cssi/SciSciGPT-SciSciNet huggingface dataset:
Man of Steel Syndrome: Silicone and Mineral Oil Injections With Associated Hypercalcemia, Hypophosphatemia, and Proximal Muscle Weakness.

Silicone/mineral oil-induced granulomas have been described as an inflammatory granulomatous response when silicone/mineral oil is injected for cosmetic purposes. These sclerosing granulomas can lead to hypercalcemia. Here we present a 33-year-old man with hypercalcemia, hypophosphatemia, progressively worsening fatigue, severe proximal muscle weakness, and depression. He had an athletic build with increased muscle bulk and several areas of indurated, nontender, firm, well-circumscribed lesions in the subcutaneous tissue of his anterior pectoralis, triceps, and biceps bilaterally because of injecting himself with silicone/mineral oil-based product into his muscles. Sclerosing granulomas were diagnosed on the MRI. He had extremely low or undetectable serum levels of 25-hydroxyvitamin D [25(OH)D], and persistently elevated serum levels of 1,25-dihydroxyvitamin D [1,25(OH)2D] and calcium. He developed hypophosphatemia associated with elevated levels of fibroblast growth factor 23 (FGF-23) and severe proximal muscle weakness. Treatment with systemic steroids, furosemide, calcitonin, ketoconazole, and denosumab resulted in a significant decrease in his serum calcium, but with minimal impact on his hypophosphatemia and fatigue.Correcting his severe vitamin D deficiency with small doses of vitamin D and raising his blood level of 25(OH)D from undetectable to 10 ng/mL without significantly affecting his serum calcium or phosphate was effective in reversing his severe proximal muscle weakness, permitting him to lift his head and to be free of his wheelchair. Although measurement of the 1,25(OH)2D level is not mandatory in all cases of hypercalcemia, it is indicated in a patient who has low serum PTH levels. Clinicians need to be aware that vitamin D deficiency can cause severe proximal muscle weakness such that the patient is unable to lift his head from his chest or ambulate. This may lead to a psychiatric disorder misdiagnosis. © 2019 The Authors. JBMR Plus is published by Wiley Periodicals, Inc. on behalf of the American Society for Bone and Mineral Research.
Biologically Plausible Ferroelectric Quasi-Leaky Integrate and Fire Neuron

Biologically plausible mechanism like homeostasis compliments Hebbian learning to allow unsupervised learning in spiking neural networks [1]. In this work, we propose a novel ferroelectric-based quasi-LIF neuron that induces intrinsic homeostasis. We experimentally characterize and perform phase-field simulations to delineate the non-trivial transient polarization relaxation mechanism associated with multi-domain interaction in poly-crystalline ferroelectric, such as Zr doped $\text{HfO}_{2}$ , that underlines the Q-LIF behavior. Network level simulations with the Q-LIF neuron model exhibits a 2.3x reduction in firing rate compared to traditional LIF neuron while maintaining iso-accuracy of 84-85% across varying network sizes. Such an energy-efficient hardware for spiking neuron can enable ultra-low power data processing in energy constrained environments suitable for edge-intelligence.
Adjoint-based particle defect yield modeling for silicon photonics

Integrated silicon photonics offers great potential for monolithic integrated photonic and electronic components using existing integrated circuit fabrication infrastructure. However, understanding of the impact of IC process variations on performance of photonic components remains limited. Methods for analysis that identify sensitivity of photonic components to the variety of process variations encountered during fabrication are crucial to enable viable design and manufacturing of silicon photonic systems. We present the application of the adjoint method to predict the impact of different types of particle defects on silicon photonic circuits. The adjoint method is applied for both component and circuit level analysis to reduce computational cost, and shows good consistency with direct simulations. The results for complicated device components and small circuits are shown and discussed. The model and results can be used to help generate layout design rules and critical area extraction methods, and to assist silicon photonics designers in predicting and optimizing yield of complex silicon photonics devices and circuits.
Efficient Convolutional Neural Networks for Multi-Spectral Image Classification

While a great deal of research has been directed towards developing neural network architectures for RGB images, there is a relative dearth of research directed towards developing neural network architectures specifically for multi-spectral and hyper-spectral imagery. We have adapted recent developments in small efficient convolutional neural networks (CNNs), to create a small CNN architecture capable of being trained from scratch to classify 10 band multi-spectral images, using much fewer parameters than popular deep architectures, such as the ResNet or DenseNet architectures. We show that this network provides higher classification accuracy and greater sample efficiency than the same network using RGB images. Further, using a Bayesian version of our CNN architecture we show that a network that is capable of working with multi-spectral imagery significantly reduces the uncertainty associated with class predictions compared to using RGB images.
Putting Technology in Its Place: Design Thinking’s Social Technology at Work:

Design thinking can be a critical facilitator of new technologies, but it is also a technology in its own right—a social technology that encourages more productive innovation conversations that are...
Characterizing the frequency of modifiable histological changes observed on surveillance biopsies in pediatric kidney allograft recipients.

Rejection is responsible for just under 50% of graft loss in the pediatric kidney transplant population. Early identification and treatment of allograft injury, specifically modifiable pathologies such as subclinical rejection (SCR), calcineurin inhibitor toxicity, and BK virus nephropathy, may improve allograft survival. Protocol surveillance biopsy (SB) currently offers the earliest opportunity for targeted interventions. This is a single-center retrospective review of 215 kidney SBs obtained from 2008 to 2016 in 97 pediatric kidney transplant recipients. SBs were obtained at 6, 12, and 24 months post-transplantation. Frequency of abnormal histologic findings, estimated glomerular filtration rate at time of SB, and SB-related complications were recorded. Data were analyzed to investigate possible time trends and the presence of demographic or clinical associations with abnormal histologic findings. Potentially modifiable histologic findings were seen in 38.1% of all SBs. SCR was found with increasing frequency across all time points with an estimated 49% increase in the odds of a SCR finding per additional 6 months post-transplantation (aOR 1.49, 95% CI 1.06–2.09, p = 0.022). Among follow-up biopsies in patients who underwent treatment for SCR, 50% had no SCR and 18.8% showed histologic improvement. The complication rate associated with SB was 1.9% (4/215 SBs) and consisted of only minor complications. SBs are safe and offer the opportunity to identify and treat modifiable histologic changes in the pediatric kidney transplant population. The performance of SBs for up to 2 years after transplantation can have meaningful clinical impact.
Ecos de la Cueva de Montesinos en un cuento urbano colombiano Echoes of the Cave of Montesinos in a Colombian Urban Story

El presente estudio explora y explica la correspondencia directa entre dos textos separados por el tiempo. El primero, un episodio legendario que aparece en la segunda parte del Quijote (1615), que ha sido copiosamente analizado. El segundo, un cuento perteneciente a la literatura colombiana contemporanea, que a traves de un proceso de palimpsesto evoca al primero. Siguiendo la teoria de Gerard Genette, el episodio de la novela de Cervantes funciona como el hipotexto del cuento contemporaneo (hipertexto) y entre ellos se articula una dimension compartida que presenta similitudes y a la vez, contrasta epocas, espacios y cosmovisiones dentro de una pluralidad de voces superpuestas. El autor colombiano Pablo Garcia Dussan utiliza, en cierta medida, parte de la tecnica narrativa usada por Cervantes y de esta manera establece un juego de espejos y doble realidades que brindan como resultado un texto bidimensional. Sin duda, un analisis comprensivo del hipertexto (cuento contemporaneo), remitira a la lectura del capitulo correspondiente de la novela de Cervantes. El enfasis de esta investigacion esta en la historia urbana que muestra claras afinidades con el episodio de la novela del autor espanol. The present article explores and explains the direct correlation between two texts separated by time. The first, a legendary episode that appears in the second part of Don Quixote (1615) that has been widely analyzed. The second, a story belonging to contemporary Colombian literature, which through a palimpsest process evokes the first. Following the theory of Gerard Genette, the episode of Cervantes’s novel serves as the hypotext of the contemporary story (hypertext). In both works, there exists a textual relationship which keeps similarities but also contrasts time periods, spaces and worldviews within a plurality of overlapping voices. The Colombian author Pablo Garcia Dussan employs, to some extent, part of the narrative technique used by Cervantes and thus establishes a set of mirrors and double realities that result in a two-dimensional text. Undoubtedly, a comprehensive analysis of the hypertext (contemporary story) will refer to the reading of the corresponding chapter of Cervantes's novel. The emphasis of this research is on the urban story that shows clear affinities with the episode of the novel by the Spanish author.
Low Cobalamin Levels as Predictors of Cobalamin Deficiency: Importance of Comorbidities Associated with Increased Oxidative Stress

Abstract Background Cobalamin (B12) deficiency can lead to irreversible neurocognitive changes if unrecognized. Screening involves measurement of serum cobalamin levels, but the sensitive metabolic indicators of cobalamin deficiency, methylmalonic acid (MMA) and homocysteine (HCys), may be normal when cobalamin values are low and elevated when cobalamin values are normal . Because cobalamin is inactivated by oxidation, the relationship between these metabolites and comorbidities associated with increased oxidative stress (oxidant risks) in subjects with low and low-normal cobalamin levels was studied. Methods A retrospective record-review was conducted of community-dwelling adults evaluated for cobalamin deficiency during a 12-year period with serum cobalamin values in the low (≤ 200 pg/mL; n = 49) or low-normal (201-300 pg/mL; n = 187) range and concurrent measurement of MMA. Results When "No" oxidant risk was present, elevated MMA (>250 nmol/L) and HCys (>12.1 μmol/L) values occurred in 50% and 30% of subjects, respectively ( P P ≤.012). Pharmacologic doses of cyanocobalamin significantly decreased metabolite values in ≥ 94% of treated subjects. Conclusion In subjects with low or low-normal cobalamin values, metabolic evidence of cobalamin deficiency is more frequent when 3 or more oxidant risks are present. Thus, defining a low serum cobalamin level to screen for cobalamin deficiency may be a "moving target" due to the variable presence and severity of often subtle, confounding clinical conditions in individual subjects.
Treatment of HBeAg‐negative chronic hepatitis B patients with nucleos(t)ide analogues

Current agents used in the treatment of chronic hepatitis B (CHB) can be classified into interferons-α (IFN-α: standard or pegylated) and nucleos(t)ide analogues (NUCs). NUCs are now used in most CHB patients for several reasons. They can be given to all CHB patients, even those with contraindications to IFN-α. NUCs are more convenient to use (one oral tablet daily) than IFN-α (subcutaneous injections) and are well tolerated with a good safety profile, while IFN-α has frequent and potentially severe side effects and worsens the patient's quality of life. All NUCs are potent anti-hepatitis B virus agents (all but adefovir are more potent than IFN-α) with entecavir(ETV) and tenofovir offering the highest potency and most importantly minimal to negligible risk of resistance during long-term monotherapy [corrected]. Prolongation of entecavir or tenofovir monotherapy maintains and slightly increases the initially high virological remission rates (67-76% of HBeAg-positive and 90-93% of HBeAg-negative patients) and this is expected to result in improved long-term outcomes. The need for long-term, perhaps indefinite, treatment is the main limitation of NUCs and the finite duration (48 weeks) the main advantage of IFN-α. However, only a minority of IFN-α-treated patients achieve durable sustained off-treatment responses (HBeAg-positive: 30-35%, HBeAg-negative: 20-25%), while NUCs may be safely discontinued in HBeAg-positive patients with stable HBeAg seroconversion. Because there will always be concerns for safety and family planning issues with long-term therapy, NUCs should be used judiciously and should not be prescribed in young CHB patients with mild liver disease.
Phenolic constituents of ELM wood

Abstract Two new 2-naphthoic acid derivatives have been isolated from the aqueous extract of the heartwood of Ulmus thomasii Sarg. They have been shown to be 6-hydroxy-5,7-dimethoxy-2-naphthoic acid (I) and 6-hydroxy-3-hydroxymethyl-5,7-dimethoxy-2-naphthoic acid lactone (IV). The NMR spectra of several related naphthols and naphthoic acids and their derivatives have been examined. Acetylation of naphthol derivatives produces a characteristic downfield shift of naphthalene protons ortho to OH groups in their NMR spectra.
Activity of a phage-modified RNA polymerase at hybrid promoters: Effects of substituting thymine for hydroxymethyluracil in a phage SP01 middle promoter

Abstract Transcription of bacteriophage SP01 middle promoters is specifically initiated by a complex of the Bacillus subtilis host's RNA polymerase core (E) with the SP01 gene 28 transcription-regulating protein, gp28. Normal SP01 DNA contains hydroxymethyluracil (hmUra) in place of thymine and E.gp28 preferentially transcribes hmUra-containing DNA. Hybrid DNA molecules containing an SP01 middle promoter, PM25.1, have been constructed in which one DNA strand contains T and the other hmUra. The major feature of these reciprocal hybrid promoters is that one has, predominantly, T substituted for hmUra in the central −35 recognition sequence in the transcribed strand, while the other has, predominantly, T substituted for hmUra in the −10 recognition sequence in the non-transcribed strand. Binding by the E.gp28 RNA polymerase and transcription of these hybrid promoters and of the normal, all-hmUra, promoter have been compared. Both hybrid promoters are weaker than the normal PM25.1 promoter, but the hybrid promoter with T substituted in the −10 sequence is the weakest of the set. The DNase I footprint of the normal PM25.1 promoter shows temperature-dependent protection of a relatively long stretch of DNA downstream from the transcriptional start site, correlating with a thermal transition of transcriptional activity of promoter complexes. The stronger of the hybrid promoters also undergoes this transition, but the weaker does not. We discuss these findings in terms of protein-DNA interactions determining specificity for a modified nucleotide at this promoter.
Holistic Designs for Field Instruction in the Contemporary Social Work Curriculum

Abstract This article addresses the issue of the field education component in a holistic curriculum. It presents two designs for field instruction that were introduced in a university-based laboratory setting. The integration of field practice with the content of the holistic academic practice curriculum of the school was a primary objective of these designs. The first design emerged out of a holistic/multi-method assignment and the second was derived from a holistic/generalist orientation applied to a problem area or population. Issues in field teaching using these approaches are reviewed and guidelines for the field instructor are suggested.
Dewey’s Debt to Barnes

John Dewey’s association with Albert C. Barnes significantly influenced his monumental Art as Experience, a fact Dewey fully acknowledged both in that work and in other writings. Yet Barnes’s contribution to Dewey’s ideas has seldom been discussed. Even those who write about Dewey’s aesthetics frequently ignore it, or provide distorted descriptions of Barnes’s life and of the two men’s relationship. Dewey was drawn to dynamic individuals who provided empirical evidence for his philosophical views. Barnes’s passion for education, conviction that looking at visual art could transform lives, and faith in action all influenced Dewey’s thinking. An examination of the Dewey-Barnes correspondence and of some of their joint activities helps set the historical record straight about Dewey’s debt to Barnes. It also contributes to our understanding of both men’s aesthetic theories and is particularly relevant as the Barnes Foundation moves to a more public venue in Philadelphia in 2012.
Neutrinos, Dark Matter and Nuclear Detection

Solutions to problems in nuclear non-proliferation and counter- terrorism may be found at the forefront of modern physics. Neutrino oscil- lation experiments, dark matter searches, and high energy astrophysics, are based on technology advances that have may also have application to nuclear detection. The detection problems share many characteristics, including energy scales, time structures, particle-type, and, of course, the combination of high backgrounds and low signal levels. This convergence of basic and applied physics is realized in non-proliferation and homeland security projects at Lawrence Livermore National Laboratory. Examples described here include reactor anti-neutrino monitoring, dual-phase noble liquid TPC development, gamma-ray telescopes, and nuclear resonance fluorescence.
Operating characteristics of a high pressure "wire" hollow cathode plasmas

Summary form only given. In this work, a "wire" hollow cathode device was designed using the "pd" constraints, where p is the pressure, d is the gap distance between the electrodes, and was operated in a wide pressure range from 10 mbar to several 100s of mbar. The plasma is generated in this device by a set of thin tungsten wires forming the hollow cathode geometry. The design allows to generate plasma between the individual wires at high pressures, and in the volume enclosed by the wires at lower pressures. The two anodes are located axially at the end of the dielectric cylindrical disk holding the cathode electrodes. The enclosure of the electrode assembly is a cylindrical quartz tube allowing the transmission of the UV radiation from the device. The two end-windows are used for optical diagnosis to investigate the radial distribution of the species by radial mapping of the excitation region in the device.
Soil Dynamics Following Fire in Juncus and Spartina Marshes

We examined soil changes in the O-5 and 5-15 cm layers for one year after a fire in burned Juncus roemerianus and Spartina bakeri marshes and an unburned Juncus marsh. Each marsh was sampled (N = 25) preburn, immediately postburn, and 1, 3, 6, 9, and 12 months postburn. All marshes were flooded at the time of the fire; water levels declined below the surface by 6 months but reflooded at 12 months after the fire. Soil samples were analyzed for pH, conductivity, organic matter, exchangeable Ca, Mg, and K, available PO4-P, total Kjeldahl nitrogen (TKN), exchangeable NO3-N, NO2-N, and NH4-N. Changes due to burning were most pronounced in the surface (0-5 cm) layer. Soil pH increased 0.16-0.28 units immediately postburn but returned to preburn levels in 1 month. Organic matter increased by 1 month and remained elevated through 9 months after the fire. Calcium, Mg, K, and PO4-P all increased by 1 month after burning, and the increases persisted for 6 to 12 months. Conductivity increased in association with these cations. Burning released ions from organic matter as indicated by the increase in pH, conductivity, Ca, Mg, K, and PO4-P. NH4-N in burned marshes was elevated 6 months and NO3-N 12 months after burning. TKN showed seasonal variations but no clear fire-related changes. Nitrogen species were affected by the seasonally varying water levels as well as fire; these changes differed from those observed in many upland systems.
Ti:Al2O3 Laser Pumped by a Frequency Doubled Nd:YAG Laser

A Ti:Al2O3 laser was developed that was capable of producing 5.1 mJ of output with a slope efficiency of 0.3. The primary limitation to this laser was caused by the relatively large loss in the Ti:Al2O3 crystal at the lasing wavelength, about 0.16 cm-1. This high loss both caused the high threshold and limited the slope efficiency. The laser was characterized by measuring the laser output and the pulse length as a function of the energy input. The former measurement was also done as a function of the output mirror reflectivity. From this data, the slope efficiency and the threshold of the laser was determined as a function of the mirror reflectivity.
Single-stranded structures are present within plasmids containing the Epstein-Barr virus latent origin of replication.

Abstract The Epstein-Barr virus (EBV) latent origin of plasmid replication (oriP) contains two essential regions, a family of repeats with 20 imperfect copies of a 30-bp sequence and a dyad symmetry element with four similar 30-bp repeats. Each of the repeats has an internal palindromic sequence and can bind EBNA 1, a protein that together with oriP constitutes the only viral element necessary for EBV maintenance and replication. Using single-strand-specific nucleases, we have probed plasmids containing oriP-derived sequences for the presence of secondary structural elements. Multiple single-stranded structures were detected within the oriP region. Of the two essential elements of oriP, the family of repeats seemed to extrude these structures at a much higher frequency than did sequences within the dyad symmetry region. Though negative supercoiling was found to stabilize the single-stranded structures, they showed significant stability even after linearization of the oriP plasmids. Two major single-stranded structures detected involved approximately 12 bp of DNA. These loci could be transiently unwound regions that form because of negative supercoiling and the high A + T content of this region of DNA, or they could be cruciform structures extruded within the palindromic sequences of oriP that may be important sites for protein-DNA interactions in the EBV oriP.
BiCMOS ASIC for high performance systems

The advantages of BiCMOS technology are discussed and illustrated by comparing the delay of BiCMOS and CMOS gates. High-speed fully static conditional-sum addition (CSA) logic adders designed using a 1-b CSA adder, a two-to-one multiplexer, and a BiCMOS inverter are described. The high drive capability of BICMOS minimizes the speed and area penalties that occur in longer word-length CSA adders using CMOS buffers. The significant performance improvement of BiCMOS over CMOS for dense-memory designs (especially in the word-line driver and sense-amp sections) is also discussed. The speed and high drive capability of BiCMOS logic is well suited to reducing the word-line delay, which can constitute 50-60% of the access time delay of large memory designs. Access time of memory blocks is also reduced by using bipolar sensing. The BiCMOS sense amp provides the ability to quickly sense small transitions on highly capacitive bit lines within large memory arrays. A 64-tap fixed coefficient FIR (finite impulse response) digital filter for a video image application designed using this gate array is examined. >
New Results on the Performance of a Protocol for Adaptive Modulation and Coding

Adaptive transmission protocols are required for efficient communications in packet radio systems that must transmit over time-varying wireless channels. We present a protocol that employs simple receiver statistics for adapting the error-control code and modulation format from packet to packet in response to changes in the channel's propagation loss, such as those caused by fading and shadowing.
Teach to Reach: Addressing Lesbian, Gay, Bisexual, and Transgender Youth Issues in the Classroom

This article explores the delicate and complex issues immediate to the lives of lesbian, gay, bisexual, and transgender (LGBT) youth. The author places the discussion within the context of learning environments and presents ways in which pre-service and in-service teachers can help create safe and equitable spaces for all learners. Presented are various classroom strategies, activities, and resources for educators to tap into and utilize.
337 A COMPARISON OF THE PHARMACOKINETICS OF NETILMICIN AND GENTAMICIN IN NEWBORNS

In a prospective double-blind randomized study, 20 newborn infants were given either NT or GT IV 5mg/kg/day, q 12h for presumed septicemia. After at least 4 doses of aminoglycoside antibiotic, serum samples were drawn prior to and 0.5, 2, 4, 8, and 12 hours after infusion. (Antibiotic concentrations in sera were determined by microbioassay). The following were determined for each drug: t½=half life, kel=rate of elimination, Vp=apparent volume of central compartment Cpo=theoretical concentration of aminoglycoside in plasma at t=0. There were no statistically significant differences in serum values at any time (see graph) or in pharmacokinetic parameters (see table.) Our data indicate that the pharmacokinetics of netilmicin and gentamicin in the newborn are comparable.
Coordination of prehensile forces during precision grip in Huntington's disease

The present study examined the coordination of prehensile forces during precision grip in subjects with Huntington's disease (HD). Fingertip forces were measured in 12 subjects with HD and 12 age-matched controls during the lifting of an instrumented object whose weight and surface texture were varied. The results indicate that subjects with HD have impaired initiation and delayed transitions between movement sequences and produce excessive and variable forces. However, subjects with HD demonstrated anticipatory scaling of force development based on the object's expected physical properties (planning) and adjustment of the force to the object's actual physical properties (sensorimotor integration). The observed findings generally were unrelated to the overall disease severity. However, the variability in forces was correlated with functional capacity and motor performance suggesting that variability is a key feature of the motor deficit. These results provide insights into the impaired hand function observed in individuals with HD.
The Separation Of State And Local Revenues...

I. The advantages claimed for the plan of separation, 438. — II. First criticism: separation would not necessarily ensure a just distribution of state taxation, 441. — Second criticism: separation would not necessarily lead to a full valuation of property subject to local taxation, 446. — Third criticism: separation would not end diversity of local interests in tax legislation, 449. — Fourth criticism: local option in taxation is undesirable, 451. — Fifth criticism: it is undesirable to abolish direct state taxation, 453. — III. Conclusion, 456.
COMPLEX DYNAMICS IN A MODIFIED MACARTHUR–ROSENZWEIG MODEL WITH PREDATOR PARING

In this work we propose an ecological model, which is a modified version of the Bazykin model. This model of predator–prey interaction emphasizes predator pairing that yields steady state, periodic and extinction stable solutions. Moreover, we find attractor coexistence between limit cycles, steady states, and the extinction solution, which is always a stable attractor. We also study this model as a spatially extended system in one and two dimensions and obtain Turing patterns such as stripes and spots as well as the so-called black-eye patterns, and, as in the homogeneous case, the spatial patterns coexist with the homogeneous extinction solution.
Quantum Theory and Special Relativity

IN NATURE of Mar. 2 a communication by Prof. Wiener and myself was published directing attention to the urgent need of a more thorough harmonisation of quantum theory and relativity than is found in Dirac's theory of the electron. It was further pointed out that the latter can be formally carried over into Einstein's unified theory of electricity and gravitation by making use of distant parallelism and interpreting the operators p0, P1, P2, P3, of Dirac's theory as a differentiation along the Cartesian axes of the local quadruples, which themselves need not be integrable. Since then this suggestion has been discussed more fully and independently by E. Wigner (Zeit. fur Phys., 53, 592; 1929), and by I. Tamm (Kon. Ak. van Wet. te Amsterdam, 32, 288; 1929). Now the Dirac theory is an attempt to reconcile the demands of the transformation theory of quantum mechanics, which alone is consistent with the observed dualism of particle and wave as Heisenberg and Dirac have shown, with the requirements of special relativity. Hence it would appear that a unified theory of matter, electricity, and gravitation is possible along these general lines.
Faisabilité et fiabilité de la cœliochirurgie dans les cancers utérins chez les patientes de poids normal

Resume Objectifs Evaluer la faisabilite et la fiabilite de la cœlioscopie dans la prise en charge therapeutique des cancers uterins (cancer de l’endometre [CE] et du col uterin au stade precoce [CCUP]) chez les patientes presentant un IMC ≤ 30 kg/m 2 , dans un service d’oncologie gynecologique favorisant la cœliochirurgie. Patientes et methodes Il s’agit d’une etude descriptive monocentrique retrospective realisee entre janvier 2003 et mai 2011 a l’institut Claudius-Regaud, centre de lutte contre le cancer, Midi-Pyrenees. Depuis 2003, une politique privilegiant la cœlioscopie en premiere intention a ete mise en place. Resultats Deux cent trois patientes ont ete analysees, dont 85 atteintes d’un CCUP, et 118 d’un CE. Elle rapporte une fiabilite elevee de la cœlioscopie s’elevant respectivement pour le CE, et le CCUP a des valeurs de l’ordre de 98,8 %, avec une faisabilite de 80,1 % et 97,6 % chez les patientes non obeses. Le taux de laparoconversion etait de 1,2 % et de 3,1 %, et le taux de complications peroperatoires de 5,9 % et 7,4 %. Les complications postoperatoires de grade ≥ 3 selon la classification de « Memorial secondary events grading system » etait de 3 (3,5 %) pour le CCUP et 3 (2,5 %) pour le CE. Discussion et conclusion Cette etude retrouve une fiabilite et une faisabilite elevees de la cœlioscopie dans la prise en charge des cancers uterins chez les patientes non obeses. La concurrence de la chirurgie robot-assistee ne peut donc s’envisager que chez les patientes obeses. Elle ne dispense pas de la formation a la chirurgie endoscopique avancee.
Recombination in plasma-deposited amorphous Si:H. Luminescence decay

An investigation of the photoluminescence decay in plasma-deposited amorphous Si: H is presented. The relative contribution of radiative and nonradiative transitions are shown in undoped samples with efficiencies varying over two orders of magnitude. In high-efficiency samples the 10-K radiative rate spans nearly six orders of magnitude, and is interpreted as radiative tunneling of band-tail electrons and holes. A systematic shift of time-resolved spectra by 0.15 eV to low energy is related to the width of the band tails. The decay is found to be excitation-intensity-dependent when the electron-hole pair density exceeds about 1.5\ifmmode\times\else\texttimes\fi{}${10}^{18}$ ${\mathrm{cm}}^{\ensuremath{-}3}$. This result is explained by overlap between neighboring pairs, and we deduce that the radius of the larger carrier is 11 \AA{}\ifmmode\pm\else\textpm\fi{}20%. A decrease of the radiative transition rate as the temperature increases is seen as evidence of carrier diffusion and is believed to explain a corresponding increase in the luminescence intensity. From this and other evidence it is argued that the electron-phonon coupling observed in the luminescence is associated with hole states, while electrons are not strongly coupled. We suggest that self-trapped hole states are split off from the top of the valence band, and account for the ${E}_{y}$ band in the field-effect density of states.
Modulation of cortical and pyramidal tract induced motor responses by electrical stimulation of the basal ganglia.

Two general mechanisms based on anatomical studies are possible for modulation of motor activity by the caudate nucleus and globus pallidus. These mechanisms are: (1) modulation of the output of cortical neurons that exert motor influences; and (2) modulation of subcortical neurons that exert motor influences. Differentiation between these two mechanisms was accomplished in the present study by two experimental approaches, both of which employed the conditioning-test paradigm. The first approach was an investigation of caudate nucleus or globus pallidus modulation (conditioning stimulus) of flexor responses of the anterior tibialis muscle elicited by electrical stimulation of the sensorimotor cortex (test stimulus) or pyramidal tract (test stimulus). These investigations were carried out in the intact and in decorticate cats. The second approach was an analysis of modulation of cortically induced pyramidal tract responses (direct and indirect, D-I potentials) by conditioning shock trains delivered to various loci within the caudate nucleus or globus pallidus. Both approaches were designed to determine which inhibitory and facilitatory motor influences of the basal ganglia occured at a cortical or subcortical level. Simultaneous stimulation of a locus within the caudate nucleus and the sensorimotor cortex evoked either an enhancement, reduction or no alteration of the cortically induced increase in flexor responses (measured by Ia afferent activity, EMG, myogram). In contrast, no inhibitory influences occurred from caudate nucleus stimulation upon pyramidal tract induced flexor responses in either the intact or decorticate preparation. Inhibitory loci were distributed toward the rostral portion of the caudate nucleus, whereas facilitatory loci were distributed throughout; this distribution was statistally sigificant (X2; P < 0.01). Only enhancement or no influence upon cortical induced or pyramidal tract induced responses were obtained by conditioning stimuli to the globus pallidus. In the unanesthetized but immobilized cat, trains of shocks delivered to the caudate nucleus enhanced, reduced or had no influence upon the cortically evoked direct (D) and indirect (I) potentials recorded in the bulbar pyramidal tract. The distribution of facilitatory and inhibitory loci was organized in a similar fashion as in the anesthetized preparation. From these observations, a model was proposed in which the output of the caudate nucleus exerts both facilitatory or inhibitory modulation of the tonically active globus pallidus cells. The latter in turn predominantly or exclusively facilitate output of pyramidal tract neurons as well as the output of subcortical structures; both effects facilitate motor responses at the spinal level.
Public expenditures in sub-Saharan Africa during a period of economic reforms

Abstract Public expenditure restraint is the most direct means of reducing balance-of-payments and budget deficits, and is consequently a key aspect of macroeconomic adjustment programs. The results of this study indicate a steady increase in total central government and social services spending during 1977–1989 in sub-Saharan Africa. The growth in population, however, contributed to an overall erosion in per capita expenditures. While total government expenditures as a share of GDP have been stable during the past decade, they have declined net of interest repayments, which represent an increasingly large share of total spending. An analysis of spending in the three years before and after donor-financed adjustment programs began reveals no pattern of increase or decrease in real levels of total and social sector expenditures, or in social sector spending as a share of the total expenditures. Elasticities of health and education spending with respect to GDP were found to be greater than unity in recent years, indicating that as countries develop, social spending will constitute a larger share of GDP.
Nutrient-use efficiency of woody plants on contrasting soils in the western Great Basin, Nevada

Soils that develop on areas of hydrothermally altered rock in the western Great Basin of Nevada support Sierran conifers, such as Pinus ponderosa, in a desert climate. These soils have low pH (°3.7) and low concentrations of HCO3——extractable P (5.6 mg/g), compared to adjacent brown desert soils supporting sagebrush (Artemisia tridentata) vegetation. The occurrence of Sierran conifers appears to be related to their tolerance of the unusual soil chemistry, high nutrient—use efficiency in growth, high reabsorption of foliar nutrients before leaf abscission, and slow growth rates. Most of these traits appear to be inherent characteristics of evergreen vegetation, and show little acclimation to the nutrient—poor conditions on hydrothermally altered rock. In contrast, plants of the Great Basin sagebrush vegetation are physiologically intolerant of the unusually soils that develop from hydrothermally altered rock and are excluded from such sites. See full-text article at JSTOR
Mumford's Metaphors: Sticks and Stones versus Ships and the Sea

In Sticks and Stones (1924), a critical account of the sources and prospects of American architecture, Lewis Mumford argues that when “the economic basis of provincial life shifted from the farm to the sea … [it] broke up the internal unity of the village.” His argument is augmented by metaphors: the instabilities of wind, sea, and ship are opposed to the virtues of “good building” and “rooted dignity.” The stable earth and the village architecture it supports are portrayed as organically superior to the chaotic fluidity of the sea. Mumford's metaphors and rhetorical skill bolster a historical narrative that continues to influence prevalent notions of “tradition” in American architecture. Nevertheless, the sea metaphors he deprecates are vital to exemplify American architecture, art, and literature.
Hydrogen-assisted ductile fracture in porous iron

Abstract The present paper has studied the effect of porosity and hydrogen on the deformation and fracture properties in porous iron using double notched specimen tests and quantitative metallography analyses to characterize void growth. The presence of hydrogen produced the greatest hardening effect in the sample with a porosity of 0.037. It was found that while the effect of hydrogen on the reduction in area was greatest in the specimen with a porosity of 0.037, its effect on the fracture energy did not depend on the porosity. The ductile fracture surface morphology remained the same in all the specimens without and with hydrogen except for the sample with porosity of 0.003 where hydrogen induced some quasi-cleavage fracture. The quantitative metallography analysis of voids in the region near the fracture surface and below the unfractured notch has demonstrated that hydrogen causes the void growth to increase prior to plastic instability. The effect of hydrogen on the void growth was found to be slightly enhanced as the porosity was increased. The microscopic process of hardening induced by hydrogen is presented. The mechanism for hydrogen-assisted void growth is discussed in light of a recently developed model using a dislocation theory.
Hecke-Rogers, Andrews identities; combinatorial proofs

Abstract An involution on the set of pairs of partitions of integers into distinct parts is given which proves an identity of Hecke–Rogers. A bijection shows equivalence with an identity of Andrews.
Ischemic necrosis of the cecum: Findings in three dialysis patients

Three patients with chronic renal failure on maintenance hemodialysis who developed ischemic necrosis of the cecum of the nonocclusive type are presented. Clinical and laboratory findings were compatible with acute appendicitis, but at surgery the cecum was ischemic in each case. Follow up for 1 to 15 years showed no recurrence. Factors that predispose to this condition include: aging, anatomical characteristics of the colon's vasculature, decreased blood supply to the intestine secondary to fluid shifts during hemodialysis, spasm without occlusion caused by vasoactive endogenous substances as well as drugs such as beta blockers and digoxin, and possibly bioincompatibility with artificial membranes. Diagnostic procedures are discussed, with angiography being still the most accurate, however, when segmental ischemia develops, exploratory laparotomy with cecal resection is indicated with good outcome.
On the structure of cluster point sets of iteratively generated sequences

LetX be a closed subset of a topological spaceF; leta(·) be a continuous map fromX intoX; let {xi} be a sequence generated iteratively bya(·) fromx0 inX, i.e.,xi+1 =a(xi),i=0, 1, 2, ...; and letQ(x0) be the cluster point set of {xi}. In this paper, we prove that, if there exists a pointz inQ(x0) such that (i)z is isolated with respect toQ(x0), (ii)z is a periodic point ofa(·) of periodp, and (iii)z possesses a sequentially compact neighborhood, then (iv)Q(x0) containsp points, (v) the sequence {xi} is contained in a sequentially compact set, and (vi) every point inQ(x0) possesses properties (i) and (ii). The application of the preceding results to the caseF=En leads to the following: (vii) ifQ(x0) contains one and only one point, then {xi} converges; (viii) ifQ(x0) contains a finite number of points, then {xi} is bounded; and (ix) ifQ(x0) containsp points, then every point inQ(x0) is a periodic point ofa(·) of periodp.
Design formulas for beam-truss gridworks

Abstract New formulae are presented for the exact elastic analysis of torsionless beam and/or truss gridworks, i.e. the common beam-beam grid and the truss-truss or double layer grid are covered as special cases. The formulae are valid for an arbitrary loading including continuous beam loads and the possibility of loads on truss joints between the gridwork nodes. Deflection and stresses between the grid nodes are given directly, in contrast to a frame analysis which requires a separate element analysis to find midspan descriptors subsequent to determining the adjacent node quantities. The solutions are in the form of finite or infinite sinusoidal series and are valid for three conditions along the rectangular or skewed boundary: (1) simple supports; (2) simple end and flexible side supports and (3) flexible end and side supports. The formulae comprise an extension of lattice field theory in two respects: (1) an exact transformation from fine to coarse lattice solutions is given to deal with truss members which have joints between the system nodes and; (2) the case of general conditions along all four boundary sides is treated rationally.
Growth hormone and glucose interrelationships in diabetes: studies with insulin infusion during continuous blood glucose analysis.

ABSTRACT To examine changes in plasma levels of human growth hormone (HGH) in severe diabetics under conditions resembling hypoglycemic reactions, 8 diabetics and 6 normal subjects were given insulin infusions at a constant rate during continuous automated blood glucose (BG) analysis. HGH was determined by radioimmunoassay at frequent intervals. All subjects tested who reached a BG nadir of 35 mg/100 ml had HGH increases. Other HGH increases occurred also during hyperglycemia in 7 tests, but only in diabetics. Mean increases in plasma HGH were similar in normals and in diabetics and whether during hypoglycemia or during hyperglycemia. No hyperglycemic or hypoglycemic effect of HGH increases was discernible. The method proved to be uniquely suited for exploring HGH and BG changes during the infusion of insulin. Diabetics differed from normals by augmenting circulating levels of HGH during hyperglycemia, whether or not BG was decreasing at the time the observations were made.
The pH Dependence of Heme Pocket Hydration and Ligand Rebinding Kinetics in Photodissociated Carbonmonoxymyoglobin

We monitored the occupancy of a functionally important non-coordinated water molecule in the distal heme pocket of sperm whale myoglobin over the pH range 4.3-9.4. Water occupancy was assessed by using time-resolved spectroscopy to detect the perturbation of the heme visible band absorption spectrum caused by water entry after CO photodissociation ( Goldbeck, R. A., Bhaskaran, S., Ortega, C., Mendoza, J. L., Olson, J. S., Soman, J., Kliger, D. S., and Esquerra, R. M. (2006) Proc. Natl. Acad. Sci. U. S. A. 103, 1254-1259 ). We found that the water occupancy observed during the time interval between ligand photolysis and diffusive recombination decreased by nearly 20% as the pH was lowered below 6. This decrease accounted for most of the concomitant increase in the observed CO bimolecular recombination rate constant, as the lower water occupancy presented a smaller kinetic barrier to CO entry into the pocket at lower pH. These results were consistent with a model in which the distal histidine, which stabilizes the water molecule within the distal pocket by accepting a hydrogen bond, tends to swing out of the pocket upon protonation and destabilize the water occupancy at low pH. Extrapolation of this model to lower pH suggests that the additional increase in ligand association rate constant observed previously in stopped-flow studies at pH 3 may also be due in part to reduced distal water occupancy concomitant with further His64 protonation and coupled protein conformational change.
Enhanced oxygen absorption into bisulphite solutions containing transition metal ion catalysts

Abstract The sulphite oxidation reaction was studied by measuring the oxygen absorption flux from a nitrogen mixture across an unbroken interface into 11 of unsparged, agitated sulfite (10–30 mM) and catalyst (0.01–100 mM Fe, Mn, Co, Cu, Cr, Ni) solution at pH 4–6 and 50°C. The catalytic action of Fe was solubility-limited at 0.01 mM at pH 5 resulting in an enhancement factor of 2.4 at all higher concentrations. Since Mn and Co do not begin to show enhancement until about 1 mM, Fe was the strongest of the three below this level. 0.05–1 mM thiosulfate was an effective inhibitor for Mn catalysed systems but degraded into inert products. Thiosulfate had much less effect on Fe catalysed oxidation. EDTA inhibited Fe catalysis at concentrations equal or above that of the Fe. Catalytic synergism was quantified for combinations of Mn with the other metals. Mn-Fe couples caused absorption fluxes of up to five times that which would be expected from separate individual catalytic contributions.