cssi/SciSciGPT-SciSciNet huggingface dataset:
Thromboxane A2 and peptidoleukotrienes contribute to the myocardial ischemia and contractile dysfunction in response to intracoronary infusion of complement C5a in pigs.

Intracoronary infusions of activated complement C5a result in myocardial ischemia, contractile dysfunction, and leukocyte accumulation. The hypothesis was tested that the generation of the coronary vasoconstrictors, thromboxane A2 and the 5-lipoxygenase leukotrienes (LTC4 and LTD4), contributes to the C5a-induced decrease in coronary blood flow and contractile function. The left anterior descending coronary artery in anesthetized swine was cannulated and servo pump-perfused with arterial blood at constant pressure and measured flow. Regional subendocardial contractile function was assessed with sonomicrometry. The interventricular vein was cannulated for sampling of coronary venous blood for leukocyte count. The responses in left anterior descending coronary artery blood flow and percent segment shortening to intracoronary infusions of LTC4 (1 microgram), LTD4 (1 microgram), thromboxane agonist U46619 (7.5 micrograms), and C5a (500 ng) were assessed before and after 1) LTD4/LTE4 receptor blockade with leukotriene receptor blocker LY171883 (10 mg/kg i.v.) (n = 5), 2) thromboxane A2/prostaglandin H2 receptor blockade with thromboxane receptor blocker BM13505 (2 mg/kg i.v.) (n = 5), and 3) combined thromboxane and leukotriene receptor blockade (n = 5). In the absence of receptor blockade, intracoronary C5a decreased coronary flow (50-60%) and regional segment function (60-70%) compared with the preinfusion levels. This was accompanied by a fall in coronary venous blood leukocyte levels by 5-6 x 10(6) cells/ml in the absence of alterations in arterial blood leukocyte count. Intracoronary injections of LTD4, LTC4, or U46619 also resulted in prompt decreases in coronary blood flow (50-60%) and segment function (70-80%) from preinfusion levels. Leukotriene receptor blockade with LY171883 abolished these responses to LTD4 and LTC4. Administration of LY171883 also attenuated (p less than 0.05) the myocardial response to C5a; coronary flow and segment function decreased by approximately 28% from preinfusion levels. Thromboxane receptor blockade with BM13505 eliminated the response in coronary flow and segment function to intracoronary U46619. Similar to LY171883, administration of BM13505 blunted (p less than 0.05) the C5a-induced decreases in coronary flow and contractile function, which fell by approximately 20-25% from the preinfusion level. After the combined LTD4/LTE4 receptor and thromboxane A2/prostaglandin H2 receptor blockade, intracoronary C5a resulted in little change in both coronary blood flow and segment shortening. In contrast to the flow and function effects, the C5a-induced myocardial leukocyte extraction was not decreased by leukotriene and/or thromboxane receptor blockade.(ABSTRACT TRUNCATED AT 400 WORDS)
Effects of Loss Characteristics on Loss-Recovery Techniques for VoIP

Voice over Internet Protocol (VoIP) is a technology that transports voice data packets across packetswitched networks using the Internet Protocol (IP). Losing packets in the network is inevitable, and losing voice packets degrades audio quality. There are many loss-recovery techniques that designers can use to mitigate the undesired effects of packet loss. Some of these loss-recovery techniques use senderbased procedures, and others use receiver-based procedures. We examine several well-known sender-based loss-recovery techniques that are feasible for realtime interactive VoIP applications. We analyze the bandwidth requirements, buffering delays, and perceptual sound qualities of these techniques. We report the effects that various types of loss conditions have on the effectiveness of these approaches in improving the Quality of Service (QoS) of VoIP.
On the Formation and Decay of Rotor Blade Tip Vortices

Models for the rate of decay of rotor tip vortices, based on near-wake data and computations, are in conflict with the observed persistence of rotor tip vortices for many revolutions. A correlation of data from the literature shows that the measured tip vortex strength is only 40% of the strength expected from the peak of the blade bound circulation, for blades with sharply-cut straight-edged tips, over a wide range of tip Mach and Reynolds numbers. Explanations of this drop in the near wake through turbulence models, are seen to be both counter-intuitive and in conflict with measurements of turbulent fluctuations. Using flow visualization and velocimetry in the wake of a 2-bladed rotor in low-speed forward flight, explanations are shown for these mysteries. Shear layer development at the blade tip, and the twist distribution of the blade have a strong influence on the fraction of the blade tip vorticity lost into the inboard counter-rotating wake. The observations of elliptic core shape and of multiple local extrema of axial velocity deficit, are shown to be features of the shear-layer separation and rollup processes. Blade-to-blade differences in vortex evolution from the same rotor are traced to surface texture differences at the blade tip. Results in the literature reporting 90 t0 100% tip circulation recovery for such blades, are seen to be in cases where the induced velocity due to the tip vortex could not be distinguished from that due to the inboard sheet.
CASE STUDY: Assessment of Relationships Between Carcass Traits and Body Measures at Conclusion of Pasture Backgrounding1

Direct measures of body size and condition may be useful in sorting feeder cattle into uniform groups prior to entering the feedlot. Two groups of yearling steers were allocated to three pastures during either the cool or warm seasons and placed on low, intermediate, or high planes of nutrition with a corn-soybean meal supplement. Hip height (HIPH), BW, ultrasound fat thickness (12th to 13th rib; UFT), kilograms of BW per centimeter of HIPH (BW/HIPH), body condition score (BCS), and UFT/100 kg of BW (UFT/BW) were taken at the end of stocker grazing and compared with endpoint carcass traits. Correlations
Frank H. Mayfield, MD, FACS, FAANS (1909–1991): 75th Anniversary Tribute

In this special issue, coinciding with Mayfield Clinic’s 75th anniversary, we recognize the vision and practical wisdom of Dr. Frank H. Mayfield, who inspired solutions to the devastating problems of cerebral vasospasm after subarachnoid hemorrhage (SAH). This conference proceedings, Vasospasm 2011: 11th International Conference on Neurovascular Events after SAH, is dedicated to Dr. Mayfield, a University of Cincinnati professor and pioneer in neurosurgery who directed the graduate neurosurgical training programs at The Christ Hospital and Good Samaritan Hospital from 1946 to 1977. His lasting, distinguished contributions in aneurysm surgery formed, in part, some of the foundational science for this conference’s nearly 200 cerebrovascular experts from 20 nations who are taking important steps toward developing the first optimal clinical management strategy for vasospasm.
Development of An Immobilized Enzyme Electrode for the Determination of Sulfite Ion

An enzyme electrode was developed using the enzyme sulfite oxidase (EC1.8.3.1) immobilized onto pig intestine. Hydrogen peroxide produced was monitored amperometrically. All experimental parameters such as pH, temperature, buffer constituent concentration, were thoroughly investigated and optimized when appropriate. The response to sulfite concentration was linear in the range 5.2´10-6 to 1.02´10-3 M. The proposed method was found to have a correlation coefficient of 0.952 when evaluated in comparison with the standard titration method.
Enzymatic Synthesis of High sn-2 DHA and ARA Modified Oils for the Formulation of Infant Formula Fat Analogues

High sn-2 docosahexaenoic and arachidonic acid oils (DHAOm and ARAOm, respectively) were produced independently via enzymatic interesterification of DHA-rich and ARA-rich single cell oils (DHASCO and ARASCO, respectively) using a mix of immobilized lipases, Lipozyme® TL IM and Novozym® 435 (weight ratio 1:1) as the biocatalyst system. Response surface methodology (RSM) was employed to model and optimize the reactions conditions. Three independent variables, namely reaction time, reaction temperature, and enzyme load, were investigated in DHAOm and ARAOm models. The prediction power of the model was further confirmed by solvent-free scale-up reactions of 100 g per batch. Final results showed that DHAOm contained 46.53 mol% of total DHA (49.70 % at the sn-2 position), while ARAOm contained 47.25 mol% of total ARA (36.08 % at the sn-2 position). This represents a significant increment in the amount of DHA and ARA at the sn-2 position when compared to DHASCO (47.8 mol%; 30.30 % at the sn-2) and ARASCO (47.79 mol%; 28.50 % at the sn-2), respectively. These products have potential as additions to infant formulas where DHA and ARA supplementation is required.
Teaching Methods and Assessment Techniques for the Undergraduate Introductory Finance Course: A National Survey

This paper reports the results of a national survey of corporate finance faculty teaching methods and assessment techniques. Of the 852 surveys sent out, 170 were returned. The survey results indicate that lectures and instructor-led problem solving are the dominant teaching methods. Textbook reading and individual homework are the primary outside-class assignments. Students' overall grades are determined almost entirely by individual in-class exams. Most finance faculty use computers in their teaching. Approximately half of finance faculty use group work and writing assignments, but fewer than half use student presentations in their courses.
Complete Genome Sequence of Klebsiella pneumoniae Carbapenemase-Producing K. pneumoniae Siphophage Sushi.

ABSTRACT Klebsiella pneumoniae is a Gram-negative pathogen frequently associated with antibiotic-resistant nosocomial infections. Bacteriophage therapy against K. pneumoniae may be possible to combat these infections. The following describes the complete genome sequence and key features of the pseudo-T-even K. pneumoniae carbapenemase (KPC)-producing K. pneumoniae myophage Miro.
A strain of unclassified cells isolated from lymph node of patient with reticulo-endotheliosis.

SummaryA strain of human cells isolated from the lymph node of a patient under treatment with ACTH with the clinical and pathologic diagnosis of “reticulo-endotheliosis”is reported. This cell line ...
Erythropoietic action of a plasma filtrate in hypophysectomized rats.

SummaryA filtrate of boiled plasma obtained from rabbits rendered severely anemic by phenylhydrazine was administered daily for 10 days to hypophysectomized rats. Significant increases occurred in peripheral red cell; hemoglobin, hematocrit and reticulocyte values. The bone marrows of these animals showed signs of intense erythroid cell hyperplasia.
Reliability Analysis of Non-series Manufacturing Systems Based on Petri Nets

Through in-depth study on the reliability of non-series manufacturing systems with buffers,the reliability model based on generalized stochastic Petri nets is built.The occurring of assembly and disassembly,the working procedures with assembly or disassembly carried out per different proportions,and the influence of buffer availability on the machine availability are considered emphatically.On the basis of this model,the buffer availability theorem is adopted for classification and solution of the state transition probabilities of buffer and machine itself respectively,and the corresponding buffer availability and equivalent machine availability are calculated.Moreover,through the function reliability index,overall evaluation of the reliability of the whole manufacturing workshop is carried out.By starting from factors of time variable and production volume,the delay of processing time of related work pieces caused by the blocking of transmission path and stock shortage due to the unbalance of productivity and too small buffer inventory is measured.A manufacturing assembly cell with three machines and two work pieces is taken as an example to verify the effectiveness of the model and analysis method.
Availability of phosphorus in bone meal

Two commercially available bone meal products (grades 0-12-0 and 6-12-0) were examined. Samples were prepared according to AOAC method 2.007, and total and available phosphorus contents were determined. Portions of these preparations were reground to pass through successively smaller sieves, and subsequent analyses indicated the availability of phosphorus to be directly proportional to fineness of grind. A quantity of the citrate-insoluble fraction of the bone meal was obtained by following AOAC extraction procedures. Agronomic studies were conducted that compared this insoluble fraction with the original bone meal material and with reagent grade Ca(H2PO4)2.H2O. The data indicated poor correlation between the analytically defined and agronomically determined availability of phosphorus.
AN AMERICAN DEFINITION OF HISTORY: Turner

[The work of Frederick Jackson Turner (1861–1932) opened a new era in American historiography. Familiar with European and ancient history, and influenced by the German historians, especially A. H. L. Heeren, Turner nevertheless demanded that American history must be studied as an outgrowth of the distinct American experience, moulded more by the frontier of the West than the continuing link with the Old World. Having become dissatisfied with the traditional political historiography, he sought in his writings and his influential teaching to grasp the significance, to find the inner springs of this American experience. He taught first at the University of Wisconsin and in 1910 accepted a chair at Harvard. His essay on “The Significance of the Frontier in American History” appeared in 1893, and the Rise of the New West in 1906.
Cerebral Metabolism and the Role of Glucose Control in Acute Traumatic Brain Injury

This article reviews key concepts of cerebral glucose metabolism, neurologic outcomes in clinical trials, the biology of the neurovascular unit and its involvement in secondary brain injury after traumatic brain insults, and current scientific and clinical data that demonstrate a better understanding of the biology of metabolic dysfunction in the brain, a concept now known as cerebral metabolic energy crisis. The use of neuromonitoring techniques to better understand the pathophysiology of the metabolic crisis is reviewed and a model that summarizes the triphasic view of cerebral metabolic disturbance supported by existing scientific data is outlined. The evidence is summarized and a template for future research provided.
Mathematics on the Home Front.

children, about sights and sounds, and about other stimuli. They teach language to their offspring almost without conscious effort. They are teaching language when they talk to their infants, when they smile at them as they make their first sounds, and when they encourage, ever so patiently, those first words. It is no accident that a child's first word often is "ma" or "da." Parents are teaching reading and writing when they read to their children. These children learn to read for themselves more easily, and children who read well also write better than those who read less well. Reading and work on language at home have direct positive effects on reading and writing at school. One of the reasons parents often enjoy reading aloud with their children is that it generates good feelings. The parent and the child sit very close together, usually touching, in a big chair or on the child's bed among the pillows, and read a book. The atmo-
A History of Chinese Archaeology

The birth of modern Chinese archaeology in the early twentieth century was an outcome of the introduction of Western scientific methods, the rise of nationalism, and the search for the cultural origins of the nation. These three factors have had a continuing influence on the development of the discipline, with the consequence that archaeology in China has been firmly placed in the general field of history. Its research orientations and interpretations have been significantly affected by different political agendas of the nation—especially the ever-changing concept of nationalism in particular eras. In many cases, archaeology has been driven by the contemporary trend toward a more multiethnic concept of nationalism and used as an instrument to support, rather than to evaluate, particular theoretical themes or political agendas. In other situations, it has provided independent data for creating new paradigms, which changed traditional perspectives toward Chinese national history. This chapter reviews the developmental trajectory of Chinese archaeology, and discusses its contribution to our knowledge of Chinese history and prehistory.
Bidirectional influences of caregiver utterances and supported joint engagement in children with and without autism spectrum disorder.

This study examined sequential associations between pairs of caregiver talk and caregiver-child joint engagement categories. Sequential associations quantify the extent to which one event (such as a particular type of caregiver talk) follows another event (such as a particular type of joint engagement) in a pre-specified time window, while controlling for the chance occurrence of the sequence. Although unable to support strong conclusions about causality, the requirement of sequential analysis that key events occur within a close temporal sequence rules out alternative explanation for associations that summary-level correlations cannot. We applied sequential analysis to observational data on 98 caregiver-child dyads, fifty of which included a child with autism spectrum disorder (ASD). Groups were matched on mental age, and all were just beginning to develop spoken vocabulary. Sequential associations between supported joint engagement and caregiver follow-in utterances were stronger in ASD dyads as compared to dyads with typically developing children. Further, sequential associations between utterances related to the child's focus of attention followed by higher order supported joint engagement (HSJE) were stronger than between utterances that related to the caregiver's focus of attention and HSJE, across both groups. Finally, sequential associations between follow-in directives followed by HSJE were stronger than between follow-in comments followed by HSJE, again across both groups of children. Autism Res 2018, 11: 755-765. © 2018 International Society for Autism Research, Wiley Periodicals, Inc. LAY SUMMARY Our findings suggest that caregivers of children with autism spectrum disorder (ASD) may be particularly adept at timing their talk to follow moments of high-level joint engagement, and that follow-in directives are particularly facilitative of high-level joint engagement. Future intervention work can capitalize on these findings to support high level caregiver-child engagement around toys, which may promote development in children with ASD.
Multiscale Modeling of Asphaltic Pavements: Comparison with Field Performance and Parametric Analysis of Design Variables

AbstractThis study presents a multiscale model that concurrently links mixture-level component properties to the structural performance of asphaltic pavements. Two scales (the global scale of the p...
Critically Elevated Potassium in a 55-Year-Old Female With Chronic Lymphocytic Leukemia

Hyperkalemia in specimens from patients with chronic lymphocytic leukemia (CLL) may be due to tumor lysis syndrome (TLS) or specimen processing. This report describes a 55-year-old Caucasian woman with CLL who presented to an outside hospital with hyperkalemia and was transferred to a second hospital. Initial evaluation on the core laboratory chemistry analyzer (the VITROS 5600) and the ABL90 FLEX blood gas analyzer showed markedly elevated levels of potassium (K+). TLS was subsequently diagnosed, and dialysis was initiated. However, follow-up K+ measurements in whole blood (WB) yielded low levels that were unexpected after a single dialysis treatment. We then discovered that the initially elevated K+ level was from centrifuged plasma specimens and concluded that it indicated pseudohyperkalemia, likely from centrifugation. This case demonstrates that medical teams need be alert to potentially false K+ results in patients with elevated white blood cell counts. WB specimens are preferable, and steps to minimize trauma to the specimen and immediate analysis using blood gas instruments are recommended.
Cognitive Phenomenology in the Study of Tibetan Meditation: Phenomenological Descriptions Versus Meditation Styles

This chapter discusses the inclusion of phenomenological analysis in the cognitive psychological research of meditation. Different meditation styles involve the specific changes of the mind, such as a long-lasting, vivid, and stable mental imagery in some types of Tibetan meditation. Comparative phenomenological analysis of the Deity Yoga, mandala, Vipashyana, and Rig-pa types of Tibetan meditation was included in designing a cognitive experiment. Results indicate the increase of visual working memory due to the practice of Deity Yoga, suggesting access to the heightened visual processing resources (Kozhevnikov, Louchakova, Josipovic, & Motes. Psychological Science 20(5):645–653, 2009). The phenomenological part of the design, reported here for the first time, included a new methodology termed phenomenological-cognitive mapping (PCM). PCM linked the comparative phenomenological analysis of meditation to the psychological parameters of cognitive testing. PCM proved to be crucial in designing a successful experiment that led to novel findings. In the absence of PCM, isolating the meditation style that causes the optimization of visual-spatial processing and finding at what stage of meditation this happens would not be possible. This chapter argues in favor of including a detailed phenomenological analysis of experience in the cognitive research of meditation, as opposed to using only general classifications such as meditation styles.
Wada asymmetry in patients with drug-resistant mesial temporal lobe epilepsy: Implications for postoperative neuropsychological outcomes.

Objective This study reports neuropsychological outcomes based on preoperative Wada testing in patients with drug-resistant mesial temporal lobe epilepsy (mTLE). Methods Patient records were retrospectively reviewed as part of a larger database. Patients with a diagnosis of TLE based on seizure semiology and long-term surface video-electroencephalography (EEG) were identified. These patients underwent preoperative and postoperative testing including advanced imaging (magnetic resonance imaging [MRI]), Wada testing, and neuropsychological assessment. Decrements in neuropsychological function were noted in comparison of pre- and postoperative studies. Patients had regular follow-up in the multidisciplinary epilepsy clinic to assess seizure outcomes. All participants had Engel class I/II outcome following selective amygdalohippocampectomy (AH) via the inferior temporal gyrus (ITG) approach. Results Forty-eight patients with electrographic and clinical semiology consistent with unilateral mTLE were identified. Left mTLE was identified in 28 patients (58.3%), whereas 20 patients (41.7%) had right mTLE. Language-dominant hemisphere resections were performed on 23 patients (47.9%) (all left-sided surgery), whereas 25 (52.1%) had language nondominant resection (all right-sided and five left-sided surgery). Twenty-two participants (45.8%) showed no Wada memory asymmetry (No-WMA), whereas 26 (54.2%) exhibited Wada memory asymmetry (WMA). Postoperatively, analysis of variance (ANOVA) found that the No-WMA group exhibited a decline in verbal memory, but average scores on measures of nonverbal reasoning, general intelligence, and mood improved. Alternatively, patients with WMA did not show declines in memory postoperatively, and also exhibited improved nonverbal reasoning and general intelligence. Neither group exhibited reliable decline in verbal fluency or visual confrontation naming. Significance Wada procedures for predicting surgical outcome from elective temporal surgery have been criticized and remain an area of active debate. However, decades of data across multiple epilepsy centers have demonstrated the value of Wada for reducing unanticipated neuropsychological adverse effects of surgical treatment. These data show that no Wada memory asymmetry increases the risk for neuropsychological decline following ITG approach for selective AH for drug-resistant mTLE.
Health Disparities Educational Initiative for Residents.

Background: The Wayne State University Graduate Medical Education (GME) Office and Ascension Crittenton Hospital developed an educational initiative to increase resident awareness of health disparities and local community health priorities. The Plan-Do-Study-Act (PDSA) rapid-cycle performance improvement framework was used for implementation and evaluation. Methods: During the first PDSA cycle, residents attended 5 didactic sessions. During the second PDSA cycle, residents participated in a problem-based learning (PBL) case. The following data were collected: evaluations of the didactic sessions and case, the number of appointments for diabetes self-management and education (DSME) referred by faculty and residents, and responses to questions on the annual GME surveys related to resident understanding of health disparities and the hospital’s community health needs assessment (CHNA). Results: Eighty-eight percent of residents defined health disparities at least partially correctly in both project years. The percentage of residents who knew how to access their hospital’s CHNA increased from 25% to 29% year over year. Residents rated PBL more effective in achieving learning objectives than didactics, but the difference was not statistically significant. Six appointments for DSME were referred by program faculty and residents in the 2-month period immediately before the didactic sessions, and 6 referrals were made in a 2-month period between the didactic sessions and the PBL case. In the 2-month period immediately following the PBL case, 9 appointments for DSME were referred by residents and program faculty. Conclusion: Residents have a good understanding of health disparities, although many may not recognize disparities that exist in their local community. PBL was more effective than didactics for resident education about local health disparities, CHNA, and DSME. Aligning GME and hospital leadership in a common vision for disparities education, as well as community engagement, is critical to successful outcomes.
Numerical linked-cluster expansions for disordered lattice models

Imperfections in correlated materials can alter their ground state as well as finite-temperature properties in significant ways. Here, we develop a method based on numerical linked-cluster expansions for calculating exact finite-temperature properties of disordered lattice models directly in the thermodynamic limit. We show that a continuous distribution for disordered parameters can be achieved using a set of carefully chosen discrete modes in the distribution, which allows for the averaging of properties over all disorder realizations. We benchmark our results for thermodynamic properties of the square-lattice Ising and quantum Heisenberg models with bond disorder against Monte Carlo simulations and study them as the strength of disorder changes. We also apply the method to the disordered Heisenberg model on the frustrated checkerboard lattice, which is closely connected to ${\mathrm{Sr}}_{2}\mathrm{Cu}({\mathrm{Te}}_{0.5}{\mathrm{W}}_{0.5}){\mathrm{O}}_{6}$. Our method can be used to study finite-temperature properties of other disordered quantum lattice models, including those for interacting lattice fermions.
Automated Synthesis of Multi-Port Memories and Control

High performance systems often employ multi-ported memories to enhance the throughput and flexibility of the memory. Existing SRAM compilers offer limited control over the SRAM design and port configurations while SRAMs are commonly dual-ported. Experimental designs could benefit from design exploration of multi-port configurations. We propose an open-source, multi-port solution that extends the OpenRAM memory compiler. A parameterized bitcell is presented which can support any combination of read, write, and read-write ports. The bitcell layout is generated for these port combinations, and the SRAM layout can support any combination of two ports. In addition, support for multi-port characterization and functional testing ensures correctness and incorporation into design methodologies.
High Strength Inflatable Pouch Anchors

Anchoring is an important capability for mobile robots to conserve power, survey an area, or deploy a payload. However, the careful placement of an anchor in unstructured environments requires a great deal of dexterity, perception, and planning. Furthermore, many of the reversible adhesives that may be used for anchoring are surface-dependent. We introduce inflatable pouch anchors as a versatile, low-power, and easy-to-position technology for anchoring in natural surfaces. By using negative space such as gaps and cracks with a flexible pouch, the challenge of placing an anchor is greatly simplified. We used a compressed CO$_2$ canister to supply pressure, and a three-way normally-closed valve to allow for multiple uses. We tested the anchor with high friction interfaces such as microspines and gecko-inspired adhesives. We validated the performance with tests on smooth acrylic, sandpaper, manufactured rock, and natural rock. The 425 g anchor actuated at an internal pressure of 105 kPa held over 700 N when anchored in natural rock with a microspine interface.
Outflow Cannula Systolic Slope as a Predictor of Myocardial Recovery Leading to Successful LVAD Decommission: A Case Series

Purpose In patients implanted with durable left ventricular assist device (LVAD), the incidence of myocardial recovery leading to device explant or decommission is low, and reliable predictors of myocardial recovery remain lacking. Here, we investigate the potential of outflow cannula systolic slope as a non-invasive predictor of successful LVAD liberation amongst select cohort of patients with high recovery potential. Methods We first identified a cohort of patients with high recovery likelihood by querying all LVAD patients at our institution who underwent reverse ramp test, a protocol developed to assess native myocardial contractility with sequential LVAD turn-down to minimal support. We then queried all echocardiographic studies of these patients within one year of the reverse ramp tests. In the subset of patients with adequate Doppler images of the outflow cannula, the systolic slope, a load-independent marker of contractility, was measured as previously described, and the clinical outcomes were correlated. Results Between September 1, 2015 and August 23, 2019, a total of 10 patients underwent reverse ramp test at our institution per published protocol. Of these, 4 patients had adequate echocardiographic window of the LVAD outflow cannula, and the systolic slope was calculated. 3 of the 4 patients had outflow cannula systolic slope of 1200 cm/s2 (1788 cm/s2), and she underwent successful percutaneous decommission of her LVAD device (bottom figure). Conclusion In a small case series of 4 patients from reverse ramp database with available echocardiographic images of the outflow cannula, high systolic slope value (>1200 cm/s2) identified the patient with clinical recovery leading to successful LVAD decommission.
Identification of industrial robot frequency response function for robotic milling using operational modal analysis

Abstract Impact hammer experiments are typically used for identifying the Frequency Response Function (FRF) of six-degree-of-freedom (6-dof) industrial robots for machining applications. However, the modal properties of 6-dof industrial robots change as a function of robot arm configuration. Hence, describing the robot’s modal parameters within its workspace requires off-line impact hammer experiments performed at discrete robot end effector positions, which are costly and time consuming. Instead, it is more efficient to calculate the robot FRF using Operational Modal Analysis (OMA), a method that utilizes data acquired during the actual machining process. This paper presents an OMA approach to identify the robot FRF from measured milling forces and robot tool tip vibrations. Analysis of the milling process data reveal that periodic forces produced in the milling process are accompanied by background white noise that induce broadband excitation across the robot structure’s frequency spectrum. Hence, the tool tip vibration signal contains the signature of the structure’s free response that enables the use of OMA to estimate the robot’s FRF. The FRF calculated using OMA is shown to be in good agreement with results obtained from impact hammer experiments.
Cling performance and surface area of attachment in plethodontid salamanders

Plethodontid salamanders inhabit terrestrial, scansorial, arboreal, and troglodytic habitats in which clinging and climbing allow them access to additional food and shelter as well as escape from unfavorable temperature and moisture conditions and ground-dwelling predators. Although salamanders lack claws and toe pads found on other taxa, they successfully cling to and climb on inclined, vertical, and inverted substrates in nature. Maximum cling angle was tested on smooth acrylic, and the relationship between cling angle, body mass, and surface area of attachment (contact area) was investigated. This study found that many salamander species can cling fully inverted using only a portion of their ventral surface area to attach. Salamanders fall into three functional groups based on mass and maximum cling angle: (1) high performing, very small salamanders, (2) moderately high performing small and medium-sized salamanders, and (3) low performing large salamanders. They show significant differences in maximum cling angle, even between species of similar mass. In species of similar mass experiencing significantly different detachment stress (resulting from significantly different contact area), differences in morphology or behavior affect how much body surface is attached to the substrate. High performance in some species, such as Desmognathus quadramaculatus, is attributable to large contact area; low performance in a similarly sized species, Ensatina eschscholtzii, is due to behavior which negatively impacts contact area. There was not clear evidence of scaling of adhesive strength with increasing body size. Salamander maximum cling angle is the result of morphology and behavior impacting the detachment stresses experienced during clinging.
Pathfinding Model-Based Mission Assurance: S&MA Representation & Interaction within MBSE

The Model-Based Mission Assurance (MBMA) Program, led by John Evans within the Office of Safety and Mission Assurance (OSMA) at NASA is leading the charge in terms of integrating mission assurance into MBSE for flight projects. While OSMA operates with a charter at the agency level, the JPL contingency of support, including Steve Cornford and Nicholas Waldram, has a unique role in tying MBSE into the S&MA discipline. One of the advantages of operating within JPL is the exposure to flight projects which have adopted MBSE into several phases of the project lifecycle. Europa Clipper is currently in Phase B, utilizing the largest implementation of MBSE on a JPL flight project, simultaneously innovating the technology space and pathfinding for future efforts by constructing and developing the supra-model architectures with plugins such as the Europa Validation Framework (EVF), which is used to efficiently validate a large, complex model quickly and thoroughly. Besides the project level insight and resources, JPL has also invested significantly into MBSE from three distinct angles, via the Computer Aided Engineering (CAE) team, the Integrated Model-Centric Engineering (IMCE) group, and the Innovation Foundry. Through our development we have utilized the expertise and advice of the CAE to guide us towards sound modeling approaches and greatly enhanced tool integration to meet stakeholder needs. To broaden our thinking “beyond the gates” of JPL and to test our thinking on an agency level we have become involved with the NASA's agency-wide MBSE Infusion and Modernization Initiative (MIAMI). Through our work in the Cross Lifecycle Modeling (CLM) team we have been able to develop and test out our technologies and modeling patterns. While facing a number of configuration management hurdles in gaining and distributing access to our various tools which lie behind JPL firewalls, these difficulties have proven useful in terms of understanding limitations and how to circumvent these issues. The ground-level technology troubleshooting is critical to realize a tangible stakeholder integration.
Large-degree asymptotics of rational Painlevé-II functions: Noncritical behaviour

This paper is a continuation of our analysis, begun in Buckingham and Miller (2014 Nonlinearity 27 2489–577), of the rational solutions of the inhomogeneous Painleve-II equation and associated rational solutions of the homogeneous coupled Painleve-II system in the limit of large degree. In this paper we establish asymptotic formulae valid near a certain curvilinear triangle in the complex plane that was previously shown to separate two distinct types of asymptotic behaviour. Our results display both a trigonometric degeneration of the rational Painleve-II functions and also a degeneration to the tritronquee solution of the Painleve-I equation. Our rigorous analysis is based on the steepest descent method applied to a Riemann–Hilbert representation of the rational Painleve-II functions, and supplies leading-order formulae as well as error estimates.
A molecular bonding theory for liquid thallium–tellurium alloys: II. Thermal equilibrium of broken te–te bonds

A theory is derived for the dependence of the equilibrium concentration of broken Te–Te bonds on temperature and composition, which is appropriate for a mixture of chain molecules in which each cha...
The effects of personal information management capabilities and social-psychological factors on accounting professionals’ knowledge-sharing intentions: Pre and post COVID-19

Abstract Given the increased emphasis on individual factors in knowledge management research, this study proposes a research model that examines the effects of personal information management capabilities and social-psychological factors on the knowledge-sharing intention of accounting professionals. The survey results from 136 accounting professionals reveal that both personal information management capabilities and perceived image can positively influence knowledge-sharing behavior. Conversely, reciprocity and loss of knowledge power do not exhibit a significant role in knowledge-sharing intentions. The comparison analyses between pre- and post-COVID-19 sample groups indicate similar results for the hypothesized relationships while there are notable mean differences in knowledge sharing intention, image and information processing capabilities. This study extends current research by incorporating personal information management capabilities to examine the power of the “individual” in knowledge sharing and offers timely evidence of accounting professionals’ personal knowledge management practices during the period of COVID-19. This study raises implications for researchers and practitioners interested in knowledge management in the accounting profession.
A Cautionary Tale of Decorrelating Theory Uncertainties

A variety of techniques have been proposed to train machine learning classifiers that are independent of a given feature. While this can be an essential technique for enabling background estimation, it may also be useful for reducing uncertainties. We carefully examine theory uncertainties, which typically do not have a statistical origin. We will provide explicit examples of two-point (fragmentation modeling) and continuous (higher-order corrections) uncertainties where decorrelating significantly reduces the apparent uncertainty while the actual uncertainty is much larger. These results suggest that caution should be taken when using decorrelation for these types of uncertainties as long as we do not have a complete decomposition into statistically meaningful components.
Survey of COVID-19 impact on pediatric urology services

Introduction To better understand how the COVID-19 pandemic has forced rapid operational changes in the global healthcare industry, changes implemented on an individual, institutional basis must be considered. There currently is not adequate literature about the overall impact COVID-19 has had on pediatric urology services worldwide. We believe that they have dramatically decreased during the COVID-19 crisis, but have adapted to accommodate changes. We hypothesize that patient care was widely variant due to inadequate standardized recommendations or crisis planning. Materials and methods A web-based survey was deployed to 377 pediatric urologists globally via email to analyze COVID-19's impact on various types of pediatric urology practices. Key categories included impacts on elective services, telemedicine use, finances, and recovery operations. A total of 114 responses were collected between April 29th - May 22nd, 2020. Results The widespread cancellation of elective surgical procedures caused significant disturbances in the field. There was a uniform, significant increase (75%) in telemedicine use across practices. The pandemic has created many changes in care provision for physicians, institutions, and patients themselves. Furthermore, the sudden economic burden on healthcare facilities could lead to cost-cutting measures, creating further strain within institutions. Though telemedicine has its limitations, it is a very viable option when traditional services are unavailable. Conclusions Immediate steps should be taken to ensure that the recovery phases of pediatric urology practices are as efficient as possible. Institutions should develop task forces to develop critical workflow processes in the event of health crises, while still maintaining patient-centered care. This will be essential in maximizing appropriate care allocation.
Curbing Claims Of Causal Direction Stemming From A Technique With Panel Data (WITHDRAWN)

A growing number of researchers in organizational science have begun using a statistical routine to support inferences of causal direction. The technique involves partialling a prior observation of...
Actaeon in the Studio of Diana

ok, here's what happened. Jove, back at the penthouse after 171 another romp with Europa, found the atmosphere at Parnassus a bit pent-up. Juno was exceedingly cool and at bedtime downright snarly around the edges. Suspicious that Diana might be the cause of his wife's icy demeanor, Jove sent Echo downtown to hang out at the goddess's west side studio. Echo confirmed everything. Thanks to Diana and her feminist buddies, word of Jove's totally bullish and unacceptable behavior had made the rounds. Peeved, Jove plotted payback. Everyone knew that?hunting aside?Diana and her circle had but two pleasures: putting down the guys and drawing. As Echo reiterated again and again: when these ladies talked they trashed, and when they drew they drew each other.
Public Choice of Tax and Regulatory Instruments—The Role of Heterogeneity: Evidence from U.S. State Environmental Policy, 1980-1994

In the authors' political equilibrium model, regulation is considered an implicit and regressive tax-equivalent alternative to the common and less regressive fiscal alternatives: income, property, and sales taxes. The authors hypothesize that in more heterogeneous jurisdictions the state relies more on regulation and less on budgetary spending than in more homogeneous units. Using data drawn from U.S. state-level environmental policy from 1980 to 1994, the authors confirm this hypothesis.
The Influence of Bleaching Agent and Temperature on Bleaching Efficacy and Volatile Components of Fluid Whey and Whey Retentate

Fluid whey or retentate are often bleached to remove residual annatto Cheddar cheese colorant, and this process causes off-flavors in dried whey proteins. This study determined the impact of temperature and bleaching agent on bleaching efficacy and volatile components in fluid whey and fluid whey retentate. Freshly manufactured liquid whey (6.7% solids) or concentrated whey protein (retentate) (12% solids, 80% protein) were bleached using benzoyl peroxide (BP) at 100 mg/kg (w/w) or hydrogen peroxide (HP) at 250 mg/kg (w/w) at 5 °C for 16 h or 50 °CC for 1 h. Unbleached controls were subjected to a similar temperature profile. The experiment was replicated three times. Annatto destruction (bleaching efficacy) among treatments was compared, and volatile compounds were extracted and separated using solid phase microextraction gas chromatography mass spectrometry (SPME GC-MS). Bleaching efficacy of BP was higher than HP (P 0.05). Retentate bleached with HP at either temperature had higher relative abundances of pentanal, hexanal, heptanal, and octanal than BP bleached retentate (P < 0.05). Liquid wheys generally had lower concentrations of selected volatiles compared to retentates. These results suggest that the highest bleaching efficacy (within the parameters evaluated) in liquid whey is achieved using BP at 5 or 50 °C and at 50 °C with HP or BP in whey protein retentate. Practical Application Benzoyl peroxide and hydrogen peroxide are the two chemical bleaching agents approved for bleaching whey in the United States. Previous studies have shown less norbixin destruction and increased off-flavor production using HP compared to BP in liquid whey. No published studies have compared bleaching parameters of liquid whey and whey retentate. BP is an effective bleaching agent in fluid whey or retentate at 5 or 50 °C. In contrast, optimal bleaching with HP occurs in whey protein retentate (12% solids, 80% protein). Decreased production of lipid oxidation volatiles occurred at 5 °C compared to 50 °C with HP bleaching and suggests that HP bleaching in whey protein retentate should occur at colder temperatures (5 °C).
Looking Back to the Future: Current Issues Facing Nursing Education From the Reflections of a Member of the Silent Generation.

KeatingProblem As a member of the Silent Generation, the author, through her lived experiences, reflects upon the successes and challenges facing nursing education in the mid-20th to 21st centuries. Method The author looks “back to the future” and reviews current issues that surround four key nursing education milestones. Findings From the early entry-level baccalaureate programs in the 1950s to the current growth of the Doctor of Nursing Practice as entry into advanced practice, milestones in nursing education are linked to the cultural changes and healthcare system demands that took place at the time and their influence on nursing education and the profession. Conclusion Looking to the future, the author speaks of the implications from the forecasted changes in the healthcare system that will demand interdisciplinary education and practice and the continued need for nursing research to increase the body of scientific knowledge in practice, education, and technology. Keating
Holy Cows: A Look at the Influence of Religious Beliefs on Dairy Animal Welfare on Kibbutzim in Israel

The influence of religious beliefs on people's attitudes andactions in the area of animal welfare was examined by interviewing dairyworkers on kibbutzim (communal agricultural settlements) in Israel.Workers on religiously observant kibbutzim were no more consistent intheir attitudes toward and treatment of dairy cows than workers onnon-observant and selectively observant kibbutzim.