cssi/SciSciGPT-SciSciNet huggingface dataset:
Lifting the Veil: Foundations for a Gender-Inclusive Paradigm of Intimate Partner Violence

This chapter details the ongoing debate between the gender paradigm and the family violence paradigm of intimate partner violence (IPV). The gender paradigm of IPV argues that domestic violence is the inevitable consequence of patriarchy and cleaves men and women along a mutually exclusive aggressor → victim binary. The family violence paradigm rejects the foundational assumption that violence and aggression are innately gendered and advocates the employment of social learning models to provide a more inclusive theoretical foundation for understanding IPV. Empirical findings throughout the past three decades have repeatedly found that women aggress against their intimate partners at approximately the same rate as men and, importantly, not exclusively as a form of self-defense. The sovereignty of the gender paradigm has rendered female perpetrators a relatively invisible population and obscures the routes toward ensuring their successful treatment in batterer intervention programs (BIPs) throughout the country. This chapter will outline the theoretical inconsistencies subsumed within the gender paradigm and present both theoretical and empirical substantiation for the family violence models of IPV. Our intent is to challenge the social and legal dominance of the gender paradigm and to advance the nuanced and encompassing family violence model for IPV.
Epstein-Barr Virus MicroRNA Expression Increases Aggressiveness of Solid Malignancies

The Cancer Genome Atlas (TCGA) microRNA (miRNA) initiative has revealed a pivotal role for miRNAs in cancer. Utilizing the TCGA raw data, we performed the first mapping of viral miRNA sequences within cancer and adjacent normal tissues. Results were integrated with TCGA RNA-seq to link the expression of viral miRNAs to the phenotype. Using clinical data and viral miRNA mapping results we also performed outcome analysis. Three lines of evidence lend credence to an active role of viral miRNAs in solid malignancies. First, expression of viral miRNA is consistently higher in cancerous compared to adjacent noncancerous tissues. Second, viral miRNA expression is associated with significantly worse clinical outcome among patients with early stage malignancy. These patients are also featured by increased expression of PD1/PD-L1, a pathway implicated in tumors escaping immune destruction. Finally, a particular cluster of EBV-miRNA (miR-BART2, miR-BART4, miR-BART5, miR-BART18, and miR-BART22) is associated with expression of cytokines known to inhibit host response to cancer. Quantification of specific viral miRNAs may help identify patients who are at risk of poor outcome. These patients may be candidates for novel therapeutic strategies incorporating antiviral agents and/or inhibitors of the PD-1/PD-L1 pathway.
Uncertainty Considerations in Calibration and Validation of Hydrologic and Water Quality Models

Abstract. Hydrologic and water quality models (HWQMs) are increasingly used to support decisions on various environmental issues and policy directions for present and future scenarios, at scales varying from watershed to continental levels. Uncertainty associated with such models may affect the ability of the models to accurately evaluate the response of complex systems, leading to misguided assessments and risk management decisions. Current well-known HWQMs contain numerous input parameters, many of which are not known with certainty, and in other cases model users can hardly recognize the genesis of uncertainty. Uncertainty in data, model structure, and model parameters can propagate throughout model runs, causing the model output to substantially deviate from the expected response of the natural system. Various uncertainty assessment methods have been used with different HWQMs, creating concerns about an adequate approach for handling uncertainty in these models and how such an approach can be implemented across various discretization complexities and scales. In this article, our primary intention is to review uncertainty in the currently used HWQMs and to provide guidance and useful information for researchers and investigators. In this regard, we explore the genesis of uncertainty in hydrologic and water quality modeling (i.e., spatiotemporal scales, model representation, model discretization, model parameterization) and provide strategies for assessing uncertainty in hydrologic and water quality modeling on local and global scales when interpreting the model output.
A simple device for demonstrating Duncker's induced movement.

Summary.-A device for demonstrating Duncker's induced movement (IM) is described. A black-bordered vertically-oriented rectangle enclosing a dot is presented on each side of a display, which is rotated on a record turntable. Upon rotation an objectively stationary point is seen as oscillating vertically (IM) in the direction opposite that shown by the rectangles. Duncker (1950) observed that, under certain conditions, a single stationary point appears to move in the direction opposite that of an objectively moving background. He named this effect induced movement (IM). Such phenomenal movement is often observed in daily life, for example, the IM of the moon during movement of clouds, the upstream IM of objects in fast moving waterways, and the IM of passing distant terrain seen moving in the direction travelled by the observer. Duncker's procedilres were somewhat complicated and utilized more than one piece of equipment. The purpose of this paper is to describe a simple device which demonstrates IM and some of its properties. The device conslscs of a record nirntable driven by a variable speed motor which rotates a vert~cal display to a maximum speed of 100 rpm (see Fig. 1).
Ecology of the American Dog Tick, Dermacentor variabilis, in a Study Area in Virginia. 2. Distribution in Relation to Vegetative Types.

The relationship between distribution of Dermacentor variabilis (Say) and vegetation was studied. Average tick capture frequency was compared with vegetation classified by 2 different methods. Immature tick capture frequency was highly aggregated with greatest numbers in the old field-forest ecotone. Adult tick distribution was much less aggregated, though these ticks also were collected more frequently in the field-forest ecotone. Comparisons of tick distribution with forest vegetation (exclusive of the ecotone) classified according to density of various height categories revealed little difference between low and medium height deciduous types, though both of these had more ticks than other forest types. In a comparison of tick distribution with forest vegetation classified according to tree species composition, immature tick capture frequency was greatest in the moist-mesic mixed pine-deciduous and mixed lowland types (3-year average) while adult tick capture frequency was greatest in the drier mixed upland and hickory dominant forest areas. The mixed oak type, which was in the most advanced stage of succession, i.e., approaching climax, had low yields of all D. variabilis life stages. Hypotheses to explain the reasons for these differences are discussed. The results of comparisons of capture frequencies of radioisotope-tagged ticks in relation to vegetation were similar to those for unmarked (wild ticks) with respect to the field forest ecotone, but not among the forest types. The use of radioisotope-tagged ticks to study the relationship between tick distribution and vegetation appears to have been useful where adequate samples were obtained (e.g., field-forest ecotone) and is of interest because the results can be related to the number of individuals released.
A Bernoulli mean estimate with known relative error distribution

Suppose that are independent identically distributed Bernoulli random variables with mean p, so and . Any estimate of p has relative error . This paper builds a new estimate of p with the remarkable property that the relative error of the estimate does not depend in any way on the value of p. This allows the easy construction of exact confidence intervals for p of any desired level without needing any sort of limit or approximation. In addition, is unbiased. For ∊ and δ in (0, 1), to obtain an estimate where , the new algorithm takes on average at most samples. It is also shown that any such algorithm that applies whenever requires at least samples on average. The same algorithm can also be applied to estimate the mean of any random variable that falls in . The used here employs randomness external to the sample, and has a small (but nonzero) chance of being above 1. It is shown that any nontrivial where the relative error is independent of p must also have these properties. Applications of this methodology include finding exact p-values and randomized approximation algorithms for # P complete problems. © 2016 Wiley Periodicals, Inc. Random Struct. Alg., 2016
Preparation and performance of surface modification of non-woven fabric by PVA(polyvinyl alcohol)

The surface hydrophilic modification of polypropylene non-woven fabric(NWF)by the film of PVA(polyvinyl alcohol)and GA cross-linking to be immobilized on the NWF surface by dip-coating was researched.Chemical structures and morphological changes of the NWF samples surface were characterized in detail by attenuated total reflectance Fourier transform infrared(FTIR-ATR)and scanning electronic microscope(SEM).The effect of concentrations of PVA/GA on film immobilization degree and on hydrophilicity was discussed,and mechanical performance of NWF was tested.Results reveal that polar groups such as —OH,—C—O—C— are introduced to the NWF surface,hydrophilicity is improved,and water static contact angle is decreased from 86°±1° to 43°±3°.With increasing PVA concentration,surface hydrophilicity is increased.PVA modification enhances mechanical performance of NWF,tensile strength and tear resistance are increased by 25.0% and 21.6% respectively.
OCT elastography of the vascular tissue-importance of cross-correlation kernel size

In this paper we evaluate OCT elastography as a method for assessing elastic properties of vascular tissue. Phantoms and in vitro pulmonary arteries were examined to assess speckle modulation and measure the displacements and strain maps.
Pictorial Concreteness and Mode of Elaboration in Children's Learning.

Abstract Paired-associate learning by children was investigated as a function of age (4 vs 7 yr), stimulus type (line drawing, color photograph, or object) and mode of elaboration (visual or verbal). Photographs and objects were associated with more learning than drawings at both ages and with both types of mediational elaboration. Only indirect evidence could be obtained for the prediction that differences among the three types of pictorial stimuli decrease with age. A previously reported Age × Elaboration interaction suggesting a relative disadvantage of visual elaboration for the younger children was not replicated.
From English to Chinese, Japanese, and Russian: extending research visibility with language translations of a conference slide presentation.

Objective: The research demonstrates that a conference slide presentation translated into non-English languages reaches significantly larger and different audiences than an English presentation alone. Methods: The slides of a presentation from the Medical Library Association annual meeting were translated from English to Chinese, Japanese, and Russian and posted along with the English version to SlideShare, an open slide-hosting website. View counts, traffic sources, and geographic origins of the traffic for each language version were tracked over a twenty-two-month period. Results: Total view counts for all 4 language versions amounted to 3,357 views, with the Chinese version accounting for 71% of the total views. The trends in view counts over time for the Japanese, Russian, and English versions were similar, with high interest at the beginning and a rapid drop and low level of viewing activity thereafter. The pattern of view counts for the Chinese version departed considerably from the other language versions, with very low activity at the beginning but a sharp rise 10 months later. This increase in activity was related to access to the presentations via a Taiwanese website that embedded the SlideShare website code. Conclusions: Language translation can be a difficult and time-consuming task. However, translation of a conference slide presentation with limited text is an achievable activity and engages an international audience for information that is often not noticed or lost. Although English is by far the primary language of science and other disciplines, it is not necessarily the first or preferred language of global researchers. By offering appropriate language versions, the authors of presentations can expand the reach of their work.
Sustained impairment of respiratory function and swim performance following acute oil exposure in a coastal marine fish

Acute exposure to crude oil polycyclic aromatic hydrocarbons (PAH) can severely impair cardiorespiratory function and swim performance of larval fish; however, the effects of acute oil exposure on later life stages and the capacity for subsequent recovery is less clear. Red drum (Sciaenops ocellatus) is an economically important apex predator native to the Gulf of Mexico, which was directly exposed to the 2010 Deep Water Horizon (DWH) oil spill. Here we examine impact and recovery of young adult red drum from exposure to concentrations of 0, 4.1, and 12.1μgL-1 ΣPAH50 naturally weathered oil-water accommodated fractions (geometric mean), which are well within the range of concentrations measured during the DWH incident. We focused on aerobic scope (ASc), burst- and critical swimming speeds (Uburst and Ucrit), cost of transport (COT), as well as the capacity to repay oxygen debt following exhaustive exercise (EPOC), which are critical parameters for success of all life stages of fishes. A 24h acute exposure to 4.1μgL-1 ΣPAH caused a significant 9.7 and 12.6% reduction of Uburst and Ucrit respectively, but no change in ASc, COT or EPOC, highlighting a decoupled effect on the respiratory and swimming systems. A higher exposure concentration, 12.1μgL-1 ΣPAH, caused an 8.6 and 8.4% impairment of Uburst and Ucrit, as well as an 18.4% reduction in ASc. These impairments persisted six weeks post-exposure, suggesting that recorded impacts are entrenched. Large predatory fishes are critically dependent on the cardiorespiratory and swimming systems for ecological fitness, and long-term impairment of performance due to acute oil exposure suggests that even acute exposure events may have long lasting impacts on the ecological fitness of affected populations.
Vosaroxin in relapsed/refractory acute myeloid leukemia: efficacy and safety in the context of the current treatment landscape

Treatment for acute myeloid leukemia (AML) generally consists of a combination of cytarabine and an anthracycline. Although induction therapy leads to complete remission (CR) for most patients, refractoriness to chemotherapy or relapse after initial response is associated with poor outcomes. The 1-year survival rates after first relapse have been reported at 29%, declining to 11% at 5 years. Prognosis is particularly poor among older patients whose higher prevalence of unfavorable cytogenetics and high frequency of comorbidities diminish their ability to tolerate intensive chemotherapy. There is no standard of care for relapsed/refractory (R/R) AML, and no new therapies have shown consistently superior outcomes in this setting in over two decades. Vosaroxin is an anticancer quinolone derivative (AQD) that was evaluated in combination with cytarabine for the treatment of R/R AML in the randomized, double-blind, placebo-controlled, phase III VALOR study (n = 711). Compared with placebo/cytarabine, the vosaroxin/cytarabine regimen demonstrated favorable CR rates and survival in patients ⩾60 years of age, with toxicities similar to other AML regimens. Here we review outcomes of recent studies of commonly used chemotherapy regimens for the treatment of R/R AML and evaluate the results of the VALOR trial in the context of the current treatment landscape.
Chinese and European American Undergraduates’ Perceptions of Maternal Warmth and Negativity as Predictors of Self-Esteem and Life Satisfaction:

This study examined whether culture moderated the associations between Chinese and European American undergraduates’ perceptions of parental warmth and negativity, and how these perceptions predict...
Preserving Virtual Memory by Mitigating the Address Translation Wall

The concept of virtual memory is one of the classic computer science abstractions and has long enabled systems that are easy to program and that operate quickly. Today, however, virtual memory faces challenges that pose a threat to the continued progress of computing. This article discusses these threats and presents some promising ways to counter them.
CALCULATION OF SHIP’S ACTIVE BRAKING CHARACTERISTICS

The article considers a new calculation method for determining the ship's maneuvering elements (inertial-braking characteristics) using an alternative approach. Based on the new methodology, the procedure for calculating the inertial-braking parameters of the ship is given. Within the framework of this task, an alternative approach is considered for determining the inertial-braking characteristics of a ship. The article shows that the entire braking process is divided by speed into several elementary sections and it is assumed that in each section the work of the resistance forces and the propeller stop is equal to the work of their average valuesand. And as an alternative method for determining the characteristics of the slowed and accelerated motion of the ship and its characteristics of active braking, theorems on the change in the amount of motion and kinetic energy are used. As a result, expressions of the braking time t and the coasting time S are obtained. Using the obtained expressions, an example of calculating the length and time of the coasting with active braking in the reverse direction from full forward to "full reverse" is given
Finite element evaluation of the newest ISO testing standard for polyethylene total knee replacement liners.

Current treatment for end-stage osteoarthritis is total knee replacement. Given that the number of total knee replacement surgeries is expected to approach 3.48 million by 2030, understanding long-...
Qualitative Cancer Genetic Counseling Research, Part II: Findings from a Exploratory Ethnographic Study in a Cancer Clinic

This is a report of the preliminary findings of a brief exploratory ethnographic study in a cancer diagnosis and treatment clinic. The main research purpose was to explore the meaning of cancer and cancer treatment to patients themselves and to their relatives and close friends. The methods are described in detail in a paper focusing on the experiences of being a novice ethnographer (Peters et al. (2001) J Genet Counsel 10(2):133–150.). The preliminary results of this exploratory fieldwork indicate that the experience of attending a cancer treatment clinic for evaluation and/or treatment is a complex social, emotional as well as medical process for patients and families. Themes with relevance to genetic counselors that emerged from this early observation period included ideas about causes of cancer, the complex nature of families and kinship, coping and support, use of food, and healing. These initial findings have implications for genetic counseling practice and hopefully will stimulate more qualitative social and behavioral research in cancer genetic counseling.
Correlation of theory to wind-tunnel data at Reynolds numbers below 500,000

This paper presents results obtained from two airfoil analysis methods compared with previously published wind tunnel test data at chord Reynolds numbers below 500,000. The analysis methods are from the Eppler-Somers airfoil design/analysis code and from ISES, the Drela-Giles airfoil design/analysis code. The experimental data are from recent tests of the Eppler 387 airfoil in the NASA Langley Low Turbulence Pressure Tunnel. For R ≥ 200,000, lift and pitching moment predictions from both theories compare well with experiment. Drag predictions from both theories also agree with experiment, although to different degrees. The Drela-Giles code also predicts pressure distributions which compare well with the experimental pressure distributions, including those cases with laminar separation bubbles. For Reynolds numbers of 60,000 and 100,000, lift and pitching moment predictions from both theories are in fair agreement with experiment. However, most of the drag predictions from the Eppler-Somers code are accompanied with separation bubble warnings which indicate that the drag predictions are too low. With the Drela-Giles code, there is a large discrepancy between the computed and experimental pressure distributions in cases with laminar separation bubbles, although the drag polar predictions are similar in trend to experiment.
The Promise of Proton Therapy for Central Nervous System Malignancies

Radiation therapy plays a significant role in management of benign and malignant diseases of the central nervous system. Patients may be at risk of acute and late toxicity from radiation therapy due to dose deposition in critical normal structures. In contrast to conventional photon delivery techniques, proton therapy is characterized by Bragg peak dose deposition which results in decreased exit dose beyond the target and greater sparing of normal structure which may reduce the rate of late toxicities from treatment. Dosimetric studies have demonstrated reduced dose to normal structures using proton therapy as compared to photon therapy. In addition, clinical studies are being reported demonstrating safety, feasibility, and low rates of acute toxicity. Technical challenges in proton therapy remain, including full understanding of depth of proton penetration and the biological activity in the distal Bragg peak. In addition, longer clinical follow-up is required to demonstrate reduction in late toxicities as compared to conventional photon-based radiation techniques. In this review, we summarize the current clinical literature and areas of active investigation in proton therapy for adult central nervous system malignancies.
Tarsier: A Light-Weight Framework for Visualizing Gravitational-Wave Transients

The direct observation of gravitational-wave (GW) signals has become one of the most exciting events in this century. However, data analysis for finding signals of gravitational-waves from huge collected data is still a challenge for researchers. In addition, we also found that the researchers cannot easily view and manipulate collected data with mobile devices, such as mobile tablets. Since there is a need to access GW data on a mobile platform, we propose a new mobile framework, Tarsier, that consists of a mobile client as a front-end for data visualization and a flexible web architecture (RESTful APIs, Node.JS and MongoDB) as a back-end to provide data services. This is an ongoing project of undergraduate research, but the current design and results demonstrate a promising direction of applying computer science technologies to the Astro-Physics domain.
Simulation in Urology

In this chapter we have discussed simulation in urology. This relatively new field is an exciting avenue exploring the possibility of allowing trainees to learn new skills and procedures in a controlled environment that does not jeopardize patient health. This is particularly important as the technologies available to urologists are constantly advancing and practicing urologists are finding themselves having to learn procedures outside of their traditional training. In this chapter we discussed simulators specific to cystoscopy, ureteroscopy, transurethral treatments of BPH, percutaneous procedures, laparoscopy, robotics, and open urologic procedures. As the field continues to grow, we expect new and exciting ways to educate trainees, particularly with the use of simulation.
Multiobjective Optimization and Local Merge for Clustering Attributed Graphs

Methods for detecting the community structure in complex networks have mainly focused on network topology, neglecting the rich content information often associated with nodes. In the last few years, the compositional dimension contained in many real-world networks has been recognized fundamental to find network divisions which better reflect group organization. In this paper, we propose a multiobjective genetic framework which integrates the topological and compositional dimensions to uncover community structure in attributed networks. The approach allows to experiment different structural measures to search for densely connected communities, and similarity measures between attributes to obtain high intracommunity feature homogeneity. An efficient and efficacious post-processing local merge procedure enables the generation of high quality solutions, as confirmed by the experimental results on both synthetic and real-world networks, and the comparison with several state-of-the-art methods.
Retrosigmoid Approach for Resection of Large Cystic Vestibular Schwannoma

Objectives This video was aimed to describe the surgical indications, relevant anatomy, and surgical steps of retrosigmoid approach for resection of a large cystic vestibular schwannoma (VS). Design The operative steps are described in a surgical instructional video. Setting The surgery took place at a tertiary skull base referral center. Participant Patient is a 62-year-old man who reported with right sided profound hearing loss with no word recognition, progressive dizziness and tinnitus, excruciating burning pain in the V2 distribution of right trigeminal nerve, wide-based gait, and a right cerebellopontine angle (CPA) cystic VS measuring 3.3 cm. Main Outcome Measures The large cystic VS was resected through retrosigmoid approach. Results The surgery resulted in removal of the large cystic VS with initial delayed facial weakness that completely resolved (House Brackmann grade 1) by 3 month follow-up. The patient had no other postoperative complications and is convalescing well from the procedure. Conclusion Cystic VS presents some unique challenges compared with their solid counterparts. The cystic tumor capsule may be very adherent to the adjacent structures, and distinguishing thin cyst walls from the arachnoid of the CPA, can be quite challenging. The retrosigmoid approach provides adequate surgical exposure for VS tumor resection. The link to the video can be found at: https://youtu.be/sFNvRWG465Q .
Reliability-Aware Fog Resource Provisioning for Deadline-Driven IoT Services

Rapid growth of Internet of Things (IoT) services with different service level agreement (SLA) requirements has called for offloading computing tasks from the resource constrained IoT devices to the remote cloud. The growing number of IoT devices is exacerbating the links between IoT devices and the cloud. Furthermore, many services (e.g., health and disaster response) require fast service response and immediate data analytics, thus posing a great challenge to the remote cloud. Fog computing provides the solution by bringing computing resources to the edge of the network to assume substantial computing tasks. However, the resource failures during service processing should not be overlooked because they can greatly degrade service performance. In our work, we investigate the fog resource provisioning problem for the deadline-driven IoT services to minimize the system cost considering the probability of resource failures. We formulate the problem as an integer linear programming (ILP) model, and then design a Weighted Best Fit Decreasing (WBFD) algorithm with low computational complexity. Simulation results validate that our proposed algorithm performs close to the optimal solutions of ILP.
A comparative injury severity analysis of rural intersection crashes under different lighting conditions in Alabama

This article explores the factors contributing to the injury severity resulting from rural intersection crashes in Alabama under different lighting conditions. Given the occurrence of a crash, sepa...
Distribution of mercury species in the Western Arctic Ocean (U.S. GEOTRACES GN01)

Abstract Mercury (Hg) in the Arctic Ocean is a concern due to unusually high concentrations of monomethylmercury (MMHg) in fish and marine animals. Increased human exposure from consumption of these animals is a significant health concern that is related to Hg contamination in nature. Most Arctic marine Hg research has investigated the amounts, distributions, and cycling in animals, snow, and ice, while few studies have examined the aqueous behavior and fate of Hg in the polar ocean. Here we present the most comprehensive dataset published to date detailing Hg speciation and distribution of elemental Hg (Hg0), dimethylmercury (DMHg), and filtered and particulate total Hg and MMHg in the western Arctic Ocean. This data was obtained as part of the U.S. Arctic GEOTRACES cruise (GN01) in 2015. Many water masses sampled appeared to be enriched with anthropogenic Hg. The Transpolar Drift supplied HgT and Hg0 to the central Arctic Ocean, but not methylated Hg. Gaseous Hg0, but not DMHg, was elevated in surface waters under the ice cover. Monomethylmercury levels, which averaged 0.054 ± 0.050 pM, are lower than other major ocean basins, suggesting ambient MMHg levels in western Arctic Ocean seawater do not by themselves explain anomalously high Hg in Arctic animals.
Homogeneous Metal Salt Solutions for Biomass Upgrading and Other Select Organic Reactions

The growing interest in biomass as a renewable feedstock drives research toward innovative processes and performance-advantaged bioproducts. Homogeneous metal salt solutions are promising media owi...
A Quantum Element Reduced Order Model

A reduced-order model for quantum eigenvalue problems developed previously is revised and combined with the domain decomposition method to construct the quantum element method (QEM). The basic idea of the QEM is to partition a quantum domain structure into several subdomains or elements. Each element is projected onto a functional space using the proper orthogonal decommission. These elements are then combined together to construct the whole domain structure. The proposed QEM has been demonstrated in 2 quantum well structures constructed with several elements. The study illustrates that the QEM is capable of offering accurate prediction of wave functions and quantum eigenenergies with a substantial reduction in the numerical degrees of freedom compared to direct numerical simulation of the Schrodinger equation.
E-121 Single center experience with a novel FDA-approved percutaneous femoral artery closure device (CELT ACD®) in neurovascular procedures

Purpose Celt ACD® (Vasorum Ltd. Dublin, Ireland) is a unique percutaneously applied vascular closure device that achieves hemostasis through the delivery of a stainless steel (316 LVM) plug which is anchored on both sides of the arterial wall. The extendable wings of the implant provide an immediate vascular closure. We studied the safety and efficacy profile of the Celt in our neurodiagnostic and interventional cases. Patients and method After obtaining a local IRB approval, Celt was used in all consecutive neurodiagnostic and interventional cases from 2018 to 2019. Patients presented with or without a systemic thrombolytic agent or a dual antiplatelet therapy. A 5, 6 and 7 F Celt system was available for closure. The 7 F device can be used for a femoral sheath size up to 9 F. Recorded data were analyzed for an immediate failure to close the access site, early or delayed migration of the implant, pain or delayed neuropathy, infection, early or delayed hematomas and other unforeseeable complications at the puncture site. Results Celt was applied in 271 neuro-endovascular procedures in a total of 204 patients (M: F ratio 1.4: 1; age range 24 - 93 years). Majority of subjects (72%) presented either on systemic thrombolytic agents (tPA or Heparin) or were placed on a dual antiplatelet agent prior to the procedure. The closure device was used for a right femoral artery access in 76.4%, left femoral artery in 19.9%, right femoral vein in 1.48% and left femoral vein in 2.2% of the cases. The most common implant used was a 5 F system (55.7%), followed by a 6 F (26.19%) and a 7 F (18.08%) system. Three (1.4%) major complications and 18 (8.8)% minor complications were observed. We encountered in our early learning stage a failed attempted placement of Celt in one venous and one arterial access each (0.98%) that remained asymptomatic. In one of these cases the Celt implant was accidentally deployed without properly attaching to the arterial wall. The device was dislodged into the popliteal artery without any flow restriction and the patient remained asymptomatic. Other adverse events were a complete and symptomatic occlusion of right external iliac artery, 1 patient presented with a delayed peripheral neuropathy. No early or delayed hematomas were observed whenever a proper device placement was achieved. On follow-up angiograms, several months following the placement, Celt implants were found in 18 cases adjacent to the arterial wall within the soft tissue. The extravascular migration remained asymptomatic and has previously been observed with other closure devices and may be related to arterial pulsation. Conclusion Based on our experience Celt is very easy to use and an exceptionally safe and effective percutaneous closure device. Disclosures W. Htun: None. N. Patel: None. R. Rabinovich: None. S. Newman: None. A. Wakhloo: None.
Synthesis of internally alkylated azuliporphyrins

Examples of internally alkylated azuliporphyrins were prepared by MacDonald-type “3 + 1” condensations. 2-Methyl- and 2-ethylazulene reacted with an acetoxymethylpyrrole in the presence of an acid ...
Antitrust in Retrograde: The Consumer Welfare Standard, Socio-Political Goals, and the Future of Enforcement

Part I of this Chapter examines the history of antitrust law to contextualize the current debate regarding the consumer welfare standard. It addresses the numerous legislative history arguments and examines the courts’ experience enforcing the antitrust laws over the last 130 years, tracing the reasoning behind antitrust law’s developments and its adoption of the consumer welfare standard. Part II describes what the consumer welfare standard is and how it operates today, demonstrating its robustness and articulating its many benefits—to the courts, to enforcers, to firms, and to the public at large. Part III turns to the current debate, analyzing the validity and identifying the shortcomings of the arguments neo-Brandeisians proffer in support of abandoning the consumer welfare standard. Part IV concludes. This Chapter does not necessarily reflect the views of the Department of Justice. I would like to thank Judge Douglas H. Ginsburg and Josh Wright for valuable comments and discussion.
Why is ageing associated with lower adoption of new technologies? Evidence from voluntary medical male circumcision and a structural model

Abstract A popular conception is that older people are less likely to adopt new technologies than are younger people. The mechanism underlying this relationship is less well-known. I provide evidence on this question using data from the introduction of voluntary medical male circumcision (VMMC), a new medical technology with substantial health benefits in high HIV prevalence settings. I find limited support for several leading potential mechanisms such as previous investment in older substitute technologies, cohort differences in educational attainment, or various life-cycle changes (i.e. marriage, having ever had sex, coital frequency). I provide a model demonstrating that shorter time horizons and lower consumption values of life mechanically associated with ageing may cause lower VMMC adoption among older males and simulate the adoption-age profile under various parameter assumptions. I discuss implications for policymaking and future research.
Within-Person Associations of Self-Reports of Memory Impairment and Depressive Symptoms in Older Adults: Moderation of Relationships Over Time by Personality.

Objectives The current study examined within-person associations of self-reports of impaired current memory functioning and perceived decline with depressive symptoms in older adults without cognitive impairment, and whether these associations were moderated by individuals' levels of neuroticism, conscientiousness, and extraversion. Methods Samples were drawn from the Einstein Aging Study (EAS), Rush Memory and Aging Project (MAP), Minority Aging Research Study (MARS), Health and Retirement Study (HRS), and National Health and Aging Trends Study (NHATS), with over 8,000 participants (65+ years) included across datasets. In a series of coordinated analyses, multilevel linear models tested within-person relationships over periods of up to 22 years. Results Across HRS and NHATS samples, self-reports of impaired current memory functioning covaried with depressive symptoms over time. This association was moderated by neuroticism, such that the association was stronger for individuals with higher levels of neuroticism. Across all samples, perceived memory decline covaried with depressive symptoms over time. This association was moderated by neuroticism in MAP/MARS, HRS, and NHATS, such that the association was stronger for individuals with higher levels of neuroticism. Discussion Self-reports of impaired current memory functioning and perceived memory decline are important determinants of older adults' psychological well-being. In our results, at times when older adults perceive poorer memory functioning or decline, they also tend to report more depressive symptoms. Further, results from two larger datasets suggest that individuals' level of neuroticism may determine the extent to which self-reports of memory impairment and depressive symptoms covary over time.
The Paycheck Protection Program (PPP) from the Small Business Perspective: Did the PPP Help Alleviate Financial and Economic Constraints? (preprint)

Do business bailouts help alleviate recipient firms’ financial and economic constraints, are effects strongest for the primary targets of the bailouts, and are effects temporary or long-lasting? We address these questions for the Paycheck Protection Program (PPP) small business bailout during COVID-19. We analyze survey responses from small business owners for almost a year from the National Federation of Independent Business (NFIB) and Small Business Administration (SBA) data on PPP loans. Results suggest PPP loans significantly alleviated constraints, primarily for targeted firms – those in the most COVID-19-impacted industries, smaller firms, and firms in lower-income counties – but effects are temporary.
Несколько заметок на полях статьи оппонента: насколько пригодны эти инструменты для оценки возможных нарушений 3 ноября? (Few Reactions on the Opponent’s Article: Are Proposed Instruments Fit to Measure Alleged 11/3 Irregularities?)

Russian Abstract: Ниже приведено несколько заметок и реакций на аргументацию А.Л.Киреева в его статье «География и статистика результатов президентских выборов в США – ключ к пониманию их достоверности». Автор, признавая определенные организационные несовершенства прошедших примерно 3 ноября 2020 выборов в США, настаивает на том, что крупных фальсификаций на них не было. Основой его аргументов является использование аналитических инструментов с помощью которых выявляют серьезные нарушения на выборах в постсоветских странах. Мы представляем свои возражения на эти аргументы и показываем, что приведенные А.Киреевым факты можно интерпретировать совсем иным образом. English Abstract: The present notes contain our reactions to the “Electoral Geography and Statistics as a Key to Understanding the Fairness of US Presidential Elections” article. The author – A.Kireyev supposes some means of electoral geography utilized to detect irregularities in elections in the post-soviet could be successfully applied for the assessment hypothesis on electoral fraud in the US Presidential elections ‘about November 3, 2020’. We guess, that the indicators proposed in the article, are hardly fit for US elections analysis. We put forward examples of alternative interpretations of some basic facts provided by A.Kireyev in his article.
Detection of lymphotoxins in vivo. I. Specific identification of short-lived LT activity in the plasma of various human patients employing rabbit anti-human LT sera in vitro.

Effector molecules termed lymphokines (LK) with a broad spectrum of biologic activities are released by activated human lymphocytes in vitro. One family of LK, the lymphotoxins (LT), have been shown to be cytostatic or cytotoxic for cells in vitro. They have also been proposed to be effectors in tissue destructive cell-mediated immune reactions (CMI) in vitro. However, they have not been shown previously to be present in vivo. We tested fresh plasma from patients with rheumatoid arthritis, multiple sclerosis, and various classes of neoplasia and from recipients of allografted kidneys for LT activity. Patient plasma was cytotoxic for murine L-929 cells in vitro. Employing xenogeneic anti-human LT antisera, we were able to neutralize portions of this toxicity. This LT-like activity in patient plasma was very labile and only detectable in fresh and rapidly handled samples. Low levels of LT activity were detectable in 70 to 100% of the individuals in these patient populations. In contrast, they were completely absent in sera from healthy age-matched controls. While sera from a second type of control group, individuals with tissue destructions of nonimmunologic origin, exhibited some cytotoxic activity in vitro, only sera from one patient was significantly neutralized by anti-LT sera. The types of LT detected and the levels varied from patient group to patient group. These initial studies indicate: (a) LT-like materials exist in vivo, (b) a serum LT inactivation mechanism exists in vivo, and (c) the presence of LT in the serum may represent a new direct measure of ongoing CMI reactivity in vivo.
Discovering Novel Adverse Drug Events Using Natural Language Processing and Mining of the Electronic Health Record

This talk presents an overview of our research in use of medical knowledge, natural language processing, the electronic health record, and statistical methods to automatically discover novel adverse drug events, which are serious problems world-wide.
Aquinas and the Natural Law

Recent decades have seen a shift away from the traditional view that Aquinas's theory of the natural law is meant to supply us with normative guidance grounded in a substantive theory of human nature. In the present essay, I argue that this is a mistake. Expanding on the suggestions of Jean Porter and Ralph McInerny, I defend a derivationist reading of ST I-II, Q. 94, A. 2 according to which Aquinas takes our knowledge of the genuine goods of human life and their proper ordering to one another to be self-evident only to the wise who are able to discern the truth about our God-given human nature. I then show that this reading provides a better account of Aquinas's view than two recent alternatives: John Finnis's brand of inclinationism and Daniel Mark Nelson's virtue-based interpretation.
Is the Concept of the Person Necessary for Human Rights

The concept of the person is widely assumed to be indispensable for making a rights claim. But a survey of the concept’s appearance in legal discourse reveals that the concept is stretched to the breaking point. Personhood stands at the center of debates as diverse as the legal status of embryos and animals to the rights and responsibilities of corporations and nations. This Note analyzes the evidence and argues that personhood is a cluster concept with distinct components: the biological concept of the human being, the notion of a rational agent, and unity of consciousness. This suggests that it is the component concepts—not personhood itself—that are indispensable for grounding our moral and legal intuitions about rights. The component concepts also promote greater systematicity and coherence in legal reasoning. The Note concludes by suggesting some implications of this view for applied legal reasoning.
Effects of competition, success/failure, and sex on intrinsic motivation.

Abstract The purpose of the present investigation was to determine the effect of different types of competition and success/failure on intrinsic motivation of males and females performing on a motor task. Subjects were randomly assigned to one of the following competition conditions: (a) face-to-face competition, (b) competition against a standard of excellence, or (c) a noncompetitive condition (control). In addition, subjects received either success or failure feedback while performing on the pursuit rotor. Results indicated that subjects receiving success exhibited more intrinsic motivation than subjects receiving failure. Subjects also displayed more intrinsic motivation during competition than when not in competition. In addition, the Sex × Competition interaction indicated that males exhibited more intrinsic motivation when competing than when not competing, whereas females displayed no differences between these conditions. Results are discussed in light of previous research by Deci (1975) and Deaux...
Advances in Digital Image Processing for Document Reproduction

The properties of conventional, ordered dot-pattern generation techniques for bi-level halftone representation are examined and compared with the properties of error-diffusion-based, disordered dot-pattern-generation algorithms. The various processing steps necessary for adaptation of the disordered halftone pattern-generation technique to digital image hardcopy reproduction with non-ideal computer-output printing devices are described. It includes procedures for spatial distribution of thresholding errors, suppression of dot-density artifacts and compensation for dot overlap. These procedures represent the core of a Multiple-Error Correction Computation Algorithm called MECCA, the objective of which is to linearize the non-ideal printing process in order to minimize the loss or shift of tonal gradations. Finally, the performance of MECCA is compared with a conventional digital screening technique, and the various reproduction-quality versus computational-complexity trade-offs are discussed.
The interaction between Meloidogyne arenaria and Cylindrocladium parasiticum in runner peanut

Cylindrocladium black rot (CBR), caused by Cylindrocladium parasiticum , and root-knot nematode, Meloidogyne arenaria , both infect and cause damage to the roots of peanut. Greenhouse and microplot experiments were conducted with the runner type peanut genotypes C724-19-15, C724-19-25 and Georgia-02C with different levels of resistance to nematode and CBR to better understand the interactions between the two pathogens. In the greenhouse, inoculation of 500‐3000 eggs per plant of M. arenaria did not affect the level of root rot induced by 1·0 to 5·0 microsclerotia of C. parasiticum per g soil. In microplots, the root rot ratings from Georgia-02C and C724-19-25 were higher in plots infested with M. arenaria (0·4‐2·0 eggs per cm 3 soil) and C. parasiticum than in plots with C. parasiticum alone; however, M. arenaria did not increase the root rot ratings on the nematode resistant C724-19-15. This was inconsistent with results in the greenhouse. Gall indices were not affected by C. parasiticum inoculations in the greenhouse or microplots. In both 2006 and 2007, a significant interaction between C. parasiticum inoculum densities and nematode level was observed on plant mortality. CBR inoculum greatly increased mortality on C724-19-25 and Georgia-02C, but not on C724-1915, in the presence of M. arenaria . The mortality increase was more apparent at lower inoculum levels of both pathogens, but on the nematode-susceptible cultivars plant mortality was more with co-inoculations of the two pathogens than from either alone. Simultaneous inoculation with the two pathogens decreased yield of C724-19-25 and Georgia-02C as C. parasiticum inoculum levels increased, but even the largest inoculum of M. arenaria (2·0 eggs per cm 3 soil) did not decrease yield of C724-19-15.