cssi/SciSciGPT-SciSciNet huggingface dataset:
Immediate autopolymerizing acrylic resin facial prosthesis

C halian’ describes facial disfigurement as an abnormality of the face that sets the individual apart from other members of society. The changes caused by radical surgery are often viewed by patients as the termination of their former life.’ A sudden change in physical appearance, which often follows radical head and neck surgery, may require certain behavior modification. Coincidental to a patient’s acceptance of himself is the initial reactions with his environment. Interactions with hospital staff, family, and friends, if supportive to a patient’s self-esteem, will help motivate the patient toward better recovery and rehabilitation. The fabrication of an immediate postsurgical facial prosthesis assists the patient in interactions with the immediate environment. Likewise, the patient’s friends and family will react in a less alienated and disruptive manner when the postsurgical defects are masked by an immediate facial prosthesis. The need to minimize negative responses to facial disfigurement in the immediate, most sensitive, postsurgical phase is essential for positive self-esteem of the patient and effective rehabilitation.
Shipwrecks and sudden deaths.

In countries where we have good historical population statistics life expectancy has increased with a remarkable 3 months per year, year after year during the past 160 years.1 The main causes of this development must be improvements in social conditions, broadly defined. Only wars and pandemics of deadly infectious diseases have left visible marks on the life expectancy curve. So what is the problem? All is fine; it's fine, it's fine. Except for a few things, which we may have overlooked. The remarkably long-lasting gain in life expectancy is seen in affluent societies. We do not have good data for poorer countries and the continuing increase may not be sustainable, although demographers may be right in concluding that we have not yet seen any sign of a maximum life expectancy. It is hard to believe we will not be caught up with …
Abstract 39: Adrenal ßArrestin1 Raises Serum Aldosterone Levels And Blood Pressure, Both Significant Stroke Risk Factors, In Experimental Rats And Mice

Introduction: It is widely accepted nowadays that elevation of serum levels of aldosterone, a mineralocorticoid hormone with toxic effects in several cardiovascular tissues, including the heart and cerebral blood vessels, can significantly raise stroke risk. The success of mineralocorticoid receptor blockers, such as eplerenone, at preventing stroke attacks attests to this. Aldosterone is normally produced and secreted by the adrenal cortex in response to angiotensin II. We recently reported that adrenal βarrestin1 (βarr1) plays a crucial role in the physiological angiotensin II-stimulated aldosterone production in the adrenal cortex, leading to marked elevation of circulating serum aldosterone levels in vivo (Lymperopoulos A. et al., Proc. Natl. Acad. Sci. USA. 2009;106:5825-5830). Hypothesis: Herein, we examined the potential impact of this adrenal βarr1-dependent aldosterone elevation on stroke risk in experimental animals in vivo. Methods: We used the βarr1 knockout (βarr1KO) mouse model, studying it alongside wild type (WT) control mice, and also adult male Sprague-Dawley rats, in which adrenal βarr1 was overexpressed in vivo via adrenal-targeted adenoviral-mediated βarr1 gene transfer. Serum aldosterone was measured by ELISA and blood pressure via telemetry. Results: Serum aldosterone at 7 days post-in vivo gene delivery was markedly elevated in adrenal βarr1-overexpressing rats (536+50 pg/ml), compared to control rats receiving the green fluorescent protein (GFP) adenoviral transgene (235+40 pg/ml, p Conclusions: Adrenal βarr1 up-regulation can dramatically increase circulating aldosterone levels and systemic blood pressure, thus conferring increased risk for stroke in experimental rodents.
Evaluating Distributional Differences in Income Inequality

Income and wage inequality between gender and other social groups is commonly evaluated by the difference in average income or the decomposition of the total amount of inequality into between-group...
Optimizing Fluctuating Thermal Regime Storage of Developing Megachile rotundata (Hymenoptera: Megachilidae).

The alfalfa leafcutting bee, Megachile rotundata (F.), is the primary pollinator for alfalfa seed production in North America. Under current management practice, developing pupae are incubated at 29–30C until the adults emerge for pollination. If unfavorable spring weather delays peak alfalfa bloom, managers will cool pupae to slow development, which can increase mortality and causes sublethal effects. Previously, we demonstrated that exposure to a fluctuating thermal regime (FTR) increases survival and extends the viable storage period. To determine the optimal conditions for FTR during storage of developing M. rotundata, we examined four variables: temperature of the daily warm pulse, duration of the warm pulse, number of weeks exposed to the FTR treatment, and developmental stage of the bee. Survival was measured by successful eclosion to the adult stage. Under all conditions, exposure to FTR increased survival compared with exposure to a constant 6C. When the temperature of the daily warm pulse was 20–25C from a base temperature of 6C, and the pulse duration was extended to 3 h, survival rates were as high as those observed under standard storage conditions (29C). Under this FTR storage protocol, bee managers can delay emergence for 8 wk without significant decreases in survival. Our findings have substantial economic implications for bee management and alfalfa seed production by increasing the flexibility and efficiency of M. rotundata adult emergence.
An Integrated Approach to Simulation of Pharmaceutical Processes for Solid Drug Manufacture

There are significant economic incentives to transition from batch to continuous processing of pharmaceutical products. However, several challenges must be overcome in order to implement continuous manufacturing systems for solids-based processes. Among these is the need to develop increased understanding of continuous processes and their sensitivity to variability in input materials, processing equipment, and operating conditions. In the current work, integrated flowsheet modeling is used to evaluate a continuous process for tablet production via direct compaction. Simulation of the flowsheet model is used to assess the impact of variability in input material properties as well as process design and operating parameters on product quality. Global sensitivity analysis is also used to identify gaps in the existing process model with the goal of determining specific areas where model improvement can be effected.
The dangerous fruit of Augustine's confessions

Dans un des six tableaux qu'il consacre a la vie de saint Augustin, l'artiste francais Carle Van Loo brosse le portrait du jeune pretre au debut de sa carriere prechant devant une congregation de fideles. Le tableau s'intitule Predication de saint Augustin devant Valere, eveque d'Hippone. A travers son oeuvre, Van Loo propose sa propre vision d'Augustin. Van Loo celebre l'eveque d'Hippone mais en meme temps, il subvertit le message. Il convertit une scene d'instruction religieuse en un pur spectacle. Augustin devient une sorte d'icone qui prend place dans un culte de la personnalite
Perpetuities Against Rules: Law, Ethnography and the Measuring of Lives

The writing of culture (ethno-graphy) that has characterized the modern anthropological endeavor has come under critique for measuring the lives of Others according to its own peculiar normative and temporal logics, and then eliding the fact that it is doing so. The same is true of law, where the writing of human action gets figured in ways that always involve some un-ruly combination of legal fact and norm, and the temporal trajectories that are implicit in them. The effect in both modes of knowledge production is a kind of representative impossibility such that the authority claims made by law and ethnography are always exceeded by the actual lives whose measure they take. In this article, I suggest that it is in its confrontation with the lives and times of inheritance in two contexts – in the famous problems posed in Anglo-American law by the Rule Against Perpetuities, and the irresolution of inheritance disputes in Hopi tribal court – that law is most starkly revealed as a kind of ethnography, a writ...
Homesick at college: A predictive model for first-year first-time students

This study intends to bridge the gap between understanding homesickness as a merely psychological phenomenon and the paucity of literature on homesickness in the field of higher education, the goals of which include: (1) to advance understanding about the experiences of homesickness in the first-year first-time college students; (2) to identify the characteristics of first-year first-time college students who suffer severe homesickness and to examine how they resemble or differ from other students who experience homesickness only in a mild form; (3) to develop an integrative model of predicting first-year first-time college students’ degree of homesickness which will shed light on the implication for improving practices and policies in universities. Three theoretical perspectives are used to explore the dynamic process of homesickness among college students: (1) psychological perspective, including Fisher’s (1989) composite model of homesickness, dual process model of coping with bereavement (DPM) (Stroebe & Schut, 1999), belonging theory (Watt & Badger, 2009); (2) student development perspective, including Tinto’s (1987, 1993) theory of student departure and Pascarella’s (1985) general model for assessing change; (3) social cognitive perspective (Bandura, 1977, 1986, 1991; Torres & Solberg, 2001; Close 2001). A predictive model of homesickness is proposed subsequently by elaborating student development model and incorporating additional factors from psychological and social cognitive perspectives. Data are collected from all the first-year first-time students in fall 2013 cohort at a large public research-intensive university in Midwest. The analytical approach employed in this study includes descriptive statistics, ANOVA tests, factor analysis and structural equation modeling. First, descriptive analysis is used to describe the characteristics of the overall sample. Second,
Hemizona assay: assessment of sperm dysfunction and prediction of in vitro fertilization outcome

Abstract The hemizona assay (HZA) was used in a prospective, blinded study to assess the relationship between tight sperm binding in the HZA and sperm fertilizing ability in in vitro fertilization (IVF). In each controlled assay, the authors compared sperm binding of proven fertile men with that of patients undergoing IVF. Human oocytes stored in a salt solution were used in the study, and binding results were correlated with the fertilization rate of preovulatory oocytes during IVF. Patients with poor fertilization rates in IVF had significantly lower binding than those cases with successful fertilization (7.3 ± 1.4 versus 62.1 ± 10.9, respectively; mean ± standard error, P
Immunological aspects of aging and malnutrition: consequences and intervention with nutritional immunomodulators

As knowledge of molecular and cellular mechanisms of development and aging is elucidated, the need to understand the relationships among tissues, organ systems, health habits, nutrition, physical activity, and environmental factors on successful aging becomes more explicit. Progress in our understanding of how the immune system functions and responds with other factors, such as aging and nutrition, is spawning significant inroads to achieving a successful old age.
Flummoxed by the FLOX

This case discusses the pharmacokinetic interaction between tizanidine and ciprofloxacin. Tizanidine is a cytochrome P450 1A2 substrate and ciprofloxacin is a 1A2 inhibitor.
Unsheltered Homeless Youth Point-in-Time Count and Outreach: Opportunities for University–Community Collaboration (Practice Note)

Unaccompanied homeless youth (< 25 years of age) are the group most likely to be underreported in annual point-in-time (PIT) counts of unsheltered individuals. This practice note reviews the process of a collaborative partnership between a university and community to conduct a successful youth PIT count outreach that more accurately reflected the number of homeless youth. In addition to almost doubling the number of unsheltered homeless youth who were identified between 2013 and 2014, several positive outcomes for students, providers, and faculty resulted through the project's efforts. These outcomes, including increased student exposure and interest in this vulnerable population, are reviewed.
Getting Patients Walking: A Pilot Study of Mobilizing Older Adult Patients via a Nurse-Driven Intervention.

Objectives To develop a system-based intervention including five components that target barriers to nurse-initiated patient ambulation. Design Pilot study of Mobilizing Older adult patients VIa a Nurse-driven intervention (MOVIN). Setting Twenty-six bed general medical unit. Participants Nursing staff (registered nurses and certified nursing assistants) were recruited to participate in focus groups. Measurements Information on frequency and distance patients ambulated and nursing staff documentation of patient ambulation were retrieved from the electronic medical record. Regression discontinuity analysis was used to determine a difference between the preintervention and intervention periods in ambulation occurrence, ambulation distance, and percentage of numeric documentation of ambulation. Thematic analysis was used to analyze focus group interviews. Results A statistically significant increase in number of occurrences (t = 4.18, P = .001) and total distance (t = 2.75, P = .01) and a significantly higher positive slope in percentage of numeric documentation was found during the intervention than before the intervention. Thematic analysis identified three central categories (shifting ownership, feeling supported, making ambulation visible) that describe the effect of MOVIN on nursing staff behaviors and perceptions of the intervention. Conclusion Decreasing loss of independent ambulation in hospitalized older adults requires new and innovative approaches to addressing barriers that prevent nurse-initiated patient ambulation. MOVIN is a promising system-based intervention to promoting patient ambulation and improving outcomes for hospitalized older adults.
Honoring the Experiences of Gay Stepfamilies: An Unnoticed Population

ABSTRACTThis article will acquaint the reader with the experiences of a largely overlooked yet growing subpopulation of stepfamilies: gay stepfamilies. The article presents available data on the prevalence of gay stepfamilies, their identified strengths, their known challenges, and the implications of these family experiences for family counselors who serve this population. The reader will also be provided with directions for future research and study specific to this population.
The chemistry of allergens: VII. The nature of the unidentified allergens of cottonseed

Abstract 1.1. A method for guidance in chemical fractionation procedures and an attempted isolation of unidentified allergens in cottonseed are described. 2.2. Globulin fractions of cottonseed, which retained 2CS allergenic activity after prolonged purification, were prepared. These purified globulin fractions were not completely free from CS-1A, as shown by anaphylactic tests. 3.3. Conclusive evidence of the specificity of the skin response of cottonseed patients to CS-1A and 2CS was shown by direct testing with a series of fractions. Two Type I patients reacted positively when tested with whole cottonseed or unheated globulin preparations but negatively when tested with CS-1A or CS-51R.
EdgeLink™ mmW Mesh Transport experiments in the Berlin 5G-Crosshaul Testbed

This paper presents the performance results for a series of outdoor experiments conducted on a fifth generation (5G) mmW Mesh Transport system to show multiplexing of high throughput fronthaul (FH) and backhaul (BH) traffic over a long-range mmW link with exceedingly low latency. The EdgeLink™ millimeter wave (mmW) system was deployed as part of the European 5G-Crosshaul H2020 5G-PPP project where an outdoor mesh network was setup in Berlin with link distances up to 185 meters. The inclusion of a self-organizing Mesh topology guarantees failure recovery within the system through redundant paths which are managed by a cloud based software defined network (SDN) controller.
Nonionic Ethoxylated Surfactants Induce Adipogenesis in 3T3-L1 Cells

Recent studies have demonstrated that a number of environmental contaminants can act as metabolic disruptors and modulate metabolic function both in vitro and in vivo. 3T3-L1 mouse preadipocytes are commonly utilized to assess perturbations to adipogenesis, providing insight into environmental contaminants that may impact in vivo metabolic health. This study sought to assess whether various alkylphenol ethoxylates and alcohol ethoxylates (APEOs and AEOs, respectively), ubiquitous contaminants used in common household products, could disrupt metabolic health. 3T3-L1 cells were exposed to increasing concentrations of individual ethoxylated surfactants and base hydrophobes, and assessed for triglyceride accumulation (relative to a rosiglitazone-induced maximum response) and preadipocyte proliferation (relative to a differentiated vehicle control). We report herein that nonionic APEOs and AEOs promoted triglyceride accumulation and/or preadipocyte proliferation in 3T3-L1 cells at concentrations from 0.1 to 10 μM. Activity appeared to be an effect of the polyethoxylate chain length, as the alkylphenol/alcohol hydrophobes exhibited minimal or no adipogenic activity. In addition, nonylphenol ethoxylates (NPEO) of various ethoxylate chain lengths exhibited biphasic adipogenic activity, with increasing triglyceride accumulation and preadipocyte proliferation from NPEO (0, average ethoxylate number) through NPEO (4), and then decreasing activities from NPEO (4) through NPEO (20). Our results suggest potential metabolic impacts of these compounds at environmentally relevant concentrations, demonstrating a need to further assess molecular mechanisms and better characterize environmental concentrations of the specific AEOs and APEOs that are inducing the greatest degree of adipogenic activity herein.
Al otro lado del espejo. Obra y ruina

Mediante el estudio de las fotos de obra de los edificios industriales de Albert Kahn y su semejanza con las ruinas clasicas y las ruinas industriales de Detroit, este articulo trata de analizar la relacion entre dos fases que se dan durante el periodo de vida de un edificio. Obra y la ruina se estudian considerandolas dos partes pertenecientes a un unico proceso. El analisis usa ejemplos como los dibujos de Joseph Gandy y Auguste Choisy, o las teorias sobre la ruina de Simmel o Robert Smithson para tratar de definir las convergencias y divergencias entre ambas fases y las caracteristicas del proceso global en el que se encuadran. Partiendo de este analisis, se plantean posibles metodologias operativas en las ruinas industriales que se alejen tanto de la estricta conservacion patrimonial como del actual estado de abandono en el que se encuentran, y equidistantes entre el monumento y el desecho. Se trata de buscar modos de operacion en estos nuevos ambientes antropocenicos, ejemplarizados por las ciudades industriales de “Rust Belt” norteamericano, que sean capaces de establecer un nuevo equilibrio entre agentes humanos y no humanos y entre sistemas tecnicos, culturales y biologicos.
Relationships between IgA and the liver

During the past 10–15 years a great deal of evidence has shown that the liver is very much involved in the secretory IgA system. Much of our understanding of the details of the synthesis, cell-surface expression, and intra-cellular migration of secretory component (the polymeric immunoglobulin receptor) has come from studies in the rodent liver. Also, very remarkable species differences in the clearance of IgA from plasma have been observed: whereas certain animals (rats, mice, rabbits) efficiently clear circulating IgA by a secretory-component mediated, vesicular transport across hepatocytes, several other species (including man) lack this transport pathway. On the other hand, the IgA1 subclass in man might bind to and be internalized or transported by the asialoglycoprotein receptor on hepatocytes. The major biological functions ascribed to the secretion of IgA into bile are enhancement of immunological defense of the biliary and upper intestinal tracts and clearance of harmful antigens from the circulation as IgA-antigen complexes. The true importance of these proposed activities, however, deserve careful investigation. Abnormalities in the metabolism of IgA have been described in many liver diseases, most notably alcoholic liver disease, in which characteristic deposits of IgA1 are common along hepatic sinusoids and, to a certain extent, in the renal mesangium.
High titer anti-HIV antibody reactivity associated with a paraprotein spike in a homosexual male with AIDS related complex.

We observed a human immunodeficiency virus (HIV)-infected homosexual male with AIDS related complex (ARC) who had a serum globulin level of 80 g/L. Serum protein electrophoresis revealed a gamma globulin fraction of 40 g/L, of which 50% (20 g/L) was contained within a paraprotein spike, comprised predominantly of IgG kappa. This patient also had high titer anti-HIV antibodies in his serum, which were Western blot reactive at a final dilution of 1:500,000, and recognized gp120env, p66pol, p55gag, p53pol, p41gag, and p24gag. Because paraproteins in the past have been shown to be directed against specific antigens, we purified this patient9s paraprotein using a modified high performance liquid chromatography (HPLC)-hydroxylapatite procedure and tested the purified paraprotein for anti-HIV antibody activity. The purified paraprotein retained anti-HIV antibody activity to a final dilution of 1:100,000, and recognized p66pol, p55gag, p53pol, p41gag, and p24gag. The recognition of both “gag” and “pol” gene products suggested that the purified paraprotein might not be monoclonal in origin. Sodium dodecyl sulfate-polyacrylamide gel electrophoresis (SDS-PAGE) demonstrated that the purified paraprotein contained at least two immunoglobulin light chain species (Mol wt 30 to 33 Kd). Affinity chromatography of the purified paraprotein using a p24- Sepharose 4B matrix separated the “gag” and “pol” antibody activities. Immunoglobulin gene rearrangement analysis of a bone marrow aspirate (which contained 15% plasma cells) failed to reveal a clonal population of immunoglobulin producing cells. We conclude that this patient9s paraprotein accounted for most of the anti-HIV activity present in whole serum, and that this paraprotein was not monoclonal in origin.
Effects of stereotypic video game portrayals on implicit and explicit attitudes

Past research has demonstrated the negative effects of media stereotypes on implicit and explicit attitudes across various forms of media. Because video games are a relatively new form of media, there is almost no research on the influence of video game stereotypes on people’s attitudes. The main goal of this study was to test the effects of negative video game stereotypes on implicit and explicit attitudes. The results indicated that negative video game stereotypes are associated with negative implicit attitudes but not negative explicit attitudes. Other results revealed influences of overall media stereotypes, sources of information about groups, direct contact with the stereotyped group, peers’ negative attitudes towards the stereotyped group, patriotism, and past negative explicit attitudes on current implicit and explicit attitudes. Implications of media stereotypes, especially in video game are discussed, along with suggestions for future research. vi
Phase transformations in the W–Cr system at the nanoscale

Abstract In order to enhance the thermal stability of nanomaterials, it is important to understand phase transformations at the nanoscale in high detail. In this study, the phase transformations occurring in the nanocrystalline W–Cr system were investigated using nanometallic multilayers to shift the kinetics of nucleation and to increase the diffusivities of W and Cr. The initial metastable state of the multilayers was tailored to favor the formation of solutions rich in W. In addition, the higher diffusivities in the system made it possible to observe the nucleation of the W3Cr intermetallic at 1000 °C, a temperature lower than that reported in previous studies. In this manuscript, the use of nanometallic multilayers is proposed as an approach to modify the thermal evolution of a nanocrystalline systems and study phase transformations at the nanoscale.
Exceptional points and spectral singularities in active epsilon-near-zero plasmonic waveguides

The intriguing physics of exceptional points (EPs) and spectral singularities in open (non-Hermitian) active photonic systems has recently sparked increased interest among the research community. These spectral degeneracies have been obtained in asymmetric active and passive photonic configurations but their demonstration with symmetric active plasmonic structures still remains elusive. In this paper, we present a nanoscale active plasmonic waveguide system consisting of an array of periodic slits that can exhibit exceptional points and spectral singularities leading to several functionalities. The proposed symmetric active system operates near its cutoff wavelength and behaves as an effective epsilon-near-zero (ENZ) medium. We demonstrate the formation of an EP that is accessed with very low gain coefficient values, a unique feature of the proposed nanoscale symmetric plasmonic configuration. Reflectionless ENZ transmission and perfect loss compensation are realized at the EP which coincides with the effective ENZ resonance wavelength of the proposed array of active plasmonic waveguides. When we further increase the gain coefficient of the dielectric material loaded in the slits, a spectral singularity occurs at the ENZ resonance leading to superscattering (lasing) response at both forward and backward directions. These interesting effects are achieved by materials characterized by very small gain coefficients with practical values and at subwavelength scales due to the strong and homogeneous field enhancement inside the active slits at the ENZ resonance leading to enhanced light-matter interaction. We theoretically analyze the obtained EP, as well as the divergent spectral singularity, using a transmission line model, and investigate the addition of a second incident wave and nonlinearities in the response of the proposed active ENZ plasmonic system. Our findings provide a route towards interesting nanophotonic applications, such as reflectionless active ENZ media, unidirectional coherent perfect absorbers, nanolasers, and strong optical bistability and all-optical switching nanodevices.
Development of the Navy's Next-Generation Nonhydrostatic Modeling System

Abstract : The main objective is to continue development of the next generation model, the Spectral Element (SE) model, built on the Element Based Galerkin (EBG) method and evaluate simulations in both two- (2D) and three dimensions (3D). The primary focus is on completing the set of the basic necessary physical parameterizations, adding the ability to use initial boundary conditions from another global model, and reading the climatological database to provide required surface characteristics. The overarching objective is to perform a global weather forecast using real data.
Management of Frontal Sinus Cerebrospinal Fluid Leaks

Frontal sinus cerebrospinal fluid (CSF) leaks are technically challenging to repair, and there are a number of important considerations in evaluation and surgical management. The superior and lateral extents of the frontal recess are difficult to reach endoscopically, while the inferior and posterior portions of the frontal recess are challenging to reach from an external approach. In some cases, a combined approach may be warranted. An important guiding principle in repair is maintenance of frontal sinus patency, as an established outflow tract is necessary to prevent the formation of synechiae and mucoceles. In the following chapter, the anatomy and categorization of frontal sinus CSF leaks are discussed. Etiologies, diagnosis, and surgical approach for frontal sinus CSF leak are reviewed in detail.
Boundary-polarized subsonic Rayleigh waves under conditions of semi-simple Stroh degeneracy

We undertake a study of subsonic free surface (Rayleigh) waves in linear elastic half-spaces of general anisotropy when the wave polarization vector lies in the half-space boundary, if and when the...
Management of two major postoperative bleeding complications after mandible reconstruction with fibula free flap in a patient under chronic warfarin treatment.

AbstractWe present a case of two separated life-threatening postoperative bleeding complications after mandible cancer resection and microsurgical fibula flap in a patient under permanent warfarin ...
Financial impact of post-transplant complications among children undergoing allogeneic hematopoietic cell transplantation.

Complications following allogeneic hematopoietic cell transplantation (alloHCT) continue to be a significant challenge that often result in significant morbidity/mortality and increased healthcare utilization and cost. In this study, we analyzed the impact of post-alloHCT complications on healthcare utilization and cost during first year post-transplant. We analyzed data on 240 pediatric patients. Complications analyzed included kidney injury, liver injury, lung injury, viral infections, bacterial infections, fungal infections, and acute graft-versus-host disease (GVHD). Patients were divided into three groups based on the number of complications (0–1, 2–3, and >3). Cost was estimated from charges recorded in the Pediatric Health Information System database and hospital accounting records. Patients with >3 complications had higher healthcare utilization and cost, primarily driven by inpatient hospitalization and intensive care unit admissions. Multivariable analysis of risk factors identified bacteremia ($90,166, SE = 26,636, p < 0.001), lung injury ($108,529, SE = 28,196, p < 0.001), liver injury ($90,805, SE = 28,660, p = 0.002), and grade II–IV aGVHD ($137,866, SE = 28,472, p < 0.001) as associated with significantly increased cost. Our study highlights the significant impact complications have on the overall cost of alloHCT. The identification that complications associated with high morbidity (aGVHD, pulmonary disease) are also associated with the highest financial burden emphasizes the need for future research in these areas to expand management options and improve outcomes for our patients.
Fund Flow and Managerial Skill: Evidence from Exchange-Traded Funds (ETFs)

New money flow is known as the measure of skill in mutual funds. We investigate the flow-performance relationship in the laboratory of passive Exchange-Traded Funds (ETFs) and find a positive and significant relationship in the absence of the managerial skill. We further show that active ETFs exhibit greater persistence and more pronounced results. Exploring the effect of daily flow shocks on ETF holdings, we disentangle non-fundamental demand from information-based demand. Our results suggest that "price pressure” can fully explain the positive flow-performance relation with passive ETFs, while it only explains half of the same phenomena with active funds. Consequently, even though “smart money” exists, flow may not be a pure proxy for skill.
BIOLOGICAL SCIENCES: Genetics

ABSTRACT Angelman syndrome (AS) is a severe neurodevelopmental disorder caused by the loss of function from the maternal allele of UBE3A, a gene encoding an E3 ubiquitin ligase. UBE3A is only expressed from the maternally-inherited allele in mature human neurons due to tissue-specific genomic imprinting. Imprinted expression of UBE3A is restricted to neurons by expression of UBE3A antisense transcript (UBE3A-ATS) from the paternally-inherited allele, which silences the paternal allele of UBE3A in cis. However, the mechanism restricting UBE3A-ATS expression and UBE3A imprinting to neurons is not understood. We used CRISPR/Cas9-mediated genome editing to functionally define a bipartite boundary element critical for neuron-specific expression of UBE3A-ATS in humans. Removal of this element led to upregulation of UBE3A-ATS without repressing paternal UBE3A. However, increasing expression of UBE3A-ATS in the absence of the boundary element resulted in full repression of paternal UBE3A, demonstrating that UBE3A imprinting requires both the loss of function from the boundary element as well as upregulation of UBE3A-ATS. These results suggest that manipulation of the competition between UBE3A-ATS and UBE3A may provide a potential therapeutic approach for AS. SIGNIFICANCE STATEMENT Angelman syndrome is a neurodevelopmental disorder caused by loss of function from the maternal allele of UBE3A, an imprinted gene. The paternal allele of UBE3A is silenced by a long, non-coding antisense transcript in mature neurons. We have identified a boundary element that stops the transcription of the antisense transcript in human pluripotent stem cells, and thus restricts UBE3A imprinted expression to neurons. We further determined that UBE3A imprinting requires both the loss of the boundary function and sufficient expression of the antisense transcript to silence paternal UBE3A. These findings provide essential details about the mechanisms of UBE3A imprinting that may suggest additional therapeutic approaches for Angelman syndrome.
A Non-Volatile Optical Memory in Silicon Photonics

We demonstrate a non-volatile optical memory element integrated in silicon photonics for low-power reconfigurable photonic circuits and neural networks. Stable transmission states are set by manipulating ferroelectric domains in BaTiO 3 films embedded in photonic waveguides.
Intergradation between discrete lineages of Tevnia jerichonana, a deep-sea hydrothermal vent tubeworm

Abstract We describe a broad zone of intergradation between genetically differentiated, northern and southern lineages of the hydrothermal vent tubeworm, Tevnia jerichonana . DNA sequences from four genes, nuclear HSP and ATPsα and mitochondrial COI and Cytb were examined in samples from eastern Pacific vent localities between 13°N and 38°S latitude. Allelic frequencies at these loci exhibited concordant latitudinal clines, and genetic differentiation (pairwise Φ ST 's) increased with geographical distances between sample localities. Though this pattern of differentiation suggested isolation-by-distance (IBD), it appeared to result from hierarchical population structure. Genotypic assignment tests identified two population clusters comprised of samples from the northern East Pacific Rise (NEPR: 9–13°N) and an extension of the Pacific-Antarctic Ridge (PAR: 31–32°S) with a zone of intergradation along the southern East Pacific Rise (SEPR: 7–17°S). The overall degrees of DNA sequence divergence between the NEPR and PAR populations were slight and not indicative of lengthy isolation. Bayesian assignment methods suggested that the SEPR populations constitute intergrades that connect the NEPR and PAR populations. Though it typically is difficult to distinguish between primary and secondary intergradation, our results were consistent with parallel studies of vent-restricted species that suggest a high degree of demographic instability along the superfast-spreading SEPR axis. Frequent local extinctions and immigration from NEPR and PAR refugia probably shaped the observed pattern of intergradation.
SU-C-304-07: Are Small Field Detector Correction Factors Strongly Dependent On Machine-Specific Characteristics?

Purpose: The current small field dosimetry formalism utilizes quality correction factors to compensate for the difference in detector response relative to dose deposited in water. The correction factors are defined on a machine-specific basis for each beam quality and detector combination. Some research has suggested that the correction factors may only be weakly dependent on machine-to-machine variations, allowing for determinations of class-specific correction factors for various accelerator models. This research examines the differences in small field correction factors for three detectors across two Varian Truebeam accelerators to determine the correction factor dependence on machine-specific characteristics. Methods: Output factors were measured on two Varian Truebeam accelerators for equivalently tuned 6 MV and 6 FFF beams. Measurements were obtained using a commercial plastic scintillation detector (PSD), two ion chambers, and a diode detector. Measurements were made at a depth of 10 cm with an SSD of 100 cm for jaw-defined field sizes ranging from 3×3 cm{sup 2} to 0.6×0.6 cm{sup 2}, normalized to values at 5×5cm{sup 2}. Correction factors for each field on each machine were calculated as the ratio of the detector response to the PSD response. Percent change of correction factors for the chambers are presented relative to the primarymore » machine. Results: The Exradin A26 demonstrates a difference of 9% for 6×6mm{sup 2} fields in both the 6FFF and 6MV beams. The A16 chamber demonstrates a 5%, and 3% difference in 6FFF and 6MV fields at the same field size respectively. The Edge diode exhibits less than 1.5% difference across both evaluated energies. Field sizes larger than 1.4×1.4cm2 demonstrated less than 1% difference for all detectors. Conclusion: Preliminary results suggest that class-specific correction may not be appropriate for micro-ionization chamber. For diode systems, the correction factor was substantially similar and may be useful for class-specific reference conditions.« less
Comparative outcomes of transvenous extraction of sprint fidelis and riata defibrillator leads: a single center experience

Comparison of Extraction of Recalled Defibrillator Leads Introduction The FDA has issued class I advisories for Medtronic Sprint Fidelis® and St. Jude Medical RiataTM ICD lead families. Transvenous RiataTM ICD lead extraction is typically considered higher risk than Fidelis® extraction, based on longer duration from implant, presence of externalized conductors and lack of silicone backfill in the SVC and RV coils. However, published data comparing procedural outcomes between these leads are limited. Methods Records were reviewed for all patients undergoing transvenous extraction of Sprint Fidelis® or RiataTM ICD leads at the Vanderbilt Heart and Vascular Institute from July 2006 to April 2013 to ascertain indication for extraction, procedural details, complications, and 30-day mortality. Results There were significant differences between those undergoing extraction of a Sprint Fidelis® (n = 145) or RiataTM lead (n = 47). In the RiataTM group, device-related endocarditis was a more common indication for extraction, the mean duration of implant was longer, and larger excimer laser sheaths were required. Lead malfunction was a more common indication in the Fidelis® group. There were no statistically significant differences in median procedure duration, procedural success (97.9% vs 95.7%, P = 0.41), median length of hospital stay (1 day vs 1 day, P = 0.23), procedural complication rate (5.5% vs 10.6%, P = 0.23) or 30-day mortality (2.1% vs 2.1%, P = 0.98). Analyses excluding patients with device infection revealed similar results. Conclusion Despite differences in baseline characteristics, this study indicates that Medtronic Sprint Fidelis® and St. Jude RiataTM ICD leads have similar procedural outcomes with transvenous lead extraction.
Robustness of Luenberger function observer to great inertia system

The contradiction of speediness and stability is a difficult problem in face of control theory study and control system design at all times. The paper takes time-variable and great-inertia controlled object and its algebra equivalence system as example open out and explain inherence relation produced by character of time-variable to control index. The sufficiency condition of robust Luenberger function observer comes into existence presented by mathematical analysis. And engineering application method solving the contradiction of speediness and stability has proposed. The practicability and the validity of the design method have been proved by effect of engineering practice in boiler steam temperature control system of thermal power plant.
Noiseless database privacy

Differential Privacy (DP) has emerged as a formal, flexible framework for privacy protection, with a guarantee that is agnostic to auxiliary information and that admits simple rules for composition. Benefits notwithstanding, a major drawback of DP is that it provides noisy responses to queries, making it unsuitable for many applications. We propose a new notion called Noiseless Privacy that provides exact answers to queries, without adding any noise whatsoever. While the form of our guarantee is similar to DP, where the privacy comes from is very different, based on statistical assumptions on the data and on restrictions to the auxiliary information available to the adversary. We present a first set of results for Noiseless Privacy of arbitrary Boolean-function queries and of linear Real-function queries, when data are drawn independently, from nearly-uniform and Gaussian distributions respectively. We also derive simple rules for composition under models of dynamically changing data.
A Parallel Framework for Explicit FEM

As a part of an ongoing effort to develop a "standard library" for scientific and engineering parallel applications, we have developed a preliminary finite element framework. This framework allows an application scientist interested in modeling structural properties of materials, including dynamic behavior such as crack propagation, to develop codes that embody their modeling techniques without having to pay attention to the parallelization process. The resultant code modularly separates parallel implementation techniques from numerical algorithms. As the framework builds upon an object-based load balancing framework, it allows the resultant applications to automatically adapt to load imbalances resulting from the application or the environment (e.g. timeshared clusters). This paper presents results from the first version of the framework, and demonstrates results on a crack propagation application.
Sustained salutary effects of oral controlled-release nitroglycerin on ventricular function in congestive heart failure.

The hemodynamic effects of a controlled-release preparation of original nitroglycerin (ONTG), 6.5 mg to 19.5 mg, were determined during a four hour period in 10 patients with left ventricular failure. After ONTG ingestion left ventricular filling pressure (LVFP) diminished in 20 min (23 to 17 mm Hg, p 0.05) occurred in systolic blood pressure, heart rate, cardiac index (CI) and peripheral vascular resistance (PVR). However, two subgroups were identified relative to ONTG hemodynamic response. In the four patients in whom LVFP declined but remained substantially elevated (29 to 23 mm Hg, p 0.05) without alteration of PVR (1799, p > 0.05). This investigation provides objective evidence of the salutary hemodynamic effects of ONTG and confirms adequate gastrointestinal absorption with attainment of pharmacologically active blood levels. Moreover, oral sustained-release nitroglycerin is shown to possess long-acting peripheral vasodilator actions of considerable value in the treatment of congestive heart failure.
When one whale matters

North Atlantic right whales once faced extinction and are still under threat today. But the population decline could be halted if the lives of just a few females were spared each year.
Heparin bolus therapy during cardiac catheterization

Abstract Anticoagulation with heparin has been used in cardiac catheterization since the development of the technique. While early reports suggested that heparin use lowered complications, particularly those associated with thromboembolic events, 1–6 recent surveys indicate that anticoagulation for standard femoral-approach, left-sided heart catheterization with coronary arteriography has minimal impact on complications. 7–9 However, many laboratories and operators still routinely use varying doses of heparin for cardiac catheterization procedures. Little data address appropriate dosages of heparin or how indexes of anticoagulant effect measurement are altered by the use of heparin during cardiac catheterization. The aims of our study were to determine how effective intravenous heparin is in achieving therapeutic anticoagulation during cardiac catheterization, to examine the effect of various doses of heparin on prothrombin time and partial thromboplastin time and to determine the duration of effective anticoagulation after receiving a specific dose of heparin.
Decreasing inelasticity with energy in pp collisions

The energy dependence of inelasticity in the multiparticle production of high-energy hadronic interactions is studied. The similarity between multiparticle productions in pp (pp) and e+e- collisions leads to a complete picture of a universal hadronization process. Within this framework, the data of charged multiplicity at various collider energies are used to infer average inelasticity. The result shows that inelasticity in pp collisions decreases with increasing energy in the range of square root (s)=5-900GeV. Consequences of the extrapolation of such a decreasing inelasticity to energies 1014-1018 eV as well as other model predictions in a series of cosmic ray experiments are also addressed.
Computer simulation of replacement sequences in copper

Abstract Results of computer simulations of , , and replacement sequences in copper are presented, including displacement thresholds, focusing energies, energy losses per replacement, and replacement sequence lengths. These parameters are tabulated for six interatomic potentials and shown to vary in a systematic way with potential stiffness and range. Comparisons of results from calculations made with ADDES, a quasi-dynamical code, and COMENT, a dynamical code, show excellent agreement, demonstrating that the former can be calibrated and used satisfactorily in the analysis of low energy displacement cascades. Upper limits on , , and replacement sequences were found to be ∼10, ∼30, and ∼14 replacements, respectively.
The efficacy and safety of combined trabeculectomy, cataract extraction, and intraocular lens implantation

Abstract The safety and efficacy of combined trabeculectomy, extracapsular cataract extraction (ECCE), and posterior chamber intraocular lens (PC IOL) implantation were evaluated by retrospectively analyzing 108 consecutive operations. Postoperatively, 89% of eyes achieved 20/40 or better visual acuity when preoperative macular and optic nerve diseases were excluded. Mean follow-up was 16.8 months. Intraocular pressure (IOP) control (≤21 mmHg) was achieved in 92% of eyes; 57% required no medications. Capsulotomy (20%) and transient hyphema (15%) occurred significantly more often ( P
Malignant neoplasms associated with orthopedic implant materials in rats

The carcinogenic potential of 22 orthopedic prosthetic materials was studied by implantation in bone in Sprague-Dawley rats and evaluated by complete autopsy examination performed at the time of death or at the end of the 30 month experimental period. When the number of malignancies in these rats was compared with control and sham-operated animals, a small increase in sarcomata was observed in animals bearing metal alloy implants containing high contents of cobalt, chromium, or nickel. An increased incidence of lymphomata with bone involvement was also observed in rats bearing metal implants when compared with control and sham-operated animals.