cssi/SciSciGPT-SciSciNet huggingface dataset:
Hypercalcemia in a woman with hypoparathyroidism associated with increased parathyroid hormone-related protein during lactation.

ABSTRACT Objective To report a case of postpartum hypercalcemia in a woman with hypoparathyroidism associated with increased serum concentrations of parathyroid hormone-related protein (PTHrP) during lactation. Methods The clinical and laboratory data for our patient and the related literature are reviewed. Results A 35-year-old woman with long-standing surgical hypoparathyroidism treated with dihydrotachysterol and calcium carbonate gave birth to a healthy boy at 40 weeks of gestation and began lactating normally. Two and a half weeks later, hypercalcemia developed in association with nausea, vomiting, and myalgias. Subsequently, an increased serum PTHrP concentration was noted. After saline diuresis and corticosteroid therapy to correct the hypercalcemia, a normal serum calcium level was maintained without vitamin D preparations or calcium supplements until the 12th postpartum week, when hypocalcemia reappeared. The serum PTHrP level was no longer increased, and treatment with calcitriol and calcium carbonate was resumed. Subsequent serum calcium concentrations have been normal. Conclusion This case suggests that PTHrP stimulation of the parathyroid hormone-PTHrP receptor during lactation may compensate for the absence of parathyroid hormone in lactating women with hypoparathyroidism and that treatment with pharmacologic doses of vitamin D preparations during the postpartum period may result in hypercalcemia. (Endocr Pract. 1999;5:198-200)
Classification of Epileptic EEG Using Neural Network and Wavelet Transform

Arthur Petrosian*, Richard Homan*, Danil Prokhorov, Donald Wunsch II*Tex Tech University Health Sciences Center,Department of Neurology, 3601 4th Street, Lubbock, TX 79430E-mail: neuaap@uuhsc.eduTexas Tech University, Depariment of Electrical Engineering,Box 43102, Lubbock, TX 79409-3102ABSTRACTOne of the major conthbutions of electroencephalography has been its application in the diagnosis and clinical
TREADS: a safe route recommender using social media mining and text summarization

This paper presents TREADS, a novel travel route recommendation system that suggests safe travel itineraries in real time by incorporating social media data resources and points of interest review summarization techniques. The system consists of an efficient route recommendation service that considers safety and user interest factors, a transportation related tweets retriever with high accuracy, and a novel text summarization module that provides summaries of location based Twitter data and Yelp reviews to enhance our route recommendation service. We demonstrate the system by utilizing crime and points of interest data in the Washington DC area. TREADS is targeted to provide safe, effective, and convenient travel strategies for commuters and tourists. Our proposed system, integrated with multiple social media resources, can greatly improve the travel experience for tourists in unfamiliar cities.
A phenomenological model of dynamical arrest of electron transfer in solvents in the glass-transition region

A phenomenological model of electron transfer reactions in solvents undergoing glass transition is discussed. The reaction constant cuts off slow polarization modes from the spectrum of nuclear thermal motions active on the observation time scale. The arrest of nuclear solvation in turn affects the reaction activation barrier making it dependent on the rate. The resultant rate constant is sought from a self-consistent equation. The model describes well the sharp change in the solvent Stokes shift of optical lines in the glass-transition region. It is also applied to describe the temperature dependence of primary charge separation and reduction of primary pair in photosynthetic reaction centers. The model shows that a weak dependence of the primary charge separation rate on temperature can be explained by dynamical arrest of nuclear solvation on the picosecond time scale of electron transfer. For reduction of primary pair by cytochrome, the model yields a sharp turnover of the reaction kinetics at the transition temperature when nuclear solvation freezes in.
Organic compounds with nonlinear optical response enhanced by microparticles prepared at low gravity

We will present the results of study of nonlinear optical organic compounds based on dye doped polymeric micron size spherical particles. These particles are generated on the ground at artificial low gravity. Free falling drops of polymer solution or metal take on the shape close to spherical. The fabrication at real low gravity can substantially improve the sphericity of the particles and their identity. We show that the particles, being combined with different organic chromophores, can potentially increase their nonlinear optical response in practical applications. This effect is associated with the break of symmetry at the particle surface and the interaction of the resonant modes with non-symmetrical molecules at the particle surface. Constructive light interference in an array of microspheres additionally enhances nonlinear response. In our experiments we used polystyrene microspheres with diameter from 1.7 to 5.3 microns. Two- dimensional quasi-crystals were fabricated from polystyrene microspheres and characterized for their structural and nonlinear optical properties. The quasi-crystals were produced with the method based on Langmuir-Blodgett thin film technique. As possible dopants we studied a NPO dye, derivatives of DIVA, disperse dyes. Some of the create Langmuir-Blodgett films combined with spherical particles in the same technological process.© (1996) COPYRIGHT SPIE--The International Society for Optical Engineering. Downloading of the abstract is permitted for personal use only.
E. coli DNA associated with isolated Hfq interacts with Hfq's distal surface and C-terminal domain

Abstract The RNA-binding protein Hfq has been studied extensively for its function as a modulator of gene expression at the post-transcriptional level. While most Hfq studies have focused on the protein's interaction with sRNAs and mRNAs, Hfq binding to DNA has been observed but is less explored. During the isolation of Hfq from Escherichia coli, we found genomic DNA fragments associated with the protein after multiple steps of purification. Sequences of 41 amplified segments from the DNA fragments associated with Hfq were determined. A large fraction of the DNA segments were predicted to have significant helical axis curvature and were from genes associated with membrane proteins, characteristics unexpected for non-specific binding. Analysis by analytical ultracentrifugation indicated that rA18 binding to Hfq disrupts Hfq-DNA interactions. The latter observation suggests Hfq binding to DNA involves its distal surface. This was supported by a gel mobility shift assay that showed single amino acid mutations on the distal surface of Hfq inhibited Hfq binding to duplex DNA, while six of seven mutations on the proximal surface and outer circumference of the hexamer did not prevent Hfq binding. Two mutated Hfq which have portions of their C-terminal domain removed also failed to bind to DNA. The apparent Kd for binding wild type Hfq to several duplex DNA was estimated from a gel mobility shift assay to be ~ 400 nM.
Comparison of classical and Bayesian models using BLR

The modeling of storage reliability using binary logistic regression allows for one to explore the causal or correlative variable relationships that affect the outcome of binary (pass/fail) tests. Both classical and Bayesian models show good agreement when the amount of data available is large as it should. Bayesian models should add some value for situations in which there are only small amounts of testing information.
Mobile apps for nature field guides

Purpose – ‐‐ The purpose of this paper is to provide a brief introduction to software applications that make nature field guides accessible on computers, including desktop and mobile devices such as smartphones and tablets, and to describe some specific products that are available.Design/methodology/approach ‐‐ This article discusses the development and proliferation of software applications or “apps” for nature field guides. Common features of such apps and some specific examples are presented.Findings ‐‐ Numerous field guide apps are available for identifying animals, plants, and other natural phenomena using mobile computing devices or smartphones. Apps for mobile devices retain the traditional quality of portability for field guides, and most of these apps offer high quality photographs along with descriptive text. Some products include audio files for identifying bird songs or frog calls. Features for users include the ability to maintain life lists and to search guide contents using graphic icons, a...
Integrating human development research and intervention for America's children: The Michigan State University model

Abstract Across America, coalitions involving private, nonprofit agencies, advocacy groups, governmental units, academic institutions, and communities are forming in order to prevent or diminish the actualization of risk behaviors among children and families. This article describes ane such collaboration, involving the Institute for Children, Youth, and Families (ICYF) at Michigan State University and other sectors of the communities of Michigan. The participation of the ICYF in this coalition is predicated on the vision of the role of a land-grant institution as using its scholarly abilities (for knowledge generation, transmission, and application) to serve the people of its state. We discuss the land-grant philosophy and the developmental contextual theory of human ecology and developmental that is associated with these institutions' colleges of home economics (and their evolutionary heirs, i.e., colleges of human ecology, human development, human environmental sciences, and many others). The use of this theory for building ICYF programs of research and intervention is discussed, and an overview of these programs is presented. In addition, some of the challenges and problems in advancing these programs are noted. We conclude that a multidisciplinary, multiprofessional, and community-collaborative synthesis of research, policies, and programs—one focusing on the human diversity and contextual variation present in different communities—is necessary to advance understanding of, and service to, the needs of children and families.
Communicating Qualitative and Quantitative Decision Support Information

The effective communication of decision support requires the appropriate integration of quantitative and qualitative data and information in both written and oral interactions with decision makers.
Cell-cycle regulation of center initiation in Dictyostelium discoideum.

Abstract The center-initiating behavior of Dictyostelium discoideum amoebae in various cell-cycle phases was investigated. Small populations of synchronized AX-2 cells were seeded 1 in 1000 into cultures of a nonsignaling mutant (NP160) incapable of initiating centers. The ability of the wild-type AX-2 cells to initiate centers among mutant amoebae displayed cell-cycle regulation. Approximately 50% of a population of S-phase cells initiated centers while only 7.5% of a population of late G2-phase cells resulted in center formation. The timing of center formation also varied with cycle position. Synchronous cultures containing only AX-2S-phase amoebae (no NP160) displayed the initial signs of aggregation after 4.5 hr of starvation and streaming into the aggregate was complete after 6 hr. In contrast, cultures of late G2-phase amoebae initiated aggregation centers after 5.5 hr of starvation and did not complete streaming until 7.5 hr. In addition, the number of aggregates formed by these synchronous cultures of AX-2 cells also varied with cycle position. In general, these results suggest a cell-cycle modulation of the autonomous signaling responsible for center initiation.
PRODUCTION OF ETHYLENE AND PROPYLENE FROM ETHANE, PROPANE, AND N-BUTANE MIXED WITH STEAM IN A MICROWAVE-IRRADIATED SILICON-CARBIDE LOADED REACTOR

ABSTRACT We studied the production of ethylene (C2") and propylene (C3") by the decomposition of pure ethane, propane, and n-butane, mixed with steam, in a microwave-irradiated fixed bed reactor packed with silicon carbide. We found that ethylene production was maximized using ethane as the feed, with per pass yields as high as 63% at an ethane conversion level of 74%. With propane and n-butane feeds, more ethylene than propylene was produced, but the propylene amounts were significant. Combined per pass yields of C2" and C3" were 56% at a butane conversion of 99%, and 50% at a propane conversion of 93%. This microwave process appears to be a viable way of producing ethylene and propylene.
Pure Oxygen Breathing Increases Sheep Lung Microvascular Permeability

Sheep that breathe pure oxygen via a tracheostomy develop progressive respiratory failure and die within four days. The characteristic terminal findings include an increased water content of the lung, a decrease in lung compliance, and severe hypercarbia. To sequentially assess alterations of lung transvascular fluid dynamics during prolonged oxygen breathing the authors measured lung lymph flow (Q lymph), protein transport (Q protein), and pulmonary vascular pressures in five sheep with chronic lung lymph fistulas. No significant changes of lung transvascular fluid dynamics occurred during the first 60 hours of oxygen breathing, although an increasing trend of Q lymph and Q protein was demonstrable. However, after 72 hours of oxygen breathing, Q lymph, Q protein, and extravascular lung water had increased significantly without any change of pulmonary vascular pressures. The authors conclude that the toxic effects of oxygen on the lungs of sheep include a delayed but marked increase of pulmonary microvascular permeability to protein and fluid.
Action of sex steroid hormones on temperature-induced sex determination in the snapping turtle (Chelydra serpentina).

Administration of exogenous estradiol benzoate (EB) or an estrogen agonist, R2858, into eggs of snapping turtles caused all embryos incubated at male-producing temperatures to develop as females, whereas testosterone propionate (TP) caused 42% of the embryos to develop as females. Some of the embryos treated with EB, R2858, or TP also had hypertrophied oviducts. Neither dihydrotestosterone (DHT) nor cholesterol had any apparent effect on the sex determination of embryos incubated at male-producing temperatures. Injections of TP, DHT, the androgen agonist R1881, or cholesterol had no apparent effect on sex determination of embryos incubated at female-producing temperatures. Administration of estradiol antiserum or testosterone antiserum resulted in some individuals having undifferentiated or ambiguous gonads. Although both exogenous estrogens and androgens can induce embryonic gonads to develop as ovaries, the findings of this study indicate that estrogen is the female-inducing hormone and that androgens may feminize gonads via aromatization to estrogen. Furthermore, the results of the antisera injections suggest that endogenous steroid hormones may have a natural role in gonadal differentiation of reptiles with environmental sex determination.
A boundary integral method applied to plates of arbitrary plan form and arbitrary boundary conditions

Abstract An integral equation method which has been applied to thin elastic clamped plates of arbitrary plan form[1] has been extended to include arbitrary boundary conditions. Numerical difficulties which arise in the case of free boundaries have been avoided by defining an integration contour which differs from the actual plate boundary. Thus second order singularities which arise in the integrand of the equations are avoided. The method is applied to two rectangular plates with mixed boundary conditions (i.e. clamped, simply-supported and free edges). Average errors are 1.5% for displacements and 3% for bending moments.
Travel and Oral Anticoagulants

In their article Jurgen Ringwald and colleagues 1 do not take into account that in the United States there are only 50,000 international normalized ratio (INR) self‐testers out of 4 million people on warfarin (1.25%).2 In the United States, travel medicine providers should understand the ways in which warfarin is managed: usual care (UC) by the patients' regular physician; Anticoagulation Clinic Care (ACC), which are specialized programs that are focused on the management of anticoagulant medications; and by patient self‐testing and patient self‐management (PST/PSM).3 Travel medicine providers should work closely with all these clinicians. The article's advice on managing elevated INR levels is beyond the scope of a Journal of Travel Medicine article because it is much …
Low Complexity List Updating Circuits for List Sphere Decoders

Sphere decoder has been introduced to the multiple-input-multiple-output (MIMO) communication systems, with which the maximum likelihood (ML) detection becomes feasible. In order to combine the sphere decoders with the outer channel code decoder, researchers have proposed to include a candidate list in the sphere decoder to provide soft information to the channel code decoder. This algorithm is called list sphere decoder (LSD). In the LSD, different from the conventional sphere decoder (CSD), the candidate list introduces significant hardware overhead. In this paper, we propose to use a tree-type comparator array, a link table and sublists to reduce the hardware complexity of inserting new candidates into the list. Combining these techniques, we can reduce the complexity by around 90% compared with the straightforward implementations.
Massively parallel implementation of a 3D vortex-boundary element method

Vortex-boundary element simulation of three-dimensional wall-bounded flows is performed on a massively parallel architecture using the data parallel paradigm. With proper optimization, implementation on the Thinking Machines CM5 is shown to yield over an order of magnitude speed-up over the Cray C90, using 128 processors. This makes the direct evaluation of the flow eld represented by up to 100 000 vortex elements feasible. In this paper, the CPU time and memory requirements for the direct evaluation of the vortical eld using three parallelization algorithms are compared. In addition, performance results for the evaluation of the vortical and potential velocities, and their gradients, are presented as a function of the number of vortex elements and the number of processing nodes. Finally, to demonstrate the capability of the developed method, preliminary results from the case of flow around a stationary, idealized trailer truck near the ground level at Re = 500 are presented.
Asymmetric treatment of reported pension expense and income amounts in CEO cash compensation calculations

Abstract We provide evidence that CEO cash compensation is relatively less sensitive to pension expense than pension income, suggesting that compensation committees shield CEO cash compensation from pension expense amounts. We also provide evidence that managers use relatively higher expected rate of return estimates when reporting pension income, suggesting that managers select income-increasing accounting estimates in response to compensation committees’ greater emphasis on pension income in CEO cash compensation determinations. Pension cost amounts represent a unique setting to examine such behavior as their effect on CEO cash compensation can be detrimental or beneficial, but arise from the same underlying economic activity.
The influence of hosts, temperature and food sources on the longevity of Trichogramma platneri

Feeding experiments were conducted with Trichogramma platneri Nagarkatti (Hymenoptera: Trichogrammatidae) reared from the Angoumois grain moth, Sitotroga cerealella (Oliver) (Lepidoptera: Gelechiidae). T. platneri provisioned with host eggs do not live any longer than T. platneri without host eggs. Longevity of T. platneri is inversely related to temperature declining from 53 days at 10 °C to 3 days at 35 °C for honey-fed parasitoids and from 9 days at 10 °C to 1 day at 35 °C for unfed parasitoids. Sugar sources are necessary to prolong longevity of T. platneri, but a source of amino acid did not promote longevity. Honey solutions greater than 10%, and 43% fructose and sucrose solutions increased longevity 10–13 fold to 15–20 days in comparison to water when fed daily to T. platneri. Parasitoids fed only at the onset of the trial had greater longevity than unfed parasitoids but had a shorter longevity than parasitoids fed daily, due to the evaporation of the sugar solutions and consumption of the honey. Aphid honeydew is a suitable field-available sugar source supporting longevity up to 10 days, but is not as good as other sugar sources. Stabilizing additives did not reduce evaporation of a dilute sugar solution nor prolong longevity of T. platneri. Simulating a daily dew fall by misting vials, to redissolve the crystallized food residues left after providing food at the onset of the trial, failed to increase parasitoid longevity.
Colorful tails fade when lizards adopt less risky behaviors

Colorful tails that become cryptic during ontogeny are found in diverse taxa. Nevertheless, the evolutionary bases for this change remain debated. Recent work suggests that colorful tails, deflective displays, and striped patterns may represent antipredator mechanisms used by immature lizards to compensate for being more active and hence more vulnerable to predation (increased movement hypothesis, IMH). I challenged the generality of IMH by comparing foraging behavior and frequency of tail displays across five Acanthodactylus lizards that vary in fundamental life history traits, before and after the tail changed color. As these species underwent changes in tail coloration, they congruently adopted less risky behaviors and reduced the frequencies of tail displays. Contrary to expectation, in two species, the hatchling risky behavior resulted not from increased movements but from longer stay in exposed microhabitats. I suggest that colorful tails and deflective tail displays are synergistic antipredator mechanisms neonates use to minimize the fitness consequences of using various risky behaviors rather than increased movement alone.
A qualitative ellipsometric-electrochemical approach to the study of film growth under organic coatings

Abstract A study was made to determine if qualitative ellipsometry could be used together with electrochemical pH and potential measurements as a technique for the study of metal substrates protected by transparent organic coatings. The objective was to gain a deeper understanding of the mechanisms governing the corrosion protective actions of paints on metal surfaces. Computer modeling and experiments with collodion coatings on iron substrates indicated that changes in the ellipsometric parameter Δ could, for the most part, be safely interpreted as thickness alterations in the substrate oxide film. Experiments with the Fe-collodion system in dilute chloride solutions exhibited three sequential stages of activity, two of which could be interpreted in terms of corrosion mechanisms using the optical and electrochemical measurements. Chromate ion as a corrosion inhibitor in coatings was also studied using this technique, and was shown to have significant effects upon the development of the subcoating processes.
Legal-Political Pressures and African American Access to Managerial Jobs

Prior work on equal employment opportunity tends to focus on a limited set of factors that influence change in organizational structures and policies. This article considers a broader set of potent...
Clock-Transport Synchronization in Noninertial Frames and Gravitational Fields

It is shown that electromagnetic and clock-transport synchronization procedures are not necessarily equivalent. In noninertial frames and in gravitational fields both procedures can be path dependent. Even for the same path \ensuremath{\sim} 100 km above the Earth, the two procedures can give different errors, \ensuremath{\sim} 89 \ensuremath{\mu}sec/day (clock-transport synchronization) and \ensuremath{\sim} 60 \ensuremath{\mu}sec/day (electromagnetic synchronization).
Device reliability issues in field emission displays

Field emission displays are currently making the transition from R&D into prototypes and early production. Device reliability is a critical issue in realization of successful field emission displays that are able to compete with other established technologies like active matrix liquid crystal displays and thin film electroluminescent displays. In this paper, we review the fundamental issues affecting the reliability and operational life of field emission display systems.
Trace elements and the panspermia hypotheses

Abstract The modal concentrations of elements in four representative classes of organisms, namely bacteria, fungi, plants, and land animals, are compared with the concentrations of the elements in sea water. A strong correlation is found between these concentrations, and this correlation reduces to an expected linear concentration law when only “trace” elements are considered. Deviations from strict linearity are shown to arise from the chemical natures of the elements Apart from suggesting an oceanic genesis for terrestrial life, the data are strongly against a nonterrestrial origin of life as proposed by the panspermia hypotheses.
Regulation of PDK mRNA by high fatty acid and glucose in pancreatic islets.

Abstract Pyruvate dehydrogenase (PDH) converts pyruvate to acetyl-CoA, links glycolysis to the Krebs cycle, and plays an important role in glucose metabolism and insulin secretion in pancreatic β cells. In β cells from obese and Type 2 diabetic animals, PDH activity is significantly reduced. PDH is negatively regulated by multiple pyruvate dehydrogenase kinase (PDK) isotypes (PDK subtypes 1–4). However, we do not know whether fatty acids or high glucose modulate PDKs in islets. To test this we determined PDH and PDK activities and PDK gene and protein expression in C57BL/6 mouse islets. Both high palmitate and high glucose reduced active PDH activity and increased PDK activity. The gene and protein for PDK3 were not expressed in islets. Palmitate up-regulated mRNA expression of PDK1 (2.9-fold), PDK2 (1.9-fold), and PDK4 (3.1-fold). High glucose increased PDK1 (1.8-fold) and PDK2 (2.7-fold) mRNA expression but reduced PDK4 mRNA expression by 40 percent in cultured islets. Changed PDK expression was confirmed by Western blotting. These results demonstrate that in islet cells both fat and glucose regulate PDK gene and protein expression and indicate that hyperglycemia and hyperlipidemia contribute to the decline in diabetic islet PDH activity by increasing mRNA and protein expression of PDK.
International Perspectives on Elder Abuse: Five Case Studies

This introduction to the special issue on international perspectives on elder abuse presents basic elements of a cognitive-ecological approach to elder abuse. It also describes the research project out of which the current set of studies emerged, and provides a rationale for the five case studies (Japan, Germany, African Americans, Israel and Brazil) focused on in this issue.
Simulations of zigzag maneuvers for a container ship with direct moving rudder and propeller

Abstract Simulations of zigzag maneuvers of the Postdam Model Basin (SVA) Korean container ship (KCS) model with moving rudder and rotating propeller are presented. Free running KCS presents considerable challenges to simulate the moving semi-balanced horn rudder which presents tight gaps with the rudder root. These difficulties are overcome using a dynamic overset technique with a hierarchy of bodies. To better resolve propeller/rudder interaction a Delayed Detached Eddy Simulation turbulence model based on Menter’s SST is used. Two types of maneuvers are simulated, the standard 10/10 zigzag maneuver and the modified 15/1 zigzag maneuver. Both simulations are performed at model scale in deep, calm water, for approach velocities corresponding to a Froude number 0.26. The self-propulsion at approach speed is achieved using a proportional–integral speed controller which acts on the propeller rotational speed with the ship free to surge, heave, roll and pitch. Once the ship achieves self-propulsion the propeller rotational speed is frozen and the ship is free to move in six degrees of freedom (6DOF) while the maneuver starts. The results show that direct Computational Fluid Dynamics (CFD) simulations of maneuvers with a moving rudder and rotating propeller are feasible and the comparisons between computations and experiments are highly satisfactory in both cases, but the computational cost is still high for many applications. In analyzing the flow physics, it is found that the rudder has asymmetric behavior caused by the asymmetry introduced by the single rotating propeller.
Direct measurement of the enthalpy of fusion of diopside

Crystalline diopside, CaMgSi2O6, was dropped directly into a Setaram “HT1500” calorimeter operating at high temperature. At 1575 < T < 1624 K, the heat content of the crystals was in excellent agreement with previously published results. Above 1634 K, a rise in the enthalpy was seen, supporting the incongruent melting reported by Kushiro. The total enthalpy of fusion at 1665 K, the nominal melting point, is 138.5 kJ/mol, in excellent agreement with measurements which used a cycle that involves dropping the liquid to form a glass and measuring heats of solution of glass and crystals. The heat content of a glassy diopside starting material was also measured. Because the calorimetric experiment lasts only about 8 minutes, these measurements could be extended into the supercooled liquid range (to 1170 K) before the onset of rapid crystallization. A change in slope in the measured heat contents gives a glass transition temperature of 933 K, about 70 K lower than that reported by other methods. A linear fit of all the data above T8 (supercooled liquid at 970 to 1170 K, stable liquid at 1668 to 1766 K) gives an average heat capacity for the liquid of 332.8 J/mol · K, comparable to the value of 334.6 J/mol · K reported by Richet and Bottinga.
Age and Work-Related Outcomes: The Moderating Effects of Status Characteristics

This study examines the extent to which 2 status characteristics—pay level and part-time vs. full-time employment—influence the effectiveness of age as a predictor of work-related attitudes and behaviors. Using a sample of 157 registered nurses, hierarchical regression was used to determine whether pay level or employment classification (part-time vs. full-time) moderated the relationship between chronological age and the following outcomes associated with the process of voluntary turnover: job satisfaction, organizational commitment, withdrawal cognitions, perceived alternatives, search behavior, and actual turnover behavior. Findings indicate that the effects of age on work attitudes and behaviors are moderated to some extent by both status characteristics. Implications for research and practice are discussed.
The Karyopherin Kap122p/Pdr6p Imports Both Subunits of the Transcription Factor Iia into the Nucleus

We discovered a nuclear import pathway mediated by the product of the previously identified Saccharomyces cerevisiae gene PDR6 (pleiotropic drug resistance). This gene product functions as a karyopherin (Kap) for nuclear import. Consistent with previously proposed nomenclature, we have renamed this gene KAP122. Kap122p was localized both to the cytoplasm and the nucleus. As a prominent import substrate of Kap122p, we identified the complex of the large and small subunit (Toa1p and Toa2p, respectively) of the general transcription factor IIA (TFIIA). Recombinant GST-Kap122p formed a complex with recombinant His6-Toa1p/Toa2p. In wild-type cells, Toa1p and Toa2p were localized to the nucleus. Consistent with Kap122p being the principal Kap for import of the Toa1p–Toa2p complex, we found that deletion of KAP122 results in increased cytoplasmic localization of both Toa1p and Toa2p. Deletion of KAP122 is not lethal, although deletion of TOA1 and TOA2 is. Together these data suggest that Kap122p is the major Kap for the import of Toa1p–Toa2p into the nucleus. Like other substrate–Kap complexes, the Toa1p/Toa2p/Kap122p complex isolated from yeast cytosol or reconstituted from recombinant proteins, was dissociated by RanGTP but not RanGDP. Kap122p bound to nucleoporins, specifically, to the peptide repeat–containing fragments of Nup1p and Nup2p.
Lean-limit extinction of propane/air mixtures in the stagnation-point flow

The extinction limits of lean propane/air mixtures in the stagnation-point flow of a flat surface were mapped as functions of the surface temperature and the mixture concentration, velocity, and temperature. The maximum flame temperatures and the flame locations were also measured. The results show that the extinction limits are extremely insensitive to the nature of the surface, which can be heated to 1000 C. On the other hand preheating the gas mixture increases the flame temperature by an almost equal amount and therefore significantly extends the extinction limits. It is also found that at extinction the maximum flame temperatures and the flame locations, which when scaled with the velocity gradient, assume almost constant values independent of the other system variables investigated.
Dynamic Simulation of an Integrated Solid Oxide Fuel Cell System Including Current-Based Fuel Flow Control

A two-dimensional dynamic model was created for a Siemens Westinghouse type tubular solid oxide fuel cell (SOFC). This SOFC model was integrated with simulation modules for other system components (e.g., reformer, combustion chamber, and dissipater) to comprise a system model that can simulate an integrated 25 kilowatt SOFC system located at the University of California, Irvine. A comparison of steady-state model results to data suggests that the integrated model can well predict actual system power performance to within 3 percent, and temperature to within 5 percent. In addition, the model predictions well characterize observed voltage and temperature transients that are representative of tubular SOFC system performance. The characteristic voltage transient due to changes in SOFC hydrogen concentration has a time scale that is shown to be on the order of seconds while the characteristic temperature transient is on the order of hours. Voltage transients due to hydrogen concentration change are investigated in detail. Particularly, the results reinforce the importance of maintaining fuel utilization during transient operation. The model is shown to be a useful tool for investigating the impacts of component response characteristics on overall system dynamic performance. Current-based flow control (CBFC), a control strategy of changing the fuel flow rate in proportion to the fuel cell current is tested and shown to be highly effective. The results further demonstrate the impact of fuel flow delay that may result from slow dynamic responses of control valves, and that such flow delays impose major limitations on the system transient response capability.Copyright © 2005 by ASME
Testing independence of variates in an infinitely divisible random vector

Abstract A method is given for testing the independence of variates in an infinitely divisible random vector and for testing the independence of several subsets of the variates. Applications to stochastic processes are indicated.
Relative contribution of outdoor and indoor particle sources to indoor concentrations

The effect of indoor particle sources on indoor particle size distributions and concentrations was previously investigated using real-time indoor and outdoor particle size distribution data collected in four homes in Boston in 1996. These data demonstrated the importance of indoor sources (i.e., cooking, cleaning, and movement of people) and air exchange rates on observed indoor concentrations. As part of the continued analyses of these data, a simple physical model was used to determine the source emission and infiltration rates for specific particle sizes. Decay rates were also estimated. Cooking, cleaning, and indoor work (characterized by movement of people) significantly increased PM(0.7-10) concentrations by 0.27, 0.27, and 0.25 μm3 cm-3 min-1, respectively. Cooking was the only variable significantly associated with generation of particles less than 0.5 μm in diameter. Outdoor particles (0.02−0.5 and 0.7−10 μm) were found to contribute significantly to indoor particle levels. Effective penetration ...
Site-specific unfolding thermodynamics of a helix-turn-helix protein.

The thermal unfolding of a 40-residue helix-turn-helix subdomain of the P22 viral coat protein was investigated using circular dichroism (CD) and Fourier transform infrared spectroscopy (FTIR) with site-specific 13C isotopic labeling. Helix-turn-helix is the simplest α-helical structural motif that combines both secondary and tertiary structural elements. The CD of individual helical fragments reveals that the P22 subdomain is stabilized by tertiary interhelical interactions. Overall the temperature-dependent CD and FTIR data can be described by a three-state process with a partially folded intermediate. However, the analysis of the site-specific 13C IR signals reveals distinct unfolding thermodynamics for each of the labeled sites. The thermodynamic parameters of the thermal unfolding of each of the labeled segments were obtained using singular value decomposition in combination with target transformation and global fitting. The P22 subdomain unfolds from the N-terminus toward the helical segments near t...
Ligand and coordination-plane distortions in platinum(II) complexes of isomers of dimethyl-2,2'-bipyridine.

Pseudo-square-planar platinum(II) complexes containing 4,4′ (4,4′-Me2bipy), 5,5′ (5,5′-Me2bipy) and 6,6′ (6,6′-Me2bipy) isomers of dimethyl-2,2′-bipyridine (Me2bipy) were synthesized and structurally characterized to assess the effects of methyl-group position on structure. The Pt—N distances in (Me2bipy)PtCl2 complexes fall in the typical range [2.017 (3)–2.032 (3) A]. Only minor distortions such as 2.4 and 5.5° twisting of the two pyridyl rings in (4,4′-Me2bipy)PtCl2 (I) and (5,5′-Me2bipy)PtCl2 (II), respectively, occur. However, (6,6′-Me2bipy)PtCl2 (III) is highly distorted: the two pyridyl rings in (III) have a large bowing angle (θB) of 19.2°. The presence of distortions in (III), but not in (I) and (II), is attributed to repulsions between the 6,6′-methyl groups and the cis chloro ligands. [(4,4′-Me2bipy)2Pt](BF4)2 (IV) undergoes a bow-incline deformation having a large θB value (24.2°), and the ligands are inclined relative to the coordination plane by 18.80 (13)°. Complex (IV) joins a small list of distorted bis-bipyridine complexes; this finding can be attributed to the unfavorable repulsions between the 6,6′ hydrogen substituents of opposing ligands. Some of these complexes exhibit canting rather than bow-incline distortion, a trend suggesting that subtle solid-state effects determine the nature of the distortion.
Regional distribution of endorphin, met5-enkephalin and leu5-enkephalin in the pigeon brain

Abstract The distribution of β-endorphin and enkephalin in the pigeon forebrain by immunohistochemistry and radioimmunoassay is essentially analogous to mammals. Both endorphin- and enkephalin-reactive fibers have a similar periventricular distribution, but the enkephalin fibers are more extensive and are also found in the paleostriatum, limbic regions and brain stem, pituitary stalk and notably, penetrating the organum vasculosum hypothalami. There was poor correlation between endorphin and enkephalin regional contents by radioimmunoassay. In contrast, a highly significant correlation was observed between Met 5 -enkephalin and Leu 5 -enkephalin regional distribution. These data support the view that enkephalin neurons and endorphin neurons are independent central neuronal systems.
Immunocytochemical localization and messenger ribonucleicacid concentrations for human placental lactogen in amnion, chorion, decidua, and placenta

Summary Human placental lactogen is one of the major hormones secreted by the placental syncytiotrophoblast anddetected in the maternal circulation. Other sources of this hormone in intrauterine tissues at term have been sought by means of immunohistochemistry and northern analysis. Avidin-biotin immunoperoxidase staining with a specific polyclonal antibody to human placental lactogen showed this hormone to be present in groups of cells at the interface between chorionic cytotrophoblast and decidua parietalis and in some cells of the basal plate in addition to the classic source, the syncytiotrophoblast. Hybridization of polyadenylio-`ribonucleic acid extracted from amnion, chorion, decidua parietalis, basal plate, and placental trophoblast with a radiolabeled 48 mer oligonucleotide and a 540 base pair complementary deoxyribonucleic acid probe to human placental lactogen showed the placental trophoblast to be the major source of human placental lactogen and the extravillous chorion and basal plate to be additional minor sources
A study of user queries leading to a health information website: AfterTheInjury.org

AfterTheInjury.org is a direct to health consumer, empirically-grounded Web-based program that is hosted by an academic medical center. Launched in 2009, it includes information and psycho-education interventional content for parents of injured children. This study analyzes search engine queries that led users to the website in order to better understand the informational needs of users of such a website. Query data were collected for the 2009 calendar year via Google Analytics, a widely used free website statistics and traffic analysis tool. Specific analyses included query length and the presence of question words. Results were compared between external and internal queries. Results from this study were put in the context of existing literature regarding user search behavior. Analyses demonstrated that external search engines were an important source of traffic to AfterTheInjury.org with 1 in 5 visits driven from the most popular search engines, Google, Yahoo and Bing. Queries were longer than typical queries (AfterTheInjury query averaged 6.27 terms; typical medical query, 2.3--2.4 terms). Nearly 1/4 of queries leading to AfterTheInjury.org took the form of questions: 22.7% of external searches were questions with 10.7% of external queries including the term "how". The low "bounce rate" (4.2%) suggested a match between user information needs and the content on AfterTheInjury.org; however, the relatively low number of visits (7,676) given the high number of injured children per year in the US (more than 8,000,000) suggests that parents of injured children with informational needs may not be finding AfterTheInjury.org. These findings highlight the potential utility of query analysis to understand informational needs of users. Query behavior for users of AfterTheInjury.org differed from query behavior for those seeking general information and provide insight into how to improve dissemination strategies for similar health-related websites.
Characterization of specimens exposed in a Li loop

Abstract A monometallic V–4Cr–4Ti thermal convection loop was run for 2355 h with a peak temperature of 700 °C (973 K) and Li flow rate of 2–3 cm/s. Specimens of V–4Cr–4Ti exposed in the hot and cold legs of the loop and tensile tested in vacuum at 500 °C (773 K) showed an increase in the 0.2% yield and ultimate tensile strengths and a decrease in the serration amplitude with decreasing exposure temperature in the loop. However, only minor changes in ductility were measured. With the higher temperature exposures, a decrease in Vickers hardness was measured, but little change in the grain size was observed. Characterization of the microstructure after exposure at 627 °C (900 K) in the loop showed an increase in the density of Ti- and N-rich grain boundary and matrix precipitates near the specimen surface after exposure corresponding to an increase in the hardness in the near-surface region. Two-layer V/Y2O3 coatings on V–4Cr–4Ti substrates also were exposed in the loop, and initial room temperature characterization was conducted.
A Ru(I) Metalloradical That Catalyzes Nitrene Coupling to Azoarenes from Arylazides

Unusual N–N coupling of aryl azides to yield azoarenes is demonstrated by the Ru(I) metalloradical, [SiPiPr3]Ru(N2) (4) ([SiPiPr3] = (2-iPr2PC6H4)3Si–). The yield of the azoarene is dependent on the substituent on the aryl azide, and the reaction is catalytic for p-methoxy and p-ethoxy phenyl azides, while no azoarene is observed for p-trifluoromethylphenyl azide. Studies aimed at probing the viability of a bimolecular coupling mechanism of metal imide species, as shown in the related [SiPiPr3]Fe system, have led to the isolation of several structurally unusual complexes including the ruthenium(IV) imide, 7-OMe, as well as the Ru(II) azide adduct 8-OMe. One electron reduction of 7-OMe complex led to the isolation of the formally Ru(III) imide complex, [SiPiPr3]Ru(NAr) (Ar = p-MeOC6H4, 5-OMe). EPR spectroscopy on 5-OMe suggests that the complex is electronically similar to the previously reported imide complex, [SiPiPr3]Ru(NAr) (Ar = p-CF3C6H4,5-CF3), and features radical character on the NAr moiety, but t...
Effect of hydrophobic side-chains on the solvation of imidazolium salts

The chemical shifts of the aromatic hydrogens of 12 symmetrical imidazolium salts were determined in different deuterated solvents. Based on the magnitude of the chemical shift change for the hydrogens of the imidazolium ion in the various solvents, relationships were developed to determine the relative solute/solvent interactions for these compounds. Owing to different degrees of interactions involving the aromatic hydrogens of the imidazolium cations and anions, there is a variation in the interaction of the hydrogens with the solvent molecules. The intimate interaction that exists between the hydrogens of the imidazolium cation and the BF - 4 anion results in the BF - 4 salts being less solvated compared with salts containing BF - 6 and SbF - 6 anions. For imidazolium salts that contain C 2 H 5 , C 4 H 9 and C 8 H 1 7 side-chains bonded in the 1 and 3 positions, the interaction between H2 and the solvents was observed to be greater than for imidazolium salts with C 1 6 H 3 3 substituents. On the other hand, for imidazolium salts that have C 1 6 H 3 3 substituents the interaction between H2 and the solvents is similar to that for H4 and H5.
A facile method to deposit zeolites Y and L onto cellulose fibers

Abstract Zeolite (Y and L)/cellulose composites are synthesized from natural cellulose fibers pre-treated with NaOH, KOH or Na2SiO3, and preformed zeolite powders. Several techniques such as diffuse reflectance infrared spectroscopy, X-ray diffraction, scanning electron microscopy and BET specific surface area measurements were used to characterize these materials. Successful synthesis depends on extent of water removal from open reactors, fiber pre-treatment and reaction temperature, reaction time, and initial water:zeolite:fiber ratio. One important trait of the materials reported in this study is that their zeolite content becomes stable on washing with water at 373 K for several hours.