cssi/SciSciGPT-SciSciNet huggingface dataset:
Fraternal twins with job’s syndrome and immune complex nephritis

Job's syndrome or autosomal dominant hyperimmunoglobulin E syndrome (Hyper-IgE) is a rare disorder that results from a STAT3 gene mutation, which results in the absence of T-helper 17 (Th17) cells and manifests as a severe immunodeficiency. Affected individuals suffer recurrent soft tissue and pulmonary infections among other manifestations, and the spectrum of the disease is still being characterized. We describe 2 sisters with Job's syndrome each with variable expressivity. However, both patients developed proteinuric kidney disease and had biopsies confirming the presence of immune complex glomerulonephritis with staining for immunoglobulins and complement components. Previous reports link Job's syndrome and the development of systemic lupus erythematosus (SLE), but proliferative immune complex glomerulonephritis has not been described. We speculate that continual internal and external antigen exposure may induce an autoimmune process similar to SLE, which in turn may account for the immune complex disease in the kidney.
The effect of chronic treatment with clozapine and haloperidol on stimulus control by DOM.

The present study investigated the effects of chronic treatment with the atypical antipsychotic, clozapine, or the typical antipsychotic, haloperidol, on the stimulus properties of 2,5-dimethoxy-4-methylamphetamine ([-]-DOM) in rats trained to discriminate [-]-DOM (0.3 mg/kg; 75 min pre-treatment time) from vehicle. As compared with control values, treatment with clozapine (25 mg/kg.d) for 7 d caused a statistically significant 57% reduction in [-]-DOM-appropriate responding. Unlike clozapine, treatment with haloperidol (1 mg/kg.d) for 7 d did not affect the stimulus properties of [-]-DOM. These findings demonstrate that a functionally significant decrease in 5-HT2A receptor-mediated activity is a unique component of the in-vivo response to chronic treatment with clozapine but not haloperidol and, therefore, might account for some of the clinical differences associated with atypical antipsychotics.
Regulated Heterogeneity in 12-kDa P-protein Phosphorylation and Composition of Ribosomes in Maize (Zea mays L.)

Maize (Zea mays L.) possesses four distinct approximately 12-kDa P-proteins (P1, P2a, P2b, P3) that form the tip of a lateral stalk on the 60 S ribosomal subunit. RNA blot analyses suggested that the expression of these proteins was developmentally regulated. Western blot analysis of ribosomal proteins isolated from various organs, kernel tissues during seed development, and root tips deprived of oxygen (anoxia) revealed significant heterogeneity in the levels of these proteins. P1 and P3 were detected in ribosomes of all samples at similar levels relative to ribosomal protein S6, whereas P2a and P2b levels showed considerable developmental regulation. Both forms of P2 were present in ribosomes of some organs, whereas only one form was detected in other organs. Considerable tissue-specific variation was observed in levels of monomeric and multimeric forms of P2a. P2b was not detected in root tips, accumulated late in seed embryo and endosperm development, and was detected in soluble ribosomes but not in membrane-associated ribosomes that copurified with zein protein bodies of the kernel endosperm. The phosphorylation of the 12-kDa P-proteins was also developmentally and environmentally regulated. The potential role of P2 heterogeneity in P-protein composition in the regulation of translation is discussed.
The test-retest reliability of the Mini-Mental State Examination in chronic schizophrenic patients

The test-retest reliability of the Mini-Mental State Examination (MMSE) was explored in a sample of 22 inpatients suffering from chronic schizophrenia by DSM-III-R criteria. Patients were tested 4 times during a period of 4-6 weeks. The total score for serial sevens showed consistently significant reliability at about 0.7, and the total score for spelling displayed a lower reliability at about 0.4, which was of borderline significance. In this short period of time, 36% and 27% of the patients shifted between being demented and nondemented when the serial sevens and spelling, respectively, were used to calculate total scores. The MMSE should not be used to categorize schizophrenics as demented or nondemented in biological studies using relatively stable variables.
Supervision: Supervision and Clinical Practicum in Telepractice

This article describes how a telepractice pilot project was used as a vehicle to train first-year graduate clinicians in speech-language pathology. To date, six graduate clinicians have been traine...
A generalized framework for hybrid simulation of multi-component structures using iterative field refinement

When applying computational simulation techniques to scattering or radiation problems, it is often possible to decompose a complicated geometry into simpler elemental structures (i.e., a helicopter rotor system into its individual blades). By then simulating each component separately, a given problem can be decomposed into smaller and more manageable components, as long as account is taken of the coupling between each component. To implement such coupling, this paper describes a generalized iterative field refinement (IFR) framework, and demonstrates how it can be used as a basis for many hybrid approaches. Within this framework, IFR can also be used to accelerate simulation of geometries made up of rotated, translated, reflected, or replicated versions of a given structure. Several examples are given to show that an approach built around IFR reduces total computation time while allowing the combination of different analysis methods in treating each of the separate components comprising the structure
Fighting the Last War

It would be nice to get rid of passwords entirely, but that isn't going to happen any time soon. What we need are better ways of entering, storing, and using passwords, ways that respond to today's threats instead of yesterday's. Sticking with checklists based on yesterday's technology is not the way to secure today's systems.
Symbol mapping diversity design for packet retransmissions through fading channels

We present a simple, but effective, method of enhancing and exploiting diversity from multiple packet transmissions in systems that employ nonbinary linear modulations such as PSK and QAM. This diversity improvement results from redesigning the symbol mapping for each packet transmission. Using a general framework for evaluating the upper bound of bit error rate (BER) with multiple transmissions, a criterion to obtain optimal symbol mappings is attained. The optimal adaptation scheme reduces to solving the well known quadratic assignment problem (QAP). Symbol mapping adaptation only requires a small increase in receiver complexity but provides very substantial BER gains when applied to flat-fading channels.
Spin- and isospin-polarized states of nuclear matter in the Dirac-Brueckner-Hartree-Fock model

Spin-polarized isospin asymmetric nuclear matter is studied within the Dirac-Brueckner-Hartree-Fock approach. After a brief review of the formalism, we present and discuss the self-consistent single-particle potentials at various levels of spin and isospin asymmetry. We then move to predictions of the energy per particle, also under different conditions of isospin and spin polarization. Comparison with the energy per particle in isospin symmetric or asymmetric unpolarized nuclear matter shows no evidence for a phase transition to a spin-ordered state, neither ferromagnetic nor antiferromagnetic.
Modeling system performance in MMORPG

Massive multiplayer online games are becoming popular and prosperous rapidly. Although many papers have been published on system performance for online games in recent years, most of them are focusing on network perspective in first personal shooter (FPS) or strategy games. This paper describes a method to modeling network traffic and game server performance in a standard MMORPG (massive multiplayer online role play game). Experimental results show that there exists strong linear relationship between performance metrics in server side and the concurrent player number online. Utilization of two kinds of resources, including network traffic and server, can be calculated via using the concurrent player number as a determinative variable. Player-related distribution patterns are also analyzed which form the basis for resource provisioning and load balancing.
Classification in High-Dimensional Feature Spaces: Random Subsample Ensemble

This paper presents application of machine learning ensembles, which randomly project the original high dimensional feature space onto multiple lower dimensional feature subspaces, to classification problems with high-dimensional feature spaces. The motivation is to address challenges associated with algorithm scalability, data sparsity and information loss due to the so-called curse of dimensionality. The original high dimensional feature space is randomly projected onto a number of lower-dimensional feature subspaces. Each of these subspaces constitutes the domain of a classification subtask, and is associated with a base learner within an ensemble machine-learner context. Such an ensemble conceptualization is called as random subsample ensemble. Simulation results performed on data sets with up to 20,000 features indicate that the random subsample ensemble classifier performs comparably to other benchmark machine learners based on performance measures of prediction accuracy and cpu time. This finding establishes the feasibility of the ensemble and positions it to tackle classification problems with even much higher dimensional feature spaces.
Does estrogen deficiency cause lacrimal gland inflammation and aqueous-deficient dry eye in mice?

Researchers have proposed that estrogen deficiency will lead to a Sjogren's syndrome (SjS)-like lacrimal gland inflammation, aqueous tear deficiency and dry eye. The purpose of this study was to determine whether this proposal is correct. Lacrimal glands were obtained from adult, age-matched wild type (WT) and aromatase knockout (ArKO) mice, in which estrogen synthesis is completely eliminated. Tissues were also obtained from autoimmune MRL/Mp-lpr/lpr (MRL/lpr) mice as inflammation controls. Tear volumes in WT and ArKO mice were measured and glands were processed for molecular biological and histological evaluation. Our results demonstrate that estrogen absence does not lead to a SjS-like inflammation in lacrimal tissue or to an aqueous-deficient dry eye. There was no upregulation of genes associated with inflammatory pathways in lacrimal glands of male or female ArKO mice. Such inflammatory activity was prominent in autoimmune MRL/lpr tissues. We also found no evidence of inflammation in lacrimal gland tissue sections of estrogen-deficient mice, and tear volumes of ArKO males were actually increased as compared to those WT controls. Interestingly, our study did show that estrogen absence influences the expression of thousands of lacrimal gland genes, and that this impact is sex- and genotype-specific. Our findings demonstrate that estrogen absence is not a risk factor for the development of SjS-like lacrimal gland inflammation or for aqueous-deficient dry eye in mice.
Headaches in Patients With Shunts

Headache is one of the most common afflictions suffered by humans. Headache in patients with a shunt triggers a series of events that includes utilization of expensive technologies and often potentially dangerous surgical intervention. The purpose of this study was to determine the incidence of headaches in patients with shunts and, hopefully, the relationship of those headache disorders to the treatment of hydrocephalus. The Hydrocephalus Association maintains a self-reporting database recorded from individuals treated for hydrocephalus and their families. This database was mined to determine the incidence of severe headaches requiring treatment and interfering with normal life in patients who have been treated for hydrocephalus. There were 1,242 responders between the ages of 19 months and 45 years of age. Of these, 1,233 answered the question, "Do you or your family member suffer from (does your child complain of) frequent or chronic headaches?" This subset forms the basis of this study. Three groups were defined by age: children (19 months-12 years), adolescents (13 years-19 years), and young adults (20 years-45 years). Most respondents were initially treated during infancy (before 18 months of age); 84% of children and 69% of both adolescents and young adults were treated very early in life. Severe headaches became a more frequent problem as the age of the population treated for hydrocephalus increased. In terms of frequency and severity of headaches, direct comparisons with epidemiologic studies of normal populations are difficult because of the limitations of data available in the database. However, it is likely that this population has a higher incidence of severe headaches than normal populations. The cost of management of headaches in this population is very high, and the patients are at risk throughout life. Early treatment decisions have a significant effect on later quality of life. Strategies that lead to normalization of cerebrospinal fluid dynamics and life without shunt dependency are justified if they can be shown to improve later quality of life.
E-Leaders and Uncertainty Management: A Computer-Supported Qualitative Investigation

Organizations are experiencing more online activity requiring more digital communication than ever before. Due to these increasing electronic experiences and the uncertainties that result for elect...
HOST SPECIFICITY AND THE DISTRIBUTION–ABUNDANCE RELATIONSHIP IN A COMMUNITY OF PARASITES INFECTING FISHES IN STREAMS OF NORTH CAROLINA

A positive relationship between distribution and local abundance is often observed among species in a community. The resource-breadth hypothesis suggests that this pattern is the result of differential abilities among species to utilize available resources, such that generalists are widely distributed and locally abundant, and specialists are narrowly distributed and locally sparse. This hypothesis was tested in a community consisting of 22 species or morphospecies of parasites infecting members of 18 species of fish among 14 sites in 7 small streams in the Appalachian Mountains of North Carolina. A positive relationship between distribution (fraction of sites occupied) and abundance (average local abundance) was evident among parasite species. The number of host species infected by each parasite species was positively related to both distribution and average local abundance; both relationships held after statistical removal of the distribution and abundance of the hosts, respectively. These results suppo...
U.S. Intervention in the Middle East, the “War on Terror,” and Domestic Hate Crimes: An Amerasia Journal Chronology

Today, as President Bush wages his "War on Terror," this model of "worthy" and "unworthy" victims is a useful tool for understanding how mass media information (and disinformation) operates on a selective basis. News networks no longer strive for journalistic objectivity; rather, zealous patriotism overshadows any attempts to present a balanced view. As Fox News Network executives puts it, to be unequivocally fair and balanced is to participate in the worst kind of cultural relativism. In light of this "U.S.A. Fever," it is no wonder that for all the generous coverage President Bush receives on his many calls for racial tolerance, there is remarkably little in print on the over 1,000 people who have been detained by Attorney General John Ashcroft since September 11, the vast majority of whom are of South Asian and Middle Eastern descent. The murmured consensus around the nation seems to be "you're either with us, or against us."
Effect of 6α-methyl-17α-hydroxyprogesterone on urinary excretion of luteinizing hormone

In order to determine the mechanism whereby intramuscular injection of a long-acting medroxyprogesterone inhibits ovulation, daily immunoassay of urinary excretion of LH was performed on 4 subjects. During two control cycles prior to treatment, a midcycle peak of LH excretion was observed at the approximate time of ovulation in all subjects. After treatment with 150 mg. of Depo-Provera, there was no peak of LH excretion observed in any subject during the time the drug was active. In the two subjects who had assays continued until ovulation resumed, there was again evidence of a peak in LH excretion at the time of ovulation. This study indicates that medroxyprogesterone acetate administered in this dosage acts as a contraceptive by inhibiting release of LH.
Elastic Scattering of Alpha Particles by O 16

Absolute cross sections for the elastic scattering of alpha particles by ${\mathrm{O}}^{16}$ have been measured in a differentially pumped gas scattering chamber. The measurements were made for laboratory energies from 3.7 to 6.5 Mev, corresponding to 7.7- to 9.9-Mev excitation in ${\mathrm{Ne}}^{20}$, at center-of-mass angles of 168.9\ifmmode^\circ\else\textdegree\fi{}, 149.4\ifmmode^\circ\else\textdegree\fi{}, 140.8\ifmmode^\circ\else\textdegree\fi{}, 125.3\ifmmode^\circ\else\textdegree\fi{}, and 90.0\ifmmode^\circ\else\textdegree\fi{}.
Extreme Temporal Pulse Propagation in Quadratic Nonlinear Media

The interplay of quadratic and cubic nonlinearities underlies new effects in short-pulse propagation. Pulse propagation governed by an integrable derivative nonlinear Schrodinger equation is studied for the first time in any physical setting.
Tomato Fruitworm: Control in South Carolina with Chemical and Microbial Insecticides 1970-1971

Sprays of leptophos, methomyl, and carbaryl + a commercial formulation of Bacillus thuringiensis var. alesti Berliner (Dipel®) and baits containing CSM + methomyl and CSM + carbaryl + Dipel were as effective as a conventional spray of DDT for control of Heliothis zea (Boddie). Also, sprays of acephate and Dipel alone or with chlordimeform hydrochloride appeared promising. A bait that contained CSM + ¼ lb AI/acre of methomyl was as effective as a bait that contained CSM + 1 lb AI/acre of methomyl or a spray that contained 1 lb AI/acre of methomyl. Carharyl spray alone was significantly less effective than DDT spray in 1970 and methomyl spray in 1971. Sprays of resmethrin, chlordimeform hydrochloride, and chlordimeform, and a bait containing CSM + resmethrin failed to protect the fruit effectively. The nuclear polyhedrosis virus of H. zea (Biotrol® VHZ) was more effective as a spray than in a bait; however, neither treatment gave satisfactory control.
Distributed Network Design for Laplacian Eigenvalue Placement

We propose a distributed iterative algorithm in which a group of $n$ autonomous agents self-organize the structure of their communication network in order to control the network's Laplacian eigenvalue spectrum. We assume that every agent has only access to a local (“myopic”) view of the network around it and that there is no centralized coordinator. With every iteration of our algorithm, the agents share local information about their myopic views of the network in order to distributedly find the most beneficial global edge addition/deletion, defined as the one that minimizes a pseudometric defined in the space of Laplacian spectra. The proposed pseudometric is defined in terms of the Laplacian spectral moments and allows for an efficient distributed implementation. The proposed approach is greedy in nature and stable by construction, that is, it locally minimizes the distance of the network's eigenvalue spectrum to a desired spectrum. We illustrate the performance of our approach with several numerical simulations.
Education and Training in Otorhinolaryngology —The Scope of Otorhinolaryngology and IFOS Education Committee Tasks

Otorhinolaryngology (ORL) is that discipline of medicine and surgery which addresses disorders and surgery of the head and neck, and bronchoesophagology.
The second generation of Carolina Rinse, solution II, improves graft survival following orthotopic liver transplantation in the rat by preventing reperfusion injury.

Carolina Rinse solution was designed to minimize reperfusion injury following orthotopic liver transplantation. Carolina Rinse blocks reperfusion-induced endothelial cell killing, diminishes postoperative enzyme release and improves survival dramatically. Adenosine and mildly acidotic pH were identified as key components. Here we report results with a simplified formulation, Carolina Rinse II, which contains extracellular inorganic ions similar to Ringer’s solution, adenosine, as well as antioxidants and radical scavengers (allopurinol, glutathione and desferrioxamine). In this study, 44 rat livers were explanted and stored for 12 h in University of Wisconsin (UW) cold storage solution (non-survival conditions). Control livers were rinsed with 15 ml cold Ringer’s solution just prior to completion of implantation surgery. In this control group, average 30-day survival was poor (8%). However, survival was increased to around 60% when grafts were rinsed with Carolina Rinse II. Survival was not improved significantly by rinsing the graft with Ringer’s solution containing antioxidants and radical scavengers with adenosine omitted (about 30%). Peak SGOT values of nearly 3000 U/l, measured 1–3 days postoperatively in the Ringer’s rinse control group, were decreased 4- to 5-fold both by Carolina Rinse II and by Ringer’s solution containing antioxidants. On the other hand, the addition of adenosine to Ringer’s solution improved survival (around 60%) but did not decrease the postoperative elevation of serum enzymes significantly. Thus, it appears that adenosine was necessary for optimal survival whereas antioxidants and radical scavengers were needed to prevent injury to the transplanted graft. These data were consistent with the hypothesis that at least two mechanisms, one involving the liver and a second one non-hepatic, are responsible for post-transplant pathophysiology. Carolina Rinse II also reduced the postoperative elevation in serum enzymes 2- to 3-fold in livers stored under survival conditions (e.g., for 8 h in UW solution). This study demonstrated convincingly that a very simple rinse solution, Carolina Rinse II, improved survival significantly and minimized graft injury following orthotopic liver transplantation.
Pharmacologic Therapy of Type 2 Diabetes

Type 2 diabetes (T2DM) is a common condition. Treatment of diabetes and related complications can be complex. In addition to lifestyle changes, medications play an important role in controlling patients' blood glucose levels and preventing complications. From an individual and societal standpoint, it is also an expensive disease. Medical spending attributed to diabetes per individual is significant. With appropriate therapy, patients can lead full, healthy lives with the disease, so making informed decisions regarding pharmacotherapy for T2DM is clearly of great importance.
When Supervisors and Managers Tolerate Heterosexism: Challenges, Opportunities, and Implications for Workplace Advocacy

Heterosexism is part of the social foundation of many organizations and institutions in the United States and worldwide, yet the extent to which that behavior is tolerated by supervisors and managers is less known. Heterosexism refers to attitudes and beliefs that privilege heterosexual identities and norms while discrediting the identities and norms of sexual minorities. Though not all workplace environments are negative for lesbian, gay, and bisexual (LGB) workers, many workers share the knowledge that sexual minorities have been historically considered bad, sick, immoral, or inferior to heterosexuals. This shared cultural knowledge impacts the extent to which heterosexism by managers and supervisors is accepted or tolerated by workers. This chapter reports the results of an empirical study of a convenience sample (n = 247) of upstate New York workers’ experiences of organizational tolerance for a supervisor’s heterosexist behaviors. In addition, the chapter considers how the results of the present study may offer insight for how human resource professionals, organizational behavior consultants, social workers, and other workplace advocates can advance organizational policies that better protect LGB workers.
Lean Sigma Project Design

The purposes of this chapter are: (1) to describe six sigma strategy and (2) to propose opportunities for additional research and evolution of six sigma. Part I of this book describes several methods that can structure activities within a project. Part II focuses on design of experiment (DOE) methods that can be used inside six sigma projects. DOE methods are complicated to the extent that decision-making about them might seem roughly comparable to decision-making about an entire project.
Enzyme-Based Electrochemical Biosensor with DNA Array Chip

A reusable DNA sensor array# for rapid biological agent detection has been fabricated on a silicon chip.(Fig.1) The DNA-based probes target the DNA/RNA sequence of the analyte instead of indirect probing using antibodies. The sensitivity is greatly enhanced by combining the hybridization event with a signal enzyme. The formation of the self-assembled monolayer sensor surface, in-situ DNA hybridization, signal measuring and the sensor regeneration can be performed within 40 minutes. Even without using the PCR, as low as 1000 Escherichia coli (E. coli) cells through 16s rRNA can be detected using this sensor array.(Fig.2) The dimension of each sensor area ranges from 25 mm2 to 160) μm2.
Management of terrible triads

The term “terrible triad of the elbow” describes the combination of a traumatic elbow dislocation, radial head fracture, and associated coronoid fracture. This chapter focuses on the evaluation, treatment options, published outcomes, and complications of terrible triad injuries of the elbow. A systematic approach to the management of this injury complex is provided, with an emphasis on the understanding of the pathoanatomy and current surgical treatments.
Total Quality Management and Continuous Quality Improvement

Dissatisfaction with traditional quality assurance has led administrators to apply other industrial models of quality management to the health care field (Thompson, et al., 2000). Two such models from industry are total quality management (TQM) and continuous quality improvement (CQI). The concepts ofTQM and CQI are often thought of as the same, but they are not. TQM has been as defined as “the management philosophy and system that promotes positive organizational change, as well as an effective cultural environment, for continuous improvement of all aspects of the organization.” CQI has been defined as “a systematic approach to the measurement, evaluation and improvement of the quality of all products and services, through the use of disciplined inquiry and teamwork” (Gift, 1992).
A Multitheoretical Approach to Big Text Data: Comparing Expressive and Rhetorical Logics in Yelp Reviews:

This article uses a multitheoretical approach to investigate the relationship between language use and opinion expression on Yelp. Using review metadata (e.g., star rating) to observe variation in reviewer feelings and motivations, we test for the strength of different message design logics: expressive logics, where language reflects a reviewer’s underlying opinion, and rhetorical logics, where language reflects a reviewer’s desire to make his or her opinion credible and acceptable to their audience. Results suggest that emotional language is motivated by expression as higher rated businesses are reviewed with more positive and fewer negative emotion terms. Rhetorical logics are associated with the use of abstract and self-focused language, with analysis suggesting this may result from the reviewer’s decision to write either narratively or formally.
Negative regulation of the RLH signaling by the E3 ubiquitin ligase RNF114

The retinoic acid-inducible gene-I (RIG-I)-like helicases (RLH)s are cytoplasmic pattern recognition receptors expressed in both immune and non-immune cells that are essential for detection of intracellular RNA products, primarily of viral origin. Upon binding to viral RNA, RLHs interact with mitochondrial antiviral signaling protein (MAVS) to activate interferon (IFN)-mediated antiviral responses. The RLH/MAVS signaling pathway is regulated by ubiquitination/deubiquitination, in which several ubiquitin-editing proteins play critical roles. The really interesting new gene (RING) finger protein 114 (RNF114) was originally identified as a psoriasis susceptibility gene broadly expressed in human tissues. Earlier studies implicated RNF114 in regulating cellular dsRNA responses, cell cycle progression, NF-κB activity and T-cell activation. We found that RNF114 inhibited cellular dsRNA responses and RLH-mediated IFN production. RNF114 functioned as an E3 ubiquitin ligase, and MAVS was identified as a potential target for RNF114-mediated polyubiquitination and degradation. Splenocytes and blood harvested from RNF114 KO showed increased basal IFN level and sensitized responses to dsRNA. However, RNF114 knockout mice failed to exhibit enhance resistance to infection by two acute RNA viruses. These data suggested the potential physiological function of RNF114 in inflammation and host antiviral responses, but demonstrate complexity in the regulation of innate immunity by ubiquitin ligases.
Integrin binding: Sticking around vessels.

A study demonstrates that controlled integrin binding on a biomaterial was capable of promoting vascular cell sprouting and formation of a non-leaky blood vessel network in a healthy and diseased state.
Bully Perpetration and Self-Esteem: Examining the Relation over Time.

School-aged youth face a number of academic and behavioral challenges within the educational environment, including bullying involvement. Unfortunately, bullying has been linked to a number of detr...
Observation of the Quantum Hall Effect in Confined Films of the Three-Dimensional Dirac Semimetal Cd3As2

Realizing the quantum Hall effect in topological materials is notoriously difficult due to remanent bulk conduction in the material. This feat has now been achieved in a Dirac semimetal by growing a sufficiently thin film of the material, thus eliminating bulk conduction.
La exaltación gastronómica de Leonardo Padura: tras la pista de sus festines pantagruélicos

Leonardo Padura Fuentes, a contemporary Cuban writer, delivers a series of novels that have been classified by critics under the epithet of “detective novel.” Though this is indeed true, it must be stressed that there are certain textual clues that seem not to resonate with the detective fiction genre and could be perceived as incongruent with such categorization. Nevertheless, it is one of these clues, as a fundamental conduit, upon which this study is based, a study that focuses primarily on gastronomic disarticulation.
Targeting TWIST1 through loss of function inhibits tumorigenicity of human glioblastoma.

TWIST1 (TW) is a bHLH transcription factor (TF) and master regulator of the epithelial-to-mesenchymal transition (EMT). In vitro, TW promotes mesenchymal change, invasion, and self-renewal in glioblastoma (GBM) cells. However, the potential therapeutic relevance of TW has not been established through loss-of-function studies in human GBM cell xenograft models. The effects of TW loss of function (gene editing and knockdown) on inhibition of tumorigenicity of U87MG and GBM4 glioma stem cells were tested in orthotopic xenograft models and conditional knockdown in established flank xenograft tumors. RNAseq and the analysis of tumors investigated putative TW-associated mechanisms. Multiple bioinformatic tools revealed significant alteration of ECM, membrane receptors, signaling transduction kinases, and cytoskeleton dynamics leading to identification of PI3K/AKT signaling. We experimentally show alteration of AKT activity and periostin (POSTN) expression in vivo and/or in vitro. For the first time, we show that effect of TW knockout inhibits AKT activity in U87MG cells in vivo independent of PTEN mutation. The clinical relevance of TW and candidate mechanisms was established by analysis of the TCGA and ENCODE databases. TW expression was associated with decreased patient survival and LASSO regression analysis identified POSTN as one of top targets of TW in human GBM. While we previously demonstrated the role of TW in promoting EMT and invasion of glioma cells, these studies provide direct experimental evidence supporting protumorigenic role of TW independent of invasion in vivo and the therapeutic relevance of targeting TW in human GBM. Further, the role of TW driving POSTN expression and AKT signaling suggests actionable targets, which could be leveraged to mitigate the oncogenic effects of TW in GBM.
A repeated stochastic game approach for strategic network selection in heterogeneous networks

Nowadays most mobile devices are equipped with multiple network interfaces such as cellular network interface, Wi-Fi interface, and Ethernet. An access network selection mechanism is required during the transmission phrase to provide the best performance and resource utilization. In this paper, we model the access network selection problem as a repeated stochastic game with consideration of optical networks, terrestrial wireless networks, airborne networks and satellite networks. With the goals of maximizing total user utility and achieving maximum proportional fairness, the access network selection problem is solved using the Lyapunov optimization algorithm. Simulation results demonstrate that the proposed repeated stochastic game approach achieves higher total utility and larger proportional fairness index, compared to two benchmark schemes.
Parallel Algorithms and Implementations

ABSTRACT We describe parallelizations of three terminal-pair reliability algorithms. The BBN Butterfly GP1000, the parallel computer on which the parallel algorithms are implemented, is described first. After a review of the sequential algorithms, their parallel versions — along with implementation details like data structures — are described. The performance of the parallel algorithms is then compared with respect to their execution time and processor efficiency. We conclude this chapter with some potential research topics in parallelizing and implementing algorithms for reliability analysis.
Nuclease Digestion and the Structure of Chromatin

In a very short period in 1973–1974, a series of papers appeared that markedly changed our conceptions of the structure of chromatin (Hewish and Burgoyne, 1973; Sahasrabuddhe and Van Holde, 1974; Olins and Olins, 1974; Kornberg, 1974). The prevailing idea of a more or less uniform supercoil was quickly replaced by the concept of chromatin subunits, or “nucleosomes”. This model has now become firmly established, and the structures and properties of the subunits are known in considerable detail.
Diclofenac-Induced Post Infantile Giant Cell Hepatitis

INTRODUCTION: Post-infantile Giant Cell Hepatitis (PIGCH) is a rare type of autoimmune hepatitis (AIH) characterized by an idiosyncratic response to liver injury from various causes in which liver cells respond to insult by rapid proliferation and without the appropriate cellular division, leading to the formation of the multi-nucleated giant cells. We encountered a case of Diclofenac induced PIGCH in a patient with untreated seropositive rheumatoid arthritis. To the best of our knowledge, this is first such case reported in the literature. CASE PRESENTATION: A 48-year-old Hispanic woman with type II diabetes and rheumatoid arthritis, not on DMARDs presented with acute onset jaundice and right upper quadrant pain. She was taking 50mg of Diclofenac, 2 pills daily for the past 3 months and unknown quantity of garlic tablets. Workup for hepatitis including infectious and toxic etiologies were ruled out. Serum IgG levels were elevated with increased globuin gap, and positive ANA titer of 640, anti-smooth muscle cell antibodies elevated at 41 units (moderate to strong positive > 30 units). Liver biopsy demonstrated submassive necrosis in the setting of post-infantile giant cell hepatitis. The differential diagnoses included idiopathic autoimmune hepatitis, viral or drug induced injury. Our diagnosis was drug induced autoimmune liver disease (DIALD), the etiology is likely due to Diclofenac given temporal relationship of drug intake and symptom onset, as well as a calculated Roussel Uclaf Causality Assessment Method (RUCAM) score of 6, signifying probable drug-induced liver disease. Patient was started on Prednisone and Azathioprine with complete resolution of clinical and laboratory findings within 5 months. DISCUSSION: The outcome of PIGCH is unpredictable, usually adopts a fulminant course leading to cirrhosis within months, however, a more benign course has also been described. PIGCH is triggered by three primary etiologies: drugs, infection, and autoimmune liver injury. This case highlights that giant cell hepatitis is a multifactorial condition that can be precipitated by drug use in the setting of autoimmune phenotype. Garlic and garlic extracts, through their antioxidant activities, have been reported to provide protection against free radical damage in the body. The innocuous course of PIGCH in our patient could possibly be due to concurrent consumption of garlic tablets. Further research is needed in this area.
Facilitating feasibility analysis: the pilot defects prediction dataset maker

Our industrial experience in institutionalizing defect prediction models in the software industry shows that the first step is to measure prediction metrics and defects to assess the feasibility of the tool, i.e., if the accuracy of the defect prediction tool is higher than of a random predictor. However, computing prediction metrics is time consuming and error prone. Thus, the feasibility analysis has a cost which needs some initial investment by the potential clients. This initial investment acts as a barrier for convincing potential clients of the benefits of institutionalizing a software prediction model. To reduce this barrier, in this paper we present the Pilot Defects Prediction Dataset Maker (PDPDM), a desktop application for measuring metrics to use for defect prediction. PDPDM receives as input the repository’s information of a software project, and it provides as output, in an easy and replicable way, a dataset containing a set of 17 well-defined product and process metrics, that have been shown to be useful for defect prediction, such as size and smells. PDPDM avoids the use of outdated datasets and it allows researchers and practitioners to create defect datasets without the need to write any lines of code.
Contrast-Enhanced Ultrasound Imaging of Breast Masses: Adjunct Tool to Decrease the Number of False-Positive Biopsy Results.

Objectives This pilot study evaluated use of contrast-enhanced ultrasound (CEUS) to reduce the number of benign breast masses recommended for biopsy. Methods This prospective study included 131 consenting women, from October 2016 to June 2017, with American College of Radiology Breast Imaging Reporting and Data System category 4a, 4b, and 4c masses detected by mammography, conventional ultrasound (US), or both. Contrast-enhanced US examinations (using intravenous injection of perflutren lipid microspheres or sulfur hexafluoride lipid-type A microspheres) were performed before biopsy. Qualitative and quantitative CEUS parameters were compared with reference standard histopathologic results from biopsy of 131 masses. Results There were 109 benign, 6 high-risk, and 16 malignant masses, with a median size of 12 mm (range, 4 to 48 mm) on conventional US imaging. Of 131 masses, 93 (71%) enhanced on CEUS imaging, including 73 of 109 (67%) benign, 6 of 6 (100%) high-risk, and 14 of 16 (87.5%) malignant. Thirty-eight lesions did not enhance, including 36 of 109 (33%) benign and 2 of 16 (12.5%) malignant. Prediction models using recursive petitioning revealed that CEUS may reduce 31% (95% confidence interval, 23%, 40%) of benign biopsies for masses that are: nonenhancing with circumscribed margins or enhancing with an oval shape and homogeneous enhancement. Quantitative parameters indicated that benign masses had the longest time to peak (P = .078), highest time-to-peak ratio of mass to background (P = .036), lowest peak intensity (P = .021), and smallest difference in peak intensity between the mass and background (P = .079) compared to high-risk and malignant lesions. Conclusions Contrast-enhanced US may be a valuable modality that can be used to predict benign pathologic results of breast masses, thereby reducing the number of biopsies.
Proceedings of the 7th international conference on Autonomic computing

It is our great pleasure to welcome you to the 7th IEEE/ACM International Conference on Autonomic Computing and Communications -- ICAC-2010. Since its inception, ICAC has established a track record of meetings that attract quality technical papers addressing the multiple facets of self-management in computing systems and applications, and that promote synergistic interactions among academia and industry. This year's ICAC continues this tradition -- we are pleased with the organization of a strong, diverse program and the opportunity to host an event that brings together experts in this exciting field. So, first and foremost, we would like to thank the authors and conference attendees for making this year's conference a reality. This year, the program chairs have updated the call for papers to attract a broader set of topics to the conference. The call for papers attracted 66 submissions from Asia, Canada, Europe, and the United States. We opted for a smaller TPC than in past years to foster as much as possible group discussions during the face-to-face meeting -- we would like to thank all members of the program committee for their participation in a rigorous review process, in a fruitful TPC meeting, and in the shepherding of papers. Following on the tradition of past ICAC conferences, the TPC has strived to select a set of excellent and timely papers that represent the state of the art in autonomic computing and cover a range of topics in this cross-disciplinary field. This year, these topics include cloud infrastructures, performance and power management, software architectures, troubleshooting, and quality of service. The technical program features 18 papers in the conference main track, five Industry Session papers, and five posters. The chairs would also like to thank Brent Miller, Michael Nunez, and Thierry Coupaye for the organization of the Industry Session, continuing the ICAC tradition of fostering collaborations between industry and academia. We are privileged to have distinguished keynote speakers who will share their experience and vision also from both academia and industry perspectives. Complementing the main conference program are workshops that cover bio-inspired algorithms (BADS), Grid computing (GMAC), and self-organizing architectures (SOAR), and a Hot Topics in Autonomic Computing session associated with the conference, thanks to the leadership of Omer Rana and Julie McCann.
Contested Space: Activism and Protest

Fueled by social media and activism, the museum world, onsite, online, in galleries and public spaces is being held to account by social movements and causes such as MeToo, the opioid crisis, climate change, environmentalism, women’s rights and LGBT. Museum space has become contested space as increasingly the public more than ever is paying attention to the meaning and impact of the message museums are sending, embedded in collections, exhibitions and programs from education to performances. Museum audiences are envisioning a new type of museum for the 21st century, one that now goes beyond participation and interaction, to having impact and representation in museum identity, and importantly one that demands a new social order of museum values that break down past hierarchies creating a more level playing field, where diverse cultures and media of artistic expression are respected and included. This speaks to the very nature of museum space, experience, and meanings. At the heart of this new phenomena of contested public space, a seeming battleground of ideologies, is the Internet, a new social frontier of rapidly expanding space and number of users. A place we describe as a digital ecosystem connecting physical and digital life, and where a new social order is emerging that is changing human relationships, behaviors and values and where everybody is a player, from large corporations, such as Facebook and Google, to cultural institutions and individuals.
Enabling Microsoft OneDrive Integration with HTCondor

Accessing data from distributed computing is essential in many workflows, but can be complicated for users of cyberinfrastructure. They must perform multiple steps to make data available to distributed computing using unfamiliar tools. Further, most research on data distribution has focused on the efficiency of providing data to computing resources rather than considering the ease of use for distributing data. Creating an easy to use data distribution method can reduce the time researchers spend learning cyberinfrastructure and increase its usefulness. Microsoft OneDrive is a online storage solution providing both file storage and sharing. OneDrive provides many different clients to access data stored in the service. It provides many features that users of cyberinfrastructure could find useful such as automatic synchronization with desktop clients. A barrier to using services such as OneDrive is the credential management necessary to access the service. Recent innovations in HTCondor have allowed the management of OAuth credentials to be handled by the scheduler on the user's behalf. The user no longer has to copy credentials along with the job, HTCondor will handle the acquisition, renewal, and secure transfer of credentials on the user's behalf. In this paper, I will focus on providing an easy to use data distribution method utilizing Microsoft OneDrive. Measuring ease of use is difficult, therefore I will will describe the features and advantages of using OneDrive. Additionally, I will compare it to measurements of data distribution methods currently used on a national cyberinfastructure, the Open Science Grid.
What Drives Upper-Ocean Temperature Variability in Coupled Climate Models and Observations?

AbstractA key question in climate modeling is to what extent sea surface temperature and upper-ocean heat content are driven passively by air–sea heat fluxes, as opposed to forcing by ocean dynamic...
Digital preservation in libraries: preparing for a sustainable future: Edited by Jeremy Myntti and Jessalyn Zoom, Chicago, IL, ALA Editions, 2019, 392 pp., $84.99, ISBN: 978-08389-1713-8

The rapidly evolving landscape of digital preservation requires a constant awareness of current standards, concepts and tools to build a digital preservation program. Myntti and Zoom present an org...
An editor’s-eye view of randomized controlled trials

Abstract What do journals look for when vetting papers that use experimental designs? This piece provides an editor’s perspective on handling manuscripts that incorporate randomized approaches—and explains how to successfully present rigorous research based upon these methodologies. After considering bigger-picture issues like the underlying research questions of randomized controlled trials and their potential contributions, it discusses what information is important to include for adequately and transparently describing the studies themselves. Readers will learn how to prepare articles involving randomization, while gaining insight into the editorial process at World Development and other journals with similar standards.