cssi/SciSciGPT-SciSciNet huggingface dataset:
Retrofitting rurality: Embodiment and emplacement in disability narratives

Abstract In this paper I examine the ways in which people with physical and sensory disabilities challenge normative (even ableist) constructions of the body-environment dyad. Drawing on insight from eco-phenomenologists and rural scholars, I analyze autobiographical narratives by people with disabilities to illustrate the complex entanglement between embodiment and emplacement. Collectively, these disability life narratives present a series of reconstructive strategies – what I call retrofit tactics – that address some of the commonplaces regarding normative rural embodiment and that make corrective adjustments to rurality (retrofits) to accommodate a wider range of embodied experiences. In the course of the article, I identify four such retrofit strategies, which include (1) expanding conceptions of rural embodiment beyond normative definitions, (2) underscoring the importance of attentiveness to one’s body-in-nature, (3) emphasizing and embracing the interdependency of bodies (rather than an isolationist paradigm), and (4) highlighting the importance of language and narrative in the place-making process, particularly within rural environments that traditionally privilege mobility. I am especially interested in demonstrating how the category of disability both challenges and sharpens our understanding of what it means to inhabit rural places and to move between rural and urban spaces.
Contemplative Science and Secular Ethics

This article argues that the emerging project of contemplative science will be best served if it is informed by two perspectives. First, attention should be paid not only to non-analytical and/or mindfulness-based practices, but to a fuller range of contemplative practices, including analytical styles of meditation. Second, the issue of ethics must be addressed as a framework within which to understand contemplative practice: both theoretically in order to understand better the practices themselves and the traditions they come from, and practically in order to understand the ways in which contemplative practices are deployed in contemporary societies. The Tibetan Buddhist Lojong (blo sbyong) tradition and secularized practices derived from it, which are now an area of study in contemplative science, are examined as a kind of case study in order to make these two points and illustrate their importance and relevance for the future of this emerging field.
Third trimester perinatal mortality associated with immediate delivery versus expectant management according to birthweight category

AbstractObjective: Immediate delivery compared with expectant management in a low risk population stratified by birthweight.Methods: Retrospective cohort of births, stillbirths and neonatal deaths from 2010 through 2012 compiled by the National Center for Health Statistics. Birthweight categories were created using population derived deciles. Gestational age at birth was adjusted to account for time from death to delivery. The risk of immediate delivery was the neonatal death rate. The risk of expectant management was the sum of the conditional stillbirth risk plus the neonatal death rate for the following week. Relative risks were calculated comparing immediate delivery with expectant management by birthweight category.Results: There were 4 966 067 births, 6660 stillbirths and 6979 neonatal deaths. The gestational age at which expectant management exceeded risk of immediate delivery was consistently at or after 39 weeks for all except birthweights above the 95th centile, where the relative risk for death...
Unlinkable complex identity claims

We propose an identity management system allows users to obtain certified identity claims from various identity providers. Those users will be able to use the certified identity claims for authentication and authorization purposes with service providers, with the guarantee of unlinkability of transactions. Furthermore users are able to use identity claims to satisfy complex authentication and authorization policies set by a service provider efficiently with the same level of privacy guarantees. Finally users will be able to mix and match identity attributes from different identity providers in satisfying service provider policies.
From Prediction to Action: A Closed-Loop Approach for Data-Guided Network Resource Allocation

Machine learning methods have been widely used in modeling and predicting network user experience. In this paper, moving beyond user experience prediction, we propose a closed-loop approach that uses data-generated prediction models to explicitly guide resource allocation for user experience improvement. The closed-loop approach leverages and verifies the causal relation that often exists between certain feature values (e.g., bandwidth) and user experience in computer networks. The approach consists of three components: we train a neural network classifier to predict user experience, utilize the trained neural network classifier as the objective function to allocate network resource, and then evaluate user experience with allocated resource to (in)validate and adjust the original model. Specifically, we propose a dual decomposition algorithm to solve the neural network-based resource optimization problem, which is complex and non-convex. We further develop an iterative mechanism for classifier optimization. Numerical results show that the dual algorithm reduces the expected number of unsatisfied users by up to 2x compared with the baseline, and the optimized classifier further improves the performance by 50%.
Susceptibility of U.S. Estuaries to Pollution

Utilizing data primarily from the U.S. Department of Commerce, both estuaries and watersheds for 78 U.S. systems are analyzed. Watersheds are classified according to total population and discrete subpopulations. The Vollenweider approach, which compares hydraulic loading to nutrient loading of lakes, is adapted to estuaries. By considering total population as a surrogate of point source nutrients, agricultural workers as a surrogate of non-point source toxics and nutrients and chemical + metal workers as a surrogate of point source toxics, we can estimate potential anthropogenic impacts on watersheds. When these surrogates are plotted against hydraulic loading, managers have a tool to identify estuaries most likely to be under greatest anthropogenic presaure. The estuaries with highest susceptibility from total population, as well as the estuaries with the the highest susceptibility to toxic stress, are identified. On a Vollenweider diagram, the phosphorous loadings of freshwater bodies are plotted as a function of hydraulic loading. The permissible-excessive phosphorous loadings have been both theoretically and empirically determined. We have replotted the freshwater data and added 33 U.S. estuary P loadings that were previously unavailable. Estuaries plot on the Vollenweider diagram as a continuum of fresh waterbodies, both in terms of hydraulic loading and phosphorus loading. Most estuaries appear to have permissible P loadings. Analysis of nutrient loading (normalized to hydraulic loading) versus water quality parameters like chlorophyll a indicates that estuaries are more efficient users of nutrients than are freshwater bodies, and that they reach a “nutrient saturation point”. Perhaps this is due to grazing or turbidity. It appears that, in general, the OECD eutrophication modeling approach is applicable to estuarine systems as well as lakes and impoundments.
Clinical Significance of the Tumor Suppressor p53 Codon 72 Polymorphic Variants in Multiple Myeloma.

Background: The p53 tumor suppressor gene has a common sequence polymorphism that results in either proline or arginine at amino-acid position 72. The Pro72 and Arg72 variants have been reported to differ in its functional activity. The Arg72 variant induces apoptosis more efficiently than Pro72 variant by its greater ability to localize to the mitochondria and increase the release of cytochrome c into the cytoplasm. In addition, recent studies have demonstrated that Arg72 variant was a better suppressor of cellular transformation, an activity believed to rely on the pro-apoptotic function of p53 . Moreover, the Pro72 variant has been associated with a higher incidence of tumors. Aim: To evaluate the effect of the polymorphic variants of codon 72 and clinical outcome in patients with plasma cell malignancies. Patients and Methods: We analyzed 79 patients with plasma cell malignancies seen at Mayo Clinic between 2000 and 2003. Genomic DNA was extracted from CD138+ sorted plasma cell from bone marrow aspirates. PCR amplification of codon 72 and posterior sequencing was used for the analysis. Results: A total of 79 patients were analyzed. Thirty-four patients (34%) were heterozygous for p53 , 57 (59%) homozygous for Arginine and 6 (6%) homozygous for Proline . The distribution among disorders was as follow, 52 patients had MM, 14 patients with SMM and 13 with MGUS. Among patient with MM 25% were Pro/Arg heterozygous, 71 % were Arg/Arg homozygous and 3.8% Pro/Pro homozygous. Survival data among MM patients and genotype were analyzed to Kaplan- Meier method. No significant differences were found among patients who carried homozygous (72R) or heterozygous genotype and overall survival. We exclude the analysis in MGUS and SMM for a low number of patients available. Conclusions: These findings indicate that codon 72 arginine p53 may not be associated with a prolonged survival in patients with Multiple Myeloma, but further study is needed to assess whether this polymorphism is associated with progression of MGUS to MM, age of onset, clinical manifestations, response to treatment etc.
Changes in total IgE levels predict pulmonary outcome in cystic fibrosis related allergic bronchopulmonary aspergillosis

Background: Allergic bronchopulmonary aspergillosis (ABPA) is a hypersensitivity disorder contributing to lung disease in cystic fibrosis (CF). Although different criteria have been proposed diagnosis of ABPA in clinical practice remains challenging. Objectives: This study analyzed the predictive value of total IgE (t-IgE) levels in a CF cohort alongside with clinical and serologic data. Methods: 387 children and young adults were followed from 2000 to 2006 and retrospectively classified into four groups. Patients showing t-IgE levels below the 95th percentile were categorized as “Aspergillus fumigatus (Af) naive” and “AS sensitized” if specific Af-IgE were present. The term “Former ABPA” was used in patients with elevated t-IgE levels at study entrance, while the “ABPA at risk” group contained patients whose t-IgE values exceeded the 95th percentile during the study period. The t-IgE courses were divided into episodes of change (ΔIgE episodes) and effects of steriod treatment on pulmonary outcome were assessed. Results: 125 (32%) patients were found to be Af naive and 64 (17%) were Af sensitized. 81 ABPA at risk patients (21%) and 116 Former ABPA patients (30%) had elevated t-IgE levels. 874 ΔIgE episodes were identified and accompanied by FEV1 declines (r=-0.21, p Conclusion: In ABPA diagnosis, analyzing the course of t-IgE levels predicts the effect of treatment on pulmonary outcome.
Indices of Water Content in Gaseous Systems, Their Measurement, and Relationship to Each Other

The quantity of water available to microorganisms influences both their growth and death kinetics. The water in microbial cells cannot be measured directly. The equilibrium atmospheric water conditions are usually measured and reported. The attributes of the several measuring units that can be used to indicate the water content in a gaseous atmosphere are described. Equations for their calculation and for converting from the several measurement units described to relative humidity at test temperature are presented.
Seller Beware: How Bundling Affects Valuation

AbstractHow does bundling affect valuation? This research proposes the asymmetry hypothesis in the valuation of bundles: consumers demand more compensation for the loss of items from bundles, compared with the loss of the same items in isolation, yet they express lower willingness to pay for items added to bundles, compared with the same items purchased separately. This asymmetry persists because bundling causes consumers to perceive multiple items as a single, inseparable gestalt unit. Thus, consumers resist altering the “whole” of the bundle by removing or adding items. Six studies demonstrate this asymmetry across judgments of monetary value (Studies 1 and 2) and (dis)satisfaction (Study 3). Moreover, bundle composition—the ability of different items to create the impression of a “whole”—moderates the effect of bundling on valuation (Study 4), and the need to replace missing items (i.e., restoring the “whole”) mediates the effect of bundling on compensation demanded for losses (Study 5). Finally, the a...
Anglophone cookbooks and the making of the Mediterranean

ABSTRACTThe Anglophone cookbook writers Elizabeth David, Claudia Roden, and Paula Wolfert situate Mediterranean cookery at the intersection of science, history, literature, and art. In conversation with one another they build a discourse of Mediterranean food that binds up cooking and eating with cultural identity. To establish their authority as experts over the wide and varied Mediterranean zone, David, Roden, and Wolfert reach for an elusive unity across the sea, presupposing not only a shared history but an imagined past in which the Mediterranean presented a single cuisine and, by extension, a single culture. In suggesting the possibility of eating one's way into knowledge of a culture, each author stresses her own deep ties to the Mediterranean, sidestepping the fundamental ambiguity of these links. The Mediterranean their writing creates echoes this ambiguity, its lacunae bringing into relief the constructed nature of the “Mediterranean diet” and the unified Mediterranean it imagines. This construc...
A cooperative algorithm for determining surface orientation from a single view

This paper addresses the problem of determining local surface orientation from the intensity information contained in a single monocular view. It represents another look at the problem of obtaining shape from shading information. This problem was first formulated by as the solution of first-order non-linear partial differential equations. It was subsequently reformulated by to take advantage of the geometric insight provided by the gradient space approach popularized by and .
Broadband Electromechanical Spectroscopy: characterizing the dynamic mechanical response of viscoelastic materials under temperature and electric field control in a vacuum environment

The viscoelasticity of a variety of active materials is controllable, e.g., by the application of electric or thermal fields. However, their viscoelastic behavior cannot be fully explored by current methods due to limitations in their control of mechanical, electrical, and thermal fields simultaneously. To close this gap, we introduce Broadband Electromechanical Spectroscopy (BES). For the specific apparatus developed, specimens are subjected to bending and torsional moments with frequencies up to 4 kHz and amplitudes up to 10−4 Nm (the method is sufficiently general to allow for higher and wider frequency ranges). Deflection/twist is measured and moments are applied in a contactless fashion to minimize the influence of the apparatus compliance and of spurious damping. Electric fields are applied to specimens via surface electrodes at frequencies up to 10 Hz and amplitudes up to 5 MV/m. Experiments are performed under vacuum to remove noise from the surrounding air. Using BES, the dynamic stiffness and damping in bending and torsion of a ferroelectric ceramic, lead zirconate titanate, were measured at room temperature, while applying large, cyclic electric fields to induce domain switching. Results reveal large increases of the specimen’s damping capacity and softening of the modulus during domain switching. The effect occurs over wide ranges of mechanical frequencies and permits lowering of the resonance frequencies. This promises potential for using ferroelectrics for active vibration control beyond linear piezoelectricity. More generally, BES helps improve current understanding of microstructure kinetics (such as during domain switching) and how it relates to the macroscopic viscoelastic response of materials.
Data Science Education: We're Missing the Boat, Again

In the first wave of data science education programs, data engineering topics (systems, scalable algorithms, data management, integration) tended to be de-emphasized in favor of machine learning and statistical modeling. The anecdotal evidence suggests this was a mistake: data scientists report spending most of their time grappling with data far upstream of modeling activities. A second wave of data science education is emerging, one with increased emphasis on practical issues in ethics, legal compliance, scientific reproducibility, data quality, and algorithmic bias. The data engineering community has a second chance to influence these programs beyond just providing a set of tools. In this panel, we'll discuss the role of data engineering in data science education programs, and how best to capitalize on emerging opportunities in this space.
The Construction of Judean Diasporic Identity in Ezra–Nehemiah

This essay explores how Ezra–Nehemiah partially inverts the traditional paradigm of exile found in other biblical writings. When one community is formed at some distance from another in antiquity, the derivative community normally appears as a dependent community (or colony). Yet, in Ezra–Nehemiah the homeland repeatedly experiences renewal through initiatives undertaken by diaspora Judeans. Particular attention is given to how the vertical alliances forged within the Achaemenid administration by two diaspora leaders—Ezra and Nehemiah—are deployed to benefit Yehud. The commendation of Ezra and Nehemiah raises fascinating issues about developing notions of Judean ethnicity and identity in a world dominated by imperial interests.
Integrated dielectrophoretic and surface plasmonic platform for million-fold improvement in the detection of fluorescent events

We present an integrated dielectrophoretic (DEP) and surface plasmonic technique to quantify ∼1 pM of fluorescent molecules in low conductivity buffers. We have established a DEP force on target molecules to bring those molecules and place them on the nanometallic structures (hotspots) for quantification through surface plasmonic effects. Our results show that the DEP is capable of placing the fluorescent molecules on the hotspots, which are depicted as a significant reduction in the fluorescence lifetime of those molecules. To efficiently integrate the DEP and plasmonic effects, we have designed and utilized pearl-shaped interdigitated electrodes (PIDEs) in experiments. These electrodes generate 2-3 times higher DEP force than traditional interdigitated electrodes. Therefore, high-throughput assays can be developed. The nanometallic structures were strategically fabricated in the periphery of PIDEs for smooth integration of DEP and plasmonic detection. With the introduction of DEP, about 106-fold improvement was achieved over existing plasmonic-based detection. Therefore, this simple addition to the existing surface plasmonic-based detection will enable the disease related protein detection.
Wəlastəkwey (Maliseet) Homeland: Waterscapes and Continuity within the Lower St. John River Valley, 1784-1900

After decades of intense immigration to the lower St. John River Valley, the Maliseets, the Indigenous people of this watershed, struggled to inhabit the southern portion of their homeland. The Maliseets, though, successfully retained their cultural attachment to the lower river, the lakes, and the coast through birchbark technology and fishing. Their historical memory also provided alternative narratives to dispossession and conveyed a waterscape where Indigenous lifestyles coexisted with societies in New Brunswick. And while some Maliseet families chose to live beyond their reserve villages, Indigenous leaders secured two small reserves at The Brothers (Kennebecasis Bay) and Oromocto.
Limiting Standards of Bacterial Quality for Sources of Purified Water Supplies

The growing difficulties experienced in obtaining purified water supplies of safe and palatable quality from sources highly polluted by sewage and industrial wastes have made apparent the need of applying some rational standard whereby excessive pollution of these sources can be brought under some definite and economical control. In several states, a tentative standard of this kind has been adopted, based on the results of a comprehensive study of the limitations of current water purification processes made a few years ago by the U. S. Public Health Service in connection with its investigations of stream pollution. Although the results of this study have been fully published elsewhere, it has seemed desirable to undertake in this paper an interpretation of them with particular reference to the formulation of a working standard such as above indicated and to illustrate its application in one or two specific cases. In connection with the Public Health Service's study, three major series of observations were made. The first consisted of a detailed collective survey of the performance of 17 representative municipal water purification plants located on the Ohio and several other rivers; the second, of a similar survey of 14 plants located along the Great Lakes; and the third, of a long series of observations, aggregating some five years in time, at a large-scale experimental water filtration plant located on the Ohio River at Cincinnati. Although the combined data of this study embraced almost every conceivable combination of water treatment, ranging from simple chlorination to highly elaborated filtration, with double-stage coagulation, sedimentation and chlorination, the process most frequently observed was ordinary rapid-sand filtration, aided by post-chlorination. As this particular combination of treatment appears to represent the normal type used most widely throughout the United States, its performance represents probably the most reasonable basis of any general requirements which might be adopted for limiting raw water pollution.
Musical Interests and Abilities in Individuals with Developmental Disabilities

Abstract This chapter reviews studies of musicality in individuals with Williams syndrome, Down syndrome, and autism spectrum disorders. Music can be used to assess a wide range of perceptual, cognitive, motor, and affective processes. We discuss how the study of musicality contributes to our understanding of each of these syndromes, drawing connections to the underling neurobiology when possible. After consideration of the methodological limitations of previous studies, we make suggestions for future areas of research within this field. Research into musicality in these developmental disorders can contribute to overarching questions about music, including domain general versus domain-specific mechanisms, development of musical interest and skill, and musical enculturation. Implications for understanding both typical and atypical development are discussed.
On-Chip Hybrid Photonic-Plasmonic Waveguides with Ultrathin Titanium Nitride Films

A solid-state hybrid photonic–plasmonic (HPP) waveguide geometry has been experimentally demonstrated with plasmonic titanium nitride. The configuration is made with robust fabrication techniques, ...
Electronic structures and spectroscopic signatures of silicon-vacancy containing nanodiamonds

The presence of midgap states introduced by localized defects in wide-band-gap-doped semiconductors can strongly affect the electronic structure and optical properties of materials, generating a wide range of applications. Silicon-divacancy defects in diamond have been recently proposed for probing high-resolution pressure changes and performing quantum cryptography, making them good candidates to substitute for the more common nitrogen-vacancy centers. Using group-theory and ab initio electronic structure methods, the molecular origin of midgap states, zero-phonon line splitting, and size dependence of the electronic transitions involving the silicon-vacancy center is investigated in this paper. The effects of localized defects on the Raman vibrational and carbon $K$-edge x-ray absorption spectra are also explored for nanodiamonds. This paper presents an important analysis of the electronic and vibrational structures of nanosized semiconductors in the presence of midgap states due to localized defects, providing insight into possible mechanisms for modulating their optical properties.
Hourly rainfall climatology of Louisiana

This study introduces a climatology of hourly precipitation for four first-order weather stations across Louisiana, investigates possible changes in the hourly precipitation distribution, and links winter (DJF) Gulf of Mexico (GOM) sea surface temperatures (SST) to the frequency of hours with precipitation. Results indicate that it precipitates between 431 and 457 h annually, equivalent to roughly 5% of the total annual hours, with distinct seasonal differences. For example, the duration of events is much longer in winter compared to summer, while the number of rainfall events is greater in summer. Using regression techniques, three of the four stations showed a statistically significant increase in 90th percentile hourly events and hourly intensity. At the same time, the frequency of light hourly events (0.254 mm, 1.27 mm, 2.54 mm) decreased. It was also determined that winter GOM SST significantly correlated with the number of hours with precipitation across coastal Louisiana, possibly related to the frequency of synoptic types such as frontal overrunning.
LDM and SHVC Mobile TV Coverage Spillover Into Fixed Rooftop Reception and MVPD Retransmission Consent in the U.S.

By jointly using layered division multiplexing (LDM) and scalable hierarchical video coding (SHVC), ATSC 3.0 will be used to deliver service targeted to both mobile and traditional rooftop antenna receivers. Under this approach, a physical layer pipe (PLP) with robust coded modulation will ensure mobile reception in an area comparable to an ATSC 1.0 TV station’s current 15 dB rooftop coverage. However, the same approach will also give rise to increased coverage overlap between TV stations, as the same robust PLP will be decoded by rooftop receivers over a much larger area beyond ATSC 1.0’s 15 dB contours. When multiple independently owned TV stations affiliated to the same broadcast programming network overlap the subscriber footprint of a multichannel video program distributor (MVPD) they risk becoming redundant affiliates so the MVPD could pit them against each other in bargaining over lower retransmission consent fees. We calculate the potential increase in rooftop coverage overlap among same-network affiliates of the four largest U.S. over-the-air broadcast programming networks in the U.S. (ABC, CBS, NBC, and Fox). We find that as much as 75% of the population will have access to at least one redundant network affiliate, and 60% will have access to two affiliates or more. Under U.S. federal communications commission (FCC) rules, MVPDs can only pit affiliates against each other if the out-of-market TV station is classified by the FCC as significantly viewed (SV) on a per-county basis. Thus, we analyze if an increase in coverage overlap would in fact increase the number of counties where out-of-market stations become SV. We build a predictive random forests model based on current ATSC 1.0 15 dB coverage and the publicly available list of existing SV stations. With an LDM upper layer with a reception threshold of 2 dB —equivalent in bitrate to one full-HD 1080p program—, the model predicts that the number of county/SV station pairs would increase by 100% or more. This suggest that despite all the benefits of the LDM + SHVC approach, and the potential to increase revenues through service to mobile consumers, there is a risk that this approach may negatively affect TV broadcasters’ retransmission consent revenues. We discuss a number of potential trade-offs and solutions that can help to mitigate this issue.
More than just a powerhouse.

Three genomes must cooperate in plants — those in the nucleus, mitochondria and chloroplasts. Biparental inheritance of the nucleus and maternal inheritance of the organelles has made studying these interactions difficult. A new method allows the nucleus to be inherited paternally so the ‘black box’ of interactions can be studied.
An Annotated Bibliography of Key Studies in Medical Education in 2019: Applying the Current Literature to Educational Practice and Scholarship.

Pediatric educators desire to and should strive to incorporate current educational methods and ideas into their professional practices. The overwhelming volume of medical education literature makes this difficult. This article provides an overview of 18 key articles from the 2018 literature that the authors considered impactful for the field of pediatric medical education. The author group has extensive combined leadership experience and expertise across the continuum of pediatric medical education and used an iterative, staged process to review 2270 abstracts from 13 medical education-related journals. This process aimed to identify a subset of articles that were most relevant to educational practice and scholarship and most applicable to pediatric medical education. Author pairs independently reviewed and scored abstracts and reached consensus to identify the abstracts that best met these criteria. Selected abstracts were discussed using different author pairs to determine the final articles included in this review. The 18 articles selected are summarized. The results showed a cluster of studies related to assessment, learner education and teaching, communication, and culture and climate. This review offers a summary for educators interested in remaining knowledgeable and current regarding the most relevant and valuable information in the field of medical education.
Modeling and Optimization of a Longitudinally-Distributed Global Solar Grid

Our simulation-based experiments are aimed to demonstrate a use case on the feasibility of fulfillment of global energy demand by primarily relying on solar energy through the integration of a longitudinally-distributed grid. These experiments demonstrate the availability of simulation technologies, good approximation models of grid components, and data for simulation. We also experimented with integrating different tools to create realistic simulations as we are currently developing a detailed tool- chain for experimentation. These experiments consist of a network of model houses at different locations in the world, each producing and consuming only solar energy. The model includes houses, various appliances, appliance usage schedules, regional weather information, floor area, HVAC systems, population, number of houses in the region, and other parameters to imitate a real-world scenario. Data gathered from the power system simulation is used to develop optimization models to find the optimal solar panel area required at the different locations to satisfy energy demands in different scenarios.
Imaging Data on Characterization of Retinal Autofluorescent Lesions in a Mouse Model of Juvenile Neuronal Ceroid Lipofuscinosis (CLN3 Disease)

Abstract Juvenile neuronal ceroid lipofuscinosis (JNCL, aka. juvenile Batten disease or CLN3 disease), a lethal pediatric neurodegenerative disease without cure, often presents with vision impairment and characteristic ophthalmoscopic features including focal areas of hyper-autofluorescence. In the associated research article “Loss of CLN3, the gene mutated in juvenile neuronal ceroid lipofuscinosis, leads to metabolic impairment and autophagy induction in retinal pigment epithelium” (Zhong et al., 2020) [1] , we reported ophthalmoscopic observations of focal autofluorescent lesions or puncta in the Cln3Δex7/8 mouse retina at as young as 8 month old. In this data article, we performed differential interference contrast and confocal imaging analyses in all retinal layers to localize and characterize these autofluorescent lesions, including their spectral characteristics and morphology. We further studied colocalization of these autofluorescent lesions with the JNCL marker mitochondrial ATP synthase F0 sub-complex subunit C and various established retinal cell type markers.
Adaptive Shot Technology To Address Severe Lithography Challenges For Advanced FOPLP

Fan-out wafer level packaging (FOWLP) is a popular new packaging technology that allows the user to increase I/O in a smaller IC size than fan-in wafer level packaging. Market drivers such as 5G, IoT, mobile and AI will all use this technology. According to Yole Developpement’s analysis, the fan-out packaging market size will increase to $3 billion in 2022 from $2.44 hundred million in 2014, validating the market requirement for fan out packaging. While FOWLP has been used for many years, there is still a relentless drive to reduce the cost, and fan-out panel level packaging (FOPLP) has been proposed as one possible solution. FOPLP allows users to put more chips on a substrate, meaning more product output and a higher substrate utilization percentage. According to Yole’s analysis, the FOPLP market size will increase to $2.79 hundred million with 79% CAGR, showing that more people are adopting FOPLP.FOPLP has many advantages and low cost potential, but it faces significant process challenges, such as die placement error and substrate warpage control. One of the key challenges is the trade-off between overlay, yield, and throughput during the lithography processing steps. A user exposes multiple dies per exposure shot to increase throughput, but this can result in lower overlay yield because of "pick and place" die placement error. To overcome the low yield issue, each die needs to be aligned, but this impacts throughput, so a compromise is required. To find the balance point between throughput and overlay is one of the biggest challenges for FOPLP.In this paper we address the tradeoff between throughputs and overlay yield, we demonstrate an integrated feedforward adaptive shot solution. This feedforward approach uses a third party metrology system to measure reconstituted panel die location data and sends the data to the stepper via a network. With feedforward algorithm technology, the stepper uses smart adaptive shot technology to generate an optimized variable shot size layout. This layout ensures the overlay yield is within specification with the minimum number of exposure steps. With feedforward adaptive shot technology, the user can maximize the throughput of the stepper and ensure the overlay yield at the same time.
Risk factors for steroid-induced affective disorder in children with leukemia.

Corticosteroids are essential to treating childhood acute lymphoblastic leukemia (ALL), and can cause significant neuropsychiatric side effects. This retrospective chart review is a preliminary exploration of characteristics associated with psychiatry consultation and steroid-induced affective disorder (SIAD) during ALL treatment. Of 125 ALL patients (ages 1-10 years), 56 (44.8%) received psychiatry consultation. Thirty-nine (31.2%) of the total cohort were diagnosed with SIAD. SIAD was significantly associated with family psychiatric history, but not with steroid exposure, CNS radiation, sociodemographic factors, developmental delay, Trisomy 21, or prior psychiatric history. Gathering family psychiatric history may help identify children at increased risk of SIAD.
Emerging monitoring technologies in kidney transplantation

Non-invasive technologies to monitor kidney allograft health utilizing high-throughput assays of blood and urine specimens are emerging out of the research realm and slowly becoming part of everyday clinical practice. HLA epitope analysis and eplet mismatch score determination promise a more refined approach to the pre-transplant recipient-donor HLA matching that may lead to reduced rejection risk. High-resolution HLA typing and multiplex single antigen bead assays are identifying potential new offending HLA antibody subtypes. There is increasing recognition of the deleterious role non-HLA antibodies play in post-transplant outcomes. Donor-derived cell-free DNA detected by next-generation sequencing is a promising biomarker for kidney transplant rejection. Multi-omics techniques are shedding light on discrete genomic, transcriptomic, proteomic, and metabolomic signatures that correlate with and predict allograft outcomes. Over the next decade, a comprehensive approach to optimize kidney matching and monitor transplant recipients for acute and chronic graft dysfunction will likely involve a combination of those emerging technologies summarized in this review.
The Cambridge Companion to British Romanticism and Religion

The Cambridge Companion to British Romanticism and Religion provides the first scholarly survey of the connections between literature, religion, and intellectual life during the British Romantic period (1780s–1832). Part I, 'Historical Developments,' examines diverse religious communities, texts, and figures that shaped British Romantic culture, investigating the influence of Christianity, Judaism, Islam, Hinduism, and atheism on the literature of the times. Part II, 'Literary Forms,' considers British Romanticism and religion through attention to major genres such as poetry, the novel, drama, sermons and lectures, and life writing. Part III, 'Disciplinary Connections,' explores links between religion, literature, and other areas of intellectual life during the period, including philosophy, science, politics, music, and painting.
Shift Work Adaptation Among Police Officers: The BCOPS Study.

Few studies have examined shiftwork adaptation among police officers or potential differences in disease biomarkers among adapted and maladapted shiftworkers. This study characterized shiftwork ada...
Amazon's HQ2 in Arlington: New Digs, New Strategy?

When Brian Huseman, vice president of public policy for the Seattle-based internet retailer and technology company Amazon.com (Amazon), prepared to meet economic-development officials and community leaders from Arlington, Virginia, in the wake of the company's February 2019 decision to pull a second headquarters location out of New York City, a lot was on the line. Facing a limit on its growth in Seattle, Amazon had embarked on a search for a second corporate headquarters, dubbed HQ2, in September 2017, and ultimately surprised the country when it announced its decision to split its HQ2 into two locations, Arlington and New York City, in late 2018. New York ultimately failed to give Amazon the warm welcome it was looking for, so Amazon focused solely on Arlington to claim the biggest economic development prize in recent memory. Amazon was making a huge commitment to Arlington including plans to develop up to eight million square feet of office space and hire 25,000 employees (each with an average salary higher than $100,000) over the next 15 years one that would make it the region's largest private-sector employer. Huseman wanted to be sure Virginia was fully prepared to create the right ecosystem for Amazon's HQ2 to thrive. How should the e-retail giant approach the meeting, considering what could be asked of itand what it should request in return? Excerpt UVA-S-0323 Rev. Feb. 8, 2021 Amazon's HQ2 in Arlington: New Digs, New Strategy? When Brian Huseman, vice president of public policy for the Seattle-based internet retailer and technology company Amazon.com (Amazon), prepared to meet economic-development officials and community leaders from Arlington, Virginia, in the wake of the company's February 2019 decision to pull a second headquarters location out of New York City, a lot was on the line. Facing a limit on its growth in Seattle, Amazon had embarked on a search for a second corporate headquarters, dubbed HQ2, in September 2017, and ultimately surprised the country when it announced its decision to split its HQ2 into two locations, Arlington and New York City, in late 2018. Despite the wider talent-pool advantages that came with having headquarters in both locations, New York ultimately failed to give Amazon the warm welcome it was looking for, forcing Amazon to halt its plans in New York and focus solely on Arlington to claim the biggest economic development prize in recent memory. Amazon was making a huge commitment to Arlington including plans to develop up to eight million square feet of office space and hire 25,000 employees (each with an average salary higher than $ 100,000) over the next 15yearsone that would make it the region's largest private-sector employer. Huseman wanted to be sure Virginia was fully prepared to create the right ecosystem for Amazon's HQ2 to thrive. How should the e-retail giant approach the meeting, considering what could be asked of itand what it should request in return? . . .
Interventionist counterfactuals and the nearness of worlds

A number of authors have recently used causal models to develop a promising semantics for non-backtracking counterfactuals. Briggs (Philosophical Studies 160:39–166, 2012) shows that when this semantics is naturally extended to accommodate right-nested counterfactuals, it invalidates modus ponens, and therefore violates weak centering given the standard Lewis/Stalnaker interpretation of the counterfactual in terms of nearness or similarity of worlds. In this paper, I explore the possibility of abandoning the Lewis/Stalnaker interpretation for some alternative that is better suited to accommodate the causal modeling (CM) semantics. I argue that a revision of McGee’s (The Journal of Philosophy 82:462–471, 1985) semantics can accommodate CM semantics without sacrificing weak centering, and that CM semantics can therefore be situated within a general semantics for counterfactuals that is based on the nearness or similarity of worlds.
Connectome-wide Functional Connectivity Abnormalities in Youth With Obsessive-Compulsive Symptoms.

Abstract Background Obsessive compulsive symptomatology (OCS) is common in adolescence but usually does not meet the diagnostic threshold for obsessive compulsive disorder. Nevertheless, both OCD and subthreshold OCS are associated with increased likelihood of experiencing other serious psychiatric conditions including depression and suicidal ideation. Unfortunately, there is limited information on the neurobiology of OCS. Methods Here we undertook one of the first brain imaging studies of OCS in a large adolescent sample (analyzed n=832) from the Philadelphia Neurodevelopmental Cohort. We investigated resting-state fMRI functional connectivity using complementary analytic approaches that focus on different neuroanatomical scales, from known functional systems to connectome-wide tests. Results We found a robust pattern of connectome-wide, OCS-related differences, as well as evidence of specific abnormalities involving known functional systems, including dorsal and ventral attention, frontoparietal and default mode systems. Analysis of cerebral perfusion imaging and high resolution structural imaging did not show OCS-related differences, consistent with domain specificity to functional connectivity. Conclusions The brain connectomic associations with OCS reported here, together with early studies of its clinical relevance, support the potential for OCS as an early marker of psychiatric risk that may enhance our understanding of mechanisms underlying the onset of adolescent psychopathology.
Different evolutionary pathways lead to incomplete convergence of elongate body shapes in carnivoran mammals.

Although convergence is often recognized as a ubiquitous feature across the Tree of Life, whether the underlying traits also exhibit similar evolutionary pathways towards convergent forms puzzles biologists. In carnivoran mammals, "elongate," "slender," and "long" are often used to describe and even to categorize mustelids (martens, polecats, and weasels), herpestids (mongooses), viverrids (civets and genets), and other carnivorans together. But just how similar these carnivorans are and whether there is convergence in the morphological component that contribute to elongation has never been assessed. Here, I found that these qualitatively-described elongate carnivorans exhibited incomplete convergence towards elongate bodies compared to other terrestrial carnivorans. In contrast, the morphological components underlying body shape variation do not exhibit convergence despite evidence that these components are more elongate in elongate carnivorans compared to non-elongate carnivorans. Furthermore, these components also exhibited shorter but different phylogenetic half-lives towards more elongate adaptive peaks, indicating that different selective pressures can create multiple pathways to elongation. Incorporating the fossil record will facilitate further investigation of whether body elongation evolved adaptively or if it is simply a retained ancestral trait.
Water Consumption in the Lower Colorado River Valley

The average annual water consumption in the lower Colorado River valley between Davis Dam and Imperial Dam during the period 1950-1966 is about 1,200,000 acre-feet, the average of values computed by an (1) inflow-outflow budget, and (2) consumptive-use coefficients applied to acreages. Estimates of water consumption computed by each of the methods differ by as much as 115,000 acre-feet for some reaches. These differences are not considered unreasonable in view of the large flows of the Colorado River relative to the water consumed and the uncertainties of many of the values of individual items of the two methods.
An antibody-induced enhancement of the transducin-stimulated cyclic GMP phosphodiesterase activity.

In this work we have characterized the ability of a carboxyl peptide-specific antibody (AS/7), raised against the α subunit of transducin (αT), to potentiate the stimulation of the cyclic GMP phosphodiesterase (PDE) by transducin. The complexation of the purified guanosine 5′-O-(3-thiotriphosphate) (GTP γS)-bound form of α T (α T.GTP γ S) with AS/7 results in a 2-5-fold enhancement in the total levels of cyclic GMP hydrolysis measured after 1 min. This potentiation by AS/7 cannot be attributed simply to an increase in the apparent affinity of αT. GTP γS for the effector enzyme, nor to an increased affinity of the enzyme for the substrate cyclic GMP. The AS/7-induced potentiation is specific for α T.GTP γS-PDE interactions; this antibody has no effect on the activity of the trypsin-activated PDE nor on the ability of the GDP-bound form of αT to inhibit the trypsin-activated enzyme (Kroll, S., Phillips, W. J., and Cerione, R. A. (1989) J. Biol. Chem. 264, 4490-4497). Phosphatidylcholine vesicles also will enhance the α T.GTP γ S-stimulated PDE activity (1.5-2-fold) relative to that measured in the absence of a lipid milieu. However, the potentiations of α T-stimulated cyclic GMP hydrolysis elicited by AS/7 and lipids represent separate events. Titration profiles describing the AS/7-induced potentiation, as a function of the amount of antibody added to the assay mixtures, indicate that maximal activity occurs when there is one molecule of AS/7 per two molecules of αT.GTP γ S; the AS/7-induced potentiation is lost when AS/7 much greater than αT. GTP γ S, i.e. conditions which favor the formation of monovalent AS/7-αT.GTP γ S complexes. When the AS/7 is papain-treated to yield monovalent antibody molecules, complexation between these monovalent antibodies and αT still occurs (as reflected by the ability of these antibodies to block rhodopsin-αT coupling); however, the potentiation of the αT.GTP γS-stimulated PDE activity is lost. Taken together, these results suggest that the AS/7-induced potentiation of αT-stimulated activity is dependent on the bivalent nature of the antibody, and maximal stimulation of PDE activity is achieved by the interactions of two activated-αT molecules with a single molecule of PDE.