cssi/SciSciGPT-SciSciNet huggingface dataset:
Proactive thermal management using memory based computing

Nanoscale devices provide the capability of gigascale integration in modern electronic systems. However, such systems suffer from high defect rates and large parametric variations. The surge of transistor count with the increased clock rate elevates the processor temperature which makes these systems even more unreliable and unstable. Dynamic Thermal Management (DTM) approaches considerably increase application's run-time in order to lower the peak temperature. Memory-based computing (MBC) is a promising approach to improve overall system reliability when few functional units are defective or unreliable under process-induced or thermal variations. In this paper, we present a novel DTM technique using proactive MBC to reduce the peak temperature of applications. We propose an efficient technique to proactively transfer the instructions with frequent operand pairs to memory. Experimental results demonstrate that the proposed proactive thermal management can significantly decrease the peak temperature to improve the system reliability with minor impact on performance.
On Risk-Based Design of Complex Engineering Systems: An Analytical Extreme Event Framework

In this work, a novel analytical framework is proposed for the risk-based design of complex engineering systems. The risk based-design process is the reverse process of risk propagation that entails the optimum allocation of the desired risk of failure of the system to all of its components. This paper studies the challenges in the design process of complex systems, the mathematical modeling of their topological architecture, and their unique behaviors. These characteristics make it impossible for the designer to use the common reliability and risk methodologies in the design process. The fundamental development of this work is an analytical upper bound for the distribution of risk of failure in the subsystem or element level. This upper bound satisfies the subadditivity condition of a coherent measure of risk. Additionally, its simplicity and low computational cost provide an appropriate framework as a fundamental building block for the risk-based design of complex systems. The proposed methodology is ap...
Alliance Principle 1.4: Visual Downangle Criteria for Navigation and Telematics Displays in Vehicles

The Alliance of Automotive Manufacturers (Alliance) has produced a document in which Principle 1.4 gives criteria and methods for calculating downvision angles to navigation and telematics displays in vehicles. This paper describes the details of the criteria and methods for determining compliance. Visual displays placed high in the vehicle instrument panel help drivers to use their peripheral vision to monitor the roadway for major developments, even during brief glances to the display. The Alliance has developed two criteria to define the maximum allowable downward viewing angle for displayed information in North American vehicles. One criterion is for use in two-dimensional Computer Aided Design (CAD) analyses, and one is for use in three-dimensional CAD analyses. Alliance Principle 1.4 is consistent with known driver performance research data, and known facts about the peripheral sensitivity of the human visual system.
Martin Buber's Myth of Zion: National Education or Counter-Education?.

If national education is, as Ilan Gur-Ze’ev thinks, inevitably a matter of agents for and victims of a national system, only a “counter-education” can correct it. Martin Buber shared many of Gur-Ze’ev’s concerns, but advocated a more positive view of national education. This essay examines Buber’s development of his pedagogical theory in its context, notes his influence on several educational models, investigates how his view of national education either continues or is ignored in the modern State of Israel, and shows that his positive view draws not only on his “I-Thou” dialogical insight but also on his advocacy of a myth of Zion, a myth that provides an alternative not just to the dominant myths in Israel today but also to Gur-Ze’ev’s counter-education.
Continuous Expression of I-A by Murine Peritoneal Macrophages IS Linked to the Bcg Gene

The expression of Major Histocompatibility Complex (MHC) class II glycoproteins is an important step in the immunological cascade. Antigen is processed and presented to antigen specific T lymphocytes by a small number of macrophages that are expressing la glycoproteins (Unanue, 1985) . The result of this interaction leads to the induction of Ia expression by other macrophages. These macrophages are induced to express Ia by the antigen responding T cells.
Applicability of Existing Reliability Models: Focus on Finite Element Modeling of Various BGA Package Designs and Materials

The work presented here is one of the key elements of an integrated methodology for predicting reliability in packaging systems (IMPRPK) developed by Arizona State University (ASU) and Intel. IMPRPK approach is based on a probabilistic methodology, focusing on three major tasks: (1) Finite Element analysis (FEM) to predict loading conditions, (2) Characterization of BGA solder joints to identify failure mechanisms and obtain statistical data, and (3) development of a probabilistic methodology to achieve an integrated reliability solution. The focus of this paper is on FEM (task 1), evaluating the effect of package design/form-factor and solder materials on the extent of deformation (e.g., inelastic stress/strain and strain energy density) experienced by BGA solder joints. Global and Local FEM results for two different package designs (Flip-chip and wire-bonded FLI) and two different BGA solder materials (lead-free SAC405 and lead-rich eutectic Sn37Pb) are discussed. The FEM results and the applicability o...
Standardized phantoms for quantitative cardiac MRI

Background Quantitative MR relaxometry techniques are increasingly used in cardiac MR applications, e.g. MOLLI for high resolution T1 mapping. To use these techniques in the clinic, we must understand how to make comparable measurements across vendor systems and software versions and compare results across sites. A standardized phantom used for regular quality control is one approach. The Biomagnetic Imaging program at the National Institute for Standards and Technology (NIST) has created phantoms for measuring T1, T2, proton density in collaboration with ISMRM (Fig. 1) and diffusion in collaboration with RSNA-QIBA. In addition, a breast phantom including T1 and diffusion components is in development with UCSF. We propose a cardiac phantom focused on quantitative measurements of the myocardium preand post-contrast and the blood pool. To test quantitative cardiac MR sequences, the phantom must mimic both the T1 and T2 relaxation properties in the same sample. The phantom must be stable, preferably for five years, and be reliably produced. Agarose gel is difficult to produce free of air bubbles and has a limited shelf life.
Comparison of Computer Simulations with Measurements From a-Si:H Imaging Arrays.

The design and characterization of flat panel a-Si:H arrays for imaging applications in radiotherapy and diagnostic radiology has already begun. Future improvements in design and performance will be heavily reliant on the results of computer simulations capable of accurately predicting the behavior of the arrays in a variety of operating conditions. These results will allow the design of new arrays to be optimized for the particular application before they are committed to fabrication. This paper outlines the results of an investigation into the effects of varying a number of array parameters and operating conditions using a simulation code which models the operation of a-Si:H devices. The results are compared with actual measurements from arrays fabricated at Xerox PARC.
Reaction of the subcutaneous tissue of rats to injected air.

SummarySingle discrete gas pockets were formed by injection of air into the dorsal subcutaneous tissue of rats. The presence of the gas caused a local morphological reorganization which was complete in 2 weeks. A wall, consisting mainly of modified fibroblasts and collagen fibers, developed around the gas and local vasculature increased in proportion to the wall thickness. After removal of the gas, opposing surfaces of the wall fused together and the collagen fibers with their associated cells were resorbed. Enlarged blood vessels remained after the other modified structures were no longer present in the pocket wall.
Metal-mediated hydrolysis of biological phosphate esters

Metal-mediated hydrolysis of phosphate esters is a common catalytic pathway in nucleic acid biochemistry. Two distinct models are principally invoked in mechanistic discussions of these reactions for magnesium-dependent nuclease activation, namely, the one- versus two-metal-ion pathways. By careful consideration of the available experimental data on a variety of enzymes (including the Klenow fragment of DNA pol I, exonuclease III, ribonuclease H domains of HIV reverse transcriptase and the homologous Escherichia coli enzyme, avian sarcoma virus integrase, Eco RI and Eco RV restriction endonucleases, and ribozymes), it is demonstrated that the two-metal-ion paradigm cannot be substantiated as a bona fide mechanism on the basis of the published structural data. The origins of the problems with this model are traced to fundamental issues in solution chemistry. These factors help to explain and resolve the often dichotomous results obtained from X-ray crystallography versus solution studies.
Emergence and Movement of the Saltmarsh Deer Flies Chrysops fuliginosus and Chrysops atlanticus

A study in 1970 of the saltmarsh deer flies on the Brigantine National Wildlife Refuge in New Jersey showed that Chrysops fuliginosus Wiedemann emerged May 23–June 25 and C. atlanticus Pechuman emerged June 10–August 3. C. fuliginosus emerged within 9.1 m of the ecotone, and where a fresh-water influence was observed. Collections on sticky panels showed both species tend to move upland. C. atlanticus persisted upland ca. 2 weeks after disappearing on the marsh, and it was most numerous ca. 180 m inland from the ecotone. C. fuliginosus showed less definite trends but was most dense ca. 90 m of the ecotone.
Development and application of automatic leveling device for grader

This paper discusses the working principle of the automatic leveling equipment, the application function in each period is analyzed and compared, and the direction of its future development is pointed out. Thus, it provides us with a theoretic basis on the design and optimization of the system.
Emergency Transfusions of Uncrossmatched Blood: Laboratory Features

The release of uncrossmatched units of O–RBCs at Veterans Affairs Medical Center (VAMC)–Memphis during the years 2012 and 2013 was reviewed. Laboratory features of all patients issued uncrossmatched units during these years were reviewed using the electronic medical record (EMR). There were 51 units of uncrossmatched RBCs issued to 36 patients during these 2 years. Patient types were O+ …
Mammography in West Virginia

A questionnaire was sent in 1988 to all sites conducting mammographic studies registered with the radiologic licensing division of the West Virginia State Department of Health Laboratory Services to determine the number of women served and the costs of the procedures. The number of sites, 61, appears excessive in view of the small number of women many of them screened during the course of a year and the high charges. Copies of the report on the questionnaire results were sent to agencies and other groups within the state to urge initiation of a more cost-effective system; however, four years later the number of units had increased substantially, and no coherent plan had been formulated. The report was helpful to members of the state legislature in their decision to mandate insurance coverage for women according to the American Cancer Society guidelines.
Ozone inactivates cyclooxygenase in human tracheal epithelial cells without altering PGHS-2 mRNA or protein

Exposure of human tracheal epithelial (TE) cells to ozone (0.1-0.5 ppm) leads to a transient increase followed by decreased production of prostaglandin (PG) E2 concomitant with dose-dependent loss and delayed recovery of cyclooxygenase (CO) activity [S.E. Alpert and R.W. Walenga. Am. J. Physiol. 269 (Lung Cell. Mol. Physiol. 13): L734-L743, 1995]. Formation of reactive oxygen species (ROS) in cultured tracheobronchial epithelial cells during ozone exposure was recently demonstrated (L.C. Chen and Q.Qu. Toxicol. Appl. Pharmacol. 143: 96-101, 1997). In the present study, we investigated if ROS generated by ozone-exposed human TE cells contribute to PGE2 production and/or CO inactivation and whether the delay in recovery of CO activity after ozone reflects impaired gene transcription and/or protein synthesis. Rapid, dose-dependent ROS generation, assessed by fluorescence of dihydrorhodamine 123, was detected in human TE monolayers exposed to 0.21-0.63 ppm ozone. In a different system, TE cells were exposed to air or 0.5 ppm ozone for 1 h by serial renewal/collection of an adherent film of media. Ozone-induced ROS formation, the transient increase and decline in PGE2, and CO inactivation were attenuated by an intracellular hydroxyl radical scavenger, 1,3-dimethyl-2-thiourea. Ibuprofen, a reversible CO inhibitor, prevented PGE2 release during ozone exposure (and hence autocatalytic CO inactivation) but not loss of CO activity. Although CO activity remained depressed for hours after ozone exposure, compared with air-exposed cultures, no differences were detected in mRNA and protein levels of prostaglandin endoperoxide G/H synthase 2 (PGHS-2), the only CO isoform present in human TE cells, or in the rate of de novo PGHS-2 synthesis. Our findings suggest that ozone-induced PGE2 production and CO inactivation are primarily the result of formation of intracellular oxidant molecules and that delayed recovery of CO activity in human TE cells after short-term ozone exposure is due to persistent inactivation of PGHS-2, rather than to interference with its synthesis.
Nerds, or neuroevolutionary rostral developers: a contribution to the future of characterology.

Abstract Psychoanalytic medicine can incorporate information from the neurosciences to expand anatomic characterology through new knowledge of brain function. One focus of interest that is not currently targeted by research into specific pathological conditions is that of the highly intelligent, scientific person. This paper designates by the ambivalent popular term “nerds” persons whose brain development enables them to manipulate very abstract concepts such as those in math and physics. This ability, which may be in the direction of human brain evolution, contributes to personality development in a way that is not conflicted but leads to investments of mental abilities with intense interest. Personality traits may result that are misunderstood and unpopular despite the crucial need for such persons at this point in our society's history. Portrayals of the nerd type in films, neurological, mental, and social factors favoring the development of nerds, and biographical and case materials round out this des...
The Overactive Bladder and the AUA Guidelines: A Proposed Clinical Pathway for Evaluation and Effective Management in a Contemporary Urology Practice

AbstractIntroduction: The 2014 American Urological Association Overactive Bladder Guidelines provide for the evaluation and effective treatment of patients with overactive bladder by all providers. Once the evaluation rules out other causes of these symptoms, the primary treatment of overactive bladder is behavioral. Changing bladder behavior is associated with a high degree of symptom improvement and is successful in most whereas cure remains elusive. Patient treatment outcomes will likely be inadequate if the patient remains uninformed about achievable bladder behavior, if shared and realistic goals of treatment are not established, and if the patient does not actively participate in modifying his/her bladder behavior.Methods: The senior authors of the AUA Overactive Bladder Guidelines from 2 major medical centers, specializing in lower urinary tract symptoms, present a unified clinical strategy for the busy outpatient clinic. A single visit rapidly evaluates and stratifies the management options for th...
Schwa at the phonology/syntax interface

It is claimed in this paper that the well known incongruence between the phonology and the syntax is resolved by removing syntactic boundaries by means of the rhythmic patterning. Resulting from this is a direct interface between the phonological phrasing and the syntax. The intermediary of the prosodic component is thereby eliminated. Accordingly, it is emphasized that language is rhythmic and that the rhythm of any given language directly interprets the syntactic constituency. The instrument by which this is achieved is the rhythmic foot, which contravenes the syntactic constituency directly and restructures it to align it with the rhythmic patterning. In contrast to Nespor (1990), therefore, this approach takes into account no separation between the prosody and rhythm. As a result, it limits the need for pre-compiled rules as proposed by Hayes (1990). Especially targeted in relation to this discussion is the behavior of French schwa.
THE MARCH: Stand With Us and Say “No More”

Hype or hope? We have heard these words characterize recent reports on this country's so-called "war against cancer." For the eight million people like me who have had cancer, and for the millions that are being diagnosed this year, nothing happens soon enough. But, I am concerned about the message this type of reporting sends to people and the phones that then ring off the hook at my office from people who are desperately looking for a "cure for cancer." How are we going to translate this science into applications for people? How are people going to get access to it? We don't have a healthcare system that wants to pay for clinical research, which is what we're talking about here. This is a serious problem. And this problem is not new to us. My name is Ellen Stovall and I am one of this country's more than eight million cancer survivors. On December 23, 1971, President Richard Nixon signed into law the National Cancer Act. That day also marked something very personal for me. That was the day I began treatment for Hodgkin's disease. I remember going home that night rocking to sleep my two-month-old baby boy, Jonathan. He's now 26. And I remember my dear father calling me to tell me that he had seen the President on television that night, and that the President had declared a war on cancer for me. Today, that seven-year promise goes unfulfilled. Nearly 27 years later, we are still waiting. We have grown tired of waiting. We have been silent too long. We must begin to say, "NO MORE." On September 26, 1998, cancer survivors, their families, friends, caregivers, and co-workers-everyone whose life has been touched by cancer-will rally on The Mall in Washington, D.C. and in communities across the country as part of a national grassroots campaign to make cancer our nation's #1 research and healthcare priority. I invite you to join us in this campaign, called THE MARCH.Coming Together To Conquer Cancertrade mark.
Lumped Mass Modelling and Chaotic Behavior of an Elastic Levitated Droplet

In this paper, a nonlinear dynamicsanalysis of simulated data was considered to study the timeevolution of an electromagnetically levitated (ELM) flexibledroplet. The flexible droplet is modelled as a system with lumpedmasses, elastic springs, and rigid links. The behavior of thelevitated droplet was investigated. Quantities characterizing timeseries data such as attractor dimension or largest Lyapunovexponent were computed. Calculations were performed for dropletsof aluminum and copper. Thus, its chaotic behavior was analyzed.
Neuronal protection against oxidative insult by polyanhydride nanoparticle-based mitochondria-targeted antioxidant therapy

A progressive loss of neuronal structure and function is a signature of many neurodegenerative conditions including chronic traumatic encephalopathy, Parkinson's, Huntington's and Alzheimer's diseases. Mitochondrial dysfunction and oxidative and nitrative stress have been implicated as key pathological mechanisms underlying the neurodegenerative processes. However, current therapeutic approaches targeting oxidative damage are ineffective in preventing the progression of neurodegeneration. Mitochondria-targeted antioxidants were recently shown to alleviate oxidative damage. In this work, we investigated the delivery of biodegradable polyanhydride nanoparticles containing the mitochondria-targeted antioxidant apocynin to neuronal cells and the ability of the nano-formulation to protect cells against oxidative stress. The nano-formulated mitochondria-targeted apocynin provided excellent protection against oxidative stress-induced mitochondrial dysfunction and neuronal damage in a dopaminergic neuronal cell line, mouse primary cortical neurons, and a human mesencephalic cell line. Collectively, our results demonstrate that nano-formulated mitochondria-targeted apocynin may offer improved efficacy of mitochondria-targeted antioxidants to treat neurodegenerative disease.
Air–Sea/Land Interaction in the Coastal Zone

Atmospheric turbulence measurements made at the U.S. Army Corps of Engineers Field Research Facility (FRF) located on the Atlantic coast near the town of Duck, North Carolina during the CASPER-East Program (October–November 2015) are used to study air–sea/land coupling in the FRF coastal zone. Turbulence and mean meteorological data were collected at multiple levels (up to four) on three towers deployed at different landward distances from the shoreline, with a fourth tower located at the end of a 560-m-long FRF pier. The data enable comparison of turbulent fluxes and other statistics, as well as investigations of surface-layer scaling for different footprints, including relatively smooth sea-surface conditions and aerodynamically rough dry inland areas. Both stable and unstable stratifications were observed. The drag coefficient and diurnal variation of the sensible heat flux are found to be indicators for disparate surface footprints. The drag coefficient over the land footprint is significantly greater, by as much as an order of magnitude, compared with that over the smooth sea-surface footprint. For onshore flow, the internal boundary layer in the coastal zone was either stable or (mostly) unstable, and varied dramatically at the land-surface discontinuity. The offshore flow of generally warm air over the cooler sea surface produced a stable internal boundary layer over the ocean surface downstream from the coast. While the coastal inhomogeneities violate the assumptions underlying Monin–Obukhov similarity theory (MOST), any deviations from MOST are less profound for the scaled standard deviations and the dissipation rate over both water and land, as well as for stable and unstable conditions. Observations, however, show a poor correspondence with MOST for the flux-profile relationships. Suitably-averaged, non-dimensional profiles of wind speed and temperature vary significantly among the different flux towers and observation levels, with high data scatter. Overall, the statistical dependence of the vertical gradients of scaled wind speed and temperature on the Monin–Obukhov stability parameter in the coastal area is weak, if not non-existent.
A single dose polyanhydride-based vaccine platform promotes and maintains anti-GnRH antibody titers

Abstract Traditionally, vaccination strategies require an initial priming vaccination followed by an antigen boost to generate adequate immunity. Here we describe vaccination against a self-peptide for reproductive sterilization utilizing a three-stage vaccine platform consisting of gonadotropin releasing hormone multiple antigenic peptide (GnRH-MAP) as a soluble injection coupled with subcutaneous administration of polyanhydride-immobilized GnRH-MAP and a cyto-exclusive implant containing GnRH-MAP dendrimer-loaded polyanhydride. This strategy generated and maintained cell-mediated and humoral immunity for up to 41 weeks after a single vaccination in mice with enhanced antibody avidity over time. All intact implants had a grossly visible tissue interface with neovascularization and lymphocytic aggregates. Despite detectable immunity, sterility was not achieved and the immune response did not lead to azoospermia in male mice nor prevent estrus and ovulation in female mice. However, the vaccine delivery device is tunable and the immunogen, adjuvants and release rates can all be modified to enhance immunity. This technology has broad implications for the development of long-term vaccination schemes.
The Consequences of Inappropriate Use of Emergency Imaging

Inappropriate use of diagnostic imaging in the emergency department setting is a growing concern. Multiple factors drive imaging utilization in the ED, and diagnostic imaging use has increased dramatically in the past two decades. Medical radiation now accounts for the largest percent of artificial exposure to ionizing radiation in the USA, and while a direct link between radiation exposure from imaging and cancer development has not been proven, there is increasing concern about the potential health effects of repeated exposure to medical radiation, especially in the pediatric population. Incidental findings are common and can be difficult to communicate and manage. Several methods have been proposed to reduce inappropriate imaging utilization, and clinical decision support integration with computerized order entry was recently mandated by the US Department of Health and Human Services. Further study into the impact of clinical decision support systems and radiologist-driven educational interventions is warranted, and development of guidelines for management of incidental findings is encouraged.
An Agent-Based Model of Healthy Eating with Applications to Hypertension

Changing descriptive social norm in health behavior (“how many people are behaving healthy”) has been shown to be effective in promoting healthy eating. We developed an agent-based model to explore the potential of changing social norm in reducing hypertension among the adult population of Los Angeles County. The model uses the 2007 California Health Interview Survey (CHIS) to create a virtual population that mimics the joint distribution of demographic characteristics and health behavior in the Los Angeles County. We calibrated the outcome of hypertension as a function of individual age and fruits/vegetable consumption, based upon the observed pattern in the survey. We then simulated an intervention scenario to promote healthier eating by increasing the visibility (i.e. descriptive social norms) of those who eat at least one serving of fruits/vegetable per day. We compare the hypertension incidence under the status quo scenario and the intervention scenario. We found that the effect size of 5% in social norm enhancement yields a reduction in 5 year hypertension incidence by 10.08%. An effect size of 15% would reduce incidence by 15.50%. In conclusion, the agent-based model built and calibrated around real-world data shows that changes descriptive social norms in healthy eating can be effective to reduce the burden of hypertension. The model can be improved in the future by also including the chronic conditions that are affected by changes in fruits/vegetable consumption.
Aperture Filter Functions

In the last chapter expressions for phase and log-amplitude variances were derived. These expressions contained an aperture filter function. In this chapter explicit filter functions are derived for many cases of interest. First, those needed to calculate variances of any Zernike mode on an unobscured circular aperture are found. Next, expressions to find piston and tilt on an annular aperture are derived.
Colostrum as a Therapeutic for Premature Infants

Extremely low birth weight (ELBW: birthweight <1,000 g) infants represent the smallest and sickest of the premature population. Despite dramatic advances in neonatal medicine and technology which have significantly decreased mortality, survivors are burdened with significant morbidity associated with prematurity-related diseases [1–3]. Of particular concern are nosocomial infections such as bacteremia, ventilator-associated pneumonia (VAP), and a potentially lethal gastrointestinal infectious and inflammatory disorder known as necrotizing enterocolitis (NEC). These morbidities are highly prevalent, costly, increase the length of hospitalization, and are associated with a potential for adverse neurodevelopmental outcomes in survivors [4–6].
Potential Pharmacological Use of Neurotrophic Factors in the Treatment of Neurodegenerative Diseases

There is growing evidence that development, maintenance of function, and regeneration of neurons are influenced by trophic hormones or neurotrophic factors. These neurotrophic factors stimulate mechanisms necessary for survival, neurite growth and functions related to transmitter production and release. Nerve growth factor (NGF) is the first and best characterized neurotrophic factor and serves as a paradigm for more recently discovered molecules. NGF trophically acts on peripheral sympathetic and sensory neurons, and cholinergic neurons in the brain. Other neurotrophic molecules characterized so far influence various other neuronal populations. Brain-derived neurotrophic factor is a protein purified from pig brain which supports the survival of chick sensory neurons and rat retinal ganglion cells. Glia- derived nexin produced by glial cells and inducing neurite growth of neuroblastoma cells was found to br an inhibitor of cell- derived protteases. Thid finding is in line with other evdence for a role of proteases an d protease inhibitors in neurite growth and regeneration.
Pneumonia-Associated Hospitalizations, New York City, 2001-2014.

Objectives:Death certificate data indicate that the age-adjusted death rate for pneumonia and influenza is higher in New York City than in the United States. Most pneumonia and influenza deaths are...
Dreamwork for Dramatic Writing: An Organic Approach to Magic and Theatricality

In this chapter, David Crespy shares his dreamwork for dramatic writing workshop that he has taught through such venues as the Association for Theatre in Higher Education, the Mid-America Theatre Conference, the International Association for the Study of Dreams, Hollins University PlayLab, and the Kennedy Center American College Theatre Festival. The work here focuses on dramatic writing, but the notion of the dream cache is useful to any storyteller looking for a creative method to innovate their story technique. Using the lens of phenomenology, and techniques suggested by performance theorist Bert O. States, Crespy attempts to “unmask” the way dreams and fiction interact for the playwright or screenwriter. Dreams offer an unlimited supply of ideas, form, technique, and structure for writers who are trying to surprise themselves out of cliches received from the echo chamber of Broadway and Hollywood. This form of dreamwork is about transforming as a storyteller and changing one’s ideas about what makes an adventurous tale.
Impact of Aspirin and Other NSAID Use on Volumetric and Linear Growth in Vestibular Schwannoma.

ObjectivesConflicting research exists surrounding the utility of aspirin to prevent tumor growth in the medical management of vestibular schwannoma (VS). Recent studies demonstrated no association ...
Galatians 6:1–10: Caring for Other Employees—To a Point

Galatians 6 presents guidelines of the value of employees helping each other but only to the point of not causing their failure as a result of helping too much. Galatians 6 includes the admonition to not brag about helping others but to focus on doing your work without the need for help. This teaching was in contrast to the then-present cultural concept of shame and honor. Galatians 6 implies that employees should not seek honor for self or infer shame on others.
Experiments for the Detection of Solitons in Biopolymers

Unfortunately it is not possible to sneak inside a biological system with a camera and snap a picture of an object labeled “soliton”. And yet that is not unlike what we are trying to do when we ask solitons in biological systems to reveal themselves to experimental scrutiny. The sign must say “soliton” and not “exciton” or “conformational change” or any other plausible identification, because the theory of nonlinear interactions is relatively new to biophysics and it has not yet been firmly established experimentally. Moreover, such confirmation is not likely to come from any single definitive experiment. Rather, we expect to build up a large body of evidence, from a variety of experiments that approach the problem from different angles, which when taken all together would constitute a convincing case.
Population Sizes, Rhinocyllus conicus Use, and Patterns of Genetic Variation of Cirsium ownbeyi, a Rare Native Thistle, in Wyoming

Cirsium ownbeyi is a habitat-specific, endemic, polycarpic thistle in northwest Colorado, northeast Utah, and southwest Wyoming. In 1998, seven C. ownbeyi populations, which ranged from 4 to >30,000 plants, were known from Wyoming. The population genetics of C. ownbeyi and the threat posed by an exotic flower head–feeding weevil, Rhinocyllus conicus, in Wyoming are unknown. Between 2014 and 2016, we visited Wyoming C. ownbeyi populations to determine (1) changes in population sizes since 1998, (2) extent of R. conicus use, and (3) amount and distribution of genetic variation within and between populations. We quantified densities of plants within populations by life stage, population spatial extents, and, for 10 plants per population, proportion of flower heads with R. conicus ovipositions. Data at 6 simple sequence repeat loci were also collected. Three C. ownbeyi populations were <10% of their 1998 estimated size, 3 populations were unchanged, and one population was substantially larger than in 1998. We found Rhinocyllus conicus oviposition in all Wyoming C. ownbeyi populations, and we interpret increasing use by this weevil over our monitoring period as indicating recent colonization. Low FST and FIS values suggest that levels of C. ownbeyi inbreeding were low and that there was considerable gene flow among populations. Genetic variation increased with popu lation size, although a small C. ownbeyi population was the most divergent. We conclude that C. ownbeyi was less abundant in Wyoming in 2015–2016 than was estimated in 1998. Causes of changes in population sizes are unknown and likely vary among populations. The positive relationship between population size and genetic diversity notwithstanding, protecting small populations can preserve unique local gene pools in this rare species.
Abstract 16165: Cardiac Overexpression of Membrane Type-1 Matrix Metalloproteinase Causes Left Ventricular Remodeling and Pump Dysfunction in Peripartum Cardiomyopathy

Introduction: Peripartum cardiomyopathy (PPCM) is a rare cause of heart failure (HF) in pregnancy. Like other forms of HF, left ventricular (LV) remodeling (LV dilation and LV pump dysfunction) occur with PPCM. The matrix metalloproteinases (MMPs) are implicated as a cause of adverse left ventricular (LV) remodeling and progression to HF. However, the role of MMPs in PPCM remains unclear. Within the class of membrane type MMPs, the subtype membrane type-1 MMP (MT1-MMP) is expressed in human myocardium and is known to be increased in HF. We tested the hypothesis that a causal relationship exists between myocardial overexpression of MT1-MMP and the development of PPCM. Methods/Results: Pregnant transgenic mice designed to overexpress MT1-MMP (MT1OE; n=8) in cardiomyocytes and littermate wild-type (WT; n=8) and corresponding non-pregnant controls (n=6 each group) were used. MT1-MMP activity was higher in the non-pregnant MT1OE mice than in WT mice and further differentially increased with pregnancy (Fig, pan...
Rheological properties of ultra-high-performance concrete — An overview

Abstract Ultra-high-performance concrete (UHPC) is attracting increasing interests worldwide due to its superior mechanical properties and durability. Securing proper rheological properties can affect fiber dispersion and alignment with marked effect on UHPC performance. Tailoring the rheological properties of UHPC to secure enhanced performance is not widely considered in the mixture design stage. In this paper, an overview of the rheological properties of UHPC, applicable flow models, measurement techniques and errors associated with the interpretation of rheological measurements are discussed. The effect of various constituent materials on rheological properties of UHPC is presented. This includes the cementitious materials, sand, chemical admixtures, fibers, nanomaterials, and internal curing agents. Most importantly, the paper discusses the rheological properties requirements of UHPC and strategies to control rheology of UHPC targeted for different applications, such as repair and rehabilitation, bridge deck panel connections, construction of structural and architectural elements, and digital fabrication.
Between Secrecy and Transparency: Conversions to Protestantism Among Iranian Refugees in Germany

Present-day scholarship on religious conversions diverts from classic Protestant paradigms of sudden conversions and instant transformations of the self. Instead, it stresses that converts make active choices that are influenced by specific contexts and historical changes. This becomes evident in an ethnographic study of one controversial aspect of the recent refugee influx in Germany: the so-called mass conversions of Iranian refugees from Shia Islam to Christianity, which have been highly publicized and criticized since the height of immigration in 2015. The analysis draws on interview data with Iranian refugee converts and their pastors in Protestant churches in North Rhine-Westphalia between October 2017 and January 2018. The study reveals the need to theorize the symbiotic connection between religious contacts, forced migration, and conversion to Christianity. It applies Rambo’s (1993) stage model of conversion and the analytical concept of secrecy (Jones 2014, Manderson et al. 2015, Simmel 1906) to demonstrate that the Iranian refugees’ conversions are shaped by contexts, crises, encounters, quests, interactions, commitments, and consequences (Rambo 1993) as they negotiate the forces of secrecy, risk, transparency, and the benefits of being a Christian. The goal of this paper is to find thematic patterns in their narratives that can be systematized and can build a foundation for further study.
Evaluation of a Training Program to Improve Organizational Capacity for Health Systems Analytics.

Objective The Leadership in Analytics and Data Science (LEADS) course was evaluated for effectiveness. LEADS was a 6-month program for working biomedical and health informatics (BMHI) professionals designed to improve analytics skills, knowledge of enterprise applications, data stewardship, and to foster an analytics community of practice through lectures, hands-on skill building workshops, networking events, and small group projects. Methods The effectiveness of the LEADS course was evaluated using the Kirkpatrick Model by assessing pre- and postcourse knowledge, analytics capabilities, goals, practice, class lecture reaction, and change in the size of participant professional networks. Differences in pre- and postcourse responses were analyzed with a Wilcoxon signed rank test to determine significance, and effect sizes were computed using a z-statistic. Results Twenty-nine students completed the course with 96% of respondents reporting that they were “very” or “extremely” likely to recommend the course. Participants reported improvement in several analytics capabilities including Epic data warehousing (p = 0.017), institutional review board policy (p = 0.005), and data stewardship (p = 0.007). Changes in practice patterns mirrored those in self-reported capability. On average, the participant professional network doubled. Conclusion LEADS was the first course targeted to working BMHI professional at a large academic medical center to have a formal effectiveness evaluation be published in the literature. The course achieved the goals of expansion of BMHI knowledge, skills, and professional networks. The LEADS course provides a template for continuing education of working BMHI professionals.
Cervical Spondylotic Amyotrophy: Case Series and Review of the Literature.

Objective Cervical spondylotic amyotrophy (CSA) is a relatively rare entity caused by cervical degenerative spinal diseases and characterized by motor weakness accompanied by remarkable muscle atrophy in the upper extremities without significant sensory deficits or spastic paraparesis in the lower extremities. Postoperative outcomes and predictive prognostic factors vary among previous reports. In the present report, we describe the surgical results in patients who were surgically treated for CSA and present a literature review.
Data from a terminated study on iron oxide nanoparticle magnetic resonance imaging for head and neck tumors

Node positive head and neck squamous cell carcinomas (HNSCCs) patients exhibit worse outcomes in terms of regional neck control, risk for distant metastases and overall survival. Smaller non-palpable lymph nodes may be inflammatory or may harbor clinically occult metastases, a characterization that can be challenging to make using routine imaging modalities. Ferumoxytol has been previously investigated as an intra-tumoral contrast agent for magnetic resonance imaging (MRI) for intracranial malignancies and lymph node agent in prostate cancer. Hence, our group was motivated to carry out a prospective feasibility study to assess the feasibility of ferumoxytol dynamic contrast enhanced (DCE)-weighted MRI relative to that of gadolinium-based DCE-MRI for nodal and primary tumor imaging in patients with biopsy-proven node-positive HNSCC or melanoma. Although this institutional review board (IRB)-approved study was prematurely terminated because of an FDA black box warning, the investigators sought to curate and publish this unique dataset of matched clinical, and anatomical and DCE MRI data for the enrolled five patients to be available for scientists interested in molecular imaging. Machine-accessible metadata file describing the reported data: https://doi.org/10.6084/m9.figshare.11409516
Youth Has No Age: Cancer Treatment for Older Americans

Calendar age and biological age do not always correspond. Pablo Picasso, source of the quote that begins the title of this commentary, lived a notoriously robust and active life through his later decades, dying in his nineties in the midst of a dinner party. In the oncology community, with the advent of targeted therapeutics and better supportive care, the disparity between the two is likely to be increasingly relevant to both research and practice. In this issue of ONCOLOGY, Chiappori et al review data supporting the idea that even in the context of standard cytotoxic chemotherapy, elderly patients with advanced NSCLC experience similar response rates and similar survival benefits to those seen in younger patients. They note that biases excluding elderly patients from clinical trials result in gaps in our knowledge of how to best treat older patients.
Prevalence and significance of clonal hematopoiesis of indeterminate prognosis (CHIP) in multiple myeloma.

8542Background: Clonal hematopoiesis of indeterminate potential (CHIP) is defined by the presence of leukemia-associated somatic mutations in clonally expanded hematopoietic stem cells with a VAF o...
Observing Topological Invariants Using Quantum Walks in Superconducting Circuits

Topological invariants, properties of a system that remain unchanged by small deformations, are key to modern understanding of phases of matter but have yet to be directly detected by experiment. A new quantum simulation shows how quantum walks can be used to measure topological invariants for the first time.
COVID-19 and beyond: Telesupervision training within the supervision competency

The COVID-19 pandemic produced a rapid and pervasive shift to provision of telepsychology services throughout health service psychology Simultaneously, an equally rapid and pervasive shift to telesupervision of trainees has occurred, at all levels of graduate professional training These shifts have clearly outpaced a much more gradual increase in training in telesupervision as part of the supervision competency The authors provide an overview of the somewhat limited research on telesupervision, and propose rapid adoption of training in telesupervision for both trainees and supervisors Several areas of research into telesupervision are proposed, including comparative efficacy and acceptance of telesupervision, the potential impact of information technology expertise on supervisory relationships, and potential differential impact of diversity factors in telesupervision as compared to in-person supervision (PsycInfo Database Record (c) 2021 APA, all rights reserved) Impact Statement Public Significance Statement-The COVID-19 pandemic resulted in increased use of telesupervision in health service psychology training, despite limited research and training specific to telesupervision Continued research and incorporation of education and practice of telesupervision to develop trainees' supervision competency could help alleviate the gap between practice and training in telesupervision beyond the pandemic (PsycInfo Database Record (c) 2021 APA, all rights reserved)
Androgen Deprivation Therapy for Patients with Intact Prostates Undergoing Radiation Therapy

Androgen deprivation therapy (ADT) has the goal of lowering androgens to mitigate growth of prostate cancer. Parameters to consider in determining whether to add ADT to radiation and the duration of hormone therapy include prostate cancer risk group, prior therapy, comorbidities, and the adverse effects of ADT. In this chapter, we discuss ADT for patients with intact prostates undergoing radiotherapy. We consider the use of ADT with external beam radiation therapy (EBRT) for select healthy patients with favorable intermediate-risk prostate cancer. We generally use 4–6 months of ADT with EBRT for most patients with unfavorable intermediate-risk prostate cancer. We generally use 2 years ADT with EBRT for high-risk and locally advanced prostate cancer, although ADT may be stopped at 18 months if the patient tolerates ADT poorly. Genomics-based risk scores may help decision-making, although the predictive value of genomic risk scores is still being tested prospectively. Adverse effects of ADT include hot flashes, gynecomastia, metabolic changes such as weight gain and increased fat mass, and increased risk of fractures. Some data also suggest increased risk of cardiovascular adverse effects with ADT.
16 Second Optical Quasi-Periodic Oscillations in GX 339–4

We report the results of high-speed optical white-light photometry of the black hole candidate GX 339-4, obtained at the Cerro Tololo Inter-American Observatory during 1996 April. We searched the data for strictly periodic features, quasi-periodic oscillations (QPOs), and aperiodic variability (noise) using Fourier and wavelet techniques. (1) We found a QPO with amplitude 4.5%-6%, frequency f ~ 0.064 Hz, and width Δf/f ~ 0.3-0.5. The QPO was long-lived in that it was present in all segments of the data, even in sets acquired one day apart. (2) In addition to the 0.064 Hz QPO there are indications of low-amplitude QPOs at f = 0.02, 0.03, 0.08, 0.3, and 3 Hz. None of the features appeared in more than one day of data (except for the 0.08 Hz feature) and none of the features were as strong as the 0.064 Hz QPO, and so they should be taken with some caution. (3) We found power in excess of counting statistics out to frequencies of several hertz on both nights. The origin of this excess power is not clear.