cssi/SciSciGPT-SciSciNet huggingface dataset:
Firm Characteristics and Expected Stock Returns

We develop new methods for constructing and analyzing cross-sectional stock return forecasts. We propose an E-LASSO approach that uses the LASSO, forecast combination, and forecast encompassing to implement shrinkage in a flexible manner designed to handle a large number of firm characteristics. We provide a cross-sectional out-of-sample R-squared statistic for assessing the accuracy of cross-sectional forecasts. Empirically, with presently the largest set of 193 firm characteristics, we find that our E-LASSO forecast produces significant cross-sectional out-of-sample R-squared gains and generates substantial economic value consistently over time. We further find that many firm characteristics matter, instead of a dozen or so.
Man vs machine: Are febrile neutropenia rates different using an in-clinic vs on-body injection?

e18867Background: The granulocyte-colony stimulating factor pegfilgrastim can either be administered as an injection in clinic or as an on-body (Onpro) injection that delivers a standard dose 27 ho...
Impact of strain, sex, and estrous cycle on gamma butyrolactone-evoked absence seizures in rats.

Abstract Childhood absence epilepsy (CAE) is the most common pediatric epilepsy syndrome and is characterized by typical absence seizures (AS). AS are non-convulsive epileptic seizures characterized by a sudden loss of awareness and bilaterally generalized synchronous 2.5–4 Hz spike and slow-wave discharges (SWD). Gamma butyrolactone (GBL) is an acute pharmacological model of AS and induces bilaterally synchronous SWDs and behavioral arrest. Despite the long use of this model, little is known about its strain and sex-dependent features. We compared the dose-response profile of GBL-evoked SWDs in three rat strains (Long Evans, Sprague-Dawley, and Wistar), and examined the modulatory effects of estrous cycle on SWDs in female Wistar rats. We evaluated the number of seizures, the cumulative time seizing, and the average seizure duration as a function of dose, strain, and sex/estrous phase. Long Evans rats displayed the greatest sensitivity to GBL, followed by Wistar rats, and then by Sprague-Dawley rats. GBL-evoked SWDs were modulated by estrous cycle in female rats, with the lowest sensitivity to GBL occurring during metestrus. Wistar rats showed the greatest variability as a function of dose, and the least variability within dose; these features make this strain desirable for interventional studies. Moreover, our finding that the SWD response to GBL differs as a function of estrous cycle underscores the importance of cycle monitoring in studies examining female animals using this model. Together, these strain and sex-dependent findings provide guidance for future studies.
Reconstruction and Recovery After Massive Burn.

Background Forty years ago, a 33-year-old female suffered a 35% total body surface area burn after the car in which she was a passenger caught fire in a rear-end collision. She experienced second- and third-degree burns of her face, head, back, arms, and hands. Methods After immediate burn resuscitation, the patient underwent approximately 40 reconstructive procedures over the course of the first 17 years after her burns. Results While finding social situations difficult to endure, the patient developed tools to help her face the public. Conclusions These tools included confident body language, verbal responses, and makeup application. This case report details surgical procedures the patient underwent and her own lasting contribution through establishing the first hospital-based Image Enhancement and Behavioral Skills program along with her extensive work with the Phoenix Society for Burn Survivors.
Shell model extension to the valence force field: application to single-layer black phosphorus.

We propose an extension of the traditional valence force field model to allow for the effect of electronic polarization to be included in the inter-atomic potential. Using density functional theory as a reference, this model is parameterized for the specific case of single-layer black phosphorus by fitting the phonon dispersion relation over the entire Brillouin zone. The model is designed to account for the effect of induced dipole interaction on the long-wavelength (|| → 0) modes for the case of homopolar covalent crystals. We demonstrate that the near Γ-point frequencies of the IR-active modes are substantially damped by the inclusion of the induced dipole interaction, in agreement with experiment. The fitting procedure outlined here allows for this model to be adapted to other materials, including but not limited to two-dimensional crystals.
Epilepsy education in gliomas: engaging patients and caregivers to improve care

Tumor-related epilepsy (TRE) is the most common cause of hospitalizations in patients with malignant gliomas leading to increased distress and decreased quality of life (QOL) for patients and caregivers. We sought to determine the feasibility of incorporating a structured TRE-specific education intervention into clinical practice while assessing effect on distress and TRE knowledge. We prospectively enrolled glioma patients and their caregivers on an IRB-approved study. Subjects underwent a pre-test to assess baseline knowledge regarding seizure management. A neuro-oncology provider guided subjects through a presentation focused on safety and home management of seizures. Seizure-related distress was measured before and after the educational intervention using a distress thermometer. A post-test was completed. At 2 and 6 months, distress was re-assessed and post-tests were repeated. Subject satisfaction was assessed. Fifty subjects (23 patients, 27 caregivers) were enrolled. Median age was 59. Fifty-seven percent of patients had TRE. Median time to completion was 21.5 min. Median baseline distress scores were 2/10 for patients and 5/10 for caregivers. Distress scores decreased by a mean of 1.5 points and TRE knowledge increased by 2 points for all subjects between the initial and 2-month visit. Ninety-eight percent of subjects strongly agreed that the education was helpful and informative. Caregivers reported more distress despite better baseline seizure knowledge than patients. Structured TRE education is feasible in patients with gliomas and their caregivers and may be effective in reducing distress. Further prospective studies are warranted to assess effects on hospitalizations, cost, and QOL.
Evaluation of fungicides and biocontrol products for the control of Phytophthora root rot of hydrangeas

Phytophthora root rot is one of the most important diseases in almost all hydrangeas of nursery production. In this study, the efficacy of fungicides and biocontrol products against Phytophthora ro...
Reduction of invasive interventions in severely obese with osteoarthritis after bariatric surgery

Osteoarthritis (OA) affects 56,000,000 Americans, 30% with obesity. Their risk of developing OA is 5 times higher. With each extra kilogram above ideal weight, the risk of OA increases to 13%. The study aim is to describe changes in OA treatment after undergoing bariatric surgery (BS). After IRB approval, we conducted a retrospective analysis of all severely obese patients and OA that underwent laparoscopic adjustable gastric banding, laparoscopic sleeve gastrectomy (LSG), and laparoscopic Roux-en-Y gastric bypass from 2004 to 2018. Changes of OA severity were assessed based on the requirement of invasive intervention (INI) at 12 and 24 months after BS. INI was defined as the need for surgical drainage; articular injection; and surgical interventions such as meniscectomy, total hip replacement, and total knee replacement. A total of 11.52% (N = 486) had OA diagnosed prior to BS, the most common location being unilateral hip 31.1% (N = 151). A total of 35.2% (N = 159) of patients required pain management (PM) for OA at 12 months. Of these, 90% (N = 144) required only INI and 5.6% (N = 9) required PM only. Baseline and postoperative BMI were associated to need for INI. At 12 months, the 66.7% (N = 301) who did not require INI had a baseline BMI of 44.70 ± 8.22 and total weight loss percent (TWL%) of 14.29 ± 13 (P = 0.05; 95% CI 0.96–1.00). LSG patients were the majority compared to other procedures (44.5%; N = 134). On the other hand, 64.3% (N = 175) did not require INI at 24 months and had a baseline BMI of 17.82±17.4 and TWL% of 2.43 ± 6 (P = 0.003; 95% CI 1.04–1.25). The risk to require INI was reduced by 69.9% at 12 months and 80% at 24 months. Need for pain medications at 12 months was reduced by 96.9%. According to this study data, bariatric surgery reduces the need for INI in patients with OA. The effect seems to be related to the amount of weight loss. Additional studies conducted on a larger scale are necessary to validate findings.
Spin-torque switching of noncollinear antiferromagnetic antiperovskites

Antiferromagnetic (AFM) spintronics exploits the N\'eel vector as a state variable for novel electronic devices. Recent studies have demonstrated that the N\'eel vector can be switched by a spin-orbit torque. These studies however are largely limited to collinear antiferromagnets of proper magnetic space-group symmetry. There is, however, a large group of high-temperature noncollinear antiferromagnets, which are suitable for such switching. Here, we predict that spin torque can be efficiently used to switch a noncollinear AFM order in antiperovskite materials. Based on first-principles calculations and atomistic spin-dynamics modeling, we show that in antiperovskites $A\mathrm{NM}{\mathrm{n}}_{3}$ ($A=\mathrm{Ga}$, Ni, etc.) with the AFM ${\mathrm{\ensuremath{\Gamma}}}_{4\mathrm{g}}$ ground state, the AFM order can be switched on the picosecond timescale using a spin torque generated by a spin current. The threshold switching current density can be tuned by the $A\mathrm{NM}{\mathrm{n}}_{3}$ stoichiometry engineering, changing the magnetocrystalline anisotropy. The ${\mathrm{\ensuremath{\Gamma}}}_{4\mathrm{g}}$ AFM phase supports a sizable anomalous Hall effect, which can be used to detect the spin-torque switching of the AFM order. The predicted ultrafast switching dynamics and the efficient detection of the AFM order state make noncollinear magnetic antiperovskites a promising material platform for AFM spintronics.
The Dynamics of Intimate Relationships and Contraceptive Use During Early Emerging Adulthood

We investigate the immediate social context of contraceptive behaviors: specifically, the intimate relationship. We use the Relationship Dynamics and Social Life (RDSL) study (2008-2012), based on a random sample of 1,003 women ages 18-19 residing in a Michigan county. Women were interviewed weekly for 2.5 years, resulting in an age range of 18-22. We test three sets of hypotheses about change over time within a relationship, using relationship-level within-between models, which compare a couple's contraceptive behaviors across different times in the relationship. First, we find that a couple is less likely to use contraception when the relationship is more intimate and/or committed and that a couple becomes less likely to use contraception over time, regardless of intimacy and commitment. Second, we find that a couple using contraception becomes increasingly likely to choose hormonal over coital methods, but this change occurs as a relationship endures and is unrelated to intimacy and/or commitment. Third, we find that a condom-using couple's consistency does not decline when there is conflict; rather, consistency of condom use declines over time regardless of the relationship's characteristics. We also demonstrate that conflict and power imbalance increase reliance on hormonal methods among those using contraception; conflict decreases consistency among withdrawal (but not condom) users; and nonmonogamy increases reliance on condoms and decreases withdrawal consistency. The strong and consistent link between duration and contraceptive behaviors-regardless of intimacy, commitment, conflict, or power imbalance-suggests that the continual vigilance required for long-term contraceptive use is difficult during early emerging adulthood.
Breast Cancer Skip Metastases: Frequency, Associated Tumor Characteristics, and Role of Staging Nodal Ultrasound in Detection.

Please see the Editorial Comment by Mary S. Newell discussing this article. BACKGROUND. Staging nodal ultrasound (US) evaluates locations beyond those assessed during routine surgical dissection an...
Intracranial vascular feature changes in time of flight MR angiography in patients undergoing carotid revascularization surgery

Abstract Purpose To characterize the intracranial vascular features extracted from time of flight (TOF) images and their changes from baseline to follow-up in patients undergoing carotid revascularization, using arterial spin labeling (ASL) cerebral blood flow (CBF) measurement as a reference. Methods In this retrospective study, brain TOF and ASL images of 99 subjects, acquired before, within 48 h, and/or 6 months after, carotid revascularization surgery were analyzed. TOF images were analyzed using a custom software (iCafe) to quantify intracranial vascular features, including total vessel length, total vessel volume, and number of branches. Mean whole-brain CBF was calculated from ASL images. ASL scans showing low ASL signal in the entire flow territory of an internal carotid artery (ICA), which may be caused by labeling failure, were excluded. Changes and correlations between time points were analyzed separately for TOF intracranial vascular features and ASL CBF. Results Similar to ASL CBF, TOF vascular features (i.e. total vessel length, total vessel volume and number of branches) increased dramatically from baseline to post-surgery, then returned to a level slightly higher than the baseline in long-term follow-up (All P Conclusion Intracranial vascular features, including total vessel length, total vessel volume and number of branches, extracted from TOF images are useful in detecting brain blood flow changes induced by carotid revascularization surgery.
Symptom provocation during aerobic and dynamic supervised exercise challenges in adolescents with sport-related concussion

Context Supervised exercise challenges (SECs) have been shown to be safe and beneficial in the early symptomatic period after concussion. Thus far, most in-clinic SECs studied have included a form of basic aerobic exercise only. An SEC that also includes dynamic forms of exercise mimics all steps of a standard return-to-play progression and may enhance the detection of concussion symptoms to guide in-clinic management decisions. Objective To determine whether an SEC that includes a dynamic SEC (DSEC) uncovered symptoms that would not have been identified by an SEC involving an aerobic SEC (ASEC) alone in adolescent patients with sport-related concussion. Design Retrospective case series. Setting Multidisciplinary sport concussion clinic at a tertiary care center. Patients or other participants A total of 65 adolescent athletes (mean age = 14.9 ± 2.0 years, 72.3% males) who underwent an in-clinic SEC within 30 days of concussion. Main outcome measure(s) Presence of pre-exercise symptoms and symptom provocation during the SEC were recorded, with exercise-provoked symptoms categorized as occurring during ASEC or DSEC. Results Of the total patient sample, 69.2% (n = 45/65) experienced symptom provocation at some point during the SEC. Symptoms were provoked in 20 patients during the ASEC, whereas 25 completed the ASEC without symptom provocation before becoming symptomatic during the subsequent DSEC and 20 completed the SEC without any symptom provocation. Of the 65 patients in the total sample, 46 were asymptomatic immediately before the SEC. Of these previously asymptomatic patients, 23.9% (n = 11/46) experienced symptom provocation during the ASEC, and an additional 37.0% (n = 17/46) remained asymptomatic during the ASEC but then developed symptoms during the DSEC. Conclusions The ASEC alone may not detect symptom provocation in a significant proportion of concussion patients who otherwise would develop symptoms during a DSEC.
Electroencephalography, Hospital Complications, and Longitudinal Outcomes After Subarachnoid Hemorrhage.

Following non-traumatic subarachnoid hemorrhage (SAH), in-hospital delayed cerebral ischemia is predicted by two chief events on continuous EEG (cEEG): new or worsening epileptiform abnormalities (EAs) and deterioration of cEEG background frequencies. We evaluated the association between longitudinal outcomes and these cEEG biomarkers. We additionally evaluated the association between longitudinal outcomes and other in-hospital complications. Patients with nontraumatic SAH undergoing ≥ 3 days of cEEG monitoring were enrolled in a prospective study evaluating longitudinal outcomes. Modified Rankin Scale (mRS) was assessed at discharge, and at 3- and 6-month follow-up time points. Adjusting for baseline severity in a cumulative proportional odds model, we modeled the mRS ordinally and measured the association between mRS and two forms of in-hospital cEEG deterioration: (1) cEEG evidence of new or worsening epileptiform abnormalities and (2) cEEG evidence of new background deterioration. We compared the magnitude of these associations at each time point with the association between mRS and other in-hospital complications: (1) delayed cerebral ischemia (DCI), (2) hospital-acquired infections (HAI), and (3) hydrocephalus. In a secondary analysis, we employed a linear mixed effects model to examine the association of mRS over time (dichotomized as 0–3 vs. 4–6) with both biomarkers of cEEG deterioration and with other in-hospital complications. In total, 175 mRS assessments were performed in 59 patients. New or worsening EAs developed in 23 (39%) patients, and new background deterioration developed in 24 (41%). Among cEEG biomarkers, new or worsening EAs were independently associated with mRS at discharge, 3, and 6 months, respectively (adjusted cumulative proportional odds 4.99, 95% CI 1.60–15.6; 3.28, 95% CI 1.14–9.5; and 2.71, 95% CI 0.95–7.76), but cEEG background deterioration lacked an association. Among hospital complications, DCI was associated with discharge, 3-, and 6-month outcomes (adjusted cumulative proportional odds 4.75, 95% CI 1.64–13.8; 3.4; 95% CI 1.24–9.01; and 2.45, 95% CI 0.94–6.6), but HAI and hydrocephalus lacked an association. The mixed effects model demonstrated that these associations were sustained over longitudinal assessments without an interaction with time. Although new or worsening EAs and cEEG background deterioration have both been shown to predict DCI, only new or worsening EAs are associated with a sustained impairment in functional outcome. This novel finding raises the potential for identifying therapeutic targets that may also influence outcomes.
Finding Order in the Chaos: Outstanding questions in Klebsiella pneumoniae pathogenesis.

Klebsiella pneumoniae are Gram-negative facultative anaerobes that are found within host-associated commensal microbiomes, but they can also cause a wide range of infections that are often difficult to treat. These infections are caused by different pathotypes of K. pneumoniae, called either classical or hypervirulent strains. These two groups are genetically distinct, inhabit nonoverlapping geographies, and cause different types of harmful infections in humans. These distinct bacterial groups have also been found to interact differently with the host immune system. Initial innate immune defenses against K. pneumoniae infection include complement, macrophages, neutrophils, and monocytes; these defenses are primary strategies employed by the host to clear infections. K. pneumoniae pathogenesis depends upon the interactions between the microbe and each of these host defenses, and it is becoming increasingly apparent that bacterial genetic diversity impacts the outcomes of these interactions. Here, we highlight recent advances in our understanding of K. pneumoniae pathogenesis, with a focus on how bacterial evolution and diversity impact K. pneumoniae interactions with mammalian innate immune host defenses. We also discuss outstanding questions regarding how K. pneumoniae can frustrate normal immune responses, capitalize upon states of immunocompromise, and cause infections with high mortality.
cytoNet: Spatiotemporal Network Analysis of Cell Communities

Abstract We introduce cytoNet, a cloud-based tool to characterize cell populations from microscopy images. cytoNet quantifies spatial topology and functional relationships in cell communities using principles of network science. Capturing multicellular dynamics through graph features, cytoNet also evaluates the effect of cell-cell interactions on individual cell phenotypes. We demonstrate cytoNet’s capabilities in four case studies: 1) characterizing the temporal dynamics of neural progenitor cell communities during neural differentiation, 2) identifying communities of pain-sensing neurons in vivo, 3) capturing the effect of cell community on endothelial cell morphology, and 4) investigating the effect of laminin α4 on perivascular niches in adipose tissue. The analytical framework introduced here can be used to study the dynamics of complex cell communities in a quantitative manner, leading to a deeper understanding of environmental effects on cellular behavior. The versatile, cloud-based format of cytoNet makes the image analysis framework accessible to researchers across domains. Availability and Implementation QutubLab.org/how | cytoNet contact: cytoNetProject@gmail.com Brain Initiative Alliance Toolmaker cytoNet site: https://www.braininitiative.org/toolmakers/resources/cytonet/ Author / Lay Summary cytoNet provides an online tool to rapidly characterize relationships between objects within images and video frames. To study complex tissue, cell and subcellular topologies, cytoNet integrates vision science with the mathematical technique of graph theory. This allows the method to simultaneously identify environmental effects on single cells and on network topology. cytoNet has versatile use across neuroscience, stem cell biology and regenerative medicine. cytoNet applications described in this study include: (1) characterizing how sensing pain alters neural circuit activity, (2) quantifying how vascular cells respond to neurotrophic stimuli overexpressed in the brain after injury or exercise, (3) delineating features of fat tissue that may confer resistance to obesity and (4) uncovering structure-function relationships of human stem cells as they transform into neurons.
Eco-friendly additive manufacturing of metals: Energy efficiency and life cycle analysis

Abstract Additive manufacturing (AM) of metal materials has attracted widespread attention and is shifting the conventional manufacturing landscape toward free-form processes. With increasing concerns about global sustainability, eco-consideration is highly encouraged to be integrated into AM processes. This review provides a comprehensive and timely discussion on the life cycle of metal parts fabricated through AM. The energy consumption required for raw metal material extraction and subsequent AM processes is analyzed. The eco-design and energy efficiency of metal AM are evaluated to reveal the role of manufacturing methods, machine subsystems, and post-processing modes in the eco-integration. AM-induced supply chain management, utilization, and recycling of the printed metal structure are also analyzed. Finally, a comprehensive life cycle assessment regarding the environmental, social, and economic impacts of metal AM is also addressed. Future directions of AM are also briefly discussed to provide insight and vision on the emerging field of additive eco-manufacturing.
Wavelet Transform Artificial Intelligence Algorithm-Based Data Mining Technology for Norovirus Monitoring and Early Warning.

Norovirus monitoring and early warning can be used for diagnosis without etiological testing, and the treatment of this disease does not require the antibiotics. It often occurs in preschool children and affects their growth and development, so the coping measures for this disease are more prevention than treatment. In this study, the clinical data of 2133 children with diarrhea were collected. Based on the artificial intelligence (AI) algorithm of wavelet transform, a related model for data mining and processing of children’s intestinal ultrasound images and stool specimens was constructed. Then, the norovirus infection trend was warned based on the wavelet analysis algorithm model. The results showed that the intestinal ultrasound image processed by the wavelet transform algorithm was clearer. The positive detection rate of norovirus in children with clinical diarrhea was as high as 59%, and the children had different degrees of body damage, of which the probability of compensatory metabolic acidosis was the highest. The epidemiological analysis found that children with norovirus infection were mainly concentrated in the age group under 2 years old and over 5 years old and showed a peak of infection in December. In summary, the intelligent algorithm based on wavelet transform can realize the noise reduction of intestinal ultrasound, and it should protect children with susceptible age and susceptible seasons to reduce the clinical infection rate of norovirus.
Main and Moderating Influence of Temperament Traits on the Association Between Intimate Partner Violence and Trauma Symptoms

Trauma symptoms are common among survivors of intimate partner violence (IPV), although not all women who experience IPV develop trauma symptoms. One of the factors that may influence whether women develop trauma symptoms upon exposure to IPV is temperament. In this study, we examined the main and moderating effects of temperament traits (constraint, negative emotionality, and positive emotionality) on the association between IPV and trauma symptoms in a sample of young adult women ( N = 654) using a Bayesian approach to multiple linear regression to address significant non-normality in the data. Our results indicated that each temperament trait incrementally predicted trauma symptoms over and above the effects of IPV and other negative life events. Results further indicated that both negative emotionality and constraint moderated the influence of IPV on trauma symptoms such that IPV was positively associated with trauma symptoms at high levels of these traits but not at low levels. However, these effects differed depending on the type of violence experienced (physical, sexual, or psychological). These results extend previous research on the influence of temperament traits to the context of IPV; this underscores the importance of incorporating temperament in the study of IPV, as well as in the study of traumatic stress more generally.
Traumatic Aortic Insufficiency in Children: Case Report and Review of the Literature

Aortic valve regurgitation and saccular aneurysm of the ascending aorta developed in a 5-year-old boy following severe compressive injury to the chest. While rare, traumatic aortic valve disruption may lead to serious cardiac dysfunction. Recognition of acute aortic insufficiency and other forms of cardiac damage requires special attention in patients with nonpenetrating chest injury.
Time-resolved intrinsic fluorescence of enzyme I.: The monomer / dimer transition

Enzyme I of the bacterial phosphotransferase system can exist in a monomer/dimer equilibrium which may have functional significance. Each monomer contains two tryptophan residues. It is demonstrated that the decay of both the monomer and the dimer can be described by a biexponential. The decay times depend on the temperature and at 6 degrees C the decay times are tau 1 = 0.4 ns and tau 2 = 3.2 ns for the monomer and tau 3 = 3.2 ns and tau 4 = 7.2 ns for the dimer form of the enzyme. The changes in the fluorescence decay parameters can be utilized to measure the equilibrium constant for the monomer/dimer transition.
Integration of clinical and genetic data in the i2b2 architecture

The Informatics for Integrating Biology and the Bedside (i2b2) is one of the sponsored initiatives of the NIH Roadmap National Centers for Biomedical Computing (http://www.bisti.nih.gov/ncbc/). One of the goals of i2b2 is to provide clinical investigators broadly with the software tools necessary to collect and manage project-related clinical research data in the genomics age as a cohesive entity - a software suite to construct and manage the modern clinical research chart.
Detection of posteriorly located breast tumors using gold nanoparticles: a breast-mimicking phantom study.

BACKGROUND: Accurately depicting breast tumors located posteriorly, close to the chest wall musculature, with conventional mammography is a technical challenge. OBJECTIVE: This study demonstrates the proof of concept of an x-ray fluorescence mapping (XFM) technique to address this issue. METHODS: A tissue-equivalent gel phantom is designed to mimic structures in the central part of a compressed breast. The posterior aspect of the breast and adjacent pectoralis major muscle are represented by another 10-mm-thickness breast tissue simulation phantom (BR12) that is attached to the back of the gel phantom as a region of interest (ROI). Two gold nanoparticle (GNP) solutions are embedded into the ROI to simulate varying GNP uptake within breast lesions. The ROI is imaged through performing the XFM technique with an x-ray pencil-beam and a single spectrometer. RESULTS: A 2D mapping of the middle plane in the ROI demonstrates feasibility and matches well the known spatial distribution and different GNP concentrations. 3D reconstruction of the ROI is easily rendered by repeating the 2D mapping process. CONCLUSION: XFM system geometry and its insensitivity to attenuation coefficients of breast tissue components are unique characteristics that may complement conventional mammography and improve the detection of breast cancers located posteriorly, adjacent to or overlying the chest wall musculature.
Studies on the Mode of Action of Chemical Carcinogens in Cultured Mammalian Cells

Researchers estimate that environmental chemicals are responsible for a portion of human cancers. These chemicals, identified as potential carcinogens by epidemiology or experimental studies, constitute a very diverse group and thus are likely to interact in the carcinogenic process at different stages and to varying degrees.
Structure, expression, and some regulatory mechanisms of the rat preprotachykinin gene encoding substance P, neurokinin A, neuropeptide K, and neuropeptide gamma

The rat preprotachykinin (PPT) gene encoding the neuropeptides substance P (SP), neurokinin A (NKA), neuropeptide K (NPK), and neuropeptide gamma was isolated from a lambda Charon 4A genomic library. Two overlapping clones contained all of the exons present in beta-PPT, including some 7 and 9 kb 5' and 3' flanking sequence, respectively. The presence of 1 major and 2 minor transcription initiation sites was determined from primer extension and nuclease protection experiments. Analysis of the nucleotide sequence homology between the rat and bovine revealed the presence of highly conserved regions throughout the entire coding region and within the 5' flanking sequences. Primer extension and nuclease protection experiments demonstrated that the primary transcript is differentially spliced primarily into gamma- and beta-PPT mRNA in all tissues examined in the adult rat where the gene is expressed. beta-PPT mRNA contains all of the exons, whereas gamma-PPT mRNA lacks exon 4, which encodes part of the N-terminus of NPK. The alpha-PPT mRNA, which lacks exon 6 (the sequence encoding NKA and processing sites), comprises about 1% of the total PPT mRNA. An RNA secondary structure model is proposed to account for these specific exon exclusion events in the RNA splicing process. These results are discussed with regard to the mechanisms regulating SP gene expression and the functional significance of differential RNA splicing in the rat.
Multiple instruction stream control for an associative model of parallel computation

This paper describes a system software design for multiple instruction stream control in a massively parallel associative computing environment. The purpose of providing multiple instruction stream control is to increase throughput and reduce the amount of parallel slackness inherent in single instruction stream parallel programming constructs. The multiple associative computing (MASC) model is used to describe this technique and a brief introduction to the MASC model of parallel computation is presented. A simple parallel computing example is used to illustrate the techniques for multiple instruction stream control in a massively parallel runtime environment.
Characterization of a Small Proteolytic Enzyme Which Lyses Bacterial Cell Walls

Ensign, J. C. (University of Wisconsin, Madison), and R. S. Wolfe. Characterization of a small proteolytic enzyme which lyses bacterial cell walls. J. Bacteriol. 91:524–534. 1966.—An enzyme isolated from a myxobacter possesses both cell-wall lytic and proteolytic activity. The enzyme has been purified over 600-fold and is electrophoretically homogeneous upon cellulose acetate at several pH values and upon polyacrylamide gel columns. A single peak was obtained upon ultracentrifugation and density gradient centrifugation. Based upon Sephadex gel filtration, a molecular weight of 8,700 was determined for the enzyme. Albumin and casein were extensively degraded by the enzyme, with approximately one-third of the peptide bonds present in these proteins being hydrolyzed. The enzyme lyses cell walls by hydrolyzing peptide bonds in the glycosaminopeptide. Images
Analysis of Factors that Influence Kernel Weight of Wheat Infected by Septoria nodorum

Several methods for determining yield reduction resulting from Septoria nodorum blotch have appeared in the literature during the past decade. These methods varied from the measurement of effects of disease on components of yield to calculation of area of symptoms on certain leaves at different growth stages. We analyzed data from a uniform group of wheat entries in the USDA Septoria nursery that had been grown in seven locations in North America and Europe during the years 1982–1987. Symptom severity and height of symptom on the plant were compared to kernel number and kernel weight. Location, year-within-location and genotype were also considered. In the context of this study, we concluded that location, and year-within-location are the most important factors determining yield reduction (as measured by relative kernel weight). Selection directly for components of yield is quite effective, but selection by means of disease symptoms is often not correlated with yield. We also conclude that specific methods for relating symptoms to yield reduction that are applicable to a particular location are probably useful and appropriate for that location only.
Assessing the Organizational Social Context (OSC) of child welfare systems: implications for research and practice

OBJECTIVE: The study: (1) provides the first assessment of the a priori measurement model and psychometric properties of the Organizational Social Context (OSC) measurement system in a US nationwide probability sample of child welfare systems; (2) illustrates the use of the OSC in constructing norm-based organizational culture and climate profiles for child welfare systems; and (3) estimates the association of child welfare system-level organizational culture and climate profiles with individual caseworker-level job satisfaction and organizational commitment. METHODS: The study applies confirmatory factor analysis (CFA) and hierarchical linear models (HLM) analysis to a US nationwide sample of 1,740 caseworkers from 81 child welfare systems participating in the second National Survey of Child and Adolescent Wellbeing (NSCAW II). The participating child welfare systems were selected using a national probability procedure reflecting the number of children served by child welfare systems nationwide. RESULTS: The a priori OSC measurement model is confirmed in this nationwide sample of child welfare systems. In addition, caseworker responses to the OSC scales generate acceptable to high scale reliabilities, moderate to high within-system agreement, and significant between-system differences. Caseworkers in the child welfare systems with the best organizational culture and climate profiles report higher levels of job satisfaction and organizational commitment. Organizational climates characterized by high engagement and functionality, and organizational cultures characterized by low rigidity are associated with the most positive work attitudes. CONCLUSIONS: The OSC is the first valid and reliable measure of organizational culture and climate with US national norms for child welfare systems. The OSC provides a useful measure of Organizational Social Context for child welfare service improvement and implementation research efforts which include a focus on child welfare system culture and climate. Language: en
Lorentz Invariance in Reggeization of Pion Photoproduction Amplitudes

We study the implications of Lorentz and gauge invariance for Reggeization of the pion trajectory in charged pion photoproduction and find that the pion need not be introduced as a kinematical singularity. As a consequence of having a dynamical Regge pion pole, we find that effects characteristic of an $s$-channel nucleon pole appear automatically.
You Can't Get There from Here: Children's Understanding of Time-Leaps on Television.

This study examines children's understanding of temporal order as depicted on television through three distinctive techniques — canonical sequencing (normal time), reversed sequencing, and “time‐leaps”; (advanced time). Findings suggest that cognitive skills associated with the ability to comprehend liquid conservation contribute to children's understanding of the temporal ordering of televised events in real time, including both canonical and reversed sequencing. Understanding of the more complex, telegeneric time‐leap modification of temporal sequencing was found to be associated with the quantity of children's television consumption.
Macroeconomic Forces and Mutual Fund Betas

This paper develops and tests a model in which fund betas are linearly related to changes in macroeconomic factors. Tests using monthly returns for 171 mutual funds over 1978–1991 were run. Results indicate that equity funds betas, on average, are negatively related to inflation changes and default risk premia while bond fund betas, on average, are negatively related to changes in risk-free rates, industrial production growth, and the term structure. Betas for passive portfolios, however, are not related to the macroeconomic factors examined.
Toxicities of Cadmium, Copper, and Zinc to Four Juvenile Stages of Chinook Salmon and Steelhead

Abstract Continuous-flow toxicity tests were conducted to determine the relative tolerances of newly hatched alevins, swim-up alevins, parr, and smolts of chinook salmon (Oncorhynchus tshawytscha) and steelhead (Salmo gairdneri) to cadmium, copper, and zinc. Newly hatched alevins were much more tolerant to cadmium and, to a lesser extent, to zinc than were later juvenile forms. However, the later progression from swim-up alevin, through parr, to smolt was accompanied by a slight increase in metal tolerance. The 96-h LC50 values for all four life stages ranged from 1.0 to >27 μg Cd/liter, 17 to 38 μg Cu/liter, and 93 to 815 μg Zn/liter. Steelhead were consistently more sensitive to these metals than were chinook salmon. When a sensitive life stage for acute toxicity tests with metals is sought, the more resistant newly hatched alevins should be avoided. Although tolerance may increase with age, all later juvenile life stages are more sensitive and should give similar results.
Gauge invariant three boson vertices in the Standard Model and the static properties of the W

We use the [ital S]-matrix pinch technique to derive to one-loop order gauge-independent [gamma][ital W][sup +][ital W[minus]] and [ital ZW][sup +][ital W[minus]] vertices in the context of the standard model, with all three incoming momenta off shell. We show that the [gamma][ital W][sup +][ital W[minus]] vertex so constructed is related to the gauge-independent [ital W] self-energy, derived by Degrassi and Sirlin, by a very simple QED-like Ward identity. The same results are obtained by the pinch technique applied directly to the process [ital e][sup +][ital e[minus]][r arrow][ital W][sup +][ital W[minus]]. Explicit calculations give rise to expressions for static properties of the [ital W] gauge bosons such as the magnetic dipole and electric quadrupole moments, which satisfy the crucial properties of infrared finiteness as well as gauge independence.
Synthesis of hazard-free control circuits from asynchronous finite state machines specifications

We discuss a special class of state machine specifications called Asynchronous Finite State Machines (AFSM) which allows the specification and synthesis of hazard-free control circuits under the unbounded delay model. AFSM are useful for the specification of sequential behavior involving choices. In contrast, models such Signal Transition Graphs (STGs) are more amenable to the specification of deterministic concurrent behavior. AFSM specifications are transformed into STGs and then to State Graphs (SGs). At the SG level of representation, hazards can be identified as a type of violations of the Complete State Coding (CSC) property. Algorithms for obtaining SGs from AFSMs, and conditions for hazard-free implementation of SG derived from AFSM are discussed. A hazard-free synthesis technique from SG is described. A CAD prototype called CLASS (Cirrus Logic Asynchronous Synthesis System) has been built and used to successfully synthesize and verify the state machine benchmark from HP Laboroatories [1] and various other real applications.
Paradoxical Blood Concentrating Effect of Intravenous Four Normal Plasma Injections

Conclusions(1) The intravenous injection of concentrated glucose solution causes an immediate blood dilution. This dilution is greater than would be expected if the vascular tree were a closed system. (2) The intravenous injection of concentrated dog and human plasma under similar conditions not only causes no dilution, but a paradoxical blood concentration.
Irreversible thermodynamics of nonlocal systems

Abstract Global laws of balance of momentum, moment of momentum and energy, together with local conservation of mass are reduced to point statements involving localization residuals. A fundamental functional inequality is then obtained which reduces to the Clausius-Duhem inequality for local theories. For nonlocal theories, the functional inequality states that the total internal production of heat of a material body at any given time is non-negative. This inequality is reformulated in terms of a functional inequality on a Hilbert space of ordered collections of L 2 functions. The general solution of this functional inequality is obtained and this leads to all admissible constitutive relations. The existence of dissipation potentials and symmetry relations are established for material bodies with admissible constitutive relations. Nonlocal analogues of Maxwell's reciprocity relations are also obtained as well as a proof of consistency with the results of thermostatics. Satisfaction of nonlinear forms of Onsager's reciprocity relations are shown to be equivalent to the requirement that the operators generating the admissible constitutive relations be potential operators. It is also shown the certain functionals of curves in a function space are odd under time reversal if and only if the nonlinear form of Onsager's reciprocity relations are satisfied. Thus, Gurtin's results [10] for processes which may be approximated by linear departures from equilibrium are extended to all processes with admissible constitutive relations. Similar results are established for significantly less restrictive sets of histories than those used by Gurtin and for a wide class of generalizations of the time reversal operator on such histories. Indications are given that satisfaction of invariance under superimposed rigid body motions implies satisfaction of the zero mean conditions for all localization residuals.
Outcomes after an excisional procedure for cervical intraepithelial neoplasia in HIV-infected women

Objective To determine predictors of treatment failure and recurrence after surgical excisional procedures for CIN in HIV-infected women.
Male responsiveness to infant distress calls in free-ranging vervet monkeys

Playback experiments were conducted of five groups of free-ranging vervet monkeys (Cercopithecus aethiops) to determine whether an adult male's responsiveness to infant distress calls was a function of (1) paternal certainty, (2) dominance rank, (3) predator presence, (4) number of males, (5) number of infants, (6) infant's mother's rank and/or (7) infant's age. Results from these experiments reveal that paternal certainty was the only factor that could directly explain the differences between males in the duration of response to distress calls.
Relationship between coupling and the controllability Grammian in co-design problems

Optimization of smart products requires optimizing the design of both the artifact and its controller. The existence of coupling between these problems currently cannot be established until they are solved. If coupling is expected to be present, then the problem is often solved as a simultaneous optimization. In this paper, it is shown that in several classical control problem formulations the presence of coupling can be established a priori by evaluating derivatives of the controllability Grammian. The concepts developed are demonstrated on a simple positioning gantry example.
Can legality verification rescue global forest governance?: Analyzing the potential of public and private policy intersection to ameliorate forest challenges in Southeast Asia

Abstract One of the most important and pressing questions of our times is to understand better what types of governance arrangements at the local, domestic and international levels, as well as innovative non-state market driven mechanisms that might best address fundamentally important but seemingly intractable environmental, economic and social challenges. This paper sheds light on these questions by assessing the emergence of legality verification as a means to address global forest degradation. Legality verification is puzzling because it presents a relatively modest solution compared to previous efforts to build a legally binding global forest convention, global certification systems or domestic focused “good forest governance” initiatives, and yet it is garnering the interest of wide ranging and diverse global coalitions within developed and developing countries. Does the relatively limited scope of legality verification represent a “race to the bottom” in global forest regulation that many scholars assert is inevitable with the rise of economic globalization? Or, does legality verification trigger the beginning of a process that may provide institutional solutions to global forest governance in ways that previous efforts have yet to accomplish? The purpose of this paper is to offer a theoretical framework with which to guide future research on these questions. To accomplish this task we distinguish conceptually legality verification from global certification and domestic good forest governance initiatives. We then review current support in developed and developing countries, focusing our lens on coalitions supporting legality verification in the United States, European Union, and Southeast Asia. Third, inductively from this review, and deductively, we develop propositions to guide further conceptual and empirical researches focusing on the institutionalization “logics” of legality verification to become an authoritative arena of global forest governance, as well as its potential to reinforce, rather than detract from, global certification and good forest governance initiatives.