cssi/SciSciGPT-SciSciNet huggingface dataset:
Time-course and risk factors of hypothyroidism following allogeneic hematopoietic stem cell transplantation (HSCT) in children conditioned with fractionated total body irradiation.

Background Hypothyroidism is a complication of hematopoietic stem cell transplantation (HSCT)1 that has been studied primarily in children after matched sibling bone marrow transplantation. Unrelated donors and umbilical cord blood (CB) are now used in transplantation, and hypothyroidism in these populations is undocumented. Children who underwent fractionated total body irradiation (fTBI) and received bone marrow or umbilical cord blood transplantation from siblings or unrelated donors were examined for hypothyroidism over time. Procedure All children who received fTBI prior to allogeneic HSCT at The Children's Hospital (TCH), Denver between 1994 and 2002, and survived >1 year were included (N = 41 eligible; N = 33 met inclusion criteria). Probability of hypothyroidism was estimated by the Kaplan–Meier method and groups were compared using Cox's proportional hazards regression model. Results Hypothyroidism developed in 52% of the children at a median time of 1.9 years (range 0.7–8.3 years). Primary compensated hypothyroidism was diagnosed in 94% of those affected. Children who received unrelated donor HSCT were 8.4 times more likely to develop hypothyroidism than those receiving matched sibling HSCT. Recipients of CB were 4.6 times more likely to have hypothyroidism than recipients of bone marrow. Conclusions There is a significant risk of developing hypothyroidism following fTBI, and allogeneic HSCT, that appears greater in recipients of unrelated donor HSCT and CB transplantation. Most of our patients who received BMT had sibling donors and the majority of CB transplants were from unrelated donors. It is difficult to determine which association is related to hypothyroidism, but the combination is significant. Pediatr Blood Cancer 2008;51:405–409. © 2008 Wiley-Liss, Inc.
Comparison of Neuropathologic Criteria for the Diagnosis of Alzheimer’s Disease

The National Institute on Aging and Reagan Institute (NIA-RI) criteria, and other neuropathologic criteria for Alzheimer's disease (AD), were compared with the clinical diagnosis of dementia in a well defined population of Catholic sisters. The 47-participant subset examined in this study were college educated and lacked complicating conditions such as brain infarcts or diffuse Lewy body disease. Sixteen participants had a clinical diagnosis of dementia. The NIA-RI criteria imply a perfect correlation between neuritic plaque (NP) density and neurofibrillary tangle distribution. However, NP density often did not coincide with tangle distribution. As a result, it was not possible to categorize many of the participants using the NIA-RI guidelines. The 'high likelihood' category of the NIA-RI criteria for AD research settings (neocortical Braak stage and frequent neocortical NP) had relatively high specificity (90% of nondemented participants did not meet this criteria). However, only half of the demented participants were in this category. Neuropathologic criteria requiring the presence of neocortical tangles (rather than neocortical Braak stage) had relatively high sensitivity, accounting for 87-94% of participants with dementia, but also included 32-35% of nondemented participants. Criteria based on neocortical NP or senile plaques had 100% sensitivity, but a majority of nondemented participants also met these criteria. The results support consideration of both tangles and NP for the neuropathologic diagnosis of AD, but indicate that refinement of the NIA-RI criteria is necessary. A possible refinement is suggested for further consideration.
Nanoscale contact electrodes for significant radiation power enhancement in photoconductive terahertz emitters

We present a photoconductive terahertz emitter that incorporates nanoscale plasmonic contact electrodes to offer significantly higher radiation powers compared to conventional photoconductive terahertz emitters. Radiation enhancement is the result of reducing the average transport path of photogenerated carriers to the plasmonic contact electrodes and, thus, increasing the number of the photocarriers that can be routed to the terahertz antenna in a sub-picosecond time-scale to efficiently contribute to terahertz radiation. We experimentally demonstrate up to 50 times higher terahertz radiation powers from the presented plasmonic photoconductive terahertz emitter compared to a similar conventional photoconductive terahertz emitter without plasmonic contact electrodes.
Subnucleosomal Structures and Nucleosome Asymmetry across a Genome

Genes are packaged into nucleosomal arrays, each nucleosome typically having two copies of histones H2A, H2B, H3, and H4. Histones have distinct posttranslational modifications, variant isoforms, and dynamics. Whether each histone copy within a nucleosome has distinct properties, particularly in relation to the direction of transcription, is unknown. Here we use chromatin immunoprecipitation-exonuclease (ChIP-exo) to resolve the organization of individual histones on a genomic scale. We detect widespread subnucleosomal structures in dynamic chromatin, including what appear to be half-nucleosomes consisting of one copy of each histone. We also detect interactions of H3 tails with linker DNA between nucleosomes, which may be negatively regulated by methylation of H3K36. Histone variant H2A.Z is enriched on the promoter-distal half of the +1 nucleosome, whereas H2BK123 ubiquitylation and H3K9 acetylation are enriched on the promoter-proximal half in a transcription-linked manner. Subnucleosome asymmetries might serve as molecular beacons that guide transcription.
Plant Growth Stage-Specific Injury and Economic Injury Level for Verde Plant Bug, Creontiades signatus (Hemiptera: Miridae), on Cotton: Effect of Bloom Period of Infestation

Verde plant bugs, Creontiades signatus Distant (Hemiptera: Miridae), were released onto caged cotton, Cossypium hirsutum L., for a 1-wk period to characterize the effects of insect density and bloom period of infestation on cotton injury and yield in 2011 and 2012, Corpus Christi, TX. When plants were infested during early bloom (10-11 nodes above first white flower), a linear decline in fruit retention and boll load and a linear increase in boll injury were detected as verde plant bug infestation levels increased from an average of 0.5 to 4 bugs per plant. Lint and seed yield per plant showed a corresponding decline. Fruit retention, boll load, and yield were not affected on plants infested 1 wk later at peak bloom (8-9 nodes above first white flower), even though boll injury increased as infestation levels increased. Second-year testing verified boll injury but not yield loss, when infestations occurred at peak bloom. Incidence of cotton boll rot, known to be associated with verde plant bug feeding, was low to modest (< 1% [2012] to 12% [2011] of bolls with disease symptoms), and drought stress persisted throughout the study. Caging effect was minimal: a 10% fruit retention decline was associated with caging, and the effect was not detectable in the other measurements. Overall, reduced fruit retention and boll load caused by verde plant bug were important contributors to yield decline, damage potential was greatest during the early bloom period of infestation, and a simple linear response best described the yield response-insect density relationship at early bloom. Confirmation that cotton after peak bloom was less prone to verde plant bug injury and an early bloom-specific economic injury level were key findings that can improve integrated pest management decision-making for dryland cotton, at least under low-rainfall growing conditions.
Inhibition of endogenous TRP1 decreases capacitative Ca2+ entry and attenuates pulmonary artery smooth muscle cell proliferation.

Pulmonary vascular medial hypertrophy due to proliferation of pulmonary artery smooth muscle cells (PASMC) greatly contributes to the increased pulmonary vascular resistance in pulmonary hypertensi...
‘Emergency!’ Or How to Learn to Live with Neoliberal Globalization

The author explores the cultural politics of neoliberal globalization, its deformations of critical facets of public culture as it has returned home, and he explores the politics of emergency. Rather than seeing the politics of emergency as something indicative of an emerging ‘emergency regime’ attendant to the terror war, he argues that the current politics of emergency is rooted in neoliberal globalization more generally, especially in terms of the need for powerbrokers to institutionalize insecurity and anxiety as central facets of a ‘new normal.’ He then turns to the criminalization and militarization of schools as examples of how the process of institutionalizing insecurity has unfolded in the last decade, suggesting that public schools are an ostensible and crucial site (being the one of the last sites to be precaritized) because the types of subjects and agents required for neoliberal globalization must learn how to live (in fear) with neoliberal globalization. Without an understanding of how schoo...
The Effect of Teacher Role Development Training on Undergraduate Music Education Majors: A Preliminary Study

The purpose of this study was to examine effects of teacher role development training on undergraduate music education majors’ teaching effectiveness, attributions for success and failure in music teaching, and confidence to continue pursuing a music teaching career. Participants (N = 18) included students who had received teacher role development training (n = 9) and students who had not received such training (n = 9). Participants completed the Concerns, Attributions, and Confidence Measure. Participants’ teaching effectiveness was determined using the Survey of Teaching Effectiveness. No significant differences were found between the two groups for any dependent variables; however, main effect differences were found among levels of concerns and among areas of attribution for success or failure in teaching.
Opinion filtered recommendation trust model in peer-to-peer networks

A multiagent distributed system consists of a network of heterogeneous peers of different trust evaluation standards. A major concern is how to form a requester's own trust opinion of an unknown party from multiple recommendations, and how to detect deceptions since recommenders may exaggerate their ratings. This paper presents a novel application of neural networks in deriving personalized trust opinion from heterogeneous recommendations. The experimental results showed that a three-layered neural network converges at an average of 12528 iterations and 93.75% of the estimation errors are less than 5%. More important, the model is adaptive to trust behavior changes and has robust performance when there is high estimation accuracy requirement or when there are deceptive recommendations.
An Investigation of the Relationship between Color Choice and Depression Measured by the Beck Depression Inventory

The relationship between self-reported depression and color preference was investigated. It was proposed that a cognitive schema would be activated affecting negatively that part of the environment selected for cognitive preference. When requested to select a series of preferred colors, the 72 undergraduates scoring above 10 on the Beck Depression Inventory tended to choose black or brown. It is believed that internal schema represented in 3 questions may be reflected in color choice(s).
THE LEGACIES OF WRITING CULTURE AND THE NEAR FUTURE OF THE ETHNOGRAPHIC FORM: A Sketch

This article argues that the most lively contemporary legacy of the 1980s Writing Culture critiques now lie outside, or beyond, conventional texts but, rather, in the forms that are integral to fieldwork itself. Fieldwork today requires a kind of collaborative concept work that stimulates studios, archiving, para-sites, which in turn constitute the most innovative expressions of ethnography, difficult to capture in the traditional genre.
Electrokinetic transport in a water–chloride nanofilm in contact with a silica surface with discontinuous charged patches

This paper reports on simulations of electrokinetic transport in an electrolyte nanofilm in contact with a negatively charged substrate with discontinuous counter-charged patches. All-atom molecular dynamics simulations of an aqueous solution of chloride placed on a silica slab were conducted. The response of the system is investigated as it is subjected to different axial electric fields and as the surface electrostatics is modified by implementing different positive charge densities on the patches. Chloride and water density profiles reveal that the charged patches cause an enrichment of hydrated chloride ions near the surface. Therefore, the system with patches proved to be successful in trapping ions. Moreover, the number of chloride ions trapped on the surface increases as higher charge densities are imposed on the patches. It is observed that higher axial electric fields remove chloride ions from the surface; however, the amount removed decreases as higher charge densities are imposed on the patches. Velocity profiles show a stagnant water layer near the patches. The water and ion accumulation suggest the formation of a Stern layer with thickness of ca. 0.4 nm on the patches. Higher chloride density near the surface and increased surface-water affinity induced by the presence of charged patches result in smaller electroosmotic velocities. The simulation results compare well with velocities calculated using a continuum approach. This study shows that in a charged electrolyte solution in contact with a substrate, axial and normal ion distributions and consequently electroosmotic velocities can be controlled by modifying the electrostatics of the substrate.
High Energy Predictions from Perturbative Q.C.D.

It has recently become clear that there are many predictions which follow firmly from Q.C.D.1 This comes about because inclusive processes factor, in some cases, into a term which depends only on the light cone structure of Q.C.D. and a term which depends on the details of on-mass-shell hadrons. Because of asymptotic freedom the term which depends only on the light cone structure is calculable from a Cal1an-Symanzik equation.
HaloTag Technology for Specific and Covalent Labeling of Fusion Proteins

Appending proteins of interest to fluorescent protein tags such as GFP has revolutionized how proteins are studied in the cellular environment. Over the last few decades many varieties of fluorescent proteins have been generated, each bringing new capability to research. However, taking full advantage of standard fluorescent proteins with advanced and differential features requires significant effort on the part of the researcher. This approach necessitates that many genetic fusions be generated and confirmed to function properly in cells with the same protein of interest. To lessen this burden, a newer category of protein fusion tags termed "self-labeling protein tags" has been developed. This approach utilizes a single protein tag, the function of which can be altered by attaching various chemical moieties (fluorescent labels, affinity handles, etc.). In this way a single genetically encoded protein fusion can easily be given functional diversity and adaptability as supplied by synthetic chemistry. Here we present protein labeling methods using HaloTag technology; comprised of HaloTag protein and the collection of small molecules designed to bind it specifically and provide it with varied functionalities. For imaging purposes these small molecules, termed HaloTag ligands, contain distinct fluorophores. Due to covalent and rapid binding between HaloTag protein and its ligands, labeling is permanent and efficient. Many of these ligands have been optimized for permeability across cellular membranes allowing for live cell labeling and imaging analysis. Nonpermeable ligands have also been developed for specific labeling of surface proteins. Overall, HaloTag is a versatile technology that empowers the end user to label a protein of interest with the choice of different fluorophores while alleviating the need for generation of multiple genetic fusions.
Modeling uncertainty in three-dimensional heat transfer problems

We present a generalized polynomial chaos method to solve the steady and unsteady heat transfer problems with uncertainty in boundary conditions, diffusivity coefficient and forcing terms. The stochastic inputs and outputs are represented spectrally by employing the orthogonal polynomial functionals from the Askey scheme, as a generalization of the original polynomial chaos idea of Wiener [1]. A Galerkin projection in random space is applied to derive the equations in weak form, and a parallel spectral/hp element method is employed to solve the resulting set of deterministic equations. Simulations in three-dimensional domains with stochastic dimension 38 and about 150 million unknowns are presented here for the first time.
“Et in Arcadia Ego” in John Fowles’s A Maggot: Postmodern Utopia

Early in John Fowles’s A Maggot (1985), a novel set in the eighteenth century, a character asks another what a person should do if that person had “pierced the secrets of the world to come” and found out that “this corrupt and cruel world should one day live in eternal peace and plenty”; should the prophet reveal his secret of future utopia? Alternately, suppose the seer knew that “the predestinate future of this world is full of fire and plague, of civil commotion, of endless calamity” (pp. 19–20); should the possessor of this knowledge tell other people of the discovery? The speaker thus evokes utopian peace and plenty while juxtaposing them to the idea of death; this prelude to an enigmatic novel suggests the “Et in Arcadia Ego” motif in art.
Parsimonious shooting heuristic for trajectory design of connected automated traffic part I: Theoretical analysis with generalized time geography

Abstract This paper studies a problem of designing trajectories of a platoon of vehicles on a highway segment with advanced connected and automated vehicle technologies. This problem is very complex because each vehicle trajectory is essentially an infinite-dimensional object and neighboring trajectories have complex interactions (e.g., car-following behavior). A parsimonious shooting heuristic algorithm is proposed to construct vehicle trajectories on a signalized highway segment that comply with boundary conditions for vehicle arrivals, vehicle mechanical limits, traffic lights and vehicle following safety. This algorithm breaks each vehicle trajectory into a few sections that are analytically solvable. This decomposes the originally hard trajectory design problem to a simple constructive heuristic. Then we slightly adapt this shooting heuristic algorithm to efficiently solve a leading vehicle problem on an uninterrupted freeway. To study theoretical properties of the proposed algorithms, the time geography theory is generalized by considering finite accelerations. With this generalized theory, it is found that under mild conditions, these algorithms can always obtain a feasible solution to the original complex trajectory design problem. Further, we discover that the shooting heuristic solution is a generalization of the solution to the classic kinematic wave theory by incorporating finite accelerations. We identify the theoretical bounds to the difference between the shooting heuristic solution and the kinematic wave solution. Numerical experiments are conducted to verify the theoretical results and to draw additional managerial insights into the potential of trajectory design in improving traffic performance. In summary, this paper provides a methodological and theoretical foundation for advanced traffic control by optimizing the trajectories of connected and automated vehicles. Building upon this foundation, an optimization framework will be presented in a following paper as Part II of this study.
Topology Optimization of Thermal Structures with Stress Constraints

It is known in topology optimization, that in the presence of thermal loading, the conventional maximum stiffness design objectives generally do not lead to maximum strength structures due to the design dependency of thermoelastic loads. In this paper we present the application of stress constraints to structural topology optimization problems with thermal loading in an effort to develop a new technique for the design of hot structures where thermal stresses are of primary concern. A modern stress-relaxation technique is employed to circumvent the singularity phenomena in the stress constraints. In addition, we utilize stress aggregation functions to reduce the number of constraints in the optimization problem. We note that pre-existing formulations for thermoelastic topology optimization and stress-constraint handling are employed, but for the first time they are combined to consider thermal stresses. Preliminary numerical results indicate that the stress-constrained problem leads to different designs with superior thermoelastic performance when compared to the minimum compliance problems. In today’s aerospace industry, a number of practical examples are evident where the capability developed in this work is desirable. These include the design of engine exhaust-washed structures (EEWS) on embedded engine aircraft and integrated thermal protection systems (TPS) on hypersonic vehicles. In both cases, structural components are subjected to an extreme combined loading environment that is characterized by elevated temperatures and design against thermal stresses is of paramount concern.
A Harmonic X-Ray FEL Oscillator

A hard X-ray free electron laser oscillator operating at 5th harmonic frequency driven by a 4 GeV superconducting linac is compared with high-gain amplifiers producing self-amplified-spontaneous-emission in photon performance and the facility scale.
Prediction of flow and acoustic fields of a supersonic jet

Jet noise suppression has become a critical issue for the development of high speed civil transport plane. The successful development of such plane is contingent upon reducing its jet exhaust noise. The present paper reviews efforts directed at first principle computation of jet flow and noise. Representative work is summarized and discussed.
A PHYLOGENETIC RECONSTRUCTION OF THE MEXICAN CYPRINID FISH GENUS ALGANSEA

Jensen, R. J.,' and C. D. Barbour. (Department of Biological Sciences, Wright State University, Dayton, Ohio 45435) 1981. A phylogenetic reconstruction of the Mexican cyprinid fish genus Algansea, Syst. Zool., 30:41-57.-Phenetic and cladistic methods have been employed to estimate evolutionary relationships in Algansea, a small genus of Mexican cyprinid fishes. Cluster analyses and ordinations were prepared from various association, correlation, and distance matrices. Cladistic analyses were prepared in the form of a Wagner analysis (after Farris), compatibility analysis (after Estabrook), and a non-numerical phylogeny (after Hennig). All analyses utilized the same set of morphological and ecological characters to allow direct comparisons of estimates of relationships. Cluster analyses produced different views of the relationships between taxa. Ordinations produced generally similar arrays of OTU's in total character space which, of the phenetic methods, were closest to the identical solutions given by Wagner and compatibility analyses. A minimum spanning tree derived from taxonomic distances resulted in a network that also reflected the same relationships indicated by the cladistic methods. A reinvestigation of the relationships among the barbelled species of Algansea based in part on the distribution of shared apomorphies not included in the larger analysis confirmed the existence of a polyphyletic species. Possible solutions to this problem are discussed. [Algansea; Mexico; cladistics; ordination; cluster analysis; polyphyly.] The advent and rapid spread of numerical taxonomy has resulted in a reassessment of taxonomic methodology and philosophy. In an effort to turn the largely intuitive classical systematics into a method of analysis characterized by objectivity and repeatability, pioneering numerical taxonomists separated evolutionary speculation from taxonomic procedure. Their approach was intended to be a strictly phenetic operation utilizing a large number of unweighted characters, and serving as an efficient means of recognition, identification and classification of taxa. The results, which may be expressed as phenograms, were not meant specifically to reflect historical relationships (Sneath and Sokal, 1973). The reluctance of taxonomists to dismiss phylogenetic thinking has been well documented in the pages of this and other journals. Some authors have concluded that the phenetic approach can
RANKL-based osteoclastogenic assays from murine bone marrow cells

The osteoclast is the unique type of cell that resorbs bone in vivo and it is required for normal skeletal development and postnatal homeostasis. Osteoclast deficiency impairs skeletal development during embryogenesis and results in osteopetrosis and impaired tooth eruption. In contrast, excessive osteoclast formation in adults results in bone loss in a number of conditions, including osteoporosis, rheumatoid arthritis, and metastatic bone disease. Osteoclasts are derived from monocytes/macrophages; they can be generated in vitro by treatment of these precursor cells with macrophage colony stimulating factor (M-CSF) and receptor activator of NF-κB ligand (RANKL). This chapter describes procedures for generating osteoclasts from mouse bone marrow cells in vitro using M-CSF and RANKL and assessing their ability to form resorption lacunae on thin bone slices.
Geographic distribution of disaster-specific emergency department use after Hurricane Sandy in New York City

OBJECTIVE: We aimed to characterize the geographic distribution of post-Hurricane Sandy emergency department use in administrative flood evacuation zones of New York City. METHODS: Using emergency claims data, we identified significant deviations in emergency department use after Hurricane Sandy. Using time-series analysis, we analyzed the frequency of visits for specific conditions and comorbidities to identify medically vulnerable populations who developed acute postdisaster medical needs. RESULTS: We found statistically significant decreases in overall post-Sandy emergency department use in New York City but increased utilization in the most vulnerable evacuation zone. In addition to dialysis- and ventilator-dependent patients, we identified that patients who were elderly or homeless or who had diabetes, dementia, cardiac conditions, limitations in mobility, or drug dependence were more likely to visit emergency departments after Hurricane Sandy. Furthermore, patients were more likely to develop drug-resistant infections, require isolation, and present for hypothermia, environmental exposures, or administrative reasons. CONCLUSIONS: Our study identified high-risk populations who developed acute medical and social needs in specific geographic areas after Hurricane Sandy. Our findings can inform coherent and targeted responses to disasters. Early identification of medically vulnerable populations can help to map "hot spots" requiring additional medical and social attention and prioritize resources for areas most impacted by disasters. (Disaster Med Public Health Preparedness. 2016;page 1 of 11). Language: en
Analysis of suddenly emerging public health events and their control strategies In Meizhou City,Guangdong during 2002 to 2007

Objective To analyze the epidemiological characteristics of suddenly emerging public health events in Meizhou City to provide scientific basis for their prevention and control.Methods Data of suddenly emerging public health events from 2002 to 2007 were collected and analyzed by descriptive epidemiological method.Results There were 44 emerging public health events with 2?267 cases and 10 deaths in Meizhou City during 2002 to 2007, 20 of them caused by infectious diseases and 24 by food poisoning. The peak of events mainly was in March to June of each year and most occurred in schools (47.73%).Conclusion Situation of emerging public health events in Meizhou City was not so optimistic.More attention should be paid to prevention and control for infectious diseases and food poisoning, especially in key groups such as students, farmers, and so on.
Ureteropelvic junction obstruction. I. Observations on the classic type in adults.

AbstractA total of 111 adults underwent repair of congenital ureteropelvic junction obstruction during a 15-year period. A majority of the patients (77 per cent) presented with flank pain. In all patients established (89 per cent) or intermittent (11 per cent) hydronephrosis was demonstrated. In contrast with our former practice, a majority of the patients (86 per cent) underwent dismembered pyeloplasty with intubation. Of the 10 hypertensive patients 8 remained hypertensive postoperatively but only 3 of 22 patients with stones had recurrent calculi. The success rate was 95 per cent with 1 operation. Three patients required a second repair and 1 underwent nephrectomy. Therefore, the eventual success rate was 99 per cent.
Management of Symptomatic Severe Aortic Stenosis in Patient With Very Severe Chronic Obstructive Pulmonary Disease.

Transcatheter aortic valve replacement (TAVR) is a viable option for patients with severe chronic obstructive pulmonary disease (COPD) who are deemed inoperable or high risk for surgery. We sought to determine outcomes of patients with severe aortic stenosis (AS) and severe COPD referred for aortic valve replacement (AVR). One hundred thirty-one patients with severe AS and severe COPD (GOLD criteria) were evaluated at our center between 2008 and 2013 and were divided retrospectively into 4 groups: 1—medical management, 2—balloon aortic valvuloplasty, 3—surgical aortic valve replacement (SAVR), and 4—TAVR. Baseline, clinical, and echo data were recorded. Primary outcome was cardiovascular death. From the study cohort, 54 (41.2%), 29 (22.1%), 21 (16.0%), and 27 (20.6%) were included in groups 1-4, respectively; the age was 74.9 ± 8.8, 76.2 ± 8.8, 78.8 ± 7.4, and 82.8 ± 6.8 years, respectively ( P P = 0.719) or heart failure readmissions ( P = 0.19). In patients with severe or very severe COPD and severe AS, replacing the severely stenotic aortic valve by either SAVR or TAVR improves survival and reduces rehospitalization compared with medical therapy or balloon aortic valvuloplasty.
An Embedded Librarian Program: Eight Years On

This article examines an embedded librarian program eight years after implementation in a large academic health center. Librarians were physically moved into the colleges of pharmacy, public health, and nursing. Statistics are reported as well as comments from the participating librarians and faculty members. Strong relationships have been built between librarians, faculty members, and students. Locating the librarians among faculty and students led to a better understanding of client needs and an increased awareness of librarian competencies and services resulting in partnerships and greater utilization of library services.
Accentuate the Positive: The Influence of Kurt Lewin’s ‘Bringing Up the Jewish Child’ on Postwar American Jewish Life

This article contributes new insights into German-Jewish psychologist Kurt Lewin’s work and its considerable influence on American Jewish educational theory and practice since the 1940s. Though he died in 1947, Lewin’s theories about the emotional needs of the Jewish child and the principles of effective Jewish education continued to influence American Jewish pedagogy long after his passing. Lewin, a social psychologist who fled Hitler’s Germany in 1933 and eventually landed at MIT, argued for the importance of inculcating a notion of “group belongingness,” or attachment to the Jewish social group, in the Jewish child as a critical factor in his or her healthy emotional development. According to Lewin, positive and joyous childhood experiences with Jewish culture would shield Jewish children from debilitating feelings of inferiority and self-loathing. Rabbis and educators across the ideological spectrum relied on Lewin’s work to explain to parents how a Jewish education could help nurture happy, well-integrated American Jewish children. For American Jews in search of both acceptance and ethnic preservation, Lewin offered appealing scientific evidence of the psychic benefits of Jewish education and the potential of positive Jewish experiences to produce both proud, committed Jews and loyal American citizens. The impact of Lewin’s work on American Jewish life and thought is evident in the 2013 Pew Study, in which 94% of American Jews reported that they are proud to be Jewish.
Fines adsorption on nanoparticle-coated surface

Fluid flow through porous media is inherently associated with the detachment and migration of fine particles. The migration of fine particles and ensuing clogging is the main reason of flow rate decrease in porous media. Nanoparticle coating can be a promising method to prevent fines’ detachment and migration by changing electrical surface forces between the pore wall surface and the fine particles. In this study, the attraction and adhesion forces of the nanoparticle-coated surface are measured by atomic force microscope. The effect of the nanoparticle coating on the fines adsorption efficiency is then investigated. The results show that there is an increase in the adhesion force on the nanoparticle-coated surface and the significant improvement of the fines adsorption capacity by the nanoparticle coating. The research results are relevant to other research areas whenever migrating fines cause engineering problems.
Non-causal filtering applied to numerical whistler mode raytracing

Non causal filtering or smoothing is an important signal processing technique. In this work we implement a new non causal filter and apply it to whistler mode ray tracing platform. This smoothing technique is highly resistant to outliers; hence it helps on increasing the accuracy of the numerical results.
An application of using embedded underwater computing architectures

Underwater computing systems have recently emerged as a new technology for underwater applications. In our previous work, we employed various nodes (processing nodes, gateway nodes, and sensing nodes) that are used to construct different candidate computing architectures (i.e. single, pipeline, and hybrid of parallel/pipeline). In this paper, we use these computing architectures in a real world scenario of underwater applications. The selected application is the detection and classification of fish species in real-time. The selected application scenario proves the applicability and performance relevance of the developed computing architectures for underwater environment. Our results show that the proposed computing architectures provide high speed-up gain for the selected application.
Abstract WMP46: Histone Deacetylase Inhibitor, Sodium Butyrate, Exhibits Neuroprotective Effects in a Stroke Model of Middle-Aged Female Rats

Background and Purpose: Sodium butyrate (NaB) is recognized as a HDAC inhibitor exhibiting anti-inflammatory and neuroprotective effects in a rat ischemic model of stroke as well as a myocardial is...
Differential Brd4-bound enhancers drive critical sex differences in glioblastoma

Sex differences in the incidence and severity of numerous human diseases, including cancer, are substantial and demand an understanding at a molecular level. In an established model of Glioblastoma (GBM), we discovered transcriptome-wide sexual dimorphism in patterns of gene-expression, H3K27ac marks (ChIP-seq) and large Brd4-bound enhancers (calling cards) of the type referred to as super/stretch enhancers. Genetic depletion or pharmacological inhibition of Brd4 reproducibly abrogated the sex differences in the GBM phenotype; male cells became less clonogenic, proliferative, and tumorigenic, while female cells became more clonogenic. Finally, sexual dimorphism in Brd4 function was consistent with sex differences in the effect of low Brd4 expression on survival in GBM patients. These data establish for the first time that sex is an intrinsic element of cellular identity, and that it is driven by differential Brd4 activity, which renders male and female cells differentially sensitive to JQ1 treatment.
Predictors of Secondary Role Strains Among Spousal Caregivers of Older Adults With Functional Disability.

Background and objectives Aging spouses commonly care for a partner with functional disability, but little is known about how spousal caregiving may impact different life domains. This study evaluated how caregiving characteristics are associated with secondary role strains among spousal caregivers. Research design and methods This cross-sectional study examined 367 spousal caregivers and their partners from the 2011 National Health and Aging Trends Study and National Study of Caregiving. Hierarchical regressions were estimated to determine how caregiver background factors (sociodemographics, health conditions) along with primary objective (care activities, care recipient health conditions, and dementia status) and subjective (emotional caregiving difficulties, role overload) stressors are linked to care-related valued activity restriction, negative caregiving relationship quality, and care-related family disagreements. Gender differences were considered. Results After accounting for all predictors, older caregivers and caregivers providing more help with activities of daily living and health system interactions (e.g., scheduling appointments) were more likely to report activity restriction, whereas caregivers with more emotional difficulties reported higher negative caregiving relationship quality. Role overload was positively associated with all three secondary strains. For husbands only, caring for a partner with more chronic conditions was linked to higher negative caregiving relationship quality and caring for a partner with dementia was associated with a greater likelihood of family disagreements. Discussion and implications Secondary role strains may develop through similar and unique pathways for caregiving wives and husbands. Further research is needed to identify those who could benefit from support in managing their care responsibilities alongside other life areas.
Long-term outcomes following proton therapy for prostate cancer in young men with a focus on sexual health.

AbstractBackground: We investigated long-term outcomes for men ≤60 years old treated with proton therapy (PT).Methods: Of 254 men ≤60 years old were treated with proton therapy alone for prostate cancer. Risk stratification included 56% with low-, 42% with intermediate- and 2% with high-risk disease. Patients received 76–82 Gy at 2 Gy/fraction or 70–72.5 Gy at 2.5 Gy/fraction. Before treatment and every 6–12 months for 5 years, patients were evaluated by a physician, answered health-related quality of life surveys, including the EPIC, IIEF and IPSS, and had PSA evaluated.Results: Median follow-up for the cohort was 7.1 years; 7-year biochemical-free survival was 97.8%. Eight men (one high-risk; five intermediate-risk and two low-risk) experienced biochemical progression, including one who died of disease 9 years after treatment. Potency (erections firm enough for sexual intercourse) was 90% at baseline and declined to 72% at the first-year follow-up, but declined to only 67% at 5 years. Only 2% of patient...
Management of Non-Diffuse Large B Cell Lymphoma Post-Transplant Lymphoproliferative Disorder

Post-transplant lymphoproliferative disorder (PTLD) is one of the most common neoplasms seen after solid organ and hematopoietic stem cell transplantation, and is associated with significant morbidity and mortality. The pathogenesis is related to post-transplant immunosuppression and EBV infection. Prevention of PTLD depends upon judicious use of immunosuppression and serial EBV monitoring. Preemptive therapy consists of reduction of immunosuppression, antiviral medications, and single-agent rituximab. There are no randomized phase III trials on PTLD treatment, so current management guidelines are largely based on recent phase II trials, single-institution retrospective studies, and expert opinion. Management of PTLD is dependent upon its subtypes. Early-type and polymorphic PTLD generally respond to reduction of immunosuppression and rituximab monotherapy, whereas monomorphic PTLD often requires additional concurrent or sequential use of chemotherapy. For rare subtypes of PTLD, standard-of-care guidelines for de novo lymphomas are recommended. Surgical resection or radiotherapy may be used as adjunctive therapy depending on the extent of disease. Non-chemotherapy options such as adoptive T cell therapy have shown promising efficacy and must be explored further. Despite progress in the last decade, overall survival rates continue to be low in published series. This review highlights the need for prospective randomized trials incorporating novel agents to improve outcomes in PTLD.
Vertical profiles of cloud condensation nuclei from a balloon-borne instrument

Publisher Summary Beyond the basic facts that cloud condensation nuclei (CCN) are primary factors in cloud and precipitation formation, in cloud radiation properties, in chemical processes within clouds and related phenomena, and the fundamental understanding of the relationship between physicochemical aerosol properties and CCN activity, significant questions remain regarding the sources, actual composition, transformations, and residence times of CCN. The data base available for analyzing such questions is growing, but the diversity and complexities of the atmosphere require that data from a wide range of conditions be acquired with increased flexibility in the measuring systems used. The data presented in this chapter are principally intended to demonstrate the feasibility of CCN measurements by a balloon-borne instrument. Volatility of the CCN and of the other aerosol is also determined. These data show that substantial fractions of the tropospheric aerosol sampled on 26 September, 1995 contained volatile components, up to 95% in number, or 50% in volume, or some combination of changes in both, in limited altitude layers.
Review of Thrombocytopenia and Perioperative Management in Dentistry

Thrombocytopenia may be caused by a variety of underlying systemic diseases. Mechanisms resulting in low levels of circulating platelets can be categorized into three categories: decrease in platelet production, an increase in platelet sequestration, or peripheral destruction of platelets. Peripheral platelet destruction may be further classified as immune or nonimmune mediated. The management of thrombocytopenia is based on the severity of the underling systemic disorder and clinical extent of the bleeding. A detailed history and physical exam, review of laboratory values, and scope of the anticipated dental procedure will determine the optimal perioperative management of the thrombocytopenic patient.
Superior Capsular Reconstruction With Arthroscopic Rotator Cuff Repair in a "Functional Biologic Augmentation" Technique to Treat Massive Atrophic Rotator Cuff Tears.

Abstract Surgical treatment of patients with massive rotator cuff tears is unpredictable because of a low healing rate and high incidence of clinical failure. Arthroscopic superior capsular reconstruction has emerged as a promising technique in treating younger, active patients with massive irreparable rotator cuff tears. Superior capsular insufficiency has been theorized to be a factor in the higher failure rate for repairs of massive tears, and there have been proposals of superior capsular repair in addition to rotator cuff repair to facilitate better healing of massive rotator cuff tears. This article presents our technique of functional rotator cuff augmentation, which is concomitant superior capsular reconstruction with arthroscopic rotator cuff repair, to treat massive, atrophic rotator cuff tears. This technique is used in patients with massive rotator cuff tears and superior capsular insufficiency.
Adrenal vein sampling: How i do it

Adrenal vein sampling (AVS) is an uncommonly performed interventional procedure. However, it is essential in the management of patients with primary aldosteronism and several other rare hormonal disorders. AVS can be technically challenging, largely from difficulty with right adrenal vein catheterization. Recently described technical modifications have improved the likelihood of successful sampling in every case. This paper highlights the author's approach to patient selection and step-by-step details of his technique.
Disentangling spin-orbit coupling and local magnetism in a quasi-two-dimensional electron system

Quantum interference between time-reversed electron paths in two dimensions (2D) leads to the well-known weak localization correction to resistance. If spin-orbit coupling is present, the resistance correction is negative, termed weak antilocalization (WAL). Here, we report the observation of WAL coexisting with exchange coupling between itinerant electrons and localized magnetic moments. We use low-temperature magnetotransport measurements to investigate the quasi-two-dimensional, high-electron-density interface formed between ${\mathrm{SrTiO}}_{3}$ and the antiferromagnetic Mott insulator ${\mathrm{NdTiO}}_{3}$. As the magnetic field angle is gradually tilted away from the sample normal, the data reveal the interplay between strong $k$-cubic Rashba-type spin-orbit coupling and a substantial magnetic exchange interaction from local magnetic regions. The resulting quantum corrections to the conduction are in excellent agreement with existing models and allow sensitive determination of the small magnetic moments ($22\phantom{\rule{0.16em}{0ex}}{\ensuremath{\mu}}_{B}$ on average), their magnetic anisotropy, and mutual coupling strength. This effect is expected to arise in other 2D magnetic materials systems.
High performance perovskites solar cells by hybrid perovskites co-crystallized with poly(ethylene oxide)

Abstract Hybrid perovskite materials have emerged as attractive alternatives for cost-effective solar cells in the past ten years. However, achieving hysteresis-free, stable and efficient solution-processed perovskites solar cells has remained as a significant fundamental challenge. In this study, we report a strategy that utilizes poly (ethylene oxide) to sequester the counter ions in the perovskite lattices to suppress the formation of point defects, reduce the migration of ions/vacancy and to facilitate crystal growth in a more thermodynamically preferred orientation. Systematical investigations indicate that poly (ethylene oxide) indeed form hydrogen bonds with perovskite, which reduces the formation of kinetically-driven point defects, minimize charge carrier recombination and sharpen the density of states distribution. As a result, un-encapsulated solution-processed perovskite solar cells exhibit stabilized power conversion efficiency with hysteresis-free characteristics and significantly improved ambient shelf- and thermal-stability at relative high humidity, in comparison to the reference devices that exhibit unstable power conversion efficiency with dramatically higher hysteresis factor and poorer device lifetime. Our studies demonstrate that development of hybrid perovskite materials co-crystallized with polymers is an efficient approach towards high performance perovskite solar cells.