cssi/SciSciGPT-SciSciNet huggingface dataset:
Granulocytic sarcoma of the anterior mediastinum.

ABSTRACT Granulocytic sarcoma, or chloroma, rarely occurs in the anterior mediastinum, When it does, the clinical picture may resemble lymphoma. We report two patients in whom evaluation for mediastinal mass revealed the diagnosis of granulocytic sarcoma. In both patients, careful histopathologic evaluation with the aid of special stains confirmed the granulocytic origin of these tumors.
Investigation of a wood treatment facility: Impact on an aquatic ecosystem in the San Joaquin River, Stockton, California

Polychlorinated dibenzo-p-dioxins (PCDDs), polychlorinated dibenzofurans (PCDFs), polychlorinated biphenyls (PCBs), and metals were monitored in the river sediments near the McCormick and Baxter (MCB) wood treatment facility, Stockton, CA. Transplanted clams and resident fish species were used to assess bioavailability. The highest PCDD and PCDF contamination in sediments were confined to an area next to the facility and an area in the nearby Stockton harbor (DK location). Pentachlorophenol (PCP) wood treatment at MCB was the most probable source of the contamination. PCBs contaminated a wider area of the Stockton Ship Channel and harbor. Metal concentrations were uniformly low except for the metalloid arsenic in the Old Mormon Slough and lead and zinc near boat docks in the Stockton harbor. Despite high mortality rates, clams (Corbicula fluminea) bioaccumulated PCBs, PCDDs, and PCDFs. In clams, PCBs and 2,3,7,8 TCDD were much closer to equilibrium with the sediments than were higher chlorinated PCDDs and PCDFs. All fish were at background levels for 2,3,7,8 TCDD. All fish had lower lipid adjusted PCDD/F and PCB concentrations in the skinned muscle than in the whole fish. PCBs in fish were above background levels for United States river systems. Although high contamination exists in the river near this superfund site, adverse effects on the aquatic community could not be demonstrated.
The effects of drone age, semen storage and contamination on semen quality in the honey bee (Apis mellifera)

. The effect of semen storage time, drone age and semen contamination on honey bee semen quality was investigated using assays for motility and viability of semen in vitro. Four age groups (1, 2, 4 and 6 weeks) and five storage times (0, 1, 2, 4 and 6 weeks) were examined. As storage time increased, sperm viability and motility significantly decreased. However, motility patterns of unstored semen samples were significantly lower than those samples that were stored up to 2 weeks. Sperm viability decreased significantly with increasing drone age, but motility patterns did not change. Those semen samples that were found to be contaminated with foreign particles or microorganisms had a significantly lower mean viability than uncontaminated samples.
Structure and dynamic stereochemistry of a five-coordinate spiroarsorane

Abstract The geometry about arsenic in 2,2,3,3,7,7,8,8-octamethyl-5-pheny-1,4,6,9- tetraoxa-5arsasptro[4,4]nonane has been determined by X-ray diffraction as distorted square pyramidal, leading to a revised interpretation of the NMR spectra of this compound.
Doppler spread analysis of human motions for Body Area Network applications

Many current and future medical devices are wearable and the human body is used as a carrier for wireless communication, which implies that the human body is a crucial part of the transmission medium in Body Area Networks (BANs). In order to understand the propagation characteristics of the human body, it is imperative to analyze the Doppler spread spectrum, which is caused by human body motions. Using a network analyzer, Doppler spreads and coherence time of temporal variations caused by human body motions can be measured and analyzed using a single tone waveform for different scenarios in a shielded room. From the narrowband measurement results, the Doppler spread varies approximately from 0.6Hz to 12Hz for different scenarios, the RMS Doppler bandwidth is in the range from 0.6Hz to 4Hz, and the coherence time differs from 20ms to 1s, all of which are measured at the Medical Implant Communication Service (MICS) band, the Industrial Scientific Medical (ISM) band and the Ultra-Wideband (UWB) band. Root mean square fittings of three different functions to received signal strength measurements were performed for different scenarios. Results show that the Gaussian function generally provides a good fitting model, which is independent of center frequencies.
Influence of Beryllides on the Corrosion of Commercial Grades of Beryllium

Abstract The bulk form of the Be intermetallics FeAlBe4, FeBe5, and TiBe12 were examined in solutions ranging in pH from 2 to 12.5 at ambient temperature. The intermetallics were manufactured by ar...
The year in health care delivery and outcomes research.

Outcomes research is applied clinical and population-based research that seeks to study and optimize the end results of health care—that is, the experience of the patient and the impact on society. All studies have outcomes, but this research is distinctive because of its focus on the end result
Librational motions of membrane-embedded Ca2+-ATPase of sarcoplasmic reticulum labeled with fluorescein isothiocyanate.

Abstract Continuing our investigation of the relationships between internal motions and functional properties of soluble and membrane-bound proteins we have explored the lifetimes and correlation times associated with the fluorescence emission of fluorescein-labeled Ca 2+ -dependent ATPase of sarcoplasmic reticulum. The emission was characterized by two lifetime components near 1.8 and 4.1 ns, probably due to exposure of the probe to environments of different polarities. The time-dependent anisotropy showed the presence of two correlation times near 0.8 and 6.6 ns. The shorter correlation time was due to motions of the probe around its point of attachment on the surface of the protein. The longer correlation time indicated the presence of internal motions of the protein. Both lifetimes and correlation times were insensitive to temperature between 2 and 10°C. They were also insensitive to addition and removal of 100 μM free Ca 2+
Non-approximability of precedence-constrained sequencing to minimize setups

It is a basic scheduling problem to sequence a set of precedence-constrained tasks to minimize the number of setups, where the tasks are partitioned into classes that require the same setup. We prove a conjecture in (Ph.D. Thesis, School of ISyE, Georgia Institute of Technology, August 1986; Oper. Res. 39 (1991) 1012) that no polynomial-time algorithm for this problem has constant worst-case performance ratio unless P = NP. A very simple algorithm has performance ratio √n.
The University of Tennessee at Martin (UTM) and Lane College (LC) Urban - Rural Exchange Partnership Program Phase One: The Purpose and Plan

Abstract This article highlights a partnership between an historically Black urban institution, Lane College (Jackson, Tennessee) and a rural institution, The University of Tennessee at Martin (Martin, Tennessee). The purpose of the partnership is to provide urban - rural early field experience exchange for preservice students, conduct joint educational seminars, prepare preservice students for the National Teacher Examination (NTE), provide technological training, recruit minorities for careers in teaching, and establish a mutual assistance network for accreditation.
Synthesis of [PtCl2(4,4′-dialkoxy-2,2′-bipyridine)] complexes and their in vitro anticancer properties

A series of [Pt(II)Cl2(4,4′-dialkoxy-2,2′-bipyridine)] complexes of the general formula of [Pt(II)Cl2(4,4′-bis(RO)-2,2′-bipyridine)] (where R = –(CH2)n−1CH3, n = 2–6, 8) were synthesized and characterized using 1H NMR, 13C NMR spectroscopy, elemental analysis, mass spectroscopy, and differential scanning calorimetry measurements. The in vitro anti-proliferative activities of these compounds were evaluated against human cancer cell lines A549 (lung adenocarcinoma), DU145 (prostate carcinoma), MCF-7 (breast adenocarcinoma), and MDA-MB-435 (melanoma) using the MTS cell proliferation assay. Several Pt(II) coordination compounds were found to have greatly enhanced activity compared to cisplatin after a one hour treatment in all cell lines tested. A structure–activity relationship was observed, that is, the activity increases as the carbon chain length of the alkyl group increases. The activity was maximum when the carbon chain length reached four or five carbons and decreased with the longer carbon chain length. Fluorescence microscopy and flow cytometry data indicate that the main mode of cell death is through apoptosis with some necrotic responses.
Peptide transmitters of primary sensory neurons: similar actions of tachykinins and bombesin-like peptides.

Abstract Previous studies have demonstrated that two peptides, substance P (SP) and substance K (SK), are contained in a common prohormone—β-preprotachykinin [33]. Both peptides are cleaved from the prohormone and appear to coexist throughout the brain [43]. This study evaluated the behavioral activity of SK and compared it to the activities of SP, bombesin (BN), and structurally related peptides. After intraspinal injection, all of the peptides induced “bite/scratch” behaviors, which differed in durations of action. The specific rank order of these durations of action were: BN > gastrin releasing peptide (GRP)=ranatensin (RT) > neuromedin B (NMB) > kassinin (KASS)=SK=SP and ranged from dose-dependent maxima of approximately 2 min (SP) to approximately 100 min (BN). To examine the possibility that differences in durations of action are due to differences in rates of proteolytic degradation, each peptide was incubated in spinal cord homogenates at 37°C, and the degradation rates were monitored by radioimmunoassay (RIA) and by bioassay. The lengths of incubation time required to produce approximately 90% degradation of peptide immunoreactivity varied across peptides from less than 5 min (SP) to more than 60 min (BN and RT). Degradation of bioactivity generally paralleled degradation of immunoreactivity. The results of this study suggest that durations of nociceptive effects produced by the peptides tested are due, in part, to their resistance to proteolytic degradation.
Sum-frequency vibrational spectroscopic studies of water/vapor interfaces

Phase-sensitive sum-frequency vibrational spectroscopy was used to obtain the OH and OD stretch spectra of the imaginary part of the nonlinear susceptibility, ImχS(2)(ωIR), for H2O/vapor, D2O/vapor, and 2:1 H2O–D2O/vapor interfaces that explicitly characterize their resonances. They all exhibit a positive and a negative resonance band in the bonded-OH region, clearly different from those deduced from fitting of the |χS(2)(ωIR)|2 spectra, and from MD simulations. The broad continuum is characteristic of inhomogeneously broadened resonances associated with interfacial water species of various hydrogen-bonding geometries and strengths. Spectral changes due to excess ions at the interfaces support the picture.
The probability that a matrix has a saddle point

Abstract Given a “randomly selected” m × n matrix, the probability that it has a saddle point is m!n! (m + n − 1)! .
An in vitro comparison of the mechanical characteristics of three sagittal ramus osteotomy fixation techniques

Abstract Purpose: The purpose of this in vitro investigation was to compare the mechanical characteristics of three techniques for the rigid internal fixation of simulated sagittal ramus osteotomies in terms of their ability to resist vertical loads resembling masticatory forces. Materials and Methods: Fifteen bovine ribs of similar size and shape were subjected to uniform osteotomies resembling a sagittal ramus osteotomy. They were divided into three groups and fixed with three 2.0-mm bicortical positional screws in an inverted L-pattern, eight monocortical screws and a sagittal strut plate, or a hybrid system using three 2.0-mm bicortical positional screws, five 2.0-mm monocortical screws, and a sagittal strut plate. The repaired ribs were secured in a jig, subjected to vertically deforming forces, and evaluated for yield load, yield point, maximum load, displacement at maximum load, load at 3.0 mm displacement, and stiffness. The various groups were compared statistically with a Scheffe multiple comparison test. Results: No statistically significant differences existed between the positional screw group and the hybrid group ( P > .05). No statistically significant differences were noted in yield displacement, yield load, displacement at maximum load, for any of the groups ( P > .05). There were differences noted between the monocortical strut group and other groups in maximum load, load at 3.0 mm displacement, and stiffness ( P > .05). Conclusions: The monocortically fixed sagittal strut plate offers less resistance to maximum load and loads at 3.0 mm displacement and is less stiff than either a three-positional screw system or a hybrid system. No differences existed between the three positional screw systems and the hybrid system. However, given the low yield loads and yield displacements, these differences may not be clinically important.
Actin-organelle interaction: association with chloroplast in arabidopsis leaf mesophyll cells.

The role of the cytoskeleton in the regulation of chloroplast motility and positioning has been investigated by studying: (1) structural relationship of actin microfilaments, microtubules, and chloroplasts in cryofixed and freeze-substituted leaf cells of Arabidopsis; and (2) the effects of anti-actin (Latrunculin B; LAT-B) and anti-microtubule (Oryzalin) drugs on intracellular distribution of chloroplasts. Immunolabeling of leaf cells with two plant-actin specific antibodies, which react equivalently with all the expressed Arabidopsis actins, revealed two arrangements of actin microfilaments: longitudinal arrays of thick actin bundles and randomly oriented thin actin filaments that extended from the bundles. Chloroplasts were either aligned along the actin bundles or closely associated with the fine filaments. Baskets of actin microfilaments were also observed around the chloroplasts. The leaf cells labeled with an anti-tubulin antibody showed dense transverse arrays of cortical microtubules that exhibited no apparent association with chloroplasts. The application of LAT-B severely disrupted actin filaments and their association with chloroplasts. In addition, LAT-B induced aberrant aggregation of chloroplasts in the mesophyll and bundle sheath cells. Double labeling of LAT-B treated cells with anti-actin and anti-tubulin antibodies revealed that the microtubules in these cells were unaffected. Moreover, depolymerization of microtubules with Oryzalin did not affect the distribution of chloroplasts. These results provide evidence for the involvement of actin, but not tubulin, in the movement and positioning of chloroplasts in leaf cells. We propose that using motor molecules, some chloroplasts migrate along the actin cables directly, while others are pulled along the cables by the fine actin filaments. The baskets of microfilaments may anchor the chloroplasts during streaming and allow control over proper three-dimensional orientation to light.
Classification of buried objects based on ground-penetrating radar measurements and multiple test procedures

This paper describes how Multiple Test Procedures (MTP) can be used to achieve control over the false alarm rate in a landmine detection system. The system is based on an impulse radar to detect objects buried underground. An impulse radar combined with a detector can detect both metallic and non- metallic objects. To be able to distinguish mines from nuisance objects the detector can be followed by a classifier. One drawback with this setting is that it is very difficult to control the false alarm rate of the complete detector/classifier system. The use of MTPs is a systematic way to control the false alarm rate.
Mechanics of crack propagation in delamination wear

Abstract A mathematical model of subsurface crack propagation in sliding contact is developed. It is shown that linear elastic fracture mechanics may be applied to such problems, even for elastoplastic solids. An equation to predict wear rates is derived, which should apply in delamination wear to materials in which crack nucleation is easy. Results of calculations of stress intensity factors for various subsurface cracks and coefficients of friction are presented. The numerical calculations were done only for coefficients of friction greater than 0.5. The calculations show that there is a characteristic crack propagation depth below the surface, which increases with increasing coefficient of friction. In addition, the change in stress intensity factor and hence the crack propagation rate, increases with increasing coefficient of friction. A comparison between these calculations and approximate crack growth rates in sliding wear shows that the results agree reasonably well. The model is used to explain the phenomenon that increased hardness sometimes increases wear. A possible explanation for seizure in geometrically constrained systems is advanced. The model may be used to predict wear rates from first principles in the near future.
Historical development of the saltmarsh at Wells, Maine

Comparisons of maps and aerial photographs dating from the late 1700s to the present document the recent development of an 8 km2 saltmarsh that is situated behind a barrier spit in southern Maine. Tidal channels that were relatively narrow in 1794 became wider by 1872. The reduction of marsh bordering tidal channels is interpreted as evidence that marsh accretion could not keep pace with rising sea-level. This suggests that the rate of sea-level rise had increased, although a change in discharge or sediment load caused by extensive settlement and land clearance may also have been involved. Meander patterns of the tidal streams changed considerably throughout the time period covered by the maps, demonstrating that the streams of this marsh are more dynamic than some others that have been widely reported in the literature. These differences in stream dynamics are probably related to the differences in sedimentological structure of the marshes. Between 1872 and 1956 the barrier spit eroded on its inside (shoreward) edge, probably in response to the construction of riprapping and houses along the spit, and the subsequent reduction of overwash and aeolian transport of sediment. Modification of the tidal inlet and adjacent marsh during the 1960s, including jetty construction, dredging, and filling of portions of the marsh surface, affected the marsh only locally. One tidal stream has been migrating rapidly apparently in response to compaction of peat by dredge spoils and consequent local disruption of the marsh hydrology. Except for this migration, erosion of the marsh edge occurred immediately after the inlet modifications; planimetric changes in the marsh and its streams have been minor since then.
The Influence of Emotion Regulation on Social Interactive Decision-Making

Although adequate emotion regulation is considered to be essential in every day life, it is especially important in social interactions. However, the question as to what extent two different regulation strategies are effective in changing decision-making in a consequential socially interactive context remains unanswered. We investigated the effect of expressive suppression and emotional reappraisal on strategic decision-making in a social interactive task, that is, the Ultimatum Game. As hypothesized, participants in the emotional reappraisal condition accepted unfair offers more often than participants in the suppression and no-regulation condition. Additionally, the effect of emotional reappraisal influenced the amount of money participants proposed during a second interaction with partners that had treated them unfairly in a previous interaction. These results support and extend previous findings that emotional reappraisal as compared to expressive suppression, is a powerful regulation strategy that influences and changes how we interact with others even in the face of inequity.
PS3-24: HMORN Sites: Organization Models and Their Data.

Background/Aims We aim to describe the various organization models across the HMORN and the resulting data.
Simplicity of linear ordinary differential operators

Let A be a closed symmetric operator in a Hilbert space 6. A is said to be simple if there is no nontrivial reducing subspace in which A is self-adjoint. Note that if A is simple, then A does not have eigenvalues. In this article it is shown that the minimal closed symmetric operator T,, determined by a formally self-adjoint linear ordinary differential operator L on an interval (a, b) is simple if L is regular or quasi regular at one end. The proof uses a generalized resolvent and spectral function of T,, and the Stieltjes inversion formula. It is also shown that if L has order n = 1 or if L has real coefficients and order n = 2 (i.e., L is a Sturm-Liouville operator), operator), then T,, is simple or self-adjoint whatever the behavior of L at a and 6. A is said to be regular if every complex number 1 is a point of regular type, i.e., (A ZE)-l exists and is bounded. (Here E is the identity operator.) If A is regular, then A is simple. For, suppose A = A, @ A, , where A, is a nontrivial self-adjoint operator, and A, is closed symmetric. Then I is a point of regular type for A if and only if 1 is a point of regular type for A, and A, . But, since A, is self-adjoint, its spectrum is nonempty and therefore not every point is of regular type for A, . Hence, not every point is of regular type for A, and A is not regular. Thus, if A is regular, A is simple. The converse of this statement is not true. In Section 3, Remark 4, we shall give an example of a closed symmetric operator A which is simple but not regular. We note that the symmetric operators defined by Jacobi matrices and considered by Stone [8, Theorem IO.411 are simple whenever the deficiency mdex is (I, 1). This is because such a symmetric operator A has two different
Silicon micromachining technologies: future needs and challenges

This paper reviews recent developments in micromachining technologies for the fabrication of microsensors, microactuators, and integrated microsystems, and discusses the requirements that micromachining technologies have to satisfy for many present and emerging applications. First, the paper discusses the challenges that micromachining technologies have to overcome and features that they have to provide for many future applications. Micromachining technologies have to be simple so that high yield and low cost can be achieved in manufacturing , they have to be capable of producing microstructures with a variety of shapes and sizes in all three dimensions, many of them have to be compatible with integration with electronics, they have to be capable of providing packaging and encapsulation at the wafer level for many devices that require operation in hermetic and/or vacuum environments, and finally they have to be capable of supporting a mixed set of materials, technologies and devices. Significant progress has been made in all of these areas during the past few years and several groups have developed new techniques that satisfy some or all of these requirements. The paper also reviews the most recent advances in the three mainstream technologies of bulk silicon micromachining, surface micromachining, and electroplating techniques. As microsystems become more complex, these three mainstream technologies will be increasingly used and combined to build complex systems at low cost.
Design options for low-conductivity window frames

Abstract The window industry's commercialization of low-emissivity coatings and low-conductivity gas-filling over the past few years has helped to drastically reduce heat transfer rates through the glazed areas of windows. However, few changes have taken place in the design and construction of window frames and edges, leaving these elements to account for most of the heat transfer through today's state-of-the-art windows. This paper presents design and material requirements for the manufacture of low conductivity window frames obtained through the use of finite element computer modeling. Such frames will compliment and not degrade today's most-energy-efficient insulated glass units.
Characterization of masses on mammograms: Significance of using the rubber-band straightening transform

The rubber-band straightening transform (RBST) was developed for characterization of mammographic masses as malignant or benign. The RBST maps a region surrounding a segmented mass on a mammogram onto the Cartesian plane. In this study, the effectiveness of texture features extracted from the RBST images was compared with the effectiveness of those extracted from the original images. Texture features were extracted from (1) a region of interest (ROI) centered at the mass; (2) a 40-pixel-wide gray-scale region surrounding the perimeter of the mass; and (3) the RBST image. Two types of texture features were extracted; spatial gray level dependence (SGLD) features and run-length statistics (RLS) features. Linear discriminant analysis and leave-one-case- out methods were used for classification in the individual or combined feature spaces. The classification accuracy was evaluated by receiver operating characteristic (ROC) analysis and the area Az under the ROC curve. CLABROC analysis was used to estimate the statistical significance of the difference between features extracted using the three different approaches. On a database of 255 ROIs containing biopsy-proven masses, the Az value was 0.92 when combined SGLD and RLS features extracted from RBST images were used for classification. In comparison, the combined texture features extracted from the entire ROIs and the mass perimeter regions resulted in Az values of 0.83 and 0.85, respectively. The improvement in Az obtained by using RBST images was statistically significant (p less than 0.05). Similar levels of significance were observed when the classification was performed in the SGLD feature space alone or the RLS feature space alone.© (1997) COPYRIGHT SPIE--The International Society for Optical Engineering. Downloading of the abstract is permitted for personal use only.
Reduction of mating potential of male Heliothis spp. and Spodoptera frugiperda in field plots treated with disruptants.

A close correlation existed between the reductions in capture of males by ♀-baited traps and the reductions in mating by females (relative to controls) of Heliothis zea (Boddie) and H. virescens (F.) in small field plots treated with ( Z )-9-tetradecen-1-ol formate. Similar correlated reductions in trap capture and mating by Spodoptera frugiperda (J. E. Smith) were recorded in plots treated with ( Z,E )-9,12-tetradecadien-1-ol acetate. When these 2 chemicals were evaporated simultaneously from separate dispensers in the same plot, mating of H. zea and S. frugiperda females was reduced by 87 and 92%, respectively. In small field tests, ( Z )-l1-hexadecenal, a component of the H. virescens pheromone, reduced the mating of H. zea females by 85%. ( Z )-9-tetradecenal, another component of the H. virescens pheromone, was ineffective against H. zea but reduced the mating of H. virescens females by 95%.
Call obligations in radiology residency: a survey.

Rationale and Objectives. The authors evaluated the initial assignment of call responsibilities during residency, the effect on call obligations of the number of residents, and the differences between private and university programs and level 1 and non-level 1 trauma centers. Materials and Methods. A survey was sent to all 203 diagnostic radiology residency programs accredited by the Accreditation Council for Graduate Medical Education. Chief residents at 21 institutions were surveyed by phone or in person. Directors of residency programs in the Graduate Medical Education Directory received the survey electronically. Results. Responses were received from 99 (68 university, 31 private practice) of the 203 programs. Nine (9%) reported both a decreased number of residents and a subsequent increase in call obligations. First-year residents generally began to accept calls with a senior resident or alone at a median of 6 months, although 15 (48%) private practice programs required them to accept calls alone before this time. First-year residents at university programs (31%) were more likely to assume call duties during the first 6 months accompanied by a senior resident. Maximum time before 1st-year residents started going on call was 13 months. Conclusion. Call obligations remain a resident responsibility. University and private practice programs differ more than level 1 and non-level 1 trauma centers.
Testing effeciency in Gambling markets: a comment

In a recent article in this journal, Even and noble point out that the regression-based test for unbiasedness in point spread betting markets is not valid test when the mean and median of the market's forecast errors are different. In the case where skewness is present, Even and noble propose a likelihood ratio statistic to test for market efficiency. In this comment, three concerns are explored: (i) whether distributions of market forecast errors in these markets are consistently and significantly skewed; (ii)whether the test proposed by Even and Noble suffers from the same problem of low power as do other statistical tests in these markets;(iii)whether the Even and Noble test statistic is actually a new test or simply the equivalent of very simple, well-known statistical test.
The Road to East Slope: The Development of Su Shi’s Poetic Voice

Su Shi (1037-1101) is the greatest poet of the Song Dynasty, a man whose writings and image defined some of the enduring central themes of the Chinese cultural tradition. Su Shi was not only the best poet of his time, he was also a government official, a major prose stylist, a noted calligrapher, an avid herbalist, a dabbler in alchemy, and a broadly learned scholar.The author shows how this complex personality was embodied in Su Shi's work and traces the evolution of his poems from juvenilia to the poems written in exile in Huangzhou, where Su settled on a farm at East Slope.
The determined state of white expression in the Drosophila eye is modified by zeste1 in the wzm family of mutants.

Analysis of the white zeste mottled (wzm) mutant family suggests that the zeste gene product functions in establishing and stabilizing a transcriptionally active chromatin domain for white locus expression. The z 1 mutation reduces expression of paired or proximate copies of white, while single or unpaired copies maintain wildtype levels of expression. The w zm mutation, caused by the insertion of the retrotransposon BEL into the 5′ intron of white, alters the zeste-white interaction to produce a mottled eye phenotype in hemizygous z 1 w zm males. We have determined the molecular structure of four w zm derivatives. w zl results from the insertion of an additional transposable element into the 5′ regulatory region of white. w zvlis a deletion of sequences upstream of the white locus. Two others, w haloand w cres, result from the transposition of w zmplus the entire verticals-roughest region into heterochromatin near the tip of chromosome 3L. They variegate for roughest but not for white; rather, the z 1 effect on w zmnow causes white expression to become non-autonomous and non-clonal. The analysis of these five mutations shows that the neomorphic zeste 1 product, in combination with structural changes imposed by transposons and intercalary heterochromatin, modifies the determination and stability of white expression. We propose that the normal zeste product functions as part of a complex that stimulates transcription by changing chromatin conformation to establish and maintain transcriptionally active domains. The unpairing of homologs is proposed to be one of the initial results of conformational change, providing an explanation for the role of zeste in transvection.
Live birth of a normal mature healthy baby by in vitro fertilization–embryo transfer (IVF-ET) after an exploratory laparotomy and multiple myomectomy for leiomyomatosis peritonealis disseminata

Objective To report a case of a live birth of a normal mature healthy baby by IVF-ET after an exploratory laparotomy and multiple myomectomy for leiomyomatosis peritonealis disseminata. Design Case report. Setting Academic university hospital. Patient(s) A 37-year-old female G2P0 with secondary infertility diagnosed with leiomyomatosis peritonealis disseminata who underwent surgical resection and IVF stimulation. Intervention(s) One cycle of IVF-ET initiated with Gonal F and Menopur. Main Outcome Measure(s) Live birth of a normal mature healthy baby. Conclusion(s) IVF-ET can produce a normal healthy baby in a patient with leiomyomatosis peritonealis disseminata.
Localization of proteins to the nucleus

Nuclear proteins are synthesized in the cytoplasm and must subsequently enter the nucleus. Recent experiments indicate some similarities and some differences between protein localization to the nucleus and localization to other organelles.
HABITAT AND HOST SPECIFICITY OF TREMATODE METACERCARIAE IN FIDDLER CRABS FROM MANGROVE HABITATS IN FLORIDA

Fiddler crabs (Uca spp.) are common inhabitants of temperate and tropical coastal communities throughout the world, often occupying specific microenvironments within mangrove and salt marsh habitats. As second intermediate hosts for trematodes, we investigated patterns of host distribution and parasitism for 3 species of sympatric fiddler crabs in mangrove habitats adjacent to the Indian River Lagoon, Florida. Fiddler crab distribution varied among species, with Uca speciosa dominating the low and mid intertidal regions of mangrove banks. This species also exhibited higher prevalence and abundance of Probolocoryphe lanceolata metacercariae compared with Uca rapax, which is relatively more abundant in the high intertidal zone. We conducted a field experiment to test whether U. speciosa was more heavily parasitized by P. lanceolata as a result of its habitat distribution by raising U. speciosa and U. rapax under identical environmental conditions. After exposure to shedding cercariae under the same field conditions, all individuals of U. speciosa became parasitized by P. lanceolata, whereas no U. rapax were parasitized, suggesting that differences in parasitism were driven by host selection.
Supplementary Conditions in the Quantized Gravitational Theory

The role of the supplementary conditions in the quantum theory of gravitation is discussed in a simplified and unambiguous manner by means of a Lagrangian formalism involving the use of the ordered products. The consistency of the supplementary conditions for the general nonlinear gravitational field interacting with the matter field is established.
A parallel multi-domain solution methodology applied to nonlinear thermal transport problems in nuclear fuel pins

This paper describes an efficient and nonlinearly consistent parallel solution methodology for solving coupled nonlinear thermal transport problems that occur in nuclear reactor applications over hundreds of individual 3D physical subdomains. Efficiency is obtained by leveraging knowledge of the physical domains, the physics on individual domains, and the couplings between them for preconditioning within a Jacobian Free Newton Krylov method. Details of the computational infrastructure that enabled this work, namely the open source Advanced Multi-Physics (AMP) package developed by the authors is described. Details of verification and validation experiments, and parallel performance analysis in weak and strong scaling studies demonstrating the achieved efficiency of the algorithm are presented. Furthermore, numerical experiments demonstrate that the preconditioner developed is independent of the number of fuel subdomains in a fuel rod, which is particularly important when simulating different types of fuel rods. Finally, we demonstrate the power of the coupling methodology by considering problems with couplings between surface and volume physics and coupling of nonlinear thermal transport in fuel rods to an external radiation transport code.
Reflexive mimesis in contemporary visual culture

Abstract A significant strand of new work in visual culture shows figures expressing extreme emotion. Such produces an experience of what I call “reflexive mimesis.” Modernism eschewed mimesis in favor of reflexivity; mass culture largely took over the role of producing mimetic experience for its audience. “Reflexive mimesis” represents an alternative that does not seek to deny or interrupt our mimetic capacity; indeed I argue that such work explores mimesis as a technique for experiencing ourselves as “mimetic animals.” However, this work is reflexive, not ideological. Among the artists considered in this chapter are Bill Viola, Chloe Piene, Paul Pfeiffer, Sam Taylor-Wood and Andy Warhol.
Another look at amphetamine-induced stereotyped locomotor activity in rats using a new statistic to measure locomotor stereotypy

Rat open field behavior is often used as a tool to study the behavioral effects of drugs. In this report, drug-induced patterns of locomotion in an open field were studied with the aid of a simple new statistic. Briefly, the animal's path through the open field is converted into a series of trips. Gamma (\(\hat \gamma\)) estimates the probability that the animal will repeat the trip that it has just exhibited; thus \(\hat \gamma\)quantifies “locomotor stereotypy”. Trip lengths can also be compared across drug groups. Thus caffeine has no effect on \(\hat \gamma\) even though it produces a dose-related increase in locomotions. Caffeine does not produce amphetamine-like stereotypy. On the other hand, amphetamine produces a dose-related increase in \(\hat \gamma\). Although \(\hat \gamma\) was designed to detect any pattern of locomotor behavior, rats treated with high doses of amphetamine almost always exhibited the same pattern of locomotor behavior — repetitive trips around the perimeter of the open field. Although further characterization of the statistic is necessary, these findings suggest that \(\hat \gamma\) has potential for quantifying “locomotor stereotypy” and for providing a more subtle description of locomotor behavior in general.
Laser studies of internal conical diffraction. II. Intensity patterns in an optically active crystal, α-iodic acid*

The intensity patterns produced by a Gaussian (TEM00 mode) laser beam propagating in the vicinity of the optical axis of α-iodic acid have been photographed. Densitometric profiles for different polarization conditions have been obtained. The theory of Portigal and Burstein has been extended to permit a quantitative comparison between theory and experiment for conical refraction in noncentrosymmetric crystals.
STEROID TREATMENT OF HEMOPHILIC HEMATURIA.

Summary Cessation of hematuria was observed in three hemophilic patients following treatment with corticosteroids administered orally or intravenously. The mechanism of action of steroid therapy in this disorder is unknown, but further evaluation of its usefulness would appear warranted.
Applications of Molecular Diagnostics: Solid Tumor Genetics Can Determine Clinical Treatment Protocols

Solid tumor diagnosis is now entering an era in which molecular genetics plays an important role. Clinical trials have shown different responses to various therapies that correlate with molecular alterations. Biological determinants related to treatment response markers aimed at individualized therapies are being defined and implemented. Patients are now being treated based on the profile of molecular genetic alterations in individual tumors. Protocols based on molecular markers will increase the chances for cure by opting for the right management approach. They also will improve, in most situations, the quality of life of patients with cancer, for example by facilitating organ preservation strategies. The molecular characterization therefore has an important prognostic and practical role in diagnosis.
Dwarf Ball and Dwarf Wall: Design, instrumentation, and response characteristics of a 4π CsI(Tl) plastic phoswich multidetector system for light charged particle and intermediate mass fragment spectrometry

Abstract A 4π multidetector intermediate mass fragment and charged particle spectrometer is described. It consists of the Dwarf Ball section with 65 CsI(Tl) plastic scintillator phoswiches closely packed to cover the angular range of 32°–168°, and the Dwarf Wall section, with 40 CsI(Tl) plastic phoswiches covering the angular range of 4°–32°. For each detector that fires, three regions of the photomultiplier anode current are separately integrated; one at early times for the fast plastic ΔE, another at intermediate times for the bulk of the signal from the CsI(Tl), and a third in the tail region of the CsI(Tl) signal. In addition, the times are recorded for each detector that fires. From this information, 1,2,3H, 3,4He and the elements from Li to Mn can be identified and their energies measured over a large dynamic range. The geometry, construction, energy calibration, gain stability, associated electronics, and an approximate light charged particle identification procedure are discussed. Examples of the performance of the spectrometer from heavy-ion induced reaction experiments are given. The capabilities of this device as a channel selecting device in conjunction with the spin spectrometer are also discussed.
Dislocation reactions in arsenic‐implanted and annealed silicon

Arsenic implantation into Si and annealing at 800°C creates a high density of small interstitial dislocation loops. Further annealing in the range of 900°C to 1000°C causes coarser dislocation structures which depend on the initial implantation conditions. After implantation through thin SiO2 layers large winding dislocation loops of shear type are obtained. A detailed account is given of the transformation of small interstitial loops into large shear loops. Wenn man Arsen in Silizium implantiert und bei 800°C tempert, entsteht eine hohe Dichte kleiner interstitieller Versetzungsschleifen. Weiteres Tempern bei 900 bis 1000°C fuhrt zu groberen Versetzungsstrukturen, deren Art von den anfanglichen Implantationsbedingungen abhangt. Nach Implantation durch dunne SiO2-Schichten hindurch entstehen grose kletternde Versetzungsschleifen vom Scherungstyp. Es wird eine ausfuhrliche Betrachtung zur Umwandlung der kleinen interstitiellen Schleifen in grose Scherungsschleifen durchgefuhrt.
Integrating human behavior and response issues into fire safety management of facilities

Although there is a growing international movement toward the use of engineered or performance‐based fire safety design, current practice is dominated by prescriptive‐based design. In prescriptive‐based fire safety design, only those requirements prescribed by appropriate building regulations, installation standards, or approved documents tend to be applied. Because these requirements typically include fire protection measures, such as fire detection and signaling systems, automatic sprinkler systems, fire compartmentation, and emergency egress systems, there is often an assumption that occupants, employees, and users of a facility will be safe should a fire occur. However, there are a variety of factors that could affect the actual fire safety of a facility that comply with the appropriate regulations. Fuel type, loading, configuration, and location can change, leading to an increase in fire risk. Occupants may not see, hear or understand fire alarm signals as fire alarm signals. Fire detection and signa...
The Satter Eating Competence Inventory for Low-income persons is a valid measure of eating competence for persons of higher socioeconomic position.

Eating competence is an important behavioral construct, shown to be associated with healthful lifestyle practices, including dietary quality, weight management, physical activity, and sleep duration. A 16-item instrument to measure eating competence, the Satter Eating Competence Inventory was previously validated in a general sample and subsequently, a 16-item instrument was developed to address specific concerns of low-income persons; 12 items were common to both instruments. The purpose of this study was to determine if the low-income version could be applied to a general audience, simplifying intervention evaluation and facilitating cross-study comparison. Both surveys were fully completed by 127 parents (89% white; 35.8 ± 5.3 y; 86% college graduates; 51% eating competent) of preschool-age children; 96 of whom were not considered low-income. Cognitive interviews with 14 parents of varying eating competence levels clarified and confirmed findings. Scores were highly correlated (r = .98) and only 2 of the 96 were not congruently classified for eating competence. Mean difference between the two versions was .24 ± 1.55. The general audience version explained 95% of the variance in the low-income version score. Findings support the low-income version of the Satter Eating Competence Inventory for general audience use as the Satter Eating Competence Inventory 2.0.
Algebras, polynomial and programs

Abstract This paper presents an introduction to some of the more algebraic applications of elementary category theory in computer science. Topics include: a category based look at universal algebra; the definition of polynomials over arbitrary algebras and their application to the study of substitution; a development of Lawvere algebraic theories based on polynomials, and the application of such theories to algebra and to the study of iteration and recursion in programming languages.
Redox reactions of the pyranopterin system of the molybdenum cofactor

This work provides the first extensive study of the redox reactivity of the pyranopterin system that is a component of the catalytic site of all molybdenum and tungsten enzymes possessing molybdopterin. The pyranopterin system possesses certain characteristics typical of tetrahydropterins, such as a reduced pyrazine ring; however, it behaves as a dihydropterin in redox reactions with oxidants. Titrations using ferricyanide and dichloroindophenol (DCIP) prove a 2e−/2H+ stoichiometry for pyranopterin oxidations. Oxidations of pyranopterin by Fe(CN)6 3− or DCIP are slower than tetrahydropterin oxidation under a variety of conditions, but are considerably faster than observed for oxidations of dihydropterin. The rate of pyranopterin oxidation by DCIP was studied in a variety of media. In aqueous buffered solution the pyranopterin oxidation rate has minimal pH dependence, whereas the rate of tetrahydropterin oxidation decreases 100-fold over the pH range 7.4–8.5. Although pyranopterin reacts as a dihydropterin with oxidants, it resists further reduction to a tetrahydropterin. No reduction was achieved by catalytic hydrogenation, even after several days. The reducing ability of the commonly used biological reductants dithionite and methyl viologen radical cation was investigated, but experiments showed no evidence of pyranopterin reduction by any of these reducing agents. This study illustrates the dual personalities of pyranopterin and underscores the unique place that the pyranopterin system holds in the spectrum of pterin redox reactions. The work presented here has important implications for understanding the biosynthesis and reaction chemistry of the pyranopterin cofactor in molybdenum and tungsten enzymes.
Metronomic chemoimmunotherapy in a patient with refractory Waldenstrom's macroglobulinemia.

Increasing knowledge of the angiogenesis role in cancer metastasis has led to application of low-dose, continuous intravenous (or oral) chemotherapy over extended time periods to inhibit the prolif...