cssi/SciSciGPT-SciSciNet huggingface dataset:
Investigation and Analysis on Knowledge,Attitude and Practice about Occupational Health among Migrant Workers in Beijing City

[Objective]To investigate and analyze the knowledge attitude and practive about occupational health among migrant workers in Beijing City,and provide basic data and prevention advice for reducing and preventing occupational diseases,smoothly and effectively implement interventions,promoting health of professional population. [Methods]The face to face questionnaire survey was applied.Migrant workers filled the questionnaire independently and fully.Results were collected and analyzed by EpiData3.0 and SPSS 11.5 statistical software. [Results]Of 457 valid questionnaires,the accuracy rates of" Law of the People's Republic of Chinaon Prevention and Control of Occupational Disease",occupational health knowledge,attitude and behavior was 79.3%,74.4%,82.3% and 65.4% respectively.There was unbalancedness between high correct rate of attitude and low correct rate of behavior. [Conclusion]Long-term vocational training of occupational health knowledge should be implemented regularly.Occupational health education should be conducted to different workers at different level and should be combined with general health education.Therefore,migrant workers will do their best to cooperate with government,enterprise and sanitary department in occupational health surveillance.
Embedding Probabilities in Predication Space with Hermitian Holographic Reduced Representations

Predication-based Semantic Indexing (PSI) is an approach to generating high-dimensional vector representations of concept-relation-concept triplets. In this paper, we develop a variant of PSI that accommodates estimation of the probability of encountering a particular (such as \(\mathrm {fluoxetine}\ \) TREATS \(\mathrm {major\_depressive\_disorder}\)) in a collection of predications concerning a concept of interest (such as major depressive disorder). PSI leverages reversible vector transformations provided by representational approaches known as Vector Symbolic Architectures (VSA). To embed probabilities we develop a novel VSA variant, Hermitian Holographic Reduced Representations, with improvements in predictive modeling experiments. The probabilistic interpretation this facilitates reveals previously unrecognized connections between PSI and quantum theory - perhaps most notably that PSI’s estimation of relatedness across multiple reasoning pathways corresponds to the estimation of the probability of traversing indistinguishable pathways in accordance with the rules of quantum probability.
Efficient electro/photocatalytic water reduction using a [NiII(N2Py3)]2+ complex

The pyridine-rich complex [NiII(LN2Py3)(MeCN)](ClO4)2 (1) acts as an efficient electro- and photocatalyst in the generation of H2 from water. Observed TONs reach 1050 for electrocatalysis and a remarkable 3500 for photocatalysis. Experimental and DFT data support the ligand-reduced [NiIL˙] as the catalytically active species, contrasting with the [CoIL] observed for cobalt catalysts.
Video on Diet Before Outpatient Colonoscopy Does Not Improve Quality of Bowel Preparation: A Prospective, Randomized, Controlled Trial

Video on Diet Before Outpatient Colonoscopy Does Not Improve Quality of Bowel Preparation: A Prospective, Randomized, Controlled Trial
Hematopoeitic stem cell transplantation for adult T cell leukemia-lymphoma: Who is the best candidate?

Adult T cell leukemia/lymphoma (ATL) is a rare and highly aggressive peripheral T-cell neoplasm caused by human T-cell lymphotropic virus type-I (HTLV-1), a retrovirus endemic in Japan, sub-Saharan...
Coexistence of iAMP21 and ETV6-RUNX1 fusion in an adolescent with B cell acute lymphoblastic leukemia: literature review of six additional cases.

Intrachromosomal amplification of chromosome 21 (iAMP21) results from breakage-fusion-bridge cycles and chromothripsis is a distinct marker of a subgroup of B cell acute lymphoblastic leukemia (B-ALL) cases associated with a poor prognosis. iAMP21 accounts for 2% of pediatric B-ALL and occurs predominantly in older children or adolescents. ETV6-RUNX1 fusion, resulting from t(12;21)(p13;q22), is associated with an excellent outcome in younger children with B-ALL. Coexistence of iAMP21 with ETV6-RUNX1 fusion is extremely rare with limited clinical information available. We report the case of an 18-year old Caucasian man diagnosed with ETV6-RUNX1 fusion positive B-ALL. He was treated with intensive chemotherapy and achieved remission for 6 months before relapse, 15 months after the initial diagnosis. G-band karyotyping and Fluorescence in situ hybridization (FISH) analyses performed on bone marrow revealed complex abnormalities: 41,X,-Y,der(3)t(3;20)(p11.2;q11.2),-4,t(5;22)(q32;q11.2),del(9)(p13),dic(9;17)(p13;p11.2),t(12;21)(p13;q22),der(14)t(14;17)(p11.2;q11.2),der(17;22)(q11.2;q11.2),-20,add(21)(q22),-22[4]/46,XY[15] with an iAMP21 and an ETV6-RUNX1. Additional molecular studies confirmed ETV6-RUNX1 fusion and with a TP53 mutation. High-resolution single nucleotide polymorphism microarray (SNP array) revealed the iAMP21 to be chromothripsis of 21q and subsequent metaphase FISH further delineated complex genomic aberrations. Although the patient received intensive chemotherapy with allogenic stem cell transplant, he died 26 months after initial diagnosis. We searched the literature and identified six cases showing coexisting iAMP21 and ETV6-RUNX1. The median age for these six patients was 10 years (range, 2–18) and males predominated. The median overall survival (OS) was 28 months. Patients with B-ALL associated with both iAMP21 and ETV6-RUNX1 tend to be older children or adolescents and have a poor prognosis.
RE-p-halobenzoic acid–terpyridine complexes, part III: structural and supramolecular trends in a series of p-iodobenzoic acid rare-earth hybrid materials

A series of twenty-one new rare-earth p-iodobenzoic acid complexes, [RE(L1)3(L2)(H2O)]2 (RE = La3+ (1) Ce3+ (2)), [RE(L1)3(L2)]2·H2O (RE = Ce3+ (2′), Pr3+ (3), Nd3+ (4), Sm3+ (5)), Eu3+ (6), Gd3+ (7), Tb3+ (8), Dy3+ (9), Ho3+ (10), Er3+ (11), Tm3+ (12), Yb3+ (13), Lu3+ (14), Y3+ (15)), [RE(L1)3(L2)(H2O)]2 (RE = Yb3+ (13′), Lu3+ (14′), Y3+ (15′)), and RE2(L1)4(L2)2(Ox) (RE = Er3+ (11′), Tm3+ (12′)); L1: p-iodobenzoic acid; L2: 2,2′:6′,2′′-terpyridine; Ox: oxalic acid, have been hydrothermally synthesized and structurally characterized by single crystal and powder X-ray diffraction. The series includes binuclear complexes [(La3+–Ce3+), (Ce3+–Y3+)], mononuclear complexes (Yb3+–Y3+), and oxalate-bridged binuclear complexes (Er3+–Tm3+), formed as a result of in situ ligand synthesis. All twenty-one complexes feature halogen- and π-based supramolecular interactions which assemble the molecular complexes into one, two, and three dimensions. Solid-state visible and near-IR luminescence spectra were collected on complexes 5, 6, 8, 9, 12, and 13 and characteristic emission was observed. The local coordination geometry over the p-iodobenzoic acid series were analyzed and then compared to the previously described and characterized RE-p-chlorobenzoic acid and RE-p-bromobenzoic acid analogues. Additionally, structural trends and supramolecular motifs were extracted from this series of materials and compared with the previously reported p-chloro- and p-bromo materials.
Three Sets of Case Studies Suggest Logic and Consistency Challenges with Value Frameworks

Abstract Objective To assess the logic and consistency of three prominent value frameworks. Methods We reviewed the value frameworks from three organizations: the Memorial Sloan Kettering Cancer Center (DrugAbacus), the American Society of Clinical Oncologists, and the Institute for Clinical and Economic Review. For each framework, we developed case studies to explore the degree to which the frameworks have face validity in the sense that they are consistent with four important principles: value should be proportional to a therapy's benefit; components of value should matter to framework users (patients and payers); attribute weights should reflect user preferences; and value estimates used to inform therapy prices should reflect per-person benefit. Results All three frameworks can aid decision making by elucidating factors not explicitly addressed by conventional evaluation techniques (in particular, cost-effectiveness analyses). Our case studies identified four challenges: 1) value is not always proportional to benefit; 2) value reflects factors that may not be relevant to framework users (patients or payers); 3) attribute weights do not necessarily reflect user preferences or relate to value in ways that are transparent; and 4) value does not reflect per-person benefit. Conclusions Although the value frameworks we reviewed capture value in a way that is important to various audiences, they are not always logical or consistent. Because these frameworks may have a growing influence on therapy access, it is imperative that analytic challenges be further explored.
COMPARATIVE STUDY ON CATHETER-DIRECTED THROMBOLYSIS – CONTINUOUS TISSUE PLASMINOGEN ACTIVATOR VERSUS ANGIOJET CATHETER POWER PULSE SPRAY RHEOLYTIC THROMBECTOMY OUTCOME STUDY: SINGLE-CENTER EXPERIENCE

Background: Acute arterial occlusion of native and graft vessels has a variety of treatment options, including catheter-directed thrombolysis (CDT), power pulse spray with rheolytic thrombectomy (PPSRT) and surgery. We studied acute limb ischemia (ALI) outcomes with CDT vs PPSRT with adjunctive CDT
The Beliefs About Race Scale (BARS): Dimensions of racial essentialism and their psychometric properties.

OBJECTIVES Recent studies have found that racial essentialism negatively affects intergroup behavior (e.g., willingness to relate across outgroups), however this line of inquiry has been limited by 1-dimensional measures of racial essentialism. This paper provides psychometric support for the Beliefs About Race Scale (BARS), a multidimensional measure of racial essentialism. METHOD Participants included 492 adults recruited on a college campus and in the community. BARS items were developed by the researcher and were subjected to exploratory and confirmatory factor analyses, and reliability and validity analyses. Hierarchical regressions examined the relation of BARS subscales to outgroup discomfort. RESULTS Analyses supported a 4-factor model of racial essentialism, with good internal and test-retest reliability and construct validity. Two BARS subscales predicted outgroup discomfort above and beyond the effects of previous measures of racial and psychological essentialism. CONCLUSION Greater specification of racial essentialism offered by the BARS subscales should aid researchers in furthering our understanding of how racial essentialism affects intergroup behavior and the role of education in challenging people's essentialist beliefs about race. (PsycINFO Database Record
Synthesis, characterization, and photoluminescence of Er2O3–Er2SO2 nanoparticles on reduced graphene oxide

Thermal reduction of erbium nitrate and S-doped reduced graphene oxide (rGO) mixture resulted in the formation of small (∼3-18 nm sized) Er2O3-Er2SO2 nanoparticles with a high degree of surface coverage on the reduced GO support. The morphology, structure, and the chemical composition of the synthesized nanoparticles have been studied by scanning and transmission electron microscopy, x-ray photoelectron spectroscopy, x-ray diffraction, and by optical spectroscopies. The rGO-supported Er2O3-Er2SO2 nanoparticles (Er2O3-Er2SO2/rGO) demonstrate sufficiently strong light emission (luminescence and upconversion) in the visible and near-infrared range via intra-4f Er3+ optical transitions. The reported synthetic approach demonstrates a novel method for synthesizing Er-containing nanoparticles for sensor applications.
A Text of Identity: Frances Brooke and the Rhetoric of the Aging Spinster

Frances Brooke, writing in 1755 in London, England, selected the figure of the aging spinster as her alter ego when she wrote and edited a thirty-seven issue periodical, The Old Maid. Analysis of the periodical and the cultural environment in which Brooke wrote explains her choice of persona in terms of the issues she faced as a woman producing writing to be read largely by male contemporaries. This analysis reveals some of the underlying stereotypes of aging and identity in the period as well as the way these stereotypes could be used by a clever writer.
The general error correction model in practice

Enns et al. respond to recent work by Grant and Lebo and Lebo and Grant that raises a number of concerns with political scientists’ use of the general error correction model (GECM). While agreeing ...
Exploring deep-water coral communities using environmental DNA

Abstract Environmental DNA (eDNA) sequencing has emerged as a valuable tool for biodiversity surveys, allowing identification of taxa that may be missed by more traditional methods. Deep-sea corals, while increasingly recognized as a valuable source of habitat in the deep-ocean, have traditionally been challenging to survey. Obstacles to traditional visual surveys of these animals include the expense and complexity inherent to working in the deep marine environment, as well as the existing taxonomic uncertainty and morphological variation which can make deep-sea octocorals difficult to identify visually to the species level. This study tests an eDNA protocol for identification of deep-sea octocorals from water samples collected during the E/V Nautilus 2016 cruise season. Using this protocol, we were able to sequence eDNA from octocorals, and use these data along with image data collected during the cruise to identify taxa to the species level in a variety of habitats. eDNA sampling has the potential to complement traditional deep-sea coral surveys by overcoming the difficulty in visually identifying deep-sea octocorals and characterizing their diversity.
Oncolytic Viruses-Natural and Genetically Engineered Cancer Immunotherapies.

There has long been interest in innovating an approach by which tumor cells can be selectively and specifically targeted and destroyed. The discovery of viruses that lyse tumor cells, termed oncolytic viruses (OVs), has led to a revolution in the treatment of cancer. The potential of OVs to improve the therapeutic ratio is derived from their ability to preferentially infect and replicate in cancer cells while avoiding destruction of normal cells surrounding the tumor. Two main mechanisms exist through which these viruses are reported to improve outcomes: direct lysis of tumor cells and indirect augmentation of host anti-tumor immunity. With these factors in mind, viruses are chosen or modified to selectively target tumor cells, decrease pathogenicity to normal cells, decrease the anti-viral immune response (to prevent viral clearance), and increase the anti-tumor immune response. While only one OV has been approved for the treatment of cancer in the US and only two other OVs have been approved worldwide, a wide spectrum of OVs are in various stages of pre-clinical development and in clinical trials. These viruses are being studied as alternatives and adjuncts to more traditional cancer therapies including surgical resection, chemotherapy, radiation, hormonal therapies, targeted therapies, and other immunotherapies. Here, we review the natural characteristics and genetically engineered modifications that enhance the effectiveness of OVs for the treatment of cancer.
Cis-acting DNA elements flanking the variable major protein expression site of Borrelia hermsii are required for murine persistence.

In Borrelia hermsii, antigenic variation occurs as a result of a nonreciprocal gene conversion event that places one of ~60 silent variable major protein genes downstream of a single, transcriptionally active promoter. The upstream homology sequence (UHS) and downstream homology sequence (DHS) are two putative cis-acting DNA elements that have been predicted to serve as crossover points for homologous recombination. In this report, a targeted deletion/in cis complementation technique was used to directly evaluate the role for these elements in antigenic switching. The results demonstrate that deletion of the expression site results in an inability of the pathogen to relapse in immunocompetent mice, and that the utilized technique was successful in producing complemented mutants that are capable of antigenic switching. Additional complemented clones with mutations in the UHS and DHS of the expressed locus were then generated and evaluated for their ability to relapse in immunocompetent mice. Mutation of the UHS and inverted repeat sequence within the DHS rendered these mutants incapable of relapsing. Overall, the results establish the requirement of the inverted repeat of the DHS for antigenic switching, and support the importance of the UHS for B. hermsii persistence in the mammalian host.
Gametophytic Gene Expression

Gametophytic gene expression is a topic of both basic and applied interest. It has been subjected to many reviews, starting with Buchholz (1922) and continuing with unabated interest to the present (Zamir, 1983; Mulcahy, 1984). Consequently, this review will focus on general characteristics and principles.
Non-staple Endoscopic Management of Zenker Diverticulum

With the introduction of modern equipment, imaging, and surgical techniques, many surgeons now treat Zenker diverticula via endoscopic approaches. Newer equipment and imaging systems have allowed adequate exposure of the esophagodiverticular wall which contains the cricopharyngeal muscle enabling its division by various means. This chapter addresses these methods, including laser-assisted diverticulotomy, stapler-assisted diverticulotomy, harmonic scalpel-assisted diverticulotomy, and bipolar diathermic electrocoagulation division of the party wall. Perioperative treatment is directed at avoiding mediastinitis in all of the endoscopic approaches. Treatment outcomes for endoscopic approaches to Zenker diverticula have consistently been excellent with first-treatment success and low complication rates. Zenker diverticula can be safely and effectively managed with endoscopic techniques for the majority of patients. Large Zenker diverticula should be treated with stapler-assisted technique. Treatment of smaller Zenker diverticula or difficult-to-expose diverticula should be attempted with laser-assisted diverticulotomy.
A Novel RMND1 knock-in Mouse Recapitulates Clinical and Biochemical Abnormalities Observed in Patients (P3.329)

Objective: To elucidate the function of RMND1 in mitochondrial protein translation and characterize the effects of RMND1 mutations in vivo by generating and characterizing RMND1- mutant mice harboring the common N239S RMND1 mutation. Background: RMND1 belongs to the sif2 family of proteins that share the domain of unknown function DUF155. Although RMND1 function is unknown, it localizes to the inner mitochondrial membrane and it is involved in mitochondrial translation, probably in the assembly and maintenance of the mitoribosome. Patients with RMND1 mutations (~30 reported so far) present with a wide range of symptoms; congenital sensorineural deafness, hypotonia, developmental delay and lactic acidaemia are common clinical manifestations with life expectancy at birth under 2 years. A less severe phenotype with onset after 4 years, includes renal involvement and milder neurological phenotype. Patient muscle and/or fibroblasts show severe combined defects of the mitochondrial respiratory activities, particularly Complex I and IV, associated with impairment of mitochondrial protein synthesis. Currently, no in vivo models of RMND1 dysfunction exist. Design/Methods: We assessed lifespan, growth, motor skills and mitochondrial function from muscle, kidney, and brain of ~1 month-old Rmnd1 k.i. mice. Results: Homozygous RMND1 knock-in mice show failure to thrive, muscle weakness, impaired motor function, and died within the first two months of life. Biochemical analysis of mitochondrial respiratory chain enzymes (RCE) activities in muscle and kidney showed complex IV (COX) deficiency. In muscle, activity of citrate synthase (CS), an index of mitochondrial mass, was significantly increased, probably as a result of a compensatory mechanism. Conclusions: This murine model partially recapitulates clinical and biochemical features of the human disease. The generation and characterization of an in vivo model of RMND1 dysfunction is a critical first step towards an understanding of RMND1 function in mitochondrial translation and will be important to elucidate the pathomechanism of RMND1-dependent mitochondrial disease, and develop therapeutic approaches. Study Supported by: MDA295105 (Quinzii) Disclosure: Dr. SANCHEZ-QUINTERO has nothing to disclose. Dr. Lopez Gomez has nothing to disclose. Dr. Quinzii Hirano has nothing to disclose.
Using Facebook to communicate mammography messages to rural audiences.

OBJECTIVE The purpose of this scholarly project was to answer the following question: What is the highest level of engagement achieved with a mammography campaign on Facebook? DESIGN AND SAMPLE An Idaho public health department implemented a tailored message mammography campaign on Facebook during Breast Cancer Awareness Month. Target sample for the Facebook campaign were women and men over the age of 40 in rural Idaho. MEASURES Data collected from Facebook were used to measure and stratify engagement into a hierarchy of six levels, with intent to get a mammogram representing the highest level of engagement. A survey measuring women's intent to a get a mammogram was distributed via an online link. RESULTS The posts reached 48,503 Facebook users-11,147 of the total reach were unique users. Intent to get a mammogram, the highest level of engagement, was stated both in Facebook comments and on the online survey. Forty-nine women completed the survey, and 82% of women expressed intent to get a mammogram in the next year. CONCLUSION This project conducted as a program evaluation demonstrates how public health nurses can develop, implement, and evaluate Facebook mammography campaigns in the future.
Literature and Cartography: Theories, Histories, Genres, edited by Anders Engberg-Pedersen

An outgrowth of scholarship in the cartographic approach to literary studies, this collection of essays defines a discourse that stretches back to Viktor Shklovsky’s 1917 theory of estrangement as ...
Comparison of the NHANES dietary screener questionnaire to the Automated Self-Administered 24-Hour Recall for Children in the Healthy Communities Study.

A dietary screener questionnaire (DSQ) was used to assess dietary outcomes among children in the Healthy Communities Study (HCS), a study of the relationships between programs and policies to prevent child obesity and child diet, physical activity and weight outcomes. To compare dietary intake estimates derived from the DSQ against those from the Automated Self-Administered 24-Hour Recalls for Children (ASA24-Kids) among children, a measurement error model, using structural equation modelling, was utilized to estimate slopes, deattenuated correlation coefficients, and attenuation factors by age and sex, ethnicity, and BMI status. A randomly selected sub-sample of HCS participants aged 4–15 years in 130 communities throughout the U.S. who completed the DSQ and up to two ASA24-Kids recalls (n = 656;13% of HCS participants). For most nutrient/foods examined, the DSQ yielded larger mean intake estimates than the ASA24-Kids, and agreement between the two measures varied by food/nutrient, age and sex, ethnicity, and BMI category. Deattenuated correlation coefficients of 0.4 or greater were observed for added sugars from SSBs (0.54), fruits and vegetables (0.40), and dairy foods (0.50). Lower deattenuated correlation coefficients were seen for total added sugars (0.37), whole grains (0.34), and fiber (0.34). Attenuation factors were most severe for total added sugars intake among overweight children, and for several other dietary outcomes among children aged 9–11 years. The DSQ was found to be a tool with acceptable agreement with the ASA24-Kids for measuring multiple dietary outcomes of interest in the HCS, although there may be potential due to measurement error to underestimate results (bias towards the null). In future studies, measurement error modelling and regression calibration may be possible solutions to correct for bias due to measurement error in most food/nutrient intake estimates from the DSQ when used among children.
Nutrient-induced Mitochondrial Activation (NiMA): A Novel Lysosome-to-Mitochondria Signaling Pathway Disrupted by Amyloid-β Oligomers

The mechanisms of mitochondrial dysfunction in Alzheimer’s Disease (AD) are incompletely understood. Using two-photon fluorescence lifetime microscopy of NAD(P)H and tracking brain oxygen metabolism with multi-parametric photoacoustic microscopy, we show that activation of lysosomal mechanistic target of rapamycin complex 1 (mTORC1) by insulin or amino acids stimulates mitochondrial activity and regulates mitochondrial DNA synthesis in neurons. Amyloid-β oligomers, which are precursors of amyloid plaques in AD brain and stimulate mTORC1 protein kinase activity at the plasma membrane, but not at lysosomes, block this nutrient-induced mitochondrial activity (NiMA) by a mechanism dependent on tau, which forms neurofibrillary tangles in AD brain. NiMA was also disrupted in fibroblasts derived from a patient with tuberous sclerosis complex, a genetic disorder that causes dysregulation of lysosomal mTORC1. Thus, lysosomal mTORC1 couples nutrient availability to mitochondrial activity, and links mitochondrial dysfunction to AD by a mechanism dependent on soluble building blocks of plaques and tangles.
Quality insights: artificial neural network and taxonomical analysis of activity networks in quality engineering

The resurgence and advancement of artificial intelligence (AI) has spurred new research interests in applying or re-applying proven techniques from the 1990s to challenges in business and industry. The area of quality engineering and technology is particularly amenable to the application of AI techniques. Quality engineering programs are predicted on recurring quality projects that are made up of specific activities. The proper management of such activities is a precursor for the success of any quality program. This research paper explores the application of the proven technique of artificial neural network to activity networking in the management of quality programs.
Altered baroreflex sensitivity in young women with a family history of hypertension

Having a family history of hypertension increases the risk of developing future hypertension. Reductions in baroreflex function have been demonstrated in hypertension and are an important marker fo...
Novel Trans-Septal Left Atrial VAD Cannulation Technique for Hypertrophic/Restrictive Cardiomyopathy

Purpose Left ventricular assist device (LVAD) outcomes for hypertrophic (HCM) or restrictive cardiomyopathy (RCM) with a small LV are unsatisfactory due to difficulty draining via an LV apical cannula. We developed a new transeptal cannulation technique to decompress the left atrium where the atrial septum is cannulated via the right atrium. Methods Retrospective review of our institutional experience with LVAD/BiVAD implantation in HCM or RCM patients from October 2016 to Aug 2018. Outcomes following implantation were analyzed, including subsequent interventions, quality of VAD output, and patient outcomes. Results In total, 5 patients underwent LVAD implantation with trans-septal left-atrial cannulation techniques (HCM = 4 patients, RCM =1). Two patients received Berlin Heart BiVADs, 1 received a Berlin Heart LVAD, 1 patient received PediMag BiVADs, and 1 patient received a Heartware LVAD. Total support days were 485 days. Three patients underwent successful heart transplant after 275, 111 and 62 days of support. One neonate with HCM died from sepsis 27 days after PediMag BiVAD placement. One RCM patient died 10 days after Berlin Heart BiVAD placement following extracorporeal membrane oxygenation due to ARDS. Total survival rate is 60%. All three survivors did not develop any neurological deficits or complications related to thrombus and were discharged home after heart transplant. Conclusion This novel trans-septal left-atrial LVAD cannulation strategy is a viable alternative cannulation technique for HCM or RCM patients with a small left ventricular cavity. This technique can be applied to a variety of pediatric and adult devices in children ranging from infants to adults.
Education for a Post-Work Future: Automation, Precarity, and Stagnation

This paper considers how mainstream economic conceptions of education and employment are losing coherence as technological displacement of labor tracks with global economic stagnation and inequality. The paper engages in what Daniel Bell once referred to as ‘social forecasting’ to suggest that if automation and precaritization of employment continue as some predict, this will likely intensify pressure on educational systems to perform for the economy and thus deepen social conflicts over educational access, knowledge production, class, and racial stratification. At the same time, the paper argues that narrow human capital models reduce the capacity of formal education to creatively meet the expansive challenges immanent to a potential post-work landscape by circumscribing the innovative potential of education, knowledge, and subjectivity. In conclusion, the article discusses mainstream economic, post-Keynesian, and emergent radical-progressive perspectives on post-work alternatives for education and society.
The Liminal Researcher: Being Not Quite the Center of Attention

Liminality refers to being “betwixt and between” (Turner, 1967). We draw on boundary theory to propose and elaborate upon the notion of “liminal researchers”—the in-between status we hold when we c...
‘Free’-Market ‘Knowledge’: Seven Suggested Research Topics

This chapter highlights a number of issues that require further investigation. What, for example, is the numerator and the denominator of the Austrian tax dependency ratio (X/Y), where X is the millions (or billions?) of dollars that Austrians have appropriated, and Y is their ‘research’ output? It would be useful to have a metrics-based examination of what type of producer-sovereignty students of Austrian economics have been exposed to; what ‘free’ market donors believe they are funding; plus a systematic study of Mises’ influence over the anti-democratic spectrum—including those who funded Hitler. Most if not all of those ‘scholars’ who promote the ‘free’ market are on the payroll of the Tobacco, Obesity and Fossil Fuel industries. It would be useful to examine the cluster of behavioural characteristics of those who put ‘financial considerations’ ahead of their ‘professional’ reputation. What would be revealed by a Mises-inspired examination of ‘life history by the psycho-analytical method’ (or any other method) of those who assert that ‘Waking and dreaming man’s wishes turn upon sex’?
Intraoperative liposomal bupivacaine for skin graft donor site analgesia: A retrospective cohort study

Abstract Introduction Burn injury and reconstructive operations often result in severe pain, particularly at skin graft donor sites. Traditional local anesthetics administered intraoperatively control pain at donor sites, but the duration of action is short. Liposomal bupivacaine, a novel local anesthetic, can provide sustained-release analgesia for 72 h. The primary aim of this study was to describe the efficacy of liposomal bupivacaine for postoperative donor site pain control for patients undergoing skin graft procedures. Methods A retrospective cohort study was performed on patients who received a donor site liposomal bupivacaine field block and was compared to a matched control. Patients rated donor site pain on post-operative day 0 and 1, and stated whether the donor or graft site was more painful. Results Fifty-eight patients were included. Twenty-nine patients received liposomal bupivacaine. Eighty-six percent of patients in the treatment group rated donor site pain as three or less on postoperative day 0 and 1, compared to 3.4% in the control (p Conclusion Patients who received liposomal bupivacaine reported less postoperative donor site pain and found the donor site to be less bothersome without major complications. Liposomal bupivacaine may be a safe and promising agent for prolonging postoperative analgesia and minimizing donor site pain.
Molecular profiling and analysis of genetic aberrations aimed at identifying potential therapeutic targets in fibrolamellar carcinoma of the liver

Background Fibrolamellar carcinoma (FLC) is a rare primary liver cancer of young adults. A functional chimeric transcript resulting from the in-frame fusion of the DNAJ homolog, subfamily B, member 1 (DNAJB1), and the catalytic subunit of protein kinase A (PRKACA) genes on chromosome 19 is believed to be unique in FLC, with a possible role in pathogenesis, yet with no established therapeutic value. The objective of the current study was to understand the molecular landscape of FLC and to identify potential novel therapeutic targets. Methods Archival fresh, formalin-fixed, paraffin-embedded samples from patients with FLC who prospectively consented to an institutional review board-approved protocol were analyzed using Memorial Sloan Kettering-Integrated Mutation Profiling of Actionable Cancer Targets (MSK-IMPACT), a next-generation sequencing assay encompassing up to 468 key cancer genes. Custom targeted RNA-Seq was performed in selected patients. Demographics, treatment, and outcome data were collected prospectively. Survival outcomes were estimated and correlated with mutation and/or copy number alterations. Results A total of 33 tumor samples from 31 patients with FLC were analyzed. The median age of the patients at the time of diagnosis was 18 years and approximately 53% were women. The DNAJB1-PRKACA fusion transcript was detected in 100% of patients. In 10 of 31 patients in which MSK-IMPACT did not detect the fusion, its presence was confirmed by targeted RNA-Seq. TERT promoter mutation was the second most common, and was detected in 7 patients. The median follow up was 30 months (range, 6-153 months). The 3-year overall survival rate was 84% (95% CI, 61%-93%). Conclusions The DNAJB1-PRKACA fusion transcript is nonspecific and nonsensitive to FLC. Its potential therapeutic value currently is under evaluation. Opportunities currently are under development for therapy that may be driven or related to the DNAJB1-PRKACA fusion transcript or any therapeutic target identified from next-generation sequencing in patients with FLC.
A Probabilistic, Non-parametric Framework for Inter-modality Label Fusion

Multi-atlas techniques are commonplace in medical image segmentation due to their high performance and ease of implementation. Locally weighting the contributions from the different atlases in the label fusion process can improve the quality of the segmentation. However, how to define these weights in a principled way in inter-modality scenarios remains an open problem. Here we propose a label fusion scheme that does not require voxel intensity consistency between the atlases and the target image to segment. The method is based on a generative model of image data in which each intensity in the atlases has an associated conditional distribution of corresponding intensities in the target. The segmentation is computed using variational expectation maximization (VEM) in a Bayesian framework. The method was evaluated with a dataset of eight proton density weighted brain MRI scans with nine labeled structures of interest. The results show that the algorithm outperforms majority voting and a recently published inter-modality label fusion algorithm.
A Nested Simulation Optimization Approach for Portfolio Selection

We consider the problem of portfolio selection with risk factors, where the goal is to select the portfolio position that minimizes the value at risk (VaR) of the expected portfolio loss. The problem is computationally challenging due to the nested structure caused by the risk measure VaR of the conditional expectation, along with the optimization over a discrete and finite solution space. We develop a nested simulation optimization approach to solve this problem. In the outer layer, we adapt the optimal computing budget allocation (OCBA) approach to sequentially allocate the simulation budget of the outer-layer to different portfolio positions. In the inner layer, we propose a new sequential procedure to efficiently estimate the VaR of the expected loss. We present a numerical example that shows that our approach achieves a higher probability of correct selection under the same computing budget compared to three other methods.
Shape Stability of Truncated Octahedral fcc Metal Nanocrystals

Metallic nanocrystals (NCs) can be synthesized with tailored nonequilibrium shapes to enhance desired properties, e.g., octahedral fcc metal NCs optimize catalytic activity associated with {111} facets. However, maintenance of optimized properties requires stability against thermal reshaping. Thus, we analyze the reshaping of truncated fcc metal octahedra mediated by surface diffusion using a stochastic atomistic-level model with energetic input parameters for Pd. The model describes NC thermodynamics by an effective nearest-neighbor interaction and includes a realistic treatment of diffusive hopping for undercoordinated surface atoms. Kinetic Monte Carlo simulation reveals that the effective barrier, Eeff, for the initial stage of reshaping is strongly tied to the degree of truncation of the vertices in the synthesized initial octahedral shapes. This feature is elucidated via exact analytic determination of the energy variation along the optimal reshaping pathway at low-temperature (T), which involves transfer of atoms from truncated {100} vertex facets to form new layers on {111} side facets. Deviations from predictions of the low-T analysis due to entropic effects are more prominent for higher T and larger NC sizes.
A conceptual framework of teacher turnover: a systematic review of the empirical international literature and insights from the employee turnover literature

We present a conceptual framework of teacher turnover, which is guided by the broader employee turnover literature and supported by the empirical literature. Synthesising nearly forty years of inte...
Exposure of zebrafish larvae to water accommodated fractions of weathered crude oil alters steroid hormone concentrations with minimal effect on cholesterol

Abstract Crude oil has multiple toxic effects in fish, particularly early life stages. Recent transcriptomics studies have highlighted a potential effect on cholesterol homeostasis and biosynthesis, but have not investigated effects on steroid hormones, which are biosynthetically downstream metabolites of cholesterol. We exposed zebrafish (Danio rerio) embryos and larvae to 3 concentrations of a high energy water accommodated fraction (HEWAF) of crude oil and measured effects on cholesterol and steroid hormones at 48 and 96 hours post fertilization (hpf). HEWAF exposure caused a small decrease in cholesterol at 96 hpf but not 48 hpf. HEWAF-exposed larvae had higher levels of androstenedione, testosterone, estradiol, cortisol, corticosterone, and progesterone at 96 hpf compared to controls, while effects at 48 hpf were more modest or not present. 2-Methoxyestradiol was lower following HEWAF exposure at both time points. Dihydrotestosterone was elevated in one HEWAF concentration at 48 hpf only. Our results suggest that hormone imbalance may be an important toxic effect of oil HEWAF exposure despite no major effect on their biosynthetic precursor cholesterol.
Nuns and Nunneries in Renaissance Florence

The 15th century was a time of dramatic and decisive change for nuns and nunneries in Florence. In the course of that century, the city's convents evolved from small, semiautonomous communities to large civic institutions. By 1552, roughly one in eight Florentine women lived in a religious community. Historian Sharon T. Strocchia analyzes this stunning growth of female monasticism, revealing the important roles these women and institutions played in the social, economic, and political history of Renaissance Florence. It became common practice during this time for unmarried women in elite society to enter convents. This unprecedented concentration of highly educated and well-connected women transformed convents into sites of great patronage and social and political influence. As their economic influence also grew, convents found new ways of supporting themselves; they established schools, produced manuscripts, and manufactured textiles. Strocchia has mined previously untapped archival materials to uncover how convents shaped one of the principal cities of Renaissance Europe. She demonstrates the importance of nuns and nunneries to the booming Florentine textile industry and shows the contributions that ordinary nuns made to Florentine life in their roles as scribes, stewards, artisans, teachers, and community leaders. In doing so, Strocchia argues that the ideals and institutions that defined Florence were influenced in great part by the city's powerful female monastics. Nuns and Nunneries in Renaissance Florence shows for the first time how religious women effected broad historical change and helped write the grand narrative of medieval and Renaissance Europe. The book is a valuable text for students and scholars in early modern European history, religion, women's studies, and economic history.
Very-Large-Array Observations of Evolving Type I Noise Storms and Nonthermal Bursts In Association With Flares And Coronal Mass Ejections

Very-Large-Array (VLA) observations of the Sun at 20, 91 and 400 cm have been combined with data from the SOHO, TRACE and Wind solar missions to study the properties of long-lasting Type I noise storms and impulsive metric and decimetric bursts during solar flares and associated coronal mass ejections. These radio observations provide information about the acceleration and propagation of energetic electrons in the low and middle corona as well as their interactions with large-scale magnetic structures where energy release and transport takes place. For one flare and its associated CME, the VLA detected impulsive 20 and 91 cm bursts that were followed about ten minutes later by 400 cm burst emission that appeared to move outward into the corona. This event was also detected by the Waves experiment on Wind which showed intense, fast-drifting interplanetary Type III bursts following the metric and decimetric bursts detected by the VLA. For another event, impulsive 91 cm emission was detected about a few minutes prior to impulsive bursts at 20.7 cm, suggesting an inwardly propagating beam of electrons that excited burst emission at lower levels and shorter wavelengths. We also find evidence for significant changes in the intensity of Type I noise storms in the same or nearby active region during impulsive decimetric bursts and CMEs. These changes might be attributed to flare-initiated heating of the Type I radio source plasma by outwardly-propagating flare ejecta or to the disruption of ambient magnetic fields by the passage of a CME.
Concatenated low density parity check (LDPC) codes for magnetic recording channels

In this paper discussed for magnetic recording channels, a concatenated LDPC coding scheme which employs a column weight LDPC inner code and an outer LDPC code with large column weight to handle the residual errors.
Oxidation of Branched Chain Amino Acids by Isolated Hearts and Diaphragms of the Rat: THE EFFECT OF FATTY ACIDS, GLUCOSE, AND PYRUVATE RESPIRATION

Abstract Amino acid oxidation was studied in perfused hearts and incubated hemidiaphragms of rats fed ad libitum. Hearts were perfused with Krebs-Henseleit bicarbonate buffer containing glucose and 0.1 mm amino acids. The addition of 1 mm octanoate to the medium markedly stimulated 14CO2 production from [1-14C]leucine, isoleucine, and valine; inhibited 14CO2 production from [1-14C]alanine, pyruvate, and α-ketoglutarate, and did not affect 14CO2 production from [14C]histidine, threonine, glutamate, ornithine, and phenylalanine. Hemidiaphragms incubated with 1 mm hexanoate or 0.1 to 1.0 mm octanoate increased the oxidation of the branched chain amino acids by 80 to 200% and decreased 14CO2 production from alanine and pyruvate. Octanoate stimulated the oxidation of isoleucine by hemidiaphragms at isoleucine concentrations between 0.01 to 1.0 mm; when isoleucine exceeded 2 mm, octanoate became inhibitory. Octanoate stimulated the oxidation of the branched chain amino acids in the presence or absence of glucose and in the presence or absence of insulin from the medium, in diaphragms and hearts. Bovine serum albumin did not affect branched chain amino acid oxidation in the absence of added fatty acids; it inhibited the stimulatory effect of the latter. The inhibition was proportional to the albumin concentration. Palmitate and oleate (1 mm) added to albumin (15 mg per ml) stimulated branched chain amino acid oxidation by hemidiaphragms; the effect was smaller than that observed with equimolar octanoate and albumin. In hearts, no effect of 1 mm palmitate was observed. Butyrate (2 mm) did not affect branched chain amino acid oxidation by hemidiaphragms; 4 mm dl-β-OH butyrate and 4 mm acetate were inhibitory. In hearts and diaphragms, the omission of glucose from the incubation medium stimulated the oxidation of the branched chain amino acids. Pyruvate added to media containing glucose caused further inhibition of branched chain amino acid oxidation. Insulin stimulated 14CO2 production from [14C]leucine in hearts obtained from rats fasted for 48 hours and perfused without glucose. In hearts perfused with [14C]leucine, the addition of octanoate to the perfusate did not affect the tissue concentration of free leucine nor the labeling of the leucine pool. Octanoate stimulated 14CO2 production from leucine by hemidiaphragms which were preloaded with [14C]leucine, indicating stimulation of leucine oxidation beyond the transport of leucine into muscle cells. The apparent inverse relationship between the oxidation of pyruvate and that of the branched chain amino acids suggests that regulation of the latter may occur at the oxidative decarboxylation of the branched chain α-keto acids in muscles. It is suggested that regulation of branched chain amino acid catabolism in muscles may compliment the "alanine cycle," and may play a role in homeostasis under conditions of limited availability of glucose (e.g. fasting) or increased utilization (e.g. exercise).
Robust tracking/impedance control: Application to prosthetics

Stability and human-like motion are among the main factors that should be considered while designing a prosthetic limb. The prosthetic limb should be capable of accommodating environmental forces. The existence of parametric uncertainties has raised the need for robust stability and performance of the prosthesis. In this paper, a mixed tracking/impedance robust controller is developed based on passivity techniques. The controller is developed for general robotic manipulators and then applied to a powered knee/ankle prosthesis model attached to a robotic testing machine. Tracking control is used for the hip and thigh links of the test robot, while impedance control is used for the knee and ankle joints of the prosthesis. The dynamics resulting from the interaction between robot and environment are stabilized by specifying a suitable target impedance. The robust passivity framework was used to derive a joint space controller. A Lyapunov function is used to show that the tracking errors of the motion-controlled joints approach zero, while the impedance of the remaining joints approaches the designed target. A simulation study shows how impedance parameters can be used to trade off reference tracking of the impedance-controlled joints and interaction forces.