cssi/SciSciGPT-SciSciNet huggingface dataset:
A global data management strategy for distributed computing systems

We have presented a global data management strategy for a logic storage space based on storage devices that. are attached to computing systems that may be locally or remotely interconnected via a network. We discussed the functional chwacteristics and capabilities of the strategy vis a vis the current techniques. The processes for the creation, configuration, making file systems, accessing data, extension, and reduction of an Allocatzon Space Area Devzce (ASAD) are described.
Effects of cancer on spermatozoa quality after cryopreservation: a 12-year experience

Objective To determine whether type of cancer and response to treatment was related to prefreeze or post-thaw semen quality and to predict post-thaw sperm motility from prefreeze motility. Design Retrospective study. Setting Tertiary care institution. Patient(s) One hundred six cancer patients cryopreserving their semen specimens. Intervention(s) Computer-assisted semen analysis was performed before and after cryopreservation on each patient specimen. Main Outcome Measure(s) The relationship of sperm motility and motion characteristics to type of cancer and patient's response to treatment. Result(s) Prefreeze and post-thaw semen quality did not differ between patients presenting with testicular cancer and Hodgkin's disease. Patients with leukemia or advanced soft tissue cancer had a higher prefreeze and post-thaw motility and higher total and motile sperm count than testicular and Hodgkin's disease patients. A prefreeze sperm motility of ≥ 15% could predict a post-thaw motility of >10%. Conclusion(s) Prefreeze or post-thaw semen quality in cancer patients is not affected (except the prefreeze motile sperm count within the testicular cancer patients) by the type of disease. Prefreeze motility can predict post-thaw motility. Cryopreservation of semen should be offered to cancer patients irrespective of the type of disease. Fertil Steril® 1997;67:326-31
KNACK Online: an evidence-based Web site developed to address adolescent obesity.

Department of Human Nutrition, Kansas State University, Manhattan, Kansas School of Family Studies and Human Services, Kansas State University, Manhattan, Kansas Corresponding author: Tandalayo Kidd, PhD, RD, LPN, Assistant Professor and Extension Specialist, Kansas State University, Department of Human Nutrition, 203 Justin Hall, Manhattan, KS 66506-1407; Phone: (785) 532-0154; Fax: (785) 532-1678; E-mail: martan@ksu.edu doi: 10.1016/j.jneb.2007.05.006
How to Image Cardiac Amyloidosis

A 74-year-old man presented with decreasing exercise tolerance and mild ankle edema. He was previously fit but was now breathless on climbing 2 flights of stairs. He had no history of angina, orthopnea, or paroxysmal nocturnal dyspnea. His medical history included non–insulin-dependent diabetes mellitus treated for 10 years and mild hypertension. Six years earlier he had been diagnosed with a monoclonal gammopathy of unknown significance. At that time, a bone marrow biopsy showed 30% overall cellularity with 5% to 10% plasmacytosis (normal <4%) and immunoglobulin light-chain restriction. Approximately 3 years ago, he developed deep vein thrombosis and was treated with low-molecular-weight heparin. A year later, leg swelling occurred and was attributed to venous insufficiency. The following year, he developed progressive fatigue on exertion, and an abnormal ECG (Figure 1) led to a treadmill test that was considered normal. An echocardiogram showed concentric wall thickening (Movie 1 in the Data Supplement), and the possibility of cardiac amyloidosis was raised. A fat pad biopsy was negative for amyloid deposits. The bone marrow biopsy performed in 2005 (when his monoclonal gammopathy of unknown significance was diagnosed) was restained and was negative for amyloid. At that time, serum-free λ light chains were 108.9 mg/L (normal range, 5.7–26.3) with κ light chains of 13 mg/L (normal, 3.3–19) and an abnormal ratio of 0.12 (normal, 0.26–1.65). His brain natriuretic peptide measured 275 pcg/mL. He was treated with oral diuretics, which improved leg swelling, but because of persistent symptoms, he sought medical care at our institution. On review of symptoms, he denied jaw claudication, symptoms of postural hypotension, easy bruising, or tongue swelling. He did give a history suggestive of neuropathy with a leathery feeling in his feet but no numbness in his hands. Medications included metformin 500 mg twice a day, aspirin 80 mg daily, lisinopril …
Synthesis and cyclopolymerization of 4,4‐dimethyl‐1,6‐heptadiene‐3,5‐dione

Dimethyldiacrylylmethane has been synthesized and polymerized to yield a soluble polymer which has the cyclic 1,3-diketone structure. It has not been possible to prepare a polydioxime of this polyketone, but a monooxime with only 90% oximated structure was obtained. This monooxime underwent the Knoevenagel reaction to yield a partial ladder polymer which had interesting thermal stability.
Mass size distributions and size resolved chemical composition of fine particulate matter at the Pittsburgh supersite

Size-resolved aerosol mass and chemical composition were measured during the Pittsburgh Air Quality Study. Daily samples were collected for 12 months from July 2001 to June 2002. Micro-orifice uniform deposit impactors (MOUDIs) were used to collect aerosol samples offine particulate matter smaller than 10 mm. Measurements ofPM 0.056 ,P M 0.10, PM0.18 ,P M 0.32 ,P M 0.56 ,P M 1.0 ,P M 1.8 and PM2.5 with the MOUDI are available for the full study period. Seasonal variations in the concentrations are observed for all size cuts. Higher concentrations are observed during the summer and lower during the winter. Comparison between the PM2.5 measurements by the MOUDI and other integrated PM samplers reveals good agreement. Good correlation is observed for PM10 between the MOUDI and an integrated sampler but the MOUDI underestimates PM10 by 20%. Bouncing ofparticles f rom higher stages ofthe MOUDI (>PM 2.5) is not a major problem because ofthe low concentrations ofcoarse particles in the area. The main cause ofcoarse particle losses appears to be losses to the wall ofthe MOUDI. Samples were collected on aluminum foils for analysis of carbonaceous material and on Teflon filters for analysis of particle mass and inorganic anions and cations. Daily samples were analyzed during the summer (July 2001) and the winter intensives (January 2002). During the summer around 50% ofthe organic material is lost f the aluminum foils as compared to a filter-based sampler. These losses are due to volatilization and bounce-off from the MOUDI stages. High nitrate losses from the MOUDI are also observed during the summer (above 70%). Good agreement between the gravimetrically determined mass and the sum ofthe masses ofthe individual compounds is obtained, ifthe lost mass from organics and the aerosol water content are included for the summer. For the winter no significant losses ofmaterial are detected and there exists reasonable agreement between the gravimetrical mass and the sum ofthe concentrations ofthe individual compounds. Ultrafine particles (below 100 nm) account on average, for o 5% ofthe PM 2.5 mass, and show different composition for the summer and the winter. During the summer the ultrafine mass is 50% carbonaceous material (organic material and elemental carbon) and 50% inorganic (mainly sulfate and ammonium); during the winter these percentages are 70% and 30%, respectively. r 2004 Elsevier Ltd. All rights reserved.
Measurement of order-disorder transitions in biological samples using polarization-modulated second harmonic generation imaging

Transitions in order/disorder phase states of biological tissues were analyzed using polarization modulated second harmonic generation imaging. The degree of structural disorder was significantly correlated with severity of pathological changes.
Technological Pedagogical Content Knowledge in the Mathematics Classroom.

AbstractTeacher knowledge has long been a focus of many educational researchers. Current conceptualizations of teacher knowledge are beginning to reflect the knowledge and skills teachers need to successfully navigate increasingly technologically-rich mathematical classrooms with the addition of knowledge domains such as technological pedagogical content knowledge (TPACK). This article situates TPACK in the mathematics classroom by developing four central components of knowledge necessary for technology using mathematics teachers. This article concludes by presenting a portrait of effective TPACK in action and posing questions for technology-using teachers to consider as they embark on technology use in support of mathematics instruction. The intent of this article is not to offer a one-size-fits-all solution to the many issues surrounding technology use, but to provide the impetus for discussion and reflection among mathematics educators at all levels.
Sudden death from acute thromboembolic occlusion of the left coronary ostium.

Abstract The patient was a 55-year-old woman who experienced anterior chest pain after drinking a cup of coffee. The patient had no risk factor for cardiac disease other than mild non- insulin-dependent diabetes mellitus. The patient did have a history of asthma and was on a steroid taper, taking 20 mg of prednisone daily. The patient's physical examination results were within normal limits. Her laboratory data were normal, except for a glucose level of 499 mg/dl and a urinalysis revealing more than 4+ glucose with large ketones. Venous blood gas pH was 7.36, and troponin I, creatinine kinase-MB, electrocardiogram, and chest film were normal. The patient was admitted to rule out acute coronary syndrome. During the placement into an inpatient bed, the patient sustained a cardiac arrest with a narrow complex ventricular rhythm without pulse, from which she could not be resuscitated. The postmortem examination of the lungs revealed no evidence of thromboemboli. The coronary arteries revealed mild atherosclerosis. Examination of the aortic root revealed complete occlusion of the left coronary ostium by a large premortem nonorganized fresh thromboembolus, which was easily removed by passing a probe retrograde from the left main coronary artery (Fig. 1). Microscopically, there were also small thromboemboli in both the distal right and left coronary intramyocardial vessels. An extensive search of the heart and all major vessels was undertaken to identify the source of the possible thromboemboli, and none could be identified. A Medline search of the literature revealed no other similar case.
Application of the collective approach to the thermodynamics of an electron gas

Collective approach to thermodynamics of N- particle electron gas including transverse radiation, calculating internal energy and pressure of modes
The Multiple Roles of Cohesin in Meiotic Chromosome Morphogenesis and Pairing

Sister chromatid cohesion, mediated by cohesin complexes, is laid down during DNA replication and is essential for the accurate segregation of chromosomes. Previous studies indicated that, in addition to their cohesion function, cohesins are essential for completion of recombination, pairing, meiotic chromosome axis formation, and assembly of the synaptonemal complex (SC). Using mutants in the cohesin subunit Rec8, in which phosphorylated residues were mutated to alanines, we show that cohesin phosphorylation is not only important for cohesin removal, but that cohesin's meiotic prophase functions are distinct from each other. We find pairing and SC formation to be dependent on Rec8, but independent of the presence of a sister chromatid and hence sister chromatid cohesion. We identified mutations in REC8 that differentially affect Rec8's cohesion, pairing, recombination, chromosome axis and SC assembly function. These findings define Rec8 as a key determinant of meiotic chromosome morphogenesis and a central player in multiple meiotic events.
Determination of the structural anisotropy in amorphous Tb-Fe films

The authors report the measurement and description of an anisotropy between the in-plane and out-of-plane atomic structure in as-deposited amorphous Tb-Fe alloy films. This anisotropy, measured using a conversion-electron extended X-ray absorption fine structure (EXAFS) technique, correlates closely with measured values of the perpendicular magnetic anisotropy energy as a function of both film composition and annealing temperature. Modeling of the EXAFS data using theoretical codes and structural standards suggests that the Tb-Tb and Fe-Fe pair correlations are greater parallel to the film plane and that the Tb-Fe pair correlations are greater perpendicular to the film plane. Upon annealing at 300 degrees C the structural anisotropy is eliminated, and the magnetic anisotropy is lowered to a level consistent with magnetoelastic interactions between the film and substrate. >
New method for producing high-performance thermoplastic polymeric foams

A new method for the production of foamed thermoplastic polymers from blends of a poly(aryl ether ketone) (PAEK) and polyetherimide (PEI) is presented. The blowing agent for the foaming process is water which is produced at elevated temperatures in an extruder, via an in situ reaction between an amine end group on the PEI, and a ketone functionality on the backbone of the PAEK chain. The effect of composition, mixing, time, and temperature are investigated. © 1997 John Wiley & Sons, Inc. J Appl Polym Sci 66: 1543–1550, 1997
Business process improvement using ebXML

EbXML is an end-to-end B2B XML framework that provides concrete specifications for dynamic B2B collaborations. EbXML has established itself as a global standard for electronic business enabling anyone, especially small and medium-size enterprises, anywhere to do business with anyone else over the Internet. It is complementary to other existing B2B initiatives; those from both business sphere (RosettaNet, TradeXchange, etc.) and from software developer community (e.g. UDDI, SOAP). Strength of ebXML lies in the fact that it arose from the direct involvement of various user groups working to solve a specific problem rather than from technology companies trying to solve a general problem and making a best guess at some standards on behalf of users.
SIMULTANEOUS RECOVERY AND DETECTION OF FOUR HEAT‐INJURED FOODBORNE PATHOGENS IN GROUND BEEF AND MILK BY A FOUR‐COMPARTMENT THIN AGAR LAYER PLATE

A four-compartment thin agar layer (4-TAL) system was developed to improve operation efficiency and recover injured foodborne pathogens simultaneously. The system consisted of a layer of nonselective agar overlaid on four different selective agars (xylose lysine desoxycholate [XLD], cefsulodin irgasan novobiocin [CIN], modified Oxford medium [MOX] and MacConkey sorbitol agar [MSA]) housed in a four-compartment petri dish. We applied this system to simultaneously recover heat-injured (55C, 10 min) Escherichia coli O157:H7 (MSA), Listeria monocytogenes (MOX), Salmonella Typhimurium (XLD) and Yersinia enterocolitica (CIN) from ground beef and pasteurized milk. No significant difference (P > 0.05) occurred between the single recovery unit (nonselective agar overlaid on one selective agar in a standard petri dish) and the 4-TAL for detecting four heat-injured pathogens in tested samples. Both TAL methods showed greater recovery of four heat-injured pathogens than the pathogen-specific selective media (P < 0.05). The 4-TAL system appears to be efficient for recovery and detection of injured pathogens in food in terms of operation, material and labor costs, and space of incubation.
On the boundedness of bilinear operators on products of Besov and Lebesgue spaces

Abstract We prove mapping properties of the form T : B ˙ p 1 α 1 , q 1 × L p 2 → B ˙ p 3 α 2 , q 2 and T : B ˙ p 1 α 1 , q 1 × B ˙ p 2 α 2 , q 2 → L p 3 , for certain related indices p 1 , p 2 , p 3 , q 1 , q 2 , α 1 , α 2 ∈ R , where T is a bilinear Hormander–Mihlin multiplier or a molecular paraproduct. Applications to bilinear Littlewood–Paley theory are discussed.
An examination of the municipal 311 system

Government accountability and responsiveness are foundational concerns of public managers, citizens, the media, and advocacy organizations. Technologies provide viable alternatives for increasing citizen access to government and improving governmentʼs responses to the issues of greatest concern to citizens, and the implementation of non-emergency 311 systems have shown tremendous potential in this regard. This paper, therefore, examines municipal 311 systems in terms of accountability and responsiveness functions, namely usability, services provided, internal operations, and measurable outputs. A survey of fourteen municipalities with 311 systems throughout the United States results in the identification of best practices in each of the four research categories.
The history of English law : centenary essays on 'Pollock and Maitland'

Pollock and Maitland's classic The History of English Law before the time of Edward I is perhaps unique amongst late Victorian historical works in remaining the fundamental text on its subject a hundred years later. The current volume gathers leading legal historians to celebrate Maitland's achievement, to analyse his methods, to assess his legacy, and to suggest new directions for research into the history of English law before the reign of Edward I.
Python Programming 101

This first chapter introduces Python to readers that have never programmed in Python before. It also provides instructions for installing Python on your computer. The Wing Integrated Development Environment (IDE) is recommended for students learning to program. Wing IDE 101 is the free version of the IDE for educational use. The chapter goes on to introduce classes, objects, and object-oriented programming by developing a drawing application using the Tkinter graphical user interface library. An understanding of object-oriented programming concepts presented in this chapter is necessary before reading the rest of the text. The PyList datatype presented in this chapter is also used in subsequent chapters including Chap. 2. Even if the reader has worked through an introductory text or has a basic understanding of Python, there are concepts from this first chapter that are used throughout the text.
A rational approach to the surgical needs of the cerebral palsy patient.

This paper, as stated in the introduction, is presented to redirect attention to a primary orthopaedic problem; to describe techniques to correct triceps surae dysfunction; to emphasize the importance of correcting deformities caused by spasticity or tension in the tensor fasciae latae; to point out deformities in the foot which can be corrected and controlled by the Grice bone block; and to emphasize the importance of correcting all deformities before instituting rehabilitation in the cerebral palsy patient. The examination of 977 cerebral palsy patients at the North Carolina Cerebral Palsy Hospital and an uncalculated number in associated clinics from February 1950 to May 1954 has afforded an opportunity to evaluate many cerebral palsy problems. The opinions expressed are based on the results seen following 590 operative procedures carried out in 186 patients. The type of surgery performed is shown in Table II. With the present widespread and professional lay interest in cerebral palsy, it is hoped that these and other well established orthopaedic surgical procedures can be used to the benefit of the cerebral palsy patient, and that new procedures will be developed that will further advance surgery in this difficult field.
Human FGF-21 Is a Substrate of Fibroblast Activation Protein

FGF-21 is a key regulator of metabolism and potential drug candidate for the treatment of type II diabetes and other metabolic disorders. However, the half-life of active, circulating, human FGF-21 has recently been shown to be limited in mice and monkeys by a proteolytic cleavage between P171 and S172. Here, we show that fibroblast activation protein is the enzyme responsible for this proteolysis by demonstrating that purified FAP cleaves human FGF-21 at this site in vitro, and that an FAP-specific inhibitor, ARI-3099, blocks the activity in mouse, monkey and human plasma and prolongs the half-life of circulating human FGF-21 in mice. Mouse FGF-21, however, lacks the FAP cleavage site and is not cleaved by FAP. These findings indicate FAP may function in the regulation of metabolism and that FAP inhibitors may prove useful in the treatment of diabetes and metabolic disorders in humans, but pre-clinical proof of concept studies in rodents will be problematic.
Inter-species comparisons of variation in magnitude of inhibitory control in reversal learning.

Comparison of successive discrimination reversal (SDR) performances of a number of avian and mammalian species has increasingly suggested that SDR methodology yields inter-species differences of taxonomic and phyler~c Import. Perhaps the most promising hypothesis advanced to account for such differences has been thar of Krushinskii (1962) who suggests that such differences will arise because phyletically disparate species will differ in their capacity to inhibit previously correct, reinforceable responses, and not in their capacity to learn new, reinforceable responses. An initial test of this hypothesis can be provided by SDR dara already obtained in our laboratory, by comparing initial error data across successive reversal problems for phylerically disparate species. Initial error measures, defined as the number of incorrect responses following a reversal prior to the first correct response, are abbreviated measures of resistance to extinction. Thus, they can be viewed as reflecting the development of inhibitory control. Data from 3 species of Galliformes, pigeons, and Himalayan Magpies, representing respectively lower and higher avian species, as well as data from Squirrel and Capuchin monkeys were analyzed. All dara were obtained from a spatial SDR task, previously described (Gosserte & Cohen, 1966; Gossette & Inman, 1966). Table 1 presents mean initial error data across 20 problems for the 7 species. Analysis by Kcuskal-Wallis test showed that the primate performance was superior ( p < ,001) to
Notes on Behavior and Colonization of Buenoa scimitra (Hemiptera: Notonectidae), a Predator of Mosquito Larvae

Buenoa scimitra Bare is a common backswimmer in freshwater pools in Mexico and southern United States (Truxal 1953). Bare (1926) gave information on life history. Because B. scimitra preys upon mosquito larvae, information on its culture and habits is relevant to its possible use as a biological control of mosquitoes.
An Apparatus for Testing Visual Discrimination in Animals

* Accepted for publication by Walter S. Hunter of the Editorial Board and received in the Editorial Office, September 22, 1930.
A demonstration of 1–2 parts in 10 7 accuracy using GPS

By interferometric analysis ofGPS phase observations made at Owens Valley, Mojave, and Mammoth Lakes, California, we determined the coordinate components of the71–245–313 km triangle of baselines connecting these sites. A separate determination was made on each of four days, April 1–4, 1985. The satellite ephemerides used in these determinations had been derived from observations on other baselines. Therms scatters of the four daily determinations of baseline vector components about their respective means ranged from a minimum of6 mm for the north component of the71-km baseline to a maximum of34 mm for the vertical component of the245-km baseline. To test accuracy, we compared the mean of ourGPS determinations of the245-km baseline between Owens Valley and Mojave with independent determinations by others using very-long-baseline interferometry(VLBI) and satellite laser ranging(SLR). TheGPS-VLBI difference was within 2 parts in10 7 for every vector component. TheGPS-SLR difference was within6 parts in10 8 in the horizontal coordinates, but83 mm in height.
Techniques for the thermal evaluation of transformer insulation systems

A unique test method for screening transformer insulation systems was presented in a paper (1) during the 1962 Electrical Insulation Conference. This test method referred to as "Progressive Temperature Testing" was based on increasing the test temperature in finite steps until the insulation system fails. The test temperatures and times were selected in accordance with the Arrhenius(2) relationship of the logarithm of life and the reciprocal of absolute temperature.
Inhibition Effect of Ethanol Extract of Berberis Amurensis on S_(180) Sarcoma of Mouse

[Objective]To investigate the inhibition effect of ethanol extract of Berberis amurensis on S-180 sarcoma of mouse.[Methods]S-180 sarcoma cell was transplanted to the mouse according to the standard approach and different dosages of enhanol extract of Berberis amurensis were given by intragastric administration after randomized grouping.After 10 days,the effect on anti-tumor rate,mass fraction of immune organs,spleen body ratio,body weight change and other indexes were observed.[Results]The inhibition rates of different doses of enhanol extract of Berberis amurensis on S-180 sarcoma cell were 19.00%,33.00%,46.05 %;The inhibition effects of large,medium and small doses groups were not significantly different with that of tumor-bearing control group;the body weight of large dose group was significantly different with that of tumor-bearing control group;the differences between other groups were not significant.[Conclusion]The ethanol extract of Berberis amurensis has inhibition effect on S-180 sarcoma of mouse.
Use of Fourier Spectra for Ultrasonic Nondestructive Evaluation of Thin Coatings

There is clearly a need for a simple, reliable and inexpensive nondestructive technique for characterizing thin coatings;1 by thin we mean the thickness of the coating is less than the wavelength of the ultrasonic wave used to interrogate it. We have developed a technique for a simultaneous measurement of both thickness (h) and wavespeed (c) for thin coatings using transducers with a center-frequency of 10 or 20 MHz. Transfer functions have been derived. A systematic analysis of the sensitivity of the transfer functions to the coating properties has been carried out. This technique is independent of the substrate thickness. The technique was used to characterize epoxy or Plexiglas coatings (50-100 µm) on an aluminum substrate. The precision in the measurement of the thickness and wavespeed was found to be ±2 µm and ±3%, respectively.
Comparison of body mass indexes and cutoff points for estimating the prevalence of overweight in Hispanic women.

The anthropometric standards used for estimating the prevalence of overweight among Hispanic groups are generally developed in other populations. Our purpose was to identify appropriate anthropometric indicators and cutoff points for Hispanic women. Data from the Hispanic Health and Nutrition Examination Survey HHANES (1982-1984) included 1,784 Mexican American, 479 Cuban American, and 750 Puerto Rico women aged 25 to 74 years. The body mass indexes examined were weight/ standing height1.5, weight/standing height2, weight/sitting height1.5, and weight/sitting height2. Appropriateness was based on correlation of the index with triceps and subscapular skinfold measurements and lack of association with standing or sitting height. The most appropriate indicator was weight/standing height2. To estimate overweight, the 85th percentiles for weight/standing height2 were obtained from the 20- to 29-year-olds in HHANES and the second National Health and Nutrition Examination Survey (NHANES II). For 10-year age intervals, the differences in proportions of women above those cutoff points were compared with a modified t test. The mean estimated prevalences of overweight were significantly higher with the NHANES II standard compared with the HHANES cutoff points (P
Pesticides for Stored Products

If commodities are to be stored, transported, or processed, they must be protected from deterioration and loss caused by pests. Such losses place a heavy economic burden on the consumer, and their consequences may be disastrous in times of food shortage. Statistics indicate the magnitude of the problem. For example, in a 1947 FAO Survey it was reported that insects destroy at least 5% of the world production of cereal grains. In 29 countries the loss of cereals was 23,355,000 tons, of which 50% was attributed to insects (Cotton and Ashby, 1952).
A New Vision of Healthcare for America

This chapter discusses the new vision of healthcare for America. In the previous decade, the professional guilds ignored the trend toward industrialization, and remained oblivious to the disturbing fact the insurors are rapidly dropping mental health as a benefit. But the new era depends on data, which gives scientifically trained professional psychologist an unprecedented advantage. Future behavioral care may be evidence-based. The first generation saw that 60% of physician visits were by somaticizers. In this generation, the cost offset has increased to a degree in which primary care and behavioral care are coordinated, collaborative, or integrated. The second generation saw the emergence of national organized settings where the managed behavioral care industry came of age and captured most of the insured market. But with carve-out arrangement, it was not possible to conduct medical cost offset between two companies that did not share informatics. In the third generation, a number of organized settings attained the capability of conducting medical cost offset research, and managed behavioral care made a commitment to ongoing outcomes research. Healthcare for older adults is far more costly than that for the younger population. Appropriate behavioral interventions can spare the older adult from a great deal of stress and pain.
15 Gb/s transmission with wide-FSR carrier injection ring modulator for Tb/s optical links

A ring modulator with 22nm free spectral range is modulated and demonstrates an open eye diagram at 15Gb/s. This enables high channel counts towards Terabit per second bandwidth for optical data links using this device architecture.
Genetic Expression of Aryl Hydrocarbon Hydroxylase by 2,3,7,8-Tetrachlorodibenzo-p-dioxin: Evidence for a Receptor Mutation in Genetically Non-responsive Mice

Hepatic aryl hydrocarbon hydroxylase activity is induced by 2,3,7,8-tetrachlorodibenzo-p-dioxin (TCDD) in all inbred strains of mice tested. The genetically "nonresponsive" strains of mice which fail to respond to the usual aromatic hydrocarbons (e.g., 3-methylcholanthrene) are induced by TCDD; however, the dose required is greater than for the genetically "responsive" strains. The dose of TCDD that elicits half the maximal enzyme activity (ED50) in responsive strains, C57BL/6J, BALB/cJ, and A/J, is approximately 1 nmole/kg, and in the nonresponsive strains, DBA/2J, AKR/J, and SJL/J, the ED50 is at least 10 nmoles/kg. In the above strains, TCDD at 3 nmoles/kg fails to induce hepatic aryl hydrocarbon hydroxylase activity in nonresponsive mice, but elicits 70% or more of the observed maximal enzyme activity in responsive strains. In 14 inbred strains of mice, the phenotypic characteristic of aromatic hydrocarbon responsiveness or nonresponsiveness can be detected equally well by a challenge with 3-methylcholanthrene (0.3 mmole/kg) or TCDD at 3 nmoles/kg. In all nonresponsive strains, a 10-fold higher dose of TCDD induces hepatic enzyme activity. The heterozygous offspring of C57BL/6J and DBA/2J parents are distinguishable from both parental strains by an intermediate sensitivity to TCDD. We conclude from these data that the genetically nonresponsive mice have the structural and regulatory genes necessary for the expression of aryl hydrocarbon hydroxylase. The most likely explanation of the defect in nonresponsive mice appears to be a mutation which results in an induction receptor site with a diminished affinity for inducing drugs, leading to an almost absolute unresponsiveness to 3-methyicholanthrene and a diminished sensitivity to the more potent inducer, TCDD.
Comparison of Ventricular Assist Device (VAD)-Related Stroke to the General Stroke Population: Associations with In-Hospital Mortality (P1.223)

Objective: Assess factors associated with in-hospital mortality in VAD-related stroke. Background: Ventricular assist devices (VAD) are associated with an increased rate of stroke. Given the increasing rates of use of such devices, we sought to explore associations between VAD use, ischemic stroke and in-hospital mortality. Methods: Using the 2010-2012 Nationwide Inpatient Sample database, we analyzed all patients with stroke including a subset with VAD (stroke and co-morbidity diagnoses based on ICD-9 diagnosis or procedure codes). Results: Among 395,411 hospitalized stroke patients, VAD placement procedure codes were found in 945 patients (0.25[percnt]), 98.1[percnt] of which were ischemic strokes. Compared to the general stroke population, patients with VAD with stroke (VADWS) were significantly more likely to be young (65[percnt] less than 70 yrs. vs. 46[percnt]), male (67[percnt] vs 47[percnt]), have coronary artery disease (CAD) (85[percnt] vs 25[percnt]), and have acute myocardial infarction (AMI, 66[percnt] vs. 4[percnt]), all p<0.05. In-hospital mortality occurred in 30[percnt] of VADWS compared with 9[percnt] of all strokes. Among those with VADWS, mortality was associated with AMI (OR 1.8, 95[percnt] CI 1.2-2.7), comatose state (OR 3.5, 95[percnt] CI 1.7-7.7), and intubation (OR 2.1, 95[percnt] CI 1.5-2.8). Mortality was less likely in those with pre-existing CAD (OR 0.39, 95[percnt] CI 0.22-0.68). There was no association between in-hospital mortality and age, sex, race, atrial fibrillation, hypertension, or diabetes. Conclusions: Ischemic stroke in patients with VAD is associated with high in-hospital mortality. Although both older patients and women comprised a smaller percentage of VADWS than in the general stroke population, there was no age or sex association with mortality. While pre-existing CAD was more prevalent in VADWS, these patients had lower in-hospital mortality, possibly suggesting an additional unidentified subset with high mortality. Further study is needed to explore the associations between age, sex, and CAD in patients with VAD and ischemic stroke. Disclosure: Dr. Peters has nothing to disclose. Dr. Singh has nothing to disclose. Dr. Tirschwell has received research support from St. Jude Medical and Bayer.
Thermal decomposition of nitrated tributyl phosphate

Extended contact between heated mixtures of tri-n-butyl phosphate (TBP) and aqueous solutions of nitric acid and/or heavy metal nitrate salts at elevated temperatures can lead to exothermic reactions of explosive violence. Most solvent extraction operations are conducted at ambient conditions without heating TBP and have been performed safely for decades, but several explosions involving TBP have occurred in the US, Canada, and the former Soviet Union. This investigation was undertaken to characterize the products of thermal decomposition of both single- and two-phase mixtures of TBP, nitric acid, and water under a variety of conditions. The data indicate that the extent of reaction and the rate of gaseous product formation are affected by the presence of Zr{sup 4+}, distillation compared with reflux conditions, temperature, water/HNO{sub 3} and HNO{sub 3}/TBP ratios, and whether the decomposition occurs under constant pressure or constant volume conditions. Higher reaction temperatures accelerate the rate of decomposition, but the extent of decomposition, as measured by the quantity of gaseous products, was greater at lower temperatures when the decomposition was performed under distillation conditions. Higher gas production occurs under reflux conditions, lower H{sub 2}O/HNO{sub 3} ratios, and when a separate water-HNO{sub 3} phase is initially present. The major gaseousmore » products include N{sub 2}, CO, CO{sub 2}, NO, and N{sub 2}O. Measurable amounts of NO{sub 2} were not present in the final product mixture, although an orange color suggesting the presence of NO{sub 2} was observed in the early stages of decomposition. The major liquid products were dibutyl phosphoric acid, butyl nitrate, and water. Small amounts of C{sub 1}-C{sub 4} carboxylic acids were also present. Because of the small sample sizes that were employed and the isothermal conditions of the decomposition, runaway reactions were not observed. Some possible reaction pathways are considered.« less
Can Hiring Quotas Work? The Effect Of The Nitaqat Program On The Saudi Private Sector

This paper studies the effects of quota-based labor regulations on firms in the context of Saudi Arabia's Nitaqat program, which imposed quotas for Saudi hiring at private firms. I use a comprehensive firm-level administrative dataset and exploit kinks in hiring incentives generated by the quotas to estimate the effects of this policy. I find that the program increased native employment at substantial cost to firms, as demonstrated by increasing exit rates and decreasing total employment at surviving firms. Firms without any Saudi employees at the onset of the program appear to bear most of these costs.
Distributed Computation of Nash Equilibria in Linear Stochastic Differential Games

Abstract In this paper, we study a class of n-person stochastic linear-quadratic differential games under multiple probabilistic modeling, and with each player acquiring a noisy measurement of the initial state. We obtain conditions for the existence and uniqueness of Nash equilibrium, and provide a method for iterative distributed computation of the solution. The distributed algorithm involves learning in the policy space, and it does not require that the players know each other s perception of the probabilistic model underlying the decision process. For the finite horizon problem, such an iteration converges whenever the length of the time horizon is sufficiently small, and the limit in this case is an affine policy for all players if the underlying distributions are jointly Gaussian. When the horizon is infinite, and a discount factor is used in the cost functionals, the iteration converges under conditions depending on the magnitude of the discount factor, the limiting policies being affine in the case of Gaussian distributions.
Simulation of Laser Beam Propagation in Deep Turbulence: Implied Inner Scale and Scintillation

A discrepancy between wave optics simulation and theory has been reported when laser beams propagate through deep turbulence. In this work, we point out that an implied inner scale and outer scale in simulation that could be a likely contributor.
College Student Drinkers Have Higher Self-Compassion Scores than Nondrinkers

Forgiveness, particularly forgiveness of oneself, has been associated with lower alcohol use in several samples. We aimed to confirm this finding in college students and expand it by exploring the relationship of self-compassion to alcohol use. Surprisingly, we found that students who drank (n = 54) scored higher than nondrinkers (n = 30) on the self-kindness and mindfulness aspects of the Self-Compassion Scale, as well as the self-forgiveness aspect of the Heartland Forgiveness Scale. There was no statistical difference between social drinkers and binge drinkers. The relationships of self-compassion and forgiveness to alcohol use and abuse should be further investigated to clarify conflicting results, and a longitudinal cohort study could be particularly useful in elucidating whether self-compassion and forgiveness are related to one’s decision to drink alcohol at all.
Emotions, Terrorist Threat, and Drones: Anger Drives Support for Drone Strikes:

In this article, we investigate how threat perceptions and emotions can jointly impact individuals’ attitudes toward drone strikes. We argue that conditions of threat can increase public support fo...
Formation of Machine Cells: A Fuzzy Set Approach

This research is directed toward developing a group technology (GT) cell formation methodology, with the inclusion of fuzziness commonly found in industry. Specifically, three studies are conducted: 1) The first study establishes a procedure, through which a non-binary machine-component matrix is constructed. This matrix forms the basis of the following two studies. 2) The second study applies the non-binary matrix concept to the single linkage clustering algorithm. 3) The third study focuses on a modified rank order clustering algorithm, which involves fuzzy set theory. The modified single linkage and modified rank order clustering algorithm are compared; the strengths and weaknesses are discussed.
Abstract 4951: Inhibiting guanylate binding protein 1 (GBP1) impedes ovarian cancer progression

Ovarian cancer, the most common gynecologic malignancy, is a leading cause of cancer deaths in women. Seventy percent of patients at diagnosis present with stage III or IV disease, in which the tumor has disseminated beyond the ovaries and pelvic organs to distant sites. Despite resection and and chemotherapy, 80% of patients diagnosed with advanced epithelial ovarian cancer develop recurrent disease and overall prognosis is poor. Resistance to chemotherapeutic agents such as carboplatin and paclitaxel (taxane-based drugs) accounts for the lack of effectiveness of current therapy. Characterization of taxane-resistant tumors has shown that Class III β-tubulin (βTUB3) is significantly overexpressed in ovarian cancer as well as other cancers. Also, molecular characterization of the causes of treatment resistance revealed that βTUB3 plays a prominent role in the incorporation of guanylate binding protein 1, a conditionally expressed GTPase normally involved in the inflammatory response, as one of the critical effectors of taxane and radiotherapy resistance in ovarian cancer. Once in the cytoskeleton, GBP1 binds to pro-survival kinases such as serine/threonine-protein kinase pim-1 (PIM1) and initiates a signaling cascade that induces treatment resistance. We hypothesize that inhibiting the activity of GBP1 will restore sensitivity to taxane therapy. This is now well supported by our preliminary proof-of-concept studies. We have demonstrated that natural product-derived small molecule SU093 stabilizes GBP1 in a nonbinding conformation, resulting in the inhibition of GBP1:PIM1 interaction. The mechanistic studies using confocal microscopy showed that SU093 inhibits GBP1 by blocking its nuclear translocation and disrupts the tubulin dynamics. Cell cycle analysis showed that SU093 leads to G1 phase arrest followed by apoptotic cell death. SU093 treatment also induced pro-apoptotic protein Bax and reduced anti-apoptotic protein Bcl2. Overall, our in vitro and in vivo investigations provide a compelling foundation to develop a novel therapy to treat ovarian cancer by inhibition of GBP1. Citation Format: Dhanir Tailor, Vineet Kumar, Mallesh Pandrala, Angel Resendez, Sanjay V. Malhotra. Inhibiting guanylate binding protein 1 (GBP1) impedes ovarian cancer progression [abstract]. In: Proceedings of the American Association for Cancer Research Annual Meeting 2018; 2018 Apr 14-18; Chicago, IL. Philadelphia (PA): AACR; Cancer Res 2018;78(13 Suppl):Abstract nr 4951.
The new institutional economics (NIE) approach to geographical indication (GI) supply chains: A case study from Turkey

Abstract Agrifood systems have been experiencing major changes worldwide, generating tensions and conflicts that are reflected in international trade negotiations, and resulting in a significant move toward market differentiation in many parts of the world. One essential strategic response to these changes is increased institutionalization of food quality and safety, and resulting institutional arrangements in agrifood systems. By drawing on the new institutional economics literature, this chapter discusses how institutional arrangements are related to institutionalization of food quality and safety and how institutions should govern agricultural supply chain activities to ensure high quality standards. Relatedly, we discuss a quality convention called geographical indications (GIs) and illustrate our discussion by using a notable GI case study from Turkey: Gemlik table olives. We draw implications for the literature on institutional arrangements and discuss implications for further research on institutional arrangements in agrifood supply chain networks.
Lightweight alternatives to glass fiber/epoxy sheet molding compound composites: a feasibility study

The focus of this study is to (i) understand the effect of the fiber type and content on the mechanical properties of sheet-molding compounds composites and (ii) investigate possible lightweight al...
Decolonizing the Church/Decolonizing Language: Postcolonial Christianity, Language Ideologies, and the Morality of Teaching Vernacular Arabic (Darija) in Algeria

In the mid-20th century, as the global colonial order collapsed, language and education were two of the most affectively, politically, and economically challenging domains of decolonization efforts. Parler Algerien (Speak Algerian), an experimental method for the teaching and learning of Darija (Algerian vernacular Arabic), created by Catholic clergymen and women in the early 1970s, provides an illustration of an attempt to decolonize language learning in postcolonial Algeria. The Catholic creators of Parler Algerien assumed a stance of solidarity with the independent nation, an alignment that translated into the entextualization of a number of linguistic and non-linguistic features in the textbook. This ethnography of a Darija classroom examines the shifting language ideologies that mediate the text’s interpretation in the 21st century. I argue that the interdiscursive residues of Parler Algerien’s postcolonial context of production shape its uptake in the 21st century classroom, but not in the w...
“I Am Double The Bi”: Positive Aspects of Being Both Bisexual and Biracial

The present research investigates the positive experiences of individuals who identify as bisexual/plurisexual and biracial/multiracial. Participants included 107 adults who self-identified as bise...
Ewing Sarcoma Cells Are Sensitized to NK Cell Mediated Killing by SNDX-275, An HDAC Inhibitor

Abstract 1126 Natural Killer (NK) cells are an important a part of the innate immune system response to infection and malignancy. Tumors may escape NK cell surveillance by upregulating expression of inhibitory ligands (HLA), or downregulating expression of activating ligands (MICA/B, ULBP). Histone Deacetylase (HDAC) inhibitors promote cell cycle arrest, differentiation, and apoptosis in tumor cells by decompacting chromatin to a more transcriptionally active state. In previous studies, we and others have shown that HDACi can sensitize tumor cells to NK cell mediated cytotoxicity by modulating expression of activating or inhibitory receptors. We investigated whether HDACi could modulate sensitivity of Ewing Sarcoma (EWS) cell lines to lysis by NK cells. EWS cells were cultured in vitro in the presence of SNDX-275, a Class I HDAC inhibitor, for 24, 48 and 72 hours, and then assessed for viability, cell proliferation, expression of activating and inhibitory receptors, and susceptibility to NK cell mediated cytolysis. We found a dose and time dependent inhibition of EWS cell proliferation mediated by SNDX-275. We also found a dose and time dependent decrease in the expression of HLA on tumor cell surface, which correlated with drug treated cells being more susceptible to NK cell mediated killing. SNDX-275 not only has a direct toxicity on Ewing sarcoma cells but it also appears to improve NK cell mediated cytolysis of these cells by down regulation of HLA, an inhibitory receptor of NK cells. Disclosures: No relevant conflicts of interest to declare.
Introduction: Recent Research in Assessment in Education Abroad

The Guest Editors introduce their virtual issue on Recent Resarch in Assessment in Education Abroad, which curates past articles published in Frontiers on the topic. Click on the links beside each selected article in the REFERENCES section below to read the full article.
Adaptive path planning of novel complex parts for industrial spraying operations

Industrial spraying operations in high-mix, low-volume manufacturing are usually not automated due to variety and variability among workpieces. Automated path planning for industrial spraying opera...