cssi/SciSciGPT-SciSciNet huggingface dataset:
Study on the treatment outcome and its related factors of children with congenital hypothyroidism

Objective To analyse the related factors of influence to children with congenital hypothyroidism(CH)after treatment outcome,and to provide the basis for judging treatment outcome. Methods By grouping comparison,in the statistical chi-square analysis,to retrospectively analyse and summarize the possible related factors of 424 cases of children with CH after standard treatment.To analyse the related factors of influence to children with CH after treatment outcome using Logistic multivariate regression analysis. Results There were statistically significant differences between the two groups of the abnormal thyroid after color Doppler ultrasound checked(suggest thyroid dysplasia)(P0.01),no significant differences was found among gender groups,the groups whether concurrent hypoxic-ischemic encephalopathy(HIE),the high blood bilirubin groups,and the groups of thyroid-stimulating hormone(TSH)outliers when confirmed,the differences between the corresponding two groups were not statistically significant(P0.05). Conclusion It is found that the treatment outcome for children with CH should be concerned with thyroid dysplasia at birth,and shouldn't be concerned with gender,HIE,high blood bilirubin at birth and the outliers of TSH when confirmed.Color Doppler ultrasound checked for thyroid at born can help to predict the outcome after treatment.
Fertility and Childbearing Among American Female Physicians

Abstract Background: Female physicians may experience unique challenges regarding fertility and family planning. We sought to determine childbearing patterns and decision-making among American female physicians. Materials and Methods: In 2012–2013, we surveyed a random sample of 600 female physicians who graduated medical school between 1995 and 2000. Primary outcome measures included fertility and childbearing history, reflections regarding decision-making, perceptions of workplace support, and estimations of childbearing potential. Results: Response rate was 54.5% (327/600). A majority (82.0%) of the sample were parents, 77.4% had biological children with an average of 2.3 children. Average age at medical school graduation was 27.5 years, at completion of training (completion of medical school, residency, and/or fellowship) was 31.6 years, and at first pregnancy was 30.4 years. Nearly one quarter (24.1%) of respondents who had attempted conception were diagnosed with infertility, with an average age at ...
The Potential for Advanced Limiter/Divertor Systems

The Advanced Limiter-divertor Plasrna-facing Systems (ALPS) program was initiated in FY 1998 in order to evaluate the potential for improved performance and lifetime for plasma-facing systems. The main goal of the program is; to demonstrate the advantages of advanced limiter/divertor systems over conventional systems in terms of power density capability, component lifetime, and power conversion efficiency, while providing for safe operation and minimizing impurity concerns for the plasma.
Visual entity linking

Entity linking is the task of identifying entities like people and places in textual data and linking them to corresponding entities in a knowledge base. In this paper we solve a visual equivalent of this task called visual entity linking. The goal is to link regions of images to corresponding entities in knowledge bases. Visual entity linking will enable computers to better understand visual content and thus can be used in tasks like image retrieval and visual question answering. More specifically, we propose a novel approach for linking image regions to entities in Dbpedia and Freebase. First, we select candidate entities using an automatic image description generation algorithm. We then extract image regions using object detection methods and compare them to depictions of entities in a knowledge base. We evaluate our approach on the Flickr8k dataset through surveys on Amazon Mechanical Turk, and present an extensive analysis to identify the sources of errors in our system.
Simultaneous Longitudinal Strain in All 4 Cardiac Chambers: A Novel Method for Comprehensive Functional Assessment of the Heart.

Background— Simultaneous assessment of longitudinal strain (LS) by 2D speckle-tracking echocardiography in all 4 cardiac chambers has not yet been explored. Our goal was to study LS curves obtained simultaneously from all 4 cardiac chambers in healthy subjects to gain insight into interchamber functional relationships. Methods and Results— We studied 259 healthy subjects (age 44±15; 118 men) in whom it was possible to obtain apical 4-chamber views that contained the entire left and right ventricles and both atria in the same sector. 2D speckle-tracking echocardiography was performed in all 4 chambers in the same cardiac cycle, while considering the interventricular septum as part of the left ventricle and including the interatrial septum in the LS measurements for both atria. LS was measured over time using vendor-independent software (Epsilon), resulting in peak LS and time-to-peak strain. Strain curves of the right ventricle and right atrium were larger in magnitude than those of the left ventricle and left atrium, whereas time-to-peak values were shorter. LS for the ventricles peaked earlier than the LS for the corresponding atria. Peak systolic LS values were larger in magnitude in women than in men. For both atria, LS declined with age and time-to-peak increased. Left ventricle LS declined minimally with age, but right ventricle free-wall LS augmented with age until the sixth decade. Conclusions— Simultaneous measurement of LS provides new insights into interchamber relationships. This new tool may prove useful in evaluating diseases that affect cardiac chambers differently.
Investigating the Synergistic Effects of Combined Modified Alginates on Macrophage Phenotype

Understanding macrophage responses to biomaterials is crucial to the success of implanted medical devices, tissue engineering scaffolds, and drug delivery vehicles. Cellular responses to materials may depend synergistically on multiple surface chemistries, due to the polyvalent nature of cell–ligand interactions. Previous work in our lab found that different surface functionalities of chemically modified alginate could sway macrophage phenotype toward either the pro-inflammatory or pro-angiogenic phenotype. Using these findings, this research aims to understand the relationship between combined material surface chemistries and macrophage phenotype. Tumor necrosis factor-α (TNF-α) secretion, nitrite production, and arginase activity were measured and used to determine the ability of the materials to alter macrophage phenotype. Cooperative relationships between pairwise modifications of alginate were determined by calculating synergy values for the aforementioned molecules. Several materials appeared to improve M1 to M2 macrophage reprogramming capabilities, giving valuable insight into the complexity of surface chemistries needed for optimal incorporation and survival of implanted biomaterials.
It’s Just a Feeling

The ultimate test of any ethics must be a practical one. This chapter looks at some of the difficulties that can arise in the effort to adopt the nonmoralistic ethics of desirism. The author draws the analogy of experiencing a dizzy spell while sitting in a chair; you can know very well that you are stock still, but you will feel you are whirling about all the same. Just so, it can be difficult to give up morality even if one is convinced of the benefits of desirism. Difficulties can arise even in the effort to demonstrate that it is desirism, and not some form of morality instead, that is what we are living when we think we are living as desirists.
Individual and combined contributions of the Ren barb1 , Ren barb2 , and Ren barb3 quantitative trait loci to reniform nematode ( Rotylenchulus reniformis Linford & Oliveira) resistance in upland cotton ( Gossypium hirsutum L.)

The infection of Upland cotton (Gossypium hirsutum L.) by the root parasite Rotylenchulus reniformis Linford & Oliveira, the reniform nematode, results in massive annual yield losses throughout the southeastern United States and portions of Texas. Resistance to reniform nematode was identified in the photoperiodic G. barbadense L. accession GB713. Previous research identified three quantitative trait loci (QTLs) that mediate GB713-derived reniform nematode resistance. Two of the QTLs reside next to each other on chromosome 21 (Ren barb1 and Ren barb2 ) while Ren barb3 was mapped to chromosome 18. In the present study, reniform nematode reproduction and fecundity was measured for eight G. hirsutum near isolines, developed through marker-assisted-selection (MAS), that represented every possible combination of Ren barb QTL genotypes. Our data clearly show that the Ren barb1 –Ren barb2 QTL interval can be resolved to a single QTL locus, i.e., Ren barb2 , that can be selected for in MAS using the BNL3279_106 SSR marker. Reniform nematode resistance equivalent to the GB713 parent was only obtained through combination of Ren barb2 and Ren barb3 ; however, Ren barb2 alone conferred an approximately 71% reduction in eggs gram−1 root compared to the susceptible check. The addition of Ren barb1 to isolines having only Ren barb2 or Ren barb3 did not improve resistance phenotypes. Adult reniform nematode females produced the same number of eggs per egg mass across all lines tested indicating that GB713-derived resistance does not manifest as a reduction in nematode fecundity. These findings streamline cotton MAS breeding programs by reducing the number of reniform nematode resistance loci that require tracking in segregating populations.
Software-based approach toward vendor independent real-time photoacoustic imaging using ultrasound beamformed data

Photoacoustic (PA) imaging has shown its potential for many clinical applications, but current research and usage of PA imaging are constrained by additional hardware costs to collect channel data, as the PA signals are incorrectly processed in existing clinical ultrasound systems. This problem arises from the fact that ultrasound systems beamform the PA signals as echoes from the ultrasound transducer instead of directly from illuminated sources. Consequently, conventional implementations of PA imaging rely on parallel channel acquisition from research platforms, which are not only slow and expensive, but are also mostly not approved by the FDA for clinical use. In previous studies, we have proposed the synthetic-aperture based photoacoustic re-beamformer (SPARE) that uses ultrasound beamformed radio frequency (RF) data as the input, which is readily available in clinical ultrasound scanners. The goal of this work is to implement the SPARE beamformer in a clinical ultrasound system, and to experimentally demonstrate its real-time visualization. Assuming a high pulsed repetition frequency (PRF) laser is used, a PZT-based pseudo PA source transmission was synchronized with the ultrasound line trigger. As a result, the frame-rate increases when limiting the image field-of-view (FOV), with 50 to 20 frames per second achieved for FOVs from 35 mm to 70 mm depth, respectively. Although in reality the maximum PRF of laser firing limits the PA image frame rate, this result indicates that the developed software is capable of displaying PA images with the maximum possible frame-rate for certain laser system without acquiring channel data.
Radiographic and computed tomography monitoring of a fractured needle fragment in the mandibular branch

Some complications can arise with the usage of local anesthesia for dental procedures, including the fracture of needles in the patient. This is a rare incident, usually caused by the patient's sudden movements during anesthetic block. Its complications are not common, but can include pain, trismus, inflammation in the region, difficulty in swallowing, and migration of the object, which is the least common but has the ability to cause more serious damage to the patient. This report describes a case in which, after the fracture of the anesthetic needle used during alveolar nerve block for exodontia of the left mandibular third molar, the fragment moved significantly in the first 2 months, before stabilizing after the third month of radiographic monitoring.
Environmental influences on the nesting phenology and productivity of Mississippi Kites (Ictinia mississippiensis)

ABSTRACT Identifying sources of annual variation in the reproductive success of a species may provide valuable insights into how the species may be affected by future environmental or climatic conditions. We examined annual variation in the nesting phenology, productivity, and apparent nest success of Mississippi Kites (Ictinia mississippiensis), a species common in urban areas in the southern Great Plains, from May through August. We monitored 498 Mississippi Kite nesting attempts in Lubbock, Texas, USA, between 2004 and 2015, from which we modeled daily survival rate as a function of local weather conditions, drought severity, and the state of the El Nino Southern Oscillation. We observed significant annual variation in median incubation initiation date (range = May 20 to June 5), the probability of nest success (range = 0.31–0.90), and productivity (range = 0.25–1.00 fledglings per nest). Our models of daily survival rate suggested that higher daily temperatures, severe storm events, extreme drought co...
Intraday price discovery analysis in the foreign exchange market of an emerging economy: Mexico

Abstract We analyze intraday price discovery in the spot and futures markets for an emerging economy’s flexible exchange rate: the U.S. dollar–Mexican peso (USD-MXN) rate. The futures and spot markets are cointegrated and significantly driven by the common factor. Both markets rapidly respond to the disequilibrium between markets in a minute. Overall the spot market moderately leads futures in price discovery. We also look at the impact of Mexican government interventions on price discovery and find interventions have a significant impact on price discovery.
Patient-provider relationship and perceived provider weight bias among American Indians and Alaska Natives.

SummaryObjective The objective of this study was to examine patient-provider relationships among American Indians and Alaska Native (AI/AN) patients by examining associations between patient activation, perceived provider weight bias, and working alliance. Patient activation is generally defined as having the knowledge, skills and confidence to manage one's health. Methods Among a sample of 87 AI/AN adults presenting for general medical care at an urban clinic in the northwest region of the United States, OLS regression analysis was completed to examine associations. Results Better working alliance scores were associated with increased patient activation, while perceived provider weight bias was associated with reduced patient activation. In addition, those with class II obesity had decreased patient activation. Conclusion These findings point to the importance of a positive patient-provider relationship in AI/ANs. Optimal patient engagement and subsequent health outcomes warrant additional consideration of patients' perceptions of provider weight bias within the context of health promotion and interventions.
Scalability and Sustainability in Uncertain Environments: Transition to Recovery from the 2015 Gorkha, Nepal, Earthquakes

The transition from response to recovery in Nepal following the 25 April and 12 May 2015 earthquakes represents an unusual set of tensions among political, economic, geographic, social, technical, ...
Critical Engagement: Integrating Spirituality and “Wisdom Sharing” into Higher Education Curriculum Development

This chapter proposes expanding Berling’s interreligious approach to one that can embrace the learning process of encountering difference for higher education students who identify as either religious or non-religious. An expanded approach incorporates a pedagogy which explicitly recognizes the transcendent or spiritual aspects of human experience outside of a religious framework. Rather than viewing Christianity, theology, and interreligious learning as elective subjects, a critical framework of spirituality, wisdom, and wisdom sharing can become an integral part of higher education curriculum development across disciplines. As pluralism increases in our society, a greater need arises for an appreciation and understanding of our common humanity. This expanded approach allows for student growth in cross-cultural values, such as mutuality, compassion, empathy, and justice as well as for an increased awareness of religious and non-religious wisdom traditions that promote individual and communal well-being.
MOLECULAR DYNAMICS SIMULATION OF INTERFACIAL TENSION OF ULTRA-THIN LIQUID FILMS ON A SOLID SURFACE

The effect of wall proximity on the interfacial tension of ultra-thin liquid films of Lennard-Jones (12,6) fluid has been studied using Molecular Dynamics Simulation. The wall’ s presence can potentially affect drop-wise condensation and other phase change phenomena such as boiling. Initially the LennardJones atoms are placed near a solid wall with FCC lattice structure in a doubly periodic box. Once equilibrated at a desired temperature, a thin liquid film forms on the solid wall. The surface tension of the liquid-vapor interface is computed statistically. When the film is thick ( 40 ˚ A), surface tension at the liquidvapor interface is found to be unaffected by the presence of the solid wall and matches bulk values reported for Argon. However for thinner films ( 15 ˚ A), surface tension of the liquid-vapor interface deviates from the macroscopic value. This has been investigated for various temperatures ranging from the triple point to the critical point. As the film thins further (1-2 molecules thickness), the liquid-vapor interface resembles a solid-vapor interface. Surface tension of this solid-vapor interface is evaluated for a solid wall modeled both by an equivalent interacted potential and discrete atoms. The two cases are found to yield different results. The Equivalent potential for the wall gives lower surface tension and liquid density near the solid wall compared to the discrete atoms case.
Output-Feedback Adaptive Control of Discrete-Time Systems with Unmodeled, Unmatched, Inaccessible Nonlinearities

We present a numerical investigation of output-feedback discrete-time adaptive control for a class of nonlinear systems. Systems with unknown nonlinearities that may be unmatched with the control are considered. The unknown nonlinearity is assumed to be inaccessible in the sense that it is a function of states that are not measured. For these systems, retrospective cost adaptive control is used for output-feedback stabilization, command following, and disturbance rejection.
Advances in mass spectrometry‐based glycoproteomics

Protein glycosylation, an important PTM, plays an essential role in a wide range of biological processes such as immune response, intercellular signaling, inflammation, and host-pathogen interaction. Aberrant glycosylation has been correlated with various diseases. However, studying protein glycosylation remains challenging because of low abundance, microheterogeneities of glycosylation sites, and poor ionization efficiency of glycopeptides. Therefore, the development of sensitive and accurate approaches to characterize protein glycosylation is crucial. The identification and characterization of protein glycosylation by MS is referred to as the field of glycoproteomics. Methods such as enrichment, metabolic labeling, and derivatization of glycopeptides in conjunction with different MS techniques and bioinformatics tools, have been developed to achieve an unequivocal quantitative and qualitative characterization of glycoproteins. This review summarizes the recent developments in the field of glycoproteomics over the past 6 years (2012 to 2018).
Comprehensive evaluation on treatment and outcomes of grade II diffuse gliomas.

e14025Background: Grade II gliomas include a variety of histologic features. Low grade gliomas are present in younger patients and have favorable prognosis. We aim to describe prognosis patterns of...
Post-Trial Sustainability and Scalability of the Benefits of a Medical Home for High-Risk Children with Medical Complexity.

Objective To assess the sustainability of the benefits relative to usual care of a medical home providing comprehensive care for high-risk children with medical complexity (≥2 hospitalizations or ≥1 pediatric intensive care unit [PICU] admission in the year before enrollment) after we made comprehensive care our standard practice and expanded the program. Study design We conducted pre-post comparisons of the rate of children with serious illness (death, PICU admission, or >7-day hospitalization) and health-system costs observed after program expansion (March 2014-June 2015) to those during the clinical trial (March 2011-August 2013) for each of the trial's treatment groups (usual care, n = 96, and comprehensive care, n = 105; primary analyses), and among all children given comprehensive care (nPost-trial = 233, including trial usual care children who transitioned to comprehensive care post-trial and newly enrolled medically complex children, and nTrial = 105; secondary analyses). We also analyzed the findings for the trial patients as a 2-phase stepped-wedge study. Results In intent-to-treat analyses, rates of children with serious illness and costs were reduced or unchanged post-trial vs trial for the trial's usual care group (rate ratio [RR], 0.36; 95% CI, 0.20-0.64; cost ratio [CR], 0.68; 95% CI, 0.28-1.68), the trial's comprehensive care group (RR, 0.74; 95% CI, 0.39-1.41; CR, 0.67; 95% CI, 0.51-0.89), and among all children given comprehensive care (RR, 0.97; 95% CI, 0.61-1.52; CR, 0.75; 95% CI, 0.61-0.93). Conservative stepped-wedge analyses identified overall benefits with comprehensive care across both study periods (RR, 0.46; 95% CI, 0.30-0.72; CR, 0.64; 95% CI, 0.43-0.99). Conclusions Major benefits of comprehensive care did not diminish with post-trial program expansion.
Technical Standards in Health and Safety Regulation: Risk Regimes, the New Administrative Law, and Food Safety Governance

Technical standards developed by nongovernment entities are an integral part of health and safety regulation. These “private” standards – produced by industry associations and standards development organizations – frequently inform health and safety guidance and rules issued by government agencies. In some industries, private health and safety standards are more rigorous than government regulations. Private standards may also be the only source of health and safety norms in the absence of government regulation. In addition, private standards govern an array of consulting, auditing, testing, and certification services, which play an essential role in monitoring and incentivizing standards conformity and regulatory compliance related to health and safety.
Rural Revitalization in New Mexico

The Rural Education Bureau of the New Mexico Public Education Department has established a program to address the special needs of schools and communities in the extensive rural areas of the state. High poverty rates, depopulation and a general lack of viable economic opportunity have marked rural New Mexico for decades. The program underway aims at establishing holistic community socioeconomic revitalization at the grass roots level with the schools playing a leading role. Initiatives include community conversations with key leaders to determine necessary steps to take in encouraging economic growth and attracting businesses, the institution of entrepreneurship within the community, the transformation of the school into a community resource and the encouragement of place-based education within schools. In the second year of this program there are 13 school districts actively involved in the enhancement of their schools and community. The program adopted many of the principles for rural revitalization seen in the remote communities of South Australia.
Compared to what? Media-guided reference points and relative economic voting

Abstract The idea of the relative economy, or benchmarking economic voting, has been around for a long time. However, the choice of international benchmark(s) remains underspecified, especially in cross-national and time-series studies. This paper argues that the selection process of benchmark(s) should be guided by the theory suggesting that voters benchmark countries that are similar, familiar, and connected, and that media guide voters to appreciate these reference points. Using domestic media coverage from Lexis-Nexis spanning 22 languages, 29 democracies, and over 30 years, this research identifies the unique reference points across time and space. Analysis of this novel dataset shows that voters react strongly to relative economic performance when they make vote choices. Moreover, the benchmarking effects become more pronounced with highly educated populations, but are not affected by clarity of responsibility.
American College of Surgeons National Surgical Quality Improvement Program assessment of risk factors for 30-day unplanned readmission in patients undergoing head and neck surgery requiring free tissue reconstruction.

Background Unplanned readmissions have become a metric for measuring quality of care. We analyzed the factors associated with 30-day unplanned readmission (30dUR) following head and neck cancer resections that included free tissue reconstruction (FTR). Methods The 2012-2014 ACS-National Surgical Quality Improvement Program (NSQIP) data set was queried. Univariate and multivariate logistic regression analyses were performed. Results Out of 1114 cases, 121 had a 30dUR. The most common reasons were wound complications, including incisional infections, hematoma, and hemorrhage. A significant independent risk factor for 30dUR included a clean/contaminated wound class (odds ratio [OR], 2.27; 95% confidence interval [CI], 1.20-4.76). Patients receiving an osseous FTR had lower readmission rates (OR, 0.51; CI, 0.27-0.91). Discharge destination had no statistical significance. Conclusions Based on the NSQIP data set, 10.9% of patients receiving an FTR for head and neck malignancy had a 30dUR. Although large, population-based data sets have limitations, these results elucidate that these patients are at an increased risk for unplanned readmissions, which can guide patient expectations and discharge planning.
The direct absorption measurement of fused silica, CaF2, MgF2, and sapphire at VUV and IR region

The absorption of fused silica, CaF2, MgF2, and sapphire at VUV region (193.4 nm) and IR region (1070 nm) were measured. For this measurement, LID (Laser Induced Deflection) method was used because of its high sensitivity. We report the degradation behavior of materials by comparison of absorption before and after ArF laser irradiation, and also the ultra-minute absorption at IR wavelength. At each wavelength, the absorption of low OH fused silica before the laser irradiation showed the smallest. At ArF wavelength, sapphire and CaF2 showed higher laser durability than MgF2 and fused silica. At IR wavelength, VUV-transmissive sapphire showed a lower absorption compared to general sapphire.
Cognitive Flexibility, Relativistic Appreciation, and Ethnocultural Empathy Among Chinese International Students:

Based on Berry’s (1997) framework, we investigated the mediating effect of cognitive flexibility and the moderating effect of relativistic appreciation on the association between acculturative stre...
Maximal Independent Fault Set for Gate-Exhaustive Faults

Dynamic test compaction procedures use independent fault sets to guide the generation of compact test sets. In addition, a maximal independent fault set provides a lower bound on the number of tests, and can thus be used for evaluating the level of test compaction. This article notes that defect-aware, cell-aware, and gate-exhaustive faults have certain properties that can be used in the computation of independent fault sets. This article focuses on gate-exhaustive faults and the computation of a maximal independent fault set. The experimental results for benchmark circuits support the discussion.
Energy Efficient Task Offloading for Compute-intensive Mobile Edge Applications

In mobile edge computing (MEC) systems, offloading real-time and compute-intensive application tasks to remote edge servers is performed to relieve energy-constrained mobile devices of energy consuming computations. However, such practice often becomes counter-productive as transmission power requirements to offload such real-time tasks through wireless can make the mobile devices spend significant energy. In this paper, we propose an energy-efficient task offloading scheme for real-time and compute-intensive applications that optimizes energy consumption at mobile devices without violating such applications' strict latency requirements. In particular, for local energy savings at the mobile devices, we propose a Computation and Power Optimization (CPO) algorithm for optimal job partitioning. Then we propose a multi-device and multi-server task Joint Task Offloading Game (JTOG) algorithm in order to minimize the energy consumption for all mobile devices generating multiple tasks. Finally, using a realistic and detailed simulation, we prove that a tractable Nash Equilibrium always exists for the game that optimizes the energy savings of all mobile devices. We also show that the proposed JTOG algorithm performs significantly better than other default full task offloading schemes in terms of overall energy savings.
Assays for protein-tyrosine phosphatases.

Many studies have implicated protein-tyrosine phosphatases (PTPases) as important regulators of cellular functions and as potential drug targets. This has led to an increased interest in the development of precise assays for detailed mechanistic studies of PTPases, rapid assays for high-throughput PTPase inhibitor screening, and more biologically relevant assays using physiological protein substrates. The first assays aimed specifically at PTPases utilized tyrosine-phosphorylated proteins such as myosin light chain LC 20 , insulin receptor, epidermal growth factor receptor, RCM-lysozyme, or myelin basic protein as substrates while 32 P i release was monitored as the readout of PTPase activity. The tyrosine-phosphorylated forms of other proteins and peptides such as Raytide, angiotensin II, glutamine synthase, and angiotensin II peptides have also been used as PTPase substrates. Studies involving phosphorylated, physiological substrates have also been carried out in which phosphoamino acid analysis, phosphopeptide mapping, and sodium dodecyl sulfate-polyacrylamide gel electrophoresis (SDS-PAGE) with phosphoimaging, were used to monitor PTPase activity.
Diagnosis and treatment of sheep and goat dyspnea

Causes of rapid or labored respiration in small ruminants include normal panting and treatable pathologic conditions such as bronchopneumonia, lungworms, anemia, and hypocalcemia. Several other causes of dyspnea such as caseous lymphadenitis, retroviral interstitial pneumonia, and neoplasia must be differentiated, as they carry a grave prognosis. This article will emphasize diagnosis and control of respiratory diseases, especially at the herd level.
CT Esophagography for Evaluation of Esophageal Perforation

Use of a standardized protocol for CT esophagography can improve image interpretation and treatment of patients with acute esophageal injury.
El debate entre nacionalismo y republicanismo en el pensamiento irreligioso de Gonzalo Puente Ojea

espanolSobre el trasfondo dialectico del problema general de la relacion entre la “cuestion nacional” y la “cuestion social” del marxismo, bajo el titulo “Nacionalismo e izquierda espanola” se problematiza tanto la relacion historica y actual entre las izquierdas y los nacionalismos espanoles (el unitario y los disgregadores), como las soluciones que se aportan para resolver un conflicto con posiciones cada vez mas enconadas e irreconciliables desde el reciente proceso separatista llevado a cabo a traves del Parlamento catalan. En su exposicion se tomara como punto de partida el planteamiento y la solucion al problema de una posicion nitidamente republicanista como la que expone Gonzalo Puente Ojea en su articulo titulado “El conflicto vasco”, de 2001, sometido a analisis y critica. EnglishOn the dialectical background of the general problem of the relationship between the “national question” and the “social question” of Marxism, under the title “The debate between nationalism and republicanism in the irreligious thought of Gonzalo Puente Ojea”, the historical and current relationship between the lefts and the Spanish nationalisms (the unitary and the disintegrators) is both problematized, such as the solutions provided to resolve a conflict with increasingly bitter and irreconcilable positions since the recent separatist process carried out through the Catalan Parliament. His presentation will take as its starting point the approach to and solution to the problem of a clearly republican position such as that set out by Gonzalo Puente Ojea in his article entitled “The Basque conflict”, 2001, subject to analysis and criticism.
Pressure sensitive paint measurements on a hemispherical turret

Surface pressure measurements were taken on a hemisphere-on-cylinder turret in a wind tunnel using pressure sensitive paint and fast response pressure transducers. Four different turret protrusion distances were tested to study the characteristics of the unsteady pressure field on the backside and wake of the turret. Proper orthogonal decomposition was used to identify the dominant spatial surface pressure modes acting on the turret in this parametric study. It was found that the further the turret protruded into the freestream flow, the more the surface pressure field became dominated by spanwise antisymmetric surface pressure distributions resulting from anti-symmetrical vortex shedding at a normalized frequency of approximately StD=0.2. For the case of the partial hemisphere, this anti-symmetrical vortex shedding was essentially absent, insinuating that at some protrusion distance, the surface pressure environment on the turret fundamentally changes. The normalized net force rms was calculated on the turret for each configuration. It was found that the greater the turret protrusion, the greater the net force acting in the spanwise direction.
Preparing for the age of therapeutic trials in frontotemporal lobar degeneration

Frontotemporal lobar degeneration (FTLD) comprises a spectrum of heterogenous clinicopathological neurodegenerative disorders and neuropathological examination at autopsy remains the gold standard for diagnosis.1 However, detection of pathogenic mutations in genes known to associate with either FTLD-Tau or FTLD-TDP neuropathology in ~20%–30% of all FTLD with familial disease provides an accurate antemortem molecular diagnosis in these individuals, even in the presymptomatic stage. Therefore, several clinical trials for agents targeting disease-specific mechanisms associated with forms of familial FTLD are planned or currently underway. Reliable clinical outcome measures to detect and track early disease are crucial to facilitate the success of these efforts. Peakman et al 2 perform a detailed cross-sectional and longitudinal analysis of two commonly used clinical rating scales (ie, extended clinical dementia rating scale (CDR+NACC FTLD) and the Frontotemporal Dementia Rating Scale (FRS)) in the large international …
Application of a myoelectric elbow flexion assist orthosis in adult traumatic brachial plexus injury: patient perspectives.

BACKGROUND Individuals with brachial plexus injuries (BPIs) can be prescribed assistive devices, including myoelectric elbow orthoses (MEOs), for rehabilitation or functional use after failed treatment for elbow flexion restoration. Although recent case studies indicate potential for clinical improvements after using an MEO after BPI, the patients' perspectives on such use are still unknown. OBJECTIVE To explore patient perspectives on the use of an MEO after surgical treatment for a traumatic BPI. STUDY DESIGN Qualitative using both a focus group and semistructured interviews. METHODS Patients with BPI that used an MEO were recruited. Five patients participated in an in-person focus group, whereas three patients participated in individual phone interviews. Themes that emerged from the focus group were compared against those that emerged from the personal interviews. RESULTS Feedback was grouped into three themes: device usage, hardware performance, and device design. Within each theme, positive elements, areas for improvement, and additional considerations emerged. Patients indicated a positive attitude toward using an MEO as a rehabilitation tool. They desired a streamlined, stronger device to support them and assist during activities of daily living. CONCLUSIONS For patients with BPI, a well-designed MEO that meets their needs could assist with rehabilitation and increase independence in daily activities. Continued patient engagement in the evaluation and development of both medical devices and treatment plans offers the best opportunity for improved outcomes that are important to the patient.
A Cryptic K48 Ubiquitin Chain Binding Site on UCH37 is Required for its Role in Proteasomal Degradation

Degradation by the 26S proteasome is an intricately regulated process fine-tuned by the precise nature of ubiquitin modifications attached to a protein substrate. By debranching ubiquitin chains composed of K48 linkages, the proteasome-associated ubiquitin C-terminal hydrolase UCHL5/UCH37 serves as a positive regulator of protein degradation. How UCH37 achieves specificity for K48 chains is unclear. Here, we use a combination of hydrogen-deuterium mass spectrometry, chemical crosslinking, small-angle X-ray scattering, NMR, molecular docking, and targeted mutagenesis to uncover a cryptic K48 ubiquitin chain specific binding site on the opposite face of UCH37 relative to the canonical S1 ubiquitin-binding site. Biochemical assays demonstrate the K48 chain-specific binding site is required for chain debranching and proteasome-mediated degradation of proteins modified with branched chains. Using quantitative proteomics, translation shutoff experiments, and linkage-specific affinity tools, we then identify specific proteins whose degradation depends on the debranching activity of UCH37. Our findings suggest that UCH37 and potentially other DUBs could use more than one S1 site to perform different biochemical functions.
Secondary herpes simplex virus latent infection in transplanted ganglia.

Abstract Sensory ganglia latently infected with herpes simplex virus (HSV) were transplanted beneath the renal capsule of syngeneic recipients, and the latent infection remaining was investigated. HSV latency-associated transcript (LAT) expression and reactivation of HSV after explant of transplanted dorsal root ganglia were monitored as markers of latency. Two to four weeks after transplantation, both indicated evidence of HSV latency in transplants. At those times, infectious virus was not detected in direct ganglion homogenates. In addition, viral antigen and infected cell polypeptide 4 RNA were not detected. Taken together, the results suggested that HSV latent infection rather than persistent infection was present in transplants. From these results, two explanations seemed possible: latency was maintained in transplanted neurons, or alternatively, latency developed after transplantation, in neurons not previously latently infected. The latter was considered putative secondary latency and was investigated in three ways. First, evidence of reactivation which might serve as a source for secondary latency was evaluated. Reactivation of HSV in transplants was evident from HSV antigen expression (52% of transplants) and the presence of cell-free virus (38% of transplants) 3 to 5 days after transplantation. Second, putative secondary latency was investigated in recipients immunized with HSV prior to receiving latently infected ganglia. Reactivation was not detected 3 to 5 days after transplantation in immunized recipients, and LAT expression was rare in these recipients after 3 to 4 weeks. Lastly, the possibility of secondary latency was investigated by comparing results obtained with standard HSV and with reactivation-defective thymidine kinase-negative (TK-) HSV. Defective reactivation of TK- HSV was demonstrated by immunohistochemistry and by the inability to isolate infectious virus. Donor dorsal root ganglia latently infected with TK+ HSV showed many LAT-positive neurons 2 or more weeks after transplantation (average, 26 per transplant). However, LAT expression was undetectable or minimal > 2 weeks after transplantation in donor ganglia latently infected with TK- HSV (average, 0.2 per transplant). Impaired reactivation of TK- HSV-infected donor ganglia after transplantation, therefore, was correlated with subsequent limited LAT expression. From these results, the occurrence of secondary latency was concluded for ganglia latently infected with TK+ HSV and transplanted beneath the kidney capsule. In vivo reactivation in this transplant model may provide a more useful means to investigate HSV reactivation than in usual in vitro explant models and may complement other in vivo reactivation models. The occurrence of secondary latency was unique. The inhibition of secondary latency by the immune system may provide an avenue to evaluate immunological control of HSV latency.
Thenon-solvable triangle transitive planes

The class of finite translation planes admitting non-solvable triangle transitive groups is completely determined as the class of irregular nearfield planes admitting non-solvable groups.
Effect of clomiphene citrate on oligospermia.

Abstract Clomiphene is thought to have an antiestrogenic effect and to enhance the release of gonadotropins from the pituitary. For these reasons, it was administered to 15 oligospermic infertile males that exhibited varying testicular derangements on biopsy to correlate any response with a particular histologic picture. Regardless of the pathology, no improvement in semen count was noted. In 4 cases, semen count depression followed therapy.
Abnormal bleeding in obstetrical and gynecological conditions

Abstract 1. There is often an increased protamine titration in normal pregnancy before delivery which returns to normal early in the puerperium. 2. The presence of an increased titration does not predict abnormal bleeding in pregnant women at delivery or in the puerperium. 3. If an increased protamine titration is present in a bleeding patient in whom no other demonstrable pathological cause is present, clinical trial of protamine sulfate and/or toluidine blue is indicated.
Development of a sorbent for carbon dioxide

iv INTRODUCTION 1 Calcination/Carbonation Reactions 3 Carbon dioxide Capture Processes 6 CO2 Capture for Hydrogen Production 8 CO2 Capacity Deterioration 10 Research Approach 11 LITERATURE REVIEW 13 The Optimization of Calcination Conditions 13 Incorporation of Inert Materials 17 Economic Analysis 22 EXPERIMENTAL MATERIALS AND METHODS 23 Materials 23 Sorbent Preparation Methods 24 Characterization Methods 28 Calculation Methods 30 EXPERIMENTAL RESULTS AND DISCUSSION 32 Application of the Calcination Process to Various Materials 32 Effect of Calcination Conditions on Absorption Capacity 38 Limestone as a Precursor for CaO 42 Dolomite as a Precursor for CaO 48 Stabilizing Effect of MgO 54 Extended Tests of Sorbent Stability 68 Effect of Particle Size 73
Cosmology and political culture in early China

List of illustrations List of tables Acknowledgements 1. Introduction 2. Sifang and the center: the cosmology of the ruling clan 3. Wuxing: cosmology in historical transition 4. Moralizing cosmology and transforming imperial sovereignty 5. Contesting emperorship: the center of the cosmos and pivot of power Conclusion: cosmology and power reconsidered List of abbreviations Works cited Index.
DYNAMICS AMONG POSTTRAUMATIC STRESS SYMPTOMS, FORGIVENESS FOR THE PERPETRATOR, AND POSTTRAUMATIC GROWTH FOLLOWING COLLECTIVE TRAUMA

Virginia TechTheory highlights forgiveness as a dynamic process that unfolds over time,as well as a potential target for posttrauma therapy. Longitudinal research,however, is nonexistent in the trauma literature. Further, the adaptation offorgiveness for understanding mass violent events has yet to be tested. Thecurrent study examined a theory-based hypothesis posing forgiveness as amediator between posttraumatic stress (PTS) symptoms and posttraumaticgrowth (PTG) in the context of a mass university campus shooting. Resultsshowed that forgiveness was a signiﬁcant mediator of the indirect, positiverelationship between Time 1 PTS and Time 1 and Time 2 PTG.Implications include considering mechanisms (e.g., forgiveness) that linkPTS and PTG for application in future research and practice.
A Possible Einstein-Podolsky-Rosen Probe of the Momentum-Position Uncertainty Relation

It is suggested that a measurement of the products of photoemission by alkali atoms excited after extraction from a trap, might, using the EPR strategy, show a significant violation of the momentum-position uncertainty relation. If this failed, as is quite likely, possible causes, such as retroactive propagation of influences and retrodiction failure, could be tested on the proposed apparatus.
TRAINING TEACHERS TO USE EVIDENCE‐BASED PRACTICES FOR AUTISM: EXAMINING PROCEDURAL IMPLEMENTATION FIDELITY

The purpose of this study was to examine the extent to which public school teachers implemented evidence-based interventions for students with autism in the way these practices were designed. Evidence-based practices for students with autism are rarely incorporated into community settings, and little is known about the quality of implementation. An indicator of intervention quality is procedural implementation fidelity (the degree to which a treatment is implemented as prescribed). Procedural fidelity likely affects student outcomes. This project examined procedural implementation fidelity of three evidence-based practices used in a randomized trial of a comprehensive program for students with autism in partnership with a large, urban school district. Results indicate that teachers in public school special education classrooms can learn to implement evidence-based strategies; however they require extensive training, coaching, and time to reach and maintain moderate procedural implementation fidelity. Procedural fidelity over time, and across intervention strategies is examined.
Low-Rank Approximation of Tensors

In many applications such as data compression, imaging or genomic data analysis, it is important to approximate a given tensor by a tensor that is sparsely representable. For matrices, i.e. 2-tensors, such a representation can be obtained via the singular value decomposition, which allows to compute best rank k-approximations. For very big matrices a low rank approximation using SVD is not computationally feasible. In this case different approximations are available. It seems that variants of the CUR-decomposition are most suitable. For d-mode tensors \(\mathcal{T} \in \otimes _{i=1}^{d}\mathbb{R}^{n_{i}}\), with d > 2, many generalizations of the singular value decomposition have been proposed to obtain low tensor rank decompositions. The most appropriate approximation seems to be best (r 1, …, r d )-approximation, which maximizes the l 2 norm of the projection of \(\mathcal{T}\) on ⊗ i = 1 d U i , where U i is an r i -dimensional subspace \(\mathbb{R}^{n_{i}}\). One of the most common methods is the alternating maximization method (AMM). It is obtained by maximizing on one subspace U i , while keeping all other fixed, and alternating the procedure repeatedly for i = 1, …, d. Usually, AMM will converge to a local best approximation. This approximation is a fixed point of a corresponding map on Grassmannians. We suggest a Newton method for finding the corresponding fixed point. We also discuss variants of CUR-approximation method for tensors. The first part of the paper is a survey on low rank approximation of tensors. The second new part of this paper is a new Newton method for best (r 1, …, r d )-approximation. We compare numerically different approximation methods.