cssi/SciSciGPT-SciSciNet huggingface dataset:
A search for interstellar CH3D: Limits to the methane abundance in Orion-KL

A search has been performed for interstellar CH3D via its J(K) = 1(0) - 0(0) transition at 230 GHz and its J(K) = 2(0) - l(0) and J(K) = 2(1) - 1(1) lines at 465 GHz using the NRAO 12 m and CSO 10 m telescopes towards Orion-KL. This search was done in conjunction with laboratory measurements of all three transitions of CH3D using mm/sub-mm direct absorption spectroscopy. The molecule was not detected down to a 3 sigma level of T(A) less than 0.05 K towards Orion, which suggests an upper limit to the CH3D column density of N less than 6 x 10(exp 18)/sq cm in the hot core region and a fractional abundance (with respect to H2) of less than 6 x 10(exp -6). These measurements suggest that the methane abundance in the Orion hot core is f less than 6 x 10-4, assuming D/H approximately 0.01. Such findings are in agreement with recent hot core chemical models, which suggest CH4/H2 approximately 10(exp -4).
Simple stochastic networks: Some problems and procedures

Abstract : The paper provides an analysis of 'stochastic networks,' that is networks whose underlying link times are expressed as random variables. Analytic and Monte Carlo methods for finding the distribution function (or parameters thereof) of the maximal time through such a network are discussed. The first section, which considers analytical procedures, emphasizes networks whose link times are given by probability functions from an exponential family. It is shown that the Markov property of the exponential distribution may be utilized to simplify analytic computations. In the second section Monte Carlo techniques are described which provide useful information on project completion time distributions. It is argued that these easily applied techniques are more economical (fewer computations are required) than naive simulation. Throughout the paper, we suggest a blending of the analytical and simulation procedures into an efficient overall method for studying stochastic networks. (Author)
Clinical Study of Dental Cements. VII. A Study of Bridge Retainers Luted with Three Different Dental Cements

In a clinical study of three luting cements, 547 bridges and 162 crowns were permanently cemented. Patients were recalled at 6-month intervals and the restorations were examined for looseness. A pattern of retainer type, cement type and retainer success was demonstrable.
Epidemiology of restless legs syndrome: A synthesis of the literature

Restless legs syndrome (RLS) has gained considerable attention in the recent years: nearly 50 community-based studies have been published in the last decade around the world. The development of strict diagnostic criteria in 1995 and their revision in 2003 helped to stimulate research interest on this syndrome. In community-based surveys, RLS has been studied as: 1) a symptom only, 2) a set of symptoms meeting minimal diagnostic criteria of the international restless legs syndrome study group (IRLSSG), 3) meeting minimal criteria accompanied with a specific frequency and/or severity, and 4) a differential diagnosis. In the first case, prevalence estimates in the general adult population ranged from 9.4% to 15%. In the second case, prevalence ranged from 3.9% to 14.3%. When frequency/severity is added, prevalence ranged from 2.2% to 7.9% and when differential diagnosis is applied prevalence estimates are between 1.9% and 4.6%. In all instances, RLS prevalence is higher in women than in men. It also increases with age in European and North American countries but not in Asian countries. Symptoms of anxiety and depression have been consistently associated with RLS. Overall, individuals with RLS have a poorer health than non-RLS but evidence for specific disease associations is mixed. Future epidemiological studies should focus on systematically adding frequency and severity in the definition of the syndrome in order to minimize the inclusion of cases mimicking RLS.
Internal Control Weakness and Cost of Equity: Evidence from SOXSection 404 Disclosures

Section 404 of the Sarbanes-Oxley Act (SOX) requires every company to report on the effectiveness of internal controls over financial reporting. Section 404 has arguably been the most controversial provision of SOX, with many registrants complaining that the high cost of compliance outweighs its benefits. In contrast, the SEC and others have argued that the Section 404 provisions are beneficial to the capital markets and will eventually reduce the cost of capital. In this paper, we examine the association between implied cost of equity and internal control effectiveness for firms that filed Section 404 reports with the SEC. We find marginally higher cost of equity for firms disclosing material weakness in internal controls than for a sample of firms disclosing no material weaknesses. The differences in cost of equity disappear after controlling for firm characteristics associated with firms disclosing material weaknesses. Overall, our results are consistent with internal control weakness identified under Section 404 not being directly associated, on average, with higher implied cost of equity.
Relaxing Incisions in Correction of Penile Deformity Due to Peyronie's Disease

AbstractPurpose: The use of tunica albuginea relaxing incisions, a common component of several operative techniques for correction of penile deformity due to Peyronie's disease, is reviewed.Materials and Methods: Of 93 operations performed for penile straightening 24 involved relaxing incisions with penile prosthesis implantation but no grafts and 69 involved autologous free grafts into relaxing incisions without use of an implant.Results: Relaxing incisions were uniformly effective in correcting penile curvature when used in conjunction with a prosthesis. When autologous grafts were used without an implant, more than 80 percent of the patients with dorsal or ventral bending had a good result, compared to only 17 percent with lateral bending.Conclusions: Relaxing incisions are an effective technique for changing the shape of the erect penis by altering the configuration of the tunica albuginea at maximal extension.
On stable numerical differentiation

Based on a regularized Volterra equation, two different approaches for numeri- cal differentiation are considered. The first approach consists of solving a regularized Volterra equation while the second approach is based on solving a disretized version of the regularized Volterra equation. Numerical experiments show that these methods are efficient and compete fa- vorably with the variational regularization method for stable calculating the derivatives of noisy functions.
Force on a circular cylinder in viscous oscillatory flow at low Keulegan—Carpenter numbers

This paper presents the in-line force coefficients for circular cylinders in planar oscillatory flows of small amplitude. The results are compared with the theoretical predictions of Stokes (1851) and Wang (1968). For two-dimensional, attached- and laminar-flow conditions the data are, as expected, in good agreement with the Stokes–Wang analysis. The oscillatory viscous flow becomes unstable to axially periodic vortices above a critical Keulegan–Carpenter number K (K = Um T/D, Um = the maximum velocity in a cycle, T = the period of flow oscillation, and D = the diameter of the circular cylinder) for a given β (β = Re/K = D2/vT, Re = Um D/v, and v = the kinematic viscosity of fluid) as shown experimentally by Honji (1981) and theoretically by Hall (1984). The present investigation has shown that the Keulegan—Carpenter number at which the drag coefficient Cd deviates rather abruptly from the Stokes—Wang prediction nearly corresponds to the critical K at which the vortical instability occurs.
Computers in service to libraries of the future

Automation activities in libraries have been undertaken with accelerating frequency over the past ten years. It is no longer uncommon to find successful projects in almost every type and size of library throughout the country. Libraries have demonstrated that they can develop and operate ordering and processing systems to control financial and bibliographic information at the time a new item is added to the collection. Book catalogs and other holdings lists are produced and distributed in many formats. Automated circulation control systems, particularly the data collection type, are widely accepted and functioning successfully.
Covariance transformations for flame-propagation modeling

The covariance transformation used in earlier theoretical studies of turbulent-flame and isothermal-front propagation is defined and mathematically derived. This transformation provides the covariance associated with fluctuations of a turbulent scalar or vector-component variable in terms of the statistical properties of another fluctuating scalar or vector-component variable when the Fourier transforms of the two variables in transverse-wave number and frequency space are linearly dependent. Key words: Covariance, turbulence, turbulent combustion, front propagation, flame propagation
Temporal bone histopathology 14 years after cytomegalic inclusion disease : a case study

Temporal bones were examined from a 14-year-old male who died of sequelae of congenital cytomegalic inclusion disease (CID). Cytomegalovirus (CMV) was not isolated from inner ear fluid or multiple systemic tissues at the time of death. Examination of temporal bones revealed chronic pathology of both cochlear and vestibular sensory and nonsensory tissues. Endolymphatic hydrops was observed in the basal turn of the cochlear duct, while Reissner's membrane was collapsed in the more apical turns. Strial atrophy and a loss of cochlear hair cells were observed along the entire length of the basilar membrane. Vestibular neuroepithelial regions were degenerated and fibrosis was seen within the vestibular perilymphatic tissue spaces, suggesting prior labyrinthitis within the perilymph compartment in addition to the more typical pattern of endolabyrinthitis associated with human CMV infection. Distention of the saccular membrane was evident. In both cochlear and vestibular tissues, there were isolated regions of calcifications that appeared characteristic to that reported in other organ systems of individuals with CID. Collectively, these chronic, pathological findings in this case of CID demonstrate more extensive injury than has been identified in the previously reported acute temporal bone pathology of CID.
CLINICAL INVESTIGATION OF PROLONGED INDUCED HYPOTENSION IN HEAD AND NECK SURGERY

SUMMARY Thirty patients undergoing radical surgery for cancer of the head and neck were subjected to deliberate hypotension (60–80 mm Hg) for an average period of 275 minutes. Ten patients undergoing surgery of similar magnitude but without controlled hypotension formed a control group. Hypotensive patients excreted significantly less urine during surgery. There were no discernible differences between groups in respect of pre- and postoperative haemoglobin levels, blood volumes, blood urea nitrogen or serum glutamic oxaloacetic transaminase values, electrocardiographic or chest radiographic appearances, or in arterial blood-gas analysis made during surgery. One death occurred in the hypotensive group. The authors conclude that more sensitive indices than those utilized are necessary to assess adequacy of perfusion during deliberate hypotension.
Interventional Optical Molecular Imaging Guidance during Percutaneous Biopsy

In the context of percutaneous biopsy, optical imaging probes could improve accuracy and decrease the risk of sampling error, which in turn would reduce the clinical concern of false-negative results after receiving benign biopsy findings.
Thyroid hormone controls the development of connections between the spinal cord and limbs during Xenopus laevis metamorphosis

During premetamorphic stages, Xenopus laevis tadpoles expressing either a dominant-negative thyroid hormone (TH) receptor or a type-III iodothyronine deiodinase transgene in the nervous system have reduced TH-induced proliferation in the spinal cord and produce fewer hindlimb-innervating motorneurons. During prometamorphic stages, innervation of the hindlimbs is reduced, and few functional neuromuscular connections are formed. By metamorphic climax, limb movement is impaired, ranging from uncoordinated leg swimming to complete quadriplegia. This phenotype is due to transgene action in the tadpole spinal cord. The requirement of TH for neurogenesis during premetamorphosis is the earliest TH-regulated process reported to date in the sequence of metamorphic changes in anurans. The muscle formed during limb growth was previously shown to be a direct target of TH control. Here, we show that the same is true of the development of spinal cord cells that innervate the limbs.
Simple and Rapid F+ Coliphage Culture, Latex Agglutination, and Typing Assay To Detect and Source Track Fecal Contamination

Simple, rapid, and reliable fecal indicator tests are needed to better monitor and manage ambient waters and treated waters and wastes. Antibody-coated polymeric bead agglutination assays can fulfill these needs and are inexpensive and portable for nonlaboratory settings, and their reagents can be stored at ambient temperatures for months. The goal of this study was to develop, optimize, and validate a rapid microbial water quality monitoring assay using F+ coliphage culture, latex agglutination, and typing (CLAT) to detect F+ coliphage groups with antibody-coated particles. Rapid (180 min) F+ coliphage culture gave comparable results to those with the 16- to 24-h culture time used in EPA method 1601 and was amenable to CLAT assay detection. CLAT was performed on a cardboard card by mixing a drop of coliphage enrichment culture with a drop of antibody-coated polymeric beads as the detection reagent. Visual agglutination or clumping of positive samples occurred in <60 seconds. The CLAT assay had sensitivities of 96.4% (185/192 samples) and 98.2% (161/164 samples) and specificities of 100% (34/34 samples) and 97.7% (129/132 samples) for F+ RNA and DNA coliphages, respectively. CLAT successfully classified F+ RNA coliphages into serogroups typically obtained from human (groups II and III) and animal (groups I and IV) fecal sources, in similar proportions to those obtained with a nucleic acid hybridization assay. This novel group-specific antibody-based particle agglutination technique for rapid and simple detection and grouping of F+ coliphages provides a new and improved tool for monitoring the microbiological quality of drinking, recreational, shellfishing, and other waters.
A constraint-based approach for specification and verification of real-time systems

We develop a general constraint logic programming (CLP) based framework for specification and verification of real time systems. Our framework is based on the notion of timed automata that have traditionally been used for specifying real time systems. In our framework, a user models the ordering of real time events as the grammar of a language accepted by a timed automata, the real time constraints on these events are then captured as denotations of the grammar productions specified by the user. The grammar can be specified as a Definite Clause Grammar (DCG), while the denotations can be specified in constraint logic. The resulting specification can hence be regarded as a constraint logic program (CLP), and is executable. Many interesting properties of the real time system can be verified by posing appropriate queries to this CLP program. A major advantage of our approach is that it is constructive in nature, i.e., it can be used for computing the conditions under which a property will hold for a given real time system. Our framework also suggests new types of formalisms that we call constraint automata and timed push down automata.
Health literacy: A primer for pharmacists

Purpose The literature surrounding health literacy and its importance in everyday practice are reviewed. Summary Health literacy includes a patient’s reading, writing, and numeracy skills, as well as his or her cultural experiences, understanding of health concepts and pathophysiology, and basic communication skills. Over one third of the American population lack the skills necessary to understand health information, make health care decisions, or follow medication instructions. Independent risk factors for low health literacy include poor socioeconomic status, ethnicity, older age, and limited education. Mounting evidence suggests that low health literacy leads to poor health outcomes, increased mortality, increases in health care costs, and poorly self-managed chronic diseases. Communication with a pharmacist to gain clarification of medication instructions is often the last opportunity to ensure that patients understand how to use their medications appropriately. Low health literacy is not always easily recognized, as patients use well-practiced coping mechanisms or avoidant behaviors. Clear communication strategies help patients become more involved in their care plans and increase positive interactions. Tools to assess health literacy have been developed and can be used by pharmacists to guide education and counseling. Advanced methods of written and oral communication should be used to improve patient comprehension and understanding. Conclusion Tools such as simple word-recognition tests or comprehensive tests of functional health literacy can be used in daily practice to assess patients’ health literacy. Being familiar with communication techniques such as the Indian Health Service, teach back, and Ask Me 3 can help facilitate individualized medication-related education and maximize patient comprehension.
Practical Aspects of Forecasting Severe Convection in the United States: Storm Evolution and Warning

In order to protect life and property, forecasts of severe convection are critical on short time and space scales (on the order of 1 hour or less and a few 10s of km or less). Accurate assessment of the environment and monitoring of high-resolution observational data, frequently focusing on radar-observed evolution, are essential in this process. In the United States, these short-term time and space scale forecasts are referred to as warnings and are prepared by local forecast offices of the National Weather Service, who have responsibility for forecasters on the order of 100,000 km2.
SOLID-STATE 2H NMR: OVERVIEW WITH SPECIFIC EXAMPLES

The value of high resolution (solution) NMR spectroscopy for investigating polymeric materials can be seen by the hundreds of applications and publications in this area each year. Owing to the sensitivity of chemical shifts to molecular bonding and stereochemistry, NMR can be used to look at polymer structure and tacticity, copolymer sequence distribution, and degree of branching.[1] Reaction mechanisms can be probed using isotopically labelled or natural abundance samples while NMR relaxation data can be related to polymer segmental motions.
Compressive Imaging using Random Active Illumination

We present experimental results to demonstrate a compressive imaging system based on the use of structured light. Illumination patterns are defined using binary-valued random vectors and reconstruction is done using projection onto convex sets.
Are family patterns related to the development of chronic back pain

of siblings and birth order as prognostic indicators for chronic back pain. The Hypochondriasis (Hs) and Hysteria (Hy) scales from chc MMPI were chosen as external measures of concurrent validity. These measures have been shown to be useful as prognostic signs regarding response to both medical treaunent of back pain (Wiltse & Rocchio, 1975) and psychological treaunent of operant components of back pain (Sternbach, 1974). The subjects were 56 pacients at Duke University Medical Center (the same setting in which Gentry, et al. conducted their study) who had been referred for psychological evaluations after an orthopaedic surgeon or neurosurgeon had made a diagnosis of "chronic back pain." There were 29 males amd 27 females. Their mean age was 50.68 yr. All evaluations were done in 1977. Pearson product-moment correlations (Hays, 1963) were computed between Hypochondriasis scores and number of siblings (-.1629), between Hypochondriasis scores and birth order (.0778), between Hysteria scale scores and number of siblings ( -.I917 ), and bemeen Hysteria scale scores and birth order (-.0972). None of the correlations was significant (all ps > .05 ) . The results tend not to support the concurrent validity of number of siblings and birth order as prognostic indicators regarding chronic back pain. Therefore, it might be well for the clinician to use some circumspection in interpreting such data in cases of chronic back pain. However, the present study did not directly address the issue of predictive validity of the measures. It might be helpful to investigate the relationship of such family variables to length of time in recovery from back surgery, postoperative activity levels, etc. It is also possible that, while such variables may not by themselves have a significant psychosomatic impact, they m~ght have such an impact when interacting with other factors, such as marital status, age at the time of marriage, current size of family, presence of familial models for pain behavior, etc. In addition to descriptive studies like that of Gentry, et d., more systematic srud~es Including inferential statistics are needed.
Predicting parental monitoring behaviours for sugar-sweetened beverages in parents of school-aged children: An application of the Integrative Behavioural Model

Objective:The objective of this study was to identify theory-based psychosocial and environmental determinants of parental monitoring practices related to child sugar-sweetened beverage consumption...
Measures of Student Non-cognitive Skills and Political Tolerance after Two Years of the Louisiana Scholarship Program

This report examines the short-term effects of the Louisiana Scholarship Program (LSP) on students’ non-cognitive skills and civic values. While a growing number of studies have evaluated K-12 school voucher programs along academic dimensions, few have focused on the development of non-cognitive skills and civic values. This study aims to address that gap by providing the first analysis of differences in self-reported measures of grit, locus of control, self esteem, and political tolerance associated with the LSP. Using results from a phone survey of applicants to the program, we find little evidence of differences between LSP scholarship recipients and non-recipients. Nevertheless, diagnostics assessing the precision of our instruments to detect differences between subjects indicate that several of the scales measuring non-cognitive skills performed poorly in our sample. Moreover, our relatively low survey response rate of 11 percent raises concerns about the representativeness of our sample. Given these issues, we caution that our results are best understood as descriptive and not necessarily conclusive: they do not represent reliable estimates of the causal impact of the LSP on student non-cognitive skills and political tolerance.
Occupational Diseases in Chengdu,2007-2010

Objective To provide evidence for the development of occupational diseases prevention and control measures by understanding the regular pattern and characteristics of occupational diseases incidence in Chengdu.Methods Comprehensive analysis was conducted with the statistical analysis function in the "health hazards monitoring information system".Differences between proportions in different years were compared by using the exact test.Results Totally 271 cases of occupational diseases were confirmed in Chengdu during 2007-2010,in which pneumoconiosis accounted for 84.13%,chronic occupational poisoning accounted for 9.96%,occupational diseases due to physical factors accounted for 2.95%,and acute occupational poisoning accounted for 2.58%;cases in coal,railway,construction,machinery industry accounted for 47.60%,12.55%,8.12% and 7.38% respectively.Conclusion Pneumoconiosis is the main occupational disease in Chengdu,with the characteristic of high hazards in organic solvents.High-risk industries of occupational hazards are mainly at coal,railway,construction,light industry,machinery,chemicals,electronics,building materials,transportation,etc.
Diagnosis of diseases of the gall bladder.

Summary An attempt has been made to emphasize the important diagnostic aspects of the clinical picture of symptomatic cholelithiasis and the roentgen and laboratory procedures that are useful in confirming the diagnosis. In addition, brief reference is made to the clinical pictures and procedures used in confirming the diagnosis of acute cholecystitis, cholesterosis, and carcinoma of the gall bladder.
The Tolerant Coast

Land uses readings of Lawrence Durrell, Amos Oz and Jacqueline Shohet Kahanoff to introduce the concept of coastal exceptionalism. The tolerant coast may be a utopian space, a permissive arena for expatriate Europeans, a zone of nostalgia, or a centre of synergy. The chapter examines the examples of the Levant and the West Coast of the United States in some detail. The belief that there is a specific local quality that makes port towns uniquely tolerant places offers an interesting counterpoint to recent debates about the universal values of cosmopolitanism, multiculturalism and superdiversity. Land concludes with a discussion of Steve Jobs and Silicon Valley as a coastal expression of Saskia Sassen’s neoliberal global city, both hosting innovative firms and marketing themselves as stylish and transgressive.
Helping early childhood educators to understand and assess young children’s mathematical minds

This issue of ZDM Mathematics Education focuses on the formative assessment of young children’s mathematical thinking, with an emphasis on computer-based approaches drawing upon on cognitive and educational research. The authors discuss several different assessment methods, including clinical interviewing, observation, and testing, that are appropriate for children from about 3–8 years of age, and that can provide information useful for the improvement of teaching. This paper begins with a discussion of principles underlying this work and then introduces the paper topics and authors. The paper concludes by projecting a future in which professional development provides a sound basis for formative assessment; in which formative assessment is central to education; and in which the need for standard achievement tests is largely eliminated.
Game-Mechanics Reasoning for Automated Design Support

Videogame design fundamentally involves engineering interactive rule systems: a game designer combines a set of game mechanics such that, when they interact with each other and with the player’s actions, they produce the desired gameplay. Game designers typically prototype these rule systems to understand how they operate. Prototypes range from paper versions, in which a stripped-down form of the game’s rule system is simulated manually, to playable, implemented versions, which can be played by the designer and others to get feedback on gameplay ideas or discover problems. This thesis proposes that a number of the design questions such prototypes try to answer can be answered automatically. The ultimate design questions are mainly subjective: is the game interesting, fun, challenging, balanced, etc.? However, much prototyping gets at these issues indirectly by asking objective questions that help the designer understand how their rule system operates; the objective kinds of questions are amenable to automated reasoning, since they have answers that depend solely on the game’s formal rule system. By answering them automatically, we can speed up the design loop by allowing designers to quickly understand how their rule system is operating, getting much more factual understanding of the system that they can use in their subjective design thinking.
Treatment satisfaction of home-based telehealth versus in-person delivery of prolonged exposure for combat-related PTSD in veterans:

IntroductionAlthough there is growing support that evidence-based psychotherapies (EBPs) delivered in-person and through telehealth are equivalent in terms of symptom reduction for posttraumatic stress disorder (PTSD), there has been far less investigation comparing these treatment modalities in terms of patient satisfaction. The present study investigated participant satisfaction and perception of the quality of service delivery within a clinical trial comparing the delivery of an EBP, Prolonged Exposure (PE) for PTSD, through home-based telehealth and in-person services.MethodsVeterans (N = 67) with PTSD were randomized to receive PE via video telehealth technology (n = 27) or via in-person delivery (n = 40). Participants completed service demographic questions, PTSD symptom assessments, and satisfaction and service delivery perception questionnaires.ResultsAnalyses of covariance were used to investigate the influence of treatment modality on patient satisfaction and perceived quality of service deliver...
An evidence-based approach to treatment of open bite and deep bite: case reports.

Aim Evidence-based decision making is gaining increased emphasis in medicine and dentistry. Since orthodontics is both an art and a science, not all decisions can be based solely on scientific findings. However, to the extent that orthodontics is a science and is based on the principles of scientific method, the clinician can practice evidence-based decision making. This article summarizes the results of 6 case-controlled studies on treatment changes in deep bite or open bite. Material and methods All studies used the Bolton Brush Growth Study as a source for untreated controls. Strategies for correction of deep bite included cervical pull headgear, bionator therapy, and Tweed edgewise mechanotherapy. Open-bite strategies included 4 premolar extraction, 4 first molar extraction, and active vertical corrector therapy. The changes in 6 variables involved in overlap of the incisor teeth (changes in the maxilla and mandible, as well as tipping and bodily movements of the maxillary and mandibular incisors) were summed at the occlusal plane. Results Extraction of permanent teeth influences vertical facial growth, growth of the mandible is a major factor in the correction of deep bite, and tipping of the incisor teeth is an important contributor to open-bite correction. Two clinical cases that demonstrate the application of this analysis are presented. The first case involves an open bite treated with extraction of 4 premolars, and the second is a nonextraction deep-bite case treated with a Herbst appliance, followed by fixed appliances. Conclusion Case-controlled studies can help practitioners decide among various treatment strategies for vertical overbite problems.
Proteomic Identification of TAL1/SCL-Interacting Proteins: ETO-2 and MTGR1 Interact with TAL1 in Erythroid Progenitors.

Abstract The TAL1/SCL gene, originally identified from its involvement by a recurrent chromosomal translocation in T-cel acute lymphoblastic leukemia, encodes a basic helix-loop-helix (bHLH) transcription factor essential for hematopoietic and vascular development. Although TAL1 is believed to regulate transcription of specific sets of target genes, the mechanisms underlying TAL1-directed gene expression are poorly understood. Previous studies have shown, in fact, that it can act as either an activator or repressor depending on the coregulator(s) with which it interacts. To comprehensively identify TAL1's interaction partners in erythroid cells, we stably expressed a tandem epitope-tagged mouse TAL1 protein in murine erythroleukemia (MEL) cells and determined the composition of affinity-purified TAL1-containing complexes by multidimensional mass spectrometry. From this analysis, we identified all known members of a TAL1-containing DNA binding complex previously characterized in erythroid cells, including TAL1, its E protein DNA-binding partners, the zinc finger transcription factor GATA-1, the LIM-only protein LMO2, and the LIM domain-binding protein Ldb1, as well as proteins described to interact with GATA-1 (FOG-1), LMO2 (ELF2A2), and Ldb1 (SSDP2 and SSDP3). In addition, we identified a number of other DNA binding proteins, chromatin modifying proteins, and transcriptional regulators, including the ETO family members ETO-2 and MTGR1. TAL1 interaction with ETO-2 and MTGR1 was verified by coimmunoprecipitation analysis in MEL cells expressing these proteins at endogenous levels, in MEL cells stably expressing an epitope-tagged TAL1 protein, and in COS cells transiently transfected with TAL1 and ETO-2 or MTGR1 expression vectors. Mapping analysis with GAL4 fusion proteins identified the bHLH domain as the region in TAL1 responsible for interaction with these ETO family proteins. Significantly, expression of MTGR1 enhanced ETO-2 interaction with TAL1-GAL4 protein. Finally, transient transfection analysis with a luciferase reporter construct linked to multiple GAL4 DNA binding sites showed greater than additive augmentation of TAL1-directed gene repression with coexpression of the two ETO-related proteins compared to that observed with ETO-2 or MTGR1 transfected individually. These results identify ETO-2 and MTGR1 as authentic TAL1 interacting proteins and suggest that a hetero-oligomeric complex of the two contributes to TAL1-directed repression in erythroid progenitors.
Subcellular electrode arrays for multisite recording of dopamine in vivo

We report the fabrication and use of carbon fiber (CF) arrays with 8 recording electrodes having individual diameters of 8–10 μm (9–10 times smaller than conventional sensors and state of art) for electrochemical recording of dopamine from deep brain regions in a minimally invasive and high density manner. Accordingly, key advancements demonstrated are (1) radical reduction in size and (2) potential for wide spatial distribution of concurrent electrochemical measurement in the brain.
Accuracy of finite-difference harmonic frequencies in density functional theory

Analytic Hessians are often viewed as essential for the calculation of accurate harmonic frequencies, but the implementation of analytic second derivatives is nontrivial and solution of the requisite coupled-perturbed equations engenders a sizable memory footprint for large systems, given that these equations are not required for energy and gradient calculations in density functional theory. Here, we benchmark the alternative approach to harmonic frequencies based on finite differences of analytic first derivatives, a procedure that is amenable to large-scale parallelization. Not only for absolute frequencies but also for isotopic and conformer-dependent frequency shifts in flexible molecules, we find that the finite-difference approach exhibits mean errors < 0.1 cm−1 as compared to results based on an analytic Hessian. For very small frequencies corresponding to nonbonded vibrations in noncovalent complexes (for which the harmonic approximation is questionable anyway), the finite-difference error can be larger, but even in these cases the errors can be reduced below 0.1 cm−1 by judicious choice of the displacement step size and a higher-order finite-difference approach. The surprising accuracy and robustness of the finite-difference results suggests that availability of the analytic Hessian is not so important in today's era of commodity processors that are readily available in large numbers. © 2017 Wiley Periodicals, Inc.
Whose East German Art is This? The Politics of Reception after 1989

Abstract | Beginning with an overview of painting in East Germany, this article examines the German-German Bilderstreit (image battle) of the long 1990s and two major art exhibitions in the new millenium, Kunst in der DDR (Art in the GDR, 2003) and Abschied von Ikarus(Farewell to Icarus, 2012-13). It ultimately argues that the history of East German art has been rewritten since unification in ways that reflect Western expectations and desires more than socialist realities, and shows how art historians, scholars of the German Democratic Republic (GDR, or East Germany), and those seeking alternatives to the neoliberal present can benefit from a less biased view. Resume | Commencant par un resume de la peinture en Allemagne de l’Est, cet essai examine la bataille de l’image allemande-allemande dans des longues annees 1990 et deux grandes expositions d’art dans le nouveau millenaire, Kunst in der DDR (L’Art en la RDA, 2003) et Abschied von Ikarus (Adieu a Icarus. 2012-13). Il fait valoir en fin de compte que l’histoire de l’art est-allemand a ete reecrit depuis l’unification d’une maniere qui reflete les attentes et desirs occidentales plus des realites socialistes, et montre comment les historiens de l’art, les chercheurs de la RDA, et ceux qui cherchent des alternatives au present neoliberaux peuvent beneficier d’une perspective moins prejuge.
Different Tales of John Glasgow: John Brown’s Evolution to Slave Life in Georgia

This article seeks to advance conversation on the literary and political agency of fugitive slave narrators and their far-reaching archival footprints by focusing on the evolution of John Brown’s n...
Two-Dimensional Material-Reinforced Separator for Li–Sulfur Battery

Li–S batteries are heavily researched as they are capable of meeting the demands of electrification of transport systems, provided their inherent polysulfide shuttling can be prevented to enhance t...
Effect of the Head Computed Tomography Choice Decision Aid in Parents of Children With Minor Head Trauma: A Cluster Randomized Trial

Importance The Pediatric Emergency Care Applied Research Network prediction rules for minor head trauma identify children at very low, intermediate, and high risk of clinically important traumatic brain injuries (ciTBIs) and recommend no computed tomography (CT) for those at very low risk. However, the prediction rules provide little guidance in the choice of home observation or CT in children at intermediate risk for ciTBI. Objective To compare a decision aid with usual care in parents of children at intermediate risk for ciTBI. Design, Settings, and Participants This cluster randomized trial was conducted in 7 geographically diverse US emergency departments (EDs) from April 1, 2014, to September 30, 2016. Eligible participants were emergency clinicians, children ages 2 to 18 years with minor head trauma at intermediate risk for ciTBI, and their parents. Interventions Clinicians were randomly assigned (1:1 ratio) to shared decision-making facilitated by the Head CT Choice decision aid or to usual care. Main Outcomes and Measures The primary outcome, selected by parent stakeholders, was knowledge of their child’s risk for ciTBI and the available diagnostic options. Secondary outcomes included decisional conflict, parental involvement in decision-making, the ED CT rate, 7-day health care utilization, and missed ciTBI. Results A total of 172 clinicians caring for 971 children (493 decision aid; 478 usual care) with minor head trauma at intermediate risk for ciTBI were enrolled. The patient mean (SD) age was 6.7 (7.1) years, 575 (59%) were male, and 253 (26%) were of nonwhite race. Parents in the decision aid arm compared with the usual care arm had greater knowledge (mean [SD] questions correct: 6.2 [2.0] vs 5.3 [2.0]; mean difference, 0.9; 95% CI, 0.6-1.3), had less decisional conflict (mean [SD] decisional conflict score, 14.8 [15.5] vs 19.2 [16.6]; mean difference, −4.4; 95% CI, −7.3 to −2.4), and were more involved in CT decision-making (observing patient involvement [OPTION] scores: mean [SD], 25.0 [8.5] vs 13.3 [6.5]; mean difference, 11.7; 95% CI, 9.6-13.9). Although the ED CT rate did not significantly differ (decision aid, 22% vs usual care, 24%; odds ratio, 0.81; 95% CI, 0.51-1.27), the mean number of imaging tests was lower in the decision aid arm 7 days after injury. No child had a missed ciTBI. Conclusions and Relevance Use of a decision aid in parents of children at intermediate risk of ciTBI increased parent knowledge, decreased decisional conflict, and increased involvement in decision-making. The intervention did not significantly reduce the ED CT rate but safely decreased health care utilization 7 days after injury. Trial Registration ClinicalTrials.gov Identifier: NCT02063087
Informed consent content in research with survivors of psychological trauma

One hundred eighty trauma-focused dissertations published in the United States were examined to determine the variation in risk language used in the informed consents. Level of risk proposed in the...
Case 2: Severe Hyperammonemia in a Neonate: An Alternate Ending.

A male infant is born at 38 weeks 3 days of gestational age to a gravida 5, para 1 woman via spontaneous vaginal delivery, after a pregnancy complicated by maternal preeclampsia. Maternal history is significant for 2 early miscarriages and an ectopic pregnancy. All prenatal laboratory findings, including maternal immunoglobulin G for herpes simplex virus (HSV), had been normal or negative. The family history is unremarkable. The infant requires normal newborn care and is discharged from the hospital on day 2 after birth. His parents note that he had been sleepy and a poor feeder. He is hypothermic and tachypneic at his first newborn visit to the pediatrician and is immediately referred to the emergency department. Septic evaluation reveals HSV in both serum and cerebrospinal fluid. Ammonia concentration is normal and his complete blood cell count reveals leukopenia. Initial treatment includes acyclovir, cefotaxime, and ampicillin, narrowed within 48 hours to acyclovir monotherapy. His condition rapidly declines and he develops respiratory failure on hospital day (HOD) 1. The ammonia concentration is within the normal range (39 μg/dL [28 μmol/L]). Feeding is initiated on HOD 2 with a subsequent rise in the ammonia concentration (113 μg/dL [81 μmol/L]). Despite the cessation of feeding and initiation of moderate glucose infusion rate, the ammonia concentration rises to 538 μg/dL (384 μmol/L) by HOD 4. The patient is transferred to a different hospital for metabolic consultation. Increased glucose …
Abstract WP459: The Impact of Patient Demographics and Comorbidities on Inpatient Mortality After Intracerebral Hemorrhage

Objective: To observe for trends in the inpatient mortality rate following nontraumatic intracerebral hemorrhage (ICH) and to determine the effect of pertinent comorbidities on inpatient mortality ...
Online Deep Learning in Wireless Communication Systems

We consider the problem of optimal power allocation in wireless fading channels. Due to interference, this problem is non-convex and challenging to solve exactly. The resemblance of this problem to a statistical loss problem motivates the use of a learning parameterization of the power allocation function. In particular, we use deep neural networks (DNNs) to represent the power allocation and develop a primal-dual learning method to train the weights of the DNN. Because the channel and capacity models may not be known in practice, we extend the learning algorithm to permit stochastic online operation, in which gradients are approximated by sampling. We demonstrate in a series of numerical simulations the performance of the proposed online primal-dual learning method in training a DNN-parameterization relative to a well-known heuristic benchmark.
Mentorship of Women in Academic Medicine: a Systematic Review.

Women remain underrepresented in academic medicine, particularly in leadership positions. This lack of women in leadership has been shown to have negative implications for both patient care and educational outcomes. Similarly, the literature demonstrates that female physicians are less likely to have mentors, despite the proven benefits of mentorship for career advancement. The objective of this review is to identify and describe models of mentorship for women in academic medicine. We searched PubMed, PsycINFO, Education Resources Information Center, and Cochrane Databases of Systematic Reviews following PRISMA guidelines in June 2017. We included original English language studies that described a mentorship program in the USA that involved academic medical doctorates and that were created for women or provided results stratified by gender. Our search returned 3625 results; 3309 references remained after removal of duplicates. Twenty articles met inclusion criteria. The majority of the programs were designed for junior faculty and used the dyad model of mentoring (i.e., one mentor/one mentee). Frequently cited objectives of these programs were to improve scholarship, promotion, and retention of female faculty. Program evaluations were primarily survey-based, with participant-reported satisfaction being the most frequent measured outcome. Most results showed very high satisfaction. Gender concordance between mentor and mentee did not impact satisfaction. Eight articles reported objective outcomes, including publications, retention, and promotion, and each of these demonstrated an improvement after program implementation. Our review suggests that mentorship programs designed for women, regardless of the model, are met with high satisfaction and can help promote and retain women in academic medicine. No clear best practices for mentorship emerged in the literature. Institutions, therefore, can individualize their mentorship programs and models to available resources and goals. These results demonstrate the importance of more widespread implementation of mentorship programs to more effectively facilitate professional development and success of women in academic medicine.
Exponentially harmonic maps, Morse index and Liouville type theorems

We obtain a result on the Morse index of an exponentially harmonic map from a Riemannian manifold into the unit n-sphere. Next, we prove a Liouville type 1 theorem for exponentially harmonic maps between two Riemannian manifolds. Finally, let $$(M, g_0)$$ be a complete Riemannian manifold with a pole $$x_0$$ and (N, h) a Riemannian manifold, under certain conditions we establish a Liouville type 2 theorem for exponentially harmonic maps $$f:(M, \rho ^2 g_0)\rightarrow N$$ , $$0< \rho \in C^\infty (M)$$ .
Pediatric oncology provider perspectives and practices: Supporting patients and families in schooling after cancer diagnosis.

BACKGROUND Cognitive limitations are common after childhood cancer and require assessment and support in the medical and school setting. Pediatric oncology providers are tasked with educating families about the side effects of disease/treatment, and supporting families as they navigate the associated challenges. Despite this important role, little is known about the training, practice, and knowledge of providers in the domain of cognitive/school impacts. METHODS An online survey was emailed to Children's Oncology Group (COG) member physicians in the United States. The survey consisted of 42 questions about training and practice, and 4 knowledge questions about neurocognitive impacts and school supports. RESULTS Surveys were completed by 282 physicians representing 64% of COG institutions and a diverse group of experience and institution size. The pediatric oncologist was reported most frequently (93%) as the person at their institution to provide information to families on this topic, yet 54% reported receiving no specific training in this area and the majority (66%) reported to only "somewhat" understand the issues pediatric oncology patients face when returning to school. A minority reported available institutional guidelines (42%) or screening tools (19%) to assist in making referrals or assessments. Knowledge questions concerning health conditions qualifying children for school supports received the fewest correct answers. The majority (77%) thought more training would be helpful. CONCLUSIONS Additional training about cognitive impacts and schooling challenges associated with childhood cancer is needed to prepare providers to support parents/children. In addition, establishing policy guidelines and screening procedures may help support providers in providing care.
Mapping socio-spatial constructions of normalcy: whiteness and ability in teacher candidates’ educational trajectories

In this paper I present a qualitative study in which I investigated how socio-spatial dimensions of schooling influenced the ways four, white, nondisabled teacher candidates made meaning of whitene...