cssi/SciSciGPT-SciSciNet huggingface dataset:
Determination of the levels of urokinase and its receptor in human colon carcinoma cell lines

At present, there is a lack of availability of differentiation markers for colon carcinoma. This may, in part, be a consequence of the diversified function of the normal human colon. This study addresses the possibility that the expression of urokinase and its receptor is inversely related to differentiation in colon carcinoma. Six colon carcinoma cell lines including three well-differentiated (CBS, GEO, FET) and three poorly differentiated ones (HCT116, HCT116b, RKO) were screened for urokinase receptor display and secretion of the plasminogen activator. A radioreceptor assay was used to determine receptor levels. Binding of radioactive urokinase to colon cells was saturable, specific, and time dependent. Cell-bound 125I-labeled protease was unaffected by the presence of epidermal growth factor, low-molecular-weight urokinase, plasminogen, or transferrin. Time course studies revealed that maximum amounts of radioactive tracer were bound in a 30-min period with no change occurring over the course of a 90-min incubation. Scatchard analysis of ligand binding indicated that the well-and poorly differentiated cells could be separated on the basis of receptor display; the aggressive RKO, HCT116, and HCT116b expressed in excess of 10(5) sites per cell, while the more indolent CBS, GEO, and FET possessed less than 1.5 X 10(4) receptors per cell. The colon carcinoma cells were also analyzed for urokinase in the conditioned medium. Low levels of the plasminogen activator (0.8 to 1.3 ng/ml/10(6) cells/72 h) were associated with the more "mature" cells. This was in contrast to the elevated levels of the protease (3.9 to 11.4 ng/ml/10(6) cells/72 h) present in the medium derived from the more aggressive cells (HCT 116, HCT116b, RKO). Thus, secreted urokinase and/or the expression of cellular receptor for the plasminogen activator may provide useful measurements of the degree of undifferentiation of in vitro colon carcinoma.
Immune function in mania

There is now a large body of evidence suggesting a close interaction between the central nervous system and the immune system. More specifically, immunological abnormalities have been described in relation to psychological stress (Jemrnott and Locke 1984) and in patients with psychiatric illness (DeLisi and Crow 1986). We have earlier reported a decrease in mitogen-induced lymphocyte proliferation in hospitalized depressed patients compared to normal controls (Kronfol et al. 1983). These findings have been replicated by independent investigators (Schleifer et al. 1984). Negative life events and depression have been associated with immunological impairment, as evidenced by decreased responsivity to mitogen stimulation and reduced natural killer cell activity (Bartmp et al. 1977; Locke et al. 1984). On the other hand, to the best of our knowledge, the immune status of patients with manic illness has never been investigated. We now report an impairment in immune regulation in manic patients similar to what has been described in patients with major depression. Subjects
Automated correlation discovery for semi-structured business processes

In this paper we describe an algorithm to automatically detect correlation identifiers from arbitrary data sources. Correlation identifiers can be useful for determining relationships between data in order to isolate instances of a running business process for the purposes of process monitoring and discovery. We have implemented our algorithm and validate our approach on a simulator that implements a real-world inspired order management case scenario consisting of 24 activities and corresponding event types. This simulated scenario involves a wide range of heterogeneous systems (e.g. Order Management, Document Management, E-Mail, and Export Violation Detection Services) as well as workflow-supported human-driven interactions (Process Management System). Initial results indicate that our approach is promising due to its demonstrated success in distinguishing correlations on data generated by our simulator executions. Our work also highlights the directions we could explore in future work such as distributed statistics calculation, and scalability in terms of handling massive data sets.
Periosteal and galeal adhesiveness after a forehead lift in a rodent model

Abstract Purpose: The aim of this study was to determine the strength of periosteal and galeal adhesiveness at particular intervals after subperiosteal and subperiosteal-subgaleal forehead lifting in a rodent model. Materials and Methods: Sixty mice underwent a subperiosteal or subperiosteal-subgaleal coronal forehead lift procedure. Necropic and histologic examination of the periosteal, galeal, and bone interface was performed on postoperative days 2, 4, 6, 8, and 10, and the strength of the elevated flap reattachment to underlying tissues was measured. Results: Tension analysis in the early postoperative period showed a higher avulsive force was required to re-elevate subgaleal-subperiosteal flaps than subperiosteal flaps. However, subperiosteal flap adhesiveness appeared to increase rapidly between postoperative days 4 and 8. By day 10, the force required to re-elevate subperiosteal flaps was significantly higher than that required for subgaleal-subperiosteal flaps (P ≤ .0001). Histologic analysis showed an inflammatory response at the periosteum-bone interface, which maximized at postoperative day 6. Conclusions: In the early postoperative period, subgaleal-subperiosteal flaps had higher adhesiveness than subperiosteal flaps. However, by postoperative day 10, subperiosteal forehead flaps were substantially more adherent in this rodent model.
Of Population and False Hopes: Malthus and His Legacy

This essay which analyses the contribution made by Malthus opens by describing the intellectual context offered by the late 18th and early 19th centuries when scientific discoveries and technological advances inspired some thinkers to envision utopia. Malthus wrote his first treatise on population to further a debate with his father. In his essay Malthus elaborated on the ideas of other thinkers about the limits of subsistence and population increase to reveal their socioeconomic implications. Malthus could envision no human means that would prevent population from growing faster than its means of subsistence and he disputed the perfectibility of man or human society. Because of his essay Malthus was appointed professor of political economy at a college in Hertfordshire and spent the rest of his life revising his first effort and publishing another major work. Malthus believed that charity could have a detrimental effect on poverty and that the impoverished would be better served if they were given an opportunity to work or an education. He argued that initiatives to alleviate a problem could exacerbate it if they were based on an inadequate understanding. Malthus affected other thinkers such as Darwin and Wallace Herbert Spencer and Marx (who deplored Malthuss ideas) and blazed a trail of influence into the 20th century. The continued existence of the two opposing views that science can solve all problems and that poverty can not be eliminated may reflect a difference of predisposition rather than the force of reason. The impending crisis caused by unchecked consumption of nonrenewable resources and population growth is of such magnitude today that few are willing to accept its inevitability.
A US Court Issues Formalistic Ruling on Reverse-Payment Settlements After 'Actavis' (GlaxoSmithKline/Teva Pharmaceuticals/Louisiana Wholesale Drug Company/King Drug Company)

In FTC v. Actavis, the Supreme Court held that a brand firm's payment to a generic to delay entering the market could violate the antitrust laws. In one of the first post-Actavis decisions, the New Jersey district court in In re Lamictal Direct Purchaser Antitrust Litigation issued a narrow, formalistic ruling on the question of what constitutes a payment.In the settlement at issue, GlaxoSmithKline agreed (in what is known as a no-authorized-generic provision) not to launch its own generic version of epilepsy- and bipolar-disorder-treating Lamictal during Teva’s 180-day exclusivity period, which the Hatch-Waxman Act reserves for the first generic to challenge a brand firm’s patent.This short article highlights two flaws in the opinion. First, the ruling was formalistic in concluding that Actavis was limited to cash payments. And second, the court invoked Actavis’s “five considerations” (which explained why antitrust immunity was not appropriate) as defenses the settling parties could offer.The article concludes that future courts would benefit from more directly focusing on the substance of brand conveyances to generics and more carefully following the Supreme Court’s guidance.
QuickResponseHost: Enabling crowdsourced disaster response stations

Following a disaster, there are generally many volunteers willing and able to help those affected. While volunteers can quickly contribute in terms of donations and aid collection, their ability to help further is limited by the complexity of tasks. While technologies exist for volunteers to be able to set up and assist in disaster response data collection and management systems, they require a certain amount of technical knowledge which a large segment of volunteers may lack. Moreover, the need to learn such systems within a small time frame may pose a challenge if systems work and appear differently from those being used in day-to-day life. This paper presents QuickResponseHost, an information system that enables volunteers to quickly host their own disaster response systems and begin helping those nearby without having extensive technical knowledge. The interface of this system has been designed to make sure that the task of creating a response station is as simple as downloading an executable program. These distributed base stations allow volunteers to report injuries, missing reports, resources, etc. The stations function offline and synchronize data with a central server when connected. With an intentionally designed user interface and multiple layers of abstraction, QuickResponseHost makes any volunteer with a laptop computer capable of participating in the recovery process.
Further Beyond Zipf's Law: A Quadratic Model for the Frequency-Rank Distribution for the Brown Corpus and Other Commonly Available English Corpora

A quadratic extension to the Zipf-Mandelbrot Law is fitted to frequency-rank plots for a series of commonly available English language corpora: specifically the Brown, Reuters, Genesis, State of the Union and Movie Reviews corpora available in the Python Natural Language Tool Kit (NLTK) package. In all cases, a quadratic form for the Zipfian frequency-rank relationship is chosen as the best approximating model to the data over the simpler Zipf and Zipf- Mandelbrot Laws. A naive pseudoword set is generated by a bootstrap method to estimate the sampling distributions of the estimated parameters, from which we may conclude that the observed curvature of the frequency-rank plot is not consistent with an unordered random symbol concatenation method as described by Li. A relationship between the lexical diversity of the corpora, as estimated by the Guiraud Index of the relative frequency of types and tokens, and the ob- served curvature of the frequency-rank plot is present (although for the number of copora studied here the relationship is not significant).
Abstract WMP32: Immunomodulation and Neuroprotection by Progesterone in Infections following Ischemic Brain Injury in Middle-Aged Rats

Infection is one of the major complications during the acute phase following stroke, accounting for in-hospital deaths and worsening outcomes. We investigated the effect of delayed systemic inflamm...
Different arsenate and phosphate incorporation effects on the nucleation and growth of iron(III) (Hydr)oxides on quartz.

Iron(III) (hydr)oxides play an important role in the geochemical cycling of contaminants in natural and engineered aquatic systems. The ability of iron(III) (hydr)oxides to immobilize contaminants can be related to whether the precipitates form heterogeneously (e.g., at mineral surfaces) or homogeneously in solution. Utilizing grazing incidence small-angle X-ray scattering (GISAXS), we studied heterogeneous iron(III) (hydr)oxide nucleation and growth on quartz substrates for systems containing arsenate and phosphate anions. For the iron(III) only system, the radius of gyration (Rg) of heterogeneously formed precipitates grew from 1.5 to 2.5 (±1.0) nm within 1 h. For the system containing 10–5 M arsenate, Rg grew from 3.6 to 6.1 (±0.5) nm, and for the system containing 10–5 M phosphate, Rg grew from 2.0 to 4.0 (±0.2) nm. While the systems containing these oxyanions had more growth, the system containing only iron(III) had the most nucleation events on substrates. Ex situ analyses of homogeneously and heter...
Out of sight, out of mind: privy architecture and the perception of sanitation.

This study examines privy vault architecture, an often underutilized piece of archaeological evidence, to provide another line of evidence for understanding perceptions of sanitation in mid 19th to early 20th-century Louisville, Kentucky. Specific architectural attributes of privy vaults are analyzed in relation to ordinances that regulated the construction of these features. The vault depth, materials used in construction, method of construction, and their proximity to water sources are analyzed. This analysis reveals that misguided sanitary perceptions affected the ordinances pertaining to sanitary issues and the compliance of the ordinances by the public, which were manifested in the way privy vaults were constructed. The intention of this research is to demonstrate the utility of privy vault architecture as archaeological information and to illustrate the potential of interpreting archaeological data in specific contexts. By interpreting the same archaeological information in different contexts, we can begin to understand the multiple meanings of objects in the past, leading to a better understanding of past culture.
Amine-modified silica nanotubes and nanospheres: synthesis and CO2 sorption properties

Silica nanotubes (SNT) and silica nanospheres (SNS) were prepared in the presence of Pluronic F127 triblock copolymer. Post-synthesis grafting and co-condensation were used to introduce aminopropyl groups on the surface of SNT and SNS, respectively. Nitrogen adsorption was employed to evaluate the surface area and porosity of unmodified and modified SNT and SNS. These materials were tested for CO2 capture at ambient (25 °C) and elevated (120 °C) temperatures and showed high sorption uptakes (0.91–2.87 mmol g−1) at 120 °C. The CO2 uptakes obtained at 1.2 atm and 25 °C for SNT, SNS, and aminopropyl-modified SNT and SNS are 2.81, 2.06, 2.35, and 1.54 mmol g−1, respectively. The microporosity of the samples was shown to be beneficial for CO2 physisorption under ambient conditions, while basic amine groups were essential for enhancing CO2 chemisorption at elevated temperatures.
Determination of phenylbutazone residues in bovine milk by liquid chromatography with UV detection.

A published liquid chromatographic (LC) method was modified for quantitation of phenylbutazone (PBZ) residues in the range of 25-300 ng/mL in bovine milk. Milk samples (1 mL) were diluted with absolute ethanol and 25% NH 4 OH. Diethyl ether and petroleum ether were added sequentially to the milk extract and the mixture was agitated on a Vortex mixer to partition out milk fat. The organic phase was removed and discarded. Tetrahydrofuran-hexane (1 + 4) was added to the aqueous phase and the extract was acidified with 3M HCl. The samples were mixed on a Vortex mixer for 30 min, and centrifuged. The organic layer, containing PBZ, was transferred to a clean test tube. The organic solvents were evaporated to dryness under a stream of N 2 at room temperature. The resulting extract was dissolved in 1 mL mobile phase and filtered before injection. The chromatographic system was a C 18 reversed-phase column connected to a UV detector set at 264 nm. Recoveries of PBZ from raw bovine milk fortified at 25-300 ng/mL ranged from 79 to 84% ; relative standard deviations (RSDs) ranged from 6 to 7%. The RSDs for incurred PBZ quantitated from 34 to 229 ng/mL ranged from 1 to 4%.
Contributions to MMS and IFToMM from USA

Many of the important developments in mechanism and machine science of the past 50 years originated with work in the USA. In this chapter we will attempt to review the most significant of these. Space is limited, so some valuable topics cannot be addressed.
Penalties: Unintended Consequences of the Economic Substance Penalty

In 2010, Congress codified the economic substance doctrine and created a strict liability penalty for understatements attributable to transactions that did not have economic substance. Recent court decisions have refused to invalidate transactions based on economic substance and have focused instead on other doctrines such as sham transaction and substance over form. This may have implications for the strict liability penalty incorporated into the economic substance doctrine.
Fechner’s Distribution and Connections to Skew Brownian Motion

This note investigates two aspects of Fechner’s two-piece normal distribution: (1) connections with the mean-median-mode inequality and (strong) log-concavity; (2) connections with skew and oscillating Brownian motion processes. The developments here have been inspired by Wallis (Stat Sci 29:106–112, 2014) and rely on Chen and Zili (Sci China Math 58:97–108, 2015).
Stabilizing Controller Design for Multibus MVdc Distribution Systems Using a Passivity-Based Stability Criterion and Positive Feedforward Control

A power-electronics-based dc distribution system is a complex and extensively interconnected system consisting of multiple power converters. As a result, a number of system-level challenges related to stability arise due to interactions among multiple converter subsystems. The design of this type of system is difficult due to limited understanding of the problem and general lack of proper analysis tools for multibus systems. Conventional stability criteria, such as the Middlebrook criterion and its extensions, apply only to single-bus systems. This paper proposes a stability analysis and stabilizing controller design technique for multibus MVdc converter systems. First of all, an unterminated two-port modeling technique is used to construct the impedances of all system buses. Then, overall system stability is evaluated utilizing the recently proposed passivity-based stability criterion. In order to ensure good stability margin and dynamic performance, the new concept of an allowable impedance region is introduced based on the Nyquist contour of the bus impedance. Finally, a stabilizing controller is designed using a positive feedforward control technique to ensure passivity of the system buses, providing stability and good performance. Validation of the proposed techniques is provided through the simulation and experimental results.
Wetland shoreline recession in the Mississippi River Delta from petroleum oiling and cyclonic storms

We evaluate the relative impact of petroleum spill and storm surge on near-shore wetland loss by quantifying the lateral movement of coastal shores in upper Barataria Bay, Louisiana (USA), between June 2009 and October 2012, a study period that extends from the year prior to the Deepwater Horizon spill to 2.5 years following the spill. We document a distinctly different pattern of shoreline loss in the 2 years following the spill, both from that observed in the year prior to the spill, during which there was no major cyclonic storm, and from change related to Hurricane Isaac, which made landfall in August 2012. Shoreline erosion following oiling was far more spatially extensive and included loss in areas protected from wave-induced erosion. We conclude that petroleum exposure can substantially increase shoreline recession particularly in areas protected from storm-induced degradation and disproportionally alters small oil-exposed barrier islands relative to natural erosion.
Photovoltaics Program Overview

Since we last summarized the U.S. Photovoltaic Energy Systems status, a torrent of change has engulfed us, leading me to believe that there is no way to stop photovoltaics from becoming a pervasive, renewable energy source of electricity for houses, businesses, villages and central stations by 1985.
Respiratory rhythm generation: triple oscillator hypothesis.

Breathing is vital for survival but also interesting from the perspective of rhythm generation. This rhythmic behavior is generated within the brainstem and is thought to emerge through the interaction between independent oscillatory neuronal networks. In mammals, breathing is composed of three phases - inspiration, post-inspiration, and active expiration - and this article discusses the concept that each phase is generated by anatomically distinct rhythm-generating networks: the preBotzinger complex (preBotC), the post-inspiratory complex (PiCo), and the lateral parafacial nucleus (pF L), respectively. The preBotC was first discovered 25 years ago and was shown to be both necessary and sufficient for the generation of inspiration. More recently, networks have been described that are responsible for post-inspiration and active expiration. Here, we attempt to collate the current knowledge and hypotheses regarding how respiratory rhythms are generated, the role that inhibition plays, and the interactions between the medullary networks. Our considerations may have implications for rhythm generation in general.
Unraveling biophysical interactions of radiation pneumonitis in non-small-cell lung cancer via Bayesian network analysis.

Abstract Background In non-small-cell lung cancer radiotherapy, radiation pneumonitis≥grade 2 (RP2) depends on patients' dosimetric, clinical, biological and genomic characteristics. Methods We developed a Bayesian network (BN) approach to explore its potential for interpreting biophysical signaling pathways influencing RP2 from a heterogeneous dataset including single nucleotide polymorphisms, micro RNAs, cytokines, clinical data, and radiation treatment plans before and during the course of radiotherapy. Model building utilized 79 patients (21 with RP2) with complete data, and model testing used 50 additional patients with incomplete data. A developed large-scale Markov blanket approach selected relevant predictors. Resampling by k -fold cross-validation determined the optimal BN structure. Area under the receiver-operating characteristics curve (AUC) measured performance. Results Pre- and during-treatment BNs identified biophysical signaling pathways from the patients' relevant variables to RP2 risk. Internal cross-validation for the pre-BN yielded an AUC=0.82 which improved to 0.87 by incorporating during treatment changes. In the testing dataset, the pre- and during AUCs were 0.78 and 0.82, respectively. Conclusions Our developed BN approach successfully handled a high number of heterogeneous variables in a small dataset, demonstrating potential for unraveling relevant biophysical features that could enhance prediction of RP2, although the current observations would require further independent validation.
Breaking Bad News in Veterinary Medicine

The patient-provider relationship in the context of veterinary medicine represents a unique opportunity for studying how bad news is communicated to pet owners by conducting structured interviews with veterinarians. A sample of 44 veterinarians' responses was recorded and content-analyzed in an effort to identify themes among providers in their clinical experience of breaking bad news (BBN). Two coders revealed several themes in the data that were organized by three overarching areas: (1) breaking bad news in general, (2) euthanasia, and (3) social support. The findings from interviews indicated the COMFORT model (Villagran, Goldsmith, Wittenberg-Lyles, & Baldwin, 2010) in medical education provided a useful framework to organize the communication of BBN in veterinary medicine. Results were discussed in relation to future research in patient-provider communication and COMFORT's potential value for training students in veterinarian education.
An Alternative Stiction-modelling Approach and Comparison of Different Stiction Models

Due to the adverse impact of valve stiction in the process industry, both physical models and empirical data-driven models have been developed in the past decade to investigate the valve-stiction behaviour. Chapter 2 presented two data-driven models: Choudhury’s model and Kano’s model. In this chapter, we focus on another data-driven modelling approach (i.e. He’s model).We compare different data-driven models against a well-established physical model. The comparison is carried out in several aspects, including model assumptions, valve signatures generated by the models, and closed-loop behaviour when valve models are included in a closed-loop system. A new data-driven model is proposed based on a thorough analysis of the physical model and its effectiveness in simulating valve stiction is demonstrated.
Immediate effects of diaphragmatic myofascial release on the physical and functional outcomes in sedentary women: A randomized placebo-controlled trial

Abstract Background Although diaphragmatic myofascial release techniques are widely used in clinical practice, few studies have evaluated the simultaneous acute effects of these techniques on the respiratory and musculoskeletal systems. Objective To evaluate the immediate effects of diaphragmatic myofascial release in sedentary women on the posterior chain muscle flexibility; lumbar spine range of motion; respiratory muscle strength; and chest wall mobility. Design A randomized placebo-controlled trial with concealed allocation, intention-to-treat analysis, and blinding of assessors and participants. Participants Seventy-five sedentary women aged between 18 and 35 years. Intervention The sample was randomly allocated into one of two groups; the experimental group received two diaphragmatic myofascial release techniques in a single session, and the control group received two placebo techniques following the same regimen. Outcomes measures The primary outcome was chest wall mobility, which was analyzed using cirtometry. The secondary outcomes were flexibility, lumbar spine range of motion, and respiratory muscle strength. Outcomes were measured before and immediately after treatment. Results The manual diaphragm release techniques significantly improved chest wall mobility immediately after intervention, with a between-group difference of 0.61 cm (95% CI, 0.12–1.1) for the axillary region, 0.49 cm (95% CI, 0.03–0.94) for the xiphoid region, and 1.44 (95% CI, 0.88–2.00) for the basal region. The techniques also significantly improved the posterior chain muscle flexibility, with a between-group difference of 5.80 cm (95% CI, 1.69–9.90). All movements except flexion of the lumbar spine significantly increased. The effects on respiratory muscle strength were non-significant. Conclusion The diaphragmatic myofascial release techniques improve chest wall mobility, posterior chain muscle flexibility, and some movements of the lumbar spine in sedentary women. These techniques could be considered in the management of people with reduced chest wall and lumbar mobility. Trial registration NCT03065283.
Implied Volatility Comovement and the Information Content of Insiders’ Trades

Prior literature exploits option implied volatility to extract information about expectations of future information arrival intensity. We explore relations across implied volatilities, in contrast to the prior literature’s focus on implied volatilities of individual firms or indices. We investigate implied volatility comovement, IVC, the comovement between a firm’s implied volatility and the implied volatility of the market index. We hypothesize that IVC reflects the extent to which firm managers’ private information is informative about future aggregate equity returns. Using insider purchase intensity as a proxy for firms’ private information, we find that the association between insider purchases and future unexpected market returns significantly increases with IVC. Further, firms with higher IVC have stock returns that are more informative about future aggregate earnings and have stronger aggregate market reactions to their earnings announcements. This suggests that a firm’s implied volatility embeds important information about the nature of private information generated inside the firm.
The Absaroka Sequence: Lower Pennsylvanian—Lower Jurassic

The Absaroka Sequence was deposited through the longest of Phanerozoic geological intervals to be considered in this book. It took more than three geological periods (Pennsylvanian through Early Jurassic time) for the complete sequence to be laid down and, during these roughly 145 Myr., some fundamental changes occurred on Earth and on the continent. Among these changes were (1) assembly of Pangaea II, completed by the Permian Period, and the initial breakup of the global landmass during Triassic—Jurassic time; (2) the first sustained episode of nonvolcanic tectonic activity within the western craton; (3) the most prolonged interval of subaerial exposure of the craton in Phanerozoic time; (4) uniquely symmetrical and pervasive deposition of coal-bearing cyclical deposits during the Pennsylvanian and Permian Periods (also occurring on other continents); (5) appearance by latest Absarokan time of all known phyla of animals including all classes of vertebrates; (6) along with the above, appearance of a uniquely diverse arborescent flora and the first diverse terrestrial fauna; and (7) the most pervasive mass extinction event in the history of the marine biota, from which, it is claimed by some authors, less than 5% of all species of marine animals may have escaped!
Risk Aversion and Implicit Bias

This paper studies risk aversion as an influential construct in implicit bias testing, and one that has been previously overlooked in the literature. In it, I adapt a model of internal validity and apply it to the impact that risk preferences have on implicit bias. I then implement a laboratory experiment to gauge implicit bias as measured by the implicit association test (IAT). I structurally estimate subjects’ attitudes towards risk. In testing said model, I find that higher levels of risk aversion are associated with stronger implicit bias scores. This result is robust to a variety of econometric specifications and thus lends support to previous critiques of IAT validity.
A person-centred approach to understanding cultures of assessment

The purpose of the present study was to investigate how faculty members coalesce into distinguishable groups in terms of their perceived cultures of assessment at their respective institutions. To ...
A pragmatic evidence-based clinical management algorithm for burning mouth syndrome.

Background Burning mouth syndrome is a poorly understood disease process with no current standard of treatment. The goal of this article is to provide an evidence-based, practical, clinical algorithm as a guideline for the treatment of burning mouth syndrome. Material and methods Using available evidence and clinical experience, a multi-step management algorithm was developed. A retrospective cohort study was then performed, following STROBE statement guidelines, comparing outcomes of patients who were managed using the algorithm and those who were managed without. Results Forty-seven patients were included in the study, with 21 (45%) managed using the algorithm and 26 (55%) managed without. The mean age overall was 60.4 ±16.5 years, and most patients (39, 83%) were female. Cohorts showed no statistical difference in age, sex, overall follow-up time, dysgeusia, geographic tongue, or psychiatric disorder; xerostomia, however, was significantly different, skewed toward the algorithm group. Significantly more non-algorithm patients did not continue care (69% vs. 29%, p=0.001). The odds ratio of not continuing care for the non-algorithm group compared to the algorithm group was 5.6 [1.6, 19.8]. Improvement in pain was significantly more likely in the algorithm group (p=0.001), with an odds ratio of 27.5 [3.1, 242.0]. Conclusions We present a basic clinical management algorithm for burning mouth syndrome which may increase the likelihood of pain improvement and patient follow-up. Key words:Burning mouth syndrome, burning tongue, glossodynia, oral pain, oral burning, therapy, treatment.
Population-based treated prevalence, risk factors, and outcomes of bicuspid aortic valve in a pediatric Medicaid cohort

Background: We investigated the treated prevalence of bicuspid aortic valve in a pediatric population with congenital heart disease and its incident complications. Materials and Methods: A 15-year retrospective data set was analyzed. Selection criteria included age ≤17 years, enrollees in the South Carolina State Medicaid program and diagnosed as having bicuspid aortic valve on one or more service visits. Results: The 15-year-treated prevalence of predominantly isolated bicuspid aortic valve was 2% (20/1000) of pediatric congenital heart disease cases, with a non-African American: African-American ratio of 3.5:1, and a male:female ratio of 1.6:1. Aortic stenosis (28.0%), ventricular septal defect (20.6%), and coarctation of the aorta (20.6%) were the most prevalent coexisting congenital heart lesions. Of the 378 bicuspid aortic valve cases examined, 10.3% received aortic valve repair/replacement, which was significantly more likely to be performed in children with diagnosed aortic stenosis (adjusted odds ratio = 12.90; 95% confidence interval = 5.66–29.44). Cohort outcomes over the study period indicated that 9.5% had diagnosed heart failure, but Conclusions: The majority of isolated bicuspid aortic valve cases without aortic stenosis did not require surgical intervention. Outcomes for cases requiring repair/replacement were relatively benign.
Wearable Eye-tracking for Research: Automated dynamic gaze mapping and accuracy/precision comparisons across devices

Wearable eye-trackers offer exciting advantages over screen-based systems, but their use in research settings has been hindered by significant analytic challenges as well as a lack of published performance measures among competing devices on the market. In this article, we address both of these limitations. We describe (and make freely available) an automated analysis pipeline for mapping gaze data from an egocentric coordinate system (i.e. the wearable eye-tracker) to a fixed reference coordinate system (i.e. a target stimulus in the environment). This pipeline allows researchers to study aggregate viewing behavior on a 2D planar target stimulus without restricting the mobility of participants. We also designed a task to directly compare calibration accuracy and precision across 3 popular models of wearable eye-trackers: Pupil Labs 120Hz Binocular glasses, SMI ETG 2 glasses, and the Tobii Pro Glasses 2. Our task encompassed multiple viewing conditions selected to approximate distances and gaze angles typical for short- to mid-range viewing experiments. This work will promote and facilitate the use of wearable eye-trackers for research in naturalistic viewing experiments.
Adhesives Containing Pine Bark Tannin for Bonding Nylon Cord to Rubber

Purified loblolly pine bark tannin was studied as an additive in resorcinol-formaldehyde latex (RFL) adhesive dips for bonding nylon to a styrenebutadiene-rubber (SBR) vulcanizate. The viscosity of the adhesive and its bonding characteristics depended on the order in which ingredients were combined in adhesive preparation. Pre-dilution before combining reactive components led to increased viscosity, higher pullout forces, and prevention of precipitate formation when compared to the addition of water after mixing resorcinol, tannin, formalin, and NaOH (post-dilution). Viscosity increased as the resin solids content of the adhesive increased. Stress-strain measurements indicated an initial toughening of the adhesive as resorcinol was replaced by tannin, but at sufficiently high substitutions, a marked softening and reduction in toughness occurred. Pullout forces with nylon 66 cord were increased if the adhesive was applied without prior aging. Pullout forces could be optimized by varying the formaldehyde concentration and latex-to-resin ratio in the tannin-containing adhesives.
Communication skills in the CS curriculum

Over the years it has been pointed out that an important skill for computer science majors is the ability to communicate effectively [1, 3, 9]. Unfortunately, for a variety of reasons, computer science students often never acquire these skills [4]. This paper (a) considers some of the reasons why students do not acquire these skills, (b) reviews some approaches that have been proposed to remedy this situation, (c) presents an argument for defining what these skills are in a more comprehensive manner, and (d) describes how these communication skills can be integrated into a computer science curriculum.
Oxytocin alterations and neurocognitive domains in patients with hypopituitarism

Oxytocin is a hypothalamus derived, posterior pituitary stored nonapeptide which has gained recent interest as an important neuropsychiatric and metabolic hormone beyond its classic role in lactation and parturition. Hypopituitarism is a heterogenous disorder of derangement in one or more anterior or posterior pituitary hormones. Diagnosis of deficiency and hormone replacement exists to address all relevant axes except for oxytocin. Our study aims to define derangements in oxytocin in a unique population of patients with hypopituitarism and correlate levels with measures of emotional health and quality of life. A cross-sectional, single day study was completed to measure plasma oxytocin levels in a diverse population of patients with hypopituitarism compared to controls. Subjects also completed depression, quality of life and stress-related questionnaires, and emotion recognition tasks. Thirty-eight subjects completed the study, 18 with hypopituitarism (9 with diabetes insipidus) and 20 controls. After controlling for differences in age, weight and gender, plasma oxytocin levels were highest in subjects with diabetes insipidus compared to control [mean, IQR: 44.3 pg/ml (29.8–78.2) vs. 20.6 (17–31.3), p = 0.032]. Amongst hypopituitary subjects, those with duration of disease greater than 1 year had higher oxytocin levels. No significant differences were observed for psychosocial measures including emotion recognition tasks. Plasma oxytocin levels were found higher in patients with hypopituitarism compared to controls and highest in those with diabetes insipidus. Longer duration of hypopituitarism was also associated with higher plasma levels of oxytocin. Further study is needed to better define oxytocin deficiency and investigate response to treatment.
Use of an Instrumented Timed Up and Go (iTUG) for Fall Risk Classification

Aim: To determine if an instrumented Timed Up and Go (iTUG) can accurately classify older adult recurrent fallers and non-fallers who are age and sex-matched. Methods: iTUG data from older adult re...
Doppler Recognition of Low or Normal Central Venous Pressure from Continuous Flow from Inferior Vena Cava Into Right Atrium

Estimation of right atrial (RA) or central venous pressure (CVP) is a critical component of a comprehensive transthoracic echocardiographic (TTE) examination. We hypothesize that continuous inflow from the inferior vena cava (IVC) into the RA is a surrogate for low/normal CVP and can be reliably imaged in standard echocardiographic parasternal short and right ventricular inflow views. We retrospectively studied 200 patients who underwent right heart catheterization (RHC) within 8 hours of TTE between 2012 and 2016, and selected 60 patients in whom the continuous wave Doppler beam incidentally interrogated IVC inflow into RA during evaluation of the tricuspid valve. From these studies, we sought an uninterrupted Doppler wave (DW) inflow signal. CVP on RHC were then compared in patients with continuous and interrupted DW. Other TTE and RHC parameters were also noted and compared in these 2 groups. The average time interval between TTE and RHC was 266 ± 151 minutes. Of 60 patients (males = 39 (65%); age 63 ± 14 years), 12 patients (20%) had continuous DW and 48 (80%) had interrupted DW inflow signal from IVC into the RA. Of the 12 patients with continuous flow, 11 had RA pressure of ≤7 mm Hg. Similarly, of 48 patients with interrupted flow, RA pressure was >7 mm Hg in 45, and less than ≤7 mm Hg in 3 patients (two-sided p value 0.0001). The continuous DW signal predicted RA of ≤7 mm Hg with a sensitivity and specificity of 98% and 78%, respectively. Additionally, when combined with IVC size and collapsibility (normal-sized collapsible IVC), the sensitivity and specificity of DW signal to predict RA of ≤ 7 mmHg were enhanced to 94% and 92%, respectively. In conclusion, IVC flow pattern can be reliably studied to estimate CVP in standard echocardiographic views. Continuous and interrupted IVC flow predicts normal and elevated RA pressure, respectively.
Abstract 4871: Comparative analysis of tumor treating fields using conventional versus alternative array placement for posterior fossa Glioblastoma

Background: Tumor Treating Fields (TTFields) therapy is an approved treatment modality for glioblastoma. Optimal transducer array placement can be defined by anatomy-based finite element analysis (FEA), which helps to delineate electric field coverage of the tumor. The conventional array placement was designed to provide adequate electric field coverage for supratentorial glioblastomas. There is an alternative array placement configuration for infratentorial tumors, but the extent of coverage to posterior fossa glioblastoma is unknown. Methods: Patient anatomy-based FEA models were created by segmenting MRI images — using the NewSegment algorithm from Statistical Paramedic Mapping 8 — into tissue “masks” utilizing ScanIP from Simpleware (Exeter, UK). The physical properties of each tissue type were first applied to these masks and then boundary conditions for physics modeling was set up within COMSOL Multiphysics (Burlington, MA). COMSOL generated electric field maps were compared for models using the conventional array placement configuration for supratentorial tumors versus the alternative array placement configuration for infratentorial tumors. Electric field-volume histograms (EVHs) and specific absorption rate-volume histograms (SARVHs) were constructed to numerically evaluate the relative and/or absolute magnitude volumetric differences between models. Results: The alternative configuration consists of array placement at the vertex, the bi-occipital regions and the upper neck. The highest EAUC was found at the epidural space surrounding the spinal cord and scalp for both types of configurations, whereas the lowest was located at the tongue and orbits. Using the conventional configuration, the gross tumor volume (GTV) had an electric field area under the curve (EAUC) of 40.5 V/m, volume covered with electric field intensity of 150 V/m (VE150) of 0.01%, 95% electric field intensity (E95%) of 30.9 V/m, E50% of 41.1 V/m, and E20% of 46.6 V/m. The GTV also had a SARAUC of 4.0 W/kg, volume covered with SAR of 6 W/kg (VSAR6) of 0%, SAR95% of 0.6 W/kg, SAR50% of 0.7 W/kg, and SAR20% of 0.8 W/kg. The alternative configuration produced EAUC of 52.3 V/m, VE150 of 3.6%, E95% of 29.1 V/m, E50% of 44.7 V/m, and E20% of 58.1 V/m, as well as SARAUC of 0.9 W/kg, VSAR6 of 0.3%, SAR95% of 0.6 W/kg, SAR50% of 0.8 W/kg, and SAR20% of 0.9 W/kg. Conclusions: The alternative array placement configuration provides a higher coverage of electric field (+29%) to the posterior fossa glioblastoma when compared to the conventional configuration. Citation Format: Edwin Lok, Pyay San, Victoria White, Eric T. Wong. Comparative analysis of tumor treating fields using conventional versus alternative array placement for posterior fossa Glioblastoma [abstract]. In: Proceedings of the American Association for Cancer Research Annual Meeting 2019; 2019 Mar 29-Apr 3; Atlanta, GA. Philadelphia (PA): AACR; Cancer Res 2019;79(13 Suppl):Abstract nr 4871.
Our Bodies and the Language We Learn: The Dialectic of Burkean Identification in the 1930s

Rhetorical scholars have long regarded identification as a concept central to Kenneth Burke’s work. However, a close reading of Burke’s work of the 1930s locates the early incarnations of identific...
P355 The transition of care from adolescents to adults: the diabetes model

Background The transition of diabetes care from adolescents to adult management remains a challenging filed due to many social, demographic and economic factors. During the transition phase, strong emphasis is placed on encouraging teens to begin self-care and self-management of their diabetes through guided practice of physical and practical skills needed for this transition. Method A registry system and plan were created to transition adolescent patients with both type 1 and 2 diabetes, starting at the age of 16.5, to adult endocrinology care when the patient turns 18 years old, when graduates from high school or if the female patient becomes pregnant at any time during pediatric endocrinology care. This transition plan includes Identifying and maximizing skills needed for successful self-management of diabetes, identifying barriers to successful transitions, creating a plan of interventions to help and encourage the young adult to continue receiving healthcare, collaborating with the adolescent in locating an adult care endocrinologist who will resume the care, providing teens with discharge of care prescription refills, any supplies needed and school/college instruction packets, and attempt four follow up phone calls to the patient during the transition phase after the patient has been discharged from pediatric care. Results Out of 160 patients (121 type 1 and 39 type 2 diabetes) who started the transition process with at least one visit completed, only 120 patients (75%) completed the process and were formally discharged from clinic. The remaining patients (25%) are still in the transition phase and currently being seen in clinic. We were able to make follow up appointments with adult endocrinologist for the 120 patients transitioned (100%) but only 60 patients documented presence for this follow up (50%). Conclusion The outcome of transition of diabetes care was faced by some obstacles; these can be grouped into: 1-Psychological factors: Adolescents burnt out, depression and adjustment disorders. Lack of Independence and readiness. 2-Factors affecting access to health care: Change of health care insurance, lack of insurance, lack of financial means to pay for visit; and transportation problems. 3- Communication factors: Inability to maintain contact after transition (patients not responding to communication from providers, disconnected phone number). Bridging the gaps in health insurance during this transitional period remains of great importance. Understanding the differences in learning styles between individuals in this transition period will also reflect the readiness for transition.Training health care professionals for this delivery of care is also crucial.
Learning How to be an Ethical Fashion Consumer

Teachers are challenged to help students figure out how to "do the right thing" - in the classroom, and professionals, and as consumers. This presentation provides an opportunity for reflection about how to guide students to be ethical consumers along with teaching competencies for professional roles in product development, distribution, and selling in the fashion industry.