cssi/SciSciGPT-SciSciNet huggingface dataset:
Executive functions in girls with and without childhood ADHD: developmental trajectories and associations with symptom change

Background We prospectively followed an ethnically and socioeconomically diverse sample of girls with attention-deficit/hyperactivity disorder (ADHD) (n = 140) and a matched comparison sample (n = 88) from childhood through young adulthood to evaluate developmental trajectories of executive functions (EF) and associations between EF trajectories and dimensional measures of ADHD symptoms. We hypothesized that (a) EF trajectories would be similar in girls both with and without childhood ADHD, with the ADHD group showing greater impairment across time; and (b) changes in EF abilities would predict changes in ADHD symptoms across time, consistent with the theory that ADHD symptom reductions partially result from prefrontally mediated EF development. Method Latent growth curve models were used to evaluate development of sustained attention, response inhibition, working memory, and global EF abilities, and associations between EF trajectories and ADHD symptom trajectories. Results Girls with childhood-diagnosed ADHD showed greater improvement across development on measures of sustained attention and global EF, but similar rates of improvement on measures of working memory and response inhibition. Changes in the global EF measure predicted changes in both inattentive and hyperactive-impulsive symptoms across time, whereas changes in response inhibition predicted changes in hyperactive-impulsive symptoms; associations between changes in other EF variables and symptoms were not significant. Conclusions Findings suggest variability in patterns of EF improvement over time in females with ADHD histories and indicate that EF development may play a role in symptom change.
Methyltert-Butyl Ether Causes α2u-Globulin Nephropathy and Enhanced Renal Cell Proliferation in Male Fischer-344 Rats

Methyltert-butyl ether (MTBE), a fuel additive blended into unleaded gasoline to decrease carbon monoxide emissions, induces renal tumors in male, but not female, rats exposed by inhalation to ≥3000 ppm MTBE. A number of chemicals that induce male rat-specific renal tumors also cause a syndrome unique to male rats referred to as α2u-globulin nephropathy (α2u-N). The objective of the present study was to determine if MTBE induces an α2u-N and renal cell proliferation in male F-344 rats. Male and female F-344 rats were exposed to MTBE vapors of 0, 413, 1516, or 3013 ppm for 6 hr/day for 10 consecutive days. Significant proximal tubule necrosis and protein droplet accumulation were observed in kidneys from male rats exposed to 1516 and 3013 ppm MTBE. Significantly greater labeling indices were observed in all groups of MTBE-exposed male rats. α2u-Globulin immunoreactivity was present in and confined to protein droplets in male rat kidney. A mild dose-related increase in α2u concentration in the kidney, as measured by an enzyme-linked immunosorbent assay, was observed in male rats exposed to MTBE, with a statistically significant increase in α2u concentration in male rats exposed to 3013 ppm MTBE. There was a strong positive correlation (r= 0.994) with exposure concentration between cell proliferation and α2u concentration in male rat kidney. No significant differences were observed in female rats for any of these responses. Further analysis of kidney cytosol failed to demonstrate the accumulation of any protein besides α2u in MTBE-exposed male rat kidney. These findings demonstrate that MTBE causes a mild induction of α2u-N and enhanced renal cell proliferation in male, but not female, F-344 rats, suggesting a role for α2u-N in renal tumorigenesis.
Airship Waypoint Navigation in the Presence of Wind

develops a guidance and control system for a small airship to y through assigned waypoints in three dimensional space with a desired speed in the presence of wind and wind gust. In the control system development and validation, a simulation environment based on the nonlinear 6-DOF model of an airship, including the eect of the wind, is used. The controller design is based on MIMO (Multi-Input Multi-Output) LQR (Linear Quadratic Regulator) method. A gain scheduling scheme is used to cover multiple operating conditions based on the forward speed. Nonlinear simulations for dierent scenarios are performed and results are discussed. The simulation experiments show that the airship can y through the assigned waypoints, even when the way points are at dierent altitudes, when the commanded speed is constant or commanded speed is changed when the commanded altitude is kept constant.
Enhancing Research Productivity in Counseling Psychology Reactions to Three Perspectives

The present reaction responds to the three research-related core articles in the Scientific Forum of the May 2005 issue of The Counseling Psychologist. I agree that too few of our studies are based on theories or models. Using the nomological network, I suggest how research ideas can more readily be depicted to allow model and theory testing. I comment on some aspects of structural equation modeling and note the usefulness of analyzing how we can improve our use of this increasingly popular method. Finally, I note the striking findings of institutional mobility, both upward and downward, in research productivity and suggest that in-depth analysis of a few of the most dramatic moves might help to explain these findings.
Efficient and effective grasping of novel objects through learning and adapting a knowledge base

This paper introduces a new approach to establish a good grasp for a novel object quickly. A comprehensive knowledge base for grasping is learned that takes into account the geometrical and physical knowledge of grasping. To automate the learning process as much as possible, learning happens in a virtual environment. We used the GraspIt! simulation environment with the Barrett hand for this work. As only approximate features of objects are used for training the grasping knowledge base (GKB), the knowledge gained is rather robust to object uncertainty. Based on the guidance of the GKB, a suitable grasp for a novel object can be found quickly. The newly gained grasping information of the new object can also be feedback to the GKB so that the knowledge base continues to improve as it is exposed to more grasping cases. The GKB serves as the ldquoexperiencerdquo of the robotic gripper to make grasping more and more skillful. We implemented the approach and tested it on This paper introduces a new approach to establish a good grasp for a novel object quickly. A comprehensive knowledge base for grasping is learned that takes into account the geometrical and physical knowledge of grasping. To automate the learning process as much as possible, learning happens in a virtual environment. We used the GraspIt! [T. Miller and P.K. Allen, 2000] simulation environment with the Barrett hand for this work. As only approximate features of objects are used for training the grasping knowledge base (GKB), the knowledge gained is rather robust to object uncertainty. Based on the guidance of the GKB, a suitable grasp for a novel object can be found quickly. The newly gained grasping information of the new object can also be feedback to the GKB so that the knowledge base continues to improve as it is exposed to more grasping cases. The GKB serves as the ldquoexperiencerdquo of the robotic gripper to make grasping more and more skillful. We implemented the approach and tested it on a wide variety of objects. The results show the effectiveness of this approach to achieve quick and good grasps of novel objects.a wide variety of objects. The results show the effectiveness of this approach to achieve quick and good grasps of novel objects.
Modular microfluidics for point-of-care protein purifications

Biochemical separations are the heart of diagnostic assays and purification methods for biologics. On-chip miniaturization and modularization of separation procedures will enable the development of customized, portable devices for personalized health-care diagnostics and point-of-use production of treatments. In this report, we describe the design and fabrication of miniature ion exchange, size exclusion and affinity chromatography modules for on-chip clean-up of recombinantly-produced proteins. Our results demonstrate that these common separations techniques can be implemented in microfluidic modules with performance comparable to conventional approaches. We introduce embedded 3-D microfluidic interconnects for integrating micro-scale separation modules that can be arranged and reconfigured to suit a variety of fluidic operations or biochemical processes. We demonstrate the utility of the modular approach with a platform for the enrichment of enhanced green fluorescent protein (eGFP) from Escherichia coli lysate through integrated affinity and size-exclusion chromatography modules.
An adaptive vector quantizer based on the Gold-Washing method for image compression

The VLSI architecture for an adaptive vector quantizer is presented. The adaptive vector quantization method does not require a-priori knowledge of the source statistics and the pre-trained codebook. The codebook is generated on the fly and is constantly updated to capture local textual features of data. The source data are directly compressed without requiring the generation of codebook in a separate pass. The adaptive method is based on backward adaption without any side information. The speed of data compression by using the proposed adaptive method is much faster than that by using the conventional vector quantization methods. The algorithm is shown to reach the rate distortion function for memoryless sources. In image processing, most smooth regions are matched by the code vectors and most edge data are preserved by using the block-data interpolation scheme. The VLSI architecture consists of two move-to-front vector quantizers and an index generator. It explores parallelism in the direction of the codebook size and pipelining in the direction of the vector dimension. According to the circuit simulations using the popular SPICE program, the computation power of the move-to-front vector quantizer can reach 40 billion operations per second at a system clock of 100 MHz by using 0.8 /spl mu/m CMOS technology. It can provide a computing capability of 50 Mpixels per second for high-speed image compression. The proposed algorithm and architecture can lead to the development of a high-speed image compressor with great local adaptivity, minimized complexity, and fairly good compression ratio. >
On the core of agents interactions in a spontaneous networked organization

In many dynamic open systems, social interaction plays an important role for the development of social capital. These interactions may not be secure from self-interested agents. For that, each agent must be capable of identifying reliable interaction allies. In light of this, the focus is on developing a different type of interaction among the agents inside a spontaneous networked organization (SNO). It helps to overcome such a problem through applying a broad range of service level agreements (SLAs). SLA and its role amongst the agents in the SNO will be discussed. We will present a policy of negotiation to accelerate the execution process of the fittest task provided by the organizer. Moreover, by applying collaborative filtering (CF), we examine different types of data to show how agents interact implicitly or explicitly and how these interactions affect the social capital. This method obtains a high performance of interaction and can help to control the spontaneous flow of behaviors and knowledge to be more accurate when agents communicate rationally since trust is recorded in such a distributed organization.
Structure of the Yeast Hst2 Protein Deacetylase in Ternary Complex with 2′-O-Acetyl ADP Ribose and Histone Peptide

Abstract Sir2 proteins are NAD + -dependant protein deactylases that have been implicated in playing roles in gene silencing, DNA repair, genome stability, longevity, metabolism, and cell physiology. To define the mechanism of Sir2 activity, we report the 1.5 A crystal structure of the yeast Hst2 (yHst2) Sir2 protein in ternary complex with 2′-O-acetyl ADP ribose and an acetylated histone H4 peptide. The structure captures both ligands meeting within an enclosed tunnel between the small and large domains of the catalytic protein core and permits the assignment of a detailed catalytic mechanism for the Sir2 proteins that is consistent with solution and enzymatic studies. Comparison of the ternary complex with the yHst2/NAD + complex, also reported here, and nascent yHst2 structure also reveals that NAD + binding accompanies intramolecular loop rearrangement for more stable NAD + and acetyl-lysine binding, and that acetyl-lysine peptide binding induces a trimer-monomer protein transition involving nonconserved Sir2 residues .
Performance Analysis of Metamaterial Substrate Based MIMO Antenna Arrays

A rectangular patch antenna array for MIMO communications was simulated on a magnetic permeability enhanced metamaterial. The performance of this antenna array was studied relative to a similar array constructed on a regular substrate. The analysis was performed with respect to performance metrics such as degree of mutual coupling for different element spacing, achievable channel capacity, bandwidth and efficiency. The array built on the metamaterial substrate showed significant size reduction, less mutual coupling and significant channel capacity improvement compared to similar arrays on conventional substrates.
All You Need to Know About Urethrovesical Anastomotic Urinary Leakage Following Radical Prostatectomy

Purpose: Radical prostatectomy is a challenging operation demanding a high level of surgical expertise and experience. Urinary leakage at the urethrovesical anastomosis is one of the most common short-term complications of radical prostatectomy, reaching an incidence of 0.3% to 15.4%. In this review we investigate and discuss all matters directly related to urethrovesical anastomotic leak, specifically how to diagnose it properly, how to determine when it is clinically significant and when intervention is required, how to prevent or predict it and, finally, the possible long-term sequelae.Materials and Methods: We conducted a systematic analysis of the literature searching for English and nonEnglish language publications from a preidentified time frame (1985 to 2011) using primary search databases (PubMed®, Web of Science®). Manual selection was performed by 2 authors and the third reviewed the final common selection. We also created an algorithm for the diagnosis and management of urethrovesical anastomo...
Efficient Design of Microstrip Antennas for SDR Applications Using Modified PSO Algorithm

In this paper, several irregularly shaped microstrip antenna structures are designed using a new version of Binary Particle Swarm Optimization (BPSO) algorithm in which the velocity calculation is modified towards a more accelerated and still robust search procedure, particularly aimed for software-defined radio (SDR) applications. The optimization results are compared using both the modified and the conventional BPSO algorithms. Pros and cons are studied in terms of optimization length, convergence speed and final design conformability to desired objectives. It is depicted that the modified BPSO achieves the design criterion considerably faster than the conventional one, at the cost of slightly limiting particle exploration ability.
Conjoined twins: Morphogenesis of the heart and a review

Five cases of conjoined twins have been studied. These included three thoracopagus twins, one monocephalus diprosopus (prosop = face), and one dicephalus dipus dibrachus. The thoracopagus twins were conjoined only from the upper thorax to the umbilicus with a normal foregut. These three cases shared a single complex multiventricular heart, one with a four chambered heart with one atrium and one ventricle belonging to each twin with complex venous and arterial connection; two had a seven chambered heart with four atria and three ventricles. The mono-cephalus diprosopus twins had a single heart with tetralogy of Fallot. The dicephalus twins had two separate axial skeletons to the sacrum, two separate hearts were connected between the right atria with a shared inferior vena cava. Thoracopagus twinning is associated with complex cardiac malformations. The cardiac anlagen in cephalopagus or diprosopus are diverted and divided along with the entire rostral end of the embryonic disc and result in two relatively normal shared hearts. However, in thoracopagus twins the single heart is multiventricular and suggests very early union with fusion of the cardiac anlagen before significant differentiation. Cardiac morphogenesis in conjoined twins therefore appears to depend on the site of the conjoined fusion and the temporal and spatial influence that determines morphogenesis as well as abnormally oriented embryonic axes.
Remotely-sensed indicators for monitoring the general condition of "natural habitat" in watersheds: an application for Delaware's Nanticoke River watershed

Over the past two decades there has been increasing interest in developing indicators to monitor environmental change. Remote sensing techniques have been primarily used to generate information on land use/land cover changes. The US Fish and Wildlife Service has used this technology to monitor wetland trends and recently developed a set of remotely-sensed indicators to characterize and assess trends in the integrity of natural habitat in watersheds. The indices largely focus on the extent of “natural” cover throughout a given watershed, with an emphasis on locations important to fish, wildlife, and water quality. Six indices address natural habitat extent and four deal with human-caused disturbance. A composite index of natural habitat integrity combining the habitat extent and habitat disturbance indices may be formulated to provide an overall numeric value for a watershed or subbasin. These indices facilitate comparison between watersheds (and subbasins) and assesssment of trends useful for environmental monitoring. This paper describes the indices and presents an example of their application for characterizing and assessing conditions of subbasins within Delaware’s Nanticoke River watershed. © 2004 Published by Elsevier Ltd.
An Assessment of Coliform Bacteria in Water Sources Near Appalachian Trail Shelters Within the Great Smoky Mountains National Park

Objective Hikers and campers are exposed to risks while in the wilderness. One of these risks is the possibility of contracting an illness, including infectious diarrhea. This project tested for coliform bacteria in water samples taken near popular Appalachian Trail shelters. Methods Water was collected from access points within the Great Smoky Mountains National Park. Samples were collected in sterile bottles and inoculated on a commercially available coliform detection kit for quantitative determination of total coliform and Escherichia coli counts. Results Water samples were taken during summer and fall seasons. During summer, 7 of 10 samples were positive for coliform bacteria and 6 of those 7 for E coli . The most probable number (MPN) of colony-forming units (CFU) for coliform bacteria ranged from 0 to 489 CFU/100 mL, with the MPN for E coli varying from 0 to 123 CFU/100 mL. These data differed from the fall collection, revealing 3 of 7 samples positive for coliform bacteria and 1 of those 3 for E coli. The MPN of CFU for coliform bacteria in fall samples varied from 0 to 119 CFU/100 mL and 0 to 5 to CFU/100 mL for E coli. Conclusions Environmental Protection Agency drinking water standards set the standard of 0 CFU/100 mL to be considered safe. This analysis of water samples along the Appalachian Trail emphasizes that the majority of water access points require treatment during the summer season. Coliform burden was not as high through the fall months. These data suggest one infectious disease risk for wilderness travelers.
Offshore Wind Power Potential

The offshore region has been cited as a location to construct wind energy conversion systems because this region offers reduced surface drag; therefore, higher wind speeds and greater wind power may be harnessed than on land. A result of a statistical analysis of wind speed records for the Gulf of Maine region shows that six seasonal wind groups can be identified and that the gamma distribution adequately describes the wind speed frequency. The results show that for six months of the year higher wind speeds can be obtained offshore than inland. The use of the gamma distribution of wind speed for the operational characteristics of wind turbines show there is questionable gain in operating a turbine in an offshore environment. Historical wind speed records of the Boston Logan Airport, the Boston Lightship, and data collected on board ships that traversed the Gulf of Maine region were used in the study.
Book review: Marxist Essays on Neoliberalism, Class, ‘Race’, Capitalism and Education, by Dave Hill

Dave Hill Marxist Essays on Neoliberalism, Class, 'Race', Capitalism and Education, Institute for Education Policy Studies, Brighton, 2013; 204 pp.; 9780952204220, 15 [pounds sterling]. This small volume is a compilation of seven essays authored or co-authored by the British classical Marxist scholar/activist Dave Hill. Most were published in the Journal for Critical Education Policy Studies, of which he is the chief editor. Central to Hill's arguments is the need to return to a Marxist analysis of capital-labour relations as it pertains to the study of education in the UK and abroad (p. 7). Far too often, Hill argues, scholars of education deny a Marxist class analysis, substituting in its place an understanding of class as an effect of culture, or else a Weberian 'market situation' definition of class (p. 35). He also critiques 'parallelist' and 'tryptarch' models of inequality that equate class, gender and race. Hill argues that these analyses conceal labour relations and material inequalities within (p. 144). Hill contends that in order to understand the neoliberal restructuring of schools and pedagogy, one must understand the Marxist critique that education is inherently tied to existing political and economic structures. Because the articles were originally published separately and make similar arguments, the chapters can seem a bit repetitive. That being said, there are two articles worth noting. Hill's fifth chapter, 'Globalisation and its educational discontents: Neoliberalism and its impacts on education workers' rights, pay and conditions', serves to contextualize some of the Marxist critiques of education under capitalism. Hill identifies 'Three educational plans of capital' (pp. 116-7): (1) 'Produce and reproduce a work force, citizenry and set of consumers fit for capital'; (2) 'Smooth the way for direct profit-taking/profiteering from education'; (3) Increase privatization of schools and support industries, and increase investment by multinational corporations and 'Edu-businesses'. He argues that one can contextualise these 'plans' through a Marxist analysis of capital-labour relations: under neoliberalism, education is mirroring other 'service industries' which support, amplify and sustain the extraction of surplus value. In the seventh chapter, 'Immiseradon capitalism, activism and education: Resistance, revolt and revenge', Hill identifies sixteen ways in which neoliberalism and austerity capitalism have restructured schools and education (pp. 172-4): 1. The privatisation/pre-privatisation of schooling, such as the development of charter schools. …
“Men Wanted” Heterosexual Aesthetic Labor in the Masculinization of the Hair Salon

This article builds heterosexuality into the concept of aesthetic labor to better understand corporate efforts to construct gendered brands and consumer identities. By theorizing heterosexual aesthetic labor, I show how two men’s salons, Adonis and The Executive, hire for, develop, and mobilize the sexual identities and gender habitus of straight and conventionally feminine women to masculinize the hair salon. Drawing from ethnographic observations of and interviews with employees and clients at these men’s salons, I move the discussion of aesthetic labor beyond recruitment to show how service workers become interactional resources for customers’ projections of privileged identities. Emphasizing workers’ agency, I show how the women deploy professionalizing rhetoric and protocols and essentializing frameworks to manage the dilemmas of heterosexual aesthetic labor. These management strategies allow women a sense of legitimacy and at the same time keep gender and sexual hierarchies intact and naturalize men...
Calculation of the Electronic Structure of Silicon Nanocrystals

The densities of states for Si nanocrystals with diameters between 15 and 35 A are calculated using a time-dependent algorithm within the tight-binding approximation [1]. The calculated effects of surface termination and surface relaxation on the electronic properties of Si are shown. The variation in band-gap with cluster size is calculated for clusters up to 60 A in diameter.
Collision time measurements in a sonoluminescing microplasma with a large plasma parameter.

Sound-stimulated gas bubbles in liquid become tiny plasmas and may provide a test bed for plasma physics theories.
How Do Nonreproductive Groups Affect Population Growth

I describe several models of population dynamics, both unstructured and gender structured, that include groups of individuals who do not reproduce. I analyze the effect that the nonreproductive group may have on the dynamics of the whole population in terms of the vital rates and the proportion of nonreproductive individuals, and we provide specific examples for real populations.
Removal of Fluoride Ion by La (III) - loaded Chelating Resin Having Phosphonomethylamino Groups

Adsorption characteristics of La (III) -loaded chelating resin containing phosphono-methylamino groups for fluoride ion and application to the selective removal of fluoride ion have been studied. The adsorption of fluride ion depends on the pH of the solution i. e., the capacity and the adsorption rate increase with decrease of the pH. But when the pH is less than 3.5, gradual leaking of La (III) inevitably takes place. Therefore, pH 3.5 is chosen as the optimal adsorption condition of the solution. Fluoride ion is effectively adsobed on the column packed with La (III) -loaded resin at pH 3.5. No significant interference from Cl-, NO3- and SO42- were observed. The retained fluoride ion has been released from the column by elution with 1mol⋅dm-3 sodium hydroxide solution without any leakage of the metal ion. The column can be used repeatedly after regeneration.
A Psychometric Development of a Test for Consumer Alienation from the Marketplace

Alienation has interested philosophers and researchers for many years, but only recently has empirical study been directed toward consumer alienation from the marketplace. The author reports the de...
The Anatomy of a Train Wreck

Let us next draw some parallels between the past and the present. The similarities between the Roaring Twenties and the 1990s are striking. Perhaps most striking is the dramatically increased pattern of stock market participation by the average Consumer-Investor.
Investigation on Plerocercoid Infection in Frogs and Snakes in Nanning Guangxi

The prevalence of plerocercoid infection in frogs and snakes was investigated in Nanning of Guangxi,China.During the period of November 2011 to September 2012,632frogs and 158 snakes were bought from markets in Nanning and examined for the infection of plerocercoids.The examined frogs consisted of 617 Rana limnocharis and 15 other species,while the examined snakes consisted of 49 Naja atra,105 Ptyas mucosus and 4 other species.Cats were infected with collected plerocercoids for obtaining the adult worms.The average infection rate in frogs was 10.92%and the infection rate in R.limnocharis was 11.18%.The infection intensity in frogs was 1-24 plerocercoids per frog.The average infection rate in snakes was 22.15%,and the infection rate in N.atra,P.mucosus and the other species were 8.16%,29.52%and 0,respectively.The infection intensity in N.atraand P.mucosus were 1and 1-208 plerocercoids per snake,respectively.The adult worms collected form cats were identified as Spirometra erinaceieuropaei.The infection rate of plerocercoids in frogs and snakes in Nanning is high,which poses a threat to the health of local people.
First-time parents' shared representation of postpartum depressive symptoms: A qualitative analysis.

Abstract Rationale Maternal postpartum depression (PD) is a common, debilitating mental health problem. Yet despite effective treatments and widespread screening, treatment rates remain low. Previous studies suggest fathers are frequently consulted about maternal PD symptoms, but little is known about the process, content, or outcomes of these consultations. Objective The aim of this work was to explore how couples communicate about PD symptoms. Methods: A single purposive sample of first-time parents stratified by maternal depression screening scores (Edinburgh Postnatal Depression Scale; EPDS) and partner status was drawn from a prospective survey of 300 parents in the U.S. Midwest. Partnered mothers with an elevated (EPDS≥10) depression screening score at one of four time points in the postpartum year comprised the majority of the sample. Smaller samples of participants with low EPDS scores and single participants were included to provide contrast in the consultation and decision making process. A total of 39 participants (22 married/EPDS-high, 10 married/EPDS-low, 5 single/ EPDS-high, 2 single/EPDS-low) were interviewed at one year postpartum. Mothers and fathers were interviewed separately to promote candid responses and allow comparison of illness conceptualizations. Interviews were transcribed, analyzed, and coded through an iterative process. Results Couples’ conversations about mood changes centered on two overarching questions: How bad is it? and What should we do about it? Answering How bad is it? involved parents comparing maternal mood changes to uncertain depression criteria, and mothers asking partners and female relatives whether changes were normal. Answering What should we do about it? had three themes: Fathers feeling unprepared to respond to depression, mothers and fathers expressing reluctance to seek treatment, and couples working collaboratively to accommodate treatment or self-care. Conclusion Themes suggest partners significantly contribute to women’s conceptualization of mood changes and should be actively engaged in education, screening, and referral practices.
Scorning the Image of Virtue: The Player Nathan Field’s Letter to the Reverend Thomas Sutton, 1616

There survives an extraordinary letter of 1616 by the prominent English stage player, Nathan Field. His missive is one of the only extant apologies for the theater written by a player. Field’s letter is a response to a sermon preached by Thomas Sutton, and it richly characterizes Field’s relationship to his parish and to the larger ecclesial powers. This discussion shows how Field ironically employs the very charges often levied by opponents of theater—deception, emotional indulgence, and idolatry—to indict Sutton for a public attack he wielded against Field from the Sunday pulpit. Field’s apology is read within the context of the era’s antitheatricalist polemics, Jacobean politics, Reformation theology, and Field’s history as the son of a radical puritan preacher. The letter invites deep consideration of church and theater—preaching and playing—as competing kinds of performance. Field’s apology also focuses attention on a neglected area in theater studies—the history of players and playing in early modernity. What was an actor’s idea of himself at a time when his profession was redefined by religious reforms? Further, this discussion offers preliminary suggestions for an early modern aesthetics of performance by inviting a dialogue between the era’s extreme antitheatricalism and concurrent prescriptions for effective oratory.
Time-resolved photoelectron imaging of iodide-nitromethane (I-·CH3NO2) photodissociation dynamics

Femtosecond time-resolved photoelectron spectroscopy is used to probe the decay channels of iodide–nitromethane (I−·CH3NO2) binary clusters photoexcited at 3.56 eV, near the vertical detachment energy (VDE) of the cluster. The production of I− is observed, and its photoelectron signal exhibits a mono-exponential rise time of 21 ± 1 ps. Previous work has shown that excitation near the VDE of the I−·CH3NO2 complex transfers an electron from iodide to form a dipole-bound state of CH3NO2− that rapidly converts to a valence bound (VB) anion. The long appearance time for the I− fragment suggests that the VB anion decays by back transfer of the excess electron to iodide, reforming the I−·CH3NO2 anion and resulting in evaporation of iodide. Comparison of the measured lifetime to that predicted by RRKM theory suggests that the dissociation rate is limited by intramolecular vibrational energy redistribution in the re-formed anion between the high frequency CH3NO2 vibrational modes and the much lower frequency intermolecular I−·CH3NO2 stretch and bends, the predominant modes involved in cluster dissociation to form I−. Evidence for a weak channel identified as HI + CH2NO2− is also observed.
Justice Scalia and the Legislative Process

For two generations, the Legal Process school of interpretation supplied the dominant framework for understanding statutory interpretation. At the most basic level, those materials instructed judges (a) to assume that the legislature consisted of “reasonable persons pursuing reasonable purposes reasonably” and (b) to interpret statutes accordingly. This essay examines ways in which Justice Scalia challenged this consensus. In particular, Justice Scalia emphasized that all legislation is as filtered through the complex processes that our Constitution prescribes for reducing policy impulses into binding law. Those processes consist of the steep requirements of bicameralism and presentment and the various rules of procedure that each House has adopted pursuant to its Article I authority to do so. According to Justice Scalia, those procedures deliberately make it difficult to enact legislation. This feature, in turn, accords to political minorities extraordinary power to block legislation or insist upon compromise as the price of assent. Sometimes the resulting compromises will be awkward because proponents of legislation must accept half a loaf. Hence, said Justice Scalia, to assume that laws are reasonable and coherent (as the Legal Process school did) is to deny the realities of the legislative process and to give short shrift to the very possibility of legislative compromise.
SPAN-Xb Expression in Myeloma Cells Can Be Upregulated by Pharmacologics.

SPAN-Xb is a spermatid-specific protein. We recently identified SPAN-Xb as a novel Cancer-Testis (CT) antigen in multiple myeloma (MM) (Blood2003; 101: 955–960) and that it frequently elicited immune responses in vivo in these patients, suggesting that SPAN-Xb may be a suitable target for immunotherapy of MM. SPAN-Xb, however, was only detected in the tumor cells from 20% of MM patients. To increase the applicability of a SPAN-Xb tumor vaccine for MM, we have set out to determine if SPAN-Xb expression could be upregulated by pharmacologics in 8 MM cell lines. Since most CT antigen expression occurs due to promoter demethylation, we first determined the ability of a hypomethylating agent, 5-azacytidine, to upregulate SPAN-Xb expression. Prior to exposure to 5-azacytidine, SPAN-Xb transcripts were only detected by RT-PCR in ARP-1 and RPMI 8226 cells. Following incubation in 5-azacytidine (2 uM) for 96 hours, the levels of SPAN-Xb transcripts were upregulated, as determined by RT-PCR and real time PCR, in all MM cell lines (ARK-B, ARP-1, H929, IM9, MM1-R, RPMI 8226 and U266) except KMS-11 (Table 1). This was associated with a corresponding increase in the level of SPAN-Xb protein expression, as shown by immunocytochemistry using a murine monoclonal antibody directed at SPAN-Xb. We next determined if SPAN-Xb gene expression could be increased by cytokine pre-incubation of these cells. IL-2 (100 IU/ml) and IL-4 (1000 IU/ml) did not affect SPAN-Xb gene expression. On their own, IL-7 (0.1 ng/ml) and GM-CSF (10 U/ml) did not affect SPAN-Xb gene expression significantly. However, when combined, especially with 5-azacytidine, a summative effect of these pharmacologics on SPAN-Xb gene expression, as determined by real time PCR, was observed in IM9 cells (Table 2). Our results indicate the potential to upregulate SPAN-Xb expression in MM for therapeutic purpose using 5-azacytidine, GM-CSF and IL-7 and provide insight into the possible mechanisms of regulation of SPAN-Xb gene expression. Table 1 Table 2
Pacem: Kennedy Brooks

This two-part negotiation exercise is used in Negotiations electives at both the Darden School of Business and the McIntire School of Commerce. Together, the cases provide the background for a scorable, bilateral, multi-issue negotiation in which there are congruent, distributive, and integrative issues. People and Congregations Engaged in Ministry (PACEM) was a nonprofit organization committed to helping homeless adults in the Charlottesville, Virginia, community find shelter during the cold months. Reliant upon volunteers, PACEM had partnered for the previous five years with Madison House, a nonprofit organization run by students at the University of Virginia that coordinated student volunteers, developed student leaders, and built community partnerships. In preparation for the return of Madison House volunteers to PACEM, Kennedy Brooks, PACEM's executive director and community partner, was going to meet with Riley Carter, Madison House's newly appointed program director, to develop and sign the Community Partner Agreement, which detailed the volunteer experience and logistics for the upcoming school year. Brooks and Carter also had to agree on training and communication procedures for the year, which had historically included mandatory training at Madison House and weekly site e-mail updates. All aspects of the volunteer experience were subject to change each year, and Carter had expressed an interest in making a few changes, but Brooks believed the current structure was ideal. How would the discussion go, and what would the outcomes be? Excerpt UVA-QA-0802 Rev. Jul. 30, 2014 PACEM: KENNEDY BROOKS Kennedy Brooks, executive director and community partner of People and Congregations Engaged in Ministry (PACEM), was looking forward to the return of Madison House volunteers. Brooks believed the current structure of the volunteer experience was ideal and was confident that the meeting with Riley Carter, the new program director from Madison House, would solidify that sentiment. Reflecting with a smile on the five-year partnership between Madison House and PACEM, Brooks prepared for a quick meeting with Carter by reviewing an e-mail Carter had sent the previous week (Exhibit 1). PACEM PACEM was a nonprofit organization committed to helping homeless adults in the Charlottesville, Virginia, community find shelter during the cold months (October through March). PACEM opened its doors in 2004 and had given or coordinated over 43,000 nights of shelter to homeless adults within the community. PACEM's mission was to engage the community of the greater Charlottesville area in providing shelter, compassionate support, and access to services for homeless people. . . .
Phonon dispersion evolution in uniaxially strained aluminum crystal

The influence of loading upon the phonon dispersion of crystalline materials could be highly nonlinear with certain particular trends that depend upon the loading path. In this paper, we have calculated the influence of [100] uniaxial strain on the phonon dispersion and group velocities in fcc aluminum using second moments of position obtained from molecular dynamics (MD) simulation at 300 K. In contrast to nonlinear monotonic variation of both longitudinal and transverse phonon frequencies along the $$\Delta $$ , $$\Lambda $$ and $$\Sigma $$ lines of the first Brillouin zone under tension, transverse phonon branches along the $$\Lambda $$ line show inflection at specific wavevectors when the compressive strain exceeds 5%. Further, the longitudinal group velocities along the high-symmetry $$\Delta $$ line vary non-monotonically with strain, reaching a minimum at 5% compressive strain. Throughout the strain range studied, the equilibrium positions of atoms displace in an affine manner preserving certain static structural symmetry. We attribute the anomalies in the phonon dispersion to the non-affine evolution of second moments of atomic position, and the associated plateauing of force constants under the applied strain path.
Decoupling the Effects of the Matrix Properties and Foam Structure on the Mechanical Properties of Microcellular Foam by Sub-Tg Annealing:

Sub-T g annealing microcellular polycarbonate for 100 hours at 135°C increases yield strength but decreases fatigue life and ductility. Annealing reverses the effect of CO 2 saturation-cycling on the mechanical properties of the foam matrix by decreasing the free volume created by the saturation-cycle. Consequently, annealing decouples the effects of the matrix properties and the microstructure on the mechanical behavior of microcellular foam.
Immunologic Assay of Biologically Active Materials

Publisher Summary This chapter presents details of the workshop focusing on immunologic assay of biologically active materials. The application of the macrophage migration test to the detection of bacterial mucopeptides from group A and B streptococci was presented. Such mucopeptides inhibit the migration of peritoneal macrophages from normal and germ-free rats which were deliberately not exposed to the antigen. A novel immunoassay using an enzyme-lableed antigen was presented. Blocking of this readily measureable activity by antibody in a solid phase system and the inhibition of this blocking by added free antigen was shown in a model system. This new and general method warrants further study and application to assays in biological fluids. The stability of the reagent, alkaline phosphatase coupled to antigen by gluturaldehyde was impressive. The method was extended to peroxidase and coupled to antigen by a diflourosulfone reagent. The ability of immunoassay to measure biologically active compounds and their inactive derivatives and precursors was stressed as both strength and weakness.
Molecular abnormalities of a phosphoglycerate kinase variant generated by spontaneous mutation

A new case of X chromosome-linked phosphoglycerate kinase (PGK) abnormality is described. The male proband was mentally retarded, had behavior disorders, and displayed episodes of hemolytic anemia. The enzyme activity of red blood cells from the patient was about 10% of normal, and that of the cultured fibroblasts was about 50% of normal cells. The variant PGK was characterized by a lower affinity for the substrates, reduced thermostability, and increased anodal electrophoretic mobility. The pH activity profile of the variant enzyme was different from that of normal. The amount of messenger RNA (mRNA) in the variant fibroblasts was comparable to that of normal fibroblasts. The mRNA coding for PGK was subjected to coupled reverse transcription followed by amplification by the polymerase chain reaction. Nucleotide sequence of the variant cDNA showed a point mutation, T/A\---|-C/G transition, in exon 9 of the variant gene. No other mutation was found in all coding regions of the variant. The mutation should cause Cys\---|-Arg substitution at the 315th position from the NH2-terminal Ser of PGK, and it created an additional Ava II (or isoschimatic) cleavage site in the variant gene. Because the variant gene was not detected in the proband's mother and siblings, it must have been generated by spontaneous mutation during oogenesis.
Magnetic cross-talk simulation between Q2 and L-bend magnets of APS-U

Abstract The Advanced Photon Source Upgrade project (APS-U) will replace the present storage ring of the Advanced Photon Source (APS) with a new storage ring based on a multi-bend achromat (MBA) lattice. Due to the increased number of magnets in each sector of the MBA lattice, the space between magnets is very limited, with the smallest separation between magnets being only 5 cm between the Q2 quadrupole in the doublet section and the adjacent M1 longitudinal gradient dipole (L-bend). Cross-talk between these magnets is of concern and is investigated in this work. Both magnets are modeled separately in Opera-3D, and then together as per their design layout in the MBA lattice. The trajectory of a 6.0 GeV electron beam through both magnets is calculated, the local field multipoles along that trajectory computed, and the integrated harmonics compared with a superposition of the fields in the individual magnets. These simulations show that the integrated quadrupole field of the Q2 magnet drops by 0.16% due to the presence of the M1, while the integrated dipole field of the M1 is practically unaffected. The effect on the higher-order multipoles at a radius of 10 mm was less than 0.01% of the integrated dipole field, and is within acceptable limits. The detailed magnetic structures of the Q2 and the M1, electron beam trajectory through these magnets, the local main and harmonic fields along the trajectory, and their integrals with and without cross-talk are reported.
The perceptions and experiences of national regulatory nurse leaders in advancing the advanced practice registered nurse compact policy agenda.

Background and purpose The Advanced Practice Registered Nurse (APRN) Compact was approved at the National Council of State Boards of Nursing Delegate Assembly in May 2015. Since that date, only three states have been successful in the legislative adoption of the compact. Thus, the purpose of this study was to explore the experiences and perceptions of nursing regulatory leaders involved with the individual state adoption of the APRN Compact. Methods This qualitative study followed a phenomenological-hermeneutic methodology approach. Conclusions Four themes emerged from within the data: legislative political environment; professional organizational barriers; strategies to push past barriers; and moving forward. An overarching theme of consistent communication was evident. Implications for practice This study identifies barriers experienced in the legislative state adoption process and successful strategies to overcome these barriers to move the APRN compact forward.
Broadband and Gate-Tunable Conducting Oxide Epsilon-Near-Zero Perfect Absorber

We demonstrate broadband and gate-tunable conducting oxide epsilon-near-zero perfect absorbers grown by atomic layer deposition. Absorption bandwidth (> 90%) of 214 nm for Berreman mode in NIR region is realized.