cssi/SciSciGPT-SciSciNet huggingface dataset:
Decentralized degree regularization for multi-agent networks

Networked multi-agent systems are widely modeled as graphs where the agents are represented as nodes and edges exist between the agents that interact directly. In this setting, the degree of a node is the number of edges incident to it. For such systems, degree regularity (uniformity of degree across the nodes) typically provides desirable properties such as robustness and fast mixing time. As such, a key task is to achieve degree regularization in a decentralized manner. In this paper, we present a locally applicable rule that achieves this task. For any connected initial graph, the proposed reconfiguration rule preserves the graph connectivity and the total number of edges in the system while minimizing the difference between the maximum and the minimum node degrees.
Tamoxifen inhibits uptake and metabolism of ethanolamine and choline in multidrug‐resistant, but not in drug‐sensitive, MCF‐7 human breast carcinoma cells

Abstract Tamoxifen (TAM), a widely used agent in the hormonal therapy of breast cancer, is also an antagonist of P-glycoprotein (P-gp), a cell surface protein which confers drug resistance to cells. Here we report that in an estrogen receptor-deficient multidrug-resistant subline of MCF-7 human breast carcinoma cells (MCF-7/MDR), but not in the parent drug-sensitive cells (MCF-7/WT), clinically relevant concentrations (1–5 μM) of TAM inhibited the uptake and phosphorylation of ethanolamine and choline. These inhibitory effects resulted in decreased synthesis of the corresponding phospholipids. In view of the known dependence of P-gp function of phosphatidylethanolamine (PtdEtn), inhibition of PtdEtn synthesis may represent an additional mechanism by which TAM inhibits P-gp-mediated drug efflux.
The Adjective Check List applied to older institutionalized men.

Summary The assessment of the personality of the institutionalized aged presents many difficulties, since not all are capable of responding to the usual inventories. The Adjective Check List (ACL) has been considered a simple, flexible technique overcoming these difficulties. Seventy older men were evaluated on the ACL through self-reports and reports of their supervisors. Residents with disciplinary problems were described on a number of dimensions including aggression and need for change. Intelligence-personality relationships were found that were consistent with those found in children. The method appears capable of eliciting the negative self-perceptions of those who have early institutionalization.
Some dietary principles in digestive diseases.

Every therapeutic diet should approximate normal and optimal nutrition as nearly as possible and lead back to as nearly a full diet as can be accepted. Both hospital patients and out-patients require a well-thoughtout and individually-constructed basic food program which recognizes as far as possible the tastes and idiosyncrasies of the person himself. The gastrointestinal patient who is out of control ordinarily presents a confused and frustrated personality, and part of his “diet” should consist of psychotherapeutic tid-bits and even substantial sermons. Conferring upon him the power of self-help should be the constant purpose of each professional contact. Without psychosomatic adjustments, diets by themselves may prove only partially effective.
R69-9 Deterministic Stack Automata and the Quotient Operator

Stack automata1were introduced because they generalize the notion of a push-down store by allowing the interior of the push-down lost to be read but not changed. It turns out that this is an important family of automata for theoretical purposes. The original model included one-way and two-way, deterministic and nondeterministic versions.
Intermittent single-molecule interfacial electron transfer dynamics.

We report on single-molecule studies of photosensitized interfacial electron transfer (ET) processes in Coumarin 343 (C343)−TiO2 nanoparticles (NP) and Cresyl Violet (CV+)−TiO2 NP systems, using time-correlated single-photon counting coupled with scanning confocal fluorescence microscopy. Fluorescence intensity trajectories of individual dye molecules adsorbed on a semiconductor NP surface showed fluorescence fluctuations and blinking, with time constants distributed from milliseconds to seconds. The fluorescence fluctuation dynamics were found to be inhomogeneous from molecule to molecule and from time to time, showing significant static and dynamic disorders in the interfacial ET reaction dynamics. We attribute fluorescence fluctuations to the interfacial ET reaction rate fluctuations, associating redox reactivity intermittency with the fluctuations of molecule−TiO2 electronic and Franck−Condon coupling. Intermittent interfacial ET dynamics of individual molecules could be characteristic of a surface ch...
Assessing Risk for Drug Overdose in a National Cohort: Role for Both Daily and Total Opioid Dose?

Abstract Current research on the risk of opioid analgesics with drug overdose does not account for the total morphine equivalent dose (MED) of opioids filled by a patient. In this study, time from first opioid prescription until drug overdose was examined for 206,869 privately insured patients aged 18 to 64 with noncancer pain and ≥2 filled prescriptions for Schedule II or III opioids from January 2009 to July 2012. Opioid therapy was examined in 6-month intervals including 6 months before an overdose and categorized as mean daily MED (0, 1–19, 20–49, 50–99, ≥100 mg) and total MED divided at top quartile (0, 1–1,830, >1,830 mg). Survival analysis was used, adjusting for demographics, clinical conditions, and psychoactive drugs. Relative to no opioid therapy, persons at highest risk for overdose (adjusted hazard ratios of 2–3) received a daily MED of ≥100 mg regardless of total dose or a daily MED of 50 to 99 mg with a high total MED (>1,830 mg). The hazard ratio was significantly lower (1.43, 95% confidence interval = 1.15–1.79) for 50 to 99 mg daily MED with a lower total MED (≤1,830 mg), whereas hazard ratios for lower daily MEDs did not differ by total dose. This analysis suggests that clinicians should consider total MED to assess risk of overdose for persons prescribed 50 to 99 mg daily MED. Perspective When addressing risks for drug overdose, this analysis supports the need for clinicians, administrators, and policy makers to monitor not only daily opioid dose but also total dose for patients receiving 50 to 99 mg daily MED.
Direct Extraction of the Eliashberg Function for Electron-Phonon Coupling: A Case Study of Be(1010)

We propose a systematic procedure to directly extract the Eliashberg function for electron-phonon coupling from high-resolution angle-resolved photoemission measurement. The procedure is successfully applied to the $\mathrm{Be}(10\overline{1}0)$ surface, providing new insights into electron-phonon coupling at this surface. The method is shown to be robust against imperfections in experimental data and suitable for wider applications.
Neurofascin interactions play a critical role in clustering sodium channels, ankyrinG and βIV spectrin at peripheral nodes of Ranvier

Abstract The Ig cell adhesion molecules (CAM) neurofascin (NF) and Nr-CAM are localized at developing nodes of Ranvier in peripheral myelinated axons prior to clustering of Na + channels. Different isoforms of NF are expressed on neurons and glia, and NF binding on both cells has been suggested to play roles in node and paranode formation. To clarify the role of NF further, we analyzed effects of NF-Fc fusion proteins in Schwann cell–DRG neuron myelinating cocultures. NF-Fc significantly inhibited nodal clustering of Na + channels, ankyrin G , and βIV spectrin, and modestly reduced Caspr clustering at paranodal junctions; it did not significantly affect lengths or numbers of myelin-positive segments, axon initial segments, or accumulations of phosphorylated-ERM proteins in Schwann cell nodal microvilli. NF-Fc binds to Schwann cells but little or no binding to DRG neurons was detected. The results suggest a critical early role for axonal NF in clustering of Na + channels at nodes of Ranvier via interactions with receptors on Schwann cells.
A computational study of the possible isomers and conformations of N-trifluoromethylformamide, CF3NHC(O)H, and N-hydroxymethylidenetrifluoromethylamine, CF3NC(H)OH

Abstract A semiempirical and ab initio study of the possible isomers and conformers of both CF3NHC(O)H and CF3NC(H)OH as well as the barriers to interconversion between them was carried out. All possible geometries were fully optimized in Cs symmetry with the mopac and gaussian programs. Both the semiempirical and ab initio calculations reproduced the experimental ordering of energies, i.e. all isomers and conformers of the formamide were found to be more stable than those of the imime. In addition, transition states between the isomers were found and the barriers to isomerization based on these calculations are in good agreement with experimental data.
Use of Atomoxetine in a Patient with Fibromyalgia Syndrome and Attention-Deficit Hyperactivity Disorder

Background: We describe a 65-year-old patient with adult attention deficit hyperactivity disorder [ADHD], poorly controlled by adderall XR, and generalized pain from fibromyalgia syndrome [FMS]. The patient's pain did not respond to amitriyptyline, lidoderm patch, percocet, diazepam, metaxalone, ibuprofen, or gabapentin.Findings: Her pain related to FMS responded dramatically to atomoxetine, a selective norepinephrine reuptake inhibitor approved by the Food and Drug Administration for ADHD treatment, which was substituted for adderall XR in this patient. The patient reported a 60 percent pain reduction and marked improvement of her functional status, as well as improvement regarding her ADHD.Conclusions: We suggest that atomoxetine might be a useful adjunct in the treatment of FMS, and possibly neuropathic pain conditions.
EPR oximetry in the beating heart: myocardial oxygen consumption rate as an index of postischemic recovery.

Oxygen plays a critical role in the pathophysiology of myocardial injury during both ischemia and subsequent reperfusion (I/R). Thus, oxygen concentration is an important variable to measure during I/R. In the present work, electron paramagnetic resonance (EPR)-based oximetry was used to measure the oxygen concentration during a series of I/R episodes and oxygenation levels were correlated with the contractile and hemodynamic functions of the heart. A custom-developed electronically tunable surface coil resonator working at 1.1 GHz was used to determine tissue pO2 in the beating heart. Microcrystalline particulate of lithium phthalocyanine was used as an EPR oximetry probe. Isolated and perfused rat hearts were subjected to 1 or 3 hr durations of preischemic perfusion, followed by 15-min I/R cycles. In hearts perfused for 3 hr prior to 15-min I/R cycles, the myocardial pO2 decreased gradually on subsequent reperfusions of three successive I/R cycles. However, in hearts perfused for 1 hr there was almost 100% recovery of myocardial pO2 in all three I/R cycles. The extent of oxygenation recovered in each reperfusion cycle correlated with the recovery of hemodynamic and contractile function. The results also showed that the oxygen consumption rate of the heart at the end of each I/R episode decreased in direct proportion to the functional recovery. In summary, it was observed that the amount of myocardial oxygen consumption during I/R could provide a reliable index of functional impairment in the heart. Magn Reson Med 51:835–842, 2004. © 2004 Wiley-Liss, Inc.
Optical Transitions And Enhanced Recombination Lifetimes In Quasi-Zero Dimensional Electron System In CdS x Se 1-x

The recombination lifetimes for the radial and angular quantum number conserving 1S→1S and 1P→1P transitions from three-dimensionally confined electrons in CdSxSel-x were measured by time-resolved photoluminescence. The assignment of the observed transitions is supported by calculations of eigen energy levels, squared matrix element ratio for those transitions, steady-state and picosecond spectroscopic studies.
Advances in composite materials for thermal management in electronic packaging

A variety of new advanced composite materials are now available that provide great advantages over conventional materials for electronic packaging thermal control, including extremely high thermal conductivities (more than twice that of copper); low tailorable coefficients of thermal expansion; weight savings up to 80 percent; extremely high strength and stiffness; low-cost, net-shape fabrication processes; and cost reductions as high as 65 percent. In addition, composites are in a state of continual development that will provide even greater benefits. This article provides an overview of advanced composites used in thermal management, including properties, applications, and future trends. The focus is on materials having thermal conductivities at least as high as those of aluminum alloys. Future trends and the potential for composites in other aspects of the electronics industry, such as high-speed assembly machine materials of construction, are also examined.
Optical properties and photoexcitation of a novel liquid form of soluble polyacetylene

Optical absorption, fluorescence emission, Raman scattering, and time-resolved emission experiments are reported on a new liquid form of soluble polyacetylene. This liquid consists of separate polyene chains, grown on activated sites of a polybutadiene chain. The depolarization ratios as well as the time-resolved spectrum of the secondary emission were measured. The relevant spectral features are discussed and analyzed in terms of the lack of interchain interactions which characterize the polymer in solution.
Adiposity, type 2 diabetes and the metabolic syndrome in breast cancer

Upper body obesity and the related metabolic disorder type 2 diabetes have been identified as risk factors for breast cancer, and associated with late-stage disease and a poor prognosis. Components of the metabolic syndrome, including visceral adiposity, insulin resistance, hyperglycemia and hyperinsulinemia, with or without clinically manifest diabetes mellitus, low serum high-density lipoprotein cholesterol and hypertension have all been related to increased breast cancer risk. The biochemical mechanisms include extraglandular oestrogen production, reduced sex hormone-binding globulin with consequent elevation of the bioactive plasma free oestradiol and increased insulin biosynthesis, all of which exert mitogenic effects on both untransformed and neoplastic breast epithelial cells. Obesity, type 2 diabetes and the metabolic syndrome also have in common an increased production of leptin and a decreased production of adiponectin by adipose tissue, with consequent elevations and reductions, respectively, in the circulating levels of these two adipokines. These changes in plasma leptin and adiponectin, acting through endocrine and paracrine mechanisms, have been associated in several studies with an increase in breast cancer risk and, perhaps, to more aggressive tumours; studies in vitro showed that leptin stimulates, and adiponectin inhibits, tumour cell proliferation and the microvessel angiogenesis which is essential for breast cancer development and progression.
Analysis of EPR powder pattern lineshapes for Mn(II) including third-order perturbation corrections. Applications to Mn(II) complexes with enzymes

Abstract Third-order perturbation theory is used to obtain expressions for the energy levels of 55Mn(II)( I = 5 2 ; S = 5 2 ) in the presence of an external magnetic field with axial and rhombic distortions in the crystal field. The expressions are used to stimulate line shapes for the central ( 1 2 ↔− 1 2 ) fine structure transition in the EPR spectra for Mn(II) in complexes with enzymes.
Negative feedback effects of estrogen on luteinizing hormone-releasing hormone release occur in pubertal, but not prepubertal, ovariectomized female rhesus monkeys.

In a previous study we found that ovariectomy resulted in an increase in both LHRH release and LH release in pubertal monkeys but not in prepubertal monkeys. To determine whether this castration-induced LHRH increase is due to the removal of estrogen, in the present study, the effects of estradiol benzoate (EB, 30 micrograms/kg body wt) on in vivo LHRH release were examined using a push-pull perfusion method in prepubertal (age 15-19 months, n = 5), early pubertal (24-29 months, n = 5), and midpubertal (36-48 months, n = 5) female rhesus monkeys that were ovariectomized 3 to 5 months earlier. LHRH in 10-min perfusate fractions from the stalk-median eminence was measured from -6 to +24 h after EB injection. Circulating LH levels were also monitored over the same period at various intervals. EB decreased LH levels in early pubertal and midpubertal monkeys, whereas it did not cause any significant effects on LH release in the prepubertal monkey. EB also resulted in suppression of LHRH release in both early a...
Implicit construction of multiple eigenvalues for trees

We are generally concerned with the possible lists of multiplicities for the eigenvalues of a real symmetric matrix with a given graph. Many restrictions are known, but it is often problematic to construct a matrix with desired multiplicities, even if a matrix with such multiplicities exists. Here, we develop a technique for construction using the implicit function theorem in a certain way. We show that the technique works for a large variety of trees, give examples and determine all possible multiplicities for a large class of trees for which this was not previously known.
Water Evaporation Rates From a Model of Stratum Corneum Lipids

Water evaporation rates were measured from thin samples of a model layered structure of stratum corneum lipids with 32% water. A model with only free fatty acids present gave the lowest evaporation rates, while a model with only oleic acid gave values ∼50% higher. Using the total lipid spectrum of stratum corneum gave a structure with an evaporation rate between those mentioned above. The diffusion coefficients calculated were one to two orders of magnitude higher than those of stratum corneum, reflecting the influence of the proteinous part of the latter structure. A sample with only saturated fatty acids gave extremely high evaporation rates; in fact, they were of the same magnitude as those from an unprotected water surface.
Expression of interferon alfa signaling components in human alcoholic liver disease

Interferon alfa (IFN-alpha) is currently the only well-established therapy for viral hepatitis. However, its effectiveness is much reduced (<10%) in alcoholic patients. The mechanism underlying this resistance is not fully understood. In this study, we examined the expression of IFN-alpha signaling components and its inhibitory factors in 9 alcoholic liver disease (ALD) and 8 healthy control liver tissues. In comparison with normal control livers, expression of IFN-beta, IFN-alpha receptor 1/2, Jak1, and Tyk2 remained unchanged in ALD livers, whereas expression of IFN-alpha, signal transducer and activator of transcription factor 1 (STAT1), and p48 were up-regulated and expression of STAT2 was down-regulated. Expression of antiviral MxA a karyophilic 75 kd protein induced by IFN in mouse cells carrying the influenza virus resistance allele Mx(+) and 2'-5' oligoadenylate synthetase (OAS) proteins was not regulated, whereas expression of double-stranded RNA-activated protein kinase (PKR) was decreased by 55% in ALD livers. Three families of inhibitory factors for the JAK-STAT signaling pathway were examined in ALD livers. Members of the suppressor of cytokine signaling (SOCS) family, including SOCS 1, 2, 3, and CIS, and the protein tyrosine phosphatases, including Shp-1, Shp-2, and CD45, were not up-regulated in ALD livers, whereas the phosphorylation of and protein levels of p42/44 mitogen-activated protein kinase (p42/44MAP kinase) were increased about 3.9- and 3.2-fold in ALD livers in comparison with normal control livers, respectively. In conclusion, these findings suggest that chronic alcohol consumption down-regulates STAT2 and PKR, but up-regulates p42/44 mitogen-activated protein kinase (p42/44MAP kinase), which may cause down-regulation of IFN-alpha signaling in the liver of ALD patients.
The significance of metamorphic fluorite in the Adirondacks

Abstract Thermodynamic calculations for selected silicate-oxide-fluorite assemblages indicate that several commonly occurring fluorite-bearing assemblages are restricted to relatively narrow ƒ O 2 -ƒ F 2 fields at constant P−T. The presence of fayalite-ferrohedenbergite-fluorite-quartz ± magnetite and ferrosalite-fluorite-quartz-magnetite assemblages in orthogneisses from Au Sable Forks, Wanakena and Lake Pleasant, New York, buffered fluorine and oxygen fugacities during the granulite facies metamorphism in the Adirondack Highlands. These buffering assemblages restrict ƒ F 2 to 10−29 ± 1 bar and ƒ 0 2 to 10−16 ± 1 bar at the estimated metamorphic temperature of 1000K and pressure of 7 kbar. The assemblage biotite-magnetite-ilmenite-K-feldspar, found in the same Au Sable Forks outcrop as the fayalite-fluorite-ferrohedenbergite-quartz-magnetitie assemblage, restricts H2O fugacities to less than 103·3 bar. These fugacities limit H2 and HF fugacities to less than 101 bar for the Au Sable outcrop. The data indicate that relative to H2O, O2, H2, F2 and HF are not major species in the fluid equilibrated with Adirondack orthogneisses. The calculated F2 fugacilies are similar to the upper limits possible for plagioclase-bearing rocks and probably represent the upper ƒ F 2 limit for metamorphism in the Adirondacks and in other granulite facies terranes.
DENSE: efficient and prior knowledge-driven discovery of phenotype-associated protein functional modules

Identifying cellular subsystems that are involved in the expression of a target phenotype has been a very active research area for the past several years. In this paper, cellular subsystem refers to a group of genes (or proteins) that interact and carry out a common function in the cell. Most studies identify genes associated with a phenotype on the basis of some statistical bias, others have extended these statistical methods to analyze functional modules and biological pathways for phenotype-relatedness. However, a biologist might often have a specific question in mind while performing such analysis and most of the resulting subsystems obtained by the existing methods might be largely irrelevant to the question in hand. Arguably, it would be valuable to incorporate biologist's knowledge about the phenotype into the algorithm. This way, it is anticipated that the resulting subsytems would not only be related to the target phenotype but also contain information that the biologist is likely to be interested in. In this paper we introduce a fast and theoretically guranteed method called DENSE (Dense and ENriched Subgraph Enumeration) that can take in as input a biologist's prior knowledge as a set of query proteins and identify all the dense functional modules in a biological network that contain some part of the query vertices. The density (in terms of the number of network egdes) and the enrichment (the number of query proteins in the resulting functional module) can be manipulated via two parameters γ and μ, respectively. This algorithm has been applied to the protein functional association network of Clostridium acetobutylicum ATCC 824, a hydrogen producing, acid-tolerant organism. The algorithm was able to verify relationships known to exist in literature and also some previously unknown relationships including those with regulatory and signaling functions. Additionally, we were also able to hypothesize that some uncharacterized proteins are likely associated with the target phenotype. The DENSE code can be downloaded from http://www.freescience.org/cs/DENSE/
Self-Control Constructs Related to Measures of Dietary Intake and Physical Activity in Adolescents

Purpose To test self-regulation concepts in relation to dietary intake and physical activity patterns in adolescence, which we predicted to be influenced by components of a self-control model.
Development and performance of aluminum nitride insulating coatings for application in a lithium environment

The blanket system is one of the most important components in a fusion reactor because it has a major impact on both the economics and safety of fusion energy. Based on the requirement that an electrically insulating coating on the first-wall structural material must minimize the magnetohydrodynamic pressure drop that occurs during the flow of liquid metal in a magnetic field, aluminum nitride (AlN) is considered a candidate coating material for the lithium self-cooled blanket concept. Detailed investigations were conducted on the fabrication, metallurgical microstructure, compatibility in liquid Li, and electrical characteristics of AlN as a coating material. A nonindentation technique was used to evaluate the hardness of the coated samples in as-coated condition, after a hardening treatment, and after exposure to Li. Lithium compatibility studies were conducted in static systems by exposure of AlN-coated specimens for several time periods, at various temperatures, and in various lithium chemistries. Electrical resistance of the specimens was measured at room temperature before and after exposure to liquid Li. This paper discusses the results from ongoing activities on the development of AlN coatings.
The correlation of the backward and forward recurrence times in a renewal process

The joint complementary distribution function is used to obtain the covariance function of the backward and forward recurrence times in an ordinary renewal process for both the time dependent and the steady state cases. Hence, a closed form expression for the steady state correlation of the backward and forward recurrence times is obtained and special cases are investigated
Transposon Mediated Integration of Plasmid DNA into the Subventricular Zone of Neonatal Mice to Generate Novel Models of Glioblastoma

An urgent need exists to test the contribution of new genes to the pathogenesis and progression of human glioblastomas (GBM), the most common primary brain tumor in adults with dismal prognosis. New potential therapies are rapidly emerging from the bench and require systematic testing in experimental models which closely reproduce the salient features of the human disease. Herein we describe in detail a method to induce new models of GBM with transposon-mediated integration of plasmid DNA into cells of the subventricular zone of neonatal mice. We present a simple way to clone new transposons amenable for genomic integration using the Sleeping Beauty transposon system and illustrate how to monitor plasmid uptake and disease progression using bioluminescence, histology and immuno-histochemistry. We also describe a method to create new primary GBM cell lines. Ideally, this report will allow further dissemination of the Sleeping Beauty transposon system among brain tumor researchers, leading to an in depth understanding of GBM pathogenesis and progression and to the timely design and testing of effective therapies for patients.
NXG05-2: Fast Filter Updates for Packet Classification using TCAM

This paper addresses the problem of efficient filter updates in TCAMs. Under realistic conditions, filter updates can lead to significant performance degradation. This paper introduces an approach to using TCAMs that encodes filter priority as a TCAM field, allowing the highest priority filter to be identified with a small number of lookups, while greatly simplifying filter set management, and reducing the impact of updates on lookup throughput. Our approach supports wire-speed processing for OC-192 links using commercially available TCAM components.
A description of the type strain of Pseudomonas maltophilia1

SUMMARY A morphological and physiological description of the type strain of Pseudomonas maltophilia Hugh and Ryschenkow 1960 is presented. Photomicrographs record formalin treated and nontreated polar multitrichous flagella in stained preparations. A brief review is presented of several nomenc laturally unacceptable names which have been applied to strains of P. maltophilia.
The role of demand management in achieving supply chain agility

Purpose – The purpose of this paper is to explore the role of demand management in achieving supply chain agility (SCA) through a multi-disciplinary review of the relevant research. The systematic literature review provides the basis for formulating a conceptual framework of the relationship. Design/methodology/approach – A systematic, comprehensive review of the literature on manufacturing, marketing organizational and SCA from 1991 through 2013 was conducted. The literature on demand management is also examined to identify the various elements that contribute to SCA. Findings – Most agility frameworks take a supply-side perspective and assume that demand is known. Those that do acknowledge the role of demand fall short of offering a holistic framework that acknowledges the role of both. This paper suggests that it is simply not enough to have flexible manufacturing, distribution and procurement systems to achieve SCA. Flexibility in managing demand is also needed. Furthermore, it is the premise of this ...
Hemoptysis, history of oral ulcers, and abnormal chest radiograph in a 64-year-old man.

A 64-year-old man presents with 2 months of intermittent blood-tinged sputum and cough. He also noted mild dyspnea and subjective fevers. For the past 30 years, he has noted self-limiting clusters of oral ulcers. During these periods, he also has difficulty swallowing and was found to have esophageal ulcers. He has had one episode of nose swelling and two episodes of ear swelling and was treated with corticosteroids. Four years ago, he had bloody diarrhea, and colonoscopy revealed colonic ulcerations. He also reports an episode of iritis, intermittent nonpruritic rashes, and arthralgias.
Interaction of phospholipid vesicles with cultured mammalian cells.

To delineate some of the relationships between membrane composition and the functional states of mammalian cells, we are exploring the possibility of producing controlled modifications in the plasma membrane of cultured cells, using artificially generated lipid vesicles1–3. Although other groups have reported the use of lipid dispersions for producing cellular modifications4–10, the underlying molecular mechanisms by which these effects are produced have not been determined. We present here preliminary findings on the mechanism of interaction of chemically and physically well-defined phospholipid vesicles with cultured mammalian cells.
Interaction of HCF-1 with a cellular nuclear export factor.

HCF-1 is a cellular protein required by VP16 to activate the herpes simplex virus (HSV) immediate-early genes. VP16 is a component of the viral tegument and, after release into the cell, binds to HCF-1 and translocates to the nucleus to form a complex with the POU domain protein Oct-1 and a VP16-responsive DNA sequence. This VP16-induced complex boosts transcription of the viral immediate-early genes and initiates lytic replication. In uninfected cells, HCF-1 functions as a coactivator for the cellular transcription factors LZIP and GABP and also plays an essential role in cell proliferation. VP16 and LZIP share a tetrapeptide HCF-binding motif recognized by the β-propeller domain of HCF-1. Here we describe a new cellular HCF-1 β-propeller domain binding protein, termed HPIP, which contains a functional HCF-binding motif and a leucine-rich nuclear export sequence. We show that HPIP shuttles between the nucleus and cytoplasm in a CRM1-dependent manner and that overexpression of HPIP leads to accumulation of HCF-1 in the cytoplasm. These data suggest that HPIP regulates HCF-1 activity by modulating its subcellular localization. Furthermore, HPIP-mediated export may provide the pool of cytoplasmic HCF-1 required for import of virion-derived VP16 into the nucleus.
Dimensions of Self-Concept for Children in Kindergarten and Grades 1 and 2

This research investigated sex and grade differences in components of self-concept for 461 kindergarten, Grade 1, and Grade 2 children with the SCAMIN and IOX Self-appraisal Inventory. Sex and grade differences were found. Correlations between scales and subscales were low; it appears that these instruments measure independent constructs.
GliomaPredict: a clinically useful tool for assigning glioma patients to specific molecular subtypes

Advances in generating genome-wide gene expression data have accelerated the development of molecular-based tumor classification systems. Tools that allow the translation of such molecular classification schemas from research into clinical applications are still missing in the emerging era of personalized medicine. We developed GliomaPredict as a computational tool that allows the fast and reliable classification of glioma patients into one of six previously published stratified subtypes based on sets of extensively validated classifiers derived from hundreds of glioma transcriptomic profiles. Our tool utilizes a principle component analysis (PCA)-based approach to generate a visual representation of the analyses, quantifies the confidence of the underlying subtype assessment and presents results as a printable PDF file. GliomaPredict tool is implemented as a plugin application for the widely-used GenePattern framework. GliomaPredict provides a user-friendly, clinically applicable novel platform for instantly assigning gene expression-based subtype in patients with gliomas thereby aiding in clinical trial design and therapeutic decision-making. Implemented as a user-friendly diagnostic tool, we expect that in time GliomaPredict, and tools like it, will become routinely used in translational/clinical research and in the clinical care of patients with gliomas.
Eliciting Goals of Care in a Nursing Home

Objectives To identify enablers and barriers facing providers and staff in initiating Goals of Care (GOC) discussions with patients in the nursing home. Design Qualitative methods, one-on-one interviews. The interviews began with eliciting the participant's definition of GOC. The open-ended questions were designed to assess recent experience and satisfaction with the participant's role in the GOC discussion. Setting Nursing home. Participants We interviewed 23 nursing home staff and providers. Measurements Transcripts were qualitatively analyzed. Results Five themes emerged that were identified as barriers to discussing GOC: (1) Fear of legal ramifications; (2) Not enough education on how to have a GOC discussion; (3) Family not involved on a regular basis; (4) Time pressure; (5) Interdisciplinary team not involved. Five themes also emerged that were identified as enablers to the GOC discussion: (1) Education/experience with the GOC discussion; (2) Interdisciplinary team involved in the discussion; (3) Established trusting relationship with the patient/family/other staff; (4) Terminal diagnosis/hospice involvement; (5) Discussion occurs in-person. Conclusion A major finding of these interviews is the lack of systematic attention to GOC in the nursing home setting. Since education and experience were identified as crucial to understanding GOC, more formal education and observed practice discussing GOC is needed for all staff. The outcomes of GOC discussions should be documented in the patient record and be accessible to all staff and communicated systematically to all staff. Addressing these barriers and facilitating these enablers to the GOC discussion will improve the care of nursing home patients.
Floating metal rings (FMR), a novel high-voltage blocking technique

Floating Metal Rings (FMR), a novel high-voltage blocking technique, is proposed. Its feasibility has been demonstrated using a 600- V wide-base Bipolar Junction Transistor (BJT). The new technique supercedes the diffused guard ring approach to increasing junction breakdown. Half the semiconductor surface area is required with FMR technique compared to the diffused guard ring to achieve the same 600-V blocking voltage.
Composite structured light pattern for three-dimensional video

Based on recent discoveries, we introduce a method to project a single structured pattern onto an object and then reconstruct the three-dimensional range from the distortions in the reflected and captured image. Traditional structured light methods require several different patterns to recover the depth, without ambiguity or albedo sensitivity, and are corrupted by object movement during the projection/ capture process. Our method efficiently combines multiple patterns into a single composite pattern projection allowing for real-time implementations. Because structured light techniques require standard image capture and projection technology, unlike time of arrival techniques, they are relatively low cost.
Protecting Marine Biodiversity: A Comparison of Individual Habitat Quota (IHQs) and Marine Protected Areas

Fisheries managers in the United States are required to identify and mitigate the adverse impacts of fishing activity on essential fish habitat (EFH). There are additional concerns that the viability of noncommercial species, animals that are habitat dependent and/or are themselves constituents of fishery habitat may still be threatened. We consider a cap-and-trade system for habitat conservation, individual habitat quotas for fisheries, to achieve habitat conservation and species protection goals cost effectively. Individual quotas of habitat impact units (HIUs) would be distributed to fishers with an aggregate quota set to maintain a target habitat "stock" of EFH conservation. Using a dynamic, spatially explicit fishery simulation model we explore the efficiency and cost effectiveness of an IHQ policy versus alternative marine protected area (MPA) configurations, at reducing the risk of extinguishing a habitat dependent species of unknown spatial distribution. Our findings indicate that an IHQ policy with a conservatively established habitat target is better suited to the protection of non-target species than a rotating or fixed MPA policy.
A Qualitative Study of the Process of Facilitated Communication

Qualitative research methods were used to investigate facilitated communication as it was implemented with two sixth-grade students in a general education setting. The areas of interest in this study focused on (a) the process of facilitated communication and (b) the role or roles facilitators played in this process. Participant observations occurred in a variety of school and community settings and interviews were conducted with students, their primary facilitators, and other involved teachers and teaching assistants.The findings revealed that a wide variety of physical accommodations were used to support students during the process of facilitated communication. It appeared that each student used a unique combination of support tailored to his or her individualized needs. Additionally, findings showed that complex and detailed functions were performed by facilitators. These functions included providing physical support, decision-making, and negotiating meaning during interactions. A brief discussion of t...
Joint Optimization of Distributed Broadcast Quantization Systems for Classification

We develop a simulated annealing technique to jointly optimize a distributed quantization structure meant to maximize the asymptotic error exponent of a downstream classifier or detector. This distributed structure sequentially processes an input vector and exploits broadcasts to improve the best possible error exponents. The annealing approach is a robust technique that avoids local maxima and is easily tailored to a broadcast quantizer's structural constraints
Limited stage diffuse large B-cell lymphoma: comparative effectiveness of treatment strategies in a large cohort of elderly patients

Optimal treatment for limited stage diffuse large B-cell lymphoma (DLBCL) in the elderly is controversial. Using the Surveillance, Epidemiology and End Results-Medicare database, we compared overall survival (OS), time to second-line therapy (surrogate for recurrence) and adverse events in elderly patients diagnosed with stage I or II DLBCL in 1999-2009, who received either abbreviated rituximab, cyclophosphamide, doxorubicin, vincristine and prednisone (RCHOP) plus radiation or 6-8 cycles of RCHOP alone. Of 874 patients, 359 received abbreviated RCHOP with radiation, and 515 received a full course of RCHOP. In propensity score-adjusted analyses, OS was similar in both groups (hazard ratio [HR] 1.02, 95% confidence interval [CI] 0.76, 1.38). Abbreviated RCHOP with radiation was associated with lower risk of second-line therapy (HR 0.71, 95% CI 0.53, 0.94) and lower odds of febrile neutropenia (odds ratio [OR] 0.27, 95% CI 0.15, 0.50). While the two treatments resulted in similar survival, our data suggest that abbreviated RCHOP with radiation may be better tolerated than a full course of RCHOP.
Simulations of a Mach 3 Compression-Ramp Interaction using LES/RANS Models

Two large-eddy simulation / Reynolds-averaged Navier-Stokes (LES/RANS) models are applied to a shock / boundary interaction generated by a 20-degree compression corner. The models are designed to transition from unsteady RANS to LES as the boundary layer shifts from its logarithmic behavior to its wake-like response, but differ in that one model requires a pre-selection of a model constant for each problem, while the other computes this constant as a function of local and ensemble-averaged turbulence properties. Predictions are compared with mean-flow and second-moment experimental data obtained at Princeton University. In general, calculated mean-flow velocity, surface pressure, and surface skin friction distributions agree well with experiment, with the most noticeable discrepancy being a slight over-prediction of the level of upstream influence induced by the shock wave. Comparisons with mass-flux fluctuation intensity, Reynolds axial stress, and Reynolds shear stress profiles are also presented. These show good agreement with experimental trends relating to Reynolds-stress amplification and anisotropy modulation, particularly when assumptions used in hot-wire anemometry are employed in the computation of the Reynoldsstress profiles. The calculations also predict the existence of a low-frequency motion of the separation shock that is probably associated with the motion of the backflow region. Higherfrequency modulations of the shock front as induced by the passage of coherent, streak-like structures through the shock also appear to contribute to the measurable intermittency effects.
Status and plans for neutral weak form factors measurements

We report on a mature experimental program to measure the parity-violating asymmetry in the elastic scattering of longitudinally polarized electrons from unpolarized 1H, 2H and 4He targets. The focus is the measurement of the nucleon neutral weak form factors at intermediate four-momentum transfer (0.1 < Q 2 < 1) (GeV/c)2 which provide information about the impact of virtual strange quarks on the charge and current distributions inside nucleons. We report on recent technical progress in the design and scope of the experimental techniques. The physics implications of the published measurements are discussed and the current status and anticipated results from experiments under construction are summarized.
1.55 Å resolution X-ray crystal structure of Rv3902c from Mycobacterium tuberculosis.

The crystallographic structure of the Mycobacterium tuberculosis (TB) protein Rv3902c (176 residues; molecular mass of 19.8 kDa) was determined at 1.55 A resolution. The function of Rv3902c is unknown, although several TB genes involved in bacterial pathogenesis are expressed from the operon containing the Rv3902c gene. The unique structural fold of Rv3902c contains two domains, each consisting of antiparallel β-sheets and α-helices, creating a hand-like binding motif with a small binding pocket in the palm. Structural homology searches reveal that Rv3902c has an overall structure similar to that of the Salmonella virulence-factor chaperone InvB, with an r.m.s.d. for main-chain atoms of 2.3 A along an aligned domain.
Process synthesis of laser forming by genetic algorithm

Significant progress has been made in analyzing and predicting laser forming (LF) processes of sheet metal. Process synthesis in laser forming, on the other hand, is concerned with determination of laser scanning paths and heat condition given a target shape to form. This paper reports the development of a process synthesis methodology for laser forming of a class of shapes based on genetic algorithm (GA). The effects of GA control parameters on the synthesis process are discussed. The effects of fitness function types on achieving multiple objectives are also investigated. The synthesis process is experimentally validated through several cases under diverse conditions including one that involves close to thirty decision variables.
Quantification of Lidocaine and Several Metabolites Utilizing Chemical-Ionization Mass Spectrometry and Stable Isotope Labeling

Quantification of the suspected metabolites of lidocaine in humans was carried out using the direct insertion probe and chemical- ionization mass spectrometry. Deuterated analogs of the metabolites of lidocaine were added to serial human plasma and urine samples and were used as internal standards following oral administration of 250 mg of lidocaine hydrochloride monohydrate to two male subjects and 202 mg of lidocaine free base to one male subject. The average results after analysis of the 0–24-hr urine samples, before β-glucuronidase-sulfatase treatment, indicated the presence of seven of the possible metabolites in the following amounts (percent of administered dose based on the free base): lidocaine, 1.95; ω-ethylamino-2,6-dimethylacetanilide, 4.90; ω-amino-2,6-dimethylacetanilide, 0.88; m- and/or p-hydroxylidocaine, 0.73; m- and/or p-hydroxy-ω-ethylamino-2,6-dimethylacetanilide, 0.56; 2,6-dimethylaniline, 0.97; and 4-hydroxy-2,6-dimethylaniline, 63.5. Both N-ethyl- and N,N-diethylglycine were detected in human and Rhesus monkey urine, although quantification was not achieved.
Disfiguring burn scars and adolescent self-esteem

Abstract Although children with burn scars are reported to have positive self-concepts, social and sexual maturation can be expected to stimulate anxiety, depression and diminished self-esteem in adolescents with disfiguring scars. This study examines complex self-regard of adolescents with burn scars. The following were hypothesized: (1) adolescents with disfiguring burn scars would view themselves as less competent than unburned normative samples; (2) subjects' perceived competence would be incongruent with the importance ascribed to the domains of physical appearance and athletic competence and (3) depression/anxiety would correlate negatively with perceived competence. Subjects were 14 adolescents: 6 male and 8 female, 13–20 years old, at least 2 years post-burn injury (TBSA=39%±23%). All had scars in at least 2 of the following areas: head/face, neck, chest, hands, genitals. Each subject was administered the Harter Self Perception Profile, a standardized measure of self-competence and value in 8 domains plus a general competence measure. The subjects were also assessed for anxiety/depression by the Child Behavioral Checklist. Overall, adolescents in this sample exhibited a similar or higher degree of self-worth as compared to their peers. However, the athletic competence and physical appearance sub-domains of self-worth for the burn survivors were significantly lower as compared to the normative group. Half of the participants rated the importance of physical appearance to be higher than their level of personal competence in this area, making for distressing emotions. Mood was similar to the normative group and mood correlated significantly with self-worth.