cssi/SciSciGPT-SciSciNet huggingface dataset:
Transformative 3D Immersive Collaboration Environment in Support of AEC Global Teamwork

Corporate experience claims that the most efficient interactions are when all project stakeholders are collocated. This is extreme collaboration when people, content, models, and processes are collocated. Nevertheless, the AEC industry experiences a continuous increase in mobility, globalization, collaboration, digital content, interactivity, and convergence of physical and virtual workplaces. This paper presents transformative impacts on product, process, and interaction of immersive 3D virtual collaboration environment in support of global teamwork. The empirical data and findings are based on longitudinal studies performed over four years observing 24 cross-disciplinary, geographically distributed AEC student project teams in the AEC Global Teamwork education testbed. The deployment and adoption of agile integrated project delivery work practices facilitated by the immersive 3D virtual collaboration environment demonstrate innovative and effective new ways of working such as co-creation of collaboration spaces, content in context, experiencing and troubleshooting design and construction issues in the virtual BIM models.
Viruses as potential regulators of regional brown tide blooms caused by the alga,Aureococcus anophagefferens

Blooms of the brown tide organism Aureococcus anophagefferens have recurred in the coastal bays in New Jersey since 1995 and in the coastal bays of Long Island since 1985. Intracellular viral-like particles (VLPs) were docu- mented during 1999-2000 brown tide blooms in Little Egg Harbor, New Jersey, but it was not determined whether cells were infected during the termination of the bloom. The objective of this study was to determine if VLPs infected and lysed natural populations of A. anophagefferens in coastal bays of New Jersey and New York in 2002 with the same frequency as in 1999-2000 and especially at the termination of the bloom. Our results confirmed that the highest percentage (37.5%) of VLP-infected cells occurred at the termination of the brown tide bloom in New Jersey in 2002. Intracellular VLPs were present throughout the bloom event. The percentage of visibly infected cells was higher at the beginning of the bloom than during the peak of the bloom. The intracellular VLPs in natural populations of A. ano- phagefferens were consistent in size and shape (approximately 140 nm in diameter) and comparable to those in previous studies. Concentrated viral isolates, prepared from waters during brown tide blooms in New York and New Jersey in 2002, infected healthy laboratory A. anophagefferens cultures in vitro. The viral isolates associated with the highest labo- ratory viral activity (lysis positive) were concentrated from water samples having the highest viral and bacteria concen- trations. The intracellular viruses in these virally infected laboratory cultures of A. anophagefferens were similar in size and shape to those found in natural populations. The successful isolation of a virus specific to A. anophagefferens from a brown tide bloom in the field, the similarity of ultrastructure of VLPs infecting both natural populations and laboratory infected cultures, and the pattern of VLP infection during bloom activity in combination with the observed high per- centage of VLP-infected cells during bloom termination, supports the hypothesis that viruses may be a major source of mortality for brown tide blooms in regional coastal bays of New Jersey and New York.
Characterization of a monoclonal antibody against latex protein associated with latex allergy

Several hybridomas were produced against antigens extracted from the latex sap of Hevea brasiliensis. One of the monoclonal antibodies (LA-E3) reacted with antigens demonstrating binding to patient sera on crossed enzyme immunoelectrophoresis. This monoclonal antibody reacted with 2 of 10 glove extracts studied and with both Malaysian and Indian latex plant extracts. The antigens purified with monoclonal antibody affinity chromatography demonstrated specific IgE in the sera of patients with latex allergy as determined by ELISA. This monoclonal antibody can thus be utilized to obtain reliable antigens useful in the diagnosis of latex sensitivity, although additional antigens will likely be necessary to enhance sensitivity and specificity.
Total ionizing dose and displacement damage effects on TaO x memristive memories

The effects of ionizing radiation and displacement damage on TaO x memristors are evaluated. Devices show little response to 10 keV x-rays up to 10 Mrad(Si). Co60 gamma rays and 4.5 MeV protons did not change the resistances significantly at levels up to 2.5 Mrad(Si) and 5 Mrad(Si) respectively. 105 MeV and 480 MeV protons cause switching of the memristors from high to low resistance states in some cases, but do not exhibit a consistent degradation. 800 keV silicon ions are observed to cause resistance degradation, with an inverse dependence of resistance on oxygen vacancy density. Variation between different devices appears to be a key factor in determining the electrical response resulting from irradiation. The proposed degradation mechanism likely involves the creation of oxygen vacancies, but a better fundamental understanding of switching is needed before a definitive understanding of radiation degradation can be achieved.
Microanalysis of Urinary Electrolytes and Metabolites in Rats Ingesting Dimethyl Terephthalate

Quantitative methods are described for the analysis of pH, sodium, ammonium, potassium, calcium, magnesium, chloride, phosphate, and sulfate, as well as terephthalic acid and dimethyl terephthalate, in a single urine sample as small as 20 microliter. The procedure utilizes ion chromatography and atomic absorption for electrolyte analysis, a microelectrode for pH measurement, and high-performance liquid chromatography for analysis of the organic compounds. The techniques are applied to urine samples freshly collected from rats ingesting dietary dimethyl terephthalate. Specific changes in urinary ions, including hypercalciuria and urinary acidosis, are shown to develop as a consequence of dimethyl terephthalate ingestion. The results indicate that metabolism of dimethyl terephthalate to terephthalic acid occurs extensively in Fischer-344 rats, and accounts for the ion changes that are observed.
The Changing American Hospital in the Twenty-first Century

One is always hesitant to speak about the future. A famous philosopher from New York, Yogi Berra, said "Making predictions is difficult, especially about the future," and I have some trepidation about doing so now. There is also the difficulty of understanding what really has happened in the past. I recall the Bolshevik general in 1917 who said "The future is clear, but the past is very murky." We anticipate the future with more clarity than is justified, even as we disagree on what is happening right now or what happened before. In that vein, I will describe the role of the American hospital in our health care system, and the challenges it must meet, reviewing first the murky past by summarizing trends that have made hospitals what they are today.
The Multicomputer Toolbox: current and future directions

The Multicomputer Toolbox is a set of "first-generation" scalable parallel libraries. The Toolbox includes sparse, dense, direct and iterative linear algebra, a stiff ODE/DAE solver, and an open software technology for additional numerical algorithms. The Toolbox has an object-oriented design; C-based strategies for classes of distributed data structures (including distributed matrices and vectors) as well as uniform calling interfaces are defined. At a high level in the Toolbox, data-distribution-independence (DDI) support is provided. DDI is needed to build scalable libraries, so that applications do not have to redistribute data before calling libraries. Data-distribution-independent mapping functions implement this capability. Data-distribution-independent algorithms are sometimes more efficient than fixed-data-distribution counterparts, because redistribution of data can be avoided. Underlying the system is a "performance and portability layer," which includes interfaces to sequential BLAS, the Zipcode message passing system, and a minimal set of Unix-portability functions. In particular, the Zipcode system provides communication contexts, and process groups, collective operations, and virtual topologies, all needed for building efficient scalable libraries, and large-scale application software. >
Intensive Outpatient Services

There is a wide range of behavioral services available to assist with the assessment and treatment of problem behavior exhibited by individuals with developmental disabilities. However, options at either end of the continuum (i.e., brief outpatient on one end, inpatient on the other) may not be able to address some behavior problems due to various factors. The information presented in the chapter describes, and is based on, an existing service-delivery model that lies somewhere between outpatient and inpatient services, with respect to intensity of services: intensive outpatient services. The chapter focuses on the referral processes, clinical progression, and care provider-training issues. Case examples are also discussed. Issues related to functional analysis of problem behavior as part of the clinical progression will be discussed in relative detail.
University Research and Licensing

This chapter in an overview of the law of bioinformatics covers the legal issues uniquely facing universities and other research institutions. Among the topics covered are modes of university technology development, the Bayh-Dole Act, the questionable status of the patent research exemption in the U.S., publication and data release, and socially-responsible licensing.
Increasing Concentrations of Perhalocarbons, Methylchloroform and Methane in the Atmosphere

Publisher Summary There are increasing concentrations of the trace species CCl3F, CCl2F2, CCl4, CH3CCl3, and CH4 in the atmosphere because of the increasing use by humans. Further increases in these and other trace chemical species will certainly occur in the coming decade and in the foreseeable future. These increases are connected with potentially important alterations of the environment through the depletion of ozone at 40 km and through the infrared greenhouse effect. Control procedures toward the atmospheric emissions of these compounds have been limited to CCl3F and CCl2F2 and to their specific uses as aerosol propellant gases in the United States, Canada, and several Scandinavian countries. The most significant environmental concern is that the concentrations are increasing for most of the trace species that have been quantitatively studied in the atmosphere. With so many chemical compounds exhibiting a trend in the same direction, the possibility for eventual serious alterations in the entire structure of the atmosphere needs to be very carefully monitored and evaluated.
Collegial mentoring through routine patient consultation—a new learning strategy in outpatient physical therapy settings

(geriatric depression scale: GDS), balance (functional balance scale: FBS), and urinary incontinence were evaluated. Results: Among the 130 elderly people with disuse syndrome (mean± standard deviation age, 78.3± 10.5), 71 people were classified in the independent group and 59 in the dependent group. The mean duration of hospitalization was 21.3± 15.1 days. According to the univariate analysis, the number of days from onset to the start of rehabilitation, consciousness, transportation, grip strength, range of motion (extension of hip joint), and MMSE, GDS, and FBS scores was significantly different between the two groups. According to the multivariate logistic regression analysis, MMSE [odds ratio (OR), 1.31; 95% confidence interval (CI), 1.13–1.53; p= 0.001] and GDS (OR, 0.80; 95% CI, 0.66–0.97; p= 0.03) were factors associated with the FIM score at discharge. Conclusion(s): Our study results suggested that cognitive levels and depressive state at the start of rehabilitation were associated with the ability of elderly people with disuse syndrome to recover independent ADL. Implications: The results of this study can be used to predict the prognosis of people who are hospitalized for internal disease. In addition, an early examination of mental function may be important for elderly people who undergo rehabilitation.
Petroleum geologic conditions and accumulation history of Middle Devonian,southern Guizhou province

In the Dushan Formation of the Middle Devonian in the southern Guizhou province,the mudstone source rocks of trough-basin facies are widespread with high organic abundance.The average organic carbon content is 3.02%.Most of the kerogens are of type Ⅱ1,and some are of type Ⅰ,indicating for excellent hydrocarbon generation conditions.In carbonate and sandstone reservoirs,intergranular,intergranular pores and cracks develop well.Cap rocks distribute widely and are preserved well,indicating for strong sealing capacity.Petroleum shows prove that,in both carbonate and sandstone reservoirs in the Middle Devonian,uneven organic matter or asphalt infillings can be found.The homogenization temperatures of fluid inclusions in the Dushan Formation show that the study area has experienced 2 phases of hydrocarbon charging.At the end of Devonian,the southern Guishou province was the uplifting area of the Ziyun Movement,hence was favorable for petroleum charging during the early Carboniferous.Petroleum migrated along cracks to the reef flat limestone reservoirs and the littoral sandstone reservoirs in platforms and platform edges.
Telephone Encounters in Inflammatory Bowel Disease (IBD) Care: Burden, Risk Factors, and Opportunities for Intervention

Telephone communication is an integral part of modern life in the USA, including health care. Telephone communication among patients, care providers, pharmacies, and insurers is now an established interchange in health care, and this is especially true for the care of chronic illness, including the inflammatory bowel diseases (IBDs). Telephone encounters in the care of patients with IBD have taken on further importance, in part due to the younger age demographic of this patient population and their comfort and familiarity with technology, as well as the acuity and severity of these diseases and their need to interact with health care. Telephone communication in IBD is multidirectional and involves patient contacting care providers with questions and clinical status updates as well as the background communication among the health-care providers, pharmacies, and payors (i.e., insurance companies) for authorization of prescriptions, diagnostic testing, and procedure scheduling. A comprehensive evaluation on the spectrum of telephone activity in IBD management was recently conducted by our center, and the findings indicate that the volume of telephone activity is double the number of clinic encounters. Furthermore, the record of telephone encounters embedded in the electronic medical record functioned as a robust indicator of clinical status. Stratification of IBD patients by patterns of annual telephone activity demonstrated that a subset of patients is responsible for the majority of telephone encounters, and these patients reflect a heterogeneous complexity of illness.
Effect of protein source and grain type on finishing calf performance and ruminal metabolism.

A finishing trial and a metabolism trial were conducted to evaluate sources of supplemental protein in dry-rolled corn (DRC) and dry-rolled grain sorghum (DRGS) diets fed to large-framed calves and to determine effects of grain and protein source on ruminal metabolism. In Exp. 1, 144 Charolais crossbred steer and heifer calves (BW = 269 +/- 3 kg) were used in a randomized complete block design and fed (199 d) DRC or DRGS diets supplemented with urea or urea plus a 60:40 combination (CP basis) of blood meal (BM) and feather meal (FTH). Calves supplemented with urea-BM/FTH were more efficient (P .2) by source of protein. The NRC metabolizable protein (MP) requirements accurately predicted response to urea-BM/FTH. In Exp. 2, five ruminally cannulated steers (BW = 721 +/- 20 kg) were used in a 5 x 5 Latin square design and fed (on an ad libitum basis) diets similar to those used in Exp. 1. An additional treatment of DRC supplemented with soybean meal (SBM) was included. Rate (P < .01) and extent of 12-h (P = .14) and 18-h (P < .05) in situ N disappearance of SBM, BM, FTH, DRC, DRGS, and corn silage were greater when diets were supplemented with urea-BM/FTH or SBM. Estimates of escape N (percentage of total N) were 52.3, 93.3, 91.7, 65.7, 63.6, and 23.2% for SBM, BM, FTH, DRC, DRGS, and corn silage, respectively. Finishing calves supplemented with urea were deficient in MP during the early finishing period (0 to 41 d) but were adequate in MP from d 42 to slaughter. Supplementing urea-BM/FTH improved feed efficiency when MP was limiting but not when MP was adequate.
Atherosclerotic Cardiovascular Mortality in the Island of Crete Study

The aim of epidemiological studies in Greece, as part of an international co-operative program, was to 1) examine a definite group of middle age men living under similar conditions, 2) to follow the subsequent disease experience of these men and 3) to discover possible relationships between the pre-disease characteristics and the incidence of the disease, notably cardiovascular (CVD), resulting from atherosclerosis.
Attention and Driving: Assessment in Elderly Individuals with Dementia

Older drivers with dementia are involved in more crashes than healthy older drivers. Some investigators, therefore, have proposed that a diagnosis of dementia (DAT or other type) should lead to the automatic revocation of a driver's license. In the authors' view, however, renewal of license should be based on criteria related to driving competence rather than solely on chronologic age or a medical diagnosis. Unfortunately, current competency testing procedures do not assess the attentional factors discussed herewith that have been found to be important for safe driving. As the studies reviewed in this article reveal, there is good evidence that a skill test that predicts crash involvement in older drivers should incorporate attentional measures, in particular tests of attentional shifting based on dichotic listening and related tests. There is also evidence that attention-shifting measures are diagnostic of attention impairment in the early stages of Alzheimer-type dementia. Further research is needed to determine whether other attentional skills, such as sustained and divided attention, also need to be assessed. Additional work also is needed to refine attention tests for ease of use in the clinical setting. Lastly, although these attention measures account for only some of the variance contributing to crash involvement, they may allow for better predictive capability when combined with measures of other skills involved in driving. Driver training programs can complement driver testing procedures in serving the dual requirement for reducing crash risk among drivers with dementia while continuing to be responsive to their mobility needs. Information on the role of attention and other cognitive skills in safe driving should be made available, so that drivers (or their family members) who think they may have declining skills can seek further evaluation. Organizations such as automobile associations and retired persons groups can provide self-assessment inventories for completion by older drivers or referral for medical and neuropsychological evaluation. Finally, training techniques for improving attentional skills in drivers with DAT need to be developed and tested.
Epidemiology and Culture: Perceiving and Representing Risk

Epidemiologists came under increasingly critical public scrutiny in the 1990s. In 1993 the Lancet published an editorial with the provocative heading “Do epidemiologists cause epidemics?” It inquired whether epidemiologists were making too many errors in their calculations of disease burden and causation, and whether the public was placing excessive confidence in – and deriving excessive anxiety from – epidemiological results. A 1995 news report in the journal Science , titled “Epidemiology faces its limits,” began with this devastating sentence: “The news about health risks comes thick and fast these days, and it seems almost constitutionally contradictory” (Taubes 1995:164). As the cartoon in Figure 7.1 makes clear, epidemiology has increasing presence in the mass media, but its recommendations for how to maintain health and avoid disease seem arbitrary and subject to rapid change. Yet people seek more information about risk even if they do not quite know what it is. Epidemiology has, until recently, been an accepted source of evidence in many countries about how to identify and reduce disease risk. But that disciplinary authority is increasingly contested by representatives of private industry, government, and the public, who struggle to establish their own definitions of risk and rational solutions to the problem of risk. Because their messages are no longer broadcast only within the profession, epidemiologists' growing engagement in public affairs raises the stakes for the discipline.
A Frequency Addressable Ultrasonic Microfluidic Actuator Array

In this paper, a microfluidic ultrasonic multi-actuator paradigm is introduced. Mixing, pumping, and particle capture are achieved by actuating polysilicon center-anchored circular plates and polysilicon sidewall cantilevers at ultrasonic frequencies using a single piezoelectric PZT (Lead Zirconate Titanate oxide) plate. Frequency addressability of acoustic streaming at surface microstructures is demonstrated by driving the bulk structure at the microstructure resonance frequencies. The actuator array is placed inside a microfluidic channel with a Reynold’s number of approximately 0.1. Standing and rotating mode shapes of the polysilicon structures have been observed using an optical interferometer in the frequency range of 200 kHz to 10 MHz. Frequency dependent fluid motion was qualitatively deduced and experimentally verified using dimensional analysis of micro-acoustic-streaming.
Mumps, Measles and Rubella Vaccination and Encephalitis

A case of encephalitis in a 14 month old girl occurring 27 days after immunization with MMR vacine is reported from the Department of Child Health, Charing Cross Hospital, London, England.
Predictors of survival in patients with transformed chronic lymphocytic leukemia (TC).

7098 Background: Patients with CLL that develop Richter’s syndrome (RS) have a very poor prognosis. Similarly, pts with CLL that have clinical and histological features (increased large cells/prolymphocytes in CLL tissue biopsy) of increased aggressiveness (defined as accelerated phase CLL, AP) have a poor prognosis. In order to identify prognostic factors in pts with AP and RS, collectively referred to as TC, we reviewed our center experience. Methods: Pts with TC and complete evaluation including biopsy and concomitant FDG/PET were included. Pts with de novo TC were excluded as their prognosis is substantially superior versus previously treated pts. Pts with N+ or M+ concurrent solid tumors were also excluded. Since FDG/PET-derived SUV reflects tumor proliferative rate, we used SUVmax≥10 to indicate high-risk disease (Falchi, Blood. 2012;120: abstr # 927). We identified factors associated with outcome and performed a multivariable model for OS. Results: One hundred eighty-three consecutive pts with TC (...
Silent whistle: Effective indoor positioning with assistance from acoustic sensing on smartphones

Indoor positioning systems provide location information without the ability to use GPS. Indoor positioning faces challenges of accuracies and pervasiveness. In this paper, we present SilentWhistle, a mobile system that incorporates acoustic information and motion traces on smart phones to locate users. SilentWhistle does not expose the identity of a mobile device as does Bluetooth or Wi-Fi communications. By detecting and filtering the received audio frequencies, we encode the frequencies to location information. When users encounter each other or related beacons, by measuring the relation between sound strength and distance, the initial location information obtained by dead reckoning can be enhanced by triangulations transferred from sound strength. Centralized and distributed models of SilentWhistle can avoid the spreading of incorrect location messages. Our case studies agree on SilentWhistle is capable of obtaining location with error of less than 1.25m.
Optical Modulation and Antialiasing Methods for Experimental Verification of Sensor Signal Integrity

In this paper, the use of laser modulation for characterizing the sensitivity of infrared sensors and autonomously adjusting frame rates are discussed. Lasers modulated at frequencies near the frame rate of the sensor under test demonstrated a more significant effect than modulation frequencies further from the frame rate. A method to quantify the effectiveness of a particular laser modulation frequency was developed. Experimental runs with and without laser tracking are compared in order to demonstrate how the laser affects the tracking algorithms of the sensor. The effect of the relationship between the modulation frequency and the frame rate on the sensor’s accuracy is also determined. An algorithm was developed to improve a sensor’s ability to detect signals modulated at its frame rate. The paper concludes with discussions on applications of these results to commonly available sensor systems.
Effect of betulinic acid and its ionic derivatives on M-MuLV replication

Murine leukemia virus (MuLV) is a retrovirus known causing leukemia and neurological disorders in mice, and its viral life cycle and pathogenesis have been investigated extensively over the past decades. As a natural antiviral agent, betulinic acid is a pentacyclic triterpenoid that can be found in the bark of several species of plants (particularly the white birch). One of the hurdles for betulinic acid to release its antiviral potency is its poor water solubility. In this study, we synthesized more water-soluble ionic derivatives of betulinic acid, and examined their activities against Moloney MuLV (M-MuLV). The mouse fibroblast cells stably infected with M-MuLV, 43D cells, were treated with various doses of betulinic acids and its derivatives, and the viral structural protein Gag in cells and media were detected by western blots. Two ionic derivatives containing the benzalkonium cation were found to inhibit the virus production into media and decreased Gag in cells. However, a cell proliferation assay showed that the benzalkonium cation inhibited the growth of 43D cells, suggesting that our ionic derivatives limited virus production through the inhibition of metabolism in 43D cells. Interestingly, all of these betulinic acid compounds exhibited a minimum impact on the processing and release of Gag from 43D cells, which outlines the differences of viral maturation between MuLV and human immunodeficiency virus.
Community technology mapping: inscribing places when “everything is on the move”

Interactive, digital mapping technology is providing new pedagogical possibilities for children and their families, as well as new methodological opportunities for education researchers. Our paper reports on an example of this novel terrain we call “Community Technology Mapping” (CTM). CTM was a designed task that was part of a larger ethnographic study of children and families’ digital media and technology practices in and around their homes. CTM incorporated interactive digital mapping technology with a structured interview protocol as a pedagogical context for young people and a methodological tool for researchers. As a pedagogical context for computer-supported collaborative learning, CTM supported young people to see and reflect on their everyday technological practices as temporally and spatially organized across scales of human interaction. As a methodological tool, CTM allowed researchers to see families’ place-based and on-the-move activities that were outside the more naturalistic observations of home-based technology use. Our analysis of CTM draws upon video recordings and screen captures of young people’s reflections on and live mappings of places they typically used technology and engaged with media. We found that children developed strategies with the mapping technology to make places visible, make them coherent, and make them mobile. These strategies produced a “cascade of inscriptions” within the CTM task for mapping new mobilities of digital, daily life. We argue that interactive digital mapping technologies not only support researchers to ask new questions about the spatiotemporal aspects of learning phenomena, but also contribute to a new genre of place-based, digital literacies- locative literacy- for learners to navigate.
On Sidelobe Problem of Configured Array Antennas

A sidelobe problem that appears in some configurations of dual linear polarized patch antenna array is discussed. The properties of patch radiation patterns which cause such problem are identified and related to the asymmetry of the probe location with respect to the center of the patch antenna. The requirement of the element radiation pattern to avoid the increased sidelobe is calculated. Radiation patterns of a symmetrical crossed dipole antenna which meet the above-mentioned requirement have been utilized to form planar arrays with different configurations. The results indicate that the sidelobe issue that appears with the patch antenna will no longer exist in the proposed crossed dipole array antenna. The symmetry feature, emphasized in this paper, can be applied to any future element to attain low cross-polarization with removed sidelobe problems in their corresponding imaged array configurations.
Raman Scattering in the Narrow Gap Alloy Hg1-XCdxTe

We have investigated polarization dependent Raman scattering from the , and surfaces of P-Hg1-xCdxTe (x≈0.2; Eg≈ 100 meV) and HgTe (zero-band gap) single crystals. In addition to the q=0 longitudinal (LO) and transverse (TO) optical phonon peaks we have observed several other features, some of which may be due to deviations from perfect crystallinity. An extremely surface sensitive feature was observed from p-Hg0.8Cd0.2 Te has been tentatively assigned to a coupled LO phonon-intersubband transition in the naturally occurring surface inversion layer. A new feature has been seen in HgTe, which may be due to a screened LO phonon.
THE DEVELOPMENT OF GLAUCOMA IN RABBITS.

In an attempt to study the development of glaucoma in rabbits, animals with established, glaucoma and buphthalmos were bred, and their offspring followed with tonography at monthly intervals. Findings indicated that: (A) The animals developing glaucoma, as determined by a corneal diameter of 17 mm. or more at 1 year of age, had elevated intraocular pressures at 5 to 6 months of age, and impaired outflow facilities as early as 3 months of age. (B) Animals with corneal diameters of 15 mm. or less at 1 year showed no pressure elevations, and had much higher outflow facilities throughout the first year of life.
Outcomes of metastatic adrenocortical carcinoma (ACC): A 16-year single institutional experience.

e16088Background: ACC is a rare malignancy with limited data to guide management of metastatic disease. Prior research regarding survival has focused on pts with locoregional disease, but has not o...
Cardiac CT: Electrophysiological Applications

The increasing disease burden caused by atrial fibrillation has led to new interventions aimed at restoring normal sinus rhythm and preventing embolic complications. Cardiac CT can help identify suitable candidates, plan the intervention, and diagnose complications. In some institutions, this application has become the most common indication for the clinical use of cardiac CT. Consequently, expertise in making the pertinent observations outlined in this chapter is of critical importance for the success of any cardiac CT program and offers a tremendous opportunity for interdisciplinary collaboration.
Potential best practices for assessment of interprofessional team-ready behaviors on APPEs

Abstract Introduction To determine potential best practices for assessment of team-ready behaviors of pharmacy students participating in interprofessional advanced pharmacy practice experiences (APPEs). Methods Preceptors received training on two interprofessional behavioral assessment tools, the modified interprofessional collaborator assessment rubric (mICAR) and individual teamwork observation and feedback tool (iTOFT). Preceptors evaluated students at midpoint and end of APPE using each tool. Preceptors completed a utility survey on each tool to determine a preference. Focus groups were conducted with a subset of preceptors to elicit further perspectives. Experts in interprofessional education (IPE) and accrediting board members were interviewed to determine a national perspective of best practices. Results Nineteen preceptors participated in the study. Of these, 12 completed all components of the study. No significant difference was found comparing utility of mICAR to iTOFT, although mICAR trended toward being easier to use/understand (p = 0.29). Focus group participants (n = 8) felt using a tool led to enhanced feedback and interprofessional experiences and all preferred mICAR. IPE experts and accrediting board members perceived best practices to include using a tool that aligns with IPE collaborative competencies, embedding the tool into existing APPE evaluation processes, and that is applicable to all health professional learners/evaluators. Conclusions Preceptors preferred mICAR to iTOFT, though no significant difference was observed. Additional research is needed to confirm these results and for best practices to emerge. Future steps include evaluating interprofessional teamwork using a tool in a 360-evaluation of the individual learner by preceptors outside of the learner's own profession.
Addiction treatment in the postpartum period: an opportunity for evidence-based personalized medicine

Substance use disorders (SUD) are becoming rapidly more prevalent in women and a leading cause of pregnancy associated deaths, with most deaths occurring during the 12 months after pregnancy. The postpartum period can be quite intense, especially for women seeking addiction recovery. There is a call to reconceptualize the obstetrical postpartum care model into one that extends specialised care and is tailored to an individual’s specific needs. Although SUD treatment improves maternal and infant outcomes as well as decreases overdose risk, many women do not receive consistent SUD treatment during the postpartum period. Thus, SUD treatments should consider following the same guidance as obstetrics to reconceptualize how SUD treatment is delivered postpartum. Clinically, this translates into substantially modifying traditional siloed SUD treatment structures to meet the unique needs of this vulnerable patient population. At the same time, more research is urgently needed to inform these advancements in clinical care to ensure they are evidence-based and effective. In this article, we review the existing evidence as well as highlight opportunities for both clinicians and researchers to advance the integration of tailored approaches for postpartum women into personalised SUD medical and behavioural treatments.
In vivo spectral editing of phosphorylethanolamine.

Purpose To demonstrate J-difference editing of phosphorylethanolamine (PE) with chemical shifts at 3.22 (PE3.22 ) and 3.98 (PE3.98 ) ppm, and compare the merits of two editing strategies. Methods Density-matrix simulations of MEGA-PRESS (Mescher-Garwood PRESS) for PE were performed at TEs ranging from 80 to 200 ms in steps of 2 ms, applying 20-ms editing pulses (ON/OFF) at (1) 3.98/7.5 ppm to detect PE3.22 and (2) 3.22/7.5 ppm to detect PE3.98 . Phantom experiments were performed using a PE phantom to validate simulation results. Ten subjects were scanned using a Philips 3T MRI scanner at TEs of 90 ms and 110 ms to edit PE3.22 and PE3.98 . Osprey was used for data processing, modeling, and quantification. Results Simulations show substantial TE modulation of the intensity and shape of the edited signals due to coupling evolution. Simulated and phantom integrals suggest that TEs of 110 ms and 90 ms were optimal for the edited detection of PE3.22 and PE3.98 , respectively. Phantom results indicated strong agreement with the simulated spectra and integrals. In vivo quantification of the PE3.22 /total creatine and PE3.98 /total creatine concentration ratio yielded values of 0.26 ± 0.04 (between-subject coefficient of variation [CV]: 15.4%) and 0.18 ± 0.04 (CV: 22.8%), respectively, at TE = 90 ms, and 0.24 ± 0.02 (CV: 8.2%) and 0.23 ± 0.04 (CV: 18.0%), respectively, at TE = 110 ms. Conclusion Simulations and in vivo MEGA-PRESS of PE demonstrate that both PE3.22 and PE3.98 are potential candidates for editing, but PE3.22 at TE = 110 ms yields lower variation across TEs.
Bactericidal properties of the concentrated artificial kidney bath solution.

Abstract This study was undertaken to investigate the ability of a 30 times concentrated dialysate fluid to support or inhibit growth of bacteria, and to evaluate its shelf life. The solution was inoculated with the following organisms in the logarithmic-growth phase: Escherichia coli, coagulase-positive Staphylococcus aureus, enteric Streptococcus sp., Pseudomonas sp., Klebsiella-Aerobacter sp., Proteus sp., and Bacillus subtilis. Inoculated concentrate held at 37 C showed an exponential decrease in organisms for all species except B. subtilis, with no organisms recoverable at 24 hr. To determine the effects of temperature, solution inoculated with E. coli and S. aureus was kept at 4 and 20 C. Lesser rates of bacterial decline were found at the lower temperatures, with some organisms surviving for 146 hr at 4 C. For the evaluation of shelf life, 2 liters of the solution was kept at room temperature in screw-cap bottles for 8 months; no bacterial growth occurred. The self-sterilizing property of this solution is important practically, since it removes another source of contamination from patients with reduced resistance to infection due to chronic renal disease or immunosuppressive therapy for renal homotransplantation.
Peak Cardiac Power Measured Noninvasively With a Bioreactance Technique Is a Predictor of Adverse Outcomes in Patients With Advanced Heart Failure

Peak oxygen consumption (VO(2) ) during cardiopulmonary exercise testing (CPET) is a powerful predictor of survival, providing an indirect assessment of cardiac output (CO). Noninvasive indices of CO derived from bioreactance methodology would add significantly to peak VO(2) as a means of risk-stratifying patients with heart failure. In this study, 127 patients (53 ± 14 years of age, 66% male) with heart failure and an average ejection fraction of 31% ± 15% underwent symptom-limited CPET using a bicycle ergometer while measuring CO noninvasively by a bioreactance technique. Peak cardiac power was derived from the product of the peak mean arterial blood pressure and CO divided by 451. Follow-up averaged 404 ± 179 days (median, 366 days) to assess endpoints including death (n=3), heart transplant (n=10), or left ventricular assisted device implantation (n=2). Peak VO(2) and peak power had similar areas under the curve (0.77 and 0.76), which increased to 0.83 when combined. Kaplan-Meier cumulative survival curves demonstrated different outcomes in the subgroup with a VO(2) <14 mL/kg/min when stratified by a cardiac power above or below 1.5 W (92.2% vs 82.1% at 1 year and 81.6% vs 58.3% at last follow-up, P=.02 by log-rank test). Among patients with heart failure, peak cardiac power measured with bioreactance methodology and peak VO(2) had similar associations with adverse outcomes and peak power added independent prognostic information to peak VO(2) in those with advanced disease (eg, VO(2) <14 mL/kg/min).
Scored Protein-Protein Interaction to Predict Subcellular Localizations for Yeast Using Diffusion Kernel

Network-based protein localization prediction is explored utilizing the protein-protein interaction score along with the network connectivity. Score-based diffusion kernel is introduced to solve the problem. Four different PPI networks, namely, co-expressed PPI, Genetic PPI, Physical PPI, and scored PPI are used for analysis. Our investigation shows that PPI score does have positive impact in predicting subcellular protein localization. At high average PPI score of 891, performance accuracy ranges from 0.78 for ‘punctate composite’ to 0.93 for ‘nucleolus’ and at low average PPI score of 169, performance accuracy ranges from 0.60 for ‘cytoplasm’ to 0.83 for ‘mitochondrion’.
Rotational energy levels and line intensities for 2S+1Λ-2S+1Λ and 2S+1(Λ ± 1)-2S+1Λ transitions in a diatomic molecule van der Waals bonded to a closed shell partner

Abstract Hamiltonian matrix elements needed for calculating rotational energy levels are derived for a planar complex consisting of an open-shell diatomic molecule and a closed-shell partner. These matrix elements take account of spin-orbit interaction and a Renner-Teller-like splitting term, but not of the effects of large-amplitude internal rotation of the diatomic fragment within the complex. Rotational levels obtained by numerically diagonalizing this Hamiltonian matrix for given J are, as expected, strongly influenced by the degree of quantization of projections of the electron orbital, electron spin, and total angular momentum along the two natural axes in the problem, i.e., by the degree of quantization along the internuclear axis of the open-shell diatomic fragment, or along the inertial a axis of the near-symmetric-top planar complex. The degree of quantization of these varioss projections is in turn determined by the relative sizes of the spinorbit interaction, the Renner-Teller interaction, and products of the rotational constants and quantum numbers of the form BJ , CJ , and AK , as well as by the angle between the diatomic internuclear axis and the inertial a axis of the complex. Transition-moment matrix elements needed for calculating intensities in spin and orbitally allowed transitions in the open-shell diatomic fragment are also derived. Such transitions have the form 2 S +1 Λ- 2 S +1 Λ and 2 S +1 (Λ ± 1)- 2 S +1 Λ, where Λ = Σ, Π, Δ, Φ, etc. A brief discussion of how to use the Hamiltonian and transition-moment matrix elements in a computer program is given.
Estimating models of labor market transitions based on alternative specifications of job search theory

Abstract In this paper, a model of job transitions based on job search theoretic arguments is specified and estimated. Because job search theory has implications for the optimal stopping rule followed, over time, by an unemployed individual, it also has implifications for the distribution of unemployment/job spells duration. Typically, stationary models predict that individual labor market histories are governed by a Markov process. The model analyzed here, allowing for nonstationarity and duration dependence in unemployment, predicts that the transition rate out of a current job may depend on the completed duration in the previous state (unemployment). The results show that the semi-Markov property is too restrictive and may therefore cause the loss of economic information that may help identify the source of nonstationarity.
Modeling Demand Response Capability by Internet Data Centers Processing Batch Computing Jobs

Electricity cost has become a big concern of commercial cloud service providers with the rapid expansion of network-based cloud computing. Locationally, dispersed large-scale Internet data centers (IDCs) that underpin the cloud have increasing impact on the regional electricity market with their skyrocketing energy consumption. In this paper, the electricity market participation and accordingly the demand response capability of an IDC is defined as its temporally and spatially shiftable electricity demand quantities for processing delay-tolerant central processing unit-intense batch computing jobs. The demand response capability of the IDC is obtained by the proposed electric demand management solution. Price-sensitive and cooling efficiency-enabled batch computing workload dispatch with the objective of minimizing electricity cost is realized by dynamic IDC server consolidation and scheduling with virtual machine live migration technology. Numerical simulations show the effectiveness of the proposed demand management solution in IDC energy consumption and electricity cost reduction.
Effect of Scopolamine on the Cerebral Accumulation of 14C-Catecholamines from 14C-Tyrosine

The effect of the anti-muscarinic and psychotomimetic agent, scopolamine, on the accumulation of 14C-catecholamines formed from 14C-tyrosine administered intra-cerebrally to the
In Silico Analysis of Disease-Association Mapping Strategies Using the Coalescent Process and Incorporating Ascertainment and Selection

We present a new method for simulating samples of marker haplotypes, genotypes, or diplotypes in case-control studies in which the markers are linked to a disease locus in any specified region of the genome. The method allows realistic features to be incorporated into the simulations, including selection acting on disease alleles, sample ascertainment of disease chromosomes and polymorphic markers, a genetic dominance model of disease expression that allows incomplete penetrance and phenocopies, and an accurate genetic map of recombination rates and hotspots for recombination in the human genome (or, alternatively, an improved method for simulating the distribution of hotspots). The new method uses an approach that combines simulation of the coalescent process for the sampled chromosomes with a diffusion process used to model the evolution of the disease-mutation frequency over time. Examples illustrate how the method may be used to study the expected power of a marker-disease association study.
Construction of the Tetracyclic Skeleton of Leucothol A. 1,2,4a,5,6,7,8,9,10,10a,11,11a-Dodecahydro-11-hydroxy-11-methyl-7-phenylthiomethyl-5aH-5a,8-methanocyclohepta[b]naphthalen-10-one

The title compound, C24H30O2S, is a tetracyclic intermediate for the synthesis of leucothol A and the first example of an ethanoanthracene skeleton to be synthetized. The single-crystal X-ray structure of this compound is presented.
Coupling thermal field-flow fractionation with matrix-assisted laser desorption/ionization time-of-flight mass spectrometry for the analysis of synthetic polymers.

Thermal field-flow fractionation (ThFFF) and matrix-assisted laser desorption/ionization time-of-flight mass spectrometry (MALDI-TOFMS) have been coupled to yield a powerful combination of techniques for polymer analysis. Thermal FFF's high molecular weight (MW) selectivity and sensitivity to chemical composition are used to separate polydisperse polymers and polymer mixtures into the narrow polydispersity and homogeneous chemical composition fractions essential for MALDI-TOFMS analyses. On the other hand, MALDI-TOFMS's ability to directly measure molecular weight alleviates the need for polymer standards for ThFFF. In this first-time coupling of ThFFF and MALDI-TOFMS, compatibility issues were addressed and optimum conditions and procedures were identified and developed to maximize the capabilities of the combined technique. Depending on the polymer MW and the method of MALDI sample deposition, fractions from 1−10 ThFFF runs were combined for MALDI-TOFMS analysis. Binary solvents were used to enhance ThF...