cssi/SciSciGPT-SciSciNet huggingface dataset:
Defining a Hospital Volume Threshold for Minimally Invasive Pancreaticoduodenectomy in the United States.

Importance There is increasing interest in expanding use of minimally invasive pancreaticoduodenectomy (MIPD). This procedure is complex, with data suggesting a significant association between hospital volume and outcomes. Objective To determine whether there is an MIPD hospital volume threshold for which patient outcomes could be optimized. Design, Setting, and Participants Adult patients undergoing MIPD were identified from the Healthcare Cost and Utilization Project National Inpatient Sample from 2000 to 2012. Multivariable models with restricted cubic splines were used to identify a hospital volume threshold by plotting annual hospital volume against the adjusted odds of postoperative complications. The current analysis was conducted on August 16, 2016. Main Outcomes and Measures Incidence of any complication. Results Of the 865 patients who underwent MIPD, 474 (55%) were male and the median patient age was 67 years (interquartile range, 59-74 years). Among the patients, 747 (86%) had cancer and 91 (11%) had benign conditions/pancreatitis. Overall, 410 patients (47%) had postoperative complications and 31 (4%) died in-hospital. After adjustment for demographic and clinical characteristics, increasing hospital volume was associated with reduced complications (overall association P P = .04). Conclusions and Relevance Hospital volume is significantly associated with improved outcomes from MIPD, with a threshold of 22 cases per year. Most patients undergo MIPD at low-volume hospitals. Protocols outlining minimum procedural volume thresholds should be considered to facilitate safer dissemination of MIPD.
PathViewer: Visualizing Pathways through Student Data

Analysis of student data is critical for improving education. In particular, educators need to understand what approaches their students are taking to solve a problem. However, identifying student strategies and discovering areas of confusion is difficult because an educator may not know what queries to ask or what patterns to look for in the data. In this paper, we present a visualization tool, PathViewer, to model the paths that students follow when solving a problem. PathViewer leverages ideas from flow diagrams and natural language processing to visualize the sequences of intermediate steps that students take. Using PathViewer, we analyzed how several students solved a Python assignment, discovering interesting and unexpected patterns. Our results suggest that PathViewer can allow educators to quickly identify areas of interest, drill down into specific areas, and identify student approaches to the problem as well as misconceptions they may have.
Parent Perceptions of Medication Treatment for Preschool Children with ADHD

This study sought to examine parent perceptions of medication use for 151 preschool children (M age = 5.05 years, 78% male, 82% Hispanic/Latino) with or at-risk for ADHD who were medication naive. Parents completed questionnaires regarding family background and perceptions of medication treatment. Parents and teachers completed ratings of child diagnostic symptomatology, behavioral functioning, and functional impairment. Results indicate that only 45% of parents were open to the possibility of medication. No associations were found between child demographics, severity of ADHD symptoms, or level of functional impairment and parental openness to medication. On the other hand, children of parents who were open to medication tended to have higher levels of oppositionality and aggression (as reported by parents but not teachers) compared with children of parents who were not open to medication. These findings are discussed in the context of early intervention given their implications for a variety of treatment providers.
Unsupervised AMR-Dependency Parse Alignment

In this paper, we introduce an Abstract Meaning Representation (AMR) to Dependency Parse aligner. Alignment is a preliminary step for AMR parsing, and our aligner improves current AMR parser performance. Our aligner involves several different features, including named entity tags and semantic role labels, and uses Expectation-Maximization training. Results show that our aligner reaches an 87.1% F-Score score with the experimental data, and enhances AMR parsing.
Despite Increasing Size of Unrelated Donor (URD) Registries and the Global Cord Blood (CB) Inventory Racial Disparities in Access to URD and CB Grafts Persist: A Prospective 10 Year Analysis of 1,112 Patients

Abstract Background: Prompt access tosuitable hematopoietic stem cells is a prerequisite for effective allograft. Availability of HLA-matched URD C otherwise HLA-mismatched URDs or CB grafts (predominantly double-unit) are chosen. Acceptable CB grafts have a TNC dose > 1.5 x 107/kg/unit (> 2.5 x 107/kg for single unit grafts) & 4-6/6 donor-recipient HLA-match. Results: Of the 1,112 patients, 597 (54%) received 8/8 URD & 182 (16%) received a 7/8 URD transplant, 281 (25%) underwent CB transplant (278 with double-unit grafts) & 52 (5%) had no 7-8/8 URD or CB graft. The distribution of 1,112 8/8 URD, 7/8 URD, CB transplants & no 7-8/8 URD/ CB grafts by recipient ancestry is shown (Figure). The majority (66%) of Europeans received an 8/8 URD whereas the majority of non-Europeans (60%) received either a mismatched URD or CB graft. Southern Europeans were less likely to have an 8/8 URD than other Europeans (38% vs 71%, p To determine if donor access is improving, we then analyzed transplant type (or no URD/CB graft) by recipient ancestry in the last 4 years (recent period 5/2012-5/2016, n = 521) vs the earlier time period (10/2005-4/2012, n = 591) (Table). For this analysis, all non-southern Europeans were grouped. In recent years, disparity in graft access between ancestry groups persists. For example, in recent patients 40% of southern Europeans, 78% of other Europeans, 41% of non-African non-Europeans & only 19% of Africans received an 8/8 URD transplant (p Conclusion: Despite increasing URD registry/ CB inventory size, significant racial disparity persists in access to matched URDs. CB significantly extends transplant access especially to southern & non-European patients. In recent years, however, while 46% of African patients have received a CB graft, a significant number of these patients remain without a 7-8/8 URD or CB graft. Whilehaplo-identical donors offer an additional alternative graft source, the extension of minority patient transplant access using domestic CB units supports the importance of public CB bank funding especially for African patients and those without suitablehaplo-identical donors. Download : Download high-res image (76KB) Download : Download full-size image Download : Download high-res image (131KB) Download : Download full-size image Disclosures No relevant conflicts of interest to declare.
Cyclic Sieving and Cluster Duality of Grassmannian

We introduce a decorated configuration space $\mathscr{C}\!{\rm onf}_n^\times(a)$ with a potential function $\mathcal{W}$. We prove the cluster duality conjecture of Fock-Goncharov for Grassmannians, that is, the tropicalization of $\big(\mathscr{C}\!{\rm onf}_n^\times(a), \mathcal{W}\big)$ canonically parametrizes a linear basis of the homogeneous coordinate ring of the Grassmannian $\operatorname{Gr}_a(n)$ with respect to the Plucker embedding. We prove that $\big(\mathscr{C}\!{\rm onf}_n^\times(a), \mathcal{W}\big)$ is equivalent to the mirror Landau-Ginzburg model of the Grassmannian considered by Eguchi-Hori-Xiong, Marsh-Rietsch and Rietsch-Williams. As an application, we show a cyclic sieving phenomenon involving plane partitions under a sequence of piecewise-linear toggles.
David Oliver: Getting serious about prevention

It’s hard to attend any conference or read any report on health service reform without prevention of ill health featuring prominently. What might once have seemed a radical proposition is now an orthodoxy—but people commenting on health system redesign still advocate a greater focus on prevention and early intervention as if it’s a revelation, even for those in government. The arguments advanced for prevention contain two broad elements. Firstly, our health services are still too centred on responding to ill health, especially acute illness in excessively hospital based models. We therefore need a shift of resources and approaches to ensure that more people remain well for longer (primary prevention) or are supported to self manage any long term …
Rift Valley fever in animals and humans: Current perspectives.

Abstract Rift Valley fever (RVF) is an ecologically complex emerging arboviral disease that causes significant illness in both livestock and people. This review article is designed to assist the reader in understanding the varied aspects of RVF disease in animals and humans. The historical facets of RVF disease, including the evolution of human outbreaks, are presented and discussed. The different clinical presentations of human RVF disease and the underlying causes are then addressed. We explore the exposure and transmission potential of RVF in animals and people. In the concluding section, we discuss the historical role of RVF as a biological weapon. We conclude with an outline of the important unanswered questions for ongoing research into this important zoonotic disease.
AA attendance and abstinence for dually diagnosed patients: a meta‐analytic review

BACKGROUND AND AIMS There is consensus that best clinical practice for dual diagnosis (DD) is integrated mental health and substance use treatment augmented with Alcoholics Anonymous (AA) attendance. This is the first quantitative review of the direction and magnitude of the association between AA attendance and alcohol abstinence for DD patients. METHOD A systematic literature search (1993-2017) identified 22 studies yielding 24 effect sizes that met our inclusion criteria (8075 patients). Inverse-variance weighting of correlation coefficients (r) was used to aggregate sample-level findings and study aims were addressed using random- and mixed-effect models. Sensitivity and publication bias analyses were conducted to assess the likelihood of bias in the overall estimate of AA-related benefit. RESULTS AA exposure and abstinence for DD patients were associated significantly and positively [rw = 0.249; 95% confidence interval (CI) = 0.203-0.293; tau = 0.097). There was also significant heterogeneity in the distribution of effect sizes and high between-sample variance (I2 = 74.6, P < 0.001). Subgroup analyses indicated that the magnitude of AA-related benefit did not differ between 6- (k = 7) and 12- (k = 12) month follow-up (Q = 0.068, P = 0.794), type of treatment received (in-patient k = 9; intensive out-patient, out-patient, community k = 15; Q = 2.057, P = 0.152), and whether a majority of patients in a sample had (k = 11) or did not have (k = 13) major depression (Q = 0.563, P = 0.453). Sensitivity analyses indicated that the overall meta-analytical estimate of AA benefit was not impacted adversely or substantively by pooling randomized controlled trial (RCT) and observational samples (Q = 0.763, P = 0.382), pooling count, binary and ordinal-based AA (Q = 0.023, P = 0.879) and outcome data (Q = 1.906, P = 0.167) and reversing direction of correlations extracted from studies (Q = 0.006, P = 0.937). No support was found for publication bias. CONCLUSIONS Clinical referral of dual diagnosis patients to Alcoholics Anonymous is common and, in many cases, dual diagnosis patients who attend Alcoholics Anonymous will report higher rates of alcohol abstinence relative to dual diagnosis patients who do not attend Alcoholics Anonymous.
Preoperative Assessment of the High-Risk Elderly

The ability of patients to meet the stresses of surgery and anesthesia should be assessed in the preoperative period in order to quantitate the cardiovascular, respiratory, and metabolic functional deficits. The high-risk patient who must undergo surgery presents a judgment decision for the internist, surgeon, and patient. Unfortunately, preoperative risk assessment without optimization of the patient does little to diminish intraoperative and postoperative morbidity and mortality.
The Orbital Correction Method

It may be helpful at the outset to state briefly the method and the findings which we are to discuss. The orbital correction method is an approximate scheme for computing the total energy of molecules as a function of the arrangement of the constituent atoms. It is based upon a self-consistent-field treatment of the electron-electron interaction and an expansion technique analogous to perturbation theory. The expansion parameter in this case is the difference between the true one-electron state and an assumed starting state, which is essentially a linear combination of atomic orbitals. The simplification allowed by this expansion permits the treatment of arbitrarily large systems and gives a simple framework for the treatment of all properties of molecular systems. Preliminary application to the central hydrides illustrates the fact that many properties can be meaningfully treated in zero order (no orbital correction), while the inclusion of the orbital correction is absolutely essential in others.
A Parallel Quasi-Monte Carlo Method for Computing Extremal Eigenvalues

The convergence of Monte Carlo methods for numerical integration can often be improved by replacing pseudorandom numbers (PRNs) with more uniformly distributed numbers known as quasirandom numbers (QRNs). In this paper the convergence of a Monte Carlo method for evaluating the extremal eigenvalues of a given matrix is studied when quasirandom sequences are used. An error bound is established and numerical experiments with large sparse matrices are performed using three different QRN sequences: Sobol', Halton and Faure. The results indicate: • An improvement in both the magnitude of the error and in the convergence rate that can be achieved when using QRNs in place of PRNs. • The high parallel efficiency established for Monte Carlo methods is preserved for quasi-Monte Carlo methods in this case. The execution time for computing an extremal eigenvalue of a large, sparse matrix on p processors is bounded by O(lN/p), where l is the length of the Markov chain in the stochastic process and N is the number of chains, both of which are independent of the matrix size.
Agile and robust resource management in csma wireless networks

With the recent push towards wireless broadband, and user migration towards mobile devices, it has become imperative for wireless networks to support higher network capacity, increased battery life, and greater mobility. While a combination of both local- and wide-area wireless technologies will be needed to meet these requirements, we believe that carrier-sense multiple-access (CSMA) wireless networks, if designed well, can play an important role in the future. Traditional CSMA wireless networks, which form the basis for today's ubiquitous wireless LAN technology—IEEE 802.11 or WiFi, cannot satisfy the stated requirements mainly because they lack efficient resource management (or resource parameter adaptation) techniques. Several fundamental characteristics of these networks, and practical implementation challenges, also limit the applicability of solutions from other domains. Taken together, these considerations force us to fundamentally re-think the design of resource parameter adaptation for CSMA wireless networks. In this dissertation, we first identify that, to satisfy the requirements, resource management techniques for CSMA wireless networks should possess two fundamental, but conflicting properties, agility, and robustness. Briefly, to provide increased bandwidth to mobile users, agile solutions are required that exploit opportunities for improved performance; at the same time, solutions cannot afford to compromise on link robustness. In addition, we realize that striking this trade-off effectively calls for different solutions in indoor and outdoor environments. To prove these hypotheses, we present the design and implementation of two resource management frameworks, Symphony and Sonata, for indoor and outdoor environments respectively. Indoors, Symphony increases network capacity and battery life for mobile clients by addressing the classical problem of joint, per-link, transmit power control and rate adaptation. For improved robustness, Symphony uses novel mechanisms based on measuring the expected transmission time (ETT), and the utility of RTS/CTS frames, while relying on a learning approach to converge quickly to the right resource parameter choice. Outdoors, the Sonata framework introduces a novel and fundamental tradeoff between directionality and base station diversity for uplink transmissions. Using a new location-based approach for improved parameter convergence, Sonata is able strike the agility-robustness tradeoff effectively. Together, these frameworks prove that, achieving the right balance between agility and robustness can enable CSMA wireless networks to transition to the wireless broadband era.
Scriptotherapy: Eighteen Writing Exercises to Promote Insight and Wellness

Writing is a therapeutic tool which can be used for dealing with a variety of mental health issues such as anxiety, depression, ambivalence, and trauma. A number of counseling theories, like narrat...
Stereospecificity of Amino Acid Transport for Ehrlich Tumor Cells

The stereospecific nature of biological transport has long been recognized. In the past, DL mixtures of amino acids have often been used for transport studies, because of the limited availability of the individual isomers, and because the transport of t.he D isomers was assumed to be negligible. Both of these condit.ions have now been modified. n-Amino acids have been shown to have substantial affinities both for cellular uptake processes (l-3) and for intestinal absorption (4-8). In 1952, Christensen and Riggs (1) found that in the course of an hour or two each of the D isomers of six amino acids was accumulated by the Ehrlich tumor cell to nearly as great an extent as the L form. Scholefield found L-methionine only about 50% more effective than Dmethionine in inhibiting the uptake of glycine by the Ehrlich cell (2). In contrast to these observations, Paine and Heinz (3) found that the D isomers of several amino acids inhibited the uptake of 1.8 mM glycine only about 10% as strongly as did the L isomers. Two amino acids, histidine and phenylalanine, were tested both by Christensen and Riggs and by Paine and Heinz. The present experiments explain the discrepancy between the observations of Christensen and Riggs and those of Paine and Heinz, by showing that the initial uptake of the D isomer is indeed slow but that this slow uptake continues for many hours, eventually attaining distribution ratios not much lower than those reached more quickly by the L isomers. A similar behavior has also been shown for the isomers of tertiary leucine (ol-aminoP,P-dimethylbutyric acid) (9). This result requires, as discussed elsewhere (lo), that the differences in the rates of escape of t’he isomeric pairs must’ be even greater than the differences in their rates of entry. This report compares quantitatively the transport of n-alanine and n-valine into and from the Ehrlich cell with that of their L isomers. These two amino acids were selected to illust.rate each of two transport-mediating systems described for neutral amino acids (11, la), in order to assay independently the stereospecificity of these systems.
Enclosure Utilization and Enrichment Structure Preferences of Captive Coyotes

Environmental enrichment improves well-being of captive animals using a variety of tools, including adding complexity to the physical environment. Designing enrichment structures requires an understanding of behavioral and biological responses to enrichment efforts. Captive coyotes ( Canis latrans ) utilize shelter structures to hide, rest, and display vigilant behavior. Because these simple structures are regularly used, new and more complex enrichment structures could enhance enclosure enrichment. This study examined the time captive coyotes spent at discrete, complex enclosure features to determine: (1) how coyotes utilize enclosure space and shelter structures; and (2) if coyotes have a preferred enrichment structure design. Three enrichment structure designs (ramp, closed, and neutral) were installed simultaneously in 0.6-ha enclosures during two breeding seasons (January – March). Additional coyote pairs were monitored in control enclosures with simple structures. GPS-collars and scan sampling were used throughout a 28-day testing period to record space use and behavior. Coyotes spent most of their time at perimeter and open areas, but also exhibited a preference for shelter structures. Coyotes utilized the complex enrichment structures in treatment enclosures more than simple structures in control enclosures. Although there was no statistical preference for one specific type of complex structure, composite evidence from GPS-collars and behavioral data suggested that coyotes were most frequently located at ramp structures. Coyotes utilized ramp structures more during the daytime and demonstrated higher rates of vigilance there. This study advances the knowledge of captive coyote spatial patterns while helping improve environmental enrichment planning for captive facilities through the exploration of adding complexity to animal enclosures.
Introduction: Framing the Problem

In this opening chapter, we establish the background of Model-Based Systems Engineering (MBSE) in terms of the evolution of complex, high-technology systems and the challenges those systems present. This material is the essential foundation for the remainder of the book. We open the discussion by considering the aesthetic and technical dimensions of system architecting and provide the underlying rationale for MBSE. We then describe the historical context for our subject and start a process of defining terms that will continue in the following chapters. Because the subject of open architecture is so fundamental in contemporary systems engineering, we devote a discussion to its basic principles. Most importantly for the remainder of the book, we then define a taxonomy and accompanying set of terms that will allow us to place various system architectures in consistent categories , avoiding misunderstandings and allowing us to discover characteristics that are shared among systems of a given kind. We also introduce a set of fundamental tenets of good system architecture, which will be used throughout the book. Finally, we briefly consider how architecture can contribute to successful system developments and the roles it should play in a program plan. Chapter objective: the reader will be able to describe and plan the role of MBSE in a complex system development, including the importance of achieving the tenets of effective architecture.
Redox and volatility of Tc(CO) 3 + compounds in waste glass melting

Abstract The behavior of non-pertechnetate (Tc(I)) species was studied by preparing three portions of dried low-activity waste-glass simulated feed, combining it with either the [fac-Tc(CO)3(OH)]4 “tetramer,” the [fac-Tc(CO)3(OH)(H2O)2] “monohydroxo,” or the [fac-Tc(CO)3Cl3]2- “trichloro,” and then heating samples to 600, 800, and 1000 °C. For the feeds and the heat-treated samples, Tc concentrations were measured by liquid scintillation counting (LSC) after NaOH and HNO3 fusion, and the results were used to determine the Tc volatility. For unheated samples and samples heated to 600 °C, the speciation of Tc was measured by X-ray absorption near-edge structure (XANES) analysis, while partitioning of Tc in the glass-forming melt was determined by leaching the samples in water and measuring the Tc concentration of the leachate. The current results are discussed in connection with previously reported data for Tc(VII) and Tc(IV) species to rationalize the potential mechanism on how different speciation of Tc affect its retention in glass.
Marker genes as predictors of shared genomic function.

Although high-throughput marker gene studies provide valuable insight into the diversity and relative abundance of taxa in microbial communities, they do not provide direct measures of their functional capacity. Recently, scientists have shown a general desire to predict functional profiles of microbial communities based on phylogenetic identification inferred from marker genes, and recent tools have been developed to link the two. However, to date, no large-scale examination has quantified the correlation between the marker gene based taxonomic identity and protein coding gene conservation. Here we utilize 4872 representative prokaryotic genomes from NCBI to investigate the relationship between marker gene identity and shared protein coding gene content. Even at 99–100% marker gene identity, genomes share on average less than 75% of their protein coding gene content. This occurs regardless of the marker gene(s) used: V4 region of the 16S rRNA, complete 16S rRNA, or single copy orthologs through a multi-locus sequence analysis. An important aspect related to this observation is the intra-organism variation of 16S copies from a single genome. Although the majority of 16S copies were found to have high sequence similarity (> 99%), several genomes contained copies that were highly diverged (< 97% identity). This is the largest comparison between marker gene similarity and shared protein coding gene content to date. The study highlights the limitations of inferring a microbial community’s functions based on marker gene phylogeny. The data presented expands upon the results of previous studies that examined one or few bacterial species and supports the hypothesis that 16S rRNA and other marker genes cannot be directly used to fully predict the functional potential of a bacterial community.
The relationship of body mass index (BMI) to job performance, absenteeism and risk of eating disorder among hospital-based nurses.

Abstract Obesity has been linked to job absenteeism and decreased job performance. Additionally, shift work may be related to abnormal eating in nurses. This study examines the relationship between body mass index, job performance, absenteeism, and eating disorder risk among nurses. Registered Nurses (n = 63) participated in a survey that included the Work Limitations Questionnaire and the Eating Attitudes Test. Most participants were either overweight or obese. Significant correlations were noted between body mass index and job performance, and body mass index and risk of eating disorders. An understanding of how increased body mass index can affect a nurse's job performance and wellness warrants continued attention from the nursing profession.
Differences in proximal tubular solute clearance across common etiologies of chronic kidney disease.

Background Laboratory measures of glomerular function such as the glomerular filtration rate (GFR) contribute toward clinical evaluation of chronic kidney disease (CKD). However, diverse CKD etiologies have distinct pathological mechanisms that may differentially impact the kidney tubules. Little is known regarding how tubular function changes with varying kidney disease types. Methods We used targeted mass spectrometry to quantify paired serum and urine concentration of 11 solutes of proximal tubular secretion in 223 patients from an outpatient CKD cohort. We reviewed clinic notes to ascertain the primary CKD diagnosis and categorized these as vascular, diabetic, glomerular or tubulointerstitial. We used one-way analysis of variance to compare secretory solute clearance across diagnoses setting a false discovery threshold of ≤5% and used linear regression to compare differences after adjustments for estimated GFR, age, race, sex, body mass index and urine albumin excretion. Results After full adjustment, glomerular disease was associated with higher clearances of three tubular secretory solutes compared with vascular disease: 48% higher isovalerylglycine clearance [95% confidence interval (CI) 18-87%], 28% higher kynurenic acid clearance (95% CI 3-59%) and 33% higher tiglylglycine clearance (95% CI 7-67%). Diabetic kidney disease (DKD) was associated with 39% higher isovalerylglycine clearance compared with vascular disease (95% CI 13-72%). Conclusion Glomerular disorders and DKD are associated with higher net clearances of several secretory solutes compared with vascular causes of kidney disease. These findings suggest that different underlying etiologies of CKD may differentially impact proximal tubular secretory pathways.
Behavior of high strength concrete – filled hybrid large – small rupture strains FRP tubes

Abstract This paper experimentally investigates the behavior of concrete filled fiber reinforced polymer (FRP) tubes (CFFTs) under cyclic axial compression. The FRP used in this study was either small rupture strain FRP (SRS-FRP), large rupture strain FRP (LRS-FRP), or hybrid LRS-FRP and SRS-FRP. LRS-FRPs are manufactured out of polyethylene naphthalate (PEN) and polyethylene terephthalate (PET). LRS-FRP has a high tensile rupture strain (usually greater than 5%) compared to 1–2% for SRS-FRP. The behavior of the investigated cylinders is presented in terms of ductility, ultimate strain, strength improvement, and energy dissipation. The results showed that using LRS-FRP significantly improved the ductility and ultimate strength of the confined concrete compared to SRS-FRP confined concrete. This study also carried out a comparison between the attained strengths, as well as the ultimate axial strain and the existing analytical models. A critical assessment of recent models has been made to suggest two models be implemented for predicting the ultimate stress–strain behavior of hybrid LRS-FRP.
Case of COVID-19 presenting with gastrointestinal symptoms

Patients with coronavirus disease 2019 (COVID-19) predominantly present with the pulmonary symptoms such as fever, cough, and shortness of breath. We present a case of an 83 years old patient with COVID-19 who presented with only gastrointestinal symptoms without respiratory complaints. Our case raises the concern regarding our current lack of understanding of extrapulmonary manifestations of COVID-19. Given genetic homology between 2019 severe acute respiratory syndrome coronavirus (SARS-CoV) 2 and SARS-CoV, our case underscores the urgent need for further studies to understand the role of the gastrointestinal system in 2019 SARS-CoV-2 transmission and COVID-19 pathogenesis.
A Tale of Two DUSP27s - Proposed Resolution for the Naming of Distinct Dual-Specificity Phosphatases

There are currently two dual specificity phosphatases that are referred to in the literature as DUSP27, which has the potential to cause significant confusion as work on both genes is still very pr...
Brilliant and Benevolent: The Optimism of Teresa Amabile’s Legacy for Creativity in Organizations

This chapter drills down on a less known paper published by Teresa— “Brilliant but Cruel”—a paper that showed that those who gave negative reviews were perceived to be more intelligent than those who gave positive reviews. He proposes and provides initial evidence to support a fascinating idea: Rather than being critical, being optimistic and benevolent may actually contribute to more accurate evaluations of creative ideas.
A New Form of Business Entity Is Neededto Promote Social Entrepreneurship:The Not-for-Loss Corporation

Philanthropy frequented the headlines in 2006. The personal fortunes of high-profile individuals, such as Warren Buffet, Bill and Melinda Gates, and Richard Branson, became the engines of social change. 3 Social entrepreneurship gained serious commercial focus, with awards like the X Prize recognizing social and scientific achievement and corporations like Google dedicating resources to eradicating poverty, stopping climate change and eliminating world hunger. A trend points to a correlation between business and social change. As this trend continues, the distinction between for-profit and nonprofit blurs, evidencing a decaying, century-old dichotomy, which has become stale to its modern participants. A new corporate structure is needed to bridge the gap— reflecting the power for social change possessed in the traditional for-profit corporation and breathing sustainability into the 501(c)(3) nonprofit. Standing on opposite sides of this divide are the members of each camp, searching for middle
Monetary Policy in Central and Eastern Europe : Lessons After Half a Decade of Transition

The paper uses data from transition economies in Central and Eastern Europe to assess four questions: (i) Did the standard blueprint for stabilization work, and was it implemented? (ii) To what extent was normal macroeconomics impeded by solvency problems in banks, and how successful have been policies to improve incentives within banks? (iii) Could financial markets and other infrastructure for monetary policy have been developed more quickly? (iv) How should transition economies respond to the monetary inflows that typically accompany success? The paper concludes by evaluating the changing advice offered by external agencies during the 1990s.
Intraoperative Ketorolac is Associated with Risk of Reoperation After Mastectomy: A Single-Center Examination.

Although ketorolac is an effective adjunct for managing pain in the perioperative period, it is associated with a risk of postoperative bleeding. This study retrospectively investigated the association between ketorolac use and both reoperation and postoperative opioid use among mastectomy patients. The study identified all women undergoing mastectomy (unilaterally or bilaterally) at our ambulatory surgery cancer center from January 2016 to June 2019. The primary outcome was reoperation for bleeding on postoperative day 0 or 1, and the secondary outcome was postoperative opioid use. The association between ketorolac and outcomes was assessed using multivariable regression models. The covariates were age, body mass index, breast reconstruction, bilateral surgery, peripheral nerve block, and preoperative antiplatelet and/or anticoagulation medication. A cohort of 3469 women were identified. Ketorolac was given to 1549 (45%) of the women, with 922 women (60%) receiving 30 mg and 627 women (40%) receiving 15 mg. The overall reoperation rate for bleeding was 3.1% (1.8% without ketorolac vs 4.8% with ketorolac). In the multivariable analysis, ketorolac was associated with a higher risk of reoperation [odds ratio (OR) 2.43; 95% confidence interval (CI) 1.60–3.70; P < 0.0001]. Ketorolac also was associated with a lower proportion of patients receiving any postoperative narcotic within 24 h (15 mg: OR 0.73; 95% CI 0.57–0.94; P = 0.014 vs 30 mg: OR 0.52; 95% CI 0.42–0.66; P < 0.0001). Ketorolac use decreased postoperative opioid use, but this benefit was outweighed by the increased risk of bleeding requiring reoperation. This finding led to a change in practice at the authors’ center, with ketorolac no longer administered in the perioperative care of the mastectomy patient.
An Embedded Librarian’s Experience Piloting a Subject-Specific OER Initiative

This case study will describe the labor and collaborative efforts to-date made by an embedded librarian to pilot an OER textbook creation and/or adoption program in her liaison area—a school of education serving approximately 850 graduate and 150 undergraduates at a private Catholic university on the West Coast. This case study will explore the initial project goals, successes (e.g., administrative support and graduate student enthusiasm), and challenges (e.g., faculty buy-in, unbalanced labor, OER creation support) encountered in this project. The study will also discuss the librarian’s professional development undertakings in effort to fill OER creation and platform knowledge gaps. Finally, the study will discuss the librarian’s next steps for this project in the upcoming academic year.
Effects of Overweight and Obesity on Running Mechanics in Children.

Purpose The purpose of this study is to determine differences in running mechanics between healthy weight (HW) children and children classified as OW/OB. Methods Forty-two children (17 OW/OB, 25 HW) ran overground while kinematic and kinetic data were recorded using a motion capture system and force plate. Kinematic variables of interest included stance time, step length, and frontal and sagittal plane joint angles and excursions at the hip, knee, and ankle. Kinetic variables of interest included ground reaction forces and hip, knee, and ankle moments in the sagittal and frontal planes. Results The OW/OB group spent more time in stance, took shorter steps, displayed less hip flexion during the first half of stance, had greater ankle inversion at foot strike, had greater knee abduction throughout stance, and had smaller knee flexion, knee adduction, and hip adduction excursions. In comparing unscaled ground reaction forces, the OW/OB group displayed greater peak vertical force, vertical impact peaks, and vertical loading rates. The OW/OB group also displayed greater unscaled plantar and dorsiflexion moments, knee flexion and extension moments, ankle inversion moments, and knee and hip abduction moments. Conclusion These data suggest that increased body weight in children is associated with changes in running mechanics. Higher joint moments and ground reaction forces may indicate increased injury risk or the development of joint degeneration among overweight/obese children.
iLabs as an online laboratory platform: A case study at Stanford University during the COVID-19 Pandemic

The iLabs platform – a low cost, highly scalable way to provide online learning for remote and virtual laboratory experiments is introduced into a classroom setting for the first time. As the COVID-19 pandemic has disrupted conventional laboratory experiment-based teaching, the iLabs platform can be a potential solution to include remote and virtual experiments in the curricula. As a case study, the process and challenges of integrating an iLabs experiment into a course are discussed. The described process includes converting a physical experiment into an iLabs experiment and using it as a teaching tool in one course at Stanford University during the Autumn 2020-2021 quarter. Feedback collected from the students is discussed. Although performed on a small scale, the case study suggests that the platform has the potential to be a helpful teaching tool for science and technology classes. In addition to being a substitute for a physical laboratory during the pandemic, the platform can be included as a supplementary teaching tool complementing physical laboratory experiments after the pandemic as well and will aid remote education.
Peritransplant Ruxolitinib Administration is Safe and Effective in Patients with Myelofibrosis: a Pilot Open-Label Study.

We report results of our prospective pilot trial (NCT02917096) evaluating safety/feasibility of peri-transplant administration of ruxolitinib for myelofibrosis treatment. Primary objectives were to determine the safety and identify maximum tolerated dose (MTD) of ruxolitinib. Ruxolitinib was given at two dose levels (DL) of 5 and 10mg twice daily, with fludarabine/melphalan conditioning regimen and tacrolimus/sirolimus GVHD prophylaxis. We enrolled 6 and 12 patients in DL-1 and DL-2, respectively. Median age at transplant was 65 years (range:25-73) for all patients. Per DIPSS, 4 patients were at high and 14 were at intermediate risk. PBSCs was the graft source from a matched sibling (n=5) or unrelated (n=13) donor. At each DL one patient developed DLTs: Grade 3 cardiac and GI with Grade 4 pulmonary in DL-1 and Grade 3 kidney injury in DL-2. All patients achieved engraftment. Cumulative incidence (CI) of acute GVHD grade 2-4 and 3-4 were 17% (95% CI: 6-47) and 11% (95% CI: 3-41), respectively. CI of 1-year chronic GVHD was 42% (95% CI: 24-74). With the median follow-up of 22.6 months (range:6.2-25.8) in surviving patients the 1-year overall and progression free survival were 77% (95% CI: 50-91) and 71% (95% CI: 44-87), respectively. Causes of death (n=4) were cardiac arrest, GVHD, respiratory failure, and refractory GVHD of liver. Our results showed that peri-HCT ruxolitinib was safe and well-tolerated with the MTD determined as 10 mg BID, associated with dose-dependent PK and cytokine profile. The early efficacy data are highly promising in this group of high-risk older patients with MF.
Mass spectrometry for human kinome analysis

Abstract Kinases are involved in numerous critical cell signaling processes, and dysregulation in kinase signaling is implicated in many human diseases. Therefore, comprehensive analysis of protein expression and activation of kinases at the entire proteome scale is important for developing drugs for the treatment of human diseases. Over the past few decades, mass spectrometry has evolved into a powerful and indispensable bioanalytical tool for the facile identification and quantification of proteins. Mass spectrometry-based proteomic methods are now widely employed in human kinome analysis, and these methods offer quantitative information about the expression levels and ATP-binding affinities of more than 300 kinases. In this chapter, we review the applications of various mass spectrometry-based proteomic methods, including label-free and metabolic/chemical labeling approaches, for interrogating quantitatively the human kinome. We also survey the utilizations of different types of data acquisition methods, including data-dependent and data-independent acquisition (DDA and DIA), as well as targeted proteomic approaches, relying on multiple- and parallel-reaction monitoring (MRM and PRM), for the comprehensive assessment of the human kinome.
The influence of dietary fats on hypercoagulation and thrombosis.

A distinct impression is emerging from the literature that nutrition plays an important role in haemostasis and thrombosis. Although present knowledge is sketchy and newer information is still needed to place nutritional-thrombotic interrelationships on a firm foundation, recent literature shows that dietary fats alter platelet function and that this might occur as a consequence of alterations of platelet lipids. Thus far, feeding studies in man and animals have shown alterations in platelet factor 3 (PF-3), platelet aggregation, and platelet lipids.
Translation and Criticism

At a conference in Paris, in March, 1967, I heard Polish and French poets and translators discuss the problems of translation. Their immediate theme was three anthologies of recent Polish poetry translated into English, French, and German respectively. But they went, of course, quickly and far out beyond the topic at hand. To their efforts at discussing the problems of translation was added a strik ing piquancy: that much of the conference's discussion of translation was car ried on by means of translation. That situation made the whole event more meaningful than I could quite analyze. The discussers were thereby put into an unusual position. Some of their analyses were communicated to one another in a medium or form which was an example of the thing they were discussing. The conditions of their act of communication were the most eloquent comment to be made on the contents of their communication. Not only the difficulty of translation was illustrated, by that situation; but also the fact that even in talking about translation we go out be yond our analyses, and forget how difficult it is for us even to discuss the diffi culty of understanding one another across language barriers. It is in various ways worth thinking about what kinds of alleviation trans lation can be, to the burden of language barriers. We often think it can provide equivalents, in a new language, for what was written in another language. This concept of equivalents or equivalence needs a close look, for it opens the door to a flock of confusions. I have fought with the idea already, but it is well worth returning to here. 'Equivalence' usually means, in the kind of case I am thinking of, 'value in a new language which is like and worth the value of that from which the trans lation was made, the original.' I have already examined some of the roots?onto logical and political?of this conviction: here I simply state it. Sometimes this conviction joins with the belief that translations can deal very freely with their originals, and sometimes with the opposite belief, that translations must be very, as it is called, 'literal.' Either of these views, and a spectrum of possibilities lying between them, can be supported by the kind of equivalence-conviction I describe. These opposed views have in common, in the present case, the conviction that they represent ways of establishing equivalence. There is an alternative to this definition, or at least another way of looking at it; a view of translation which if not original is at least unorthodox, which is backed up by many contexts, and which has the merit of describing translation's relation to the main landmass of meaningful uses of language.
IDC waterproof connector for flat wiring harness

There is a trend toward integration of several components in automobiles into modules and we have developed a new wiring system suitable for module components. This new wiring harness consists of multi core flat cable that has zero-halogen insulation. The features are weight reduction and simplification of the manufacturing process. The connector for this system is IDC (Insulation Displacement Contact) and hotmelt overmold is used for waterproofing the IDC. The mechanics of the waterproofing is adhesion between surfaces of cable insulation, connector housing and hotmelt. We have developed a new hotmelt material that can adhere to both nonpolar compounds (zero-halogen cable insulation) and polar compounds (connector housing), and is a highly reliable waterproof IDC connector that can be used in engine compartments. We also discuss a compact facility that can simultaneously operate both IDC and a hotmelt molding process.
Abstract P131: Association between Marijuana Exposure and Cognitive Function in Middle Age: the Coronary Artery Risk Development in Young Adults (CARDIA) study.

Background: Smoking marijuana is increasingly common, and understanding whether it is associated with long-term cognitive dysfunction has important implications for public health messaging. Aims: We estimated associations between cumulative exposure to marijuana and cognitive function (CF), adjusted for current marijuana use, cigarette smoking and other determinants of CF. Methods: Participants in the CARDIA Study, a population-based study of African Americans and European Americans recruited in 1985/6 at age 18-30 and followed over 25 years. Marijuana use was assessed at clinical visits at years 0, 2, 5, 7, 10, 15, 20 and 25 (2010/11); and cigarette smoking each year. Lifetime exposure to marijuana was expressed in joint-years, with 1 joint-year equivalent to smoking 365 joints. CF at year 25 was assessed with the Rey Auditory Verbal Learning Test (RAVLT), the Digit Symbol Substitution Test (DSST) and the Stroop Interference Test, each expressed as standardized z-scores. We estimated associations between...