cssi/SciSciGPT-SciSciNet huggingface dataset:
Preparation Of Nanocomposites With Well-Defined Organic (Co)Polymers

Nanocomposites with well-defined organic polymers are hybrid materials with large interphase between two incompatible organic and inorganic segments. The well-defined organic segments are generated by controlled/living polymerization. Due to its simplicity, robustness and tolerance to impurities, radical polymerization is preferred. Atom transfer radical polymerization has been most often used, since it is perhaps most versatile. Inorganic component can comprise colloidal spherical particles, flat layered structures or macroscopically flat wafers but also irregular inorganic surfaces. The nancomposites are formed by covalent linkage between the incompatible organic and inorganic parts. Both grafting from surfaces and onto surfaces was employed for that purpose. Spherical polymer brushes were synthesized by the ATRP of styrene, n-butyl acrylate and methyl methacrylate from initiators covalently attached to the surface of colloidal silica and silsesquioxanes. In a similar way core-shell colloids were prepared by block copolymerization using ATRP. Polymer brushes were formed by grafting from and onto flat silicon surfaces and functionalized carbon black.
Systematics of the Acanthoparyphinae (Trilobita), with species from the Silurian of Arctic Canada

Cladistic analysis of the trilobite subfamily Acanthoparyphinae Whittington and Evitt, 1954, yields an explicit hypothesis of relationship for the group. All Silurian species together form a robustly supported monophylum including the genera Hyrokybe Lane, 1972, Parayoungia Chatterton and Perry, 1984, and Youngia Lindstrom, 1885. Sister to this is the Ordovician type species of Acanthoparypha Whittington and Evitt, 1954. Remaining species that have historically been assigned to either Acanthoparypha or Pandaspinapyga Esker and Levin, 1964, form a rather labile paraphylum. Nevertheless, the entire group thus identified is definitely monophyletic, and supported by several prominent synapomorphic character-states. The basal structure and basal node of the subfamily are more difficult to assess. The relationships of the genera Hammannopyge Pribyl, Vanek, and Pek, 1985, Holia Bradley, 1930, and Nieszkowskia Schmidt, 1881, need to be addressed within the wider context of the family as a whole. The traditional assignment of Holia to the acanthoparyphines is followed. Wenlock acanthoparyphines from the Cape Phillips Formation of the central Canadian Arctic islands include several species of Hyrokybe and Parayoungia. They are similar to, and in one case conspecific with, coeval forms to the southwest in the southern Mackenzie Mountains. Five species are new: Holia glabra, Hyrokybe lightfooti, Hyrokybe youngi, Hyrokybe mitchellae, and Parayoungia mclaughlini. At least four other potentially new species are reported in open nomenclature.
Introduction: Reading Ethics and Logics of Individuation in the Southern Cone

In this introductory chapter, I develop the connection between cultural production, ethics, and the logics of individuation—the formation of a discrete mode of identity—as a necessary corrective to other ethical modes. To understand ethics as not only a mIndividuationode of reflection, but a rhetorical mode of inscribing meaning, I develop a reading of three notions derived from the work of Peter Hallward, Gilles Deleuze, and Alain Badiou: The Singular, the Specified, and the Specific. This is the theoretical frame for my book and I establish this in the next chapter, arguing for the necessity to reimagine textual criticism through the Hallwardian frame.
Abstract 4773: Gene-targeted apoptosis as a novel therapeutic strategy for HER2-positive breast cancer

The ability to target HER2-driven breast cancers using anticancer agents with mechanisms of actions that are independent of the HER2 cellular growth function, represents a powerful new tool to circumvent drug resistance experienced with traditional HER2-targeted therapies. We have discovered that manipulation of the balance between the DNA repair response and apoptotic pathways provides an alternative strategy to induce targeted apoptosis in HER2-amplified breast cancers. Our recent finding that triplex-induced DNA damage can activate apoptosis in human cells has yielded the opportunity to develop a new class of HER2-targeted therapies. Here, we have uncovered the novel finding that triplex-induced apoptosis only occurs when multiple triplex structures are formed, while NER (nucleotide excision repair)-dependent repair prevails in the presence of one or two structures. With this in mind, we have designed sequence-specific DNA-binding molecules that create chromosomal triplex structures and activate tumor-specific apoptosis through the induction of excessive DNA damage at the HER2 locus. Importantly, this only occurs in malignant cells with multiple copies of the HER2 gene. We have evaluated the efficacy of the HER2-targeted triplex-forming molecules using cell growth and apoptosis assays and demonstrate that these molecules are particularly effective in eliciting tumor specific apoptosis in HER2-amplified breast cancer cell lines. Furthermore, these molecules have the ability to suppress the growth and metastasis of human HER2-positive breast cancers in a xenograft mouse model. Moreover, we demonstrate that the NER protein, XPD mediates the survival-death decision in response to triplex-induced DNA damage via a p53-independent mechanism that involves phosphorylation of the H2AX tyrosine 142 residue, which stimulates the signaling pathway to recruit pro-apoptotic factors to the damage site. Our results establish an alternative and novel method to specifically target HER2-positive breast cancers by exploiting the cell9s own DNA damage response machinery. This study introduces a new paradigm for gene-targeted drugs that can be used in the treatment of HER2-positive and drug-resistant breast cancers with minimal potential for toxicity to normal tissue. Citation Format: Faye A. Rogers, Meetu Kaushik. Gene-targeted apoptosis as a novel therapeutic strategy for HER2-positive breast cancer. [abstract]. In: Proceedings of the 107th Annual Meeting of the American Association for Cancer Research; 2016 Apr 16-20; New Orleans, LA. Philadelphia (PA): AACR; Cancer Res 2016;76(14 Suppl):Abstract nr 4773.
The Varus-Valgus Constrained Knee Implant: Survivorship and Outcomes.

The purpose of this study was to estimate the survivorship of the varus-valgus constrained (VVC) knee implants in primary, aseptic, and septic revision total knee arthroplasty (TKA); determine functional outcomes; main modes of failure; and variables associated with increased mechanical failures. In this study, 685 consecutive cases of primary (n = 247), aseptic (n = 315), and septic revision (n = 123) TKAs with VVC implants were performed between 1999 and 2008; 533 knees (78%) had a mean follow-up of 8.2 years (range, 2-15.1). Kaplan-Meier method was used to evaluate implant survival with mechanical failure as the end point. Clinical outcomes were measured with a modified Knee Society Score (mKSS) and modified Knee Function Score (mKFS) and modes of failure were determined. Cox proportional hazards models were performed to assess for factors associated with implant failure. Ten-year survival was 88.5% (95% confidence interval [CI]: 83.9-93.5%) for primary TKAs, 75.8% (95% CI: 70.4-81.7%) for aseptic, and 54.6% (95% CI: 43.7-68.2%) for septic revisions. Improvement in pre- to postoperative mKSS and mKFS were significant in all three groups (p < 0.05). The most common mode of failure overall was infection. Mechanical modes of failures included periprosthetic fracture (45%) for primary TKA and soft tissue instability (19%) for aseptic revisions. A longer period since the last surgery in affected knee was associated with lower mechanical failures (hazards ratio of 0.55 [95% CI: 0.31-0.95], p = 0.03). VVC implant showed reliable survivorship at 10 years although careful patient selection is warranted due to the risk of infection. The main mechanical modes of failure were instability and periprosthetic fracture.
SlidePacer: A Presentation Delivery Tool for Instructors of Deaf and Hard of Hearing Students

Following multimedia lectures in mainstream classrooms is challenging for deaf and hard-of-hearing (DHH) students, even when provided with accessibility services. Due to multiple visual sources of information (e.g. teacher, slides, interpreter), these students struggle to divide their attention among several simultaneous sources, which may result in missing important parts of the lecture; as a result, access to information is limited in comparison to their hearing peers, having a negative effect in their academic achievements. In this paper we propose a novel approach to improve classroom accessibility, which focuses on improving the delivery of multimedia lectures. We introduce SlidePacer, a tool that promotes coordination between instructors and sign language interpreters, creating a single instructional unit and synchronizing verbal and visual information sources. We conducted a user study with 60 participants on the effects of SlidePacer in terms of learning performance and gaze behaviors. Results show that SlidePacer is effective in providing increased access to multimedia information; however, we did not find significant improvements in learning performance. We finish by discussing our results and limitations of our user study, and suggest future research avenues that build on these insights.
Exercise Stress Testing

Exercise testing (ET) is a well-validated procedure for the diagnosis of coronary artery disease (CAD) and assessing functional capacity and prognosis. Exercise stress tests may detect myocardial ischemia along the ischemic cascade (Fig. 4.1) as a result of a mismatch between myocardial oxygen delivery (from coronary blood flow impairment) and myocardial oxygen demand. It is simple and easy to perform the test, with minimal equipment required.
Pressure in the Southern Hemisphere

The general distribution of mean pressure at sea level over the Southern Hemisphere has been known since Buchan’s maps were published in 1869. Many others have since appeared, the best known of which are those in Hann’s textbook (1901), and in Shaw’s Manual of Meteorology (1927). Meinardus and Mecking (1911b) combined a series of daily synoptic maps (1 October 1901–31 March 1904) into monthly mean pressure maps of much of the area south of 305, which are still very valuable because of the careful analysis and of the many ships’ observations then, where few, if any, are taken now. Meinardus (1928, 1929) used this series in a study of the pressure which is instructive and unsurpassed, but often ignored. Pressure in the Southern Hemisphere has also been treated by Spitaler (1901), Reuter (1936), Wahl (1942), Gordon (1953), Vowinckel (1955), Schwerdtfeger and Prohaska (1956), Hofmeyr (1957a), van Loon (1961), and Pflugbeil (1967).
Individual- and Family-Level Mobility Effects

This Chapter explores whether or not household mobility has negative effects for individuals, particularly children, and their families. Drawing on a large, interdisciplinary body of research on “mobility effects,” this chapter also explores several reasons why research on the effects of moving on children has led to mixed conclusions. Nationally representative data from the National Longitudinal Survey of Youth 1997 (NLSY97) are used to explore the short and long-term effects of local and distance mobility, including the frequency of moving, across a number of different outcome domains.
Welfare Class Identity and the Rhetoric of Erasure in Academia

This paper explores whether it is true that education can unlock the door to economic opportunity and thus enable disadvantaged groups to "pull themselves up by their bootstraps" allowing them to live the American dream.
Control and operation of medium-voltage high-power bi-directional resonant DC-DC converters in shipboard dc distribution systems

Shipboard power system is moving towards more insertion of medium voltage (MV) dc sub-system in the existing MVAC power system. Isolated bidirectional dc-dc converter, analogous to a dc energy router, is one of the key enabling components in such a MVDC system to inter-tie different dc buses with the capability of power flow control as well as fault isolation. Control of such converters in medium voltage and high power scale is always a challenge to ensure fast power flow dynamic response and high efficient operation. In this paper, a variable frequency and phase-shift control solution is presented to regulate the bi-directional power flow in a 1kV to 5kV MW-class LLC resonant converter. The proposed method achieves soft-switching on all power devices across the entire power range as well as seamless power direction change. In addition, a system level control is implemented to fulfill the multifunctional operations in the shipboard applications. Both the hardware-in-loop (HIL) test and the hardware test results are presented.
Gemcitabine, Busulfan and Melphalan (GemBuMel) Is a New High-Dose Chemotherapy (HDC) Regimen with High Activity In Refractory Hodgkin's Lymphoma (HL) Patients Receiving An Autologous Stem-Cell Transplant (ASCT): A Contemporaneous Comparison with BEAM and Busulfan/Melphalan (BuMel)

Abstract 690 Background: BEAM is considered standard HDC for primary refractory or relapsed HL. However, pts with refractory HL have Methods: We developed a new HDC regimen of gemcitabine (Gem), busulfan (Bu) and melphalan (Mel) (GemBuMel) exploiting their synergy. Bu was given as 4 daily doses on days −8 to −5 targeting an AUC of 4,000/d. Mel was given at 60 mg/m2/d on d-3 and d-2. Gem was infused over 3 hours at a fixed dose rate of 10 mg/m2/min (total dose 1875 mg/m2) on days −8 and −3 immediately preceding Bu and Mel, respectively. We compared the subset of refractory HL pts enrolled in this trial with all other refractory HL pts treated at MDACC with HDC during the same time period, who were eligible for the GemBuMel trial but either received BEAM off protocol or were enrolled in a separate trial of BuMel. All of these pts met ≥1 of the following criteria of refractory disease: primary induction failure (PIF) (defined as less than PR to 1st line chemotherapy), CR1 1 relapse or progressive disease (PD) at HDC. Pts with relapsed but not refractory HL were not included in this analysis. Results: We analyzed 115 pts treated in one of the following three cohorts: 1) GemBuMel (N=51) since 01/07, median follow-up: 10 (2-43) mo; 2) BEAM (N=26) since 01/07, median f/u: 13 (3-56) mo; 3) BuMel (N=38) since 04/05, median f/u: 36 (17-56) mo. The GemBuMel cohort had significantly higher % PIF, median # prior relapses, % PET + tumors at HDC and % PD at HDC, with all other demographic and clinical features comparable (Table 1). There were no treatment-related deaths in any cohort. GemBuMel pts had improved EFS (Fig. 1) and OS (Fig. 2). GemBuMel was superior in patients with either PET- or PET+ tumors at HDC (Table 2). Cox proportional hazards regression models identified the use of a regimen other than GemBuMel (HR 2.38, P=0.02 for EFS; HR 8.25, P=0.009 for OS), >1 prior relapse (HR 2.91, P=0.006 for EFS) and B symptoms (HR 6.57, P=0.009 for OS) as independent adverse outcome predictors. Conclusions: Despite its worse prognostic features, the cohort of refractory HL pts treated with GemBuMel showed superior outcome to contemporaneous patients receiving BEAM or BuMel. A randomized trial of GemBuMel v BEAM is warranted. Disclosures: Off Label Use: Off-label use of gemcitabine for Hodgkin9s lymphoma. Popat:Otsuka: Research Funding. Andersson:Otsuka: Consultancy. Champlin:Otsuka: Research Funding.
The Last Mile Problem: Activists, Advocates, and the Struggle for Justice in Domestic Courts:

The ability of a state to protect its own citizens’ lives is a key part of democratic legitimacy. While the right to physical integrity is nearly universal, holding those who violate this right leg...
The relationship between varicella (chickenpox) and scarlet fever in contemporary Hong Kong

Scarlet fever epidemics have reemerged in China, the UK, and Hong Kong. This research tests whether scarlet fever epidemics in Hong Kong are linked to varicella epidemics. Varicella infection is a known risk for invasive Group A Streptococcal infections, and historical research shows a connection between varicella and scarlet fever. This analysis examines the relationship between these two disease in Hong Kong from 2011 to 2015 and compares varicella rates before and after the reintroduction of scarlet fever. Analysis shows that scarlet fever and varicella have synchronous annual epidemic cycles, and a mathematical model of the relationship between scarlet fever and varicella is estimated. Varicella rates were unchanged by the return of scarlet fever, but annual varicella cycles may have influenced the size and timing of scarlet fever outbreaks. Vaccination policies for varicella may need to be adjusted to limit scarlet fever epidemics.
Severe Metal Hypersensitivity Following Internal Fixation of an Ankle Fracture: A Case Report.

Case: A 67-year-old woman underwent internal fixation of an ankle fracture. Ten days postoperatively, the patient developed systemic hives, difficulty breathing, and oral swelling. At 8 weeks postoperatively, the hardware was removed because of a suspected metal hypersensitivity. Despite experiencing perioral edema and difficulty breathing after the hardware removal, she had complete resolution of the symptoms at the 2-week, 6-week, and 12-month follow-up appointments. Conclusion: Hypersensitivities to metal-based implants can develop and cause local and systemic reactions. Orthopaedic surgeons should inquire about a history of metal allergies, and possibly perform allergy testing for patients with a history suggestive of metal hypersensitivities. Consideration should be given for hospital admission following hardware removal for patient monitoring.
Association between long-term low-intensity cigarette smoking and incidence of smoking-related cancer in the national institutes of health-AARP cohort.

An increasing proportion of US smokers smoke ≤10 cigarettes per day (CPD) or do not smoke every day, yet the health effects of low-intensity smoking are poorly understood. We identified lifelong smokers of <1 or 1-10 CPD and evaluated risk of incident cancer among 238,525 cancer-free adults, aged 59-82, in the NIH-AARP Diet and Health Study. A questionnaire administered in 2004-2005 assessed CPD during nine age-periods (<15 to ≥70). We estimated hazard ratios (HR) and 95% confidence intervals (CI) using multivariable-adjusted Cox proportional hazards regression with age as the underlying time metric. Of the 18,233 current smokers, (7.6%), 137 and 1,243 reported consistently smoking <1 CPD and 1-10 CPD, respectively. Relative to never smokers, current smokers who reported consistently smoking 1-10 CPD over their lifetime were 2.34 (95% CI = 1.86-2.93) times more likely to develop smoking-related cancer. Current lifetime smokers of <1 CPD were 1.89 (95% CI = 0.90-3.96) times more likely to develop tobacco-related cancer, although the association did not reach statistical significance. Associations were observed for lifelong smoking of ≤10 CPD with lung cancer (HR = 9.65, 95% CI = 6.93-13.43); bladder cancer (HR = 2.22, 95% CI = 1.22-4.05); and pancreatic cancer (HR = 2.03, 95%CI: 1.05-3.95). Among lifelong ≤10 CPD smokers, former smokers had lower risks of smoking-related cancer with longer time since cessation and longer smoking duration. Lifelong <1 and 1-10 CPD smokers are at increased risk of incident cancer relative to never smokers and would benefit from cessation, providing further evidence that even low-levels of cigarette smoking cause cancer.
Communicating and Disseminating Research Findings

This chapter provides guidance on approaches and best practices for communicating and disseminating research findings to technical audiences via scholarly publications such as peer-reviewed journal articles, abstracts, technical reports, books and book chapters. We also discuss approaches for communicating findings to more general audiences via newspaper and magazine articles and highlight best practices for designing effective figures that explain and support the research findings that are presented in scientific and general audience publications. Research findings may also be presented verbally to educate, change perceptions and attitudes, or influence policy and resource management. Key topics include simple steps for giving effective presentations and best practices for designing slide text and graphics, posters and handouts. Websites and social media are increasingly important mechanisms for communicating science. We discuss forms of commonly used social media, identify simple steps for effectively using social media, and highlight ways to track and understand your social media and overall research impact using various metrics and altmetrics.
Multidisciplinary Clinic Management of Head and Neck Cancer.

Importance Contemporary management of head and neck cancer involves professionals from multiple specializations. Streamlined care that reduces delays yet allows for comprehensive evaluation is needed. Objective To evaluate a single-day, single-appointment, multidisciplinary head and neck clinic model for reduction in treatment delay and comprehensiveness of care. Design, Setting, and Participants A retrospective cohort analysis was conducted from June 1, 2015, to July 31, 2016, of outpatients at a single, academic medical center. All eligible outpatients seen in either the multiple-appointment, traditional clinic (n = 73) or the single-day multidisciplinary clinic (MDC) (n = 68) were included. Patients with new squamous cell carcinoma of the oropharynx, hypopharynx, sinonasal tract, and larynx, along with any mucosal site recurrence were eligible for the study. Main Outcomes and Measures Primary outcomes were delays between tertiary clinic referral or first appointment and treatment initiation in the MDC compared with the traditional clinic. Secondary outcomes were complete evaluations prior to treatment, enrollment in trials and registries, and rate of patient leak, defined as initiating therapy and then transferring to another center before completion. Outcome selection and hypothesis generation were performed a priori. Results Patient factors and tumor characteristics were similar between the traditional clinic cohort (19 women and 54 men; mean [SD] age, 64.0 [10.2] years) and the MDC cohort (8 women and 60 men; mean [SD] age, 61.0 [8.9] years). The MDC cohort had significantly fewer instances of delay greater than 30 days from referral to treatment initiation (28 [41%] vs 43 [59%]) and first appointment to treatment initiation (7 [10%] vs 17 [23%]). Actual median days in these categories were significantly different between the 2 clinic types after the patients in the traditional clinic who saw only a surgeon before treatment initiation were excluded (MDC, 28 days vs traditional, 35 days; median difference, –5 days; 95% CI, –11 to –1). Conclusions and Relevance Coordination of the management of head and neck cancer is complex. Treatment is time sensitive, and frequently clinician resources are limited. This MDC model was associated with improved efficiency and completeness of care.
Some Basic Inequalities

The usual approach to asymptotic problems relies on a large list of inequalities, and so does the present approach. This Chapter is not intended to begin with a selected list of such inequalities, but only to point out a few which are directly relevant to relations between properties of likelihood ratios and properties of the underlying measures. Of course, we shall freely use other classical inequalities such as Holder’s inequality which says that logarithm of the Hellinger transform (Chapter 3) is a convex function.
The PDE Method for the Analysis of Randomized Load Balancing Networks

We introduce a new framework for the analysis of large-scale load balancing networks with general service time distributions, motivated by applications in server farms, distributed memory machines, cloud computing and communication systems. For a parallel server network using the so-called $SQ(d)$ load balancing routing policy, we use a novel representation for the state of the system and identify its fluid limit, when the number of servers goes to infinity and the arrival rate per server tends to a constant. The fluid limit is characterized as the unique solution to a countable system of coupled partial differential equations (PDE), which serve to approximate transient Quality of Service parameters such as the expected virtual waiting time and queue length distribution. In the special case when the service time distribution is exponential, our method recovers the well-known ordinary differential equation characterization of the fluid limit.Furthermore, we develop a numerical scheme to solve the PDE, and demonstrate the efficacy of the PDE approximation by comparing it with Monte Carlo simulations. We also illustrate how the PDE can be used to gain insight into the performance of large networks in practical scenarios by analyzing relaxation times in a backlogged network. In particular, our numerical approximation of the PDE uncovers two interesting properties of relaxation times under the SQ(2) algorithm. Firstly, when the service time distribution is Pareto with unit mean, the relaxation time decreases as the tail becomes heavier. This is a priori counterintuitive given that for the Pareto distribution, heavier tails have been shown to lead to worse tail behavior in equilibrium. Secondly, for unit mean light-tailed service distributions such as the Weibull and lognormal, the relaxation time decreases as the variance increases. This is in contrast to the behavior observed under random routing, where the relaxation time increases with increase in variance.
UTSA-16 Growth within 3D-Printed Co-Kaolin Monoliths with High Selectivity for CO2/CH4, CO2/N2, and CO2/H2 Separation

Honeycomb monoliths loaded with metal–organic frameworks (MOFs) are highly desirable adsorption contactors because of their low-pressure drop, rapid mass-transfer kinetics, and high-adsorption capa...
Measures of People's Beliefs About Knowledge and Learning

Different measures of people's beliefs about the nature of knowledge and learning are described along with the theories upon which they are based. The initial theories tended to be unidimensional developmental theories and their measuring instruments lengthy, in-depth interviews. More recently, multidimensional theories have emerged that provide a more complex theory of epistemology. Recent measuring instruments are attempting to address these complexities using paper-and-pencil questionnaires that are easy to score. The measuring instruments differ considerably on what dimensions they measure and researchers are urged to select carefully the one that best matches their purpose. Specific descriptive information is provided regarding selected instruments to aid researchers in their choices. Both theory and psychometric properties are considered critical issues for the decision-making process.
Coarse-scale Modeling of Flow in Gas-injection Processes for Enhanced Oil Recovery

Subsurface formations that arise in the simulation of gas-injection processes for enhanced oil recovery may exhibit geometrically complex features with complicated large-scale connectivity. They must be included in simulations of flow and transport because they can fundamentally impact simulation results. However, to reduce computational costs, simulations are generally performed on grids that are coarse compared to the given geocellular grids, so accurate upscaling is required. In this work we are concerned with transmissibility upscaling. In the presence of full-tensor effects, multi-point flux approximations (MPFA) are desirable for the sake of accuracy, as opposed to two-point flux approximations (TPFA). However, MPFA methods add computational costs and may suffer from non-monotonicity (see [NAE06]). In [LGM06], Variable Compact Multi-Point (VCMP) upscaling was introduced. This method constructs a local MPFA that accommodates full-tensor anisotropy, and guarantees a monotone pressure solution (see [GLM06]). While it has been demonstrated that VCMP performs quite well, compared to other upscaling methods, it does not perform as well for highly channelized domains that are likely to arise in the simulation of gas injection processes. In this paper, we consider some modifications to VCMP in order to improve its accuracy for such cases. The general design of the VCMP methods is summarized in section 2. In Section 3, we present strategies for improving the accuracy and/or efficiency of VCMP. We discuss the results and future directions in section 4.
Bleeding problems in hepato-biliary patients

Acute and chronic liver disease can be associated with significant hemostatic abnormalities that may contribute to an intraoperative and/or postoperative bleeding problem. The majority of patients with acute hepatitis do not have a marked abnormality in any of the hemostatic factors. By contrast, abnormal coagulation tests may be associated with subacute hepatitis but rarely is there consequent significant bleeding. Fulminant hepatitis may be associated with hemorrhagic symptoms due to a reduced level of Factor VII that has a short biologic half life of 5 hours. Also DIC may occur as a consequence of: 1) activation of blood coagulation by release of necrotic hepatic tissue into the circulation or, 2) impaired hepatic removal of activated clotting factors, or 3) decreased levels of antithrombin III. But the issue of DIC in fulminant hepatitis is not resolved and intravascular microthrombi are rarely found at autopsy.
Photoinduced Plasmon-Driven Chemistry in trans-1,2-Bis(4-pyridyl)ethylene Gold Nanosphere Oligomers

Continuous wave (CW) pump–probe surface-enhanced Raman spectroscopy (SERS) is used to examine a range of plasmon-driven chemical behavior in the molecular SERS signal of trans-1,2-bis(4-pyridyl)ethylene (BPE) adsorbed on individual Au nanosphere oligomers (viz., dimers, trimers, tetramers, etc.). Well-defined new transient modes are caused by high fluence CW pumping at 532 nm and are monitored on the seconds time scale using a low intensity CW probe field at 785 nm. Comparison of time-dependent density functional theory (TD-DFT) calculations with the experimental data leads to the conclusion that three independent chemical processes are operative: (1) plasmon-driven electron transfer to form the BPE anion radical; (2) BPE hopping between two adsorption sites; and (3) trans-to-cis-BPE isomerization. Resonance Raman and electron paramagnetic resonance (EPR) spectroscopy measurements provide further substantiation for the observation of an anion radical species formed via a plasmon-driven electron transfer r...
The multidisciplinary pediatric psycho-oncology workforce: A national report on supervision for staff and training opportunities.

Objective This paper presents data on licensure/certification status, supervision of multidisciplinary pediatric psychosocial staff, and training opportunities in pediatric cancer programs in the United States, data that are critical to provide care aligned with the Standards of Psychosocial Care in Pediatric Cancer (Psychosocial Standards). Methods An online survey of psychosocial care consistent with the Psychosocial Standards was completed from a national sample of pediatric cancer programs (144/200). Licensure/certification status, availability and format of supervision for multidisciplinary staff (social workers, psychologists, psychiatrists, child life specialists/recreational therapists), and types and number of psychosocial trainees were reported. Results Nearly all pediatric psychosocial providers were licensed/certified. Peer consultation was the most frequently endorsed form of staff supervision although a sizeable group of centers reported no systematic ongoing supervision. Trainees in social work and child life were most common although the size of trainee cohorts is generally small. Psychosocial trainees are more prevalent in sites with pediatric hematology/oncology medical fellowship programs and in larger programs. Conclusions A properly trained and supported psychosocial workforce is essential to providing evidence-based care consistent with the Psychosocial Standards. Psychosocial providers are appropriately licensed. However, supervision opportunities are variable and may be inadequate for the intensity of the work. It is important to address the limited opportunities for trainees in pediatric cancer programs, which may influence the pipeline for ongoing and future work in this area.
A Robust Hybrid Electromagnetic Solver for Electrically Large Problems

This paper presents a multi-region hybrid solver for solving real-life challenging problems. The method provides a systematic approach based on domain decomposition to integrate various electromagnetic solvers into one powerful hybrid solver. In this work, we have combined finite element-boundary integral method, method of moments for both metallic and dielectric structures, and asymptotic high frequency methods such as physical optics and shooting and bouncing rays.
Is Anacetrapib Better Than Its CETP Inhibitor Counterparts

Cholesterol metabolism and transport has been a major focus in cardiovascular disease risk modification over the past several decades. Hydroxymethylglutaryl-CoA reductase inhibitors (statins) have been the most commonly used agents, with the greatest benefit in reducing both the primary and secondary risks of cardiovascular disease. However, heart disease remains the leading cause of death in both men and women in the United States. Further investigation and intervention are required to further reduce the risk for cardiovascular disease and cardiovascular-related deaths. This review will focus on high-density lipoprotein metabolism and transport, looking particularly at cholesteryl ester transfer protein (CETP) inhibitors. While studies of the other CETP inhibitors in its class have not shown a significant improvement in the prevention of primary or secondary cardiovascular risk, anacetrapib, the fourth and latest of the CETP inhibitors to be investigated, may be more promising.
Three-dimensional conditional hyperbolic quadrature method of moments

Abstract The conditional hyperbolic quadrature method of moments (CHyQMOM) was introduced by Fox et al. [19] to reconstruct 1- and 2-D velocity distribution functions (VDF) from a finite set of integer moments. The reconstructed VDF takes the form of a sum of weighted Dirac delta functions in velocity phase space, and provides a hyperbolic closure for the spatial flux term in the corresponding moment equations derived from a kinetic equation for the 3-D VDF. Here, CHyQMOM is extended for 3-D velocity phase space using the modified conditional quadrature method of moments with 16 (or 23) trivariate velocity moments up to fourth order. In order to verify the numerical implementation, it is applied to simulate several canonical particle-laden flows including crossing jets, cluster-induced turbulence (CIT), and vertical channel flow. The numerical results are compared with those from Euler–Lagrange simulations and two other quadrature-based moment methods, namely, anisotropic Gaussian (AG) and 8-node tensor-product (TP) quadrature. The relative advantages and disadvantages of each method are discussed. The crossing-jet problem highlights that CHyQMOM handles particle crossing more accurately than AG. For CIT, the results from all methods are similar, but the computational cost of TP is significantly larger than AG and CHyQMOM, both of which have nearly the same cost.
Henry Stapp and the Orthodox Interpretation

Henry Stapp studied with the founders of quantum mechanics and has been one of the most forceful defenders of a version of what is known as the orthodox interpretation. Upon completion of his PhD under Emilio Segre and Owen Chamberlain, Stapp was invited to work with Pauli, who unfortunately died prematurely the same year. Stapp was then invited to work with Werner Heisenberg, and then with J. A. Wheeler, on the foundations of quantum mechanics—one of the main topics on which Stapp has focused his remarkable career. These facts alone make Henry Stapp an icon in the field of physics, particularly the foundations of physics, but there is a lot more to say about Stapp and his work. In this paper, we discuss Stapp’s legacy, as well as his views about the connection between the observer, quantum measurements, and the mind/body problem.
Technologies of the Social: Family Constellation Therapy and the Remodeling of Relational Selfhood in China and Mexico

In this article, we investigate how an increasingly popular therapeutic modality, family constellation therapy (FCT), functions simultaneously as a technology of the self (Foucault, Technologies of the self: a seminar with Michel Foucault, University of Massachusetts Press, Amherst, 1988) as well as what we here call a “technology of the social.” In FCT, the self is understood as an assemblage of ancestral relationships that often creates problems in the present day. Healing this multi-generational self involves identifying and correcting hidden family dynamics in high-intensity group sessions where other participants represent the focus client and his/her family members, both alive and deceased. Drawing on ethnographic data collected in multiple FCT workshops in Beijing, China and Oaxaca City, Mexico, we show how FCT ritually reorganizes boundaries between self and other in novel ways, creating a collective space for shared moral reflection on troubling social, historical, and cultural patterns. By demonstrating the ways in which FCT unfolds as both a personal and social technology, this article contributes to ongoing conversations about how to effectively theorize sociality in therapeutic practice, and problematizes critical approaches emphasizing governmentality and commensuration (Mattingly, Moral laboratories family peril and the struggle for a good life, University of California Press, Oakland, 2014; Duncan, Transforming therapy: mental health practice and cultural change in Mexico, Vanderbilt University Press, Nashville, 2018; Matza, Shock therapy: psychology, precarity, and well-being in postsocialist Russia, Duke University Press, Durham, 2018; Pritzker, Presented at “Living Well in China” Conference, Irvine, CA, 2018; Mattingly, Anthropol Theory, 2019; Zigon, “HIV is God’s Blessing”: rehabilitating morality in neoliberal Russia, University of California Press, Berkeley, 2011).
Future Visions of Dominican History in Odilius Vlak’s Crónicas historiológicas

The work of science fiction writer Odilius Vlak (Azua, Dominican Republic, 1976) looks to the future to comment on the country’s past. In many of the stories that comprise the collection Cronicas historiologicas (2017), Vlak examines how history is written and remembered through the eyes of future Dominicans. In this article, I examine Vlak’s counterfactual takes on the Dominican War of Independence and the Trujillo dictatorship in the stories “Descargas de meteoritos en la batalla del 19 de marzo” and “Juegodrox platonicos.” By injecting speculative elements into such significant moments in Dominican history, Vlak critiques how histories are created, sold, and mythologized, while also highlighting the role of counter-narratives in contesting official accounts. In “Descargas de meteoritos en la batalla del 19 de marzo,” a mysteriously powerful space rock wins the Battle of Azua, and future generations are confronted with a virtual record of the violence of the Dominican War of Independence. In “Juegodrox platonicos,” future Dominicans attempt to solve the mystery of disappearing children during the Trujillo era, while the dictator enlists science fiction writers and artists to fortify his larger-than-life persona. Examining Vlak’s challenging of Dominican history opens up the possibility of studying contemporary Caribbean science fiction’s relationship to the future and the past.
Linear Accelerator-Based Fractionated Radiotherapy

The benefit of fractionated radiation therapy lies primarily in its ability to preferentially reduce tumor cell populations while sparing normal tissue. In the last 20 years, there has been substantial evolution and advancement in computing and physics technology, which has enabled a new breed of radiotherapy equipment capable of delivering fractionated radiation treatments with high precision and conformality. Investigations continue into various aspects of craniopharyngioma management, but there are currently clear historical data to support the addition of radiation in the setting of a subtotal resection or biopsy only. There exists some debate about the timing of the adjuvant radiation, but most institutions are implementing immediate adjuvant radiation rather than delaying it until recurrence. Follow-up after radiation therapy should be the responsibility of the radiation oncologist and should continue for at least 5 years.
Positivity thresholds of HbA1c assay as a screening test for diabetes mellitus in the first trimester in high-risk populations.

Objective: Both gestational diabetes mellitus (GDM) and type 2 diabetes mellitus (T2DM) are associated with increased risks of preeclampsia, macrosomia, shoulder dystocia, and irreversible brachial...
Vulnerability Assessment of Social-Smart Grids: An Algorithmic Approach

Utility providers are gradually deploying social networks as a useful addition to the Smart Grid in order to help engage consumers in energy management and efficient usage. Besides its benefits, is there any negative impact to the Smart Grid? In this paper, we investigate the vulnerability of Smart Grid when integrating into social networks, where attackers utilize misinformation propagation in social network to alter electricity customer's behavior with the goal of causing degradation to power infrastructure. Stand in both perspectives of power facility administrator and adversary, we model the vulnerability assessment of the system under an optimization problem, which enables us to provide theoretical analysis and behavior investigation of the system based on the complexity theory. As solving the problem is challenging, we propose heuristic solutions and show their efficiency on assessing the system's vulnerability in the presence of misinformation attacks. Therefore, we conclude that misinformation attacks must be considered when developing the security model for Socially-enabled Smart Grid technology and planning mitigation techniques.
Integrated Mobile Element Scanning (ME-Scan) method for identifying multiple types of polymorphic mobile element insertions

Mobile elements are ubiquitous components of mammalian genomes and constitute more than half of the human genome. Polymorphic mobile element insertions (pMEIs) are a major source of human genomic variation and are gaining research interest because of their involvement in gene expression regulation, genome integrity, and disease. Building on our previous Mobile Element Scanning (ME-Scan) protocols, we developed an integrated ME-Scan protocol to identify three major active families of human mobile elements, AluYb, L1HS, and SVA. This approach selectively amplifies insertion sites of currently active retrotransposons for Illumina sequencing. By pooling the libraries together, we can identify pMEIs from all three mobile element families in one sequencing run. To demonstrate the utility of the new ME-Scan protocol, we sequenced 12 human parent-offspring trios. Our results showed high sensitivity (> 90%) and accuracy (> 95%) of the protocol for identifying pMEIs in the human genome. In addition, we also tested the feasibility of identifying somatic insertions using the protocol. The integrated ME-Scan protocol is a cost-effective way to identify novel pMEIs in the human genome. In addition, by developing the protocol to detect three mobile element families, we demonstrate the flexibility of the ME-Scan protocol. We present instructions for the library design, a sequencing protocol, and a computational pipeline for downstream analyses as a complete framework that will allow researchers to easily adapt the ME-Scan protocol to their own projects in other genomes.
Voegelin's Soteriology and Ours

Every religion and many philosophies offer a soteriology – its own version of the human predicament and its solution. Instead, Voegelin offers a meta-soteriology allowing various worldviews to be assessed by their openness to truth. At the same time, Voegelin rejects generic (Kantian and Husserlian) philosophies of consciousness on the grounds that all experience is personal. This paper argues that, similarly, soteriology cannot be merely generic, as if there were one human predicament and a single solution for everyone. Each of us has her or her own predicament and calling. Tolstoy’s War and Peace and George Eliot’s Daniel Deronda are illuminating in this regard, as is the author’s own encounter with God and subsequent prayerful reading of the scriptures of the world’s religions. Finally, Socrates behavior in the Euthydemus provides a telling example of existential soteriology.
Responses to environmentally relevant microplastics are species-specific with dietary habit as a potential sensitivity indicator.

Abstract There is a lack of information on understanding how marine organisms respond to environmentally relevant microplastics (MP) which hampers decision making for waste management strategies. This study addresses this information gap by determining whether responses to MPs are species specific within a functional group. Benthic residing sea urchins, Psammechinus miliaris and Paracentrotus lividus were used as a case study. Psammechinus miliaris are strong omnivores with dietary intake including hard components (e.g. shell, tubeworms) and therefore likely to cope with the ingestion of MPs, while P. lividus are strong herbivores consuming softer dietary items (e.g. biofilms, algae) and therefore more likely sensitive. Responses to environmentally relevant MPs were conducted across two trials. Trial one determined the impact of short term (24 h) external exposure to storm-like sediment resuspension of MP concentrations (53 μm polyvinyl chloride (PVC) 25,000 MP L−1) compared to a control without MPs. No significant impacts were observed for both P. lividus and P. miliaris on metabolic rate or righting time, and urchins were able to remove MPs from the body surface using pedicellariae and cilia. Trial two determined the impact of medium term (2 months) ingestion of a diet laced with PVC MPs (59 μm) at an inclusion rate of 0.5% mass and a control diet (without MPs) on somatic growth and animal condition. The ingestion of MPs did not significantly impact P. miliaris but significantly reduced the alimentary index within P. lividus, indicating a compromised nutritional state. This study shows that responses to microplastics are species-specific and therefore cannot be generalized. Furthermore, feeding habit could act as a potential indicator for sensitivity to MP ingestion which will be important for impact assessments of plastic pollution and management strategies.
Afterword: The Power of the Ocean

As a graduate student in coastal geology, one does not expect to strike gas. This happened to the author in 1974 and the geologically unrelated aftermath led to an unforgettable demonstration of the power of the ocean and how this power can affect our coasts.
Attention-Based Secure Feature Extraction in Near Sensor Processing: Work-in-Progress

This paper presents a secure hardware architecture of an image sensor to accelerate feature extraction using region-level parallelism. For each logical region, the design includes a region processing unit (RPU) with an attention module (AM). The AM activates the processing in the RPU if there are no spatiotemporal redundancies. It reduces power consumption and data volume by utilizing the concepts of predictive coding. Also, every RPU has a crypto-core driven by the AM to withstand against adversaries. Simulation results show we can save 89.70% power with a significant speedup.