cssi/SciSciGPT-SciSciNet huggingface dataset:
Primary Sjögren Syndrome in a Child with a Neuromyelitis Optica Spectrum Disorder

To the Editor: Neuromyelitis optica spectrum disorders (NMOSD) are a group of rare autoimmune diseases typically affecting women in their 40s and 50s, as does Sjogren syndrome (SS), another autoimmune disease. We describe a 6-year-old girl who presented with clinical and laboratory findings of both an NMOSD and SS. A 6-year-old previously healthy Korean girl presented with a 1-day history of fever, headache, progressive right-sided weakness, and altered mental status. Cerebrospinal fluid (CSF) analysis revealed an elevated protein without pleocytosis or oligoclonal bands. Magnetic resonance imaging (MRI) of the spinal cord showed contiguous T2 hyperintensity, and MRI of the brain showed extensive white matter lesions bilaterally (Figure 1), suspicious for demyelinating disease. She was treated with high-dose methylprednisolone, resulting in marked improvement, and continued treatment with tapering doses of prednisone, but flared when the prednisone was discontinued. Figure 1. A. MRI of the cervical and thoracic spine (T2 FLAIR with contrast shown) obtained at the onset of symptoms, prior to treatment. There is a contiguous hyperintense, centrally located spinal cord lesion. B. MRI of the head (T2 FLAIR with contrast shown) obtained at the … Address correspondence to Dr. G. Janow, Section of Pediatric Rheumatology, Joseph M. Sanzari Children’s Hospital, Hackensack University Medical Center, 30 Prospect Ave., WFAN Bldg. 3rd Floor, Hackensack, New Jersey 07601, USA. E-mail: GJanow{at}HackensackUMC.org
Coarctation in Taussig-Bing malformation of the heart. Surgical significance.

In a review of 126 heart specimens of simple complete transposition of the great arteries with ventricular septal defect (VSD), coarctation was noted in eight (6%). In 105 Taussig-Bing heart specimens, coarctation and/or aortic outflow tract obstruction was noted in 56 (53%) (p
How I diagnose and treat neutropenia

Purpose of review Neutropenia absolute neutrophil count (ANC) less than 1.5 × 10(9)/l is a common hematological finding, and severe neutropenia, that is, ANC less than 0.5 × 10(9)/l is a well known risk factor for susceptibility to bacterial infections. This review provides a succinct clinical approach to the diagnosis and treatment of neutropenia with specific recommendations on the treatment of severe chronic neutropenia with the myeloid growth factor, granulocyte colony-stimulating factor (G-CSF). Recent findings Experts agree that patients with acute febrile neutropenia should be treated with antibiotics and that patients at high risk of severe neutropenia (>20% risk) after myelosuppressive chemotherapy should be treated prophylactically with a myeloid growth factor, usually G-CSF. The diversity of causes and consequences of chronic neutropenia make the diagnosis and management of these patients more complicated. Summary The review provides a stepwise approach to neutropenia focusing first on reaching a provisional diagnosis and treatment plan then steps to a final diagnosis. It also provides specific recommendations on the treatment of severe chronic neutropenia with G-CSF.
Othering and Fear: Cultural Values and Hiro's Race in Thomas & Friends' Hero of the Rails

Television is a significant socialization tool for children to learn about their social worlds. The children's brand, Thomas & Friends, targets preschool audiences with manifest messages about friendship and utility as well as troubling, latent messages about race, ethnicity, and difference. Through critical visual and verbal discursive analyses of the film, Hero of the Rails, we expose Thomas & Friends' investment in racial hierarchies despite its broader message of friendship. We identify four ways that Hiro is “othered” in the film: (1) his glamorized description as “strange,” (2) his consistently heavily accented voice, (3) his Japanese origin story, and (4) his pigmentation and powerlessness. Using theories of “othering,” we argue that the representation of cultural difference to the preschooler audience is fearful and propagates racist discourses of yellow peril and Orientalism.
Clark after Haymarket

In the period 1887–1890, one observes a marked change in Clark’s position in a number of related areas. There is increasingly less argumentation based on divine law, this position eventually disappearing from the discussion altogether;1 now science, particularly that of Darwin, takes a dominant position. Second, Clark’s general theoretical perspective takes on a more conservative slant; it is increasingly less critical of prevailing arrangements and no longer promotes his supposedly ‘socialist’ solution to the problems then facing the United States economic order.
The Neoconservative Revolution: The Neoconservative Assault on the Counterculture

Neoconservatives viewed the collapse of the Soviet Union as their ultimate victory. A neoconservative ally, Francis Fukuyama, described the event as the “end of history.” Midge Decter, seeing no further need for the Committee for the Free World, shut it down. Even as neocons celebrated, however, many remained uneasy. The counterculture, they felt, had become institutionalized on college campuses, in many sectors of the media, and in the politics of the nation. Writing in The National Interest in 1993, not long after Bill Clinton won election, Irving Kristol declared, There is no ‘after the Cold War’ for me. So far from having ended, my Cold War has increased in intensity, as sector after sector has been ruthlessly corrupted by the liberal ethos. Now that the other Cold War is over, the real Cold War has begun. We are far less prepared for this Cold War, far more vulnerable to the enemy, than was the case with our victorious war against a global Communist threat. Success in the Cold War, in short, had little meaning for neocons if the broader culture continued to spin out of control. It was less that the old rules and values were ignored or flouted than that the newer ethos seemed to suggest that there were no rules. Morality was simply a matter of individual choice, and moral relativism had become the new norm. The counterculture sought acceptance for what neocons and many ordinary Americans considered to be bizarre ideas and behavior.
Wafer-level packaged SAW filters with resistance to transfer molding

A wafer-level-packaging technology is proposed to realize small SAW filters with low profiles that are resistant against transfer molding. Structural design considerations are described as well as the experimental results. It is shown that the proposed WLP SAW filters are suitable for the applications to RF front-end modules which are transfer molded with ICs.
Elevated vascular resistance after labetalol during resection of a pheochromocytoma (brief report).

Purpose To report a case of pheochromocytoma exhibiting an increase in systemic vascular resistance index (SVRJ) and decreased cardiac index (CI) after use of labetalol.
Diagnosis of Inherited Neuromuscular Disorders by Next-Generation–Sequencing

Inherited neuromuscular disorders (NMD) form a group of genetic diseases that result in long-term disability. The total incidence of NMD is greater than 1 in 3,000 and comprises a group of more than 200 monogenic disorders (Emery 1991). For about half of the cases, the molecular cause has not been identified. An extensive clinical evaluation with complementary gene-by-gene testing is often required to reach an exact diagnosis. Due to the presence of genetic heterogeneity and lack of segregation in sporatic cases, reaching a diagnosis is challenging, lengthy, and expensive. The genetic heterogeneity can be demonstrated by the number of genes involved in specific subgroups of NMD, namely, hereditary sensorimotor neuropathies (HSMN; 50 genes) and congenital muscular dystrophies (12 genes; North 2008; Valencia et al. 2013). In other instances, some NMD genes are very large and are not sequenced completely because it is costly and labor-intensive to sequence by the Sanger method. For the patient, this gene-by-gene approach increases the number of tests that are required, thus, delaying the diagnosis and exposing the patient to unnecessary investigations and treatments, precluding the full benefit of a targeted approach to treatment, and increasing recurrence risk in the families (Vasli et al. 2012).
Imaging nanotherapeutics in inflamed vasculature by intravital microscopy

Intravital microscopy (IVM) is the application of light microscopy to real time study biology of live animal tissues in intact and physiological conditions with the high spatial and temporal resolution. Advances in imaging systems, genetic animal models and imaging probes, IVM has offered quantitative and dynamic insight into cell biology, immunology, neurobiology and cancer. In this review, we will focus on the targeting of nanotherapeutics to inflamed vasculature. We will introduce the basic concept and principle of IVM and demonstrate that IVM is a powerful tool used to quantitatively determine the molecular mechanisms of interactions between nanotherapeutics and neutrophils or endothelium in living mice. In the future, it is needed to develop new imaging systems and novel imaging contrast agents to better understand molecular mechanisms of tissue processing of nanotherapeutics in vivo.
Using Teacher Effectiveness Data for Information-Rich Hiring.

Purpose: New teacher effectiveness measures have the potential to influence how principals hire teachers as they provide new and richer information about candidates to a traditionally information-poor process. This article examines how the hiring process is changing as a result of teacher evaluation reforms. Research Methods: Data come from interviews with more than 100 central office personnel and 76 principals in six urban school districts and two charter management organizations. These sites were systematically sampled based on the amount of time and resources devoted to creating data systems and implementing processes that allow principals access to teacher effectiveness data. In addition to the fieldwork, we also surveyed all principals in six of the eight systems. A total of 795 principals responded to the survey, with an overall response rate of 85%. Findings: The findings suggest that while teacher effectiveness data can be used to inform hiring decisions there is variation in how and the extent t...
Transgressing the father figure: performing queer theology as an act of liberation

This chapter examines the intersection of power, ritual, and the sacred through the lens of performing drag as a tool to subvert dominant notions of theological discourse. Grounded in Cheng’s asser...
Toward a Progress Indicator for Machine Learning Model Building and Data Mining Algorithm Execution: A Position Paper

For user-friendliness, many software systems offer progress indicators for long-duration tasks. A typical progress indicator continuously estimates the remaining task execution time as well as the portion of the task that has been finished. Building a machine learning model often takes a long time, but no existing machine learning software supplies a non-trivial progress indicator. Similarly, running a data mining algorithm often takes a long time, but no existing data mining software provides a nontrivial progress indicator. In this article, we consider the problem of offering progress indicators for machine learning model building and data mining algorithm execution. We discuss the goals and challenges intrinsic to this problem. Then we describe an initial framework for implementing such progress indicators and two advanced, potential uses of them, with the goal of inspiring future research on this topic
Protein mover’s distance: A geometric framework for solving global alignment of PPI networks

A protein-protein interaction (PPI) network is an unweighted and undirected graph representing the interactions among proteins, where each node denotes a protein and each edge connecting two nodes indicates their interaction. Given two PPI networks, finding their alignment is a fundamental problem and has many important applications in bioinformatics. However, it often needs to solve some generalized version of subgraph isomorphism problem which is challenging and NP-hard. Following our previous geometric approach [21], we propose a unified algorithmic framework for PPI networks alignment. We first define a general concept called “Protein Mover’s Distance (PMD)” to evaluate the alignment of two PPI networks. PMD is similar to the well known “Earth Mover’s Distance”; however, we also incorporate some other information, e.g., the functional annotation of proteins. Our algorithmic framework consists of two steps, Embedding and Matching. For the embedding step, we apply three different graph embedding techniques to preserve the topological structures of the original PPI networks. For the matching step, we compute a rigid transformation for one of the embedded PPI networks so as to minimize its PMD to the other PPI network; by using the flow values of the resulting PMD as the matching scores, we are able to obtain the desired alignment. Also, our framework can be easily extended to joint alignment of multiple PPI networks. The experimental results on two popular benchmark datasets suggest that our method outperforms existing approaches in terms of the quality of alignment.
Coupled Indoor Navigation for People Who Are Blind

This paper presents our design of an autonomous navigation system for a mobile robot that guides people who are blind and low vision in indoor settings. It begins by presenting user studies that shaped our design of the system, moves on to describing our model of human-robot coupled motion, and concludes by describing our autonomous navigation system.
HATs and HDACs

DNA in eukaryotes is arranged into higher order structures termed chromatin. Chromatin poses an obstacle for gene transcription because it is not readily accessible to DNA binding transcription factors. Chromatin also provides the structural basis for gene regulation, keeping most genes in a default state of repression. The regulation of gene expression involves dynamic chromatin remodeling associated with reversible histone acetylation. The enzymes that catalyze histone acetylation (HAT) and deacetylation (HDAC) are critical elements that regulate chromatin dynamics and gene expression. These chromatin-modifying enzymes are recruited to the genome by DNA binding transcription factors and are the key effectors that control chromatin structure. HAT and HDAC proteins are important in both normal cellular physiology and disease states. The recent identification of a large number of non-histone substrates for HATs and HDACs suggest even broader biological functions for these versatile enzymes.
Minimally Invasive Treatment for Brain Tumors

Minimally invasive techniques have significantly changed our ability to do expert and safe surgery for brain tumors. These techniques include neuroendoscopy, image-guided surgery in the traditional operating room, intraoperative imaging, radiosurgery, laser hypothermia, and focused ultrasound. With these, the contemporary neurosurgical oncologist has a powerful armamentarium to help in the management of brain and spinal cord tumors.
Fixed rings of generalized Weyl algebras

Abstract We study actions by filtered automorphisms on classical generalized Weyl algebras (GWAs). In the case of a defining polynomial of degree two, we prove that the fixed ring under the action of a finite cyclic group of filtered automorphisms is again a classical GWA, extending a result of Jordan and Wells. Partial results are provided for the case of higher degree polynomials. In addition, we establish a version of Auslander's theorem for finite cyclic groups of filtered automorphisms acting on classical GWAs.
Advancing the Civil Rights Movement: Race and Geography of Life Magazine's Visual Representation, 1954–1965: By Michael DibariLanham, MD: Lexington Books, 2017, 149 pp.

Once in 1965, when Life photographer Flip Schulke saw African American children being pushed to the ground at a 1965 civil rights protest, he paused from taking pictures and offered help to the fal...
Management of Next-Generation NAND Flash to Achieve Enterprise-Level Endurance and Latency Targets

Despite its widespread use in consumer devices and enterprise storage systems, NAND flash faces a growing number of challenges. While technology advances have helped to increase the storage density and reduce costs, they have also led to reduced endurance and larger block variations, which cannot be compensated solely by stronger ECC or read-retry schemes but have to be addressed holistically. Our goal is to enable low-cost NAND flash in enterprise storage for cost efficiency. We present novel flash-management approaches that reduce write amplification, achieve better wear leveling, and enhance endurance without sacrificing performance. We introduce block calibration, a technique to determine optimal read-threshold voltage levels that minimize error rates, and novel garbage-collection as well as data-placement schemes that alleviate the effects of block health variability and show how these techniques complement one another and thereby achieve enterprise storage requirements. By combining the proposed schemes, we improve endurance by up to 15× compared to the baseline endurance of NAND flash without using a stronger ECC scheme. The flash-management algorithms presented herein were designed and implemented in simulators, hardware test platforms, and eventually in the flash controllers of production enterprise all-flash arrays. Their effectiveness has been validated across thousands of customer deployments since 2015.
Chronic myeloid leukemia: 2018 update on diagnosis, therapy and monitoring

Disease overview Chronic myeloid leukemia (CML) is a myeloproliferative neoplasm with an incidence of 1-2 cases per 100 000 adults. It accounts for approximately 15% of newly diagnosed cases of leukemia in adults. Diagnosis CML is characterized by a balanced genetic translocation, t(9;22)(q34;q11.2), involving a fusion of the Abelson gene (ABL1) from chromosome 9q34 with the breakpoint cluster region (BCR) gene on chromosome 22q11.2. This rearrangement is known as the Philadelphia chromosome. The molecular consequence of this translocation is the generation of a BCR-ABL1 fusion oncogene, which in turn translates into a BCR-ABL1 oncoprotein. Frontline therapy: Four tyrosine kinase inhibitors (TKIs), imatinib, nilotinib, dasatinib, and bosutinib are approved by the United States Food and Drug Administration for first-line treatment of patients with newly diagnosed CML in chronic phase (CML-CP). Clinical trials with second generation TKIs reported significantly deeper and faster responses; this has not translated into improved long-term survival, because of the availability of effective salvage therapies. Salvage therapy: For patients who fail frontline therapy, second-line options include second and third generation TKIs. Second and third generation TKIs, although potent and selective, exhibit unique pharmacological profiles and response patterns relative to different patient and disease characteristics, such as patients' comorbidities, disease stage, and BCR-ABL1 mutational status. Patients who develop the T315I "gatekeeper" mutation display resistance to all currently available TKIs except ponatinib. Allogeneic stem cell transplantation remains an important therapeutic option for patients with CML-CP who have failed at least 2 TKIs, and for all patients in CML advanced phases.
Pairing vagus nerve stimulation with tones drives plasticity across the auditory pathway

Previous studies have reported primary auditory cortex plasticity following vagus nerve stimulation (VNS) paired with a sound. This study extends previous findings by documenting that fields across...
Woodcock-Johnson Tests of Cognitive Ability (W-J)

The WJ-R Cog was published in 1989 as a revision to the 1977 edition. While this chapter focuses on the cognitive battery, the W-J actually represents one of the most comprehensive test batteries available for the clinical assessment of children and adolescents. The W-J Tests of Achievement have enjoyed considerable popularity since their original release, probably more so than the cognitive battery. The system also includes the W-J Scales oflndependent Behavior (SIB), an adaptive behavior scale, among other components.
Labored Learning: The Outing System at Sherman Institute, 1902-1930

J after sunset on June 5, 1925, Dick Foinill jumped down from the bed of an oversized truck and touched his feet to the dusty Kansas soil for the first time. Foinill and twenty-four Navajos from near Tuba City, Arizona, had just completed a long journey crowded shoulder to shoulder into the bed of a pickup. For five days and four nights, they rode northeast from Tuba City through the mountains and high deserts of Arizona, New Mexico, and Colorado. After arriving on the high plains of Kansas, Foinill and his companions worked there for two months. Ten hours a day, they stooped in the dreadful Kansas heat and humidity, topping and harvesting sugar beets. The labor would be performed under the auspices of the “outing program” of Sherman Institute, an Indian boarding school in Riverside, California.1 According to reformers, bureaucrats, and Indian schools administrators, such work would inculcate young Indians with the prerequisite qualities of racial “uplift”: thrift, economy, and a willingness to work. All of this would be done for the wages of a migrant laborer. Torturously long days, shoddy living quarters, and inadequate food made employer-run living quarters hellish places on other farms that utilized migrant labor. This one would likely be much the same.2 Despite these looming challenges, Foinill awoke on his first morning in Kansas filled with excitement rather than dread. Before trudging out to the fields for the first time, he wrote a letter to his love interest back at Sherman
Intrinsic Qualities of Experience: Surviving Harman's Critique

Gilbert Harman (1990) seeks to defend psychophysical functionalism by articulating a representationalist view of the qualities of experience. The negative side of the present paper argues that the resources of this representationalist view are insufficient to ground the evident distinction between perception and (mere) thought. This failure makes the view unable to support the uses to which Harman wishes to put it. Several rescuing moves by other representationalists are considered, but none is found successful. Part of the difficulty in Harman's work is that he does not adequately specify the view he rejects. The positive aim of the present paper is to provide a robust intrinsic quality account of experience that offers advantages in comparison with Harman's view, and that plainly does not fall to any of the arguments he advances.
Reviewing the risk of feed as a vehicle for swine pathogen transmission

Background While porcine biological hazards have had the potential to be transmitted through feed and feed mills for decades, the emerging threat of foreign animal disease has elevated the concern that these may enter or be transmitted throughout the domestic swine herd via a feed vehicle. Objective The goal of this review was to describe the current classification for emerging porcine biological pathogen transmission through the feed supply chain so resources can be best directed towards those of highest risk. Methods By assessing the pathogen severity to pigs and the probability of pathogen transmission through feed, an overall risk can be established using a hazard analysis matrix. Results There is negligible risk for feed-based transmission of a transmissible spongiform encephalopathy, Trichinella spiralis, Toxoplasma gondii, Salmonella Choleraesuis, Salmonella spp. except Choleraesuis and I 4,[5],12:i:-, porcine deltacoronavirus, Senecavirus A, mammalian orthoreovirus 3, foot and mouth disease virus, classical swine fever virus or Chinese pseudorabies virus. However, the combined severity and probability of Salmonella enterica serotype I 4,[5],12:i:-, porcine epidemic diarrhoea virus and African swine fever virus warrant a moderate risk characterization for transmission through the US feed supply chain. Conclusions This risk can be maintained below critical status by minimizing the likelihood that a pathogen can enter the feed supply chain, such as by excluding high-risk ingredients from facilities, extending biosecurity to mills, and considering proactive mitigation strategies. In reality, all these actions may be necessary to prevent the detrimental transmission of porcine biological hazards into the US swine herd through the feed supply chain.
Leading Edge Bluntness and Slip Flow Effects in High Temperature Hypervelocity Flow Over a Flat Plate

An investigation was conducted in a hypersonic shock tunnel to study the effects of leading edge bluntness on rarefied hypersonic flow over a flat plate. The free stream Mach number range was 7.80–25.4 with corresponding stagnation temperatures of 2600° and 7000 ° R. For these test conditions, the strong interaction parameter , χ = M 1 3 /√ Re x , varied from 2.46 to 658. The leading edge Knudsen number varied from 0.011 to 2.14 with a leading edge thickness of 0.035 in . Schlieren photographs at these test conditions indicated the existence of a detached shock wave for a Knudsen number range of 0.011–0.076. When the Knudsen number is approximately 0.011 or less, the leading edge can be considered blunt resulting in an increase in the heat transfer rates over the case of a sharp flat plate. As the Knudsen number increases, the shock wave is not detached and the strong shock wave and boundary layer are delayed in forming due to slip flow phenomenon at the leading edge . The heat transfer results for a stagnation temperature of 2600 ° R, flow Mach number range of 15.9-25.4, and Knudsen number of 0.024–0.168 indicate that bluntness and slip flow effects are small. In addition, the heat transfer coefficient agreed reasonably well with the theoretical prediction of Li and Nagamatsu for a non-insulated flat plate . At the higher stagnation temperature of 7000 ° R with some real gas effects the Knudsen number varied from 0.076 to 2.14, with corresponding flow Mach numbers of 7.80–18.0. At these conditions the leading edge slip flow drastically lowered the heat transfer rates near the leading edge as compared to the theoretical prediction with no slip .
The Microgeometry of Dense Random Packings

Summary There are a variety of different approaches to the characterization of the local geometry in a random packing of particles. This paper gives a brief review of several different methods, with concentration on those methods which describe the geometry of groups of particles which surround the cavities between the particles.
The Influence of Political Regime on State-Level Disciplinary Actions of CPAs Sanctioned by the PCAOB

We investigate whether enforcement is influenced by politics by comparing the severity of PCAOB sanctions of individual CPAs to the severity of related state-level disciplinary actions imposed by boards of accountancy (BOAs). Our results provide evidence that when responding to PCAOB sanctions, BOAs under Republican regimes impose less severe penalties than do BOAs under Democratic regimes. Our data and analyses inform the regulatory and enforcement practices of the accounting profession and other professions. Most directly, motivated by improvements in technology that facilitate the cross-jurisdiction practice of public accounting, states have adopted mobility laws where CPAs are only required to be licensed in their state of residence to practice in multiple states. These laws simplify licensing but may complicate enforcement. Beyond generalized red-state, blue-state differences in enforcement, we find that non-resident CPAs receive less severe disciplinary actions. If not reasonably consistent across BOAs, regulators may be unwilling to delegate responsibility for enforcement to another state's BOA.
DETERMINATION OF SPACE GROUP OF PrCo_(12)B_6 COMPOUND BY COVERGENT BEAM ELECTRON DIFFRACTION

The space group of PrCo_(12)B_6 compound has been determined using the convergent beam electron diffraction method. The space group is found to be R3m.
Place-Based Learning Through a Proxy - Variations in the Perceived Benefits of a Virtual Tour

Place-based and fieldwork learning play a key role in higher education in environmental sciences and other geospatial disciplines. We report on a study in which we evaluated a web-based virtual tour application for teaching natural resource management in fire-prone western forests in two undergraduate classes. The virtual tour uses 360°-image-based virtual scenes and pre-recorded audio commentary by a domain expert to lead participants through the Stanislaus-Tuolumne Experimental Forest where forest treatments were implemented to reduce fire hazard. We present results from assessing students' overall perception of the virtual tour, their views towards its application in undergraduate education, and their feedback for improving the design of future virtual tours. Furthermore, we discuss the collected data from the perspective of gender differences and differences in familiarity with the topic of the tour.
Transfer Student Experiences and Identity Navigation in STEM: Overlapping Figured Worlds of Success.

Successful transitions from community colleges to the university setting are essential for increasing the number of transfer students who complete science, technology, engineering, and mathematics ...
Mode Shape Recognition of Complicated Spatial Beam-Type Structures via Polynomial Shape Function Correlation

The mode shapes of many beam-type structures, such as aircraft wings and wind turbine blades, involve a high degree of coupling between flap-wise and edge-wise bending deformations. In the case of wind turbine blades, the principal bending deformations (flap-wise deformation and edge-wise deformation) are typically easily recognized by visual observation. However, this visual approach is sometimes challenging for high-order mode shapes that have complex mode deformation. More importantly, visual observation cannot quantify the contribution of different deformation components for each mode. This work proposes a novel mode shape recognition algorithm, called Mode Shape Recognition Matrix (MSRM), for application to complicated spatial beam-type structures not only to identify the deformation components of the complex beam mode shapes, but more importantly, to quantify their respective relative contribution. In the application case studied for the MSRM method, a three-dimensional wind turbine blade is mapped into three-dimensional Chebyshev polynomial space. The blade mode shape is correlated to each polynomial shape function to find the contribution of each polynomial shape function for the mode shape. To validate the mode shape recognition performance, MSRM is applied on both numerical mode shapes from a fidelity blade finite element model and experimental mode shapes from a high spatial resolution 3D SLDV modal test. Both numerical and experimental studies demonstrate that MSRM can successfully recognize the quantitative contribution of flap-wise deformation and edge-wise deformation for each wind turbine blade mode shape.
Self-assembly of designed precursors: A route to crystallographically aligned new materials with controlled nanoarchitecture

Abstract Modulated elemental reactants is a method by which new and complex intergrowth compounds can be synthesized by the self-assembly of designed precursors prepared by physical vapor deposition. Careful calibration of the composition and thickness of the precursors ensures the formation of the desired product by precise control of local composition and diffusion lengths. Superstructures of increasing complexity can be realized using binary and ternary systems as starting points. The synthesis of systems based on three different binary compounds, either alloyed together or separated into distinct layers, expands the number of possible superstructures that can be formed using this technique, but provides analytical challenges. The synthesis of [(SnSe)1.15]1([TaxV1−x]Se2)1[(SnSe)1.15]1([VyTa1−y]Se2)1 compound is used to illustrate the preparation of precursors and the challenges in both measuring and limiting the interdiffusion of layers during self-assembly. Systematic changes in the electrical properties of (SnSe)1+δ(TaxV1−x)Se2 alloys are observed as x is varied. The electrical resistivity of [(SnSe)1.15]1([TaxV1−x]Se2)1[(SnSe)1.15]1([VyTa1−y]Se2)1 can be modeled as the two constituent layers in parallel.
Algunos métodos generales para la construcción de tests paramétricos y no paramétricos

Se construyen algunos tests para varias hipotesis parametricas y no parametricas. La metodologia utiliza un nuevo sistema de coordinados, cuyos componentes son el estadistico suficiente minimo y un estadistico independiente y complementario a tal estadistico.
Three aspects of the law of the sea

legal regime relating to islands, delimitation of zones of maritime jurisdiction and dispute settlement. The development of provisions relating to these topics is described and the present status as set down in the Informal Composite Negotiating Text (ICNT) analysed from a legal perspective. Three propositions relating to islands in maritime jurisdiction, the median line principle in delimitation, and third party dispute settlement procedures, are discussed and applied to the current provisions. Their adoption by UNCLOS and their value in facilitating the regulation of these issues are considered.
4.3.1 Systems Engineering Tradeoff Study Process Framework

Tradeoff studies are a critical tool to provide information to support decision making for discipline engineers, systems engineers, and program managers throughout the system life cycle. Unfortunately, the quality of trade studies is inconsistent between organizations and within organizations. This paper reports on part of an INCOSE effort to improve tradeoff studies and discusses a proposed INCOSE Decision Management Process aligned with ISO/IEC 15288. The proposed process discussed in this paper integrates decision analysis best practices with systems engineering activities to create a baseline from which future papers can explore possible innovations to further enhance tradeoff study quality. The process enables enterprises to develop an in-depth understanding of the complex relationship between requirements, the design choices made to address each requirement, and the system level consequences of the sum of design choices across the full set of performance requirements as well as other elements of stakeholder value to include cost and schedule. Through data visualization techniques, decision makers can quickly understand and crisply communicate a complex trade-space and converge on recommendations that are robust in the presence of uncertainty.
Cardiovascular Risk Factors in Women

Cardiovascular disease (CVD) is the leading cause of death and disability for women in the United States. Most of the risk factors for CVD and benefits of risk reduction are similar in women and men with some risk factors varying in magnitude and other risk factors unique in women. Even though heart disease remains the leading cause of mortality in women, healthy life style changes in addition to modification of traditional risk factors for CVD can impact positively on the incidence of CVD. Inspite of known benefits, CVD risk reduction strategies are underused. Prevention and treatment strategies in women need to be more aggressive. The CVD risk factors in women and benefits of risk factor modification are reviewed here.
Biochemical Characteristics of Vibrio sputorum and Relationship to Vibrio bubulus and Vibrio fetus

Loesche, Walter J. (Forsyth Dental Center and Harvard School of Dental Medicine, Boston, Mass.), Ronald J. Gibbons, and Sigmund S. Socransky. Biochemical characteristics of Vibrio sputorum and relationship to Vibrio bubulus and Vibrio fetus. J. Bacteriol. 89:1109-1116. 1965.-Twenty-seven strains of Vibrio sputorum were isolated from human gingival debris. All strains reduced nitrate beyond nitrite, and all produced H(2)S. None produced catalase, indole, or acetylmethylcarbinol. Carbohydrates were not fermented, and acid end products or volatile neutral products could not be detected. Motility was observed infrequently, although 14-hr cultures usually had a few cells which displayed darting motility. Shadowed electron microscopic preparations demonstrated that most cells in a given culture were nonflagellated, although some cells with a single terminal or subterminal flagellum were always observed. V. sputorum was demonstrated not to be a strict anaerobe as previously described, but rather a microaerophile. Addition of nitrate to culture media markedly enhanced growth. V. sputorum was found to be closely related to the animal microaerophilic vibrios, V. bubulus and V. fetus. V. sputorum differed from V. fetus by being capable of anaerobic growth, producing H(2)S, and failing to produce catalase or to grow in 10% O(2). Antigens of V. sputorum cross-reacted in low titer with antisera to V. fetus serotypes I, II, III, and V. V. sputorum differed from V. bubulus by being inhibited by 3.5% NaCl and by qualitative differences in growth in the presence of 1% glycine and 10% O(2). These differences do not appear sufficient to recognize two distinct species, and it is proposed that both species be recognized as V. sputorum, which has priority. Strains unable to grow in 3.5% NaCl would be considered V. sputorum var. sputorum, whereas strains capable of growth in 3.5% NaCl would be V. sputorum var. bubulum.
Fast-food and full-service restaurant consumption and daily energy and nutrient intakes in US adults

Fast-food and full-service restaurant consumption and daily energy and nutrient intakes in US adults
Deconstruction's Legal Career

This article describes law's encounter with deconstruction, and how it changed deconstruction. In the hands of lawyers, deconstruction became a set of rhetorical strategies for critiquing legal distinctions and showing their ideological character. Legal scholars used deconstructive arguments to offer normative prescriptions in ways quite different from literary critics or philosophers. Although in theory all texts and distinctions are deconstructable, legal scholars assumed that some interpretations were better than others. Legal deconstruction thus became a set of repeatable rhetorical practices used for pragmatic purposes; and it revealed that these rhetorical and pragmatic features were already present in literary and philosophical deconstruction. Deconstruction's encounter with law also overturned several popular assumptions about deconstruction. First, legal deconstruction does not assert that legal texts have no meaning or that their meanings are indecipherable. Rather, it argues that texts are overflowing with meanings that point in different directions and emerge over time. Second, one deconstructs conceptual oppositions not to show that legal concepts have no boundaries, but that their boundaries are fluid and appear differently as the conceptual opposition is placed into new interpretive contexts. Legal deconstruction asserts that legal distinctions are nested oppositions - conceptual oppositions whose terms bear a relation of mutual dependence and differentiation; this complicated relationship is revealed as interpretive contexts change. Ideological drift, in which concepts change their political valence as they are repeatedly invoked at different points in history, is a special case of this phenomenon. Third, instead of asserting that legal doctrine is radically indeterminate, legal deconstruction suggests that social construction places ideological constraints on legal decisionmaking and helps produce the sense that some arguments are better than others. Finally, far from denying the existence of fundamental human values, legal deconstruction presupposes a transcendent value of justice which law attempts to express but always fails fully to articulate.
Theory of High Energy Hadron-Nucleus Collisions

The last two or three years have seen a considerable revival of the use of real nuclei, ones having A > 1, as targets in high energy collision experiments. That has been, I believe, because of the growing realization that the problem of dealing with nuclei theoretically is not as complicated as we might have imagined. Nuclear physics becomes, at billion volt energies, a very much simpler subject than it is at low energies. A high energy particle passing through a nucleus tends hardly to be deflected at all in its passage and is gone before any nuclear rearrangement it induces can take place. It is so very much more energetic than any nucleon in the nucleus that, for all practical purposes, when it collides with individual nucleons the others are simply stationary spectators.
dBASE III plus and the MARC AMC format: problems and possibilities

As archives with smaller holdings adapt to the MARC AMC data format, they will need to explore the utility of various commercially-available, microprocessorbased, data base management systems. This article presents four approaches to using the AMC format in dBASE III Plus, the best selling of these systems. The discussion of the limitations and possibilities of the four approaches demonstrates that while there is no inherent incompatibility between dBASE and the MARC format, the most efficient use of a dBASE-MARC system requires considerable programming.
Enhancing Retention of Future Information Professionals Using Attitude Inoculation

Amelioration de la Retention des Futurs Professionnels de l’Information avec la Theorie de l’InoculationLes previsions d’emploi dans le domaine des Systemes d’Information (SI) varient au fil du temps, mais les employeurs evoquent souvent le fosse entre les besoins de l’entreprise et le manque de personnes qualifiees sur le marche du travail. Ce constat souleve la question de savoir comment les etudiants prennent leur decision de poursuivre ou non un diplome dans un domaine donne au vu des informations disponibles sur un secteur particulier du marche de l’emploi. L’objectif principal de cet article est de comprendre si et comment des messages d’inoculation pourraient aider les etudiants a maintenir leurs attitudes positives pre-existantes envers les caracteristiques des professions des technologies de l’information; d’explorer les raisons pour lesquelles certains choisissent de poursuivre des etudes dans le domaine des systemes d’information et de suggerer des solutions pour accroitre le nombre de ceux qui choisissent ce domaine professionnel.Ce projet de recherche utilise la Theorie de l’Inoculation. Les hypotheses posees ont ete testees par une experimentation de terrain. La premiere hypothese teste la resistance au changement pour les participants qui recoivent un message d’inoculation avant un message persuasif au sujet du domaine professionnel des systemes d’information. Les deux autres hypotheses testent la resistance au changement sur la base du genre des participants et de leur programme d’etudes.Plusieurs resultats significatifs ont ete mis en evidence. Les groupes qui ont ete inocules ont presente une plus grande resistance au changement. Un declin plus faible de la resistance a ete observe pour les participants du groupe de traitement; les participants des groupes de controle ont ete plus affectes par le message persuasif que les participants qui avaient recu l’inoculation. Toutefois, l’etude n’a pas montre de difference significative basee sur le genre ou le domaine d’etudes. Ces resultats permettent de mieux adapter la communication envers les futurs professionnels de l’information.
Further evaluation of the effects of laminin, testosterone, ganglioside GM 1, and catalase on early growth in rat nerve regeneration chambers.

Abstract We present here the results of an extended series of experiments on the effects of exogenous biochemical agents on nerve regeneration. They were applied by multiple injection into in vivo nerve regeneration chambers developed in this laboratory for rat sciatic nerve. Previously, a mixture of laminin, testosterone, ganglioside GM 1, and catalase at a defined concentration was shown to substantially advance the progress and maturation of regeneration in 16-day chambers, out of a variety of numerous other agents screened. In this study, an attempt is made to further clarify the contribution of the single ingredients used in combination. None of the agents proved to be able to mimick the previously observed effects by themselves (to their full extent). The best results were obtained by application of laminin; catalase treatment revealed results apparently worse than those in controls. Therefore, a redefined combination of the described agents, catalase now being omitted, was also tested. These results appeared to be grossly similar to those we recently reported.
Adenosine, L-AP4, and baclofen modulation of paired-pulse potentiation in the dentate gyrus: interstimulus interval-dependent pharmacology.

Paired-pulse potentiation of the glutamate-mediated excitatory postsynaptic potential (EPSP) recorded in the dentate gyrus molecular layer is thought to be mediated presynaptically. It is known that the activation of adenosine (A1) and GABAB receptors results in the reduction of glutamate release in the dentate molecular layer via presynaptic mechanisms. To examine possible modulatory roles of these receptors on paired-pulse potentiation, we examined the effects of adenosine and baclofen (a GABAB agonist) on paired-pulse potentiation using extracellular recording from the lateral perforant path in rat hippocampal slices maintained in vitro. We compared these effects with those of l-α-amino-4-phosphonobutyric acid (l-AP4) over a wide range of interstimulus intervals (ISIs). l-AP4 enhanced paired-pulse potentiation over the full range of ISIs tested (40–800 ms), whereas adenosine enhanced paired-pulse potentiation only at ISIs of 40–100 ms. In contrast, baclofen reduced paired-pulse potentiation only at ISIs of 400–800 ms. Furthermore, baclofen increased the amplitude of lateral perforant path field potentials, previously reported to be baclofen-insensitive. These results suggest that paired-pulse potentiation can be modulated through the activation of adenosine and baclofen receptors, indicate that this modulation is dependent on ISI, and show that there are at least two pharmacologically separable components of paired-pulse potentiation in the dentate gyrus.
A re-evaluation of curvature-specific chromatic aftereffects

Abstract Prolonged adaptation to red convex and green concave curves results in an aftereffect of the opposite color on test patterns composed of convex and concave arcs. This result has recently been ascribed to the adaptation of curvature detectors in the human visual system; the adaptation of lineorientation detectors, thought to be responsible for the McCollough effect, has been rejected as an explanation. We performed several experiments whose results lead to a different conclusion. The aftereffect was measured by two techniques: a color-naming method, and a cancellation procedure. We find that: (1) When fixation is at the centers of the arcs during both adaptation and testing, the aftereffect is stronger at the edaes of the arcs than at the centers. (2) The color of the aftereffect reverses when the test patterns are fixated beyond the edges of the arcs. (3) No aftereffect is observed, if during adaptation, the obsener moves his eyes perpendicular to the axis through the centers of the arcs. We conclude that these curvaturespecific aftereffects are the result of the adaptation of line-orientation detectors, and not of curvature detectors.