cssi/SciSciGPT-SciSciNet huggingface dataset:
Toward a Song Code: Evidence for a Syllabic Representation in the Canary Brain

We show that presentation of individual canary song syllables results in distinct expression patterns of the immediate-early gene ZENK in the caudomedial neostriatum (NCM) of adult canaries. Information on the spatial distribution and labeling of stained cells provides for a classification of ZENK patterns that (1) accords to the organization of stimuli into families, (2) preserves the stimuli intrafamily relationships, and (3) confers salience to natural over artificial stimuli, resulting in a nonclassical tonotopic map. Moreover, complex syllable maps cannot be reduced to any linear combinations of simple syllable maps. These properties arise from the collective response of NCM neurons to auditory stimuli, rather than from the behavior of single neurons. The syllabic representation described here may constitute an important step toward deciphering the rules of birdsong auditory representation.
Oral and dental rehabilitation after mandible reconstruction

Certain criteria in relation to tissue support must be met before the placement of a mandibular prosthesis. These criteria are as follows: (1) adequate lingual and buccal vestibular depth, (2) appropriate load bearing tissues over the reconstructed mandibular alveolar ridge, (3) adequate mechanical and functional tissue retention of the prosthesis, (4) adequate oral opening, and (5) proper alignment of the reconstructed mandible in relation to the maxilla and temporal mandibular joints. The mandibular reconstruction patient may require preprosthetic surgical procedures before oral and dental rehabilitation. The most common of these procedures include vestibuloplasty and dental implant placement. Once the criteria are met, the patient can be restored to function and aesthetics with a fixed or removable prosthesis.
The characterization and role of aeolian deposition on water quality, McMurdo Dry Valleys, Antarctica

Abstract The connection of ecosystems by wind-driven transport of material has become a topic of increasing interest and importance. Less than 1% of dust transported worldwide is exported to the Southern Ocean and Antarctic cryosphere; however, aeolian transport on the Antarctic continent is predominantly locally derived from the abrasion of bedrock. The deposition of the aeolian material is integral to nutrient and solute dispersal in the Antarctic ecosystem. This is particularly true in the ice-free areas of Antarctica, such as the McMurdo Dry Valleys (MDV), where aeolian material deposited in the aquatic system is solubilized during the melt season. The material is predominantly locally-derived from the abrasion of bedrock. In this study, a two-step leaching experiment simulates the melt season and we quantify the flux of solutes and nutrients to the aquatic ecosystem. Soluble salts were removed from the aeolian material first during cold water leaching followed by an increase in carbonate and silicate dissolution during freeze–thaw. Major ion fluxes on glaciers and lakes are at least two orders of magnitude greater than nutrient fluxes. However, the fluxes derived from these experiments are less than the estimated flux from streams to lakes and probably represent minima. Aeolian redistribution of local soils is important because they are the only source of new solutes and nutrients to the aquatic ecosystem of the MDV.
Developing a hybrid software engineering curse that promotes project-based active learning

Software engineering courses typically introduce students to the fundamental principles used in this disciple area and provide students with an opportunity to demonstrate their understanding of these principles through the development of a software product. This session describes the author's experiences designing and implementing a hybrid software engineering course that incorporates elements from both traditional classroom and online learning environments. The classroom time saved by having students study and complete materials online is used by the instructor throughout the course to provide students with additional electronic and face-to-face feedback. An authentic business client, who provides students with an actual project for use in software development process, also participates in the course via the online environment.
Unaccompanied Homeless Youth: Intersections of Homelessness, School Experiences and Educational Policy

School districts are faced with the challenge of how best to serve the needs of a growing homeless student population. As the numbers of homeless children and youth continue to rise, it is imperative for educators and others to understand the experiences of unaccompanied homeless youth. A qualitative research project was undertaken to obtain the perspectives of six high school students experiencing homelessness. These perspectives illuminate the various and multiple factors intersecting with student's educational lives. Their narratives uncovered the following themes: (a) Homelessness as a misnomer, (b) Homelessness is not a choice, (c) Caring adults, and (d) Student agency. Their counternarratives challenge adults working with unaccompanied homeless youth to rethink and reimagine the manner in which homelessness is understood and framed; this is especially critical in educational spaces. Schools often are the primary contexts in which youth spend their time and can be instrumental to providing youth expe...
Programming Strategies for GPUs and their Power Consumption

GPUs are slowly becoming ubiquitous devices in high performance computing. Nvidia's newly released version 4.0 of the CUDA API[2] for GPU programming offers multiple ways to program on GPUs and emphasizes on Multi-GPU environments which are common in modern day compute clusters. However, despite of the subsequent progress in FLOP counts, the bane of large scale computing systems have been increased energy consumption and cooling costs. Since the energy (power X time) of a system has an obvious correlation with the user program, hence different programming techniques on GPUs could have a relation to the overall system energy consumption.
Effects of renal disease upon drug disposition.

Patients with poor renal function can have inappropriate responses to ordinary doses of many drugs. The reason is almost always an abnormality in the distribution, metabolism, or excretion of the drug leading to an inappropriate plasma concentration .of the drug for the dose. The true tissue sensitivity to drugs is usually normal in uremic patients.
In vitro and in vivo studies of electron beam evaporated titanium surfaces for orthopedic applications

Achieving stable device integration is challenging in orthopedic applications, particularly for prosthetic attachment, because of the many different hard tissue interfaces. Such osseointegrated devices undergo poor hard tissue integration caused by wear, lack of proper bone formation, and infection. The challenge with nanotextured titanium is to find a surface that prevents bacterial growth, while supporting bone cell proliferation to improve hard tissue integration. This study examined the influence of nanotextured titanium, with and without patterns, created through electron beam evaporation on bone formation and integration. In vitro and in vivo data provided data that these nanotextured surfaces improved bone growth compared to their conventional, non-nanotextured titanium surfaces.
A molecular phylogeny of North American atripliceae (Chenopodiaceae), with implications for floral and photosynthetic pathway evolution.

Abstract A phylogenetic investigation of American members of the tribe Atripliceae (Chenopodiaceae) was conducted to examine evolutionary patterns and ecophysiological change in the North American lineages. Molecular phylogenetic analyses including representatives of all American genera of Atripliceae and data from 18S–26S nuclear ribosomal (ITS, ETS) and cpDNA (3′trnK intron) sequences suggest that neither Atriplex, as traditionally recognized, nor the North American members of Atriplex constitute a monophyletic group. Congruence between well-supported nuclear and cpDNA clades and results of expanded leaf anatomical and isotopic analyses indicate that American taxa belong to two distantly related lineages with different photosynthetic pathways; only one shift from C3 to C4 photosynthesis is required to explain photosynthetic pathway evolution in sampled lineages of Atripliceae. Conservatism in photosynthetic pathway evolution in the tribe is exemplified by the endemic, C3 North American Atriplex taxa, wh...
Direct Measurement of AMPA Receptor Desensitization Induced by Glutamatergic Synaptic Transmission

Although almost all ionotropic neurotransmitter receptors undergo desensitization, the onset and recovery of desensitization at a synapse have never been observed directly. We have found changes in postsynaptic AMPA receptor sensitivity in neurons of the chick cochlear nucleus, the nucleus magnocellularis (nMAG), by photolysis of caged glutamate immediately after activation of a single synaptic input. Additionally, synaptic desensitization was demonstrated via competition between synaptically released glutamate and an exogenous nondesensitizing agonist, kainate. Both approaches indicated that at least 35-40% of the receptors were desensitized after a single synaptic stimulus. Miniature synaptic currents were depressed after an evoked synaptic current, indicating that desensitization led to a reduction in the response to individual transmitter quanta. Stimulation of adjacent glutamatergic inputs to the same cell demonstrated that nearby terminals did not depress one another, suggesting that the desensitizing level of glutamate is restricted to each axon terminal. These findings confirm that postsynaptic neurons may use desensitization to regulate the strength of transmission on a synapse-specific basis.
Strained-layer superlattices and strain-induced light holes

The capability of growing high quality strained-layer superlattices (SLS’s) from lattice-mismatched semiconductors opens up new opportunities in both basic and applied material sciences. This flexibility in the choice of SLS layer materials allows the study of quantum well effects in a variety of new and interesting heterojunction systems. In addition, the large tetragonal distortions of the SLS layers allow these structures to exhibit unique features which are not found in bulk semiconductors. An exciting example is the possibility of tailoring certain SLS materials so that they exhibit small two dimensional hole effective masses and enhanced low field hole mobilities at low temperatures and low carrier concentrations. Band structure calculations indicate that the layer strains, the direct band gap magnitudes of the layers, the valence band offset, and the hole energies all can play a role in determing these small two dimensional hole effective mass values.
Identification of Thlaspi caerulescens genes that may be involved in heavy metal hyperaccumulation and tolerance. Characterization of a novel heavy metal transporting ATPase.

Thlaspi caerulescens is a heavy metal hyperaccumulator plant species that is able to accumulate extremely high levels of zinc (Zn) and cadmium (Cd) in its shoots (30,000 μg g−1 Zn and 10,000 μg g−1 Cd), and has been the subject of intense research as a model plant to gain a better understanding of the mechanisms of heavy metal hyperaccumulation and tolerance and as a source of genes for developing plant species better suited for the phytoremediation of metal-contaminated soils. In this study, we report on the results of a yeast (Saccharomyces cerevisae) complementation screen aimed at identifying candidate heavy metal tolerance genes in T. caerulescens. A number of Thlaspi genes that conferred Cd tolerance to yeast were identified, including possible metal-binding ligands from the metallothionein gene family, and a P-type ATPase that is a member of the P1B subfamily of purported heavy metal-translocating ATPases. A detailed characterization of the Thlaspi heavy metal ATPase, TcHMA4, demonstrated that it mediates yeast metal tolerance via active efflux of a number of different heavy metals (Cd, Zn, lead [Pb], and copper [Cu]) out of the cell. However, in T. caerulescens, based on differences in tissue-specific and metal-responsive expression of this transporter compared with its homolog in Arabidopsis (Arabidopsis thaliana), we suggest that it may not be involved in metal tolerance. Instead, we hypothesize that it may play a role in xylem loading of metals and thus could be a key player in the hyperaccumulation phenotype expressed in T. caerulescens. Additionally, evidence is presented showing that the C terminus of the TcHMA4 protein, which contains numerous possible heavy metal-binding His and Cys repeats residues, participates in heavy metal binding. When partial peptides from this C-terminal domain were expressed in yeast, they conferred an extremely high level of Cd tolerance and Cd hyperaccumulation. The possibilities for enhancing the metal tolerance and phytoremediation potential of higher plants via expression of these metal-binding peptides are also discussed.
Olfactory system pathology as a model of Lewy neurodegenerative disease

Olfactory dysfunction has gained recognition as an early and nearly universal feature of Lewy body Parkinson's disease (PD). Recently, research efforts have focused on the use of early non-motor symptoms of PD as early biomarkers and have suggested that investigating neurodegeneration in the aspects of the nervous system subserving these symptoms may offer important insights into the pathophysiology of Lewy body PD. Therefore, there has been interest in characterizing the pathology observed in the olfactory bulb and system of patients with PD, dementia with Lewy bodies and perhaps more importantly, in subjects with incidental Lewy pathology, defined as people with Lewy pathology without evidence of Parkinsonism or dementia during life. The olfactory bulb may be ideally suited to investigations into the pathophysiology of the Lewy body disorders as it is one of the few areas of the brain wherein the entirety of neurons susceptible to Lewy neurodegeneration, including the dendritic arborization, cell soma, axon and synaptic terminals, can be examined in the same preparation. Interestingly, there is a lack of Lewy neurodegeneration in the dopaminergic neurons of the olfactory bulb and paradoxically, an apparent increase in dopaminergic neurons in some PD patients compared to controls. In this report, the known neuropathology of the olfactory system in PD will be reviewed and the advantages of investigating degeneration of the olfactory bulb as a model of Lewy neurodegeneration will be discussed.
Proton and Carbon‐13 NMR Studies of the Phencyclone Adducts of Medium Alkyl Chain‐Length N‐n‐Alkylmaleimides. Hindered Rotations and Magnetic Anisotropic Effects. Ab initio Calculations for Optimized Structures

Abstract The Diels–Alder adducts, 3a–e, of phencyclone, 1, have been prepared from a series of N‐n‐alkylmaleimides, 2, with medium chain‐length n‐alkyl groups. The maleimides were obtained by cyclodehydration of the N‐n‐alkylmaleamic acids, 4, formed from reaction of maleic anhydride with the corresponding n‐alkylamines. The five adducts prepared included derivatives from n‐heptyl, 3a; n‐octyl, 3b; n‐nonyl, 3c; n‐decyl, 3d; and n‐dodecyl, 3e. The NMR spectra of the adducts were studied in CDCl3 at ambient temperatures at 300 MHz for proton and 75 MHz for carbon‐13, with full proton assignments achieved by high‐resolution COSY45 spectra for the aryl and the alkyl regions. Slow exchange limit (SEL) spectra were observed for both 1H and 13C spectra showing slow rotation on the NMR timescales of the unsubstituted bridgehead phenyl groups. Endo Diels–Alder adduct stereochemistry was supported by striking magnetic anisotropic shielding effects in the 1H spectra of the alkyl groups, with the NCH2 CH 2 signal of ...
Retirement Income for the Wealthy, Middle, and Poor

Discussions about retirement income are unfocused because they blur distinctions between the wealthy and the poor, and between the stable-middle and the precarious-middle. The steady-middle earn adequate incomes throughout their working years and save enough for adequate retirement income. The precarious-middle consists of two groups. Low-earners strive to save from low earnings during their working years, but their meager savings place them precariously close to poverty. High-spenders spend their adequate incomes during their working years, failing to save enough for adequate retirement income. Retirement-income deficiencies are most acute among the precarious-middle and the poor. Mandatory retirement savings plans benefit the precarious-middle by replacing weak self-control with strong outside control, but mandatory retirement savings plans offer little benefit to the poor, who have little from which to save. Help for the poor calls for measures beyond making retirement savings plans mandatory.
Distributed camera network localization

Localization, estimating the positions and orientations of a set of cameras, is a critical first step in camera-based sensor network applications such as geometric estimation, scene reconstruction, and motion tracking. We propose a new distributed localization algorithm for networks of cameras with sparse overlapping view structure that is energy efficient and copes well with networking dynamics. The distributed nature of the localization computations can result in order-of-magnitude savings in communication energy over centralized approaches.
A Survey of Primate Populations in Northeastern Venezuelan Guayana

The region of the Guiana Shield is extraordinarily rich in biodiversity. Little is known, however, of the biogeography and conservation status of its diverse primate taxa. The aim of this study was to conduct a rapid survey of primate populations in the northeastern-most part of the state of Bolivar, Venezuela, near the border with Guyana. A previous study had indicated that the white-faced saki (Pithecia pithecia the white-faced saki (Pithecia pithecia the white-faced saki ( ), wedge-capped capuchin (Cebus olivaceus), and red howler monkey (Alouatta seniculus ), and red howler monkey (Alouatta seniculus ), and red howler monkey ( ) were present in this area. It had also been suggested that black spider monkeys (Ateles paniscus were present in this area. It had also been suggested that black spider monkeys (Ateles paniscus were present in this area. It had also been suggested that black spider monkeys ( ), golden-handed tamarins (Sagui- nus midas), and night monkeys (Aotus ), and night monkeys (Aotus ), and night monkeys ( ) may be present in this part of the Venezuelan Guayana. Forty-nine sites of the Rio Cuyuni basin were surveyed. Pre-existing forest trails were walked and the Rio Cuyuni was also censused by boat. Interviews with local people at all the sites indicated that the only primates inhabiting this region are A. seniculus, C. olivaceus, and P. pithecia. S. midas and P. pithecia. S. midas and is not present (or is extremely rare) in the northeastern part of the state of Bolivar. References to night monkeys may well refer to Potos fl avus. The presence of an isolated population of Ateles remains uncertain. Cattle ranching, mining, hunting, logging, and the pet trade are major threats to the primates in this part of Venezuela. Further primate surveys should be conducted in the western Guiana Shield. Resumen: El macizo de las Guayanas representa una de las regiones de mayor biodiversidad en el Neotropico. Sin embargo, aun es poco conocido la biogeografia y estado de conservacion de sus diversas especies de primates. Por tal motivo, el principal objetivo de esta investigacion fue conducir un reconocimiento de poblaciones de primates en la parte mas noreste del estado Bolivar (Venezuela), cerca del borde internacional con Guyana. Un estudio previo indico que monos viudita (Pithecia pithecia Bolivar (Venezuela), cerca del borde internacional con Guyana. Un estudio previo indico que monos viudita (Pithecia pithecia Bolivar (Venezuela), cerca del borde internacional con Guyana. Un estudio previo indico que monos viudita ( ), monos capuchinos comunes (Cebus olivaceus), y araguatos (Alouatta seniculus
Strategic Network Planning

In this chapter we will focus on the long-term, strategic planning and design of the supply chain. During the strategic planning, an organization attempts to design a supply chain which will enable this organization to maximize its economic performance over an extended period of time. Together with product research and development and marketing, the supply chain is one of the essential tools for a company to achieve their strategic business goals and practices. During the strategic planning process, companies identify their key products, customer markets for these products, core manufacturing processes and suppliers of raw and intermediate materials. Virtually all organizations must redesign their supply chain from time to time to respond to changing market conditions, but the recent wave of mergers and acquisitions and the globalization of the economy have made this process even more frequent and important. For example, a company may wish to expand into a new geographical area where no infrastructure is currently in place, such as the expansion by electronics manufacturing companies into Eastern Europe after those countries adopted a market economy. Another company may wish to consolidate the duplicate distribution systems created by a merger or acquisition. Finally, strategic planning is not only used for expansion, but also for retraction, such as when the United States Armed Forces developed a strategic plan for the base closings associated with the withdrawal from Western Europe.
LONG-TERM SAFETY OF CONCOMITANT USE OF PROTON PUMP INHIBITORS AND H2 RECEPTOR BLOCKERS WITH THIENOPYRIDINES IN THE SETTING OF CORONARY STENTING

Despite divergent findings, current evidence suggests that concomitant proton pump inhibitor (PPI) use in patients on thienopyridines after stenting leads to increased rates of recurrent ACS. Little is known about the safety and efficacy of other anti-acid medications such as H2 receptor blockers (
Extending Java for package based access control

This paper describes an extension of the Java language that provides programmable security. The approach augments the Java syntax with constructs for specifying various access control policies for Java packages, including DAC, MAC, RBAC and TBAC. A primitive ticket based mechanism serves as the foundation for programmable security. The implementation incorporates a preprocessor for language translation and a security service library that implements the ticket management infrastructure. The preprocessor translates the extended Java source code to native Java for eventual bytecode interpretation simultaneously binding security services to the native code. The design is simple and flexible and provides developers with an effective tool for programming security within Java packages.
Performance Analysis of Optical Flow Switching

In our previous work [1], [2], we presented Optical Flow Switching (OFS) as a key enabler of scalable future optical networks. In the present work, we propose a practical scheduling algorithm and conduct an approximate throughput-delay analysis for OFS networks.
Euglycemic Diabetic Ketoacidosis with Acute Pancreatitis in a Patient Not Known to Have Diabetes

ABSTRACT Objective: Euglycemic diabetic ketoacidosis (DKA) is a less known presentation of DKA. The aim of this case report is to alert physicians to the possibility of euglycemic DKA in a female patient presenting with metabolic ketoacidosis and to highlight the complex physiologic interplay between severe alcohol-related pancreatic injury, ketoacidosis, and starvation. Methods: We describe a patient with a known history of alcoholism who presented with metabolic acidosis and acute pancreatitis and was not known to have diabetes. Results: Computed tomography (CT) of the abdomen showed severe pancreatitis. The patient had not eaten for over 1 week. Laboratory work-up showed severe metabolic acidosis and no alcohol. Her acidosis improved only after euglycemic DKA was suspected; intravenous (IV) insulin infusion and dextrose were initiated, and her fluid/electrolyte abnormalities and carbohydrate metabolism were normalized. Conclusion: Euglycemic DKA occurs in a small subset of patients with DKA and can go undiagnosed at initial presentation. It is thought to be due to starvation and food restriction, which inhibits gluconeogenesis, and is mainly observed in patients with a history of diabetes and insulin deficiency. Abbreviations: AKA alcoholic ketoacidosis DKA diabetic ketoacidosis HbA1c glycated hemoglobin A1c IV intravenous
Inequitable conduct and patent misuse

Most conceptions of the patent law envision a system of rules that seek to balance private rights against public interests that include promoting innovation, removing impediments to competition, and making new and useful information broadly available. Here, we review recent insights into two patent doctrines that are deeply infused with this tension: inequitable conduct and patent misuse.
Receiving Support, Giving Support, Neighborhood Conditions, and Waist/Hip Ratios.

Obesity is a major health problem in the USA, and as a result, it is important to identify the factors that help people keep their body weight within healthy limits. The purpose of this study was to see whether receiving support at church and giving support at church buffer (i.e., moderate) the effects of living in rundown neighborhoods on a key marker of obesity-waist/hip ratios (WHR). The data are provided from a recent nationwide survey of people age 18 and older (N = 1456). The findings reveal that giving support to fellow church members tends to offset the effects of living in dilapidated neighborhoods on WHR. In contrast, receiving support from coreligionists does not appear to perform a similar stress-moderating function. The theoretical underpinnings of providing support at church are discussed.
Identifying Smartphone Based Intelligent Messages for Worker’s Crossing in Work Zones

A smartphone warning system is a feasible option to notify motorists about a safety threat and/or pedestrian crossings ahead. In this paper, a smartphone-based warning system was proposed to enhance workers’ safety in work zones. Three different warning message systems, including sound, male voice and female voice, were designed to alert drivers. Twenty-four subjects were recruited for a total of ninety-six rounds driving simulator test in a work zone to investigate the impacts of smartphone-based warning messages on subjects’ driving performance, in terms of driving speed, speed variation, acceleration, and brake reaction distance. The outcome showed that, with the assistance of the sound and voice (either female or male) warning messages, drivers could effectively reduce their accelerations and speeds. Meanwhile, such a warning system can induce subjects to shorten their brake reaction distances for worker crossings. All participants found that this warning system is applicable to enhance their defensive driving behaviors while driving through a work zone.
Finding Fulfilment through Self, Purpose and Community

I am currently in a period of transition. I am uprooting my life and moving to a new state, a new university, where I have landed a tenure-track position. Since I completed the doctorate four years ago, I have held positions as an Assistant Professor in-Residence and adjunct faculty teaching various courses ranging from Spanish language to theatre, core courses in English, and moving from small intimate classes of six students to large lectures of two hundred.
Tyrosine hydroxylase activity in the median eminence area of the pseudopregnant rat during surges of prolactin secretion.

AbstractSerum prolactin and LH levels were measured at several times during pseudo-pregnancy (PP) in the rat and compared to levels found in rats during diestrous Day 2. In the same rats, tyrosine hydroxylase (TH) activity and dopamine-β-hydroxylase (DBH) activity were measured in the median eminence area as indices of dopaminergic and noradrenergic neuronal activity, respectively. Serum LH and median eminence DBH were unchanged throughout the experiment. Serum prolactin was elevated at 1800 hr on Days 4 and 8 of PP and at 0100 hr on Days 5 and 9 compared to unstimulated controls. During the intersurge time (2200 hr) prolactin levels were low but slightly higher than controls. Tyrosine hydroxylase activity in the median eminence was low during the diurnal and nocturnal prolactin surges compared to unstimulated controls. It is concluded that the acute increases in prolactin levels in the blood that occur twice daily during PP may be related to the decrease in activity in dopamine containing neurons that oc...
Green pedagogy: How STEM teachers understand and enact environmental projects

In this thesis, I argue that to engage better the interest of policymakers, funders, and teachers, environmental educators and researchers need a deeper understanding of the STEM education movement...
The Application of New Highly Effective Medical Atomizer with Closed Tracheal Suction Catheter in Neonatal Intensive Care Unit

Objective:To compare the application of the new highly effective medical atomizer with closed tracheal suction catheter and the regular medical atomizer with closed tracheal suction catheter in Neonatal Intensive Care Unit.Methods:60 infants with mechanism ventilator were randomly divided into two groups,the intervention group (n1=30) and the control group (n2=30).The new highly effective medical atomizer with closed tracheal suction catheter was applied in the intervention group,while the regular medical atomizer with closed tracheal suction catheter was used in the control group.The moistering effects,the change in arterial blood gas analysis results,sputamentum stickiness,and the complications rate were compared between the two groups.Results:The evaluation indicators of the moistering effects,the change in arterial blood gas analysis results,sputamentum stickiness,and the complications rate in intervention group were better than that of the control group (all p0.05).Conclusion:The effect of the new highly effective medical atomizer with closed tracheal suction catheter was good on the infants with mechanism ventilator,which could be widely used in Neonatal Intensive Care Unit.
Analysis on the characteristics and revision of reported non-type viral hepatitis in Tianjin(2004-2013)

Objective To analyze the characteristics of the revision of reported and non-type viral hepatitis during the year 2004-2013 in Tianjin,and understand the effect of the management measures. Methods Download all primary reported non-type viral hepatitis cases data from the National Notifiable Disease Reporting System( NNDRS) from 2004 to 2013,and analyze the reported and revised cases distribution by description method. Results The non-type viral hepatitis incidence,non-type,diagnosis revised rate all declined from 2004 to 2013; delete-card rate and tel-fill rate both showed an increasing trend. Conclusion The viral hepatitis typing diagnosis and report quality have been improving in recent years in Tianjin,and reached a higher level.
Study on Customer Interpersonal Skills, Normative Participation and Customer Performance in Service Situation

The effect of customer’s interpersonal skills on customer normative participation and customer performance (including customer satisfaction and positive behavior post purchase) was investigated by the method of demonstration, and the complicated relationships between these variables based on structural equation model were discussed. The results show that the customer’s interpersonal skills have significantly positive effect on customer normative participation, satisfaction and positive behavior post purchase, and reveal the influence of the customer interpersonal skills on his behavior decision and the finally service evaluation during the service process. The results also provide a comprehensive understanding of the antecedent variables impacting on consumer performance and normative participation.
A microchip platform for structural oncology applications

Recent advances in the development of functional materials offer new tools to dissect human health and disease mechanisms. The use of tunable surfaces is especially appealing as substrates can be tailored to fit applications involving specific cell types or tissues. Here we use tunable materials to facilitate the three-dimensional (3D) analysis of BRCA1 gene regulatory complexes derived from human cancer cells. We employed a recently developed microchip platform to isolate BRCA1 protein assemblies natively formed in breast cancer cells with and without BRCA1 mutations. The captured assemblies proved amenable to cryo-electron microscopy (EM) imaging and downstream computational analysis. Resulting 3D structures reveal the manner in which wild-type BRCA1 engages the RNA polymerase II (RNAP II) core complex that contained K63-linked ubiquitin moieties-a putative signal for DNA repair. Importantly, we also determined that molecular assemblies harboring the BRCA15382insC mutation exhibited altered protein interactions and ubiquitination patterns compared to wild-type complexes. Overall, our analyses proved optimal for developing new structural oncology applications involving patient-derived cancer cells, while expanding our knowledge of BRCA1's role in gene regulatory events.
FLEXIBLE, WIRELESS, INDUCTIVELY COUPLED SURFACE COIL RESONATOR FOR EPR TOOTH DOSIMETRY

Managing radiation injuries following a catastrophic event where large numbers of people may have been exposed to life-threatening doses of ionizing radiation relies on the availability of biodosimetry to assess whether individuals need to be triaged for care. Electron Paramagnetic Resonance (EPR) tooth dosimetry is a viable method to accurately estimate the amount of ionizing radiation to which an individual has been exposed. In the intended measurement conditions and scenario, it is essential that the measurement process be fast, straightforward and provides meaningful and accurate dose estimations for individuals in the expected measurement conditions. The sensing component of a conventional L-band EPR spectrometer used for tooth dosimetry typically consists of a surface coil resonator that is rigidly, physically attached to the coupler. This design can result in cumbersome operation, limitations in teeth geometries that may be measured and hinder the overall utility of the dosimeter. A novel surface coil resonator has been developed for the currently existing L-band (1.15 GHz) EPR tooth dosimeter for the intended use as a point of care device by minimally trained operators. This resonator development provides further utility to the dosimeter, and increases the usability of the dosimeter by non-expert operators in the intended use scenario.
Abstract 2261: PKR and Jagged1 associated with lymph node metastasis in lung cancer

In the current study, we analyzed the association between lymph node metastasis and over 50 biomarkers in 319 NSCLC patients. We observed that tumor location and the protein expressions of Jagged1 and RNA-dependent protein kinase (PKR) have significantly association with the lymph node metastasis. We further investigated the mechanism of interaction between Jagged1 and PKR, and demonstrated that induction of PKR promotes Jagged1 protein degradation through proteasome system in lung cancer cells. We also found that combination of Jagged1 with PKR improved prognostic value in all stages NSCLC patients. However, combination of Jagged1 with PKR did not improve lymph node metastatic value. Taken together, our data suggest that PKR and Jagged1 are independent markers for predicting lymph node metastasis, and PKR may reduce lymph node metastasis partly by promote Jagged1 proteins degradation in NSCLC patients. Citation Format: Apar Pataer, Chuncheng Hao, Arlene M. Correa, Annikka Weissferdt, Carmen Behrens, Ignacio I. Wistuba, Stephen G. Swisher. PKR and Jagged1 associated with lymph node metastasis in lung cancer. [abstract]. In: Proceedings of the 107th Annual Meeting of the American Association for Cancer Research; 2016 Apr 16-20; New Orleans, LA. Philadelphia (PA): AACR; Cancer Res 2016;76(14 Suppl):Abstract nr 2261.
Multidimensional Democracy: A Supply and Demand Theory of Representation

Crisanta Duran represents Colorado House District 5, which encompasses northwest and central Denver. Her constituency is quite diverse in several respects, including considerable variation in income and race. Her goal as a legislator is to maximize communication with the public and “bring people into the political process.” Because of the many different perspectives in her district, she does that in many different ways. Areas included in Rep. Duran's district range from the Sun Valley neighborhood, where 72 percent of the residents live in poverty, to downtown Denver, where many live in expensive high-rise condos. She says that the expectations that constituents from these areas have of her are often very different. For example, in response to demand from her downtown constituents, she has worked to extend tax credits for electric and fuel-efficient vehicles and to require homeowners’ associations to provide electric car charging stations. Among other things, constituents in the low-income neighborhoods of her district contact her for help with foreclosures or environmental problems that arise from nearby commercial and industrial areas. Rep. Duran's website, which is available in both English and Spanish, reflects her responsiveness to this diverse group of constituents. Items on the site include details on her efforts to encourage access to renewable energy as well as $4 million in funding she worked to secure for renovation to the Auraria Campus Library. She also discusses efforts ranging from balancing the state budget to supporting driver's licenses for all Coloradans, including undocumented persons. In short, the job is not “one size fits all” for Rep. Duran. Instead, responding to her diverse constituency requires her to focus on several different dimensions of representation at once. The democratic process implies that citizens should be able to get what they want from government by electing who they want. This is sometimes – though not always – the case with policy issues; research shows that there are electoral consequences for being out-of-step (Canes-Wrone et al., 2002; Hogan, 2008; Birkhead, 2015). However, representation in practice is based on more than just policy. Constituents’ preferences may be more complex, with some interested in representation through other means besides just policy. Similarly, legislators may choose to focus on those other means of providing representation. In this chapter, I develop a theoretical framework for conceptualizing the dimensions of representation as commodities that are both demanded by constituents and, in response, supplied by legislators.
Glycemic control: Can nurse practitioners on interprofessional collaborative practice teams enhance clinical outcomes?

Background and purpose Care coordination and specialized knowledge of prescriptive authority are fundamental to advanced nursing practice. Little research documents patient clinical outcomes in primary care when nurse practitioners are members of an interprofessional education and collaborative practice (IPECP) team. This cross-sectional study examined differences in glycemic control among Texas patients who received care by a Family Nurse Practitioner (FNP) and an IPECP team in one calendar year. Methods A convenience sample of 120 adult volunteers with diabetes was followed in a community-based clinic by an FNP; of these, 34 received additional care by an IPECP team. Data on selected demographic indices and HgbA1c were derived from the health center's Electronic Medical Record using a retrospective review, and linkage with the federally funded IPECP Project database. Conclusions Patients with two or more FNP visits and two or more visits with the IPECP team had statistically significant reductions in HgbA1c levels at the end of 1 year. Implications for practice Actualizing point-of-care treatment adjustments is a particular strength of advanced practice nurses but potentially a missed opportunity on interprofessional teams. Further study is needed on clinical outcomes of nurse practitioner contributions to IPECP team care.
Clovis Caches: Recent Discoveries and New Research

I really like the edited volume Clovis Caches, and I am certain that anyone with an interest in hunter-gatherer lithic technology or Paleoindian archaeology will be happy to have a copy on the shel...
Lateral Browlift Using Temporal (Pretrichial) Subcutaneous Approach Under Local Anesthesia

Lateral brow ptosis is a common aging phenomenon, contributing to the lateral upper eyelid hooding, in addition to dermatochalasis. Lateral brow lift complements upper blepharoplasty in achieving a youthful periorbital appearance. In this study, the author reports his experience in utilizing a temporal (pretrichial) subcutaneous lateral brow lift technique under local anesthesia. A retrospective analysis of all patients undergoing the proposed technique by one surgeon from 2009 to 2016 was conducted. Additional procedures were recorded. Preoperative and postoperative photographs at the longest follow-up visit were used for analysis. Operation was performed under local anesthesia. The surgical technique included a temporal (pretrichial) incision with subcutaneous dissection toward the lateral brow, with superolateral lift and closure. Total of 45 patients (44 females, 1 male; mean age: 58 years) underwent the temporal (pretrichial) subcutaneous lateral brow lift technique under local anesthesia in office s...
Evaluation of (Dream Herb,) Calea zacatechichi, for Nephrotoxicity Using Human Kidney Proximal Tubule Cells

A recent surge in the use of dietary supplements, including herbal remedies, necessitates investigations into their safety profiles. “Dream herb,” Calea zacatechichi, has long been used in traditional folk medicine for a variety of purposes and is currently being marketed in the US for medicinal purposes, including diabetes treatment. Despite the inherent vulnerability of the renal system to xenobiotic toxicity, there is a lack of safety studies on the nephrotoxic potential of this herb. Additionally, the high frequency of diabetes-associated kidney disease makes safety screening of C. zacatechichi for safety especially important. We exposed human proximal tubule HK-2 cells to increasing doses of this herb alongside known toxicant and protectant control compounds to examine potential toxicity effects of C. zacatechichi relative to control compounds. We evaluated both cellular and mitochondrial functional changes related to toxicity of this dietary supplement and found that even at low doses evidence of cellular toxicity was significant. Moreover, these findings correlated with significantly elevated levels of nephrotoxicity biomarkers, lending further support for the need to further scrutinize the safety of this herbal dietary supplement.
Development of electron beam recorder with a /spl theta/-stage

In this paper, outline of EBR and the results of circle patterning were reported. Electron beam recorder with the /spl theta/-stage had a promising ability for high accuracy recording.
The viral protein gp120 decreases the acetylation of neuronal tubulin: potential mechanism of neurotoxicity.

The human immunodeficiency virus (HIV) envelope protein gp120 promotes axonal damage and neurite pruning, similar to that observed in HIV-positive subjects with neurocognitive disorders. Thus, gp120 has been used to examine molecular and cellular pathways underlying HIV-mediated neuronal dysfunction. Gp120 binds to tubulin beta III, a component of neuronal microtubules. Microtubule function, which modulates the homeostasis of neurons, is regulated by polymerization and post-translational modifications. Based on these considerations, we tested the hypothesis that gp120 induces dynamic instability of neuronal microtubules. We first observed that gp120 prevents the normal polymerization of tubulin in vitro. We then tested whether gp120 alters the post-translational modifications in tubulin by examining the ability of gp120 to change the levels of acetylated tubulin in primary rat neuronal cultures. Gp120 elicited a time-dependent decrease in tubulin acetylation that was reversed by Helix-A peptide, a compound that competitively displaces the binding of gp120 to neuronal microtubules. To determine whether post-translational modifications in tubulin also occur in vivo, we measured acetylated tubulin in the cerebral cortex of HIV transgenic rats (HIV-tg). We observed a decrease in tubulin acetylation in 5- and 9-month-old HIV-tg rats when compared to age-matched wild type. Neither changes in microglia morphology nor alterations in mRNA levels for interleukin-1β and tumor necrosis factor α were detected in 5-month-old animals. Our findings propose neuronal microtubule instability as a novel mechanism of HIV neurotoxicity, without evidence of enhanced inflammation.
Future challenges for commercial vehicle development

When the commercial vehicle market is analyzed from a global perspective, it becomes obvious, that the requirements are significant divers in the various regions.
Combustion-related organic species in temporally resolved urban airborne particulate matter

Accurate characterization of the chemical composition of particulate matter (PM) is essential for improved understanding of source attribution and resultant health impacts. To explore this we conducted ambient monitoring of a suite of 15 combustion-related organic species in temporally resolved PM 2.5 samples during an ongoing animal exposure study in a near source environment in Detroit, MI. All of the 15 species detected were above the method detection limit in 8 hour samples. This study focused on two molecular classes: Polycyclic Aromatic Hydrocarbons (PAHs) and Hopanes measured in samples. Of the 12 PAHs studied, benzo[b]fluoranthene (169 pg m-3), benzo[g,h,i]perylene (124 pg m-3), and benzo[e]pyrene (118, pg m-3) exhibited the three highest mean concentrations while 17α(H),21β(H)-Hopane (189 pg m-3) and 17α(H),21β(H)-30-Norhopane (145 pg m-3) had the highest mean concentrations of the 3 Hopanes analyzed in samples. Ratios of individual compound concentrations to total compound concentrations (∑ 15 compounds) showed the greatest daily variation for 17α(H),21β(H)-Hopane (11-28%) and 17α(H),21β(H)-30-Norhopane (8-20%). Diagnostic PAH concentration ratios ([IP]/[IP + BP] (range 0.30 - 0.45), [BaP]/[BaP+BeP] (range 0.26 - 0.44), [BaP]/[BP] (range 0.41 - 0.82), [Bb]/[Bk] (range 2.07 - 2.66), in samples reflected impacts froma mixture of combustion sources consistent with greater prevalence of petroleum combustion source emissions (gasoline, diesel, kerosene, and crude oil) compared to coal or wood combustion emissions impacts at this urban site. Results from this study demonstrate that short duration sampling for organic speciation provides temporally relevant exposure information.
COACH: Cognitive analytics for change

This paper presents our initial efforts towards building a cognitive analytics framework for change management. We propose a novel predictive algorithm for change risk calculation based on historical change failures, server failures, change triggered incidents as well as expert user input. Our predictive algorithm provides significant improvement over traditional risk assessments in proactively capturing problematic changes when tested with real client account data.