cssi/SciSciGPT-SciSciNet huggingface dataset:
Faculty assessment of scholarship of teaching and learning among United States pharmacy programs.

Abstract Introduction Pharmacy faculty understanding of the scholarship of teaching and learning (SoTL) and its recognition remain unclear. This study aimed to determine faculty SoTL perceptions and whether it should be recognized in promotion and tenure decisions. Methods A survey instrument was developed and distributed to 6454 faculty in 139 United States pharmacy programs. The survey provided a list of scholarly activities and respondents were asked to select activities they perceived as SoTL and solicited faculty attitudes toward SoTL, its recognition and value in promotion and tenure, and SoTL engagement. Results were stratified based on SoTL participation, disciplines, and years of experience. Results Six hundred forty-three pharmacy faculty responded to the survey. Diverse scholarly works from teaching and learning practices to curriculum development, which lead to peer-reviewed public dissemination, were perceived as SoTL by most (78–98%) of the respondents. Participation in SoTL was reported by 74%. Pharmaceutical/biomedical science faculty were significantly less likely to accept the SoTL definition than pharmacy practice or social and administrative sciences faculty. Over 90% of participants indicated that college/school and departmental policies should encourage participation in SoTL activities. More than 70% of respondents strongly agreed that SoTL should be incorporated into criteria for promotion and tenure. Competing time commitments, lack of funding, interest, and institutional SoTL recognition were identified as challenges. Conclusion Findings demonstrate that pharmacy faculty perceive SoTL as a broad spectrum of scholarly activities, including classroom practices and beyond, that culminate into peer-reviewed public dissemination. Pharmacy faculty support the incorporation of SoTL into promotion and tenure criteria.
Giant Cell Carcinosarcoma of the Parotid Gland With a PLAG 1 Translocation in Association With a Pleomorphic Adenoma With HMGA2 Translocation.

Objectives Carcinosarcomas of the salivary gland are rare neoplasms and have been described arising de novo or in association with pleomorphic adenoma (PA). PLAG1 and HMGA2 translocations are known to occur in PAs and carcinomas ex PA but are mutually exclusive. Methods We report a case of a carcinosarcoma in the parotid gland of a 77-year-old man with unusual anaplastic sarcomatoid giant cell morphology. Results Microscopically, a small separate PA was found adjacent to the carcinosarcoma. By conventional notion, the PA and carcinosarcoma would be considered related, as carcinosarcomas are well known to arise from PAs (carcinosarcoma ex PA). However, fluorescence in situ hybridization (FISH) assay demonstrated PLAG1 translocation in the carcinosarcoma and HMGA2 translocation in the separate PA. Conclusions These findings support that the carcinosarcoma likely originated from another PA with a PLAG1 translocation or de novo but not from the coexisting PA harboring a different translocation. To our knowledge, the case is the first to demonstrate PLAG1 translocation by FISH in a sarcomatous component of any parotid gland tumor, which may help better classify these tumors. In addition, multiple PAs are commonly found in the salivary gland, and to our knowledge, our case is the first to demonstrate that the same parotid gland can host PAs and PA-related tumors with different translocations.
From the Life to the Mind of the Writer in the Literary Biopic: Andrucha Waddington’s Lope and Ray Loriga’s Teresa

Lope (Andrucha Waddington 2010) and Teresa (Ray Loriga 2007) have much in common. Both biopics center on a revered literary figure of the Spanish Golden Age. However, in spite of their many commonalities, these films embody two distinct tendencies in the contemporary literary biopic genre: one more “typical,” represented by Lope, that focuses heavily on plot development and another, represented by Teresa, that aspires to visually transpose to the screen aspects that relate to the main character’s interiority. Although Teresa has features of the “typical” contemporary literary biopic, it innovates the genre significantly by moving its focus from the life to the mind of the writer. Loriga uses the language of cinematography to depict the imagery and affective qualities of the mysticism of Teresa de Avila—the force behind her writings—, creating a film that emphasizes image and emotions over plot. Teresa thus brings a different sensitivity to the literary biopic, which deviates from more formulaic films. Centering on the author’s mind can indeed be a new path for filmmakers to innovate the biopic genre, particularly in its literary strand. Finally, these two biopics illustrate the need to expand the scholarly conversation about the contemporary literary biopic genre, as they both engage with and deviate from the formula established by Anglo-Saxon biopics.
Recent progress of probing correlated electron states by point contact spectroscopy

We review recent progress in point contact spectroscopy (PCS) to extract spectroscopic information out of correlated electron materials, with the emphasis on non-superconducting states. PCS has been used to detect bosonic excitations in normal metals, where signatures (e.g. phonons) are usually less than 1% of the measured conductance. In the superconducting state, point contact Andreev reflection (PCAR) has been widely used to study properties of the superconducting gap in various superconductors. It has been well-recognized that the corresponding conductance can be accurately fitted by the Blonder-Tinkham-Klapwijk (BTK) theory in which the AR occurring near the point contact junction is modeled by three parameters; the superconducting gap, the quasiparticle scattering rate, and a dimensionless parameter, Z, describing the strength of the potential barrier at the junction. AR can be as large as 100% of the background conductance, and only arises in the case of superconductors. In the last decade, there have been more and more experimental results suggesting that the point contact conductance could reveal new features associated with the unusual single electron dynamics in non-superconducting states, shedding a new light on exploring the nature of the competing phases in correlated materials. To correctly interpret these new features, it is crucial to re-examine the modeling of the point contact junctions, the formalism used to describe the single electron dynamics particularly in point contact spectroscopy, and the physical quantity that should be computed to understand the conductance. We will summarize the theories for point contact spectroscopy developed from different approaches and highlight these conceptual differences distinguishing point contact spectroscopy from tunneling-based probes. Moreover, we will show how the Schwinger-Kadanoff-Baym-Keldysh (SKBK) formalism together with the appropriate modeling of the nano-scale point contacts randomly distributed across the junction leads to the conclusion that the point contact conductance is proportional to the effective density of states, a physical quantity that can be computed if the electron self energy is known. The experimental data on iron based superconductors and heavy fermion compounds will be analyzed in this framework. These recent developments have extended the applicability of point contact spectroscopy to correlated materials, which will help us achieve a deeper understanding of the single electron dynamics in strongly correlated systems.
Genome-wide analysis of focal DNA hypermethylation in IDH-mutant AML samples

Altered DNA methylation is a common feature of acute myeloid leukemia (AML) and is thought to play a significant role in disease pathogenesis. Gain of function mutations in IDH1 or IDH2 result in widespread but highly focal regions of hypermethylation across the genome that occurs due to the production of 2-hydroxyglutarate that inhibits TET-mediated demethylation. We used whole-genome bisulfite sequencing to identify canonical regions of DNA hypermethylation that are associated specifically with IDH1 and IDH2 mutations in primary AML samples. Consistent with previous reports, IDH mutant (IDHmut) AMLs were the most hypermethylated among all mutationally-defined AML categories analyzed. We observed notable differences in the degree of hypermethylation associated with IDH mutation type, with IDH1mut AMLs having more profound hypermethylation at specific regions than IDH2mut samples. AMLs with biallelic inactivating mutations in TET2 displayed more modest DNA methylation changes compared to normal hematopoietic stem/progenitor cells, but methylation in these samples was increased in the IDHmut-specific regions, providing further support that these mutations act on the same TET-mediated demethylation pathway. Focal hypermethylated regions in IDHmut AML samples tended to occur in regions with low steady state methylation levels in normal stem/progenitor cells, which implies that both DNA methylation and demethylation pathways are active at these loci. Indeed, analysis of AML samples containing mutations in both IDH1 or IDH2 and DNMT3AR882 were less hypermethylated, providing evidence that focal IDHmut-associated hypermethylation is mediated by DNMT3A. IDHmut-specific regions of hypermethylation were largely distinct from CpG island hypermethylation, and showed a significant enrichment for putative enhancers. Analysis of three-dimensional genome interactions from primary hematopoietic cells showed that differentially methylated enhancers formed direct interactions with highly expressed genes, including MYC and ETV6. Taken together, these results suggest that focal hypermethylation in IDH-mutant AML cells occurs by disrupting the balance of DNA methylation and demethylation, which is highly active in genomic regions involved in gene regulation.
iPSC-derived pancreatic progenitors are an optimal model system to study T2D regulatory variants active during fetal development of the pancreas

Pancreatic progenitor cells (PPCs), which are multipotent cells that have the potential to give rise to endocrine, exocrine and epithelial cells, provide a powerful model system to examine the molecular characteristics of differentiating, fetal-like pancreas cells and to study the genetics of pancreatic disease. We differentiated ten induced pluripotent stem cell-derived pancreatic progenitor cell (iPSC-PPC) lines and, using single cell RNA-seq and single nuclear ATAC-seq, we found that they show varying levels of cellular maturity, including the presence of early PPC, endocrine and exocrine cells. We evaluated iPSC-PPC as a model system to study type 2 diabetes (T2D) and found that, of 380 T2D risk loci, 208 overlapped regulatory elements active in iPSC-PPC, including 55 fetal-specific. These loci are associated with transcription factor binding site alterations and allele-specific expression, suggesting that iPSC-PPC are an optimal model system to annotate GWAS variants that are not functional in the adult pancreas.
Generator Parameter Identification Using Time Series Model and PMU Measurements

Dynamic simulation is one of the most important tools for the operation and planning of electric power systems. Accuracy of the dynamic simulation results are directly determined by the accuracy of the equipment model, especially the models of synchronous generators. This paper proposes a time-series-based synchronous generator parameter estimation technique using phasor measurement unit (PMU) data. The generator electromechanical dynamics related parameters are estimated which include generator inertia constant, speed regulation constant, and time constant of the turbine-governor, etc. The classical generator model and swing equation are transformed into a time series model whose parameters can be estimated in an indirect way using linear system parameter identification technology. Once the parameters for the time series model are calculated, the generator parameters can be recovered from the time series model. Simulation results demonstrate the effectiveness of the proposed methodology.
Collaborative Augmented Reality for Better Standards

Concurrent engineering depends on clear communication between all members of the development process. As that communication becomes more and more complex, the quality of the standards used to move and understand that information likewise becomes more and more important. If the standard is incomplete, redundant, or ambiguous, most of the expected benefits are lost. In order to improve data exchange standards, explicit data models are required. However, creating those data models is a process that requires collaboration between domain experts. What is needed is a solution that encourages interaction without requiring a high level of data modeling expertise. Focus is a software tool designed to provide such an environment. It is a distributed design and conferencing application which uses augmented reality to allow domain experts to come together in real time for data modeling. By developing Focus, we hope to allow domain experts to create data models without first having to learn complex UML modeling programs. Because of the networked nature of Focus, it is easier to ensure the participation of the best domain experts regardless of location. This paper details the development, features, and expected benefits of Focus in a collaborative engineering environment.
Feminist Perspectives in African Fiction: Bessie Head and Buchi Emecheta

(1986). Feminist Perspectives in African Fiction: Bessie Head and Buchi Emecheta. The Black Scholar: Vol. 17, The Black Woman Writer and the Diaspora, pp. 34-40.
Dielectric strength of crosslinked polyethylene: the effects of the volatile products of the crosslinking reaction

The breakdown field strength of recessed samples of XLPE (cross-linked polyethylene) containing varying amounts of acetophenone and cumene is shown to decrease with increasing sample thickness. This thickness dependence is more complicated than previously observed. The addition of small amounts of acetophenone to XLPE produces a small increase in the dielectric strength. Small concentrations of cumene have no effect. Results from both AC ramp to failure and impulse breakdown can be fit to Weibull distributions. The characteristic values obtained from ramp to failure measurements depend on the ramp rate as suggested by theory. >
The Effects of Cocaine and Amphetamine Use During Pregnancy on the Newborn: Myth versus Reality

The fact that some women use and abuse substances during pregnancy is a source of great consternation and concern in science and in society. The knowledge of the harm associated with drug consumpti...
Immigration Reform and the Potential for Psychosocial Trauma: The Missing Link of Lived Human Experience

Immigration reform has come to the forefront of the political arena again, most recently sparked by the controversy surrounding Arizona Senate Bill (ASB) 1070. Mostly missing from these discussions is a focus on the impact upon lived human conditions that may result from such legislative reform. This article examines the literature regarding the stress and potential psychosocial trauma that may be associated with immigration and the acculturation process, with an emphasis on the effects of the ASB 1070. The article concludes by identifying relevant implications for research.
White Dwarf Mass Loss, Rotation, Individual Masses and the Identification of the White Dwarf Remnants of Upper Main Sequence Stars

This review focuses upon current observational evidence of white dwarf mass loss, rotation rates and the identification of evolutionary (progenitor) links between white dwarfs and upper main sequence stars. The latter objective rests upon the determination of white dwarf masses through a number of methods, which are discussed. The conclusions are as follows: (1) There is some evidence in the far ultraviolet to suggest that hot DA white dwarfs lose mass via a weak wind. This mass outflow is manifested by the presence of sharp, shortward-shifted absorption lines in the IUE high resolution spectra of a number of hot DA white dwarfs (Bruhweiler and Kondo 1983). There is at present very weak direct evidence of actual mass loss by hot non-DA white dwarfs, except for strong wind outflow from the lower gravity pulsating central star of K1–16. The DO stars, KPD 0005+5106 and PG 1034+001, may be important exceptions; (2) The general conclusion at present concerning white dwarf rotation rates is that they are slow rotators with established upper limit υ sin i 0.6 M⊙) and therefore no link is indicated between these objects and upper main sequence progenitors; (4) At the present time it is not clear whether massive white dwarf progenitors would be expected to leave DA or non-DA remnants. Here, theory and observation provide conflicting indications; (5) The magnetic degenerates tend to have higher than average white dwarf mass and the majority are therefore expected to be the progeny of young, peculiar A and B stars on the upper main sequence. This conclusion is supported by a number of independent lines of evidence; (6) Higher-than-average mass white dwarfs (and therefore the remnants of progenitors more massive and younger than the typical and most populous old disk stars in the solar neighborhood), have been identified through kinematical properties, through gravitational redshift determinations in wide and common proper motion binaries, through kinematical membership in young moving groups, through the gravitational redshifts of the white dwarf members of the Hyades cluster, and through the spectroscopic identification and analysis of white dwarf members of very young open clusters whose turnoff masses to the red giant branch exceed 5 M⊙; A number of evolutionary implications and future prospects are discussed.
Metro area transparent WDM optical networks

The performance of transparent metropolitan area networks utilizing cost-effective, application-optimized, optical layer components and fiber is discussed. Results for 2.5 Gb/s and 10 Gb/s per channel bit-rates are presented.
Science as a Second Language

for DBER Group Discussion on 2014‐02‐13 Presenter(s), Department(s): Dr. Stephanie Wessels Assistant Professor Teaching, Learning and Teacher Education University of Nebraska‐Lincoln Title: Science as a Second Language Abstract: Science classes for English Language Learning (ELL) students can be challenging because they are faced with learning both science content and the English language at the same time. ELL students are less likely to have the vocabulary needed to comprehend informational text, and so instruction that helps build both general academic and content‐specific vocabulary knowledge is particularly critical. In this presentation, I will present an overview of research‐based teaching strategies that are appropriate for science will be described and their theoretical underpinnings will be discussed. Attachments after PowerPoint slides: (1) blank Dots Evaluation template (2) blank Uncover‐Connection‐Me Evaluation template Science as a Second Language Dr. Stephanie Wessels Content Area Reading • As U.S. schools focus on teaching grade-level content to English language learning students (ELLs), ELLs’ reading skills in the content areas is critical, both for successful learning while in ESL, and for a smooth transition to mainstream classrooms. – However, ELLs still struggle when reading in the content areas especially science. • As a content area, science is unforgiving in terms of the constant need to build knowledge and the technical terminology needed to express that knowledge (Bravo, Hiebert, & Pearson, 2007).
Stock removal rate and workpiece strength in multi-pass grinding of ceramics

Abstract Stock removal rate and workpiece strength are evaluated in terms of machine stiffness and grinding wheel parameters in multi-pass grinding of silicon nitride ceramics. This paper presents theoretical analyses on normal grinding force, actual depth of cut (ADOC) of a grinding wheel, stock removal rate and residual strength of ground workpieces, as well as experimental results to verify the analyses. In the grinding experiments, silicon nitride workpieces are subjected to multi-pass grinding with four diamond wheels of three grit sizes and two bond types, as well as a precision grinder of adjustable stiffness. The electrolytic in-process dressing (ELID) technique is adopted to evaluate how wheel dressing can affect the workpiece strength and stock removal rate in multi-pass grinding. A discussion addresses the issues of strength gain and strength loss for ground workpieces and a recommendation is provided to obtain higher residual strength of ground workpiece.
Electron microscopy of amorphous GdCo alloy thin films

Transmissicn electron microscopy and electron diffraction were used to study the structural changes in amorphous GdCo films with temperature while Lorentz microscopy was employed to reveal the related magnetic changes. Amorphous GdCo films in the composition range of 75 to 85 at% Co precipitate small face centered cubic Co crystals in an amorphous matrix after heating at 400°C. As deposited these films were found to contain stripe as well as in-plane domain structures. Magnetic bubbles as small as 800 A could be generated in as deposited amorphous as well as partially crystallized films. In films with less than 79 at% Co the magnetic compensation point was demonstrated by a reversible reversal of domain contrast with temperature. Strukturelle Veranderungen dunner Schichten aus amorphem GdCo mit der Temperatur werden mit Hilfe von Elektronenmikroskopie und Elektronenbeugung untersucht. Damit verbundene Anderungen in den magnetischen Strukturen konnten durch Lorentzmikroskopie verfolgt werden. Wahrend des Temperns auf 400°C kristallisiert kubisch flachenzentriertes Co. Amorphe GdCo Schichten zeigten sowohl Streifendomanen (stripe domains) wie Magnetisierung in der Schichtebene. Zylinderdomanen mit 800 A Durchmesser konnten sowohl in aufgedampften wie auch in teilweise kristallisierten Schichten erzeugt werden. Der magnetische Kompensationspunkt konnte in GdCo Schichten mit < 79 At% Co durch reversible Umkehrung des magnetischen Domanenkontrastes mit der Temperatur demonstriert werden.
Application Of Iterated Function Systems And Skeletonization To Synthesis Of Fractal Images

ABSTRACT. In this paper we introduce some new techniques for modeling fractal images using concepts from the theory of iterated function systems and morphological skeletons. In the theory of iterated function systems, a fractal image can be modeled arbitrarily closely as the attractor of a finite set of affine maps. We use the morphological skeleton to provide us with sufficient information about the parameters of these affine maps. This technique has applications for fractal synthesis, computer graphics, and coding. Images that exhibit self-similarity, such as leaves, trees, mountains, and clouds, can be easily modeled using these techniques. Slight perturbations in the parameters of the model create variations in the image that can be used in animation. Finally, the small number of parameters in the model allows for very efficient image compression.
Nuclear test monitoring system detected meteor explosion over Russia

Sound waves from the Chelyabinsk meteor, which exploded over Russia on 15 February 2013, were detected by 20 infrasound stations that are part of the international monitoring system operated by the Comprehensive Nuclear-Test-Ban Treaty Organization (CTBTO). The fireball was the most energetic event observed since the 1908 Tunguska meteorite impact and is the most energetic event detected by the CTBTO network.
Aharonov-Bohm oscillations in a hydrogen atom in a radiation field through electron self-interference

We study the influence of a weak magnetic field on time evolution of a quantum state that is a coherent superposition of two counter-rotating Trojan wave packets in a linearly polarized electromagnetic field. We demonstrate that both the interference pattern of the electron probability density and differential cross section for half-cycle pulse ionization exhibit periodic modulation as a function of magnetic flux cutting the plane of packet motion. The shift is proportional to the magnetic flux in a way characteristic for the Aharonov-Bohm effect. @S1050-2947~98!06202-7# PACS number~s!: 32.80.Rm, 42.50.Hz, 03.65.Bz, 03.75.Dg An experiment has recently been performed showing that it is possible to generate an electron with radially dual spatial nature, namely, localized at two places at the same time @1#. This new experimental method makes it possible to observe interference fringes between two ‘‘parts’’ of a single electron analogous to those observed in a macroscopic Young experiment. This state is a coherent superposition of two radially confined electron wave packets that later spread and revive as a result of the nonlinearity of the Coulomb spectrum @2,3#. The influence of magnetic flux on electron interference has been a subject of both experimental and theoretical studies for many years @4#. These have been studies of the Aharonov-Bohm ~AB! effect @5,6# as well as of a direct influence of the magnetic flux on the physical properties of the quantum system when the magnetic field itself is also present @4,7#. Both macroscopic and mesoscopic systems have been the subject of those studies @8#. The common characteristic feature of this influence is that the physical quantities of the system depend periodically on the magnetic flux that passes through the system with a period related to the quantum of the magnetic flux h/2e. In the following we study numerically quantum states of hydrogen in linearly polarized electromagnetic and magnetic fields. We construct these states as coherent superpositions of well localized states in a circularly polarized field called Trojan wave packets @9‐11#. They can be used in an experiment analogous to the one reported in @1# but with an addition of a weak magnetic field. We present the results of numerical simulations that show that the presence of the magnetic flux leads to Aharonov-Bohm oscillations of the electron probability density as well as magnetic field oscillatory dependence of differential cross section for ultrashort half-cycle pulse ionization. It has been shown theoretically @9,10# that it is possible to generate and control the time evolution of a quantum state of hydrogen, whose probability density represents a well localized wave packet in three spatial dimensions moving around a classical circular orbit @12# without dispersion. In the laboratory frame this state is a time-dependent solution of the
The effect of the repeal of helmet use laws on motorcycle fatalities

As motorcycles have become more popular over the last two decades, motorcycle related deaths have risen. Methods to reduce fatalities have originated in both the private and public sector. The most ambitious of the public sector attempts to promote safety were the helmet use laws. The empirical results of this study indicate a significant relationship between the lack of a helmet use law and an increase in the fatality rate. Although a rider may ride more carefully when not wearing a helmet, this study indicates that this care is offset by the lack of crash protection provided by a helmet. Thus, at least for the years 1976–1979, one cannot reject the hypothesis that motorcycle helmet use laws have saved lives.
Active efflux of the free acid form of the fluorescent dye 2',7'-bis(2-carboxyethyl)-5(6)-carboxyfluorescein in multidrug-resistance-protein-overexpressing murine and human leukemia cells.

Murine and human cell lines overexpressing the multidrug-resistance protein (MRP) showed a marked decreased accumulation of the fluorescent dye 2′,7′-bis(2-carboxyethyl)-5(6)-carboxyfluorescein (BCECF). In contrast, less altered accumulation was seen in the P-glycoprotein(P-gp)-overexpressing cell lines. The decreased drug accumulation was reversed by the energy inhibitors sodium azideI2-deoxyglu-cose and by the vinca alkaloid, vincristine, but not by the chemotherapeutic agents, etoposide and adriamycin. Decreased accumulation was linked to active efflux of the hydrophilic free acid form of BCECF from the MRP-overexpressing cell lines, indicating that dye extrusion occurs after the dye ester has been converted to the free acid form in the cytoplasm. The finding suggests that MRP mediates removal of substrates from a cytoplasmic location. Buthionine sulfoximine (BSO), an inhibitor of glutathione synthesis, decreased the vincristine and etoposide resistance displayed by the MRP-expressing murine cell lines, but did not affect the accumulation of BCECF. Thus, while glutathione may be involved in MRP-mediated resistance to some chemotherapeutic agents, it is not necessary for efflux of substrates such as BCECF.
Entrepreneurship Education: Correspondence Between Practices of Nascent Entrepreneurs and Textbook Prescriptions for Success

Entrepreneurship courses are vital components of a business school curriculum. Although existing studies examine teaching pedagogy, very few explore the content of entrepreneurship courses. We comp...
A note on centralized regulatory review

Viewing the apparatus of the state as a vehicle through which regulators dispense wealth in return for political support, the well-known 'capture' theory implies that concentrated interests will generally prevail over more diffuse interests. In this note we argue that an important consideration in predicting regulatory outcomes in such a setting is the degree to which the overall administration of rent-seeking opportunities is centralized within a particular level of government.' If regulatory administration is decentralized, with rules issued piecemeal by a variety of independent agencies, then concentrated interests will typically be more successful in inducing regulators to fashion their decisions to benefit them. In contrast, a centralized review process makes this outcome less likely. The major benefit of centralized regulatory oversight is its effect on the rate of return to lobbying, or the attempt to capture an agency. Creating a central location for the review of proposed rules effectively sums the welfare costs associated with the gamut of individual regulations. In consequence, the expected benefits of lobbying by diffuse interests are increased, and more efforts by them to influence regulatory outcomes are predicted, ceteris paribus. By contrast, while centralized regulatory review should have little influence on the benefits realized by concentrated interests in lobbying for regulatory gains, their lobbying costs will rise. The change in the relative rates of return would appear large, and we would expect centralization to introduce substantially more influence by diffuse interests into the regulatory process, even if the supply elasticity of such lobbying effort is relatively low.
Senior citizens benefit from movement therapy

Abstract Sixteen senior citizens participated in four, 50-min movement therapy sessions over a 2-week period and were compared to 16 senior citizens who belonged to a wait list control group who received the movement sessions only after the end of the study. The movement therapy participants improved in their functional motion on the Tinetti scale, and specifically on the gait scale, their leg strength increased, and their leg pain significantly decreased.
Abstract 1540: TNFRs shed by tumor cells inhibit the migration of macrophages.

Breast tumor cells transform their microenvironment through the expression of pro-tumor molecules critical to their progression and metastasis. Among the targets of tumor cell secretions are macrophages, which play an essential role in tumor progression. Although macrophages possess tumor cell killing abilities, the tumor-associated macrophages (TAMs) display primarily pro-tumor functions including increasing tumor angiogenesis and promoting tumor cell invasion. Breast tumor cells shed multiple membrane-bound proteins including their tumor necrosis factor (TNF) receptors through TACE/ADAM17 activities. The release of sTNFR1/2 serves a decoy sequestering TNF and preventing TNF-driven apoptosis of tumor cells. Additionally, tumor derived sTNFR1/2 also modulate TNF effects on macrophages including their migration. Here, we investigated whether sTNFRs were shed by cells present within the breast tumor microenvironment and determined their effects on macrophage migration in response to TNF. TNF and sTNFRs concentrations were measured in murine mammary tumor and normal cells including monocytes/macrophages. In addition, the migration of murine monocytes toward TNF in the presence tumor derived soluble factors (TDSFs) was determined by transwell assays. The effects of TDSFs obtained with and without the sheddase inhibitor TAPI-0 treatment on monocyte/macrophage migration were also assessed. No TNF was detected in the TDSFs of tumor cells or secretions from normal epithelial cells. In contrast, stroma cells especially macrophages expressed high levels of TNF (p [This works is supported by grants from the Department of Defense Era of Hope research program (BC044778) and the National Science Foundation EFRI program (CBE0736007)]. Citation Format: Stephen Rego, Rachel Helms, Alexander De Piante, Amritha Kidiyoor, Amanda Lance, Pinku Mukherjee, Didier Dreau. TNFRs shed by tumor cells inhibit the migration of macrophages. [abstract]. In: Proceedings of the 104th Annual Meeting of the American Association for Cancer Research; 2013 Apr 6-10; Washington, DC. Philadelphia (PA): AACR; Cancer Res 2013;73(8 Suppl):Abstract nr 1540. doi:10.1158/1538-7445.AM2013-1540
Structure and properties of 9,10,11,12,13,14-hexahydro-9,10[1′,4′]-benzenoanthracene and 9,10,11,12,13,14,15,16-octahydro-9,10[1′,4′]-benzenoanthracene

Abstract The title compounds were prepared by 4 π s + 4 π s photochemical cycloaddition between anthracene and 1,3-cyclohexadiene, followed by catalytic hydrogenation. The results confirm the structure of the initial cycloadduct, 9,10,11,12,13,14-hexahydro-9,10[1′,4′]-benzenoanthracene ( 1 ), which in the crystal exhibits positional disorder about the cyclohexadiene-derived fragment that is only partially resolved. The origin of the disorder is considered in light of the crystallographic packing interactions and compared with intermolecular contacts in the hydrogenated derivative, 9,10,11,12,13,14,15,16-octahydro-9,10[1′,4′]-benzenoanthracene ( 2 ), which is not disordered. The asymmetric unit of 2 contains one-half of a molecule situated about a two-fold symmetry axis. Both structures contain relatively long interannular bonds between the bridgehead carbons of the anthracene- and cyclohexadiene-derived fragments, in agreement with ab initio calculations and considered in terms of bond strain in the carbon framework of these compounds.
The Framed Houses of Massachusetts Bay, 1625-1725

In a rich blend of architectural and social history, Abbott Lowell Cummings reconstructs some of our nation's first houses. This is a splendid story of innovations, of restless, migratory people and their architectural and social responses to their environment. It is the first chapter in the long saga of America's preoccupation with technology, showing how it affected the early American home.
Blue satellite bands of Rb broadened by noble gases

Measurements are presented for the blue-wing satellite bands of the Rb first resonance line (780 nm) emitted in the presence of the noble gases Ne, Ar, Kr, and Xe. The continuum intensity per spectral interval and perturber density is expressed as a fraction of the total Rb (780 nm) fluorescence from optically thin vapor. Over the \ensuremath{\sim}${10}^{18}$-${10}^{19}$ ${\mathrm{cm}}^{3}$ density range investigated this normalized satellite-peak intensity is found to scale linearly with perturber density and approximately exponentially in $\frac{\ensuremath{-}1}{T},T$ being the absolute temperature. In the classically forbidden region beyond the satellite peak the intensity drops exponentially with frequency for Xe perturbers, but departs from exponential behavior in the Ar and Kr data. We observe undulations in the spectra between line center and the satellite. This is expected due to the possibility of interference between contributions to the transition probability at two internuclear separations, the separations at which the difference potential equals the photon energy.
Analysis of Optically Induced Fluid Flows in Electric Fields

In this paper we demonstrate opto-electrothermal pumping in a very simple setup consisting primarily of parallel electrodes and explore the characteristics of such flows with different optical intensity patterns. For our parallel electrode configuration setup, ITO-coated electrodes were used to generate electric fields. The optical illumination system uses a laser beam (continuous wave, 1,064 nm). The experiments are analyzed in terms of existing analytical models for electrothermal flows. Microvortices created using the electric field and focused laser beam resembles a sink/source type flow with the laser spot as the center of the sink/source. The flow velocity is characterized as a function of the AC signal frequency and the strength of electric field. At larger frequencies (f > 1 MHz), the velocity of the vortices decreases and around f > 5 MHz, Brownian motion dominates fluid flow. The line illumination is created by holographically stretching the point illumination. The line is about 28 μm in length. Result of this experiment is determined by means of visualization only. The creation of these vortices can not only be used to create microfluidic pumps but also also show immense promise as microfluidic mixers without utilizaing any invasive components.© 2008 ASME
A Global Expression Switch Marks Pachytene Initiation during Mouse Male Meiosis

Male spermatogenesis is an essential and complex process necessary to gain totipotency and allow a whole new organism to develop upon fertilization. While single-gene based studies have provided insights into the mechanisms underlying spermatogenesis, detailed global profiling of all the key meiotic stages is required to fully define these processes. Here, by isolating highly enriched mouse meiotic cell populations, we have generated a comprehensive gene expression atlas of mammalian meiosis. Our data define unique signatures for the specific stages of meiosis, including global chromosome X inactivation and reactivation. The data also reveal profound switches in global gene expression at the initiation of pachynema that are reminiscent of the commitment to meiosis observed in budding yeast. Overall, this meiotic atlas provides an exhaustive blueprint and resource for mammalian gametogenesis and meiosis.
The Idea of Literary History in the Art Poétique of Boileau

(1964). The Idea of Literary History in the Art Poetique of Boileau. Symposium: A Quarterly Journal in Modern Literatures: Vol. 18, No. 3, pp. 264-272.
SUSCEPTIBILITY TO HYPNOSIS AND T.A.T. CARD 12M.

(1964). Susceptibility to Hypnosis and T.A.T. Card 12M. American Journal of Clinical Hypnosis: Vol. 6, No. 3, pp. 208-210.
Congenital corrected transposition of the great vessels without cardiac anomalies.

Abstract The clinical, angiocardiographic, vectorcardiographic and phonocardiographic findings in a fifty-four year old man with uncomplicated corrected transposition of the great vessels are presented. A soft, grade 26 precordial systolic murmur was present, and the second heart sound at the base appeared single on auscultation but was normally and narrowly split on phonocardiogram. The P-R interval was prolonged and paroxysmal nodal tachycardia frequently occurred. The patient never manifested any evidence of heart failure and the inverted ventricles functioned well with their reversed pressure and volume loads. Sixteen well documented cases of uncomplicated corrected transposition have been reported in the American literature, and the available clinical data on seven of these cases are reviewed. The present patient is the only one in the older age group with complete antemortem documentation of all cardiovascular parameters.
Genomic analysis of neural crest induction.

The vertebrate neural crest is a migratory stem cell population that arises within the central nervous system. Here, we combine embryological techniques with array technology to describe 83 genes that provide the first gene expression profile of a newly induced neural crest cell. This profile contains numerous novel markers of neural crest precursors and reveals previously unrecognized similarities between neural crest cells and endothelial cells, another migratory cell population. We have performed a secondary screen using in situ hybridization that allows us to extract temporal information and reconstruct the progression of neural crest gene expression as these cells become different from their neighbors and migrate. Our results reveal a sequential `migration activation' process that reflects stages in the transition to a migratory neural crest cell and suggests that migratory potential is established in a pool of cells from which a subset are activated to migrate.
Comparing Putters with a Conventional Blade and a Cylindrically Shaped Clubhead

Strmmay -A putter with a cylindrically shaped clubhead was tested and scores of 107 students (80 men and 27 women) in six college golf classes compared with those made w~th rl putter having a conventional blade clubhead. A nine-hole Bermuda grass putting green, with holes ranging in distance from 4 to 25 ft., was used. An analysis of variance of mean total putting scores showed that there was no significant daerence in putting scores with the two styles of putters on short, medium, or long putts, or on over-au scores. In golf, an improved short game-pitching, chipping, and putting-is widely accepted as the best way to improve golf scores (Wiren, 1992). Of these three short areas, putting was said to be most important in scoring at the 1995 National Golf Foundation's conference. Estimates in the literature range from 38% to 43% of all strokes taken are putting strokes (Wiren, 1992; Pelz, 1995). Literature on golf has often focused on improving the stroke technique of golfers. Recent attention has focused on the grip style or the method of holding the club. In a departure from the most common or standard style of a reverse overlap grip and in seeking greater stroke consistency, a number of professional golfers have changed to putting cross-handed. Others have tried putting one-handed, split-handed, and even anchoring the club's handle against the target forearm. Equipment manufacturers, however, have been intent on improving club design, adhering to the legal guidelines established by the United States Golf Association (USGA), the body governing golf equipment sold in the United States. In the last twenty years, the golf industry has made rapid advances both in design and material technology. Club shahs, constructed from various forms of graphite, titanium, and lightweight steel to make them lighter and more resistant to torque, and clubheads made from these same materials and in various sizes to make them easier to swing have made it difficult for consumers to stay abreast of changes. However, consumers have been more than willing to spend bdbons of dollars during this period to "buy a better game" (Purkey, 1995). Recognizing this mindset, manufacturers are constantly striving to design, develop, and produce new equipment.
Introduction to GPSS

Summary information about key aspects of the simulation programming language GPSS is provided. The class of problems to which GPSS applies especially well is described; commentary on the semantics and syntax of the language is offered; the learning-oriented literature for GPSS is summarized; various GPSS implementations are commented on; the time-sharing networks offering GPSS are cited; and public courses on the language are listed. Finally, the source of a tutorial introduction to the fundamental semantics and syntax of GPSS is given. Copies of this tutorial material, excluded from reproduction here because of page-count limits, will be distributed at the session and provide the basis for the session itself.
Effect of intensive endurance training on lipoprotein profiles in young and older men.

Abstract Although there are considerable data concerning the effects of endurance exercise training (ET) on plasma lipoproteins, the results have been quite inconsistent. The observed variability of response may be related to the age, sex, adiposity, or diet of the subjects tested, or to the type and intensity of the exercise intervention. Furthermore, there is relatively little such data in older individuals. Therefore, in the present study, we investigated the effects of intensive ET on lipoprotein profiles in healthy young (n = 12; 28.2 ± 2.4 years) and older (n = 15; 67.5 ± 5.8 years) men. Unlike subjects in most similar studies, our subjects were weight-stabilized on a constant-composition diet for 21 days prior to determination of the lipoprotein profile before and after the ET program. At baseline, the two groups were not significantly different with respect to any individual component of their lipoprotein profiles, relative weight, or percent body fat, but the older men had a more central distribution of fat by both waist to hip ratio (WHR) and computed tomography (CT). Maximal aerobic power, expressed per kilogram of body weight (VO2 max), was 33% lower (P
Drinking Patterns, Gender and Health III: Avoiding vs. Seeking Healthcare.

Background: Inability to predict most health services use and costs using demographics and health status suggests that other factors affect use, including attitudes and practices that influence health and willingness to seek care. Alcohol consumption has generated interest because heavy, chronic consumption causes adverse health consequences, acute consumption increases injury, and moderate drinking is linked to better health while hazardous drinking and alcohol-related problems are stigmatized and may affect willingness to seek care.Methods: A stratified random sample of health-plan members completed a mail survey, yielding 7884 respondents (2995 male/4889 female). We linked survey data to 24 months of health-plan records to examine relationships between alcohol use, gender, health-related attitudes, practices, health, and service use. In-depth interviews with a stratified 150-respondent subsample explored individuals’ reasons for seeking or avoiding care.Results: Quantitative results suggest health-rela...
Distribution of Fibrinogen, and Platelet Factors 4 and XIII in Subcellular Fractions of Human Platelets

Summary. The distribution of fibrinogen, platelet factor 4 (heparin-neutralizing factor) and factor XIII amongst subcellular fractions of human platelets was determined. It was found that fibrinogen and platelet factor 4 peaked sharply in the region of the density gradient previously shown to be heavily enriched with α-granules. By contrast, factor XIII, fibrin-stabilizing factor, was found exclusively in the supernatant.
Parallel β-sheet vibrational couplings revealed by 2D IR spectroscopy of an isotopically labeled macrocycle: quantitative benchmark for the interpretation of amyloid and protein infrared spectra.

Infrared spectroscopy is playing an important role in the elucidation of amyloid fiber formation, but the coupling models that link spectra to structure are not well tested for parallel β-sheets. Using a synthetic macrocycle that enforces a two stranded parallel β-sheet conformation, we measured the lifetimes and frequency for six combinations of doubly 13C═18O labeled amide I modes using 2D IR spectroscopy. The average vibrational lifetime of the isotope labeled residues was 550 fs. The frequencies of the labels ranged from 1585 to 1595 cm–1, with the largest frequency shift occurring for in-register amino acids. The 2D IR spectra of the coupled isotope labels were calculated from molecular dynamics simulations of a series of macrocycle structures generated from replica exchange dynamics to fully sample the conformational distribution. The models used to simulate the spectra include through-space coupling, through-bond coupling, and local frequency shifts caused by environment electrostatics and hydrogen...