cssi/SciSciGPT-SciSciNet huggingface dataset:
Obstetrical venous thromboembolism: Epidemiology and strategies for prophylaxis

Venous thromboembolism (VTE) is a leading cause of severe maternal morbidity and mortality. While pregnancy alone is a risk factor for VTE, additional population-based risk factors such as obesity are becoming increasingly common, particularly in the developed world. Maternal death from VTE is amenable to prevention and VTE thromboprophylaxis is the most readily implementable means of systematically reducing the maternal death rate. In the United States, prophylaxis is recommended primarily for patients at extremely high risk for thromboembolism and women undergoing cesarean delivery, whereas in the United Kingdom a larger proportion of the population is targeted. Given the maternal burden of obstetric VTE and varying strategies for prevention, this article will provide a review of the following topics: (1) global epidemiology of obstetric VTE, (2) prophylaxis guidelines in the United States and the United Kingdom, and (3) maternal mortality from VTE in the United States and the United Kingdom in the setting of differing prophylaxis strategies.
Assessing the Impact of School-Based Marketing Efforts: A Case Study of a Foreign Language Immersion Program in a School-Choice Environment

The marketization of K–12 education has led to an increase in school-based marketing efforts. Relatively little research, however, has examined how public schools market themselves, who is involved in marketing, and how these marketing efforts impact key stakeholders, including school administrators, teachers, students, and parents. We explore these questions in this qualitative study of school-based marketing efforts at South Boulevard,1Because of the long and public history of desegregation litigation associated with the school and with the school district, we use real place names throughout the paper. Thus, we disclose both the school's name—South Boulevard Foreign Language Academic Immersion Magnet—and the name of the city in which the school is located—Baton Rouge, Louisiana, in order to maintain the authenticity of the case and the findings. a foreign language immersion magnet elementary school in East Baton Rouge Parish, Louisiana. Analysis of data from participant observation and in-depth intervie...
Domestic violence: teaming communities with providers for effective intervention.

For battered women, it is essential that health care providers begin to address the causes of domestic violence injuries--not just the result. Community involvement is necessary for the interventions to be effective, and the health care system is uniquely positioned to intervene as the universal point of entry for abused women. The article outlines some of the challenges in addressing domestic violence, identifies barriers to addressing the problem, and offers suggestions for overcoming the barriers in the current health care environment. Language: en
Management of women with multiple sclerosis through pregnancy and after childbirth

Multiple sclerosis (MS) is a major acquired neurologic disease of young adults. The prototypic patient is a young woman of reproductive age. Gender preference is becoming more pronounced, since MS is increasing specifically among women. Any healthcare provider who deals with MS must be prepared to discuss pregnancy issues, and provide appropriate counseling. This is now complicated by the availability of multiple treatment options. There is growing literature on which to base recommendations, particularly regarding washout periods. After a brief background introduction, this review will discuss state-of-the-art family planning counseling in the treatment era, divided into prepregnancy, pregnancy, and postpartum MS issues.
PI in STM resulting from the semantic similarity of items

Two experiments were performed to test the hypothesis that semantic similarity does not give rise to interference in STM. In both experiments a Peterson and Peterson type of STM task was used in which the Ss were required to recall three words after some intervening activity. All Ss were required to recall three sets of words. The last set was the critical test series and was identical for the experimental and the control groups. However, for the experimental group the first two series were semantically similar to the test series, whereas the control group had semantically dissimilar items. In both experiments the control group showed better recall than the experimental group, indicating that semantic similarity does in fact give rise to PI in STM.
DATING FREQUENCY AMONG HIGH SCHOOL SENIORS

Sumntcrry.-This st~dy was undertaken to re-examine several variables noted in literature as theoretically related to dating frequency among high school seniors. Scholastic aptitude and achievement and school-related activities were negatively related or unrelated to dating frequency. A job, a car, and plans for marrying younger were psitively related to dating frequency, but contrary to expectations, SES was not. Research indicates that older students tend to date more than younger students, (12), that students who start to date at an earlier age will date more frequently at later ages (2, 12, 13, 15) and that although there is no difference in dating frequency between boys and girls as freshmen, senior girls do tend to date more often than senior boys (12, 14). It has also been shown that the clique or "gang" is important in dating frequency (4, 9). Evidence also suggests that students from higher social class or socioeconomic status (SES) levels date more frequently than those from lower levels. Ic has also been suggested that school-related activities and dating compete for students' time (3, 7). Thus, those who do well in school are often not among the frequent daters, and vice versa. Frequency of dating has been shown to be positively related to steady-dating habits
Performance characteristic of endoscopic ultrasound-guided fine needle aspiration is unaffected by pancreatic mass size

Background and study aims: Despite a well-established tool for diagnosis of pancreatic masses, endoscopic ultrasound-guided fine needle aspiration (EUS-FNA) studies have shown suboptimal diagnostic performance at divergent mass sizes. Since the impact of gold standard follow-up and presence of on-site evaluation on this observation is unknown, we aimed to study the performance characteristics of EUS-FNA under these strict conditions. Patients and methods: EUS-FNA results from pancreatic mass lesions performed between July 2000 and March 2013 were evaluated. All patients with histological follow-up were then stratified into four groups: Group A ( ≤ 10 mm), Group B (11 – 20 mm), Group C (21 – 40 mm), and Group D (> 40 mm). Sensitivity and diagnostic accuracy were calculated for each group and compared. Results: A total of 612 /3832 (16 %) patients with pancreatic masses who underwent EUS-FNA had histology confirmation. Of these, 81 were excluded due to unavailable lesion size, while the rest formed the study cohort. Mean age (SD) was 65.8 years (9.3) with 51.2 % female. The mean number of passes for the entire cohort was 2.9 (SD 1.9; range 1 – 12); patients in group D had a significantly higher number of passes for on-site diagnosis ( P = 0.0124). There was no significant difference between the groups for sensitivity ( P = 0.1134) or diagnostic accuracy ( P = 0.2111). Proportional trend analysis revealed no significant correlation between size and sensitivity ( P = 0.6192). The size of lesion measured by EUS was not associated with sensitivity or specificity after adjusting for age, sex, and pancreatic location. Conclusion: In the presence of rapid on-site cytopathology and when final histology is taken as the gold standard, pancreatic mass size does not affect the performance characteristics of EUS-FNA.
Telepractice and the Public Sector Audiologist

The American Speech-Language-Hearing Association (ASHA) defines telepractice as the application of telecommunications technology to deliver professional services at a distance by linking clinician ...
Introduction to Game Physics with Box2D

Written by a pioneer of game development in academia, Introduction to Game Physics with Box2D covers the theory and practice of 2D game physics in a relaxed and entertaining yet instructional style. It offers a cohesive treatment of the topics and code involved in programming the physics for 2D video games. Focusing on writing elementary game physics code, the first half of the book helps you grasp the challenges of programming game physics from scratch, without libraries or outside help. It examines the mathematical foundation of game physics and illustrates how it is applied in practice through coding examples. The second half of the book shows you how to use Box2D, a popular open source 2D game physics engine. A companion website provides supplementary material, including source code and videos. This book helps you become a capable 2D game physics programmer through its presentation of both the theory and applications of 2D game physics. After reading the book and experimenting with the code samples, you will understand the basics of 2D game physics and know how to use Box2D to make a 2D physics-based game.
The inferior epigastric arteries as coronary bypass conduits. Size, preoperative duplex scan assessment of suitability, and early clinical experience.

We are currently evaluating the inferior epigastric artery as an alternative arterial conduit for coronary bypass grafting. Fifty-seven inferior epigastric arteries were harvested from 47 adults. There were no differences in size between the right and left inferior epigastric arteries. Diameter was 2.5 to 3.5 mm proximally and 2 to 3 mm distally. Usable length was 6 to 16 cm (mean 11.2 ± 0.25 cm). Grade I/IV atherosclerosis was found in one patient (2.1 %). Duplex scanning was used for preoperative evaluation of the inferior epigastric arteries in 51 patients. In 21 patients the arteries were not harvested, in part because of duplex scan findings of small caliber or early bifurcation. In 30 patients the duplex findings could be compared with the surgical findings. The average length at operation was twice the length detected on duplex scan (11.2 cm versus 5.8 cm, p horac C ardiovasc S urg 1992;103:463-5)
Towards Better Accounting of Physical Design Effects in High-Level Synthesis

High level synthesis has long relied on point models for RT level components, where the area and delay of a component are assumed to be constant for a given style. Nowadays, many synthesis algorithms attempt to incorporate physical design information into the design process so as to better guide the synthesis tasks. In this work, we explore the combined effect of style and aspect ratio variations on the area and delay of RT level components, and on RT level designs which use such components. Our results indicate that point models are inadequate for use in the synthesis process due to the large variations in the area and delay that occur when component styles and aspect ratios are varied. We believe that our results have some deep implications with respect to the flow of the design tasks during high level synthesis.
New Paradigm of Social Poster Embedding Unexpected Graphic Pattern for the Ongoing Issue, Radiation Contamination in Fukushima

A poster must be sufficiently informative to convey a suitable message which reflects the genuine characteristics of the topic. A social poster design deals with social issues, which are not instantaneous events where existing in a dynamic society. Therefore, the social poster design has to represent the continuous consequences due to the social incident. On 11 March in 2011, a magnitude 9.0 earthquake hit off the east coast of Japan, caused 15,821 deaths, 3,962 missing, and 5,940 injuries in 20 Japanese prefectures as reported by The National Police Agency of Japan (Dunbar et al., 2011). Though the earthquake, aftershocks and tsunamis ended, it is an unfinished tragedy, due to the continuous exposure of the radioactive contaminated water by the Fukushima Daiichi plant. The highly contaminated water has accumulated on roofs and it keeps flowed into the Pacific Ocean when it rains (McCurry, 2015). This study aims to present the ongoing impact of radioactive materials to our society on a social poster through an animated graphic. The randomly created background patterns within the poster, symbolize the unfinished radioactive leaking and its circulation in our environment. Hence, this poster is a dynamically changing rather than a static graphic poster, much like the continuous changes occurring within the environment, due to the Fukushima event. In the middle, the red solid circle not only reflects the Japanese flag but also symbolizes the contaminated Earth. For the background patterns, I generated the random motion of oblique lines by computer programming using Processing, which is an open source programming language. The randomly generated graphic by Processing, referred to as animated graphic, exhibits the unexpected radioactive exposures due to the Fukushima Daiichi nuclear disaster. The red circle represented Japan and the Earth suffered by the ongoing contamination that it was depicted by transparent red that the symbol and the patterns are overlapped and coexist. It should be noted that the printed version of the poster is captured from the digital work, which can be found at https://dl.dropboxusercontent.com/s/ulcosh5dpm1xw85/index.html?dl=0. The animated graphic shown in the dynamic poster, informs an audience of the ongoing social issue that the radioactivity which has been leaking into the ocean since the Fukushima Daiichi nuclear disaster in 2011. Unlike a traditional, static print poster, it raises the audiences' awareness, empathy and understanding of the tragedy using dynamic data, affecting a different reaction.
The Role of Spinal Manipulation in the Treatment of Low Back Pain

Although approximately 200 treatment options are available to treat low back pain,1 no single treatment is clearly superior. Furthermore, the etiology of back pain is often unclear, possibly contributing to treatment strategies for low back pain often being determined by preferences of the clinical care practitioner. Spinal manipulative therapy (SMT) is a controversial treatment option for low back pain, perhaps in part because it is most frequently administered by chiropractors. Chiropractic therapy is not widely accepted by some traditional health care practitioners. This may be, at least in part, because some early practitioners of chiropractic care rejected the germ theory, immunizations, and other scientific advances.
The ecology, behavior, and conservation of the tidewater goby, Eucyclogobius newberryi

Understanding the ecology and behavior of endangered species, such as the tidewater goby, Eucyclogobius newberryi, is important for identifying problems and formulating solutions for species recovery. The tidewater goby forms isolated populations in California's coastal lagoons, creeks, and marshes. Rapid declines in the number of populations led to its listing as an endangered species in 1994. This benthic fish prefers stillwater habitats and feeds on small invertebrates. It is an annual species with an extended breeding season. Fish are larger in marsh habitats than in lagoon or creek habitats. The male digs a spawning burrow, preferably in sand, where he provides care for a single clutch. The tidewater goby is sex-role reversed: females compete more intensely than males for access to mates. The tidewater goby is a species at risk, in part due to narrow habitat preferences, isolation of populations, short lifespan, lack of marine dispersal, and vulnerability to introduced predatory fishes. Attributes that favor its recovery include euryhaline tolerances, rapid reproductive rate, its potential for opportunistic feeding, and the possibility of natural recolonization under certain circumstances. Potential conservation measures include protecting coastal marshes that adjoin creeks and lagoons, maintaining natural hydrologic regimes, preventing artificial breaching of the sandbar at the estuary's mouth, and preventing introductions of predatory fishes. Captive breeding and reintroduction of tidewater gobies are potential tools for recovery, provided that underlying problems of habitat availability and suitability and issues of genetic integrity and disease transmission are addressed. Further research into the tidewater goby's utilization of marsh habitats, dispersal mechanisms, response to artificial breaching events, and metapopulation genetics would provide additional information for management.
Drawn and Written Funds of Knowledge: A Window into Emerging Bilingual Children's Experiences and Social Interpretations through Their Written Narratives and Drawings.

This qualitative study examines Mexican-American emerging bilingual children’s depictions of their lives in the form of written narratives and drawings as a window into their own understandings and...
In adults, benzodiazepines were not linked to increased risk for mortality at 6 mo but were linked at 12 and 48 mo

Source Citation Patorno E, Glynn RJ, Levin R, Lee MP, Huybrechts KF. Benzodiazepines and risk of all cause mortality in adults: cohort study. BMJ. 2017;358:j2941. 28684397
Exosomes derived from B16F0 melanoma cells alter the transcriptome of cytotoxic T cells that impacts mitochondrial respiration.

While recent clinical studies demonstrate the promise of cancer immunotherapy, a barrier for broadening the clinical benefit is identifying how tumors locally suppress cytotoxic immunity. As an emerging mode of intercellular communication, exosomes secreted by malignant cells can deliver a complex payload of coding and noncoding RNA to cells within the tumor microenvironment. Here, we quantified the RNA payload within tumor-derived exosomes and the resulting dynamic transcriptomic response to cytotoxic T cells upon exosome delivery to better understand how tumor-derived exosomes can alter immune cell function. Exosomes derived from B16F0 melanoma cells were enriched for a subset of coding and noncoding RNAs that did not reflect the abundance in the parental cell. Upon exosome delivery, RNAseq revealed the dynamic changes in the transcriptome of CTLL2 cytotoxic T cells. In analyzing transiently coexpressed gene clusters, pathway enrichment suggested that the B16F0 exosomal payload altered mitochondrial respiration, which was confirmed independently, and upregulated genes associated with the Notch signaling pathway. Interestingly, exosomal miRNA appeared to have no systematic effect on downregulating target mRNA levels. Databases Gene expression data are available in the GEO database under the accession SuperSeries number GSE102951.
System Reliability Benefits of Repetitive Framing in Cold-Formed Steel Floor Systems

AbstractTypical cold-formed steel floor systems involve many repetitive joist members laid in parallel, yet the design specifications are based upon the reliability of individual members and fail t...
An infrared beam combiner for wavelength bootstrapping at the NPOI

Since 1994, the Navy Precision Optical Interferometer (NPOI) has operated at visual wavelengths (450 to 850 nm). Its primary Classic backend is a pupil-plane combiner that disperses the light at a resolution R ≈ 50, uses avalanche photo-diodes as photon-counting detectors, and scans interference fringes by modulating the delay at 1 kHz. The newer NPOI image-plane combiner, VISION (Tennessee State University), which is similar to CHARA’s MIRC and is currently being upgraded, dispenses with delay modulation. We are now developing a third backend to expand into the near infrared. Its primary purpose will be to stabilize the NPOI for high-resolution observations by bootstrapping from the infrared to visual wavelengths.
Resonance Raman Spectroscopic Characterization of the Oxidation of the Horseradish Peroxidase Active Site

Enzymes containing heme prosthetic groups (heme enzymes) are an extensive class of biological catalysts. These enzymes possess differing reactivities and specificities, even though they contain a very similar active site heme group, which is in many cases an unmodified iron-bound protoporphyrin IX. Some heme enzymes of current interest include cytochrome P-450, cytochrome oxidase, tryptophan pyrollase, prostaglandin synthase, secondary amine mono-oxygenase, ligninase and the various peroxidases and catalases [1–3]. The ability of the heme enzymes to mediate reactions involving oxygen is of importance to industrial applications and health related areas [4].
Cooperation and Conflict among Democracies: Why Do Democracies Cooperate More and Fight Less?

The purpose of this paper is twofold: (1) to corroborate that democracies rarely fight other democracies, and (2) to establish why. The paper shows that democracy-pairs cooperate more and fight less in order to protect the greater amounts of trade and wealth that democracies exhibit. Unlike current studies that employ war and militarized international dispute (MID) data, this analysis is performed using the Cooperation and Peace Data Bank (COPDAB), an events data set culled from 48 newspapers from 1958 to 1967. As such it utilizes information on both international cooperation and conflict, and thus is not restricted solely to conflict data as in most studies. The results are important because they provide an alternative, more economics-based, explanation of why democracies rarely fight each other, rather than the “cultural” and “structural” reasons now commonly used in the political science literature. As such, the results call to question current U.S. policies that promote democratization to establish peace. The paper shows free trade to be a more fundamental factor in the peace process than democracy per se, and as such the paper advocates policies encouraging international trade rather than policies purely advocating democratization.1
Stochastic Small Signal Stability of Power System with Random Wind

We study the small signal stochastic stability of an electric power system with variable wind energy. Random wind speed is shown to appear as a multiplicative parametric uncertainty in the linearized differential-algebraic description of the power system dynamics. Recent results on the stochastic stability of linear systems with multiplicative uncertainty allow us to characterize a critical variance of wind speed, beyond which the grid dynamics becomes mean square unstable. We illustrate the role of mean square stability and the critical variance through simulations on the IEEE 39-bus system.
Analysis of predictor variables for mosquito species identification from dual-wavelength polarization-sensitive lidar measurements

Mosquito-borne diseases are a major challenge for Human health as they affect nearly 700 million people every year. Monitoring insects is generally done through trapping methods that are tedious to set up, costly and present scientific biases. Entomological lidars are a potential solution to remotely count and identify mosquito species and gender in realtime. In this contribution, a dual-wavelength polarization sensitive lidar is used in laboratory conditions to retrieve the wingbeat frequency as well as optical properties of flying mosquitoes transiting through the laser beam. From the lidar signals, predictive variables are retrieved and used in a Bayesian classification. This paper focuses on determining the relative importance of the predictive variables used in the classification. Results show a strong dominance of the wingbeat frequency, the impact of predictive variables based on depolarization and backscattering ratios are discussed, showing a significant increase in classification accuracy.
Memory of Love Towards Parents Questionnaire: Development and Psychometric Evaluation.

We document the development of the Memory of Love towards Parents Questionnaire—for use in multiple areas of psychology. It is designed to measure current feelings of and memory of love towards a s...
Some investigations of metre-wave radio propagation in the trans-horizon region

Investigations have been made of the characteristics of metric radio transmissions in the trans-horizon region, at ranges up to 400 nautical miles. These indicate the essentially continuous existence of troposphere-supported signal components in this region, although their detailed characteristics are subject to variations.Under particular meteorological conditions, such as the formation of an elevated inversion layer, an additional propagation mode is present, leading to a composite signal at intermediate ranges.
Virtual Truck Driver Training and Validation: Preliminary Results for Range and Skid Pad

This poster presentation will describe preliminary work done at the Carnegie Mellon Driver Training and Safety Institute (CM-DTSI) to test the validity of truck driver simulator training for backing maneuvers, and the digitalization of a skid pad. Preliminary results supported the validity of simulator training for straight-line and reverse-lane-change backing skills. Results for the skid pad work indicated that stopping distances during hard braking on the virtual skid pad were somewhat shorter than on the physical skid pad at the same initial speed. The shorter stopping distance in the simulator was the result of the functional limit of 0.2 surface coefficient of friction in the simulation dynamic model. A virtual skid pad with a slope of 9% was created to test the effect of slope on braking distance. Results showed that stopping distances in the simulator increased as a result of increasing the slope, indicating that the functional limit of the dynamic model can be overcome by varying the virtual slope.
Hemorrhage after on-ECMO repair of CDH is equivalent for muscle flap and prosthetic patch

Abstract Background/Purpose Prosthetic patch (patch) and muscle flap (flap) techniques are utilized for severe congenital diaphragmatic hernia (CDH) repair; however, when performed on extracorporeal membrane oxygenation (ECMO), the risk of hemorrhage increases. We sought to compare bleeding complications between repair types. Methods We retrospectively reviewed 2010–2016 on-ECMO CDH repairs. Results Twenty-nine patients met criteria: 13 patch (44.8%) and 16 flap (55.2%). Eight patch (61.5%) and 13 flap (81.2%) patients had left-sided defects (p = 0.223). All defects were Type C or D (Type C: patch 53.8%, flap 56.2%, p = 0.596). There was no difference in gestational age at delivery (patch 37.5 ± 0.9 weeks, flap 37.2 ± 1.3 weeks, p = 0.390) or age at repair (patch 7.46 ± 6.6 days, flap 6.00 ± 4.3 days, p = 0.476). Seven patch (53.8%) and 9 flap (56.2%) patients survived to discharge (p = 0.596). Estimated intraoperative blood loss was equivalent (patch 35.3 ± 53.9 mL, flap 24.2 ± 18.4 mL, p = 0.443). One patch patient (7.6%) and two (12.5%) flap patients required reoperation in the first 48 h for bleeding (p = 0.580). 48-h postoperative transfusions were the same for those that required reoperation (patch 282.0 mL/kg, flap 208.5 ± 21.9 mL/kg, p = 0.054) and those that did not (patch 120.7 ± 111.7 mL/kg, flap 118.4 ± 89.9 mL/kg, p = 0.561). Conclusions On-ECMO bleeding complications are equivalent for both flap and patch CDH repair. Level of evidence Type III (retrospective comparative study)
Clinical features, molecular aberrations, treatments, and outcomes in histiocytic sarcoma.

7020Background: Histiocytic sarcoma (HS) is a rare and aggressive malignancy of the monocyte/macrophage lineage. There is a paucity of data on treatments and outcomes in HS. Methods: This is a retr...
How does one choose the appropriate pharmacotherapy for pediatric patients with functional dyspepsia

Dyspepsia in Greek means bad digestion. Functional dyspepsia (FD) refers to upper gastrointestinal (GI) symptoms (including epigastric pain or burning sensation, early satiety, and postprandial ful...
Design optimization for self-propulsion of a bulk carrier hull using a discrete adjoint method

Abstract Computational fluid dynamics (CFD) based optimization is becoming increasingly popular in hydrodynamic design of ship hulls because it provides a fully automatic framework with a shorter design cycle than a human-supervised design tool. Despite the above advantage, CFD-based optimization requires careful attention to relevant design considerations, such that the final design is useful in practice. These considerations include all relevant objectives (such as drag and wake distortion) and constraints (such as volume, thickness, and curvature). Although constraints have been included in previous hull shape optimization studies, these studies have typically considered only one objective. To address this shortcoming, we conduct design optimization for self-propulsion by simultaneously considering drag and propeller-wake distortion. We use a gradient-based optimization framework that includes a discrete adjoint method for efficient derivative computation, which allows us to use a large number of design variables to parameterize the complex hull shape and thus gain a large amount of freedom for geometric modification. We impose appropriate geometric constraints (volume, thickness, and curvature) on the hull surface to ensure a practical design. In addition, we use a weighted objective function that includes drag and wake distortion to construct a Pareto front with five optimizations. We also consider hull-propeller interaction by comparing optimization results with and without a propeller. We use the Japan bulk carrier (JBC) as the baseline model and focus on optimizing the stern region. We find that optimizing for only one objective results in a large penalty on the other objective, whereas a weighted objective balances the penalty and achieves simultaneous improvement in drag and wake distortion. Moreover, we observe that the suction effect of the propeller suppresses the flow separation near the bilge tube and smooths out the velocity distortion at the propeller plane; these are effects that would end up affecting the optimized shapes. Our results demonstrate that it is necessary to simultaneously consider drag and wake distortion in hull-shape-optimization studies, and that constrained shape optimization with a large number of design variables is possible with the discrete-adjoint method.
An infinite family of two-distance tight frames

The relationship between equiangular tight frames and strongly regular graphs has been known for several years. This relationship has been exploited to construct many of the latest examples of new strongly regular graphs. Recently it was shown that there is a similar relationship between two-distance tight frames and strongly regular graphs. In this paper we present a new tensor like construction of two-distance tight frames, and hence a family of strongly regular graphs. While graphs with these parameters were known to exist, this new construction is very simple, requiring only the existence of an affine plane, whereas the original constructions often require more complicated objects such as generalized quadrangles.
Safety, Tolerability, Pharmacokinetics, and Pharmacodynamics of a Liver-Targeting Acetyl-CoA Carboxylase Inhibitor (PF-05221304): A Three-Part Randomized Phase 1 Study.

PF-05221304 is a liver-targeted inhibitor of acetyl-CoA carboxylase, an enzyme that catalyzes the first committed step in de novo lipogenesis (DNL). This first-in-human study investigated safety/tolerability and pharmacokinetics of single and multiple ascending oral PF-05221304 doses, and fructose-stimulated DNL inhibition with repeated oral doses. Healthy subjects (n = 96) received single (1-240 mg) or repeated (2-200 mg daily) doses for 14 days or single 100-mg doses with and without food. PF-05221304 was well tolerated at all doses. Repeated PF-05221304 doses inhibited hepatic DNL in a dose-dependent manner, with near-complete inhibition seen at higher doses. With doses yielding ≥90% DNL inhibition, asymptomatic increases in fasting/postprandial serum triglyceride levels (≥40 mg/day) and declines in platelet count (≥60 mg/day) occurred; these were not observed at ≤80% DNL inhibition. Steady-state pharmacokinetics generally increased dose-proportionally, with a half-life of 14-18 hours and a minimal food effect on plasma exposure. The observed safety and tolerability, pharmacokinetics, and pharmacodynamics support the continued evaluation of PF-05221304 for the treatment of nonalcoholic steatohepatitis.
Embedded Librarianship Is a Winning Proposition.

A reference/instruction librarian used targeted outreach to furnish library services to faculty and students while assigned to work in the College of Education during a library renovation project. Due to the success of this temporary assignment, the author has subsequently maintained regular office hours in the College to provide research consultations for faculty and students, collaborate on collection development, and continue outreach efforts resulting in increased requests for research assistance and course-integrated information literacy instruction. The benefits and challenges of embedded librarianship in an academic department are also discussed.
Disrupting the educational racial contract of Islamophobia: racialized curricular expectations of Muslims in children’s literature

When racialized knowledge is built into curricular expectations in schools, children are susceptible to beliefs that lead them to a hierarchical understanding of social relationships with particula...
The effects of chemical treatment of whole canola seed on intake, nutrient digestibilities, milk production, and milk fatty acids of Holstein cows.

To determine the effect of alkaline hydrogen peroxide treatment of whole canola seed on milk fatty acid composition, 12 multiparous lactating Holstein cows (618 kg, 47 d in milk) were fed total mixed rations in a replicated (3) 4 x 4 Latin square designed experiment. The control diet contained no supplemental fat source. Canola seed (11.2%), either crushed or treated with alkaline hydrogen peroxide or Megalac® (5.6%) were supplemental fat sources in the crushed, treated, and calcium salts of long-chain fatty acids (Ca-LCFA) dietary treatments. Experimental periods consisted of 28 d, with 21 d of adaptation to diets and 7 d for data collection. Cows were offered ad libitum access to feed. Intakes, ruminal characteristics, and total tract apparent digestibilities were measured and are discussed. Production of milk and 4% fat-corrected milk were not different among treatment groups (average 35.0 and 32.8 kg/d, respectively). Milk fat percentages were greater (P =.02) for cows fed treated canola seed or Ca-LCFA than for cows fed crushed canola seed (average 3.71 vs 3.43 %, respectively), but milk fat yield (kg/d) was unaffected. Cows fed fat-supplemented diets had lower milk protein percentages than cows fed the control diet. Within the fat-supplemented diet groups, cows fed crushed canola seed had greater milk protein percentages (P =.01) and yields (P <.01) than cows fed treated canola or Ca-LCFA. Milk fat from cows fed diets supplemented with canola seed (treated or crushed) had lower proportions of 14:0 and 16:0 and greater proportions of 18:0 and 18:1 than milk fat from cows fed the control or Ca-LCFA diets. Intakes, milk production, milk composition, and milk fatty acid profiles substantiate that treated canola seed was utilized by cows to an extent similar to that of crushed canola seed. Further definition of the method for treatment of canola seed may provide a strategy for adding higher levels of monounsaturated fatty acids to lactation diets to produce favorable alterations in milk fat composition.
Eco-cultural Restoration of Riparian Wetlands in California: Case Study of White Root ( Carex barbarae Dewey; Cyperaceae)

This study defines the cultural and ecological significance of white root (Carex barbarae Dewey; Cyperaceae), and presents a template for eco-cultural restoration, drawing from both Traditional Ecological Knowledge and Scientific Ecological Knowledge. Carex barbarae is an herbaceous perennial understory plant in valley oak riparian woodlands, endemic to California and southern Oregon. Referred to as white root, C. barbarae is an indicator species of both cultural and ecological health. Two-thirds of the California Indian tribes within the range of white root historically tended and managed these sedges for basketweaving. Traditional management by Indian groups resulted in the creation and maintenance of homogeneous patches throughout low-elevation riparian forests of California, maintaining a lawn-like understory and a park-like physiognomy. Gathering and tending practices significantly influenced the distribution, quality and abundance of white root beds on species, community, and landscape scales. Understanding how indigenous people shaped their environment using Traditional Resource Management practices and related ecological effects is integral to successful contemporary restoration of riparian habitats. Understanding the reciprocal relationships between California Indians and their sovereign landscape is important to contemporary indigenous cultures and their identity, resilience, and vitality.
“We Cannot Have any Negativity”: A secondary analysis of expectancies for the experience of emotion among women with gynecologic cancer:

This study aimed to elucidate whether gynecologic cancer patients and their support persons have certain expectancies for emotion and whether these expectancies, if they exist, affect cancer-relate...
Alternative Protein Topology-Mediated Evolution of a Catalytic Ribonucleoprotein

The high-resolution structures of yeast RNase for mitochondrial RNA processing (MRP), a catalytic ribonucleoprotein (RNP), recently reported by Lan et al. and Perederina et al. illustrate how RNA-mediated selection of alternative protein conformations, sampled during stochastic excursions by polymorphic/metamorphic proteins, enabled RNAs and proteins to mutually influence their functional repertoires and shape RNP evolution.
Effect of Personal Innovativeness on Technology Adoption in Hospitality and Tourism: Meta-analysis

This study synthesizes existing empirical results about the effect of personal innovativeness on the intention to use technology in hospitality and tourism studies published from January 2010 to March 2020 via meta-analysis. The meta-analysis with a random effects model was conducted on 29 effect sizes of this relationship documented in 28 studies collected from over 7,000 search results on Google Scholar and Scopus. The results of the analysis suggest a significant positive medium effect of personal innovativeness on the intention to use technology in hospitality and tourism research with the overall effect size (ESr) of .38 (95% CI = .32, .44, z = 10.62, p = .001). The study also found that the effect does not change significantly across industries (hotels, restaurants, and tourism and travel), types of technology by task (with transaction function and without transaction function), age groups (younger than 30 years old and 30 years old and older), and power distance cultural differences of the respondents (high-power distance and low-power distance cultures). Based on the results of this study, the authors suggest adding personal innovativeness as a construct in technology adoption models in future research in hospitality and tourism studies and continue investigating potential moderations that could explain variations in effect sizes of the impact of personal innovativeness on the technology adoption intention across different populations. From the industry perspective, hospitality and tourism organizations may rely on customers with high perceived innovativeness to serve as change agents and drive customer adoption of new technology.
Cardiovascular Risk Assessment in Hypertensive Patients.

Hypertension is a highly prevalent and causal risk factor for cardiovascular disease (CVD). Quantititaive cardiovascular risk assessment is a new paradigm for stratifying hypertensive patients into actionable groups for clinical management and prevention of CVD. The large heterogeneity in hypertensive patients makes this evaluation complex, but recent advances have made CV risk assessment more feasible. In this review, we first describe the prognostic significance of various levels and temporal patterns of blood pressure. We then discuss cardiovascular risk prediction equations and the rationale of taking global risk into account in hypertensive patients. Finally, we review several adjunctive biomarkers that may refine risk assessment in certain patients. We observe that, beyond individual cross-sectional measurements, both short-term and long-term blood pressure patterns are associated with incident CVD; that current cardiovascular risk prediction performs well, and its incorporation into hypertension management is associated with potential population benefit; and that adjunctive biomarkers of target organ damage show the most promise in sequential screening strategies that target biomarker measurement to patients in whom the results are most likely to change clinical management. Implementation of quantitative risk assessment for CVD has been facilitated by tools and direct electronic health record integrations that make risk estimates accessible for counseling and shared decision making for CVD prevention. However, it should be noted that treatment does not return an individual to the risk of someone who never develops hypertension, underscoring the need for primordial prevention in addition to continued innovation in risk assessment.
TAT delivery of a PTEN peptide inhibitor has direct cardioprotective effects and improves outcomes in rodent models of cardiac arrest.

We have designed a cell-permeable peptide, TAT-PTEN9c, to improve cardiac arrest survival. It blocked endogenous PTEN binding to its adaptor and enhanced Akt signaling in mouse cardiomyocytes. It i...
Property to Race/Race to Property

In the United States, property and race shape each other. This has been true since colonization and is equally true today. First, property relationships shaped the distinct forms racism took for different racialized groups. Racism exists to explain and justify power and privilege of one group over another. But the goals of power and privilege vary across different groups, resulting in different stereotypes, legal and social barriers, and modes of control. This Article examines the racialization of African Americans, Indigenous peoples, ethnic Chinese, and racialized “off-White” ethnic groups to reveal the crucial role that a group’s relationship to valued resources plays in its distinct trajectory of racism. Second, racial relationships shaped property law for everyone in the United States. The power to foreclose for debts, the power of local governments to zone, the public goods attached to residence, the scope of the welfare state’s “new property”—in these areas and many more, efforts to control, exclude, and take from racialized groups changed what property means today. This Article reveals the hidden histories of racially neutral rules and shows how they have undermined the security and equitable distribution of property for all. Today, property law and rhetoric are often used to undermine measures that would increase the security, affordability, and autonomy that justify property in the first place. Revealing the racial roots of modern property rules, I hope, will create space for reform to achieve the liberatory and egalitarian norms that undergird our commitment to property.
A Systematic Review of the Biological Correlates and Consequences of Childhood Maltreatment and Adverse Childhood Experiences

Childhood maltreatment (CM) and adverse childhood experiences (ACEs) are two primary forms of interpersonal victimization that have been associated with a host of deleterious health outcomes. Studies over the past decade have begun to use a range of biologically informed methods to better understand the role biology plays in the relationship between CM, ACEs, and later life outcomes. This line of research has shown that both forms of victimization occur at sensitive periods of development, which can increase the likelihood of "getting under the skin" and influence health and behavior across the life course. This review examines the current state of knowledge on this hypothesis. One hundred and ninety-nine studies are included in this systematic review based on criteria that they be written in English, use a biologically informed method, and be conducted on samples of humans. Results reveal that latent additive genetic influences, biological system functioning captured by biomarkers, polygenic risk scores, and neurobiological factors are commonly associated with exposure and response to CM and ACEs. The implication of these findings for the existing body of research on early life victimization and recommendations for future research and policy are discussed.
Healthcare Worker Serious Safety Events: Applying Concepts from Patient Safety to Improve Healthcare Worker Safety.

Introduction Patient safety has improved pediatric healthcare by defining when patient safety events meet criteria as serious safety events (SSEs). Similar concepts apply to healthcare worker (HCW) safety. We describe the newly designed process for HCW injury reporting, the process for evaluating HCW SSEs, and early experience with the new systems. Methods The work to redesign our approach to HCW safety included 2 parts: (1) process flow mapping and redesigning the work for HCW injury reporting; and (2) creating a process to categorize HCW injuries and determine when such injuries rise to a HCW SSE level. We evaluated the mean time per month from HCW injury to reporting and compared those values during the postimplementation time. We also evaluated the team's experience with the first 4 potential HCW SSEs. Results By improving the process flow, the mean time to reporting decreased significantly from 28 days implementation time-period (September-October 2019) to 9 days during the postimplementation time-period (November 2019-May 2020) (P = 0.0002). Of the first 4 HCW events identified and reviewed as possible HCW SSE events, there were 2 defined as HCW SSE level 4, one defined as a precursor event, and one defined as a nonsafety event. Conclusion Adapting infrastructure and definitions used previously to improve patient safety can improve HCW safety.
“Straining Toward Communion”: Implications of Communion Theology

As Catholic institutions of higher education attempt to engage in conversations around the role and limits of civil law and canon law in their operations and mission, and at a time when shared governance requires deeper conversation with faculty, Trustees, and sponsoring religious congregations, an understanding of the nature and structure of the Catholic Church itself can prove instructive. The twentieth century model known as communion - the church as koinonia/ communion, a communion of communions - provides an informative resource for conversations about inclusion, partnership, Catholic identity, and mission in Catholic higher education in the twenty-first century. The medium of Catholic higher education can provide a critical forum for understanding multivalent expressions of communion ecclesiology and its implications, as well as the value and constraints of the var­ious interpretations that are currently operative.