cssi/SciSciGPT-SciSciNet huggingface dataset:
Phase Transitions in RbCaF3and KCaF3

Calculations have been performed to determine the lowest static energy configurations associated with R-pint lattice instabilities in RbCaF3 and KCaF3. Minimum static energies and ionic displacements have been obtained for rotations of the Fluorine octahedra about the [1, 0, 0] [1, 1, 0] and [1, 1, 1] directions. Lattice configurations and energy minima will be discussed and compared with experimental values.
Attention Deficit Disorder (ADD): Methylphenidate Treatment

The clinical response to three dose levels of methylphenidate (5, 10, and 15 mg BID) in 23 children with ADD+H and 17 children with ADD-H is reported from the Department of Psychiatry, University of Massachusetts Medical Center, Worcester, MA.
What Are the Most Powerful Immunogen Design Vaccine Strategies? A Structural Biologist’s Perspective

The ability of structure-based design to control the shape and reactivity-the atomic-level chemistry-of an immunogen argues for it being one of the "most powerful" immunogen-design strategies. But antigenic reactivity is only one of the properties required to induce a protective immune response. Here, a multidimensional approach is used to exemplify the enabling role atomic-level information can play in the development of immunogens against three viral pathogens, respiratory syncytial virus, influenza A virus, and human immunodeficiency virus (HIV), which have resisted standard approaches to vaccine development. Overall, structure-based strategies incorporating B-cell ontogenies and viral evasion mechanisms appear exceptionally powerful.
Parallax Views on a Prophet, Properly Understood: Margaret Stout and Jeannine M. Love. Integrative Process: Follettian Thinking from Ontology to Administration. Anoka, MN: Process Century Press, 2015.

Mary Parker Follett was a writer well ahead of her times, then and still; enigmatic in ways that may partially explain her itinerant popularity since the pinnacle of her success and acclaim in the ...
My Beloved is a Bass Line: Musical, "De-colonial" Interventions in Song Criticism and Sacred Erotic Discourse

What meanings might be composed from the Song of Song’s amatory and horticultural language if it is read with a sense of love as irreducibly “de-colonial”? For Chela Sandoval, (2000) ‘true love’ resides in the “double consciousness”, interstitial agency and “tactical sign-reading” with which colonised subjects deconstruct “Euro-American artifacts” like 'love,' 'soul,' 'knowledge' to then redefine them in de-colonial terms. I construct a womanist intertextual matrix for the Song to illustrate how productive this hermeneutic shift might be. In Alice Walker’s search for her foremothers’ gardens (1983), gardens and songs compose an ambivalent metonymic economy. Songs as gardens and gardens as songs trigger haunted longing; they are goads for remembrance, rebellion and public grieving. Toni Morrison’s ‘commentary’ on the Song ( Beloved) circulates similar de-colonial energies. Such intertexts chasten the whiteness not only of earlier resistant readings that mobilised the Song to contest the heteronormative politics of love as a cultural practice, but also 1) Boer’s utopian reading of the Song’s agricultural economy as self-generating plenitude (2007); 2) Black’s construal of the Shulammite’s blackness as a non-racialised opacity that affords romantic agency (2006). De-colonial intertexts beg re-signification of the Song’s musicality, its garden imagery, its female protagonist’s blackness and vineyard migrations in terms that critically intervene in the racial and economic politics of love as a cultural practice. Additionally, given that music figures centrally in Walker’s, Morrisons’s and Sandoval’s genealogies of love, a de-colonial reading of the Song mandates construction of a subaltern musical archive within the Eurocentric discourse of sacred eroticism which the Song subtends as an ur-text: if the Shulammite’s erotic longing and seeking are re-read as de-colonial and “trickster”-esque, she begets a subaltern musical family tree—audible today, I shall argue, in the ‘shulammitc’ bass-playing and protest-singing of Meshell Ndegeocello,.
TAp63γ and ΔNp63γ are regulated by RBM38 via mRNA stability and have an opposing function in growth suppression

// Wensheng Yan 1 , Yanhong Zhang 1 and Xinbin Chen 1 1 The Comparative Oncology Laboratory, Schools of Veterinary Medicine and Medicine, University of California at Davis, Davis, California, USA Correspondence to: Xinbin Chen, email: // Keywords : p63, p63γ, RBM38, RNA binding protein, mRNA stability Received : April 19, 2017 Accepted : April 23, 2017 Published : June 13, 2017 Abstract The p63 gene is expressed as TAp63 from the P1 promoter and as ΔNp63 from the P2 promoter. Through alternative splicing, five TA and five ΔN isoforms (α-e) are expressed. Isoforms α-β and δ share an identical 3’ untranslated region (3’UTR) whereas isoform γ has a unique 3’UTR. Recently, we found that RBM38 RNA-binding protein is a target of p63 and RBM38 in turn regulates p63α/β expression via mRNA stability. However, it is uncertain whether p63γ has a unique biological activity and whether p63γ is regulated by RBM38. Here, we found that the levels of ΔNp63γ transcript and protein are induced upon overexpression of RBM38 but decreased by RBM38 knockdown. Conversely, we found that the levels of ΔNp63β transcript and protein are decreased by ectopic expression of RBM38 but increased by RBM38 knockdown, consistent with our previous report. Interestingly, RBM38 increases the half-life of p63γ mRNA by binding to a GU-rich element in p63γ 3’UTR. In contrast, our previous studies showed that RBM38 decreases the half-life of p63α/β mRNAs by binding to AU-/U-rich elements in their 3’UTR. We also found that knockout of p63γ in ME180 and HaCaT cells, in which ΔNp63 isoforms are predominant, inhibits cell proliferation and migration, suggesting that ΔNp63γ has a pro-growth activity. In contrast, we found that knockout of TAp63γ in MIA PaCa-2 cells, in which TAp63 isoforms are predominant, promotes cell proliferation, migration, and inhibits cellular senescence. Taken together, we conclude that ΔNp63γ has an oncogenic poten­tial whereas TAp63γ is a tumor suppressor.
Speech dereverberation and denoising using complex ratio masks

Traditional speech separation systems enhance the magnitude response of noisy speech. Recent studies, however, have shown that perceptual speech quality is significantly improved when magnitude and phase are both enhanced. These studies, however, have not determined if phase enhancement is beneficial in environments that contain reverberation as well as noise. In this paper, we present an approach that jointly enhances the magnitude and phase of reverberant and noisy speech. We use a deep neural network to estimate the real and imaginary components of the complex ideal ratio mask (cIRM), which results in clean and anechoic speech when applied to a reverberant-noisy mixture. Our results show that phase is important for dereverberation, and that complex ratio masking outperforms related methods.
Courses of Empire: Ecological Apocalypse in Early American Literature

Echoing their European roots, the writings of early American writers hold a strongly anthropocentric viewpoint, but by the early national era, they begin to reflect modern science and challenge long held conceptions about the centrality of humans in the cosmos. I begin the chapter with an overview of work by American Indians, the essence of which challenges European anthropocentrism. The poetry of William Cullen Bryant and paintings of Thomas Cole Americanize European ideas about fallen civilizations and ruins, and, though fully romantic, decenter humanity as the end of the universe. Transcendentalists such as Emerson and Thoreau, echoing Wordsworth and other European romantics, elevate humans as divine, but their views are far from anthropocentric. Writers such as Hawthorne and Melville operate more skeptically and metaphysically in problematizing anthropocentrism.
The engineering student identity scale a cross disciplinary exploration of factor structure

To correctly engage in the instrument development process takes time. According to Benson's model of construct validation (1) there are at least three lengthy stages (substantive, structural, external) to construct validation when developing a new measure. This study examines how instrument structure impacts the validation process and what it can tell us about instrument revision. In this study we will take a closer look at the development of the Engineering Student Identity Scale (ESIS). After engaging in the in-depth substantive stage of instrument development, the instrument developers began the process of examining whether the anticipated factor structure of the measure fit the observed data. Results from a series of CFA analyses indicated that none of the hypothesized models fit the observed data. While instrument revision at any stage of development is important and likely to lead to a better measure, it is important to gather as much information as possible from each stage to guide revisions. In an effort to better understand how the items on the ESIS instrument function together, a cross-disciplinary team of psychology and engineering experts conducted a series of CFAs and an EFA to examine the factor structure present in the observed data. Initial results support a six-factor structure. Implications for the next round of instrument development are discussed.
Cross-Generalization Profile to Orosensory Stimuli of Rats Conditioned to Avoid a High Fat/High Sugar Diet

The orosensory characteristics of a diet play a role in its acceptance and rejection. The current study was designed to investigate the gustatory components that contribute to the intake of a palatable, high-energy diet (HE; 45% calories from fat, 17% calories from sucrose). Here, rats were conditioned to avoid HE diet by pairings with i.p. injections of LiCl to induce visceral malaise. Subsequently, the degree of generalization was tested to an array of taste compounds using a brief-access lick procedure (10-s trials, 30-min sessions). Compared to NaCl-injected controls, LiCl-injected rats suppressed licking response to 100% linoleic acid and 20% intralipid, and to a lesser extent 17% sucrose. There was more variability in the lick responses to sucrose among the LiCl-injected rats. Rats that tended to suppress licking responses to sucrose generalized this response to glucose, fructose and Na-saccharin but not to Polycose. In contrast, LiCl-injected rats did not significantly suppress lick responses to water, NaCl, citric acid, or quinine compared to controls rats. The brief access feature of this procedure, allows for behavioral measures when postingestive factors are minimized. These findings support a role for gustatory cues in the detection of high fat/high sugar diets. Furthermore, it appears that the fat component is a more salient orosensory feature of the HE diet.
Cellulitis: definition, etiology, diagnosis and treatment.

A definition of cellulitis, explanation of its cause, and directions on how to diagnose and treat it. . Virtual Mentor is a monthly bioethics journal published by the American Medical Association.
Blunt Chest Trauma

Blunt chest trauma is defined as trauma in which the primary injury does not produce an open communication between the intrathoracic contents and the environment [276]. In most publications that discuss chest trauma in civilian populations, patients with blunt chest trauma significantly outnumber patients with penetrating chest trauma [9, 39, 277]. Motor vehicle accidents are responsible for the vast majority of blunt chest trauma encountered in most trauma centers [15, 21, 277]; falls, assaults, and crush and blast injuries account for the remaining, smaller number of cases.
Uncertainty Quantification in Robust Inference for Irregularly Spaced Spatial Data Using Block Bootstrap

This paper deals with uncertainty quantification (UQ) for a class of robust estimators of population parameters of a stationary, multivariate random field that is observed at a finite number of locations s1,…, sn, generated by a stochastic design. The class of robust estimators considered here is given by the so-called M-estimators that in particular include robust estimators of location, scale, linear regression parameters, as well as the maximum likelihood and pseudo maximum likelihood estimators, among others. Finding practically useful UQ measures, both in terms of standard errors of the point estimators as well as interval estimation for the parameters is a difficult problem due to presence of inhomogeneous dependence among irregularly spaced spatial observations. Exact and asymptotic variances of such estimators have a complicated form that depends on the autocovariance function of the random field, the spatial sampling density, and also on the relative rate of growth of the sample size versus the volume of the sampling region. Similar complex interactions of these factors are also present in the sampling distributions of these estimators which makes exact calibration of confidence intervals impractical. Here it is shown that a version of the spatial block bootstrap can be used to produce valid UQ measures, both in terms of estimation of the standard error as well as interval estimation. A key advantage of the proposed method is that it provides valid approximations in very general settings without requiring any explicit adjustments for spatial sampling structures and without requiring explicit estimation of the covariance function and of the spatial sampling density.
Abstract WP242: Modeling Prevention, Prediction or Explanation of Stroke Risk: Insights From Meta-Analysis of Studies With Models Predicting Stroke or Composite Outcomes

Objective: Models predicting stroke suffer from several problems: they are not accurate, contain mostly non-modifiable factors, and they explain more than they predict. We performed a meta-analysis...
GPCR Signaling Regulation: The Role of GRKs and Arrestins

Every animal species expresses hundreds of different G protein-coupled receptors (GPCRs) that respond to a wide variety of external stimuli. GPCRs-driven signaling pathways are involved in pretty much every physiological function and in many pathologies. Therefore, GPCRs are targeted by about a third of clinically used drugs. The signaling of most GPCRs via G proteins is terminated by the phosphorylation of active receptor by specific kinases (GPCR kinases, or GRKs) and subsequent binding of arrestin proteins, that selectively recognize active phosphorylated receptors. In addition, GRKs and arrestins play a role in multiple signaling pathways in the cell, both GPCR-initiated and receptor-independent. Here we focus on the mechanisms of GRK- and arrestin-mediated regulation of GPCR signaling, which includes homologous desensitization and redirection of signaling to additional pathways by bound arrestins.
Quantitative Assessment of the Obliquity of the First Metatarsal-Medial Cuneiform Articulation.

Abstract The so-called obliquity of the first metatarsal-medial cuneiform articulation has been described as an atavistic trait of human foot morphology, and it is commonly proposed as a relative risk factor for development of the hallux abductovalgus (HAV) deformity. The objectives of this investigation were to 1) provide descriptive normative radiographic data on a series of first metatarsal-medial cuneiform articulations and 2) correlate these findings to other common radiographic parameters used to define the HAV deformity. We measured radiographic parameters including the first intermetatarsal angle, hallux abductus angle, tibial sesamoid position, Engel's angle, and 2 measures of obliquity in the transverse and sagittal planes on a consecutive series of 136 weightbearing foot radiographic projections from subjects without a history of foot/ankle surgery or fracture/dislocation. Measurements were considered as continuous variables, graphically depicted against each other on frequency scatter plots, and analyzed by means of Pearson correlation coefficients. Only 1 bivariate comparison demonstrated a weak negative correlation (Engel's angle versus Obliquity_1 [Pearson –0.259; p = .002]). The results of this investigation did not demonstrate a statistically significant or clinically substantial relationship between the obliquity of the first metatarsal-cuneiform joint and common radiograph parameters of the HAV deformity. Although not specifically studied here, these results might potentially indicate function, as opposed to structure, in the developmental pathogenesis of the HAV deformity.
Rapid Synthesis of Fused N‐Heterocycles by Transition‐Metal‐Free Electrophilic Amination of Arene C—H Bonds.

The synthesis of fused N-heterocycles starting from readily available 2-nitrobiaryls and phenylmagnesium bromide is disclosed.
Abstract #5284: Interaction of estrogen with stimulating and inhibiting signaling pathways of lung adenocarcinoma

Small airway-derived pulmonary adenocarcinoma (PAC) is the leading type of lung cancer today and women are at a higher risk than men to develop PAC. We have shown that the nicotine-derived nitrosamine NNK stimulates the growth and migration of PAC cells in vitro by cAMP-mediated signaling downstream of \#946;1-adrenoreceptors (\#946;1-ARs) and that estrogen enhances the effectiveness of this pathway by signaling via the estrogen receptor beta (ER\#946;). Our current data demonstrate that the observed cooperation between NNK and estrogen-induced stimulating signaling in the cells of origin of PAC involves the formation of a \#946;1-AR/ER\#946; complex. Transfection with oncogenic Ras12V enhanced this cooperative signaling while transfection with dominant negative 17N Ras blocked this pathway. Transfection of cells with the regulator of G-protein signaling 5 (RGS5) reduced while blockade of the inhibitory G-protein G\#945;1 by pertussis toxin (PTX) significantly enhanced signaling responses. The neurotransmitter \#947;-aminobutyric acid (GABA) completely blocked cAMP formation and its downstream responses an effect mediated by the G\#945;i-coupled GABAB receptor. Studies are currently underway to investigate if chronic exposure to estrogen suppresses GABA in small airway epithelial cells. The resulting dual estrogenic influence on PAC development by enhaned \#946;1-AR signaling and deficient inhibitory GABA signaling would provide a pulmonary microenvironment that selectively supports the development of PAC in women. Supported by a contract with the National Lung Cancer Partnership. Citation Information: In: Proc Am Assoc Cancer Res; 2009 Apr 18-22; Denver, CO. Philadelphia (PA): AACR; 2009. Abstract nr 5284.
Accuracy and reliability of the expected root position setup on clinical decision making of root position at midtreatment.

Introduction Accurate root position is imperative for successful orthodontic treatment that is stable and functional. Current methods to monitor root position are either inaccurate or use relatively high levels of radiation. A method to generate an expected root position (ERP) setup has been reported to have the potential to accurately evaluate root position with minimal radiation. The purpose of this study was to determine the accuracy and reliability of the clinical decisions made on root position using the ERP setup. Methods This retrospective study included 10 subjects who had pretreatment and midtreatment cone-beam computed tomography (CBCT) scans and study models. An ERP setup was generated for all patients at midtreatment. Four examiners assessed both the CBCT scan and ERP setup and made clinical decisions regarding the root position with each method. Cohen's kappa was determined to assess intraoperator and intermethod reliability. Sensitivity, specificity, positive predictive value, and negative predictive value were calculated to determine the accuracy of the ERP setup. Results The kappa values for intraoperator reliability for both the CBCT scan and ERP setup fell within the 0.61-0.80 range. The kappa values for intermethod reliability between the CBCT scan and ERP setup fell within the 0.61-0.80 range for all tooth groups. The sensitivity of the ERP setup ranged from 0.72 to 0.90, specificity ranged from 0.89 to 0.97, positive predictive value ranged from 0.57 to 0.85, and negative predictive value ranged from 0.93 to 0.99. Conclusions This study demonstrated that the ERP setup, when compared with the gold standard CBCT scan, was accurate and reliable in making clinical decisions regarding root position at midtreatment.
Aberrant salivary gland tissue in mandible

Abstract A case of aberrant salivary gland in the mandible has been reported. It appears that there is no way to diagnose this condition except by biopsy. Because of the paucity of literature on salivary gland tissue found within the mandible, this case has been reported. Only two other cases have been found in the literature.1, 2
Identifying Important Risk Factors Associated with Vehicle Injuries Using Driving Behavior Data and Predictive Analytics

Road injuries are rated among the top 10 causes of death by the World Health Organization, and the only one that is not a disease. The total economic cost of motor vehicle crashes in the United States was estimated to be $242 billion a year. This study examines multiple factors of accidents simultaneously with a goal of generating an interpretable model that can predict the occurrence of an accident given road conditions and driver behavior. The study compared 4 machine learning and deep learning modeling techniques on a dataset of 7707 trips collected by the Second Strategic Highway Research Program. A gradient boosted model was found to be most accurate and interpretable in accident prediction. This modeling technique also allows us to rank the feature importance of the factors in the model. The study finds that driver behavior, pre-incident maneuvers and secondary task duration are the most important variables in the predictive model. Using these conclusions will allow us to perform more work to infer these accident causes directly from vehicle sensor data in the future.
Machine Learning-based Prediction for Dynamic, Runtime Architectural Optimizations of Embedded Systems

Embedded systems have been becoming increasingly complex over recent years, with performance becoming comparable to desktop computing systems. However, embedded systems need to adhere to greater design constraints (e.g., area and energy constraints) compared to desktop computing systems. Architectural specialization is a technique that can aid in meeting the stringent design constraints by introducing configurable hardware that can be tuned at runtime to optimize a goal (e.g., minimum energy, minimum execution time) for an application. However, traditional approaches (i.e., exhaustive, heuristic searches) often take considerable time to search a large design composed of different configurable parameters (e.g., cache size, associativity, etc.) and parameter values (e.g., 4 kB, 2-way, etc.). In addition, the presence of application phases (i.e., repeating execution behavior) allow for finer-grained tuning at the cost of even greater exploration overhead. In this paper, we apply machine learning to reduce/eliminate the design space exploration overhead associated with finding the best set of configurable parameters for configurable L1 instruction and data caches. Our prediction methodology consists of artificial neural networks (ANNs) which take the execution statistics of an application phase as input and outputs a best cache configuration (i.e., combination of configurable parameter values) for the instruction and data caches). Our results show that we can achieve an average energy degradation of less than 5% for the instruction and data caches with an average of 20% phase misclassification percentage and 20% less cache switches than the case where the best cache configuration is chosen for every application phase.
Structure of the Cardiac Sodium Channel

Summary Voltage-gated sodium channel Nav1.5 generates cardiac action potentials and initiates the heartbeat. Here, we report structures of NaV1.5 at 3.2–3.5 A resolution. NaV1.5 is distinguished from other sodium channels by a unique glycosyl moiety and loss of disulfide-bonding capability at the NaVβ subunit-interaction sites. The antiarrhythmic drug flecainide specifically targets the central cavity of the pore. The voltage sensors are partially activated, and the fast-inactivation gate is partially closed. Activation of the voltage sensor of Domain III allows binding of the isoleucine-phenylalanine-methionine (IFM) motif to the inactivation-gate receptor. Asp and Ala, in the selectivity motif DEKA, line the walls of the ion-selectivity filter, whereas Glu and Lys are in positions to accept and release Na+ ions via a charge-delocalization network. Arrhythmia mutation sites undergo large translocations during gating, providing a potential mechanism for pathogenic effects. Our results provide detailed insights into Nav1.5 structure, pharmacology, activation, inactivation, ion selectivity, and arrhythmias.
Structure and Reaction Mechanism of YcjR, an Epimerase That Facilitates the Interconversion of d-Gulosides to d-Glucosides in Escherichia coli

YcjR from Escherichia coli K-12 MG1655 catalyzes the manganese-dependent reversible epimerization of 3-keto-α-d-gulosides to the corresponding 3-keto-α-d-glucosides as a part of a proposed catabolic pathway for the transformation of d-gulosides to d-glucosides. The three-dimensional structure of the manganese-bound enzyme was determined by X-ray crystallography. The divalent manganese ion is coordinated to the enzyme by ligation to Glu-146, Asp-179, His-205, and Glu-240. When either of the two active site glutamate residues is mutated to glutamine, the enzyme loses all catalytic activity for the epimerization of α-methyl-3-keto-d-glucoside at C4. However, the E240Q mutant can catalyze hydrogen-deuterium exchange of the proton at C4 of α-methyl-3-keto-d-glucoside in solvent D2O. The E146Q mutant does not catalyze this exchange reaction. These results indicate that YcjR catalyzes the isomerization of 3-keto-d-glucosides via proton abstraction at C4 by Glu-146 to form a cis-enediolate intermediate that is subsequently protonated on the opposite face by Glu-240 to generate the corresponding 3-keto-d-guloside. This conclusion is supported by docking of the cis-enediolate intermediate into the active site of YcjR based on the known binding orientation of d-fructose and d-psicose in the active site of d-psicose-3-epimerase.
Laparoscopic Double Cholecystectomy in a Pediatric Patient for Gallbladder Duplication: An Unusual Case of Biliary Anatomy

Gall bladder duplication is a rare congenital anomaly that can be identified clinically during the workup for gall bladder-related symptoms. This anatomic variation can complicate surgery, and yet there are few published reports of this variant causing symptoms in pediatric patients. This is a case of a 17-year-old female with a history of Arnold-Chiari malformation type I, presenting with right upper quadrant pain. Outside computed tomography reported a trilobed gall bladder, while magnetic resonance cholangiopancreatography demonstrated a duplicated gall bladder. Endoscopic resonance cholangiopancreatography (ERCP) showed a rare anatomic variant of duplicated gall bladder with an accessory right hepatic duct branching off the cystic duct. Due to complex anatomy, both indocyanine green and intraoperative cholangiogram (IOC) were utilized for a successful laparoscopic cholecystectomy. Only ERCP and IOC were able to clearly identify the aberrant right hepatic duct. Final pathology confirmed acute and chronic cholecystitis without dysplasia or cholelithiasis. This case highlights a rare anomaly of an aberrant right hepatic duct in the setting of gallbladder duplication in a pediatric patient. We would recommend both ERCP and IOC during the laparoscopic surgical approach as they were the only imaging modalities to identify the patient's correct anatomy, likely due to the size of pediatric biliary structures.
Mechanisms of investment safety management under sustainable development: interpretation of the essence of concepts

The article states that attracting investments in the financial sector of the economy can lead to a number of consequences: legislative, organizational and institutional, which can lead to socio-economic problems (increase in debt, loss of control over national strategic assets, etc.). Approaches to defining the concepts of «security», «investment security», «mechanism of state security management», «sustainable development» are considered. The definition of security, investment security, state security management mechanism, investment security management mechanism, sustainable development, and investment security management mechanism in the conditions of sustainable development is given. It is determined that the main components of economic security of Ukraine are: macroeconomic, financial, foreign economic, investment, scientific and technological, energy, industrial, demographic, social, food security. It has been proven that investment security is one of the important components of economic security. The main threats that adversely affect the state of investment security in the country are outlined, as well as a number of compliance requirements that will help to minimize the threats. The obligatory structural components are proposed, which should include the state mechanism of providing investment security in the conditions of sustainable development, namely: monitoring as an information and analytical system of monitoring the dynamics of economic and financial security indicators of the country; the activity of the state to prevent threats to investment security and to compensate for the losses incurred due to exceeding the limit values for these or other security indicators; the activity of the state to identify and prevent internal and external threats to the investment security of the economy; activities of the state to prevent negative impact on the environment.
Abstract TMP110: Outcomes After Intracerebral Hemorrhage in Patients With Arteriovenous Malformations

Background: Few population-level data exist regarding functional outcomes after intracerebral hemorrhage (ICH) caused by a ruptured cerebral arteriovenous malformation (AVM). Our aim was to compare outcomes after ICH from AVM rupture versus other causes of ICH.Methods: We performed a retrospective p
A weighted multi-output neural network model for the prediction of rigid pavement deterioration

A novel weighted multi-output neural network (NN) model is proposed for predicting the deterioration of rigid pavements based on Iowa pavement management system data. This first-of-a-kind model sim...
Dermatologic support for oncology: Quantifying the consultative services received by hospitalized oncology patients.

Hospitalized oncology patients often require multidisciplinary care. Inpatient consultative dermatologists can provide expertise in the management of cutaneous complications that patients with cancer may experience. The goal of this study was to quantify the types of consults received by hospitalized oncology patients to better understand the utilization of dermatology consults in this population. Hospital billing codes were used to identify inpatient oncology patients and the types of consults they received at a single quaternary care hospital center. Between July 1, 2015, and January 31, 2020, 14,175 patients were admitted to an oncology service for more than 24 hours, and 5,243 (37%) of these patients received at least 1 consultation during their hospital admission. These patients received a total of 10,492 consults from 101 different services. Dermatology had the fifth-highest number of consults (n = 623; 5.9%). Among patients receiving consults, 608 (11.6%) received inpatient dermatology consults. Infectious disease was the service with the most consults (n = 1,485; 14.2%) and was also the service most commonly co-consulted with dermatology (n = 262; 42.1%). The inpatient consultative dermatology service is highly utilized among hospitalized oncology patients, suggesting that expertise in dermatologic care is valued by oncology teams.
ALL-414: Obesity is Not Associated with an Increased Risk of Venous Thromboembolism in AYA Patients with Acute Lymphoblastic Leukemia

Context: Acute venous thromboembolisms (VTEs) are a serious complication during intensive chemotherapy. Risk factors associated with VTEs, specifically in the adolescent and young adult (AYA) population being treated per pediatric protocols for acute lymphoblastic leukemia (ALL), are poorly described in the literature. Objective: To determine whether baseline demographic data, specifically obesity and asparaginase dose, are risk factors for VTEs in AYA patients. Design, Setting, and Patients: Patients were studied retrospectively from 2009 to 2020. Tertiary referral center. A cohort of 66 adolescent and young adult patients, ages 15 to 26 years, with previously untreated ALL was identified and divided into groups based on the presence or absence (controls) of VTEs during ALL treatment. All patients were treated with Berlin-Frankfurt-Munster (BFM)-based pediatric chemotherapy protocols. Main Outcome Measures: We hypothesized that AYA patients being treated per BFM-based pediatric protocols experience similar or higher rates of VTEs as the pediatric ALL population and that the risk of developing a VTE is increased in patients as body mass index (BMI) and asparaginase dose increases. Results: Fourteen patients (21%) experienced 17 VTEs. The majority of VTEs occurred during induction chemotherapy (47%), after asparaginase administration (88%), in the upper extremities (59%), were associated with a CVC (53%), and were treated with anticoagulation (94%). BMI or asparaginase dose during induction chemotherapy were not predictive of VTE risk (p=0.9). There were no statistical differences in age at diagnosis, sex distribution, race/ethnicity distribution, other treatment-related morbidities, relapse-free survival (79% vs 81% at 5 years), and overall survival (93% vs 81% at 5 years) in patients who experienced a VTE compared to controls. Conclusions: AYA patients with ALL experienced similar rates of VTE as their pediatric counterparts. Unlike adults with cancer, increased BMI and asparaginase dose were not associated with an elevated risk of VTE. Given the limited study size and retrospective nature of this study, future prospective studies are indicated before this information is appropriate for clinical application.
DISTRIBUTED TRAFFIC CONTROL SYSTEM

Abstract The newly developed distributed train traffic control system adopting micro-computers is introduced, in contrast to the conventional system, which integrates signal control distributed at stations into the operation dispatching center using remote-control apparatus. In the new system, the micro-computers installed at each station control signals following to the train timetable, and the central computer at the operation dispatching center manages the train schedule through the whole line and transmits the train timetable data of operation plan or operation changes, in place of signal control data, to the micro-computers at stations. The authors start the test operation of the prototype equipment for one station.
Adrian, Edgar Douglas

Sir Edgar Douglas Adrian (1889–1977) was one of the most influential neuroscientists of the twentieth century. His discoveries included explaining the relationship between the intensity of nerve stimulation to the nature of muscle contraction, the role of the brain in sensory perception, and that the sensory nerve impulses from the afferent fibers ended in the thalamus and by mapping the cortex, one can gauge the distribution of brain representation. Adrian shared the 1932 Nobel Prize in medicine and physiology with Sir Charles Sherrington; they were honored “for their discoveries regarding the functions of neurons.”
Toxicity Testing, Developmental

Teratology, the original term for the study of birth defects, is now better designated developmental toxicology. Developmental toxicity is defined as any structural or functional alteration caused by environmental insult that interferes with normal growth, differentiation, development, and/or behavior. The US Food and Drug Administration promulgated Segment I–III testing guidelines in 1966 to evaluate developmental reproductive effects of drugs under development during prebreed, mating, gestation, and lactation. Risk assessment by the US government is based on (1) basic scientific research (hazard identification), (2) science-based toxicity risk assessment (animal dose–response assessment), (3) human exposure assessment, and (4) risk characterization.
Diamonds Are Forever: Sparkling Rings of Star Formation in an HI Setting

With the launch of the GALEX satellite, UV emission has been detected well outside the optical disks of galaxies, yielding the possibility of studying star formation in extreme environments -- outside the optical extents of these systems. We present HI observations of galaxies that show UV rings well outside their optical bodies in order to learn if and how the HI is related to the UV emission.
Norm Based Robust Dynamic Feedback Control of Constrained Systems

Abstract Most realistic control problems involve both some type of time-domain constraints and model uncertainty, However. the majority of controller design procedures currently available focus only on one aspect of the problem. with only a handful of methods capable of simultaneously addressing. albeit in a limited fashion. both issues, In this paper we propose a framework that takes explicitly into account both time domain constraints and model uncertainty. Specifically. We use a operator norm approach to define a simple robustness measure for constrained systems, The available degrees of freedom are then used to optimize this measure subject to additional performance specifications. We believe that the results presented here provide a useful new approach for designing controllers capable of yielding good performance under substantial uncertainty while meeting design constraints
DO CAPITAL TAX INCENTIVES ATTRACT NEW BUSINESSES? EVIDENCE ACROSS INDUSTRIES FROM THE NEW MARKETS TAX CREDIT

All levels of government pursue policies to attract new businesses with the hope that these enterprises will create local economic growth. In this paper, we use the New Markets Tax Credit (NMTC) to determine the effect of a capital tax credit on where firms in different types of industries locate. When estimating the impact of the NMTC on business location, there are likely to be unobservable local characteristics that are correlated with where businesses choose to open that would cause OLS estimates to be biased. To control for the endogenous selection, we use a plausibly exogenous eligibility cutoff and compare census tracts that are just eligible for the tax credit to those that are just ineligible. Using data from the Dun and Bradstreet MarketPlace Files, we find that in Metropolitan Statistical Areas, the NMTC incentivized new businesses to locate in tracts that were eligible for the tax credit in 2002 and 2004. However, we find that in 2006 the tax credit deterred new establishments. When we stratify the 2006 sample by industry, we find that this capital tax credit attracted more capital intensive industries, such as manufacturing, while deterring more labor intensive industries, such as services. Our results are important to policy makers, as we find that the type of tax credit offered causes a sorting of different industries across locations.
A central role for HSC70 in regulating antigen trafficking and MHC class II presentation.

Cells rely on multiple intracellular trafficking pathways to capture antigens for proteolysis. The resulting peptides bind to MHC class II molecules to promote CD4+ T cell recognition. Endocytosis enhances the capture of extracellular and cell surface bound antigens for processing and presentation, while autophagy pathways shunt cytoplasmic and nuclear antigens for presentation in the context of MHC class II molecules. Understanding how physiological changes and cellular stress alter antigen trafficking and the repertoire of peptides presented by class II molecules remains challenging, yet important in devising novel approaches to boost immune responses to pathogens and tumors. An abundant, constitutively expressed cytoplasmic chaperone, HSC70 plays a central role in modulating antigen transport within cells to control MHC class II presentation during nutrient stress. HSC70 may serve as a molecular switch to modulate endocytic and autophagy pathways, impacting the source of antigens delivered for MHC class II presentation during cellular stress.
A facile and concise route toward the synthesis of novel imidazo-tetrazolodiazepinones via post-condensation modifications of the Ugi-azide adduct

Abstract This Letter describes novel methodology for the rapid assembly of unprecedented and likely biologically relevant imidazo-tetrazolodiazepinones. The product of a TMSN 3 -Ugi multi-component reaction is treated with an excess of isocyanate to generate 1,5-disubstituted tetrazolo-hydantoins functionalized with an internal-masked amino nucleophile previously introduced by the isocyanide input. Final products are obtained in good overall yields after microwave irradiation of the tetrazolo-hydantoin in acidic media. This methodology allows the production of complex polycyclic compounds in a mere three synthetic steps.
Information systems strategy and end-user application development

End-user computing in organizations with different information systems strategies was studied to determine the nature and characteristics of user-developed applications, systems development practices, quality assurance methods, and policies and procedures for end-user development. The findings showed that the information systems strategies of the firms studied did not markedly affect end-user computing activities. In most of these firms, strategic end-user systems were being designed by functional specialists, suggesting their role as catalysts for introducing strategic uses of information technology in user departments in which computing had been primarily valuable for operational efficiency in the past. Formal systems development practices such as data validation, documentation, and data security were not being followed, indicating a need for user training. Although policies and procedures for hardware and software acquisition were in effect, users were largely unaware of policies or guidelines addressing application development issues.
Agricultural Finance and Credit: The Farm View (Micro)

The financial crisis in agriculture has been a reality for some farm families since early 1980. As with any industry-wide upheaval, it was slow developing. And its origins can be traced back at least a decade. Today we know more about farm financial conditions than at anytime since the crisis began. However, little consensus exists among farmers, policymakers or academics about agriculture's capacity to adjust to financial stress, or the type of public intervention that would be appropriate if existing institutions and markets need to be assisted in making this transition. This paper will be largely descriptive. Hopefully, it will lead to a more fruitful assessment of the policy papers that will be presented later in the conference.
Mining Typical Preferences of Collaborative User Groups

Collaborative filtering systems have the problems of sparsity– providing a recommendation by correlation between only two customers’ preferences, and being unable to recommend a unique item owing to the recommendation based on preference rather than on the content of the item. The native feature space consists of unique words with single dimension when it occurs in documents as items, which can be tens or hundreds of thousands of words for even a moderate-sized text collection. This is prohibitively high for many learning algorithms. Since the feature extraction method using association word mining does not use the profile, it needs not update the profile, and it automatically generates noun phrases by using confidence and support of the Apriori algorithm without calculating the probability for index. However, in case that the feature extraction method is based on a set of association words, it makes an error of judging different documents identically. This paper proposes an association word mining method with weighted word, which reflects not only the preference rating of items but also information on the items. The proposed method is capable of creating the profile of the collaborative users, in which users are grouped according to the vector space model and Kmeans algorithm. Thus, the new method eliminates the existing collaborative filtering system’s problems of sparsity and of recommendations based on the degree of correlation of user preferences. Entropy is used in order to address the said system’s shortcoming whereby items are recommended according to the degree of correlation of the two most similar users within a group. Thus, the typical preference of the group is extracted. Since user preferences cannot be automatically regarded as accurate data, users within the group who have entropies beyond the threshold are selected as typical users. After this selection, the typical preference can be extracted by assigning typical user preferences in the form of weights. By using the typical preference of the group, the method also reduces the time required for retrieving the most similar users within the group.
Structure and Properties of Single Crystalline CaMg2Bi2, EuMg2Bi2, and YbMg2Bi2

Single crystals of CaMg2Bi2, EuMg2Bi2, and YbMg2Bi2 were obtained from a Mg–Bi flux cooled to 650 °C. These materials crystallize in the CaAl2Si2 structure-type (P3m1, No. 164), and crystal structures are reported from refinements of single crystal and powder X-ray diffraction data. EuMg2Bi2 displays an antiferromagnetic transition near 7 K, which is observed via electrical resistivity, magnetization, and specific heat capacity measurements. Magnetization measurements on YbMg2Bi2 reveal a weak diamagnetic moment consistent with divalent Yb. Despite charge-balanced empirical formulas, all three compounds are p-type conductors with Hall carrier concentrations of 2.0(3) × 1019 cm–3 for CaMg2Bi2, 1.7(1) × 1019 cm–3 for EuMg2Bi2, and 4.6(7) × 1019 cm–3 for YbMg2Bi2, which are independent of temperature to 5 K. The electrical resistivity decreases with decreasing temperature and the resistivity ratios ρ(300 K)/ρ(10 K) ≤ 1.6 in all cases, indicating significant defect scattering.
On fluid flow in a heterogeneous medium under nonisothermal conditions

[1] An asymptotic technique, valid in the presence of smoothly varying heterogeneity, provides explicit expressions for the velocity of a propagating pressure and temperature disturbance. The governing equations contain nonlinear terms due to the presence of temperature-dependent coefficients and due to the advection of fluids with differing temperatures. Two cases give well-defined expressions in terms of the parameters of the porous medium: the uncoupled propagation of a pressure disturbance and the propagation of a fully coupled temperature and pressure disturbance. The velocity of the coupled disturbance or front depends upon the medium parameters and upon the change in temperature and pressure across the front. For uncoupled flow, the semianalytic expression for the front velocity reduces to that associated with a linear diffusion equation. A comparison of the asymptotic travel time estimates with calculations from a numerical simulator indicates reasonably good agreement for both uncoupled and coupled disturbances.
Photovoltaic and thermal energy conversion for solar powered satellites

Abstract A systems-oriented technical overview of present candidate solar power satellite baseline concepts is given including preliminary ground rules, assumptions, and specifications used in present system studies. Various critical system elements and required research and development activities are described. Data on expected performance, economics, state of the art, and cost are presented. Present results indicate a potential economic feasibility of solar power satellites by the end of this century.