cssi/SciSciGPT-SciSciNet huggingface dataset:
Spectroscopic characterization of the copper(I)-thiolate cluster in the DNA-binding domain of yeast ACE1 transcription factor.

A polypeptide containing the amino-terminal region of ACEI (residues 1–122; 122*), the activator of yeast Cu-methallothionein gene transcription, shows charge-transfer and metal-centered UV absorption bands, and orange luminescence which are characteristic of Cu-cysteinyl thiolate cluster structures. These spectral features are abolished by the Cu(1) complexing agents CN* and diethyldithiocarbamate or exposure to acid, but not by the Cu(II)chelator. EDTA. Binding of the polypeptide to its specific DNA recognition site, but not to calf-thymus double-stranded DNA, induces quenching of its Tyr and Cu-S cluster luminescence emission. The CD spectrum is characteristic of a tightly folded structure that may be organized around the Cu cluster.
Genome size and nucleotypic variation in Malus germplasm.

The genus Malus has anywhere between 25 and 33 species along with several subspecies. Malus species as well as clones within the same species have varying ploidy levels, as these are more than like...
A study of the use of home reliners in dentures

Abstract A study of 29 subjects who had added or applied home reliner materials to their dentures has been presented. These subjects were seeking a means of comfort and masticatory improvement while unknowingly introducing hazards which resulted in irreversible deformation of the hard and soft tissues of the oral cavity. The responsibility of the dental profession to its patients demands that complete denture service include anticipation of the problems attendant to the insertion of dentures, to use every possible precaution and safeguard in the construction of complete dentures, and to educate the patient completely in every facet of denture use and upkeep, especially professional adjustment and correction.
Determination of some polyaromatic compounds by reversed-phase liquid chromatography with electrochemical detection

On montre que la detection amperometrique permet l'analyse des amines primaires aromatiques polycycliques en presence d'autres composes aromatiques polycycliques
The Couch Project

Carl Couch had a distinctive project. He was a man of distinctive character. In this commentary, I first describe the Couch project and then discuss how the project was interwoven with the character of its author. I then discuss “Oh, What Webs Those Phantoms Spin” in the context of Carl's larger project and close with a brief discussion of New Iowa School research after Carl Couch.
Mechanisms for the Extratropical QBO in Circulation and Ozone

Abstract A two-and-a-half-dimensional interactive stratospheric model (i.e., a zonally averaged dynamical-chemical model combined with a truncated spectral dynamical model), whose equatorial zonal wind was relaxed toward the observed Singapore zonal wind, was able to reproduce much of the observed quasi-biennial oscillation (QBO) variability in the column ozone, in its vertical distribution in the low and middle latitudes, and also in the high southern polar latitudes. To reveal the mechanisms responsible for producing the modeled QBO signal over the globe, several control runs were also performed. The authors find that the ozone variability in the lower stratosphere—and hence also in the column—is determined mainly by two dynamical mechanisms. In the low to midlatitudes it is created by a “direct QBO circulation.” Unlike the classic picture of a nonseasonal two-cell QBO circulation symmetric about the equator, a more correct picture is a direct QBO circulation that is strongly seasonal, driven by the sea...
Nuclear spectroscopy with energy resolution of a part per million

Abstract An instrument is described for producing a variable energy gamma ray beam with energy resolution of a part per million utilizing neutron capture gamma rays. The variation in energy is achieved through the recoil velocity of the radiating nucleus which has been excited by a gamma ray through the resonance fluorescence process. The instrument has been tested by exciting an energy level at 7.277 MeV in 208 Pb, also through the resonance fluorescence process, and it is shown that the line width Γ of the level can be measured. It is estimated that with a one MW reactor (neutron flux of 10 13 /cm 2 ·sec) one energy level per month can be studied using such an instrument.
Electrospun carbon nanofibers containing silicon particles as an energy-storage medium

A new energy-storage material has been developed by embedding Si nanoparticles as an alloying medium in electrospun carbon nanofibers. Anodes made from these carbon/Si composite nanofibers combine the advantages of both carbon (long cycle life) and Si (high lithium-storage capacity). They exhibit good electrochemical performance in terms of large reversible capacity, relatively good capacity retention and excellent rate capability upon insertion/extraction of lithium. As a result, they are promising anode candidates for storing energy in high performance batteries.
A review of using design patterns in CS1

For many years educators have tried to teach object-oriented programming using design patterns. Design patterns have brought with them an additional complexity that may be beyond the scope of entry-level programming courses. With a lot of effort and time some educators have developed courses where they have effectively taught the CS1 student with design patterns.
The Value of Nurse Leaders on Federal Advisory Panels Experience With the Agency for Healthcare Research and Quality

This article focuses on interviews with six nationally known nurse leaders who have been, or currently are, members of National Advisory Committee for the Healthcare Research and Quality (NAC). The nurse leaders are either deans and/or professors of schools of nursing. They discuss how their participation on the NAC serves the Federal Government and what they view as the benefits they now offer the nursing profession from being on the NAC such as an increased focus on evidence-based research. These nurse leaders also discuss what they bring to the table in terms of helping to influence public policy vis a vis health care quality, safety, and scientific evidence and their bearing on health care systems and services. They also talk about the myriad Federal opportunities that exist beyond this influential panel for nurse leaders to help continue shaping the future of health care.
A Learning-Based Framework for Engineering Feature-Oriented Self-Adaptive Software Systems

Self-adaptive software systems are capable of adjusting their behavior at runtime to achieve certain functional or quality-of-service goals. Often a representation that reflects the internal structure of the managed system is used to reason about its characteristics and make the appropriate adaptation decisions. However, runtime conditions can radically change the internal structure in ways that were not accounted for during their design. As a result, unanticipated changes at runtime that violate the assumptions made about the internal structure of the system could degrade the accuracy of the adaptation decisions. We present an approach for engineering self-adaptive software systems that brings about two innovations: 1) a feature-oriented approach for representing engineers' knowledge of adaptation choices that are deemed practical, and 2) an online learning-based approach for assessing and reasoning about adaptation decisions that does not require an explicit representation of the internal structure of the managed software system. Engineers' knowledge, represented in feature-models, adds structure to learning, which in turn makes online learning feasible. We present an empirical evaluation of the framework using a real-world self-adaptive software system. Results demonstrate the framework's ability to accurately learn the changing dynamics of the system while achieving efficient analysis and adaptation.
Associated multiplicity dependence of prompt positron production

Abstract Impact parameter correlations are shown to produce a rise in the e / π ratio with associated multiplicity in the production of pions accompanying low p 1 prompt positrons. The explicit multiplicity dependence is extracted from the data and compared with the Bjorken-Weisberg prediction.
Inaccuracy of intraocular lens power calculation after traumatic corneal laceration and cataract

A 53-year-old man sustained a perforating, central corneal injury with a nail in his right eye. After primary repair of the laceration, a traumatic cataract was removed and a Multiflex-style intraocular lens (IOL) was inserted. A 4.00 diopter surprise resulted, probably due to calculation of the IOL power using measurements from the contralateral normal eye. Inability to wear a contact lens for visual correction resulted in IOL exchange surgery in which a sulcus-sutured IOL was implanted. The IOL power was calculated using simulated keratometry from videokeratoscopy and axial length measurements of the injured eye. This resulted in an IOL power closer to emmetropia, allowing for a best spectacle-corrected visual acuity of 20/20 and comfortable wearing of spectacles.
Ambivalent Conquests: Maya and Spaniard in Yucatan, 1517‐1570

Ambivalent Conquests: Maya and Spaniard in Yucatan, 1517-1570. Inga Clendinnen. Cambridge: Cambridge University Press, 1987. xii. 243 pp., maps, appendices, glossary, notes, bibliography, index. $42.95 (cloth), $13.95 (paper). ISBN 0-521-33397-0, ISBN 0-521-37981-4.
Extended XQuery for digital libraries

Documents have, in general, a multihierarchical structure (such as physical organization in the form of pages and lines, content organization in the form of paragraphs and sentences, etc.). Searching multihierarchical XML encoding presents a number of unique challenges for both computer scientists and document experts. We present an extension of the XQuery language suitable for searching multihierarchical XML.
Efficacy of fluvoxamine in the treatment of major depression with comorbid anxiety disorders.

Background: Major depression with comorbid anxiety disorder is associated with poor antidepressant outcome compared with major depression without comorbid anxiety disorder. The purpose of our study was to assess changes in depressive symptoms and anxiety levels in outpatients with major depression with comorbid anxiety disorder following 12 weeks of open treatment with fluvoxamine. Method: We enrolled 30 outpatients (mean ± SD age = 39.4 ± 11.3 years; 16 women and 14 men) with DSM-IV major depressive disorder accompanied by one or more current comorbid DSM-IV anxiety disorders in our study. Patients were treated openly with fluvoxamine initiated at 50 mg/day, with an upward titration to a maximum of 200 mg/day (mean ± SD dose = 143 ± 45 mg/day). Efficacy assessments included the 17-item Hamilton Rating Scale for Depression (HAM-D-17) and Clinical Global Impressions-Severity of Illness (CGI-S) and Improvement (CGI-I) scales for both depression and anxiety. Intent-to-treat analysis was used to assess outcome. Results: The mean ± SD number of comorbid anxiety disorders per patient was 2. 1 ± 1.1. Following fluvoxamine treatment, the mean ± SD HAM-D-17 score dropped from 20.2 ± 3.3 to 11.0 ± 7.0 (p <.0001). The mean ± SD depression CGI-S score dropped from 4.0 ± 0.6 to 2.4 ± 1. 1 (p <.0001), and the mean ± SD anxiety CGI-S score decreased from 4.1 ± 0.8 to 2.5 ± 1.2 (p <.0001). Eighteen (60%) of the 30 patients had CGI-I scores ≤ 2 for both anxiety and depression at endpoint, with 53% showing a ≥ 50% reduction in HAM-D-17 scores at endpoint. Conclusion: Although preliminary, our findings suggest that fluvoxamine is effective in treating outpatients with major depression with comorbid anxiety disorder, having a significant effect on both depression and anxiety symptoms. Further double-blind, placebo-controlled trials are needed, in a larger sample, to confirm our findings.
Citric acid synthesis by the condensation of acetate and oxalacetate in rabbit kidney.

Abstract On incubation of rabbit kidney homogenates with C 14 carboxyl-labelled acetate, oxalacetate, Mg, adenosinetriphosphate, and malonate, there was formation of citric acid labelled with C 14 in the primary carboxyl carbon. In the absence of malonate there was some C 14 in the tertiary carboxyl carbon. These experiments demonstrate that the metabolism of acetate starts with its condensation with oxalacetate to form citrate, and subsequent oxidation through the Krebs cycle. The role of ATP is that of rendering labile the H of the CH 3 group of acetate, a process necessary for the condensation. This probably takes place by the formation of an ATP-acetate complex.
Compression of digitized map images

Abstract : The Air Force Mission Support System (AF MSS) will display digital images of navigational charts. The Defense Mapping Agency's (DMA) Equal Arc-Second Raster Chart (ARC) Digitized Raster Graphics (ADRG) products will be the primary source of data. System cost and performance goals require a storage reduction ratio of 48:1 for these images. This reduction will be obtained through a combination of spatial reduction, image compression, and color quantization. The AF MSS system specification admits many possible implementations at each step. Some combinations of options do not yield satisfactory results. This report describes a series of investigations into these three areas. We evaluate alternative algorithms, and identify a set of choices that offer the best image quality and performance, based on our prototype tests.
Asymmetry in the Distribution of Free versus Cytoskeletal Myosin II in Locomoting Microcapillary Endothelial Cells

Abstract Myosin II is required for normal amoeboid locomotion. In order to understand how myosin II elicits its effects on locomotive behavior, we have mapped myosin II–cytoskeleton interactions in locomoting endothelial cells. Bovine microcapillary endothelial cells were microinjected with fluorescently labeled myosin II, and the distribution of myosin II was imaged in the living cells by fluorescence microscopy. The same cells were then permeabilized with Triton X-100 and imaged again. The second set of images showed only myosin II that was associated with detergent-insoluble cytoskeleton. Dividing the image of retained myosin II by that of total myosin II produced a map of the extent to which myosin II was associated with the detergent-resistant cytoskeleton at any point in the cell. In cells migrating at the edge of a scrape wound, myosin II was preferentially retained in a region ∼10 μm wide located just behind the cells’ leading lamellipodia. Relatively little myosin II was retained in perinuclear cytoplasm. A vector representation of the distribution of total versus retained myosin II demonstrated that myosin II retention was sharply polarized with respect to locomotion, favoring the front of migrating cells. Myosin II-enriched cytoskeleton in this region may help polarize protrusive activity and/or move cytoplasmic bulk forward. Patches of myosin II retention were also observed in adherent tails of many cells, consistent with a role in pulling the rear of the cell forward.
The relative content of gibberellin in seedlings of gynoecious and monoecious cucumber (cucumis sativus)

Abstract Gibberellin A1 was isolated and identified from etiolated monoecious cucumber seedlings using paper, TLC and G-LC and bioassayed by utilizing dwarf pea, cucumber epicotyl, dwarf corn d1 and d5 plants. The gynoecious line, in which external application of GA3 accelerated staminate flower formation, contained less GA1. GA1 is possibly required for staminate flower formation in the monoecious, but not in the gynoecious line.
Improved discrete cosine transform picture coding by utilising extended Hamming codes

The authors explain how extended Hamming codes may be utilised for error protection of DCT coded pictures. The SNR graphs and the subjective examination of the images demonstrate the effectiveness of the technique.
Isopinocampheylborane derivatives with >99% ee via the DMAP complex.

The complex 8 of isopinocampheylborane and p-(dimethylamino)pyridine (DMAP) can be obtained with >99% ee starting from α-pinene with 80−90% ee by hydroboration using DMAP·BH3 (5) activated by 5% iodine, or by the conventional hydroboration of α-pinene, followed by addition of DMAP. Purification of the air-stable 8 is readily accomplished by crystallization from methanol. Conversion of 8 into the trifluoroborate adduct 1 using KHF2 occurs without erosion of ee. Generation of the derived 2 in situ with TMSCl as the fluorophile also occurs with little, if any, loss of ee, as evidenced by the preparation of the salicaldimine complex 11 and the derived amino alcohol 12 with 94% ee overall.
Statistical-kinematic analysis and limit equilibrium of systems with unilateral constraints

Abstract A general mechanical system involving unilateral constraints is studied and contrasted to a system with bilateral constraints. Some far-reaching consequences of their fundamental dissimilarity are revealed and explained. In particular, it is demonstrated that in the course of loading, a system with unilateral constraints can convert into a stationary (non-working) plastic mechanism. In this case the conventional version of the limit equilibrium method will miss the corresponding value of the load parameter. Therefore, certain precautions must be taken when applying the method, especially, in computer-assisted analysis.
Validation of a new predictive risk model for mortality using Framingham Heart Study data

Abstract Background The Institute for Health Metrics and Evaluation (IHME) developed a risk model to estimate 10-year mortality risk compared with a population with optimum risk factors in adults aged 30 years and older. IHME used data on exposure distributions of 12 behavioural and biometric risks in the US population, mortality rates by cause, and estimates of the proportional hazards of risk factor exposure from systematic reviews. The model has been validated using National Health and Nutrition Examination Survey (NHANES) data collected during 1988–94 and 1999–2004 (n=8331). Methods We will use data from participants attending the Framingham Heart Study (FHS) Offspring Examination 7 (1998–2001) and the Original Cohort Examination 20 (1986–90) to further validate the 10-year mortality risk model. These examinations were chosen since risk factors used in the IHME development mortality risk model were measured in these examinations. FHS participants aged 30 years and older at the time of examination will be included. Model performance will be assessed by (a) area under the curve to assess the ability of the model to discriminate between FHS participants who did and did not die within 10 years; and (b) Hosmer-Lemeshow goodness-of-fit tests comparing the FHS-observed mortality rate with the model-predicted mortality risk. Findings The FHS validation cohort consists of 3500 participants (mean age 62·4 years); 55% are women. Unlike NHANES, the FHS cohort sample is predominantly white. The FHS cohort is approximately 10·6 years (95% CI 10·1–11·1) older than NHANES, on average; FHS and NHANES have 55% and 53% females, respectively. The observed mortality rate is 14·3% (95% CI 13·2–15·5) in FHS and 8·4% (7·8–9·0) in NHANES cohort samples. We will present the findings of the validation on the FHS participants and compare with NHANES validation results. Interpretation Adequate performance of the risk model when applied to FHS, a sample with characteristics somewhat different from NHANES, will further support its validity and usefulness in the US population. Funding National Heart, Lungs and Blood Institute at the National Institutes of Health (2 N01-HC-25195-06).
Hanging out with the wrong crowd: how much difference can parents make in an urban environment?

This longitudinal study of youths growing up in an urban area tests whether and by how much increased levels of supervision and monitoring by parents might influence levels of affiliation with delinquent and deviant peers—possibly our most sturdily replicated proximal determinant of early-onset illegal drug use and associated conduct problems in adolescence, aside from aggression and rule-breaking in childhood. Standardized interviews were used to assess parenting, affiliation with deviant peers, and other characteristics of the urban-dwelling youths in this epidemiologically defined sample (>70% African American heritage). Longitudinal analyses and generalized estimating equation (GEE) methods were used to estimate prospective relationships across the transition from late childhood into early adolescence. Results from the longitudinal analyses showed that higher levels of monitoring signaled later lower levels of affiliation with deviant peers, even with statistical adjustment for multiple covariates (\=−0.04; 95% confidence interval [CI]=−0.07 to −0.02; P=.001). Closer parental supervision at ages 8–9 years was linked to subsequently lower levels of deviant peer affiliation (\=−0.05; 95% CI=−0.08 to −0.01), and subsequent age-associated increases in levels of parental supervision from year to year were followed by decreases in levels of affiliation with deviant peers (\=−0.12; 95% CI=−0.15 to −0.09). The main evidence from this study indicates that maintenance of parental supervision and monitoring through the transition from childhood to adolescence may yield important reductions in levels of affiliation with deviant peers, even in the context of our urban and sometimes socially disadvantaged community environments.
Multitrait–multimethod matrix validation of the Negative Mood Regulation Scale

Abstract A multitrait–multimethod matrix tested the validity of the Negative Mood Regulation (NMR) Scale. Participants were 74 first-semester freshmen and transfer college students who completed the NMR Scale and measures of adaptation to college, depression and loneliness. A parent, roommate or friend also rated each participant on these four variables. Thus, all four constructs were assessed by self-report and other-ratings. The NMR Scale satisfied three of four criteria of validity. Its monotrait–heteromethod correlation was significant, and this value was higher than its heterotrait–heteromethod and total heterotrait values. Additionally, regressions that controlled shared method variance yielded significant heteromethod associations between the NMR Scale and its corresponding other-rating. These results add to the nomological net for the NMR construct.
Identification of Members of the Metabolically Active Microbial Populations Associated with Beggiatoa Species Mat Communities from Gulf of Mexico Cold-Seep Sediments

In this study, the composition of the metabolically active fraction of the microbial community occurring in Gulf of Mexico marine sediments (water depth, 550 to 575 m) with overlying filamentous bacterial mats was determined. The mats were mainly composed of either orange- or white-pigmented Beggiatoa spp. Complementary 16S ribosomal DNA (crDNA) was obtained from rRNA extracted from three different sediment depths (0 to 2, 6 to 8, and 10 to 12 cm) that had been subjected to reverse transcription-PCR amplification. Domain-specific 16S PCR primers were used to construct 12 different 16S crDNA libraries containing 333 Archaea and 329 Bacteria clones. Analysis of the Archaea clones indicated that all sediment depths associated with overlying orange- and white-pigmented microbial mats were almost exclusively dominated by ANME-2 (95% of total Archaea clones), a lineage related to the methanogenic order Methanosarcinales. In contrast, bacterial diversity was considerably higher, with the dominant phylotype varying by sediment depth. An equivalent number of clones detected at 0 to 2 cm, representing a total of 93%, were related to the γ and δ classes of Proteobacteria, whereas clones related to δ-Proteobacteria dominated the metabolically active fraction of the bacterial community occurring at 6 to 8 cm (79%) and 10 to 12 cm (85%). This is the first phylogenetics-based evaluation of the presumptive metabolically active fraction of the Bacteria and Archaea community structure investigated along a sediment depth profile in the northern Gulf of Mexico, a hydrocarbon-rich cold-seep region.
Correlates of teacher ratings, sustained attention, and impulsivity in hyperactive and normal boys

The purpose of the present research was to determine whether teacher ratings of classroom behavior reflect the attentional and impulsivity components of hyperactivity as set forth in the diagnostic criteria of the Diagnostic and Statistical Manual of Mental Disorders. To accomplish this purpose, the present study assessed whether ratings on the Conners Teacher Questionnaire corresponded to psychometric measures of attention and impulsivity in hyperactive and nonhyperactive males. Thirty boys were rated by their teachers for hyperactivity in the classroom and administered a series of psychometric tests designed to measure sustained attention and impulse control. Teacher ratings of hyperactivity were found to correlate significantly with measures of attention and impulsivity suggesting that teachers, in their use of the Conners scale, are able to discriminate children with deficits in attention and impulse control from their normal peers in the classroom setting. The findings of moderately significant corre...
Efficient reservoir history matching using subspace vectors

In this paper, we describe a method of history matching in which changes to the reservoir model are constructed from a limited set of basis vectors. The purpose of this reparameterization is to reduce the cost of a Newton iteration, without altering the final estimate of model parameters and without substantially slowing the rate of convergence. The utility of a subspace method depends on several factors, including the choice and number of the subspace vectors to be used. Computational gains in efficiency result partly from a reduction in the size of the matrix system that must be solved in a Newton iteration. More important contributions, however, result from a reduction in the number of sensitivity coefficients that must be computed, reduction in the dimensions of the matrices that must be multiplied, and elimination of matrix products involving the inverse of the prior model covariance matrix. These factors affect the efficiency of each Newton iteration. Although computation of the optimal set of subspace vectors may be expensive, we show that the rate of convergence and the final results are somewhat insensitive to the choice of subspace vectors. We also show that it is desirable to start with a small number of subspace vectors and gradually increase the number at each Newton iteration until an acceptable level of data mismatch is obtained.
Blood pressure targets in patients with coronary artery disease: observations from traditional and Bayesian random effects meta-analysis of randomised trials

Context Most guidelines for treatment of hypertension including the Joint National Committee-7 recommend a blood pressure (BP) goal of Objective To evaluate the BP targets in patients with CAD Data Sources PUBMED, EMBASE and CENTRAL Study Selection: Randomised clinical trials (RCTs) of antihypertensive therapy in patients with CAD, enrolling at least 100 patients, with achieved systolic pressure of Data Extraction The following efficacy outcomes were extracted- all-cause mortality, cardiovascular mortality, myocardial infarction, stroke, angina pectoris, heart failure and revascularisation. Results We identified 15 RCTs enrolling 66 504 participants with 276 328 patient-years of follow-up. Intensive BP group (≤135 mm Hg) was associated with a 15% decrease in heart failure rate and 10% decrease in stroke rate, driven largely by trials with a more intensive BP group (≤130 mm Hg), with similar outcomes for death and cardiovascular death and was associated with a 105% increase in the risk of hypotension. More intensive BP group (≤130 mm Hg) was also associated with a reduction in myocardial infarction and angina pectoris. The results were similar in a Bayesian random effects model. In addition, lower seemed to be better (based on regression analysis) for the outcomes of myocardial infarction, stroke, heart failure and perhaps angina. Conclusions The present body of evidence suggests that in patients with CAD, intensive systolic BP control to ≤135 mm Hg and possibly to ≤130 mm Hg is associated with a modest reduction in stroke and heart failure but at the expense of hypotension. Lower was better, although not consistently so for myocardial infarction, stroke, heart failure and perhaps angina. Further trials are needed to prove these findings.
Antioxidant supplementation in prevention and treatment of immune dysfunction and oxidation induced by murine aids in old mice

Abstract Old female C57BL6 mice were infected with LP-BM5 retrovirus which caused murine AIDS with supplementatin. Multiple antioxidants significantly normalized Th1 (IL-2) and Th2 (IL-4, IL-6) cells' cytokine production in vitro with restoration of T- and B-cell mitogenesis. It also restored hepatic vitamin E level, which had been reduced by retrovirus infection. To assert whether the amount of retrovirus inoculum would accelerate development of immune dysfunction, some mice were injected with three times the usual infectious dose. There was no significant difference in immune parameters nor was premature death accelerated. Supplementation for 1.5 months begun as murine AIDS was developing, did not significantly prevent dysfunction in cytokine secretion, loss of hepatic vitamin E, nor reduction in T- and B-cell mitogenesis in mice given either infectious dose level.
Erosion Characterization of Coated Superalloys in Turbomachinery Applications

The ingestion of suspended particles by high performance turbomachinery reduces engine efficiency and life. New developments in blade coating materials have contributed to compressor and turbine design improvements. A knowledge of the important phenomna associated with material erosion by particulate flow is required in the design. This paper gives an overview of the experimental studies of the erosion characteristics of coated superalloy blades conducted at the University of Cincinnati’s test facilities for blade and coating materials erosion will be described. Results will be presented and discussed for the erosion characteristics of various blade materials and coatings. The investigated coatings are produced via plasma spray, detonation guns, chemical vapor deposition (CVD), and physical vapor deposition (PVD).Copyright © 2002 by ASME
Bone tumor reconstruction with the Ilizarov method.

Background and Objectives Patients with musculoskeletal tumors can face large bone deficiency, deformity, and nonunion. Distraction osteogenesis via the Ilizarov method may be useful for reconstruction of these deficiencies allowing limb preservation and optimizing function. Methods We reviewed 20 patients with a range of musculoskeletal tumors necessitating surgical treatment. The group included 9 females and 11 males with a mean age of 22.6 (8–58) years at a mean follow up of 81.7 (26–131) months. The mean bone deficiency was 7.9 (1.2–18.0) cm. Results The mean lengthening achieved was 7.1 (3.5–18.0) cm over an EFI of 33.5 (range, 9.5–58.3) days/cm. This treatment resulted in 10 excellent and 3 good ASAMI bone scores, 10 excellent and 3 good ASAMI function scores, a mean lower extremity MSTS score of 93% and a mean upper extremity MSTS score of 87%. Treatment resulted in 2 complications, 18 obstacles, and 6 problems. Conclusion The Ilizarov method is an effective technique for limb reconstruction of bone tumors, although extended time in external fixation is required. Since no one in this group received simultaneous chemotherapy or radiotherapy, we cannot comment on use of the Ilizarov method with these treatments. Further use and clinical follow-up is warranted. J. Surg. Oncol. 2013;107:343–352. © 2012 Wiley Periodicals, Inc.
mTORC1 status dictates tumor response to targeted therapeutics

Genomics has revolutionized and personalized our approach to cancer therapy, with clinical trials now frequently involving patient stratification based on tumor genotype. Rational drug design specifically targeting the most common genetic events and aberrantly regulated pathways in human cancers makes this approach possible. However, our understanding of the wiring of oncogenic signaling networks and the key downstream effectors driving human cancers is incomplete, limiting our ability to predict clinical responses or identify mechanisms of resistance to targeted therapeutics. Recent studies in independent cancer lineages driven by distinct oncogenic signaling events point to a common downstream target, the mammalian (or mechanistic) target of rapamycin complex 1 (mTORC1), which dictates the cellular and clinical response to pathway-specific inhibitors. mTORC1 is a highly integrated signaling node that promotes anabolic cell growth and proliferation and lies downstream of multiple oncogenes and tumor suppressors, including those influencing the PI3K-Akt and RAS-RAF-MEK-ERK pathways. Studies are now suggesting that to effectively target the major oncogenic signaling pathway in a given tumor, mTORC1 must be inhibited, and that its sustained activation is a major mechanism of resistance to such targeted therapies.
What’s Love Got to Do with It? A Longitudinal Study of the Culture of Companionate Love and Employee and Client Outcomes in a Long-term Care Setting:

In this longitudinal study, we build a theory of a culture of companionate love—feelings of affection, compassion, caring, and tenderness for others—at work, examining the culture’s influence on ou...
Autoregulatory Response and CO2 Reactivity of the Basilar Artery

Background and Purpose— Transcranial Doppler has been extensively used to measure cerebrovascular control mechanisms, including autoregulation in humans and in patients with cerebrovascular diseases. There have been sufficient reports on the measurement of normal autoregulatory response (AR) and CO2 reactivity (CR) of the middle cerebral artery (MCA) but few reports of these indices for the basilar artery (BA). We measured AR and CR in the BA in healthy volunteers to determine normal values and compared them with simultaneous measurements made in the MCA. Methods— Sixteen normal subjects were enrolled. Time-averaged mean velocities of maximum blood flow in the BA and MCA were continuously and simultaneously monitored by using transcranial Doppler along with continuous measurement of mean arterial blood pressure (MABP). Values were obtained during rest, alterations of end-tidal Paco2 (ETCO2), and acute decrease and recovery of MABP. AR was evaluated by using the thigh cuff method and graded by the standard...
Electron spin resonance study of the phase transitions in barium titanate

Abstract The Fe 3+ EPR spectrum at X-band in BaTiO 3 has been used as a vehicle to study the cubic-tetragonal and tetragonal-orthorhombic phase transitions. There is an abrupt change in the spectrum at both transitions. Since transitions to the tetragonal phase from either of the adjoining phases can be accomplished by the application of a strong electric field, one should be able to produce a considerable change in the EPR spectrum. Previous attempts to do this have not been successful. (5) Operating at temperatures just above the cubic-tetragonal transition, as well as within the temperature hysteresis region of the tetragonal-orthorhombic transition, with properly prepared electrodes we have been able to induce the tetragonal spectrum with an applied electric field. In the absence of a field the transition between orthorhombic and tetragonal phases with increasing temperature s discontinuous. This discrepancy with the spontaneous polarization data is discussed.
Oral Lichenoid Lesions Associated With Dental Amalgam Restorations: A 60-Year-Old Woman With a 7-Year History of Painful, Erosive Mucosal Lesions

CASE PRESENTATION but had never been formally tested for this problem.She A 60-year-old white woman was first seen in the Oral Medicine Clinical Service with a chief complaint of persistent oral lesions. The patient had been experiencing recurrent mouth sores for at least 7 years, but had decided that these were ‘‘canker sores.’’ Because they were only mildly troubling, she had not sought care for them, and had instead used over-thecounter remedies. She had been recently examined in the School of Dentistry’s ‘‘new patient’’ assessment clinic, and during that visit had been made aware that her oral lesions warranted follow-up. She was referred to the Oral Medicine Clinical Service to evaluate these lesions.
Deep space autonomous network using reverse channel for congestion control

The extremely long propagation delay between interplanetary nodes poses challenges to the investigation of Store-and-forward Deep Space Autonomous Network (DSAN). Long propagation delay combined with scarcity of energy at the planetary wireless nodes and relays, introduces new dimensions to the congestion control challenge. In this paper, we take advantage of long propagation delay between nodes and propose a novel approach for congestion control. The long delayed channel can be utilized as a memory resource. Instead of dropping the packets due to lack of storage at the intermediate nodes such as satellite or a robotic spacecraft, they are transmitted back to the source. This significantly reduces packet loss, and lowers the per packet energy consumption. In addition, this method provides feedback on the congestion status of the relay node. Consequently, the source is able to dynamically control traffic flow in the source-relay channel until congestion is abated. Two proposed protocols, i.e., (i) reverse channel (without rate control) and (ii) reverse channel with rate control are investigated, and compared with a conventional protocol where no reverse channel is utilized. Extensive simulations are conducted which validate that the performance with reverse channel, especially reverse channel with rate control, far outweigh the conventional approach, in terms of energy consumption, and retransmission per successful packet.
High-Resolution Optical Coherence Tomography-Guided Laser Ablation of Surgical Tissue

Background. Optical coherence tomography (OCT) is a compact high-speed imaging technology which uses infrared light to acquire cross-sectional images of tissue on the micrometer scale. Because OCT images are based on the optical backscattering properties of tissue, changes in tissue optical properties due to surgical laser ablation should be detectable using this technique. In this work, we examine the feasibility of using real-time OCT imaging to guide the placement and observe the dynamics of surgical laser ablation in a variety of tissue types. Materials and methods. More than 65 sites on five ex vivo rat organ tissue types were imaged at eight frames per second before, during, and after laser ablation. Ablation was performed with a coincident continuous wave argon laser operating at 514-nm wavelength and varying exposure powers and durations. Following imaging, tissue registration was achieved using microinjections of dye followed by routine histologic processing to confirm the morphology of the ablation site. Results. High-speed OCT imaging at eight frames per second permitted rapid tissue orientation and guided ablation in numerous organ specimens. Acquisition rates were fast enough to capture dynamic changes in optical backscatter which corresponded to thermal tissue damage during laser ablation. Conclusions. The ability of high-resolution highspeed OCT to guide laser ablation and image the dynamic changes suggests a role in image-guided surgical procedures, such as the ablation of neoplasms. Future in vivo studies are necessary to demonstrate performance intraoperatively. © 1999 Academic Press
A cGMP-dependent protein kinase (PKG) controls synaptic transmission tolerance to acute oxidative stress at the Drosophila larval neuromuscular junction.

Increasing evidence demonstrates that modulating the cGMP-dependent protein kinase G (PKG) pathway produces an array of behavioral phenotypes in the fruit fly, Drosophila melanogaster. Altering PKG...
Computational identification of adaptive mutants using the VERT system.

Background Evolutionary dynamics of microbial organisms can now be visualized using the Visualizing Evolution in Real Time (VERT) system, in which several isogenic strains expressing different fluorescent proteins compete during adaptive evolution and are tracked using fluorescent cell sorting to construct a population history over time. Mutations conferring enhanced growth rates can be detected by observing changes in the fluorescent population proportions.
Support for Food and Beverage Worksite Wellness Strategies and Sugar-Sweetened Beverage Intake Among Employed U.S. Adults.

Abstract Purpose. Sugar-sweetened beverage (SSB) consumption is high among U.S. adults and is associated with obesity. Given that more than 100 million Americans consume food or beverages at work daily, the worksite may be a venue for interventions to reduce SSB consumption. However, the level of support for these interventions is unknown. We examined associations between workday SSB intake and employees' support for worksite wellness strategies (WWSs). Design. We conducted a cross-sectional study using data from Web-based annual surveys that gather information on health-related attitudes and behaviors. Setting. Study setting was the United States. Subjects. A total of 1924 employed adults (≥18 years) selected using probability-based sampling. Measures. The self-reported independent variable was workday SSB intake (0, <1 or ≥1 times per day), and dependent variables were employees' support (yes/no) for the following WWSs: (1) accessible free water, (2) affordable healthy food/drink, (3) available healthy ...
SEAWALL OVERTOPPING MODEL

Results from an extensive series of laboratory tests of irregular wave overtopping for a number of seawall and seawall/revetment configurations is presented. Data for 13 configurations has been collected and grouped into 7 data sets representing relatively similar geometrical characteristics. All data sets showed an approximately exponential relationship between the overtopping rate and a dimensionless freeboard parameter which is the ratio of the seawall freeboard to the local wave severity. This finding logically led to the development of three progressively more complex overtopping models. The models provide a relatively simple way to estimate overtopping rates and an objective way to evaluate the hydraulic performance of seawalls/revetments. Advantages and disadvantages of the models are discussed and their ability to predict overtopping rates is compared.
External Environments: Distributed Data Repositories

We use the term External Environments to refer to the essential interfaces to remote computational resources (e.g. data repositories, real time data streams, high performance networks, and computing clouds) that advanced applications may need to access and utilize. The use of such resources is already typical for many high-end applications and they form a critical part of the working environment for most, if not all, major research communities. In the following, the External Environment Distributed data repositories is discussed as a contribution to the International Exascale Software Project (IESP).
Surgical treatment of solid facial edema : When everything else fails

A case of persistent solid facial edema is presented to illustrate and discuss this rare, poorly understood condition. It is most frequently a sequela of acne vulgaris, but it can also be caused by other congenital, infectious, and inflammatory processes. This entity is notoriously difficult to treat. Many therapeutic modalities have been tried. Early treatments with isotretinoin, clofazimine, and ketotifen have been occasionally effective while no treatment has been proven successful in the later stages. This is probably the first time that surgical treatment of this problem has been reported. This experience and a review of the literature may prove helpful to other practitioners in our specialty.
Contrast-Enhanced Abdominal MRI for Suspected Appendicitis: How We Do It.

OBJECTIVE. The purpose of this article is to describe our approach to contrast-enhanced abdominal MRI in patients with nontraumatic abdominal pain and suspected appendicitis. We aim to share our experience on the advantages, pearls, and pitfalls of MRI in this clinical setting, in comparison with CT and ultrasound. CONCLUSION. We present some typical cases of appendicitis and alternative diagnoses in patients presenting with acute nontraumatic abdominal pain.
Consumption of sound and decayed ponderosa pine and Douglas-fir by Reticulitermes spp. (Isoptera: Rhinotermitidae) from northern California.

Survival, amount of wood consumed, and the feeding rate of workers of western subterranean termites, Reticulitermes spp., were assessed on sapwood blocks of ponderosa pine, Pinus ponderosa Dougl. ex Laws, and Douglas-fir, Pseudotsuga menziesii (Mirb.) Franco, that were sound or decayed by 1 of 2 brown-rot fungi, Gloeophylum trabeum (Fr.) Murr. or Postia placenta (Fr.) M. Lars & Lomb. Groups of 200 workers were confined separately on combinations of each wood and fungal species for 28 d. Mean survivorship of2 colonies was 89.5 and 96.1%, and were not significantly different, whereas 1 of these suffered significantly greater mortality when fed wood of either species decayed by G. trabeum. Groups of workers consumed an average of 293 mg or 25.5% of wood during the test period. The amount and percentage of wood consumed by termites was significantly greater when decayed by either fungus; however, 1 colony consumed significantly more wood of both species when decayed by G. trabeum. When corrected for mortality over the length of the test, feeding (milligrams wood per worker per 28 d) was not significantly different between colonies or wood species. Wood of either species was consumed at a significantly greater rate if decayed by G. trabeum (1.77 mg per termite per 28 d) than by P. placenta (1.55 mg per termite per 28 d); wood decayed by either fungus was consumed at a significantly greater rate than nondecayed wood (1.25 mg per termite per 28 d).
The New Device Interrupting Short Circuit Current With Super High Speed——DXK1 Series Fault Current Limiter

This paper introduces the principle, structure, performance and application of a new electric equipment-DXK1 series fault current limiter that can interrupt the specially heavy current of power system with super high speed. The device has the obvious effect of energy saving and environment protection.
Consideration of Adjusting the Punishment against Enviroment Violations

The purpose of this article is to analyze the issues founded when dealing with the current environmental violations, to investigate diligently all aspects of the handling process, and to put forward some opinions and views upon how to solve these issues. Furthermore, this article, combining with the practical daily work, is to discuss the enforcement of penalties for violations, which is the most important and difficult point during the execution process. That is, in order to crack down the environmental violations, the administrative punishment should be combined with the criminal punishment. This is the only way for the offenders to be duly punished, and therefore to prevent the pollution from occurring, punish acts of pollution, and construct the environment-friendly society which is the ultimate goal of our environment protection activities.
Investigation and disposal of an event of dog bit students

Objective To learn about causes of dog bit students,so as to reduce the occurrence of such events.Methods Inquiry,field investigation and the dog wound disposal were implemented.Results 9 students were bitten,including 2 males and 7 females,who were all distal lower extremity woundⅢexposure.Conclusions Standard management after exposure of rabies is crucial,and psychological guidance and health education for students can not be ignored;The school should strictly guard dogs to enter,thus prevent the occurrence of events from the source.
Phobia: types, dynamics and treatments.

Phobic symptoms were discussed in different types of personalities: ‘normal’, psychoneurotic, and psychotic. The psychodynamics were different in each; also the suggested treatment was different. T...