cssi/SciSciGPT-SciSciNet huggingface dataset:
Madness and Authority in Jacobi and Ferraris: Why New Realism Is Not New

New Realism is not new. Instead of a new response to a novel philosophical problem, New Realism is an unacknowledged resurrection of Jacobi’s criticism of philosophical rationality that ignited what is now known as the “pantheism controversy.” Both Jacobi and Ferraris argue that the antirealist epistemologies of their contemporaries displace our relation to the world to which thought is supposed to be beholden. Further, both Jacobi and Ferraris claim that the antidote to these delusional philosophical ideations is realism. Finally, both take a reactionary stance toward the renegotiation of authority that stands at the core of the Enlightenment project. If this is indeed the case, then New Realism is a repetition and not an advance. More significantly, despite its own aspirations, New Realism is a reactionary, anti- Enlightenment philosophical proposal. In short, Ferraris says “Goodbye Kant!” too quickly and for old reasons.
Low-Temperature Detectors for CMB Imaging Arrays

We review advances in low-temperature detector (LTD) arrays for cosmic microwave background (CMB) polarization experiments, with a particular emphasis on imaging arrays. We briefly motivate the science case, which has spurred a large number of independent experimental efforts. We describe the challenges associated with CMB polarization measurements, and how these challenges impact LTD design. Key aspects of an ideal CMB polarization imaging array are developed and compared to the current state of the art. These aspects include dual-polarization sensitivity, background-limited detection over a 10:1 bandwidth ratio, and frequency-independent angular responses. Although existing technology lacks all of this capability, today’s CMB imaging arrays achieve many of these ideals and are highly advanced superconducting integrated circuits. Deployed arrays map the sky with pixels that contain elements for beam formation, polarization diplexing, passband definition in multiple frequency channels, and bolometric sensing. Several detector architectures are presented. We comment on the implementation of both transition-edge sensor bolometers and microwave kinetic inductance detectors for CMB applications. Lastly, we discuss fabrication capability in the context of next-generation instruments that call for $$\sim 10^6$$ sensors.
Serotonin 6 receptor modulation reduces locomotor activity in C57BL/6J mice.

Abstract The serotonin 6 receptor (5-HT6) is a more recently identified therapeutic target for several neuropsychiatric disorders. While the 5-HT6 receptor has gained interest as a target for novel therapeutics, determining the basic sex differences is lacking in the literature. To address this, the present study examined the effects of 5-HT6 receptor modulation on locomotor activity and open field measures of anxiety in C57BL/6J mice. Female and male mice were tested after acute treatment with either 5-HT6 receptor antagonist SB 271046 or 5-HT6 receptor agonist EMD 386088. Acute 5-HT6 receptor blockade with SB 271046 attenuated locomotor activity in C57BL6/J mice, irrespective of sex. When locomotor activity was analyzed for six 10 min time blocks, 0.1, 5, or 15 mg/kg of SB 271046 reduced locomotor activity for the initial 40 min of testing, but only 5 and 15 mg/kg SB 271046 exhibited a reduction in locomotor activity for at least 60 min. EMD 386088 only attenuated locomotor activity when mice were treated with the high dose of 15 mg/kg EMD 386088. This was true for all time blocks except for the 40–50 min time block. In addition, EMD 386088 at the 15 mg/kg dose reduced locomotor activity in female mice more than males during the 20–30 and 30–40 minute time blocks. Analysis of the anxiolytic properties of 5-HT6 receptor modulation via the open field, showed that SB 271046 did not demonstrate anxiogenic properties in either sex at the doses tested. Instead, 15 mg/kg EMD 386088 produced an anxiogenic effect in both female and male mice. Together these findings highlight the differing impact of specific 5-HT6 receptor modulation on locomotor activity in C57BL/6J mice.
Patient-related outcomes of patellofemoral arthroplasty: experience of a single center

The purpose of this prospective study was to present the experience of a single center on patellofemoral arthroplasty, in terms of patient-related outcomes. From January 2005 to January 2016, 42 patients with isolated patellofemoral osteoarthritis were treated. The patients were assessed using the Oxford Knee Score preoperatively, and one, five, and eight year(s) after surgery. The data of the patients were analyzed using linear mixed effects models. A P value of 0.05 was considered statistically significant. Among 42 patients who underwent patellofemoral arthroplasty, only 25 patients (31 limbs involved) had records up to 5 years. There was a significant clinical improvement of Oxford Knee Score postoperatively (P 0.05), gender (P > 0.05), age (P < 0.05), and body mass index (BMI) (P < 0.05). Patellofemoral arthroplasty can significantly improve the knee function, and this improvement is independent of the type of implant, gender, age, and BMI. However, further studies will need to assess the long-term outcomes of PFA.
Optimization of Cellular Concrete Microstructure for Improved Impact Resistance

Engineered material arresting system (EMAS) is a cellular concrete material currently used as passive aircraft arresting system at airports around the U.S.A. and abroad. Its cellular structure crus...
Oxidative Phosphorylation Is a Metabolic Vulnerability in Chemotherapy-Resistant Triple-Negative Breast Cancer.

Oxidative phosphorylation (OXPHOS) is an active metabolic pathway in many cancers. RNA from pre-treatment biopsies from patients with triple negative breast cancer (TNBC) who received neoadjuvant chemotherapy demonstrated that the top canonical pathway associated with worse outcome was higher expression of an OXPHOS signature. In multiple TNBC patient-derived xenografts (PDXs), treatment with IACS-10759, a novel inhibitor of OXPHOS, stabilized tumor growth. Gene expression profiling revealed that all sensitive models displayed a basal-like 1 TNBC subtype, and expression of mitochondrial genes was significantly higher in sensitive PDXs. An in vivo functional genomics screen in tumors treated with IACS-10759 found several potential synthetic lethal targets, including CDK4. A combination of palbociclib, a CDK4/6 inhibitor, and IACS-10759 exhibited significant anti-tumor efficacy in vitro and in vivo. In addition, the combination of IACS-10759 and multi-kinase inhibitor cabozantinib had improved antitumor efficacy compared to either single agent. Taken together, these data suggest that OXPHOS is a metabolic vulnerability in TNBC that may be leveraged with novel therapeutics in combination regimens.
Experiments on the expansion wave driven Rayleigh-Taylor instability

The Rayleigh-Taylor (RT) [1, 2] instability occurs when a perturbed interface between two fluids of different densities is accelerated such that the pressure gradient is directed from the heavier fluid to the lighter one. The instability causes small perturbations to grow with time, rolling up into a multi-valued interface, and finally transitioning to turbulence. In contrast to previous studies, an expansionwave is used in this study to produce the pressure gradient generating the instability. This instability is of interest in astrophysics in the study of supernovae [3] as well as in inertial confinement fusion, where it impedes the initiation of thermonuclear burn [4].
TAPP vs. TEP

The two most common techniques for laparoscopic inguinal hernia repair are the transabdominal preperitoneal (TAPP) technique and the totally extraperitoneal (TEP) technique. Although in the end both techniques are used to place mesh in the preperitoneal space to cover the entire myopectineal orifice, they differ in how access to that space is obtained, and slight differences between the two approaches exist. TAPP is quicker to learn and is associated with an overall low but higher risk of visceral injury and port-site herniation. TAPP has a slight operative time advantage with no difference in hernia recurrence rate. Pain may be more a function of mesh fixation during the operation rather than technique itself. This chapter discusses the risks and benefits of each technique and compares their surgical outcomes.
Strong Approximations in Queueing Theory

Publisher Summary This chapter discusses some of the merits of strong approximation ideas in developing diffusion approximations for queueing systems. Letting ρ, be the utilization of the server, it is well known that as the queue is sent into heavy-traffic, the system can be approximated by a diffusion process on spatial scales of order (1–p) -1 and time scales of order (1–p) -2 . In this chapter, it is shown how strong approximation methods permit one to validate the applicability of the diffusion approximation to the queue over other temporal and spatial scales. In addition, some pedagogical advantages of the strong approximation approach are discussed, and two open problems for the strong approximation community are described.
Human Factors/Ergonomic Aspects of Vehicular Accident Investigation 1975 Update

This paper presents a case for the growing application of Human Factors/Ergonomic expertise to develop decisions that take place within the transportation industry. It offers a definition of the HF/ERG engineering in traffic safety, research, training, and education.
Vita-PAMPs: Signatures of Microbial Viability

Can the innate immune system detect and respond to microbial viability? Using bacteria as a model, we found that indeed the very essence of microbial infectivity, viability itself, can be detected, and notably, in the absence of the activity of virulence factors. The microbial molecule that serves as the signature of viability is bacterial messenger RNA (mRNA), common to all bacteria, and without which bacteria cannot survive. Prokaryotic mRNAs also differ from eukaryotic mRNAs in several ways, and as such, these features all fulfill the criteria, and more, for a pathogen-associated molecular pattern (PAMP) as originally proposed by Charles Janeway. Because these mRNAs are lost from dead bacteria, they belong to a special class of PAMPs, which we call vita-PAMPs. Here we discuss the possible receptors and pathways involved in the detection of bacterial mRNAs, and thus microbial viability. We also consider examples of vita-PAMPs other than bacterial mRNA.
Were Chinese Rulers above the Law? Toward a Theory of the Rule of Law in China from Early Times to 1949 CE

Scholars define the rule of law in many different ways, but they generally agree that it requires at least two elements: one, that the ruler be subject to, or at least not above, the law; and two, that the law be applied equally, or at least equitably, to all members of society. The received wisdom in both China and Euro-America is that China has lacked the rule of law because of the dominance of Confucianism, that advocates the rule of men, and Legalism, that calls for the rule by law. Through a reexamination of basic Chinese texts and a critical review of relevant scholarship in English and Chinese, this article offers a new theory regarding the origins and development of the rule of law in China from the Zhou (trad. 1122-256 BCE) through the Republic (1912-1949). We argue that, by Zhou times, the Chinese conceived of a superhuman basis - the mandate of heaven and nature - for the rule of law, and, by the Spring and Autumn and Warring States Periods, it developed various notions - including Ruist rites, Legalist laws, and even the Daoist Way - that could and did limit the authority of the ruler and increase the equity of society. From the Qin to the mid-twentieth century, Chinese rulers were expected to govern in accordance with customs and models inherited from ancestors, with laws and institutions established in cooperation with officials, and with historical norms produced over time by the interaction of heaven, earth, and humans (i.e., the cosmic process).
Association between in-hospital adverse events and mortality for patients with brain tumors.

OBJECT The Agency for Healthcare Research and Quality patient safety indicators (PSIs) and the Centers for Medicare and Medicaid Services hospital-acquired conditions (HACs) are administrative data-based metrics. The use of these outcomes as standard performance measures has been discussed in previous studies. With the objective of determining the applicability of these events as performance metrics among patients undergoing brain tumor surgery, this study had 2 aims: 1) to evaluate the association between PSIs, HACs, and in-hospital mortality rates; and 2) to determine a correlation between hospital volume, PSIs, and HACs. METHODS Patients with brain tumors treated between 1998 and 2009 were captured in the Nationwide Inpatient Sample database. Hospitals were categorized into groups according to surgical volume. Associations between PSIs, HACs, and in-hospital mortality rates were studied. Factors associated with a PSI, HAC, and mortality were evaluated in a multivariate setting. RESULTS A total of 444,7...
Mixed-Layer Deepening During Heinrich Events: A Multi-Planktonic Foraminiferal δ18O Approach

Proxies from Greenland ice cores and North Atlantic marine sediment cores document repeated extreme climate swings of a few decades to millennia during the last glacial cycle, including periods of intense ice rafting called Heinrich events (HEs). We have found similar oxygen isotope variations recorded in mixed-layer–and thermocline-dwelling planktonic foraminifera during HEs 0, 1, and 4, suggesting that three foraminiferal taxa calcified their shells at similar temperatures in a homogenized upperwater column. This implies that the surface mixed layer was deeper during HEs. Similar deepening occurred on the northern margin of the ice-rafted–debris belt, implying that these deep mixed layers during HEs were widespread in the region. We suggest that an increase in storminess during HEs intensified the vertical mixing of meltwater from ice rafting in the upper ocean.
Emotional Outlook on Life Predicts Increases in Physical Activity Among Initially Inactive Men

This study examined the relationship between emotional outlook on life and change in physical activity among inactive adults in the Aerobics Center Longitudinal Study. A total of 2,132 sedentary adults completed a baseline medical examination and returned for a follow-up examination at least 6 months later. Participants self-reported physical activity level and emotional outlook on life. Emotional outlook on life was significantly and positively related to physical activity participation at the follow-up visit in men but not women. Men who were usually very happy and optimistic at baseline had significantly greater increases in physical activity compared to men who were not happy. Men with a more positive outlook on life (e.g., happier) may be more likely to increase physical activity levels. Physical activity interventions targeting men may be more successful if they first increase happiness.
What is the best measure of maternal complications of term pregnancy: ongoing pregnancies or pregnancies delivered?

Abstract Objective The purpose of this study was to determine whether rates of hypertensive disorders of pregnancy increase beyond 37 weeks of gestation and to address how best to analyze these rates. Study design This was a retrospective cohort study of all women delivered beyond 37 weeks' gestational age from 1995 to 1999 at all Kaiser Permanente Medical Care Program delivery hospitals in Northern California. Rates of gestational hypertension, preeclampsia, and eclampsia were calculated by use of both pregnancy delivered (PD) and ongoing pregnancy (OP) as the denominator. Bivariate and multivariate analyses were conducted with use of P Results Among the 135,560 women in this cohort, the rates of gestational hypertension, preeclampsia, and eclampsia were the same or decreased from 37 to 43 weeks' gestation using PD, but all three increased when calculated according to OP ( P Conclusion We found that among complications of pregnancy that are diagnosed ante partum, use of a different denominator led to contradictory conclusions. When hypertensive disorders of pregnancy are analyzed, ongoing pregnancies should be used as the denominator.
Contributions of wild relatives of maize to the evolutionary history of domesticated maize: A synthesis of divergent hypotheses I

In this first of three sections of an attempted synthesis of the more important hypotheses concerning the manner in which domesticated maize originated, the salient features of these hypotheses are compared. The morphological and genetical evidence on which they are based is reviewed and background information concerning the archaeological evidence is presented. In the succeeding two sections archaeological discoveries relating most directly to maize origin will be evaluated and varied interpretations of their significance and that of the morphological and genetical evidence will be discussed in attempting a synthesis of currently divergent views.
Comparison of the performance of brown trout, Salmo trutta L., and rainbow trout, Oncorhynchus mykiss (Walbaum), in a put‐and‐take fishery

. Stock and catch statistics for a small (5–5ha) lowland put-and-take trout fishery have been used to investigate the relative catchability of brown, Salmo trutta L., and rainbow, Oncorhynchus mykiss (Walbaum), trout. Brown trout were consistently less vulnerable to fly fishing than rainbows, and were particularly difficult to catch between mid-June and September. As a consequence, the turn-over of rainbow trout stock was more rapid than that of brown trout, but eventual recapture levels of both species were similar at around 90% of the fish stocked. In these circumstances, brown trout could be regarded as a long-term investment for fishery managers, with rainbows providing more‘instant’sport.
The implementation of total quality management in Canada and Mexico: a case study

Abstract Total quality management (TQM) gained its popularity during the last decade and continues to have a profound impact on business strategies today. Using the case method, this research examines the influence of national culture on the successful or unsuccessful implementation of TQM in Canada and Mexico. Focused interviews are used to compare the TQM implementation process in two plants in Canada and Mexico. As hypothesized, the qualitative results suggest that a firm in a collectivistic culture, such as Mexico, is more successful at implementing TQM than a firm in an individualistic culture, such as Canada. This is because the collectivistic culture has more TQM beliefs and values than the individualistic culture. The implications of these findings for organizations in collectivistic and individualistic cultures are discussed.
The postnatal development of the motor speech area: a preliminary study.

Abstract This preliminary study follows the maturation of motor speech areas and their adjacent orofacial motor zones in the right and left hemispheres of the human infant from 3 months to 72 months of age. Quantitative studies of basilar dendrite patterns of layer 5 cortical pyramids are reported in 17 age-graded subjects. The sequence of developmental changes is characterized by early (3 month) prominence of orofacial motor zones over motor speech areas and of the right hemisphere over the left as expressed in total basilar dendritic length and the length of proximal order dendritic segments. The complex series of changes which follow appear to involve increase in number and marked increase in length of the developing distal order segments and possible shortening of the proximal segments. During a variable sequence of apparent growth spurts and resorptions, dendrite arborizations of the motor speech areas overtake and exceed those of orofacial musculature and the total length of dendrite systems on the left finally exceeds those on the right, although even in the most mature group, (42–72 months), distal segment length in the right motor speech area still exceeds that of the left. The early structural primacy of right-sided dendrite systems and the progressive shift to left-sided primacy is considered in the light of the presence of a long phylogenetic and ontogenetic history of gross anatomical asymmetry favoring the left side. The possibility that developmental patterns of the cortical macroenvironment and microenvironment may be dissociated with the microenvironment depending heavily on epigenetic factors receives support from recent data suggesting the existence of a time window or critical period during which primary language proficiency must be attained if normal lateralization of language function is to occur.
Measuring weight outcomes for obesity intervention strategies: The case of a sugar-sweetened beverage tax

Taxing unhealthy foods has been proposed as a means to improve diet and health by reducing calorie intake and raising funds to combat obesity, particularly sugar-sweetened beverages (SSBs). A growing number of studies have examined the effects of such food taxes, but few have estimated the weight-loss effects. Typically, a static model of 3500 calories for one pound of body weight is used, and the main objective of the study is to demonstrate its bias. To accomplish the objective, we estimate income-segmented beverage demand systems to examine the potential effects of a SSB tax. Elasticity estimates and a hypothetical 20 percent effective tax rate (or about 0.5 cent per ounce) are applied to beverage intake data from a nationally representative survey, and we find an average daily reduction of 34-47 calories among adults and 40-51 calories among children. The tax-induced energy reductions are translated into weight loss using both static and dynamic calorie-to-weight models. Results demonstrate that the static model significantly overestimates the weight loss from reduced energy intake by 63 percent in year one, 346 percent in year five, and 764 percent in year 10, which leads to unrealistic expectations for obesity intervention strategies. The tax is estimated to generate $5.8 billion a year in revenue and is found to be regressive, although it represents about 1 percent of household food and beverage spending.
Estimates for the temporal response characteristics of chromatic pathways

When equiluminous red and green fields are temporally alternated, it is generally accepted that the hue of the field fuses to yellow at a slower flicker rate than the critical flicker frequency (cff). However, when sufficient precautions are taken to avoid optically created achromatic artifacts and the illumination of the test field is kept fairly low (70 trolands), the modulation threshold for color fusion and that for flicker fusion are equivalent. The purely chromatic, artifact-free stimulus shows a much lower cff than has been reported in the literature under comparable conditions. It seems likely that many studies of the chromatic pathways have overestimated the ability of these pathways to follow rapid temporal alternation, presumably because the more sensitive achromatic pathways were detecting achromatic artifacts. A simple means for detecting achromatic artifacts in a temporal alternation will be demonstrated by the finding that an equiluminous surrounding field enhances modulation sensitivity only for achromatic flicker and not for chromatic flicker.
Establishing a Linkage between Phosphorus Forms in Dairy Diets, Feces, and Manures

Effective manure management to efficiently utilize organic wastes without causing environmental degradation requires a clear understanding of the transformation of P forms from diet to manure. Thus, the objective of this study was to establish quantitative relationships between P forms in diets, feces, and manures collected from U.S. Northeastern and Mid-Atlantic commercial dairy farms. Total P in diets ranged from 3.6 to 5.3 g kg(-1) dry matter, while the feces had higher P than diets (5.7-9.5 g kg(-1)) and manures had lower P (2.5-8.9 g kg(-1)) than feces. The farms with total dietary P of 4.8 to 5.3 g P kg(-1) had twofold higher concentrations of phytic acid (1647-2300 mg P kg(-1)) than farms with 3.6 to 4.0 g dietary P kg(-1) (844-1100 mg P kg(-1)). Much of the phytic acid in diets was converted to inorganic orthophosphate in the rumen as indicated by a reduction in phytic acid percentage from diets (32%) to feces (18%). The proportion of orthophosphate diesters (phospholipids, deoxyribonucleic acid [DNA]) was twice as high in feces (6.2-10%) as diets (2.4-5.3%) suggesting the excretion of microbial residues in feces. Phosphonates (aminoethyl phosphonates and phosphonolipids) were not seen in diets but were detected in feces and persisted in manures, which suggests a microbial origin. These organic compounds (phytic acid, phospholipids, DNA) were decomposed on storage of feces in slurry pits, increasing orthophosphate in manures by 9 to 12% of total P. These results suggest that reducing dietary P and typically storing feces in dairy farms will result in manure with similar chemical forms (primarily orthophosphate: 63-77%) that will be land applied. Thus, both the reduction of dietary P and storage of manure on farm are important for controlling solubility and bioavailability of P forms in soils and waters.
Cloning, expression, and characterization of a novel guanylate-binding protein, GBP3 in murine erythroid progenitor cells

AbstractWe report the molecular cloning of a novel guanylate-binding protein GBP , termed mouse GBP3 mGBP3 in Friend.  .virus-induced mouse erythroid progenitor FVA cells. The 71-kDa mGBP3 belongs to a family of known GBPs that.contain the first two consensus motifs, GXXXXGK S.  .rT and DXXG, but lack the third element, NrT KXD, found intypical GTP-binding proteins. Recombinant mGBP3 protein, expressed using a baculovirus expression system, binds toagarose-immobilized guanine nucleotides GTP, GDP and GMP . Moreover, mGBP3 has been found to have an intrinsic.GTPase activity with K and V values of 77"4 mM and 21"0.5 pmol min y1 mg y1 of protein, respectively. The mmax mGBP3 is distinct from the other GBPs, in that it does not have an isoprenylationrmethylation motif CAAX at the carboxylterminus. The mGBP3 appears to be localized in the cytosol based on immunofluorescence staining. Although the mGBP3transcript is expressed to a varying degree in numerous mouse tissues, the message is most abundant in FVA cells. ThemGBP3 transcript increases in FVA cells undergoing differentiation to a maximum within a few hours and then decreases toan undetectable level by 24 h. These results, taken together, suggest that mGBP3 is a novel member of a family ofguanylate-binding proteins, which plays a role in the erythroid differentiation. The nucleotide sequence reported in thispaper has been submitted to the GenBanke with accession number U44731. q1998 Elsevier Science B.V. All rightsreserved.
Fine root growth dynamics of four Mojave Desert shrubs as related to soil moisture and microsite

Water is generally considered to be the major limiting factor for perennial shrub growth in the Mojave Desert, USA. However, the responses of active fine roots to soil moisture and microsite differed among Ambrosia dumosa, Ephedra nevadensis, Larrea tridentata, and Lycium pallidum, suggesting differences in root foraging strategies. Ambrosia and Ephedra had a positive linear relationship between active fine root lengths and soil moisture and more roots under the canopy, whereas Larrea had a negative linear relationship and more roots in the interspace. Lycium did not show a significant root/water relationship or significant differences between canopy and interspace microsites.
Exon-Skipping Therapy: A Roadblock, Detour, or Bump in the Road?

Exon skipping is a promising therapeutic for Duchenne muscular dystrophy patients, but the road to drug approvals is foggy and may require more early-stage derisking and regulatory guidance.
Exploration of Solid-Supported Reactions with Gold Nanoparticles

A set of two laboratory experiments demonstrating application of solid-supported reactions in the field of nanotechnology is described. After learning basic techniques of solid-phase synthesis, students apply the acquired skills to the polymer-supported functionalization of gold nanoparticles. These experiments became part of the polymer workshop, conducted by the Northern Plains Undergraduate Research Center (NPURC) in May 2009.
Frequency Weighting Contours for Predicting the Speech Interfering Aspects of Noise

Physical and psychophysical schemes that purported to measure the speech interfering aspects of noise were examined in a series of papers by Klumpp & Webster (1962, 1963) and Webster & Klumpp (1963). Sixteen diverse-spectrum noises were adjusted in level so that listeners hearing monosyllabic (rhyme) words at a constant level of 78 dB from a loudspeaker obtained 50 % word intelligibility scores. Articulation index (a.i) calculations (see Kryter 1962 a ) predicted the speech-interfering properties of the noises very well. However, other, and simpler, schemes worked just as well; for example, speech interference level (s.i.l.) calculations (see Beranek 1954), based on octaves centred at 425, 850 and 1700 Hz, or 500, 1000 and 2000 Hz. The A-weighting and Din 3 networks (see Peterson & Bruel 1957), of a sound level meter (s.l.m.) were good, but the conventional use of noise criteria (n.c.), or alternate noise criteria (n.c.a.) (see Beranek 1957), curves did not work well unless (1) only that part of the curves centering on the octaves 500, 1000 and 2000 Hz was used, and (2) the noise spectra were allowed to ‘average through’ a contour and not just touch it at a peak value.
Shapes and widths of ammonia lines collision-broadened by hydrogen.

Measurement of half-widths and shapes of several rotational lines in nu sub 2 bands of ammonia, collision-broadened by hydrogen. The measurements were made at room temperature with a spectral resolution of 0.15 per cm. Line intensities and self-broadened half-widths were also measured. From the line-intensity data, an estimate of S sub band = 600 plus or minus 30 per sq cm per atm has been derived for the absolute intensity of the pair of bands. Hydrogen-broadened half-widths of all the lines have been found to be equal to 0.075 plus or minus 0.004 per cm per atm. For all the lines measured, shapes of the lines in NH3-H2 collisions seem to conform to the super-Lorenz line shape proposed by Varanasi et al. (1972) for dipole quadrupole collisions.
The electromagnetic rocket gun -- A novel launch concept

A novel propulsion concept is proposed which has the potential to accelerate large masses to high velocities. The novel concept is an electromagnetic gun where the projectile is a rocket. As in a rocket, where the propellant cools and thereby prevents the rocket to burn up, the same happens in the proposed concept where the propellant also cools the projectile and prevents its vaporization. The propellant is resistively heated by the magnetic field to high temperatures and ejected from the projectile with high velocity. The total thrust is the sum of the magnetic and recoil force. The energy to drive the jet is externally supplied making the specific impulse much larger than for chemical rockets.
Sarcoidosis-associated MHC Ags and the development of cutaneous and nodal granulomas following allogeneic hematopoietic cell transplant

Sarcoidosis-associated MHC Ags and the development of cutaneous and nodal granulomas following allogeneic hematopoietic cell transplant
Nicotinic cholinergic receptors associated with mammalian cerebral vessels

Current evidence suggests that the cerebral vasculature may be modulated by cholinergic nerves. We used ligand binding methods to examine the presence of nicotinic cholinergic receptors in brain vasculature. We found carbachol-displaceable [3H]acetylcholine (ACh) and [3H]nicotine (NIC) binding sites in preparations of intraparenchymal cerebral microvessels (CMV) and larger pial vessels from human and pig brains. Specific binding sites for [3H]ACh and [3H]NIC in cerebral microvessels were saturable and comparable in density to those in cerebral cortex. The Kds for the two ligands ranged 3-18 nM whereas the Bmaxs were 25-45 fmol/mg protein. In contrast, the binding of [3H]pirenzipine or [3H]quinuclidinyl benzilate, index for muscarinic receptors, was low (9-15% of cortex) in microvessels compared to the cerebral cortex. Our observations suggest the association of cholinergic nicotinic receptors with cerebral microvessels, which may be involved in the modulation of the cerebral circulation by cholinergic neurons.
Transport through composite membranes, part 2: Impacts of roughness on permeability and fouling

Abstract Transport through composite membranes is influenced by the permeability and selectivity of the coating film and also by the skin layer pore morphology of the underlying porous support; however, the previous published research considered coating films with uniform thickness. Herein, we employed a numerical model to probe the impacts of coating film morphology on: (1) coating film permeability, (2) composite permeability, and (3) local permeate flux distribution. For the geometries modeled, coating film roughness can result in higher permeability provided that the mass of coating film is redistributed to produce both thinner and thicker cross-sections. On the other hand, permeability decreases when rough features are placed over a constant base film thickness. Further, rough coating films can exacerbate or dampen permeate flux ‘hot spots’ that appear over support membrane pores, depending on their relative orientation; however, dampening morphologies exhibit lower overall permeability even when the support membrane ‘solid phase’ is highly water-permeable. The presented theoretical results offer further insights into the fundamental challenges in designing high flux, fouling resistant RO membranes.
Manganese and methane in hydrothermal plumes along the East Pacific Rise, 8°40′ to 11°50′N

Abstract In November, 1991, we surveyed the water column for hydrothermal plumes along 350 km of the East Pacific Rise axis from 8°40′ to 11°50′N, using a combination of physical and chemical measurements. Our survey included the two major ridge segments north and south of the Clipperton Transform Fault at about 10°10′N, both limbs of the overlapping spreading centers (OSC's) at 9°03′N and 11°45′N, and a 30-km section of the next ridge segment to the south. We found vigorous plumes along most of this ridge axis, in keeping with its magmatically robust cross-section, axial summit caldera, and shallow, magma-related seismic reflector. These plumes were detectable by both physical (temperature and light attenuation) and chemical (dissolved Mn and CH4) measurements, although the chemical measurements were more sensitive. The least active sections were the southern third of the northern segment from 10°20 to 52′N and the OSCs, especially the OSC at 11°45′N. Plumes there had weak Mn and CH4 signals and were barely detectable by physical methods. These axial sections were the only ones surveyed that lie deeper than 2600 m and appear to be magma starved. The most active sections on the northern segment gave stronger signals for Mn and temperature than for CH4 and light attenuation, whereas the opposite was true on the southern segment, which was the site of a volcanic eruption at 9°45–52′N only seven months prior to our cruise. On the northern segment the four physical and chemical plume tracers correlated positively and linearly with one another, suggesting that the segment was fed by relatively uniform end-member fluids with a mean CH 4 Mn molar ratio of 0.075. The southernmost section surveyed, from 8°42′ to 9°08′N, closely resembled the northern segment. The rest of the southern segment fell into three sections with different CH 4 Mn ratios: 9°39 to 53′N with CH 4 Mn as high as 10, 9°08 to 39′N with CH 4 Mn of 0.51, and 9°53′ to 10°07′N with CH 4 Mn of 0.85. The section with the highest CH 4 Mn was the site of the volcanic eruption, which produced high-temperature, low-salinity, gas-rich vent fluids carrying abundant bacterial particles. The high CH4 concentrations are clearly associated with the volcanic eruption, but the origin of the CH4 is unclear.
Ground state representation of the infinite one-dimensional Heisenberg ferromagnet. IV. A completely integrable quantum system

Abstract The purpose of this article is to show that the ground state representation of the infinite one-dimensional spin 1 2 Heisenberg chain, with isotropic nearest neighbor interactions, provides an example of a completely integrable quantum system.
Online maintenance of very large random samples

Random sampling is one of the most fundamental data management tools available. However, most current research involving sampling considers the problem of how to use a sample, and not how to compute one. The implicit assumption is that a "sample" is a small data structure that is easily maintained as new data are encountered, even though simple statistical arguments demonstrate that very large samples of gigabytes or terabytes in size can be necessary to provide high accuracy. No existing work tackles the problem of maintaining very large, disk-based samples from a data management perspective, and no techniques now exist for maintaining very large samples in an online manner from streaming data. In this paper, we present online algorithms for maintaining on-disk samples that are gigabytes or terabytes in size. The algorithms are designed for streaming data, or for any environment where a large sample must be maintained online in a single pass through a data set. The algorithms meet the strict requirement that the sample always be a true, statistically random sample (without replacement) of all of the data processed thus far. Our algorithms are also suitable for biased or unequal probability sampling.
Renal transplantation in older people.

Abstract Renal transplantation in people 60 years old or more is controversial due to the morbidity associated with immunosuppression and the scarcity of renal allografts. We have reviewed the outcome of 1222 consecutive renal transplants done at a single institution with a uniform immunosuppressive protocol over 10 years. 5-year graft survival was the same in the under sixties as in the sixties and over. Patient survival was worse in the older group (p=0 0001), but there were significantly fewer immunological graft losses: 11% vs 31% (p=0·0009; relative risk [RR]=0·36 [95% confidence interval 0·19-0·66]). A majority of the deaths in both groups were secondary to cardiovascular disease, not due to complications of immunosuppression. We conclude that renal transplantation in people 60 and over has results equivalent to a younger population. Age 60 and over should not be a major factor in considering if a patient is eligible for renal transplantation.
Opportunities for improving global cardiovascular quality of care and outcomes.

An estimated 17 million people worldwide die of cardiovascular disease, particularly acute myocardial infarction and stroke, each year.[1][1] Fortunately, a number of therapies have been demonstrated to substantially reduce morbidity and mortality in patients presenting with acute myocardial
Trends in Soy IgE Levels in Food Allergic Patients

U E S D A Y 806 Trends in Soy IgE Levels in Food Allergic Patients Edith Schussler, MD, Manish Ramesh, MD, PhD, Jacob D. Kattan, MD, Julie Wang, MD, FAAAAI; Icahn School of Medicine at Mount Sinai, New York, NY, Montefiore Medical Center, New York, NY. RATIONALE: Soy allergy is one of the most common food allergies, affecting approximately 0.4% of children. We examined trends in soy serum IgE (sIgE) levels over time. METHODS: This was a retrospective chart review of all patients at our teaching institution who had soy sIgE drawn on 2 or more occasions and had a diagnosis code of 693.1 (food allergy), or 995 (anaphylaxis), between January 1, 2003, and January 1, 2013. RESULTS: 315 patients had 2 or more soy sIgE levels performed (median sIgE 7.46 kUA/L, median age 5.9 years). Those with starting values of >/55 kUA/L showed greater variability in their levels on subsequent visits (median change -1.04, mean -0.17, range -63.9 to 77.1), than those with starting values of /55kUA/L show greater variability in levels on subsequent visits than those with levels <5 kUA/L. When initial soy sIgEwas performed under age 3, subsequent levels tended to increase. When levels were performed above age 3, levels tended to decrease on subsequent visits.
Bringing the ‘Dismal Science’ to Life: Teaching Economics Through Multimedia

Abstract This article examines the pedagogical benefits of using multimedia in the teaching of economics at undergraduate level. It also provides an example from my own teaching to serve as a reference for lecturers interested in creating an interactive learning environment, which prompts genuine two-way discussion in the classroom and produces better learning outcomes for students. The final section ties in the use of multimedia with broader debates among economists about the appropriate level of government intervention in the economy. The paper concludes by arguing that the use of multimedia has strong pedagogical advantages in stimulating greater student engagement and helping to rectify the image of economics in the wider community. Lecturers interested in using multimedia in their teaching will find an extensive list of web resources at the end of this paper.
The relationship between life event measures and anxiety and its cognitive correlates

Abstract The following paper reports an investigation of the relationship between various life event measures and some important measures of anxiety and its cognitive correlates. The results suggest that (i) measures of both trait anxiety and worrying are significantly related to measures of daily hassles, but are unrelated to other life event measures such as negative life events or world events, and (ii) both the tendency to interpret events as threatening and the tendency to seek out threat-relevant information (‘monitoring’) were significantly related to measures of daily hassles but unrelated to other life event measures. These results suggest that the relationship between daily hassles and trait anxiety extends to some of the important cognitive phenomena associated with anxiety, and they provide a means of conceptualizing the relationship between daily hassles and trait anxiety as an interactive one.
Reactions of seven coordinate complexes. Synthesis, structure, and copper complex of the novel ligand 3-methyltriazolo(1,5-a)6-acetylsemicarbazonepyridine

Abstract The reaction of aquachloro(2,6-diacetylpyridinedisemicarbazone)copper(II) with hydrazine hydrate gave the copper complex of 3-methyltriazolo(1,5-a)6-acetylsemicarbazonepyridine. The free ligand was isolated from the copper complex. The X-ray structures of both the copper complex and the free ligand are reported. The copper complex and the free ligand both crystallize in the triclinic space group P 1 with 2 molecules per cell. The Cu complex has cell dimensions of a=8.8574(4), b=10.1764(5), c=10.4434(5) A, α=71.956(1), β=64.913(1), and γ=81.597(1)°. The Cu ion is in a square pyramidal arrangement, with the Cu, the ligand, and a Cl in the plane and a disordered Cl and H2O in the apical position. The ligand has cell dimensions of a=7.2696(7), b=8.0516(7), c=9.9326(9) A, α=110.534(2), β=96.730(2), and γ=100.089(2)°. The ligand is planar with a conformation determined by an internal N–H⋯H hydrogen bond. The role of the Cu ion in the formation of the triazolopyridine is discussed.
Alignment of the B" subunit of RNA polymerase III transcription factor IIIB in its promoter complex.

Abstract TFIIIB, the central transcription initiation factor of the eukaryotic nuclear RNA polymerase (pol) III is composed of three subunits: the TATA-binding protein; Brf, the TFIIB-related subunit; and B", the Saccharomyces cerevisiae,TFC5 gene product. The orientation of the B" subunit within the TFIIIB-DNA complex has been analyzed at two promoters by two approaches that involve site-specific photochemical protein-DNA cross-linking: a collection of B" internal and external deletion proteins has been surveyed for those deletions that alter the interaction of B" with DNA or change the orientation of B" relative to DNA; a method for regionally mapping cross-links between specific DNA sites and 32P-end-labeled protein has also been applied. The results map an N-proximal segment of B" to the upstream end of the TFIIIB-DNA complex and amino acids 299–315 to the principal DNA-contact site, approximately 8 base pairs upstream of the TATA box. The analysis also indicates that a segment comprising amino acids 316–434 loops away from DNA, and locates the C-proximal 170 amino acids of B" downstream of the TATA box. Examination of two-cross-link products formed by DNA with adjacent and nearby photoactive nucleotides supports the conclusion that Brf and B" share an extended interface along the length of the TFIIIB-DNA complex.
Drift wave excitation in a collisional dusty magnetoplasma with multi-ion species

We investigate the drift dissipative instability in a non-uniform magnetized plasma composed of electrons, positive ions, negative ions and negatively charged dust particles. We use a multi-fluid plasma model and derive a dispersion relation for the electrostatic drift waves with frequencies much smaller than the ion gyrofrequencies and wavelengths longer than the ion gyroradii. The presence of the negatively charged, massive dust grains affects the drift wave frequency and the growth rate of the drift dissipative instability. The present results may be relevant to space and laboratory magnetoplasmas containing negative ions and charged dust grains.
A new rectenna circuit using a bow-tie antenna for the conversion of microwave power to dc power

The novel rectenna circuit presented, which integrated a bowtie antenna with a diode, is capable of broadband, high-efficiency operation, and is insensitive to incident field angle. The device is noted, moreover, to behave as a lowpass filter for dc output. For 2.45 GHz operation, a 79-percent conversion efficiency has been demonstrated.
Object-oriented object recognition system

Pattern recognition systems have been developed using a variety of technologies from many disciplines. With the development of new technologies in these disciplines comes the possibility for improving pre-existing recognition systems. Such is the case of using object-oriented programming concepts from computer science in object recognition applications. Efficient object recognition imposes new requirements to the library (database) of objects. The library has to go beyond the role of a simple storage medium and provide efficient retrieval and management capabilities for the objects' information. An entity can be stored in an object structure along with its descriptive attributes or features. In identifying an unknown object, the object recognition system queries the database by the passage of messages checking the similarities of the unknown object to each of the objects in the database on a feature basis. The only interface the database shares with the object recognition system is through the passing of messages which allows for flexibility in how the database processes the messages. This is only one of many advantages of the use of an object-oriented database in an object recognition system. An object recognition system utilizing object-oriented concepts is developed in detail.
Drug reaction with eosinophilia and systemic symptoms (DRESS) associated with azithromycin in acute Epstein-Barr virus infection.

: We report the first pediatric case of drug reaction with eosinophilia and systemic symptoms associated with azithromycin use in the setting of acute Epstein-Barr virus infection in an 8-year-old boy. Our patient presented with fever, cutaneous eruption, eosinophilia, and hypotension requiring intensive care unit admission. He was discharged in good condition without any long-term sequelae. This case underscores the importance of timely and accurate diagnosis of acute viral infections and appropriate use of antibiotics as well as recognition of the clinical signs of drug reaction with eosinophilia and systemic symptoms.