cssi/SciSciGPT-SciSciNet huggingface dataset:
Arteriovenous hemangioma: a clinicopathological and immunohistochemical study

The clinicopathological and immunohistochemical properties of 6 examples of arteriovenous hemangioma, including 2 intraoral lesions, were reviewed. This distinct benign, acquired vascular lesion, infrequently encountered in the literature, is characterized by multiple thick- and thin-walled vascular spaces resembling arteries and veins, respectively. In our study, we performed elastic stains that revealed a prominent venular component, whereas the arterial aspect was inconspicuous to absent. Our aim was also to elucidate the possible histogenesis of this lesion. Previous reports suggest as pathogenetic mechanisms hamartomatous proliferation either of the subpapillary vascular plexus or of the Suquet-Hoyer canal of the true glomus. Our immunohistochemical studies failed to identify typical glomus cells. In addition, we investigated the mast cell count in all lesions and it was found increased. These findings, as well as recent evidence directly implicating mast cells in angiogenesis, can support the theory of hamartomatous proliferation of the subpapillary plexus. One should also not exclude the possibility of a reactive process resulting in the characteristic features of arteriovenous hemangioma.
Why Deliberative Democracy Is Different

In modern pluralist societies, political disagreement often reflects moral disagreement, as citizens with conflicting perspectives on fundamental values debate the laws that govern their public life. Any satisfactory theory of democracy must provide a way of dealing with this moral disagreement. A fundamental problem confronting all democratic theorists is to find a morally justifiable way of making binding collective decisions in the face of continuing moral conflict.
How to Tell a New Story About Battering

As Evan Stark observes, getting domestic violence against women recognized as coercive control will require a major effort of storytelling. Women's accounts of subjugation have to be narrated in a way that is both true to their experiences and capable of eliciting public understanding, sympathy, and action. This essay draws on an interdisciplinary literature on narrative to show why doing that poses such a formidable challenge. In lieu of the tragic form that has dominated battered women's storytelling, and in lieu of the quest and mystery forms that appear in Stark's own accounts, this article argues for using a rebirth story line.This genre, which has affinities with the fairytales Snow White and Sleeping Beauty, seems an unlikely vehicle for asserting battered women's combination of victimization and agency. Drawing on the stories told by battered women as part of a successful reform effort, however, this article shows how women have used the form effectively.
Mutational analysis of the cytoplasmic domain of β1,4- galactosyltransferase I: influence of phosphorylation on cell surface expression

Beta1,4-galactosyltransferase I (GalT I) exists in two subcellular compartments where it performs two distinct functions. The majority of GalT I is localized in the Golgi complex where it participates in glycoprotein biosynthesis; however, a small portion of GalT I is expressed on the cell surface where it functions as a matrix receptor by binding terminal N-acetylglucosamine residues on extracellular glycoside ligands. The GalT I polypeptide occurs in two alternate forms that differ only in the length of their cytoplasmic domains. It is thought that the longer cytoplasmic domain is responsible for GalT I function as a cell surface receptor because of its ability to associate with the detergent-insoluble cytoskeleton. In this study, we demonstrate that the long GalT I cytoplasmic and transmembrane domains are capable of targeting a reporter protein to the plasma membrane, whereas the short cytoplasmic and transmembrane domains do not have this property. The surface-localized GalT I reporter protein partitions with the detergent-insoluble pool, a portion of which co-fractionates with caveolin-containing lipid rafts. Site-directed mutagenesis of the cytoplasmic domain identified a requirement for serine and threonine residues for cell surface expression and function. Replacing either the serine or threonine with aspartic acid reduces surface expression and function, whereas substitution with neutral alanine has no effect on surface expression or function. These results suggest that phosphorylation negatively regulates GalT I function as a surface receptor. Consistent with this, phosphorylation of the endogenous, full-length GalT I inhibits its stable expression on the cell surface. Thus, the 13 amino acid extension unique to the long GalT I isoform is required for GalT I expression on the cell surface, the function of which is regulated by phosphorylation.
Differential modulation of root formation in wheat embryogenic callus culture by indoleacetic acid-degrading compounds

Root overproduction in embryogenic calli of wheat cv. «Chinese Spring» was controlled by the addition of IAAdegrading compounds (citric acid, MnSO 4 or EDTA) to the culture media. In the presence of 20 g l −1 sucrose, the number of roots on calli decreased significantly when media for either callus maintenance or plant regeneration were amended with citric acid. EDTA was less effective in reducing the number of roots than citric acid. An increase in the amount of a 31 kDa (P1) polypeptide under conditions which favoured a reduction in root formation was observed
Cameras and Pervasive Information Systems

Smart cameras combine imaging and computation in a single node. Smart cameras allow us to operate on video in real time and to analyze video in a distributed manner. VLSI technology is capable of delivering large quantities of inexpensive, powerful smart cameras. This talk will describe the smart cameras developed by the Embedded Systems Group at Princeton University as well as some uses of this technology in pervasive information systems.
Dynamic range considerations for general aviation receivers in the VHF range

The work performed showed that SiC diode mixers offer the potential for very high performance mixers with reasonably low local oscillator levels. However, to take advantage of a high performance mixer, a receiver must provide a local oscillator of low spurious and phase noise. Furthermore, a high dynamic range mixer cannot provide enhanced performance unless an effective RF filter and shielding is provided in the receiver. For the future environment, which will include additional on board transmitters, airborne receivers must be designed to have high dynamic range.
The role of implicit motivation in hot and cold goal pursuit: Effects on goal progress, goal rumination, and emotional well-being

Two cross-sectional studies examined the role of implicit motivational needs in the association between personal goal pursuits and depressive symptoms and affect. Replicating and extending on findings reported by Brunstein et al. [Brunstein, J. C., Schultheiss, O. C., & Grassmann, R. (1998). Personal goals and emotional well-being: The moderating role of motive dispositions. Journal of Personality and Social Psychology, 75(2), 494–508], both studies provided evidence that goal progress significantly accounted for variations in depressive symptoms and happiness only in individuals with high levels of implicit motivation, but not in individuals low in implicit motivation. Moreover, in the absence of a strong sense of goal commitment, high levels of implicit motivation were associated with high goal progress in both studies and low levels of goal rumination in Study 2. These findings are interpreted within a dual-systems framework of motivation that distinguishes an implicit, intuitive, and hedonically driven from an explicit, effortful-analytical, and non-hedonic mode of goal pursuit.
Correlation of plasma 25-hydroxyvitamin D levels with severity of primary hyperparathyroidism and likelihood of parathyroid adenoma localization on sestamibi scan.

Objectives To determine the relationship between preoperative plasma 25-hydroxyvitamin D (25[OH]D) levels and severity of primary hyperparathyroidism (PHPT) and to explore whether presurgical 25(OH)D levels could predict the likelihood of positive results on technetium Tc 99m sestamibi scintigraphy. Design Retrospective analysis. Setting Tertiary university referral center. Patients A total of 421 consecutive patients underwent preoperative sestamibi scintigraphy and parathyroid exploration. Patients with cholecalciferol (vitamin D) deficiency, defined as plasma levels lower than 25 ng/mL, were compared with patients having no vitamin D deficiency. We explored the relationship between 25 (OH)D levels and intact parathyroid hormone (iPTH) levels, alkaline phosphatase (ALKP) levels, adenoma weight, binary sestamibi scan results, and postoperative serum calcium levels (at 1 week and 6 months). Main Outcome Measures We hypothesized that severity of hypovitaminosis D would correlate with severity of PHPT and predict the likelihood of a positive finding on sestamibi scan. Results Concentrations of iPTH and ALKP and parathyroid adenoma weight were significantly higher in patients with lower 25(OH)D levels ( P P P Conclusions Patients with hypovitaminosis D present with more advanced indices of PHPT. Parathyroid sestamibi scanning is more likely to show positive results for this subset of patients who may then benefit from sestamibi scan–directed surgical intervention.
Mindfulness and De-Automatization

Some maladaptive thought processes are characterized by reflexive and habitual patterns of cognitive and emotional reactivity. We review theoretical and empirical work suggesting that mindfulness—a state of nonjudgmental awareness of the present moment—can facilitate the discontinuation of such automatic mental operations. We propose a framework that suggests a series of more specific mechanisms supporting the de-automatizing function of mindfulness. Four related but distinct elements of mindfulness (awareness, attention, focus on the present, and acceptance) can each contribute to de-automatization through subsequent processes, including discontinuing automatic inference, enhancing cognitive control capacity, facilitating metacognitive insight, and preventing suppression or thought distortion. De-automatizing can, in turn, allow enhancement of adaptive self-control ability and increased well-being.
Open-Curve shape correspondence without endpoint correspondence

Shape correspondence is the foundation for accurate statistical shape analysis; this is usually accomplished by identifying a set of sparsely sampled and well-corresponded landmark points across a population of shape instances. However, most available shape correspondence methods can only effectively deal with complete-shape correspondence, where a one-to-one mapping is assumed between any two shape instances. In this paper, we present a novel algorithm to correspond 2D open-curve partial-shape instances where one shape instance may only be mapped to part of the other, i.e., the endpoints of these open-curve shape instances are not presumably corresponded. In this algorithm, some initially identified landmarks, including the ones at or near the endpoints of the shape instances, are refined by allowing them to slide freely along the shape contour to minimize the shape-correspondence error. To avoid being trapped into local optima, we develop a simple method to construct a better initialization of the landmarks and introduce some additional constraints to the landmark sliding. We evaluate the proposed algorithm on 32 femur shape instances in comparison to some current methods.
UltiMOS: A local charge-balanced trench-based 600V super-junction device

This paper for the first time reports on a novel “local” charge balanced trench-based super junction transistor. The local charge balance is achieved by selectively growing thin highly-doped n-type and p-type layers in a deep trench structure. The final charge-balanced trench structure is finished with an oxide-sealed airgap. Devices rated at 10A with V bd =730V and a Ron=23 mΩ.cm2 are demonstrated.
Reduction of cardiac fibrosis decreases systolic performance without affecting diastolic function in hypertensive rats

Pressure-overload left ventricular hypertrophy (LVH) is characterized by an increase in myocyte size and fibrosis. However, it is not clear how each of these components affects hypertensive heart disease (HHD). We have shown in 2 different rat models of hypertension that cardiac fibrosis can be reduced with N-acetyl-seryl-aspartyl-lysyl-proline (Ac-SDKP), an antifibrotic peptide normally present in mammals. To assess how inhibition of fibrosis affects HHD, spontaneously hypertensive rats (SHR) and normotensive controls (WKY) were treated with Ac-SDKP or vehicle. Cardiac systolic and diastolic function were assessed using in vivo pressure-volume (PV) analysis. Left ventricle passive compliance was also determined ex vivo. We found that in SHR, Ac-SDKP normalized left ventricle total collagen content and interstitial collagen fraction without changing myocyte diameter or left ventricle mass. In WKY, collagen did not change significantly after treatment. Ac-SDKP did not affect left ventricle diastolic function, determined in vivo and ex vivo in SHR and WKY, whereas systolic function was significantly decreased in SHR treated with Ac-SDKP and unchanged in treated WKY. We concluded that in adult SHR, reducing left ventricle collagen deposition with Ac-SDKP does not improve diastolic function, whereas it decreases systolic performance. These findings suggest that total left ventricle collagen reduction per se does not necessarily benefit cardiac function. In HHD, other factors besides collagen quantity, such as myocyte hypertrophy and/or collagen type or cross-link, might be targeted to improve cardiac function.
Globalization: Civilizing or destructive? An empirical test of the international determinants of generalized trust:

Does globalization encourage and facilitate the development of generalized trust, or does it, on the contrary, foster mutual suspicion and distrust? This question preoccupied intellectual elites du...
Development and preliminary validation of the MedRisk instrument to measure patient satisfaction with chiropractic care.

Abstract Objective The purpose of this study is to provide preliminary information regarding the factor-structure, group- and individual-level reliability, and criterion-referenced validity of measures obtained from the MedRisk Instrument for Measuring Patient Satisfaction with Chiropractic Care. Method Three hundred twenty-three subjects who had completed a course of chiropractic care responded to questionnaire in which they rated their degree of satisfaction from 1 to 5 (1 = very unsatisfied to 5=very satisfied) for each of 20 items. Factor structure was assessed using item-correlation and exploratory factor analysis. Group-level reliability for single test administration was assessed by calculating Cronbach α , and individual-level reliability was determined using the standard error of measure. Criterion-referenced validity was investigated by comparing the item scores and mean scores of individual factors to global measures of satisfaction. Results Individual item scores ranged from 3.98 for "Office location was convenient" to 4.77 for "My chiropractor treats me respectfully." The items that were most highly correlated with overall patient satisfaction were "My chiropractor thoroughly explained the treatment I received" ( r = 0.77) and "My chiropractor answered all of my questions" ( r = 0.71). Exploratory factor analysis suggested a 2-factor solution: a 5-item "internal" factor and a 6-item "external" factor. The mean scores from these factors were correlated with the 2 global measures ranging from r = 0.68 to r = 0.80. The standard error of measure was 0.20 for the internal factor and 0.17 for the external factor. Conclusions Preliminary assessment suggests that a 13-item version of the MedRisk instrument provides psychometrically sound measures to assess patient satisfaction with chiropractic care; however, additional confirmatory validation should be performed.
Parameter estimation in 2D fields

The problem of estimating the parameters of noncausal finite lattice Gauss Markov random fields is addressed. It is shown how the structure of the potential matrix (the inverse of the field covariance matrix) can be used to specify the valid parameter space and formulate a computationally practical maximum likelihood estimation procedure. A modification that enables this to generate accurate parameter estimates from noisy data is provided. >
DISplay: a system for visual-interaction in distributed simulations

We propose an application-independent visual interaction library (VIL) well suited to distributed simulation. Advantages of this system include ease of use, flexibility, code reuse, and modularity. Our design ideas are manifest, in the DISplay system, a graphical user-interaction and display library which binds to any parallel software system. We provide examples of its interactive use in the the dynamic display of results from sequential queueing simulations, and distributed particle-physics simulations. These examples illustrate synchronization of multiple remote display requests and potential for enhanced parallel simulation. Also presented are provisions for customized user-interaction dialogs-for application-related input, and bi-directional interaction-between user and application.
Hypervariable or Hyperdiverse, an Independent Assessment of the Taxonomically Confusing Land Snail Genus Tropidophora (Pomatiidae: Littorinoidea: Caenogastropoda) in Madagascar*

Abstract: The terrestrial littorinoid snail genus Tropidophora Troschel, 1847 is especially diverse on Madagascar with 94 currently recognized species and numerous named varieties. Supposed high within-species variation in shell and genital morphology led some researchers to suggest that these characters may be too variable to distinguish species, prompting them to conclude that the group may be taxonomically over-split. Recent sampling allows an independent test using COI sequence data which suggests that Madagascar's Tropidophora species are not over-named but are more diverse than previously thought. Molecular diversity is congruent with traditional morphology-based species concepts suggesting that future work using both molecular and morphological data sets will be useful in a taxonomic revision of the genus.
Underground focusing spotlight synthetic aperture radar for tunnel detection applications

This work studies the concept of a Underground Focusing Plane-Based Synthetic Aperture Radar (UF-SL-SAR) by analyzing two different scenarios. The first scenario is a sandy, non-dispersive, homogeneous and rough soil. In this case successful underground focusing can be performed and the scattered field produced by the tunnel just above the rough surface dominates that of by the rough ground surface alone. On the other hand, when a lossy, dispersive, homogeneous and rough clay loan soil is used, the amount of scattered field achieved just above the ground is not enough to perform a suitable tunnel detection, because the field scattered by the rough surface is dominant in this case.
The Transitions Program: A Precollege Advising and Orientation Workshop for Students and Parents

The authors describe the rationale behind, processes related to, and evaluation of The Transitions Program, a precollege advising and orientation program for students and parents. The program advisors educate participants about realistic college-life expectations and provide them with strategies for meeting the challenges and opportunities of the college transition. Students and parents responded separately to a questionnaire designed to sensitize them to college transition challenges. They were subsequently led by professional staff, faculty advisors, and students through a discussion of expected experiences. Survey results, discussion summaries, and suggestions for advisor follow-up activities are provided.
The effect of a Sporosarcina ureae preparation on tumor cells in vitro.

SummaryThe incubation of mouse spontaneous carcinoma, rabbit Brown-Pearce carcinoma, and their autologous liver slices with bacterial cultures showed in general that cells of both liver and tumor were uninjured or injured equally. Cultures of Sporosarcina ureae damaged tumor cells and left liver cells histologically unaffected. Evidence was obtained that the selective carcinoclastic factor of S. ureae cultures was contained within the cells and released on autolysis.We are indebted to Dr. C. B. van Niel of the Hopkins Marine Station for free access to the culture collection, to Colonel Max Levine for cultures of several of the Enterobaeteriaeeae, and to Dr. William Negherbon for cultures of trypanosomes and detailed directions for their maintenance.
A Generalized Synthesis Load Model Considering Fuel Cell Generation System

Based on MATLAB/Simulink tool and the theory of measurement-based load modeling method,the influences of fuel cell(FC) generation system on the load modeling of distribution network are studied.Through the analysis of dynamic operation characteristics in the transient state processes of FC generation system,FC generation system is regarded equivalent to a generalized dynamic load which consumes negative power,and can be described by second-order differential equations.Then the synthesis load model of distribution network with FC generation system is proposed.Such model is represented by the generalized synthesis load model(GSLM) of induction motor in parallel with FC and static load.The validity,the ability of interpolation and extrapolation and the stability of parameters of the proposed GSLM are testified by the analysis of simulation modeling of three typical operation states with different interference intensities.
Whatâ€™s in a Domain? Multi-Domain Learning for Multi-Attribute Data

Multi-Domain learning assumes that a single metadata attribute is used in order to divide the data into so-called domains. However, real-world datasets often have multiple metadata attributes that can divide the data into domains. It is not always apparent which single attribute will lead to the best domains, and more than one attribute might impact classification. We propose extensions to two multi-domain learning techniques for our multi-attribute setting, enabling them to simultaneously learn from several metadata attributes. Experimentally, they outperform the multi-domain learning baseline, even when it selects the single “best” attribute.
Tomorrow's implantable electronic systems

Tomorrow's implantable electronic systems are being developed using micro-machined integrated circuit technology. However, these systems will not find useful clinical applications until suitable insulating biomaterials are identified for protecting these devices from the environment of the body for many decades. A review of packaging issues for commercially successful implantable devices is followed by review of current work on developing packaging technology for tomorrow's implantable electronic systems.
Invisible Ejector Characteristic

As the conclusion after gone thru a difficult and challengeable situation, strongly recommended on enhancing the entire spange spiring type with powerfull capability to hold the unit from drop issue with 100% elaminated. Base on the testing process we able to last 50000 cycle without isuue ande by transform the number of cycle into life spend . 500000 is equivalent to 6.6 months per Nineveh high valeuem ran rate. Life span = 500000cycle / (20000 through put per year / 8 pcs pusher -pc per system) = 6.6 months
Crossing the Threshold: Bringing Biological Variation to the Foreground

Threshold concepts have been referred to as "jewels in the curriculum": concepts that are key to competency in a discipline but not taught explicitly. In biology, researchers have proposed the idea of threshold concepts that include such topics as variation, randomness, uncertainty, and scale. In this essay, we explore how the notion of threshold concepts can be used alongside other frameworks meant to guide instructional and curricular decisions, and we examine the proposed threshold concept of variation and how it might influence students' understanding of core concepts in biology focused on genetics and evolution. Using dimensions of scientific inquiry, we outline a schema that may allow students to experience and apply the idea of variation in such a way that it transforms their future understanding and learning of genetics and evolution. We encourage others to consider the idea of threshold concepts alongside the Vision and Change core concepts to provide a lens for targeted instruction and as an integrative bridge between concepts and competencies.
A free lunch proof for Gray versus Binary encodings

A measure of complexity is proposed that counts the number of local minima in any given problem representation. A special class of functions with the maximum possible number of optima is also defined. A proof is given showing that reflected Gray code induce more optima than Binary over this special class of functions; by the No Free Lunch principle, reflected Gray codes therefore induces fewer optima over all other remainin functions.
Diagnostics and prognostics using temporal causal models for cyber physical energy systems

Reliable operation of cyber-physical systems such as Power Transmission and Distribution Systems is critical for the seamless functioning of a vibrant economy. These systems consist of tightly coupled physical (energy sources, transmission and distribution lines, and loads) and computational components (protection devices, energy management systems, etc). The protection devices such as distance relays help in preventing failure propagation by isolating faulty physical components. However, these devices rely on hard thresholds and local information, often ignoring system-level effects introduced by the distributed control algorithms. This leads to scenarios wherein a local mitigation in a subsystem could trigger a larger fault cascade, possibly resulting in a blackout. Efficient models and tool that curtail such systematic failures by performing fault diagnosis and prognosis are therefore necessary.
Variation in altitudinal populations of the salamander, Bolitoglossa subpalmata , on the Cerro de la Muerte, Costa Rica

Altitudinal populations of the plethodontid salamander, Bolitoglossa subpalmata , are quantitatively compared for variation in color, pattern and size. The greatest diversity in color and pattern occurs at elevations aboye 2,900 m. Only the limbs and the gular region demonstrate a clinal character, in that they increase in the amount of redness present with higher elevation. No evidence of a size cline, either inverse or direct, has been obtained.
Measurement of Angular Acceleration

Angular acceleration was implicated as a cause of brain injury, beginning with the theory by Holbourn (1943) and the extensive research conducted by Ommaya and Hirsch (1971), Ommaya et al. (1967), and Gennarelli et al. (1982). The concept of angular acceleration was proposed by Sir Isaac Newton in the 1680s (Newton’s Principia) where he laid down the laws of motion. However, Newton did not say how this quantity could be measured. In 2-D, the measurement is accomplished by using a pair of linear accelerometers placed a known distance apart and facing the same direction (Mertz 1967). For 3-D motion, many schemes have been proposed (see, e.g., Kane 1968). It turns out that all of the schemes can potentially yield unreliable results even though the equations used are sophisticated. In this chapter, the traditional method is first described and is shown to be numerically unstable. Then a different scheme is introduced to show that it is numerically stable but requires more sensors.
Sign Language as Virus: Stigma and Relationality in Urban India.

Drawing upon ethnographic research conducted in urban locations in India, I consider the relationship between stigma and contagion in the context of deaf peoples’ desires for and practices of commu...
The Atmospheric Formation of Nitroarenes and Their Occurrence in Ambient Air

Over the last six years research has been carried out at the Statewide Air Pollution Research Center concerning the gas-phase atmospheric reactions of polycyclic aromatic hydrocarbons (РАН) and their nitro-derivatives, as well as on the ambient concentrations of the РАН and nitroarenes. This research has involved kinetic and product studies of their atmospherically important gas-phase reactions,1–17 analytical methods development and field studies to determine their ambient concentrations,18–29 and studies of the synthesis, mutagenic activities and metabolism of nitroarenes.30–34 We present here a brief overview of this research as it relates to the atmospheric formation of nitroarenes and their occurrence in ambient air.
Nondestructive Evaluation of Some Bonded Joints

Free films and lap-shear bonded metal joints were compared with respect to their linear dynamic viscoelastic behavior. Thermosetting and thermoplastic adhesives were investigated. Damping phenomena and relative shear moduli indicated a broader mechanical relaxation occurring at higher temperatures in the bonded assemblies. Triblock copolymer model adhesives were used to illustrate the importance of sample preparation in the evaluation of bonded materials.
Stimulation of the gerbil's gustatory receptors by monosaccharides.

The gustatory responses from the chorda tympani nerve of the Mongolian gerbil, Meriones unguiculatus, were treated with 13 disaccharides. Sucrose was the most stimulatory sugar. The ability of fructosyl glycosides to stimulate may depend upon the linkage between fructose and the glycoside. Disaccharides possessing 1 leads to 3, 1 leads to 4, or 1 leads to 6 linkages were poor stimuli compared to sucrose which has a 1 leads to 2 linkage. Glucopyranosyl disaccharides with an alpha-linkage were better stimuli than the beta-anomers, while galactopyranosyl disaccharides possessing a beta-linkage were better than their alpha-amoners.
A Bulky Pd(II) α-Diimine Catalyst Supported on Sulfated Zirconia for the Polymerization of Ethylene and Copolymerization of Ethylene and Methyl Acrylate

The reaction of (N∧N)PdMe2 (N∧N is Ar–N═CMeMeC═N–Ar; Ar = 2,6-bis(diphenylmethyl)-4-methylbenzene) and sulfated zirconia (SZO) in diethyl ether forms organometallic Pd-sites that polymerize ethylene and copolymerize ethylene and methyl acrylate. The Pd-sites bind CO and were studied by infrared and solid-state NMR spectroscopies. Analysis of the reaction mixture shows that more methane than expected evolves during the grafting reaction, suggesting that some Pd-sites do not contain a Pd-Me group. Consistent with this observation, deuterium labeling experiments show that ∼9% of palladium sites are active in polymerization reactions. (N∧N)PdMe2/SZO polymerizes ethylene with activity as high as 1342 kgPE/(molactive Pd*h) and incorporated up to 0.46% methyl acrylate in copolymerization reactions.
Wind Turbine Response to Analytic Inflow Vortex Parameters Variation

ABSTRACT * As larger wind turbines are placed on taller towers, rotors frequently operate in atmospheric conditions that support organized, coherent turbulent structures. It is hypothesized that these structures have a detrimental impact on the blade fatigue life experienced by the wind turbine. These structures are extremely difficult to identify with sophisticated anemometry such as ultra-sonic anemometers. In order to ascertain the idealized worst-case scenario for vortical inflow structures impinging on a wind turbine rotor, we created a simple, analytic vortex model. The Rankine vortex model assumes the vortex core undergoes solid body rotation to avoid a singularity at the vortex center and is surrounded by a 2-dimensional potential flow field. Using the wind turbine as a sensor and the FAST wind turbine dynamics code with limited degrees of freedom, we determined the aerodynamic loads imparted to the wind turbine by the vortex structure. The size, strength, rotational direction, plane of rotation, and location of the vortex were varied over a wide range of operating parameters. We identified the vortex conformation with the most significant effect on blade root bending moment cycle amplitude. Vortices with radii on the scale of the rotor diameter or smaller caused blade root bending moment cyclic amplitudes that lead to reduced fatigue life. The rotational orientation, clockwise or counter-clockwise produces little difference in the bending moment response. Vortices in the XZ plane produce bending moment amplitudes significantly
Proteomics of Nipple Aspirate Fluid in Nonlactating Women

Nipple aspirate fluid (NAF) is collected noninvasively using breast massage and a modified breast pump. The fluid contains concentrated proteins from the ductal and lobular epithelium, the source of 99% of breast cancers. The analysis of NAF has identified a number of proteins associated with the presence of breast cancer, none of which is sufficiently sensitive and specific when analyzed by itself to be clinically useful. The assessment of multiple NAF markers provides great promise in using this body fluid for early breast cancer detection. In this review, the strengths and weakness of various approaches to protein assessment in NAF are discussed.
STRATEGIES AND MEANS FOR DRUG TARGETING: AN OVERVIEW

The specificity of pharmaceuticals towards disease sites or individual diseases is usually based on a drug’s ability to interfere with local pathological processes or with defective biological pathways, but not on its selective accumulation in the specific intracellular compartment or in the target cell, organ or tissue. Traditional pharmaceutical agents, practically independent of the administration route, distribute evenly (or at least proportionally to a regional blood flow) within the body. In addition, they have to cross many biological barriers to reach the site of disease and can cause undesirable side-effects or be inactivated in organs and tissues not even involved in the pathological process. Consequently, to achieve an effective therapeutic concentration in a desired location, one has to administer the drug in large quantities, which increases the cost of the therapy and the severity of side-effects. Long ago it was hypothesized that the problem may be resolved by achieving so-called targeted drug delivery: the ability of the drug to accumulate in the target organ or tissue selectively and quantitatively, independent of the site and methods of its administration. This type of delivery was expected to increase drug concentration in the target area without any side-effects in normal tissues. For any pharmaceutical, including both therapeutic and diagnostic agents, the following advantages of a targeted delivery drug are evident: (a) simplification of administration protocols; (b) drastic reduction in the cost of therapy and drug quantity required to achieve a therapeutic effect; (c) sharp increase in drug concentration in the required sites without negative effects on non-target areas.
Digitalizing Existing Continuous-Data Control Systems Via "Continuous Frequency Matching"

Abstract A method for converting existing continuous-data control systems into digital control systems is presented in this paper. The digital controller is synthesized by matching the "continuous frequency response" of the digital control system to that of the continuous-data control system with a minimum weighted mean square error. Formulas for computing the parameters of the digital controller are obtained as a result.
Mechanisms of Fibrogenesis in Post-transplant Bronchiolitis Obliterans

Bronchiolitis obliterans (BO) post-lung transplant is a fibroproliferative disease of the small airways. Among all fibrotic diseases, BO is unique in that we have the opportunity to follow the evolution of airway remodeling and fibrosis via serial lung samplings. Although there is a definite role of immune and nonimmune injury in the pathogenesis of this disease, the physiological impairment in BO is related to fibrogenesis. Hence, understanding the pathogenesis of fibroproliferation in BO is critical for identifying targets for future therapeutic interventions and the timing of such therapy. This review updates the understanding of the cellular and molecular participants in fibrotic remodeling of the lung allograft.
Fixation of Acute and Selected Nonunion Scaphoid Fractures

At first, percutaneous techniques of scaphoid fracture reduction and fixation may appear daunting. However, with experience, they offer a powerful and versatile capability that is demonstrating promising results in the treatment of notoriously difficult fractures and nonunions. Development of small-joint arthroscopic skill is one of the essential steps in mastering this method of scaphoid fracture treatment.
Acute bilateral infarcts of the posterior inferior cerebellar artery

Acute bilateral infarcts in the territory of the posterior inferior cerebellum artery are rare and poorly documented in the literature. Thus, this report describes the clinical course and outcome in 3 patients. Although one was associated with coronary artery bypass surgery, the etiology was not known. Despite large territorial infarcts, the patients recovered to ambulation with minimal assistance.
DNA – Statistical Probability

The numerical strength of the evidence of matching DNA profiles is conveyed by a likelihood ratio. This is the probability under one hypothesis, generally from the Prosecution, divided by the probability of the evidence under an alternative hypothesis, generally from the Defense. The probabilities can be calculated to reflect the effects of population structure or of relatedness between individuals listed under the alternative hypotheses.
Induction of mortality and malformation in Xenopus laevis embryos by water sources associated with field frog deformities

Water samples from several ponds in Minnesota were evaluated for their capacity to induce malformations in embryos of Xenopus laevis. The FETAX assay was used to assess the occurrence of malformations following a 96-hr period of exposure to water samples. These studies were conducted following reports of high incidences of malformation in natural populations of frogs in Minnesota wetlands. The purpose of these studies was to determine if a biologically active agent(s) was present in the waters and could be detected using the FETAX assay. Water samples from ponds with high incidences of frog malformations (affected sites), along with water samples from ponds with unaffected frog populations (reference sites), were studied. Initial experiments clearly showed that water from affected sites induced mortality and malformation in Xenopus embryos, while water from reference sites had little or no effect. Induction of malformation was dose dependent and highly reproducible, both with stored samples and with samples taken at different times throughout the summer. The biological activity of the samples was reduced or eliminated when samples were passed through activated carbon. Limited evidence from these samples indicates that the causal factor(s) is not an infectious organism nor are ion concentrations or metals responsible for the effects observed. Results do indicate that the water matrix has a significant effect on the severity of toxicity. Based on the FETAX results and the occurrence of frog malformations observed in the field, these studies suggest that water in the affected sites contains one or more unknown agents that induce developmental abnormalities in Xenopus. These same factors may contribute to the increased incidence of malformation in native species.
Abstract TP24: Impact of Pretreatment With Intravenous Thrombolysis on Reperfusion Status in Emergent Large Vessel Occlusion (ELVO) Patients Treated With Mechanical Thrombectomy (MT)

Introduction: It currently remains unclear whether pre-treatment with intravenous thrombolysis (IVT) provides any additional benefits to emergent large vessel occlusion (ELVO) patients undergoing m...
Salivary Gland Tumors

The major and minor salivary glands give rise to a variety of both benign and malignant lesions. These disease entities are relatively rare, histologically diverse, and may involve several anatomically distinct sites. The goal of this chapter is to provide an overview of their clinical presentation and workup and summarize possible options in management.
187-OR: Gut Microbiota Regulate Pancreatic Growth, Exocrine Function, and Gut Hormones

Growing evidence suggests a link between alterations in gut microbiota, diabetes, and metabolic syndrome. We recently showed that treatment with antibiotics to alter gut microbiota could improve insulin signaling and glucose metabolism in obesity- and diabetes-prone C57BL/6J mice on high-fat diet (HFD). This occurred in part through changing metabolite composition in plasma and decreasing adipose tissue inflammation. We also showed that these changes could be induced in germ-free mice by transferring the gut microbiota. It is known that diabetes is associated with exocrine pancreatic dysfunction, and diseases of the exocrine pancreas can be associated with diabetes. To explore the role of gut microbiota on host pancreatic exocrine function and its crosstalk with the endocrine system, mice were given either normal chow or HFD, or HFD and treatment with vancomycin or metronidazole. As expected, HFD alone produced signs of metabolic syndrome but also increased total pancreas weight by ~20%, an amount that could not be explained by islet hyperplasia. Analysis of the fecal proteome of these mice identified 138 host proteins of which 32 changed with either HFD or antibiotic treatment. Notably, the most significantly changed proteins by diet and altered microbiome were pancreatic enzymes: amylase, lipase and elastase. Furthermore, the plasma levels of glucagon-like peptide-1 (GLP-1) and peptide YY (PYY) levels were decreased, while glucose-dependent insulinotropic peptide (GIP) was increased by the HFD. These alterations of pancreas growth, acinar cell hyperplasia, exocrine pancreas function, and hormone secretion were reversed by antibiotic treatment of the host. These changes could also be reproduced in germ free mice by transfer of gut microbiota. Together, these data indicate that gut microbiota can regulate pancreatic growth and both exocrine and endocrine function. Better understanding pancreas-gut microbiome crosstalk can help us develop probiotics to cure pancreas dysfunction in diabetes. Disclosure E. Altindis: None. M. Soto: Employee; Self; LNC Therapeutics. Other Relationship; Self; biomeostasis. L. Orliaguet: None. Q. Huang: None. C. Cederquist: None. E. Dirice: None. S. Fujisaka: None. J. Hu: None. R. Kulkarni: None. C. Kahn: Advisory Panel; Self; MedImmune. Board Member; Self; Kaleido Biosciences. Consultant; Self; AntriaBio, Inc., Cobalt Therapeutics, Flagship Pioneering. Research Support; Self; Alnylam. Funding National Institutes of Health
Periatrial Fat Quality Predicts Atrial Fibrillation Ablation Outcome

Background Previous studies showed that the quantity of the left atrial (LA) periatrial fat tissue predicts recurrence after catheter ablation of atrial fibrillation (AF). We hypothesized that the quality of the LA periatrial fat tissue, measured by the mean computed tomography attenuation, predicts recurrence after AF ablation independent of the quantity of the LA periatrial fat tissue. Methods We included 143 consecutive patients with drug-refractory AF referred for the first catheter ablation of AF (62.2±10 years, 40% nonparoxysmal AF). All participants had a preablation cardiac computed tomography. We measured the quantity of the LA periatrial fat tissue by the area (millimeter square) and the quality by the mean computed tomography attenuation (Hounsfield units) in a standard 4-chamber view. Results Patients with AF recurrence after ablation (n=57) had a significantly larger fat area (167.6 [interquartile range, 124.1-255] versus 145.4 [95.6-229.3] mm2; P=0.018) and a higher fat attenuation (-92.0±9.8 versus -96.5±9.4 Hounsfield units; P=0.006) than those without recurrence (controls). LA fat attenuation was correlated with LA fat volume and LA bipolar voltage by invasive mapping and was associated with AF recurrence after adjusting for clinical risk factors, including body mass index, AF type, LA dimension, and fat area (hazard ratio, 2.65; P=0.001). Conclusions The quality of the LA periatrial fat tissue is an independent predictor of recurrence after the first AF ablation. Assessment of LA periatrial fat attenuation can improve AF ablation outcomes by refining patient selection.
Bioactive Compounds of Georgian National Food: Determination of Antioxidant Activity

The diversity of the food in Georgia is directly connected with the ­biodiversity of the country consisting of 14 different soil climatic zones, beginning from subtropical and including steppe and alpine areas. The country is characterized by great amount of plants (the amount of endemic plants exceeds 1,100). Plants grown in the country contain hundreds of structurally different secondary metabolites the majority of which are characterized by definite physiological activity. Bioflavonoids, characterized by extremely high antioxidant activity, seem to be especially interesting. Other secondary metabolites presented in plants in high amount are: phenolics, organic and amino acids, vitamins of different groups, alkaloids, terpens, glycosides, etc. Antioxidant potential of Georgian wines and some Georgian food have been determined. All the food tested showed high antioxidant activity. Georgian wines (both red and white) produced by Kakhetian Technology are characterized by higher content of flavonoids and antioxidant activity than European type wines. The content of phenolic compounds and antioxidant activity is much higher in red wines than in whiter ones. On the base of Georgian flora ­biologically active biocomposites have been produced. These biocomposites show high antioxidant and antimicrobial activities. They are successfully used in food industry as biologically active food additives including food colorants.
An explicit van der Corput estimate for ζ(1/2+it)

Abstract An explicit estimate for the Riemann zeta function on the critical line is derived using the van der Corput method. An explicit van der Corput lemma is presented.
Online Appendix for 'Do Delays in Banks’ Loan Loss Provisioning Affect Economic Downturns? Evidence from the U.S. Housing Market'

This is an Online Appendix to "Do Delays in Banks' Loan Loss Provisioning Affect Economic Downturns? Evidence from the U.S. Housing Market", available at: https://ssrn.com/abstract=3395911.
Considerations for Modernized Criminal HIV Laws and Assessment of Legal Protections Against Release of Identified HIV Surveillance Data for Law Enforcement

In November 2018, the Centers for Disease Control and Prevention distributed guidance to funded agencies under its Integrated HIV Surveillance and Prevention Programs Initiative to support the impl...
Parity-Time-Symmetric Optics, Extraordinary Momentum and Spin in Evanescent Waves, Optical Analog of Topological Insulators, and the Quantum Spin Hall Effect of Light

This talk provides a brief and pedagogical overview to some aspects of parity-time-symmetric optics, extraordinary momentum and spin in evanescent waves, an optical analog of topological insulators, and the quantum spin Hall effect of light.