cssi/SciSciGPT-SciSciNet huggingface dataset:
A fuzzy causal measure of individual patient treatment response

We (2002) previously defined a necessary and sufficient causal ground to derive a formal causal ground in the unit hypercube. In addition we derived the clinical causal effect. These measures are developed from the fuzzy subset theorem as defined by Kosko (1992) and are in units of cardinality. In this paper we develop a measure of clinical efficiency K which is expressed in units of cardinality and is derived from the measures of formal causal ground and clinical causal effect. The measure of clinical efficiency was applied to 16 patients on an antiplatelet therapy. It renders a unique measure of clinical therapeutic effect for each patient. The measure of clinical efficiency developed herein can be used as an alternative to probability-based statistics to judge clinical causality.
Accelerator Column Models for Low-Current Beams

This paper describes three analytic approaches used to model electrostatic accelerator columns in beam-transport codes for low-current beams and compares the results of each approach with the results obtained by numerically calculating the electric field based on charge distribution on equipotential surfaces. The three analytic approaches described are (1) a cubic energy-gain approximation, (2) a cubic longitudinal electric-field approximation, and (3) the aperture equation. The first two approaches calculate impulse approximations at the apertures, whereas the third is an integration of particle trajectories through the column field. The conditions under which the solutions tend to break down are discussed.
Cerebral Amyloid Angiopathy: CT and MR Imaging Findings

Cerebral amyloid angiopathy (CAA) is an important but underrecognized cause of cerebrovascular disorders that predominantly affect elderly patients. CAA results from deposition of β-amyloid protein in cortical, subcortical, and leptomeningeal vessels. This deposition is responsible for the wide spectrum of clinical symptoms and neuroimaging findings. Many cases of CAA are asymptomatic. However, when cases are symptomatic, patients can present with transient neurologic events, progressive cognitive decline, or potentially devastating intracranial hemorrhage. Computed tomography is the imaging study of choice for evaluation of suspected acute cortical hemorrhage, which may be accompanied by subarachnoid, subdural, or intraventricular hemorrhage. Magnetic resonance imaging is best suited for identification of small or chronic cortical hemorrhages and ischemic sequelae of this disease, exclusion of other causes of acute cortical-subcortical hemorrhage, and assessment of disease progression. Accurate recogniti...
Transmission of multidrug-resistant tuberculosis in the USA: a cross-sectional study

Summary Background Multidrug-resistant (MDR) tuberculosis is a potential threat to tuberculosis elimination, but the extent of MDR tuberculosis disease in the USA that is attributable to transmission within the country is unknown. We assessed transmission of MDR tuberculosis and potential contributing factors in the USA. Methods In a cross-sectional study, clinical, demographic, epidemiological, and Mycobacterium tuberculosis genotype data were obtained during routine surveillance of all verified cases of MDR tuberculosis reported from eight states in the USA (California from Jan 1, 2007, to Dec 31, 2009; Texas from Jan 1, 2007, to March 31, 2009; and the states of Colorado, Maryland, Massachusetts, New York, Tennessee, and Washington from Jan 1, 2007 to Dec 31, 2008). In-depth interviews and health-record abstraction were done for all who consented to ascertain potential interpersonal connections. Findings 168 cases of MDR tuberculosis were reported in the eight states during our study period. 92 individuals (55%) consented to in-depth interview. 20 (22%) of these individuals developed MDR tuberculosis as a result of transmission in the USA; a source case was identified for eight of them (9%). 20 individuals (22%) had imported active tuberculosis (ie, culture-confirmed disease within 3 months of entry into the USA). 38 (41%) were deemed to have reactivation of disease, of whom 14 (15%) had a known previous episode of tuberculosis outside the USA. Five individuals (5%) had documented treatment of a previous episode in the USA, and so were deemed to have relapsed. For nine cases (10%), insufficient evidence was available to definitively classify reason for presentation. Interpretation About a fifth of cases of MDR tuberculosis in the USA can be linked to transmission within the country. Many individuals acquire MDR tuberculosis before entry into the USA. MDR tuberculosis needs to be diagnosed rapidly to reduce potential infectious periods, and clinicians should consider latent tuberculosis infection treatment—tailored to the results of drug susceptibility testing of the putative source case—for exposed individuals. Funding Centers for Disease Control and Prevention.
Disrupting Wisdom 2.0: The Quest for "Mindfulness" in Silicon Valley and Beyond

In early 2014 activist Amanda Ream and members of Eviction Free San Francisco disrupted the fifth annual Wisdom 2.0 conference, at which Silicon Valley leaders discuss the benefits of ‘mindfulness’ practices. It was another confrontation between working-class residents of San Francisco and the technology employees who have gentrified their neighborhoods. A member of the East Bay Meditation Center in Oakland, Ream’s actions garnered support from other ‘socially engaged’ Buddhists from Berkeley and elsewhere. Secular critics have likewise questioned the appropriation of Buddhist practices by corporations whose business practices and products arguably undermine the cultivation of mindfulness. This article intervenes in these debates by outlining an approach called Contemplative Media Studies, which integrates critical media studies with the emerging field of Contemplative Studies. I argue that market imperatives have favored a corporate-friendly understanding of mindfulness that perpetuates structural injustice, and conclude that an expanded notion of civic mindfulness must include the revitalization of journalism and the development of non-commercial media systems.
Connections: 2015 ICMI Sustained Accomplishment Award Lecture

Our community has long pursued principles and methods for enabling fluid and effortless collaborations between people and computing systems. Forging deep connections between people and machines has come into focus over the last 25 years as a grand challenge at the intersection of artificial intelligence, human-computer interaction, and cognitive psychology. I will review experiences and directions with leveraging advances in perception, learning, and reasoning in pursuit of our shared dreams.
Palliative care: from medicine to surgery, from adults to children, and from calls to action to community approaches to advanced care planning

This issue of Annals of Palliative Medicine marks the inaugural issue of the new and recurring column entitled, “Surgical Palliative Care” (1). This long-overdue column will focus on the role of surgeons in the field of palliative medicine. The scope of the column is beyond that of just palliative surgeries, and it includes novel surgical approaches and outcomes, significant advances in surgical palliative care, and reviews across the surgical disciplines in the field of palliative care. For the premier manuscript of the column, Geoffrey P. Dunn, MD, FACS, Surgical Palliative Care Subcommittee Chair of Annals of Palliative Medicine, authored an informative perspective piece on the evolution of surgery, palliative care, and the American College of Surgeons (2). Dunn details the role that the American College of Surgeons has played in advancing palliative care for patients receiving surgical care, and he accounts the inception of the Committee on Surgical Palliative Care (CSPC).
On the chemical kinetics of n-butanol: ignition and speciation studies.

Direct measurements of intermediates of ignition are challenging experimental objectives, yet such measurements are critical for understanding fuel decomposition and oxidation pathways. This work p...
Bayesian Model Averaging for Reliability Analysis with Probability Distribution Model Form Uncertainty

rst specify probability distribution models for all of the input random variables. In practice, these models are often estimated based on observed data, and doing so introduces uncertainty because the true underlying probability distributions are unknown. Recent work has shown that this uncertainty can be addressed by quantifying the amount of uncertainty present in the estimated distribution model parameters. However, such an approach still assumes that the form of the probability distribution model is known. In this paper, we present an approach that makes use of Bayesian model averaging to quantify uncertainty associated with both distribution model parameters and distribution model form. The proposed approach is demonstrated for the reliability analysis of a bistable MEMS device; we make use of the Ecient Global Reliability Analysis method to eciently propagate the distribution uncertainty through the reliability analysis.
Accumulation of Risk and Promotive Factors Among Young Children in US Military Families.

In the families of the new cohort of war veterans now entering the civilian population in the United States are over two million young children (Cozza, Haskins & Lerner, 2013; Institute of Medicine, 2013). Several noteworthy studies have shown that children exposed to separation from a parent due to combat-related deployment are at elevated risk for a variety of negative consequences (Lester & Flake, 2013). Cozza et al. (2013) argue that existing studies of military children focus too much on the stresses or deficits they experience, failing to give sufficient attention to their strengths, the strengths of their families, or the supports around them. In the current study we focus on risk and promotive factors in the lives of children aged 0–10 in military families. We examine the likelihood of negative outcomes as functions of additive, cumulative, and interactive relationships between risk and promotive factors and children's outcomes. Risk factors, particularly parental depression, community poverty, and cumulative risk, were more strongly associated with children's outcomes than promotive factors. There was, however, a significant risk-protective relationship between accumulations of risk and promotive factors, consistent with promotive conditions operating in a protective fashion under conditions of elevated risk.
Development and evaluation of a silver mordenite composite sorbent for the partitioning of xenon from krypton in gas compositions

ABSTRACTA new engineered form composite sorbent for the selective separation of xenon from krypton in simulant composition off-gas streams resulting from the reprocessing of used nuclear fuel has been developed and evaluated. A sodium mordenite powder was incorporated into a macroporous polymer binder, formed into spherical beads and successfully converted to a 9 wt.% silver form composite sorbent. The final engineered form sorbent retained the characteristic surface area indicative of sodium mordenite powder. The sorbent was evaluated for xenon adsorption potential with capacities measured as high as 30 millimoles of xenon per kilogram of sorbent achieved at ambient temperature and 460 millimoles of xenon per kilogram sorbent at 220 K. Xenon/krypton selectivity was calculated to be 22.4 with a 1020 µL/L xenon, 150 µL/L krypton in a balance of air feed gas at 220 K. Adsorption/desorption thermal cycling effects were evaluated with results indicating sorbent performance was not significantly impacted while...
Development of Thinking for Speaking: What Role Does Language Socialization Play?.

It has been noted that Chinese shows both satellite- and verb-framed properties (Beavers, Levin, & Tham, ; Slobin, ), a fact that offers the opportunity to explore the typological influence of learners' dominant language because they can choose either option to describe the same motion events and be grammatically correct. This study comprehensively examined the impact of factors including the dominant language's thinking for speaking (TFS) (Slobin, , , ), as well as proficiency and degree of socialization with the target language. It examined oral narratives produced by 80 learners of Chinese representing two proficiency levels (low vs. high) and two linguistic backgrounds (heritage language vs. foreign language), as compared to two baseline groups of 40 Chinese native speakers (NSs) and 40 English NSs. Analysis of the motion verbs and motion constructions showed a limited role of the dominant TFS. While the more proficient learners were more capable of producing task-relevant motion expressions regardless of their language background, only advanced heritage learners demonstrated target-like TFS. Comparison of heritage and foreign language learners at the same proficiency level suggests that degree of language socialization plays a crucial role in facilitating development of TFS in the target language. [ABSTRACT FROM AUTHOR]
Cockroach invasion situation and its control measure in Jurong city

Objective In order to understand and grasp species and density of cockroach in urban area of Jurong city,and provide scientific preventive measures for the establishment of the National Health City. Methods Eye seeing,cockroach catching box and insecticide stimulating method. Results Of the 375 investigated rooms,cockroaches belonged to 2 section,2 genera and 3 species.There were 627 imago and namphae.The imago and namphae occupied 43.54% and 56.46% respectively.The postive ratio of cockroach trace was 17.33%,and the invasion ratio was 14.4%.The cockroach density was 0.84 pieces per box for every night. Conclusion In Jurong city,cockroach trace room was 2.5 times more than the standard.Cockroach postive room was 3.8 times more than the standard.In order to pass through the examination of the National Health City,it is necessary to strengthen management,training and take integrated control.
Dyke Award. Imaging of Spinal CSF Pulsation by 2DFT MR: Significance During Clinical Imaging

Understanding the MR appearance of spinal CSF is important in interpreting clinical spine images because the diagnosis of spinal pathology requires an accurate delineation of spinal CSF from spinal cord and thecal sac. During conventional 2DFT MR imaging of the spine, CSF pulsation caused two interdependent flow phenomena, signal loss and phase-shift images. Signal loss was observed as decreased signal intensity arising from pulsatile spinal CSF. Phase-shift images were observed as signal intensity arising from and morphologically identical to the spinal subarachnoid space but symmetrically displaced from it along the phase-encoding axis of MR images, either added to or subtracted from stationary signal intensity. These phenomena were common, occurring in most cervical and thoracic long-TR images. Both phenomena were less apparent in the lumbar region in most cases. CSF pulsation flow phenomena decreased CSF-spinal cord and CSF-thecal sac conspicuity, thereby obscuring normal and pathologic anatomy and, at times, simulating pathology. The areas of signal loss showed variable but characteristic patterns in the cervical and thoracic spine corresponding to regions of greatest flow. Signal loss in the axial plane was more pronounced when thin slices were used. Phase-shift images degraded overall image quality secondary to spatial mismapping of spinal CSF signal intensity. With the use of CSF gating, both signal loss and phase-shift images were eliminated. Understanding these features will be important in the accurate interpretation of MR spine images because analysis of CSF pulsation flow phenomena provides physiologic and pathologic information, and awareness of their existence avoids diagnostic confusion.
The Function to Serve A Social-Justice-Oriented Investigation of Community College Mission Statements

This study investigated the ways that mission statements from 70 Hispanic-serving community colleges communicated their commitment to their Hispanic-serving function. Reference specifically to the Hispanic-serving function was absent, but references to culture and access were relatively common. Findings describe the ways culture and access were used in the mission statements. The article suggests more explicit reference to the Hispanic-serving nature of the institution in materials readily available to the public.
Postmeningeal puncture headache and spontaneous intracranial hypotension

Abstract Meningeal puncture headache (MPH), commonly known as postdural puncture headache (PDPH), is an orthostatic bilateral headache following meningeal puncture. The headache can be associated with other symptoms, like neck stiffness, nausea, vomiting, visual changes, auditory changes, and mental status changes. It usually presents within 24–48 hours after a meningeal puncture and resolves within 7 days but in rare cases may persist for months. The incidence of developing a headache after a meningeal puncture depends on the needle size, the design of the needle tip, and the orientation of the bevel during meningeal puncture. The smallest practical needle diameter with a noncutting tip is associated with the lowest risk of MPH. Independent risk factors of MPH include the female gender, pregnancy, falling in the age group of 20–50 years of age, and having a low body mass index. Treatment of MPH should be balanced by the understanding that 85% of MPHs last less than 5 days and that MPHs are rarely associated with significant morbidity. Thus initial therapy should be conservative relying on hydration and medications. An epidural blood patch (EBP) is the gold standard in treating MPH not responding to conservative management.Spontaneous intracranial hypotension (SIH) is a syndrome with symptoms similar to MPH in a patient with no history of meningeal puncture. Computed tomography myelography (CTM) is the diagnostic procedure of choice to show the location and extent of CSF leak in SIH. EBPs are the treatment of choice. Several EBPs may be required.
Molar and Molecular Contingencies and Effects of Punishment in a Human Self-Control Paradigm

An attempt was made to establish a human self-control paradigm where impulsive response binges produced a greater reinforcement density at the molecular, or short term, level but where self-control responses produced a greater reinforcer density at the molar, or long term, level. Humans earned points by pressing two buttons. Pressing one of the buttons, the impulsive choice, produced 2 points over 1 s. Pressing the other button, the self-controlled choice, produced 10 points over 1 s after a delay of 19 s. In Experiment 1, subjects made 30 choices in a delay condition and 30 choices in the no delay condition. In the delay condition reinforcement of an impulsive response was followed by a 19-s postreinforcer delay that made trial durations equal for both impulsive and self-control choices. In the no delay condition there were no postreinforcer delays following impulsive choices. However, there was a wait period after every 10 trials equal to 19 s times the number of impulsive choices on the previous 10 trials. Thus, in the no delay condition at molecular level, impulsive responding produced a reinforcement density that was greater than the reinforcement density produced by self-controlled responding. However, because of the wait periods, at the molar level self-control responding produced the greatest density of reinforcement. In the delay condition self-controlled responding produced the greatest density of reinforcement at both the molar and molecular levels. Subjects exposed to the no delay condition first responded impulsively during the no delay condition but in a self-controlled fashion during the delay condition. Subjects who received the delay condition first were self-controlled during the delay condition and maintained self-controlled responding during the no delay condition. In Experiment 2 the no delay paradigm was used for 60 trials with punishment and no punishment conditions. In the punishment condition, which occurred either during the first or final 30 trials, following an impulsive response, “NO!” would appear on the screen concurrent with a 0.5-s, 92-db tone. Subjects who experienced the no punishment condition first tended to be impulsive during the no punishment phase but became self-controlled during the punishment condition. Subjects exposed to punishment in the first 30 trials were self-controlled during punishment and maintained self-controlled responding during the no punishment condition. These results suggest that once preference for self-control is developed, self-control responding may be maintained even when impulsive responding produces a greater density of reinforcement at the molecular level.
Transient and dynamic stability enhancement by coordination control of HVDC links of northwest ac\dc grid

In this paper, Transient stability enhancement by emergency power control and damping of slow oscillations with active power modulation of HVDC-links are analyzed. Digital simulations show that emergency power control can improve the transient stability and proper selected of active power controller can effectively suppress the inter-area oscillation in large-scale ac/dc hybrid power grid.
Acouphènes pulsatile et une anomalie des osselets inhabituel

Annales Francaises d'Oto-Rhino-Laryngologie et de pathologie cervico-faciale - Vol. 132 - N° 4 - p. 223-224
A highly parallel implementation of k-means for multithreaded architecture

We present a parallel implementation of the popular k-means clustering algorithm for massively multithreaded computer systems, as well as a parallelized version of the KKZ seed selection algorithm. We demonstrate that as system size increases, sequential seed selection can become a bottleneck. We also present an early attempt at parallelizing k-means that highlights critical performance issues when programming massively multithreaded systems. For our case studies, we used data collected from electric power simulations and run on the Cray XMT.
Cerebrospinal fluid protein carbonylation identifies oxidative damage in autoimmune demyelination

Oxidative damage occurs in multiple sclerosis, but is difficult to identify antemortem and remains an unknown contributor to disease progression. Carbonylation is a quantitative measure of protein oxidation. Cerebrospinal fluid samples from multiple sclerosis patients showed elevated carbonylated protein levels compared to controls. In experimental autoimmune encephalomyelitis, carbonylated protein levels in cerebrospinal fluid correlated tightly with those found in inflamed spinal cord tissues. Furthermore, concentrations in cerebrospinal fluid and spinal cord responded in parallel to an antioxidant intervention that also attenuated disease symptoms. These data suggest that carbonylated cerebrospinal fluid proteins could be a quantitative, sensitive, and disease-relevant biomarker in multiple sclerosis.
The heliconical nematic twist-bend phase from “classic” bent-core benzylideneanilines with oligomethylene cores

ABSTRACTWe report the synthesis and properties of several new heliconical twist-bend nematic (NTB) bimesogens possessing “classic” bent-core benzylideneaniline wings combined with oligomethylene spacers of odd parity. While short alkoxy tails combined with a resorcinol diester core in the classic system appear to give SmA phases (not B2 phases), in the present system, methoxy or ethoxy tails exhibit the NTB phase as evidenced by textural analysis. Several of these compounds also exhibit microscopic helical defect structures in the NTB phase, which have been reported in other lamellar and pseudo-lamellar liquid crystal phases, but not in the NTB phase.
Recommendations on the use and nonuse of the p value in biomedical research.

Much has been written about the abuse of the p value and hypothesis testing in clinical and epidemiologic studies.[1][1]–[7][2] Greenland and colleagues[8][3] noted that “a key problem is that there are no interpretations of these concepts that are at once simple, intuitive, correct, and
Sexual Assault, Sexual Orientation, and Reporting Among College Students

Research has demonstrated significantly higher rates of sexual assault victimization among lesbian, gay, bisexual and queer (LGBQ) students than heterosexual students, and the overwhelming majority of assaults are not reported to any official system. Given the potential for support services to provide valuable assistance and promote well-being after an assault, the present study explores whether LGBQ students report assaults at similar rates to heterosexual students. As part of the 2015 College Student Health Survey, 10,646 male and female college students at 2- and 4-year colleges in Minnesota provided data regarding sexual assault victimization; reporting to a health care provider, campus authority, police, or social contact; and sexual orientation (two items, including write-in). Chi-square tests were used to detect associations between sexual assault victimization and five sexual orientation groups; and between sexual orientation and assault reporting (for 523 assault incidents). Almost 6% of students reported that they had experienced sexual assault in the previous 12 months. Significant differences in assault experience were seen by sexual orientation groups, for both males and females. For example, rates of sexual assault were 2.5 to over 5 times higher among bisexual and queer/pansexual/other females than among heterosexual females. Reporting of sexual assault to health care providers, campus authorities or police was rare for both heterosexual and sexual minority students, and there were no significant differences in reporting across sexual orientation. LGBQ students and heterosexual students appear to be similarly comfortable accessing health care providers, police, and campus resources, suggesting that these services are not overtly biased or unwelcoming to sexual minorities. However, rates of sexual assault were considerably higher among sexual minority groups, suggesting a need for primary prevention that is appropriate and sensitive to the experiences of LGBQ students.
Direct Reduction of Copper Slag Composite Pellets Within Lignite Using Biomass as Binder

The resource utilization of copper slag is an attractive option of iron resource. Thermal energy recovery and direct reduction (TER-DR) system was proposed in this study. By theoretical analysis, the exergy efficiency of this system can reach to 57.3%. To investigate the feasibility of TER-DR system, copper slag composite pellets within lignite were prepared. As a new binder, pine sawdust was added into the pellets. The diameter of pellets was 20 mm in experiments and the compressive strength of them was up to 831 N when the addition ratio of biomass was 29%. The results showed that the overall iron recovery reached to 90% and the separated iron concentrate was up to 93.5% when the temperature is at 1423 K for 90 min with CaO addition ratio of 0.3. The process reduces the secondary environmental pollution of copper slag and will be applied well in the future.
Medical Economics: Legalize Organ Markets

The article argued to the contrary that at least insofar as organ transplants were concerned, this general assumption lied 180 degrees away from the truth. The first reaction of most concerned people, at the prospect of buying and selling human body parts, was one of revulsion. And, yet, this was the tried and true means that used for supplying more pedestrian goods and services. The article was the economic principles responsible for adequately making available to us such as items such as apples, shoes, and gardening services were the best ones in this case as well. The method was to argue that the institutions responsible for most goods and services in the economy that the last best hope for solving the problems that faced transplants of human body parts. The researchers consulted google scholar and mises.org and generated in this manner and cited almost a dozen publications which discussed the relevant subject matter and commented on several of them. It finds that Pro-organ sellers have a long way to go, but with determination and logic, one day the world will find a place for organs in the free-markets. And, then, many lives will be saved.
From music to emotions and tinnitus treatment, initial study

The extended tinnitus database consisting of 758 patients with information repeated from the original database of 555 patients, along with the addition of visits and a new questionnaire, the Tinnitus Function Index and Emotion Indexing Questionnaire, is used to mine for knowledge. New patients in the extended database represent those patients that have completed the Tinnitus Function Index questionnaire (TFI) [10]. The patient visits are separated and used for mining and action rule discovery based on all features and treatment success indicators including several new features tied to emotions (based on a mapping from TFI to Emotion Indexing Questionnaire (EIQ) [14]; EIQ questionnaire is used by our team to build personalized classifiers for automatic indexing of music by emotions). We propose a link between TFI and EIQ leading to a creation of new features in the extended tinnitus database. Then, we extract knowledge from this new database in the form of association action rules to assist with understanding and validation of diagnosis and treatment outcomes.
ON MONOTONIC CONVERGENCE OF HIGH ORDER ITERATIVE LEARNING UPDATE LAWS

Abstract High-order iterative learning control (ILC) in both iteration domain and time domain is investigated in this paper. We are interested in whether a high order iterative learning updating law is helpful in achieving a monotonic convergence in a suitable norm topology other than the exponentially weighted sup-norm. Discrete-time linear time invariant system is considered. With simulation illustrations, it is shown that a high-order scheme in both time domain and iteration domain is helpful. A new design framework for high order ILC is proposed.
Repetitive Head Impacts in Football Do Not Impair Dynamic Postural Control.

Purpose The purpose of this study was to assess the effect of repetitive head impacts experienced by football players compared to noncontact athletes on dynamic postural control during both single-task (ST) and dual-task (DT) conditions. Methods Thirty-four football players wearing accelerometer instrumented helmets and 13 cheerleaders performed a dynamic postural control battery, consisting of ST and DT gait initiation, gait, and gait termination, both prior to and following the football season. A 2 (group) × 2 (time) repeated measures ANOVA compared performance across 32 dynamic postural outcomes. A linear regression was performed on postural control change scores with common head impact kinematics serving as the independent variables. Results The football players experienced a mean of 538.1 ± 409.1 head impacts in the season with a mean linear acceleration of 27.8g ± 3.2g. There were no significant interactions for any of the ST or DT dynamic postural control tasks. There was a significant relationship between head impact kinematics and the lateral center of pressure displacement during the anticipatory postural adjustment phase (r = 0.26, P = 0.010) and transitional phase (r = 0.511, P = 0.042) during ST gait initiation. For both measures, the number of impacts exceeding 98g was the only significant predictor of decreased center of pressure displacement. Conclusions A single competitive football season did not adversely affect dynamic postural control when comparing football players to cheerleaders who do not experience repetitive head impacts. Furthermore, there were limited relationships with head impact kinematics suggesting that a single season of football does not adversely affect most outcome measures of instrumented dynamic postural control. These findings are consistent with most studies which fail to identify clinical differences related to repetitive head impacts.
Sorghum polyphenols and other bioactive components as functional and health promoting food ingredients

Abstract Sorghum is a versatile, drought and heat tolerant crop that fits well in sustainable production systems. Sorghum grain has attractive attributes highly relevant to modern food use, especially in relation to chronic disease prevention. The sorghum endosperm generally has a slower digesting starch profile than other cereal grains, which contributes to slowed gastric emptying and may thus benefit satiety and weight management. In addition, the diversity of phytochemicals in sorghum, especially the polyphenols, have been linked to various benefits, including improvements in glucose metabolism and insulin sensitivity, and lipid metabolism, as well as reduced fat accumulation, and markers of oxidative stress and inflammation in recent human trials. Despite the health benefits, the use of sorghum as a food ingredient severely lags its potential. The review focuses primarily on highlighting some of the challenges facing sorghum as a modern food ingredient, and discusses how the unique chemistry and properties of sorghum polyphenols can be exploited to improve food quality, while providing enhanced bioactive functionality.
Chronic Antibody-Negative Autoimmune Limbic Encephalitis: A Case Report (P5.384)

Objective: To describe a case of chronic antibody-negative autoimmune limbic encephalitis responsive to immunotherapy Background: Autoimmune limbic encephalitis is a relatively newly described entity, resulting in acute or subacute seizures, psychiatric symptoms, and memory deficits, often associated with autoantibodies with or without malignancy. Chronic antibody negative non-neoplastic limbic encephalitis has been poorly described in the literature. Design/Methods: Case report Results: A 67-year-old man began to show anterograde amnesia in 2013. An MRI of the brain showed hyperintense T2 signals in bilateral mesial temporal lobes with associated contrast enhancement. He was found to have sub-clinical left temporal seizures confirmed on long-term video EEG monitoring. Extensive work-up, including CSF analysis and paraneoplastic evaluation, was negative. He was treated with 5 days of IV steroids without improvement. Subsequently, he completed 1 cycle of plasmapheresis with marked clinical and radiographic improvement. He did well for 3 years, but then developed increased anterograde amnesia. Repeat MRI was concerning for recurrence of his encephalitis. He underwent another cycle of plasmapheresis without improvement. Repeat extensive diagnostic evaluation was only notable for elevated CSF IgG index. His symptoms continued to worsen and repeat MRI showed progression of mesial temporal signal change with contrast enhancement. PET/CT and CSF studies were again unrevealing. In 2017, he underwent a brain biopsy of the right temporal lesion, which revealed a non-specific lymphocytic infiltrate not felt to be neoplastic or infectious. A decision was made to start empiric therapy with cyclophosphamide. Since then he has had significant improvement in his ability to form new memories and care for himself with concurrent radiographic improvement. Conclusions: Chronic antibody-negative, non-neoplastic limbic encephalitis may respond to aggressive immunotherapy. Disclosure: Dr. Tollefson has nothing to disclose. Dr. Smith has nothing to disclose. Dr. Samkoff has nothing to disclose.
Behavioral Health Service Delivery with Latinos

In this chapter, we introduce readers to the Latinx population in the USA and provide suggestions for clinicians hoping to learn how to work more effectively with their Latinx clients. We begin by describing the heterogeneity of the Latinx population in the USA and discuss how historical, cultural, and adjustment experiences may be important to consider when providing treatment to Latinx clients. After describing the rich, diverse cultures that comprise the Latinx population, we provide suggestions for delivering behavioral health services to Latinx clients in an engaging and culturally informed manner. These suggestions are presented by phases of treatment, from pre-intake to termination. Although our recommendations are based on scholars who have devoted their careers to understanding the mental health needs of Latinx individuals in the USA, we caution our readers against making sweeping generalizations about Latinx clients based on cultural background alone. Instead, we encourage clinicians to consider how Latinx identity intertwines with other identities to impact each client’s lived experiences, and let this guide their approach to therapy.
Executive Summary: The Evolution of Entrepreneurship in Kansas City: A Visual Approach to Analyzing Entrepreneurial Development

Kansas City followed a markedly different path of economic development than more prominent entrepreneurial regions such as Silicon Valley or Boston’s Route 128. Kansas City’s life sciences and technology industries evolved primarily through entrepreneurial spin-off processes, and a few large firms and institutions played key roles in these processes. We have conducted an analysis of and visualized the entrepreneurial dynamics in the Kansas City region in a unique way. Key results are highlighted in this executive summary.
The Paleocene–Eocene Thermal Maximum: Plants as Paleothermometers, Rain Gauges, and Monitors

We travel back in time through this chapter and take a field trip to western North America during the Paleocene– Eocene Thermal Maximum (PETM), some 56 million years ago. Here, plant-and-animal fossils were discovered in the warmest interval of the last 500 million years, a condition that lasted only 200,000 years. We provide a brief review of what may have caused a massive influx of atmospheric carbon detected during the PETM. We contrast the PETM to similar ongoing thermal events that began during the Industrial Revolution and persist today. We discuss the tools that paleobotanists have devised to interpret climate from fossil leaf, pollen, and wood records, and present a brief overview of floral changes that occurred in western North America before, during, and right after this thermal maximum. Lastly, we explore how fossil data can be incorporated with ecological and systematic information into biogeographical models to predict how plants respond to climate change.
Preliminary Investigation into the regeneration of luminescent signal in nanoDot OSLDs.

PURPOSE Reuse of optically stimulated luminescent dosimeters (OSLDs) has been suggested in prior works by using a light source to erase the dosimeter's signal (optical bleaching) and recharacterizing the dosimeter's sensitivity based on its dose history. However, depending on the wavelength of the bleaching source and the dosimeter's dose history this may be problematic due to the presence of deep dosimetric traps and the phototransfer mechanism observed in Al2 O3 . In this work we examine the regeneration of signal in OSL nanoDots, with prior irradiation history, following their bleaching from a light source containing blue wavelengths. METHODS Irradiations were performed on 33 nanoDots at a dose range of 5-3000 cGy using 6 MV and 1000-3000 cGy using 220 kV x rays, with three nanoDots irradiated at each dose value. Following their irradiation, nanoDots were bleached using blue light for a period of 1 h. The postbleached signal in nanoDots was measured over a 27-day period to track any changes in their measured signal due to the migration of charge carriers from deep dosimetric traps to shallower traps of the dosimeter. RESULTS The growth extent and growth rate observed in bleached nanoDots were observed to be dependent on the dosimeter's accumulated dose history and energy of the radiation source. The 12 nanoDots with prior irradiation history of 500, 1000, 2000, and 3000 cGy from 6 MV x rays exhibit an increase in measured signal that range from 220 to 5229 PMT counts when measured the first day postbleaching to 408-8710 PMT counts when measured on the 27th day postbleaching, which may be substantial depending on the application regarding the dosimeter's reuse. CONCLUSION These findings caution against the reuse and optical bleaching of nanoDots with prior irradiation history exceeding 100 cGy and demonstrate an energy, accumulated dose, and time dependence in the regeneration of signal in postbleached nanoDots with prior irradiation history.
Interactive Multi-Robot Painting Through Colored Motion Trails

In this paper, we present a robotic painting system whereby a team of mobile robots equipped with different color paints create pictorial compositions by leaving trails of color as they move throughout a canvas. We envision this system to be used by an external user who can control the concentration of different colors over the painting by specifying density maps associated with the desired colors over the painting domain, which may vary over time. The robots distribute themselves according to such color densities by means of a heterogeneous distributed coverage control paradigm, whereby only those robots equipped with the appropriate paint will track the corresponding color density function. The painting composition therefore arises as the integration of the motion trajectories of the robots, which lay paint as they move throughout the canvas tracking the color density functions. The proposed interactive painting system is evaluated on a team of mobile robots with different experimental setups in terms of paints given to the robot team to highlight the effects and benefits of considering heterogeneous teams when there is a limited availability of painting resources.
The Arctic Subpolar Gyre sTate Estimate: Description and Assessment of a Data-Constrained, Dynamically Consistent Ocean-Sea Ice Estimate for 2002–2017

A description and assessment of the first release of the Arctic Subpolar gyre sTate Estimate (ASTE_R1), a medium-resolution data-constrained ocean-sea ice model-data synthesis spanning the period 2...
Cardiac extracellular volume fraction in cats with preclinical hypertrophic cardiomyopathy

BACKGROUND Cardiac magnetic resonance imaging (CMR) allows for detection of fibrosis in hypertrophic cardiomyopathy (HCM) by quantification of the extracellular volume fraction (ECV). HYPOTHESIS/OBJECTIVES To quantify native T1 mapping and ECV in cats. We hypothesize that native T1 mapping and ECV will be significantly increased in HCM cats compared with healthy cats. ANIMALS Seventeen healthy and 12 preclinical HCM, age-matched, client-owned cats. METHODS Prospective observational study. Tests performed included indirect blood pressure, CBC, biochemical analysis including total thyroid, urinalysis, transthoracic echocardiogram, and CMR. Cats were considered healthy if all tests were within normal limits and a diagnosis of HCM was determined by the presence of left ventricular concentric hypertrophy ≥6 mm on echocardiography. RESULTS There were statistically significant differences in LV mass (healthy = 5.87 g, HCM = 10.3 g, P < .0001), native T1 mapping (healthy = 1122 ms, HCM = 1209 ms, P = .004), and ECV (healthy = 26.0%, HCM = 32.6%, P < .0001). Variables of diastolic function including deceleration time of early diastolic transmitral flow (DTE), ratio between peak velocity of early diastolic transmitral flow and peak velocity of late diastolic transmitral flow (E : A), and peak velocity of late diastolic transmitral flow (A wave) were significantly correlated with ECV (DTE; r = 0.73 P = .007, E : A; r = -0.75 P = .004, A wave; r = 0.76 P = .004). CONCLUSIONS AND CLINICAL IMPORTANCE Quantitative assessment of cardiac ECV is feasible and can provide additional information not available using echocardiography.
Defective insulin-stimulated GLUT4 translocation in brown adipocytes induces systemic glucose homeostasis dysregulation independent of thermogenesis in female mice.

Abstract Objective Recent studies indicate that brown adipose tissue, in addition to its role in thermogenesis, has a role in the regulation of whole-body metabolism. Here we characterize the metabolic effects of deleting Rab10, a protein key for insulin stimulation of glucose uptake into white adipocytes, solely from brown adipocytes. Methods We used a murine brown adipocyte cell line and stromal vascular fraction-derived in vitro differentiated brown adipocytes to study the role of Rab10 in insulin-stimulated GLUT4 translocation to the plasma membrane and insulin-stimulated glucose uptake. We generated a brown adipocyte-specific Rab10 knockout for in vivo studies of metabolism and thermoregulation. Results We demonstrate that deletion of Rab10 from brown adipocytes results in a two-fold reduction of insulin-stimulated glucose transport by reducing translocation of the GLUT4 glucose transporter to the plasma membrane, an effect linked to whole-body glucose intolerance and insulin resistance in female mice. This effect on metabolism is independent of the thermogenic function of brown adipocytes, thereby revealing a metabolism-specific role for brown adipocytes in female mice. The reduced glucose uptake induced by Rab10 deletion disrupts ChREBP regulation of de novo lipogenesis (DNL) genes, providing a potential link between DNL in brown adipocytes and whole-body metabolic regulation in female mice. However, deletion of Rab10 from male mice does not induce systemic insulin resistance, although ChREBP regulation is disrupted. Conclusions Our studies of Rab10 reveal the role of insulin-regulated glucose transport into brown adipocytes in whole-body metabolic homeostasis of female mice. Importantly, the contribution of brown adipocytes to whole-body metabolic regulation is independent of its role in thermogenesis. It is unclear whether the whole-body metabolic sexual dimorphism is because female mice are permissive to the effects of Rab10 deletion from brown adipocytes or because male mice are resistant to the effect.
Aberrant Lumbopelvic Movements Predict Prospective Functional Decline in Older Adults with Chronic Low Back Pain.

ABSTRACT Objective To investigate if clinically observable aberrant lumbopelvic movements are associated with physical function at 12-month follow-up in older adults with chronic low back pain (CLBP), both directly and indirectly through baseline physical function. Design Secondary analysis of a yearlong prospective cohort study. Setting Clinical Research Laboratory. Participants Community-dwelling older adults with CLBP. Interventions Not applicable. Main Outcome Measures Data from 239 participants were analyzed. Participants were screened at baseline for aberrant lumbopelvic movements during active trunk flexion; total observable aberrant movements were recorded and summed (range 0-4). Latent constructs of physical function were developed from an array of perception-based and performance-based outcome measures at baseline and 12-months, respectively. Structural Equation Modeling was used to assess the direct effect of baseline aberrant movement score on the latent construct of 12-month physical function, and its indirect effect through baseline physical function. Results Aberrant movements were present in the majority of participants (64.9%) and had a significant negative total effect on 12-month physical function (γ= -0.278, p Conclusion Aberrant lumbopelvic movements are associated with decreased physical function at 12-month follow-up in older adults with CLBP, independent of baseline physical function and covariates. Future studies should evaluate if screening for aberrant movements may inform prognostic and interventional efforts in this patient population.