cssi/SciSciGPT-SciSciNet huggingface dataset:
Effect of pH and oxalate on hydroquinone-derived hydroxyl radical formation during brown rot wood degradation.

The redox cycle of 2,5-dimethoxybenzoquinone (2,5-DMBQ) is proposed as a source of reducing equivalent for the regeneration of Fe2+ and H2O2 in brown rot fungal decay of wood. Oxalate has also been proposed to be the physiological iron reductant. We characterized the effect of pH and oxalate on the 2,5-DMBQ-driven Fenton chemistry and on Fe3+ reduction and oxidation. Hydroxyl radical formation was assessed by lipid peroxidation. We found that hydroquinone (2,5-DMHQ) is very stable in the absence of iron at pH 2 to 4, the pH of degraded wood. 2,5-DMHQ readily reduces Fe3+ at a rate constant of 4.5 × 103 M−1s−1 at pH 4.0. Fe2+ is also very stable at a low pH. H2O2 generation results from the autoxidation of the semiquinone radical and was observed only when 2,5-DMHQ was incubated with Fe3+. Consistent with this conclusion, lipid peroxidation occurred only in incubation mixtures containing both 2,5-DMHQ and Fe3+. Catalase and hydroxyl radical scavengers were effective inhibitors of lipid peroxidation, whereas superoxide dismutase caused no inhibition. At a low concentration of oxalate (50 μM), ferric ion reduction and lipid peroxidation are enhanced. Thus, the enhancement of both ferric ion reduction and lipid peroxidation may be due to oxalate increasing the solubility of the ferric ion. Increasing the oxalate concentration such that the oxalate/ferric ion ratio favored formation of the 2:1 and 3:1 complexes resulted in inhibition of iron reduction and lipid peroxidation. Our results confirm that hydroxyl radical formation occurs via the 2,5-DMBQ redox cycle.
INDUCTION AND MAINTENANCE OF SWALLOWING RESPONSES IN INFANTS WITH DYSPHAGIA

A treatment package was used to induce and maintain swallowing with three infants who did not swallow food or liquid. Prior to treatment, they received all nutrition and hydration via gastrostomy tube feedings. The treatment package consisted of least-to-most intrusive physical prompts, an eliciting stimulus, contingent social reinforcement, and repeated trials to induce and maintain swallowing. The design combined elements of reversal and changing criterion designs for all three infants. The package was applied across feeding devices (nipple, cup, spoon), situations (liquid, pureed foods), and persons (trainer, primary nurses, mothers). The number of swallows or ounces per feeding (from 0 to 8 ounces) and the number of feeding sessions per day (from one to five) were progressively increased. In each case, the infant received baseline conditions alternated with the treatment package. Follow-up probes were done at 15 months, 21 months, or 24 months, respectively, after the last phase for the three patients. The package was successful in that the gastrostomy tube was no longer needed for Patients 1 and 3. Patient 2 maintained functional swallowing responses but received supplemental gastrostomy feedings because of unrelated medical problems. Results are discussed in terms of the need to isolate components of the package. The package can be used in cases in which the preexisting treatments (reinforcement with preferred foods, force-feeding) are not feasible because of age, physical fragility, or the lack of a swallowing response following the presentation of food.
Computer Generation Of Images The Multi-Purpose Tool

Simulated images have been used for training for at least thirty years. This has included simulation of visual scenes and of displays from various sensor systems such as radar, sonar, infrared, and television cameras. Techniques used have included scale models, acoustic tanks, and photography. Increasingly through the years, analog and digital computation equipment has been used along with these techniques for control and modification of results. In the early sixties, the increasing power of digital computation and data processing circuitry led to consideration of systems in which the "environment" hills, targets, buildings, etc. exists only as stored numbers, and images are generated in real time by appropriate computations performed on these numbers. Such approaches promised many advantages as compared with traditional techniques. Continuous effort has been applied since that time to develop algorithms, overcome disadvantages, improve performance, and reduce cost. The results: extremely realistic systems are now in operation. Recent radar simulation systems are based on computed displays. Visual scene simulation is proving itself on several operating systems. These have been combined in correlated multi-mode displays. Development is under way to apply this technology to simulation of displays from other sensors.© (1975) COPYRIGHT SPIE--The International Society for Optical Engineering. Downloading of the abstract is permitted for personal use only.
A reinvestigation of the structures of acomonine, iliensine, 14-dehydroiliensine, and 14-benzoyliliensine

Abstract The novel structures assigned by Yunusov et al to the C19-diterpenoid alkaloids, acomonine ( 1 ), iliensine ( 2 ), 14-dehydroiliensine ( 3 ), and 14-bensoyliliensine ( 4 ) have been found to be in error. We have demonstrated that these alkaloids are identical with the well-known alkaloids, delsoline ( 5 ), delcosine ( 6 ), 14-dehydrodeloosine ( 7 ), and 14-benzoyldelcosine ( 8 ), respectively.
A Jewish Life of Jesus

Jesus Of Nazareth. His Times, His Life, And His Teachings. By Joseph Klausner, Jerusalem, 1922. The author of this Life of Jesus is a well-known scholar, who has written much, especially in Hebrew periodicals such as “Ha-Shiloh,” of which he became editor in 1903. To Christian scholars he is best known by “Die Messianischen Vorstellungen des judischen Volkes im Zeitalter der Tannaiten” (Berlin, 1904), a work distinguished to its advantage from the ordinary literature on the subject by the limitation of its field to a definite period, the first two centuries of the Christian era, and to sources recognized as authoritative. In that volume he showed himself amply acquainted with the modern Christian literature on Jewish messianic beliefs and expectations. In his Life of Jesus the same familiarity with New Testament criticism and discussion, down to the most recent, and with writings that deal at large or incidentally with the life and teaching of Jesus, appears on every page. It is, as he says, the first time that a Jewish scholar, writing in Hebrew and primarily for Jewish readers, has attempted to present the life of Jesus in the light of historical criticism and with the methods of the modern historian; previous lives of Jesus in Hebrew having been written either for the purpose of converting Jews to Christianity or of combating this propaganda.
Nasal tip bossae in rhinoplasty. Etiology, predisposing factors, and management techniques.

Objectives To identify preoperative risk factors and surgical techniques that influence the risk of developing postoperative nasal tip bossae in rhinoplasty. A secondary objective was to review the characteristics, management techniques, and outcomes of those study patients with postoperative bossae. Design Univariate and multivariate analysis carried out in a case series. Setting Private facial plastic surgery practice. Patients All patients who underwent aesthetic nasal surgery that included surgical modification of the nasal tip, and in whom documentation was complete and photographic follow-up was available, were considered eligible. The study group consisted of 875 patients of whom 37 (4.2%) developed bossae postoperatively. Main Outcome Measures Potential risk factors for postoperative bossae included age, sex, previous nasal surgery, preoperative tip asymmetry, preoperative lobular bifidity, preoperative bossae, skin thickness, surgical tip technique, use of columellar struts, columellar battens, lobular crushed cartilage grafts, and tip shield grafts. Results In the univariate analysis, females, patients undergoing primary rhinoplasty, younger age groups (12- to 22-year-olds), thin skin, and widened interdomal distance (bifidity) were all noted to have moderate or strong associations with nasal tip bossae. In the multivariate analysis, the younger age group, thin skin, and bifidity were statistically significant and independently associated with nasal tip bossae, independent of the type of tip surgery. In addition, clinically relevant associations were noted in females and patients undergoing primary rhinoplasty. Recognition of risk factors, preventive measures, and treatment methods is recommended.
Impacts of Increased Atmospheric CO2 on the Hydroclimate of theWestern United States

Abstract Regional-scale projections of climate change signals due to increases in atmospheric CO2 are generated for the western United States using a regional climate model (RCM) nested within two global scenarios from a GCM. The downscaled control climate improved the local accuracy of the GCM results substantially. The downscaled control climate is reasonably close to the results of an 8-yr regional climate hindcast using the same RCM nested within the NCEP–NCAR reanalysis, despite wet biases in high-elevation regions along the Pacific coast. The downscaled near-surface temperature signal ranges from 3 to 5 K in the western United States. The projected warming signals generally increase with increasing elevation, consistent with earlier studies for the Swiss Alps and the northwestern United States. In addition to the snow–albedo feedback, seasonal variations of the low-level flow and soil moisture appear to play important roles in the spatial pattern of warming signals. Projected changes in precipitatio...
Questionable Correlates For Automobile Shopping Behavior

This is a three-fold reply to an earlier article in the JOURNAL OF MARKETING dealing with automobile shopping behavior.The present author feels that there was a failure to consider the type of meas...
Assessing the likelihood of contaminating natural populations of bacteria with chimeric plasmids.

Some experimental approaches used to assess the contamination risk for plasmid-cloning vectors in Escherichia coli hosts are reviewed, and the problems of interpreting their results are considered. A procedure utilizing mathematical models of the contamination process and the combined results of in vivo and in vitro experiments is suggested as a way of circumventing the limitations of purely empirical risk assessment studies. For illustration of this approach, a specific mathematical model is considered, and a protocol for estimating its parameters is presented. The limitations of this model and the parameter estimation procedure are discussed.
Abstract 998: KLF4 interacts with β-catenin/TCF4 and blocks p300/CBP recruitment by β-catenin

Proceedings: AACR 101st Annual Meeting 2010‐‐ Apr 17‐21, 2010; Washington, DC Wnt signaling is crucial in the organization and maintenance of the human intestinal epithelium, and somatic mutations that result in deregulated Wnt signaling are an early event in the development of colorectal cancer. The Wnt ligand ultimately results in the stabilization of cytoplasmic β-catenin, which is then free to enter the nucleus and activate transcription through its interaction with the transcription factor TCF4. Our laboratory recently found that KLF4, a transcription factor highly expressed in the adult intestine and critical for intestinal differentiation, interacts with β-catenin and inhibits Wnt signaling. In this study, we characterize the molecular mechanisms of KLF4-mediated inhibition of Wnt/β-catenin signaling. We find that the KLF4 directly interacts with the C-terminal transactivation domain of β-catenin and inhibits p300/CBP recruitment by β-catenin. KLF4 inhibits p300/CBP-mediated β-catenin acetylation as well as histone acetylation on Wnt target genes. In addition, we observe that KLF4 directly interacts with TCF4 independently of β-catenin, and that KLF4 and TCF4 are expressed in similar patterns within the large intestine, with greatest staining near the epithelial surface. These results provide a deeper understanding of the regulation of β-catenin in the intestine, and will have important implications in cancer and stem cell research. Citation Format: {Authors}. {Abstract title} [abstract]. In: Proceedings of the 101st Annual Meeting of the American Association for Cancer Research; 2010 Apr 17-21; Washington, DC. Philadelphia (PA): AACR; Cancer Res 2010;70(8 Suppl):Abstract nr 998.
Development of electrolysis experiment system by small-scale ion-exchange membrane

A set of electrolysis experiment system based on the characteristics of wind power has been developed.The system has realized automation control by PLC,and its operating performance is good,the electrodes can be replaced easily,the eletrolysis solution can be sampled in either cathode area or anodic area conveniently,the amount of hydrogen and chlorine evolution can be metered accurately,and the system can also be applied to study the changes of cathodes,anodes and ion-exchange membrane and etc.It can guide the large scale industry application of non-synchronization wind power in edible brine eletrolysis by ion-exchange membrane.
DC pulse defibrillation.

Discussion and summary 1. In 23 cases of congenital and acquired heart disease, internal DC pulse defibrillation, with the use of a critically dampened wave form, was effective at settings between 15 and 50 watt seconds in children and adults, respectively. 2. The first such defibrillation in a human being was on Dec. 7, 1961. 3. The DC pulse defibrillator, internally, expends one half to one third as much energy to defibrillate while developing forty-one times as much power as a 60-cycle defibrillator. 4. It is suggested that the superiority of this type of defibrillator will result in its eventual replacement of all 60-cycle defibrillators.
Relationship of Edentulism, Sleep Disordered Breathing and Cardiovascular Disease: NHANES, 2007-2008.

BACKGROUND Edentulism, though declining in younger adults, remains prevalent in the U.S. older adult population. Poorer health outcomes, including cardiovascular outcomes have been associated with edentulism. Sleep disorders are also common in older adults and have been associated with cardiovascular disease. The purpose of this study is to determine if edentulism is associated with cardiovascular disease when sleep disorders are included in the analyses. METHODS Data from the National Health and Nutrition Examination Survey, 2007-2008 were used in this study. Adjusted logistic regression analyses were performed with cardiovascular disease as the dependent variable and dental status (edentulism, dentate) as the key independent variable and sleep variables introduced as potential confounders. RESULTS In multivariable analyses, edentulism was independently associated with cardiovascular disease with an adjusted odds ratio of 2.15 (95% CI: 1.54, 3.00). The model included a sleep summary variable, race, sex, education, smoking status, and drinking status, physical activity, body mass index, conditions or disease count, family poverty index, and insurance status. CONCLUSIONS Edentulism was associated with cardiovascular disease independent of sleep disordered breathing.
Abstract SY18-02: Immunogenomics and precision cancer medicine

The expansion of precision cancer medicine through robust interrogation of cancer genomes at the point of care has enhanced patient stratification and treatment selection strategies in numerous cancer types. In parallel, the rise of multiple immunotherapies, such as immune checkpoint blockade, has significantly improved clinical outcomes for multiple patient populations. The intersection of clinical cancer genomics and immuno-oncology has created an opportunity to learn how the tumor and germline genomes impact immune checkpoint blockade response, and how the immune system can be leveraged with knowledge of the cancer genome to more effectively stratify patients and tailor immune-specific therapies. Here, we describe the landscape of genomic correlates of immune checkpoint blockade, and examine how emerging genomic studies of immunotherapy responders and non-responders may inform patient selection strategies for clinical trial design. Furthermore, we explore how knowledge of the cancer genome and prioritization of neoantigens that arise from somatic mutations may impact personalized cancer vaccine development. Finally, we examine emerging data on genomic resistance to immunotherapies and the implications for combination treatment strategies. Broadly, the convergence of comprehensive clinical genomics and immuno-oncology treatment strategies may inform precision medicine for immunotherapies across cancer types. Citation Format: Eliezer Van Allen. Immunogenomics and precision cancer medicine. [abstract]. In: Proceedings of the 107th Annual Meeting of the American Association for Cancer Research; 2016 Apr 16-20; New Orleans, LA. Philadelphia (PA): AACR; Cancer Res 2016;76(14 Suppl):Abstract nr SY18-02.
BK Channel Subproteome Includes Novel Mitochondrial Partners: ADP/ATP Carrier and TOM 22 Import Receptor

BK channels are large conductance voltage- and Ca2+-sensitive potassium-selective channels. A specific splice variant, BK-DEC (mitoBKCa), is targeted to mitochondria of adult cardiomyocytes. MitoBKCa activation protects the heart from ischemia and reperfusion injury. To understand its physiological relevance in the heart we characterized the mitoBKCa-associated subproteome in rat cardiomyocytes.Three strategies were implemented: 1) Pulldown of DEC-interacting cellular proteins from left ventriculocytes using recombinant GST-DEC 2) Pulldown of DEC-interacting mitochondrial proteins from isolated left ventriculocytes mitochondria using recombinant GST-DEC and 3) Immunoprecipitation of mitoBKCa-interacting mitochondrial proteins with BK monoclonal antibody and control IgG; mitochondrial proteins were purified from left ventricles. Protein composition was analyzed with 1-D-SDS-PAGE, followed by in-gel trypsinization and LC/MS/MS Mass Spectrometry. These approaches provide a detailed view of mitoBKCa associated subproteome in cardiomyocytes.We identified 516 interacting partners with mitoBKCa with a score>21, including 161 mitochondrial proteins. Gene ontology analysis of mitoBKCa-associated mitochondrial subproteome revealed mitoBKCa association with 13 distinct mitochondrial functions in the heart. For example, DEC interacts with ADP/ATP translocase 1 (AAC) (2 peptides, n=1, score=43), suggesting a role in energy balance. Additionally, DEC also associates with TOM22 (1 peptide, n=1, score=45), suggesting a BK mitochondrial import mechanism through the TOM system. We verified interactions of mitoBKCa with TOM22 and AAC by expressing BK and TOM22 or AAC in HEK and detecting their interactions with reciprocal coimmunoprecipitation. Second, we demonstrated that BK channel, TOM22 and AAC are targeted into mitochondria using cell fractionation and confocal microscope imaging. In conclusion, proteomic analysis identified a wide variety of cellular and mitochondrial proteins forming complex with mitoBKCa channels. BK association with AAC and TOM22 suggests its involvement in regulating mitochondrial energetic balance, and a TOM22 mediated mechanism for mitochondrial targeting.
Analysis of Convective Weather Impact on Pre-Departure Routing of Flights from Fort Worth Center to New York Center

In response to severe weather conditions, Traffic Managers specify flow constraints and reroutes to route air traffic around affected regions of airspace. Providing analysis and recommendations of available reroute options and associated airspace capacities would assist Traffic Managers in making more efficient decisions in response to convective weather. These recommendations can be developed by examining historical data to determine which previous reroute options were used in similar weather and traffic conditions. This paper describes the initial steps and methodology used towards this goal. The focus of this work is flights departing from Fort Worth Center destined for New York Center. Dominant routing structures used in the absence of convective weather are identified. A method to extract relevant features from the large volume of weather data available to quantify the impact of convective weather on this routing structure over a given time range is presented. Finally, a method of estimating flow rate capacity along commonly used routes during convective weather events is described. Results show that the flow rates drop exponentially as a function of the values of the proposed feature and that convective weather on the final third of the route was found to have a greater impact on the flow rate restriction than other portions of the route.
An Oil-Free Thrust Foil Bearing Facility Design, Calibration, and Operation

New testing capabilities are needed in order to foster thrust foil air bearing technology development and aid its transition into future Oil-Free gas turbines. This paper describes a new test apparatus capable of testing thrust foil air bearings up to 100 mm in diameter at speeds to 80,000 rpm and temperatures to 650 C (1200 F). Measured parameters include bearing torque, load capacity, and bearing temperatures. This data will be used for design performance evaluations and for validation of foil bearing models. Preliminary test results demonstrate that the rig is capable of testing thrust foil air bearings under a wide range of conditions which are anticipated in future Oil-Free gas turbines. Torque as a function of speed and temperature corroborates results expected from rudimentary performance models. A number of bearings were intentionally failed with no resultant damage whatsoever to the test rig. Several test conditions (specific speeds and loads) revealed undesirable axial shaft vibrations which have been attributed to the magnetic bearing control system and are under study. Based upon these preliminary results, this test rig will be a valuable tool for thrust foil bearing research, parametric studies and technology development.
Divergent Rhodium-Catalyzed Cyclization Reactions of Enoldiazoacetamides with Nitrosoarenes

The first cyclization reactions of enoldiazo compounds with nitrosoarenes have been developed. Under the catalysis of rhodium(II) octanoate, [3 + 2]-cyclization between enoldiazoacetamides and nitrosoarenes occurred through cleavages of the enol double bond and the amide bond, thus furnishing fully substituted 5-isoxazolone derivatives. Upon changing the catalyst to rhodium(II) caprolactamate, the reaction pathway switched to an unprecedented formal [5 + 1]-cyclization that provided multifunctionalized 1,3-oxazin-4-ones with near exclusivity under otherwise identical conditions. Mechanistic studies uncovered distinct catalytic activities and reaction intermediates, which plausibly rationalized the novel reactivity and catalyst-controlled chemodivergence. Furthermore, a mechanism-inspired enantioselective rhodium-catalyzed reaction of γ-substituted enoldiazoacetamide with nitrosobenzene produced highly enantioenriched heterocycle-linked trialkylamine.
Afterward: The Future of Patient-Derived Models of Cancer

Patient-tumor mouse models were first developed in 1969. There was a great flurry of research on these models in the 1970s and 1980s, including drug-response testing for patient-tumor donors. Patient-derived mouse models have had a great resurgence since the early part of the present century. However, there is still only very scattered use of the patient mouse models for directing patient therapy. The future holds promise for the use of patient mouse models, especially those that metastasize such as patient-derived orthotopic xenografts (PDOX) for patient-directed therapy. “Humanized” patient-tumor mouse models will be used for patient-directed immuno-therapy in the future. Wider application of the models will involve the use of circulating tumor cells (CTCs) and small needle biopsies to make needle models as they are easily accessible.
Biology and Chemistry of the Dynorphin Peptides

Publisher Summary This chapter describes the biology and chemistry of the dynorphin peptides. The term dynorphin peptides is used as a collective descriptor for the opioid peptide products specified by the preprodynorphin message. Synthetic dynorphin-(l–13) was coupled to thyroglobulin and used to raise antisera in rabbits. One of these proved to have very high affinity and extremely good specificity. The IC50 for displacement of 125I-labeled dynorphin-(l–13) by dynorphin-(l–13) in a radioimmunoassay was about 50 pM, so that as little as 2 fmol in a 300-μl assay tube could be measured. The predominant antibodies recognized the sequence 3–12, as demonstrated by studies with peptide truncated sequentially from either end. This recognition of a midportion epitope was fortunate because it permitted the detection of larger forms of dynorphin, extended in either direction. There was no measurable cross-reactivity with the enkephalin pentapeptides or β-endorphin. As the Pro9-Lys10 bond in neoendorphin is resistant to hydrolysis, α-neoendorphin would be expected to be the usual product. The placement of proline-9 could be regarded as a clever device for retaining lysine-10 of the Lys10-Arg11 pair, so as to confer appropriate selectivity for κ opioid receptors.
Navigating the Peer Review Process

This editorial provides insights and guidelines for publishing in The Journal of Molecular Diagnostics.
Displacement and Strain Measurement up to 1000 °C Using a Hollow Coaxial Cable Fabry-Perot Resonator.

We present a hollow coaxial cable Fabry-Perot resonator for displacement and strain measurement up to 1000 °C. By employing a novel homemade hollow coaxial cable made of stainless steel as a sensing platform, the high-temperature tolerance of the sensor is dramatically improved. A Fabry-Perot resonator is implemented on this hollow coaxial cable by introducing two highly-reflective reflectors along the cable. Based on a nested structure design, the external displacement and strain can be directly correlated to the cavity length of the resonator. By tracking the shift of the amplitude reflection spectrum of the microwave resonator, the applied displacement and strain can be determined. The displacement measurement experiment showed that the sensor could function properly up to 1000 °C. The sensor was also employed to measure the thermal strain of a steel plate during the heating process. The stability of the novel sensor was also investigated. The developed sensing platform and sensing configurations are robust, cost-effective, easy to manufacture, and can be flexibly designed for many other measurement applications in harsh high-temperature environments.
Development and Validation of the Power Imbalance in Couples Scale.

Few researchers have quantitatively explored the relationship power-HIV risk nexus in same-sex male couples. We developed and validated the Power Imbalance in Couples Scale (PICS) to measure relationship power among men in same-sex, committed relationships and its association with sexual risk behaviors. We recruited three independent and diverse samples of male couples in the greater San Francisco and New York City metropolitan areas and conducted qualitative interviews (N1 = 96) to inform item development, followed by two quantitative surveys (N2 = 341; N3 = 434) to assess the construct, predictive, convergent, and discriminant validity of the PICS. Exploratory factor analysis of the first survey's data yielded four factors-overtly controlling partner, supportive partner, conflict avoidant actor, and overtly controlling actor-that accounted for more than 50% of the shared variance among the PICS items. Confirmatory factor analysis (CFA) of the second survey's data supported these four factors: χ2(1823) = 2493.40, p < .001; CFI = .96, RMSEA = .03 and WRMR = 1.33. Strong interfactor correlations suggested the presence of a higher-order general perception of power imbalance factor; a higher-order factor CFA model was comparable in fit to the correlated lower-order factors' CFA: χ2(2) = 2.00, p = .37. Internal reliability of the PICS scale was strong: α = .94. Men perceiving greater power imbalances in their relationships had higher odds of engaging in condomless anal intercourse with outside partners of discordant or unknown HIV status (OR 1.27; 95% CI 1.01-1.60; p = .04). The PICS is an important contribution to measuring relationship power imbalance and its sequelae among male couples; it is applicable to research on relationships, sexuality, couples, and HIV prevention.
Cognitive Organization II: Blood Pressure and Blood Glucose

The research in the preceding chapter indicated that physical symptoms can be organized into higher order categories such as emotions. The symptoms, then, can work as elements or building blocks in the construction of bodily state. A perplexing finding that hinders our understanding of the cognitive organization idea is that—to this point— we have not found strong physiological correlates of specific symptoms or symptom constellations. Although it was hypothesized that the original organization of symptoms into emotional categories was based on physiological and motoric activity during times of extreme emotions, the day-to-day perception of moods or symptoms reflected an inference process.
Robust Virtual Welding Process Optimization

Abstract The finished geometry of a welded structure is greatly affected by heat-induced distortion from the welding process. This often requires correction by straightening and top-level machining to ensure manufacturing quality. Distortion is sensitive to weld sequencing and manufacturing environment. Optimal weld sequencing can significantly reduce distortion and manufacturing cost. However, an optimal weld sequence is not always intuitively obvious, especially for large structures with many welds. Virtual Fabrication Technology (VFT) is Caterpillar’s proprietary software for the simulation of welding physics via finite element analysis. Powered by the highly successful VFT platform, a combinatorial genetic algorithm based optimization approach combined with an uncertainty quantification (UQ) module for evaluating robustness has been developed at Caterpillar for weld sequence optimization (WSO). WSO has been successfully applied to more than 50 structures, resulting in the minimization of straightening operations. The combined VFT and robust WSO approach results in an accelerated manufacturing process development schedule. We will present a summary of our WSO approach and some results that demonstrate how WSO has proven to be a transformative manufacturing planning technology at Caterpillar.
Time Course of Recovery of Iatrogenic Vocal Fold Paralysis.

Objective To clarify the time course of recovery in patients with iatrogenic vocal fold paralysis. Study design Retrospective chart review. Methods Medical records for all patients with iatrogenic vocal fold paralysis over a 10-year period were reviewed to obtain demographic and clinical information, including onset of disease and recovery of vocal function. Stroboscopic exams of patients who recovered voice were reviewed blindly to assess return of vocal fold motion. Results One hundred and two patients of 114 (89%) recovered vocal function. Time to recovery could be assessed in 39 patients who did not undergo injection augmentation. The mean time to recovery was 181.8 ± 109.3 days (left: 166.4 ± 106.7 days; right: 221.8 ± 115.6 days; P value = 0.095). Patients were analyzed according to anatomical site of surgery (skull base, carotid endarterectomy, thoracic, neck and intubation); there was no significant difference in time to recovery (P value = 0.60). Twelve of the 39 patients had recovery of vocal fold motion. The mean time to vocal recovery did not differ between patients with return of motion versus no return of motion (140.6 ± 118.0 days vs. 200.1 ± 102.2 days; P value = 0.147). Conclusion Age, gender, laterality, and anatomical site of injury do not influence recovery rate in iatrogenic vocal fold paralysis. The probability of recovery decreases over time but more slowly in comparison with idiopathic vocal fold paralysis, reflecting the greater heterogeneity of injury type in the iatrogenic population. Commonly available aggregate recovery rates overstate the potential for recovery. Level of evidence 4 Laryngoscope, 129:1159-1163, 2019.
Cardiovascular Risk Factors and Dehydroepiandrosterone Sulfate Among Latinos in the Boston Puerto Rican Health Study

Low blood dehydroepiandrosterone sulfate (DHEAS) levels have strong positive associations with stroke and coronary heart disease. However, it is unclear whether DHEAS is independently associated with cardiovascular risk factors. Therefore, we examined the association between cardiovascular risk factors and DHEAS concentration among a high-risk population of Latinos (Puerto Ricans aged 45 to 75 years at baseline) in a cross-sectional analysis of the Boston Puerto Rican Health Study. Of eligible participants, 72% completed baseline interviews and provided blood samples. Complete data were available for 1355 participants. Associations between cardiovascular risk factors (age, sex, total cholesterol, high-density lipid cholesterol, triglycerides, and glucose) and log-transformed DHEAS (μg/dL) were assessed. In robust multivariable regression analyses, DHEAS was significantly inversely associated with age (β = -12.4; 95% CI: -15.2, -9.7; per 5 years), being female (vs. male) (β = -46; 95% CI: -55.3, -36.6), and plasma triglyceride concentration (β = -0.2; 95% CI: -0.3, -0.1; per 10 mg/dL) and was positively associated with total cholesterol and plasma glucose levels (β = 1.8; 95% CI: 0.6, 3 and β = 0.2; 95% CI: 0.04, 0.3, respectively, per 10 mg/dL) after adjustment for smoking, alcohol, and physical activity and for postmenopausal hormone use in women. Estimates were unchanged after adjustment for measures of chronic disease and inflammation. Women exhibited a stronger age-related decline in DHEAS and a positive association with glucose in contrast to findings among men (P interaction < 0.05). In conclusion, in this large study of Latinos with a heavy cardiovascular risk factor burden, we observed significant associations between cardiovascular disease (CVD) risk factors and DHEAS, with variations by sex. These findings improve our understanding of the role DHEAS may play in CVD etiology.
Alveolar liquid clearance in multiple nonperfused canine lung lobes

Grimme, John D., Susan M. Lane, and Michael B. Maron.Alveolar liquid clearance in multiple nonperfused canine lung lobes. J. Appl. Physiol. 82(1): 348–353, 1997.—We evaluated the ability of canine ...
OTs' Views on Physician-Assisted Suicide (PAS): A Descriptive Research Study

Date Presented 04/05/19 Physician-assisted suicide (PAS) is increasing in the health professions community and has political relevance and ethical considerations. OTs play a holistic role in patients finding meaning and joy in their lives. To do this job to an OT’s best ability, it is important to have an understanding of the process of PAS and the views of other OTs on this topic. This was a critically needed research study due to the lack of data and research on PAS from an OT's view. Primary Author and Speaker: Lauren Johnson Additional Authors and Speakers: Shelby O'Connor, Alyssa Leathers, Morgan Voorhes, Kaitlyn Higgins, Linda Scheirton
OB DEPARTMENT: American College Of Obstetricians and Gynecologists: Confusion in Medical Data, Recent Advances in Ob-Gyn Surgery Receive Attention at Meeting

Topics presents more abstracts of selected papers presented at the recent ACOG meeting. The first group appeared in the June issue, pp. 87–91.
Determination of complete chromosomal haplotypes by bulk DNA sequencing

Abstract Haplotype phase represents the collective genetic variation between homologous chromosomes and is an essential feature of non-haploid genomes. Determining the haplotype phase requires knowledge of both the genotypes at variant sites and their linkage across each chromosome. Haplotype linkage can be either inferred statistically from a genotyped population, or determined by long-range sequencing of an individual genome. However, extending haplotype inference to the whole-chromosome scale remains challenging and usually requires special experimental techniques. Here we describe a general computational strategy to determine complete chromosomal haplotypes using a combination of bulk long-range sequencing and Hi-C sequencing. We demonstrate that this strategy can resolve the haplotypes of parental chromosomes in diploid human genomes at high precision (99%) and completeness (98%), and is further able to assemble the syntenic organization of aneuploid genomes (“digital karyotype”).
"I can't breathe": A call for antiracist nursing practice.

Abstract The killing of George Floyd by a police officer in Minneapolis, Minnesota during the Coronavirus disease 2019 pandemic brought the effects of structural racism on Black Americans into focus. Black Americans are dying from Coronavirus disease 2019 at a higher rate, and are also more likely to be the victims of police killings. Nurses are in a unique and powerful position to confront structural racism, but doing so requires taking on an antiracist approach to nursing practice. This call to action offers a starting place for all nurses.
Full thickness penile skin necrosis following HIPEC: Case report and literature review.

Abstract Heated intraperitoneal chemotherapy (HIPEC) is commonly performed at the time of tumor resection for metastatic intraabdominal tumors. Post operative complications, such as superficial wound infections or bowel leaks are common. They are largely thought to be secondary to poor wound healing due to chemotherapy-associated neutropenia. Scrotal eschars resulting in full-thickness skin necrosis have rarely been reported as a delayed complication after HIPEC. Here, we present the first case report of penile full-thickness skin necrosis after abdominal cytoreduction with HIPEC combined with ventral hernia repair and mesh placement.
Introduction: Defining Pre-Raphaelite Poetics

This edited collection defines Pre-Raphaelite poetics by its plurality. We place their forms of self-expression under this rubric of plurality to designate gender fluidity, cultural borrowing, innovation, and evolution as the substrate for all Pre-Raphaelite forms of making. Moreover, we position Pre-Raphaelite poetics broadly in the sense of poiesis [italicize poiesis], or acts of making. Our collection, therefore, like the Pre-Raphaelites returns to these origins in our endeavor to understand their poetics. In doing so, the definitional capacity of this collection extends from poetry to music to visual arts, as well as to the making of the Pre-Raphaelites as a society themselves.
Interfacial Reaction Rate Constant of Nitrogen with Liquid Cobalt Measured by Nitrogen Isotope Exchange

The nitrogen isotope exchange reaction was applied to measure the interfacial reaction rate constant of nitrogen with liquid cobalt at 1823 K, 1873 K, and 1923 K. Measured values increased with increasing temperature, with average values of 1.3×10−7 mol cm−2 s−1 atm−1 at 1823 K, 3.3×10−7 mol cm−2 s−1 atm−1 at 1873 K, and 6.2×10−7 mol cm−2 s−1 atm−1 at 1923 K. Compared with liquid iron, the rate on cobalt is more than an order of magnitude smaller.
OmniPose: A Multi-Scale Framework for Multi-Person Pose Estimation

We propose OmniPose, a single-pass, end-to-end trainable framework, that achieves state-of-the-art results for multi-person pose estimation. Using a novel waterfall module, the OmniPose architecture leverages multi-scale feature representations that increase the effectiveness of backbone feature extractors, without the need for post-processing. OmniPose incorporates contextual information across scales and joint localization with Gaussian heatmap modulation at the multi-scale feature extractor to estimate human pose with state-of-the-art accuracy. The multi-scale representations, obtained by the improved waterfall module in OmniPose, leverage the efficiency of progressive filtering in the cascade architecture, while maintaining multi-scale fields-of-view comparable to spatial pyramid configurations. Our results on multiple datasets demonstrate that OmniPose, with an improved HRNet backbone and waterfall module, is a robust and efficient architecture for multi-person pose estimation that achieves state-of-the-art results.
Abstract 07: Collecting Duct (Pro) Renin Receptor(PRR) Promotes Kidney Fibrosis Via Macrophage Alternative Activation Mediated By Soluble PRR (sPRR)-Dependent Activation Of Yap/Taz Axis

Renal collecting duct (CD), an important site for fine-tuning urinary Na+ and water excretion, is not traditionally thought to play a role in pathogenesis of chronic kidney disease. In the present ...
Systematic Application of Wood Data

This book is not concerned directly with wood identification, although recognition of the wood features discussed in the preceding chapters is essential for work in wood identification. The present chapter is concerned with establishment of degrees of relationship. In wood identification, a match of an unknown wood with known woods is attempted by looking for diagnostic features. In systematic application of wood data, degrees of difference among species, genera, and families are assessed. In some studies, a number of similarities are present between taxa judged to be related on the sum of evidence. In such woods, which features are indicative of relationships, and which resemblances are indicative of parallel evolution?
Classification in Very High Dimensional Problems with Handfuls of Examples

Modern classification techniques perform well when the number of training examples exceed the number of features. If, however, the number of features greatly exceed the number of training examples, then these same techniques can fail. To address this problem, we present a hierarchical Bayesian framework that shares information between features by modeling similarities between their parameters. We believe this approach is applicable to many sparse, high dimensional problems and especially relevant to those with both spatial and temporal components. One such problem is fMRI time series, and we present a case study that shows how we can successfully classify in this domain with 80,000 original features and only 2 training examples per class.
ANALYSIS OF STORED FUEL, CONTROL ROD AND INHERENT SOURCE EFFECTS ON THE CRBR EX-VESSEL SOURCE RANGE MONITORING SYSTEM

ABSTRACT In order to determine the feasibility of an ex-vessel low-level flux.monitor for use in the Clinch River Breeder Reactor, several possible problem areas needed to be analyzed. Among these were the effect of stored fuel on the detector, and the effect of control rod movements and source changes during refueling. This paper describes the techniques used and the results of such an analysis which was performed at ORNL in cooperation with the AEC and W ARD.
"There is nothing either good or bad, but thinking makes it so": ethics, technology and the engineer

This discussion focuses on the ethics and how the engineer may apply ethical principles in the world of technology. The paper introduces a basic ethical theory and then presents some unique ethical roles of the engineer in technology.
The high stakes of temporality

As the title suggests, Nicolas De Warren’s Husserl and the Promise of Time is an ambitious book. The author not only offers a rigorous reconstruction of Husserl’s phenomenology of time, but also endeavors to articulate what is philosophically promising about it. While careful reconstruction and interpretation of Husserl’s intricate time-analyses can also be found in other monographs and papers—for example, Kortooms 2002, to cite only the most complete one—an original and strong philosophical statement about why these analyses are interesting to philosophize in the present is something this reviewer has found exclusively in De Warren’s book. It goes without saying that De Warren is not the first phenomenologist to have capitalized on Husserl’s time-analyses. Even a cursory look at the history of phenomenology reveals that virtually every phenomenologist after Husserl was in some way inspired by his work on time-consciousness. Heidegger’s Being and Time or Levinas’s Totality and Infinity (to name but two particularly prominent cases) can be viewed as brilliant attempts to rethink and amplify the notion of temporality originally explored by the founder of phenomenology. However, every single phenomenological work in which a serious effort was made to articulate an original standpoint on temporality is generally characterized by a departure from, or at least a criticism of, Husserl’s approach. In some cases, it has been alleged that Husserl’s discoveries about time-consciousness stand in a sharp tension, if not utter contradiction, with his conception of transcendental subjectivity as the absolute and self-transparent foundation of all further being. Given this background, the novelty of De Warren’s position consists in his thoroughly positive disposition towards Husserl’s achievements. The originality of his conclusions is not achieved via a critique of Husserl but rather via an attempt to spell out creatively the philosophical consequences of his work on temporality. This, however, is not just a
The behavior of graphite under biaxial tension

Abstract A small-deformation elastic-plastic continuum theory for describing the stressstrain behavior of graphite is examined for specimens under biaxial loading at room temperature. The continuum theory takes into account the anisotropy and plastic compressibility of graphite as well as the continuous nonlinearity of the stress-strain response. The measured strains for thin-walled cylindrical shells loaded by internal pressure are shown to agree very closely with the predictions of the theory for both loading and unloading.
Prostate Cancer Knowledge and Decision Making Among African-American Men and Women in the Southeastern United States

This study used multiple methods for assessing African-American (AA) men's and their female relatives, friends, and significant others' knowledge and cancer-related decision-making practices within the context of a prostate cancer (PrCA) education program. Data were collected from 81 participants using qualitative focus groups and 49 participants also completed quantitative pre/post surveys. Findings showed that men often relied on their female "significant other" and doctors for guidance on cancer-related decisions. Women described their role in assisting with their male partners' cancer decisions. AA men's and women's knowledge scores increased between pre- and post-tests which can indicate a greater likelihood of future participation in informed cancer-related decision making. Also, using multiple methods in formative research can provide relevant information for developing effective cancer-related interventions.
Equilibrium theory of an electron spiral torus in a neutral background gas

Summary form only given, as follows. The radial equilibrium for an infinite aspect-ratio electron spiral (EST) has been analyzed. In the EST, a thin (typically one electron layer thick) toroidal electron shell surrounds a toroidal ion cloud of constant density. The ions provide a radial equilibrium force for the electrons. An ambient gas pressure is assumed, and is required for ion equilibrium. We consider the case where the electrons have only an poloidal velocity /spl upsi//sub e/spl phi//. Under the general constraint of conservation of poloidal current, the product n/sub e/r/spl upsi//sub e/spl phi//. must be constant as a function of poloidal position. Under certain assumptions for the electron and ion density distributions, the electron and ion force equations decouple and can be solved separately. We compare the resulting ion density and velocity solutions with energy density predictions from the virial theorem.