cssi/SciSciGPT-SciSciNet huggingface dataset:
Role of Cytoplasmic Tail of the Type 1A Angiotensin II Receptor in Agonist– and Phorbol Ester–Induced Desensitization

Abstract —To investigate mechanisms underlying the agonist-induced desensitization of the type 1A angiotensin II receptor (AT 1A -R), we have stably expressed in Chinese hamster ovary (CHO) cells the wild-type receptor and truncated mutants lacking varying lengths of the cytoplasmic tail. Assay of inositol 1,4,5-trisphosphate (IP 3 ) formation in response to agonist demonstrated that the truncated mutants T318, T328, and T348 lacking the last 42, 32, or 12 amino acid residues, respectively, couple with G q protein with an efficiency similar to that of full-length receptors, whereas coupling of G q protein was abolished in the T310 truncated mutant devoid of the carboxyl-terminal 50 amino acids. Exposure of CHO/AT 1A -R cells expressing the wild-type AT 1A -R to angiotensin II resulted in rapid and dose-dependent homologous desensitization of receptor-mediated IP 3 formation, which was independent of the receptor internalization. Mastoparan, an activator of G protein–coupled receptor kinase (GRK), induced desensitization of the AT 1A -R. The agonist-induced desensitization of the receptor was largely prevented by heparin, a potent inhibitor of GRK, whereas it was only partially attenuated by a protein kinase C (PKC)-specific inhibitor. The homologous or heterologous desensitization of the receptor was greatly impaired in the truncated mutants T318 and T328, lacking the Ser/Thr-rich (13 or 12 Ser/Thr residues) cytoplasmic tail of the AT 1A -R. Deletion of the last two Ser residues, including one PKC consensus site in the receptor tail, prevented only phorbol 12-myristate 13-acetate–induced desensitization by 30%. Moreover, we found an agonist-induced translocation of a heparin-sensitive kinase activity. The angiotensin II–stimulated heparin-sensitive kinase could phosphorylate a thioredoxin fusion protein containing the entire AT 1A -R cytoplasmic tail (N 295 to E 359 ), which lacks consensus phosphorylation sites for GRK1, GRK2, and GRK3. The heparin-sensitive kinase may not be GRK2, GRK3, or GRK6 expressed in CHO/AT 1A -R cells, since angiotensin II did not induce translocation of these receptor kinases. Potential Ser/Thr phosphorylation sites located between S 328 and S 347 in the cytoplasmic tail of AT 1A -R seem to play a critical role in the heterologous and homologous desensitization of the receptor. A heparin-sensitive kinase other than GRK2, GRK3, or GRK6 may be involved in the agonist-induced homologous desensitization of the AT 1A -R.
Immunologic monitoring of the cardiac transplant patient.

Peripheral blood lymphocyte morphology and cell surface markers were repeatedly evaluated in 49 orthotopic cardiac transplant patients over a period of three years to determine the utility of these parameters in predicting an episode of acute cardiac rejection. Lymphocytes were measured with a calibrated microscope and termed "activated" if greater than 10μ in diameter. If a patient demonstrated greater than 30 activated lymphocytes/cu mm, the same lymphocytes were stained with monoclonal antibodies directed to T-cell subsets and B cells. These findings were retrospectively correlated with endomyocardial biopsy results. Absolute numbers of T-cell subsets and B cells were analyzed via Student's t test to identify significant differences during acute cardiac rejection. Of 347 biopsy specimens, 47 demonstrated histologic features of acute cardiac rejection. Simultaneous immune activation of lymphocytes occurred with 33 of 47 samples, while another 51 episodes of lymphocyte activation were detected without acute rejection. No statistically significant differences in absolute numbers of T-lymphocyte subsets were noted at the time of acute rejection. (Chest 1988; 94:834-36)
Reducing DC-DC power

High efficiency DC-DC converter designs are vital for high efficiency power consumption. Designers of power supplies for battery driven products face the challenge of selecting the right integrated switched mode converter chips from an ever increasing number of vendors. Each vendor of course claims to offer the best solution for their application. Having selected the right product, the designer then has to make the right tradeoffs between certain design parameters. One of the most critical of these is the system's power consumption. Designing for the highest efficiency is therefore discussed in this article using the TPS6103x boost converter IC family from Texas Instruments as an example in the design of a power supply for a portable digital audio and video system.
The unfolding tale of the unfolded protein response

Surface and secreted proteins are synthesized in the endoplasmic reticulum where they must fold and assemble before being transported. Changes in the ER that interfere with their proper maturation initiate the unfolded protein response pathway. New studies have filled in a missing link between the yeast and mammalian pathways.
Estimating the out-of-band radiation flare levels for extreme ultraviolet lithography

For the commercialization of extreme ultraviolet lithography (EUVL), discharge or laser-produced, pulsed plasma light sources are being considered. These sources are known to emit into a broad range of wavelengths that are collectively referred to as out-of-band (OOB) radiation by lithographers. Multilayer EUV optics reflect OOB radiation emitted by the EUV sources onto the wafer plane, resulting in unwanted background exposure of the resist (flare) and reduced image contrast. The reflectivity of multilayer optics at the target wavelength of 13.5 nm is comparable to that of their reflectivity in the deep ultraviolet (DUV) and UV regions from 100 to 350 nm. The aromatic molecular backbones of many of the resists used for EUV are equally absorptive at specific DUV wavelengths as well. To study the effect of these wavelengths on imaging performance in a real system, we are in the process of integrating a DUV source into the Sematech Berkeley 0.3-NA microfield exposure tool (MET). We present the simulation-based imaging results predicting the potential impact of OOB based on known resist, mask, and multilayer conditions. It should be noted that because the projection optics work equally well as imaging optics at DUV wavelengths, OOB radiation cannot be treated simply as uniform background or DC flare.
Behavioral Differences of Invasive Container-Dwelling Mosquitoes to a Native Predator

Aquatic prey show behavioral modifications in the presence of predation-risk cues that alleviate their risk from predation. Aedes albopictus (Skuse), Aedes japonicus (Theobald), and Culex pipiens L. are invasive mosquitoes in North America, and their larvae are prey for the native mosquito predator, Toxorhynchites rutilus (Coquillett). Ae. albopictus and Ae. japonicus are recent invaders, whereas Cx. pipiens has been in the United States for >100 yr. In the presence of predation-risk cues from Tx. rutilus larvae, Cx. pipiens larvae increased the time spent resting at the surface (least risky behavior) more than the other prey species. Ae. japonicus larvae increased resting at the surface of the containers more than Ae. albopictus larvae in the presence of predation-risk cues. Cx. pipiens larvae spent more time motionless at the surface even in the absence of predation-risk cues when compared with the other species, indicating that Cx. pipiens larvae are the least vulnerable prey. As compared with the other prey species, Ae. albopictus larvae exhibited more high-risk behaviors both in the presence and absence of predation-risk cues, indicating that they are the most vulnerable prey. Ae. albopictus is the superior competitor; however, predation by Tx. rutilus larvae may prevent competitive exclusion by Ae. albopictus and promote coexistence among the three prey species.
A practical framework for demand-driven interprocedural data flow analysis

The high cost and growing importance of interprocedural data flow analysis have led to an increased interest in demand-driven algorithms. In this article, we present a general framework for developing demand-driven interprocedural data flow analyzers and report our experience in evaluating the performance of this approach. A demand for data flow information is modeled as a set of queries. The framework includes a generic demand-driven algorithm that determines the response to query by iteratively applying a system of query propagation rules. The propagation rules yield precise responses for the class of distributive finite data flow problems. We also describe a two-phase framework variation to accurately handle nondistributive problems. A performance evaluation of our demand-driven approach is presented for two data flow problems, namely, reaching-definitions and copy constant propagation. Our experiments show that demand-driven analysis performs well in practice, reducing both time and space requirements when compared with exhaustive analysis.
Works and representation

The concept of the “work” in art differs from and challenges traditional concepts of the “work” in bibliography. Whereas the traditional bibliographic concept of the work takes an ideational approach that incorporates mentalist epistemologies, container-content metaphors, and the conduit metaphor of information transfer and re-presentation, the concept of the work of art as is presented here begins with the site-specific and time-valued nature of the object as a product of human labor and as an event that is emergent through cultural forms and from social situations. The account of the work, here, is thus materialist and expressionist rather than ideational. This article takes the discussion of the work in the philosopher Martin Heidegger's philosophical-historical account and joins this with the concept of the work in the modern avant-garde, toward bringing into critique the traditional bibliographic conception of the work and toward illuminating a materialist perspective that may be useful in understanding cultural work-objects, as well as texts proper. © 2008 Wiley Periodicals, Inc.
Nightmare frequency in sexual assault survivors with PTSD.

Sexual assault survivors with post-traumatic stress disorder (PTSD) were assessed for frequency of nightmares, measured retrospectively on the Nightmare Frequency Questionnaire (NFQ) and prospectively on nightmare dream logs (NLOG). Retrospective frequency was extremely high, averaging occurrences every other night and an estimated number of nightmares greater than five per week. Test-retest reliability data on the NFQ yielded weighted kappa coefficients of .85 (95% CI, .74-.95) for nights and .90 (95% CI, .83-.97) for nightmares. Correlations between retrospective and prospective nightmare frequencies ranged between .53 (P = .001) for nights and .63 (P = .001) for nightmares. Correlations between frequency and distress measures (anxiety, depression, post-traumatic stress) yielded coefficients ranging from (r = .28-.53). Compared with intrusive, cumbersome and time-consuming prospective measurements, the NFQ appears reliable, convenient, and equally useful in assessing nightmare frequency in a group of sexual assault survivors. Nightmare frequency, prevalence, distress and impairment are discussed.
An in vivo arteriovenous malformation model in swine: preliminary feasibility and natural history study.

PURPOSE To assess the feasibility, natural history, and preliminary physiologic validation of creating an in vivo arteriovenous malformation model in swine. METHODS A transorbital puncture technique into the cavernous sinus was used to create an arteriovenous communication between the rostral rete and the cavernous sinus in eight swine. Short-term patency and hemodynamic behavior were assessed clinically and by serial angiography. Acute phase physiologic characterization of four models was also performed, using intravascular pressure and Doppler blood flow velocity measurements. RESULTS Large arteriovenous shunts between the rostral rete and cavernous sinus were consistently produced, which mimicked the angiographic features of cerebral arteriovenous malformations in humans. Classic changes in intraarterial and intravenous pressures and blood flow velocities were also observed. Early pathophysiologic evolution occurred in two animals, consisting of recruitment of previously unseen collateral vessels. Spontaneous occlusion of the arteriovenous shunt occurred in most animals within 7 days because of a rigorous fibroblastic response. CONCLUSIONS A simple technique for creating an arteriovenous malformation model in swine is now possible and is promising for future studies.
Some notes toward ethnographic responsibility and critique of contemporary communication theory 1

(1989). Some notes toward ethnographic responsibility and critique of contemporary communication theory. Research on Language and Social Interaction: Vol. 23, No. 1-4, pp. 283-291.
Studies to determine neutralizing antibody in sera from animals recovered from african swine fever and laboratory animals inoculated with african virus with adjuvants

1. Swine surviving inoculation with partially attenuated ASFV and subsequent inoculation with virulent challenge virus formed no demonstrable neutralizing antibody. 2. Inoculation of non-natural hosts to which ASFV is a foreign antigen, likewise, produced no demonstrable neutralizing antibody. Subsequent inoculation, however, of natural and non-natural hosts with FMDV resulted in formation of neutralizing antibody against this virus. 3. The absence of demonstrable neutralizing antibody in swine surviving challenge inoculation suggests that viral interference or development of tolerance was responsible for their refractory state.
Design optimization of a scramjet vehicle for ascent using surrogate optimization

Design optimization is performed for a scramjet-powered vehicle that ascends along a trajectory with constant dynamic pressure from Mach 7 to Mach 13. The net acceleration is free during the trajectory, and the optimum acceleration profile is dependent on the vehicle design. To perform this analysis, a new reduced-order model (MASIV) is used that can evaluate the forces and moments on the vehicle in about five seconds on a single computer while accounting for wave interactions, fuel-air mixing, finite-rate chemistry, and other complex physical phenomena. It is found that the optimum acceleration is close to the maximum acceleration that the vehicle can attain. To minimize the fuel consumed for the entire ascent trajectory, there is a trade-off between performance and robustness to variations in angle of attack.
Routine Laboratory Blood Tests May Diagnose Significant Fibrosis in Liver Transplant Recipients with Chronic Hepatitis C: A 10 Year Experience

Background and Aims: The aims of our study were to determine whether routine blood tests, the aspartate aminotransferase (AST) to Platelet Ratio Index (APRI) and Fibrosis 4 (Fib-4) scores, were associated with advanced fibrosis and to create a novel model in liver transplant recipients with chronic hepatitis C virus (HCV). Methods: We performed a cross sectional study of patients at The University of California at Los Angeles (UCLA) Medical Center who underwent liver transplantation for HCV. We used linear mixed effects models to analyze association between fibrosis severity and individual biochemical markers and mixed effects logistic regression to construct diagnostic models for advanced fibrosis (METAVIR F3-4). Cross-validation was used to estimate a receiving operator characteristic (ROC) curve for the prediction models and to estimate the area under the curve (AUC). Results: The mean (± standard deviation [SD]) age of our cohort was 55 (±7.7) years, and almost three quarter were male. The mean (±SD) time from transplant to liver biopsy was 19.9 (±17.1) months. The mean (±SD) APRI and Fib-4 scores were 3 (±12) and 7 (±14), respectively. Increased fibrosis was associated with lower platelet count and alanine aminotransferase (ALT) values and higher total bilirubin and Fib-4 scores. We developed a model that takes into account age, gender, platelet count, ALT, and total bilirubin, and this model outperformed APRI and Fib-4 with an AUC of 0.68 (p < 0.001). Conclusions: Our novel prediction model diagnosed the presence of advanced fibrosis more reliably than APRI and Fib-4 scores. This noninvasive calculation may be used clinically to identify liver transplant recipients with HCV with significant liver damage.
Oxygen Consumption by Diapausing and Nondiapausing Pupae of the Horn Fly

The horn fly, Haematobia irritans (L.), overwinters as pupae in diapause beneath manure pats in the soil (Hoelscher et al. 1967, Wright 1970). However, there is little information about the respiratory physiology of the overwintering horn fly pupa, although much information concerning the general biology of the horn fly is now available.
Tensile mechanical properties of collagen type I and its enzymatic crosslinks.

Abstract Collagen type I crosslink type and prevalence can be influenced by age, tissue type, and health; however, the role that crosslink chemical structure plays in mechanical behavior is not clear. Molecular dynamics simulations of ~65-nm-long microfibril units were used to predict how difunctional (deH-HLNL and HLKNL) and trifunctional (HHL and PYD) crosslinks respond to mechanical deformation. Low- and high-strain stress-strain regions were observed, corresponding to crosslink alignment. The high-strain elastic moduli were 37.7, 37.9, 39.9, and 42.4 GPa for the HLKNL, deH-HLNL, HHL, and PYD-crosslinked models, respectively. Bond dissociation analysis suggests that PYD is more brittle than HHL, with deH-HLNL and HLKNL being similarly ductile. These results agree with the tissues in which these crosslinks are found (e.g., deH-HLNL/HLKNL in developing tissues, HHL in mature skin, and PYD in mature bone). Chemical structure-function relationships identified for these crosslinks can aid the development of larger-scale models of collagenous tissues and materials.
Serial cerebrospinal fluid examinations to diagnose hematological malignancy causing neurological disease.

To determine the diagnostic utility of serial cerebrospinal fluid (CSF) examinations for hematological malignancy causing neurological disease. All CSF cytology reports at Mayo Clinic Rochester from 2005 to 2014 (n = 20,018) were reviewed. Study inclusion criteria were: repeated CSF examinations within 1 year in patients without known hematological malignancy performed to determine if hematological malignancy was the cause of neurological disease. Exclusion criteria were: preexisting hematological malignancy; >1 year between CSF examinations, serial CSF examinations for infection, tumor surveillance or intrathecal therapies, and for assessment or treatment of CSF dynamics (e.g. idiopathic intracranial hypertension, CSF shunt or persistent CSF leak). The initial study population included patients undergoing three or more serial CSF examinations; subsequently those undergoing two serial CSF examinations were investigated. A total of 613 patients met the study criteria with 477 having two CSF examinations and 136 having three or greater CSF examinations. Of those with three or greater serial CSF examinations none were found to have hematological malignancy exclusively on the third or subsequent CSF examinations. Of those with two CSF examinations 0.4 % (2/477) were found to have hematological malignancy (large B cell lymphomas) exclusively on the second CSF. Ten patients (1.6 %) had suspicious hematological abnormalities on initial CSF examinations confirmed on subsequent CSF examinations. Serial CSF examinations are of low yield to diagnose hematological malignancy as a cause of neurological disease but may confirm atypical features observed in an initial CSF examination.
Analysis of rotavirus G/P genotyping among children with diarrhea in Anhui province

Objective To study the characteristics of distribution of rotavirus G/P genotyping among children with diarrhea in Anhui province.Methods Total of 307 stool specimens were collected from hospitalized patients less than 5 years old with diarrhea from January to December 2011.Enzyme-linked immunosorbent assay(ELISA) was used to detect rotavirus antigen.Rotavirus-positive specimens were detected by reserve tanscription-polymerase chain reaction(RT-PCR) to determine the G and P genotypes of rotavirus.Results Of the 307 specimens,48 were detected to be positive.Genotyping of rotavirus showed that G3 was predominant strain(47.91%),followed by G9(27.08%),G1(16.67%),Gmix(14.58%),G2(6.25%) and G4(2.08%).P-genotyping showed that P[8] and P[4] was 62.67% and 8.33% respectively.The most common G/P combination identified was G3P[8].Conclusion Rotavirus G3P[8] was the predominant type of diarrhea among children in Anhui.G9 was the second predominant type and Gmix has been found in the region.
Donor–Acceptor Porous Conjugated Polymers for Photocatalytic Hydrogen Production: The Importance of Acceptor Comonomer

Porous conjugated polymer (PCP) is a new kind of photocatalyst for photocatalytic hydrogen production (PHP). Here, we report the importance of the electronic properties of acceptor comonomer in determining the reactivity of 4,8-di(thiophen-2-yl)benzo[1,2-b:4,5-b′]dithiophene (DBD)-based PCP photocatalyst for PHP application. It was found that the incorporation of nitrogen-containing ligand acceptor monomers into PCP network is an effective strategy to enhance the PHP activity. These moderately electron-deficient comonomers enhanced the dipole polarization effect. These PCPs exhibit appropriate solid-state morphology for charge transport. Powder X-ray diffraction (XRD) studies demonstrate that these PCP materials are semicrystalline materials. A strong correlation between the crystalline property and PHP activity is observed. The replacement of nitrogen-containing ligand acceptors with ligand-free strong acceptors is proved to be detrimental to the PHP process, indicating the proper choice in the electroni...
Social and Cultural Factors in Casework Diagnosis

The caseworker of today is highly skilled in knowing how to assess those personality determinants that are located in life expe riences specific to the individual. He rec ognizes emotional needs and deprivations as they arise from familial experiences; he is sensitive to the presence of anxiety and identifies the psychological mechanisms that the client uses to deal with his anxiety. The caseworker is able to take these fac tors into account because he has learned
Optimizing Parallel Clustering Throughput in Shared Memory

This article studies the optimization of parallel clustering throughput in the context of variant-based parallelism, which exploits commonalities and reuse among variant computations for multithreading scalability. This direction is motivated by challenging scientific applications where scientists have to execute multiple runs of clustering algorithms with different parameters to determine which ones best explain phenomena observed in empirical data. To make this process more efficient, we propose a novel set of optimizations to maximize the throughput of Density-Based Spatial Clustering of Applications with Noise (DBSCAN), a frequently used algorithm for scientific data mining in astronomy, geoscience, and many other fields. Our approach executes multiple algorithm variants in parallel, computes clusters concurrently, and leverages heuristics to maximize the reuse of results from completed variants. As scientific datasets continue to grow, maximizing clustering throughput with our techniques may accelerate the search and identification of natural phenomena of interest with computational support, i.e., Computer-Aided Discovery. We present evaluations on a whole spectrum of datasets, such as geoscience data on space weather phenomena, astronomical data from the Sloan Digital Sky Survey on intermediate-redshift galaxies, as well as synthetic datasets to characterize performance properties. Selected results show a 1,115 percent performance improvement due to indexing tailored for variant-based clustering, and a 2,209 percent performance improvement when applying all of our proposed optimizations.
Investigation of an adaptively-tuned digital non-Foster approach for impedance matching of electrically-small antennas

An adaptively-tuned digital non-Foster negative capacitor is investigated for impedance matching of electrically-small antennas. Such a digital non-Foster approach has the potential to address difficult design challenges such as stability and tolerance issues in analog non-Foster circuits. Furthermore, the digital non-Foster approach is tunable in software. The required negative capacitance is implemented using an ADC (analog-to-digital converter), DAC (digital-to-analog converter), and signal processing. In addition, the proposed adaptive approach uses the DAC and ADC to excite the antenna with a signal, and determine the antenna capacitance and resistance using impulse response and/or ARMA modeling. The digital non-Foster negative capacitance is then used to cancel the observed undesired reactance of the antenna. Results are given for an RC model of an electrically-short antenna that show effective estimation of impedance, and successful cancellation of most of the undesired reactance.
Security Measures Against a Rogue Network-on-Chip

Network-on-chip facilitates glueless interconnection of various on-chip components in the forthcoming system-on-chips. As in the case of any new technology, security is a major concern in network-on-chip (NoC) design too. In this work, we explore a covert threat model for multiprocessor system-on-chips (MPSoCs) stemming from the use of malicious third-party network-on-chips (NoCs). We illustrate that a rogue NoC (rNoC) can selectively disrupt the perceived availability of on-chip resources, thereby causing large performance bottlenecks for the applications running on the MPSoC platform. Further, to counter the threat posed by rNoC, we propose a runtime latency auditor that enables an MPSoC integrator to monitor the trustworthiness of the deployed NoC throughout the chip lifetime. We also discuss measures that can be taken to minimize the impact of a rNoC, once it is detected. Our comprehensive cross-layer analysis of our novel detection technique indicates modest overheads of 12.73% in area, 9.844% in power, and 5.4% in terms of network latency.
Dry, Preloaded NANOR ® -Type CF/LANR Components

Dry, preloaded NANOR ® -type technology makes LANR reactions more accessible. These self-contained, twoterminal nanocomposite ZrO 2 -PdNiD CF/LANR components have at their core ZrO 2 -PdD nanostructured material. The excess energy gain compared to driving input energy is up to 20 times the input; characterized by reasonable reproducibility and controllability. The CF/LANR/CF activation is separated from its loading. Although small in size, the LANR excess power density is more than 19,500 W/kg of nanostructured material, with zero carbon footprint.
A Bandwidth Guaranteed Integrated Routing Algorithm in IP over WDM Optical Networks

In this paper, we have developed an integrated online algorithm for dynamic routing of bandwidth guaranteed label switched paths (LSPs) in IP-over-WDM optical networks. Traditionally, routing at an upper layer (e.g., IP layer) is independent of wavelength routing at the optical layer. Wavelength routing at the optical layer sets up a quasi-static logical topology which is then used at the IP layer for IP routing. The coarse-grain wavelength channels and the pre-determined virtual topologies with respect to some a priori assumed traffic distribution are barriers to efficient resource use and inflexible to changing traffic. We take into account the combined knowledge of resource and topology information at both IP and optical layers. With this added knowledge, an integrated routing approach may extract better network efficiencies, be more robust to changing traffic patterns at the IP layer than schemes that either use dynamic routing information at the IP layer or use a static wavelength topology only. LSP set-up requests are represented in terms of a pair of ingress and egress routers as well as its bandwidth requirement, and arrive one-by-one. There is no a priori knowledge regarding the arrivals and characteristics of future LSP set-up requests. Our proposed algorithm considers not only the importance of critical links, but also their relative importance to routing potential future LSP set-up requests by characterizing their normalized bandwidth contribution to routing future LSP requests with bandwidth requirements. Moreover, link residual bandwidth information that captures the link's capability of routing future LSPs is also incorporated into route calculation. Extensive simulation was conducted to study the performance of our proposed algorithm and to compare it with some existing ones, such as the integrated minimum hop routing algorithm and the maximum open capacity routing algorithm. Simulation results show that our proposed algorithm performs better than both routing algorithms in terms of the number of LSP set-up requests rejected and the total available bandwidth between router pairs.
Short-term disability progression in two multiethnic multiple sclerosis centers in the treatment era.

Background:Short-term disease progression is well documented in clinical trials, but there are limited published data on disease course in real-life practice.Methods:Patient-derived Multiple Sclero...
'Uniting Our Voice at the Water’s Edge': Legislative Authority in the Cold War and Roosevelt Corollary

A central controversy of war powers today is whether, and under what conditions, the president may engage in war without legislative authorization. Congress’ authority over war met a profound challenge in the Korean War, commonly read as the “single most important precedent” for the displacement of Congress in the war powers system.1 Many see legislative acquiescence to Truman’s deployment of troops as a harbinger of a constitutional degradation, a turning point where fast-moving events, widespread fear, and opportunism created an unconstitutional shift in the balance of war authority towards the presidency.
Temperature and salinity sensitivity of respiration, grazing, and defecation rates in the estuarine eelgrass sea hare, Phyllaplysia taylori

Highly dynamic environments such as estuaries are home to organisms accustomed to wide fluctuations in environmental conditions. However, estuarine temperature and salinity conditions are expected to shift with climate change, potentially altering plant and animal physiology and consequently their ecological interactions. Phyllaplysia taylori, a sea hare that lives exclusively in nearshore eelgrass beds in the Eastern Pacific Ocean, is a positive ecological interactor with eelgrass by increasing eelgrass productivity through grazing removal of photosynthesis-blocking epiphytes. The central aim of our study is to understand how increasing temperature and salinity are likely to alter that ecological interaction. First, we determined salinity thresholds for survival of P. taylori at 20 °C (typical summer temperature) for 2 weeks, and found that significant mortality occurs at salinity below 25 ppt. Then, we determined respiration rate, grazing rate, and defecation rate of P. taylori following a crossed 2-week acclimation at typical summer low- and high temperatures (18 and 22 °C) and salinities (27 and 33 ppt). P. taylori respiration and grazing rates were elevated under low salinity and high temperature. To determine how P. taylori responds to very warm and extreme summer temperatures, we measured respiration rates at higher temperatures (26 °C—very warm summer and 30 °C—heat shock) and feeding rates following exposure to the 30 °C heat shock. Irrespective of acclimation salinity, P. taylori acclimated to 18 °C were more sensitive to heat shock, as they had a larger increase in respiration rate at 30 °C, and had reduced feeding rates following the 30 °C exposure, whereas there was no reduction in feeding rate in 22 °C acclimated specimens. This study provides the first data on the salinity and temperature sensitivity and metabolic physiology of P. taylori with relevance to their trophic position in the context of eelgrass ecosystems.
Surgeon Agreement on the Presence of Pathologic Anterior Instability on Shoulder Imaging Studies.

Background:In the setting of anterior shoulder instability, it is important to assess the reliability of orthopaedic surgeons to diagnose pathologic characteristics on the 2 most common imaging mod...
Biologics in refractory myositis: experience in juvenile vs. adult myositis; part II: emerging biologic and other therapies on the horizon.

The idiopathic inflammatory myopathies (IIM) until recently have been considered a heterogeneous broad group of six autoimmune muscle diseases. Initially, autoantibodies in IIM (including JDM) and CD8+ T cell-induced cytotoxicity (PM and IBM) were the predominant recognized etiopathology mechanisms used to classify myopathies. In the early late 1990’s to 2000’s, evolving understanding of the molecules such as interleukin (IL), tumor necrosis factor (TNF), interferon (IFN), and other cytokines as well as differences in response to therapies, has led IIM researchers to look beyond previous disease mechanisms. For decades the overexpression of Th1- associated cytokines (TNF-α, IFN-γ and IL-12) in the areas of inflammation in skin and muscle in IIM pointed to Th1 as the primary pathway for inflammation in myositis. However, in the last decade overexpression and elevated level of Th17-associated cytokines (IL-17, IL-22, and IL-6) were identified in the blood and the inflamed muscles of myositis patients. We also do not know how Th1 and Th2 cytokines work differently in diverse hosts, in different concentrations, in different inflammatory milieus, and in the presence or absence of each other or other adhesion/co-stimulatory molecules such as NF-κB. Also, several autoantibodies to intracellular organelles have been identified in myositis. In this review, we will discuss the most recent advances in IIM research and how that might bring new biologic therapies to market in the next 5–15 years to assist in the care of our most difficult IIM and JDM patients.
Development of parenting self-efficacy in mothers of high-risk infants.

Abstract Purpose The aim of this prospective, longitudinal study was to (1) examine the development of parenting self-efficacy (PSE), (2) explore the influence of contextual factors (e.g., family functioning, family centered care, and infant medical caregiving complexity) on PSE development, and (3) whether PSE and contextual factors predict parent and infant health outcomes in a high-risk infant population. Method Mothers (n = 67) of infants diagnosed with a complex medical condition following birth were enrolled within 3 weeks of their infant's diagnosis and admission to intensive care. Participants completed an online study survey at study enrollment (T1), infant discharge (T2), and 3 months after discharge (T3). Change in PSE was examined using mixed modeling and predictors of parent and infant health outcomes were explored using multiple regression. Results PSE significantly increased over time (b = 2.08, p Conclusion These are important findings given that PSE is known to contribute to infant development and health status.
Adaptive Epistemologies: Conceptualizing Adaptation to Climate Change in Environmental Science:

This article explores how scientists adapt to a changing climate. To do this, we bring examples from a case study of salmon habitat restorationists in the Columbia River Basin into conversation wit...
A case of platelet transfusion refractoriness due to anti-CD36 with a successful treatment outcome.

CONCLUSIONS Antibodies (Abs) against antigens on platelets (PLTs), including glycoprotein IV (CD36), can cause PLT refractoriness. Transfusing PLTs to patients with anti-CD36 is challenging because of the rarity of CD36-negative (CD36-) donors and the possibility of additional HLA Abs. We report a case of PLT refractoriness due to anti-CD36 and HLA Abs. A 21-year-old man (group O, D+) with assumed drug-induced aplastic anemia received multiple PLT transfusions and developed severe PLT refractoriness. He was found to have anti-CD36 as well as HLA class I Abs, with a CD36- phenotype on both PLTs and monocytes. He was diagnosed with type 1 CD36 deficiency and received intravenous immunoglobulin (IVIG) and rituximab to decrease future Ab production. The PLT corrected count increment (CCI) improved significantly with subsequent transfusions of flow crossmatchcompatible as well as uncrossmatched PLTs. He eventually received a bone marrow transplant and has been doing well since. The mean CCI before and after IVIG/rituximab treatment was 0.2 and 6.2, respectively. Soon after IVIG started, the patient's CCI after receiving CD36-, group AB, D+, and HLA untested PLTs was 0.8, but his CCI after receiving flow crossmatch-compatible PLTs was 12.6. Two months after IVIG was started, the mean CCIs for uncrossmatched apheresis PLTs and crossmatch-compatible PLTs were comparable (6.1 versus 6.0, respectively). Desensitization treatment with IVIG and rituximab lowered anti-CD36 and HLA Ab levels, and the CCI of PLT transfusion improved significantly. This case demonstrates that immune suppression is effective for successful PLT transfusion of patients with anti-CD36.
Behind the Hashtag: Online Disclosure of Mental Illness and Community Response on Tumblr

The present study examined personal disclosures about mental illness and the responses of online community members on the social media platform, Tumblr. We sampled public blog posts of 14,626 Tumblr users disclosing ten different mental health diagnoses using hashtags (e.g., #depression, #anxiety, and #anorexia). We examined the content of users' disclosures, predictors of disclosure frequency, and predictors of online community response. The content of most disclosures was related to users' emotions and cognitions about their mental health and their feelings of interpersonal loss and change over time. Content varied with users' disclosure frequency and with self-identified mental health diagnoses. Predictors of disclosure frequency included the "self effects" of writing about oneself or one's opinions, such as self-concept formation, and "reception effects" of receiving responses to one's writing. User disclosures generally increased with frequency of community response (reception effects), and the degree of this effect differed depending on the disclosed diagnosis (self effects). The responses of online community members also varied significantly across disclosed diagnoses. The implications of our findings for community research and action are discussed.
“Eating Ethics”: cooking up a storm, academically

Teaching about the ethical features of food and eating is perhaps best done through integrating experience and reflection. This article describes the evolution of one course that has students devel...
Modeling Nuclear Data Uncertainties Using Deep Neural Networks

A new concept using deep learning in neural networks is investigated to characterize the underlying uncertainty of nuclear data. Analysis is performed on multi-group neutron cross-sections (56 energy groups) for the GODIVA U-235 sphere. A deep model is trained with cross-validation using 1000 nuclear data random samples to fit 336 nuclear data parameters. Although of the very limited sample size (1000 samples) available in this study, the trained models demonstrate promising performance, where a prediction error of about 166 pcm is found for keff in the test set. In addition, the deep model’s sensitivity and uncertainty are validated. The comparison of importance ranking of the principal fast fission energy groups with adjoint methods shows fair agreement, while a very good agreement is observed when comparing the global keff uncertainty with sampling methods. The findings of this work shall motivate additional efforts on using machine learning to unravel complexities in nuclear data research.
A Unique Cause of Elbow Pain And Loss Of Range Of Motion In A 13-Year-Old

A 13-year-old right hand dominant young lady presented to a pediatric sports medicine clinic for evaluation of decreased ROM and pain in her left elbow with an associated locking sensation that had been occurring for over a year. Two weeks prior to presentation, these symptoms had been acutely worsening as she was practicing for over 10 hours per day for an upcoming dance competition. The patient’s pain is described as a “tightness” and is localized to her antecubital fossa medial to her biceps tendon. The feeling of tightness occurs most prominently with end extension and flexion of the elbow. She has had no associated fever, chills, fatigue, weight loss, …
A confinable home and rescue gene drive for population modification

Homing-based gene drives, engineered using CRISPR/Cas9, have been proposed to spread desirable genes throughout populations. However, invasion of such drives can be hindered by the accumulation of resistant alleles. To limit this obstacle, we engineer a confinable population modification home-and-rescue (HomeR) drive in Drosophila targeting an essential gene. In our experiments, resistant alleles that disrupt the target gene function were recessive lethal and therefore disadvantaged. We demonstrate that HomeR can achieve an increase in frequency in population cage experiments, but that fitness costs due to the Cas9 insertion limit drive efficacy. Finally, we conduct mathematical modeling comparing HomeR to contemporary gene drive architectures for population modification over wide ranges of fitness costs, transmission rates, and release regimens. HomeR could potentially be adapted to other species, as a means for safe, confinable, modification of wild populations.
Social Network Analysis of Male Dominance in the Paper Wasp Mischocyttarus mastigophorus (Hymenoptera: Vespidae)

Social aggression is a pervasive feature of insect societies. In eusocial Hymenoptera, aggression among females can affect task performance and competition over direct reproduction (egg laying); in most species males participate in social interactions relatively rarely. Males of the independent-founding paper wasp Mischocyttarus mastigophorus are exceptional: they are aggressive toward female nestmates, leading us to explore the function of this unusual behavior. We applied social network analyses to data on M. mastigophorus social aggression to quantify sex differences in giving and receiving social aggression. The network analyses supported the pattern of biased male aggression toward female nestmates; females are relatively rarely aggressive to males. We then asked whether male aggression toward females was biased by females’ relative ovary development. Males were more aggressive toward females with better-developed ovaries, opposite to patterns of aggression among females. Because food brought to the colonies is often monopolized by dominant females, we suggest that males direct aggression toward socially dominant females with better-developed ovaries to obtain food. The implications of biased male aggression for female task performance and physiology are unknown.
Online Noise as Illustrated by Pitfalls and Biogeography Associated With Common Names for Puma concolor

Noise is the non-target search results that people encounter when searching for a particular topic of interest; conversely, it is the cloud of distracting data that can obscure or deflect conservation communication. Online noise associated with large carnivores is particularly dense because their defining characteristics make them salient. Mountain lions (Puma concolor) exemplify noise associated with multiple vernaculars for a species in the crosshairs of conservation conundrums. We compared internet search results, Google Trends reflecting topic interest, use in science publications and sentiment in print and online media for P. concolor’s most frequent vernacular names, “mountain lion,” “cougar,” “puma” and “Florida panther.” Puma and panther exhibited greater noise and salience than cougar or mountain lion, but, results for mountain lion, followed by cougar, yielded the highest biological relevance. Online sentiment negatively correlated with biological relevance, with positive sentiment highest for the noisiest vernaculars, puma and panther. As conservation practitioners, we must recognize that public outreach is part of our scientific agenda and be conscious of crafting communication that reaches and resonates with our intended audiences.
The Implications of Legistlative Power: State Constitutions, State Legislatures, and Mid-Decade Redistricting

In the wake of the U.S. Supreme Court's splintered decision in 2006 in League of United Latin American Citizens vc Perry, future federal constitutional challenges to mid-decade redistricting appear to be dead on arrival. Yet, experience demonstrates that state constitutions may provide a viable alternative source for meaningful limits on the ability of states to engage in mid-decade redistricting. Indeed, in combination with constitutional language indicating the time at which redistricting should occur, the plenary nature of state legislative power compels the conclusion that state legislatures generally lack the power to engage in mid-decade redistricting. Many state supreme courts, including those of South Dakota and Colorado, have already reached this conclusion. This Note contends that other state courts should similarly interpret their constitutions to require redistricting after the national census and before the ensuing general election, and to prohibit redistricting at any other time.
Acceptance and perception of digital health for managing nutrition in people with Parkinson's disease and their caregivers and their digital competence in the United States: A mixed-methods study.

Background and aims This mixed-methods study examined participants' acceptance and perception of using digital health for managing nutrition and participants' digital competence. The results will be formative for making digital nutrition education more effective and acceptable for people with Parkinson's disease (PwPD) and their informal caregivers. Methods Qualitative data were collected through in-person semi-structured, dyadic interviews, and questionnaires from 20 dyads (20 PwPD and their caregivers) in the Northeastern United States and analyzed throughout the 2018 to 2019 academic year. Interview transcripts were deductively coded using the framework analysis method. Phrases related to acceptance of digital health were sub-coded into accept, neutral, or reject and those related to perceptions of digital health were sub-coded into perceived usefulness, perceived ease of use, and awareness of digital health. Quantitative data were analyzed using independent samples t tests and Fisher's exact tests. Qualitative codes were transformed into variables and compared to digital competence scores to integrate the data. An average acceptance rate for digital health was calculated through examining the mean percent of phrases coded as accept from interview transcripts. Results Twenty-five of 40 (62.5%) participants used the internet for at least 5 health-related purposes and the average acceptance rate was 54.4%. Dyads rejected digital health devices if they did not see the added benefit. The majority of participants reported digital health to be useful, but hard to use, and about half felt they needed education about existing digital health platforms. There was no difference in digital competence scores between PwPD and their caregivers (28.6 ± 12.6). Conclusion Findings suggest that dyads accept and use technology but not to its full potential as technology can be perceived as hard to use. This finding, combined with digital competence scores, revealed that education is warranted prior to providing a digital nutrition intervention.