cssi/SciSciGPT-SciSciNet huggingface dataset:
DNA Topoisomerases: Essential Enzymes and Lethal Targets

INTRODUCTION In 1971, Wang (1) discovered the first DNA topoisomerase in Escherichia coli. The enzyme (E. coli DNA topoisomerase I, or w protein) catalyzed relaxation of negatively supercoiled DNA in the absence of any energy cofactor (1). Wang proposed that this enzyme also catalyzed transient nicking of the DNA double helix and possessed both DNase and ligase activity in one polypeptide (1). The lack of any energy cofactor for the reaction also led Wang to the proposal that the enzyme may form a high-energy covalent bond between itself and the transiently broken DNA phosphodiester bond (1). Both of these predictions have turned out to be correct (2). Since the discovery of E. coli topoisomerase I, investigators have isolated many other DNA topoisomerases from both prokaryotes and eukaryotes. In 1972, Champoux & Dulbecco isolated an enzyme with activity similar to that of E. coli topoisomerase I from mouse embryo cells (3). In 1976, Gellert and his colleagues identified an enzyme activity opposing E. coli DNA topoisomerase I (4). They demonstrated that this enzyme (E. coli DNA topoisomerase II, or gyrase) catalyzed the conversion of relaxed DNA into negatively supercoiled DNA in a reaction requiring ATP hydrolysis (4). These two opposing activities are important for maintaining the super­ helical state of the chromosomal DNA during various DNA transactions (5-8). In 1979, Liu et al (9) isolated an enzyme from bacteriophage
The deubiquitinase activity of A20 is dispensable for NF‐κB signaling

A20 has been suggested to limit NF-κB activation by removing regulatory ubiquitin chains from ubiquitinated substrates. A20 is a ubiquitin-editing enzyme that removes K63-linked ubiquitin chains from adaptor proteins, such as RIP1, and then conjugates them to K48-linked polyubiquitin chains to trigger proteasomal degradation. To determine the role of the deubiquitinase function of A20 in downregulating NF-κB signaling, we have generated a knock-in mouse that lacks the deubiquitinase function of A20 (A20-OTU mice). These mice are normal and have no signs of inflammation, have normal proportions of B, T, dendritic, and myeloid cells, respond normally to LPS and TNF, and undergo normal NF-κB activation. Our results thus indicate that the deubiquitinase activity of A20 is dispensable for normal NF-κB signaling.
On-Demand Anonymous Routing with Distance Vector Protecting Traffic Privacy in Wireless Multi-hop Networks

Because of easy accessible medium in wireless networks, use of these wireless networks in military applications poses several security issues. Likewise, in the business field, despite the emerging static wireless Internet access, the same security issues remains. On example is the passive attack in which attackers attempt to overhear network communications from the outside. Confidentiality can be further divided into two categories, namely, data confidentiality and traffic confidentiality. In this paper, for improving traffic confidentiality, we propose two anonymous routing algorithms, called randomized routing algorithm and probabilistic penalty-based routing algorithm. Both algorithms aim to differentiate routing paths to the same destination enhancing anonymity of the network traffic. We provide simulation results and demonstrate how much these two algorithm disperse routing paths in a network.
Minimal change disease with IgM+ immunofluorescence: a subtype of nephrotic syndrome

Immunoglobulin (Ig) M nephropathy is defined by electron-dense mesangial deposits and mesangial IgM visible by immunofluorescence (IF) without other histopathologic and immunofluorescent microscopic abnormalities. Certain patients have only immuno-positive (IgM+) IF. Children presenting with steroid-dependent or steroid-resistant nephrotic syndrome have a high prevalence of IgM+ IF with or without electron-dense deposits. We reviewed the clinical course of children with steroid-dependent or steroid-resistant nephrotic syndrome who underwent renal biopsy at Texas Children‘s Hospital from 1989 to 2006 to further characterize IgM+ IF in children with nephrotic syndrome. Of the 55 children with steroid-resistant or -dependent minimal change disease (MCD), 23 had IgM+ IF. Of these 23 children, 61% had microscopic hematuria at presentation, 48% (11/23) were steroid-dependent, and 48% (11/23) steroid-resistant (one underwent biopsy prior to steroid therapy). We compared the efficacy of adjuvant treatment with cyclophosphamide and cyclosporine: 18% initially treated with cyclophosphamide obtained remission, while 55% had no response; 83% obtained subsequent remission with cyclosporine. Of those initially treated with cyclosporine, 88% obtained complete or partial remission. IgM+ IF may be surrogate marker for the severity of MCD. Based on our results, children with MCD and IgM+ IF have a better response to cyclosporine than cyclophosphamide.
A Graphic Method for Showing the Polarization History of a Pc1 Micropulsation Event

Essentially the entire polarization and amplitude history of certain micropulsation events recorded on magnetic tape can be presented in graphic visual form on permanent film records by the method described. Moving-film photography of a Lissajous figure swept across an oscilloscope screen results in a continuous cycle by cycle presentation of the polarization ellipse on 35-mm film in raster form, with each line of the raster synchronized to a time base on the tape.
Aquatic herbicide exposure increases salamander desiccation risk eight months later in a terrestrial environment

Contaminants and climate change may be factors in amphibian declines. However, few studies have explored their joint impacts on postmetamorphic amphibians, a life stage of great importance to amphibian population dynamics. Here, we examine the effects of premetamorphic exposure (mean exposure of 64 d) to ecologically relevant concentrations of the globally common herbicide atrazine (0, 4, 40, 400 mg/L) on the behavior and water retention of lone and grouped postmetamorphic, streamside salamanders, Ambystoma barbouri. Salamanders exposed to $40 mg/L of atrazine exhibited greater activity, fewer water-conserving behaviors, and accelerated water loss four and eight months after exposure compared to controls. No recovery from atrazine exposure was detected and its effects were independent of the presence of conspecifics. These results are consistent with the hypothesis that adverse climatic conditions and contaminants can interact to harm post-metamorphic amphibians; however, they suggest that these two stressors need not be experienced simultaneously to do so. These results emphasize the importance of considering both latent and cumulative effects of temporally linked stressors in ecotoxicology. Keywords—Amphibian declines Climate Ontogeny Pesticide Post-exposure effects
A Dynamical Phase Transition in an Infinite Particle System

The local equilibrium picture of the time evolution of a gas may have to be modified in the presence of shocks in order to admit statistical mixtures of pure states in the hydrodynamic description. An example drawn from a stochastic many-particle model (asymmetric zero-range model) is described.
Cuba under the Platt Amendment, 1902-1934

Choice 1987 Outstanding Academic Book This book examines the early years of the Cuban Republic, launched in 1902 after the war with Spain. Although no longer a colony, the country was still hobbled by continuing dependence on and exploitation from a foreign power. Perez shows how U.S. armed intervention in Cuba in 1898 and subsequent military occupation revitalized elements of the colonial system that would serve imperialist interests during independence. The concessions of the Platt Amendment in 1903 became the principal instrument for U.S. expansion in Cuba. The U.S. then gained control over resources and markets."
Bibliotherapy to decrease stress and anxiety and increase resilience and mindfulness: A pilot trial

Introduction Interventions to decrease stress and enhance resiliency and mindfulness are more likely to be widely implemented if they can be offered without the need for in-person training. The purpose of this study was to assess effectiveness of a self-directed Stress Management and Resiliency Training (SMART) program delivered using only written material for improving stress, resiliency, and mindfulness. Methods A total of 37 employees at a large medical center were recruited and given written material on the SMART program. Subjects were instructed to practice the skills presented in the written materials without any additional training. The skills included education about the neuropsychology of stress and resilience, training attention to focus in the present moment, and refining interpretations. Primary outcome measures assessed resilience, perceived stress, anxiety, and quality of life. Results Out of 37 employees, 34 (89%) enrolled subjects completed the study and provided the baseline and follow-up data. A statistically significant improvement in perceived stress, resilience, mindfulness, anxiety, and quality of life was observed at 12 weeks. Conclusion This study demonstrated that a brief, self-directed program to decrease stress and enhance resilience and mindfulness provided excellent short-term effectiveness for enhancing resilience, mindfulness and quality of life, and decreasing stress and anxiety.
Don't just stare at me!

Communication is more effective and persuasive when participants establish rapport. Tickle-Degnen and Rosenthal [57] argue rapport arises when participants exhibit mutual attentiveness, positivity and coordination. In this paper, we investigate how these factors relate to perceptions of rapport when users interact via avatars in virtual worlds. In this study, participants told a story to what they believed was the avatar of another participant. In fact, the avatar was a computer program that systematically manipulated levels of attentiveness, positivity and coordination. In contrast to Tickel-Degnen and Rosenthal's findings, high-levels of mutual attentiveness alone can dramatically lower perceptions of rapport in avatar communication. Indeed, an agent that attempted to maximize mutual attention performed as poorly as an agent that was designed to convey boredom. Adding positivity and coordination to mutual attentiveness, on the other hand, greatly improved rapport. This work unveils the dependencies between components of rapport and informs the design of agents and avatars in computer mediated communication.
A Case Study on the Seismic Protection of Equipment Using Lead-Rubber Bearings

Applications of seismic isolation for essential equipment and components are limited and experimental evidence on the effectiveness of seismic isolation system for protection of equipment in multistory buildings is lacking. The paper includes the developments of experimental studies to assess the effectiveness of lead-rubber isolated platform for the seismic protection of simulated equipment under both horizontal and vertical floor seismic excitations. A scaled earthquake testing program includes a variety of floor accelerations of multistory buildings. A lead damper was introduced into the platform to achieve additional energy dissipation in the system. This paper presents: (1) a summary of the experimental settings of earthquake simulation tests; (2) sample of experimental results; and (3) a discussion on the effectiveness of lead formation to increase the energy dissipation capacity of the isolation platform.
The State I'm in: Hubert Humphrey, Jesse Ventura, Bob Dylan, Garrison Keillor, and Me

Despite being a state mandated requirement for elementary, secondary, and even some college students—and therefore, a teaching requirement for many historians—state history as a field has become historiographically inert. In this essay, I describe how I am trying to reimagine and rethink the genre, focusing on Minnesota.
Analysis on Equivalence Between UHF Discharge Signals Caused by Voltage Pulses Artificially Injected Into GIS and That Caused by Actual Partial Discharge Signals Inside GIS

It is the key procedure for on-site calibration of the sensitivity of(ultra-high-frequency) UHF test system by artificially injecting the voltage pulse into GIS, which is equivalent to the partial discharge(PD) inside the GIS. The distribution differences of time-domain amplitudes and frequency spectrum of UHF signals caused by artificial voltage pulse and actual PD inside the GIS are researched by experiments. A PD testing platform based on 220 kV GIS equipments is constructed and inside the cavity near the outgoing line the UHV electromagnetic waves caused by artificial voltage pulses and PD defects are transmitted respectively and the UHF signals are received by four disc antennae fixed on typical positions. The amplitudes of UHF signals at different positions are measured and the attenuation degrees of UHF signals caused by artificial voltage pulses and PD signals are contrasted. Applying Fourier transform to signal waves, the frequency spectrum distributions of the two kinds of UHF signals are contrasted. Research results show that the UHF signal caused by artificial voltage pulse and passed through the circuit breaker is attenuated a little bit more than the UHF signals caused by PD; the frequency spectrum distribution of the UHF signal caused by artificial voltage pulse is close to that of the UHF signal caused by PD, besides, the rising time of the voltage waveform of artificial voltage pulse varies within the range from 0.3ns to 1ns and it does not influence the frequency spectrum distribution of UHF electromagnetic wave. The obtained research results are available for reference to the on-site calibration of sensitivity of UHF test system.
Analysis and comprehensive evaluation based on managers' quotient

Aiming at the managers of the enterprises, this paper discusses the capabilities that a manager should have from a new angle of view, including such factors as intelligence quotient, emotional quotient, adversity quotient and mental quotient. And on the basis of these factors we establish a 360 degree model and a fuzzy evaluation model to examine managers, making the evaluation of the managers more standardized and easy to generalize.
Research note on racially based audience-centered anxiety.

The audience-centered explanation of anxiety posits that speakers experience significant anxiety about public speaking when they believe that important racial and cultural differences exist between themselves and their audience. This preliminary report of an on-going four-university study indicates that black male students enrolled in public-speaking classes at a predominantly white university report higher anxiety about public speaking than black females and white students.
The Pedagogical Challenge of Teaching Privilege, Loss, and Disadvantage in Classrooms of Invisible Social Identities

Often the ways in which we teach about privilege highlight the experiences of privileged groups in contrast to the experiences of students from less privileged social identity groups. This chapter explores pedagogical exercises that may help people see invisible privileges, but at the same time highlights the extent and acute feelings related to the disadvantaged position. This may present a particularly complex challenge when facing a classroom of individuals for whom a stigmatized identity may not be visible (e.g., sexual orientation, gender non-conforming). In this chapter, I will attempt to address the challenge of countering prevailing hegemonic worldviews in the classroom without simultaneously creating unproductive discomfort for sexual and gender minority students.
Introduction: Philosophical Space

In its simplest sense, space for the ancients, East or West, was where things happened, the uncontained container of events. For some Indian schools it was the non-human source of touch and position. For Hindu and Greek atomists alike, space was the emptiness which atoms required for their motion. Euclid held that it possessed three dimensions and that geometry was its science. One of the earliest definitions of matter was that it occupied space, and for the Eleatic philosopher, Zeno, spatial extension was the line between something and nothing. If something did not occupy space it was nothing. All of these ideas of place, position, sequence, dimension can also be applied as analogies to thinking as well, for any idea occupies a position in a train or sequence of ideas, has origins and ends. Understanding what a word means is to locate it in the thought contexts which it symbolizes. The analogies that can be made between our thinking of space and the space of our thinking provide the basis for what I am calling philosophical space and is the beginning of this guide …
Disulfide cross-linking influences symbiotic activities of nodule peptide NCR247

Abstract Interactions of rhizobia with legumes establish the chronic intracellular infection that underlies symbiosis. Within nodules of inverted repeat-lacking clade (IRLC) legumes, rhizobia differentiate into nitrogen-fixing bacteroids. This terminal differentiation is driven by host nodule-specific cysteine-rich (NCR) peptides that orchestrate the adaptation of free-living bacteria into intracellular residents. Medicago truncatula encodes a family of >700 NCR peptides that have conserved cysteine motifs. NCR247 is a cationic peptide with four cysteines that can form two intramolecular disulfide bonds in the oxidized forms. This peptide affects Sinorhizobium meliloti transcription, translation, and cell division at low concentrations and is antimicrobial at higher concentrations. By preparing the three possible disulfide–cross-linked NCR247 regioisomers, the reduced peptide, and a variant lacking cysteines, we performed a systematic study of the effects of intramolecular disulfide cross-linking and cysteines on the activities of an NCR peptide. The relative activities of the five NCR247 variants differed strikingly among the various bioassays, suggesting that the NCR peptide-based language used by plants to control the development of their bacterial partners during symbiosis is even greater than previously recognized. These patterns indicate that certain NCR bioactivities require cysteines whereas others do not. The results also suggest that NCR247 may exert some of its effects within the cell envelope whereas other activities occur in the cytoplasm. BacA, a membrane protein that is critical for symbiosis, provides protection against all bactericidal forms of NCR247. Oxidative folding protects NCR247 from degradation by the symbiotically relevant metalloprotease HrrP (host range restriction peptidase), suggesting that disulfide bond formation may additionally stabilize NCR peptides during symbiosis.
The Ridge and Di-hadron Correlations from the BES at RHIC

Abstract Di-hadron correlations are a key observable in heavy-ion collisions, and play a critical role in establishing the equation of state for hot and dense nuclear matter. In this analysis, the first set of results of 2D di-hadron correlations (Δϕ, Δη) for Au+Au collisions with center-of-mass energies s N N = 7.7 , 11.5 , 14.5 , 19.6 , 27 , and 39 GeV from the STAR experiment is presented. Anisotropy coefficients of second and third orders ( ν 2 , 3 { 2 } ) from long range rapidity correlations of di-hadrons are obtained, and when scaled by multiplicity, ν 3 2 shows a non-monotonic behavior as a function of energy.
Mediating Women: Evelyn Sharp and the Modern Media Fictions of Suffrage

Among the many influences that suffragist authors drew from their New Woman precursors was an understanding of the central role of print media, particularly periodical culture, in constructing images and ideologies of the modern woman. Just as the New Woman was constructed from ‘foolscap and ink’ within the periodical press, so was the suffragette imaged and imagined within the vibrant periodical culture of the early twentieth century. My focus will be on the media fictions of Evelyn Sharp (1869–1955), a figure who bridges the periods considered by this collection on British women writers and whose long career as an activist, journalist, and fiction writer included contributing as a New Woman author to The Yellow Book, publishing a novel in John Lane’s famous Keynote series of New Woman fictions, and contributing, as a suffragette, short pieces to the paper of the Women’s Social and Political Union (WSPU), Votes for Women, a paper she eventually edited. The term ‘media fictions’ is meant to indicate not only fictions that appeared in the suffrage papers that circulated in England and elsewhere, but also fictions that were energized through representations of modern media forms and communication technologies. Sharp filled her short suffrage sketches of the Edwardian period with media. Depictions of suffrage papers, street selling, and representations of various modern technologies of communication, or vehicles of communication enhancement, organize the plots of a great number of her suffrage stories. Some of these objects are associated with the modern, such as the typewriter, and others are decidedly more retro, such as the ear-trumpet. Sharp’s media fictions meditate on the association of gender and media and explore the ways in which modern media forms make possible—often inexplicably or by accident—the feminist networks of the suffrage period. In the sense employed by Friedrich Kittler and others, the ‘network’ is explored in relation to its own generative force rather than the actions of individual human agents. Laurel Brake has demonstrated how important this approach can be for studies of the complex interconnections of presses, editors, book-sellers, and reviewers that compose the print cultural networks of modernity. In feminist print culture studies, where discussions of agency are central, the idea of the ‘network’ is often exploited for its metaphoric potential since it connects discussions of friendship communities with discussions of publishing, marketing, and distribution venues. It is this sense that will govern my approach and it is at this intersection of feminist community and the mobilization of media forms and communication technologies that Sharp invests her interest.
Meta‐Analysis of Counseling Outcomes for Youth With Conduct Disorders

Twenty-one clinical trials were synthesized using a random-effects model, which substantiated that counseling generally produces a medium effect in treating conduct disorder in youth at termination (d+ = 0.30 to 0.57; k = 28). However, the lasting effects at follow-up were unclear because few follow-up studies (k = 13) have been conducted (d+ = −0.53 to 0.58), and only 2 randomized controlled follow-up studies were located. No effects of moderating variables were evident. Implications for counseling practice and outcome research are addressed.
Influence of guideline-concordant adjuvant therapy on all-cause and disease-specific survival among breast cancer patients in rural Georgia.

1130 Background: This study examines whether receipt of chemo-, radiation, and hormonal therapy regimens that are jointly guideline concordant improve survival outcomes among women diagnosed with b...
Zooplankton swarms: characteristics, proximal cues and proposed advantages

This review focuses on monospecific swarms of four taxonomic groups of small crustaceans: three groups are marine copepods: oithonids (Oithona and Dioithona), Acartia species and Calanus species; and the fourth group includes freshwater cladoceran species in the Order Anomopoda. For each of these groups there is a substantial literature on swarming behavior from field studies and laboratory experiments. Swarming characteristics of each taxonomic group are reviewed, proximal cues for swarming are described, comparisons are made for proposed advantages of swarming, and future research directions are suggested. Swarming characteristics of Calanus spp. are distinctly different from those of the smaller crustaceans: the oithonids, acartiids and cladocerans. In a conceptual model proposed for the smaller crustaceans, swarming behavior is affected by their interactions with light cues, water currents and turbulence, behavior of their predators and prey, and abundance of other trophic levels.
Ab initio study of mode-resolved phonon transmission at Si/Ge interfaces using atomistic Green's functions

Solid interfaces with exceptionally low or high thermal conductance are of intense scientific and practical interest. However, realizing such interfaces is challenging due to a lack of knowledge of the phonon transmission coefficients between specific modes on each side of the interface and how the coefficients are affected by atomic scale structure. Here, we report an ab initio based study of phonon transmission at Si/Ge interfaces using a recent extension of the atomistic Green's function method that resolves transmission coefficients by mode. These results provide a detailed framework to investigate the precise transmission and reflection processes that lead to thermal resistance and how they depend on phonon frequency as well as incident angle. We find that the transmission and reflection processes can be partly explained with familiar concepts such as conservation of transverse momentum, but we also find that numerous phonons have zero transmission coefficient despite the existence of modes that satisfy transverse momentum conservation. This work provides detailed insights into precisely which phonons transmit or reflect at interfaces, knowledge necessary to design solid interfaces with extreme values of thermal conductance for thermoelectricity and heat management applications.
Game-Changers: A Prolegomenon to a Theory of Modern Chinese Poetry

In this bold new essay, Michelle Yeh, Professor of Chinese Literature at the University of California, Davis, appropriates the notion of “game-changers” from American popular culture and politics to complicate literary theory's general dismissal of authorial agency by asserting that literary history is not directed but rather redirected by those authors whose work not only embraces the implicit literary rules of their time but transcends these rules, thereby changing the literary criteria and the cultural spaces that authors inhabit.
An integrated microstructural-nanomechanical-chemical approach to examine material-specific characteristics of cementitious interphase regions

Abstract Effective properties and structural performance of cementitious mixtures are substantially governed by the quality of the interphase region because it acts as a bridge transferring forces between aggregates and a binding matrix and is generally susceptible to damage. As alternative binding agents like alkali-activated precursors have obtained substantial attention in recent years, there is a growing need for fundamental knowledge to uncover interphase formation mechanisms. In this paper, two different types of binding materials, i.e., fly ash-based geopolymer and ordinary portland cement, were mixed with limestone aggregate to examine and compare the microstructures and nanomechanical properties of interphase region. To this end, microstructural characteristics using scanning microscopies, nanomechanical properties by nanoindentation tests, and spatial mapping of chemical contents based on the energy dispersive spectroscopy were integrated to identify and investigate the interphase region formed by the case-specific interactions between the matrix materials and limestone. The integrated microstructural-nanomechanical-chemical approach was effective to better understand links between material-specific properties of cementing phases. More specifically, the fly ash-based geopolymer paste was usually well bonded to the aggregate surface with a rich formation of N-A-S-H gel, while interfacial debonding was often observed between aggregate surface and paste in ordinary portland cement concrete. However, when a good bonding between aggregate and paste is formed, interphase region in PCC did not show any considerable difference in nanomechanical properties compared to the bulk paste.
Privacy at the Margins| Not the Normal Trans Story: Negotiating Trans Narratives While Crowdfunding at the Margins

This study reports findings from in-depth semistructured interviews with 20 transgender-identifying individuals to understand how they negotiate privacy while crowdfunding to finance top surgery. Participants expressed privacy concerns about the body becoming public and fears of being criticized or attacked. Crowdfunding also necessitated a discussion of the fact that participants had breasts, which was distressing to some. Despite all of this, most participants embraced the crowdfunding experience as an opportunity to share their stories and to reject what they viewed as the normal trans narrative as too narrow. Findings suggest an intensification of privacy calculus theory as it applies to individuals from marginalized communities: Perceived costs and benefits of online disclosure may be greater when publicizing an identity that is often subject to attack. In addition to privacy calculus theory, we use the identity shift framework and taxonomies of privacy to explore tensions between publicness, privacy, self-expression, and support.
Abstract P1-07-31: Integrated transcriptomics analyses identify novel three microRNAs signature to predict poor prognosis and metastasis in breast cancer

Backgrounds : MicroRNA (miRNA) play a crucial role in cancer progression, and altered miRNA expression has been demonstrated to be associated with breast cancer. MiRNA is also known to be stably detectable not only in tissue but peripheral circulation; therefore it could be a feasible and potential biomarker of breast cancer in clinical settings. However, few studies have been reported to identify promising miRNA profiles as predictive biomarker using statistically satisfied large cohorts of breast cancer patients. The aim of this study is to identify miRNA signature that can predict patient survival utilizing integrated and unbiased transcriptomics analyses. Methods : Integrated and unbiased transcriptomics approach was conducted on genomic and clinicopathological information of 2580 breast cancer patients. We utilized The cancer Genome Atlas (TCGA) to identify miRNA signature that could significantly associated with clinical relevance including prognosis and metastatic information, followed by validation analyses with the Molecular Taxonomy of Breast Cancer International Consortium (METABRIC) and Gene Expression Omnibus (GEO) Results : A novel risk scoring model including three miRNAs signature (miR-19a, miR-93, and miR-106a) was identified using Cox model. This miRNA score was able to extract the patient population with extremely poor prognosis in TCGA (5-yr overall survival rate, 49.2 %, p=0.0005). This result was validated with another three completely independent cohorts with microarray dataset accompanied with sufficient clinical information and miRNA expression (GSE19536, n=96, p=0.0009; GSE22220, n=210, p=0.0003; METABRIC, n=1223, p=0,0023). Interestingly, the subtype stratification with PAM-50 classification using bioinformatics pipeline demonstrated that this miRNA score could predict poor overall or disease-free survival especially in the population with luminal A, B or normal like subtype (p=0.0300 and p=0.0001, respectively). In addition, competing risk analysis for tumor recurrences demonstrated that the risk scoring using three miRNAs signature could be significantly associated with bone metastasis (p=0.0052). Finally, Gene Set Enrichment Analysis (GSEA) identified that high risk score using three miRNAs associated significantly with several critical gene sets related to metastatic formation such as angiogenesis (p Conclusions : We demonstrated a promising miRNAs signature score system for predicting extremely poor prognosis and metastatic potentiality in breast cancer using novel integrated transcriptomics concept. Citation Format: Takabe K, Kawaguchi T, Yan L, Qi Q, Peng X, Young J, Liu S. Integrated transcriptomics analyses identify novel three microRNAs signature to predict poor prognosis and metastasis in breast cancer [abstract]. In: Proceedings of the 2017 San Antonio Breast Cancer Symposium; 2017 Dec 5-9; San Antonio, TX. Philadelphia (PA): AACR; Cancer Res 2018;78(4 Suppl):Abstract nr P1-07-31.
Teaching basic game programming using JavaScript

JavaScript is a sophisticated modern object-based scripting language. Although it has technical restrictions, it has sufficient features to create Web games, or games people play through the Web. Using JavaScript students can learn the concepts and immediately present their web games to the Web. This paper reports how the author successfully uses JavaScript to teach basic key concepts in a college-level introductory course of game programming.
Achromycin®-V (Lederle)

Tetracyclines are mainly bacteriostatic and are thought to exert their antimicrobial effect by the inhibition of protein synthesis in a wide range of gram-negative and gram-positive organisms. Tetracyclines are readily absorbed and bind to plasma proteins.
A user's guide to a short course on professional ethics and the work of a national statistical office

1. Background There is growing recognition of the important role that ethics can play in many aspects of the work of a National Statistical Office (NSO). This implies that the leadership and staff of NSOs should be aware of the common ethical concerns that arise in the course of their work and the ethical guidance provided by applicable national, regional, and international norms. (Although the term NSO is used here, in countries where the national statistical system is less centralized, the term “statistical agency” can be substituted without altering the meaning of what is being said.) In response to this interest the International Statistical Institute (ISI) organized a short course on Professional Ethics at the 57th session of the International Statistical Institute, held in Durban, South Africa, 16-22 August 2009. The course was divided into three sections: Part I of the course dealt with general issues, part II with professional ethics and the work of a national statistical office, and part III with research ethics in biomedical applications, presented by Ron Wasserstein, William Seltzer, and Norbert Victor, respectively. Subsequently, the author revised and expanded part II of the course to be a stand-alone course. The revised course, “Professional Ethics and the Work of a National Statistical Office,” is available as a 70-slide PowerPoint presentation at https://pantherfile.uwm.edu/margo/www/govstat/integrity.htm. It may be copied and used for any non-commercial purpose. The primary purpose of this user’s guide is to serve as an aid for those thinking about presenting the course to a group of participants. With this in mind, the guide describes the course and offers some suggestions on its presentation, with a view to encouraging relevant training in ethics for persons involved in the work of national statistical offices (NSOs). Alternatively, the PowerPoint presentation can be used as the basis of a self-study course and this guide will then serve as a student’s guide. However, there are distinct advantages in taking part in this course as part of a group exercise. The group discussion of the issues raised, whether on ethical priorities and trade-offs or on the sometimes
Forest iteration method for stochastic transportation problem

The transportation problem with stochastic demands is a special version of the stochastic linear programming problem with simple recourse. It has many economic applications. In this paper we present a new algorithm to solve this problem. Instead of discretizing the distribution functions of the stochastic demands, we explore the problem’s network aspects and propose a forest iteration method to solve it. This method iterates from one base forest triple to another base forest triple with strictly decreasing objective values. Therefore, it converges in finitely many steps. The nonlinear work in each step consists of solving a small number of one-dimensional monotone equations.
Demonstration: API Federation in the BigDAWG Polystore

The BigDAWG polystore has been a successful demonstration of the principle that “one size does not fit all” in the world of database management. BigDAWG binds together multiple diverse sets of datastores to form a cohesive unit that allows users to focus their data analysis using the most appropriate store for data and the result set without the time consuming and cumbersome Extract-Transform-Load (ETL) pipelines and their associated setup processes. In this article, we introduce a new BigDAWG Island that can be used to pull data from API-based data sources to enrich the access to remote data and enhance BigDAWG’s capabilities.
Women’s triple-negative, first-line treatment: Improving outcomes in triple-negative breast cancer (TNBC) using molecular triaging and diagnostic imaging to guide neoadjuvant therapy (NACT).

TPS1113 Background: In TNBC, pathologic compete response (pCR/RCB-0) or minimal residual disease (RCB-I) to NACT is associated with a good prognosis while extensive residual disease (RCB-II-III) ha...
Evaluating Continental Shelf Seabed-Elevation Changes from Archived Sediment-Core Records: Issues with Vertical Positioning and Implications for Integration with Subsurface Geophysics

ABSTRACT Mattheus, C.R.; Ramsey, K.W., and Santoro, J.A., 2020. Evaluating continental shelf seabed-elevation changes from archived sediment-core records: Issues with vertical positioning and impli...
Cerebral Small Vessel Disease among US minority Survivors of Intracerebral Hemorrhage

Background Black and Hispanic survivors of Intracerebral Hemorrhage (ICH) are at higher risk of recurrent intracranial bleeding when compared to their white counterparts. While established differences in hypertension severity after ICH play a role, they do not fully account for this health disparity. MRI-based markers of chronic Cerebral Small Vessel Disease (CSVD) are consistently associated with increased risk of recurrent ICH. We therefore sought to investigate whether differences in CSVD subtype and/or severity exist among self-reported race/ethnicity groups. Methods We utilized data from the MGH-ICH study and the ERICH-L study. We collected baseline patient information and MRI-based CSVD markers, in the form of cerebral microbleeds (CMBs). We conducted univariable and multivariable analyses for presence and burden of CMBs, differentiating on the basis of two primary CSVD subtypes: Cerebral Amyloid Angiopathy (CAA) and Arteriolo-Sclerosis (AS). Results We analyzed data for a total of 2192 ICH survivors (MGH-ICH study: 991 and ERICH-L: 1201). Of these, 1245 self-identified as white, 460 as black, 392 as Hispanic, and 67 as other race/ethnicity. We found that minority ICH survivors were more likely to have CMBs on MRI scan at time of ICH compared to white participants (54% vs. 41%, p Conclusion Minority ICH survivors presented with greater CSVD burden on MRI scan at time of stroke, especially as it pertains to the AS-subtype. Given the known association between AS and hypertension, our findings may reflect disparities in primary stroke prevention long pre-dating ICH. Future studies will be required to clarify the impact of our findings on ICH recurrence risk.
Complexity of Aortic Arch Anatomy Affects the Outcomes of Transcarotid Artery Revascularization Versus Transfemoral Carotid Artery Stenting.

Background Transcarotid artery revascularization (TCAR) has been shown to have half the rates of transient ischemic attack (TIA), stroke, and death compared with transfemoral carotid artery stenting (TFCAS). Successful outcomes of TFCAS require careful patient selection. The aim of this study was to determine the outcomes of TFCAS versus TCAR in both simple (type I) and complex (type II and III) aortic arches. Methods A retrospective cohort study was performed comparing the outcomes of patients undergoing TFCAS versus TCAR with simple and complex aortic arches using the Vascular Quality Initiative registry from August 2011 to May 2019. The primary outcome was a composite of in-hospital TIA/stroke/death. Results About 6,108 carotid artery interventions were analyzed, including 3,536 (57.9%) patients with type I, 2,013 (33.0%) with type II, and 559 (9.2%) with type III aortic arch. In 3,535 patients with a simple arch, 1,917 underwent TFCAS and 1,619 had TCAR. Mean age was 70.6 (±9.5) years, and 2,382 (67.4%) patients were males. The primary outcome of postoperative TIA/stroke/death was seen significantly less frequently in those undergoing TCAR compared with TFCAS in simple arches (odds ratio [OR], 0.63; 95% confidence interval [95% CI], 0.43–0.94; P = 0.0236). Although the individual outcome of death occurred less often in TCAR (P = 0.0025), there was no difference in the occurrence of in-hospital stroke (P = 0.8836) or TIA (P = 0.4608). On multivariable analysis, TCAR was associated with improved outcomes (P = 0.0062). A worse outcome was associated with increasing age (P Conclusions TCAR has improved outcomes of TIA/stroke/death compared with TFCAS in both simple and complex aortic arch anatomy. In simple aortic arches, there is no difference in neurologic outcomes between both approaches. In complex arch anatomy, TCAR has fewer strokes.
APPLICATIONS OF ULTRASONIC SOUND BEAMS IN PERFORMANCE AND SOUND ART

Ultrasound technology has been used in many fields for measurement, imaging, and even therapeutic goals. Recently ultrasound has become available as a medium to create hyper-directional sound beams, enabling the ability to manipulate sound projection in a way analogous to light. This paper presents a brief overview of ultrasound audio technology, and introduces several lines of investigation related to applications of sound beams in performance and sound art currently under development at our center.
Chapter 5 – Incident Response: Live Forensics and Investigations

Publisher Summary This chapter discusses the need to move away from traditional methods of computer forensics and toward a live forensics model. The chapter concludes that computer forensics will change dramatically. The release of Microsoft's Vista will enable users to fully encrypt their hard drives. It is surmised in the chapter that traditional forensics will become more impractical, and live investigations will become a necessity rather than a luxury. Traditional methodologies are becoming somewhat obsolete. The chapter also concludes that the need to adopt a new way of conducting these types of investigations is essential. The chapter attempts to make the reader able to provide a reasonable explanation to any judge or jury as to why live forensics was used in place of traditional methods. However, should none of these circumstances exist, it may be best just to pull the plug.
Changes in Clinical Presentation and Treatment Over Time in Patients with Unruptured Intracranial Arteriovenous Malformations

Objective Treatment of unruptured intracranial arteriovenous malformations (AVMs) has become controversial since the ARUBA (A Randomized Trial of Unruptured Brain Arteriovenous Malformations) study was published in 2014. We sought to analyze changes in the demographics, clinical presentation, and treatment strategies in 2 patient cohorts from the same institution separated by 40 years. Methods We retrospectively reviewed the electronic medical records for a consecutive series of patients with unruptured intracranial AVMs seen at the Mayo Clinic between 2003 and 2017 and compared them with a previously published historical cohort from the same institution seen between 1974 and 1985. Results There were 273 patients in the contemporary cohort, of which discovery of the AVM was incidental in 123 (45.1%), a 3.5-fold increase compared with the 13.1% out of 168 patients in the historical cohort (P Conclusions Compared to 40 years ago, more patients are presenting with incidentally discovered intracranial AVMs and are undergoing interventional treatment. Better understanding of the natural history, developments in endovascular therapy, and stereotactic radiosurgery, as well as improvements in microsurgical techniques have led to a substantial increase in patients undergoing invasive treatment.
Ensemble Learning for Detecting Fake Reviews

Customers represent their satisfactions of consuming products by sharing their experiences through the utilization of online reviews. Several machine learning-based approaches can automatically detect deceptive and fake reviews. Recently, there have been studies reporting the performance of ensemble learning-based approaches in comparison to conventional machine learning techniques. Motivated by the recent trends in ensemble learning, this paper evaluates the performance of ensemble learning-based approaches to identify bogus online information. The application of a number of ensemble learning-based approaches to a collection of fake restaurant reviews that we developed show that these ensemble learning-based approaches detect deceptive information better than conventional machine learning algorithms.
Asymmetric synthesis with ynamides: unique reaction control, chemical diversity and applications.

Ynamides are among the most powerful building blocks in organic synthesis and have become invaluable starting materials for the construction of multifunctional compounds and challenging architectures that would be difficult to prepare otherwise. The rapidly growing popularity originates from the unique reactivity and ease of manipulation of the polarized ynamide triple bond, the advance of practical methods for making them, and the simplicity of storage and handling. These attractive features and the demonstration of numerous synthetic applications have spurred the development of intriguing asymmetric reaction strategies during the last decade. An impressive variety of chemo-, regio- and stereoselective carbon–carbon and carbon–heteroatom bond forming reactions with ynamides have been developed and now significantly enrich the toolbox of synthetic chemists. This review provides a comprehensive overview of asymmetric ynamide chemistry since 2010 with a focus on the general scope, current limitations, stereochemical reaction control and mechanistic aspects.