Abstract 1873: Serum vitamin D levels and prostate volume

Proceedings: AACR 106th Annual Meeting 2015; April 18-22, 2015; Philadelphia, PA Introduction: We investigate the association between serum 25-hydroxyvitamin D (25-OH D) levels and prostate volume, PSA, and PSA density (PSAD) given literature linking vitamin D with prostate proliferation. Procedures: From 2010-13, we enrolled 40-79 year old ambulatory men undergoing trans-rectal ultrasound (TRUS) guided prostate biopsy for elevated PSA or abnormal DRE from academic, outpatient urology clinics in Chicago, IL. Men with PSA > 50ng/ml were excluded. Clinical and demographic data were collected by self-administered questionnaires and chart review. Venipuncture for serum 25-OH D and prostate volume estimation by the ellipsoid formula were done during TRUS. PSAD was calculated as the pre-biopsy serum PSA (ng/ml) divided by the prostate volume (cm3). The association of prostate volume, PSA, and PSAD with 25-OH D was assessed using univariate analysis of variance with 25-OH D as a categorical variable. Best fit linear regressions were constructed for multivariate analysis of this association adjusted for age, BMI, serum 25-OH D, PSA, 5-alpha reductase inhibitor (5-ARI), alcohol and tobacco use. Results: We had 364 cases (median age 62.4) and 186 negative biopsies (NBx, median age 62.1, p = 0.046). European Americans comprised 41.4% of cases vs 39.3% of NBx (p = 0.55). Cases had more PCa family history (25.5 vs 14.4% in NBx, p = 0.0001) but had smaller prostate volume relative to NBx (35.4 vs 50.5cm3, p <0.0001). On univariate analysis, serum 25-OH D was negatively associated with prostate volume and serum PSA and was statistically significant for the cases and negative biopsy groups. On linear regression, 25-OH D was negatively associated with prostate volume, PSA, and PSAD (Table 1). Conclusion: Vitamin D is more strongly correlated with prostate volume than serum PSA. This suggests an anti-proliferative role for vitamin D in BPH/LUTS and PCa and warrants more study. Funding: None Table 1: Linear Regression Models for Prostate Volume, PSA and PSAD | Dependent Variables | Prostate Volume | Serum PSA | PSA Density | |:--------------------- | ---------------------- | --------------------- | ------------------- | -------------------- | | | β (CI) | β (CI) | β (CI) | | Independent Variables | PCa | NBx | PCa | NBx | PCa | NBx | | Age | *0.41 (0.09, 0.73) | *1.01 (0.38, 1.65) | 0.03 (-0.09, 0.15) | 0.08 (-0.05, 0.21) | -0.002 (-0.01, 0.002) | -0.002 (-0.01, 0.001) | | BMI | *0.64 (0.20, 1.1) | *1.14 (0.16, 2.11) | -0.07 (-0.23, 0.10) | 0.13 (-0.07, 0.34) | *-0.01 (-0.01, -0.001) | 0.001 (-0.01, 0.01) | | 25-OH D | -0.13 (-0.34, 0.07) | *-0.55 (-0.97, -0.14) | -0.10 (-0.18, 0.02) | *-0.08 (-0.16, 0.00) | -0.001 (-0.003, 0.001) | -0.001 (-0.004, 0.002) | | Serum PSA | *0.29 (0.02, 0.56) | *0.61 (-0.001, 1.22) | - | - | - | - | | 5-ARI use | *8.60 (-1.13, 18.33) | 10.14 (-2.25, 22.53) | 5.57 (2.06, 9.08) | *6.57 (3.93, 9.21) | 0.04 (-0.07, 0.15) | 0.06 (-0.02 - 0.14) | | Cig. Use | *-7.13 (-11.51, -2.76) | -9.53 (-19.10, 0.04) | 0.43 (-1.19, 2.06) | 0.32 (-1.64, 2.29) | 0.05 (-0.001, 0.10) | 0.02 (-0.05, 0.08) | | Alc. Use | -1.55 (-8.44, 5.35) | 1.58 (-11.13, 4.29) | -2.20 (-4.78, 0.39) | -1.26 (-4.07, 1.55) | -0.03 (-0.11, 0.05) | -0.08 (-0.16, 0.01) | Covariates with * reached significance, p<0.05. Citation Format: Richard U. Kalu, Adam B. Murphy, Yaw Nyame, Gregory A. Jordan, Rick A. Kittles. Serum vitamin D levels and prostate volume. [abstract]. In: Proceedings of the 106th Annual Meeting of the American Association for Cancer Research; 2015 Apr 18-22; Philadelphia, PA. Philadelphia (PA): AACR; Cancer Res 2015;75(15 Suppl):Abstract nr 1873. doi:10.1158/1538-7445.AM2015-1873