cssi/SciSciGPT-SciSciNet huggingface dataset:
Models for Scripture

In 1974 the American Roman Catholic theologian Avery Dulles published an instructive and successful book called Models of the Church, the heart of which considers the church as institution, as mystical communion, as sacrament, as herald, and as servant. It includes a chapter on ‘The church and revelation’, later expanded as a further book called Models of Revelation; but at that point difficulties surely arise. The notion of models as Dulles applies it to the church enables him to take account of the fact that the church is a concrete objective reality, yet one whose nature is complex and difficult to encapsulate. Images which emerge from Bible and tradition, such as the ones Dulles studies, can be applied with a degree of analytical rigour to the church, with illuminating results. Some of these images may be better described as metaphors. They take actual entities such as a herald and use them to cast light on the nature of the church by analogy; they are less systematically developed than models and are more consistently capable of operating at other levels as well as the intellectual (though in theology, at least, models also commonly carry strong emotional associations and thus may profoundly influence attitudes as well as shape conceptual thinking). Some of the images are models in a stricter meaning of the word; they do not in themselves exist in the same sense as the church does, but as constructs they enable us to grasp aspects of the significance of the church conceptually.
Dynamics of two-component biochemical systems in interacting cells; Synchronization and desynchronization of oscillations and multiple steady states

Systems of interacting cells containing a metabolic pathway with an autocatalytic reaction are investigated. The individual cells are considered to be identical and are described by differential equations proposed for the description of glycolytic oscillations. The coupling is realized by exchange of metabolites across the cell membranes. No constraints are introduced concerning the number of interacting systems, that is, the analysis applies also to populations with a high number of cells. Two versions of the model are considered where either the product or the substrate of the autocatalytic reaction represents the coupling metabolite (Model I and II, respectively). Model I exhibits a unique steady state while model II shows multistationary behaviour where the number of steady states increases strongly with the number of cells. The characteristic polynomials used for a local stability analysis are factorized into polynomials of lower degrees. From the various factors different Hopf bifurcations may result in leading for model I, either to asynchronous oscillations with regular phase shifts or to synchronous oscillations of the cells depending on the strength of the coupling and on the cell density. The multitude of steady states obtained for model II may be grouped into one class of states which are always unstable and another class of states which may undergo bifurcations leading to synchronous oscillations within subgroups of cells. From these bifurcations numerous different oscillatory regimes may emerge. Leaving the near neighbourhood of the boundary of stability, secondary bifurcations of the limit cycles occur in both models. By symmetry breaking the resulting oscillations for the individual cells lose their regular phase shifts. These complex dynamic phenomena are studied in more detail for a low number of interacting cells. The theoretical results are discussed in the light of recent experimental data on the synchronization of oscillations in populations of yeast cells.
Beauty as control in the new Saigon: Eviction, new urban zones, and atomized dissent in a Southeast Asian city

The eviction of residents to make way for a “new urban zone” in Ho Chi Minh City, Vietnam, is legitimized by notions of building a beautiful, breathable, and orderly city. Although angry about their unfair treatment in the eviction process, residents ultimately support this discourse of beauty. They challenge eviction through individual squabbles over compensation rates, land measurements, and resettlement sites. In the process, dissent becomes atomized and residents reproduce a mode of valuing land based primarily on monetary value. In this context, notions of beauty, despite having counterhegemonic potential, reproduce rather than challenge core ideals legitimizing the project.
"Assistencialism" and the Politics of High-Stakes Testing.

In this article I argue that the current high-stakes testing accountability model is an assistencialist model, derived from deficit thinking paradigms. Such models, like the No Child Left Behind Act, sanction low performance with serious consequences for students and educators. Drawing from Freire, I propose an anti-assistencialist accountability model based on local community culture and needs that would include critical, problem-posing education, dialogue as a means toward raising social consciousness, and appropriate assessments according to local community needs. I further argue that such an accountability model can be implemented through cultural immersion programs that include three levels of immersion, (1) classroom culture, (2) local community culture, and (3) trans/cultural, or transnational exposure.
Sleep Consolidation of Interfering Auditory Memories in Starlings

Memory consolidation has been described as a process to strengthen newly formed memories and to stabilize them against interference from similar learning experiences. Sleep facilitates memory consolidation in humans, improving memory performance and protecting against interference encountered after sleep. The European starling, a songbird, has also manifested sleep-dependent memory consolidation when trained on an auditory-classification task. Here, we examined how memory for two similar classification tasks is consolidated across waking and sleep in starlings. We demonstrated for the first time that the learning of each classification reliably interferes with the retention of the other classification across waking retention but that sleep enhances and stabilizes the memory of both classifications even after performance is impaired by interference. These observations demonstrate that sleep consolidation enhances retention of interfering experiences, facilitating opportunistic daytime learning and the subs...
Predictive correlates of treatment program completion in a sample of male alcoholics.

This study assessed the effectiveness of selected demographic and psychological variables in distinguishing between those male alcoholics who completed an 8-week inpatient treatment program at a Veterans Administration facility and those who left the program prematurely. Employing a stepwise multiple linear regression procedure resulted in nine variables of sufficient predictability to account for 27% of the variability in the criterion of program completion. Further application of the derived equation resulted in correct classification of 78% of the cases. This represented a 7% improvement over and above knowledge of the observed Stay-Split ratio. These findings were discussed in the context of a multidimensional conceptualization of alcoholism.
Autoregulatory and paracrine control of synaptic and behavioral plasticity by octopaminergic signaling.

Adrenergic signaling has important roles in synaptic plasticity and metaplasticity. However, the underlying mechanisms of these functions remain poorly understood. We investigated the role of octopamine, the invertebrate counterpart of adrenaline and noradrenaline, in synaptic and behavioral plasticity in Drosophila. We found that an increase in locomotor speed induced by food deprivation was accompanied by an activity- and octopamine-dependent extension of octopaminergic arbors and that the formation and maintenance of these arbors required electrical activity. Growth of octopaminergic arbors was controlled by a cAMP- and CREB-dependent positive-feedback mechanism that required Octb2R octopamine autoreceptors. Notably, this autoregulation was necessary for the locomotor response. In addition, octopamine neurons regulated the expansion of excitatory glutamatergic neuromuscular arbors through Octb2Rs on glutamatergic motor neurons. Our results provide a mechanism for global regulation of excitatory synapses, presumably to maintain synaptic and behavioral plasticity in a dynamic range.
Conjuring Medical Science: The 1986 Referendum on AIDS/HIV Policy in California

Medical science occupies a peculiar status in American life. On the one hand, people often view medical science as a privileged and authoritative body of knowledge that transcends other kinds of knowledge. On the other handy medical–scientific authority can be easily conjured from the popular symbols of science, e.g., credentials, technical terms, and white lab coats. This problem can be converted into an anthropological question of meanings and symbols, based on Geertz's interpretive anthropology and Baudrillard' s sociology of hyperreality. This article uses these frameworks to explore the cultural construction of medical-scientific authority in the case of a 1986 referendum on AIDS/HIV policy in California. The interpretation of that construction raises some difficult problems concerning anthropology's treatment of medical science. [AIDS, HIV, cultural construction of science, anthropology of science, hermeneutics of science]
Cellular Factors Binding to a Novel cis-Acting Element Mediate Steroid Hormone Responsiveness of Mouse Mammary Tumor Virus Promoter

Steroid hormone receptors regulate mouse mammary tumor virus (MMTV) gene expression by binding to hormone response DNA elements present in the long terminal repeat. Tissue-specific expression of MMTV is unlikely to be regulated by steroid hormone-receptor complex alone, and mammary cell-specific factors might play a role in the hormone-induced transcriptional activation. In this report we have investigated the function of a novel cis-acting element designated Kil (-204 to -188) which is located adjacent to the distal glucocorticoid response element, in steroid hormone-induced transcription of MMTV. Electrophoretic mobility shift assays indicate that cellular factors bind to the Kil element, and dexamethasone stimulation results in alterations in the binding pattern of proteins in this region. By transient transfection assays using wild type and deletion mutants of the Kil element, we show that this novel cis-acting element is necessary for hormone-induced transcription of MMTV and functions in mammary tumor cells but not in NIH/3T3 cells. Mutagenesis of the Kil sequence suggests that the entire Kil element functioning as one unit is necessary for hormone-induced transcription of MMTV. When placed in the context of heterologous promoters, neither Kil element nor glucocorticoid response element is able to induce significant hormone-induced transcription of MMTV. The presence of both the DNA elements in tandem results in optimal induction of transcription in the presence of steroid hormones. Our results also indicate that the Kil element functions in human breast carcinoma cell lines such as T47D and MCF-7. These results suggest that Kil element in combination with distal glucocorticoid response element functions as a mammary cell-specific enhancer to regulate MMTV transcription.
Exponential decay kinetics in downhill protein folding

The observation of single-exponential kinetic phases in early stages of protein folding is often interpreted as evidence that these phases are rate limited by significant energy or entropy barriers. However, although the existence of large barriers reliably implies exponential kinetics, the reverse is not necessarily true. A simple model for the hydrophobic collapse of a chain molecule demonstrates that a barrierless or "downhill" diffusional relaxation can give rise to kinetics that are practically indistinguishable from a pure exponential. Within this model, even a highly nonlinear experimental probe such as resonance energy transfer (Forster transfer) could exhibit a large amplitude decay (greater than 90% in fluorescence) that deviates from a simple exponential by less than 0.5%. Only a detailed analysis of the dynamics is likely to reveal that a free energy barrier is absent.
Acquisition of /s/-clusters in Spanish-English bilingual children with phonological disorders

This study investigated the development of English two-member onset #sC clusters in Spanish-English bilingual children with phonological disorders. Data from 30 children were analysed in terms of correct and incorrect productions, implicational relationships, and possible groupings according to the sonority index of the second member of the cluster. While a great deal of variability occurred both within and across children, a number of general findings did occur. Sonority sequencing was found to be relevant in accurate renditions. Also justifiable was the binary grouping of /s/+[-continuant] vs /s/+[+continuant]. With regard to reduction patterns, the predictions of factorial typology were found to be useful.
Movement, Home Range, and Site Fidelity of Bluegills in a Great Plains Lake

Abstract Little is known about the distribution, movement, and home ranges of bluegills Lepomis macrochirus in lentic environments. Therefore, the objectives of this study were to evaluate the seasonal and diel differences in movement rates, site fidelity, and home range of bluegills in a shallow, natural Great Plains lake. A total of 78 bluegills (200–273 mm total length) were implanted with radio transmitters in March and May 2000. Of these fish, 10 males and 10 females were randomly selected and located every 2 h during one 24-h period each month from April to September 2000. Bluegill movement peaked during midsummer; however, there was little difference in diel movements, suggesting relatively consistent movement throughout the 24-h period. Home range estimates (which included the 24-h tracking plus an additional six locations from the same fish located once per day for six consecutive days each month) ranged up to 172 ha, probably because only about half of the bluegills exhibited site fidelity durin...
Evaluation of an electrified mat as a white-tailed deer ( Odocoileus virginianus ) barrier

White-tailed deer (Odocoileus virginianus) pose economic and safety problems for agricultural and transportation industries. We tested an electronic mat to determine if it would reduce deer crossing through fence openings. We measured deer intrusions and corn consumption at five sites with charged mats and five sites with non-charged mats. Weekly intrusions at treated sites decreased an average of 95% from pre-treatment. Weekly intrusions at control sites were reduced 60% during weeks 1 and 2 and increased to 10% reduction by week 6. Weekly corn consumption at treated sites decreased from pretreatment through all treatment weeks. Weekly corn consumption at control sites decreased in weeks 1‐4 and 6 but was not different from pre-treatment in week 5. Consumption remained higher than expected at treated sites because deer jumped over or broke through the fence that delineated sites. Based upon the conditions and results of this test, we believe that electrified mats could reduce deer passage through fence openings.
Effects of frequent marijuana use on memory-related regional cerebral blood flow

It is uncertain whether frequent marijuana use adversely affects human brain function. Using positron emission tomography (PET), memory-related regional cerebral blood flow was compared in frequent marijuana users and nonusing control subjects after 26+ h of monitored abstention. Memory-related blood flow in marijuana users, relative to control subjects, showed decreases in prefrontal cortex, increases in memory-relevant regions of cerebellum, and altered lateralization in hippocampus. Marijuana users differed most in brain activity related to episodic memory encoding. In learning a word list to criterion over multiple trials, marijuana users, relative to control subjects, required means of 2.7 more presentations during initial learning and 3.1 more presentations during subsequent relearning. In single-trial recall, marijuana users appeared to rely more on short-term memory, recalling 23% more than control subjects from the end of a list, but 19% less from the middle. These findings indicate altered memory-related brain function in marijuana users.
Kinetics of CO2 methanation over Ru/γ-Al2O3 and implications for renewable energy storage applications

Kinetics of CO₂ hydrogenation over a 10% Ru/γ-Al₂O₃ catalyst were investigated using thermogravimetric analysis and a differential reactor approach at atmospheric pressure and 230–245 °C. The data is consistent with an Eley–Rideal mechanism where H2 gas reacts with adsorbed CO₂ species. Activation energy, pre-exponential factor and reaction orders with respect to CO₂, H₂, CH₄, and H₂O were determined to develop an empirical rate equation. Methane was the only hydrocarbon product observed during CO₂ hydrogenation. The activation energy was found to be 66.1 kJ/g-mole CH₄. The reaction order for H₂ was 0.88 and for CO₂ 0.34. Product reaction orders were essentially zero. This work is part of a larger study related to capture and conversion of CO₂ to synthetic natural gas.
Test of a Flat Slab Reinforced with Welded Wire Fabric

The behavior at various stages of loading of a flat slab reinforced with welded wire fabric is described. The design was based on the empirical design method of ACI 318-56. The test structure was loaded at 16 points in each of its nine panels to simulate a uniform load. From three of a series of tests conducted at different load levels and with different combinations of loaded panels, representative load-deflection curves are given. At working load, the behavior of the structure was characterized by small deflections and stresses. The structure was essentially uncracked after reaching design load. Under increased loading, the stresses and deflections increased at an increasing rate as cracking progressed at failure at 955 psf. Comparison of the computer and design unit moments showed the structure to be adequately designed. However, the distribution of reinforcement was inefficient. The indication of the tests is that high-strength steel can be used efficiently and that the empirical method of design can be made simpler.
Light absorption by phytoplankton and minerogenic particles in Cayuga Lake, New York

Features of light absorption are critical determinants of the underwater and emergent light fields of lakes. Patterns in time and space of the components ( a x ) of the light absorption coefficient ( a ), and their dependence on various optically active constituents (OACs), in the form of material-specific a x , were resolved for Cayuga Lake, New York, USA. Component a was partitioned according to the additive components of ax that include phytoplankton ( a ϕ ), nonalgal particles ( a NAP ), and colored dissolved organic material ( a CDOM ). Specific absorption coefficients were developed that couple the concentration of chlorophyll a (Chl- a , an OAC) to a ϕ , and the concentration of inorganic suspended particulate material (ISPM, an OAC), or the projected area of minerogenic particles per unit volume of water (PAV m , an alternate OAC), to a NAP . The critical role of such specific coefficients in contemporary strategies to retrieve OACs through remote sensing for inland waters is described, and characteristics consistent with the influences of pigment packaging and accessory pigments on the a ϕ –Chl- a relationship are demonstrated. Nonalgal partical a NAP is reported to be primarily regulated by the level of minerogenic particles. The specific absorption coefficients developed for Cayuga Lake to support retrieval of the OACs of Chl- a , PAV m , and ISPM are considered in the context of the limited populations of estimates available for inland waters.
Mechanisms Restricting Diffusion of Intracellular cAMP

Although numerous receptors stimulate cAMP production in a wide array of cells, many elicit distinct, highly localized responses, implying that the subcellular distribution of cAMP is not uniform. One often used explanation is that phosphodiesterases, which breakdown cAMP, act as functional barriers limiting diffusion. However, several studies refute the notion that this is sufficient, suggesting that phosphodiesterase-independent movement of cAMP must occur at rates slower than free diffusion. But, until now this has never been demonstrated. Using Raster Image Correlation Spectroscopy (RICS), we measured the diffusion coefficient of a fluorescently-labeled cAMP derivative (φ450-cAMP) as well as other fluorescent molecules in order to investigate the role that molecular size, cell morphology, and buffering by protein kinase A (PKA) play in restricting cAMP mobility in different cell types. Our results demonstrate that cytosolic movement of cAMP is indeed much slower than the rate of free diffusion and that interactions with PKA, especially type II PKA associated with mitochondria, play a significant role. These findings have important implications with respect to cAMP signaling in all cells.
Benefit Enhancement in Public Employee Defined Benefit Pension Plans: Evidence from Three Sources

This study examines the prevalence, costs, and deferred compensation levels associated with pension plan benefit enhancement provisions often referred to as pension padding or spiking. Due to the difficulty to obtain data, three diverse sources of evidence are used: (1) an examination of reports on pension benefit enhancement presented in the financial press; (2) a survey of managers of state and local public employee pension plans; and (3) an empirical evaluation of two unique datasets of retiree characteristics and salary histories. We find evidence of excessive costs in the financial press, prevalence of overtime inclusion and loose limits on salary growth in the survey, and excessive near-retirement salary growth in the retiree data sets. This evidence suggests a strong principal-agent conflict circumventing a primary advantage of defined benefit pension plans, the ability to retain personnel with low costs during the near retirement period.
Length and Area Estimation with Visual and Tactile Stimuli

Why do the psychophysical functions for line length (linear) and area (compressive) differ and do they differ for both the tactile and visual modalities? Experiments 1A and B examined the effects of a two-dimensional perception on psychophysical functions for visual perception. Participants used magnitude estimation to judge the diameter, area, and circumference of a set of 14 circles. The psychophysical functions for diameter was approximately 1.0, for area was approximately .60, and for circumference was above 1.0, indicating that two-dimensional perception, per se, does not cause the compressive function for area. Obtaining spatial information without vision can be important for people with demanding graphically based decision-making tasks and people with visual impairments. Tactile interfaces provide an alternative way to display and obtain information. Do the tactile and visual modalities process spatial information in similar ways? Experiment 2 examined the correspondence between visual and tactile ...
Microwave Dielectric Properties of Standard Liquids: Numerical and Experimental Data

Dielectric spectroscopy has been established as a standard technique to study the interaction of electromagnetic waves with biological materials such as tissues and cells. In this work, we developed a MATLAB program to simulate the dielectric dispersion characteristics of three standard liquids using the Debye and Cole-Cole models. The liquids were water, methanol and ethanol, simulated in the microwave frequencies. In addition to plotting the real and imaginary parts of complex permittivity, as a function of frequency, we also developed a code to linearize the data by computing different mathematical combinations of the dielectric properties. We validated the models by using a Dielectric probe in conjunction with Agilent E5071C Automatic Network Analyzer (ANA), to measure the dielectric properties of these liquids between 100 MHz and 8.5 GHz frequency range, at a room temperature of about 20 degrees Celsius. We computed properties such as the relaxation time and the relaxation frequency, which were in good agreement with literature data. Results show a good agreement between the numerical and experimental data. This work will enhance the determination of the electrical properties of substances in biological and material sciences.
Raman Heterodyne Detection of NMR

A novel coherent Raman effect induced by an optical and a radio frequency (rf) field is used to detect nuclear magnetic resonance (NMR) in solids[1]. The technique, which employs heterodyne detection, is capable of monitoring coherent spin transients or nuclear resonances under cw conditions, both in ground and excited electronic states and with high sensitivity and precision. We illustrate the versatility of the method in a dilute rare earth impurity ion crystal, Pf3+: LaF3, where Pr3+ spin echoes of nuclear quadrupole transitions are detected not only in the 3H4 ground electronic state but also for the first time in the 1D2 excited state. From the cw spectrum, the Pr3+ hyperfine splittings in these electronic states as well as the magnetically broadened inhomogeneous lineshapes and widths are determined with kilohertz precision, about a five-fold improvement over earlier measurements. In Fig. 1, the Pr3+ electronhyperfine energy level diagram reveals the basic stimulated Raman process where two coherent fields, one at the optical field ωE (solid arrow), and the other at the rf frequency ωH (squiggle arrow) drive two coupled transitions resonantly. The electric dipole allowed optical transition, and the magnetic dipole allowed quadrupole transition to combine in a two-quantum process to generate a coherent optical field at the sum frequency ωE + ωH (dashed arrow). In addition, a Stokes field at the difference frequency ωE − ωH (not shown), due to the second resonant packet, accompanies the above anti-Stokes field. To predict the characteristics of the Raman heterodyne beat signal, we have performed a new three-level perturbation calculation, which yields a dispersive or absorptive near-Gaussian lineshape (opencircles, Fig. 1) in close agreement with experiment (solid curves).
E2F coregulates an essential HSF developmental program that is distinct from the heat-shock response

Heat-shock factor (HSF) is the master transcriptional regulator of the heat-shock response (HSR) and is essential for stress resilience. HSF is also required for metazoan development; however, its function and regulation in this process are poorly understood. Here, we characterize the genomic distribution and transcriptional activity of Caenorhabditis elegans HSF-1 during larval development and show that the developmental HSF-1 transcriptional program is distinct from the HSR. HSF-1 developmental activation requires binding of E2F/DP to a GC-rich motif that facilitates HSF-1 binding to a heat-shock element (HSE) that is degenerate from the consensus HSE sequence and adjacent to the E2F-binding site at promoters. In contrast, induction of the HSR is independent of these promoter elements or E2F/DP and instead requires a distinct set of tandem canonical HSEs. Together, E2F and HSF-1 directly regulate a gene network, including a specific subset of chaperones, to promote protein biogenesis and anabolic metabolism, which are essential in development.
The V-synth system

The V-synth system, a major updating of the MIMOLA software system, is described. A brief overview of MIMOLA is presented, followed by description of the changes made to it. These changes include integration of MIMOLA into the VHDL environment, development of a tool called the process graph analyzer, the changes to the MIMOLA control structure, and the addition of the capability to accept pipelined designs as input. >
The End of Muslim Sicily

This chapter focuses on the dramatic changes in the lives of Sicilian Muslims at the end of the twelfth century and the transformation of their portrayal in Latin sources. Birk traces the ways in which a series of dynastic crises led to a reemergence of Christian mob violence against Muslims. He shows that Sicilian rulers, nonetheless, assumed that Muslims could serve as a symbol of their power if they could regain control over them. Birk then highlights Pope Innocent III’s argument that Markward of Anweiler’s association with Muslims made him an enemy of the church. Birk argues that this marks an innovation in the discourse surrounding Sicilian Muslims, as it was the first time that a writer presented Muslim service as negative, rather than symbolic of royal power.
Control Loop Tuning and Surge Response for Hanford WTP Melter Offgas Systems

This report describes control loop tuning in models of the high level waste (HLW) melter offgas system, the low activity waste (LAW) melter offgas system and the HLW Pulse Jet Ventilation system and an assessment of the response to steam surges in both melter offgas systems. The three offgas systems were modeled using the Aspen Custom Modeler (ACM) software. The ACM models have been recently updated. Flowsheets of the system models used in this study are provided in Appendix D. To facilitate testing, these flowsheets represent somewhat simplified versions of the full models. For example, the HLW and LAW vessel ventilation systems have been represented as fixed air sources that provide a constant gas flow and specified air surges. Similarly, the six tanks and individual pulse-jet air sources in the HLW Pulse Jet Ventilation system are represented as a constant air source for control loop tuning purposes. The second LAW melter system has also been represented as a constant flow air source and several other simplifications such as removing HLW and LAW control interlocks, submerged bed scrubber bypass lines, and pressure relief valves have been made.
Not Practicing What You Preach: Religion and Incongruence Between Pornography Beliefs and Usage

Religious Americans, and conservative Protestants in particular, have historically been the most ardent opponents of pornography’s production, dissemination, and use. Yet while religiously committed and theologically conservative Americans are generally less likely to view pornography than others, the difference is often not as great or consistent as one might suppose given their strong moral stance. Drawing on insights from religious incongruence theory, this study considered whether religious commitment and theological conservatism predicted a greater incongruence between what Americans say they believe about pornography morally and whether they actually watch it. Data are taken from the nationally representative 2006 Portraits of American Life Study (N = 2,279). Analyses show that greater religious service attendance and prayer frequency are predictive of American men (not women) affirming that viewing pornography is “always morally wrong” while still viewing it in the previous year. Evangelicalism and...
Abstract 3249: Thymoquinone inhibits elongation factor 2 kinase signaling axis by inducing tumor suppressor miR-603 in triple negative breast cancer cells

Triple negative breast cancer (TNBC), is a highly heterogeneous and aggressive subtype of breast cancer (BC), which poses a significant clinical challenge. TNBC constitutes about 15-20 % of BC cases, and is characterized by lack of estrogen (ER), progesterone (PR) and human epidermal growth factor 2 (HER2) receptors. Thus, patients cannot benefit from targeted therapies such as anti-estrogens (eg.Tamoxifen) and anti-HER2 (eg.trastuzumab) treatments. Therefore, identification of new molecular targets and treatment strategies are highly warranted to improve patient outcome. We previously reported that elongation factor 2 kinase (EF-2K) is highly expressed in TNBC cell lines and is associated with poor patient survival and prognosis. Furthermore, in vivo targeting of EF-2K by siRNA nano-therapeutics inhibited cell proliferation, migration/invasion, and significantly decreased tumor growth in 2 different orthotopic TNBC mouse models (MDA MB-231 and MDA MB-436). Collectively, our work suggests that EF-2K is an excellent novel therapeutic target in TNBC. In search of a potential safe and effective EF-2K inhibitor, we identified Thymoquinone (TQ), a dietary natural compound, known to have diverse anti-cancerous properties in several in vitro and in vivo models, including TNBC. However, the mechanism by which TQ mediates its effects are not well elucidated. Our current study is the first to demonstrate that TQ inhibits protein and mRNA expression of EF-2K, as well as its clinically significant downstream targets such as Src/FAK, PI3K/AKT, and CyclinD1; resulting in a significant decrease in proliferation, migration/invasion of TNBC cells. To determine the molecular mechanism by which TQ inhibits EF-2K expression, we investigated if TQ induces tumor suppressor microRNAs that we identified to bind to the 3’-UTR of EF-2K. We found that TQ induces miR-603 expression, which we had reported to directly bind and inhibit EF-2K expression; resulting in decreased TNBC growth and progression, both in vitro and in vivo. Furthermore, we showed that inhibition of nuclear factor kappa B (NF-κB) (a well established target for TQ), also induces miR-603 and inhibits EF-2K expression in TNBC cells. In conclusion, our study is the first to show that TQ treatment decreases EF-2K expression through modulating the NF-κB/miR-603 axis; ultimately resulting in decreased cell proliferation, migration/invasion of TNBC. Our data suggests a novel molecular mechanism for TQ that represents a potential therapeutic strategy in inhibiting TNBC tumor growth and progression. Citation Format: Nashwa N. Kabil, Recep Bayraktar, Nermin Kahraman, Bulent Ozpolat. Thymoquinone inhibits elongation factor 2 kinase signaling axis by inducing tumor suppressor miR-603 in triple negative breast cancer cells [abstract]. In: Proceedings of the American Association for Cancer Research Annual Meeting 2017; 2017 Apr 1-5; Washington, DC. Philadelphia (PA): AACR; Cancer Res 2017;77(13 Suppl):Abstract nr 3249. doi:10.1158/1538-7445.AM2017-3249
Materials Science Literature-Patent Relevance Search: A Heterogeneous Network Analysis Approach

In recent decades, materials science literature and patents have grown exponentially. This has also contributed to an ever-growing challenge whether the literature is current, as there can be a gap between when the patent was filed and when it was approved. Moreover, it is difficult to ensure that a patent cites the appropriate prior art due to variety and volume of materials science data, especially when it is in two separate sources that have different curation mechanisms and purpose – publications and patents. The existing relational database schema, generally used to store publications, also presents challenges given the strict tabular schema, which may not be appropriate for organizing and querying highly interconnected information about materials in these publications and patents. For example, elements are chemically combined to form a compound, which can then be converted to other compounds via chemical reactions. Furthermore, relational database is not designed for handling combining data from multiple sources and with various formats, thus it makes discover relevance between publications and patents become difficult. In order to explore an alternative approach to represent materials data and combine data from multiple sources into the same repository, in this work, we propose a solution to integrate data from Open Quantum Materials Database (OQMD) and patent data from USPTO1 database into a network and named it heterogeneous materials information network (HMIN). We generalize prior work which based on using meta path-based topological features to explore the network, and we propose features to identify network noise and investigate relatedness between different-typed objects to meet our application needs. We built several machine learning models by using these features to explore relevance between materials science publications and patents. Experiment results show that HMIN can help researchers effectively discover related publications and patents originally kept in different sources. Our work exhibits to materials community a new way of appro-priately representing materials data and discovering connections between data from multiple sources.
Validation of imaging-based quantification of glenohumeral joint kinematics using an unmodified clinical biplane fluoroscopy system

Model-based tracking, using CT and biplane fluoroscopy, allows highly accurate quantification of glenohumeral motion and changes in the subacromial space. Previous investigators have used custom-built biplane fluoroscopes designed specifically for kinematic applications, which are available at few institutions and require FDA approval prior to clinical use. The aim of this study was to demonstrate the utility of an off-the-shelf clinical biplane fluoroscope for kinematic applications by validating model-based tracking for measurement of glenohumeral motion using an unmodified clinical system. Biplane images of each shoulder of a cadaver torso were acquired at various joint positions and during simulated movements along anatomical planes of motion. The pose of each humerus and scapula was determined using model-based tracking and compared to a bead-based gold standard. Error due to a temporal-offset between corresponding biplane images, characteristic of clinical biplane systems, was determined by comparison of measured and known relative position of 2 bead clusters of a phantom that was imaged while moved throughout the fluoroscopy image volume. Model-based tracking had global kinematic mean absolute errors of 0.27 mm and 0.29° (static), and 0.22-0.32 mm and 0.12-0.45° (dynamic). Glenohumeral mean absolute errors were 0.39 mm and 0.45° (static), and 0.36-0.42 mm and 0.41-0.48° (dynamic). The temporal-offset was predicted to add errors of 0.06-0.85 mm and 0.05-0.28° for cadaveric trials for the speeds examined. For defined speeds, sub-millimeter and sub-degree kinematic accuracy and precision were achieved using an unmodified clinical biplane fluoroscope for quantification of glenohumeral motion.
From Chi-Raq to Iraq: The retreat of the state and the rise of organized violent nonstate actors:

Spike Lee’s latest film, Chi-Raq, draws upon a portmanteau coined by local rappers to describe the violence and chaos of Chicago’s South Side, home of some of the most violent neighborhoods in Amer...
The History of Quantitative Neuroanatomy

For several centuries neuroanatomists have been looking at tissue in the light microscope, describing what they see in words, and drawing pictures of the structures that they see contained in the tissue. Microscope equipment and viewing techniques have developed over the decades, as have histological procedures for preparing the tissue for the researcher’s examination. Independently, the computer field has been blossoming, but at a much more rapid pace. The pressures of World War II caused the first digital computers to be developed for practical use. Through the 1950s and 1960s, large computers were developed for military, banking, and census work. These machines were far too expensive and cantankerous for a biological research laboratory. In the late 1960s, however, the laboratory computer began to appear at a price within the range of well-funded research laboratories. At this time, the two fields, computers and biological research, began to merge. And in the last 20 years, the laboratory computer has been applied to almost every laboratory task. This book describes the computer’s application to neuroanatomy and its role in collecting and analyzing the shapes and functions of anatomic structures.
Erectile Dysfunction: Initial Evaluation

Erectile dysfunction (ED) is defined as the consistent inability to obtain and/or maintain an erection sufficient for satisfactory relations. It is estimated to affect 50 % of men over 40 years of age. This translates into more than 20 million men in the USA and over 100 million men worldwide suffering from this problem. It is associated with significant decrease in self-confidence, self-esteem, and quality of life. In its organic form it is most commonly associated with vascular risk factors such as hypertension, dyslipidemia, diabetes, obesity, cigarette smoking, and coronary artery disease. Other conditions associated with the development of ED include radical pelvic surgery or radiation, sleep apnea syndrome, neurological conditions (lumbosacral disk disease, Parkinson’s disease, stroke), medications including some antidepressants and antihypertensives (Table 7.1) and endocrine conditions including hypogonadism, hyperprolactinemia, and thyroid dysfunction.
Ovarian and Endometrial Cancer in Patients with Hereditary Non-polyposis Colorectal Cancer Syndrome

In this era of personalized medicine, genetic susceptibility to cancer is quickly becoming one of the most researched areas of the biomedical sciences. In addition, greater public understanding of the role that genes play in the development of cancer and potential testing requires that today’s physician be aware of these genetic predispositions, understand how to take a detailed family history, and be knowledgeable about the testing at his/her disposal. Hereditary non-polyposis colorectal cancer (HNPCC) is one such heritable, cancer susceptibility syndrome. The care of patients with this syndrome requires orchestrated efforts by gastroenterologists, gynecologists, surgeons, medical oncologists, and geneticists.
Use of Colchicine and Steroids in the Treatment of Alcoholic Liver Disease

To date, only one group has reported its clinical experience with colchicine therapy. This study included a randomized clinical trial of 22 patients and an open study of 53 patients. The beneficial effect of 1 mg colchicine daily for five days a week has been promising but not convincing.
Investigation of Type 1 Copper Site Geometry by Spectroscopy and Molecular Redesign

Resonance Raman (RR) spectra of type 1 Cu proteins (cupredoxins) show a multiplicity of vibrational fundamentals between 250 and 500 cm-1 that is ascribed to kinematic coupling of the Cu-S(Cys) stretch with deformations of the Cys and His ligand side chains. A similar set of vibrational frequencies is observed for 11 different cupredoxins. These findings suggest that all cupredoxins have a highly conserved Cu(His)2Cys geometry including (i) a trigonal planar array for the three Cu ligands and (ii) a coplanar arrangement of the Cu-S-C s-Cα-N atoms in the Cu-cysteinate moiety.
SOME EXTENSIONS OF A SYSTEM FOR INFERENCE ON PARTIAL INFORMATION1

Some extensions of a system for inference on partial information, which uses production rules, are described. Basically, the system consists of RULES, an active set of rules (a subset of potentially large set of rules), partially ordered by specificity, and FACTS, a small active set of facts (a subset of potentially large set of data base facts). The critical feature of the inference method is that only a partial match of the antecedent of a rule is needed. Some selected extensions of the system are presented. These concern some approaches to the problems of selecting from an ambiguous response and, more importantly, transforming or dynamic clustering of FACTS and RULES. This latter problem is important because partial match is defined over the sets RULES and FACTS, and unless these sets are reasonably small, partial match can be an unmanageable operation. Several issues concerning the use of this inference system in certain applications are also briefly discussed.
The Montana 2013 Biennium Budget

DOI 10.1515/cjpp-2012-0034 Calif. J. Politics Policy 2012; 4(3): 161–181 Research Article Jeffrey D. Greene* The Montana 2013 Biennium Budget Abstract: Montana’s legislature meets once every two years and constructs a two- year budget. The legislature was controlled by Republicans following the trend of the 2010 mid-term elections but with a Democratic governor who vetoed numer- ous pieces of legislation. The most significant aspect of the legislative session was the contentious nature of the clash between Republicans, Democrats, and the governor over spending. Republicans attempted to cut spending despite the fact that revenues were much higher than originally expected. The state did not have implement significant spending cuts but the fiscal year. However, the fiscal year, which begins July 1, 2013, does not look promising for Montana and budget shortfalls are expected. Keywords: budgeting; fiscal year; Montana; western state budget report *Corresponding author: Jeffrey D. Greene, Professor, Department of Political Science, University of Montana, Missoula, MT 59812, Phone: +406-243-6181, e-mail: jeffrey.greene@mso.umt.edu 1 Introduction Governor Schweitzer submitted his budget, which was roughly a 2% increase over that the previous biennium’s budget. The governor claimed his goals were to boost school and university funding while cutting property taxes for home- owners and eliminating equipment taxes for most businesses (Johnson 2010a). Overall, Montana was in better fiscal shape than most states despite the fact that a budget shortfall was expected to be $400 million in the fall of 2010. This sounds like a small amount compared to large states like California and Texas, but for Montana it is significant (Dennison 2010; Johnson 2010a; Walsh 2011). Montana has never had a reputation for overspending. While the state has a reputation for making accurate revenue estimates, there is a long history of the legisla- ture creating a “barebones budget” that inadequately funds state services. This turned out to be a plus in light of the national economic crisis, but Montana’s economy had not performed as badly as the economies of many states. By the time the session started revenue predictions had improved. Experts predicted a
Bilateral high-frequency hearing loss is associated with elevated blood pressure and increased hypertension risk in occupational noise exposed workers.

Objective To investigate the association of bilateral high-frequency hearing loss (BHFHL) with blood pressure and hypertension among occupational noise exposed workers. Methods Occupational noise exposed workers were enrolled in 2017 from the occupational diseases survey of Chengdu. BHFHL was classified as normal, mild, or high by the bilateral high-frequency tone average. Linear regression model was used to assess the effects of occupational noise exposure time and BHFHL on blood pressure. Logistic regression model was performed to estimate hypertension risk odds ratios (ORs) associated to occupational noise exposure time and BHFHL. Results Increasing years of occupational noise exposure and BHFHL were significantly associated with systolic and diastolic blood pressure increase (all P<0.001). The lineal trend was only significant in males, with adjusted ORs for hypertension gradually increasing with increasing years of occupational noise exposure (P<0.001). Furthermore, subjects having mild and high BHFHL had a higher hypertension risk of 34% and 281%, respectively (both P<0.001). Dose-response relationship between BHFHL and hypertension was found in both males and females. Conclusions Occupational noise exposure was positively associated with blood pressure levels and hypertension risk.
Atrial cardiopathy and stroke mortality in the general population.

BackgroundPrior studies examining the link between atrial cardiopathy and stroke risk have focused mainly on non-fatal stroke.AimsTo examine the association between atrial cardiopathy and stroke mo...