cssi/SciSciGPT-SciSciNet huggingface dataset:
Rotor Boundary Layer Response to an Impinging Wake

This paper presents results of an experimental investigation on the response of a rotor boundary layer to an impinging Inlet Guide Vane (IGV) wake. High resolution two-dimensional Particle Image Velocimetry (PIV) measurements are conducted in a refractive index matched facility that provides an unobstructed view of the entire flow field. Data obtained at four different rotor phases, as the wake is chopped and passes by the rotor blade, allows us to examine the response of the rotor boundary layer to the mean flow and turbulence associated with the impinging wake. We focus on the suction side boundary layer in regions with adverse pressure gradients, from mid chord to the trailing edge. The phase-averaged velocity profiles are used for calculating the momentum and displacement thicknesses of the boundary layer, and for estimating the pressure gradients along the wall. Distributions of Reynolds stresses are also provided. The phase-averaged velocity profiles in the rotor boundary layer vary significantly with phase. During wake impingement the boundary layer becomes significantly thinner and more stable compared to other phases at the same location. Analysis of the possible causes for this trend suggests that the dominant contributors are unsteady, phase-dependent variation in pressure gradients along the wall.Copyright © 2004 by ASME
Community-based Quality of Life Indicators: A Service-Learning Exercise in a Graduate Statistics Class

The article describes the application of a service-learning strategy to a graduate statistics course. Employing a framework drawn from an emerging servicelearning canon, the author examines course design and implementation and identifies key outcomes and concludes that service-learning can contribute in a significant way to the contribution statistics courses can make to MPA programs. Statistics courses are rarely popular in graduate public administration programs. Few students enter MPA programs with strong backgrounds in quantitative analysis. Some even question the relevance of statistics to their professional work. As a result, those who teach statistics are often challenged to go beyond the formal presentation of various methods and analytic tools. They may be asked to defend the utility of the various univariate, bivariate, and multivariate techniques that make up a statistics curriculum. This, in turn, can lead to a search for innovative strategies through which to teach statistics. Reflecting this view, Jody Fitzpatrick (2000) has argued for a dramatic rethinking of the strategies used in teaching statistics in MPA curricula. In place of the technique-by-technique method typically employed, she recommends a hands-on approach that can better prepare students to initiate and use research in addressing public management and public policy concerns. More specifically, Fitzpatrick promotes the extensive reading of research and recommends that we assist students in becoming better "consumers of research." Like Fitzpatrick, faculty members in the School of Public and Environmental Affairs at Indiana University Northwest were looking, in 2002, for a way to make the study of statistics more meaningful to students. Service-learning, rather than the more extensive reading of research, was used to accomplish this purpose.
Insulin-like growth factor II overexpression in myoblasts induces phenotypic changes typical of the malignant phenotype

The objective of this study was to examine the role of insulin-like growth factor II (IGF-II) in the pathogenesis of human rhabdomyosarcomas (RMS). We have demonstrated previously that RMS express high levels of IGF-II mRNA, secrete IGF-II peptide, and express both IGF-I and IGF-II receptors. Moreover, we showed that IGF-II functions as an autocrine growth and motility factor in RMS. Since IGF-II is expressed at high levels in fetal muscle cells and RMS are tumors thought to derive from skeletal myoblasts arrested along the normal myogenic pathway, autocrine production of IGF-II by RMS may be an etiological event in the development of this tumor. We have developed a model system which enabled us to study the effects of endogenous IGF-II overprotection in muscle myoblasts. Human cDNA for pre-prohormone IGF-II was transfected into mouse myoblasts in order to achieve high, constant expression of this growth factor, which is normally down-regulated at the end of the differentiation process. Expression of high IGF-II levels resulted in: (a) an increased proliferative rate; (b) impairment of the ability to differentiate into myoblasts; and (c) acquisition of the capability of anchorage-independent growth. No changes in the expression of IGF-I receptors were noted. We conclude that IGF-II overexpression in muscle myoblasts induces morphological and biological changes typical of the malignant phenotype and represents a fundamental event in the pathogenesis of RMS and possibly of other embryonal tumors.
Women's Sex Role Attitudes and Life Satisfaction

Abstract Feminist writers of the 1960s and 1970s argued that women were suffering emotional and psychological stress by adhering to traditionally feminine sex roles, and encouraged women to seek their own careers and change their views of women's roles in society. The purpose here is to test that argument by analyzing samples of women interviewed in national surveys between 1972 and 1978. The author concludes that the feminist writers were overstating the problems of the housewife, and that although many women have gone into new career fields, many other women with traditional sex-role attitudes are happy with their lives.
Cyclosporin A protects lung function from hyperoxic damage.

Cyclosporin A (CsA), an inhibitor of protein phosphatase 2B (calcineurin), has been shown to play a role in exocytosis and neutrophil mobility. Hyperoxia (>95% oxygen for 72 h) causes lung injury a...
Signaling by eNOS through a superoxide-dependent p42/44 mitogen-activated protein kinase pathway.

Expression of endothelial nitric oxide synthase (eNOS) in transfected U-937 cells upregulates phorbol 12-myristate 13-acetate (PMA)-induced tumor necrosis factor-α (TNF-α) production through a supe...
Determination of Dimethoxymethane in Water by Purge-and-Trap Gas Chromatography/Mass Spectrometry

[Objective] To establish a method for the determination of dimethoxymethane in water by purge-and-trap gas chromatography/mass spectrometry(GC/MS).[Methods] The dimethoxymethane in water were purged and trapped,then desorbed and analyzed by gas chromatography/mass spectrometry.The external standard method applied characteristic ions for quantification.[Results] The linearity of the method was good under the experimental condition of dimethoxymethane(r=0.999 5).The detection limit was 0.03 μg/L.The recovery rates were 95.2%-99.3%,and the relative standard deviations(RSD) were 2.18%-3.87%.[Conclusion] The purge-and-trap gas chromatography/mass spectrometry is a sensitive and accurate method for determination of dimethoxymethane in water.
Application of BrdU ELISA in the Detection of Chemical Skin Sensitization

[Objective] To detect the chemical skin sensitization with BrdU ELISA.[Methods]The chemicals,namely DNCB,TCE,TAC,antibiosis colloid were laid on the dorsum of the bilateral mice ears(25μl/ear) for three consecutive days;then the mice received an intraperitoneal injection of BrdU(0.3 ml/mouse) on the fourth day;on the fifth day,the lymph nodes of the mice were removed and weighted,then made into cell suspension,the lymph cell proliferation was measured with BrdU ELISA method;meanwhile the skin sensitization of DNCB,TCE,TAC and antibiosis colloid were tested using the guinea pig Buehler test.[Results]Significant difference was found in the BrdU marker index between the DNCB and TCE groups of different concentration and the AOO solution control group(P0.01);significant difference was also found in the lymph nodes weight between the DNCB groups of different concentrations and the AOO solution control group(P0.01),but not between the TCE groups of different concentrations and the AOO solution control group(P0.05);no significant difference was found in the BrdU marker index of the antibiosis colloid group and the 1% and 5% TAC groups,but significant difference was found in the 10% TAC group(P0.05).[Conclusion] BrdU ELISA has the ability to detect the chemical skin sensitization,but the sensitivity is no better than the guinea pig Buehler test and the Standard Loca1 Lymph Node Assay.
Direct Repair of Iatrogenic Internal Carotid Artery Injury During Endoscopic Endonasal Approach Surgery With Temporary Endovascular Balloon-Assisted Occlusion: Technical Case Report.

Background and importance Iatrogenic internal carotid artery (ICA) injuries during endoscopic endonasal approach (EEA) surgeries are associated with a high morbidity and mortality, with few acceptable methods described for repair. Clinical presentation A 13-year-old girl with a large anterior and central skull base osteoblastoma incurred an iatrogenic cavernous ICA injury during a staged EEA approach. Intraoperative angiogram was performed with balloon-assisted EEA primary microsurgical repair of the lacerated ICA. Conclusion By integrating current techniques commonly used in open aneurysm surgeries and in endovascular procedures, we developed a rapid, safe technique to repair an EEA-associated iatrogenic ICA injury.
Exploring the reaction mechanism in self-propagating Al/Ni multilayers by adding inert material

Abstract We present a new class of reactive materials termed “inert-mediated reactive multilayers” (IMRMs) that use inert material to decouple the effects of chemistry and maximum temperature in a reactive multilayer. Important considerations in the selection of composition and thickness for reactive and inert material in an IMRM are detailed. We then present the results from a specific set of IMRM samples that we fabricated using 23-nm-bilayer 1:1 Al:Ni reactive sections and 2:3 Cu:Ni inert sections. In these samples we observe a systematic reduction of heats of reaction, maximum reaction temperatures, and reaction propagation velocities as the volume fraction of reactive material is reduced. At the same time, metrics sensitive to the reaction mechanism and products indicate that there is little if any cross-contamination between inert and reactive material in any of the samples. This indicates that the IMRM samples all undergo the same net reaction (Al/Ni → AlNi) but at a range of different flame temperatures (roughly 1950 K to 1300 K). Using existing theoretical models for the relationship between flame temperature and propagation velocity, we analyze the experimental data to obtain the activation energy for the mixing process and find that this value varies significantly as the maximum reaction temperature changes. At high reaction temperatures we observe a very low activation energy (26 kJ/mol) which suggests diffusion of Ni in molten Al is the rate controlling mixing mechanism in agreement with the conclusions of other studies focused on un-mediated Al/Ni reactive multilayers. However, as the reaction temperature decreases the activation energy appears to shift to much larger values implying a change in the reaction mechanism. We postulate that this shift indicates that solid products are able to form earlier in the reaction at these temperatures, impeding atomic diffusion and intermixing.
Monotonie optimization for power control of D2D underlay with partial CSI

This paper studies power allocation optimization for D2D-underlay enabled cellular systems where only channel fading information is known at the eNB. Unlike instantaneous channel state information (CSI) assumed in many existing works, statistical (partial) CSI is more readily available from long term practical measurement. Within the partial CSI framework, we study the problem of maximizing ergodic weighted D2D sum rate under cellular outage constraints. While the ergodic sum rate maximization problem is NP-hard for interference channels, the outage constraints make the problem even more challenging. We propose a solution based on the framework of monotonic optimization (MO) by identifying the monotonicity in both rate and outage functions. We apply the branch-reduce-and-bound (BRB) algorithm to solve the MO problem and improve its numerical efficiency. We present simulation results to show the feasibility of proposed solution under various channel models.
Repetition enhancement of amygdala and visual cortex functional connectivity reflects nonconscious memory for negative visual stimuli

Most studies using a recognition memory paradigm examine the neural processes that support the ability to consciously recognize past events. However, there can also be nonconscious influences from the prior study episode that reflect repetition suppression effects-a reduction in the magnitude of activity for repeated presentations of stimuli-that are revealed by comparing neural activity associated with forgotten items to correctly rejected novel items. The present fMRI study examined the effect of emotional valence positive vs. negative on repetition suppression effects. Using a standard recognition memory task, 24 participants viewed line drawings of previously studied negative, positive, and neutral photos intermixed with novel line drawings. For each item, participants made an old-new recognition judgment and a sure-unsure confidence rating. Collapsed across valence, repetition suppression effects were found in ventral occipital-temporal cortex and frontal regions. Activity levels in the majority of these regions were not modulated by valence. However, repetition enhancement of the amygdala and ventral occipital-temporal cortex functional connectivity reflected nonconscious memory for negative items. In this study, valence had little effect on activation patterns but had a larger effect on functional connectivity patterns that were markers of nonconscious memory. Beyond memory and emotion, these findings are relevant to other cognitive and social neuroscientists that utilize fMRI repetition effects to investigate perception, attention, social cognition, and other forms of learning and memory.
Modeling of the interaction of a volumetric metallic metamaterial structure with a relativistic electron beam

We present the design of avolumetric metamaterial (MTM) structure and its interaction with a relativistic electron beam. This novel structure has promising applications in particle beam diagnostics, acceleration, and microwave generation. The volumetric MTM has a cubic unit cell allowing structures of arbitrary size to be configured as an array of identical cells. This structure allows the exploration of the properties of a metamaterial structure without having to consider substrates or other supporting elements. The dispersion characteristics of the unit cell are obtained using eigenmode simulations in the HFSS code and also using an effective medium theory with spatial dispersion. Good agreement is obtained between these two approaches. The lowest-order mode of the MTM structure is found to have a negative group velocity in all directions of propagation. The frequency spectrum of the radiation from a relativistic electron beam passing through the MTM structure is calculated analytically and also calculated with the CST code, with very good agreement. The radiation pattern from the relativistic electron beam is found to be backward Cherenkov radiation, which is a promising tool for particle diagnostics. Calculations are also presented for the application of a MTM-based wakefield accelerator as a possible all-metal replacement for the conventional dielectric wakefield structure. The proposed structure may also be useful for MTM-based vacuum electron devices for microwave generation and amplification.
Abstract P15: Psychometric Properties of the Kansas City Cardiomyopathy Questionnaire

Background: To explore the structure of the Kansas City Cardiomyothy Questionnaire (KCCQ) and compare it to the published version. The KCCQ is a well-established 5 domain, 23-item instrument evalua...
Garp as a therapeutic target for modulation of T regulatory cell function.

ABSTRACTIntroduction: Foxp3+ T regulatory cells (Tregs) play critical roles in immune homeostasis primarily by suppressing many aspects of the immune response. Tregs uniquely express GARP on their cell surface and GARP functions as a delivery system for latent TGF-β. As Treg-derived TGF-β may mediate the suppressive functions of Tregs, GARP may represent a target to inhibit Treg suppression in cancer or augment suppression in autoimmunity.Areas covered: This article will focus on 1) the role of Treg-derived TGF-β in the suppressive activity of Treg, 2) the cellular and molecular regulation of expression of GARP on mouse and human Tregs, 3) the role of integrins in the activation of latent-TGF-β/GARP complex, 4) an overview of our present understanding of the function of the latent-TGF-β/GARP complex.Expert opinion: Two approaches are outlined for targeting the L-TGF-β1/GARP complex for therapeutic purposes. Tregs play a major role in suppressive effector T cell responses to tumors and TGF-β1 may be a majo...
Methods for producing high-purity calcium

The techniques used in the United States for producing calcium metal are described. The methods and attempts to produce high-purity calcium from the crude calcium prepared by the current processes are discussed. A vaporization technique for the distillation of crude calcium is described in detail, and a fractional distillation technique for preparing special high-purity calcium is reported.
Longitudinal Analysis of Quality of Diabetes Care and Relational Climate in Primary Care.

OBJECTIVE To assess the influence of relational climate on quality of diabetes care. DATA SOURCES/STUDY SETTING The study was conducted at the Department of Veterans Affairs (VA). The VA All Employee Survey (AES) was used to measure relational climate. Patient and facility characteristics were gathered from VA administrative datasets. STUDY DESIGN Multilevel panel data (2008-2012) with patients nested into clinics. DATA COLLECTION/EXTRACTION METHODS Diabetic patients were identified using ICD-9 codes and assigned to the clinic with the highest frequency of primary care visits. Multiple quality indicators were used, including an all-or-none process measure capturing guideline compliance, the actual number of tests and procedures, and three intermediate continuous outcomes (cholesterol, glycated hemoglobin, and blood pressure). PRINCIPAL FINDINGS The study sample included 327,805 patients, 212 primary care clinics, and 101 parent facilities in 2010. Across all study years, there were 1,568,180 observations. Clinics with the highest relational climate were 25 percent more likely to provide guideline-compliant care than those with the lowest relational climate (OR for a 1-unit increase: 1.02, p-value <.001). Among insulin-dependent diabetic veterans, this effect was twice as large. Contrary to that expected, relational climate did not influence intermediate outcomes. CONCLUSIONS Relational climate is positively associated with tests and procedures provision, but not with intermediate outcomes of diabetes care.
The Role of Authoritative Parenting in Adolescent Type 1 Diabetes Management.

Objective Adolescents with Type 1 diabetes are at risk for poorer adherence, lower quality of life (QOL), and poorer glycemic control (HbA1c). Authoritative parenting (AP) along with youth adherence and QOL was hypothesized to relate to better HbA1c. Methods Parent-youth dyads (N = 257) completed baseline measures of adherence and QOL. Youth completed an AP questionnaire, and HbA1c samples were evaluated. Structural equation modeling determined relations among AP, adherence, QOL, and glycemic control. Results AP indirectly linked to better HbA1c (β = -.15, p = .021) through both better adherence and higher QOL. AP also was associated directly with better adherence (β = .26, p = .001), which in turn was linked to better HbA1c (β = -.35, p = .021). In addition, adherence was associated directly with QOL (β = -.56, p = .001). Conclusions Together, better youth adherence and higher QOL are two mechanisms by which more AP indirectly relates to better glycemic control during the early adolescent years.
Complete Genome Sequence of Campylobacter jejuni RM1246-ERRC, Which Exhibits Resistance to Quaternary Ammonium Compounds.

ABSTRACT Campylobacter jejuni strain RM1246-ERRC is a clinical isolate. In laboratory experiments, RM1246-ERRC exhibited greater resistance to the antimicrobial effects of quaternary ammonium compounds than other C. jejuni strains. The chromosome of RM1246-ERRC is 1,659,694 bp with a G+C content of 30.56%. The strain also possesses a 45,197-bp plasmid.
Integrated Systems for Managing Bemisia tabaci in Protected and Open Field Agriculture

The combined efforts of disparate entities have produced notable advances in management of Bemisia tabaci (Gennadius) over the decades. On the one hand, entomologists and academicians have focused on specific problems, approaches and solutions, and designed experiments with replicated treatments to provide statistically valid results that hold up to scientific scrutiny. On the other hand, growers must integrate information from all disciplines into a profitable cropping and marketing system in order to survive. The gap between these extremes is often filled by crop consultants or agrochemical sales representatives who may have limited interests, focus or experience. There is clearly a need for more and better information on how management practices can be integrated to provide the desired level of pest suppression while still maintaining a balanced and profitable cropping system. The key challenge to implementing new practices will be to sustain or improve current levels of productivity while minimizing impact on the environment and biodiversity.
Abstract 19036: Three Dimensional Non-Invasive Imaging of Reentrant Vt in Swine With Myocardial Infarction

Introduction: Reentrant Ventricular Tachycardia (VT) represents a significant clinical challenge for its dynamic nature and hemodynamic instability. Three-dimensional (3D) noninvasive electrical imaging has been shown to successfully image various ventricular arrhythmias arising by a focal mechanism. In this study, we report the first 3D validation of Cardiac Electrical Sparse Imaging (CESI) technique on reentrant VT in swine with myocardial infarction. Methods: Body surface potential maps (BSPMs) were recorded using up to 128 electrodes in 3 swine with myocardial infarction induced by the occlusion of the left anterior descending coronary artery. Both structural and delay enhancement MRI scans were performed in each animal. Activation sequences were imaged over 30 randomly selected reentry cycles observed simultaneously with 3D intra-cardiac mapping to quantitatively evaluate the performance of the noninvasive imaging. Results: Good concordance was found between the imaged results and the intra-cardiac recordings. Correlation Coefficient was observed to be 0.79±0.06 and Relative Error 0.22±0.06 between the imaged and intra-cardiac measured activation sequences. The imaged reentry pathways and the slow conduction areas identified were in good agreement with the invasive mapping results and delay enhancement MRI results. The total activation time imaged was on average 218±37ms over the 30 beats compared to the measured 227±21ms. The averaged localization error between the imaged and mapped exit of reentry isthmus was 8.1±1.5mm. Conclusion: We demonstrate the feasibility, for the first time, that the beat-to-beat 3D activation imaging is capable of imaging and visualizing the cardiac electrical activation during reentrant VT with good accuracy. Noninvasive imaging of reentrant VT holds promise for mechanistic insights into reentrant VT and for improvement in ablation approaches for patients with reentrant VT following myocardial infarction.
Supervision in Community Mental Health: Understanding Intensity of EBT Focus

Abstract The goal of the present study was to examine clinician, supervisor, and organizational factors that are associated with the intensity of evidence-based treatment (EBT) focus in workplace-based clinical supervision of a specific EBT, Trauma-Focused Cognitive Behavioral Therapy (TF-CBT). Supervisors (n = 56) and clinicians (n = 207) from mental health organizations across Washington State completed online self-report questionnaires. Multilevel modeling (MLM) analyses were used to examine the relative influence of nested clinician and supervisor factors on the intensity of EBT focus in supervision. We found that 33% of the variance in clinician report of EBT supervision intensity clustered at the supervisor level and implementation climate was the only significant factor associated with EBT supervision intensity. While individual clinician and supervisor factors may play a role in EBT coverage in supervision, our results suggest that an implementation climate that supports EBT may be the most critical factor for improving intensity of EBT coverage. Thus, implementation efforts that address the extent to which EBTs are expected, rewarded, and supported within an organization may be needed to support greater coverage of EBT during workplace-based supervision.
Integrative Aspects of Basal Ganglia Circuitry

The basal ganglia is a set of interconnected subcortical structures that influence cortical activity through corticobasal ganglia loops. Information is thought to flow from the cortex via the striatum to the pallidum and substantia nigra, from the pallidum and the substantia nigra to the thalamus, and finally back to the cortex. Based on some of the pathways and physiology of the basal ganglia sensorimotor circuit in the primate, several theories concerning the organization of the primate basal ganglia have been suggested. A current one proposes that the frontal cortex and the basal ganglia are arranged in parallel, functionally segregated circuits (Alexander et al., 1990). In this concept, each individual circuit has a specific, functionally distinct region of the frontal cortex as a nodal point, and projects to anatomically distinct sectors of the striatum, the pallidum, the substantia nigra, and the thalamus. From there, the thalamocortical pathway completes the loop to cortex. In addition to the sensorimotor circuit, others have been proposed that involve distinct regions of the basal ganglia associated with particular cortical regions including the dorsolateral prefrontal cortex, the orbitofrontal cortex, and the cingulate cortex.
Network imaging biomarkers: insights and clinical applications in Parkinson's disease

Summary Parkinson's disease presents several practical challenges: it can be difficult to distinguish from atypical parkinsonian syndromes, clinical ratings can be insensitive as markers of disease progression, and its non-motor manifestations are not readily assessed in animal models. These challenges, along with others, are beginning to be addressed by innovative imaging methods to characterise Parkinson's disease-specific functional networks across the whole brain and measure their expression in each patient. These signatures can help improve differential diagnosis, guide selection of patients for clinical trials, and quantify treatment responses and placebo effects in individual patients. The primary Parkinson's disease-related metabolic pattern has been replicated in multiple patient populations and used as an outcome measure in clinical trials. It can also be used as a predictor of near-term phenoconversion in prodromal syndromes, such as rapid eye movement sleep behaviour disorder. Functional network imaging holds great promise for future clinical use in the management of neurodegenerative disorders.
Pulp-dentin biology in restorative dentistry. Part 7: The exposed pulp

Exposure of the dental pulp, through a caries lesion, accidentally during routine cavity preparation, or as a result of tooth fracture, is a clinical reality that requires optimal treatment. The potential for healing by formation of a dentinal bridge is good, provided that the pulp is not inflamed. Calcium hydroxide has a long history of inducing dentinal bridge formation to promote successful healing. Resin composites are emerging as alternative materials for pulp capping, but healing is slower, and relatively little clinical experience is available for analysis. The prognosis for healing is poor after exposure of an inflamed pulp. Pulpotomy should be considered to create a wound in an uninflamed location. If an exposure is expected through a caries lesion, stepwise excavation of the carious dentin should be considered to allow healing of the dentin and pulp prior to the final excavation of the carious dentin.
Optimizing the Design of Multilayer Eddy Current Probes — A Theoretical and Experimental Study

General Electric developed a new eddy current probe technology in the early ‘90’s to address critical NDE needs in the aerospace industry. The technology utilizes lasers to trace out precise, multiple turn coils on a flexible substrate. The result is an eddy current probe that is capable of conforming to complex geometries and inspecting with a very high detection sensitivity. To cover large areas quickly, arrays of these coils were also fabricated and are currently in use with great success at GE inspection facilities. The newly developed probes, however, raised some unique questions and problems that needed to be addressed in order to determine the“best” probe configuration. In this paper we summarize these issues and through a combination of experimental and finite element results, we show how the design of the probe is“optimized” for various applications. Further details on the development of the technology are provided in a companion paper in these proceedings[1].
ZIRCONIUM REAGENTS IN ORGANIC SYNTHESIS

Abstract Carbon-carbon bond-forming procedures are described which involve organozirconium complexes in tandem with other metallic species. Mechanistic considerations for these reactions are described.
Cyber anomaly detection: Using tabulated vectors and embedded analytics for efficient data mining:

Firewalls, especially at large organizations, process high velocity internet traffic and flag suspicious events and activities. Flagged events can be benign, such as misconfigured routers, or malig...
Pre-injection wheel running preserves mobility in a rodent model of paclitaxel neurotoxicity.

e21640Background: Peripheral neurotoxicity (PN), a common side-effect of paclitaxel (Ptx) chemotherapy, can reduce quality of life through persistent balance/gait dysfunction, and even shorten surv...
Vitamin D binding protein: a new biomarker of disease severity in lymphangioleiomyomatosis

Vitamin D binding protein is a novel biomarker of disease severity in LAMhttp://ow.ly/qGdc30ml0EE
Screening of Hyperlipidemia Among Patients With Rheumatoid Arthritis in the United States.

Objective To determine the proportion of primary lipid screening among patients with rheumatoid arthritis (RA) and compare it with those among patients with diabetes mellitus (DM) and patients with neither RA nor DM, and to assess whether primary lipid screening varied according to the health care provider (rheumatologist versus non-rheumatologist). Methods We analyzed claims data from US private and public health plans from 2006-2010. Eligibility requirements included continuous medical and pharmacy coverage for ≥12 months (baseline period) and >2 physician diagnoses and relevant medications to define RA, DM, RA and DM, or neither condition. Among the 330,695 eligible participants, we calculated the proportion with a lipid profile ordered during the 2 years following baseline. Time-varying Cox proportional hazard models were used to determine the probability of hyperlipidemia screening in participants with RA according to provider specialty. Results More than half of the patients were ages 41-71 years. Among patients with RA (n = 12,182), DM (n = 62,834), RA and DM (n = 1,082), and those who did not have either condition (n = 167,811), the proportion screened for hyperlipidemia was 37%, 60%, 55%, and 41%, respectively. Patients with RA who visited a rheumatologist and a non-rheumatology clinician during follow-up had a 55% (95% confidence interval 1.36-1.78) higher screening probability than those who only visited a rheumatologist. Conclusion Primary lipid screening was suboptimal among patients with RA. It was also lower for patients with DM and minimally different from the general population. Screening was higher for RA patients who received care from both a rheumatologist and a non-rheumatologist (e.g., primary care physician).
The effects of urbanization and land use on ragweed distribution

Quantifying the spatial distribution of allergenic plants within landscapes could help target management efforts and predict human exposure to allergens at a scale relevant to human activity. We analyzed the combined effects of urbanization (proxied by surrounding impervious surface area) and land use on the distribution of common ragweed (Ambrosia artemisiifolia, Asteraceae), a major contributor to hay fever and asthma through its production of allergenic pollen. Along urban‐to‐rural transects in three regions of the northeastern United States, we recorded the presence of ragweed in 308 plots with different land uses: agriculture, developed, and forest. We also analyzed the effects of plot‐level soil moisture, soil carbon‐to‐nitrogen ratio, and canopy cover on ragweed occurrence. Ragweed varied among land uses, but the effect of land use depended on the level of urbanization. The probability of ragweed occurrence was highest in urban forests, rural developed areas, and agricultural areas. Plot‐level abiotic variables were not related to ragweed occurrence. Our results suggest that ragweed distributions are influenced to a greater extent by landscape‐scale processes, such as propagule pressure and disturbance, than by macro‐environmental effects of urbanization. From a human health perspective, our results suggest that ragweed pollen levels vary within and between urban and non‐urban landscapes, which current pollen monitoring and forecasting efforts do not capture.
Mutagen sensitivity of Drosophila melanogaster. III. X-linked loci governing sensitivity to methyl methanesulfonate.

Twenty-eight X-linked, recessive mutations of Drosophila melanogaster conferring enhanced sensitivity to the monofunctional alkylating agent, methyl methanesulfonate, have been recovered and assigned to five complementation groups. These groups can be distinguished on the basis of map location and variations in the pattern of mutagen sensitivity. Allelism of members of one complementation group with the previously described meiotic mutant, mei-41, (Baker and Carpenter, 1972) as well as the frequent appearance of female infertility with mutagen sensitivity suggests associated defects in meiotic chromosome behavior or early embryogenesis. Examination of the mutagen sensitivity of double mutants has led to the formulation of a working model of DNA repair for this organism. Studies of a similar nature (Boyd et al., 1976) have identified five additional X chromosome complementation groups, suggesting that the genome of Drosophila melanogaster may contain many loci involved with mutagen sensitivity. The continued isolation and characterization of conditional mutants of this type promises future insights into the mechanisms of DNA replication, DNA repair and recombination in this complex higher eucaryote.
Self-silencing in school: failures in student autonomy and teacher-student relatedness

Self-silencing (Jack in Silencing the self: women and depression, Harvard University Press, Cambridge, 1991; Jack and Ali, in: Jack, Ali (eds) Silencing the self across cultures: depression and gender in the social world, Oxford University Press, New York, 2010), the tendency to silence one’s self-expressions in service of maintaining important relationships, has been studied primarily as a risk factor for depression in women. In this study, self-silencing in teacher-student relationships was assessed in a sample of college students (n = 142) and 4th-graders (n = 52), using a new scale adapted from Jack and Dill’s (Psychol Women Q 16:97–106, 1992) Silencing the Self scale. Self-silencing in school was shown to be related to several negative academic outcomes in both samples, including low behavioral engagement, negative emotions (i.e., sadness, anxiety, anger), and maladaptive strategies for coping with failure. The results of path analyses suggested that self-silencing relates to poor academic outcomes through its association with reduced student autonomy and poor teacher-student relationship quality. Based on these results, a reinterpretation of self-silencing through the perspective of self-determination theory (Ryan and Deci in Self-determination theory: basic psychological needs in motivation, development, and wellness. The Guilford Press, New York, 2017) is presented.
Characterization of the ETEL D784UKFLB 11 in. photomultiplier tube

Abstract Water Cherenkov and scintillator detectors are a critical tool for neutrino physics. Their large size, low threshold, and low operational cost make them excellent detectors for long baseline neutrino oscillations, proton decay, supernova and solar neutrinos, double beta decay, and ultra-high energy astrophysical neutrinos. Proposals for a new generation of large detectors rely on the availability of large format, fast, cost-effective photomultiplier tubes. The Electron Tubes Enterprises, Ltd (ETEL) D784KFLB 11 in. Photomultiplier Tube has been developed for large neutrino detectors. We have measured the timing characteristics, relative efficiency, and magnetic field sensitivity of the first fifteen prototypes.
The 4Rs in radiation therapy

It has been realized that the 4Rs (repair, repopulation, redistribution, and reoxygenation) would affect the result of cell irradiation, and thus radiation treatment. The 4Rs each occurs at different dose rates, usually very low dose rates. Depending on the dose rate used for treatment, the corresponding R should be included in the linear－quadratic equation (LQ) and biological effective dose (BED) calculation. For low dose rate brachytherapy(LDR) especially permanent implant, all the 4Rs should be included in LQ for BED calculation. The 4Rs, especially repair and repopulation, play a critical role in dose fractionation. Various dose fractionation schemes such as hyperfractionation and hypofractionation are determined in consideration of the 4Rs. Stereotactic radiation therapy uses hypofractionation with high fractional doses and combine with high accuracy target localization techniques to achieve high local control rates compared to conventional dose fractionation schemes. The 4Rs have been taken into account for LDR and permanent implant. Recently, LQ for permanent implant brachytherapy has been modified to include all the 4Rs for gynecological malignancy 131Cs permanent implants. Including the 4Rs in radiation therapy has significantly improved the effectiveness and efficiency of radiation therapy for cancer treatment. Key words: Repair; Repopulation; Redistribution; Reoxygenation; Linear quadratic equation
RFID in Today’s Intelligent Hospital Enhancing Patient Care & Optimizing Hospital Operations

Over the last decade the changing healthcare environment has driven hospitals to critically evaluate and optimize their operations to enhance patient treatment and care, while focusing on financial constraints. The hospitals have moved to support an increasing outpatient care environment, driving increasing in-patient acuity levels. At many institutions these changes have been accompanied with regulatory and financial constraints impacting the operating budgets. Specific initiatives, such as the Joint Commission’s patient safety goals, electronic medical record and meaning full use have driven institutions to re-design their operations and processes, using technology solutions to achieve these goals, while optimizing operational workflow and resource utilization. To deal with the complexity of patient care workflows, enhance patient diagnosis, treatment, care, safety and satisfaction, the design of Intelligent Hospitals has focused on the integration of diverse technologies, to provide a seamless exchange of information. This has driven hospitals to integrate RFID into a variety of hospital operations and processes. The overall cost of an RFID deployment not only includes the capital purchase but more significantly the on-going operational cost and impact. RFID systems represent a significant investment were the return on investment is realized through the deployment of a broad set of applications and use cases. RFID includes two main types of solutions, including institutional visualization and tracking and localized choke point solution including validations and process verification. This paper outlines the strategies for the deployment of large scale RTLS / RFID solutions based on 10+ years of experience at Memorial Sloan Kettering Cancer Center (MSK). MSK has deployed 12,000 active tags and 35,000 passive tags associated to medical devices. The strategies include, system scaling, requirements for accuracy and resolution, program management, managing an increasing quantity of tags and tag types, monitoring the effectiveness of the solution and managing impacts of complexity and interference, as well as establishing dedicated support model and structure. The paper highlights multiple uses targeting enhanced asset management, optimized workflow and process validation.
High-performance Hardware Architecture for Tensor Singular Value Decomposition: Invited Paper

Tensor provides a brief and natural representation for large-scale multidimensional data by way of appropriate low-rank approximations, thus we can discover significant latent structures of complex data and generalize data representation. To date, tensor has gained tremendous success in various science and technology fields, especially in machine learning and big data applications. However, tensor computation, especially tensor decomposition, is usually expensive due to the inherent large-size characteristic of tensors, and hence would potentially hinder their future wide deployment. In this paper, we develop a hardware architecture to accelerate tensor singular value decomposition (t-SVD), which is a new tensor decomposition technique that has been successfully applied to high-dimensional data classification and video recovery. Specifically, design consideration of each key computing unit is analyzed and discussed. Then, the proposed t-SVD hardware architecture is implemented and synthesized using CMOS 28nm technology. Comparison with real-world CPU-based implementations shows that the proposed hardware accelerator is expected to provide average 14× speedup on various t-SVD workloads.
State variation in the drug felony lifetime ban on Temporary Assistance for Needy Families: Why the modified ban matters:

The drug felony lifetime ban on Temporary Assistance for Needy Families (TANF) affects thousands of individuals with felony drug convictions in the United States. Federal law allows states to choos...
Quark and Gluon Helicity at Small $x$

We determine the small-x asymptotics of the quark and gluon helicity distributions in a proton at leading order in perturbative QCD at large Nc. To achieve this, we first evaluate the quark and gluon helicity TMDs at small x, simplifying them and relating them to the so-called polarized dipole amplitudes. We then construct and solve novel small-x large-Nc evolution equations for the polarized dipole amplitudes. Our main results are the small-x asymptotics for the quark helicity distributionΔq ∼ (1x)αhq with αhq = 43αs Nc2π ≈2.31 αs Nc2π (1)and the small-x asymptotics of the gluon helicity distributionΔG ∼ (1x)αhG with αhG = 1343αs Nc2π ≈ 1.88αsNc2π, (2)both in the large-Nc limit.
A Model-Based Approach for Correcting State of Charge Drift in Hybrid Electric Vehicles

Battery state of charge (SOC) is among the most important measures made by an hybrid electric vehicle battery management system since accurate SOC estimation can improve efficiency of power distribution, which can increase fuel economy, extend battery useful life, and ensure balanced pack operation. Existing methods that rely mostly on current integration are prone to sensor bias, causing the resulting estimate to drift away from the true value. This work describes an adaptive model-based method using an equivalent-circuit model augmented with a bias state that is able to correct SOC drift while driving and reduce SOC reset based on open-circuit voltage at key-on.
Alternative Maps for Navigating the First Amendment Maze - A Review of 'THE FIRST AMENDMENT'

In this review, I am going to focus on two sections of his book where Farber's analysis and selectivity in including argu­ments creates too much dissonance with the way that I under­stand the cases and issues for his work to be useful to me in teaching my classes. Instead of noting various disagreements that I may have with his analysis, as book reviewers typically do, however, I thought it might be more useful to provide compara­tive frameworks to help illustrate the differences between Far­ber's approach and my own. Accordingly, after summarizing the way Farber discusses the issues in these sections, I will describe the way I would present the same material. That comparison, hopefully, will demonstrate why it might be difficult for students to shift from one perspective to the other. Then, after juxtapos­ing alternative discussions of two free speech areas at some length, I will briefly sketch similar problems in a few other sec­tions of Farber's work. Of course, other readers might have less of a problem with the areas of The First Amendment that bother me, but would identify different sections of this work, sections that I found to be thorough and persuasive, as incomplete or off center from their perspective. The point isn't that any of these competing understandings of free speech cases and principles is necessarily more accurate and convincing than Farber's analysis. Rather, it is that under the current state of free speech case law we do not have an adequate, agreed-upon foundation on which we can stand and evaluate alternative doctrinal interpretations. Be­cause of the seemingly systemic indeterminacy in so many free speech cases, we are left in a doctrinal world in which I seriously dispute very little of what Farber writes in this book, but I some­times see things very differently or emphasize very different as­pects of an issue in my classes.
Bullying Victimization among Children with Food Allergies and Parental Mental Health

Children with food allergies are bullied at higher rates than the general population. Little research, however, has considered how parents of children with food allergies may be affected by the bul...
Are memories of sexual trauma fragmented

Alarmingly high rates of sexual assault on campus have motivated American colleges and universities to take steps to address this serious problem. Yet university administrators have often felt ill-...
The Dependency of Rent-to-Price Ratio on Appreciation Expectations: An Empirical Approach

Using two unique datasets from different neighborhoods in Houston, TX, which provide us data for houses with similar structure (or even same house), we test the standard model of housing values to determine how the formation of households' expectations regarding price appreciations affects housing market prices. Using these datasets we are able to address previously encountered problems in the literature such as the lack of adjustment for quality differences, the connection between prices and rents for the different type of housing, and the spatial distribution of housing. We test whether consumer behavior leads to potentially unstable market conditions with price bubbles. Our results suggest that appreciation expectations are based on past price appreciation but at the same time they depend on the fundamental factors such as, locational and structural. These findings show a hybrid consumer behavior of rational and adaptive expectations. Finally, we show how these expectations could sometimes lead to unstable price levels.