cssi/SciSciGPT-SciSciNet huggingface dataset:
Clinicopathologic conference; unexpected death in an adult with congenital heart disease.

lobes, orthopnea, edema of the ankles or hemoptysis. During his entire lifetime the patient seemed to be peculiarly susceptible to infections of the upper respir­ atory tract, and these usually did not respond well to treatment. The episode leading to this last hospitalization was unusually persistent with more fever (up to 102 F.), and for the first time he had pain in the left anterior region of the chest. Physical examination. The patient was thin and underdeveloped, weighing only 148 pounds, considerably less than the average for a man 6 feet 2 inches in height. The lips, ear lobes and fingers were slightly cyanotic, and a minimal degree of clubbing was noted in the fingers. The temperature was 101 F., the pulse rate 90 per minute and regular, and the blood pressure 110/65. The chest was asymmetric, owing to prominence of the left precordia, and percussion revealed dullness posteriorly and laterally on the left side of the thorax. Voice and breath sounds were diminished in the same region, but no rales were heard. The area of cardiac dullness extended to the left anterior axillary line, and the point of maximum impulse was 11 cm. to the left of the midsternal line in the fifth costal interspace. A single, loud, systolic murmur was heard over the entire precordia, estimated as grade IV on the basis of 6 grades. The region of its maximal intensity was just to the left of the sternum in the third costal interspace, where an associated systolic thrill was palpated. In addition, a grade II diastolic murmur was heard only in this area. The pulmonary second sound was split and greatly accentuated. The liver and spleen were not palpable, peripheral pulsations were normal, and there was no edema of the
Japygidae of North America, 5. Species of Evalljapyx with 30 ± 1 Segments in the Antenna (Order Diplura)

Of the six known species falling in this group, E . anombris , E . ombris , E . newelli , and E . adonis are described from California, E . macswaini from Nevada, and E. sonaranus Silvestri is redescribed from Arizona material. A key to these species is given.
Isomerization studies: III. decarbonylation of oleoyl chloride preparation of C19 dicarboxylic acids

Mixtures of siomeric C17 diene hydrocarbons were obtained when oleoyl chloride was decarbonylated in the presence of a transition metal catalyst. The choice of catalyst determined the composition of diene mixture produced. Diene mixtures were characterized as a mixture of conjugated and 1,4- dienes, or as a mixture of isolated double bond dienes. Carboxylation of the conjugated C17 diene by hydroformylationoxidation procedure gave a C18 monocarboxylic acid as the major product, whereas with nonconjugated C17 diene, the major product was a C19 dicarboxylic acid. Application of the Koch carboxylation procedure to C17 diene mixtures gave a C19 dicarboxylic acid mixture as the major product. This latter acid mixture was structurally different from diacids obtained from the hydroformylation-oxidation procedure.
Electrophysiological characterization and computational models of HVC neurons in the zebra finch.

The nucleus HVC (proper name) within the avian analog of mammal premotor cortex produces stereotyped instructions through the motor pathway leading to precise, learned vocalization by songbirds. El...
Microstructures of Friction Surfaced Coatings – a TEM Study

Abstract The microstructures of dissimilar metal welds between 9Cr-1Mo (Modified) (P91) and austenitic stainless steel (AISI 304) with Ni-based alloy interlayers (Inconel 625, Inconel 600 and Inconel 800H) are reported. These interlayers were deposited by the friction surfacing method one over the other on P91 alloy, which was finally friction welded to AISI 304. In this paper, the results of microstructural evolution in the friction surfaced coated interlayers (Inconel 625, 600, 800H) are reported. For comparative purposes, the microstructures of consumable rods (Inconel 625, 600, 800H) and dissimilar metal base metals (P91 and AISI 304) were also reported. Friction surfaced coatings exhibited dynamic recrystallization. In friction surfaced coatings, the carbide particles were found to be finer and distributed uniformly throughout the matrix, compared to their rod counterparts.
The Predictive Effect of High Sensitivity C-reactive Protein in Patients With Ventricular Arrhythmia Occurrence

Objective: To explore the predictive effect of high sensitivity C-reactive protein(hs-CRP) in patients with ventricular arrhythmia occurrence and implanted cardiovascular defibrillation(ICD) or cardiac resynchronization therapydefibrillator(CRT-D).Methods: A total of 122 consecutive patients with ICD or CRT-D implantation were retrospectively summarized, the patients had no ventricular arrhythmia occurrence within 1 month of the enrollment. According to the post operative program-controlled study, the patients were divided into 2 groups as Occurrence group, n =48 and Not occurrence group, n=74. The hs-CRP level was examined in all patients before the operation, the relationship for hs-CRP level and ventricular arrhythmia occurrence was compared between 2 groups.Results: There were 189 times of ventricular arrhythmia found in Occurrence group, the hs-CRP level was higher than that in Not occurrence group as(6.97±3.57) mg/L vs(2.13±1.86) mg/L, P0.001. The patients with histories of syncope and atrial fibrillation before the operation had the higher ventricular arrhythmia rate than those without such histories. The family history and other inflammatory index like sedimentation rate and white blood cell count were not related to ventricular arrhythmia occurrence.Conclusion: In patients without arrhythmia before operation, increased hs-CRP level was related to post operativeventricular arrhythmia after ICD or CRT-D implantation, while hs-CRP was not the only predictor for ventricular arrhythmia occurrence.
Untangling the Mystery of Teaching Business Organizations

Drawing on over 20 years of experience, this article outlines my pedagogy for teaching Business Organizations. To help students make sense out of what initially appears to be a disorganized mess, I organize the course to loosely follow the historical evolution of business organizations. I start with the general partnership, the oldest form. After explaining how and why corporate general laws evolved in the late 19th and early 20th centuries, I transition to corporate law as it applies to big business. I start with shareholders' rights and then move to the fiduciary duties owed by the board of directors. In this section I refer to specific parts of James Stewart's nonfiction book, DisneyWar, to add more life to the material. I transition to closely held corporations, which emerged by the middle of the 20th century as an important avenue for small businesses to enjoy the corporate veil and then detail the legal problems the shareholders encounter. I end the course with the rise of limited liability companies (LLCs) the fastest growing new business organization, and to a lesser extend limited liability partnerships (LLPs). I work into the historical explanation of the LLC's rise (with a brief sketch of the significant role business tax played) an overview of the limited partnership, which is now less frequently used. I emphasize to the students that LLCs are a hybrid between corporations and partnerships, with great variation among the states, that offer the corporate veil and almost always favored partnership taxation. I also point out that publicly traded Delaware LLCs with weaker fiduciary duty protections than publicly traded Delaware corporations are starting to emerge.
SPMario: Scale up MapReduce with I/O-Oriented Scheduling for the GPU

The popularity of GPUs in general purpose computation has prompted efforts to scale up MapReduce systems with GPUs, but lack of efficient I/O handling results in underutilization of shared system resources in existing systems. This paper presents SPMario, a scale-up GPU MapReduce framework to speed up job execution and boost utilization of system resources with the new I/O Oriented Scheduling. The evaluation on a set of representative benchmarks against a highly-optimized baseline system shows that for the single job cases, SPMario can speedup job execution by up to 2.28×, and boost GPU utilization by 2.12× and 2.51× for I/O utilization. When scheduling two jobs together, I/O Oriented Scheduling outperforms round-robin scheduling by up to 13.54% in total execution time, and by up to 12.27% and 14.92% in GPU and I/O utilization, respectively.
Investors and the Geography of the Subprime Housing Crisis

In this article we investigate the connections between home purchases by individual investors and urban space by exploring the spatial dimension of investor lending in Chicago and Cook County, Illi...
Opposing roles of tyrosine kinase receptors Mer and Axl determine clinical outcome in a mouse model of nephritis

Systemic lupus erythematosus (SLE) is an autoimmune disorder with unknown etiology. Lupus nephritis remains one of the most severe manifestations of SLE, with considerable morbidity and mortality. There remains a major void in the successful management of lupus nephritis. TAM (Tyro-3, Axl and Mer) receptor tyrosine kinases play an important role in the maintenance of immune homeostasis. Mer is constitutively highly expressed on glomerular endothelial cells; Axl expression is inducible in kidney under inflammatory conditions. To investigate the functions of Axl and Mer in lupus nephritis, we induced glomerulonephritis in WT, Axl-KO, Mer-KO, and A/M-KO (Axl/Mer-double knockout) mice by injection of nephrotoxic serum (NTS). Mer-KO mice developed severe glomerulonephritis, with significantly decreased survival rate and increased blood urea nitrogen (BUN) levels as compared to WT mice given the same treatment. Two weeks after injection, necrotic cell death was evident in the glomeruli of Mer-KO mice. However, Axl-KO presented with significantly increased survival rate and reduced BUN as compared to the WT, Mer-KO and A/M-KO mice injected with the same serum. Interestingly, the A/M-KO mice developed kidney inflammation comparable to WT mice. Western blot analysis revealed significantly increased Stat3 phosphorylation and caspase-1 activation in the kidney of Mer-KO mice after NTS injection. In contrast, Axl deficient NTS-injected mice developed decreased Akt phosphorylation and Bcl-xl upregulation. The reciprocal activation of Axl and Mer receptor tyrosine kinases may have a major impact on renal inflammation. Results from these studies may lead to novel therapeutic drug development targeted to lupus nephritis.
Effects of Structural Attributes and Phase Ratio on Moisture Diffusion in Crystallized Lipids

The objective of this investigation was to study the effect of crystallization conditions and constituent phase ratio on moisture diffusion in lipids. Lipid samples were prepared by fast (13 °C/min) or slow (0.7 °C/min) cooling of binary trilaurin-triolein blends at 200 s–1 shear rate from 60 to 38 °C. Faster cooling at constant shear rate decreased crystal sizes and increased fractal dimensions (Dbox). Effective moisture diffusivities (Deff) were calculated as a sum of vapor (Dv,eff) and liquid phase (Dl,eff) diffusivities by using measured structural data in a diffusion model. Although no correlation was observed between overall Deff and crystallization conditions, the Deff values increased with triolein content from 5.8 to 7.5 × 10–12 (no triolein) to 1.2 to 1.3 × 10–12 m2/s (40% triolein). Results showed that, due to the large magnitude of water vapor diffusivity in air, the impact of structural variations caused by varying cooling rates on overall Deff was masked. However, there was a strong correlat...
Task Representation and Constraint Analysis for Hybrid Position/Force Controller Design

Abstract The problem of controlling a manipulator constrained by contact with the environment is described, and a new method for the design of a hybrid position/force controller is developed. A representation of the instantaneous kinematics of a task is derived, and the constraint on a manipulator due to contact uith the environment is analysed. The task is modeled as a set of essential vectors in the directions critical to the performance of the task. The constraint on a manipulator is modelled as a set of admissiblt joint motion vectors, and a set of admissible joint force vectors. A new method for designing a hybrid position/force controller is then developed to control the joints of a manipulator so that the desired task is performed at the end effector using only motions and forces allowed by the constraint. The method can be applied to all type of manipulators constrained due to contact with the environment, including manipulators constrained due to more than one robot grasping a workpiece and manipulators constrained due to the bracing of the arm against, against a work surface. The method is illustrated by a simple three degree of freedom example
Cux1 promotes cell proliferation and polycystic kidney disease progression in an ADPKD mouse model.

Autosomal dominant polycystic kidney disease (ADPKD) is one of the most common monogenic hereditary disorders in humans characterized by fluid-filled cysts, primarily in the kidneys. Cux1, a cell c...
PROCEDURAL JUSTICE THEORY AND EVALUATIONS OF THE LAWMAKING PROCESS

Americans believe that Congress' most important duties are passing laws and dealing with the nation's problems. A majority, however, disapprove of the way that these functions are carried out. Drawing on procedural justice literature, this article examines the role that process perceptions play relative to preferred outcome in people's legitimacy assessments. In particular, a controlled experiment tests the argument that the weight assigned to procedural justice considerations relative to policy considerations is in part a function of the information environment and the types of issues under deliberation.
Numerical Study of Turbulent Channel Flow over Surfaces with Variable Spanwise Heterogeneities: Topographically-driven Secondary Flows Affect Outer-layer Similarity of Turbulent Length Scales

Wall-bounded turbulent flows over surfaces with spanwise heterogeneous surface roughness – that is, spanwise-adjacent patches of relatively high and low roughness – exhibit mean flow phenomena entirely different to what would otherwise exist in the absence of spanwise heterogeneity. In the outer layer, mean counter-rotating rolls occupy the depth of the flow, and are positioned such that “upwelling” and “downwelling” occurs above the low and high roughness, respectively. It has been comprehensively shown that these secondary flows are Prandtl’s secondary flow of the second kind (Anderson et al., J. Fluid Mech. 768, 316–347 2015). This behaviour indicates that spanwise spacing, s y , between adjacent patches of high and low roughness is, itself, a problem parameter; in this study, we have systematically assessed how s y affects turbulence structure in high Reynolds number channel flows via two-point correlations. “High roughness” is imposed with streamwise-aligned pyramid elements with height, h, selected to be ≈ 5% of the channel half height, H. For $s_{y}/H \gtrsim 1$ , we find that the aforementioned domain-scale mean circulations exist and the surface may be regarded as a topography. For s y /H ≲ 0.2, turbulence statistics show characteristics very similar to a homogeneous roughness and thus the surface may be regarded as a roughness. For 0.2 ≲ s y /H ≲ 2, the spatial extent of the counter-rotating rolls is controlled by proximity to adjacent rows, and we define such surfaces as being intermediate. We refer to such surfaces as intermediate state.
Epidemiology of Hospitalized Heart Failure: Differences and Similarities Between Patients with Reduced versus Preserved Ejection Fraction

Abstract Annually, more than 1 million patients are hospitalized for heart failure (HF), translating to high healthcare utilization and cost burden. Among patients with hospitalized HF (HHF), approximately 50% have HF with preserved ejection fraction (HFpEF) and 50% have HF with reduced ejection fraction (HFrEF), with the proportion of patients with HFpEF increasing with time. This article defines the epidemiologic landscape of patients with HHF, comparing and contrasting those with HFpEF and HFrEF, and identifies key areas that require further investigation. More complete characterization of these populations may be the first step to developing effective therapies.
Frameworks of Police Leadership: Evolution of Change

The United States is comprised of approximately 18,000 law enforcement agencies. According to the Justice Department’s Bureau of Justice Statistics roughly half of those agencies are comprised of ten or fewer members. Seventy-five percent of those have fewer than 25 officers patrolling in counties or towns where standards and practices are not consistent. Quality control is hindered by the small size of these agencies. There are no national standards in regard to all of these agencies in reference to management or leadership. When we moderate productivity, motivation, and scope of the job, what type of leaders do we rely on to make decisions? In police departments, officers often have freedom and discretion to do what they choose during day-to-day operations. Often they have limited supervision for most of their workday. The result is they are left to learn leadership from their peers and their own experiences. Police leadership is cultivated, not through formal training or education, but from attributes, skills, and informal development. Most depend on their life experiences, guidance from their superiors, and whatever culture exists within their individual agency. If agencies have a culture of high standards, then likely they have adopted the same standards for promoting and training their leadership. However, many agencies do not have even basic testing in place to determine a baseline competency level for its street-level supervisors. When you start at a low threshold this standard is likely to carry up to the higher levels of the agencies’ management. This is not a catch-all for all law enforcement agencies across the country. As there is no national standard, most states have created their own quality of professional standards and training requirements. With law enforcement agencies under such scrutiny today I explore the perceptions and frameworks in place that develop leadership within this culture.
Mycobacterium abscessus Complex Infections in Children: A Review.

Purpose of Review Infections in children with Mycobacterium abscessus complex represent a particular challenge for clinicians. Increasing incidence of these infections worldwide has necessitated focused attention to improve both diagnostic as well as treatment modalities. Published medical literature was reviewed, with emphasis on material published in the past 5 years.
Utilization pattern of other preventive services during the US Medicare annual wellness visit

Annual wellness visit (AWV) was introduced for Medicare patients in 2011 to help patients stay healthy. The object of this study is to assess whether AWV have an impact on the use of other preventive services in the eligible population. Medicare claims for the full sample of beneficiaries who were continuously enrolled in fee-for-service Medicare in 2013 and 2014 were analyzed. The association between AWV and three other preventive services (depression screening [DPS], influenza virus vaccine [IVV], and sexually transmitted infection screening [STI]) were assessed. In addition, the utilization pattern of these three preventative services at AWV visit by the calendar month when beneficiaries had an AWV service was also assessed. Of 28 million eligible Medicare beneficiaries, 16.0% had AWV in 2014. The patients who had AWV had a significantly higher percentage of three preventive services than those who had no AWV: 63.8% vs. 41.6% in IVV, 4.9% vs. 0.5% in DPS, and 2.3% vs. 1.8% in STI. The percentages of beneficiaries who received IVV during an AWV visit varied significantly by calendar month: from < 0.1% in June to 36.8% in October. AWV is associated with increased use of other preventive services. In addition, the association is significantly affected by type of other preventive services that may be highly related with seasonal factors.
Steepness for West Coast rockfishes: Results from a twelve-year experiment in iterative regional meta-analysis

Abstract Theoretical and applied research suggests that survival rates during early life stages will increase when spawning biomass is reduced in marine fishes (termed “recruitment compensation”). However, the magnitude of recruitment compensation is generally difficult to estimate for individual fish stocks, and its average value for marine fishes remains highly contested. Scientists and managers for Pacific rockfishes (Sebastes spp.) on the US West Coast have used a regional meta-analysis to estimate the likely distribution of the steepness parameter of the Beverton-Holt stock-recruit relationship using stock assessment models since 2007, and the method has been updated every two years as new assessments are conducted (i.e., five biennial updates). Here, we provide a short history of this approach, its methodological assumptions, changes in results over time, and ongoing efforts to validate its assumptions. While the regional meta-analysis has been successful in ensuring a consistent approach to treatment of steepness across assessments, the estimates of mean steepness have been unexpectedly variable as the meta-analysis has been updated. Specifically, we show that the estimated average value of steepness for West Coast rockfish increased markedly from 2007 (average: 0.75), before decreasing somewhat again in the 2017 update. We also show that this value has a strong impact on rockfish rebuilding plans, and showcase the example of canary and widow rockfishes, where the estimated rates of rebuilding are strongly influenced by the assumed value of steepness. We conclude by discussing the bias-variance tradeoff between using global and regional meta-analysis, as well as the likely implications of difficult-to-validate assumptions including: (1) no recruitment autocorrelation within each stock; (2) no correlations among stocks; and (3) no bias from individual stocks resulting from mis-specification of the stock assessment models used in the meta-analysis.
Safety of ferumoxytol in children undergoing cardiac MRI under general anaesthesia

BackgroundFerumoxytol, an “off-label” contrast agent, allows for better cardiac MRI quality as compared with gadolinium-based contrast agents. However, hypotension has been reported with the use of ferumoxytol for indications other than cardiac MRI. The purpose of our investigation was to evaluate the safety of ferumoxytol in children undergoing general anaesthesia for cardiac MRI.MethodsMedical records of children undergoing general anaesthesia for cardiac MRI were reviewed. Baseline demographic and medical characteristics, as well as imaging and anaesthetic duration and technique, were collected. The incidence of hypotension or other adverse events’, need for vasoactive support, or airway intervention throughout the anaesthetic, was recorded.ResultsA total of 95 patients were identified, 61 received ferumoxytol and 34 received gadolinium. There were no significant differences between groups with respect to age, weight, or baseline blood pressure. The incidence of low blood pressure – systolic or mean – after contrast administration did not differ between groups, and there was no difference in sustained hypotension or use of vasopressors between groups. One patient who received ferumoxytol had possible anaphylaxis. The image acquisition time (45 versus 68 min, p=0.002) and anaesthesia duration (100 versus 132 min, p=0.02) were shorter in the ferumoxytol group.ConclusionTransient low blood pressure was common in children undergoing cardiac MRI with anaesthesia, but the incidence of hypotension did not differ between ferumoxytol and gadolinium groups. The use of ferumoxytol was associated with significantly shorter scan time and anaesthesia duration, as well as a decreased need for airway intervention.
Device Testing and Programming at Implantation

This chapter outlines a step-by-step description of Implantable Cardioverter-Defibrillator (ICD) testing and programming at the time of initial implantation. The principal devices available for use in the United States will be discussed along with our professional medical opinion regarding device testing and programming based on patient presentation. It goes without saying that our preferences do not define the only appropriate strategies.
Neurobehavioral Analysis of Epilepsy in Developmentally Disabled Individuals

Behavior analysis requires a deterministic viewpoint. By refining the conditions under which an individual is studied, the noncapricious functional relations between the environment and behavior can be obtained. For example, Pavlov (1927) and Skinner (1938) refined their experiments to the point where a single manipulation of an independent variable was sufficient to reveal a behavioral function. The occurrence of epileptiform neurophysiological activity can be analyzed from the same deterministic viewpoint. The functional relations of overt behavior, neurophysiological behavior, and the environment can be empirically determined by concurrent EEG and behavior monitoring under controlled environmental conditions. This approach is called neurobehavioral analysis because it represents the specialized practice of behavior analysis in the neurophysiology laboratory. This chapter will review three areas of the neurobehavioral analysis of epilepsy in developmentally disabled individuals: the diagnosis of pseudoepilepsy, the effects of the environment on epilepsy, and the effects of epileptiform discharge on stimulus control of behavior.
Minimally Invasive Approaches to Treat Symptomatic Uterine Myomas

Uterine myomas are common in reproductive-aged women. Traditionally, treatment for symptomatic myomas in women wishing to preserve their ability to have children has been abdominal myomectomy. While this procedure is very successful in improving symptoms related to the myomas, it is associated with surgical morbidity, patient hospitalization, and a prolonged postoperative recovery. Newer, less invasive techniques are now available to treat symptomatic uterine myomas including laparoscopic and robotically assisted laparoscopic myomectomy, ­uterine artery embolizaiton, and MRI-guided ultrasound ­focused surgery. These techniques have the advantage of less morbidity and quick recovery. Many studies have shown promising results with regard to improvement in myoma-related symptoms. However, concerns have been raised about using these procedures for women who would like to become pregnant. Further studies are needed to evaluate the risks and benefits compared to standard treatment options.
Bayesian Methods for Genomics, Molecular and Systems Biology

Inference for high throughput genomic data has emerged as a major source of challenges for statistical inference in general, and Bayesian analysis in particular. This chapter discusses some related current research frontiers. The chapter highlights how specific strengths of the Bayesian approach are important to model such data. Bayesian inference provides a natural paradigm to exploit the considerable prior information that is available about important biological pathways. Another strength of Bayesian inference that leads to research opportunities with phylogenomic data is the natural ease of simultaneous modeling and inference on multiple related processes.
A U.S. perspective on China’s external economic disputes in the past 40 years and in the coming 40 years

On the disputes over China’s trade imbalance, (1) they were marked by analytical confusion over the meaning of the term “equilibrium exchange rate”; (2) China’s trade imbalance reflects the economic conditions in both China and abroad, and that the efficient and fair solution of the problem requires policy changes not only by China but also by the US; (3) the dispute on exchange rate misalignment has been a diversion away from (a) addressing the underlying structural factors causing the trade imbalance, and (b) improving the inadequacy of US job transition programs that has exacerbated US unhappiness with trade imbalance. On the industrial policy dispute, (1) the issue of forced technology transfer is largely a dispute about a large economy using its market power to benefit itself at the expense of its trade partners; (2) this use of market power is normally temporary because of the almost inevitable retaliation by other large countries; (3) notion of national security that is commonly adopted in the US trade policy debate is overly broad and short-sighted, and, unless these two aspects are corrected, they will hurt the US economy and weaken US national security in the long-run; (4) the US must reform the CFIUS (Committee on Foreign Investment in the United States) process of reviewing foreign acquisition of US technology by (a) making the process more comprehensive (e.g. setting up foreign-owned R&D centers in US) and (b) making the process more operational by a defining a list of technologies for CFIUS to cover, a list that is constantly updated. On China’s Belt Road Initiative (BRI), (1) as the number of BRI project grows and as the number of partner countries increases, the number of economic disputes that China will be involved in will grow; (2) China should ensure that the BRI projects in a country are beneficial to the general population of that country and not just politically-biased toward the government in power at that time because, unlike in China, most governments in other countries come and go more frequently; and (3) economic disputes are a systemic feature of the present uncoordinated multi-polar world. Our principal policy suggestion to China is that, because China’s economy in 2018 is very different from that in 1978, there should be more reciprocity in China’s trade and investment relations with the advanced economies. China should not only give national treatment in the near future to foreign firms but should also set up a mechanism to start easing up on foreign acquisition of Chinese firms in a manner that is consistent with China’s national security concerns. Our principal policy suggestion to the US is to stop equating strategic competition with economic competition. Strategic competition is normally a zero-sum game while economic competition is usually a zero-sum game in the short-run, but generally creates a win-win outcome in the long-run. National economic dynamism and economic resilience emerge from international economic competition and not from sheltering domestic high-tech firms permanently.
Prevalence and clinical phenotype of concomitant long QT syndrome and arrhythmogenic bileaflet mitral valve prolapse

Abstract Background Mitral valve prolapse (MVP), including the recently described arrhythmogenic bileaflet MVP syndrome (ABiMVPS), is associated with repolarization abnormalities and may represent an underestimated cause of sudden cardiac death. The impact of concomitant MVP or ABiMVPS on long QT syndrome (LQTS) clinical severity is unknown. Methods and results Retrospective review of 754 LQTS patients [445 females (58%) and mean QTc 471 ± 41 ms] with available echocardiographic data was performed to identify LQTS patients with not only MVP, but also a pro-arrhythmic ABiMVPS phenotype defined as bileaflet MVP, inferolateral T-wave inversions, and frequent complex ventricular ectopy/arrhythmia. As expected, 18/754 (2%) LQTS patients had concomitant MVP. Of these, 5/18 (28%) LQTS patients with MVP satisfied ABiMVPS diagnostic criteria. No difference in symptomatology, degree of QT prolongation, or clinical management was observed between LQTS patients with and without MVP. In contrast, LQTS plus ABiMVPS resulted in a severe cardiac phenotype as illustrated by symptomatic status (LQTS-ABiMVPS; 5/5; 100%; vs LQTS: 279/736; 39%; p = .008), degree of baseline QTc prolongation (LQTS-ABiMVPS: 536 ± 58 ms; vs LQTS: 470 ± 40 ms; p = .009), and number of patients experiencing ≥1 on-therapy break-through cardiac event (LQTS-ABiMVPS: 4/5; 80%; vs LQTS: 48/736; 7%; p Conclusions and relevance The co-existence of LQTS and ABiMVPS may lead to a rare, but malignant, clinical entity characterized by potentially life-threatening arrhythmias despite maximal LQTS therapy.
Stochastic Track Model for Tornado Risk Assessment in the U.S.

This paper presents the development of a stochastic tornado simulation model for the United States (US). The continental of the US is subjected to more than 1,000 tornadoes each year, causing significant financial losses and social disruption. Compared to hurricanes, the damage region of a tornado is relatively small and the probability of occurrence at a given location is extremely low. Therefore, it is not feasible to use solely the observed data or tracks to quantify the tornado risk for a given structure or a city that has not been affected by historical tornadoes. In this paper, a methodology for performing stochastic simulation of tornado tracks for the US is presented. The stochastic simulation framework consists of a genesis model, which utilizes the kernel density estimation to simulate the spawn locations of tornadoes. Statistical models for tornado parameters such as track length, path width and intensity, were calibrated using the tornado database maintained by the US National Oceanic and Atmospheric Administration (NOAA) Storm Prediction Center (SPC). The developed statistical models were used to simulate 1,000,000 years of tornado tracks. The simulated tornado parameters include the tornado occurrence rate, intensity (EF-scale), location, touchdown time, path length and path width. All these parameters are geographic dependent, meaning the parameters vary depending on the tornado spawn locations. The simulated spawn rates and other key parameters for the continental of the US are compared to the observations. Good agreements are observed between simulations and observations. To illustrate a potential use of the simulated tornado track database, a probabilistic tornado hazard analysis was performed for Moore, Oklahoma. The 50-year tornado hazard curves for three domain sizes are developed to assess the influence of the domain size on tornado risk.
Change in Collaborative Ties in a Children's Mental Health Services Network: A Clique Perspective.

ABSTRACTEffective mental health service delivery networks are organized around clusters of closely coordinated provider organizations, or organizational cliques. Yet, research overlooks conditions ...
Experimental investigation of condensation and freezing phenomena on hydrophilic and hydrophobic graphene coating

Abstract Graphene possesses exceptional electrical, mechanical, thermal, optical and chemical properties with potential for a wide range of applications. While most of the above properties are relatively well studied in past decade, it’s wetting phenomena and surface interactions with water molecules and droplets are still not understood. Graphene has potential for improving performance and saving energy in applications such as, frost delaying, aviation/transportation, and condensate harvesting. In the present study, surface engineering has been applied via graphene coatings to reveal new insight into condensation and freezing dynamics. The tests have been conducted in presence of non-condensable gases (air) at different relative humidity (RH), since RH significantly changes the nucleation energy barrier as well as the nucleation site density. Two sets of graphene coatings on quartz and silicon oxide surface were used to study the condensation and freezing dynamics. Droplet growth was followed by initial nucleation, direct growth, coalescence, and then sweeping off the surface. Later, the effect of ice bridging length, individual ice bridge velocity, and droplet diameter on frosting dynamics were explored for hydrophilic graphene surfaces. A ∼1.6× freezing delay was observed for the hydrophilic graphene coating at a temperature of 271 K and 40% RH compared to a temperature of 271 K and 60% RH. The hydrophobic graphene coating slows the inter-droplet wave propagation and delays frost formation at 60% RH compared to hydrophilic graphene coating. A maximum of ∼3.65× freezing delay was observed for InkJet-printed graphene (IPG) surface compared to hydrophilic graphene surface at the same freezing temperature due to fewer ice bridging instances and jumping droplet phenomenon. Both hydrophobic and hydrophilic graphene surfaces delay freezing compared to a plain silicon surface under same operating conditions. Moreover, the present study has found that surface energy play a more significant role in condensate harvesting compared to relative humidity. This result promises the applicability of engineered graphene surface for significant energy savings in frost delaying, thermal management, and condensate harvesting applications.
Poster: Understanding User's Decision to Interact with Potential Phishing Posts on Facebook using a Vignette Study

Facebook remains the largest social media platform on the Internet with over one billion active monthly users. A variety of personal and sensitive data is shared on the platform, which makes it a prime target for attackers. Increasingly, we see phishing attacks that take advantage of users' lack of security knowledge, deceiving victims by using fake or compromised accounts to share malicious posts. These attacks may slip undetected by the Facebook defense system, exposing users to potentially be phished or have their devices infected with drive-by downloads and malware. Only a few studies have been conducted to date to understand how users interact with attacks like this in Facebook. In our prior work, we conducted a study to address this challenge using a simulated interface and think-aloud protocol. In this study, we aim to make further progress in understanding the impact of different factors on users' clicking decision in social media through a vignette study that encourages participants to think about realistic scenarios that they might face.
Effect of alcohol and alcoholic beverages on meal-stimulated pancreatic secretion in humans

Alcohol and alcoholic beverages may have different effects on pancreatic secretion and hormone release in humans. To test this hypothesis we studied the effects of an alcohol solution and a glucose solution and compared them with those of alcoholic beverages on postprandial pancreatic secretion and release of gastrin, trypsin, and cholecystokinin in 6 healthy nonalcoholic male volunteers. Pancreatic enzyme secretion was measured in duodenal aspirate, plasma trypsin, and gastrin by radioimmunoassay and cholecystokinin by bioassay. The meal plus glucose significantly stimulated pancreatic enzyme secretion, release of gastrin and cholecystokinin, and caused no changes in plasma trypsin. The alcohol solution and all beverages added to the meal caused similar increases in alcohol blood levels and significantly less pancreatic enzyme secretion compared with the meal plus glucose. Plasma trypsin levels remained unchanged. Compared with the meal plus glucose, wine and beer caused a significantly higher release of gastrin, and beer also released significantly more cholecystokinin. Inhibition of pancreatic enzyme secretion stimulated by a meal in nonalcoholics is a common effect of alcohol and alcoholic beverages despite some differences on release of gastrointestinal peptides. This effect may have some implications in the pathogenesis of alcoholic pancreatitis.
Maintenance, Repair, and Operations Parts Inventory Management in the Era of Industry 4.0

Abstract This paper discusses the challenges in Maintenance, Repair, and Operations (MRO) parts inventory management and how Industry 4.0 technologies can be leveraged to address them. Additive manufacturing, Internet of Things (IoT), big data analytics, machine learning, and new smart mobility logistics models are emerging technologies that enable efficient inventory solutions for different types of MRO parts. There is no single universal strategy that works for all MRO parts due to wide variety of part attributes including usage patterns, lead-time, and cost. In this paper, we propose the clustering of MRO parts into different groups and discuss the potential strategy to improve inventory management efficiency by leveraging emerging technologies for each MRO part group.
Evaluation of heat and pH treatments on degradation of ceftiofur in whole milk

Waste milk feeding practices have been implicated as a potential source for disseminating antimicrobial resistant bacteria among animals and the environment. Feeding dairy heifers raw milk with low concentrations of antimicrobials increases the proportion of antimicrobial resistance. Two potential interventions to degrade antimicrobial drugs in milk are heat and pH treatment. The aim of this study was to evaluate the effect of heat and pH treatments on the degradation of ceftiofur and ceftiofur free acid equivalents (CFAE) in milk at concentrations previously found in waste milk on dairy farms
Time- and Dose-Dependent Effects of Pulsed Ultrasound on Dermal Repair in Diabetic Mice

Chronic wounds, including diabetic, leg and pressure ulcers, impose a significant health care burden worldwide. Some evidence indicates that ultrasound can enhance soft tissue repair. However, therapeutic responses vary among individuals, thereby limiting clinical translation. Here, effects of pulsed ultrasound on dermal wound healing were assessed using a murine model of chronic, diabetic wounds. An ultrasound exposure system was developed to provide daily ultrasound exposures to full-thickness, excisional wounds in genetically diabetic mice. Wounds were exposed to 1 MHz ultrasound (2 ms pulse, 100 Hz pulse repetition frequency, 0-0.4 MPa) for 2 or 3 wk. Granulation tissue thickness and wound re-epithelialization increased as a function of increasing ultrasound pressure amplitude. At 2 wk after injury, significant increases in granulation tissue thickness and epithelial ingrowth were observed in response to 1 MHz pulsed ultrasound at 0.4 MPa. Wounds exposed to 0.4 MPa ultrasound for 3 wk were characterized by collagen-dense, revascularized granulation tissue with a fully restored, mature epithelium. Of note, only half of wounds exposed to 0.4 MPa ultrasound showed significant granulation tissue deposition after 2 wk of treatment. Thus, the db+/db+ mouse model may help to identify biological variables that influence individual responses to pulsed ultrasound and accelerate clinical translation.
VORTEX PROPAGATION IN DISCRETE JOSEPHSON RINGS

Superconducting systems built of underdamped Josephson junctions are of interest for ballistic and quantum vortex experiments. The dissipation in a Josephson tunnel junction can be extremely small because its subgap resistance can easily be made of the order of 1 MΩ which for a typical junction translates into a McCumber parameter as high as 107. In a Josephson system with such little dissipation, the vortex velocity can be high enough so that the energy stored in the electric field generated by the moving vortex has to be taken into account. This electric field contribution to the energy acts like a kinetic-energy term and the vortex mass is found to be proportional to the junction capacitance [1, 2, 3]. Measurements have indicated the existence of a mass term in the equation of motion for a vortex [4, 5]. The concept of a massive vortex has also been tested in quantum experiments: there is evidence for quantum tunneling of vortices [4, 5], for a collective, quantum phase transition triggered by a Bose-condensation of vortices [6], and for vortex interference (Aharonov-Casher effect) [7].
Balance and sustainability in multi-aged stands: a northern conifer case study

Foresters in the Northeast are both blessed and cursed by the inherent complexity of the region's forests. Thousands of years may pass between natural stand-replacing disturbances, though partial disturbances, such as blowdown, defoliating insects, and various forms of partial cutting, are common (Seymour 1995). Foresters in the region typically deal with multiaged stands and often seek to maintain or enhance structural diversity through selection cuttings. Selection forestry is complicated and prone to misapplication, however, especially in the mixed-species stands that dominate this landscape.
A Sense of Story: Interactive Journal Writing in Kindergarten.

Journal writing is a way to encourage process writing which promotes a sense of story. Written interactions or dialogues between the child and the teacher can support the story as children are involved in the writing process. The article describes one way to support the development of a story through journal writing. Children begin the story on their first page of the journal. The teacher responds in writing and the child subsequently converses with the teacher to produce stories and personal narratives. The written conversation helps children produce a story with a sense of meaning. Suggestions for kindergarten teachers and teacher education students include how to create the journal, what the writing center looks like, the necessity for a long-term commitment to writing, the importance of verbal and written interactions, and directions for beginning the interactive journal writing experience.
Coherent obliquity band and heterogeneous precession band responses in early Pleistocene tropical sea surface temperatures

[1] The nature of the connection between high- and low-latitude climates during the early Pleistocene “41 kyr world” has important implications for our understanding of the feedbacks involved in translating insolation changes into global climate states. Here we focus on the tropical marine record, presenting alkenone-derived sea surface temperature (SST) and productivity records from the eastern equatorial Atlantic, eastern equatorial Pacific, the Arabian Sea, and the South China Sea for a time interval covering the heart of the 41 kyr world (1.2–2.0 Ma). All four SST records are dominated by variance in the obliquity band, suggesting that high-latitude dynamics and low-latitude climate were tightly coupled in the 41 kyr world, despite smaller ice volume variability during this interval as compared to the late Pleistocene. At the 41 kyr period, SST varied coherently and nearly synchronously between the four study regions, suggesting a tropic-wide feedback to high-latitude processes. Productivity variations at our equatorial Atlantic and Pacific sites were also coherent in the obliquity band, implying tropical trade wind variability at this frequency during the early Pleistocene. In contrast, we observe heterogeneous SST and productivity responses in the precession band between each of the tropical locations. Local atmospheric circulation patterns, rather than a globally coordinated response to precessional insolation forcing, apparently determined SSTs and productivity in the tropics at precessional frequencies during the early Pleistocene.
Power delivery, signaling and cooling for 2D and 3D integrated systems

As gigascale integrated (GSI) technology progresses beyond the 45 nm generation, the performance of a monolithic system-on-a-chip (SoC) has failed by progressively greater margins to reach the “intrinsic limits” of each particular generation of technology [1]. The root cause of this lag is the fact that the capabilities of monolithic silicon technology per se have vastly surpassed those of the ancillary or supporting technologies that are essential to the full exploitation of a high-performance SoC. The most serious obstacle that blocks fulfillment of the ultimate performance of an SoC is inferior heat removal.