cssi/SciSciGPT-SciSciNet huggingface dataset:
Anxiety, Productivity, Performance, and Culture in the Rorschachs of a Multiethnic Group of Adolescents

L’article que nous presentons rapporte une recherche qui a pris en compte les aspects ethnique, culturel et de personnalite dans la productivite et la performance liees aux niveaux d’anxiete et de controle rationnel chez des adolescents de differentes origines ethniques dans le sud du Bresil. Cette recherche s’enracine dans un projet que nous menons depuis 1988 portant sur l’etude des capacites de productivite. Nous cherchions alors a determiner si le niveau d’anxiete situationnelle etait different chez les indiens Tukuna et chez les blancs non-Tukuna d’origine portugaise vivant dans l’etat d’Amazonie du Nord du Bresil. Nous avons pu montrer que les indiens Tukuna et les sujets non-Tukuna sont similaires quant a leurs besoins de reussite et de production et a leur haut niveau de besoin d’affiliation (recherche de protection). Dans l’etude presente, le Rorschach dans la perspective de Klopfer fut propose a 107 adolescents des deux sexes d’origine portugaise, afro-bresilienne, allemande, israelite et italie...
The role of amniotomy in induction of labour with oral administration of prostaglandin E2

SummaryProstaglandin E2 was administered orally in doses of 0.5 mg. to 2.0 mg. every 2 hours to 169 women for induction of labour. Induction was successful in 153 women (90%). In 99 of these women, low amniotomy was performed at the beginning. Performance of amniotomy at the beginning of induction did not alter the incidence of successful induction but did lead to a mean induction-delivery interval shorter than that in women who had amniotomy performed in the active phase of labour. Vomiting and/or diarrhoea occurred in 34 women (20 %). Uterine hypertonus of only transient nature occurred in 3 women. One woman suffered from atonic post-partum haemorrhage. No adverse effects on the fetus were apparent. The presence of fetopelvic disproportion was associated with a slow rate of cervical dilatation and unsuccessful induction.
Inheritance and biochemical analysis of four electrophoretic variants of β-conglycinin from soybean.

Three genes which code for variant β-conglycinin subunits were identified. Alleles Cgy 1 S and Cgy 2 S were codominant with Cgy1 and Cgy2 and produced α′ and α subunits, respectively, with reduced electrophoretic mobility. Allele Cgy 3 D increased the mobility of at least one polypeptide in the β subunit family and exhibited incomplete dominance. Gene loci Cgy2/Cgy 2 S and Cgy 3 D /cgy 3 D were linked, whereas Cgy1/Cgy 1 S / cgy1 segregated independently of the others. Techniques developed for purification of normal β-conglycinin subunits were effective in purifying the altered subunits. Deglycosylated variant proteins from seeds containing the alleles Cgy 1 S , Cgy 2 S , or Cgy 3 D also has altered mobility relative to deglycosylated normal proteins. Therefore, the altered subunits contained changes in their amino acid sequences rather than in their carbohydrate moieties. This interpretation is consistent with the observed codominant or incompletely dominant mode of inheritance for these alleles and suggests that each contains an altered nucleotide sequence in the structural gene. A fourth variant, which exhibited doublet α′ and a electrophoretic bands, was inherited in a recessive fashion. Deglycosylated subunit proteins from this variant were identical in electrophoretic mobility to those of the deglycosylated normal protein. This suggests that the doublet phenotype resulted from an alteration in the carbohydrate moiety of these subunits. The gene or genes which condition this variant presumably are required for normal post-translational modification of the subunit carbohydrates and as such may be useful for investigating these events.
Lokomat Training to Improve Gait in Multiple Sclerosis and Freezing of Gait in Parkinson’s Disease

Gait dysfunction is an area of considerable disability for people with multiple sclerosis (MS) and Parkinson’s disease (PD). The use of robot-assisted gait training is a potential technology-based intervention to treat gait impairment. Twenty-five people with MS and PD were enrolled in separate clinical studies and treated with up to 16 sessions of robot-assisted gait training. Outcomes collected included quantitative temporal-spatial gait data, as well as patient self- reported quality of life. Our findings show that robot-assisted gait training can result in positive improvements in gait and quality of life in the MS population and reduce freezing of gait in the PD population.
An object-oriented SECS programming environment

An object-oriented programming (OOP) environment for developing SEMI Equipment Communication Standard (SECS) applications with the C++ and C programming languages in a Unix workstation environment is described. The system defines a set of programming objects corresponding to the standard SECS-II item types, messages and headers as well as a number of support classes and operations. Conversion between standard program datatypes and SECS-II items is transparent or explicitly managed by the developer. Within a standard framework using standard C++ input/output methods, SECS-II messages may be created, analyzed, transmitted and received between internal buffers, external files and communication channels. Classes corresponding to specific SECS stream and function codes are also available and can be incorporated easily into application code with little or no modification. >
Towards A Theoretical Foundation for Web Services - The Language-Action Perspective (LAP) Approach

The purpose of this paper is to stimulate a discourse and search for appropriate theoretical foundations for Web services. The complexity of Web services technology demands such a foundation. A theoretical foundation can provide adequate guidance not only to accelerate research related to Web services, but can also promote their acceptance. Based on an extensive review of prior work in SCC and ICWS, we identify theories implicitly used for Web services research, and propose the language-action perspective (LAP) as an important and necessary complement to these. Our proposal follows the observation that there is a close match between the core concerns of Web services and the LAP approach. Our ongoing work is aimed at validating appropriateness of LAP as a theoretical framework for Web services through empirical research.
Tumor dormancy induced by downregulation of urokinase receptor in human carcinoma involves integrin and MAPK signaling.

Mechanisms that regulate the transition of metastases from clinically undetectable and dormant to progressively growing are the least understood aspects of cancer biology. Here, we show that a large (∼70%) reduction in the urokinase plasminogen activator receptor (uPAR) level in human carcinoma HEp3 cells, while not affecting their in vitro growth, induced a protracted state of tumor dormancy in vivo, with G0/G1 arrest. We have now identified the mechanism responsible for the induction of dormancy. We found that uPA/uPAR proteins were physically associated with α5β1, and that in cells with low uPAR the frequency of this association was significantly reduced, leading to a reduced avidity of α5β1 and a lower adhesion of cells to the fibronectin (FN). Adhesion to FN resulted in a robust and persistent ERK1/2 activation and serum-independent growth stimulation of only uPAR-rich cells. Compared with uPAR-rich tumorigenic cells, the basal level of active extracellular regulated kinase (ERK) was four to sixfold reduced in uPAR-poor dormant cells and its stimulation by single chain uPA (scuPA) was weak and showed slow kinetics. The high basal level of active ERK in uPAR-rich cells could be strongly and rapidly stimulated by scuPA. Disruption of uPAR–α5β1 complexes in uPAR-rich cells with antibodies or a peptide that disrupts uPAR–β1 interactions, reduced the FN-dependent ERK1/2 activation. These results indicate that dormancy of low uPAR cells may be the consequence of insufficient uPA/uPAR/α5β1 complexes, which cannot induce ERK1/2 activity above a threshold needed to sustain tumor growth in vivo. In support of this conclusion we found that treatment of uPAR-rich cells, which maintain high ERK activity in vivo, with reagents interfering with the uPAR/β1 signal to ERK activation, mimic the in vivo dormancy induced by downregulation of uPAR.
Preconditioning and Myocardial Angiogenesis

In the Western World ischemic coronary disease is the leading cause of morbidity and mortality. Therapeutic approaches mostly aim to restore flow to a localized segment by angioplasty or bypass surgery. In order to develop better and more effective therapeutic strategies using the powerful concept of inducing new vessel growth or by employing vascular growth factors, it is essential to further our understanding of the molecular mechanisms and the chain of events underlying the fascinating process of angiogenesis. Among the various triggers of angiogenesis, tissue hypoxia/ischemia has been identified as being a particularly important stimulus for the induction of new vessel growth. Occlusion of a main coronary depletes the blood supply to the myocardium and subsequently reduces cardiac function, which ultimately leads to heart failure. Progressive, chronic coronary artery occlusion has been shown to induce development of collateral arteries to reestablish and maintain blood flow to the myocardium at risk via the growth of new capillary vessels or angiogenesis. Studies from our laboratory as well as from others have already confirmed the protective role of collaterals against myocardial ischemia and cell death. We have successfully demonstrated in adult rat myocardium (LV) effects of hypoxia/reoxygenation on significant upregulation of the protein expression profiles of vascular endothelial growth factor (VEGF) and its tyrosine kinase receptors (Flk-1 and Flt-1) as well as other angiogenic factors such as Ang-1, Ang-2 and their receptor Tie-2. Also, we were able to demonstrate increased capillary/arteriolar density, increased capillary to myocyte cross-sectional area (after 1–4 weeks and after 2 months) and decreased collagen volume fraction by hypoxic/ischemic preconditioning in a rat model of chronic myocardial infarction (MI) model.
Polarization-sensitive second harmonic generation in the cornea

The corneal stroma is imaged by multiphoton microscopy. Second harmonic generation in stromal collagen is used to probe the symmetry elements of its nonlinear susceptibility via the polarization state of the incident light.
Modelling of Solidification Deformation in Automotive Formed Parts

The accurate prediction of part deformation due to solidification in automotive formed parts is important to help achieve an efficient production. Forming processes are those where a molten preform is deformed to take theshape of a mould cavity and subsequently solidified. Tolerance issues are critical in automotive applications and therefore part deformation due to solidification needs to be controlled and optimized accordingly. Formed parts can have a wide range of deformations according to the conditions of solidification. Both a small displacement and a large displacement formulation are developed for prediction of part deformation due to solidification. Experimental results obtained on a simple as well as complex automotive part are compared to determine whether the small displacement theory or the more complex approach is more appropriate.
Induction of disseminated virulent cytomegalovirus infection by immunosuppression of naturally chronically infected wild mice.

Wild mice immunosuppressed with antithymocytic sera show a high incidence of disseminated virulent cytomegalovirus infection.
Ruthenium-Catalyzed Amination of Secondary Alcohols Using Borrowing Hydrogen Methodology

A new ruthenium complex catalyzes the amination of primary and secondary alcohols and the regioselective mono- and sequential diamination of diols via the borrowing hydrogen pathway. Several variations on new intra- and intermolecular cyclizations of aminoalcohols, diols, and diamines lead to heterocyclic ring systems.
Development and implementation of algorithms for vehicle routing during a no-notice evacuation

AbstractThis article develops and implements time-dependent shortest path and assignment algorithms for vehicle routing and assignment during a no-notice evacuation. A time-dependent shortest path algorithm with arc labeling is designed to improve computer storage space efficiency. Visual Basic for Application (VBA) is used to improve time efficiency of both shortest path and assignment algorithms. Performance of the algorithms is analyzed and compared through implementation in VBA and the General Algebraic Modeling System (GAMS). Since VBA seamlessly integrates with Microsoft Excel and enables efficient data manipulation, the algorithms implemented in VBA are more efficient and obtain optimal solutions faster than those implemented in the GAMS. The shortest path algorithm with arc labeling implemented in VBA may be used for real-time vehicle routing for large road networks during no-notice evacuations.
Trichomalopsis dubius (Ashmead) and Dibrachys cavus (Walker): Newly Discovered Pupal Parasitoids (Hymenoptera: Pteromalidae) of House Flies and Stable Flies Associated with Livestock Manure

Trichomalopsis dubius (Ashmead) and Dibrachys cavus (Walker), pteromalid parasitoids of pupae of various muscoid flies, are reported for the first time from the hosts Musca domestica L. and Stomoxys calcitrans (L.) (Muscidae) associated with livestock manure in New York. Morphological descriptions of the male and female of both species are given, as are field and laboratory observations, biological notes and hosts summarized from the literature, and known geographic distribution. An existing illustrated key to pupal parasitoids of muscoid flies associated with livestock manure is modified to include T. dubius and D. cavus .
Forgive and Forget, or Forgive and Regret? Whether Forgiveness Leads to Less or More Offending Depends on Offender Agreeableness

How does forgiveness predict the likelihood of reoffending? One survey study, one experiment, one 4-year longitudinal study, and one 2-week diary study examined the implications of forgiveness for reoffending in relationships. In all four studies, agreeableness interacted with partner forgiveness to predict subsequent offending; partner forgiveness was negatively associated with subsequent offending among more agreeable people but positively associated with subsequent offending among less agreeable people. Furthermore, Study 4 demonstrated a unique mechanism of each simple effect; relatively agreeable people engaged in fewer transgressions against more forgiving partners because they felt obligated to refrain from transgressing against such partners whereas relatively disagreeable people engaged in more transgressions against more forgiving partners because they perceived those partners were less easily angered. These studies indicate that completely understanding the intrapersonal and interpersonal consequences of forgiveness requires recognizing the dyadic nature of forgiveness and attending to qualities of the offender.
Design and implementation of hydrological forecast output terminal based on ARM LPC2119

Due to the poor application environment,for the hydrological unit output terminal,to ensure the stability and low power consumption is particularly important.This paper presents the hydrological forecast output terminal design and implementation based on ARM7 LPC2119.By the embedded technology applied to the hydrological forecast,a minimum system is designed.In the case of someone or no one,sending the instructions of user needs through the PC or host computer to control the remote motor,in order to control the rise and fall of the gate.A detailed description of the functions of the whole system and its modules are given.The paper gives some hardware interface circuits of the power conversion module,the center module,communications module,external drive module.After the actual operation on the gate in the dujiangyan,it shows that the design is accurate and reliable.In the absence of people,it achieves the long time and low-power stable work.The design is more energy-efficient than ever before,is affordable.It has a broad application prospect in the market.
The analysis of intestinal microflora of infants with food allergy and healthy infants

Objective To detect the intestinal microflora of the infants with food allergy and healthy infants,and found a clue for the research about the relationship between the intestinal microflora and the occurrence of food allergy.Methods 52 infants with food allergy and 100 healthy infants from May,2003 to December,2003 in the Deparment of Primary Child Care,Children's Hospital,Chongqing University of Medical Sciences were choosed.The fecal samples were collected from all the subjects and were alaysed for microflora by adopting the direct and quick smear methods.Results The percentages of gram-positive rod of the samples were significantly lower,and the percentages of gram-negative rod and gram-positive cocci in the stools were significantly higher in the infants with food allergy than that in the healthy infants [(71.43±8.70)%vs(78.91±9.25)%,(15.69±6.26)%vs(11.85±6.66)%,(11.67±4.02)%vs(7.60±4.27)%,P0.001].Furthermore,there were different changes in the proportions of fecal microflora of infants with food allergy under different feeding patterns,but the percentages of gram-positive rod of the samples markedly lower was the same character(P0.05).Conclusions There were significant differences of the proportions of fecal flora between the infants with food allergy and healthy infants.Moreover,the different changes of intestinal microflora of infants under different feeding patterns were demonstrated.The changes of intestinal microflora might play a role in the onset of food allergy.
5-methyltetrahydrofolate urinary excretion: modeling by cultured human kidney cells.

Urinary folate excretion appears to be controlled by the degree of reabsorption in the renal proximal tubule.1 We have studied the membrane binding and intracellular transport of folate by cultured human proximal tubule (HPT) cells and have suggested that these cells serve as good models for renal folate reabsorption.2 However, these studies were conducted with cells grown on plastic, which exposes only the apical side to the media. To produce a better model of the transcellular transport of folate, HPT cells have been grown on microporous filter inserts in which the confluent monolayers effectively separate the apical (AP) and basolateral (BL) chambers, allowing for separate manipulation of their media contents.3 Initial experiments on the transport of 5-methyl-tetrahydrofolate (5M) in these inserts produced surprising results. A large amount of 5M was transported to the BL chamber and this was not suppressed by excess amounts of 5M, suggesting leakage through a paracellular pathway. Such a pathway should be minimized by the existence of functional tight junctions, which are normally present in confluent cultures of HPT cells.3,4 The presence of tight junctions is typically determined by measuring the transepithelial electrical resistance (TER) across the monolayer on porous membrane supports.5 The present studies were designed to assess the tight junction status during the folate transport experiments in order to overcome the “disappointing” results.
Mid Shaft Tibia Shaft Fracture Treated with Intra-medullary Nail (IMN)

A 29-year-old male presented with a midshaft tibial fracture after a motorcycle accident. He had an isolated, closed midshaft tibial fracture. There was clinical evaluation for compartment syndrome, and his pulses were well felt with no neurological injury. A long leg splint was applied.
The diet of the Lanner (Falco biarmicus) in a hyper-arid region of the eastern Sahara

The contents of regurgitated Lanner ( Falco biarmicus ) pellets and other food remains collected at four sites in the hyper-arid Darb el Arba'in Desert, southwestern Egypt, are analysed. A total of 791 bones were identified from the remains, representing a minimum of 108 individuals of 19 species of migratory birds. Quail ( Coturnix coturnix ) comprised 50% of the total number of individuals identified and 34% of the total biomass, and turtle dove ( Streptopelia turtur ) 19–4% and 19%, respectively. The balance of the other 17 species each made up less than 5% of the total number of individuals taken. No other vertebrate order was represented in the remains. It appears that Lanners arrive on the nesting grounds and commence breeding in mid-February. This allows them to utilise the massive movement of birds passing over the area between April and early May; this migration coincides with the period the falcons need to feed nestlings. During the initial stages of nesting, when few bird migrants are passing through the area, the adults feed almost exclusively on locust ( Schistocerca gregaria ).
Construction and Operation of an Affordable Laboratory Photobioreactor System for Simultaneous Cultivation of up to 12 Independent 1 L Cyanobacterial Cultures

A large field of research has developed for the study of cyanobacteria for photosynthetic chemical production. Understanding the bioenergetics of growth and product secretion of cyanobacteria requires experiments in controlled environments with volumes large enough to allow sampling over time without removing most of the culture medium. The cost of commercial laboratory photobioreactors makes these experiments inaccessible to many researchers and limits experimental throughput. In this work, we designed and constructed a system of 12 independent, sterilizable cyanobacterial photobioreactors for cultures up to 1 L in volume for a cost less than a single commercial photobioreactor. This system allows gas mixing to a desired CO2 concentration for transfer to the culture medium, discrete modulation of light intensity through addition/removal of fluorescent tubes, temperature control in the range of ambient temperature to 45 C, and simple sterile sampling for monitoring throughout long-term growth experiments. In the following sections, we will describe the assembly and operation of this photobioreactor system.
Causes of Deforestation in Central Maine, USA

Deforestation is taking place in many parts of the world, and forests are being cut at an unsustainable rate. In some areas, forests are being completely destroyed and the land converted to other uses such as industry and agriculture. In areas where forests remain, their aggregate value has been decreasing. Moreover, the species composition of many forests has changed considerably. As a result, the incomes of forest users have decreased; erosion, silting of streams and flooding have increased; and wildlife habitat is being destroyed (Moran and Ostrom 2005, pp. 1-3).
Intracranial hemorrhage in the setting of posterior reversible encephalopathy syndrome: two case reports and a review

Posterior reversible encephalopathy syndrome (PRES) is clinically characterized by seizures, changes in vision, altered mental status, and headache, with associated radiologic changes on brain imaging. Intraparenchymal hemorrhage is a rare complication of PRES and an atypical initial presentation of this condition. In this report, we discuss two patients who presented with multifocal cerebral hemorrhages that were later attributed to PRES. We further expand on the pathophysiology, management, and prognosis on patients with hemorrhagic PRES. Increased awareness of this complication of PRES is important in guiding prognostication and treatment.
Power Performance of YBCO Thin Films on Sapphire Substrates at Microwave Frequencies

Current high temperature superconducting (HTS) components are being assessed for application in communications satellites. To justify the routine launch of satellites with cryogenic refrigerators on board, the performance gains inherent to superconducting components must be seen in both the receiving and the transmitting systems of the satellite. In order to use HTS components in transmitters, however, better high power performance is required of the superconducting materials. The power performance of YBCO superconducting thin films on Al2O3 substrates has been examined. The measurement technique used involves inputting signals of varying power into microwave transmission lines fabricated on the films. The second and third order harmonic distortion products were observed and measured. From this data, the second and third order intercept points have been calculated, and compared to YBCO on LaAlO3. The power handling capability of the YBCO films on sapphire is improved, compared to YBCO films on lanthanum aluminate.
Theoretical Study of Cross-Valley Wind Circulation

An analytical model is developed to investigate the interaction between the large scale prevailing air flow and the thermally induced slope wind circulation. The Boussinesq approximation is assumed. The lower order successive approximation solutions are obtained in spectral representation for both typical daytime and night time cases. The results have produced interesting circulation features often observed in mountainous terrain.
FEW NUCLEON SYSTEMS: APPLICATIONS

Publisher Summary This chapter reviews the nuclear Thomas–Fermi model and some of its applications of astrophysical interest. The study of few nucleon systems has as a principle objective the determination of the nuclear forces. It can be determined from nucleon–nucleon scattering and from the nucleon–nucleon ground state. However, this analysis leaves certain ambiguities in the interaction, particularly in the off-energy shell behavior. The three-nucleon system gives necessary information concerning this problem. An essential complication arises in the three-body system from the undoubted presence of three-body interactions. At present, it is difficult to separate the uncertainties in the two-body interaction as they affect the three-body system from the contribution of the three-body interaction. The range of applications of the knowledge gained from experiment and from the theory of the two- and three-nucleon systems is equivalent to all of nuclear physics in the energy range below the pion and hyperon thresholds. The chapter discusses the study of nuclei in their ground states or in states of weak excitation, which is the classical range of nuclear physics. The calculation of ground-state properties presents quite different problems from the calculation of the properties of excited states.
Ca2+ Transients in Perfused Hearts: Fundamental Properties of the Chemical Signals Underlying Ventricular Mechanics

An increase in the intracellular free calcium concentration, [Ca2+]i, initiates contractile activation in the heart. Until recently, the changes in [Ca2+]i during the cardiac cycle (the “Ca2+ transients”) had eluded measurement. Here I describe the use of gated nuclear magnetic resonance (NMR) spectroscopy to achieve direct quantitation of the cyclical changes in [Ca2+]i that underlie mechanics in perfused ferret hearts loaded with-the fluorinated Ca2+ indicator 5F-BAPTA. [Ca2+]i increased from approximately 200 nM in diastole to 750 nM or higher in early systole. In this preparation, the effects of changing coronary arterial flow on [Ca2+]i can be investigated simultaneously with measurements of high-energy phosphate concentrations by 31P-NMR. When hypoperfusion is induced such that the pressure generated by contraction falls without metabolic evidence of ischemia (“Gregg’s phenomenon”), a decrease in the amplitude of Ca2+ transients underlies the observed fall in pressure. This down-regulation of Ca2+ transients constitutes the cellular basis for Gregg’s phenomenon, and serves to decrease energy demand during low-flow ischemia.
(1-Cyclo­pentano-4-ethyl-3-thio­semi­carbazone)­iodobis­(triphenyl­phosphino)copper(I) acetonitrile disolvate

Reaction of cyclo­penta­none N4-ethyl­thio­semicarbazone with copper (I) iodide in the presence of triphenyl phosphine as a coligand resulted in the formation of the title compound, which crystallized as the acetonitrile solvate, C44H45CuIN3P2S·2CH3CN or [CuI(C8H15N3S)(C18H15P)2]·2C2H3N. The monomeric form of the complex has a slightly distorted tetra­hedral Cu coordinated by the S atom of the thio­semicarbazone ligand, with a Cu—S distance 2.3516 (7) A. The Cu—P distances are 2.2876 (7) and 2.2959 (7) A, and the Cu—I distance is 2.6547 (4) A. One of the NH groups of the thio­semicarbazone forms an intra­molecular hydrogen bond with the I atom, while the other NH group forms a hydrogen bond to a solvent mol­ecule.
Effect of Heat Treatment on Magnetic and Electrical Properties in Fe/Al 2 O 3 Core/Shell Nanocomposites

With the development of the portable electronics devices, all electrical components, such as power chokes, are integrated with miniaturization. Magnetic-energy storaged materials play an important role in power chokes for DC/DC converters applications. Presently, NiZn-based ferrites are often used in power chokes, but the saturation magnetization Ms~60emu/g is lower due to the intrinsic structure limitations. In order to replace the ferrites for high power application, the iron-based magnetic alloy with highly Ms~180emu/g are good candidates. However, the commercial magnetic alloys are micron-sized in 20-50um with the lower electrical insulations $( and will induce the high eddy-current loss. In this research, we develop a method to fabricate the sub micron-sized ( 2 O 3 oxides are used as a starting powders and chemically precipitate the Al(OH) 3 hydroxides on the surface. These as-prepared composite are treated at 800°C for few hours in a reduced Ar/H2 atmospheres and successfully transform to the Fe/A12o3 nanocomposites. Fig show the dependences of magnetic and electrical properties on the different Al/Fe ratio. The experimental results shows the optimal Ms value~161 emu/g and electrical resistivity of $2.6\times 10^{3}\Omega-\text{cm}$ in a Al/Fe ratio of 24%. In additions, the crystallization, surface morphology and high-frequency properties are also investigated. In summary, the hydrogen reduced treatment acts as an efficient method to prepare the metal core/insuation shell nanocomposites from oxides systems. Fig: The dependences of magnetic and electrical properties on the different Al/Fe ratio.
INDEED: R package for network based differential expression analysis

With recent advancement of omics technologies, fueled by decreased cost and increased number of available datasets, computational methods for differential expression analysis are sought to identify disease-associated biomolecules. Conventional differential expression analysis methods (e.g. student’s t-test, ANOVA) focus on assessing mean and variance of biomolecules in each biological group. On the other hand, network-based approaches take into account the interactions between biomolecules in choosing differentially expressed ones. These interactions are typically evaluated by correlation methods that tend to generate over-complicated networks due to many seemingly indirect associations. In this paper, we introduce a new R/Bioconductor package INDEED that allows users to construct a sparse network based on partial correlation, and to identify biomolecules that have significant changes both at individual expression and pairwise interaction levels. We applied INDEED for analysis of two omic datasets acquired in a cancer biomarker discovery study to help rank disease-associated biomolecules. We believe biomolecules selected by INDEED lead to improved sensitivity and specificity in detecting disease status compared to those selected by conventional statistical methods. Also, INDEED’s framework is amenable to further expansion to integrate networks from multi-omic studies, thereby allowing selection of reliable disease-associated biomolecules or disease biomarkers.
Bioorthogonal nanozymes: progress towards therapeutic applications.

Bioorthogonal nanocatalysts, also known as nanozymes, are promising tools to generate imaging and therapeutic molecules in living systems, through transformations that cannot be performed by cellular machinery. This emerging platform is rapidly evolving towards the creation of smart nanodevices capable of accumulating in targeted cells/tissues, as well as controlling their catalytic activity through chemical and physical signals. In this review, we describe different strategies for fabricating these nanocatalysts and their potential in diagnostic and therapeutic applications. In addition, we discuss the latest advances and envisaged challenges in the use of bioorthogonal nanocatalysis to treat diseases in animal models.
Relationships between three and twelve month outcomes in children enrolled in the therapeutic hypothermia after pediatric cardiac arrest trials.

Abstract Aim To inform design aspects of future trials by comparing 3 and 12-month neurobehavioural outcomes in children enrolled in Therapeutic Hypothermia After Pediatric Cardiac Arrest Out-Of-Hospital and In-Hospital (THAPCA-OH, THAPCA-IH) trials. Methods The THAPCA trials evaluated two targeted temperature management interventions (hypothermia, 32.0–34.0 °C; normothermia, 36.0–37.5 °C). Children, aged 2 days to Results VABS-II and PCPC were available at 3 and 12 months in 204 of 222 eligible survivors (THAPCA-OH, n = 82; THAPCA-IH, n = 122). Relative to THAPCA-IH, THAPCA-OH had significantly less pre-CA disability and significantly greater 12-month CA impairment, based on both VABS-II and PCPC. Correlations between 3 and 12-month VABS-II scores were strong for THAPCA-OH (r = 0.95) and THAPCA-IH (r = 0.72), and lower (p ≤ 0.001) in THAPCA-IH. Between time-points correlations were lower, but still significant in children Conclusions In future paediatric cardiac arrest clinical trials that enroll similar cohorts, integration of 3-month neurobehavioral outcome measures should be considered.
Abstract 1191: PD-L1 expression and the tumor immune microenvironment in NUT carcinoma

Nuclear protein in testis (NUT) carcinoma is a rare, highly aggressive malignancy that is defined by translocations of the NUTM1 gene and has a median survival of less than one year. Although immunotherapy is an attractive novel therapeutic option, the immune microenvironment has not yet been characterized in this tumor type. We performed immunohistochemistry for PD-L1, IDO1, CD8, CD68, FOXP3 and myeloperoxidase on whole-slide sections from 9 cases of NUT carcinoma, quantified immune cell subsets using Halo image analysis software, manually scored percentage of PD-L1 and IDO1 expression in tumor cells, and classified immune cell PD-L1 expression as focal (≤5%) or non-focal (>5%). The 9 NUT carcinomas included 6 sinonasal, 2 mediastinal, and 1 soft tissue primaries. Median survival was 11 months (range 2-19); 7 patients (78%) died of disease while 2 (22%) had no evidence of disease at last follow up (12 and 19 months). All tumors demonstrated a dominant population of myeloperoxidase+ neutrophils, with a mean density of 954/mm2 (range 14-2311). There were also a mean 59/mm2 CD8+ cytotoxic T-cells (range 15-107), 75/mm2 FOXP3+ T-regulatory cells (range 9-349), and 54/mm2 CD68+ macrophages (range 0-417). Immune cell density did not correlate with survival. Four tumors (44%) expressed PD-L1, with mean 17% positivity (range 0-70%). PD-L1 expression was associated with improved survival (p=0.02), with higher mean PD-L1 levels in surviving patients (65% vs. 4%, p Note: This abstract was not presented at the meeting. Citation Format: Lisa M. Rooper, Nyall R. London, Janis M. Taube, William H. Westra, Justin A. Bishop, Hyunseok Kang. PD-L1 expression and the tumor immune microenvironment in NUT carcinoma [abstract]. In: Proceedings of the American Association for Cancer Research Annual Meeting 2019; 2019 Mar 29-Apr 3; Atlanta, GA. Philadelphia (PA): AACR; Cancer Res 2019;79(13 Suppl):Abstract nr 1191.
18F-FDG Is a Superior Indicator of Cognitive Performance Compared to 18F-Florbetapir in Alzheimer's Disease and Mild Cognitive Impairment Evaluation: A Global Quantitative Analysis.

BACKGROUND 18F-Fluorodeoxyglucose (18F-FDG) positron emission tomography (PET) and 18F-florbetapir PET are approved neuroimaging biomarkers for the Alzheimer's disease (AD) and mild cognitive impairment (MCI). OBJECTIVES This study aims to compare the efficacy of 18F-FDG and 18F-florbetapir PET at evaluating the cognitive performance of patients with AD, MCI, and normal controls (NC). METHODS 63 subjects (36 male/27 female, mean age = 68.3) including 19 AD, 23 MCI, and 21 NC underwent 18F-FDG and 18F-florbetapir PET imaging. A global quantification approach was applied on supra-tentorial, frontal, parieto-occipital, temporal, and cerebellar brain regions by calculating the global SUVmean ratios (GSUVr) as the weighted average of all regional SUVmean. 18F-FDG and 18F-florbetapir GSUVr of each region were subsequently correlated with the Mini-Mental State Examination (MMSE). RESULTS Subjects were studied in five categories as NC, MCI patients, AD patients, MCI and AD patients grouped together (MCI/AD), and a group including all the subjects (NC/MCI/AD). Both 18F-FDG and 18F-florbetapir could successfully detect subjects with dementia (p < 0.001). Studied in all regions and groups, the correlation analysis of 18F-FDG GSUVr with MMSE scores was significant in more regions and groups compared to that of 18F-florbetapir. We also demonstrated that the correlation of 18F-FDG GSUVr with MMSE is stronger than that of 18F-florbetapir in the supra-tentorial and temporal regions. CONCLUSIONS This study reveals how 18F-FDG-PET global quantification is a superior indicator of cognitive performance in AD and MCI patients compared to 18F-florbetapir PET. Accordingly, we still recommend 18F-FDG-PET over amyloid imaging in the evaluation for AD and MCI.
The Impact of Political Change on the State of Academia Including Academic Freedom in the Arab World: Libya as a Case Study

Furthering Western style academic freedom has been challenging, as Arab countries, especially Libya, have known only autocratic regimes throughout their modern existence. Amidst its current politic...
Emerging Technology Trends in Vehicle-to-Everything Connectivity

Connected cars, with sensors/embedded devices, offer conveniences/infotainment/navigation/safety, a significant component of Internet-of-Things (IoT), make it safer for everyone sharing the road. These devices constitute an in-vehicle network and communicate over wired interfaces enabling data exchange within cars. Wireless communications technology has become vital for safety as vehicles communicate with surroundings (vehicles/pedestrians/infrastructures) and exchange messages for increased road safety, traffic flow control and notifications. We provide an overview of connectivity: in-vehicle and between-vehicles-&-others (vehicle-to-everything-V2X) and make recommendations with possible next-generation evolution paths. We discuss communication options suitable for designing technical solutions to fulfill enhanced V2X (eV2X) requirements and address some challenges that arise in densely populated vehicle environments with increased mobility, heightened safety, and high bandwidth demands.
JOURNEY OF THE NOTOCHORD: LINKING EMBRYOLOGY TO RADIOLOGIC INTERPRETATION OF THE CRANIOCERVICAL JUNCTION

Background The notochord is a mesoderm-derived cylindrical midline structure and a defining feature found in all chordates. In vertebrates, the notochordal process represents the initial embryologic axial skeleton and plays important structural and signaling roles in the development of the vertebral column, nervous system, and skull base. Besides persisting postnatally as the nucleus pulposus of the intervertebral disks, the remaining notochord typically regresses during fetal development after completion of its principal tasks. However, remnants of the notochord can persist along its developmental path within the craniocervical region. These remnants present as a spectrum of entities, ranging from anatomic variants, benign tumors, and malignant neoplasms of notochordal origin. Radiologists who interpret imaging in the area along the embryologic path of the notochord should be knowledgeable about its development and be able to recognize its wide array of potential pathologies. Discussion This presentation will review notochord embryology and the anatomic and pathologic relevance of notochordal remnants and demonstrate the vast range of imaging features and behavioral properties of these postnatal remnants in the area of the posterior cranial base and cervical spine. We present 3 cases of inferior median clival canal, a notochordal anatomic variant typically discovered as an incidental finding. Also known as canalis basilaris medianus, this notochord remnant manifests as a narrow, well-defined corticated canal passing through the sagittal plane of the clivus. Depending on its course and extent, 2 groups with 6 subtypes have been described. We also present imaging features of pathologic abnormalities, including Tornwaldt cyst, benign remnant ecchordosis physaliphora, and chordoma, a notochord malignancy. Awareness of the full spectrum of pathologic consequences of persistent notochord tissue, recognition of their imaging features, and directing appropriate referral add to the value provided by an oral and maxillofacial radiologist.
Effect of maternal nutrient restriction on expression of glucose transporters (SLC2A4 and SLC2A1) and insulin signaling in skeletal muscle of SGA and Non-SGA sheep fetuses

Maternal nutrient restriction (NR) causes small for gestational age (SGA) offspring, which are at higher risk for accelerated postnatal growth and developing insulin resistance in adulthood. Skeletal muscle is essential for whole-body glucose metabolism, as 80% of insulin-mediated glucose uptake occurs in this tissue. Maternal NR can alter fetal skeletal muscle mass, expression of glucose transporters, insulin signaling, and myofiber type composition. It also leads to accumulation of intramuscular triglycerides (IMTG), which correlates to insulin resistance. Using a 50% NR treatment from gestational day (GD) 35 to GD 135 in sheep, we routinely observe a spectral phenotype of fetal weights within the NR group. Thus, we classified those fetuses into NR(Non-SGA; n = 11) and NR(SGA; n = 11). The control group (n = 12) received 100% of nutrient requirements throughout pregnancy. At GD 135, fetal plasma and gastrocnemius and soleus muscles were collected. In fetal plasma, total insulin was lower in NR(SGA) fetuses compared NR(Non-SGA) and control fetuses (P 0.05) for protein levels of LPL or CPT1B. Within soleus, there were no differences (P > 0.05) for any characteristic except for the proportion of type I myofibers, which was lower (P 0.05) in gastrocnemius or soleus muscles. Collectively, the results indicate molecular differences between SGA and Non-SGA fetuses for most characteristics, suggesting that maternal NR induces a spectral phenotype for the metabolic programming of those fetuses.
Optimal Timing of Palatoplasty in Infants With Comorbidities

Objective:Ideal timing of palatoplasty continues to be debated given that early repair is thought to improve speech and hearing, whereas delayed repair is associated with less midface growth disrup...
Convolutional neural network to identify symptomatic Alzheimer's disease using multimodal retinal imaging.

Background/Aims To develop a convolutional neural network (CNN) to detect symptomatic Alzheimer’s disease (AD) using a combination of multimodal retinal images and patient data. Methods Colour maps of ganglion cell-inner plexiform layer (GC-IPL) thickness, superficial capillary plexus (SCP) optical coherence tomography angiography (OCTA) images, and ultra-widefield (UWF) colour and fundus autofluorescence (FAF) scanning laser ophthalmoscopy images were captured in individuals with AD or healthy cognition. A CNN to predict AD diagnosis was developed using multimodal retinal images, OCT and OCTA quantitative data, and patient data. Results 284 eyes of 159 subjects (222 eyes from 123 cognitively healthy subjects and 62 eyes from 36 subjects with AD) were used to develop the model. Area under the receiving operating characteristic curve (AUC) values for predicted probability of AD for the independent test set varied by input used: UWF colour AUC 0.450 (95% CI 0.282, 0.592), OCTA SCP 0.582 (95% CI 0.440, 0.724), UWF FAF 0.618 (95% CI 0.462, 0.773), GC-IPL maps 0.809 (95% CI 0.700, 0.919). A model incorporating all images, quantitative data and patient data (AUC 0.836 (CI 0.729, 0.943)) performed similarly to models only incorporating all images (AUC 0.829 (95% CI 0.719, 0.939)). GC-IPL maps, quantitative data and patient data AUC 0.841 (95% CI 0.739, 0.943). Conclusion Our CNN used multimodal retinal images to successfully predict diagnosis of symptomatic AD in an independent test set. GC-IPL maps were the most useful single inputs for prediction. Models including only images performed similarly to models also including quantitative data and patient data.
Renal Collecting System Injury During Percutaneous Nephrolithotomy, More Likely When Using Continuous Flow Sheaths?

Background: Renal collecting system injuries are a rare occurrence during percutaneous nephrolithotomy (PCNL). However, when they do happen, the potential for complications rises exponentially the longer the injury goes undetected. This case highlights a possible higher rate of injury when using continuous flow sheaths. Case Presentation: A 65-year-old woman with history of large volume obstructing left-sided renal pelvis stone had an emergent ureteral stent placed for infection and was referred for interval management. Patient was taken for PCNL in the prone split-leg position where a continuous flow ureteral access sheath and a continuous flow nephrostomy sheath was used. Puncture and dilatation were performed under endoscopic guidance to avoid collecting system injury during access. The anesthesiologist discovered abnormalities in the patient's pulmonary ventilation settings. This allowed the surgical team to quickly halt the procedure and place the patient supine where a distended abdomen was discovered consistent with irrigation fluid extravasation into the abdominal cavity. Given concern for abdominal compartment syndrome, interventional radiology was then called to assist in placing a drain in the right lower quadrant of the patient to evacuate the irrigation fluid. This is the second such occurrence in a span of 6 months when using continuous flow ureteral access and nephrostomy sheaths. Conclusion: Renal collecting systems injuries are infrequent when access is obtained under endoscopic guidance. Prompt recognition of physiologic breathing abnormalities allowed the surgical team to quickly treat the injury, preventing further complications from arising in the setting of a diagnosis where time to detection plays an important role in prognosis. However, given that this is the second such injury, the usage of continuous flow sheaths and their rate of associated complications and injuries must be thoroughly examined.