cssi/SciSciGPT-SciSciNet huggingface dataset:
Role of the adrenal cortex and the thyroid in the mobilization of nitrogen from the tissues in fasting.

THE RATE of mobilization of nitrogen from body tissues is, like most physiological processes, influenced profoundly by the concentration of circulating hormones. Of the latter, the thyroid hormone, the adrenal cortical steroids, and the anterior pituitary growth hormone appear to be of particular importance. Participation of the thyroid and the adrenal cortex in protein mobilization has been emphasized by a variety of clinical and laboratory investigations. Generally, the effects of the thyroid and adrenal cortical hormones have been assessed by measurements of the level of nitrogen excretion, and, in clinical and experimental diabetes, the quantity of glucose in the urine. Critical evaluation of the role of growth hormone in protein metabolism has awaited isolation of the growth-promoting principle in purified form. The source of the urinary nitrogen in circumstances of augmented thyroid or adrenal cortical activity has long interested investigators. This question has been related frequently to the exist...
Lithium niobate thin films on diamond/silicon substrates for surface acoustic wave filter device applications

Abstract Piezoelectricity and surface acoustic wave (SAW) propagation of a LiNbO3/diamond/silicon multilayer structure are reported for the first time. Theoretical calculations predict lithium niobate thin films on diamond/silicon substrates have both high SAW propagation velocities and high electromechanical coupling coefficients. The metal-organic decomposition (MOD) technique is used to grow lithium niobate thin films on diamond/silicon substrates. X-ray diffraction analysis shows that the lithium niobate films are polycrystalline. SAW devices are fabricated by depositing interdigital transducers (IDTs) onto the LiNbO3/diamond/silicon films. The SAW activities are observed by measuring the frequency response of the SAW device.
Antidicer RNAse activity of monocyte chemotactic protein-induced protein-1 is critical for inducing angiogenesis

Inflammatory angiogenesis involves the induction of a novel gene ZC3H12A encoding monocyte chemoattractant protein-1 (MCP-1)-induced protein-1 (MCPIP1) that has deubiquitinase and antidicer RNAse activities. If and how these enzymatic activities of MCPIP1 mediate the biological functions of MCPIP1 are unknown. Present studies with human umbilical vein endothelial cells suggest that MCPIP-induced angiogenesis is mediated via hypoxia-inducible factor (HIF-1α), vascular endothelial growth factor (VEGF), and silent information regulator (SIRT-1) induction that results in the inhibition of angiogenesis inhibitor thrombospondin-1. MCPIP1 expression inhibited the production of the antiangiogenic microRNA (miR)-20b and -34a that repress the translation of HIF-1α and SIRT-1, respectively. The RNase-dead MCPIP mutant D141N not only did not induce angiogenesis but also failed to inhibit the production of miR-20b and -34a suggesting that the antidicer RNase activity of MCPIP1 is involved in MCPIP-mediated angiogenesis. Mimetics of miR-20b and -34a inhibited MCPIP1-induced angiogenesis confirming that MCPIP1 suppresses the biogenesis of miR-20b and -34a. Furthermore, our results indicate that MCPIP expression induces nuclear translocation of HIF-1α. We show that under hypoxia angiogenesis is mediated via induction of MCPIP1 and under normoxia, in vitro, MCPIP deubiquitinates ubiquitinated HIF-1α and the stabilized HIF-1α enters the nucleus to promote the transcription of its target genes, cyclooxygenase-2 and VEGF, suggesting that the deubiquitinase activity of MCPIP may also promote angiogenesis. The present results show for the first time that the antidicer RNase activity of MCPIP1 is critical in mediating a biological function of MCPIP, namely angiogenesis.
Transperineal repair of complex rectourethral fistula using gracilis muscle flap interposition--can urinary and bowel functions be preserved?

Purpose: Rectourethral fistula developing after prostate cancer treatment is usually complex and difficult to repair. We present our experience with 25 cases of complex rectourethral fistula using gracilis muscle interposition, addressing the efficacy of this technique as well as the postoperative urinary and fecal outcome.Materials and Methods: After receiving institutional review board approval we performed a retrospective chart review of patients with prostate cancer who had undergone gracilis muscle interposition for complex rectourethral fistula. A 1-page questionnaire was then mailed to all patients to assess urinary and bowel function.Results: At mean followup of 28 months all patients had successful fistula closure with no recurrence. Of the 18 patients (72%) with urinary continence 5 were continent after artificial urinary sphincter implantation. Three patients (12%) were totally incontinent and lost to followup. Four patients (16%) had permanent urinary diversion due to a devastated urinary outl...
Risk Factors for Antepartum and Intrapartum Stillbirth

Data from married women who participated in the 1980 National Natality Survey and the National Fetal Mortality Survey were used for a case-control study of antepartum and intrapartum stillbirth. Risk factors were identified by comparing antepartum deaths and intrapartum deaths to livebirths in separate logistic regression analyses. Risk of antepartum death was increased among black mothers, those having their first delivery, those aged 35 years or more, and those with less education. Smoking cigarettes was associated with increased risk. For intrapartum deaths, total abstention from alcohol during pregnancy was associated with increased risk in the best-fitting logistic model, as was first delivery. Body mass index was logit-linear in both models, with lower body mass index associated with lower risk. While some of these factors have already been associated with stillbirth, others have not; the new associations may reflect the continuum of loss over the gestational period, bias in the study, or clues to mechanisms by which the risk of death, before or during parturition, is increased.
Language mapping using high gamma electrocorticography, fMRI, and TMS versus electrocortical stimulation

Abstract Objective The aim of the present study was to compare localization of the language cortex using cortical stimulation mapping (CSM), high gamma electrocorticography (hgECoG), functional magnetic resonance imaging (fMRI), and transcranial magnetic stimulation (TMS). Methods Language mapping using CSM, hgECoG, fMRI, and TMS were compared in nine patients with epilepsy. Considering CSM as reference, we compared language mapping approaches based on hgECoG, fMRI, and TMS using their sensitivity, specificity, and the results of receiver operating characteristic (ROC) analyses. Results Our results show that areas involved in language processing can be identified by hgECoG, fMRI, and TMS. The average sensitivity/specificity of hgECoG, fMRI, and TMS across all patients was 100%/85%, 50%/80%, and 67%/66%, respectively. The average area under the ROC curve of hgECoG, fMRI, and TMS across CSM-positive patients was 0.98, 0.76, and 0.68, respectively. Conclusions There is considerable concordance between CSM, hgECoG, fMRI, and TMS language mapping. Our results reveal that hgECoG, fMRI, and TMS are valuable tools for presurgical language mapping. Significance Language mapping on the basis of hgECoG, fMRI, and TMS can provide important additional information, therefore, these methods can be used in conjunction with CSM or as an alternative, when the latter is deemed impractical.
Clinical, epidemiologic and microbiologic features of a persistent outbreak of amikacin-resistant Serratia marcescens.

This article describes a prolonged outbreak (January 1977 to February 1980) of amikacin-resistant Serratia marcescens (ARSM) urinary infections and the methods used for its control. Significant factors predisposing to ARSM urinary tract infection included an extended hospital stay, being in the urology ward, and undergoing urologie surgery. There had been no prior administration of amikacin or of other aminoglycosides in 20 of 27 patients with ARSM urinary tract infections. Chronically infected patients who required multiple hospitalizations represented a major reservoir for the perpetuation of the outbreak, overshadowing the importance of aminoglycoside use. Traditional control measures and even a major change in the inanimate environment were only partially effective in controlling the outbreak, but treatment of bacteriuric patients in the urology unit with “second and third generation” cephalosporins interrupted patient-to-patient transmission. No new cases of ARSM bacteriuria appeared in the urology unit in the ensuing 12 months [Infect Control 1981; 2(5):367-372.]
Fractal regional myocardial blood flows pattern according to metabolism, not vascular anatomy

Regional myocardial blood flows are markedly heterogeneous. Fractal analysis shows strong near-neighbor correlation. In experiments to distinguish control by vascular anatomy vs. local vasomotion, coronary flows were increased in open-chest dogs by stimulating myocardial metabolism (catecholamines + atropine) with and without adenosine. During control states mean left ventricular (LV) myocardial blood flows (microspheres) were 0.5-1 ml·g(-1)·min(-1) and increased to 2-3 ml·g(-1)·min(-1) with catecholamine infusion and to ∼4 ml·g(-1)·min(-1) with adenosine (Ado). Flow heterogeneity was similar in all states: relative dispersion (RD = SD/mean) was ∼25%, using LV pieces 0.1-0.2% of total. During catecholamine infusion local flows increased in proportion to the mean flows in 45% of the LV, "tracking" closely (increased proportionately to mean flow), while ∼40% trended toward the mean. Near-neighbor regional flows remained strongly spatially correlated, with fractal dimension D near 1.2 (Hurst coefficient 0.8). The spatial patterns remain similar at varied levels of metabolic stimulation inferring metabolic dominance. In contrast, adenosine vasodilation increased flows eightfold times control while destroying correlation with the control state. The Ado-induced spatial patterns differed from control but were self-consistent, inferring that with full vasodilation the relaxed arterial anatomy dominates the distribution. We conclude that vascular anatomy governs flow distributions during adenosine vasodilation but that metabolic vasoregulation dominates in normal physiological states.
Advances in Chest Radiography Techniques: CR, DR, Tomosynthesis, and Radiation Dose Optimization

A revolution in radiography has occurred in the last three decades; digital radiography has replaced screen-film radiography. To understand digital radiography, one must begin with the fundamental principles, which have not changed since Roentgen’s time. The conversion of X-rays into a visible image, however, has changed from screen-film to digital radiography. A discussion on the characteristics of digital radiography and its most common forms, computed radiography (CR) and digital flat-panel radiography follows. The fundamentals of digital image processing are discussed, including preprocessing, latitude reduction, and contrast modification. Advanced technologies are also described, including structured phosphors, slot scanners, dual-sided CR, irradiation side sampling flat panels, and gaseous avalanche detectors. The potential application of dual energy subtraction radiography and tomosynthesis to pediatric thoracic radiography is also considered. The chapter concludes with a discussion on radiation dose optimization in pediatric chest radiography including the newest standards for exposure indicators, dose area product, dose reporting, and informatics initiatives to support dose reporting.
The Case of the Missing Laureate: The Communication Geography of the 2010 Nobel Peace Prize

The Nobel Prize ceremony for Liu Xiaobo was held on December 10, 2010, at the Oslo City Hall. The flower bedecked room was filled with some 1,000 guests, including King Harald, Queen Sonja, representatives from 46 different embassies, Chinese dissidents who had participated in the 1989 occupation of Tiananmen Square, the US Speaker of the House Nancy Pelosi, and even the Hollywood stars Denzel Washington and Anne Hathaway. Notably missing, however, was the laureate, Liu Xiaobo, who had just finished the first of year of an 11 year sentence for “inciting subversion of state power.” The laureate’s absence generated unusual dynamics of presence and absence that highlight various facets of communication geography. This chapter provides a concrete demonstration of the non-Euclidean terrain of communication using the 2010 Nobel Prize ceremony to explore the experiential continuum between space and place as it intersects the ontological paradox that communication is a container that is also contained (Adams 2009, 2011).
The Murder They Wrote: The Us Plots to Assassinate Pakistani Ambassador

The central idea of the plot was something like this: "Let's use the Pakistani criminal who has been convicted of selling fraudulent driver's licenses to immigrants. Plant him in the mosque. Tell him to act pious and be militant. But stick a wire under his shirt - to record everything he says and hears. Yes, cut his prison term if does the job.
Characterizing Charge Transfer at Water Ice Interfaces

Simulations are carried out for the ice/vapor and ice/liquid interfaces using models for water which include intermolecular charge transfer, as well as polarizability. The models transfer a small amount of charge for each hydrogen bond formed, as indicated from electronic structure calculations, from the molecule that accepts the hydrogen bond to the molecule that donates the hydrogen bond. Depending on distance from the interface, molecules can, on average, have more of one type (donor or acceptor) than the other. The asymmetric local environment leads to net charge transfer at the interface, with layers of molecules with small net charges. Molecules at the ice side of the interface tend to be positively charged, while molecules at the vapor or liquid side tend to be negatively charged.
The ODISS Project, Digital Imaging Research for Archival Institutions

AbstractIn 1985, the National Archives and Records Administration of the United States undertook the Optical Digital Image Storage System project to evaluate the feasibility and desirability of such a system to improve the preservation and reference operations for some of the institution’s more heavily used archival collections. The following year, the National Archives contracted for the development of a large-scale research system. In early 1988, the institution’s Research and Evaluation Staff will begin to scan, store, and reference a test sample of over 1.5 million documents representative of its holdings. The project will experiment with and examine all facets of the conversion operation including image enhancement capability, conversion throughput, and quality control.
Twelve years of high-resolution near-surface radiometer data provides insight into end-of-season controls in a dry grassland

Abstract. The onset of plant dormancy has proven difficult to explain in nearly all ecosystems. Most research has focused on the end-of-season dynamics of deciduous ecosystems, where leaf coloration and leaf fall are the primary phenological responses. More complex are the end-of-season dynamics of grasslands, where the mechanism of dormancy is a gradual response to climatic variables. These complications are magnified in dry grasslands, where the effects of temperature on phenology are modulated by the availability of soil water. Our objectives were to identify the primary drivers influencing the timing of end of season on the shortgrass steppe and determine if the timing of start of season, end of season, or both influences the growing season length of the shortgrass steppe. Our results suggest that temperature and soil water interact to influence the timing of end of season in the shortgrass steppe and that growing season length is strongly related to the date of start of season and less so to the date...
THE SANTEE-COOPER: A STUDY OF ESTUARINE MANIPULATIONS

Prior to 1941, the Santee had the fourth greatest discharge of any U.S. east coast river. However, with increasing demand for hydroelectric power, most of Santee's flow was diverted into the tidally dominated Cooper River. Subsequently, Charleston Harbor, South Carolina's largest port at the mouth of the Cooper, began shoaling, primarily due to deposition of riverborne silts and clays. Annual dredging expenditures now amount to approximately $5 million. To alleviate the shoaling problem, most of the Cooper River flow will be re-diverted into the Santee River within the next several years. However, rather than allowing the Santee to follow its former course, the plans call for the construction of an 18.5 km canal between the two river systems at a projected cost of $91 million. Undoubtedly, the shoaling problems in Charleston Harbor will be reduced but at the expense of deteriorating water quality due to less effective harbor flushing. The lower Santee, on the other hand, is likely to experience a return to pre-1941 conditions. Rediversion will halt the severe delta erosion but will at the same time destroy the lucrative hard clam industry and extensive seed oyster beds in the lower river. Man has over the past three and a half decades manipulated the Santee River system extensively-but was it necessary?
Reserve output link and FDL together or separately in Optical Burst Switching networks

This paper discusses burst scheduling problem in Optical Burst Switching (OBS) network with FDLs. Four burst scheduling algorithms are proposed for OBS network with FDL. To fully utilize output link and FDLs, these four algorithms schedules data bursts partially or fully according to the bursts' arriving order. The simulations results show in the OBS switch with feed-forward FDLs, reserving output link and FDL together has significantly lower data loss ratio than reserving them separately.
Sex Differences in Growth of Channeled Whelks from Buzzards Bay, Massachusetts, during One or Two Years at Liberty

AbstractWith the southern New England lobster fishery in distress, lobster fishers have focused more effort toward harvesting channeled whelks Busycotypus canaliculatus. Melongenid whelks generally grow slowly and mature late in life—characteristics that can make them vulnerable to overfishing as exploitation increases. However, minimal research has been conducted on the life history and growth rates of channeled whelks. We captured, marked, and released more than 8,700 whelks in Buzzards Bay, Massachusetts, during 2010 and 2011; 314 of the marked individuals were recovered after 1 or 2 years at liberty. Whelks that were recaptured in 2011 were measured and rereleased without determining sex, whereas whelks that were recovered in 2012 were dissected for sex determination. The unsexed animals were later classified by linear discriminant analysis using growth and morphometric variables. For both male and female whelks, growth increments decreased significantly with increasing size. Size-specific growth rate...
Matched comparison of primary versus salvage laparoscopic pyeloplasty

To compare our experience with salvage laparoscopic pyeloplasty, using a matched control set of primary laparoscopic pyeloplasty patients. We retrospectively reviewed patients who underwent laparoscopic pyeloplasty from 1996 to 2014 by a single surgeon. At least 12 months of follow-up was required. Salvage patients were matched 1:3 with primary patients. Matching was based on age ±5 years, body mass index (BMI) ±5, and type of pyeloplasty (dismembered vs. non-dismembered). Primary outcome was failure as defined as re-intervention following laparoscopic pyeloplasty (does not include temporary stenting without definitive retreatment). Of 128 laparoscopic pyeloplasty procedures, ten were salvage. These patients were matched to 26 patients who underwent a primary laparoscopic pyeloplasty in a 1:3 manner. One salvage pyeloplasty failed to match due to BMI, and the closest matches were made. Four salvage patients had one overlapping match, reducing the primary group to 26 patients. There were no differences in pre-, intra-, and postoperative variables between groups, except for operative time (salvage 247 min, primary 175 min, p = 0.03). With similar duration of radiologic and symptomatic follow-up, there was no significant difference in the rate of freedom from intervention. When matching for factors that could affect success, salvage laparoscopic pyeloplasty performed as well as primary pyeloplasty except for a longer operative time. In experienced hands, salvage laparoscopic pyeloplasty for ureteropelvic junction obstruction recurrence after prior pyeloplasty is a safe and effective procedure, and should be considered an excellent alternative to the more commonly recommended endopyelotomy.
Identifying Hearing Deficiencies from Statistically Learned Speech Features for Personalized Tuning of Cochlear Implants

Cochlear implants (CIs) are an effective intervention for individuals with severe-to-profound sensorineural hearing loss. Currently, no tuning procedure exists that can fully exploit the technology. We propose online unsupervised algorithms to learn features from the speech of a severely-to-profoundly hearing-impaired patient round-the-clock and compare the features to those learned from the normal hearing population using a set of neurophysiological metrics. Experimental results are presented. The information from comparison can be exploited to modify the signal processing in a patient’s CI to enhance his audibility of speech.
Abdominal pain – learning when not to intervene!

Epiploic appendagitis (EA) is an uncommon cause of abdominal pain. It is a benign condition but may mimic other serious causes of acute abdomen such as appendicitis, diverticulitis, and gynecological emergency in severe cases. Knowledge of this condition in the differential diagnosis of abdominal pain can save unnecessary hospital admission, antibiotics, and surgery. In this article, we present the case of a 43-year-old female who presented to our hospital with a 2-day history of right lower quadrant abdominal pain and diarrhea. She was diagnosed with EA with computed tomography of abdomen with contrast and was managed conservatively with good outcome.
Compact atom interferometer using a single laser

A laser system for a light-pulse atom interferometer typically includes a number of laser sources for cooling and for atom optics to meet different frequency detuning requirements at different stages of a measurement sequence. The number of laser units required makes the achievable minimum size and power of the instrument challenging, especially for space applications. We demonstrate a compact cesium atom interferometer operated by only a single laser. This is achieved by dynamically changing the laser output frequency while maintaining spectroscopic reference to an atomic transition. We are able to generate cold atoms and obtain atom interferometer fringes all with the same laser.
A narrative framework for forgiveness at the end of life: suggestions for future research in health communication

ABSTRACTForgiveness is a topic that is relevant and prominent in end of life conversations. However, while the process of forgiveness has become increasingly studied in health contexts by communication scholars, through various methodologies and across multiple contexts, research on forgiveness in the end of life context, particularly in the field of health communication, is lacking. Moreover, there is a need for qualitative inquiry, and I argue that as this research gap is addressed, the projects of the medical humanities and hospice can—and should—inform how health communication scholars situate and understand forgiveness at the end of life. This essay proposes an interpretive narrative approach, which grounds forgiveness within the narratives of the living and the dying, of persons and not patients.
Enzymatic biomineralization of biocompatible CuInS2, (CuInZn)S2 and CuInS2/ZnS core/shell nanocrystals for bioimaging

This work demonstrates a bioenabled fully aqueous phase and room temperature route to the synthesis of CuInS2/ZnS core/shell quantum confined nanocrystals conjugated to IgG antibodies and used for fluorescent tagging of THP-1 leukemia cells. This elegant, straightforward and green approach avoids the use of solvents, high temperatures and the necessity to phase transfer the nanocrystals prior to application. Non-toxic CuInS2, (CuInZn)S2, and CuInS2/ZnS core/shell quantum confined nanocrystals are synthesized via a biomineralization process based on a single recombinant cystathionine γ-lyase (CSE) enzyme. First, soluble In-S complexes are formed from indium acetate and H2S generated by CSE, which are then stabilized by l-cysteine in solution. The subsequent addition of copper, or both copper and zinc, precursors then results in the immediate formation of CuInS2 or (CuInZn)S2 quantum dots. Shell growth is realized through subsequent introduction of Zn acetate to the preformed core nanocrystals. The size and optical properties of the nanocrystals are tuned by adjusting the indium precursor concentration and initial incubation period. CuInS2/ZnS core/shell particles are conjugated to IgG antibodies using EDC/NHS cross-linkers and then applied in the bioimaging of THP-1 cells. Cytotoxicity tests confirm that CuInS2/ZnS core/shell quantum dots do not cause cell death during bioimaging. Thus, this biomineralization enabled approach provides a facile, low temperature route for the fully aqueous synthesis of non-toxic CuInS2/ZnS quantum dots, which are ideal for use in bioimaging applications.
Underwater Explosion Phenomena and Shock Physics

This paper presents a brief introduction to the basic fundamentals of underwater explosions, including discussion of the features of explosive charge detonation, the formation and characterization of the associated shock wave, bulk cavitation effects, gas bubble formation and dynamics, surface effects and shock wave refraction characteristics. Illustrations of each of these fundamental aspects of underwater explosion (UNDEX) loadings are made with a set of videos from a variety of experimental testing events. In addition, analyses of associated measured loading and dynamic response data, as well as descriptions of supporting numerical simulations of these events are presented. At the conclusion of this paper, each of these UNDEX effects are tied together with a summary discussion and illustration.
Analyzing Ideological Discourse on Social Media: A Case Study of the Abortion Debate

Social media provides a unique platform enabling public discourse around cross-cutting ideologies. In this paper, we provide a methodological lens for studying the discourses around the controversial topic of abortion on social media. Drawing from the theoretical framework of "Critical Discourse Analysis", we study discourse around abortion on Twitter through analysis of language and the manifested socio-cultural practices. First, employing a large dataset of over 700 thousand posts, we find that abortion discourse can be classified into three ideologies: For, Against, and Neutral to Abortion. We observe these ideological categories to be characterized by distinctive textual and psycholinguistic cues. Finally, we analyze the nature of discourse across ideologies against the backdrop of socio-cultural practices associated with abortion. Our findings reveal how the hegemonic nature of the rhetoric that has historically shaped the abortion debate in society is reconceptualized on Twitter. We discuss the role of social media as a public sphere that shapes critical discourse around controversial topics.
Nanoparticle-Based High- k Dielectric Composites: Opportunities and Challenges

The ever-increasing demands of miniaturization, increased functionality, better performance, and low cost for microelectronic products and packaging have been the driving forces for new and unique solutions in system integration such as system-on-chip (SOC) and system-in-package (SiP). Despite the high level of integration, the number of discrete passive components (resistors, capacitors, or inductors) remains very high. In a typical microelectronic product, about 80% of the electronic components are passive components which are unable to add gain or perform switching functions in circuit performance, but these surface-mounted discrete components occupy over 40% of the printed circuit/wiring board (PCB/PWB) surface area, account for up to 30% of solder joints and up to 90% of the component placements required in the manufacturing process. Embedded passives, an alternative to discrete passives, can address these issues associated with discrete parts, including substrate board space, cost, handling, assembly time and yield. Figure 7.1 schematically shows an example of realization of embedded passive technology by integrating resistor and capacitor films into the laminate substrates [1, 2].
Periodic testing of instrumentation and control systems

During normal operation, protection systems are on standby and possible failure of system components may therefore go undetected. Their ability to function as intended, should they be initiated after a long period of time, is thus questionable. For this reason, French as well as international rules require that protection systems be subjected to periodic tests. Because of the equipment available when the units in the French 900-MW(electric) series were designed, the instrumentation and control systems were equipped with manual periodic test systems. This was the case with the reactor protection system (RPS) periodic test equipment where the manual procedures relied on the manipulation of a large number of switches and push buttons. This manual test equipment has been successfully replaced on the 28 units in the French 900-MW(electric) series by the automatic tester discussed in this paper.
The Dionysiac Chronotope (Pre-1799–1799)

We begin our exploration of Holderlin’s poetry by looking at his early epistolary novel Hyperion, his attempt to write a tragic play, The Death of Empedokles, and his early epigrams (such as Sophokles). These works are complemented by reflections in essays such as On Religion and Becoming in Perishing. Nevertheless, the key to the birth of Holderlin’s poetic voice lies in his translations, already at this time, of Greek tragedy, something that is further enhanced by his rendition of several Pindaric songs. To investigate this historical experience of poetry, the chapter turns to Holderlin’s translation of (1) Sophocles’ Oedipus at Colonus, (2) various odes by Pindar, and (3) the first 24 lines of Euripides’ Bacchae. Now the power with which Holderlin confronts competing Dionyisac and monetised/visualised chronotopes, as articulated in Part I, begins to become clear.
Plasminogen activator inhibitor-1 and tenascin-C secreted by equine mesenchymal stromal cells stimulate dermal fibroblast migration in vitro and contribute to wound healing in vivo

Abstract Background Impaired cutaneous wound healing is common in humans, and treatments are often ineffective. Based on the significant emotional and economic burden of impaired wound healing, innovative therapies are needed. The potential of mesenchymal stromal cell (MSC)–secreted factors to treat cutaneous wounds is an active area of research that is in need of refinement before effective clinical trials can be initiated. The aims of the present study were to (i) study which MSC-secreted factors stimulate dermal fibroblast (DF) migration in vitro and (ii) evaluate the potential of these factors to promote wound healing in vivo. Methods To this end, MSCs were isolated from the peripheral blood of healthy horses, a physiologically relevant large animal model appropriate for translational wound-healing studies. Conditioned medium (CM) from cultured equine MSCs was analyzed using liquid chromatography-mass spectrophotometry (LC-MS/MS) to identify secreted proteins of interest. Double-stranded RNA-mediated interference (RNAi) was used to silence the genes encoding selected proteins, and the effects of CM from these transfected MSCs on migration of cultured equine DF cells in vitro and full-thickness wounds in mice were evaluated. Results We found that MSC-derived plasminogen activator inhibitor-1 (PAI-1) and tenascin-C significantly increased DF migration in vitro and improved wound healing in vivo by decreasing time to wound closure. Discussion These results suggest that in a complex wound environment, MSC-secreted factors PAI-1 and tenascin-C contribute to the positive effect of therapeutically applied MSC CM on wound healing.
Assessing the Implementation of American College of Surgeons Quality Indicators for Pancreatic Cancer Across an Integrated Health System.

PURPOSE:The American College of Surgeons (ACS) recently published quality assurance (QA) indicators for pancreatic cancer care. Implementing quality indicators in a newly formed health system may l...
Effect of layering gingiva-shade composite resin on the strength of denture base polymers

Abstract Statement of problem Acrylic resin denture base materials, fabricated with either a traditional technique or computer-aided design and computer-aided manufacturing (CAD-CAM) technique, layered with different thicknesses of gingiva-shade composite resin may affect the strength of the definitive prostheses and have not been investigated. Purpose The purpose of this in vitro study was to assess the flexural strength of acrylic resin denture base materials modified by layering different thicknesses of gingiva-shade composite resin. Material and methods Two denture acrylic resins, heat-polymerized type (Lucitone 199) and CAD-CAM prepolymerized type (AvaDent) polymethyl methacrylate (PMMA) resin, were used as the base materials. Three-millimeter–thick specimens were fabricated and prepared according to the ISO 1567 and ISO 20795-1:2013 and were used as the controls. A proprietary gingiva-shade composite resin (GRADIA gum shades) was used to replace different thicknesses (0.5 mm, 1.0 mm, and 1.5 mm) of the denture base materials, giving 4 groups for each tested material (n=16). A 3-point loading test was conducted by using a universal testing machine and a custom fixture with a crosshead speed of 5 mm/min. The maximum fracture loads were recorded, and ultimate flexural strength values were calculated. The collected data were statistically analyzed with ANOVA and the Tukey honestly significant difference (HSD) tests (α=.05). Representative fractured specimens were examined under a stereomicroscope at ×20 magnification and a scanning electron microscope to determine the interface and fracture patterns. Results The mean ±standard deviation of ultimate flexural strengths for the heat-polymerized acrylic resin specimens ranged from 94.79 ±9.89 MPa to 40.34 ±12.79 MPa, and that of the CAD-CAM prepolymerized acrylic resin ranged from 125.98 ±7.96 MPa to 64.16 ±20.77 MPa. Acrylic resin denture base materials after layering with gingiva-shade composite resin had a significantly lower mean fracture load than the controls (P Conclusions The flexural strengths of CAD-CAM prepolymerized acrylic resins were higher than those of the heat-polymerized denture acrylic resins. The flexural strengths of all 3 thicknesses of the CAD-CAM prepolymerized acrylic resins were greater than 65 MPa.
Characterization of the Ground States of BeC2 and BeC2- via Photoelectron Velocity Map Imaging Spectroscopy.

Due to their potentially unique properties, beryllium carbide materials have been the subject of many theoretical studies. However, experimental validation has been lacking due to the difficulties of working with Be. Neutral beryllium dicarbide has been predicted to have a T-shaped equilibrium structure (C2v), while previous quantum chemistry calculations for the structure of the anion had not yielded consistent results. In this study, we report photoelectron velocity map imaging spectra for the BeC2- X 2A1 → BeC2 X 1A1 transition. These data provide vibrational frequencies and the electron affinity of BeC2. Ab initio electronic structure calculations, validated against the experimental data, show that both the anion and the neutral form have C2v equilibrium geometries with polar covalent bonding between Be and the C2 subunit. Computed vibrational frequencies and the electron affinity, obtained at the CCSD(T) level of theory, were found to be in good agreement with the measurements.
Upper Extremity Surgery for Patients with Cerebral Palsy

Cerebral palsy results from an injury to the neurologic system. While the neurologic injury is static, the resultant physical manifestations are often dynamic, changing and evolving with growth and maturation. A large majority of individuals with cerebral palsy have some degree of functional impairment of one or both upper limbs. This chapter addresses the assessment and care of the upper extremities of these individuals, focusing on surgical interventions.
On the origin of Hume's philosophy in the passions

Abstract Hume's longest analysis of man's rational faculty—Book 1 of A Treatise of Human Nature 1—“concludes” with philosophy seemingly pronounced illegitimate, just before Hume then puzzlingly resumes the philosophic life. I argue that the section serves a crucial function in Hume's overall project: it guides thinkers through a series of introspections, leading them to both reconceive and reorient themselves as driven by the passion of curiosity. This oddly truth-directed passion redefines both reason's relationship to the passions and the nature of philosophy. Though reason and passion are prima facie antagonistic, I argue that the greater role Hume gives to the passions is the precondition for his subsequent justification of moral-political philosophy as oriented towards wisdom rather than merely towards pleasure. I then show how this justification for philosophy illuminates how Hume connects liberal education to liberal politics, and why his political philosophy emphasizes liberal maxims.
Genetic characterization of an aggressive optic nerve pilocytic glioma

Optic nerve glioma (ONG) is a rare, typically slow-growing WHO I grade tumor that affects the visual pathways. ONG is most commonly seen in the pediatric population, in association with neurofibromatosis type 1 syndrome. However, sporadic adult cases may also occur and may clinically behave more aggressively, despite benign histopathology. Genetic characterization of these tumors, particularly in the adult population, is lacking. A 39-year-old female presented with 1 month of progressive left-sided visual loss secondary to a enhancing mass along the left optic nerve sheath. Initial empiric management with focal radiotherapy failed to prevent tumor progression, prompting open biopsy which revealed a WHO I pilocytic astrocytoma of the optic nerve. Whole-exome sequencing of the biopsy specimen revealed somatic mutations in NF1,FGFR1 and PTPN11 that may provide actionable targets for molecularly guided therapies. Genetic characterization of ONG is lacking but is needed to guide the management of these rare but complex tumors. The genomic alterations reported in this case contributes to understanding the pathophysiology of adult sporadic ONG and may help guide future clinical prognostication and development of targeted therapies.
The Impact of Contract Law on the Economy: Less Than Meets the Eye?

We assume that contract law plays an important role in a market economy, but we may over-estimate its significance. A study of the Peruvian economy recently has been the focus of scholarly discussion in the United States. An entire symposium in the Yale Law Journal, the lead article and a lengthy comment in the Law & Society Review, and an article in Social & Legal Studies all have focused on norms and sanctions in underground or second economies. All of these articles have considered in some detail Hernando de Soto’s The Other Path. De Soto’s study of Peru has come to stand for second economies in all of Latin America, Africa and much of Asia.
UMA ABORDAGEM PARA O ESTUDO DA GEOMETRIA ESPACIAL COM ÊNFASE NO CÁLCULO DO VOLUME

O presente estudo refere-se a abordagem de conceitos de Geometria Espacial, apartir da metodologia de Investigacao Matematica, desenvolvidas com alunos doEnsino Medio do curso Tecnico em Agropecuaria. O objetivo principal foi investigaras conjecturas apresentadas ao calculo do volume de um cilindro com perspectivade articulacao a outra disciplina. Com o uso de materiais concretos os alunospuderam investigar o sentido de area e volume inerentes aos solidos geometricos ecompreender como o calculo da area e volume sao formalizados. A partir dametodologia utilizada, promover a compreensao dos calculos de volume, dandosignificado as operacoes matematicas realizadas.
Risk Factors for Patient and Caregiver

Financial abuse of the elderly is increasing. Existing literature classifies financial abuse as one of the major forms of exploitation of older adults. This chapter reviews the risks for abuse in the victim, perpetrator, and the environment. The typical victim is identified as white, elderly, frail, and cognitively impaired. Additional risks reviewed for victims include mental illness, substance abuse, social support, and fear. Perpetrator risks include financial or housing dependence, social stress, substance abuse, and mental illness. Environmental risks include attentiveness and living situations. This chapter reviews each factor in depth and suggests a team-based approach to proactively identify those most vulnerable to exploitation.
Linear orders in (ω)ω under eventual dominance

Publisher Summary This chapter discusses linear orders in (ѡ) ѡ under eventual dominance. If (ѡ) ѡ is the set of functions f : ѡ →ѡ ordered by eventual dominance, then under this ordering, (ѡ) ѡ embeds every linear ordering of power 1 . It is proved that 2 א 0 > א 1 and every linear ordering of cardinality א 0 are embeddable in (ѡ) ѡ .
In situ pathtube visualization with explorable images

In situ processing is considered to be the most plausible data analysis and visualization solution for extreme-scale simulations. Explorable images were introduced as an in situ visualization method to enable interactive exploration of scalar field data without need for access to the massive original data and a powerful computer. We present a technique for in situ generation of explorable images for the visualization of vector field data without incurring additional inter-processor communication during simulation. We demonstrate this technique for pathtube generation on a variety of large datasets. The resulting pathtube visualization succinctly captures the flow structure over the full time span of the simulation. Users may explore the vector field structure through the generated images by changing the view angle, generating block cutaways, adjusting lighting, or changing transfer functions to recolor pathtubes or provide partial transparency.
Orientation of z-pinch instabilities from an intense aurora as recorded in antiquity: South America

Summary form only given. In the first presentation we reported an analysis of a GPS database of petroglyphs recorded in the western US and British Columbia. These results indicated that a plasma flowing into the Earth's south magnetic pole produced an intense aurora seen worldwide. In this paper we report the findings of logged petroglyphs in Venezuela, Guyana, Surinam, French Guyana and northern Brazil as well as some preliminary results from 93 countries. With decreasing longitude towards the Greenwich Meridian, petroglyphs appear to take on an increasingly easterly orientation. This swing from south to east can be tracked through the eastern US and the Caribbean Islands to the petroglyph sites shown below (dots), between 0 and 8 degrees north and 51 to 62 degrees west. The morphological types of petroglyphs oriented eastwards appear to belong to instabilities much further out in the inflowing plasma. This suggests that the plasma, at least intense enough to to be seen at dawn and/or dusk, curved in from the east to flow inwards along the Earth's southern magnetic pole.
Strategic information systems and competitiveness: are firms ready for an IST-driven competitive challenge?

Abstract Strategic planning for information systems technology (IST) and its use for competitive advantage have been discussed for some time. However, such research focuses on the planning method and experience of firms that have been successful in their efforts to use IST for competitive advantage. Not much attention has been paid to less successful organizations and to what they are doing to prepare themselves for IST-driven competition. This paper presents a study conducted among small-to-medium size firms showing that a large fraction of these businesses place surprisingly little emphasis on planning for information systems (IS) and these business have a rather low level of awareness of the potential impact of IS planning on competitiveness. These results point to the fact that organizations need help in becoming more proactive in linking IS planning to their competitive strategy.
Geographic Information Systems, Evacuation Planning and Execution

Evacuation planning has for decades relied on the results derived from mathematical modeling and scenario development. While there exist many mathematical and simulation models dealing with evacuation planning most lack one or more critical components needed by the individuals or agencies responsible for removing people from harm’s way. Those critical components are real-time access to and representation of data to establish appropriate evacuation strategies. All the pieces for a real-time centralized evacuation system exist but have yet to be integrated as a single point system. The focus of this chapter is the underutilization of geographic information systems (GIS). The contribution of GIS is its capability to serve as that single point platform incorporating all the components. Further, and perhaps most importantly, the focus means to reinforce the benefits of the visual analysis capabilities of GIS technology.
Purification of a novel insulin-stimulated protein kinase from rat liver

We previously described a novel insulin-stimulated protein kinase activity that phosphorylates Kemptide (Leu-Arg-Arg-Ala-Ser-Leu-Gly) in cytosolic extracts of adipocytes (Yu, K-T., Khalaf, N., and Czech, M. P. (1987) J. Biol. Chem. 262, 16677-16685). In the present experiments, cytosolic extracts of livers from insulin-treated rats also exhibited a 30-100% increase in this Kemptide kinase activity and served as an abundant source for purification. The Kemptide kinase was purified in parallel from liver extracts of insulin-treated or control rats through five chromatographic steps and one polyethylene glycol precipitation. The chromatographic behavior of the insulin-stimulated Kemptide kinase differed significantly from the control kinase on Mono Q and heparin-Sepharose resins. The purified kinase preparations retain insulin stimulations of 2-10-fold. Analysis of the purified control and insulin-stimulated kinases by sodium dodecyl sulfate-polyacrylamide gel electrophoresis revealed single bands with similar silver staining intensity and apparent molecular masses of 52 kDa. The insulin-stimulated Kemptide phosphorylating activity also coincided with the major silver-stained band following isoelectric focusing in polyacrylamide gels. The stimulation of kinase activity in response to administration of insulin is due to an increase in Vmax, whereas the Km for Kemptide (0.3 mM) is unchanged. The apparent molecular mass of the native kinase determined by gel filtration is approximately 50 kDa, suggesting that it exists as a monomer. Either Mg2+ or Mn2+ serve as cofactors for the kinase which phosphorylates a variety of basic substrates including a number of peptides and histones. The activity of the Kemptide kinase is not changed by several compounds that have been shown to modulate other kinases. Based on these data, we conclude 1) a novel insulin-sensitive Kemptide kinase in liver cytosol has been purified to near homogeneity, and 2) insulin administration acutely modulates the specific activity of this Kemptide kinase in livers of intact rats.