cssi/SciSciGPT-SciSciNet huggingface dataset:
Trends in Na-Ion Solvation with Alkyl-Carbonate Electrolytes for Sodium-Ion Batteries: Insights from First-Principles Calculations

Classical molecular dynamics (MD) simulations and M06-2X hybrid density functional theory calculations have been performed to investigate the interaction of various nonaqueous organic electrolytes with Na+ ion in rechargeable Na-ion batteries. We evaluate trends in solvation behavior of seven common electrolytes namely pure carbonate solvents (ethylene carbonate (EC), vinylene carbonate (VC), propylene carbonate (PC), butylene carbonate (BC), dimethyl carbonate (DMC), ethyl methyl carbonate (EMC), and diethyl carbonate (DEC)) and four binary mixtures of carbonates (EC:PC, EC:DMC, EC:EMC, and EC:DEC). Thermochemistry calculations for the interaction of pure and binary mixtures of carbonate solvents with Na+ ion, Na+ ion coordinated with carbonate clusters obtained from molecular dynamics simulations, show that the formation of Na-carbonate complexes is exothermic and proceeds favorably. Based on the highest binding energy (ΔEb), enthalpy of solvation (ΔH(sol)), and Gibbs free energy of solvation (ΔG(sol)) ...
Contender: A Resource Modeling Approach for Concurrent Query Performance Prediction

Predicting query performance under concurrency is a difficult task that has many applications in capacity planning, cloud computing, and batch scheduling. We introduce Contender, a new resourcemodeling approach for predicting the concurrent query performance of analytical workloads. Contender’s unique feature is that it can generate effective predictions for both static as well as adhoc or dynamic workloads with low training requirements. These characteristics make Contender a practical solution for real-world deployment. Contender relies on models of hardware resource contention to predict concurrent query performance. It introduces two key metrics, Concurrent Query Intensity (CQI) and Query Sensitivity (QS), to characterize the impact of resource contention on query interactions. CQI models how aggressively concurrent queries will use the shared resources. QS defines how a query’s performance changes as a function of the scarcity of resources. Contender integrates these two metrics to effectively estimate a query’s concurrent execution latency using only linear time sampling of the query mixes. Contender learns from sample query executions (based on known query templates) and uses query plan characteristics to generate latency estimates for previously unseen templates. Our experimental results, obtained from PostgreSQL/TPC-DS, show that Contender’s predictions have an error of 19% for known templates and 25% for new templates, which is competitive with the state-ofthe-art while requiring considerably less training time.
Abstract 2737: Common autoantibodies in ovarian cancer (OvCa) and infertility may define biomarkers for OvCa risk

Background: A 20-year longitudinal study of over 12,000 women shows a higher epidemiologic risk for OvCa and other cancers among women with infertility (Brinton et al, 2005, Epidemiology). In recent studies of an autoimmune etiology for some women with infertility we identified ovarian autoantigens. Several of the autoantigens were also reported as autoantigens in OvCa. Therefore the objective was to determine if there are commonly occurring autoantibodies in sera of women with infertility and OvCa in order to identify a potential risk group that would benefit from closer monitoring and earlier detection of OvCa. Methods: We assessed antibodies to eight recombinant proteins previously identified as OvCa markers or as autoantigens in infertility. Sera (1:100) from women with infertility (n=28), malignant OvCa (n=21), benign ovarian tumors (n=9) and healthy control women without cancer (n=6) were assessed against the antigens (50 ng/well) in standard immunoassays. The antigens included mesothelin, glyceraldehyde-3-phosphate dehydrogenase (GAPDH), protein disulfide-isomerase A3 (PDIA3), Selenium Binding Protein 1 (SBP1), aldehyde dehydrogenase 1A1 (ALDH1), aldehyde dehydrogenase 3A1 (ALDH3), alpha-enolase and vimentin. Positive values were those 2 standard deviations above the mean control optical density value (p Results: Antibodies to individual antigens in infertility recognized mesothelin (57%), GAPDH (43%), vimentin (43%), enolase (29%), PDIA3 (39%), SBP1 (43%), ALDH1 (46%) and ALDH3 (50%). Results were similar in OvCa for antibodies to mesothelin (33%), GAPDH (38%), vimentin (29%), enolase (29%), PDIA3 (33%), SBP1 (24%), ALDH1 (24%) and ALDH3 (38%). Only enolase antibodies (33%) were found in sera of women with benign tumors. The frequency distribution showed that benign tumor sera reacted with 0 or 1 antigen, women with infertility had peaks at 0, 4 or 6-8 antigens and OvCa sera had peaks at 0, and 5-8 antigens. Conclusions and Significance: We have demonstrated antibodies to 8 ovarian autoantigens in sera from a high frequency of women with OvCa or infertility, a group with increased risk for OvCa. This suggests that assaying for antibodies to such antigens could be used for screening risk groups towards early detection of OvCa. Infertility affects over 10% of reproductive age women. These women are at increased risk of developing OvCa based on current epidemiological data and represent a sizable segment of the population. They would benefit from risk assessment and routine screening for early detection of OvCa. Support: JL: NIH R01AI 055060, Ovarian Cancer SPORE (P50CA83636) Development Award, Segal Women9s Cancer Award; IH & JL: NIH R01CA134487 Citation Format: {Authors}. {Abstract title} [abstract]. In: Proceedings of the 101st Annual Meeting of the American Association for Cancer Research; 2010 Apr 17-21; Washington, DC. Philadelphia (PA): AACR; Cancer Res 2010;70(8 Suppl):Abstract nr 2737.
Breeding and Application of New Hybrid Late Rice Combination Xieyouzhong No.1 with Good Quality,High Yield,Disease Resistance and Early Maturing

Xieyouzhong No.1,a new hybrid late indica rice combination,was bred by Jinhua Municipal Institute of Agricultural Sciences in Zhejiang Province and China Institute of Rice Research,its mother parent is CMS line Xieqingzao A,its father parent is restoring line Zhongzu 14.The combination possesses the following characteristics: early maturing,resistance to rice blast,good quality,high and stable yield,high yield of seed production.On February 6th,2010,Xieyouzhong No.1 passed the validation by Zhejiang Provincial Crop Variety Approval Committee.The article describes the selection process,characteristics,cultivation and seed production techniques of Xieyouzhong No.1.
Evolution of stacking faults in substituted nickel hydroxide spherical powders

Abstract Nickel hydroxide spherical powders contain small crystallite sizes and stacking faults that are necessary for electrochemical activity. Stacking faults along the c-axis orientation can be visualized by broadening and angular shifts in the (h0l) diffraction peaks, which are directly correlated to the electrochemical utilization of these materials. Higher ratios of growth-type faults to deformation-type faults have been shown to correlate with metrics of high utilization, even after controlling for the total percentage of stacking faults. Depending on the additives, stacking faults tend to increase with precipitation time, but additives, such as Zn, can affect the energy barriers so that precipitation conditions favor fewer stacking faults with precipitation time. Both Co and Zn suppress the percentage of stacking faults that occur in the materials, but a combination of Co and Zn allows the number of stacking faults to increase with precipitation time. The precipitation process has a significant role in the evolution of stacking faults, which can be further optimized to yield high electrochemical utilization in substituted nickel hydroxide spherical powders.
Specificity and mechanism of mandelamide hydrolase catalysis.

Abstract The best-studied amidase signature (AS) enzyme is probably fatty acid amide hydrolase (FAAH). Closely related to FAAH is mandelamide hydrolase (MAH), whose substrate specificity and mechanism of catalysis are described in this paper. First, we developed a convenient chromogenic substrate, 4-nitrophenylacetamide, for MAH. The lack of reactivity of MAH with the corresponding ethyl ester confirmed the very limited size of the MAH leaving group site. The reactivity of MAH with 4-nitrophenyl acetate and methyl 4-nitrophenyl carbonate, therefore, suggested formation of an “inverse” acyl-enzyme where the small acyl-group occupies the normal leaving group site. We have interpreted the specificity of MAH for phenylacetamide substrates and small leaving groups in terms of its active site structure, using a homology model based on a FAAH crystal structure. The relevant structural elements were compared with those of FAAH. Phenylmethylboronic acid is a potent inhibitor of MAH (K i = 27 nM), presumably because it forms a transition state analogue structure with the enzyme. O-Acyl hydroxamates were not irreversible inactivators of MAH but some were found to be transient inhibitors.
Reliability Criteria Based Reconfigurable Control System Design

Abstract A performance measure for a reconfigurable control system is introduced in the form of an interval between two values of coverage that is to enter the overall system reliability computation. The size of the interval is a reRection of information deficiency. The definition of such coverage depends explicitly on the performance measures of a control module and a diagnostic module. It allows us, in a precise manner, to depict the relationships between the overall system reliability and the performance requirements on these modules. An example is given to show how reliability is functionally related to the values of diagnostic resolution and of control performance threshold.
The Weird, the Small, and the Uncontrollable: Redefining the Frontiers of Computing

Several potential avenues exist for redefining the frontiers of computing through nontraditional paradigms. Although none of these paradigms is currently competitive with CMOS-based technology, they have the potential for cheaper, faster, more robust, and more energy-efficient information processing.
Ipsilateral femur and tibia fractures in pediatric patients: A systematic review.

AIM To better understand how pediatric floating knee injuries are managed after the wide spread use of new orthopaedic technology. METHODS We searched EMBASE, COCHRANE and MEDLINE computerized literature databases from the earliest date available in the databases to February 2017 using the following search term including variants and pleural counterparts: Pediatric floating knee. All studies were thoroughly reviewed by multiple authors. Reference lists from all articles were scrutinized to identify any additional studies of interest. A final database of individual patients was assembled from the literature. Univariate and multivariate statistical tests were applied to the assembled database to assess differences in outcomes. RESULTS The English language literature contains series with a total of 97 pediatric patients who sustained floating knee injuries. Patients averaged 9.3 years of age and were mostly male (73). Approximately 25% of the fractures were open injuries, more tibia (27) than femur (10). Over 75% of the fractures of both the tibia and the femur involved the diaphysis. More than half (52) of the patients were treated non-operatively for both fractures. As a sequela of the injury 32 (33%) patients were left with a limb length discrepancy, 24 (25%) patients had lengthening of the injured limb at follow up, while 8 (8%) had shortening of the affected limb. Infection developed in 9 patients and 3 had premature physeal closure. Younger patients were more likely to be treated non-operatively (P < 0.001) and patients treated with operative intervention had statistically significant shorter hospital length of stays (P = 0.001). CONCLUSION Given the predominance of non-operative management in published studies, the available literature is not clinically relevant since the popularization of internal fixation for pediatric long-bone fractures.
Stochastic Difference Equations with Sociological Applications

For the sake of simplicity, all the variables in all of the examples given in these notes will refer to “the number of people of a certain type in a population with stationary age structure.” Variables (e.g., X5,Y0,Zt) will be written in capitals with a subscript indicating time (measured in years), and constants (e.g., a, b, υ) will be written in lower case letters.
Narrative learning using podcasts in interpersonal communication

ABSTRACTCourse: Interpersonal CommunicationObjective: This semester-long approach utilizes weekly podcasts to engage students in narrative learning. Students evaluate podcast narratives and apply interpersonal communication concepts and theories through structured and unstructured learning activities.
Activation of a Genetic Program for Cell Death

It has been known for many years that a genetic program exists in multicellular organisms for controlled deletion of unwanted cells. This pathway of cell death is most dramatically evident during metamorphosis and embryonic development but also occurs under many other physiological situations such as differentiation and general cell turnover. This pathway is often called programmed cell death but this name has many connotations which may mislead a true definition of the process. Hence, an alternative name, apoptosis, is often used. This word was derived from the Greek meaning “the falling of leaves from a tree or petals from a flower”.1 This definition implies one part of an organism dying for the sake of the survival of the whole organism. To understand both normal and aberrant activation of apoptosis, it is important to realize that every cell has this genetic program to induce “suicide”, but that the program is normally in a repressed state.
Optimization of biventricular pacing via strain dyssynchrony measurements in a paediatric patient

Cardiac resynchronization therapy is increasingly being used in the paediatric population as a tool for managing patients with heart failure. Various non-invasive parameters have been used to optimize the settings on the biventricular pacemaker. We describe implantation of a biventricular pacemaker in a nineteen-month-old child because of intractable heart failure. By analysing a 17-segment model using strain analysis of the left ventricle, we were able to place the left ventricular lead at the latest activated segment. Furthermore, we were able to minimize the dyssynchrony of the left ventricle when evaluating a range of pacemaker settings.
Single-inhaler combination therapy for maintenance and relief of asthma: a new strategy in disease management.

When an adequate standard of asthma control is not achieved with maintenance treatment of inhaled corticosteroids, the addition of a long-acting β2-adrenergic receptor agonist (LABA) bronchodilator is recommended. Using a combination product, salmeterol/fluticasone propionate (Seretide® or Advair®) or budesonide/formoterol (Symbicort®) is preferred for convenience and avoids any risk that LABA might be used as monotherapy. As formoterol has a rapid onset of bronchodilator effect, the budesonide/formoterol combination can be used for both the maintenance and reliever components of asthma treatment (Symbicort SMART®) and this is endorsed as an effective treatment by the Global Initiative for Asthma.
Digital Interactive Lessons In Phonetics And Phonology: Examples From The Portuguese-Speaking World

In this paper we describe the motivation, implementation, content, and assessment of a digital workbook used for the teaching of Portuguese phonetics and phonology, focusing on mid-vowel contrasts and their lexical and sociolinguistic impacts. The digital workbook incorporates multimedia into interactive lessons and exercises that accommodate students with diverse learning styles.
Homozygous TANGO2 Single Nucleotide Variants Presenting with Additional Manifestations Resembling Alternating Hemiplegia of Childhood-Expanding the Phenotype of a Recently Reported Condition.

Case We report a 15-year-old Indian girl born to a consanguineous couple, who presented with epilepsy, developmental delay, neuroregression, and episodes of alternating hemiparesis. In addition, she had one episode of rhabdomyolysis at the age of 7 years. Extensive genetic and metabolic work up through the years was unrevealing. Eventually a trio whole exome sequencing (WES) revealed homozygous single nucleotide variants in TANGO2 gene. Discussion TANGO2 related recurrent metabolic crises with encephalomyopathy and cardiac arrhythmias were described very recently and only 15 cases were reported in literature at the time of writing. Alternating hemiplegia of childhood which was seen in our patient, has not been described in previous patients with TANGO2 mutation, and thereby expands the emerging phenotypic spectrum of this novel entity. This report also reiterates the utility of WES in diagnosing newly recognized neurogenetic conditions.
Psychological mechanisms driving stress resilience in mindfulness training: A randomized controlled trial.

Objective Mindfulness interventions have been shown to reduce stress; however, the mechanisms driving stress resilience effects are not known. Mindfulness interventions aim to teach individuals how to: (a) use attention to monitor present moment experiences; with (b) an attitude of acceptance and equanimity. A randomized controlled dismantling trial (RCT) was conducted to test the prediction that the removal of acceptance skills training would eliminate stress-reduction benefits of a mindfulness intervention. Method This preregistered RCT randomly assigned stressed community adults to 1 of 3 conditions: (a) Monitor and Accept (MA) mindfulness training, a standard 8-week Mindfulness-Based Stress Reduction (MBSR) intervention that provided explicit instruction in developing both monitoring and acceptance skills; (b) Monitor Only (MO) mindfulness training, a well-matched 8-week MBSR intervention that taught monitoring skills only; or (c) No Treatment (NT) control. Stress and nonjudgment were measured using ecological momentary assessment (EMA) for 3 days at baseline and 3 days at postintervention. Results Consistent with predictions, MA participants increased in nonjudgment and decreased in both stress ratings and the proportion of assessments that they reported experiencing feelings of stress in daily life, relative to both MO and NT participants. Conclusions This RCT provides one of the first experimental tests of the mechanisms linking mindfulness interventions with stress resilience. These findings suggest that acceptance skills training may be a necessary active ingredient and support the value of integrating acceptance skills training into stress-reduction interventions. (PsycINFO Database Record (c) 2019 APA, all rights reserved).
Judging government economic performance

The macroeconomic theory of judging contends that when justices on courts of last resort consider cases involving their governments and economic issues their voting behaviour will be affected by th...
Bringing Order out of Chaos: Establishing an Epistatic Relationship between CD33 and TREM2.

TREM2 and CD33 are microglial receptors associated with Alzheimer's disease (AD) risk. In this issue of Neuron, Griciuc et al. (2019) demonstrate opposing effects of CD33 and TREM2 on AD phenotypes, where CD33 deletion promotes neuroprotection in a manner dependent on TREM2.
Successful rechallenge of rituximab following severe rituximab-induced acute thrombocytopenia in a patient with splenic marginal zone lymphoma:

Rituximab-induced acute thrombocytopenia (RIAT) is a relatively rare complication of rituximab treatment that has been infrequently reported in a number of patients with malignant lymphoma. Most commonly encountered in mantle cell lymphoma, the extent to which RIAT occurs in splenic marginal zone lymphoma is unknown. In this report, we describe a case of RIAT in a patient with splenic marginal zone lymphoma. Rituximab was safely rechallenged with increased premedications and slowed infusion rate. While the exact mechanism of this phenomenon has yet to be elucidated, diligent monitoring of platelet counts following rituximab infusion can be considered in high-risk patients to avoid potential adverse events. Split dose rituximab for high-risk patients may provide an alternative approach to improve patient safety.
Does Steroid Use in Transplant Patients Undergoing Bariatric Surgery Independently Impact Outcomes

Abstract Background Corticosteroids have been a mainstay of immunosuppression in patients after solid organ transplantation. Due to deleterious effects, there is a push to minimize steroid use. The impact of corticosteroid use on prior solid organ transplant patients undergoing metabolic and bariatric surgery (MBS) is unknown. The aim of this study was to determine if corticosteroid use independently impacts surgical outcomes after MBS in solid organ transplant patients. Materials and methods A retrospective analysis was performed on patients undergoing sleeve gastrectomy and Roux-en-Y gastric bypass in the 2017 Metabolic and Bariatric Surgery Accreditation Quality and Improvement Project Participant Use File database. Patients with a history of solid organ transplantation were identified and further stratified by corticosteroid use. Univariable and multivariable regression for multiple postoperative outcomes were performed. Results Overall findings are summarized in visual abstract. Of 382 prior solid organ transplant patients, 42% (n = 160) were on corticosteroids. Patients on corticosteroids had significantly higher overall morbidity (16% versus 9%, P Conclusions Solid organ transplant patients undergoing MBS on corticosteroids have a significantly increased rate of overall morbidity (P
On the axial location of Gunn's dots.

Abstract Purpose To determine the axial location of Gunn's dots in the retina. Methods Adaptive optics scanning laser ophthalmoscopy (AOSLO) images and adaptive optics – optical coherence tomography (AO-OCT) volumes were collected from a region where Gunn's dots were found inferior to the optic disc from a subject determined by clinical examination to be a glaucoma suspect. AO-OCT volumes were also collected along the horizontal and vertical meridians from six healthy subjects and one glaucoma subject to identify and document other occurrences of Gunn's dots. AO-OCT volumes were registered in three-dimensions and averaged. Gunn's dots were segmented, and their volume, area, and diameter were measured. Results All Gunn's dots imaged in this study from all subjects were confined to the inner limiting membrane, neither extending into the vitreous nor into the nerve fiber layer. The size of the dots was highly variable. The measured volume, area, and diameter (mean ± standard deviation) were 1119.9 ± 590.9 μm3, 220.2 ± 105.5 μm2, and 14.3 ± 3.1 μm, the latter within the range as previously published reports. Conclusions Based upon evidence from this study and others, Gunn's dots are not thought to be Muller cell end-feet or hyalocytes. We hypothesize that they are related to microglia, either as the by-product of their phagocytosis function, or are actual dead ameboid-shaped microglia who have fulfilled their scavenger role in retinal pathology. Further studies are needed in diseased eyes to determine if they have predictive value.
Fact or Fiction? Practice on a Simulator is Not Required to Pass the Fundamentals of Endoscopic Surgery (FES)TM Skills Exam

Purpose Initial work on the validity evidence used to support the Fundamentals of Endoscopic Surgery (FES) performance exam as a measure of technical competency showed a strong relationship to clinical experience. Despite this evidence, there is a perception among some program directors that the exam cannot be successfully passed without practice on a simulator. We assess the validity of this perception. Methods Deidentified data from the initial FES skills examination (prior to the 2014 FEC requirement) was reviewed, and 335 unique participants with reported simulation experience demographics were identified. Self reported data analyzed included gender, total clinical endoscopy procedure experience (1-150, 151-300, >300), and endoscopy simulator training hours (0, 1-5, 6-10, 11-20, >20). Final FES skills exam scores, and pass/fail designations for each participant were reported by the FES program staff. Continuous variables were compared between groups using one-way analysis of variance with post-hoc analysis where appropriate. Categorical variables were compared using Pearson Chi-Squared. The effect of variables on pass rate was assessed using univariate and multivariate logistic regression. Results Simulation training experience (SE) was categorically reported in hours(n,%): 0 (98, 29%), 1-5 (135, 40%), 6-10 (52, 16%), 11-20 (24, 7%), and >20 (26, 8%). Clinical endoscopy experience (CE), reported categorically as total cases performed (n,%), was available for 323 of 355 identified participants: 1-150 (126, 39%), 151-300 (99, 31%), >300 (98, 30%). There was no statistically discernible differences in mean FES total or task scores across the SE groups (total score 0:72 ± 15, 1-5:72 ± 13, 6-10:71 ± 14, 11-20:71 ± 16, 20:78 ± 13; p = 0.28), while both total score and task scores were discernibly higher in the more experienced CE groups (>151) compared to the least experienced group (total score; 300:77 ± 14; p 20: 85%; x2 = 2.5, p = 0.6), but there was a strong relationship between clinical experience and pass rate ( 300: 89%; x2 = 15.8, p Conclusions FES skills examination data collected on participants completing the examination before the FEC requirement shows no demonstrable relationship with self-reported training experience on a simulator but confirms a strong relationship with clinical endoscopy experience. This lends further evidence to the validity of the FES exam as a marker of clinical endoscopic skill.
Institutional trust, beliefs, and evaluation of regulations, and management of chronic wasting disease (CWD)

Institutional trust and perceptions of regulatory efficacy can affect support for management. This study examined how institutional trust, specific trust related to information/management, and supp...
Towards a robust out-of-the-box neural network model for genomic data

The accurate prediction of biological features from genomic data is paramount for precision medicine, sustainable agriculture and climate change research. For decades, neural network models have been widely popular in fields like computer vision, astrophysics and targeted marketing given their prediction accuracy and their robust performance under big data settings. Yet neural network models have not made a successful transition into the medical and biological world due to the ubiquitous characteristics of biological data such as modest sample sizes, sparsity, and extreme heterogeneity. Results: Here, we investigate the robustness, generalization potential and prediction accuracy of widely used convolutional neural network and natural language processing models with a variety of heterogeneous genomic datasets. While the perspective of a robust out-of-the-box neural network model is out of reach, we identify certain model characteristics that translate well across datasets and could serve as a baseline model for translational researchers. Here, we investigate the robustness, generalization potential and prediction accuracy of widely used convolutional neural network and natural language processing models with a variety of heterogeneous genomic datasets. While the perspective of a robust out-of-the-box neural network model is out of reach, we identify certain model characteristics that translate well across datasets and could serve as a baseline model for translational researchers.
Alternative Lengthening of Telomeres is a Self-Perpetuating Process in ALT-Associated PML Bodies

Alternative lengthening of telomeres (ALT) is mediated by break-induced replication (BIR), but how BIR is regulated at telomeres is poorly understood. Here, we show that telomeric BIR is a self-perpetuating process. By tethering PML-IV to telomeres, we induced telomere clustering in ALT-associated PML bodies (APBs) and a POLD3-dependent ATR response at telomeres, showing that BIR generates replication stress. Ablation of BLM helicase activity in APBs abolishes telomere synthesis but causes multiple chromosome bridges between telomeres, revealing a function of BLM in processing inter-telomere BIR intermediates. Interestingly, the accumulation of BLM in APBs requires its own helicase activity and POLD3, suggesting that BIR triggers a feedforward loop to further recruit BLM. Enhancing BIR induces PIAS4-mediated TRF2 SUMOylation, and PIAS4 loss deprives APBs of repair proteins and compromises ALT telomere synthesis. Thus, a BLM-driven and PIAS4-mediated feedforward loop operates in APBs to perpetuate BIR, providing a critical mechanism to extend ALT telomeres.
Off-Shell Amplitudes

While the previous chapter was purely geometrical, this one makes contact with string theory through the worldsheet CFT. We continue the description of \(\mathcal P_{g,n}\) by constructing p-forms. The reason why we need to consider the CFT is that ghosts are necessary to build the p-forms: this can be understood from Chap. 2, where we found that the ghosts must be interpreted as part of the measure on the moduli space. Then, we build the off-shell amplitudes and discuss some properties.
Perinatal telemedicine at lower-level birthing hospitals in Maryland. Lessons learned from a landscape analysis.

Background To assess the current perinatal telemedicine (PTM) landscape and inform the design and implementation of a PTM network linking Level I/II birthing hospitals with the two Level IV hospitals in Maryland to improve access to maternal-fetal medicine (MFM) specialist care. Methods Qualitative in-depth interviews were conducted with 24 clinicians and telemedicine experts during July-September 2020. We obtained data on 12 Level I/II and both Level IV hospitals. Results Less than half of Level I/II hospitals currently offer obstetric services through telemedicine, and both Level IV hospitals have interest and technical capacity to support implementation of a PTM network in Maryland. The Covid-19 related shift to telehealth and telemedicine was identified as a facilitator for such PTM programs. Perceived barriers to provider adoption of PTM services and network in Maryland included hospital leadership buy-in, information technology (IT) literacy, and patient triage complexities. Perceived barriers to patient adoption of PTM were access to technology, IT literacy, and language. Key benefits of PTM services included overall improved patient access, convenience, cost-savings, and safety during the COVID-19 pandemic. Influential factors for implementing a PTM network in Maryland included buy-in and approval from hospital and health system administration, a streamlined telehealth platform allowing for electronic medical record integration and interoperability, program funding, and sustainability. Conclusions Gaps in availability of MFM care at Level I/II birth hospitals call for expanded telemedicine programming to improve high-risk patients' access to specialty obstetric care and support the development of a PTM network in Maryland.
Multistationarity in cyclic sequestration-transmutation networks

We consider a natural class of reaction networks which consist of reactions where either two species can inactivate each other (i.e., sequestration), or some species can be transformed into another (i.e., transmutation), in a way that gives rise to a feedback cycle. We completely characterize the capacity of multistationarity of these networks. This is especially interesting because such networks provide simple examples of "atoms of multistationarity", i.e., minimal networks that can give rise to multiple positive steady states
Post-gastrointestinal endoscopy complications in patients with obstructive sleep apnea or at high risk for sleep apnea: a systematic review and meta-analysis

Obstructive sleep apnea (OSA) is becoming increasingly more prevalent with the rise in obesity. Complications from gastrointestinal (GI) endoscopy in this patient population have been reported in several studies, but the modest complication rates from these procedures make it difficult to come to definitive conclusions based on single studies. The objective of our study was to systematically review these studies reporting the incidence of post-procedure complications in patients with OSA undergoing endoscopy to determine whether the presence of OSA increases post-procedure complications. We conducted a systematic review using the Cochrane Collaboration Methodology. We searched Medline via Ovid, PubMed, Embase, and Evidence Based Medicine Reviews databases from 1950 to August 2013. We rated the quality of evidence for each outcome using the Grading of Recommendations Assessment, Development, and Evaluation (GRADE) methodology. Meta-analysis was done using Review Manager Version 5.0.20. Our search resulted in seven eligible studies. There was no significant association between diagnosis of OSA and post-GI endoscopy complications including hypoxemia, respiratory distress, variations in blood pressure or heart rate, bradypnea, or need for significant interventions. Subgroup analysis based on the type of GI endoscopy or the type of anesthesia used did not show any significant associations either. Obstructive sleep apnea patients and/or patients at high risk for obstructive sleep apnea do not appear to be at increased risk of adverse outcomes from GI endoscopy.
Symptom Management for Cancer Patients

서론 최근 노령인구 증가 등으로 암발생이 급격히 증가하고 있다. 국가암등록 통계자료에 의하면 2009년 한 해동안 192,561명의 암환자가 발생하였다. 이는 2008년에 비해 암발생률이 6.7% 증가한 수치이다. 암치료 기술의 발달로 암생존률 또한 급격히 증가하고 있다. 1993∼1995년 암발생자의 5년 생존율이 41.2%였던데 비해, 2005∼2009년 암발생자의 5년 생존율은 62.0%로 증가하였다(1). 이처럼 암발생의 증가와 암치료 후 생존율의 증가로 인해 10년 내 암을 한번이라도 진단 받은 적이 있는 암환자의 유병률이 2010년 1월 1일 기준으로 808,503명에 이른다(1). 유병 암환자들 중에는 현재 치료중인 환자도 포함되어 있고, 치료가 끝나고 건강을 되찾은 생존자도 있으며, 전이나 재발 등으로 치료가 어려워진 상태에 이른 말기암환자도 포함되어 있다. 일단 암을 진단받으면 인생에서 가장 큰 어려움을 겪게 된다. 종양이 치료가 되든, 치료가 어려운 상태로 진행하든 간에 암환자는 기나긴 어려운 여정을 지내야 한다. 암이라는 질환이 생명을 위협하기 때문에 암진단 자체가 커다란 공포를 몰고 온다. 이로 인해 암환자들은 정신적인 스트레스를 받고 불안과 우울에 사로 잡힌다. 암이 진행하여 조직을 침범하게 되면 이로 인해 통증, 부종, 호흡장애, 장폐색 등 여러 가지 신체적 증상을 일으키고, 이로 인해 암환자들은 고통을 받게 된다. 종양이 성공적으로 제거되고 치료되더라도, 보이지 않는 암세포가 다시 자라나 재발할 가능성이 있기 때문에 보통 5년이상 정기적으로 재발 여부를 검사하기 위하여 병원을 다녀야 한다. 이 과정 동안 암환자는 불안과 우울 등의 정신 심리적인 고통을 겪고, 이와 연관되어 나타나는 소화기능장애, 성기능장애 등 다양한 신체적 증상을 겪기도 한다. 보통 수개월 이상 지속되는 암치료과정에서 종양이 직접 일으키는 문제와는 별개로 암치료의 부작용으로 인해 고통을 받게되고, 이러한 부작용 중 일부는 치료 후 상당기간이 지난 후까지 암환자의 건강과 삶에 영향을 미친다. 또한 암치료를 하면서 암환자들은 직장을 그만두기도 하고, 치료비 등으로 경제적 어려움을 겪고, 가족들과의 갈등을 겪기도 한다(2). 이처럼 암환자들이 암진단 이후에 겪게 되는 고통은 종양자체가 일으키는 문제에 국한되지 않고, 치료과정에서 또 치료 후에 겪게 되는 다양한 정신신체적 증상과 사회경제적 어려움을 포함한다. 암환자 치료의 일차적인 목표는 물론 생명을 위협하는 종양을 효과적으로 제거하거나 진행을 억제하는 것이다. 암치료 기술이 급격히 발전하면서 암생존 기간이 늘어나고 있어 이러한 치료 목표는 어느 정도 달성하고 있는 것처럼 보인다. 하지만 생존기간이 늘이는 만큼이나 살아가는 동안의 삶의 질을 높이는 것도 중요한 문제가 되고 있다. 예를 들면 뼈전이가 일어난 암환자의 경우 심한 통증과 함께 활동 제한, 빈혈의 진행과 피로 등의 고통을 겪게 된다. 뼈는 생명과 직접 연관된 기관(vital organ)이 아니기 때문에 뼈전이가 바로 임종을 예견하지 않는다. 특히 전
Design, The "Straw" Missing From the "Bricks" of IS Curricula

As punishment in the biblical story of Moses the slaves were told they had to make bricks without straw. This was impossible because bricks made without straw had the appearance of strength and function, but could not withstand the proof of actual use. The slaves' punishment was therefore not only to make bricks, but also to find the straw on their own with which to make them. In this day and age it would seem that many of our Information Systems curricula ask students to learn to make systems without teaching them about design. We are good at teaching students how to make software systems that do things but not so good at teaching students how one way of doing things in a system design is better than another. In this essay I consider the role of teaching systems design in preparing an IS professional and the forces that have come into play over the history of computing that have in many cases frozen out the study of design from the IS curricula.
The immunomodulatory role of glycoprotein nonmelanoma clone B (GPNMB) in macrophage polarization in diabetes (IRC10P.465)

Diabetes is associated with a low-grade chronic inflammation, which has been linked with macrophage dysfunctions manifested by exaggerated pro-inflammatory M1 response and attenuated M2 response. The objective of this study is to validate glycoprotein nonmelanoma clone B (GPNMB) as an immunomodulatory factor that can regulate polarization of macrophages from diabetic mice. In an in vitro study of macrophages polarization, we have observed that GPNMB expression in macrophages from wild-type mice negatively correlates with the gene expression levels of the pro-inflammatory cytokines in which macrophages were induced to polarize into the inflammatory (M1: treatment with 100 ng/mL LPS and 20 ng/mL IFN gamma) or regenerative (M2: treatment with 20 ng/mL interleukin 4) phenotypes. In addition, we have found that polarized macrophages from db/db mice exhibited higher M1 markers and reduced M2 markers as compared with litter mate control mice. More importantly, the exogenous treatment of recombinant GPNMB protein (100ng/mL) could significantly attenuate the level of CD86 expression in M1 macrophages, upregulate CD206 expression in M2 macrophages, and increase the phagocytosis of apoptotic neutrophils by M2 macrophages from db/db mice, with responses that were comparable to those of control mice. Taken together, those results support that GPNMB could act as an immunomodulatory factor that can rescue aberrant functions of macrophages in diabetes.
On the Use Of Concept Maps As An Assessment Tool in Science: What We Have Learned so Far

En este articulo se describe el uso de mapas conceptuales como instrumento de evaluacion para medir la organizacion del conocimiento proposicional (declarativo) del aprovechamiento en ciencias. Como instrumento de evaluacion, un mapa conceptual esta constituido por una tarea que invita al estudiante a representar la organizacion de su conocimiento en un topico especifico; un formato de respuesta; y una sistema de calificacion. Un problema de interpretacion de constructo que plantea el uso de mapas conceptuales consiste en que distintos tipos de tarea, formato de respuesta, y sistema de calificacion dan como resultado diversas tecnicas de mapas conceptuales que pueden producir en los estudiantes distintas formas de representacion del conocimiento. Este articulo presenta un panorama de la investigacion de los mapas conceptuales como instrumento evaluativo. Se describen brevemente algunos estudios que han evaluado la confiabilidad y la validez de los mapas conceptuales y se presenta una sintesis de lo que hasta ahora se sabe de este tipo de instrumento.
Motivation in Small Groups

Distinguished sociologists or beatniks? From whom does a particular individual desire recognition? It is the small group of fairly close associates, says Professor Volkart, that is basically instrumental in motivating changes in behavior.
Deletion of the Gene Encoding the Cyclin-Dependent Protein Kinase Pho85 Alters Glycogen Metabolism in Saccharomyces cerevisiae

Pho85, a protein kinase with significant homology to the cyclin-dependent kinase, Cdc28, has been shown to function in repression of transcription of acid phosphatase (APase, encoded by PHO5) in high phosphate (Pi) medium, as well as in regulation of the cell cycle at G1/S. We describe several unique phenotypes associated with the deletion of the PHO85 gene including growth defects on a variety of carbon sources and hyperaccumulation of glycogen in rich medium high in Pi. Hyperaccumulation of glycogen in the pho85 strains is independent of other APase regulatory molecules and is not signaled through Snf1 kinase. However, constitutive activation of cAPK suppresses the hyperaccumulation of glycogen in a pho85 mutant. Mutation of the type-1 protein phosphatase encoded by GLC7 only partially suppresses the glycogen phenotype of the pho85 mutant. Additionally, strains containing a deletion of the PHO85 gene show an increase in expression of GSY2. This work provides evidence that Pho85 has functions in addition to transcriptional regulation of APase and cell-cycle progression including the regulation of glycogen levels in the cell and may provide a link between the nutritional state of the cell and these growth related responses.
Protection of mice against fatal pneumococcal challenge by immunization with pneumococcal surface adhesin A (PsaA)

Pneumococcal surface adhesin A (PsaA) is a 37-kDa surface protein present on Streptococcus pneumoniae having significant homology with fimbrial adhesion proteins. Immunization of CBA/CaHNJ Xid mice with PsaA using either complete Freund's or TiterMax adjuvants significantly protected mice against heterologous intravenous challenge with type 3 pneumococcal strain WU2 at doses up to 45 times the LD50. The results indicate that PsaA warrants further evaluation as a vaccine candidate for human pneumococcal disease.
Graph-based stochastic control with constraints: A unified approach with perfect and imperfect measurements

This paper is concerned with the problem of stochastic optimal control (possibly with imperfect measurements) in the presence of constraints. We propose a computationally tractable framework to address this problem. The method lends itself to sampling-based methods where we construct a graph in the state space of the problem, on which a Dynamic Programming (DP) is solved and a closed-loop feedback policy is computed. The constraints are seamlessly incorporated to the control policy selection by including their effect on the transition probabilities of the graph edges. We present a unified framework that is applicable both in the state space (with perfect measurements) and in the information space (with imperfect measurements).
Effects of central alpha-MSH injections on performance in a cued discrimination task.

Abstract Alpha-MSH has been implicated in changing attention behavior following peripheral injections, but not brain sites were studied. In the present report, alpha-MSH was injected directly into specific sites in the medial anterior hypothalamic/preoptic area (MAHPOA) while measuring performance in a visually cued discrimination task. Alpha-MSH injections resulted in reduced errors, indicated by decreased responding during noncued intervals, but no change in responding to correct cues. The improved error rate was consistent with attentional changes in a variety of paradigms. Attentional and motivational parameters were differentiated. The injected alpha-MSH appears to act on an inhibitory component of an attentional mechanism.
Risk Communication: A New Dimension in Sport‐Fisheries Management

Abstract The presence of chemical contaminants in sport-caught fish has added a new dimension to the responsibility of fishery managers charged with providing angling opportunities while protecting human health. Issuing fish-consumption health advisories, either alone or in conjunction with a public health agency, is one appropriate management strategy. Risk communication theory provides a framework for developing and distributing advisories. This paper presents a model of the risk communication process applied to sport-fishery management, based on empirical evidence about angler knowledge of and behavior toward chemical contaminant hazards. The model specifies characteristics of the senders and receivers of the risk message, as well as the message itself and distribution mechanisms used. The model may be used to develop effective sport-fish management programs to achieve specific objectives.
Shifting Paradigms The Valuing of Personal Knowledge, Wisdom, and Other Invisible Processes in Organizations

Where should the field of management inquiry be heading? What should be the role of "personal knowledge" in management? How should management scholars and teachers attempt to bridge the currently p...
Parametric Empirical Bayes Inference: Theory and Applications

Abstract This article reviews the state of multiparameter shrinkage estimators with emphasis on the empirical Bayes viewpoint, particularly in the case of parametric prior distributions. Some successful applications of major importance are considered. Recent results concerning estimates of error and confidence intervals are described and illustrated with data.
Asymptotic Properties of Zeros of Hypergeometric Polynomials

In a paper by K. Driver and P. Duren (1999, Numer. Algorithms21, 147-156) a theorem of Borwein and Chen was used to show that for each [email protected]?N the zeros of the hypergeometric polynomials F(-n, kn+1; kn+2; z) cluster on the loop of the lemniscate {z:|z^k(1-z)|=k^k/(k+1)^k^+^1}, with Re{z}>k/(k+1) as n->~. We now supply a direct proof which generalizes this result to arbitrary k>0, while showing that every point of the curve is a cluster point of zeros. Examples generated by computer graphics suggest some finer asymptotic properties of the zeros.
3D SAR approach to IF SAR processing

Interferometric SAR (IFSAR) can be shown to be a special case of 3-D SAR image formation. In fact, traditional IFSAR processing results in the equivalent of merely a super- resolved, under-sampled, 3-D SAR image. However, when approached as a 3-D SAR problem, a number of IFSAR properties and anomalies are easily explained. For example, IFSAR decorrelation with height is merely ordinary migration in 3-D SAR. Consequently, treating IFSAR as a 3-D SAR problem allows insight and development of proper motion compensation techniques and image formation operations to facilitate optimal height estimation. Furthermore, multiple antenna phase centers and baselines are easily incorporated into this formulation, providing essentially a sparse array in the elevation dimension. This paper shows the Polar Format image formation algorithm extended to 3 dimensions, and then proceeds to apply it to the IFSAR collection geometry. This suggests a more optimal reordering of the traditional IFSAR processing steps.
Hepatitis B vaccination in human immunodeficiency virus-infected adults receiving hemodialysis

Hepatitis B vaccination in human immunodeficiency virus-infected adults receiving hemodialysis. Background The Centers for Disease Control and Prevention (CDC) recommends hepatitis B virus (HBV) immunization for all hemodialysis (HD) patients because they are at high risk of infection. Several studies have shown that the development of protective antibody titers after HBV vaccination is much lower in HD patients. We hypothesized that human immunodeficiency virus (HIV) infection in patients with end-stage renal disease (ESRD) would further impair the immune response to hepatitis B vaccination. Methods We performed a retrospective cohort study of patients undergoing long-term hemodialysis from 1990 to 2002 at the United States-based dialysis facilities of Gambro Corporation, North America. The response rate defined as an increase in anti-HBs levels ≥10 mIU/L after a month of the third dose of HBV vaccination was determined in HIV-infected and a randomly selected group of ESRD patients. The demographic information, laboratory data, and hepatitis B surface antibody (anti-HBs) titers were recorded from the Gambro Corporation database on these patients. Results Of the 347 adult HIV ESRD patients, 116 received three doses of recombinant hepatitis B vaccination. Seventy percent were male, and the majority (86%) were black. Of the 116 patients who received three doses of HBV vaccination, 62 (53.4%) developed protective antibody titers. This was comparable to the response rate of 50.4% in the randomly selected 220 non-HIV hemodialysis patients. Among HIV ESRD patients, the mean hemoglobin (Hgb) was higher in patients who developed protective antibody titers (Hgb 11.61 ± 2 vs. 10.55 ± 1.86, P value Conclusion Hepatitis B vaccination should be offered to all HIV-infected ESRD patients because over half of the patients with HIV and ESRD can develop protective antibodies.