evaluation of Fetal Cardiac Size and Shape: A New Screening Tool to Identify Fetuses at Risk for Tetralogy of Fallot.

OBJECTIVE Prenatal detection rates for tetralogy of Fallot (TOF) vary between 23 and 85.7%, in part because of the absence of significant structural abnormalities of the 4-chamber view (4CV), as well as the relative difficulty in detection of abnormalities during the screening examination of the outflow tracts. The purpose of this study was to evaluate whether the 4CV and ventricles in fetuses with TOF may be characterized by abnormalities of size and shape of these structures. METHODS This study retrospectively evaluated 44 fetuses with the postnatal diagnosis of TOF. Measurements were made from the 4CV (end-diastolic length, width, area, global sphericity index, and cardiac axis) and the right (RV) and left (LV) ventricles (area, length, 24-segment transverse widths, sphericity index, and RV/LV ratios). Logistic regression analysis was performed to identify variables that might separate fetuses with TOF from normal controls. RESULTS The mean gestational age at the time of the last examination prior to delivery was 28 weeks 5 days (SD 4 weeks, 4 days). The mean z-scores were significantly lower in fetuses with TOF for the 4CV and RV and LV measurements of size and shape. Logistic regression analysis identified simple linear measurements of the 4CV, RV, and LV that had a sensitivity of 90.9 and specificity of 98.5% that outperformed the 4CV cardiac axis (sensitivity of 22.7%) as a screening tool for TOF. CONCLUSIONS Measurements of the 4CV, RV, and LV can be used as an adjunct to the outflow tract screening examination to identify fetuses with TOF.
A woman with gingival enlargement

A 65-year-old female complained of diffuse and rapidly progressive gingival enlargement. Gingival overgrowth can be caused by medication, infections or systemic diseases. In case of generalized, quickly progressive gingival enlargement, acute myeloid leukemia should be considered. Blood results showed an acute myelomonocytic leukemia. Treating the leukemia resolved the symptoms.