cssi/SciSciGPT-SciSciNet huggingface dataset:
Interpretive phenomenological analysis of a lawsuit contending that school-based yoga is religion: A study of school personnel

Abstract This study focused on the perspectives of school personnel affiliated with the Encinitas Union School District in California following a lawsuit arguing that their yoga-based program included religion and therefore was unsuitable for implementation in public schools and was unconstitutional. Participants (N = 32) were interviewed using a semistructured interview, and data were analyzed according to Interpretative Phenomenological Analysis. Five super-ordinate themes (including sub-themes) were identified in an iterative process, including: participants' perspectives on the roots of yoga and the type of yoga taught in their district; the process of introducing a yoga-in-the-schools program in light of this contention (including challenges and obstacles, and how these were met); perspectives on the lawsuit and how the process unfolded; effects of the lawsuit on school climate and beyond; and perspectives on yoga as, and as not, religious. The study attempts to shed light on the impact of an ongoing...
Extending julius seizure, a bang-sensitive gene, as a model for studying epileptogenesis: Cold shock, and a new insertional mutation

The bang-sensitive (BS) mutants of Drosophila are an important model for studying epilepsy. We recently identified a novel BS locus, julius seizure (jus), encoding a protein containing two transmembrane domains and an extracellular cysteine-rich loop. We also determined that jussda iso7.8, a previously identified BS mutation, is an allele of jus by recombination, deficiency mapping, complementation testing, and genetic rescue. RNAi knockdown revealed that jus expression is important in cholinergic neurons and that the critical stage of jus expression is the mid-pupa. Finally, we found that a functional, GFP-tagged genomic construct of jus is expressed mostly in axons of the neck connectives and of the thoracic abdominal ganglia. In this Extra View article, we show that a MiMiC GFP-tagged Jus is localized to the same nervous system regions as the GFP-tagged genomic construct, but its expression is mostly confined to cell bodies and it causes bang-sensitivity. The MiMiC GFP-tag lies in the extracellular loop while the genomic construct is tagged at the C-terminus. This suggests that the alternate position of the GFP tag may disrupt Jus protein function by altering its subcellular localization and/or stability. We also show that a small subset of jus-expressing neurons are responsible for the BS phenotype. Finally, extending the utility of the BS seizure model, we show that jus mutants exhibit cold-sensitive paralysis and are partially sensitive to strobe-induced seizures.
Toxicity of Androgen Deprivation Therapy in Hormone-Sensitive Prostate Cancer

Androgen deprivation therapy for prostate cancer is one of the most effective types of systemic therapies in solid tumor malignancies and represents one of the first examples of “targeted therapy.” However, we have become increasingly aware of the adverse events associated with androgen deprivation therapy. Some of these side effects can have deleterious effects on quality of life, and others may contribute to increased risks for serious health concerns. Vasomotor toxicity (hot flashes) and sexual side effects are among the most well-recognized adverse effects. Additional toxicities related to the metabolic effects include bone and muscle changes, lipid and glucose metabolic changes, and cognitive changes, which are important to recognize. Physicians should be aware of profound effects of ADT and should incorporate strategies for preventing, identifying, and managing toxicities into routine practice. This chapter reviews the incidence and mechanism of each group of toxicities and discusses the potential primary and secondary therapeutic possibilities.
Controlled Interphases in Glass Fiber and Particulate Reinforced Polymers: Structure of Silane Coupling Agents in Solutions and on Substrates

The structure of silane coupling agents in solution and on solid substrate is reviewed with special emphasis on the fundamentals of structural development. Factors affecting the molecular weight, adsorption behavior, and chemical bond formation are discussed. Molecular aspects of the reinforcement mechanisms are discussed in relation to the interfacial bond formation. Effects of surface treatment on the rheological and hydrothermal properties of filled systems and composites are described.
Development of an Interferon-Based Cancer Vaccine Protocol

A protocol for the development of cancer vaccines is presented. The protocol is based upon the long-term in vitro treatment of cancer cells with interferon (IFN)-alpha to create cancer vaccine cells. This protocol has been used to develop cancer vaccines in mice against B16 melanoma, RM-1 prostate cancer, and P388 lymphocytic leukemia. A detailed description of the protocol is presented. Important considerations that are discussed include the method of selection of potential cancer vaccine cells that would make good models for cancer vaccines for human cancers, the effects of in vitro IFN-alpha treatment concentration on the efficacy of generated cancer vaccine cells, the differential ability of cancer cells to become efficacious cancer vaccine cells in response to IFN-alpha treatment, the determination of the effectiveness of ultraviolet-light killing of various cancer cell types for generating cancer vaccine cells, and the methods of evaluation of statistical significance of the data obtained. Potential problems also are addressed.
Influence of 5-HT2A receptor blockade on phrenic nerve discharge at three levels of extracellular K+ in arterially-perfused adult rat.

Recent observations from in vitro rodent preparations suggest an important role for the serotonin-2A (5-HT2A) receptor in eupneic (basal) and gasping respiratory activities, although the precise role appears to be different in different preparations. Since these in vitro preparations are typically supplied with elevated (and different) levels of K+ to increase neuronal excitability, the role of endogenous activation of 5-HT2A receptors in these respiratory behaviors under “normal” levels of extracellular K+ ([K+]o) requires clarification. The current study sought to evaluate the influence of [K+]o on the 5-HT2A receptor-mediated effects on basal respiratory activity and the phases of the hypoxic ventilatory response (HVR), including ischemia-induced gasping in an arterially-perfused adult rat preparation. Our data demonstrate that at each level of [K+]o examined, blockade of 5-HT2A receptors increases basal phrenic burst frequency, decreases basal phrenic burst amplitude, alters basal phrenic burst pattern, and eliminates the phases of the HVR. These data support an important role for 5-HT2A receptors in respiratory control, and indicate the their role is not dependent on the level of [K+]o.
The End of Roman Juristic Writing

I first met Reuven Yaron in 1958, and we immediately became fast friends. The friendship with him and Shoshana has deepened over the years, and will continue. He and I have frequently read one another's draft papers. I thank him for many years of intellectual and emotional support, and hope he will take pleasure in this offering that he has had no possibility of criticising in advance. The traditional date for the end of classical Roman law is 235 when the emperor Alexander Severus was murdered, or slightly later with the death of Modestinus, the last of the great known jurists. Thereafter, few original juristic books were written, and it is widely but not universally believed that a decline in legal standards began almost at once. For many scholars there seems to exist a connection, sometimes simply implicit, between the failure of jurists to write new books, and a decline in legal standards. I should like to suggest there was a different reason for jurists ceasing to write new law books. They had already written them all! The claim that for the period, say fifty years, after around 235, all the law books had already been written seems extreme, but is easy to substantiate.
Computational Translation of Nonmammalian Species Data to Mammalian Species to Meet REACH and Next Generation Risk Assessment Needs

New concepts in toxicology facilitate the use of nonmammalian vertebrate species (e.g., fish) and nonanimal models (nonvertebrates, early embryo vertebrates, or cell-based) as surrogates for mammals. We present a strategy to translate nonmammalian species data to estimate potential impact of chemicals on mammalian species based on highly conserved proteins and biological pathways linked to a defined adverse effect. Protein “targets” and pathway-level information can be mapped across species through identification of orthologs in mammals. Nonmammalian pathway data can be used to identify potential modes of action across species, establish toxicological dose-response relationships, and be used to estimate possible hazard levels of chemicals. Systems-level approaches are identified that offer unique opportunities to incorporate dynamic events such as homeostasis, effects over time, and species-specific parameters relevant to mammals. Ultimately, a pathway-centric focus enables use of alternative models to support protection of mammalian species.
Social Media and Employee Selection: Literature-Based Expectations of Adverse Impact

Social media (SM) has become pervasive in our society and is increasingly used by organizations to help inform staffing decisions. Despite organizations' rapidly expanding use of SM, there has been...
Integrated Synthetic Fourth-Order $Q$ -Enhanced Bandpass Filter With High Dynamic Range, Tunable Frequency, and Fractional Bandwidth Control

This paper demonstrates a tunable synthetic fourth-order bandpass filter (BPF) at microwave frequencies. Two parallel second-order Q-enhanced LC BPFs responses are added with the out of phase to synthesize a fourth-order BPF response. The filter is implemented in a 130-nm SiGe BiCMOS technology with a core die area of $0.53 \times 0.7$ mm2. The filter center frequency can be tuned from 4 to 8 GHz (C-band). The filter also achieves a wide 3-dB fractional bandwidth (BW) tuning range of 2%–25%, with a passband ripple of less than 0.5 dB. The corresponding normalized dynamic range (DR) is 151–166 $\text {dB}\cdot \text {Hz}$ owing to a switched varactor control scheme to realize a large effective tuning range with high linearity. Using the parallel synthesis approach, the filter can maintain the DR of a second-order BPF while achieving a fourth-order frequency selectivity, which is favorable compared to cascading resonators. On the lower side of the band, the filter achieves more than 65 dB of ultimate rejection. On the upper side, the rejection is more than 52 dB. The filter also employs a variable transconductor for noise-linearity tradeoff flexibility. The power consumption of the filter is 112–125 mW over the above fractional BW tuning range at the target C-band.
Editorial: IEEE Transactions on Sustainable Computing , Special Issue on Smart Data and Deep Learning in Sustainable Computing

The twelve papers in this special section focus on smart data and deep learning in sustainable computing. We are living in a data-driven era in which numerous infrastructure can be connected and the interconnected systems can perform “smart” when the large pool of the data are well utilized. Finding the way of well utilizing the large volume of data has an urgent demand in multiple realms, including academics, industries, and education. The force behind the data can be pushed out from a variety of data-driven techniques, such as machine learning and deep learning, which is a great potential for generating successful model, framework, and method for achieving sustainable computing. Therefore, gathering recent achievements in smart data and deep learning in sustainable computing is meaningful and valuable for powering the capability of datadriven domain and the various applications, implementations, and innovations in different disciplines and fields. This special issue focuses on two aspects considering the perspective of sustainable computing, which include smart data and deep learning. The smart data covers all dimensions of data usage lifecycles, such as data selections and collections, data preprocessing, data mining, and data analytics, in various application scenarios. The other aspect, deep learning, emphasizes the intelligent performance of applying data-driven techniques in practices and research explorations. Thus, this special issue aims at collecting updated outstanding papers that illustrate the latest achievements and development updates concerning the smart data and deep learning solutions, issues, applications, trends, and implementations in sustainable computing.
Abstract P178: Age-Related Gender and Ethnic Variations of Pulse Pressure and Pulsatile Stress

Background: Aging causes significant widening of pulse pressure (PP), which has been associated with increased incidence of heart failure, especially diastolic with preserved ejection fraction (HFp...
Policy Recommendations to Improve the Quality of Life for LGBT Older Adults

This article explores the increased vulnerability of older lesbian, gay, bisexual, and transgender (LGBT) adults and their needs. Older LGBT adults lack legal protection, which leads to higher rates of discrimination in the work environment, living arrangements, and services. The impact of discrimination against older LGBT adults results in an elevated rate of physical and psychological consequences when compared to the general older population. A brief overview of legal precedence pertaining to the LGBT community is provided, and the needs of older LGBT adults are identified. Social work practice and policy recommendations are highlighted to address identified needs and improve the quality of life for older LGBT adults. A human rights framework is applied to inform all practice and policy recommendations to ensure basic human rights are met, as outlined in the Universal Declaration of Human Rights. The role of the social worker in addressing the needs of older LGBT adults is discussed, as well.
Looking to the Future—Aging in Place

While previous chapters have summarized why people move to senior cohousing and their subsequent experiences, this chapter will examine how senior cohousing residents see their future as they age within the community. An important issue brought up in numerous conversations was ability to receive and give support. This chapter will summarize thoughts and hopes of residents as they look into coming years.
STRUCTURES AND ENERGETICS OF HYDROCARBON MOLECULES IN THE WIDE HYDROGEN CHEMICAL POTENTIAL RANGE

We report a collection of lowest-energy structures of hydrocarbon molecules CnHm (n = 6-18, m = 0 - 2n + 2) within the wide hydrogen chemical potential range. The genetic algorithm combined with Brenner's empirical potential is applied for the search. The resultant low-energy structures are further examined by ab initio quantum chemical calculations. The lowest-energy molecules with several additional low-energy structures are classified to four groups according to their structural motifs and the phase diagram with respect to carbon atom number and hydrogen chemical potential is presented. The results provide useful information for identifying the hydrocarbon molecules in the interstellar medium as well as addressing the hydrocarbon-related nanofragment growth in experiments.
Five new ternary indium-arsenides discovered. Synthesis and structural characterization of the Zintl phases Sr3In2As4, Ba3In2As4, Eu3In2As4, Sr5In2As6 and Eu5In2As6

Abstract Five new ternary indium aresenides, AE3In2As4 (AE = Sr, Ba, Eu), and AE5In2As6 (AE = Sr, Eu), have been synthesized using molten metal In, Pb, and Sn fluxes. Structure elucidation was aided by powder X-ray and single crystal X-ray diffraction. This revealed Sr3In2As4 and Eu3In2As4 are orthorhombic and isostructural to Sr3In2P4 (space group Pnnm, Z = 2), while Ba3In2As4 is monoclinic and isostructural to Ca3Al2As4 (space group C2/c, Z = 4). In addition, Sr5In2As6 and Eu5In2As6 crystallize orthorhombically and adopt the Ca5Ga2As6 structure type (space group Pbam, Z = 2). The valence electron count for all structures conform to the Zintl-Klemm concept, and as such can be rationalized as divalent Sr, Ba, Eu cations and polyanionic In–As fragments of different dimensionality. In Sr3In2As4 and Eu3In2As4, one-dimensional chains [In2As4]6– running along the crystallographic c-axis exist, and they are made up of edge- and corner-shared tetrahedra InAs4. The [In2As4]6– two-dimensional sheets in the structure of Ba3In2As4 are composed of a pair of edge-shared InAs4 tetrahedra, that are further connected by corner-sharing. In Sr5In2As6 and Eu5In2As6, the InAs4 tetrahedra are only corner-shared to make infinite [InAs2As2/2]6– chains running along the a-axis, which are dimerized via As–As bonds into [In2As6]10− ribbons. Electronic structure calculations affirm these assignments and suggest intrinsic, narrow-gap seminconducting behavior.
Inflammatory cell predominance and patterns in chronic rhinosinusitis with and without nasal polyposis patients

Objectives There is interest in identifying chronic rhinosinusitis (CRS) endotypes that align pathophysiology with clinical observation and outcomes. CRS with polyps (CRSwNP) has classically been studied with reference to tissue eosinophilia, but the role of other cellular infiltrates remains uncharacterized. No particular tissue prognosticators have been described for CRS without nasal polyps (CRSsNP). Predominance of leukocytes seen in surgical tissue may be useful for differentiating CRS subtypes, severity of inflammation, and outcomes. Methods Structured histopathology reports were examined for 277 patients undergoing endoscopic sinus surgery for CRSwNP (n = 115), CRSsNP (n = 141), and recurrent acute rhinosinusitis (RARS, n = 21). Inflammatory predominance was examined for associations with nasal polyposis, asthma, allergic rhinitis, aspirin exacerbated respiratory disease (AERD), immune deficiency, preoperative Lund-Mackay score, and outcome (SNOT-22 score change). Results In order of frequency, the prevalence of predominant inflammatory patterns accounting for 93.5% of CRS patients were: lymphoplasmocytic (n = 111), lymphocytic (n = 74), eosinophilic (n = 50), and lymphoplasmocytic with eosinophilic (n = 24). Eosinophilic predominance was 97.4% specific for nasal polyps (95% confidence interval [CI], 93.4%-99.3%), although sensitivity was 43.4% (95% CI, 33.8%-53.4%). The absence of eosinophilic predominance was 100% sensitive for RARS (95% CI, 82.4%-100%), however specificity was 30.8% (95% CI 25.1%-37.1%). There were no significant differences in preoperative SNOT-22 scores or change postoperatively. Conclusions Eosinophilic inflammatory predominance was predictive for nasal polyps and against RARS. Nevertheless, the majority of CRSwNP patients had a different inflammatory predominance, demonstrating heterogeneity in CRS, even among patients with nasal polyps. Symptomatic outcomes were not associated with inflammatory predominance through 12 months follow up. Level of evidence 4.
Quantifying Atmospheric Trace Element Deposition Over the Ocean on a Global Scale With Satellite Rainfall Products

Atmospheric input of trace element micronutrients to the oceans is difficult to determine as even with collection of high-quality aerosol chemical concentrations such data by themselves cannot yiel...
PPTP VPN: An Analysis of the Effects of a DDoS Attack

Personal Point-to-Point (PPTP) Virtual Private Network is widely used in small businesses and operations using legacy systems. In this paper, a default VPN gateway is set up and configured for a Direct Access PPTP VPN on a Windows Server 2016 machine running Routing, Remote Access, and Active Directory to permit Windows 10 client connectivity. Then a client is configured to connect remotely to this VPN over a network. On this same network, four Kali Linux machines are attacking the client with an Hping3 Denial-of-Service attack, which floods the client with packets to disrupt the service. In doing this, it is shown how the VPN itself handles the attack and what it does to protect the user from further attacks. While the client is under attack, it is found that the VPN would not establish a connection. Additionally, if the client is already connected to the VPN and is attacked, the VPN disconnects the client. This is accompanied by near-complete network instability and packet loss which correlates to the notorious insecurity of PPTP and explains why other protocols have become more widely implemented.
Improvised songs of praise and group sociality in contemporary Chinese banquet culture

In China, banquets are an important means of maintaining and negotiating social relationships. Based on fieldwork conducted with professional folksingers in Shaanxi Province and the Ordos region of Inner Mongolia from 2006 to 2011, this article examines how for-hire folksingers who perform improvised songs for guests at banquets play into the promotion of group solidarity. Building on research about socialization strategies in Chinese banquets and the social effects of publicly-performed praise songs, this article examines the use of oral formulae, some of which describe individuals by referencing recognizable archetypes of shared acclaim, such as successful officials, brilliant scholars, and beautiful women. When integrated with toasting rituals common to banquets across China, such archetypes are mobilized to promote the social connections (guanxi) that are an important goal in Chinese banquet culture, positioning the assembled guests as a cohesive group of distinct individuals in a manner that avoids potential competition in favor of strengthening social ties.
Adapting a contact-mechanics algorithm to predict damping in bolted joints using quasi-static modal analysis

Abstract While a bolted joint can be modeled in commercial FE codes, even quasi-static analysis is extremely expensive due to the level of detail required to capture slip at the bolt interface. This is even worse for 3D cases where the solver must deal with the two-dimensional friction problem, making convergence more expensive. In order to address this issue, we present a quasi-static algorithm that greatly accelerates the analysis of 2D and 3D problems. This algorithm uses static reduction along with a new numerical method which is a hybrid between Block-Gauss-Seidel and Newton-Rhapson. A relaxed form of 2D frictional problem is presented in this algorithm which increases the efficiency of the method. In order to evaluate the performance of the algorithm, we apply the method to perform QSMA on 2D and 3D cases. QSMA uses a series of static loadings to predict the effective natural frequency and damping of each mode of a bolted structure as a function of vibration amplitude. In the cases studied here the algorithm resulted in dramatic computational savings while providing good accuracy as compared to simulations in commercial finite element software, both for the effective natural frequencies and damping and for the contact pressure distributions. To explore the robustness of the algorithm, the mesh density, preloads, and quasi-static force amplitudes are explored. The effect of the size of the reduced model on the accuracy of the result and the efficiency of the method is investigated in this paper.
Neural Responses to a Putative Set-shifting Task in Children with Autism Spectrum Disorder

While much progress has been made toward understanding the neurobiology of social and communication deficits associated with autism spectrum disorder (ASD), less is known regarding the neurobiological basis of restricted and repetitive behaviors (RRBs) central to the ASD diagnosis. Symptom severity for RRBs in ASD is associated with cognitive inflexibility. Thus, understanding the neural mechanisms underlying cognitive inflexibility in ASD is critical for tailoring therapies to treat this understudied yet pervasive symptom. Here we used a set-shifting paradigm adopted from the developmental cognitive neuroscience literature involving flexible switching between stimulus categories to examine task performance and neural responses in children with ASD. Behaviorally, we found little evidence for group differences in performance on the set-shifting task. Compared with typically developing children, children with ASD exhibited greater activation of the parahippocampal gyrus during performance on trials requiring switching. These findings suggest that children with ASD may need to recruit memory-based neural systems to a greater degree when learning to flexibly associate stimuli with responses. LAY SUMMARY: Children with autism often struggle to behave in a flexible way when faced with unexpected challenges. We examined brain responses during a task thought to involve flexible thinking and found that compared with typically developing children, those with autism relied more on brain areas involved in learning and memory to complete the task. This study helps us to understand what types of cognitive tasks are best suited for exploring the neural basis of cognitive flexibility in children with autism. Autism Res 2020, 13: 1501-1515. © 2020 International Society for Autism Research, Wiley Periodicals, Inc.
Abstract 4809: Monoethanolamine stimulates calcium-induced metabolic stress leading to autophagic cell death in prostate cancer

Mitochondrial activity and metabolism are crucial to meet the energy demands of cancer cells. We have recently shown the efficacy of monoethanolamine (Etn), an orally deliverable lipid formulation, in reducing tumor growth in various xenograft models including prostate cancer (PCa). Etn increased the metabolic stress of PCa cells by depleting cellular glucose and glutamine levels. However, the precise mechanism of Etn-mediated metabolic stress in cancer cells remains elusive. Herein, we examined how Etn alters the activity and structure of the mitochondria to induce cell death. Etn treatment modulated phosphatidylethanolamine (PE) lipid and glycerophosphoethanolamine (GPE) levels in PCa cells. Altered PE lipids correlated with disruption of mitochondrial cristae and led to a concomitant accumulation of autophagosomes. Deregulated functional activity of mitochondria, as evidenced by reduced oxygen consumption rate (OCR), extracellular acidification rate (ECAR), were associated with structural distortions of the mitochondria and a transient increase in the intracellular calcium concentration. Etn treatment reduced the amount of cytosolic lipid droplets (LD) and caused a reduction in PE/GPE ratio. Further, we observed an increase in lipolysis and death-inducing autophagy activation in Etn-treated PCa cells. These data suggest that Etn is a promising anticancer agent for PCa and further studies to determine its efficacy in other cancer types are warranted. Citation Format: Chakravarthy Garlapati. Monoethanolamine stimulates calcium-induced metabolic stress leading to autophagic cell death in prostate cancer [abstract]. In: Proceedings of the Annual Meeting of the American Association for Cancer Research 2020; 2020 Apr 27-28 and Jun 22-24. Philadelphia (PA): AACR; Cancer Res 2020;80(16 Suppl):Abstract nr 4809.
Space–time reduced order model for large-scale linear dynamical systems with application to Boltzmann transport problems

Abstract A classical reduced order model for dynamical problems involves spatial reduction of the problem size. However, temporal reduction accompanied by the spatial reduction can further reduce the problem size without losing much accuracy, which results in a considerably more speed-up than the spatial reduction only. Recently, a novel space–time reduced order model for dynamical problems has been developed [17] , where the space–time reduced order model shows an order of a hundred speed-up with a relative error of 10 − 4 for small academic problems. However, in order for the method to be applicable to a large-scale problem, an efficient space–time reduced basis construction algorithm needs to be developed. We present the incremental space–time reduced basis construction algorithm. The incremental algorithm is fully parallel and scalable. Additionally, the block structure in the space–time reduced basis is exploited, which enables the avoidance of constructing the reduced space–time basis. These novel techniques are applied to a large-scale particle transport simulation with million and billion degrees of freedom. The numerical example shows that the algorithm is scalable and practical. Also, it achieves a tremendous speed-up, maintaining a good accuracy. Finally, error bounds for space-only and space–time reduced order models are derived.
Time resolved plasma characterization in a long conduction time planar plasma opening switch

A system with circuit characteristics much like the US Naval Research Laboratory's POP experiment has been constructed. The system has an inductance of 300 nH (no plasma in switch, short-circuit load) with 10 nH of this downstream of the POS. The system is pulsed by a 1.9- mu F Scyllac capacitor charged to 50 kV. A Mendel-type carbon plasma gun supplies a plasma with roughly 3*10/sup 14/ cm/sup -3/ ion density, predominantly C/sup ++/, with an electron temperature of 10-15 eV. A recently completed run with this switch plasma gave conduction times up to 400 ns, with an opening time of 130 ns, delivering 70 kA (out of 106 kA available) into a short-circuit load. An electron-beam-diode load gave 220-ns conduction time and 190-ns opening time with 70 kA (out of 100 kA available) delivered to the diode with some voltage multiplication. Additional experiments were conducted in which the plasma dynamics and properties were monitored in detail before and during opening. >
Presence of estrogen and progesterone receptors in proliferating and involuting infantile hemangiomas.

Summary Background Studies in the literature have demonstrated the presence of sex hormone receptors in infantile hemangiomas (IHs), but further investigation is needed to determine the role of these receptors in their proliferation and involution. To date, there are no studies in the literature that aimed to quantitatively examine the expression of sex hormone receptors throughout the different phases of hemangioma development. Objective The objective of our study was to quantitatively evaluate the expression of estrogen (ER) and progesterone (PR) receptors in the proliferative and involuting phases of IHs through the use of real-time polymerase chain reaction (RT-PCR). Methods Twenty IHs (10 proliferating and 10 involuting) were harvested and prepared for molecular investigation. ER receptor alpha (ERα) and beta (ERβ) and the PR expression were examined by RT-PCR and western blot. Results RT-PCR analysis demonstrated that mRNA expression of ERα, ERβ, and PR was significantly lower in proliferating versus involuting IH. Western blot analysis revealed increased protein expression of ERα in involuting hemangiomas as compared to proliferating ones. Conclusions Our study demonstrates the variable expression of ER and PR receptors in proliferating and involuting hemangiomas. Further studies are needed to determine the exact role of these hormone receptors in the growth and involution of IHs.
Parasitic Fungi of Illinois: Part I. Uredineae

Most of the plants herein described were collected in Illinois during 1881 and 1882. by Mr. A. B. Seymour, who was employed for the purpose by the Illinois State Laboratory of Natural History. The entire collection consists of three thousand seven hundred and eighty-four numbers, many of which are of course duplicates, or are different stages of the same species, leaving, however, a very large number of distinct specific forms—much larger than is usually supposed to exist in our flora. The determinations have been made at the Illinois Industrial University by myself, efficiently aided by Mr. Seymour. For this work, besides the facilities offered by the library and herbarium of the University, the State Laboratory of Natural History furnished many books and specimens. Among the latter are the following sets of exsiccata: DeThumen's Mycotheca Universalis, Ellis' North American Fungi. Ravenel's Fungi Caroliniani and Fungi Americani.
Dasatinib-induced diffuse alveolar hemorrhage

The BCR-ABL tyrosine kinase inhibitor dasatinib is a potent treatment for chronic myeloid leukemia (CML). However, it is associated with pulmonary toxicities. Commonly reported dasatinib related pulmonary toxicities include pleural effusion, lung parenchymal abnormalities, and pulmonary hypertension. Diffuse alveolar hemorrhage (DAH) during treatment with dasatinib is very rare. To the best of our knowledge there are only two cases reported. Here we report a 57-year-old Caucasian woman who developed acute hypoxic respiratory failure while on dasatinib for treatment of CML. She was diagnosed with DAH suspected to be secondary to dasatinib, after other common etiologies were ruled out. There was full recovery after stopping dasatinib and treatment with corticosteroids. Keywords: Dasatinib, pulmonary toxicity, diffuse alveolar hemorrhage, chronic myeloid leukemia
The Psychodynamics of Peace

This chapter explores the possible contributions of psychoanalytic theory to sustainable peace. The chapter traces the development of psychoanalysis from a drive-based theory to a relational one, and the implications of both constructs to group and intergroup dynamics relevant to sustainable peace. Whereas the former involves the management of potentially destructive group defenses stemming from the struggle to contain the aggressive drive, the latter focuses on the employment of empathy and the developmental processes of separation-individuation and internalization. The roles of healthy and unhealthy narcissism, mirroring, mourning, and secondary aggression are also explored. Finally the chapter discusses some the future implications and practical applications of the concepts presented.
Heart rate variability in pediatric obstructive sleep apnea.

Obstructive sleep apnea syndrome (OSAS) is observed in approximately 2% of children. Heart rate vari- ability (HRV) is a potentially simple, non-invasive diagnostic screening tool for OSAS. In this study, we investigated the diagnostic potential of HRV using power spectral analysis, numerical titration, sample entropy, and detrended fluctuation analysis. Effects of sleep stages (REM and NREM sleep) are evaluated. The results show that the heart rate chaos intensity, as measured by the noise limit in numerical titration, is significantly higher during REM sleep than NREM sleep in all patient groups. By using the receiver-operating characteristic analysis, the detection of OSAS yielded a specificity of 72.2% and sensitivity of 81.3% using the numerical-titration technique. The findings suggest that sleep state and disordered breathing are important determinants of cardiac autonomic control. Nonlinear techniques such as numerical titration, when used in conjunction with spectral analysis of HRV could be an effective screening tool for pediatric OSAS.
Identification of a patient withStreptococcus pneumoniaebacteremia and meningitis by the polymerase chain reaction (PCR)

Abstract A polymerase chain reaction (PCR) assay based on the penicillin-binding protein gene PBP2B identified the presence of DNA specific for Streptococcus pneumoniae in the serum and CSF of a patient with culture-proven bacteremia and meningitis. Positive signals were seen to dilutions of 1:125 and 1:390,625 for the blood and CSF specimens, respectively. Potential advantages of PCR over conventional culture include exquisite sensitivity, faster results and the ability to identify the organisms by the presence of species-specific DNA even in patients pretreated with antibiotics.
SPR Design using Feedback

In this paper we derive necessary and sufficient conditions for a square transfer matrix to be rendered Strictly-Positive-Real (SPR) using output feedback. These conditions are then related to the existence of stable inverse systems.
Maturation cérébrale à l’adolescence : vulnérabilité comportementale

Recent neurodevelopmental research has been focusing on the transition period of adolescence into adulthood. This growing interest was spurred by the long-standing realization of the high cost of this transition period in terms of morbidity and mortality, and the emergence of research tools that permit direct examination of brain function in humans. The cost of reaching adulthood is understood as resulting from the typical behavioral and environmental changes that accompany adolescence 4. The present review describes how the current research helps formulate neurobiological models that can be used to guide future work. One example of such a model, the triadic neural systems model 8., will be examined in more detail. This review will proceed in three stages. First, we will show how neural development results from the confluence of maturational changes that are quantitatively and qualitatively heterogeneous across brain regions, neurochemical and molecular systems. This normative developmental heterogeneity is translated into typical adolescent behavioral patterns, including risk-taking, novelty-seeking, emotional intensity and lability, and peer-group social primacy 5, 9. Second, based on the notion that motivated behavior can be operationally decomposed into the three core modules of approach, avoidance and control, any alteration in the balance of these three core entities can affect behavior in unique ways. This formulation will serve as the foundation of the neural systems model framework proposed in this review. Third, functional neuroimaging is being used to examine how neural systems underlie this balance within the neural systems model. We will provide a summary of the state of research in this area. Finally, we will show how this research is important for understanding not only normal development, but also the psychopathology. The role of genetic or environmental factors will not be addressed here, despite their critical roles in determining and modulating the balance among the nodes of the triadic model. Language: fr
Synthesis of [15, 16-3H] beta-funaltrexamine

Beta-funaltrexamine is a unique irreversible antagonist for the mu-opiate receptor and would be useful as a tritiated radioligand. Starting from high specific activity [15, 16-³H] naltrexone, [15, 16-³H] beta-funaltrexamine was synthesized and characterized by means of a two-step reductive amination-acylation process.
Identification of a Zinc-Specific Metalloregulatory Protein, Zur, Controlling Zinc Transport Operons in Bacillus subtilis

Despite the essential role of zinc as a structural and catalytic cofactor in numerous metalloproteins, mechanisms of zinc homeostasis in bacteria are poorly understood (33, 34). As for other essential metal ions, it is likely that both the uptake and efflux of zinc are tightly regulated in response to availability. Zinc uptake and efflux proteins have recently been identified in several bacteria, including Streptococcus pneumoniae (11), Haemophilus influenzae (21), Staphylococcus aureus (40), Synechocystis strain PCC 6803 (38), and Escherichia coli (3, 28, 30). Expression of these transporters, where known, seems to be regulated by zinc-sensing metalloregulatory proteins (28, 38). Metalloregulatory proteins sense the intracellular levels of specific metal ions and mediate a transcriptional or translational response. For example, the E. coli ferric uptake repressor (Fur) protein regulates the iron-dependent repression of iron uptake pathways (2) and is the prototype for a large family of regulators (17). Remarkably, Bacillus subtilis contains three distinct Fur homologs (5). Although many Fur homologs regulate iron uptake, Fur-like regulators control other functions as well. A B. subtilis Fur homolog designated PerR regulates the peroxide stress response (5), while E. coli Zur controls the transcription of a zinc uptake operon (28). Zinc-specific metalloregulation has been documented for yeast, mammals, and bacteria. Much of this work has centered on the induction of metallothionein by zinc. For example, a zinc-sensitive inhibitor protein prevents the interaction of MTF-1 with metal response elements preceding mammalian metallothionein genes (27). In Synechococcus, metallothionein expression is induced when the SmtB repressor dissociates from its operator in response to zinc (8, 14, 39). A similar repressor, ZiaA, regulates the zinc-inducible expression of a zinc efflux pump in Synechococcus strain PCC 6803 (38). The regulation of zinc transport in Saccharomyces cerevisiae has also been well characterized. In that organism, Zap1p activates the transcription of both low- and high-affinity zinc transporters under conditions of zinc limitation (13). Here we describe a B. subtilis Fur homolog, Zur, that regulates two operons implicated in zinc transport. Zur mediates the zinc-dependent repression of the ycdH-containing operon, encoding a putative high-affinity zinc transport system, and yciC, encoding an integral membrane protein of unknown function.
Winning Through Integrity and Professionalism

This article, a reprint of a piece that appeared in the Advocate (Bronx County Bar Journal) in 2009, argues that the best way for a lawyer to win in court is by having integrity and being a professional.
Perceptual Qualities of Ethanol Depend on Concentration, and Variation in These Percepts Associates with Drinking Frequency.

Ethanol, the pharmaceutically active ingredient in all alcoholic beverages, elicits multiple percepts including sweet, bitter, drying, and burning. However, quality-specific perceptual dose-response functions have not been previously reported. Also, individual differences in ethanol perception may associate with differences in alcoholic beverage use. Here, we describe the chemosensory profile of ethanol across concentrations in a convenience sample of mixed-age adults; secondarily, we explore whether individual differences in various qualities from ethanol associate with alcohol use behaviors. Participants (n = 100, 33 men) aged 21 to 55 (mean 33 years) tasted ethanol in water (4, 8, 16, 32, and 48 % v/v) and rated sweetness, bitterness, drying, and burning/tingling on four general Labeled Magnitude Scales. Demographic question and alcohol use measures (years drinking and reported frequency of drinking occasions) were also collected. Intensity of most qualities increased as a function of ethanol concentration, although the dominant sensation differed with concentration. The dominant sensation for 8 and 16 % ethanol was bitterness (7.4 ± 1.0; 13.5 ± 1.4), whereas for 32 and 48 % ethanol, burning/tingling was the dominant sensation (29.7 ± 2.1; 44.7 ± 2.4). Variation in quality-specific intensities of sampled ethanol explained variability in the reported intake frequency for beer, wine, straight spirits, and number of drinking occasions. The number of years reported drinking (grand mean 10.5 ± 0.8) was not significantly associated with perceptual ratings for sampled ethanol. In a convenience sample of mixed-aged adults, the sensations from suprathreshold ethanol varied by concentration: bitterness dominated at lower concentrations, while burn dominated at higher concentrations. Exploratory analyses also suggest that differences in chemosensory responses across participants may associate with measures of alcohol use.
Avian Remains from Khonkho Wankane, an Urban and Ceremonial Center in the Southern Lake Titicaca Altiplano

The urban and ceremonial center Khonkho Wankane flourished in the southern Lake Titicaca Altiplano region during the Late Formative prior to the rise of Tiwanaku as a dominant urban center. This site yielded an avifaunal number of identified specimens (NISP) = 631, with a minimum of 26 taxa represented among 539 skeletal elements or fragments. A total of 92 egg shell fragments also were recovered. The avifauna inhabited two major ecological zones: Lake Titicaca, its margins/wetlands and other water margins; and the dry Altiplano grassland (or puna). Lake/wetland taxa include Phoenicopterus chilensis (Chilean flamingo), Nycticorax nycticorax (night heron) and multiple taxa in the Order Anseriformes (ducks, geese, etc.) including Chloephaga melanoptera (Andean goose), Anas georgica (yellow-billed pintail), A. flavirostris (speckled teal) and Oxyura jamaicensis (Andean ruddyduck). Also present are Fulica ardesiaca (Andean coot), Gallinago andina (puna snipe), Himantopus mexicanus (black-necked stilt) and Charadrius alticola (puna plover). Puna taxa include Nothoprocta cf. ornata (ornate tinamou), Nothura cf. darwinii (Darwin's nothura), Metropelia sp. (ground doves), Athene cunicularia (burrowing owl), and multiple Passeriformes (songbirds, etc.). Taxa with a cosmopolitan distribution include Falco cf. femoralis (aplomado falcon) and Tyto alba (barn owl). Taphonomic analysis indicates that the avifauna were used in ceremonial contexts, including multiple Falco cf. femoralis burials, and for dietary and possibly tool-making purposes. Other sources of introduction into the site deposits likely include natural mortality of taxa directly inhabiting the site area. These findings are compared to the avifauna recovered from the Formative site of Chiripa along the Lake Titicaca margin, which included a much higher proportion of lake bird fauna. At Khonkho Wankane, the importance of wetland avifauna may have been enhanced by the alteration of the local environment to include qochas, or artificial reservoirs/ponds, and continued despite reliance upon multiple domesticated plant and mammal species. Copyright © 2011 John Wiley & Sons, Ltd.
NORM ONE PROJECTIONS ON BANACH SPACES

This note deals with a small but an important observation of hermitian operators on Banach spaces. It is known that if A is a complex Banach space, B( A ) is the set of all operators on A , and H(B( A )) is the set of all hermitian operators then B( A ) = H(B( A )) + i H(B( A )) implies that A is a Hilbert space. We give a converse of this using norm one projections on A . Mathematics Subject Classification (2000): 46H05, 46J10, 4715, 47B48. Keywords: projections, Banach, banach space, ultra product of an operator, hermitian operators, direct sum of spaces, norm one, Banach algebra, continuous functions, function algebras, normal operators, operators, Brown-McCoy, Brown-McCoy radical, radical, non-0-symmetric near-ring, near-rings, near rings, semisimple, identities, radical classes, invariant ideals, ideals, Banach spaces Quaestiones Mathematicaes 24 (4) 2001, 491–492
Prediction of high frequency gust response with airfoil thickness effects

Abstract The unsteady lift forces that act on an airfoil in turbulent flow are an undesirable source of vibration and noise in many industrial applications. Methods to predict these forces have traditionally treated the airfoil as a flat plate. At higher frequencies, where the relevant turbulent length scales are comparable to the airfoil thickness, the flat plate approximation becomes invalid and results in overprediction of the unsteady force spectrum. This work provides an improved methodology for the prediction of the unsteady lift forces that accounts for the thickness of the airfoil. An analytical model was developed to calculate the response of the airfoil to high frequency gusts. The approach is based on a time-domain calculation with a sharp-edged gust and accounts for the distortion of the gust by the mean flow around the airfoil leading edge. The unsteady lift is calculated from a weighted integration of the gust vorticity, which makes the model relatively straightforward to implement and verify. For routine design calculations of turbulence-induced forces, a closed-form gust response thickness correction factor was developed for NACA 65 series airfoils.