cssi/SciSciGPT-SciSciNet huggingface dataset:
A geometric approach to incomplete soft decision block decoding

Two soft-decision incomplete decoding rules based on geometric considerations are proposed and analyzed for binary antipodal signaling on an additive white Gaussian channel. It is seen that for high signal to noise ratios, low decoder error probabilities are attainable requiring approximately 2 dB less power than equivalent hard-decision decoding schemes without a significant loss in performance due to rejections. The incomplete decoding rules allow the implementation of a new reduced complexity decoding algorithm based on a processing loop constructed around an encoder. Initial results indicate the performance of this new decoder compares favorably with that of the ideal decoder. >
Enchanting bureaucracy: Symbolic violence and the (re)production of charismatic authority in a police apparatus

This article dissects the role of culture in securing authority relations within a militarized police apparatus. Adding structure and power to the symbolic interactionist approach to organizational...
Complete Genome Sequence of the Novel Leech Symbiont Mucinivorans hirudinis M3T

21,974bp).Apreliminaryanalysis of the draft genome after annotation by RAST identiﬁednumerous repetitive and transposable elements and phage se-quences, which hindered further assembly using available short-read methods.Because of this complexity, Paciﬁc Bioscience’s single-molecule real-time (SMRT) sequencing technology was chosen asan optimal sequencing strategy. Subsequently, the full genomewas sequenced from two libraries, one size selected greater than7 kb and the other not, using two SMRT cells for each library onthe PacBio RS II. The genome was assembled using the Hierarchi-cal Genome Assembly Process (HGAP) assembler (9) yielding asingle contig approximately 3.15 Mbp in length, which was man-uallyeditedtocircularizetheoverlappingendsofthegenome.Theﬁnal genome sequence is 3,149,227 bp and has a GC content of44.9%. Self dot plot analysis using Gepard (10) conﬁrmed thepresence of several large (1.5 kbp) sequence repeats that hadhindered the initial assembly.Functional annotation by RAST combined with manual anno-tation and curation identiﬁed 3,015 open reading frames (ORFs),39 tRNAs, and 2 complete ribosomal operons. As initially ob-served in the draft genome, more than 200 ORFs were annotatedas encoding phage and/or mobile element proteins. As expectedfor a member of the
Emotional Exhaustion in Graduate Students: The Role of Engagement, Self-Efficacy and Social Support

Graduate students, particularly those based in research intensive universities are susceptible to exhaustion. The study utilized a quantitative approach to test the impact of student engagement, self- efficacy, and social support on college students’ emotional exhaustion. A hierarchical regression approach was used for analysis. Findings demonstrated that students who were engaged, and self –efficacious were less exhausted from their studies. Social support especially from advisors was important in helping students cope with emotional exhaustion. Additionally, student engagement proved to be important as it partially mediates the advisor support- exhaustion relationship while fully mediating the self-efficacy- exhaustion relationship. Implications and suggestions for institutions of higher learning regarding intervention strategies to mitigate the exhaustion and burnout process were discussed.
Determination of the Critical Concentration of Neutrophils Required to Block Bacterial Growth in Tissues

We showed previously that the competition between bacterial killing by neutrophils and bacterial growth in stirred serum-containing suspensions could be modeled as the competition between a first-order reaction (bacterial growth) and a second-order reaction (bacterial killing by neutrophils). The model provided a useful parameter, the critical neutrophil concentration (CNC), below which bacterial concentration increased and above which it decreased, independent of the initial bacterial concentration. We report here that this model applies to neutrophil killing of bacteria in three-dimensional fibrin matrices and in rabbit dermis. We measured killing of 10(3)-10(8) colony forming units/ml Staphylococcus epidermidis by 10(5)-10(8) human neutrophils/ml in fibrin gels. The CNC was approximately 4 x 10(6) neutrophils/ml gel in the presence of normal serum and approximately 1.6 x 10(7) neutrophils/ml gel in the presence of C5-deficient serum. Application of our model to published data of others on killing of approximately 5 x 10(7) to 2 x 10(8) E. coli/ml rabbit dermis yielded CNCs from approximately 4 x 10(6) to approximately 8 x 10(6) neutrophils/ml dermis. Thus, in disparate tissues and tissuelike environments, our model fits the kinetics of bacterial killing and gives similar lower limits (CNCs) to the neutrophil concentration required to control bacterial growth.
SOCIAL AND GENETIC MONOGAMY IN TERRITORIAL AND LOOSELY COLONIAL POPULATIONS OF PHAINOPEPLA (PHAINOPEPLA NITENS)

Abstract We observed courtship and copulatory behavior in two populations of Phainopeplas (Phainopepla nitens) with contrasting social systems and used multilocus DNA fingerprinting to assess rates of extrapair fertilization (EPF). Phainopeplas from both territorial and loosely colonial populations copulated infrequently (≤2 times per day). No extrapair copulations (EPCs) were observed in either population. We found no evidence of EPFs in 48 nestlings from 25 nests. Thus, Phainopeplas appear to be both socially and genetically monogamous. However, Phainopeplas are not monogamous over their lifetimes—they do not retain mates from year to year and appear to switch mates between breeding localities within the same year. Compressed breeding seasons, geographically shifting food resources, and widespread breeding failures may favor monogamy during any given breeding attempt while allowing opportunities to switch mates between breeding localities and years.
The Connection of Sum Rule and Branching Ratio Analyses of Magnetic X-Ray Circular Dichroism in 3d Systems

In the recent past, Carra, et al. derived a sum rule for electric dipole transitions in a single ion model that could be used to extract an elementally-specific spin-magnetic-moment (μSPIN) from magnetic x-ray circular dichroism (MXCD) spectra. Earlier, we proposed the utilization of a branching ratio analysis for the determination of μSPIN, based upon a simplified oneelectron, atomic picture which assumed complete orbital quenching. Here, it will be shown that these two approaches are essentially related in the case of 3d ferromagnetic materials. Both methods are based upon a comparison of the integrated intensity in the L3(J=3/2) white line peak versus the sum of the intensities in the L3(J=3/2) and L2(J=l/2) peaks, after background removal. An error estimate will also be presented. A more complete description of our work is under preparation.
Subcortical grey matter volumes predict subsequent walking function in early multiple sclerosis.

Abstract Background Atrophy of subcortical grey matter structures has been reported to be associated with clinical measures of disability in multiple sclerosis (MS) patients. It is not clear if the degree of tissue loss in patients with very early MS is associated with changes in disability measures. Objective To study the association between subcortical grey matter structure volumes and clinical disability outcomes. Methods Relapsing MS patients within 12 months of clinical onset were enrolled in a neuroprotection trial of riluzole versus placebo with up to 36 months of follow-up and serial brain MRI and clinical assessments. MRI metrics, including thalamic, putamen, caudate, pallidum and cerebellar cortical volume, were measured by an automated, custom-made FreeSurfer pipeline. Volumes were normalized for head size. Clinical measures included EDSS, MSFC scores and its components. Mixed model regression measured time trends and associations between imaging and clinical outcomes. Results 42 patients with a mean follow-up of 30.6 months were analyzed in this study. There was a statistically significant decrease in thalamus, caudate and putamen volumes, but not cerebellar cortical and pallidum volumes during the follow-up period. Baseline thalamus, caudate and putamen volumes predicted subsequent changes in the timed 25-ft walk test ( p = 0.036) and MSFC ( p = 0.024 ). There was a trend for an association between baseline caudate volume and subsequent change in the timed 25-ft walk test ( p = 0.084). No association between baseline imaging and subsequent EDSS changes were seen. Conclusion Subcortical grey matter volumes at early stages of MS are associated with subsequent changes in disability measures.
An Ultra-Thin Hermetic Package Utilizing Electroplated Gold

This paper reports development and characterization of a novel technology for ultra-thin hermetic biocompatible packages at the wafer level and presents data demonstrating the hermeticity of the package. This technology utilizes a 3-micron thick film of gold that is electroplated over a 2-micron thick polyimide layer to completely enclose a section of an implantable system, which may contain integrated electronics. This package was implemented on an implantable probe substrate to demonstrate a future application of the technology, with a yield of 88%. This technology was further characterized through the development of an integrated saline sensor, which predicted a MTTF of 160 years when soaking in Phosphate Buffered Saline.
Efficient Inhibition of HIV Replication in the Gastrointestinal and Female Reproductive Tracts of Humanized BLT Mice by EFdA.

Background The nucleoside reverse transcriptase inhibitor (NRTI) 4'-ethynyl-2-fluoro-2'-deoxyadenosine (EFdA) in preclinical development exhibits improved safety and antiviral activity profiles with minimal drug resistance compared to approved NRTIs. However, the systemic antiviral efficacy of EFdA has not been fully evaluated. In this study, we utilized bone marrow/liver/thymus (BLT) humanized mice to investigate the systemic effect of EFdA treatment on HIV replication and CD4+ T cell depletion in the peripheral blood (PB) and tissues. In particular, we performed a comprehensive analysis of the female reproductive tract (FRT) and gastrointestinal (GI) tract, major sites of transmission, viral replication, and CD4+ T cell depletion and where some current antiretroviral drugs have a sub-optimal effect. Results EFdA treatment resulted in reduction of HIV-RNA in PB to undetectable levels in the majority of treated mice by 3 weeks post-treatment. HIV-RNA levels in cervicovaginal lavage of EFdA-treated BLT mice also declined to undetectable levels demonstrating strong penetration of EFdA into the FRT. Our results also demonstrate a strong systemic suppression of HIV replication in all tissues analyzed. In particular, we observed more than a 2-log difference in HIV-RNA levels in the GI tract and FRT of EFdA-treated BLT mice compared to untreated HIV-infected control mice. In addition, HIV-RNA was also significantly lower in the lymph nodes, liver, lung, spleen of EFdA-treated BLT mice compared to untreated HIV-infected control mice. Furthermore, EFdA treatment prevented the depletion of CD4+ T cells in the PB, mucosal tissues and lymphoid tissues. Conclusion Our findings indicate that EFdA is highly effective in controlling viral replication and preserving CD4+ T cells in particular with high efficiency in the GI and FRT tract. Thus, EFdA represents a strong potential candidate for further development as a part of antiretroviral therapy regimens.
Irish Language Discourses in the Republic of Ireland

Efforts to revive the Irish language diverged after the partition of Ireland in 1921, as did the sociopolitical context in which the revival was situated. Since language takes its meaning from particular historical, political and social situations, the meanings associated with the language began to change as well, along with its political significance and its role as part of the identity of Irish people north and south of the border. Discourses on the Irish language both north and south of the border share the same historical roots and in some instances have become linked to the same ideologies, but they have developed along different trajectories post-partition.
Comparison of Burnett, super-Burnett and Monte Carlo solutions for hypersonic shock structure

The continuum Navier-Stokes, Burnett, and super-Burnett equations are solved for one-dimensional shock structures in various monoatomic gases. Solutions for a hard sphere gas, argon, and a Maxwellian gas from Mach 1.3 to Mach 50 are obtained. A numerical method utilizing the complete time-dependent continuum equations and obtaining the steady-state shock structure by allowing the system to relax from arbitrary initial conditions is employed. Shock density, velocity, temperature, and entropy profiles are also obtained using the direct simulation Monte Carlo method, and these results are used as bases for comparison for continuum solution profiles. It is shown that the Burnett equations yield shock structure solutions in much closer agreement to both Monte Carlo and experimental results than do the Navier-Stokes equations. Solutions to the super-Burnett equations with coefficients as presently derived, however, are considered to be inferior to those of the Burnett equations.
VORTEX MOTIONS AND THEIR STABILITY

Publisher Summary This chapter explores vortex motions and their stability. It discusses the studies examining periodical steady-state solutions of certain vortex motions in the plane. These solutions are expressed by means of the conformal mapping Φ of the exterior of the unit disk onto the exterior of a region of constant vorticity (vortex). The vortex is subject to strain and uniform rotation. The study demonstrates the existence of some of these steady states by bifurcating the trivial solution of the circle. These solutions contain the well-known elliptical vortex of Kirchoff. This chapter presents an effective condition for the stability of these steady states. The condition of stability presented in this chapter is formulated in terms of the positive definiteness of a self-adjoint operator in the space of complex sequences l2. This chapter discusses univalent functions.
Linguistic and socio-cognitive predictors of school-age children’s narrative evaluations about jealousy:

This study investigated children’s narrative evaluations about jealousy in relation to performance on a higher-order perspective-taking task and assessments of receptive vocabulary and nonverbal in...
Peripheral nerve sheath tumors of the breast

Benign and malignant peripheral nerve sheath tumors can involve the breast, presenting as masses in the dermis, deep breast parenchyma or axillary soft tissue. Although the histologic features are frequently characteristic, diagnosis can be challenging on core needle biopsy, and the differential diagnosis includes a variety of other benign and malignant spindle cell lesions of the breast. Here, we review the key clinical and pathological features of breast schwannoma, neurofibroma, granular cell tumor, and malignant peripheral nerve sheath tumor.
G protein-coupled receptor kinases: Past, present and future

This review is provided in recognition of the extensive contributions of Dr. Robert J. Lefkowitz to the G protein-coupled receptor (GPCR) field and to celebrate his 75th birthday. Since one of the authors trained with Bob in the 80s, we provide a history of work done in the Lefkowitz lab during the 80s that focused on dissecting the mechanisms that regulate GPCR signaling, with a particular emphasis on the GPCR kinases (GRKs). In addition, we highlight structure/function characteristics of GRK interaction with GPCRs as well as a review of two recent reports that provide a molecular model for GRK-GPCR interaction. Finally, we offer our perspective on some future studies that we believe will drive this field.
Emergency department visits and readmissions within 1 year of bariatric surgery: A statewide analysis using hospital discharge records.

Background Data are limited regarding emergency department visits and readmission rates beyond 30 days after bariatric surgery. We analyzed emergency department visits and readmissions to all facilities in Wisconsin within 1 year of bariatric surgery and identified their predictors. Methods All adults who underwent a laparoscopic Roux-en-Y gastric bypass or sleeve gastrectomy from 2011–2014 were identified. Bivariate associations between patient/hospital factors and emergency department visits/readmissions were examined, and factors significant at P Results Within 1 year of bariatric surgery, 36.9% of emergency department visits and 60.3% of readmissions were to the same institution in which bariatric surgery was performed. The frequency of emergency department visits ranged from 10.7% (postoperative days 0–30) to 5.7% (postoperative days 181–270). Readmission rates ranged from 4.4% (postoperative days 0–30) to 2.7% (postoperative days 91–180). Readmission within 1 year was associated with male sex, Roux-en-Y gastric bypass, ≥4 comorbidities, Medicare insurance, teaching hospitals, and inpatient complications (all P Conclusion Emergency department visits and readmissions persist throughout the first year at a relatively steady rate after 30 days and often do not occur where bariatric surgery was performed. Quality improvement efforts targeting these patients may improve outcomes and decrease hospital resource utilization.
Driving and aging.

Driving represents a major tangible representation of independence for the elderly. People tend to think of driving as an inherent right. In fact, it is a complicated and potentially fatal activity that must be regulated and monitored. Although individuals over 70 years of age drive fewer miles, the chance of an accident per mile driven is higher because of the multiple changes related to aging. Those changes include decreased sensory perception, slowed information processing, and changes in motor performance. Most states presently do not require increased frequency of license renewal for the older driver, nor do they include periodic retesting using a written examination and road test. The laws regarding such retesting are in a state of change. Screening tests for driving safety must be revised. They should include vision and motor performance testing that is related to driving performance, based on current and continuing research. A field test should be included for drivers over 70 years of age, with a license renewal every 24 months. The physician is in a powerful position regarding surveillance of unsafe drivers. A difficult ethical decision may arise, however, involving a breach in the confidential physician/patient relationship, which must be weighed against the desire to protect society. Legislation regarding physician immunity needs to be clarified. There are many unsafe older drivers who should have their driving limited or their driver's licenses cancelled. However, we also must protect the rights of the older individuals who are safe drivers.
Studying the Crime Problem with NIBRS Data: Current Uses and Future Trends

Since 1930, the Federal Bureau of Investigation (FBI) through its national Uniform Crime Reporting Program (UCR) has collected mainly aggregate counts of crime from state and local law enforcement agencies. This focus limits the official crime data available for analysis and policy making because, with the exception of homicides,1 characteristics of specific incidents are unknown. Information such as crime location, use of weapons, type of property stolen as well as victim and offender demographics provides a more complete picture of crime and crime patterns. Such details enable assessment of both current policies aimed to reduce crime and posited theories generated to explain it. Prompted by more sophisticated studies and understandings of crime as well as improved technological capabilities to capture and transmit incident information, the FBI instituted fundamental changes in the late 1980s for how the UCR would collect crime data (FBI, 2004). Currently the UCR is in the midst of undergoing this substantial conversion from its traditional summary-based system (the summary reporting system) to its new incident-based one, the National Incident-Based Reporting System (NIBRS).
Development of an impedance-based interdigitated biochemical sensor using a multiuser silicon process

An impedance-based interdigitated biochemical sensor is presented in this work that is designed for, and fabricated using a standard polycrystalline silicon process. The sensor provides a near real time, non-invasive, label free and rapid detection technique to quantify chemicals and biomarkers in aqueous solutions. The combination of sensor structure and aqueous solution creates an equivalent electrical circuit comprised of constant and variable capacitive and resistive elements such as solution resistance and double-layer capacitance formed at the interface of the electrodes surface and the solution. The equivalent circuit and its elements are used to quantify the concentration of chemicals in an aqueous solution using the impedance of the system. Diethylhexyl phthalate (DEHP) solution is utilized to characterize and analyze the sensor's response via electrochemical impedance spectroscopy (EIS). Finite element analysis (FEA) and experimental data are used to determine the components of the equivalent circuit. The experimental results show that the sensor is able to detect the concentration of DEHP as low as 0.02 ppm. Using the circuit model and experimental data, the change of double-layer capacitance and solution resistance of the system for different solution concentrations are obtained. The results show that the double-layer capacitance increases with solution concentration, while the solution resistance decreases. The experimental results also verify the electrical circuit model used for the sensing system.
ENDOTHELIN-1 LEVEL IN HEART FAILURE WITH PRESERVED EJECTION FRACTION WITH PULMONARY HYPERTENSION VERSUS PULMONARY ARTERIAL HYPERTENSION BOTH AT REST AND AT PEAK EXERCISE

Endothelin-1 (ET-1), a potent vasoconstrictor, is elevated in heart failure as well as in pulmonary arterial hypertension (PAH). Heart failure with preserved EF (HFpEF) is the most common cause of pulmonary hypertension (D-PH). To date, there is no known level of ET-1 in rest and exercise conditions
A Root-Mean-Square Approach for Predicting Fatigue Crack Growth under Random Loading

A method for predicting fatigue crack growth under random loading which employs the concept of Barsom (1976) is presented. In accordance with this method, the loading history for each specimen is analyzed to determine the root-mean-square maximum and minimum stresses, and the predictions are made by assuming the tests have been conducted under constant-amplitude loading at the root-mean-square maximum and minimum levels. The procedure requires a simple computer program and a desk-top computer. For the eleven predictions made, the ratios of the predicted lives to the test lives ranged from 2.13 to 0.82, which is a good result, considering that the normal scatter in the fatigue-crack-growth rates may range from a factor of two to four under identical loading conditions.
A Message and Mission Statement From the New Editor-in-Chief

I Am deeply humbled to be selected to serve as the Editor-in-Chief (EiC) of the IEEE Transactions on Wireless Communications (TWireless). I wholeheartedly hope to validate the Steering Committee’s decision and the confidence placed in me by IEEE Communication Society President Khaled B. Letaief, President-Elect Vincent W.S. Chan, and Signal Processing Society President Ali Sayed in confirming the Steering Committee’s recommendation.
Gaussian process post-processing for particle tracking velocimetry.

Particle tracking velocimetry (PTV) gives quantitative estimates of fluid flow velocities from images. But particle tracking is a complicated problem, and it often produces results that need substantial post-processing. We propose a novel Gaussian process regression-based post-processing step for PTV: The method smooths (“denoises”) and densely interpolates velocity estimates while rejecting track irregularities. The method works under a large range of particle densities and fluid velocities. In addition, the method calculates standard deviances (error bars) for the velocity estimates, opening the possibility of propagating the standard deviances through subsequent processing and analysis. The accuracy of the method is experimentally evaluated using Optical Coherence Tomography images of particles in laminar flow in a pipe phantom. Following this, the method is used to quantify cilia-driven fluid flow and vorticity patterns in a developing Xenopus embryo.
Error Propagation of Satellite-Rainfall in Flood Prediction Applications over Complex Terrain: A Case Study in Northeastern Italy

The study presented in this chapter evaluates the use of satellite rainfall for flood prediction applications in complex terrain basins. It focuses on a major flood event that occurred in October 1996 in a complex terrain basin of the northeastern region of Italy. A satellite rainfall error model is calibrated and used to generate rainfall ensembles based on two different satellite products and spatio-temporal resolutions. The generated ensembles are propagated through a distributed hydrologic model to simulate the hydrologic response. The resulted hydrographs are compared against the hydrograph obtained by using high-resolution radar-rainfall as the “reference” rainfall input. The error propagation of rainfall to stream runoff is evaluated for a number of basin scales that range from 100 to 1200 km2. The results from this study show that (i) use of satellite-rainfall for flood prediction depends strongly on the scale of application (catchment area) and the satellite product resolution, (ii) different satellite products perform differently in terms of hydrologic error propagation and (iii) the propagation of error depends on the basin size; for example, this study shows that small watersheds (< 400 km2) exhibit a higher ability in dampening the error from rainfall-to-runoff than larger size watersheds.
Argumentation Tactics and Public Deliberations

This article examines how elected officials, public administrators, and the public use argumentation tactics to influence policies in public meetings. We use Habermas’s communicative rationality an...
A fast implicit solver for semiconductor models in one space dimension

Abstract Several different approaches are proposed for solving fully implicit discretizations of a simplified Boltzmann-Poisson system with a linear relaxation-type collision kernel. This system models the evolution of free electrons in semiconductor devices under a low-density assumption. At each implicit time step, the discretized system is formulated as a fixed-point problem, which can then be solved with a variety of methods. A key algorithmic component in all the approaches considered here is a recently developed sweeping algorithm for Vlasov-Poisson systems. A synthetic acceleration scheme has been implemented to accelerate the convergence of iterative solvers by using the solution to a drift-diffusion equation as a preconditioner. The performance of four iterative solvers and their accelerated variants has been compared on problems modeling semiconductor devices with various electron mean-free-path.
Real-fluid effects on standing-wave thermoacoustic instability

We have performed high-order compressible Navier–Stokes simulations of a thermoacoustically unstable resonator employing , the increase of the acoustic power produced, but also of the heat input required, for thermodynamic conditions approaching the critical point. Finally, intense mass transport events at transcritical conditions are shown to entail thermodynamic and convective nonlinearities, which do not, however, govern the limit cycle physics, dominated instead by nonlinear minor losses.
Propensity score adjusted analysis of patients with isolated locoregional recurrence versus de novo locally advanced NSCLC treated with definitive therapy.

Abstract Objectives Definitive intent treatment of isolated locoregional recurrence (iLR) for non-small cell lung cancer (NSCLC) is becoming more common. This study explores outcomes associated with the definitive local treatment of iLR and compares these outcomes to newly diagnosed locally advanced NSCLC (LA-NSCLC) patients. Materials and methods Patients with NSCLC treated with curative therapy between 2008 and 2019 at a tertiary academic institution were screened for iLR treated with subsequent definitive salvage therapy. Progression free survival (PFS), time to distant metastasis (TTDM), and overall survival (OS) were calculated via Kaplan–Meier methodology. Clinical outcomes were compared to a separate group of patients with de novo LA-NSCLC after adjusting for propensity score (PS). Results Sixty five cases of definitively salvaged iLR were compared to 302 patients with de novo LA-NSCLC. Most patients were treated with chemoradiotherapy (83.1% in iLR, 74.5% in LA-NSCLC). The median PFS, TTDM, and OS for the iLR cohort was 16.7 months (95% CI: 9.6–24.7), 35.8 months (95% CI: 17.1-NR), and 49.5 months (95% CI: 30.1-NR), respectively. After adjusting for PS, the iLR group was no different from the LA-NSCLC group in risk for progression (HR 0.78, 95% CI: 0.53–1.16, p = 0.22), distant metastasis (HR 0.81, 95% CI: 0.52–1.27, p = 0.36), or death (HR 0.90, 95% CI: 0.47–1.73, p = 0.75). Patterns of failure did not different significantly between groups. In the iLR cohort, patients with older age (HR 1.06, 95 CI: 1.01–1.10, p = 0.01) had a higher risk of death on multivariate analysis. Conclusion To our knowledge, this is the first report that compares the definitive treatment of iLR to de novo LA-NSCLC. When treated with definitive local therapy, patients with iLR had no difference in clinical outcomes from de novo LA-NSCLC. The use of curative local therapy according to a LA-NSCLC paradigm is advisable in patients with iLR of NSCLC for whom definitive therapy is feasible.
PET-detected asymptomatic recurrence is associated with improved survival in recurrent cervical cancer

We aimed to examine utilization patterns of positron emission tomography scans (PET or PET/CT) beyond 6 months after cervical cancer treatment. We investigated survival outcomes of asymptomatic patients with PET-detected recurrence. We performed a retrospective review of 283 patients with stage IA-IVA cervical cancer treated with primary chemoradiation. The 107 patients (37.8%) with recurrence were categorized as “asymptomatic PET-detected recurrence” (n = 23) or “standard detection” (n = 84) and we compared clinical characteristics and outcomes using multivariate logistic regression analysis. Late post-treatment PET (≥ 6 months after treatment) was performed in 35.3% (n = 100). Indications for late post-treatment PET included restaging in setting of known recurrence (23.6%), follow up of prior ambiguous imaging findings (9.7%), and new symptoms or exam findings (6.7%). However, late post-treatment PET was most commonly performed outside of current imaging guidelines, in asymptomatic patients without suspicion for recurrence (60.0%), presumably for surveillance. The median time to recurrence was 12.1 months (IQR 7.3–26.6). 23 patients (21.5%) had recurrence detected late post-treatment PET while asymptomatic (n = 23/107). Patients with asymptomatic PET-detected recurrence had improved survival by 26.3 months compared to the standard detection cohort (50.3 vs 24.0 months, p = 0.0015). On multivariate analysis, predictors of survival after recurrence were presence of distant metastases at diagnosis (p = 0.010) and asymptomatic PET-detected recurrence (p = 0.039). PET imaging in asymptomatic patients beyond 6 months after treatment may have clinical benefit and warrants further study. Detection of recurrence by PET in asymptomatic patients ≥ 6 months after chemoradiation was associated with prolonged survival by more than 2 years.
Presence and Therapeutic Listening

Presence and therapeutic listening are complementary therapies that are incorporated into daily nursing practice. This article presents the nurse's role in facilitating complementary therapies of presence and therapeutic listening, barriers encountered, and the behaviors and techniques to be used. Also discussed is the impact that using presence and therapeutic listening has on patient outcomes. These interventions have the potential to significantly alter patients' perceptions of care and improve patient outcomes. Presence and therapeutic listening are vital to developing a therapeutic nurse-patient relationship. This relationship is what drives positive patient outcomes and increases overall satisfaction and quality of care.
The dictator as heuristic: Trump, Zuma, and the hazards of comparison

This essay investigates the hazards of comparing Trump and Zuma, invoking “hazard” in its negative as well as potentially positive senses. Focusing on the recurrent association of Trump with (often...
Experiential Components of Co-Curriculars: High-Impact Opportunities for Social Change and Perspective Taking Within Student Organizations

In this chapter, the authors investigate whether students' participation in the experiential components of co-curricular activities-specifically student organizations-is associated with their perspective taking and engagement in social change.
Clinical Efficacy of Olaparib in IDH1/IDH2-Mutant Mesenchymal Sarcomas

PURPOSETumors with neomorphic mutations in IDH1/2 have defective homologous recombination repair, resulting in sensitivity to poly (ADP-ribose) polymerase (PARP) inhibition. The Olaparib Combinatio...
Pre-operative Mental Health Predicts Clinically Meaningful Outcomes after Osteochondral Allograft for Cartilage Defects of the Knee: A Machine Learning Analysis:

Objectives:Fresh osteochondral allograft transplantation (OCA) is an effective method of treating symptomatic cartilage defects of the knee. This cartilage restoration technique involves the single...
Global, Social, and Historical Influences

This chapter explores global, social, and historic impact and influence in the evolution of social justice educators. Global, social, and historic events include major events occurring within and outside of the United States such as the Vietnam War, political protests in China, assassination of political activists in the US, and other events that had a global impact. The chapter examines how these events compelled the participants to critically reflect on their roles as educators in society and led them to engage in social justice activism through their work. Significantly, the chapter points to the global context as critical in educating a politically conscious and social justice oriented citizenry. It shows that one cannot be social justice oriented in isolation and without actions that mitigate social injustices. Reflection questions at the end of the chapter invite readers to identify global, social, and historic events that might have occurred during their lifetime and the kind of impact in their life that these events might have engendered. The reflection questions urge the readers to think of the events from a social justice stance by posing an overarching question of: who benefitted and who was shortchanged by the events?
Processing of late adenovirus nuclear RNA to mRNA. Kinetics of formation of intermediates and demonstration that all events are nuclear.

Abstract Expression of the major late adenovirus transcription unit (which maps between co-ordinates 16 and 99 on the genome) results in the production of five distinct poly(A)-containing RNAs, which are the initial precursors to one of five 3′ coterminal mRNA groups. These initial precursors are processed with a half-life of approximately 30 minutes after the initial poly(A) addition step, which occurs within one to two minutes after transcription of sequences at the poly(A) addition site. The nuclear precursor molecules that eventually yield the fiber mRNA were examined in detail. Four distinct nuclear poly(A)-containing RNAs with 3′ termini at 91·5 were detected. The largest species represents an unspliced molecule and the smallest is the size of the mature mRNA. The two intermediatesized species presumably represent partially spliced molecules. In addition, a precursor product relationship between the species was indicated by kinetic analyses. Finally, it would appear that all major processing steps occur in the nucleus. In the case of the mRNA group that has a 3′ terminus at 51·0, all of the mRNA species of the group were detected in mRNA that had just appeared in the cytoplasm and in approximately the same molar ratios as in samples labeled for longer.
Perspectives on the Ethics of Sociometric Research with Children: How Children, Peers, and Teachers Help to Inform the Debate

Perceptions of children and teachers were examined to address concerns regarding children's welfare following sociometric testing. Third-graders (N = 91) were interviewed; teachers also reported on each child's responses to the testing. Results indicate that children were not hurt or upset by the testing, most enjoyed the procedures, did not feel that their peers treated them any differently following the testing, and understood their research rights. There were no relations between social preference as determined by peer nominations and teacher- and self-reported responses to sociometric testing. The implications of these results for the design and implementation of careful, ethical sociometric research with children are discussed.
Environmental effects on microbial turnover of some mineral elements: Part I—Abiotic factors

Some effects of biotic factors (forest floor, microflora, litter fauna) on mineral cycling on artificial and natural substrates were measured using radionuclides. Leaching and immobilization of 134Cs in the leaves of four species of tree were positively related. During the first weeks of decay all species except mulberry showed net immobilization. In fresh litter of tulip poplar rates of leaching of 137Cs and microbial activity, as well as immobilization of 137Cs, were higher than in one-year-old litter. Mixing of litter with 137Cs and litter without 137Cs did not affect 137Cs movement. Concentration factors for Cs of several representative soil organisms in vitro and in fungal fruiting bodies in the field which derived their Cs from the substrate varied from < 0.1 to 80. The maximum concentration of 134Cs and 60Co by Trichoderma viride in shaken cultures occurred after about 5 days. A change from net immobilization to net mineralization of 137Cs by the natural flora of tulip poplar leaves occurred after 10 days of growth. Presumably ageing of microbial tissue increased release of minerals more than it did uptake which resulted in reduced immobilization in time. Mineral accumulation by long-lived fungal fruiting bodies and mycelium, however, continued for several weeks. Five millipedes on l g of entire white oak leaves tagged with 134Cs accumulated in 18 days 9% of the initial 134Cs in their tissue; reduced microbial immobilization from 24 to 11% of the initial 134Cs, presumably by reducing mycelium growth; and increased leaching from 26 to 30% of the initial 134Cs as a result of leaf fragmentation. It was concluded that biotic as well as abiotic factors greatly affect mineral turnover by the microflora. Further knowledge of such effects may open ways to control the mineral kinetics in the environment.
Faculty Committee Work

ABSTRACT Faculty committee service can make heavy demands on a social work educator's time. It reduces opportunities to meet other role expectations such as good teaching and professional scholarship-expectations that receive close scrutiny when personnel decisions about tenure, promotion or merit pay increases are made. The authors surveyed deans and directors of CSWE accredited graduate programs to examine a number of questions related to faculty committee work expectations and rewards that they carry. Data suggest that some committees exist within virtually all graduate programs and that all faculty are expected to share in committee responsibilities. Rewards and special considerations for responsible committee service are few. Other findings also are presented and discussed in relation to norms and variations that exist among graduate programs.
Coagulation abnormalities in liver disease.

The liver, the major site of production of most coagulation components, is intimately involved in the clearance of activation products. Hemostasic abnormalities relate to the extent of liver function impairment. Minor impairment may be associated with slight decreases in clotting factors, especially the vitamin Independent factors; major defects (cirrhosis) may display decreases of virtually all factors, impaired platelet function, and increased consumption (i.e., disseminated intravascular coagulation [DIC]). Liver surgery invariably leads to bleeding, most of which is caused by DIC.
A Brief History of Psychotherapy and Physical Disability

The history of psychotherapy and physical disability is reviewed. The scope of the review ranges from the early writings to contemporary findings on psychotherapy with the physically disabled. Part...
Compressive sensing based image reconstruction for synthetic aperture radar using discrete cosine transform and noiselets

Synthetic Aperture Radar (SAR) has the ability to obtain high resolution 2D imagery from distributed targets, such as landscapes. SAR image resolution is limited by the transmitted signal bandwidth and the antenna length, and also depends on the sampling rate. SAR processing is very computer-intensive since it measures and processes enormous amounts of data to obtain the target image. In this paper, we propose an alternative method using compressed sensing (CS), which is able to overcome the fast sampling and the large-scale data storage limitations. CS is also effective for reconstructing the raw image data with sparsity. For complex raw data obtained by the echo signal, compressed sensing based on l 1 -norm optimization with discrete cosine transform and noiselet processing is adopted to reconstruct the SAR image. By using fewer SAR echo signal samples with complex data, we demonstrate improved results in the SAR image reconstruction.
MEMS micro-glassblowing paradigm for wafer-level fabrication of fused silica wineglass gyroscopes

Abstract In this paper, we report latest developments in wafer-level micro-glassblowing paradigm for fabrication of highly symmetric, high Q-factor fused silica wineglass gyroscopes. Q-factors over 1 million have been demonstrated on both n = 2 wineglass modes with a high frequency symmetry (Δf/f) of 132 ppm. High Q-factor is enabled by a high aspect ratio, self-aligned glassblown stem structure, careful surface treatment of the perimeter area, and low internal loss fused silica material. Low frequency split is provided by the self-correcting behavior of the surface tension based micro-glassblowing process. Micro- glassblowing may enable batch-fabrication of high performance fused silica wineglass gyroscopes on a wafer surface at a significantly lower cost than their precision-machined macro-scale counterparts.
Classical and quantum-wedge billiards.

Abstract The wedge billiard in the plane is considered both quantum mechanically and classically. In the quantum domain, two classes of solutions emerge depending on the wedge angle θ 0 . In the first class, corresponding to vertex angles πθ 0 = s ⩾2 and integer, eigenfunctions are real-analytic in the closed domain of the wedge. Incident and reflected waves on the vertex are shown to have equal and opposite current densities. In the classical domain, it is established that only at these angles does a trajectory on the vertex of the wedge nonsingularly retroreflect from the vertex (i.e., reflects from the vertex). Furthermore, the billiard is integrable at these vertex angles. In the second class, πθ 0 ≠ s , eigenfunctions are irregular at the origin and the related classical motion is nonintegrable. Application of these results to other areas of technology is noted.
Sensitivity changes to dopaminergic agents in fine moto control of rhesus monkeys after repeated methamphetamine administration

Abstract Long-term behavioral and neurochemical effects of repeated methamphetamine (MA) administration were investigated in rhesus monkeys trained to perform a fine motor task requiring control of exerted force for a specific time. Rhesus monkeys were trained to extend their arms into a tube to press a lever with a force between 25 and 40 g for 5 sec in order to receive 1.5 ml of water. The effects of intramuscular administration of MA, apomorphine (APO) and haloperidol (HAL) on responding were compared before and after a 2-week period of repeated MA administration. During this period, MA was given in 4 divided doses starting at a total daily dose of 4 mg/kg/day and increasing to 40 mg/kg/day. Tolerance to MA, increased sensitivity to HAL and no consistent sensitivity change to APO were observed when dose-response functions were redetermined starting 1 month after the repeated MA administration. One month after these determinations were completed, the brains of the monkeys were analyzed for changes in monoamines. Significant depletions of dopamine in the caudate nucleus and serotonin in the frontal cortex were seen. It is hypothesized that the sensitivity changes to the drugs on performance were related to the dopamine depletion.
Explaining Participation in Regional Transnational Social Movement Organizations

Since the late 1980s, governments have focused intensely on formalizing political and economic relationships within regions. There has also been a concurrent rise in transnational, regional level organizing among social movement activists globally, suggesting the regionalization of `global civil society.' However, opportunities for participation in transnational associations vary widely across countries. In this article, we examine the influence of international (both global and regional) institutional contexts, citizen participation in international society, and national level factors on varying levels of participation in regional transnational social movement organizations (TSMOs). We use negative binomial regression to examine relationships among these factors at three time points: 1980, 1990, and 2000. We find that in the early time period, citizen network connections to international society facilitated the formation of and participation in regionally organized TSMOs. Over time, however, regional and...
Total light loss fiber optic spectroscopy: Progress towards a fiber optic raman organic sensor

A Raman probe has been developed utilizing a single optical fiber as both a light pipe and an active sensing element. By coating a small segment of the surface of an exposed glass fiber core with a thin polymer film, an inverted waveguide is formed where light transmitted down the fiber is stripped out of the core and into the polymer film. The polymer coating is used both as a waveguide and as a medium for concentrating small organic molecules to be interrogated by Raman spectroscopy. The ability of the fiber optic thin-film waveguide probe to detect organic vapors is demonstrated. The utility of the probe in the detection of nonaqueous phase liquids (NAPLs) is also described.
Serial Killers: Offender's Relationship to the Victim and Selected Demographics:

Currently it is generally accepted among members of the law enforcement community, forensic psychologists, criminologists and profilers that serial killers are mostly white males in their twenties ...