cssi/SciSciGPT-SciSciNet huggingface dataset:
Effects of camelina meal supplementation on ruminal forage degradability, performance, and physiological responses of beef cattle,,

Three experiments compared ruminal, physiological, and performance responses of beef steers consuming hay ad libitum and receiving grain-based supplements without (control) or with (CAM) the inclusion of camelina meal. In Exp. 1, 9 steers fitted with ruminal cannulas received CAM (2.04 kg of DM/d; n = 5) or control (2.20 kg of DM/d; n = 4). Steers receiving CAM had reduced (P = 0.01) total DMI and tended to have reduced (P = 0.10) forage DMI compared with control. No treatment effects were detected (P ≥ 0.35) for ruminal hay degradability parameters. In Exp. 2, 14 steers fed CAM (1.52 kg of DM/d; n = 7) or control (1.65 kg of DM/d; n = 7) were assigned to a corticotropin-releasing hormone (CRH; 0.1 μg/kg of BW) and a thyrotropin-releasing hormone (TRH; 0.33 μg/kg of BW) challenge. Steers fed CAM had greater (P < 0.05) serum concentrations of PUFA compared with control before challenges. Upon CRH infusion, plasma haptoglobin concentrations tended (P = 0.10) to be reduced and ceruloplasmin concentrations increased at a lesser rate in CAM steers compared with control (treatment × time; P < 0.01). Upon TRH infusion, no treatment effects were detected (P ≥ 0.55) for serum thyrotropin-stimulating hormone, triiodothyronine, and thyroxine. In Exp. 3, 60 steers were allocated to 20 pens. Pens were assigned randomly to receive CAM (2.04 kg of DM/steer daily; n = 10) or control (2.20 kg of DM/steer daily; n = 10) during preconditioning (PC; d -28 to 0). On d 0, steers were transported for 24 h. Upon arrival, pens were assigned randomly to receive CAM or control during feedlot receiving (FR; d 1 to 29). During PC, CAM steers had reduced (P < 0.01) forage and total DMI, and tended to have reduced (P = 0.10) ADG compared with control. Plasma linolenic acid concentrations increased during PC for CAM steers, but not for control (treatment × day; P = 0.02). During FR, steers fed CAM during PC had reduced (P < 0.01) forage and total DMI, but tended (P = 0.10) to have greater G:F compared with control. Steers fed CAM during FR had greater (P < 0.05) plasma concentrations of PUFA, and reduced rectal temperature and concentrations of haptoglobin and ceruloplasmin during FR compared with control. In summary, CAM supplementation to steers impaired forage and total DMI, did not alter thyroid gland function, increased circulating concentrations of PUFA, and lessened the acute-phase protein reaction elicited by neuroendocrine stress responses.
Top-Performance Tokenization and Small-Ruleset Regular Expression Matching: A Quantitative Performance Analysis and Optimization Study on the Cell/B.E. Processor

In the last decade, the volume of unstructured data that Internet and enterprise applications create and consume has been growing at impressive rates. The tools we use to process these data are search engines, business analytics suites, natural-language processors and XML processors. These tools rely on tokenization, a form of regular expression matching aimed at extracting words and keywords in a character stream. The further growth of unstructured data-processing paradigms depends critically on the availability of high-performance tokenizers. Despite the impressive amount of parallelism that the multi-core revolution has made available (in terms of multiple threads and wider SIMD units), most applications employ tokenizers that do not exploit this parallelism. I present a technique to design tokenizers that exploit multiple threads and wide SIMD units to process multiple independent streams of data at a high throughput. The technique benefits indefinitely from any future scaling in the number of threads or SIMD width. I show the approach’s viability by presenting a family of tokenizer kernels optimized for the Cell/B.E. processor that deliver a performance seen, so far, only on dedicated hardware. These kernels deliver a peak throughput of 14.30 Gbps per chip, and a typical throughput of 9.76 Gbps on Wikipedia input. Also, they achieve almost-ideal resource utilization (99.2%). The approach is applicable to any SIMD enabled processor and matches well the trend toward wider SIMD units in contemporary architecture design.
Characterization of native pathogenic antigens of Onchocerca volvulus: identification of high molecular mass protein antigens eliciting interstitial keratitis in a guinea pig model

Sclerosing keratitis is the predominant cause of blindness due to onchocerciasis which is a major human parasitic disease caused by the filarial parasite Onchocerca volvulus. In the present investigation, native pathogenic antigens of O. volvulus which are particularly potent in causing interstitial keratitis were characterized utilizing a guinea pig model. Following demonstration of the protein nature of these antigens using pronase digestion, the crude O. volvulus antigen extract was subjected to stepwise procedures of protein purification. At each stage of purification, pooled antigen fractions were injected into one cornea of presensitized guinea pigs followed by clinical evaluation of stromal inflammation and vascularization at different intervals of time after intrastromal challenge. Initial purification of the pathogenic antigens was carried out in the following order: molecular sieve chromatography on Bio-gel A-5m. anion exchange chromatography on Mono Q followed by DEAE-Sepharose CL-6B and cation exchange chromatography on Mono S. Two out of six different pools from the Mono S column (pool a eluted unbound at 10 mM-NaCl and pool e eluted between 130 mM and 475 mM-NaCl) were found to be most pathogenic. Further purification of Mono S pool a and pool e separately by gel filtration chromatography using Superose 12 demonstrated that the fractions which were most potent in inducing interstitial keratitis contained proteins with approximate molecular masses between 100 and 200 kDa. These results show that minor subfractions of total crude antigens of O. volvulus are largely responsible for induction of experimental interstitial keratitis. We have demonstrated the presence of these antigens in O. volvulus microfilariae by their cross-reactivities with anti-microfilarial antibodies, and hence the relevance of the purified antigens to ocular onchocerciasis in man since sclerosing keratitis is associated with invasion of the cornea by O. volvulus microfilariae. Isolation of these two pathogenic antigen pools represents the practical limits of purification and subsequent animal experiments possible with the available amounts of native parasite material obtained from infected human individuals in the absence of a suitable non-human host or of an in vitro culture system for O. volvulus.
Kinetic Studies on Enzyme-Catalyzed Reactions: Oxidation of Glucose, Decomposition of Hydrogen Peroxide and Their Combination

The kinetics of the glucose oxidase-catalyzed reaction of glucose with O2, which produces gluconic acid and hydrogen peroxide, and the catalase-assisted breakdown of hydrogen peroxide to generate oxygen, have been measured via the rate of O2 depletion or production. The O2 concentrations in air-saturated phosphate-buffered salt solutions were monitored by measuring the decay of phosphorescence from a Pd phosphor in solution; the decay rate was obtained by fitting the tail of the phosphorescence intensity profile to an exponential. For glucose oxidation in the presence of glucose oxidase, the rate constant determined for the rate-limiting step was k = (3.0 ± 0.7) ×104 M−1s−1 at 37°C. For catalase-catalyzed H2O2 breakdown, the reaction order in [H2O2] was somewhat greater than unity at 37°C and well above unity at 25°C, suggesting different temperature dependences of the rate constants for various steps in the reaction. The two reactions were combined in a single experiment: addition of glucose oxidase to glucose-rich cell-free media caused a rapid drop in [O2], and subsequent addition of catalase caused [O2] to rise and then decrease to zero. The best fit of [O2] to a kinetic model is obtained with the rate constants for glucose oxidation and peroxide decomposition equal to 0.116 s−1 and 0.090 s−1 respectively. Cellular respiration in the presence of glucose was found to be three times as rapid as that in glucose-deprived cells. Added NaCN inhibited O2 consumption completely, confirming that oxidation occurred in the cellular mitochondrial respiratory chain.
Evolution of the feeding mechanism in primitive actionopterygian fishes: A functional anatomical analysis of Polypterus, Lepisosteus, and Amia.

The comparative functional anatomy of feeding in Polypterus senegalus, Lepisosteus oculatus, and Amia calva, three primitive actinopterygian fishes, was studied by high-speed cinematography (200 frames per second) synchronized with electromyographic recordings of cranial muscle activity. Several characters of the feeding mechanism have been identified as primitive for actinopterygian fishes: (1) Mandibular depression is mediated by the sternohyoideus muscle via the hyoid apparatus and mandibulohyoid ligament. (2) The obliquus inferioris and sternohyoideus muscles exhibit synchronous activity at the onset of the expansive phase of jaw movement. (3) Activity in the adductor operculi occurs in a double burst pattern—an initial burst at the onset of the expansive phase, followed by a burst after the jaws have closed. (4) A median septum divides the sternohyoideus muscle into right and left halves which are asymmetrically active during chewing and manipulation of prey. (5) Peak hyoid depression occurs only after peak gape has been reached and the hyoid apparatus remains depressed after the jaws have closed. (6) The neurocranium is elevated by the epaxial muscles during the expansive phase. (7) The adductor mandibulae complex is divided into three major sections—an anterior (suborbital) division, a medial division, and a posterolateral division. In Polypterus, the initial strike lasts from 60 to 125 msec, and no temporal overlap in muscle activity occurs between muscles active at the onset of the expansive phase (sternohyoideus, obliquus superioris, epaxial muscles) and the jaw adductors of the compressive phase. In Lepisosteus, the strike is extremely rapid, often occuring in as little as 20 msec. All cranial muscles become active within 10 msec of each other, and there is extensive overlap in muscle activity periods. Two biomechanically independent mechanisms mediate mandibular depression in Amia, and this duality in mouth-opening couplings is a shared feature of the halecostome fishes. Mandibular depression by hyoid retraction, and intermandibular musculature, consisting of an intermandibularis posterior and interhyoideus, are hypothesized to be primitive for the Teleostomi.
Structure of the interstellar boundary explorer ribbon from secondary charge-exchange at the solar-interstellar interface

In 2009, the Interstellar Boundary Explorer discovered a bright "ribbon" of energetic neutral atom (ENA) flux in the energy range ≤0.4–6 keV, encircling a large portion of the sky. This observation was not previously predicted by any models or theories, and since its discovery, it has been the subject of numerous studies of its origin and properties. One of the most studied mechanisms for its creation is the "secondary ENA" process. Here, solar wind ions, neutralized by charge-exchange with interstellar atoms, propagate outside the heliopause; experience two charge-exchange events in the dense outer heliosheath; and then propagate back inside the heliosphere, preferentially in the direction perpendicular to the local interstellar magnetic field. This process has been extensively analyzed using state-of-the-art modeling and simulation techniques, but it has been difficult to visualize. In this Letter, we show the three-dimensional structure of the source of the ribbon, providing a physical picture of the spatial and energy scales over which the secondary ENA process occurs. These results help us understand how the ribbon is generated and further supports a secondary ENA process as the leading ribbon source mechanism.
Spinal Cord Infarction Following Intraaortic Balloon Support

Infarction of the lumbar and sacral spinal cord was demonstrated at autopsy of a 72-year-old man in whom acute paraplegia developed following coronary artery bypass grafting and atrial septal defect repair with intraoperative insertion of an intraaortic balloon. Autopsy findings showed that infarcts of the spinal cord and other key organs were caused by critical occlusion of small arterioles by cholesterol emboli. These emboli apparently arose as a result of the fragmentation of atheromatous plaques within the aorta during use of the intraaortic balloon pump with subsequent embolization and occlusion of small blood vessels.
Structure of tetrahydrobiopterin tunes its electron transfer to the heme-dioxy intermediate in nitric oxide synthase

How 6R-tetrahydrobiopterin (H(4)B) participates in Arg hydroxylation as catalyzed by the nitric oxide synthases (NOSs) is a topic of current interest. Previous work with the oxygenase domain of inducible NOS (iNOSoxy) demonstrated that H(4)B radical formation is kinetically coupled to disappearance of an initial heme-dioxy intermediate and to Arg hydroxylation in a single turnover reaction run at 10 degrees C [Wei, C.-C., Wang, Z.-Q., Wang, Q., Meade, A. L., Hemann, C., Hille, R., and Stuehr, D. J. (2001) J. Biol. Chem. 276, 315-319]. Here we used 5-methyl-H(4)B to investigate how pterin structure influences radical formation and associated catalytic steps. In the presence of Arg, the heme-dioxy intermediate in 5-methyl-H(4)B-bound iNOSoxy reacted at a rate of 35 s(-)(1), which is 3-fold faster than with H(4)B. This was coupled to a faster rate of 5-methyl-H(4)B radical formation (40 vs 12.5 s(-)(1)) and to a faster and more productive Arg hydroxylation. The EPR spectrum of the enzyme-bound 5-methyl-H(4)B radical had different hyperfine structure than the bound H(4)B radical and exhibited a 3-fold longer half-life after its formation. A crystal structure of 5-methyl-H(4)B-bound iNOSoxy revealed that there are minimal changes in conformation of the bound pterin or in its interactions with the protein as compared to H(4)B. Together, we conclude the following: (1) The rate of heme-dioxy reduction is linked to pterin radical formation and is sensitive to pterin structure. (2) Faster heme-dioxy reduction increases the efficiency of Arg hydroxylation but still remains rate limiting for the reaction. (3) The 5-methyl group influences heme-dioxy reduction by altering the electronic properties of the pterin rather than changing protein structure or interactions. (4) Faster electron transfer from 5-methyl-H(4)B may be due to increased radical stability afforded by the N-5 methyl group.
Ferroelectric BiFeO3 X-ray and neutron diffraction study

Abstract Ferroelectric BiFeO 3 is rhombohedral with lattice constants, a H =5·5876, c H =13·867 at room temperature. The space group is R3c with two formula units in the unit cell. The atomic positions have been determined employing both X-ray single crystal and neutron powder diffraction. The oxygen atomic positions could be determined only by neutron diffraction and are interpreted as a rotation of rigid octahedra around the trigonal axis by an angle ω=11°40' from the ideal perovskite positions. The X-ray intensities were visually estimated by the multiple film technique using a Weissenberg camera. The cation positions, refined by least-squares, are in good agreement with those determined from neutron powder diffraction analysis. The final results are given with a reliability factor R =0·02 for neutron powder data and R =0·09 for X-ray single crystal data. With respect to the ideal perovskite structure, the cations are shifted along the trigonal axis in accord with the observed dielectric properties.
The loss in hydrophobic surface area resulting from a Leu to Val mutation at the N‐terminus of the aldehyde dehydrogenase presequence prevents import of the protein into mitochondria

An apparent conservative mutation, Leu to Val, at the second residue of the rat liver mitochondrial aldehyde dehydrogenase (ALDH) presequence resulted in a precursor protein that was not imported into mitochondria. Additional mutants were made to substitute various amino acids with nonpolar side chains for Leu2. The Ile, Phe, and Trp mutants were imported to an extent similar to that of the native precursor, but the Ala mutant was imported only about one-fourth as well. It was shown that the N-terminal methionine was removed from the L2V mutant in a reaction catalyzed by methionine aminopeptidase. The N-terminal methionine of native pALDH and the other mutant presequences was blocked, presumably by acetylation. Because of the difference in co-translational modification, the L2V mutant sustained a significant loss in the available hydrophobic surface of the presequence. Import competence was restored to the L2V mutant when it was translated using a system that did not remove Met1. The removal of an Arg-Gly-Pro helix linker segment (residues 11-14) from the L2V mutant, which shifted three leucine residues toward the N-terminus, also restored import competence. These results lead to the conclusion that a minimum amount of hydrophobic surface area near the N-termini of mitochondrial presequences is an essential property to determine their ability to be imported. As a result, both electrostatic and hydrophobic components must be considered when trying to understand the interactions between precursor proteins and proteins of the mitochondrial import apparatus.
Unreliability of current assays to detect cobalamin deficiency: "Nothing gold can stay"

Comment on Solomon, page [978][1] Measurement of vitamin B12, homocysteine, and methylmalonic acid may not be the ultimate “gold standard” for diagnosis of cobalamin deficiency. Measurement of the serum vitamin B12 level has been widely used as the standard screening test for cobalamin
The critical role of chromosome translocations in human leukemias.

▪ Abstract Many chromosome abnormalities, especially translocations or inversions, are closely associated with a particular morphologic or phenotypic subtype of leukemia, lymphoma, or sarcoma. Cloning the genes at the breakpoints of these rearrangements has had a major impact on our understanding of the molecular biology of cancer. One such gene is MLL (myeloid-lymphoid or mixed lineage leukemia) located at chromosome band 11q23. The target gene(s) of MLL is unknown at present, but because of its homology to the trithorax gene in Drosophila as well as experimental data from mice, it appears to be involved in maintaining the function of some of the homeobox genes. Most genes involved in translocations have homologs in other organisms. Comparison of the functions of these genes in human cells with their function in other systems has enriched our understanding of their role in cell biology.
Natural Antibiotic Resistance of Bacteria Isolated from Larvae of the Oil Fly, Helaeomyia petrolei

Helaeomyia petrolei (oil fly) larvae inhabit the asphalt seeps of Rancho La Brea in Los Angeles, Calif. The culturable microbial gut contents of larvae collected from the viscous oil were recently examined, and the majority (9 of 14) of the strains were identified as Providencia spp. Subsequently, 12 of the bacterial strains isolated were tested for their resistance or sensitivity to 23 commonly used antibiotics. All nine strains classified as Providencia rettgeri exhibited dramatic resistance to tetracycline, vancomycin, bacitracin, erythromycin, novobiocin, polymyxin, colistin, and nitrofurantoin. Eight of nine Providencia strains showed resistance to spectinomycin, six of nine showed resistance to chloramphenicol, and five of nine showed resistance to neomycin. All 12 isolates were sensitive to nalidixic acid, streptomycin, norfloxacin, aztreonam, cipericillin, pipericillin, and cefotaxime, and all but OF008 (Morganella morganii) were sensitive to ampicillin and cefoxitin. The oil fly bacteria were not resistant to multiple antibiotics due to an elevated mutation rate. For each bacterium, the number of resistant mutants per 10(8) cells was determined separately on rifampin, nalidixic acid, and spectinomycin. In each case, the average frequencies of resistant colonies were at least 50-fold lower than those established for known mutator strain ECOR 48. In addition, the oil fly bacteria do not appear to excrete antimicrobial agents. When tested, none of the oil fly bacteria produced detectable zones of inhibition on Pseudomonas aeruginosa, Escherichia coli, Staphylococcus aureus, or Candida albicans cultures. Furthermore, the resistance properties of oil fly bacteria extended to organic solvents as well as antibiotics. When pre-exposed to 20 microg of tetracycline per ml, seven of nine oil fly bacteria tolerated overlays of 100% cyclohexane, six of nine tolerated 10% xylene, benzene, or toluene (10:90 in cyclohexane), and three of nine (OF007, OF010, and OF011) tolerated overlays of 50% xylene-50% cyclohexane. The observed correlation between antibiotic resistance and organic solvent tolerance is likely explained by an active efflux pump that is maintained in oil fly bacteria by the constant selective pressure of La Brea's solvent-rich environment. We suggest that the oil fly bacteria and their genes for solvent tolerance may provide a microbial reservoir of antibiotic resistance genes.
An integrated detection system against false data injection attacks in the Smart Grid

The Smart Grid is a new type of power grid that will use advanced communication network technologies to support more efficient energy transmission and distribution. The grid infrastructure was designed for reliability; but security, especially against cyber threats, is also a critical need. In particular, an adversary can inject false data to disrupt system operation. In this paper, we develop a false data detection system that integrates two techniques that are tailored to the different attack types that we consider. We adopt anomaly-based detection to detect strong attacks that feature the injection of large amounts of spurious measurement data in a very short time. We integrate the anomaly detection mechanism with a watermarking-based detection scheme that prevents more stealthy attacks that involve subtle manipulation of the measurement data. We conduct a theoretical analysis to derive the closed-form formulae for the performance metrics that allow us to investigate the effectiveness of our proposed detection techniques. Our experimental data show that our integrated detection system can accurately detect both strong and stealthy attacks. Copyright © 2014 John Wiley & Sons, Ltd.
Role of adult input in young children's category evolution: II. An experimental study.

Young children's initial categories often are not identical to the adult category labelled by the same word. Eventually, children's categories must evolve to correspond to the adult standard. The purpose of this study was to consider the relative effectiveness of four input strategies in inducing the child to learn the adult-appropriate label and begin to form a new category. Fifty-six children aged 2;0 were taught new labels for objects that they included in categories labelled by different names. Comprehension and production post-tests were then administered. As expected, the most effective strategy involved labelling an object and providing both a physical demonstration and a verbal description of important attributes that made the object a member of the adult-appropriate category. The label plus physical demonstration strategy was next most effective. Neither the label plus verbal description strategy nor the label only strategy was effective for children of this age. Results also indicated that these 24 month olds did not yet honour the convention of mutual exclusivity of basic level categories.
Loss of mitochondrial DNA in the yeast cardiolipin synthase crd1 mutant leads to up-regulation of the protein kinase Swe1p that regulates the G2/M transition.

The anionic phospholipid cardiolipin and its precursor phosphatidylglycerol are synthesized and localized in the mitochondrial inner membrane of eukaryotes. They are required for structural integrity and optimal activities of a large number of mitochondrial proteins and complexes. Previous studies showed that loss of anionic phospholipids leads to cell inviability in the absence of mitochondrial DNA. However, the mechanism linking loss of anionic phospholipids to petite lethality was unclear. To elucidate the mechanism, we constructed a crd1Δrho° mutant, which is viable and mimics phenotypes of pgs1Δ in the petite background. We found that loss of cardiolipin in rho° cells leads to elevated expression of Swe1p, a morphogenesis checkpoint protein. Moreover, the retrograde pathway is activated in crd1Δrho° cells, most likely due to the exacerbation of mitochondrial dysfunction. Interestingly, the expression of SWE1 is dependent on retrograde regulation as elevated expression of SWE1 is suppressed by deletion of RTG2 or RTG3. Taken together, these findings indicate that activation of the retrograde pathway leads to up-regulation of SWE1 in crd1Δrho° cells. These results suggest that anionic phospholipids are required for processes that are essential for normal cell division in rho° cells.
A Branched-Chain Amino Acid-Related Metabolic Signature that Differentiates Obese and Lean Humans and Contributes to Insulin Resistance

Metabolomic profiling of obese versus lean humans reveals a branched-chain amino acid (BCAA)-related metabolite signature that is suggestive of increased catabolism of BCAA and correlated with insulin resistance. To test its impact on metabolic homeostasis, we fed rats on high-fat (HF), HF with supplemented BCAA (HF/BCAA), or standard chow (SC) diets. Despite having reduced food intake and a low rate of weight gain equivalent to the SC group, HF/BCAA rats were as insulin resistant as HF rats. Pair-feeding of HF diet to match the HF/BCAA animals or BCAA addition to SC diet did not cause insulin resistance. Insulin resistance induced by HF/BCAA feeding was accompanied by chronic phosphorylation of mTOR, JNK, and IRS1Ser307 and by accumulation of multiple acylcarnitines in muscle, and it was reversed by the mTOR inhibitor, rapamycin. Our findings show that in the context of a dietary pattern that includes high fat consumption, BCAA contributes to development of obesity-associated insulin resistance.
Optimal Bounds on the Trapping Constant and Permeability of Porous Media

We derive exact expressions for so-called "void" bounds on the trapping constant gamma and fluid permeability k for coated-sphere and coated-cylinder models of porous media. We find that in some cases the bounds are optimal. In these instances, exact expressions are obtained for the relevant length scale that arises in the void bounds, which depends on a two-point correlation function that characterizes the porous medium. This is the first time that model microstructures have been found that exactly realize bounds on either the trapping constant or fluid permeability.
Enhanced prostaglandin synthesis due to phospholipid breakdown in ischemic-reperfused myocardium: Control of its production by a phospholipase inhibitor of free radical scavengers†

The effects of the inhibition of phospholipid degradation and superoxide radical generation on prostaglandin synthesis associated with myocardial ischemia and reperfusion were studied in the isolated, in-situ pig heart model subjected to 60 mins of regional ischemia and a further 60 mins of hypothermic potassium cardioplegic arrest, followed by 60 mins of reperfusion. Myocardial biopsies were taken from the ischemic and non-ischemic regions of the myocardium for measurement of phospholipids, and samples of the perfusate were drawn for estimation of the end-products of arachidonic acid metabolism, 6-keto-prostaglandin-F1 alpha and thromboxane B2. A significant amount of 6-keto-prostaglandin F1 alpha and thromboxane B2 appeared during reperfusion, corresponding with the loss of membrane phospholipids in control animals. Mepacrine, a phospholipase inhibitor, protected the depletion of membrane phospholipids and inhibited the products of arachidonate metabolism. Superoxide dismutase (SOD) and catalase, on the other hand, enhanced the formation of 6-keto-prostaglandin F1 alpha and thromboxane B2. The effects of both mepacrine and the free radical scavengers were pronounced during the reperfusion phase when the most significant depletion in membrane phospholipids occurred. These results suggest that the arachidonate cascade is activated during reperfusion of ischemic myocardium as a consequence of phospholipid breakdown, and this activation can be attenuated by inhibiting phospholipases or enhanced by scavenging oxygen-free radicals generated during reperfusion.
A 1-GHz 6-bit ADC system

A two-rank GaAs sample-and-hold (S/H) chip and four 250-MHz silicon digitizers form a 1-GHz 6-b analog-to-digital converter (ADC) system. The two rank S/H architecture avoids dynamic errors inherent to interleaved ADCs; accuracy exceeds 5.2 effective bits, up to 1-GHz input frequency. Special attention is paid to avoiding GaAs slow transient errors.
Elevated temperature impairs onset of symbiosis and reduces survivorship in larvae of the Hawaiian coral, Fungia scutaria

Many corals obtain their obligate intracellular dinoflagellate symbionts from the environment as larvae or juveniles. The process of symbiont acquisition remains largely unexplored, especially under stress. This study addressed both the ability of Fungia scutaria (Lamarck 1801) larvae to establish symbiosis with Symbiodinium sp. C1f while exposed to elevated temperature and the survivorship of aposymbiotic and newly symbiotic larvae under these conditions. Larvae were exposed to 27, 29, or 31°C for 1 h prior to infection, throughout a 3-h infection period, and up to 72 h following infection. Exposure to elevated temperatures impaired the ability of coral larvae to establish symbiosis and reduced larval survivorship. At 31°C, the presence of symbionts further reduced larval survivorship. As sea surface temperatures rise, coral larvae exposed to elevated temperatures during symbiosis onset will likely be negatively impacted, which in turn could affect the establishment of future generations of corals.
Fidaxomicin for the Treatment of Clostridium difficile Infections

Objective:To evaluate the pharmacology, microbiology, safety, and efficacy of fidaxomicin for treatment of Clostridium difficile infections (CDI).Data Sources:Literature was identified through Ovid MEDLINE (1940-December 2011) and International Pharmaceutical Abstracts (1970-December 2011) using the search terms fidaxomicin, OPT-80, PAR-101, OP-118, difimicin, tiacumicin, lipiarmycin, Clostridium difficile, Clostridium difficile infection, Clostridium difficile-associated diarrhea, and cost. Drug monographs were retrieved from manufacturers’ Web pages, and the Red Book component of Micromedex was used for cost Information.Study Selection and Data Extraction:All pertinent Phase 1,2, and 3 studies published in English were included.Data Synthesis:Fidaxomicin is a macrocyclic compound bactericidal against C. difficile and inhibits toxin and spore production. It has poor oral absorption with high fecal concentrations. Available Phase 2 and 3 data with fidaxomicin 200 mg orally every 12 hours demonstrate simil...
Diffuse Field Decay Rates for Material Characterization

While measurements of internal friction and ultrasonic attenuation have long been known to be sensitive to material damage, applications in materials characterization NDE have been disappointingly few. The usual limitation to testing on specially designed specimens is certainly partly responsible for the lack of field application. Low accuracy in ultrasonic pulse-echo attenuation measurements may be another reason.
A re‐visioning of progressive education

In many ways 1932 was the best year progressive education ever had; at least it was the most hopeful. America, and the world, were in the midst of the Great Depression; capitalism had "failed." Yet the quality that comes through in George Counts' February 1932 speech to the Progressive Education Association-"Dare Progressive Education Be Progressive"-is optimism (Counts, 1969). Counts and many with him firmly believed that the schools could indeed "build a new social order"; a new order less capitalistic, more collectivistic (1969, p. 43), but thoroughly democratic and American. With all the pessimism and despair in the world this was still a time of hope. But the hopes never materialized. Within 10 years of Counts's speech the P.E.A. was a shadow of itself; membership was down about 50 percent, and "the leaders talked incessantly but took few significant actions" (Cremin, 1961, p. 268). The succeeding decade saw the organization and the movement die, with following decades-notably the 1950s-heaping scorn on the movement. It was accused not only of being communist, but of spawning all the ills of American education. Arthur Bestor called progressive education "the great subversion," destroying the prime purpose of education: "deliberate cultivation of the ability to think" (Cremin, 1961, p. 344). Admiral Hyman Rickover had even harsher indictments.
A strain study of the Loudoun Formation, west Maryland, using data restored from boulder to outcrop orientation

The Loudoun Formation of west Maryland consists of conglomerates and phyllites, both of which abound in useful strain and kinematic indicators. Outcrop is sparse, and most of the small-scale structures are seen on the faces of numerous large boulders; thus, strain intensities can be calculated, but stretching and movement directions are scattered. In both the quartzitic and phyllitic members of the formation, cleavage and bedding are clearly decipherable; in outcrop, the dihedral angle between them shows a consistent variation with position along an east-west traverse. We used this angle to assign loose boulders to their correct position in the structural cross section and wrote a computer program to reorient the planes of bedding and cleavage into alignment with those in the chosen outcrop. The rotations necessary to restore data were consistent with structures measured in outcrop in the first place, and they greatly enhance the sparse structural information available from the Loudoun Formation. Our method is applicable to other areas where the intersection of two planar structures provides an internal reference frame for resetting displaced rock.
Menopausal hormone treatment cardiovascular disease: another look at an unresolved conundrum.

Cardiovascular disease (CVD) is the most common cause of death in women. Before the Women's Health Initiative (WHI) hormone trials, evidence favored the concept that menopausal hormone treatment (MHT) protects against CVD. WHI studies failed to demonstrate CVD benefit, with worse net outcomes for MHT versus placebo in the population studied. We review evidence regarding the relationship between MHT and CVD with consideration of mechanisms and risk factors for atherogenesis and cardiac events, results of observational case-control and cohort studies, and outcomes of randomized trials. Estrogen effects on CVD risk factors favor delay or amelioration of atherosclerotic plaque development but may increase risk of acute events when at-risk plaque is present. Long-term observational studies have shown ∼40% reductions in risk of myocardial infarction and all-cause mortality. Analyses of data from randomized control trials other than the WHI show a ∼30% cardioprotective effect in recently menopausal women. Review of the literature as well as WHI data suggests that younger and/or more recently menopausal women may have a better risk-benefit ratio than older or remotely menopausal women and that CVD protection may only occur after >5 years; WHI women averaged 63 years of age (12 years postmenopausal) and few were studied for >6 years. Thus, a beneficial effect of long-term MHT on CVD and mortality is still an open question and is likely to remain controversial for the foreseeable future.
KINETIC PATHWAY IN STRANSKI-KRASTANOV GROWTH OF Ge ON Si(001)

Scanning tunneling microscopy studies of the kinetic processes involved in the two-dimensional (2D) to three-dimensional (3D) transition in Stranski-Krastanov growth of Ge on Si(001) reveal a novel type of 3D cluster that serves as the kinetic pathway for this transition.
Treatment of hidradenitis suppurativa with infliximab in a patient with Crohn's disease.

Background: Hidradenitis suppurativa is a chronic, inflammatory, scarring disease characterized by recurrent flares. Recently, a group of ‘autoinflammatory disorders’ has been described. These disorders are characterized by recurrent inflammatory episodes not mediated by autoantibodies or antigen‐specific T‐cells. Some of these autoinflammatory disorders have been successfully treated with anti‐tumor necrosis factor antibodies.Observations: We describe a patient with hidradenitis suppurativa and a history of inactive Crohn's disease who was treated with infliximab, with subsequent improvement in her skin disease.Conclusions: This case suggests that infliximab may be effective in the treatment of hidradenitis suppurativa in association with Crohn's disease. We also suggest that hidradenitis suppurativa may be closely linked with this new group of autoinflammatory disorders.
Technology and memory: from lifelogging to strategic reminiscence

We now have available huge amounts of data about our personal pasts in the form of photos, social media posts, communications, GPS locations, sensor data and so on. But what can we do with all this data? Is it useful to us or is it a problem? The Lifelogging vision argues that such data promotes 'total recall' addressing problems with everyday forgetting. I first show that Lifelogging doesn't live up to these claims, both overgenerating data and failing to focus on what is important. I then explore other problematic memory situations where people actively want to forget aspects of their past in the context of a relationship breakup, or when they have experienced other negative past events. Drawing on literature from psychological and social theories of memory, I describe how rich personal digital data about a breakup can prevent moving on, and present new designs that help people better deal with data relating to their breakup. Finally I explore new designs for technology mediated reflection; these designs promote demonstrable improvements in psychological well-being by helping us to actively process our pasts to understand our emotional patterns and habits.
Germination behavior of common ragweed (Ambrosia artemisiifolia) populations across a range of salinities

Abstract Common ragweed is a native annual that colonizes disturbed habitats including agricultural fields and roadsides. It is especially abundant along roadways receiving regular applications of deicing salt. Anecdotal evidence has suggested that the emergence of common ragweed seedlings often occurs before the emergence of other roadside species and at salinity concentrations as high as 400 mM L−1, a level that can be found in roadside soils in early spring. However, the extent of this tolerance to salinity in common ragweed populations has not been quantified. The objective of this study was to assess the germination behavior of common ragweed seeds collected from three roadside and two agricultural populations across a salinity gradient. Seed germination of these five populations was monitored daily for 21 d across a sodium chloride gradient [0, 100, 200, 300, and 400 mM L−1] under controlled conditions. Seeds from roadside populations showed consistently greater total germination and rate of germina...
Treatment of neuro-ophthalmic sarcoidosis.

Background Because of the rarity of neuro-ophthalmic sarcoidosis, there are no therapeutic guidelines based on evidence-based medicine for this disorder. Evidence acquisition Review of literature combined with personal experience. Results Corticosteroids are the preferred initial therapy for neuro-ophthalmic sarcoidosis. If patients cannot tolerate the requisite dose of corticosteroid needed to control their disease, or if corticosteroids fail to adequately control the disease process, the choices of a second agent are based on the consideration of rapidity of clinical response and the safety profile. Conclusions Although methotrexate and mycophenolate mofetil are the medications that are often selected after corticosteroid failure, more rapidly acting agents that have been used are infliximab and intravenous cyclophosphamide.
Soil Incorporation of Silica-Rich Rice Husk Decreases Inorganic Arsenic in Rice Grain

Arsenic decreases rice yield, and inorganic grain As threatens human health; thus, strategies to decrease rice As are critically needed. Increased plant-available silica (Si) can decrease rice As, yet the source of Si matters. Rice husk, an underutilized and Si-rich byproduct of rice production that contains less labile C and an order of magnitude less As than rice straw, may be an economically viable Si resource to decrease rice As, yet the impact of rice husk incorporation on As in the rice-soil nexus has not been reported. This proof-of-concept study shows that rice husk incorporation to soil (1% w/w) decreases inorganic grain As by 25-50% without negatively affecting grain Cd, yield, or dissolved CH4 levels. Rice husk is a critical yet perhaps overlooked resource to improve soil quality through enhanced nutrient availability and attenuate human health risks through consumption of As-laden grain.
Morphology measure and 3D reconstruction of corn leaf based on machine vision

A method was proposed to gain the plant configuration information and 3D reconstruction. According to the principles of binocular stereo vision, two images were obtained. By image segmentation technology and edge detection algorithm, leaf edge of each image was extracted. Epipolar line and RGB of color image were applied to match stereo images, then 3D coordinates of the leaf edge were worked out, so the 3D edge of the leaf could be reconstructed. Besides, using the same technique, the surface of the leaf could be reconstructed. According to the point cloud, the distance between any two points could be got. Results of many experiments show that 3D information of corn leaf can easily be reconstructed by this method.
Correlation of Vascular Invasion and Metastasis in Germ Cell Tumors of Testis—A Preliminary Report

A preliminary study was conducted to correlate vascular invasion with metastasis in testicular tumors. A lectin-immunoperoxidase procedure was used to identify the vessels. Together with standard hematoxylin and eosin staining, the presence of tumor cells in vessels was detected. Primary tumor specimens from 37 cases and retroperitoneal lymph nodes from 10 cases of germ cell tumors were studied. The results showed good correlations between vascular invasion in primary tumors and metastasis to lymph nodes in nonseminomatous germ cell tumors, and between vascular invasion in retroperitoneal lymph nodes and the presence of other metastases. Eight of the 9 nonseminomatous germ cell tumor patients with vascular invasion had metastases, and all 4 patients that had vascular invasion in the lymph nodes had other metastases. However, there seemed to be no correlation between vascular invasion and clinical staging in cases with seminoma in which retroperitoneal lymph node dissection was not performed. These observations, although based on a limited number of cases, warrant more extensive investigations.
Attributes, modes, and tenth century potting in north central Kansas

Etude de la dynamique des mutations culturelles et des phases de production a travers la description et l'analyse des ceramiques du Republicain Superieur provenant de 4 sites du centre-nord du Kansas, et de leurs modes de fabrication. Une approche similaire est appliquee a l'etude de la phase ceramique Sylvicole dans la meme region, afin d'identifier les modifications des pratiques ceramiques indiquant une variante ancienne Keith pour la ceramique du Republicain Superieur
Complications of Open Approaches to the Skull Base in the Endoscopic Era.

Objective It is important to characterize the developing complication profile of the open approach as it becomes reserved for more complex disease during the endoscopic era. Our objective was to characterize complication rates of current open skull base surgery. Design Retrospective chart review. Setting Tertiary care center. Participants The study group consisted of 103 patients and 117 open skull base surgeries were performed from 2008 to 2012. Main Outcome Measures Intraoperative/postoperative complications. Methods Fisher exact test and Wilcoxon rank sum test evaluated for associations of complications with potential risk factors. Results Postoperative complications occurred in 53 (45%) cases, of which 36 (31%) were major complications. Malignancy, dural grafting, age, and obesity were not associated with complications. Flap reconstruction was associated with increased complication rates (odds ratio = 2.27; 95% confidence interval: 1.03–5.04). Conclusion The open approach is increasingly utilized for only the most complex lesions, and selection bias cannot be overstated in comparative series. This study suggests that current open complication rates may be above those cited from prior studies, and patient and physician expectations should be adjusted accordingly.
Phase I Trial of Bortezomib in Combination with Rituximab-HyperCVAD/Methotrexate and Cytarabine for Untreated Mantle Cell Lymphoma

Background: Though mantle cell lymphoma (MCL) outcome has improved over the last two decades - especially with dose-intense or high-dose therapy - MCL patients still relapse particularly in >65yo. Bortezomib has shown single agent activity of 33% in relapsed MCL and has been safely combined with conventional as well as intensified doxorubicin-containing regimens, but not with high doses of the methotrexate/cytarabine combination, where there is concern about lung toxicity. Materials and methods: MCL pts from ages 18 through 79, with adequate organ function unless due to lymphoma, and without HIV-1 infection or any significant medical/mental condition were treated under IRB-approved study using R-HCVAD alternating with R-M/A (JCO October 1, 2005) with doxorubicin given by bolus. Bortezomib was added to R-HCVAD as a fixed dose of 1.3 mg/m2 IV given at the end of the first infusion of cyclophosphamide on day 2 and after doxorubicin bolus on day 5. Bortezomib was added to R-M/A after rituximab on day 1 and on day 6, in increasing doses of 0.7, 1, and 1.3 mg/m2 in cohorts of 3 patients. As an additional precaution, the first cohort of patients received a −1 dose level of the cytarabine adjusted by age. Dose limiting toxicity was defined initially as a drop of 10% from baseline in diffusing lung capacity (DLCO) and later increased to 25% (grade 1 toxicity according to National Cancer Institute criteria) after the first cycle of R-MA with bortezomib. Results: Since April 2007, sixteen patients have been entered on the trial, ages 40 to 70 years (median 58). Currently 2/3 patients have been entered in the last cohort. There has been no DLT. After 59 cycles, toxicities according to NCI criteria were as follows: BR-HCVAD Phase I Toxicity in 59 cycles | Variable | Grade1 (%) | Grade2 (%) | Grade3 (%) | Grade4 (%) | |:-------------------------------------------------------------:| ---------- | ---------- | ---------- | ---------- | | *First R-M/A cycle of each patient. 15/16 patients evaluable. | | Thrombocytopenia | 7 (12) | 3 (5) | 8 (14) | 26 (44) | | Neutropenia | 3 (5) | 5 (8) | 4 (7) | 28 (47) | | Anemia | 11 (19) | 23 (39) | 11 (19) | 2 (3) | | Neutropenic fever | | | 5 (8) | 1 (2) | | Dyspnea | | | | | | DLCO* | 2 (3) | | | | | Neurological | 5 (8) | | | | | Sensory | | 1 (2) | | | As expected, responses are excellent with 11 complete responders and 4 partial responders out of 15 evaluable patients, of whom 3 are still on treatment. Conclusion: Bortezomib can be safely combined with R-M/A. Accrual is ongoing and more patients and dose levels will be reported on at the meeting.