cssi/SciSciGPT-SciSciNet huggingface dataset:
Comparison of different methods for predicting customized drug dosage in superovulation stage of in-vitro fertilization

In vitro fertilization (IVF) is one of the highly pursued assisted reproductive technologies (ART) worldwide. The IVF procedure is divided into four stages: superovulation, egg-retrieval, insemination/fertilization and embryo transfer. Superovulation is the most crucial stage in IVF, since it involves injection of hormones externally to stimulate development and maturation of multiple oocytes. Although numerous advancements have been made in IVF procedures, little attention has been given to modifying the standard protocols based on a predictive model. In reality every patient responds differently and hence the proposition to modify the amounts of drug administered based on the patient’s initial treatment response is a reasonable approach. A model for the follicular dynamics as a function of injected hormones and patient characteristics has been developed and validated. Using the model and optimal control theory, the optimal dose and frequency of medication customized for each patient is predicted. The problem is solved by different methods like the maximum principle and discretized non-linear programming.
On a consequence of the order ideal conjecture

Abstract Given a minimal set of generators x of an ideal I of height d in a regular local ring ( R , m , k ) , we prove several cases for which the map K d ( x ; R ) ⊗ k → Tor d R ( R / I , k ) is the 0-map. As a consequence of the order ideal conjecture, we derive several cases for which K d + i ( x ; R ) ⊗ k → Tor d + i R ( R / I , k ) are 0-maps for i ≥ 0 .
Positive combinations of projections in von Neumann algebras and purely infinite simple C *-algebras

We give an overview of the question: which positive elements in an operator algebra can be written as a linear combination of projections with positive coefficients. A special case of independent interest is the question of which positive elements can be written as a sum of finitely many projections. We focus on von Neumann algebras, on purely infinite simple C*-algebras, and on their associated multiplier algebras.
No spurious local minima in nonconvex low rank problems: a unified geometric analysis

In this paper we develop a new framework that captures the common landscape underlying the common non-convex low-rank matrix problems including matrix sensing, matrix completion and robust PCA. In particular, we show for all above problems (including asymmetric cases): 1) all local minima are also globally optimal; 2) no high-order saddle points exists. These results explain why simple algorithms such as stochastic gradient descent have global converge, and efficiently optimize these non-convex objective functions in practice. Our framework connects and simplifies the existing analyses on optimization landscapes for matrix sensing and symmetric matrix completion. The framework naturally leads to new results for asymmetric matrix completion and robust PCA.
CEO-board dynamics

Abstract We examine CEO-board dynamics using a new panel dataset that spans 1920 to 2011. The long sample allows us to perform within-firm and within-CEO tests over a long horizon, many for the first time in the governance literature. Consistent with theories of bargaining or dynamic contracting, we find board independence increases at CEO turnover and falls with CEO tenure, with the decline stronger following superior performance. CEOs are also more likely to be appointed board chair as tenure increases, and we find evidence consistent with a substitution between board independence and chair duality. Other results suggest that these classes of models fail to capture important elements of board dynamics. First, the magnitude of the CEO tenure effect is economically small, much smaller, for example, than the strong persistence in board structure that we show. Second, when external CEOs are hired, board independence falls and subsequently increases. Third, event studies show a positive market reaction when powerful CEOs die in office, consistent with powerful CEOs becoming entrenched.
Slipped capital femoral epiphysis: a spectrum of surgical care and changes over time.

Abstract Purpose To survey the spectrum of surgical care in children with slipped capital femoral epiphysis (SCFE). This information is valuable in counselling the patient about the future treatment course. Methods Data for this study were obtained from the Pediatric Hospital Information System (PHIS) between 2004 and 2015. For all patients with an ICD9 diagnosis of 732.2, gender, ethnicity, hospital, medical record number, date of birth/admission/discharge, type of admission, length of stay, disposition and treatment(s) rendered were collected. Results A total of 13 168 procedures were performed in 11 058 unique SCFE patients, or 1.2 procedures per patient. Primary procedures were those performed for the initial treatment of the SCFE and secondary procedures as reconstructive and salvage. The majority (11 693, 88.8%) were primary. There was significant variation in the ratio of primary and secondary procedures by institution. There was a decline in in situ fixation as the initial SCFE treatment with an i...
Visual heuristics for marginal effects plots

Common visual heuristics used to interpret marginal effects plots are susceptible to Type-1 error. This susceptibility varies as a function of (a) sample size, (b) stochastic error in the true data...
Generating Language Activities in Real-Time for English Learners using Language Muse

K-12 education standards in the U.S. require all students to read complex texts across many subject areas. The Language Muse™ Activity Palette is a web-based language-instruction application that uses NLP algorithms and lexical resources to automatically generate language activities and support English language learners' content comprehension and language skills development. The system's online platform for activity generation, scoring, and feedback is scalable for MOOCs, as well as for other online learning settings.
The utility of single-item readiness screeners in middle school☆

Abstract This study examined the benefit of utilizing one-item academic and one-item behavior readiness teacher-rated screeners at the beginning of the school year to predict end-of-school year outcomes for middle school students. The Middle School Academic and Behavior Readiness (M-ABR) screeners were developed to provide an efficient and effective way to assess readiness in students. Participants included 889 students in 62 middle school classrooms in an urban Missouri school district. Concurrent validity with the M-ABR items and other indicators of readiness in the fall were evaluated using Pearson product-moment correlation coefficients, with the academic readiness item having medium to strong correlations with other baseline academic indicators (r = ± 0.56 to 0.91) and the behavior readiness item having low to strong correlations with baseline behavior items (r = ± 0.20 to 0.79). Next, the predictive validity of the M-ABR items was analyzed with hierarchical linear regressions using end-of-year outcomes as the dependent variable. The academic and behavior readiness items demonstrated adequate validity for all outcomes with moderate effects (β = ± 0.31 to 0.73 for academic outcomes and β = ± 0.24 to 0.59 for behavioral outcomes) after controlling for baseline demographics. Even after controlling for baseline scores, the M-ABR items predicted unique variance in almost all outcome variables. Four conditional probability indices were calculated to obtain an optimal cut score, to determine ready vs. not ready, for both single-item M-ABR scales. The cut point of “fair” yielded the most acceptable values for the indices. The odd ratios (OR) of experiencing negative outcomes given a “fair” or lower readiness rating (2 or below on the M-ABR screeners) at the beginning of the year were significant and strong for all outcomes (OR = 2.29 to OR = 14.46), except for internalizing problems. These findings suggest promise for using single readiness items to screen for varying negative end-of-year student outcomes.
Female Land Ownership and Fertility in Nepal

This paper examines the association between female land ownership and fertility in Nepal using propensity score methods. A female land owner is found to have an average of 0.26–0.47 fewer children than her non-owner counterpart. Such negative female land-fertility trends are observed for women in different age groups. Evidence indicates that female land ownership promotes women’s wealth and decision-making authority, which could be the pathways through which their fertility is influenced. These findings imply that female land ownership could have substantial welfare benefits for women and population implications for countries.
Who reads patents

Biotechnology and chemistry researchers look to the patent literature as a source of technical information more than researchers in other fields, and few researchers are deterred from reading patents by concerns about enhanced legal liability.
Saturated Fatty Acids and Cardiovascular Disease: Replacements for Saturated Fat to Reduce Cardiovascular Risk.

Dietary recommendations to decrease the risk of cardiovascular disease (CVD) have focused on reducing intake of saturated fatty acids (SFA) for more than 50 years. While the 2015–2020 Dietary Guidelines for Americans advise substituting both monounsaturated and polyunsaturated fatty acids for SFA, evidence supports other nutrient substitutions that will also reduce CVD risk. For example, replacing SFA with whole grains, but not refined carbohydrates, reduces CVD risk. Replacing SFA with protein, especially plant protein, may also reduce CVD risk. While dairy fat (milk, cheese) is associated with a slightly lower CVD risk compared to meat, dairy fat results in a significantly greater CVD risk relative to unsaturated fatty acids. As research continues, we will refine our understanding of dietary patterns associated with lower CVD risk.
About the $L^2$ analyticity of Markov operators on graphs

Let $\Gamma$ be a graph and $P$ be a reversible random walk on $\Gamma$. From the $L^2$ analyticity of the Markov operator $P$, we deduce that an iterate of odd exponent of $P$ is `lazy', that is there exists an integer $k$ such that the transition probability (for the random walk $P^{2k+1}$) from a vertex $x$ to itself is uniformly bounded from below. The proof does not require the doubling property on $\Gamma$ but only a polynomial control of the volume.
Aluminum-Containing Dense Deposits of the Glomerular Basement Membrane. Identification by Energy Dispersive X-Ray Analysis

Heavy metals, including gold, mercury, lead, bismuth, and cadmium, have the potential to cause renal disease. With the development of X-ray microanalysis, these heavy metals can now be identified in tissue deposits. This report describes a case of renal failure, probably related to dysproteinemia, in which granular, electron-opaque dense deposits were present in the glomerular basement membranes. Energy dispersive X-ray analysis demonstrated that these dense deposits contained aluminum. An analysis of this patient's history in relation to the current knowledge of aluminum metabolism suggests that the aluminum deposition occurred secondary to previous glomerular injury. This case emphasizes the need to utilize heavy metal identification technology whenever granular, electron-opaque dense deposits are identified and represents, to our knowledge, the first study to document aluminum deposits within the glomerular basement membrane of humans.
Radionuclide Scanning in Children With Rhabdomyosarcoma

Radionuclide scintigraphy was performed in 46 children with rhabdomyosarcoma. Of the 63 radiologically confirmed sites of bone disease, 76% were detected by 99mTc-labeled phosphate uptake. All 15 sites of hepatic involvement and eight of the nine cranial sites of disease exhibited isotope accumulation. Gallium 67 scans showed 57% of the 43 proven sites of disease, including four previously unsuspected areas. Twelve false-positive sites were obtained with gallium. Radionuclide scanning is a valuable aid in the diagnostic evaluation and management of childhood rhabdomyosarcoma.
Varied Types of Urinary Calculi in a Patient With Cystinosis Without Renal Tubular Acidosis

Renal calculi have rarely been cited as a major manifestation of cystinosis. We report a case history of a child with multiple urate calculi and a calcium oxalate stone resulting from proximal tubular dysfunction that was not associated with bicarbonate wastage.
Interruption of the Inferior Vena Cava by Clip or Filter

Interruption of the inferior vena cava is usually performed with either external clipping or transvenous filter placement. For patients unable to tolerate general anesthesia and laparotomy, the advantages of transvenous filters rather than clips are obvious. However, for some patients, the use of either clips or filters is possible. In general, retrospective observational studies of inferior vena caval interruption have not adequately accounted for baseline patient characteristics such as age, presence of cancer, and history of prior venous thromboembolism. These confounding factors can independently affect subsequent rates of both recurrent embolism and overall mortality. A comparative, controlled, prospective evaluation of inferior vena caval clipping versus transvenous filter placement among patients who are appropriate candidates for either procedure has not been undertaken. It is suggested that, among patients with good long-term prognoses, a randomized controlled trial would be necessary to help determine whether clipping or transvenous filter placement is more efficacious.
Pelvic Lymphadenectomy and Radical Cystectomy for Transitional Cell Carcinoma of the Bladder With Pelvic Nodal Disease

Abstract Past and present methods of treatment for patients with stage D1 (T1-4 N+ MO) transitional cell cancer of the urinary bladder have proved to be largely ineffective. This report on 57 patients with stage D1 disease confirms this impression and demonstrates that radical operation alone is associated with a 5-year survival rate of only 10%. Survival is related to tumour grade and to the number of pelvic lymph nodes involved; furthermore, complete lymphadenectomy may contribute to improved patient survival. Effective treatment programmes for stage D1 bladder cancer are lacking and efforts should be directed toward developing treatment protocols that combine radical cystectomy and meticulous pelvic node dissection with an effective adjuvant systemic treatment programme.
SAFETY OF BILATERAL HIP RECONSTRUCTION IN CHILDREN WITH CEREBRAL PALSY

Purpose The aim of this study was to identify if perioperative outcomes were different in patients with cerebral palsy undergoing unilateral or bilateral hip reconstruction. Method All consecutive hip reconstructions for cerebral palsy performed by the senior author (FNT) within a tertiary-referral centre were identified between January 2012 and July 2016. Patients were stratified by age, gender, GMFCS and side of procedure. Length of surgery, pre- and post- operative haemoglobin, length of stay and immediate post-operative complications were measured. Results 158 procedures were performed; 96 bilateral and 62 unilateral (37 left, 25 right). In bilateral procedures, operative time was 14 minutes longer (p=0.07) and haemoglobin decrease was 1.85g/l greater (p=0.34) with equivalent length of stay (average 6.4 days) and complication rate when compared to those undergoing unilateral procedures. Irrespective of procedure, those with a GMFCS level V had a longer length of stay (p Conclusion No significant differences were noted in the outcome measures when comparing unilateral and bilateral hip reconstructions in our group of patients with cerebral palsy. This suggests that concurrent prophylactic surgical management of the radiologically stable hip is a safe surgical option in this high-risk group of paediatric patients in an appropriate tertiary care setting with multidisciplinary team support.
Pilot Study Assessing the Use of High-Density Polyethylene (Su-Por®) for Tube Shunt Patch Grafts

PURPOSE To assess the viability of a manufactured high-density polyethylene patch graft material (Su-Por) for prevention of tube shunt exposure. MATERIALS AND METHODS Retrospective review of the first 11 patients from the Wills Eye Hospital Glaucoma Service to receive the high-density polyethylene patch graft during tube shunt surgery. RESULTS Four patients (36.3%) experienced an extrusion of the Su-Por patch without a leak within 2.5 months of postoperative follow-up. All 4 patients developed either symptomatic or progressive extrusion. Operative repair was completed with Su-Por removal and replacement with a new human donor patch graft. No patient developed any sign of infection despite the extrusions. The remaining 7 patients had an uneventful postoperative course and continue to have no complications from the Su-Por patch with 9 months of follow-up. CONCLUSIONS Given the high rate of extrusion of the Su-Por graft, this material seems to be an inadequate alternative for covering tube shunts. Harvested human tissue or other more flexible, manufactured grafts remain the standard of care for covering tube shunts.
Private Equity and Financial Fragility during the Crisis

Do private equity firms contribute to financial fragility during economic crises? We find that during the 2008 financial crisis, PE-backed companies increased investments relative to their peers, while also experiencing greater equity and debt inflows. The effects are stronger among financially constrained companies and those whose private equity investors had more resources at the onset of the crisis. PE-backed companies consequentially experienced higher asset growth and increased market share during the crisis.
Bibliometric Analysis of Female Authorship Trends and Collaboration Dynamics over JBMR®'s 30-Year History†

In academia, authorship is considered a currency and is important for career advancement. As the Journal of Bone and Mineral Research (JBMR) is the highest-ranked journal in the field of bone, muscle, and mineral metabolism and is the official publication of the American Society for Bone and Mineral Research, we sought to examine authorship changes over JBMR's 30-year history. Two bibliometric methods were used to collect the data. The "decade method" included all published manuscripts throughout 1 year in each decade over the past 30 years starting with the inaugural year, yielding 746 manuscripts for analysis. The "random method" examined 10% of published manuscripts from each of the 30 years, yielding 652 manuscripts for analysis. Using both methods, the average number of authors per manuscript, numerical location of the corresponding author, number of collaborating institutions, number of collaborating countries, number of printed manuscript pages, and the number of times each manuscript was cited all significantly increased between 1986 and 2015 (p < 10-4 ). Using the decade method, there was a significant increase in the percentage of female first authors over time from 35.8% in 1986 to 47.7% in 2015 (p = 0.02), and this trend was confirmed using the random method. The highest percentage of female first authors in 2015 was in Europe (60.0%), and Europe also had the most dramatic increase in female first authors over time (more than double in 2015 compared with 1986). Likewise, the overall number of female corresponding authors significantly increased during the past 30 years. With the increasing demands of publishing in academic medicine, understanding changes in publishing characteristics over time and by geographical region is important. These findings highlight JBMR's authorship trends over the past 30 years and demonstrate those countries having the most changes and where challenges still exist. © 2017 American Society for Bone and Mineral Research.
Widespread Utilization of Passive Energy Recapture in Swimming Medusae

ABSTRACT Recently, it has been shown that some medusae are capable of swimming very efficiently, i.e. with a low cost of transport, and that this is in part due to passive energy recapture (PER) which occurs during bell relaxation. We compared the swimming kinematics among a diverse array of medusae, varying in taxonomy, morphology and propulsive and foraging modes, in order to evaluate the prevalence of PER in medusae. We found that while PER was common among taxa, the magnitude of the contribution to overall swimming varied greatly. The ability of medusae to utilize PER was not related to morphology and swimming performance but was controlled by their swimming kinematics. Utilizing PER required the medusae to pause after bell expansion and individuals could modulate their PER by changing their pause duration. PER can greatly enhance swimming efficiency but there appear to be trade-offs associated with utilizing PER.
Deconstruction Monitoring of a Steel Truss Bridge

A research study was performed on a steel through-truss bridge more than 80 years of age that was being taken out of service. The main objective of the project was to learn as much as possible about the bridge and to further the state of knowledge about the behavior of steel truss bridges. The study began with a review of the existing condition and load testing of the structure. The main experiment was to monitor the truss members during deconstruction to identify the intrinsic forces present when the bridge was still in service. Those measurements were then compared with simulation results from a finite element model and the original design drawings. This study produced two main conclusions about steel through-truss behavior. First, it was found that the fracture-critical lower chord was redundant because of an adequate alternate load path provided by the floor system. This redundancy was identified through load testing of the structure as well as from numerical simulation results. The floor system was f...
Approximations for High Dimensional Commodity and Energy Merchant Operations Models

Merchant operations is an approach to manage commodity and energy conversion assets modeled as real options. Firms operate networks of such assets, e.g., multiple wind or solar farms that generate electricity at different geographical locations, may be coupled with local grid-level energy storage facilities, and are connected to various wholesale power markets via capacitated transmission lines. The corresponding models are typically intractable. This work describes methods to compute approximate operating policies and assess their optimality gaps for such models. These approximations extend techniques developed for models of single commodity and energy conversion assets.
THE UNSTABLE KNEE: PREVENTION AND MANAGEMENT

A total knee replacement (TKR) with instability is one in which the supporting soft tissues have failed or are unable to function due to component size and/or position. Instability following TKR can lead to the need for surgery in 10–22% of revision cases. Patients may complain of symptoms of giving way, difficulty climbing stairs, and the sensation that their knee may buckle under stress. Physical findings may include soft-tissue tenderness in the peripatellar and pes anserine regions, recurrent joint effusions, and joint laxity. The cause of instability after TKR should be determined pre-operatively so the problem may be corrected at the time of revision. Instability after TKR may be due to component loosening, ligament rupture/incompetence, component malposition, mismatched flexion/extension gaps, or failure to correct ligament imbalance at the time of the index procedure. A common scenario after a cruciate-retaining TKR is that of PCL rupture, thus leading to instability in flexion and excessive posterior translation of the tibia. Other scenarios leading to TKR instability are pre-operative valgus alignment with MCL stretching, resulting in the post-operative recurrence of medial instability; or excessive resection of the posterior femoral condyles from undersizing of the femoral component, leading to laxity in flexion. The treatment of instability after TKR generally requires component revision and balancing of the flexion and extension gaps. Isolated ligament reconstruction is not successful in the setting of a prosthetic joint due to the lack of inherent joint stability. At the time of revision, the surgeon must carefully assess the flexion gap; often posterior femoral augments must be used to upsize the femoral component and tighten the flexion space relative to the extension space; for this reason, isolated polyethylene exchange is not successful for flexion instability. For instability in the varus/valgus plane, rebalancing the knee by performing ligament releases and using a more stabilizing polyethylene insert may by sufficient. The results of revision TKR for instability has been successful in the majority of cases, decreasing the symptoms of giving way and difficulty stairclimbing. A careful assessment of the varus/valgus stability of the prosthetic knee and the flexion/extension spaces at the time of revision TKR, along with the use of augments and more stabilised articulations, is mandatory in order to achieve good results.
Practical Machine Learning for Cloud Intrusion Detection: Challenges and the Way Forward

Operationalizing machine learning based security detections is extremely challenging, especially in a continuously evolving cloud environment. Conventional anomaly detection does not produce satisfactory results for analysts that are investigating security incidents in the cloud. Model evaluation alone presents its own set of problems due to a lack of benchmark datasets. When deploying these detections, we must deal with model compliance, localization, and data silo issues, among many others. We pose the problem of "attack disruption" as a way forward in the security data science space. In this paper, we describe the framework, challenges, and open questions surrounding the successful operationalization of machine learning based security detections in a cloud environment and provide some insights on how we have addressed them.
Automatic splicing for hand and body animations

We propose a solution to a new problem in animation research: how to use human motion capture data to create character motion with detailed hand gesticulation without the need for the simultaneous capture of hands and the full-body. Occlusion and a difference in scale make it difficult to capture both the detail of the hand movement and unrestricted full-body motion at the same time. With our method, the two can be captured separately and spliced together seamlessly with little or no user input required. The algorithm relies on a novel distance metric derived from research on gestures and uses a two-pass dynamic time warping algorithm to find correspondence between the hand and full-body motions. In addition, we provide a method for supplying user input, useful to animators who want more control over the integrated animation. We show the power of our technique with a variety of common and highly specialized gesticulation examples.
Birth plans-Impact on mode of delivery, obstetrical interventions, and birth experience satisfaction: A prospective cohort study.

Objective To examine whether the presence of a birth plan was associated with mode of delivery, obstetrical interventions, and patient satisfaction. Methods This was a prospective cohort study of singleton pregnancies greater than 34 weeks’ gestation powered to evaluate a difference in mode of delivery. Maternal characteristics, antenatal factors, neonatal characteristics, and patient satisfaction measures were compared between groups. Differences between groups were analyzed using chi-squared for categorical variables, Fisher exact test for dichotomous variables, and Wilcoxon rank sum test for continuous or ordinal variables. Results Three hundred women were recruited: 143 (48%) had a birth plan. There was no significant difference in the risk of cesarean delivery for women with a birth plan compared with those without a birth plan (21% vs 16%, adjusted odds ratio [adjOR] 1.11 [95% confidence interval (CI) 0.61-2.04]). Women with a birth plan were 28% less likely to receive oxytocin (P < .01), 29% less likely to undergo artificial rupture of membranes (P < .01), and 31% less likely to have an epidural (P < .01). There was no difference in the length of labor (P = .12). Women with a birth plan were less satisfied (P < .01) and felt less in control (P < .01) of their birth experience than those without a birth plan. Conclusion Women with and without a birth plan had similar odds of cesarean delivery. Though they had fewer obstetrical interventions, they were less satisfied with their birth experience, compared with women without birth plans. Further research is needed to understand how to improve childbirth-related patient satisfaction.
Measuring the impacts of cash settlement: A stochastic volatility approach

Abstract Prior to 1986, any opening position on feeder cattle futures contract must be settled with physical delivery after the last trading day. Due to dwindling commercial interests, Chicago Mercantile Exchange (CME) subsequently replaced the system with the cash settlement method. It was argued that cash settlement would help improve the convergence between cash and futures prices and reduce the basis variability. In this paper, we adopted stochastic volatility (SV) models to investigate this conjecture. The models allow for time-varying volatility. We found strong evidence of reduction in basis and in basis variance after cash settlement. Moreover, cash settlement induced a change in the structural relationship between cash and futures prices. The futures market has become more efficient after the change in settlement methods.
Field-Theoretic Simulations of the Distribution of Nanorods in Diblock Copolymer Thin Films.

Using block copolymer microphases to guide the self-assembly of nanorods in thin films can give rise to polymeric materials with unique optical, thermal, and mechanical properties beyond those found in neat block copolymers. Often the design and manufacture of these materials require exquisite control of the nanorod distribution, which is experimentally challenging due to the large parameter space spanned by this class of materials. Simulation approaches, on the other hand, can access the thermodynamics that contribute to the nanorod distribution and hence offer valuable guidance toward the design and manufacture of the materials. In this work, we employ complex Langevin field-theoretic simulations to examine the thermodynamic forces that govern the assembly of nanorods in thin films of block copolymers with a particular focus on vertically oriented cylindrical and lamellar domains. Our simulations show that the nanorod geometry, the substrate selectivity for the distinct blocks of the copolymer, and the ...
Exploring perceptions and experiences of patients who have chronic pain as state prescription opioid policies change: a qualitative study in Indiana

Objectives The misuse and abuse of prescription opioids (POs) is an epidemic in the USA today. Many states have implemented legislation to curb the use of POs resulting from inappropriate prescribing. Indiana legislated opioid prescribing rules that went into effect in December 2013. The rules changed how chronic pain is managed by healthcare providers. This qualitative study aims to evaluate the impact of Indiana’s opioid prescription legislation on the patient experiences around pain management. Setting This is a qualitative study using interviews of patient and primary care providers to obtain triangulated data sources. The patients were recruited from an integrated pain clinic to which chronic pain patients were referred from federally qualified health clinics (FQHCs). The primacy care providers were recruited from the same FQHCs. The study used inductive, emergent thematic analysis. Participants Nine patient participants and five primary care providers were included in the study. Results Living with chronic pain is disruptive to patients’ lives on multiple dimensions. The established pain management practices were disrupted by the change in prescription rules. Patient–provider relationships, which involve power dynamics and decision making, shifted significantly in parallel to the rule change. Conclusions As a result of the changes in pain management practice, some patients experienced significant challenges. Further studies into the magnitude of this change are necessary. In addition, exploring methods for regulating prescribing while assuring adequate access to pain management is crucial.
Neurodevelopmental Outcomes at Two Years of Age for Premature Infants Diagnosed With Neonatal Obstructive Sleep Apnea.

Study Objectives:Neurocognitive deficits have been shown in school-aged children with sleep apnea. The effect of obstructive sleep apnea (OSA) on the neurodevelopmental outcome of preterm infants i...
Loss of Drosophila Mei-41/ATR Alters Meiotic Crossover Patterning

Meiotic crossovers must be properly patterned to ensure accurate disjunction of homologous chromosomes during meiosis I. Disruption of the spatial distribution of crossovers can lead to nondisjunction, aneuploidy, gamete dysfunction, miscarriage, or birth defects. One of the earliest identified genes involved in proper crossover patterning is Drosophila mei-41, which encodes the ortholog of the checkpoint kinase ATR. Analysis of hypomorphic mutants suggested the existence of crossover patterning defects, but it was not possible to assess this in null mutants because of maternal-effect embryonic lethality. To overcome this lethality, we constructed mei-41 null mutants in which we expressed wild-type Mei-41 in the germline after completion of meiotic recombination, allowing progeny to survive. We find that crossovers are decreased to about one-third of wild-type levels, but the reduction is not uniform, being less severe in the proximal regions of chromosome 2L than in medial or distal 2L or on the X chromosome. None of the crossovers formed in the absence of Mei-41 require Mei-9, the presumptive meiotic resolvase, suggesting that Mei-41 functions everywhere, despite the differential effects on crossover frequency. Interference appears to be significantly reduced or absent in mei-41 mutants, but the reduction in crossover density in centromere-proximal regions is largely intact. We propose that crossover patterning is achieved in a stepwise manner, with the crossover suppression related to proximity to the centromere occurring prior to and independently of crossover designation and enforcement of interference. In this model, Mei-41 has an essential function in meiotic recombination after the centromere effect is established but before crossover designation and interference occur.
Big Data Analytics for Rapid, Impactful, Sustained, and Efficient (RISE) Humanitarian Operations

There has been a significant increase in the scale and scope of humanitarian efforts over the last decade. Humanitarian operations need to be - rapid, impactful, sustained and efficient (RISE). Big data offers many opportunities to enable RISE humanitarian operations. In this paper, we introduce the role of big data in humanitarian settings and discuss data streams which could be utilized to develop descriptive, prescriptive and predictive models to significantly impact the lives of people in need.
Scanning Tunneling Microscopy Studies of InGaN Growth by Molecular Beam Epitaxy

InGaN alloys with indium compositions ranging from 0–40% have been grown by molecular beam epitaxy. The dependence of the indium incorporation on growth temperature and group III/group V ratio has been studied. Scanning tunneling microscopy images, interpreted using first-principles theoretical computations, show that there is strong indium surface segregation on InGaN. Based on this surface segregation, a qualitative model is proposed to explain the observed indium incorporation dependence on the growth parameters.
Reconciling Results on Racial Differences in Police Shootings

Police use of force – particularly lethal force – is one of the most divisive issues of the twenty-first century. To understand the nexus of race, criminal justice, and police brutality, academics and journalists have begun to amass impressive datasets on Officer-Involved-Shootings (OIS). I compare the data and methods of three investigative journalism articles and two publications in the social sciences on a set of five rubrics and conclude that the stark differences between their findings are due to differences in what qualifies for a valid research design and not underlying differences in the datasets.
Managing atrial fibrillation to prevent stroke

Atrial fibrillation (AF) is an important risk factor of stroke and contributes to 20% of strokes in the UK; however, with appropriate intervention, the risk can be reversed. For patients with a diagnosis of non-valvular atrial fibrillation, therapeutic anticoagulation is the treatment of choice. The National Institute for Health and Care Excellence AF guidelines recommend that every patient should receive appropriate treatment and a personalised package of care; empowering them to take ownership of their healthcare needs and make informed and educated decisions about their health. However, there are still a significant proportion of patients that are not receiving effective therapeutic treatment. This article explores the current best practice requirements for AF stroke prevention, considering clinical need for diagnosis; individualised risk assessment for appropriate treatment; progress in anticoagulation options; and delivery of a patient-centred package of care in today's practice.
Peripheral, intrareceptor inhibition in mosquito olfaction

How chemical signals are integrated at the peripheral sensory system of insects is still an enigma. Here we show that when coexpressed with Orco in Xenopus oocytes, an odorant receptor from the southern house mosquito, CquiOR32, generated inward (regular) currents when challenged with cyclohexanone and methyl salicylate, whereas eucalyptol and fenchone elicited inhibitory (upward) currents. Responses of CquiOR32-CquiOrco-expressing oocytes to odorants were reduced in a dose-dependent fashion by coapplication of inhibitors. This intrareceptor inhibition was also manifested in vivo in fruit flies expressing the mosquito receptor CquiOR32, as well in neurons on the antennae of the southern house mosquito. Likewise, an orthologue from the yellow fever mosquito, AaegOR71, showed intrareceptor inhibition in the Xenopus oocyte recording system and corresponding inhibition in antennal neurons. Intrareceptor inhibition was also manifested in mosquito behavior. Blood-seeking females were repelled by methyl salicylate, but repellence was significantly reduced when methyl salicylate was coapplied with eucalyptol.
Detecting stellar lensing of gravitational waves with ground-based observatories

We investigate the ability of ground-based gravitational-wave observatories to detect gravitational-wave lensing events caused by stellar mass lenses. We show that LIGO and Virgo possess the sensitivities required to detect lenses with masses as small as $\ensuremath{\sim}30\text{ }\text{ }{M}_{\ensuremath{\bigodot}}$ provided that the gravitational wave is observed with a signal-to-noise ratio of $\ensuremath{\sim}30$. Third-generation observatories will allow detection of gravitational-wave lenses with masses of $\ensuremath{\sim}1\text{ }\text{ }{M}_{\ensuremath{\bigodot}}$. Finally, we discuss the possibility of lensing by multiple stars, as is the case if the gravitational radiation is passing through a galactic nucleus or a dense star cluster.
The Gender Unemployment Gap

Abstract The gender unemployment gap, the difference between female and male unemployment rates, was positive until the early 1980s. This gap disappeared after 1983, except during recessions, when men's unemployment rate has always exceeded women's. Using a calibrated three-state search model, we show that the convergence in female and male labor force attachment accounts for most of the closing of the gender unemployment gap. Evidence from nineteen OECD countries is consistent with this finding. We show that gender differences in industry composition are the main source of the cyclicality of the unemployment gap.
A lower vat rate on electricity in Portugal: Towards a cleaner environment, better economic performance, and less inequality

Abstract This article addresses the budgetary, economic, distributional and environmental impact of increasing the VAT on electricity in Portugal. The analysis is carried out in the context of a new multi-sector, multi-household, dynamic general equilibrium model. Simulation results suggest that a permanent increase from 6% to 23% improves the public budget and, albeit marginally, CO2 emissions, but it leads to detrimental economic and distributional effects. As the economy in Portugal begins to recover after the Great Financial Crisis, and the budgetary situation becomes less constraining, pressure is mounting for this VAT increase to be reversed. This mixed bag of results is an important element for the debate. Reverting to a lower VAT is desirable, as it would improve economic performance and have positive distributional effects. The question is how to compensate for the loss of tax revenues. To offset the adverse budgetary effects of a lower VAT, we consider several revenue raising strategies. Our simulation results suggest that an offsetting increase in either the general VAT tax rate or the tax on petroleum products would yield more favorable effects from all relevant perspectives – economic, distributional, and environmental while mostly keeping intact the budgetary benefits.
Reading Graciliano Ramos in the United States

Os estudos norte-americanos sobre a obra de Graciliano Ramos tem se detido sobre inumeraveis assuntos e nao ha duvida de que seus livros terao um interesse permanente aqui. Ao mesmo tempo, e apesar do corpo substancial de escrita erudita sobre os textos de Graciliano, nao existe um estudo sobre a historia de sua recepcao nos Estados Unidos, assunto que sera o enfoque deste ensaio. Tal discussao sera util porque pode revelar momentos historicos definidores, tendencias ideologicas e formacoes culturais que influenciaram a maneira pela qual selecionamos, lemos, e escrevemos sobre literatura.
Shareholder Activism in REITs

Conventional wisdom suggests that shareholder activism in REITs is less prevalent than in other (non‐REIT) public firms because of stronger barriers to hostile takeovers and potentially less undervaluation. Our results, however, suggest that the conventional wisdom does not hold. Specifically, we find that in 2006–2015, Equity REITs (EREITs) are as likely to be targeted by shareholder activists as non‐EREITs. We also find that shareholder campaign characteristics and determinants, as well as their value consequences, appear similar for EREITs and non‐EREITs. Given that this is the first study to examine shareholder activism in REITs, we raise several questions for future research.
Regulation of Constitutive Tip110 Expression in Human Cord Blood CD34+ Cells Through Selective Usage of the Proximal and Distal Polyadenylation Sites Within the 3'Untranslated Region.

Tip110 plays important roles for stem cell pluripotency and hematopoiesis. However, little is known about the regulatory mechanisms of Tip110 expression in this process. In this study, we first sho...
Loss Aversion, Intellectual Inertia, and a Call for a More Contrarian Science: A Reply to Simonson & Kivetz and Higgins & Liberman

Higgins and Liberman (2018) and Simonson and Kivetz (2018) offer scholarly and stimulating perspectives on loss aversion and the implications for the sociology of science of its acceptance as a virtual law of nature. In our view, Higgins and Liberman (2018) largely complement our conclusion that the empirical evidence does not support loss aversion. Moreover, in alignment with our call for a contextualized perspective, they provide an excellent discourse on how a more nuanced view of reference points and consumers’ regulatory focus enriches our understanding of the psychological impact of losses and gains. Simonson and Kivetz (2018) approached our perspective with skepticism, and, while they retain some skepticism, they express agreement on the larger point that loss aversion has been accepted too uncritically. Both commentaries point to a need for a critical reevaluation of prevailing paradigms. Here, we build on these perspectives, as well as our experience working on the topic of loss aversion, to call for structural changes to facilitate scholarly debate on science’s status quo.
Universal Convergence of the Specific Volume Changes of Globular Proteins Upon Unfolding

Both pressure and temperature are important environmental variables, and in order to obtain a complete understanding of the mechanisms of protein folding, it is necessary to determine how protein stability is dependent on these fundamental thermodynamic parameters. Although the temperature dependence of protein stability has been widely explored, the dependence of protein stability on pressure is not as well studied. In this paper, we report the results of the direct thermodynamic determination of the change in specific volume (ΔV/V) upon protein unfolding, which defines the pressure dependence of protein stability, for five model proteins (ubiquitin, eglin c, ribonuclease A, lysozyme, and cytochrome C). We have shown that the specific volumetric changes upon unfolding for four of the proteins (ubiquitin, eglin c, ribonuclease A, lysozyme) appear to converge to a common value at high temperature. Analysis of various contributions to the change in volume upon protein unfolding allowed us to put forth the hypothesis that the change in volume due to hydration is very close to zero at this temperature, such that ΔV/V is defined largely by the total volume of cavities and voids within a protein, and that this is a universal property of all small globular proteins without prosthetic groups. To test this hypothesis, additional experiments were performed with variants of eglin c that had site-directed substitutions at two buried positions, in order to create an additional cavity in the protein core. The results of these experiments, coupled with the structural analysis of cytochrome c showing a lower packing density compared to the other four proteins, provided further support for the hypothesis. The deviation of the high-temperature ΔV value from the convergence value can be used to experimentally determine the size of the excess cavities in proteins.
A Novel Method for the In-Depth Multimodal Analysis of Student Learning Trajectories in Intelligent Tutoring Systems

Temporal analyses are critical to understanding learning processes, yet understudied in education research. Data from different sources are often collected at different grain sizes, which are difficult to integrate. Making sense of data at many levels of analysis, including the most detailed levels, is highly time-consuming. In this paper, we describe a generalizable approach for more efficient yet rich sensemaking of temporal data during student use of intelligent tutoring systems. This multi-step approach involves using coarse-grain temporality — learning trajectories across knowledge components — to identify and further explore “focal” moments worthy of more fine-grain, context-rich analysis. We discuss the application of this approach to data collected from a classroom study in which students engaged in a Chemistry Virtual Lab tutoring system. We show that the application of this multi-step approach efficiently led to interpretable and actionable insights while making use of the richness of the available data. This method is generalizable to many types of datasets and can help handle large volumes of rich data at multiple levels of granularity. We argue that it can be a valuable approach to tackling some of the most prohibitive methodological challenges involved in temporal learning analytics
Monitoring of cyclic steam stimulation by inversion of surface tilt measurements

Abstract Temperature and pressure changes associated with the cyclic steam stimulation (CSS) used in heavy oil production from sands are accompanied by significant deformation. Inversion of induced...