cssi/SciSciGPT-SciSciNet huggingface dataset:
CCN6 Knockdown Disrupts Acinar Organization of Breast Cells in Three-dimensional Cultures through Up-regulation of Type III TGF-β Receptor

While normal cells in the human breast are organized into acinar structures, disruption of the acinar architecture is a hallmark of cancer. In a three-dimensional model of morphogenesis, we show that down-regulation of the matrix-associated tumor suppressor protein CCN6 (WNT1-inducible-signaling pathway protein 3) disrupts breast epithelial cell polarity and organization into acini through up-regulation of the type III transforming growth factor-β receptor (TβRIII or betaglycan). Down-regulation of CCN6 in benign breast cells led to loss of tissue polarity and resulted in cellular disorganization with loss of α6 integrin-rich basement membrane and the basolateral polarity protein E-cadherin. Silencing of TβRIII with shRNA and siRNA rescued the ability of breast epithelial cells to form polarized acinar structures with reduced matrix invasion and restored the correct expression of α6 integrin and E-cadherin. Conversely, CCN6 overexpression in aggressive breast cancer cells reduced TβRIII in vitro and in a xenograft model of CCN6 overexpression. The relevance of our studies to human breast cancer is highlighted by the finding that CCN6 protein levels are inversely associated with TβRIII protein in 64%of invasive breast carcinomas. These results reveal a novel function of the matricellular protein CCN6 and establish a mechanistic link between CCN6 and TβRIII in maintaining acinar organization in the breast.
Carbon Nanotubes in Regenerative Medicine

This chapter focuses on the latest developments in applications of carbonnanotubes (CNTs) for regenerative medicine. Regenerative Medicine focuses on technologies to create functional tissues to repair or replace tissues or organs lost due to trauma or disease. Carbon nonotubes (CNTs) have been under investigation in the past decade for an array of applications due to their unique and versatile properties. In the field of regenerative medicine, they have shown great promise to improve the properties of tissue engineering scaffolds. Drug delivery and imaging of engineering tissues. The chapter will review these latest advances
Stem cell transplantation in the fetus.

BackgroundIn utero transplantation (IUT) of hematopoietic stem cells has the potential to treat a large number of hematologic and metabolic diseases amenable to partial replacement of the hematopoi...
Common plant ingestions.

Of the enormous number of calls regarding toxic and nontoxic plant ingestions received by the Florida Poison Information and Toxicology Resource Center each year, the majority are about accidental ingestions in the pediatric population. These tend to involve household plants ranging from nontoxic to those with life-threatening cardiotoxicity. Several recent cases of ingestions with the intent of producing hallucinogenic effects have been presented to the Poison Center. Other misadventures have resulted from the similar appearance of toxic and nontoxic plants. The three poison centers in Florida have access to toxicologic consultation to help the clinician assess the severity of a plant poisoning and to guide in treatment decisions. Language: en
Correlating structure and fluorescence dynamics of quantum dot clusters using super-resolution imaging

Clusters of quantum dots exhibit fluorescent behavior that differs from that of individual particles. Bulk measurements involving a large number of particles obscure these dynamics. Synthesizing clusters with 5–10 particles enables the study of collective behavior where single-molecule fluorescence techniques can be applied. Super-resolution microscopy of these clusters correlated with SEM imaging reveals the influence of geometry and structure on emission dynamics. Signatures of energy transfer can be seen in the form of enhanced blinking. Motion of the emission center of the cluster is tracked, made possible by the independent blinking events of the individual particles. Discrete steps in the localization are observed as random switching between various on/off configurations moves the location of the emission center.
Synthesis, structural, spectroscopic, and magnetic characterization of two-coordinate cobalt(II) aryloxides with bent or linear coordination.

Treatment of the cobalt(II) amide, [Co{N(SiMe3)2}2]2, with four equivalents of the sterically crowded terphenyl phenols, HOArMe6 (ArMe6 = C6H3-2,6(C6H2-2,4,6-Me3)2) or HOAriPr4 (AriPr4 = C6H3-2,6(C6H3-2,6-Pri2)2), produced the first well-characterized, monomeric two-coordinate cobalt(II) bisaryloxides, Co(OArMe6)2 (1) and Co(OAriPr4)2 (2a and 2b), as red solids in good yields with elimination of HN(SiMe3)2. The compounds were characterized by electronic spectroscopy, X-ray crystallography, and direct current magnetization measurements. The O–Co–O interligand angles in 2a and 2b are 180°, whereas the O–Co–O angle in 1 is bent at 130.12(8)° and its cobalt(II) ion has a highly distorted pseudotetrahedral geometry with close interactions to the ipso-carbons of the two flanking aryl rings. The Co–O distances in 1, 2a, and 2b are 1.858(2), 1.841(1), and 1.836(2) A respectively. Structural refinement revealed that 1, 2a, and 2b have different fractional occupations of the cobalt site in their crystal structures:...
Photoelectrical Counting of Outgoing and Incoming Honey Bees

A photoelectric counter was developed for single-frame observation beehives. Glass tubes protruding in opposite directions from the center partition separated the outgoing from the incoming honey bees, Apis mellifera L. Each bee that passed through the counter in each direction was recorded on a digital counter. A single time lapse camera periodically recorded the data from both counters.
Mediation and Progress in Mary Shelley’s History of a Six Weeks’ Tour

The article analyses Mary Shelley’s philosophy of history in History of a Six Weeks’ Tour. The terms of Shelley’s sceptical examination of progressive notions of history correspond to her sense of the powers and limitations of writing as a medium. In this her first published work, Shelley creates a set of motifs from tropes of the medium of writing and of its influence in history that reappear in the historiography of her later fictions, including the implication of loss in the process of progress, the reopening of missed opportunities, and the merely spectral afterlife that writing can grant.
Tactical urbanism: short-term action for long-term change

At a time when urban design has come back to the fore and big projects are remaking North American cities, the most exciting developments might be happening at the margins of the field. While desig...
A low-power SHA-3 designs using embedded digital signal processing slice on FPGA

Two low-power SHA-3 designs are provided on UltraScale FPGA using its embedded Digital Signal Processing (DSP) slice; one for the area constrained environments and the other for high-speed applications.All bitwise logical operations of SHA-3 are logically grouped in 48-bit wide parallel operations to get maximum benefit of Xilinx DSP48E2 slice structure.Logical Cascade Structure (LCS) strategy is used to confine maximum SHA-3 logic within same DSP slice column and also to get maximum benefit from its low-power dedicated interconnect.The DSP based compact SHA-3 design utilizes 79.10% less DSP slices and consumes only 1/7th of power while high-speed 1600-bit design provides 23.57 Gbps with consumption of only 1/5th of power. Display Omitted This work presents two low-power Secure Hash Algorithm-3 (SHA-3) designs on Field Programmable Gate Array (FPGA) using embedded Digital Signal Processing (DSP48E) slice, one for area constrained environments and the other for high-speed applications. The seven equations of SHA-3 are logically optimized to three and four stage pipelined organizations for our compact and high-speed designs, respectively. The maximum parallelism between all the bitwise operations of different stages of SHA-3 is explored with respect to the 48-bit structure of DSP slice. Further Logical Cascade Structure (LCS) design strategy is proposed in accordance with the DSP slice organization. These optimizations result in saving of resources and at the same time achieve low-power with high performance. Our compact design results in saving of 79.10% DSP slices and consumes only 1/7th of power while 1600-bit DSP design provides 23.57 Gbps throughput and consumes only 1/5th of power as compared to the conventional SHA-3 designs.
Enhanced superconducting properties of YBa2Cu3O7−δ thin film with magnetic nanolayer additions

Abstract Vertically aligned nanocomposite (VAN) ( La 0.7 Sr 0.3 MnO 3 ) 0.5 (CeO 2 ) 0.5 and pure La 0.7 Sr 0.3 MnO 3 layers were incorporated into YBa 2 Cu 3 O 7−δ (YBCO) thin films as bilayer stacks for magnetic flux pinning enhancement. The films show high epitaxial quality, suggested by XRD and TEM study. The critical temperature T c of the bilayers is about 90 K, which is close to that of pure YBCO films, while both the self-field J c sf and in-field critical current density J c in-field are largely enhanced. Among all samples, the film with VAN cap layer shows the highest J c values in all field ranges. This study demonstrates an effective way towards the tunable pinning effect for YBCO coated conductors by both defect and magnetic pinning.
The Effect of Oil Foot Medium on the Growth and Economic Benefit of Shimeji

In this paper,inexpensive oil feet added to the culture medium to study their growth and fruiting body of the impact of product benefits,the result obtained the expected ideal test results.This study made full use of industrial oil feet to replace the traditional cultural materials for shimeji production,waste utilization can reduce the pollution of the environment,but also greatly reduce the cost of production of Shimeji,access to higher economic efficiency.
Design and analysis of fault-tolerant pipelined multicomputer networks

Parallel architectures rely on fast inter-processor communication to exploit concurrency in computational tasks. Low message latency and high network throughput are necessary to exploit parallelism at increasingly smaller granularities. However, as networks get larger, the probability of component failures increase as well. We would like such a system to continue to operate correctly in the presence of such failures. In addition, we desire a graceful degradation of performance as the number of failures increases. The objective of this dissertation is to develop a framework for the design and analysis of fault-tolerant pipelined interconnection networks. Solutions to the problems of both static and dynamic link faults are presented. Flexible variants--pipelined circuit-switching (PCS) and acknowledged pipelined circuit-switching (APCS)--of the common wormhole routing communication mechanism are proposed for fault-tolerant communication support. In addition, an adaptive routing algorithm that utilizes misrouting and backtracking (MB-m) is presented and shown to provide good fault-tolerant properties. A dynamic fault recovery mechanism is also presented that gives deadlock-free network operation even in the presence of dynamic link failures. An analytical model of network performance is developed and used to provide insight into various facets of router design. Finally, a hardware implementation of PCS and MB-m is presented to demonstrate the viability of these concepts.
Visual Cortex of Turtles

Turtles have a visual cortex that receives direct projections from the dorsal lateral geniculate complex of the dorsal thalamus. This article reviews the current knowledge of the organization of turtle visual cortex and comments briefly on its evolution.
Tourism and financial development in small states: Evidence from Caribbean countries

Tourism expenditure in Caribbean countries represents the single largest inflow of foreign exchange and is associated with a significant amount of international capital flows. Yet, the relationship...
Deployable Propulsion, Power and Communication Systems for Solar System Exploration

NASA is developing thin-film based, deployable propulsion, power, and communication systems for small spacecraft that could provide a revolutionary new capability allowing small spacecraft exploration of the solar system. By leveraging recent advancements in thin films, photovoltaics, and miniaturized electronics, new mission-level capabilities will be enabled aboard lower-cost small spacecraft instead of their more expensive, traditional counterparts, enabling a new generation of frequent, inexpensive deep space missions. Specifically, thin-film technologies are allowing the development and use of solar sails for propulsion, small, lightweight photovoltaics for power, and omnidirectional antennas for communication. Like their name implies, solar sails 'sail' by reflecting sunlight from a large, lightweight reflective material that resembles the sails of 17th and 18th century ships and modern sloops. Instead of wind, the sail and the ship derive their thrust by reflecting solar photons. Solar sail technology has been discussed in the literature for quite some time, but it is only since 2010 that sails have been proven to work in space. Thin-film photovoltaics are revolutionizing the terrestrial power generation market and have been found to be suitable for medium-term use in the space environment. When mounted on the thin-film substrate, these photovoltaics can be packaged into very small volumes and used to generate significant power for small spacecraft. Finally, embedded antennas are being developed that can be adhered to thin-film substrates to provide lightweight, omnidirectional UHF and X-band coverage, increasing bandwidth or effective communication ranges for small spacecraft. Taken together, they may enable a host of new deep space destinations to be reached by a generation of spacecraft smaller and more capable than ever before.
Properties of H 3 Λ

The properties of the hypernucleus $_{\ensuremath{\Lambda}}\mathrm{H}^{3}$ were measured in an analysis of helium-bubble-chamber pictures taken at the Argonne ZGS. Some 90 examples of the production reaction ${K}^{\ensuremath{-}}+{\mathrm{He}}^{4}\ensuremath{\rightarrow}_{\ensuremath{\Lambda}}\mathrm{H}^{3}+p+{\ensuremath{\pi}}^{\ensuremath{-}}$ were found in which the ${K}^{\ensuremath{-}}$ stopped and the $_{\ensuremath{\Lambda}}\mathrm{H}^{3}$ decayed via ${\ensuremath{\pi}}^{\ensuremath{-}}$ emission. Twenty-seven events were observed to decay via the two-body mode $_{\ensuremath{\Lambda}}\mathrm{H}^{3}\ensuremath{\rightarrow}{\ensuremath{\pi}}^{\ensuremath{-}}{\mathrm{He}}^{3}$, with the remaining events decaying to ${\ensuremath{\pi}}^{\ensuremath{-}}\mathrm{pd}$ or ${\ensuremath{\pi}}^{\ensuremath{-}}\mathrm{ppn}$. The production rate was measured to be (${1.8}_{\ensuremath{-}0.6}^{+0.7}$)\ifmmode\times\else\texttimes\fi{}${10}^{\ensuremath{-}3}$ per stopping ${K}^{\ensuremath{-}}$. The mean life of the hyper-fragment was measured from the two-body decay mode as (${2.64}_{\ensuremath{-}0.52}^{+0.84}$)\ifmmode\times\else\texttimes\fi{}${10}^{\ensuremath{-}10}$ sec. The lifetime obtained from the three-body decays was consistent with this value, after the elimination of a serious source of background. The binding energy of $_{\ensuremath{\Lambda}}\mathrm{H}^{3}$ was measured to be 0.25\ifmmode\pm\else\textpm\fi{}0.31 MeV. The decay ratio ${R}_{3}=\frac{\ensuremath{\Gamma}(_{\ensuremath{\Lambda}}\mathrm{H}^{3}\ensuremath{\rightarrow}{\ensuremath{\pi}}^{\ensuremath{-}}{\mathrm{He}}^{3})}{\ensuremath{\Gamma}(_{\ensuremath{\Lambda}}\mathrm{H}^{3}\ensuremath{\rightarrow}\mathrm{all} {\ensuremath{\pi}}^{\ensuremath{-}})}$ was measured to be ${0.36}_{\ensuremath{-}0.06}^{+0.08}$, in agreement with values from previous experiments and with the value calculated for spin \textonehalf{} for the $_{\ensuremath{\Lambda}}\mathrm{H}^{3}$ hypernucleus.
Genomic analysis of untreated prostate adenocarcinoma, treatment-emergent neuroendocrine carcinoma, and circulating tumor cells.

200Background: The prostate cancer genome evolves in response to therapeutic pressure, requiring repeated evaluation as the disease progresses. Biopsies of metastatic sites are invasive and often l...
Incidence of neurotoxicity and ototoxicity with cisplatin vs. non-cisplatin regimens: A meta-analysis with subgroup analyses based on renal eligibility criteria.

e15555 Background: Using glomerular filtration rate (GFR) to screen patients for trial eligibility may reduce the risk of cisplatin (CIS) associated nephrotoxicity compared to serum creatinine (SCr...
Special Education Services for Girls with Serious Emotional Disturbance: A Case of Gender Bias?.

Despite the fact that boys greatly outnumber girls in receiving services under the category Serious Emotional Disturbance (SED), the possibility of bias against girls with SED has received relative...
Cutaneous infections from viral sources in solid organ transplant recipients.

Abstract Although there is an abundance of information on cutaneous malignancies in transplant recipients, information on cutaneous infections in solid organ transplant recipients is underrepresented in dermatologic and transplant literature. Our paper provides a comprehensive review of viral cutaneous infections within the solid organ transplant population. We compiled literature specific to the solid organ transplant population, reviewing cutaneous manifestations secondary to viral infections. Furthermore, we discuss the diagnosis and treatment of such infections. The following is a list of the viruses that we will discuss: - Human papillomavirus - Human herpesvirus type 1,2 - Varicella-Zoster virus - Cytomegalovirus - Epstein-Barr virus - Human herpesvirus type 6 variant A - Human herpesvirus type 6 variant B - Human herpesvirus type 7 - Human herpesvirus 8 - Trichodysplasia spinulosa polyomavirus - Human polyomavirus 7 - Merkel cell polyomavirus - Molluscum contagiosum
De novo digenic mutations of telomere-associated proteins and inflammasomes initiate many chronic human diseases: a hypothesis

Many age-related human diseases have inflammatory components of uncertain causes. It has been proposed that some may be initiated or sustained by doubly mutated immune cells that have both inappropriately activated inflammasomes and enhanced replicative potential. Genes of cells that express mutant TERT and NLRP3 proteins are presumed to be at increased risk for mutagenesis because they reside in subtelomeric regions of chromatin that are deficient in DNA repair mechanisms. Expanded clones of proinflammatory cells can occur throughout one's lifetime and could represent an alternative explanation for some forms of pathologic scarring that are now attributed to truncated telomeres.-Marchesi, V. T. De novo digenic mutations of telomere-associated proteins and inflammasomes initiate many chronic human diseases: a hypothesis.
Qualitative Analysis of Open-ended Comments in Introductory CS Courses: (Abstract Only)

End-of-course evaluations and other student surveys typically include the opportunity for students to provide free-form comments. These are rich sources of data but are often only subjectively taken into account to further improve course delivery or analyze the effectiveness of assignments. We designed several puzzle-based assignments for typical CS1/2 topics and surveyed students as part of our efforts to analyze the assignments' efficacy and improve them over time. The surveys included traditional measures such as demographic data, Likert-scaled questions about assignment perceptions, and open-ended comments. With thousands of survey responses, we wanted to see if the open-ended comments yield additional, statistically significant, insights on either the assignments or students' learning. We developed a coding scheme for the comments using grounded theory analysis to represent patterns among the data. After refining the coding scheme we statistically analyzed the comments and found some interesting relationships, not apparent from the Likert-scaled questions, among certain codes. We also conducted extensive semi-structured interviews with instructors and student teaching assistants, also using grounded theory analysis to develop a set of codes for these different perspectives. The coding processes themselves allowed for a deeper understanding of the concerns about and appreciation for the assignments from both groups of participants. This poster reports on how the statistical results and the coding schemes, including the overlap and dissonance between the two coding schemes, inform our continued efforts to improve both assignment development and future research on the teaching and learning of CS concepts.
On the Asymptotic Properties of the Solutions of Some Functional Equations

We establish new properties of the solutions of functional equations with constant delay and linearly transformed argument.
The Representations and Tensor Operators of the Unitary Groups U(n)

Publisher Summary This chapter reviews the representation theory of the unitary groups, U(n), deriving a system of basis vectors—the Gel'fand basis—and the matrix elements for the infinitesimal operators that span the Lie algebras of these groups. The chapter discusses the theory of tensor operators defined on the unitary groups (2a-f). The unitary groups, most particularly SU(3) and SU(6), have recently become objects of interest to physicists because of their usefulness in the study of elementary particle symmetries. The U(n) groups, as a family, have a further importance in that all of the classical groups can be embedded as subgroups; this property is much more useful for Lie groups than the corresponding embedding of all finite groups in the symmetric group, S(n). The chapter first gives an informal proof—due to Wigner and Stone—of the Peter-Weyl theorem, which has the corollary that all the irreducible unitary representations of a compact matrix group are generated by Kronecker products of a single faithful representation of the group, which, for convenience, is taken to be the defining representation, that is, the set of all n × n unitary matrices in the case of U(n),…. The problem of the reduction of the Kronecker products of the defining representation is then solved with the assistance of the representation theory of the finite symmetric groups.
Nitrogen metabolism of the isolated tissues of the rat

Little study has been devoted to the anabolic aspects of nitrogen metabolism in animals. The reason, of course, has been the difficulty of obtaining experimental conditions in which these can be observed, measured, and analyzed. The experiments of Krebs and Henseleit (1) on the formation of urea from ammonia with Warburg’s method of surviving slices of liver suggested that this method might be useful in a direct attack on a number of problems of nitrogen anabolism in animals; i.e., it might be possible to observe reactions in which there is a gain in free energy. It appears that for these reactions the intact cell structure is necessary.
Applications of Thin Film Amorphous Magnetic Materials

At about the same time that Duwez and coworkers first reported (1) methods for preparing amorphous alloys by rapid liquid quenching, methods were also discovered for preparing amorphous alloys by vapor quenching as shown by Mailer et al.. (2) A few years later, in the mid 1960’s both liquid (3) and vapor quenched amorphous alloys (4) were found to order magnetically. The applications of both classes of materials first received intense scrutiny in the early 1970’s with the discovery by Chaudhari et al. that vapor deposited, amorphous rare earth-transition metal alloys will support magnetic bubble domains (5). It was subsequently found that similar films with slightly different composition can be used as a medium for thermomagnetic storage with magneto-optical readout. (6) Also, in the early 70’s it was reported that liquid quenched ribbons of metal-metalloid amorphous magnetic alloys can be fabricated by high speed production methods (7) and that these materials have properties of, interest for low loss inductor core applications. (8)
Ground-State Dioxygen

The critical characteristic of ground state dioxygen is that it is a triplet instead of a singlet state. This fact contributes to the kinetic barrier in reactions with ground-state dioxygen and also influences the type of reactions that do occur.
Investigations of Granularity and Payoffs in 2×2 Games under Replicator Dynamics

This paper describes an investigation of several 2×2 games in iterated form. Players play the games repeatedly and are limited to mixed strategies, with particular actions chosen probabilistically. The games investigated include Prisoner’s Dilemma, Chicken, and Stag Hunt in various forms. The reward structure and the granularity of the games—number of games played per generation in the replicator dynamics—are the main factors investigated, with surprising results.
Lost-shell casting for rapid prototyping in RF and microwave applications

Lost-shell casting as a novel fabrication technique is examined, providing the durability of solid metal components with the shape flexibility of additive manufacturing. The feasibility of lost-shell casting is established for use in microwave and RF applications. A well known, standard rectangular cavity resonator design was used to validate this novel method of fabrication. Using lost-shell casting, a cavity resonator with a quality factor of 2200 was constructed. The results shown in this work confirm the validity of lost-shell casting as a novel method of rapid fabrication for completely metalised components in RF and microwave applications.
Hofstede's Cultural Dimensions of Values and Personal Value Orientation of Nigerian Managers: Implications for Management Practice

The paper investigates to what extent the personal value orientations of Nigerian managers, measured by using England's PVQ, fit the national cultural dimensions identified by Hofstede. While the study is not conclusive, the results suggest a fit. Implications for the transfer of management know-how to different cultures, especially LDCs were given.
Visualizing Compression of Deep Learning Models for Classification

Deep learning models have made great strides in tasks like classification and object detection. However, these models are often computationally intensive, require vast amounts of data in the domain, and typically contain millions or even billions of parameters. They are also relative black-boxes when it comes to being able to interpret and analyze their functionality on data or evaluating the suitability of the network for the data that is available. To address these issues, we investigate compression techniques available off-the-shelf that aid in reducing the dimensionality of the parameter space within a Convolutional Neural Network. In this way, compression will allow us to interpret and evaluate the network more efficiently as only important features will be propagated throughout the network.
Leveraging big data to advance knowledge in pediatric heart failure and heart transplantation

Despite many therapeutic advances for children with heart failure and those who undergo heart transplantation, robust evidence to guide clinical practice remains limited. The approach to these patients has been largely based upon available evidence in the adult population. Each pediatric heart center has a relatively small number of heart failure and heart transplant patients, making single-center studies largely underpowered.
Antitumor effect of insulin-like growth factor-1 receptor inhibition in head and neck squamous cell carcinoma.

Objectives The insulin-like growth factor-1 receptor (IGF1R) has been implicated in therapeutic resistance in head and neck squamous cell carcinoma (HNSCC), and small molecule tyrosine kinase inhibitors (TKIs) of IGF1R activity may have anticancer activity. Therefore, the relationship between survival and IGF1R expression was assessed for oral cavity (OC) cancer, and the antitumor effects of two IGF1R-TKIs, OSI-906 and BMS-754807, were evaluated in HNSCC cell lines in vitro. Methods Clinical outcome data and tissue microarray immunohistochemistry were used to generate IGF1R expression-specific survival curves. Immunoblot, alamarBlue proliferation assay, trypan blue exclusion viability test, clonogenic assay, flow cytometry, and reverse phase protein array (RPPA) were used to evaluate in vitro responses to IGF1R-TKIs. Results For patients with stage III/IV OCSCC, higher IGF1R expression was associated with poorer overall 5-year survival (P = 0.029). Both BMS-754807 and OSI-906 caused dose-dependent inhibition of IGF1R and Akt phosphorylation and inhibited proliferation; BMS-754807 was more potent than OSI-906. Both drugs reduced HNSCC cell viability; only OSI-906 was able to eliminate all viable cells at 10 μM. The two drugs similarly inhibited clonogenic cell survival. At 1 μM, only BMS-754807 caused a fourfold increase in the basal apoptotic rate. RPPA demonstrated broad effects of both drugs on canonical IGF1R signaling pathways and also inhibition of human epidermal growth factor receptor-3 (HER3), Src, paxillin, and ezrin phosphorylation. Conclusion OSI-906 and BMS-754807 inhibit IGF1R activity in HNSCC cell lines with reduction in prosurvival and proliferative signaling and with concomitant antiproliferative and proapoptotic effects. Such antagonists may have utility as adjuvants to existing therapies for HNSCC. Level of evidence NA Laryngoscope, 130:1470-1478, 2020.
A Simplified Digital Closed-loop Current Control of Three-phase PV Inverter Operating in Triangular Conduction Mode

An adoption of SiC device brings benefits on performances of three-phase photovoitaic (PV) inverters. As the switching loss of SiC devices is concentrated at a turn-on instant, triangular conduction mode (TCM) can be utilized to achieve zero-voltage switching (ZVS) for SiC-MOSFETs thus minimizing the switching energy. When the three-phases are coupled through a neutral point of the load, the dynamics of three-phases interact with each other. Such a coupling complicates conventional current-control methods based on a single-phase TCM inverter to be extended to the three-phase applications. In this paper, a simplified digital closed-loop control for three-phase TCM inverter has been presented. A new reference frame has been proposed based on the conduction-mode with a simple conduction-mode decision method. Issues for the current control on the proposed reference frame are identified, and an architecture for the current controller has been investigated. The proposed control architecture has been experimentally verified with three-phase three-level 40 kW PV inverter with a digital control board with TMS320F28343.
Rovibronic symmetry correlation in molecular combination and dissociation. II. The O2 + O2 ⇌ O4 (D2h) system

Abstract Rovibronic, vibronic and electronic correlation diagrams are constructed for the following reactions: X3Σg−(O2) · X3Σg−(O2) ⇌ {X1Ag(O4), a 3B2u(O4), b 5Ag(O4)}; X3·g−(O2) · a 1Σg+(O2 ⇌ {g 3B1g(O4), h 3B3u(O4)}; b 1Δg(O2) · b 1Δg(O2) ⇌ {A 1Ag(O4), B 1B1g(O4), C 1B3u(O4), D 1Ag(O4)}. The correlations are for an assumed rectangular D2h dimer conformation with the B2u vibration excited up to the ν = 3 state and with the rotations excited up to the j = 3 state. Approximate values of the vibronic energy levels, for both sides of the reactions, are presented. A peculiarity of the system due to the zero nuclear spin of the oxygen atom is pointed out. The possibility of level crossings due to orbit—rotation, spin—rotation and orbit—vibration interactions is discussed.
Performance on Video-Based Situational Judgment Test Items: Simulated Interracial Interactions

Individuals are known to categorize others into social groups based on cues like race and gender and to experience relative discomfort when interacting with “outgroup” members. Two experimental studies were used to examine whether actor demographic cues in situational judgment assessment items completed by test takers in a simulated employee selection context may lead to differences in their performance and reactions to the hiring organization. In both studies, test takers assumed the perspective of actors shown in video-based scenarios and indicated how they would respond to interaction partners (IPs) to whom they were racially similar or dissimilar. In Study 1, a given test taker responded to IPs of a constant gender; in Study 2, IPs’ gender varied across scenarios within each condition. In Study 1, Black test takers spent more time and scored better on two of the four scenarios when responding to racially similar IPs. These effects were not found in Study 2, but demographic cues showed new interactive effects on performance and reactions. We discuss the implications of different findings across the two studies.
Notch3 and DeltaB maintain Müller glia quiescence and act as negative regulators of regeneration in the light-damaged zebrafish retina.

Damage to the zebrafish retina stimulates resident Muller glia to reprogram, reenter the cell cycle, divide asymmetrically, and produce neuronal progenitor cells that amplify and differentiate into the lost neurons. The transition from quiescent to proliferative Muller glia involves both positive and negative regulators. We previously demonstrated that the Notch signaling pathway represses retinal regeneration by maintaining Muller glia quiescence in zebrafish. Here we examine which Notch receptor is necessary to maintain quiescence. Quantitative RT-PCR and RNA-Seq analyses reveal that notch3 is expressed in the undamaged retina and is downregulated in response to light damage. Additionally, Notch3 protein is expressed in quiescent Muller glia of the undamaged retina, is downregulated as Muller glia proliferate, and is reestablished in the Muller glia. Knockdown of Notch3 is sufficient to induce Muller glia proliferation in undamaged retinas and enhances proliferation during light damage. Alternatively, knockdown of Notch1a, Notch1b, or Notch2 decreases the number of proliferating cells during light damage, suggesting that Notch signaling is also required for proliferation during retinal regeneration. We also knockdown the zebrafish Delta and Delta-like proteins, ligands for the Notch receptors, and find that the deltaB morphant possesses an increased number of proliferating cells in the light-damaged retina. As with Notch3, knockdown of DeltaB is sufficient to induce Muller glia proliferation in the absence of light damage. Taken together, the negative regulation of Muller glia proliferation in zebrafish retinal regeneration is mediated by Notch3 and DeltaB.
COVID-19 in missiological and historical perspective

COVID-19 is affecting Christian mission in many different ways. Doubtless it is inspiring some people to initiate new mission efforts, while in other contexts it is causing thriving mission to chan...
Effect of Cleft Palate Repair Timing on Inpatient Complication Rate: Review of a National Database.

OBJECTIVES Timing of cleft palate repair is controversial. We aim to assess whether timing of cleft palate repair affects rates of inpatient complications, length of stay (LOS), and cost of stay. METHODS The Healthcare Cost and Utilization Project Kids' Inpatient Database 2009 was queried for all admissions with a primary diagnosis of cleft palate during which cleft palate repair was performed as a primary procedure. Age 6 months or less was termed "early" repair, while age >6 months was termed "standard" repair. Patients age >3 years old, inpatient stays >30 days, and those stays in which a cleft lip repair was performed were excluded. Logistic regressions were used to model the probability of complications. Generalized linear models and a natural log link function were used for LOS and hospital charges, using SAS 9.4. RESULTS We included 223 early and 1482 standard repair patients. Early repairs were exclusively performed in urban hospitals (P < 0.001). Eighty-nine patients experienced a total of 100 complications, including respiratory failure (N = 53), airway obstruction (N = 18), and oropharyngeal hemorrhage (N = 13). We found no significant difference in complication rate or total hospital charges in the 2 groups. The earlier repair group had a slightly longer LOS (P = 0.048). CONCLUSION Over 85% of United States cleft palate repairs are performed after 6 months of age. All early repairs were performed at urban hospitals, and had slightly longer LOS. There was a 5.1% overall complication rate. Available data revealed no significant difference in complication rates between early repair and standard repair groups. LEVEL OF EVIDENCE 3b.
Effects of jurors' identification with the victim depend on likelihood of victimization

Courtroom lore suggests that jurors identifying with rape victims will show antidefendant biases, but empirical findings do not unequivocally support this supposition. On theoretical bases, it was predicted that identification with the victim's gender would bias judgment against the defendant when the circumstances of the crime are likely to be encountered in the daily life of the juror or a related potential victim. Parents of female-only (PFs) or of male-only children (PMs) judged defendants in an alleged rape, occurring either in a library, where the victim had engaged in normal routine, or in a street, under unusual and risky conditions. PEs were more conviction-prone and punitive than PMs only for the library case. Findings support theories of defensive attribution (Shaver, 1970) and of attribution of actors and observers (Jones & Nisbett, 1972) but are inconsistent with a variant of defensive attribution (Walster, 1966) based on denial of chance occurrence of threatened harm. The systematic exclusion of jurors with certain characteristics from particular cases based on suppositional criteria is questioned, rigor of juror assessment notwithstanding. It is suggested that research concentrate on discovering the conditions under which biases are, or are not manifested, and on developing means of reducing bias effects in impaneled jurors.
Acculturation, Social Support and Suicidal Ideation among Asian immigrants in the United States

This study examined suicidal ideation among Asian immigrant adults in the United States, with consideration of the roles of acculturation and social support. Using the 2002-2003 National Latino and Asian American Study (NLAAS), I conducted latent class analysis with measures of U.S. cultural orientation and Asian ethnic affiliation to create a multidimensional construct of acculturation. Three acculturation groups were identified (assimilated, integrated, separated) that showed different associations with suicidal ideation. Then I analyzed how the association between acculturation status and suicidal ideation is moderated by social support, distinguishing between perceived versus received support. Findings revealed that the buffering role of social support is gender-specific, with perceived support from friends reducing the risk of suicidal ideation only among assimilated women. Implications for future research include further application of acculturation as a multidimensional construct to various health outcomes and behavior as well as to other immigrant subgroups. Public health intervention efforts aimed at preventing suicide should endeavor to promote perceptions of an available social support system among immigrants and aid in establishing sources of support outside the family particularly for immigrant women.
Generative Deep Learning for Virtuosic Classical Music: Generative Adversarial Networks as Renowned Composers.

Current AI-generated music lacks fundamental principles of good compositional techniques. By narrowing down implementation issues both programmatically and musically, we can create a better understanding of what parameters are necessary for a generated composition nearly indistinguishable from that of a master composer.
Mentorship, equity, and research productivity: lessons from a pandemic

The coronavirus pandemic is more fully exposing ubiquitous economic and social inequities that pervade conservation science. In this time of prolonged stress on members of the research community, primary investigators or project leaders (PLs) have a unique opportunity to adapt their programs to jointly create more equitable and productive research environments for their teams. Institutional guidance for PLs pursuing field and laboratory work centers on the physical safety of individuals while in the lab or field, but largely ignores the vast differences in how team members may be experiencing the pandemic. Strains on mental, physical, and emotional health; racial trauma; familial responsibilities; and compulsory productivity resources, such as high-speed internet, quiet work spaces, and support are unequally distributed across team members. The goal of this paper is to summarize the shifting dynamics of leadership and mentorship during the coronavirus pandemic and highlight opportunities for increasing equity in conservation research at the scale of the project team. Here, we (1) describe how the pandemic differentially manifests inequity on project teams, particularly for groups that have been structurally excluded from conservation science, (2) consider equitable career advancement during the coronavirus pandemic, and (3) offer suggestions for PLs to provide mentorship that prioritizes equity and wellbeing during and beyond the pandemic. We aim to support PLs who have power and flexibility in how they manage research, teaching, mentoring, consulting, outreach, and extension activities so that individual team members' needs are met with compassion and attention to equity.
Insurance Structure and Health Investment

The structure of health insurance does not compensate insurers for long-term investments in prevention, such as those against chronic disease. This paper explores the legal structure of chronic disease treatment by insurers, illustrates the failure of the associated incentives, and explores possible improvements and recommends that subsequent insurers (including Medicare) have an obligation to compensate the prior insurer for the averted expenses on diseases that were expected but did not occur.
The Association between Insurance Status and Acceptance of Chlamydia Screening By Teenagers Who Present for Preventive Care Visits

Abstract Study Objective The purpose of this study was to evaluate whether providers offer chlamydia screening to teenagers and/or whether screening is accepted at different rates depending on insurance type. Design Retrospective chart review. Setting Academic center serving urban and suburban patients between April 2009 and October 2011. Participants Nine hundred eighty-three health maintenance visits for asymptomatic, insured female adolescents aged 15-19 years. Interventions None. Main Outcome Measures Dichotomous dependent variables of interest indicated whether chlamydia screening was: (1) offered; and (2) accepted. The key independent variable insurance type was coded as ‘public' if Medicaid or Medicaid Managed Care and ‘private' if a commercial plan. χ 2 and logistic regression analyses were used to assess the significance of differences in screening rates according to insurance type. Results Of asymptomatic health-maintenance visits 933 (95%) had a documented sexual history and 339 (34%) had a documented history of sexual activity. After excluding those who had a documented chlamydia screen in the 12 months before the visit (n = 79; 23%), 260 visits met eligibility for chlamydia screening. Only 169 (65%) of eligible visits had chlamydia screening offered and there was no difference in offer of screening according to insurance type. Significantly more visits covered by public insurance had chlamydia screening accepted (98%) than those covered by private insurance (82%). Controlling for demographic factors, the odds of accepted chlamydia screening was 8 times higher in visits covered by public insurance than those with private insurance. Conclusion Although publically and privately insured teens were equally likely to be offered chlamydia screening, publically insured teens were significantly more likely to accept screening. Future research should investigate reasons for this difference in screening acceptance. These findings have implications for interventions to improve chlamydia screening because more adolescents are covered by parental insurance under the Affordable Care Act.
Photography's role in tourism; some unexplored relationships.

Abstract Chalfen, Richard M., “Photography's Role in Tourism: Some Unexplored Relationships,” Annals of Tourism Research ,” October/December 1979, VI(4):435–447. While photography is one of the most common attributes of tourist behavior, its role in tourism has never been studied. Tourist photography is understood as both photographs made by tourists and photographs made available to tourists by members of the host community. This paper draws attention to three unexamined topics: the relationship between certain tourist types and patterns of photographic behavior and/or content of photographs; the culturally variable standards of appropriate subject matter and camera use in different parts of the world; and the variety of responses exhibited by host communities to being photographed. Examples are given of host sensitivities and camera related disturbances. A trend is noticed in which host communities specify which images are appropriate and inappropriate for tourist photography.
Nighttime Driving and Visual Degradation

Recent developments which provide new insights into night driving accidents are reviewed. Selective Degradation: The mechanisms subserving steering are different from those underlying hazard recognition and these two modes of processing visual information are selectively impaired at night. Although it is possible to steer a vehicle as well at night as during the day, the ability to recognize and respond to infrequent hazards is seriously degraded. Night Myopia: Many individuals become nearsighted under reduced illumination. The finding that this is a normal consequence of the passive return of the accommodative system to an intermediate resting posdition has led to a procedure to ameliorate this effect. By determining the value of an individual's dark focus it is possible to provide a special night driving prescription which effectively eliminates night myopia.
Islamophobia/Islamophilia: Beyond the Politics of Enemy and Friend

Introduction/Islam as an Object of Fear and Affection: A Problem for Critical Analysis Andrew Shryock Part 1. Continuities and Transformations 1. Western Hostility toward Muslims: A History of the Present Tomaz Mastnak 2. The Khalil Gibran International Academy: Diasporic Confrontations in the Face of an Emerging Islamophobia Naamah Paley Part 2. Modern (Self) Criticism 3. The God That Failed: The Neo-Orientalism of Today's Muslim Commentators Moustafa Bayoumi 4. Gendering Islamophobia and Islamophilia: Lessons from the Example of Shi'i Muslim Women in Lebanon Lara Deeb 5. Bridging Traditions: Madrasas and Their Internal Critics Muhammad Qasim Zaman Part 3. Violence and Conversion in Europe 6. The Fantasy and Violence of Religious Imagination: Islamophobia and Anti-Semitism in France and North Africa Paul A. Silverstein 7. "I would never have become a Muslim if I had met Muslims before I met Islam": German Converts to Islam and Their Ambivalent Relations with Immigrant Muslims Esra Ozyurek Part 4. Attraction and Repulsion in Shared Space 8. Muslim Ethnic Comedy: Inversions of Islamophobia Mucahit Bilici 9. Competing for Muslims: New Strategies for Urban Renewal in Detroit Sally Howell Contributors Index