cssi/SciSciGPT-SciSciNet huggingface dataset:
Aeroelastic analysis of prop fan blades with a semiempirical dynamic stall model

The time-history response of a propfan wind-tunnel model with dynamic stall was studied analytically. The response obtained from the analysis was compared with available experimental data. The governing equations of motion were formulated in terms of blade normal modes calculated using the COSMIC-NASTRAN computer code. The response analysis considered the blade plunging and pitching motions. The lift, drag, and moment coefficients for angles of attack below the static stall angle were obtained from a quasi-steady theory. For angles above static stall angles, a semiempirical dynamic stall model based on a correction to the angle of attack was used to obtain lift, drag, and moment coefficients. Using these coefficients, the aerodynamic forces were calculated at a selected number of strips, and integrated to obtain the total generalized forces. The combined momentum-blade element theory was used to calculate the induced velocity. The semiempirical stall model predicted a limit cycle oscillation near the setting angle at which large vibratory stresses were observed in an experiment. The predicted mode and frequency of oscillation also agreed with those measured in the experiment near this setting angle. The results also correlated well with the other published data that used a semiempirical dynamic stall model based on a synthesized procedure.
Olfactory dysfunction and its measurement in the clinic and workplace.

Objectives: To provide an overview of practical means for quantitatively assessing the sense of smell in both the clinic and workplace. To address basic measurement issues, including those of test sensitivity, specificity, and reliability. To describe and discuss factors that influence olfactory function, including airborne toxins commonly found in industrial settings. Methods: Selective review and discussion. Results: A number of well-validated practical threshold and suprathreshold tests are available for assessing smell function. The reliability, sensitivity, and specificity of such techniques vary, being influenced by such factors as test length and type. Numerous subject factors, including age, sex, health, medications, and exposure to environmental toxins, particularly heavy metals, influence the ability to smell. Conclusions: Modern advances in technology, in conjunction with better occupational medicine practices, now make it possible to reliably monitor and limit occupational exposures to hazardous chemicals and their potential adverse influences on the sense of smell. Quantitative olfactory testing is critical to establish the presence or absence of such adverse influences, as well as to (a) detect malingering, (b) establish disability compensation, and (c) monitor function over time.
Michel Waisvisz: the man and the hands

Michel Waisvisz, electronic music impresario and dedicated inventor and performer, was the closing plenary speaker at CHI 2005. We were pleased to be able to interview him and we hope his life, his work, and his comments inspire you to follow his lead: Have vision, be fearless, experiment, play!
HALF DOSE DEXAMETHASONE IN THE TREATMENT OF BPD. 1129

A prospective nonrandomized trial was conducted to evaluate the benefit and the side effects of half of the standard dose of dexamethasone viz. 0.125mg/kg/dose q 12hrlv progressively tapered over a period of 21 days.Five prematures on mechanical ventilation(MV) were randomly enrolled with BW 810±184.22gms. and GA of 25.2±2.16 wks. Pretreatment oxygen, IMV and pressure (PIP/PEEP) requirements were 31.2±7.05%, 21.8±6.98bpm and 15.6±1.3/5 cm H2O respectively. All patients were extubated to NCPAP in 6.4±4.45days and were weaned off the MV in 10.4±6.91 days. The total number of days on oxygen before and after treatment were 28.2±12.47 and 24±15.7, and the total number of days on MV before and after treatment were 27.6±12.58 and 10.4±6.91 respectively. As regards treatment complications none off these patients manifested:1) hypertension.2) Hyperglycemia.3) GI bleed.4) Sepsis, one patient developed Z I stage II and III retinopathy of prematurity. Literature review revealed no therapeutic trial of Dexamethasone at this dosage.Comparing our data with historical controls we conclude prematures <1kg and GA<28wks can be successfully treated with half the standard dose of dexamethasone and with no complications.This finding deserve further evaluation in a prospective, case control and randomized manner. Table
Morphological analysis of pores in directionally freeze-cast titanium foams

Synchrotron x-ray tomography was performed on titanium foams with aligned, elongated pores, initially created by sintering directionally freeze-cast preforms using two different powder sizes. Three-dimensional reconstructions of the pore structures were analyzed morphologically using interface shape and interface normal distributions. A smaller powder size leads to more completely sintered titanium walls separating the dendritic pores, which in turn created a more compact distribution of pore shapes as well as stronger pore directionality parallel to the ice growth direction. The distribution of pore shapes is comparable to trabecular bone reported in the literature, indicating the foam’s potential as a bone replacement material.
Transcriptome profiling of Nasonia vitripennis testis reveals novel transcripts expressed from the selfish B chromosome, paternal sex ratio.

A widespread phenomenon in nature is sex ratio distortion of arthropod populations caused by microbial and genetic parasites. Currently little is known about how these agents alter host developmental processes to favor one sex or the other. The paternal sex ratio (PSR) chromosome is a nonessential, paternally transmitted centric fragment that segregates in natural populations of the jewel wasp, Nasonia vitripennis. To persist, PSR is thought to modify the hereditary material of the developing sperm, with the result that all nuclear DNA other than the PSR chromosome is destroyed shortly after fertilization. This results in the conversion of a fertilized embryo—normally a female—into a male, thereby insuring transmission of the “selfish” PSR chromosome, and simultaneously leading to wasp populations that are male-biased. To begin to understand this system at the mechanistic level, we carried out transcriptional profiling of testis from WT and PSR-carrying males. We identified a number of transcripts that are differentially expressed between these conditions. We also discovered nine transcripts that are uniquely expressed from the PSR chromosome. Four of these PSR-specific transcripts encode putative proteins, whereas the others have very short open reading frames and no homology to known proteins, suggesting that they are long noncoding RNAs. We propose several different models for how these transcripts could facilitate PSR-dependent effects. Our analyses also revealed 15.71 MB of novel transcribed regions in the N. vitripennis genome, thus increasing the current annotation of total transcribed regions by 53.4%. Finally, we detected expression of multiple meiosis-related genes in the wasp testis, despite the lack of conventional meiosis in the male sex.
The Parsonage Children: An Analysis of the Creative Early Years of the Brontës at Haworth

This paper analyzes the evolving creative development of the young Brontes at Haworth Parsonage in England during the first half of the nineteenth century. The author concludes that by closely examining the early years of eminent individuals we are better able to analyze those qualities, behaviors, and events that describe the process of talent development. In the case of the Brontes, one is able to study a family of exceptional talent and to reflect on the significance of the role of parents, collaborative siblings, and the natural environment in the nourishing and sustaining of that talent. This paper focuses on the education of the Brontes and on the "little books" that they started to produce in abundance when they were young and continued to write into adolescence.
Computer forensics, information security and law: a case study

Providing security and assurance to information systems and communications is one of the highest national priorities. It is our task to prepare computer information system security professionals with current security and assurance information to achieve this objective. To meet this urgent need, the faculty must have the knowledge and skills to be taught in the classroom. For several semesters, we have been developing information system security curriculum with a computer forensics course for the students. Active participation in real life security problems is a great opportunity to learn the subject matter. This paper describes one of our positive experiences.
The origin and survival of gastric parietal cells in the mouse

Using microradioautography, the origin of the gastric parietal (and zymogen) cells was deduced by observing the time of appearance of labelled parietal cells in relation to the other labelled cells in the gastric mucosa. In order to see whether the parietal cell divides in the adult mouse, time grain count curves of the labelled parietal cells were made from animals which were killed at 1–291 days after thymidine 3H injection DPT). Parietal cell survival was followed by observing the disappearance of the labelled parietal cell population. Parietal cells appear to be entirely derived from other cells since a significant number of labelled parietal cells does not appear unless the animal is allowed to survive for several days. Parietal cells do not appear unless the animal is allowed to survive for several days. Parietal cells do not seem to undergo mitosis in the adult mouse because the time grain count curves did not shift with time. Although a few labelled parietal cells persisted in the 291 DPT animals, a large majority of the labelled parietal cells disappeared by 90 DPT and had a half life of roughly 23 days. This suggests an element of renewal for the parietal cell population.
Characterisation of uveitis in patients with psoriatic arthritis

OBJECTIVE The purpose of this study is to describe the clinical characteristics of uveitis related to psoriatic arthritis (PsA), and also to compare the uveitis in PsA to the uveitis in spondyloarthropathy (SA). METHODS Sixteen patients with uveitis and PsA were evaluated in a tertiary care uveitis clinic. These patients were compared retrospectively to a series of 89 patients with uveitis and SA. RESULTS Eight (50%) of the 16 patients with uveitis had strictly peripheral arthritis, while two (12.5%) had axial only, and six (37.5%) had axial and peripheral arthritis. Patients with uveitis and axial disease were more likely to be male (100% v 38%) and HLA-B27 positive (6 of 6 typed positive v 0 of 3 typed positive) when compared with those with uveitis and peripheral arthritis only. Compared with patients with SA, those with PsA were more likely to have insidious onset (19% v 3%), simultaneously bilateral (37.5% v 7%), chronic duration (31% v 6%), or posterior (44% v 17%) uveitis. Complications of uveitis were similar in the SA and PsA groups. CONCLUSION Uveitis in patients with PsA was more likely to be insidious in onset, continuous, posterior, and active bilaterally compared with uveitis in patients with SA. Patients with uveitis and axial involvement were more likely to be male and HLA-B27 positive compared with patients with uveitis and peripheral arthritis alone. Patients with seronegative arthritis and uveitis that begins insidiously, lasts longer than six months, is bilateral, or is posterior, should be carefully questioned about the presence of either psoriasis or inflammatory bowel disease.
A model for the coupling of α‐helix and tertiary contact formation

Peptides corresponding to excised α-helical segments of natural proteins can spontaneously form helices in solution. However, peptide helices are usually substantially less stable in solution than in the structural context of a folded protein, because of the additional interactions possible between helices in a protein. Such interactions can be thought of as coupling helix formation and tertiary contact formation. The relative energetic contributions of the two processes to the total energy of the folded state of a protein is a matter of current debate. To investigate this balance, an extended helix-coil model (XHC) that incorporates both effects has been constructed. The model treats helix formation with the Lifson-Roig formalism, which describes helix initiation and propagation through cooperative local interactions. The model postulates an additional parameter representing participation of a site in a tertiary contact. In the model, greater helix stability can be achieved through combinations of these short-range and long-range interactions. For instance, stronger tertiary contacts can compensate for helices with little intrinsic stability. By varying the strength of the nonlocal interactions, the model can exhibit behavior consistent with a variety of qualitative models describing the relative importance of secondary and tertiary structure. Moreover, the model is explicit in that it can be used to fit experimental data to individual peptide sequences, providing a means to quantify the two contributions on a common energetic basis.
Commentary: Trailblazing a Research Agenda at the Interface of Pediatrics and Genomic Discovery—a Commentary on the Psychological Aspects of Genomics and Child Health

Unprecedented advances in human genome science are underway with potential to benefit public health. For example, it is estimated that within a decade, geneticists and epidemiologists will complete a catalog of the majority of genes associated with common chronic diseases. Such rapid advances create possibilities, if not the mandate, for translational research in how best to apply these and other anticipated discoveries for both individual and population health benefit. Driving these discoveries are rapid advances in infrastructure (e.g., the International HapMap Project to catalog human genetic variation; http://www.hapmap.org), analytical methods, and technology. This expansion in capabilities quickly has taken us from a genetics paradigm-where the influence of individual genes on health outcomes is paramount, to a genomics paradigm-where the complex influence of individual genes is considered in concert with each other and with environmental exposures on health outcomes. We discuss these and similar groundbreaking discoveries with an eye toward understanding their importance to child health and human development, and the role of behavioral science research conducted at the interface of pediatrics and genomic discovery.
Bovine Membrane-Type 1 Matrix Metalloproteinase: Molecular Cloning and Expression in the Corpus Luteum

Matrix metalloproteinase-2 (MMP-2) is produced as a zymogen, which is subsequently activated by membrane-type 1 metalloproteinase (MT1-MMP). The objectives of the present study were to clone bovine MT1-MMP and to investigate its expression in the corpus luteum. Corpora lutea were harvested from nonlactating dairy cows on Days 4, 10, and 16 of the estrous cycle (Day 0 5 estrus; n 5 3 for each age). The bovine MT1-MMP cDNA contained an open reading frame of 1749 base pairs, which encoded a predicted protein of 582 amino acids. Northern blotting revealed no differences (P . 0.05) in MT1MMP mRNA levels between any ages of corpora lutea. Western blotting demonstrated that two species of MT1-MMP, the latent form (;63 kDa) and the active form (;60 kDa), were present in corpora lutea throughout the estrous cycle. Active MT1-MMP was lower ( P , 0.05) in early stages of the corpus luteum than the mid and late stages, where MMP-2 activity, as revealed by gelatin zymography, was also elevated. Furthermore, immunohistochemistry revealed that MT1-MMP was localized in endothelial, large luteal, and fibroblast cells of the corpus luteum at different stages. Taken together, the differential expression and localization of MT1-MMP in the corpus luteum suggest that it may have multiple functions throughout the course of the estrous cycle, including activation of pro-MMP-2. corpus luteum, corpus luteum function, ovary
An Overview of the Orbiting Astronomical Observatory

The world's first Orbiting Astronomical Observatory, OAO-II, was launched by the U.S.A. on December 7, 1968. Over one year of operation has proven its design concepts and utility. Built in an octahedron shape, 10 feet by 7 feet, the satellite weighs 4400 pounds. Two experiments are located centrally within the space-craft, each viewing space from opposite ends. Both experiments contain multiple optical and detector systems for spectrophotometry and surveys in the ultraviolet spectrum. The design was dictated by the stringent requirements of the experiments for pointing accuracy (one minute of arc anywhere in the celestial sphere), pointing stability (five seconds of arc), command capability, data handling, thermal environment, and the constraints of the orbit for ground-station contacts. Six two-gimbal star trackers are programmed by the on-board memory to acquire and track appropriate guide stars. Error signals are generated which drive the reaction wheels to obtain stellar stabilization. Coarse momentum wheels are used for slewing the spacecraft. Memories permit storage of 200 000 bits of experimental data. All information is relayed to the central control station in Greenbelt, Md. OAO-II has shown that it is practical to maintain a continuous viewing capability in space for long periods of time so that fruitful astronomical experiments can be performed.
When States Fail: Causes and Consequences

When States Fail: Causes and Consequences. Edited by Robert I. Rotberg. Princeton: Princeton University Press, 2003. 336p. $65.00 cloth, $19.95 paper.Failed states have proliferated in the last 15 years. For much of this time Robert Rotberg has played a major role in defining debates about this development. His latest edited volume is a collection of 14 essays that examine why states fail and what to do about them once they fail. Most of the contributors are political scientists. A few are experts in conflict management and have worked directly in international efforts to remedy state failure.
Arming America: The Origins of a National Gun Culture

Michael A. Bellesiles's "Arming America is a stunning and seminal book that challenges everything we've previously been taught about America's history with guns. Painstakingly examining the historical record, Bellesiles shatters the myth of America's gun-toting revolutionary citizens. Beginning with the European tradition from which the American colonists emerged, Bellesiles indicates that ordinary people had virtually no access to or practical training in firearms. Bellesiles illustrates a dramatic surge of interest in hunting in the 1820s and 1830s on the part of urban middle- and upper-class men, and discovers that in the 30s the word "manly" increasingly became linked with gun use. By the mid-1850s technological advances had already contributed to an increase in gun manufacturing, but the Civil War encouraged industrialization and gun production as well. At the end of the war, the decision to allow soldiers to keep their weapons transformed the once seldom-needed tool to a perceived necessity, fostering an emotional connection between man and weapon. Given the ramifications of this book in the societal debate concerning gun control in America, many expressed outrage upon the book's initial publication by Knopf. When questions arose as to details of Bellesiles research, the politically motivated effort by the gun Iobby and its supporters expanded to include a committee of scholars and historians who devoted months to checking Bellesiles's footnotes in the archives where he did his research--a practice that is extremely unusual in historical scholarship--and cited evidence of lax research in several pages. In this revised edition, Bellesiles answers his academic critics, providingupdated research addressing their legitimate concerns, while finding that the underlying thesis of his book remains as solid as ever. Legal scholar and historian Richard B. Bernstein adds a foreword in which he examines the virulent power of the American Right to obliterate those voices which speak out in opposition to their own.
Symbiosis and Confirmation Between the Parents of the Schizophrenic

Parents of schizophrenics (N = 17) were compared with parents of nonschizophrenic hospitalized patients (N = 14) and parents of normals (N = 15) on the degree of symbiotic enmeshment and confirmation of individuality in the parental relationship. Symbiosis was divided into six component variables: undifferentiation, dependency, intervention, disapproval of other relationships, separation difficulty, and injunctions. Confirmation was bifurcated into acknowledgment and accommodation. Projective tests (TAT and Make-A-Picture-Story) and interviews were used to measure both variables. The results suggest that mothers of schizophrenics tend to be symbiotically attached to their husbands and view their husbands as forming the same type of attachment to them. Fathers of schizophrenics do not tend to be symbiotically involved with their wives but fail to confirm them. The implications of the results for the family system of the schizophrenic are discussed.
Transmission line approximation for periodic structures of dielectric bodies and its application to absorber design

The field quantities associated with a periodic structure can be written as a plane wave modulated by periodic vector functions. The combination of a formulation in terms of the averaged periodic functions and an effective material concept leads to a transmission line approximation (TLA). This method greatly simplifies the solution for scattering from periodic structures such as a microwave absorber and is useful for design purposes. The accuracy and limitations of TLA will be examined by comparison with the periodic moment method (PMM) for various design examples.
Monoclonal Antibody Studies of Drug Resistance

A major problem in the control of metastatic disease is the outgrowth of cells which display simultaneous resistance to a number of therapeutic drugs.1 This multidrug resistance (MDR) involves resistance to some of the most commonly used anticancer drugs. Several mammalian cell lines are available which model this human pleiotropic cross-resistance to chemotherapeutic 2–7 agents. These drug-resistant cell lines afford an in vitro system to study molecular mechanisms of resistance. Studies in such model systems indicate that reduced cellular accumulation of the affected drugs is a major factor, so that membrane alterations may be involved in drug resistance. In the wellcharacterized colchicine-resistant Chinese hamster ovary (CHO) system selected 3 by Bech-Hansen et al.,3 it is clear that multidrug resistance has a genetic basis. The degree of both drug resistance and reduced membrane permeability is correlated with the elevated expression of a plasma membrane glycoprotein with a molecular weight of 170,000 daltons, termed P-glycoprotein or P170.8–13 Recently, a 600-base pair (bp) complementary DNA (cDNA) encoding part of the P-glycoprotein was obtained from aλ gt 11 expression vector library of a multidrug resistant CHO cell line.12 Using this cDNA as a probe in Southern blot analyses, it was shown that P-glycoprotein gene sequences are conserved among hamster, mouse, and human DNA.
Wireless local positioning system via DS-CDMA and beamforming: a perturbation analysis

In this paper, we analyze the perturbation effects on the performance of a novel wireless local position system (WLPS) with applications in homeland security, defense, vehicle collision avoidance, and multi-robot collaboration and coordination. This WLPS has two main components: (1) a dynamic base station (DBS), and (2) a transponder (TRX), mounted at the monitoring and target mobiles, respectively. The DBS detects TRX via unique ID codes assigned to them. This structure leads to a unique wireless structure. In this work, we assume direct-sequence code division multiple access (DS-CDMA) transmission in the uplink (i.e., from TRX to DBS), and antenna array with conventional beamforming (BF) mounted at the DBS. This structure leads to a high probability-of-detection (POD) performance and capacity (in terms of number of TRX) at the DBS receiver. We analyze the effect of perturbations, which lead to antenna weight vector error, reduce the POD performance and the capacity of the WLPS system. Simulation are performed specifically for applications of WLPS systems in vehicle collision avoidance.
The Relation of Weight Stigmatization to Psychological Adjustment

This study investigated weight stigmatization as a predictor of adjustment in samples of 100 undergraduates and 99 bariatric patients. Coping strategies (emotion-focused coping, problem-focused coping, disengagement coping) were tested as moderators of this relation. Weight stigmatization predicted depression, anxiety, and antisocial behavior when controlling for the effects of stressful life events. Problem-focused coping weakened the association between weight stigmatization and depression. Emotion-focused coping augmented the relation between weight stigmatization and antisocial behavior. The results support weight stigmatization as a meaningful predictor of adjustment difficulties. Engendering a problem-focused coping style over an emotion-focused coping style might benefit patients reporting weight stigmatization. Further work is necessary to understand what specific elements of these coping styles impact adjustment.
Imbalance Response of a Test Rotor Supported on Squeeze Film Dampers

Squeeze film dampers (SFDs) provide vibration attenuation and structural isolation to aircraft gas turbine engines which must be able to tolerate larger imbalances while operating above one or more critical speeds. Rotor-bearing-SFD systems are regarded in theory as highly nonlinear, showing jump-phenomena and even chaotic behavior for sufficiently large levels of rotor imbalance. Yet, few experimental results of practical value have verified the analytical predictions. A test rig for measurement of the dynamic forced response of a three-disk rotor (45 kg) supported on two cylindrical SFDs is described. The major objective is to provide a reliable data base to validate and enhance SFD design practice and to allow a direct comparison with analytical models. The open-ends SFD are supported by four-bar centering structures each with a stiffness of 3.5 MN/m. Measured synchronous responses to 9,000 rpm due to various imbalances show the rotor-SFD system to be well damped with amplification factors between 1.6 and 2.1 while traversing cylindrical and conical modes critical speeds. The rotor amplitudes of motion are found to be proportional to the imbalances for the first mode of vibration, and the damping coefficients extracted compare reasonably well to predictions based on the full-film open-ends SFD. Tight lip (elastomeric) seals contribute greatly to the overall damping of the test rig. Measured dynamic pressures at the squeeze film lands are well above ambient values with no indication of lubricant dynamic cavitation as simple theoretical models dictate. The measurements show absence of non-linear behavior of the rotor-SFD apparatus for the range of imbalances tested.• The research program is a joint effort funded by the National Science Foundation (NSF) and the TAMU Turbomachinery Research Consortium (TRC).Copyright © 1997 by ASME
Early type I interferon response correlates with Borrelia burgdorferi dissemination in a mouse model of Lyme disease (INM3P.417)

Borrelia burgdorferi genotypes differ in their capacity to cause disseminated Lyme disease. Gene array analysis was employed to profile the host transcriptome induced by Borrelia genotypes in the blood of C3H mice during early dissemination following intradermal inoculation. The greatest responses were elicited by Borrelia turicatae , a relapsing fever spirochete that reaches high densities in the blood (313 entities; 170 induced, 143 repressed) and by B515, a B. burgdorferi clinical isolate that causes disseminated infection (129 entities; 52 induced, 77 repressed). Induced transcripts included IFN-responsive genes and genes involved in immunity and inflammation. B331, a B. burgdorferi clinical isolate that did not disseminate, stimulated changes in the fewest number of entities (1 induced, 4 repressed). Transcriptional regulation of type I IFN and IFN-related genes was measured by RT-PCR in mouse skin biopsies collected from the site of infection 24 hours after inoculation. The mean fold change values for Ifnb , Cxcl10 , Gbp1 , Ifit1 , Ifit3 , Irf7 , Mx1 , and Stat2 , were found to be significantly elevated in B515-infected mice relative to the control group. In contrast, transcription of these genes was not significantly changed in response to B331 or B31-4, a non-infectious B. burgdorferi mutant, although live B331 spirochetes could be recovered from skin. These results establish an association between B. burgdorferi genotype, dissemination, and early type I IFN induction.
The 'Wicked Problem Construct' as a Framework for Organizational Development and Change

The recognition of tensions, contradictions and paradoxes in theory, research, and practice within organizations is important for sustainable Organization Development and Change (OD&C). The extent to which organizations (public, private, and the third sector) currently have adequately come to terms with such complexity still remains open to discussion. The wicked problem construct (WPC) is a concept, process and a framework that can be used in identifying the reasons for these tensions and contradictions, explaining how they can be managed, and pointing out the limits they create for what is needed for organizational change and effectiveness. This paper examines the conceptual literature on ‘Wicked Problems’, identifying the critical dimensions of the proposed construct, and exploring the lack of attention to non-linear epistemology of practice of OD&C. The challenges of traditional OD approaches to address complexity and to increase effectiveness in dealing with wicked problems are explained.The implication for practice of the WPC as an OD&C framework for organizational effectiveness in public, private, and the third sectors is described.
Abstract 426: Blood Pressure Lowering Effect of Triamterene

Triamterene is a potassium-sparing diuretic, often used in combination with thiazide diuretics for treatment of hypertension. By inhibiting the epithelial sodium channel (ENaC) in collecting duct, ...
111In oxine-labeled rabbit platelets: in vivo distribution and sites of destruction

We have studied the kinetics, biodistribution, and fate of autologous platelets labeled with 111In-oxine in rabbits. The initial recovery was 75% and mean survival time was 2.8 days when the data were analyzed by the multiple-hit gamma function model. Using a modified geometric mean for correction of attenuation, there was good correlation between the values obtained by in vivo quantification and those obtained by postmortem measurements of the radioactivity in the liver and the spleen (i.e., r = 0.854 and 0.899, respectively, n = 32). Using this method, it was shown that after infusion, the 111In-platelets rapidly accumulated in these two organs reaching 35% and 12% of the injected dose in the liver and spleen, respectively, by 1 day. Thereafter, there was little subsequent change. On the sixth day, when essentially all of the 111In-platelets had cleared from the circulation, a total of 82% of the injected dose was deposited in the three major reticuloendothelial organs: liver (40%), spleen (14%), and bone marrow (28%). Our results suggest that in addition to liver and spleen, bone marrow played an important role in sequestering platelets in rabbits.
Data Clustering of Solutions for Multiple Objective System Reliability Optimization Problems

AbstractThis paper proposes a practical methodology for the solution of multi-objective system reliability optimization problems. The new method is based on the sequential combination of multi-objective evolutionary algorithms and data clustering on the prospective solutions to yield a smaller, more manageable sets of prospective solutions. Existing methods for multiple objective problems involve either the consolidation of all objectives into a single objective, or the determination of a Pareto-optimal set. In this paper, a new approach, involving post-Pareto clustering is proposed, offering a compromise between the two traditional approaches. In many real-life multi-objective optimization problems, the Pareto-optimal set can be extremely large or even contain an infinite number of solutions. Broad and detailed knowledge of the system is required during the decision making process in discriminating among the solutions contained in the Pareto-optimal set to eliminate the less satisfactory trade-offs and t...
Hydrostatic pressure studies of GaN/AlGaN/GaN heterostructure devices with varying AlGaN thickness and composition

GaN-based heterostructure devices are of interest for pressure and stress sensing applications due to their potential for use at high temperatures and in caustic environments. We have grown n-GaN/u-AlGaN/n-GaN heterostructure devices on sapphire substrates by organometallic vapor phase epitaxy (OMVPE) using the epitaxial layer overgrowth (ELO) method. The devices were fabricated with varying AlGaN layer thickness and composition. Current-voltage (I-V) characteristics were obtained to characterize the performance of these devices under hydrostatic pressures up to 500 MPa. For a fixed bias, the current was observed to decrease in magnitude with increasing hydrostatic pressure for all devices tested. The current modulation is attributed to piezoelectric effects. Specifically, the polarization charge densities at both GaN/AlGaN interfaces are sensitive to changes in the hydrostatic pressure, and these charges affect the shape of the potential barrier and the current. Changes in the AlGaN layer thickness and composition modify the interfacial polarization, with thicker AlGaN layers and higher Al content increasing the effect of pressure on the observed I-V characteristics. The decreases in current magnitude with increasing pressure are linear over the pressure range tested. In order to quantify the performance of these devices, we calculate a pressure gauge factor based on a normalized change in current divided by the change in pressure. Values obtained range from 0.1–1.0 GPa−1, consistent with our previously published results for a single device. In addition, the turn-on voltages under both forward and reverse bias conditions are observed to increase with increasing AlGaN layer thickness and composition, a result that agrees with our device model. These turn-on voltages are governed by different mechanisms in the forward and reverse bias directions. Under forward bias, the mechanism is a transition from a thermionic to a tunneling process. However, under reverse bias, the turn-on occurs when the total electric field changes sign in the AlGaN layer.
Dual shear plate power processor packaging design

The use of solar electric propulsion (SEP) for spacecraft primary propulsion imposes an extreme range of operational and environmental design requirements associated with the diversity of missions for which solar electric primary propulsion is advantageous. One SEP element which is particularly sensitive to these environmental extremes is the power processor unit (PPU) which powers and controls the electric ion thruster. An improved power processor thermal-mechanical packaging approach, referred to as dual shear plate packaging, has been designed to accommodate these different requirements with minimum change to the power processor design. Details of this packaging design are presented together with test results obtained from thermal-vacuum and structural-vibration tests conducted with prototype hardware.
Interactions of adenosine A1 and A2a receptors on renal microvascular reactivity.

Adenosine vasoconstricts preglomerular arterioles via adenosine A1receptors. Because adenosine also activates adenosine A2receptors, its overall renal vascular actions are complex and not fully und...
Coordination-Driven Self-Assembly of Fullerene-Functionalized Pt(II) Metallacycles

We report the facile synthesis of C60 functionalized A2D2 (A = acceptor and D = donor) metallacycles M1 and M2, using the insight from platinum(II)–pyridine coordination driven self-assembly in combination with organo-fullerene chemistry. Both supramolecular adducts are soluble in common organic solvents, which facilitates their structural characterization by multinuclear NMR spectroscopy, UV–vis spectroscopy, and electrospray ionization mass spectrometry.
Application of arterial spin labeling and intra-voxel incoherent motion imaging in preoperative glioma

Objective:To investigate the three-dimensional arterial spin labeling(ASL) and intra-voxel incoherent motion(IVIM) value in preoperative grading of cerebral glioma. Materials and Methods: Forty-five patients with glioma proved by pathology(26 cases of high grade glioma and 19 cases of low grade glioma) underwent 3D-ASL and IVIM-DWI examination.Cerebral blood flow(CBF) in the most obvious perfusion area of the solid part of tumor and also in the contralateral normal area were measured using cerebral blood flow map. By fitting double exponential model, got the fast ADC map. On 3D-ASL,the ADC value in the solid part of the tumor and also in the contralateral normal area of the same section were measured.Results: CBF ratios of the lesion and contralateral normal area in high and low grade gliomas were 3.11±1.45 and 0.86±0.28 respectively, the fast ADC value were 1.88±0.51 and 0.96±0.31 respectively. There was significant differences between the two groups(P0.05). Conclusion: 3D-ASL and IVIM techniques are safe and noninvasive methods to extract information of perfusion in gliomas and thus can be used as methods for determining the grade of gliomas before operation.
KrishnaCam: Using a longitudinal, single-person, egocentric dataset for scene understanding tasks

We record, and analyze, and present to the community, KrishnaCam, a large (7.6 million frames, 70 hours) egocentric video stream along with GPS position, acceleration and body orientation data spanning nine months of the life of a computer vision graduate student. We explore and exploit the inherent redundancies in this rich visual data stream to answer simple scene understanding questions such as: How much novel visual information does the student see each day? Given a single egocentric photograph of a scene, can we predict where the student might walk next? We find that given our large video database, simple, nearest-neighbor methods are surprisingly adept baselines for these tasks, even in scenes and scenarios where the camera wearer has never been before. For example, we demonstrate the ability to predict the near-future trajectory of the student in broad set of outdoor situations that includes following sidewalks, stopping to wait for a bus, taking a daily path to work, and the lack of movement while eating food.
O game The Sims como catalisador da aprendizagem tecnológica de meninas

Este artigo descreve como o jogo de computador The Sims e o mundo virtual Teen Second Life foram usados como pontos de partida para o desenvolvimento dos interesses e das capacidades de meninas em relacao as tecnologias de informacao. A trajetoria de uma menina e usada para ilustrar o modo como a experiencia com os games serviu de catalisador para promover sua paixao pelos computadores, envolveu-a em aprendizagens proativas e permitiu que ela passasse a ver a computacao como uma potencial escolha profissional. Discute-se o papel do reconhecimento publico, das comunidades de fas e das mudancas nas ecologias de aprendizagem nas familias em relacao a tecnologia de informacao e comunicacao. O artigo conclui identificando estrategias e perspectivas ligadas ao uso dos games na aprendizagem das meninas no campo da tecnologia. The Sims as a catalyst for girls' it learningAbstract This paper describes how the computer game The Sims and the virtual world Teen Second Life were used as starting points for developing girls’ interests in and capabilities with information technology. One girl’s learning trajectory is used to illustrate how gaming served as a catalyst for fostering her passion for computing, engaged her in sustained, proactive learning, and changed her view of computing as a potential career choice. The role of public recognition, fan communities, and changing family ecologies for IT learning are discussed. The paper ends with identification of strategies and issues related to the further use of games for girls’ IT learning.Keywords: Gender and education. Science and technology. Computer games. The Sims como catalizador para el aprendizaje de tecnologia de las ninas ResumenEste articulo describe como el juego de computadora The Sims y el mundo virtual Teen Second Life fueron utilizados como punto de partida para el desarrollo del interes y de las capacidades de las ninas en relacion a las tecnologias de la informacion. La trayectoria de una nina ilustra el modo como la experiencia con games sirvio de catalizador para estimular su pasion por las computadoras, la involucro en aprendizajes proactivos y le permitio que pasase a ver la computacion como una potencial eleccion profesional. Son discutidos el papel del reconocimiento publico, de las comunidades de fans y de los cambios en las ecologias familiares en el aprendizaje en tecnologia de la informacion y comunicacion. El articulo concluye identificando estrategias y perspectivas vinculadas al uso de los games en el aprendizaje de las ninas en el campo de la tecnologia.Palabras claves: Genero y educacion. Ciencia y tecnologia. Juegos de computadora.
Bladder Neck Contracture and Urethral Stricture as Complications of Renal Transplantation

AbstractFrom 1963 to July 26, 1974, 211 men underwent renal transplantation at our clinic. Urethral strictures were present prior to the initial transplant in 4 patients (1.8 per cent) and developed in the post-transplant period in 13 patients (6.1 per cent). Postoperative bladder neck contractures occurred in 2 patients (0.9 per cent).
Comparative pharmacokinetics of tobramycin and gentamicin.

Blood and urine concentrations of a new aminoglycoside, tobramycin, were compared with those of gentamicin after intravenous and intramuscular administration in healthy adult volunteers. Serum concentrations for the two antibiotics were the same after an intravenous infusion of 100 mg for the first haur (about 4.75 p.g per milliliter), during the steady state attained by infusing 30 mg per hour for the next 2 haurs (about 3.85 p.g per milliliter), and during the elimination phase after the antibiotics were stopped. After a single intramuscular injection of 100 mg, the blood level curves were equal and the peak concentrations at 20 to 45 minutes were the same as those obtained after intravenous infusion of the same dose for 1 hour. Between 80% and 90% of each of the two antibiotics was recovered in the urine within 24 hours. Plasma clearance was not significantly higher than renal clearance, and glomerular filtration seemed to be the main pathway of elimination. The two aminoglycosides had an apparent volume of distribution of about 30% total body weight. Each had a half-life of 2 hours.
Smoking topography in men and women with and without current depression: Findings from a 10-site clinical trial

Drug and Alcohol Dependence 156 (2015) e183–e245 e221 Financial Support: NIDA. http://dx.doi.org/10.1016/j.drugalcdep.2015.07.594 A longitudinal mediational study of the stability of alexithymia among alcohol treatment seekers Fred A. Thorberg1,3,∗, Ross M. Young4, Karen Sullivan4, Michael Lyvers2, Jason Connor5, Ernest P. Noble7, Edythe London7, Reidar Tyssen3, Gerald Feeney6 1 Natnl Centre Dual Diagnosis, Innlandet Hosp Trust, Hamar, Norway 2 Bond University, Gold Coast, QLD, Australia 3 University of Oslo, Oslo, Norway 4 Queensland University of Technology, Brisbane, QLD, Australia 5 University of Queensland, Brisbane, QLD, Australia 6 Princess Alexandra Hospital, Brisbane, QLD, Australia 7 University of California Los Angeles, Los Angeles,
MORAL OBLIGATION AND RELIGIOUS BELIEF

Rather than moving directly to engage specific moral controversies, I have thought it important to consider some fundamental grounding matters that shape our responses to those controversies, but are often not addressed frontally in public life. Chapters 3 through 7 attempt to do that, with subject-matter described in their titles.
Three-phase common mode inductor design and size minimization

Three-phase common mode (CM) inductors are widely used in electric motor drives as a means to limit ground current, shaft voltage, and electromagnetic interference emission. As the switching frequency of power converters keeps increasing with the help of high performance switching devices such as SiC MOSFETs, the role of CM inductors are becoming increasingly important. This paper presents a comprehensive analysis on the magnetic design and sizing of three-phase CM inductors. Analytical calculation of critical parameters such as leakage inductance, stray capacitance, flux density, and losses will be addressed in the paper. Design constraints that determine the size of magnetic cores will also be shown. Finally, a systematic design procedure that minimizes the CM inductor size will be proposed and verified.
Evaluation of the adjustable-speed pumped hydro storage in systems with renewable resources

With the fast expansion of renewable resources in power systems, there is a growing interest in using pumped hydro storage (PHS) to facilitate the integration of high levels of renewable resources. In this paper, two different PHS technologies are studied, namely the traditional fixed-speed technology and the adjustable-speed technology. Mathematical models are developed for the two types of PHS technologies. A two-step approach is proposed to evaluate and compare the capabilities of the two PHS technologies to provide regulation reserves. The proposed approach represents the scheduling and the deployment of regulation reserves. The case study shows that the adjustable-speed PHS is more effective than the fixed-speed PHS in balancing renewable uncertainties in power systems.
Learning and Collaboration in Physical Computing

My research expands our understanding of CS education in the context of physical computing. Specifically I examine how the tools used when creating physical computing projects affect how students work and learn. Using distributed cognition (DCog) within a classroom environment, I will investigate the effect that information representation has on students' conceptions of CS and electronics. These explorations will be complemented by an application of cognitive load theory (CLT) to understand the difficulty of physical computing tasks and the effect tools have on the load students experience. Completion of this work will uncover mistakes and misconceptions students have in physical computing and highlight ways to effectively design tools for novice learners.