cssi/SciSciGPT-SciSciNet huggingface dataset:
Economic benefits of using adaptive predictive models of reproductive toxicity in the context of a tiered testing program.

A predictive model of reproductive toxicity, as observed in rat multigeneration reproductive (MGR) studies, was previously developed using high throughput screening (HTS) data from 36 in vitro assays mapped to 8 genes or gene-sets from Phase I of USEPA ToxCast research program, the proof-of-concept phase in which 309 toxicologically well characterized chemicals were testing in over 500 HTS assays. The model predicted the effects on male and female reproductive function with a balanced accuracy of 80%%. In a theoretical examination of the potential impact of the model, two case studies were derived representing different tiered testing scenarios to: 1) screen-out chemicals with low predicted probability of effect; and 2) screen-in chemicals with a high probability of causing adverse reproductive effects. We define ‘testing cost efficiency’ as the total cost divided by the number of positive chemicals expected in the definitive guideline toxicity study. This would approach $$2.11 M under the current practic...
CaF2 Solid Electrolytes Used to Study Thermodynamics of Alloys

Galvanic cells using CaF2 as a solid electrolyte are described for obtaining thermodynamic and phase equilibria data on alloys both in the liquid and solid state. The method of coulometric titration, which controls the composition of alloy electrodes very accurately, is also explained. Results yield information on the Gibbs energies of mixing for liquid phases. In the solid state the method identifies what intermetallic compounds are present in a binary system as well as their range of homogeneity and Gibbs energy of formation. This information combined with appropriate atomic models gives the type and degree of atomic or electronic disorder present in the intermediate phase. Examples will be presented for binary systems involving alkali and alkaline earth metals and alkali metals dissolved in their alkali halides.
Resonance, Leadership, and the Purpose of Life

This note describes the world-class-performance model developed by Dr. Doug Newburg at the University of Virginia Medical Center. Newburg's sample includes Olympic athletes, successful CEOs, world-famous musicians, and leading heart surgeons. The model also relates to the concept of flow developed by Cziksentmihalyi at the University of Chicago, and suggests an answer to the tough question, What is the meaning of life? The note is provocatively useful in courses on leadership, career management, and organizational behavior.
Primary CNS T-cell Lymphomas: A Clinical, Morphologic, Immunophenotypic, and Molecular Analysis.

Primary central nervous system (CNS) lymphomas are relatively rare with the most common subtype being diffuse large B-cell lymphoma. Primary CNS T-cell lymphomas (PCNSTL) account for 1 mutation, and none showed overlapping mutations. These included mutations in DNMT3A, KRAS, JAK3, STAT3, STAT5B, GNB1, and TET2 genes, genes implicated previously in other T-cell neoplasms. The outcome was heterogenous; 2 patients are alive without disease, 4 are alive with disease, and 6 died of disease. In conclusion, PCNSTLs are histologically and genomically heterogenous with frequent phenotypic aberrancy and a cytotoxic phenotype in most cases.
New or Noteworthy Basidiomycetes from the Central Rocky Mountain Region

This paper deals with some new or noteworthy species of Ba? sidiomycetes collected in Colorado and Wyoming during the sum? mer of 1929 by the senior author from the New York Botanical Garden, and the junior author from the University of Colorado and a resident of Colorado. A brief synopsis of the activities of the authors during the summer of 1929 has previously been pub? lished (7). Also, a report covering the rusts which were col? lected has already been made (9). Based entirely or in part upon the Basidiomycetes collected. in 1929, one new genus and two new species have already been re? ported, as follows: Calbovista subsculpta Morse (Mycologia 27: 97. 1935) and Phlebia mellea Overholts (Mycologia 22: 241. 1930). This present paper presents one additional new species. Complete and annotated check-lists of all the Basidiomycetes, except the rusts, collected by the authors in Colorado, Wyoming, and South Dakota, will appear in the " University of Colorado Studies," Volume 23, number 2. 1935. This paper deals with one new species, and other species of interest in respect to their geographical and altitudinal distribution, host relations, and morphological characteristics.
Electrocatalysis of Oxygen Reduction on Nonprecious Metallic Centers at High pH Environments

Iron(III) tetraphenyl porphyrin (FeTPP) macrocycle supported on high surface area Black Pearl Carbon prepared by ball milling and subsequent pyrolysis under inert atmosphere at 600{degree sign}C to 800{degree sign}C exhibits remarkable 4e- oxygen reduction reaction activity with minimal peroxide yield in alkaline medium. The pyrolytic evolution of the catalytic site has been systematically investigated using a combination of two powerful techniques, i) Square Wave Voltammetry (SWV) capable of isolating the Faradaic charge transfer from the non-Faradaic capacitive current and ii) in situ X-ray Absorption Near Edge Spectroscopy (XANES). Using these techniques we clearly show here clearly the two advantages obtained by pyrolysis in the case of FeTPP. i) Anodic shift in redox potential of the iron metal center and ii) the formation of a mixed-valence dimeric catalyst site capable of binding molecular oxygen and enable charge transfer in a concerted fashion.
Discussion and Analysis on the Construction and Development of Hospital Websites under the New Circumstance

The paper states that exploring a proper way for structuring and developing websites to meet the hospital and social demands is the problem which needs to be solved urgently.For this,it provides certain methods to improve the reality including improving content quality based on the health demands,expanding service content,modifying management and maintaining mechanism,constructing effective websites promotion measures,integrating uniform information release platform,performing scientific evaluation and supervision, etc.
Automated Promotion of Technology Acceptance by Clinicians Using Relational Agents

Professionals are often resistant to the introduction of technology and can feel threatened if they perceive the technology as replacing some aspect of their jobs. We anticipated some of these problems in the process of introducing a bedside patient education system to a hospital, especially given that the system presents itself as a “virtual discharge nurse” in which an animated nurse agent interacts with patients using simulated face-to-face conversation. To increase acceptance by nursing staff we created a version of the character designed to build trust and rapport through a personalized conversation with them. In a randomized trial, we compared responses after 15 minute in-service briefings on the technology versus responses to the same briefings plus a personalized conversation with the agent. We found that the nurses who participated in briefings that included the personalized conversation had significantly greater acceptance of and lower feelings of being threatened by the agent.
The Convergent Validity of Selected Methods of Determinant Attribute Identification: Some Preliminary Findings

Researchers have been questioning the methodology of determinant attribute identificaUon for the past few years. The objective of this research project is to test the convergent validity of four different methods of determinant attribute identification. Results of the project suggest that the four methods produce varying results.
Diastolic pulmonary gradient predicts outcomes in group 1 pulmonary hypertension (analysis of the NIH primary pulmonary hypertension registry).

Abstract Background Diastolic pulmonary gradient (DPG), calculated as the difference between pulmonary artery diastolic pressure and mean pulmonary capillary wedge pressure ≥ 7 mmHg is associated with pulmonary vascular disease and portends poor prognosis in heart failure (HF). The prognostic relevance of DPG in group 1 pulmonary hypertension (PH) is uncertain. Methods Using the Pulmonary Hypertension Connection (PHC) risk equation for 225 patients in the NIH-PPH, the 5-year probability of death was calculated, which was then compared with DPG using a Cox proportional hazards model. Kaplan-Meier survival curves were determined for two cohorts using the median DPG of 30 mmHg as cutoff, and significance was tested using the log-rank test. Results The mean age was 38.1 ± 16.0 years old, 63% female, and 72% were “white”. The mean DPG was 31.6 mmHg ± 13.8 mm Hg and only 1.8% had a DPG 30 mm Hg with respect to 5-year mortality was 2.03. After adjustment for pulmonary artery systolic pressure (PASP), increasing DPG remained significantly associated with decreased 5 years survival (HR 1.99 for DPG > 30 mm Hg). Conclusions DPG is independently associated with survival in group 1 PH patients even after adjustment for the PHC risk equation or PASP. Patients with increased DPG had a 2-fold increased risk of mortality. The use of DPG for guiding treatment and prognosis in group 1 PH should be further investigated.
Prevalence and Risk Factors of Peri-ictal Autonomic Changes in Children With Temporal Lobe Seizures

Abstract Background We determined the prevalence of signs and symptoms of autonomic dysfunction in seizures of temporal lobe onset in children. Methods We evaluated the prevalence and risk factors of peri-ictal autonomic changes in temporal lobe onset seizures in children from a single-center pediatric epilepsy monitoring unit between June 1, 2009 and October 31, 2013. Age, gender, epilepsy etiology, current antiepileptic drug therapy, ictal electroencephalographic lateralization, brain magnetic resonance imaging results, and the presence of generalized tonic-clonic seizures over the preceding year were recorded from medical record review. Results Forty-nine children were identified (55% male, median age 10.1 years [interquartile range 5.5 to 13.9 years]). Overall, peri-ictal autonomic changes were observed in 32 of 49 patients (66%) and 91 of 172 evaluated seizures (53%). Tachycardia (51%), oxygen desaturation (33%), and salivation (27%) were the most frequent autonomic changes identified. Bradycardia occurred in one patient (2%). Conclusions Among pediatric patients with temporal lobe seizures, peri-ictal autonomic changes are frequent yet seldom require intervention.
Who Is Socrates and Why Should We Read Him

This chapter introduces the figure of Socrates and what we currently know about him. His commitment and approach to teaching are discussed, as well as the superiority of the “classics” as teaching vehicles in college.
Heart Failure Management and Development of Heart Failure Programs

Advances in the treatment of HF and early interventions to prevent clinical decompensation delay disease progression and improve survival. After initial evaluation and the implementation of guideline-directed medical therapy, outpatient HF management strategies focus on the maintenance of patient stability. Multidisciplinary disease-management HF programs may help improve HF patient outcomes, including decreased symptoms, improved quality of life, reduced rates of hospital admission, and decreased healthcare costs. The principals of effective HF care include: a patient-centered multidisciplinary approach, rigorous adherence to evidence-based treatment through written protocols, early detection of exacerbations, development of individualized management plans, promotion of patient self-management, continuity of care, and continuous monitoring of program outcomes and quality improvement.
Left Ventricular Concentric Remodeling Is Associated With Decreased Global and Regional Systolic Function

Background— The transition from compensatory concentric remodeling to myocardial failure is not completely understood in humans. To investigate determinants of incipient myocardial dysfunction, we examined the association between concentric remodeling and regional LV function in asymptomatic participants of the Multi-Ethnic Study of Atherosclerosis (MESA). Methods and Results— Myocardial tagged MRI was performed. Regional myocardial function expressed as peak systolic midwall circumferential strain (Ecc) was analyzed in 441 consecutive studies by HARP (Harmonic Phase) tool. Peak Ecc was correlated with the extent of concentric remodeling determined by the ratio of left ventricular mass to end-diastolic volume (M/V ratio). In men, a gradual decline in peak global Ecc was seen with increasing M/V ratio (test for trend, P<0.001). Among women, however, Ecc tended to be lower only in the fifth compared with the first quintile of M/V ratio (P=0.1). The association of lower Ecc with increasing M/V ratio was regi...
Automated Layout Synthesis and Visualization from Images of Interior or Exterior Spaces

Recent work in computer graphics has explored the synthesis of indoor spaces with furniture, accessories, and other layout items. In this work, we bridge the gap between the physical and virtual worlds: Given an input image of an interior or exterior space, and a general user specification of the desired furnishings and layout constraints, our method automatically furnishes the scene with a realistic arrangement and displays it to the user by augmenting the original image. Our method can deal with varying layouts and target arrangements at interactive rates, which affords the user a sense of collaboration with the design program, enabling the rapid visual assessment of various layout designs, a process which would typically be time consuming if done manually. Our method is suitable for smartphones and other camera-enabled mobile devices.
Gods r us

ii ACKNOWLEDGMENTS iv PREFACE v SIMILI 1 IN THE SHOWER THINKING OF ACTAEON 2 VENUS AND ADONIS 3 JOVE’S COLLAR 4 OR US 5 CADMUS IS HISTORY 6 APHRODITE: 7 ON THE TAIL 8 I AM LOOKING FOR THE EYES OF GOD AND ALL I SEE ARE HOLLOWS 9 NODE TO SPONTANIETY 10 OBJET D’ART 11 CUPID AND PSYCHE 12 MIDAS 13 AS PROMISED TITHONUS 14 MY DAUGHTER PHILOMELA 15 POEM, SISYPHUS 16 PAN ON PAN 17 GANGA JUMP 18 RAVANA’S GARDEN 21 MONKEY PUZZLE 23 ODE TO KALI 24 CAREFUL WHAT YOU WISH FOR 25 BRAHMA’S MOMENT 26 SHIVA’S DANCE 27 YAMA’S BUSINESS 28 FOR POOTANA’S SAKE 29 MAKE POVERTY HISTORY – INDIAN RESTAURANT, LONDON 30
Treatment of Tuberculosis Infection in Children

The last decade has seen publication of more robust data for shorter course regimens for tuberculosis infection. These regimens are associated with higher completion rates than the traditional 6- to 9-month course of daily isoniazid (INH). These shorter regimens include 4 months of daily rifampin (RIF) and 12 once-weekly doses of INH and a long-acting rifamycin and rifapentine. In addition, a widely used regimen in the United Kingdom is 3 or 4 months of daily INH and RIF. All regimens have demonstrated efficacy in the ideal conditions of clinical studies, and all have very low rates of hepatotoxicity in children. These newer regimens likely are more effective than longer courses of INH once patient and family adherence is considered. Clinicians need to be cognizant of poor completion rates with traditional INH therapy and how the use of rifamycin-containing regimens offers more palatable options for children and their families.
Novel Ca2+-dependent mechanisms regulate spontaneous release at excitatory synapses onto CA1 pyramidal cells.

We show that the predominant theories for explaining the regulation of spontaneous, action potential-independent synaptic release do not explain the sensitivity of this type of synaptic transmissio...
Skilled attendant at birth and newborn survival in Sub-Saharan Africa

Background Recent studies have shown higher neonatal mortality among births delivered by a skilled attendant at birth (SAB) compared to those who were not in sub-Saharan African countries. Deaths during the neonatal period are concentrated in the first 7 days of life, with about one third of these deaths occurring during the first day of life. We reassessed the relationship between SAB and neonatal mortality by distinguishing deaths on the first day of life from those on days 2-27. Methods We used data on births in the past five years from recent demographic and health survey (DHS) between 2010 and 2014 in 20 countries in sub-Saharan Africa. The main categorical outcome was 1) newborns who died within the first day of birth (day 0-1), 2) newborns who died between days 2-27, and 3) newborns who survived the neonatal period. We ran generalized linear mixed model with multinomial distribution and random effect for country on pooled data. Additionally, we ran a separate model restricted to births with SAB and assessed the association of receipt of seven antenatal care (ANC) and two immediate postnatal care interventions on risk of death on days 0-1 and days 2-27. These variables were assessed as proxy of quality of antenatal and postnatal care. Results We found no statistically significant difference in risk of death on first day of life between newborns with SAB compared to those without. However, after the first day of life, newborns delivered with SAB were 16% less likely to die within 2-27 days than those without SAB (OR = 0.84, 95% CI = 0.71-0.99). Among births with skilled attendant, those who were weighed at birth and those who were initiated early on breastfeeding were significantly less likely to die on days 0-1 (respectively OR = 0.42 95% CI = 0.29-0.62 and OR = 0.24, 95% CI 0.18-0.31) or on days 2-27 (OR = 0.60, 95% CI = 0.45-0.81 and OR = 0.59, 95% CI = 47-0.74, respectively). Newborns whose mothers received an additional ANC intervention had no improved survival chances during days 0-1 of life. However, there was significant association on days 2-27 where newborns whose mothers received an additional ANC interventions had higher survival chances (OR = 0.95, 95% CI = 0.93-0.98). Conclusion Findings demonstrate the vulnerability of newborns immediately after birth, compounded with insufficient quality of care. Improving the quality of care around the time of birth will significantly improve survival and therefore accelerate reduction in neonatal mortality in sub-Saharan African countries. Improved approaches for measuring skilled attendant at birth are also needed.
Pediatric heart transplantation at adult-specialty centers in the United States: A multicenter registry analysis.

Recent Organ Procurement and Transplantation Network bylaw revisions mandate that US transplant programs have an "approved pediatric component" in order to perform heart transplantation (HT) in patients 0.7; adult-specialty ratio 8 years). In propensity score-matched cohorts, we observed no difference in graft loss by center type (median survival: adult 12.4 years vs pediatric 9.2 years, P = .174). Compared to the matched pediatric cohort, adult-specialty center recipients lived closer to their transplant center (31 vs 45 miles, P = .012), and trended toward fewer out-of-state transplants (15 vs 25%, P = .082). Our data suggest that select adolescents can achieve similar midterm graft survival at centers organized primarily for adult HT care. Regardless of post-HT setting, the development of care models that demonstrably improve adherence may be of greatest benefit to improving survival of this high-risk population.
The Impact of Obesity on Orthopedic Upper Extremity Surgery

Obese patients have increased rates of upper extremity injury, carpal tunnel syndrome, and upper extremity osteoarthritis. Preoperative considerations include cardiovascular disease, pulmonary disease, and diabetes mellitus. Intraoperative and anesthetic considerations include specialized equipment, patient positioning, and the physiology of obese patients. Postoperative considerations should include increased risk of cardiovascular complications as well as surgical site infections and malunion. Surgery of the hand and upper extremity may be less prone to the postoperative complications seen in other regions of the body. There are currently no direct contraindications for obese patients to undergo orthopedic procedures if the appropriate considerations have been made.
Copper and the Regulation of Superoxide Dismutase Activity in Aortic Tissue

Understanding how cuproenzymes are regulated in connective tissues is vital to understanding the role copper and copper complexes play in ameliorating chronic inflammations. The rapidly growing chick aorta is an excellent model system to test the effects of copper availability on cuproenzyme production because chicks are readily made deficient, copper metabolism in aorta has been partially characterized through metabolic studies with lysyl oxidase, and chick aortas can be cultured in serum free media. The intent of this presentation is to describe some of the copper regulatory mechanisms being investigated for the aortic copper-zinc superoxide dismutase in chick.
Gene therapy for rheumatoid arthritis: preclinical studies

Originally intended as a tool for the correction of inborn errors of metabolism, gene transfer technology has revolutionized the development of novel treatments to acquired diseases, such as cancer, autoimmune, and chronic inflammatory conditions. The concept of gene therapy for rheumatoid arthritis (RA) was proposed as an alternative to inefficient conventional drug delivery to the affected joints [1]. In this approach, introduction of exogeneous genes into the synovium should afford expression of therapeutic proteins directly at the site of the disease, thereby obviating the problems of inefficient systemic protein delivery and sparing the host from the side-effects associated with the systemic exposure to recombinant proteins [2]. However, despite its conceptual simplicity, many principal problems of gene therapy for RA remain to be solved before it becomes a routine clinical procedure. Here, I will summarize what we have learned from the preclinical studies using animal models, and discuss some unresolved issues of gene therapy for RA.
FDG PET/CT imaging characteristics in multiple myeloma patients at staging and follow-up

1056 Learning Objectives On FDG PET/CT imaging, 1. Identify different patterns of the disease presentation at staging. 2. Recognize findings for recurrence and post-therapy presentations. 3. Understand and identify the potential pitfalls. Multiple myeloma (MM) is a plasma-cell malignancy, characterized by osteolytic lesions causing pathological fractures, cord compression and hypercalcemia. Depending on M-protein and plasma cell levels, disease spectrum varies from monoclonal gammopathy of undetermined significance (MGUS) to symptomatic MM. The bone lesions rarely heal even in complete remission. Sensitive imaging techniques are essential in the diagnosis, staging and restaging of MM. The Durie/Salmon-plus staging system incorporated FDG-PET or MRI information;focal lesion number, extent of bone marrow disease. The pattern of MM infiltration may be focal, multifocal or diffuse on FDG PET/CT. PET/CT is also helpful in detection of extramedullary MM. MM treatment protocol includes induction therapy followed by autologous stem cell transplantation (ASCT). The residual FDG activity after induction before ASCT portends a poor prognosis, prompting treatment changes. The detection of impending vertebral collapse, sequelae of prior fractures, detection of active MM in small lytic areas, differentiation of bone healing or arthritic changes from active MM, extramedullary MM or soft tissue components and infection is of crucial clinical value for management decisions. Bone marrow stimulation have PET characteristics similar to that of diffuse marrow infiltration posing a potential pitfall. In light of the increasing use of FDG PET/CT for MM staging and treatment monitoring, it is important to be familiarized with imaging findings and interpretative pitfalls to avoid false readings at both staging and restaging. This presentation will review most relevant PET/CT findings for MM by disease stage, treatment related findings, recurrence patterns and potential diagnostic pitfalls
GASTROPODA OF THE ESSEX FAUNA, FRANCIS CREEK SHALE (MIDDLE PENNSYLVANIAN), NORTHEASTERN ILLINOIS

Study of more than 140 siderite concretions from the Francis Creek Shale of Savage (1927) (Middle Pennsylvanian) in northeastern Illinois shows Euphemites to be the most abundant form. A new species, E. richardsoni , is described from the Pit Eleven locality in Will and Kankakee Counties. Strobeus is the next most common gastropod, but all specimens are imperfectly preserved. Two specimens of Straparollus (Euomphalus) sp. are available. Hypselentoma sp. and N. (Naticopsis) sp. are both represented by single specimens. None of these specimens is sufficiently well preserved to permit formal description. When compared with other midcontinent Pennsylvanian gray shales, the Essex biofacies of the Francis Creek Shale is characterized by low density, low diversity, and low evenness among marine gastropods.
Multimarket Contact in the Hospital Industry

Hospitals in the United States increasingly belong to multihospital systems that operate in numerous geographic markets. A large literature in management and economics suggests that competition between firms may be softened as a result of multimarket contact—ie., firms competing with one another in multiple markets simultaneously. Exploiting plausibly exogenous variation in multimarket contact generated by out-of-market consolidation, I find that increases in multimarket contact over the 2000–2010 period led to higher hospital prices. These results suggest that continued hospital consolidation may produce higher prices even if that consolidation only minimally affects within-market concentration.
Merkel Cell Carcinoma: A Comparison of Different Immunohistochemical Markers Useful in Diagnosis

Merkel cell carcinoma (MCC) is a rare and aggressive neuroendocrine carcinoma associated with a high mortality rate. A polyomavirus integrated into the genome of most tumors is thought to be pathogenic. MCCs may be difficult to distinguish from other small cell carcinomas, melanoma, lymphoma, and others. Immunohistochemical marker studies are essential for accurate and efficient diagnosis. Although the paranuclear dot-like pattern seen with staining for cytokeratin 20 is considered characteristic, antibodies directed at other cytokeratins such as cytokeratin 8 (CAM 5.2), pancytokeratins (AE1/AE3), and other clones that recognize low molecular weight cytokeratins are also useful for diagnosis. We set out to evaluate which stains are helpful in diagnosing the cases of MCC encountered in our patient population. A retrospective study of 59 cases of MCC from our files was performed. Each MCC was stained with a panel of IHC markers and evaluated for the staining pattern and intensity in an effort to identify the most efficient IHC stains useful in establishing a diagnosis of MCC. [N A J Med Sci. 2018;11(1):34-38. DOI: 10.7156/najms.2018.1101034]
Development of Aviation Management Coursework

Students graduating from aviation programs frequently move into careers that have a significant management component. As a result aviation management courses have evolved in aviation curricula to prepare graduates for these positions. However, many of these courses fall far short of their potential because relatively few aviation faculty are prepared to teach in this area, there is little interaction between these faculty, and the size of the market does not warrant publication of textbooks with adequate depth. The objective of aviation management courses should be to provide enough depth in the unique aspects of a particular field of aviation to enable the student to engage in critical analysis and problem solving in that field. In addition, the courses should be structured in a manner that allows students to integrate material and apply management skills. What is needed is a broad based organized effort to identify appropriate content for aviation management courses, and to develop activities which will meet the objectives of these courses. This paper presents a potential program to meet the first need, and two examples which illustrate the type of activities that can be used to meet the second need.
The role of verbal irony in conflict talk among relatives and friends in an Argentinian community

Abstract This article shows the role of verbal irony in conflict talk among relatives and friends. Excerpts from ten naturally occurring multiparty conversations among relatives and friends were analyzed. The analysis shows that the introduction of verbal irony in the conversation by one of the participants can: (1) end the conflict between two other participants by switching the topic of the interaction; (2) extend the conflict; (3) fail to alter the trajectory of the conflict sequence because one of the participants does not acknowledge the irony; (4) defuse a dispute about an unpleasant topic for one or two of the participants; or (5) initiate a dispute among relatives and/or friends whose relationship is not a friendly one. The analysis in this article is qualitative rather than quantitative; the tendencies presented are not based on frequency.
Identification of Electrolyte-Soluble Organic Cross-Talk Species in a Lithium-Ion Battery via a Two-Compartment Cell

Electrode cross-talk in lithium-ion batteries has been increasingly recognized in recent years as an explanation for several performance trends during cycling. However, little is known about the na...
Self-regulation to Activate the use of ICT in Context of Training by Competencies: Case Study in Competencies of Collaborative Work, Knowledge and Management of Information

Self-regulation on the part of students regarding the use or adoption of technologies is generally directed as a process of dynamic transitions between roles in life, the environment, globalization and ICTs. The objective of this study was to provide a framework to determine the interrelation of activation of the use of ICTs by students in the context of the evaluation of general competences through project-oriented learning. We worked with a sample of 93 students. An experimental design of random sampling was used. In the analysis of results, the degree of use of ICTs according to the convergence model is demonstrated [1]. Consequently, self-regulation training facilitates students to use strategies related to reflective learning in their own personal work environment and collaborative network work environment.
The SETD6 Methyltransferase Plays an Essential Role in Hippocampus-Dependent Memory Formation

Abstract Background Epigenetic mechanisms are critical for hippocampus-dependent memory formation. Building on previous studies that implicate the N-lysine methyltransferase SETD6 in the activation of nuclear factor-κB RELA (also known as transcription factor p65) as an epigenetic recruiter, we hypothesized that SETD6 is a key player in the epigenetic control of long-term memory. Methods Using a series of molecular, biochemical, imaging, electrophysiological, and behavioral experiments, we interrogated the effects of short interfering RNA–mediated knockdown of Setd6 in the rat dorsal hippocampus during memory consolidation. Results Our findings demonstrate that SETD6 is necessary for memory-related nuclear factor-κB RELA methylation at lysine 310 and associated increases in H3K9me2 (histone H3 lysine 9 dimethylation) in the dorsal hippocampus and that SETD6 knockdown interferes with memory consolidation, alters gene expression patterns, and disrupts spine morphology. Conclusions Together, these findings suggest that SETD6 plays a critical role in memory formation and may act as an upstream initiator of H3K9me2 changes in the hippocampus during memory consolidation.
Eco-efficient design indices for reinforced concrete members

The production of cement, the primary binder in concrete, is resulting in notable environmental impacts worldwide. It has been argued that efficient use of cement in concrete and the efficient design of concrete components can be a means for reducing the impacts from these materials by lowering overall demand. In systems where concrete is the only material used, efficient design can often be related to requisite material properties; however, the concept of efficient use becomes more complex in multi-material systems, such as steel reinforced concrete. In this work, steps towards developing engineered methods for efficient design of reinforced concrete members are taken by developing equations to relate environmental impacts to the volume of concrete and volume of steel required. This work focuses on mitigation of greenhouse gas (GHG) emissions, but the equations developed can be extended to other environmental impacts as well. The results indicate that different member designs require different concrete mixtures and reinforcement cross-sectional areas to reduce GHG emissions; driving down cement content may not be the sole parameter for reducing GHG emissions from concrete.
Nitrate and Phosphate Transporters Rescue Fluoride Toxicity in Yeast.

Organisms are exposed to fluoride in the air, water, and soil. Yeast and other microbes utilize fluoride channels as a method to prevent intracellular fluoride accumulation and mediate fluoride tox...
Brief, Intensive, and Concentrated Treatment of Specific Phobia in a Child With Minimally Verbal Autism Spectrum Disorder:

This case study illustrates a brief, intensive, cognitive behavioral therapy (CBT) for a young male client with a specific phobia of dogs and comorbid autism spectrum disorder (ASD). CBT has been s...
The Diterpenoid Lactone Andrographolide (ANDRO) Stimulates Autophagy and Induces Reactive Oxygen Species (ROS)-Dependent Apoptosis in Lymphoma Cell Lines

ANDRO is a diterpenoid lactone isolated from Andrographis paniculata (King of Bitters), an important herbal medicine used in China. It has been reported to have anti-inflammatory, anti-hypertensive, anti-viral and immunostimulant properties. It has also been shown to inhibit cancer cell proliferation and induce apoptosis in HL-60 (leukemia), PC-3 (prostatic adenocarcinoma), MDA-MB-231 (breast cancer), HepG2 (liver cancer), HeLa (cervical cancer) and HCT116 (colorectal cancer) cell lines. The diterpenoids have been found to generate ROS and may increase apoptosis by altering the cellular redox state. We hypothesized that ANDRO would lead to cell death in lymphoma cell lines and that the effect may be related to altered cellular redox state. We studied the Burkitt p53 mutated Ramos cell line, the mantle cell lymphoma line Granta and L428, a resistant EBV-negative Hodgkin lymphoma cell line. We found that after incubation with increasing concentrations of ANDRO, there was dose and time-dependent cell death as measured by MTT. The IC50 (concentration that achieved 50% cell proliferation inhibition) at 48h was 20μM for Ramos, 40μM for Granta, and 50μM for L428. ROS was measured by oxidation of 2’7’dichlorofluorescein diacetate (DCFDA) to dichlorofluorescein (DCF) and analyzed by fluorescence-activated cell sorting (FACS) following incubation at 1hour (h), 2h, 3h, 5h, 38h, and 48h with ANDRO (20–80μM). ANDRO increased ROS production in all lymphoma cell lines, which was abrogated by the antioxidant N-acetyl-L-cysteine (NAC). Maximum ROS generation with ANDRO was seen at 48h for Ramos (1.7 fold), 5h for Granta (1.6 fold), and 38h for L428 (2.4 fold). To determine the mechanism of cell death, we measured apoptosis by Annexin-V/propidium iodide (PI), and detected by flow cytometry (FACS). Cells were treated with ANDRO in the presence or absence of the reduced glutathione (GSH) depleting agent buthionine sulfoximine (BSO) (100μM) for 28h, 48h, and 72h. We found that the AC50 (concentration that achieved 50% apoptosis) was 40μM for Ramos at 72h, 40μM for Granta at 48h and >80μM for L428 at 48h, while in the presence of BSO it was 60% Annexin-V+/PI+) in malignant B-cells from a patient with chronic lymphocytic leukemia/small lymphocytic lymphoma (trisomy 12, peripheral blood absolute lymphocyte count 95.2 K/uL, bulky adenopathy) very low concentrations (5μM at 18h) in vitro, which was also reversible with NAC. We conclude that ANDRO induces ROS-dependent apoptosis in lymphoma cell lines and in a primary tumor sample, which is enhanced by depletion of GSH and inhibited by the antioxidant NAC. These effects appear to proceed through caspase activation and inhibition of autophagy, and are in part dependent on signaling through forkhead transcription factors and altered cellular redox pathways. Further studies of diterpenoids as single agents or in combination with other anti-lymphoma agents are warranted.
GPS spoofing detection for the power grid network using a multireceiver hierarchical framework architecture

In the future, the modernized power grid, or smart grid, will utilize devices called phasor measurement units (PMUs) to continuously monitor the power grid state in real time. These devices utilize GPS to synchronize the voltage and current phasor measurements across the continental network; however, because the civilian GPS signals are unencrypted, PMUs are susceptible to GPS spoofing attacks. We propose a spoofing detection algorithm using a wide-area, hierarchical architecture. In the network, each PMU transmits conditioned signal fragments containing the military P(Y) signal, which serves as an encrypted signature in the background of all authentic GPS signals. This signature is then verified among a subnetwork consisting of a select number of well-dispersed receivers. We subsequently compare representative signals generated for each subnetwork in order to detect coordinated attacks against the subnetwork receiver collection. Using real-world data recorded during a government-sponsored, live-sky spoofing event, we demonstrate that our algorithm successfully evaluates the authenticity of a widely dispersed receiver network.
Detection and Classification of UAVs Using RF Fingerprints in the Presence of Wi-Fi and Bluetooth Interference

This paper investigates the problem of detection and classification of unmanned aerial vehicles (UAVs) in the presence of wireless interference signals using a passive radio frequency (RF) surveillance system. The system uses a multistage detector to distinguish signals transmitted by a UAV controller from the background noise and interference signals. First, RF signals from any source are detected using a Markov models-based naive Bayes decision mechanism. When the receiver operates at a signal-to-noise ratio (SNR) of 10 dB, and the threshold, which defines the states of the models, is set at a level 3.5 times the standard deviation of the preprocessed noise data, a detection accuracy of 99.8% with a false alarm rate of 2.8% is achieved. Second, signals from Wi-Fi and Bluetooth emitters, if present, are detected based on the bandwidth and modulation features of the detected RF signal. Once the input signal is identified as a UAV controller signal, it is classified using machine learning (ML) techniques. Fifteen statistical features extracted from the energy transients of the UAV controller signals are fed to neighborhood component analysis (NCA), and the three most significant features are selected. The performance of the NCA and five different ML classifiers are studied for 15 different types of UAV controllers. A classification accuracy of 98.13% is achieved by k-nearest neighbor classifier at 25 dB SNR. Classification performance is also investigated at different SNR levels and for a set of 17 UAV controllers which includes two pairs from the same UAV controller models.
Natural History and Consequences of Nonunion in Mandibular and Maxillary Free Flaps

ObjectiveTo describe the natural history of bone segment union in head and neck free flap procedures and detail the association of poor segment union with postoperative complications.Study DesignCa...
Frequency and Characteristics of First-Time Palliative Care Referrals During the Last Day of Life.

Abstract Context Palliative care referrals (PCRs) improve symptom management, provide psychosocial and spiritual support, clarify goals of care, and facilitate discharge planning. However, very late PCR can result in increased clinician distress and prevent patients and families from benefiting from the full spectrum of interdisciplinary care. Objectives To determine the frequency and predictors of PCR within 24 hours of death. Methods Consecutive first-time inpatient PCR from September 1, 2013 to August 31, 2017 was identified to determine the frequency and predictors of referrals within 24 hours of death. We compared the clinical characteristics with a random sample of patients discharged alive or died more than 24 hours after first-time PCR as a control, stratified by year of consult in a 1:1 ratio. Results Of 7322 first-time PCRs, 154 (2%) died within 24 hours of referral. These patients were older (P = 0.003) and had higher scores for depression (P = 0.0009), drowsiness (P = 0.02), and shortness of breath (P = 0.008) compared with a random sample of 153 patients discharged alive or died more than 24 hours after first-time PCR. Patients who received a PCR within 24 hours of death were more likely than the control group to have Eastern Cooperative Oncology Group 4 (95% vs. 25%, P Conclusion Although only a small proportion of first-time PCR occurred in the last 24 hours of life, the patients had a significant amount of distress, indicating a missed opportunity for timely palliative care intervention. These sentinel events call for specific guidelines to better support patients, families, and clinicians during this difficult time. Further research is needed to understand how to minimize very late PCR.
Medicolegal Considerations Regarding Steroid Use in Otolaryngology: A Review of the Literature.

Objective:To review the literature on corticosteroid use and provide recommendations on patient counseling and/or consent to promote judicious prescribing and reduce the incidence of corticosteroid...
The effect of disease and treatment-related factors on biopsy results after prostate brachytherapy: implications for treatment optimization.

BACKGROUND Posttreatment prostate biopsy is a method of assessing local control after irradiation for prostate carcinoma. An analysis of the effect of disease- and treatment-related factors on biopsy results after prostate brachytherapy was performed to aid in patient selection and treatment optimization. METHODS Two hundred sixty-eight patients underwent posttreatment prostate biopsy (6–8 cores) 2 years after brachytherapy alone without external beam irradiation. Follow-up ranged from 24 to 111 months (median, 43 months). Implants were performed using a real-time ultrasound guided technique with the isotopes 125I in 186 and 103Pd in 82 patients. Ninety-eight patients underwent hormonal therapy (HT) 3 months before and 2–3 months after implant. Implant dose was defined as the D90 (dose delivered to 90% of the gland from the dose volume histogram generated using 1-month computed tomography–based dosimetry). RESULTS Overall, 89% of patients (238 of 268) had negative biopsies. A positive biopsy was a predictor of biochemical failure. Patients with a positive biopsy had a 5-year freedom from biochemical failure of 40% versus 76% for patients with a negative biopsy (P = 0.0003). Univariate and multivariate analysis found that risk group, HT, and implant dose significantly affected biopsy outcome. Patients with low risk features (prostate specific antigen [PSA] ≤ 10 ng/mL; Gleason score ≤ 6; and classification T2a or lower) (n = 104) had a negative biopsy rate of 95% versus 85% for those with high risk features (PSA > 10 ng/mL or Gleason score ≥ 7 or classification T2b or higher) (n = 164) (P = 0.008). Hormonal therapy was associated with a negative biopsy rate of 98% versus 84% for implant alone (P = 0.003). Patients receiving a high implant dose (D90 ≥ 140 grays [Gy] for 125I or ≥ 100 Gy for 103Pd) (n = 174) had a negative biopsy rate of 95% versus 77% for those receiving a low dose (D90 < 140 Gy for 125I or < 100 Gy for 103Pd) (n = 87; P < 0.001). CONCLUSIONS Biopsy results support the use of brachytherapy without external beam irradiation for patients with low risk features and highlight the importance of achieving an adequate implant dose. Cancer 2000;89:1829–34. © 2000 American Cancer Society.
Let's start talking

* Let's Start Talking is a workbook-style textbook that focuses on oral communication. The text provides a variety of topics, useful for teenagers or adults at a high-beginning/low-intermediate level. Its goal is active conversation in class, in both small and large groups. The text incorporates all four skills to achieve the goal of effective conversation. Each of the 20 chapters presents a specific theme to develop conversational skills. The themes, such as budgeting, traveling, and choosing a university, contain skills that are directly applicable for students in an ESL setting in the United States. Conversation focuses on specific tasks related to the theme. Each topic presents informal conversation and insights into U.S. culture. Although the format varies, each chapter consists of six parts: Vocabulary, Read and Consider, Pre-Discussion, Decide and Write, Discussion, and Extend. At the beginning of each chapter, the text presents target vocabulary encapsulating the theme along with a wealth of common expressions useful for student discussion. Read and Consider gives a concise statement of the situation under discussion, easily grasped by the students. The Pre-Discussion phase introduces model phrases and dialogues that lay the groundwork for conversation. This section centers on individual preparation of the task, giving students an opportunity to formulate their thoughts clearly. Ideally, this process leads to focused conversation in small groups. Using the target vocabulary and phrases practiced in the Pre-Discussion phase, the small group forms a response to the situation and shares the result in whole-class discussion. In the Discussion segment, students compare and contrast the decisions of each group, as well as individual choices. Finally, in the Extend section, students relate class material to real-life contexts outside of the classroom. The major strength of the text lies in this section, because it carries classwork to unrehearsed communication beyond the classroom. Interactive activities, such as practicing model dialogues, making decisions, writing letters, formulating conversations, and role playing, understand how g nder and e hnicity inf uence cl ssrooms and
A graph reduction approach to incremental term rewriting

Our concern is incremental term rewriting: efficient normalization of a sequence of terms that are related to one another by some set of disjoint subterm replacements. Such sequences of similar terms arise frequently in practical applications of term rewriting systems. Previous approaches to this problem [9, 10], have applied only to a limited class of reduction systems and rewriting strategies. In this paper, we present a new algorithm, \({\text{IN}}{{\text{C}}_{f\mathcal{R}}}\), for carrying out incremental term rewriting in an arbitrary left-linear term rewriting system \(\mathcal{R}\) possessing a non-parallel normalizing rewriting strategy \({f_\mathcal{R}}\). This algorithm is based on a novel variant of graph rewriting.
Rechnerintegrierte Produktionssysteme: Eine Fallstudie

In diesem Kapitel wird eine konkrete Fallstudie fur eine geregelte arbeitsteilige Anwendung vorgestellt. Die Fallstudie stammt aus dem Bereich der rechnerintegrierten Produktionssysteme als einem typischen Anwendungsbereich, bei dem Automation durch Rechnereinsatz und Rationalisierung durch Arbeitsteilung und -organisation erklarte Ziele sind. Das untersuchte Unternehmen eignet sich insofern als Fallstudie fur die in Kapitel 1 aufgezeigte Problemstellung, weil modernste Hardware- und Softwaretechnologie in die meisten Unternehmensbereiche bereits eingezogen sind und jetzt die Integration der einzelnen Bausteine als nachster Schritt im Hinblick auf ein rechnerintegriertes Produktionssystem (CIM, Computer Integrated Manufacturing) ansteht. Kernanliegen bei der Vorstellung der Fallstudie sind einerseits die Unterscheidung zwischen Ablaufsteuerung auf funktionaler Ebene und Arbeitsteiligkeit auf Datenebene und andererseits die Identifikation fehlender Mechanismen zur Unterstutzung beider Ebenen.