cssi/SciSciGPT-SciSciNet huggingface dataset:
Extramedullary acute myeloid leukemia: leukemic pleural effusion, case report and review of the literature.

Objective and Importance: Malignant pleural effusions occur in the setting of both solid and hematologic malignancies. Pleural effusion caused by leukemic infiltration is an unusual extramedullary manifestation of acute myeloid leukemia (AML) with fewer than 20 cases reported.1-11 We report a case of pericardial and pleural effusions in a patient with AML and review the literature. Clinical presentation: In this case, a 55 year old man with previous history of myeloproliferative neoplasm (MPN) experienced transformation AML, heralded by appearance of leukemic pleural effusions. The patient was identified to have leukemic pleural effusion based upon extended cytogenetic analysis of the pleural fluid, as morphologic analysis alone was insufficient. Intervention: The patient was treated with hypomethylator-based and intensive chemotherapy strategies, both of which maintained resolution of the effusions in the remission setting. Conclusion: Due to the rarity of diagnosis of leukemic pleural effusions, both cytogenetic and fluorescence in situ hybridization (FISH) testing are recommended. Futhermore, systemic chemotherapy directed at the AML can lead to complete resolution of leukemic pleural effusions. Objective and ImportancePleural effusion caused by leukemic infiltration is an unusual extramedullary manifestation of acute myeloid leukemia (AML), but may be more common than previously thought. Fewer than 20 cases have been reported.1-11 We report a case of pericardial and pleural effusions in a patient with AML and review the literature.
Facebook and academic performance: Reconciling a media sensation with data

A recent draft manuscript suggested that Facebook use might be related to lower academic achievement in college and graduate school (Karpinski, 2009). The report quickly became a media sensation and was picked up by hundreds of news outlets in a matter of days. However, the results were based on correlational data in a draft manuscript that had not been published, or even considered for publication. This paper attempts to replicate the results reported in the press release using three data sets: one with a large sample of undergraduate students from the University of Illinois at Chicago, another with a nationally representative cross sectional sample of American 14- to 22-year-olds, as well as a longitudinal panel of American youth aged 14-23. In none of the samples do we find a robust negative relationship between Facebook use and grades. Indeed, if anything, Facebook use is more common among individuals with higher grades. We also examined how changes in academic performance in the nationally representative sample related to Facebook use and found that Facebook users were no different from non-users.
Glycogen phosphorylase in the rat levator ani: activity related to testosterone, epinephrine and actinomycin D.

Active phosphorylase (a) and total phosphorylase (t) were determined in the levator ani muscle of rats 1) after varying periods of castration, 2) after injections of testosterone propionate, actinomycin D and combinations thereof into normal and castrate rats, and 3) after treatment with epinephrine in vitro. All muscles were subjected to in vitro treatment in Krebs-Ringer-bicarbonate medium for no less than 30 min prior to assay to reduce the initially high level of active phosphorylase produced by the stimulation involved in removal of the muscle. No change in phosphorylase a activity (per g muscle wet weight) was observed up to 4 weeks after castration but phosphorylase t activity progressively decreased. In contrast, castration had no effect on phosphorylase activity in the rectus femoris muscle. Testosterone injections, iv, into castrates had no effect on the enzyme within 6 hr; daily injections for 4 days, sc, restored phosphorylase t to normal levels of activity without affecting phosphorylase a. A...
PSYCHOLOGY AMONG THE SCIENCES: COMPARISONS OF NUMBERS OF THEORIES AND LAWS CITED IN TEXTBOOKS

A measure called “theories-to-laws ratio” (number of cited theories divided by number of cited laws in textbooks) was used to assess hypotheses concerning the concept of an “hierarchy of sciences” and psychology's place among the sciences. (1) The ratio will be well-balanced, i.e., show low values, for the “natural” sciences (physics, chemistry, biology) and be poorly balanced, i.e., show high values, for the “social” sciences (anthropology, sociology). (2) The theories-to-laws ratio of psychology will be closer to the mean of the “social” sciences than to the mean of the “natural” sciences. Analysis showed a 67% agreement between the present data and the predicted “hierarchy of sciences” relative ordering of the sciences so Hypotheses 1 and 2 were confirmed. Other quantitative measures, in addition to this ratio, might be developed to evaluate further psychology's place among the sciences.
Value of preoperative prothrombin time/partial thromboplastin time as a predictor of postoperative hemorrhage in pediatric patients undergoing tonsillectomy

OBJECTIVE: Hemorrhage after tonsillectomy is a potentially lethal complication. Preoperative assessment consisting of prothrombin time (PT) and activated partial thromboplastin time (PTT) has been used to identify patients at risk for hemorrhage after tonsillectomy and adenoidectomy. We sought to assess the value of PT/PTT screening as a predictor of posttonsillectomy hemorrhage.DESIGN: A retrospective chart review was carried out with a minimum of 1 month follow-up.SETTING: Tertiary academic referral center.PATIENTS: Between January 1992 and June 1995, 382 patients undergoing tonsillectomy were examined; 339 patients with a minimum of 1 month follow-up were reviewed for this study.MAIN OUTCOME MEASURE: Normal and prolonged PT/PTT values were examined. Bleeding in the intraoperative, immediate postoperative, and delayed phases of healing was examined.RESULTS: Two-hundred and twenty-two patients had normal PT/PTT, 39 had prolonged PT/PTT, and 78 had no preoperative studies performed. Bleeding occurred in 2...
Exploiting symmetry and transactions for partial order reduction of rule based specifications

Rule based specifications are popular for specifying protocols, such as cache coherence protocols specified in TLA+, Murphi, or the BlueSpec language. Specifications in these notations are a collection of unordered rules of the form guard → atomic_updates. There is no notion of a sequential process with local scope or specialized communication channels, and each rule tends to update multiple fields of the global state. It is believed that partial order (PO) reduction, a powerful state space reduction technique, is difficult to achieve in such a setting. Partial order reductions attempt to visit a smaller set of states by selectively exploring a subset of all enabled transitions at each state, based on the independence of transitions. In earlier work, we have reported a suitable algorithm for this purpose, where the independence relation is computed using symbolic analysis and SAT. In this paper, we expand on this algorithm and show how to exploit some commonly seen characteristics of rule based specifications. First, many of these systems have a transactional nature, such as the request/grant transactions of cache coherence protocols. We show how to use this information while picking subsets of transitions at each state. Second, many of these systems are parameterized, and also exhibit symmetry. We show that, for such systems, the SAT-based computation of the independence relation between rules can be performed once and for all in a manner that is accurate for all parameterized instances of the protocol. Third, we show that sharpening the SAT-based independence computation through local invariants can aid PO reduction. Here, we propose a way by which users may guess these invariants: we can check these invariants and the property of interest in one combined phase under PO reduction (we prove that there is no circularity in this process). Our results indicate that with the above measures, rule based systems can have efficient and effective PO reduction algorithms.
Objective and subjective visual performance of multifocal contact lenses: pilot study.

Abstract Purpose The aim of the present study was to compare the objective and subjective visual performance of three different soft multifocal contact lenses. Methods 10 subjects (habitual soft contact lens wearers) between the ages of 40 and 45 years participated in the study. Three different multifocal silicone hydrogel contact lenses (Acuvue Oasys, Air Optix and Biofinity) were fit within the same visit. All the lenses were fit according to the manufacturers’ recommendation using the respective fitting guide. Visual performance tests included low and high contrast distance and near visual acuity, contrast sensitivity, range of clear vision and through-focus curve. Objective visual performance tests included measurement of open field accommodative response at different defocus levels and optical aberrations at different viewing distances. Results Accommodative response was not significantly different between the three types of multifocal contact lenses at each of the accommodative stimulus levels (p > 0.05). Accommodative lag increased for higher stimulus levels for all 3 types of contact lenses. Ocular aberrations were not significantly different between these 3 contact lens designs at each of the different viewing distances (p > 0.05). In addition, optical aberrations did not significantly differ between different viewing distances for any of these lenses (p > 0.05). ANOVA revealed no significant difference in high and low contrast distance visual acuity as well as near visual acuity and contrast sensitivity function between the 3 multifocal contact lenses and spectacles (p > 0.05). Conclusions There was no statistically significant difference in accommodative response, optical aberrations or visual performance between the 3 multifocal contact lenses in early presbyopes.
5-HT stimulation of heart rate in Drosophila does not act through cAMP as revealed by pharmacogenetics

The fruit fly, Drosophila melanogaster, is a good experimental organism to study the underlying mechanism of heart rate (HR) regulation. It is already known that many neuromodulators (serotonin, dopamine, octopamine, acetylcholine) change the HR in Drosophila melanogaster larvae. In this study, we investigated the role of cAMP-PKA signaling pathway in HR regulation and 5-HT positive chronotropic action. In order to obtain insight into the 5-HT mechanism of action in larvae cardiomyocytes, genetic and pharmacological approaches were used. We used transgenic flies that expressed the hM4Di receptor [designer receptors exclusively activated by designer drugs (DREADDs)] as one tool. Our previous results showed that activation of hM4Di receptors (modified muscarinic acetylcholine receptors) decreases or arrests the heart from beating. In this study, it was hypothesized that the positive chronotropic effect of serotonin [5-hydroxytryptamine (5-HT)] are mediated by serotonin receptors coupled to the adenylyl cyclase pathway and downstream cAMP and PKA activity. Activation of hM4Di by clozapine-N-oxide (CNO) was predicted to block the effects of serotonin by inhibiting adenylyl cyclase activity through Gαi pathway activation. Interestingly, we found here that manipulation of adenylyl cyclase activity and cAMP levels had no significant effect on HR. The ability of hM4Di receptor activation to slow or stop the heart is therefore likely mediated by activation of GIRK channels to produce hyperpolarization of cardiomyocytes, and not through inhibition of adenylyl cyclase.
Time course of endothelial-neutrophil interaction in splanchnic artery ischemia-reperfusion.

Splanchnic artery occlusion and reperfusion (SAO/R) results in a severe form of circulatory shock that has a high mortality rate. To examine the time course of the early events involved in SAO/R, o...
Role of glucocorticoids in the maturation of renal cortical Na+-K+-ATPase during fetal life in sheep.

Glucocorticoid levels increase greatly at the time of birth in humans and sheep, coinciding with an increased ability of the kidney to reabsorb sodium. Cortisol induces proximal tubule apical membr...
Towards Stealthy Malware Detection

Malcode can be easily hidden in document files and go undetected by standard technology. We demonstrate this opportunity of stealthy malcode insertion in several experiments using a standard COTS Anti-Virus (AV) scanner. Furthermore, in the case of zero-day malicious exploit code, signature- based AV scanners would fail to detect such malcode even if the scanner knew where to look. We propose the use of statistical binary content analysis of files in order to detect suspicious anomalous file segments that may suggest insertion of malcode. Experiments are performed to determine whether the approach of n-gram analysis may provide useful evidence of a tainted file that would subsequently be subjected to further scmtiny. We further perform tests to determine whether known malcode can be easily distinguished from otherwise “normal” Windows executables, and whether self-encrypted files may be easy to spot. Our goal is to develop an efficient means by static content analysis of detecting suspect infected files. This approach may have value for scanning a large store of collected information, such as a database of shared documents. The preliminary experiments suggest the problem is quite hard requiring new research to detect stealthy malcode.
Hourly and Seasonal Collections of Six Harmful Insects in Traps Equipped with Black light Lamps

Curves showing the hourly and seasonal catches in traps equipped with black light lamps are given for 6 species of North Carolina insect pests: the army worm, Pseudaletia unipuncta (Haworth); the yellow-striped army worm, Prodenia ornithogalli Guenee; the black cutworm, Agrotis ipsilon (Hufnagel); the grape leaf skeletonizer, Harrisina americana (Guerin-Meneville); the yellow woollybear, Diacrisia virginica (F.); and the European corn borer, Ostrinia nubilalis (Hubner).
Effects of Fungicide Sprays During Apple Bloom on Pollen Viability and Honey Bee Foraging

Fungicide applications were made during apple, Malus domestica Borkch., bloom to determine the duration of fungicide effects on pollen viability in the field and whether spray applications affect the foraging behavior of honey bees. Apis mellifera L. Fungicide sprays did not affect the numbers of honey bees foraging on trees or their foraging behavior. Mean percent pollen germination was depressed to levels between 12.2 and 31.1% by captan and to 29.5% by Dikar 2 h after spray application. Recovery of pollen viability required 24 to 48 h, depending upon orchard conditions. Benlate, Polyram, Baycor, and Topsin-M had no significant effect on pollen viability. The rapid recovery of pollen viability after initial spray applications and the lack of effect on flower visitation by bees indicate minimal effects on pollination or fruit set under most conditions.
Nutritive factors in plant tissues. V. Further observations on the occurrence of vitamin-B

In the course of our studies of the distribution of vitamins in plant products we have collected data regarding a number of important edible foods for which no information in this respect seems to be available at present, with the possible exception of indirect suggestions obtained by other than animal feeding trials. Our experiments, made with rats, supplement numerous earlier ones1 conducted by the same technique and indicate that asparagus, celery, dandelion, lettuce, and parsley all contain noteworthy amounts of vitamin-B. The details of the investigation will be published elsewhere.
Developmental exposure to 2,3,7,8-tetrachlorodibenzo-p-dioxin may alter LH release patterns by abolishing sex differences in GABA/glutamate cell number and modifying the transcriptome of the male anteroventral periventricular nucleus

Developmental exposure to arylhydrocarbon receptor (AhR) ligands abolishes sex differences in a wide range of neural structures and functions. A well-studied example is the anteroventral periventricular nucleus (AVPV), a structure that controls sex-specific luteinizing hormone (LH) release. In the male, testosterone (T) secreted by the developing testes defeminizes LH release mechanisms; conversely, perinatal AhR activation by 2,3,7,8,-tetrachlorodibenzo-p-dioxin (TCDD) blocks defeminization. To better understand developmental mechanisms altered by TCDD exposure, we first verified that neonatal TCDD exposure in male rats prevented the loss of AVPV GABA/glutamate neurons that are critical for female-typical LH surge release. We then used whole genome arrays and quantitative real-time polymerase chain reaction (QPCR) to compare AVPV transcriptomes of males treated neonatally with TCDD or vehicle. Our bioinformatics analyses showed that TCDD enriched gene sets important for neuron development, synaptic transmission, ion homeostasis, and cholesterol biosynthesis. In addition, upstream regulatory analysis suggests that both estrogen receptors (ER) and androgen receptors (AR) regulate genes targeted by TCDD. Of the 23 mRNAs found to be changed by TCDD at least 2-fold (p<0.05), most participate in the functions identified in our bioinformatics analyses. Several, including matrix metallopeptidase 9 and SRY-box 11 (Sox11), are known targets of E2. CUG triplet repeat, RNA binding protein 2 (cugbp2) is particularly interesting because it is sex-specific, oppositely regulated by estradiol (E2) and TCDD. Moreover, it regulates the post-transcriptional processing of molecules previously linked to sexual differentiation of the brain. These findings provide new insights into how TCDD may interfere with defeminization of LH release patterns.
Does Marital Status Impact Outcomes After Total Knee Arthroplasty

Abstract Background There is a paucity of research on the relationship between marital status and patient outcomes following total knee arthroplasty (TKA). Methods This was a retrospective chart review of patients who underwent TKA by a single surgeon at a university-based orthopedic practice. Data abstracted included age, gender, marital status, body mass index, length of hospital stay, the Western Ontario and McMaster Universities Osteoarthritis Index (WOMAC), and Oxford Knee Score (OKS). The WOMAC and OKS were administered at the preoperative visit and at approximately 10, 30, 90, and 180 days after TKA. Multivariate analyses with patient-reported outcomes as repeated measures, marital status, day of assessment; and the interaction of marital status and day of assessment as fixed effects; and age, gender, body mass index, and length of hospital stay as covariates were conducted as well as analyses in which preoperative patient-reported outcomes were treated as fixed effects. Results Of 422 patients who underwent TKA during the study period, complete data were available for 249, of whom 124 were married and 125 unmarried. Married patients had significantly higher WOMAC scores than unmarried patients at all postoperative assessments, even after controlling for preoperative scores. Although married patients also had significantly higher postoperative OKS scores than their unmarried peers, differences between groups were attenuated after adjusting for preoperative OKS scores. Conclusion This study found that married patients have better overall outcomes after TKA but yielded conflicting results as to whether the positive effects of marriage are specific to the postoperative period.
Positive end-expiratory pressure (PEEP) ventilation for liver transplant patients: the evolving story.

Objective: Evaluation of the impact of end-expiratory pressure (PEEP) ventilation on venous liver outflow, portal vein, and hepatic artery flows as well as systemic hemodynamics in patients following liver transplantation (LT). Design: Prospective, interventional patient study. Setting: University hospital intensive care unit. Patients: 65 consecutive patients after LT. Interventions: All patients were intubated and mechanically ventilated with biphasic positive airway pressure (BIPAP). The effects of three levels of PEEP (0, 5, and 10 mbar) applied at random order on hepatic inflow and outflow were studied in the immediate postoperative period. Measurement and results: Central venous-, arterial pressure, and cardiac index was recorded from every patient at three different PEEP levels (0, 5, and 10 mbar). Simultaneously, flow velocities in the hepatic-, portal vein, and hepatic artery were determined by Doppler ultrasound. PEEP of 10 mbar significantly increased central venous pressure in comparison with zero PEEP. Mean arterial pressure and cardiac index was not influenced. Hepatic inflow and outflow of the transplanted livers were not impaired by any of the used PEEP levels. Conclusions: BIPAP ventilation with PEEP levels up to 10 mbar does not affect systemic hemodynamics. Furthermore, neither venous outflow nor portal venous or hepatic artery inflow of the liver are impaired at PEEP levels up to 10 mbar immediately following liver transplantation. Although these results suggest that PEEP ventilation up to 10 mbar does not affect liver hemodynamics, further studies are needed to determine whether these findings could be confirmed for a longer ventilation period with PEEP.
Exploring multiple feature spaces for novel entity discovery

Continuously discovering novel entities in news and Web data is important for Knowledge Base (KB) maintenance. One of the key challenges is to decide whether an entity mention refers to an in-KB or out-of-KB entity. We propose a principled approach that learns a novel entity classifier by modeling mention and entity representation into multiple feature spaces, including contextual, topical, lexical, neural embedding and query spaces. Different from most previous studies that address novel entity discovery as a submodule of entity linking systems, our model is more a generalized approach and can be applied as a pre-filtering step of novel entities for any entity linking systems. Experiments on three real-world datasets show that our method significantly outperforms existing methods on identifying novel entities.
A suggestion for a data structure for temporal GIS

A new data structure for the implementation of temporal geographic information systems is presented. This data structure, based on Kantabutra's ILE database management system, treats both time and place as first-class citizens and utilizes direct linkages among entities that are related to each other. The suggested data structure supports naturally the three types of queries suggested by Peuquet as queries that a temporal GIS database should be able to answer.
An Iterative Image Enhancement Procedure With Dynamic Range Constraints

An extension to image processing of Van Cittert's iterative restoration technique for one-dimensional data is presented. A particular advantage of the algorithm given here is the ability to satisfy amplitude constraints. It is useful for presentation of high-dynamic-range imagery in a limited display environment. Preliminary pictorial experiments are promising. Implementation aspects of the technique are further discussed.© (1980) COPYRIGHT SPIE--The International Society for Optical Engineering. Downloading of the abstract is permitted for personal use only.
The role of sense of community in brand online social networking

This study is designed to examine the role of a sense of community in brand online social networking (BOSN). In particular, this study explores the sense of community model from community psychology in the context of social media marketing (e.g., Facebook), and several antecedents are examined. The data was collected based on an online self-administered survey (n = 466) and analysed with the structural equation modelling to test the measurement model and suggested hypotheses. The results demonstrate that perceived social support and overall self-brand connection as a predictor of building a sense of online brand community, which, in turn, leads to an increase in brand commitment. Consumers' engagement in the brand community is found to strengthen the relationship between one's sense of community and brand commitment. Findings from this study are expected to contribute to the extant literature of brand community by highlighting the relational nature of online brand social network.
A LONG-TERM PERSPECTIVE

The thirteen preceding papers in this volume were presented at the Seventeenth International Tsunami Symposium held by the International Union of Geodesy and Geophysics (IUGG) Tsunami Commission in July 1995 in Boulder, Colorado. The Symposium was part of the XXI General Assembly of the IUGG and was sponsored in part by the International Association of Seismology and the Physics of the Earth’s Interior (IASPEI) and in part by the Union.
TGFβ Regulates EMT in Head and Neck Cancer

The epithelial-mesenchymal transition (EMT) has been a major focus of cancer research for many years, in part because of the association it has with metastasis and disease progression. In recent years, EMT has also been linked to increased cancer stem cell populations. The transforming growth factor-beta (TGFβ) pathway induces EMT in many cancer types, including head and neck cancer. There are several important transcription factors essential to TGFβ-induced EMT, including Snail and Twist. Additionally, several deregulated microRNAs contribute to the oncogenic process by influencing translation of these transcription factors. In this chapter, we will discuss the contribution of the TGFβ pathway, the transcription factors Snail and Twist, and the microRNAs involved in regulating EMT and cancer stem cell populations in head and neck cancer.
Synthesis of dihydronaphthalene analogues inspired by combretastatin A-4 and their biological evaluation as anticancer agents

The natural products colchicine and combretastatin A-4 (CA4) have provided inspiration for the discovery and development of a wide array of derivatives and analogues that inhibit tubulin polymerization through a binding interaction at the colchicine site on β-tubulin. A water-soluble phosphate prodrug salt of CA4 (referred to as CA4P) has demonstrated the ability to selectively damage tumor-associated vasculature and ushered in a new class of developmental anticancer agents known as vascular disrupting agents (VDAs). Through a long-term program of structure activity relationship (SAR) driven inquiry, we discovered that the dihydronaphthalene molecular scaffold provided access to small-molecule inhibitors of tubulin polymerization. In particular, a dihydronaphthalene analogue bearing a pendant trimethoxy aryl ring (referred to as KGP03) and a similar aroyl ring (referred to as KGP413) were potent inhibitors of tubulin polymerization (IC50 = 1.0 and 1.2 μM, respectively) and displayed low nM cytotoxicity against human cancer cell lines. In order to enhance water-solubility for in vivo evaluation, the corresponding phosphate prodrug salts (KGP04 and KGP152, respectively) were synthesized. In a preliminary in vivo study in a SCID-BALB/c mouse model bearing the human breast tumor MDA-MB-231-luc, a 99% reduction in signal was observed with bioluminescence imaging (BLI) 4 h after IP administration of KGP152 (200 mg kg−1) indicating reduced tumor blood flow. In a separate study, disruption of tumor-associated blood flow in a Fischer rat bearing an A549-luc human lung tumor was observed by color Doppler ultrasound following administration of KGP04 (15 mg kg−1).
Exposure to Neighborhood Crime Is Associated with Lower Levels of Physical Activity and Higher Obesity Risk among Adolescent Girls, but Not Boys.

Abstract Background: Neighborhood safety has been linked to physical activity and obesity among adolescents, but few studies have used objective measures of crime or examined associations by gender...
Black Litigants in the Antebellum American South. By Kimberly M. Welch. (Chapel Hill, NC: University of North Carolina Press, 2018. Pp. xiv, 306. $39.95.)

Scholars of southern courts have long emphasized their regulation of black lives and curtailment of rights, yet, as Kimberly M. Welch argues, these narratives obscure recognition of blacks as activ...
Strategic antecedents of innovation: Variance between small and large firms

Our study explores differences in enhancing innovation based on firm size. Framed through the resource-based view, we theorize and test antecedents of innovation including dynamic capabilities, str...
Arteriovenous Malformations: Radiation Therapy

Radiation therapy has been a technique used to treat arteriovenous malformations (AVMs) starting back in the 1920’s with the use of ionizing radiation by Dr. Harvey Cushing and Dr. Bailey. There are many forms of radiation therapy that have undergone investigation for their effectiveness in treatment of AVMs, including precision delivery in the form of radiosurgery. This chapter will discuss each form of radiation, the current understanding of their use, and their effect on long-term outcomes in the treatment of AVMs.
Synthesis of vicinal diamines from cyclic sulfates

Abstract Necleopila opining of cyclic sulfates with secondary amaturs followed by treatment with base leads to elimination of sulfate and formation of an aziridinium ion This can in turn be opened by a second equivalent of the amine to yield a vicinal dianune or by a second nucleophile to give an α- functionalized amine
Enabling On-the-Fly Hardware Tracing of Data Reads in Multicores

Software debugging is one of the most challenging aspects of embedded system development due to growing hardware and software complexity, limited visibility of system components, and tightening time-to-market. To find software bugs faster, developers often rely on on-chip trace modules with large buffers to capture program execution traces with minimum interference with program execution. However, the high volumes of trace data and the high cost of trace modules limit the visibility into the system operation to short program segments. This article introduces a new hardware/software technique for capturing and filtering read data value traces in multicores that enables a complete reconstruction of parallel program execution. The proposed technique exploits tracking of data reads in data caches and cache coherence protocol states to minimize the number of trace messages streamed out of the target platform to the software debugger. The effectiveness of the proposed technique is determined by analyzing the required trace port bandwidth and trace buffer sizes as a function of the data cache size and the number of processor cores. The results show that the proposed technique significantly reduces the required trace port bandwidth, from 12.2 to 73.9 times, when compared to the Nexus-like read data value tracing, thus enabling continuous on-the-fly data tracing at modest hardware cost.
Development and evaluation of Alzheimer’s Disease and Related Dementias (ADRD) best care practices in long-term care online training program

We developed online training modules focused on Alzheimer’s disease and related dementias (ADRD) designed to improve best care practices in long-term care settings, such as nursing homes, as a part...
The impact of sarcopenia on transplant-related complications and number of days spent in the hospital in patients with lymphoma.

7044 Background: Sarcopenia, a state of abnormally low muscle mass, has been found to be associated with more treatment-related complications and shorter overall survival in patients with different...
Advanced cancer patients' (CP) attitudes and perceptions regarding reasons for outpatient supportive care (SC) referral at a comprehensive cancer center: A randomized controlled study.

e24135Background: Current ASCO guidelines propose early access to SC in all CP to improve quality of care, quality of life, and symptoms. Very few studies have evaluated patients’ perceived criteri...
Evaluation of the Use of a Diabetes Risk Test to Identify Prediabetes in an Employee Wellness Screening.

Background:The American Diabetes Association (ADA) Diabetes Risk Test (DRT) is a screening tool to identify people at risk for developing diabetes. Individuals with a DRT score of 5 or higher may h...
MEDITATIONS ON STRATHCLYDE: CONTROLLING PRIVATE LAND USE RESTRICTIONS AT THE CROSSROADS OF LEGAL SYSTEMS

This article presents a comparative study of a pivotal case decided by the Lands Tribunal of Scotland, Strathclyde Joint Police Board v. The Elderslie Estates Ltd. The decision exemplifies how Scotland, one of the world's leading mixed jurisdictions, addresses several fundamental property law issues. Should landowners be allowed to impose restrictions on the use of land that bind future owners in perpetuity? Should courts have any power to modify or terminate those land use restrictions if the passage of time appears to undermine their initial purpose and utility? Does the application of the European Convention on Human Rights change how a court must protect fundamental property rights? This comparative case study sheds light on how Scotland has answered all these questions, reflects on the costs and benefits of its solutions, and contrasts the Scottish approach with typical approaches under American law. The Lands Tribunal's decision, the article also argues, demonstrates a powerful communitarian conception of property in Scottish law, one that has continued to surface even after the formal abolition of Scottish feudalism in 2004 and that differs substantially from the market based conception of property reigning in the United States today.
An FPGA-Based Upper-Limb Rehabilitation Device for Gesture Recognition and Motion Evaluation Using Multi-Task Recurrent Neural Networks

This work presents a mobile FPGA-smart rehabilitation system that can be used at home. The prototype is a rehabilitation table instrumented with a capacitive sensor array (CSA) to track the upper-extremity motions of the user through proximity or touch. In addition, inertial measurement units (IMUs) are placed on the affected upper limb and combined with the CSA data with our sensor fusion signal processing architecture. Motions are classified and evaluated using multi-task convolutional recurrent neural networks. The prototype achieves real-time execution time with above 99% accuracy using 32-bit fixed-point format implementation for simultaneously recognizing dynamic motions and identifying unnatural characteristics in upper limb motions based on sensor values. The C-LSTMlC-GRU fusion classification network is implemented on a 200 MHz Zynq ZCU104 FPGA using an HLS-based design optimized with pipelining and parallelism techniques.
Modeling lattice rotation fields from discrete crystallographic slip bands in superalloys

Abstract In this work, we investigate the relationship between an intense slip band (ISB) and the zone of large lattice rotations that forms ahead of the tip of the ISB. We develop a crystal plasticity finite element model of a discrete ISB lying within an oligocrystalline assembly and calculate the local crystalline stress and lattice rotation fields generated by the ISB. The calculations demonstrate that, first, a region of severe lattice rotations, commonly referred to as a microvolume, does not form without the ISB, and second, large amounts of accumulated slip in the ISB are required to enlarge the microvolume to sizes and rotation magnitudes observed experimentally. Ahead of the ISB tip, the quintessential plastic zone always forms, but the atypical microvolume forms when non-concentrated and spatially diffuse slip is activated by the ISB-induced stress field. This result suggests that the detrimental ISB/microvolume pair will likely appear in pairs of crystals in which transmission of the slip from the ISB is severely blocked by the grain boundary, a hypothesis that we verify with a few target cases.
Local Field Statistic and Plasmon Localization in Random Metal-Dielectric Films

A new, exact and efficient numerical method for calculating the effective conductivity and local-field distributions in random R-L-C networks is developed. Using this method, the local field properties of random metal dielectric films are investigated in a wide spectral range and for a variety of metal concentrations p. It is shown that for metal concentrations close to the percolation threshold (p = p c) and frequencies close to the resonance, the local field intensity is characterized by a non-Gaussian, exponentially broad distribution. For low and high metal concentrations a scaling region is formed that is due to the increasing number of non-interacting dipoles. The local electric fields are studied in terms of characteristic length parameters. Properties of both localized and extended eigenmodes in the Kirchhoff’s Hamiltonian are investigated.
Variational Approach to Self-Adjointness

In this chapter we introduce a methodological tool of central relevance for our analysis, the conditions of variational self-adjointness, which will later result to be necessary and sufficient conditions for the existence of a Lagrangian or Hamiltonian (Chapter 3).
A pilot functional MRI study of the effects of prefrontal rTMS on pain perception.

Objective. Repetitive transcranial magnetic stimulation (rTMS) has been shown to effectively treat depression, and its potential value in pain management is emphasized by recent studies. Transcranial magnetic stimulation (TMS)-evoked activity in the prefrontal cortex may be associated with corticolimbic inhibitory circuits capable of decreasing pain perception. The present exploratory pilot study used functional magnetic resonance imaging (fMRI) to examine the effects of left prefrontal rTMS on brain activity and pain perception. Design and Intervention. Twenty-three healthy adults with no history of depression or chronic pain underwent an 8-minute thermal pain protocol with fMRI before and after a single rTMS session. Participants received 15 minutes of either real (N = 12) or sham (N = 11) 10 Hz rTMS over the left prefrontal cortex (110% of resting motor threshold; 5 seconds on, 10 seconds off). Results. TMS was associated with a 13.30% decrease in pain ratings, while sham was associated with an 8.61% decrease (P = 0.04). TMS was uniquely associated with increased activity in the posterior cingulate gyrus, precuneous, right superior frontal gyrus, right insula, and bilateral postcentral gyrus. Activity in the right superior prefrontal gyrus was negatively correlated with pain ratings (r = −0.65, P = 0.02) in the real TMS group. Conclusions. Findings suggest that prefrontal rTMS may be capable of activating inhibitory circuits involved with pain reduction.
Genes for two herbicide-inducible cytochromes P-450 from Streptomyces griseolus.

Abstract Streptomyces griseolus ATCC 11796 contains two inducible, herbicide-metabolizing cytochromes P-450 previously designated P-450SU1 and P-450SU2 (P-450CVA1 and P-450CVB1, respectively, using nomenclature of Nebert et al. [D. W. Nebert, M. Adesnik, M. J. Coon, R. W. Estabrook, F. J. Gonzalez, F. P. Guengerich, I. C. Gunsalus, E. F. Johnson, B. Kemper, W. Levin, I. R. Phillips, R. Sato, and M. R. Waterman, DNA 6:1-11, 1987]). Using antibodies directed against cytochrome P-450SU1, its N-terminal amino acid sequence, and amino acid composition, we cloned the suaC gene encoding cytochrome P-450SU1. Similar information about the cytochrome P-450SU2 protein confirmed that a gene cloned by cross-hybridization to the suaC gene was the subC gene encoding cytochrome P-450SU2. The suaC and subC genes were expressed in Escherichia coli, DNA for both genes was sequenced, and the deduced amino acid sequences were compared with that of the well-characterized cytochrome P-450CAM from Pseudomonas putida. Both cytochromes P-450SU1 and P-450SU2 contain several regions of strong similarity with the amino acid sequence of P-450CAM, primarily in regions of the protein responsible for attachment and coordination of the heme prosthetic group.
VisionBlocks: A Social Computer Vision Framework

Vision Blocks (http://visionblocks.org) is an on demand, in-browser, customizable computer vision application publishing platform for masses. It empowers end-users (consumers)to create novel solutions for themselves that they would not easily obtain off-the-shelf. By transferring design capability to the consumers, we enable creation and dissemination of custom products and algorithms. We adapt a visual programming paradigm to codify vision algorithms for general use. As a proof of-concept, we implement computer vision algorithms such as motion tracking, face detection, change detection and others. We demonstrate their applications on real-time video. Our studies show that end users (non programmers) only need 50%more time to build such systems when compared to the most experienced researchers. We made progress towards closing the gap between researchers and consumers by finding that users rate the intuitiveness of the approach in a level 6% less than researchers. We discuss different application scenarios where such study will be useful and argue its benefit for computer vision research community. We believe that enabling users with ability to create application will be first step towards creating social computer vision applications and platform.
The Complementary Role of Tort Litigation in Regulating the Gun Industry

Tort claims against gun manufacturers call on judges to make policy choices about firearm design and marketing. There is much debate over whether judges should be in the business of making policy choices. On one hand, traditionalists denounce judicial policy making as violating the constitutional separation of powers which reserves policy making to legislatures and consigns courts to resolving individual disputes between parties. Moreover, according to this view, courts lack the breadth of perspective necessary to make good public policy, a breadth that legislatures achieve through initiating investigations or holding hearings. In addition, courts of general jurisdiction lack the technical and scientific expertise that administrative agencies lend to legislative policy making. On the other hand, progressives embrace judicial policy making as part of a public law vision of the tort system. According to this view, courts should craft creative solutions to social problems when deadlocked or corrupt legislatures fail to act. Furthermore, by using procedural techniques that allow for the consolidation of many claims into one legal proceeding, courts can resolve individual claims en masse, thereby avoiding the possible inconsistencies and inefficiencies of piecemeal adjudication on a case-by-case basis. In this chapter, I advocate an intermediate position. I argue that courts should play a secondary role in policy making that complements the regulatory efforts of legislatures and administrative agencies. Against the traditionalist position, I assert that judges are wise in attending to the public policy implications of their rulings in individual cases. The nature of common law adjudication is to apply old legal principles to new problems. The proper application of these principles, however, is often unclear, and judges are required to resolve ambiguities on the basis of something other than clear precedent. It is here that policy analysis plays a legitimate role in judging. Against the progressive position, I argue that courts should confine their policy analysis to the resolution of doctrinal ambiguities. Courts should use policy analysis to gradually refine tort law's system of rules for resolving private disputes in ways that serve the public interest. Radical shifts in doctrine, even when supported by sound policy choices, undermine the legal stability that in our constitutional scheme courts are uniquely qualified to protect. Furthermore, I argue that in making policy choices, courts should, where possible, follow the lead of legislatures. To the extent that there are discernable trends in legislative consideration of a problem, it undermines the legitimacy of judicial decision making for judges to contradict them. The danger of unrestrained judicial policy making is greatest in mass torts, where the aggregation of claims and industry-wide liability exposure can easily transform the resolution of private disputes into the crafting of innovative solutions to social problems, without due regard for doctrinal integrity or legislative preferences.
Transabdominal Fundoplication (Nissen)

Reflux esophagitis without good response to medical therapy, whether or not an anatomical hiatus hernia is present. If a previous operation has been performed at the esophagogastric junction for reflux, a transthoracic or thoracoabdominal approach is preferred. Stein and DeMeester summarize their indications for an antireflux operation as follows: 1) Persistent or recurrent symptoms and/or complications after 8 to 12 weeks of intensive acid suppression therapy, and 2) Increased esophageal exposure to gastric juice on 24 hour esophageal pH monitoring, and 3) Documentation of a mechanically defective lower esophageal sphincter on manometry.
Application of symbolic algebra to the generation of coordinate transformations

Abstract In this paper we present tools for automatic generation of generalized (variable and terrain-following) coordinate transformations and its use in numerical models of atmospheric flows. Such methodology should be competitive with the more commonly employed nested grid schemes. We discuss the symbolic (computer) algebra program for analytical calculation of Christoffel symbols, metric tensor and other geometrical objects describing a transformation. An example, related to the numerical modeling of mesoscale flows, is given. This example shows how coupled terrain-following and stretching transformation can be easily created. The possible application of such methodology in numerical modeling of air pollution on cirrus clouds is briefly discussed.
A refined theorem concerning the conditioning of semidefinite programs

Using a weaker version of the Newton-Kantorovich theorem [6] given by us in [3], we show how to refine the results given in [8] dealing with the analyzing of the effect of small perturbations in problem data on the solution. The new results are obtained under weaker hypotheses and the same computational cost as in [8].
Russia on the Way to a Housing Market: A Case Study of St Petersburg:

The Russian government has launched a privatization program with the aim of creating a housing market in place of administrative allocation. Very few, including reformers at the top level of government, realize the economic, social, and political value of housing reforms. At this stage, their goals are very narrow: to free the state of its construction and maintenance burden, and to collect revenues from real-estate owners to support the activities of local governments. These reforms yield little, if anything, given cumbersome and contradictory private-ownership laws, power squabbles between interest groups at different levels of the local and federal governments, and resistance at the grass roots. For the above reasons any market-oriented policies although effective in the countries of the ex-socialist block, may be impossible in Russia. Thus, in St Petersburg, the second largest Russian city, a short-lived privatization program collapsed in early 1993. In this urban community, as in a microcosm, the int...