cssi/SciSciGPT-SciSciNet huggingface dataset:
The Oregon Mental Health Referral Checklists: Concept Mapping the Mental Health Needs of Youth in the Juvenile Justice System

Thisarticlesummarizesthedevelopmentofcheckliststoidentifythementalhealthneedsof youth in the juvenile justice system. With concept mapping as its base, a 31-item checklist was developed in three parallel forms and assessed on three samples: youth in a locked correctional facility and parents and juvenile justice professionals of adjudicate youth who were sentenced to community service. The instruments appear to have acceptable to very good internal consistency and moderate to strong coefficients of equivalence. Total symptomswereassociatedwithinternalandexternalproblemsforyouth,suggestionsfrom a trusted friend that one might have a mental health problem, and various other mental healthhistoryvariables fortheyouth version. Theinstruments appearto haveacceptableto very good reliability and very good validity for the youth version; furthermore, they are useful in identifying acting-out crises and psychological crises, including harm to self, others, and property. [Brief Treatment and Crisis Intervention 5:9‐18 (2005)]
Short-term survival after surgery for epiploic foramen entrapment compared with other strangulating diseases of the small intestine in horses.

Summary Reasons for performing study: Epiploic foramen entrapment (EFE) is one of the more common causes of colic in horses, but recent reports suggest a poor prognosis after surgical treatment. Hypothesis: That EFE has a good prognosis compared with other small intestinal strangulating lesions. Methods: Surgical findings, surgical procedures and short-term outcome were recorded for 157 horses that underwent surgery for strangulating lesions of the small intestine at the University of Illinois from 1994 to 2003. Horses were assigned to 3 groups for comparison; those with EFE, strangulation by lipoma and miscellaneous strangulating lesions. A logistic regression model and Monte Carlo tests of the binomial proportions were used to examine survival rates. The Kruskal-Wallis test was used to determine differences in usage of surgical treatments. Measurements of length and viability indices were analysed using a one-way analysis of variance followed by Tukey's HSD test, and viability scores were analysed using an exact Kruskal-Wallis test. Significance was set at P<0.05. Results: Horses with EFE were significantly more likely to be discharged (95%) than those with the other conditions (P<0.05). The proportion of horses with ileal involvement was greater in horses with EFE than in the other 2 groups (P<0.05), although this did not affect outcome. The distributions of viability grades for EFE and lipoma differed significantly (P<0.05). Conclusions: The prognosis for horses that had surgery at this hospital for EFE was better than for those with the other conditions, although the greater proportion of horses with EFE with ileal involvement could influence outcome. Therefore, surgeons must consider ways of improving jejunocaecostomy and determining when bowel is viable, the latter to avoid jejunocaecostomy.
The Meta Indigenous Politico-Administrative System, Good Governance, and the Modern Republican State in Cameroon

Traditional or indigenous politico-administrative institutions, as opposed to those of western origin, appear to be regaining their once lost allure in Africa. Yet, it is not enough to simply extol...
Drought effects on water quality in the South Platte River Basin, Colorado

Twenty-three stream sites representing a range of forested, agricultural, and urban land uses were sampled in the South Platte River Basin of Colorado from July through September 2002 to characterize water quality during drought conditions. With a few exceptions, dissolved ammonia, Kjeldahl nitrogen, total phos- phorus, and dissolved orthophosphate concentrations were similar to seasonal historical levels in all land use areas during the drought. At some agricultural sites, decreased dilution of irrigation return flow may have contributed to higher concentrations of some nutrient species, increased primary productivity, and higher dis- solved oxygen concentrations. At some urban sites, decreased dilu- tion of base flow and wastewater treatment plant effluent may have contributed to higher dissolved nitrite-plus-nitrate concentrations, increased primary productivity, and higher dissolved oxygen con- centrations. Total pesticide concentrations in urban and agricultur- al areas were not consistently higher or lower during the drought. At most forested sites, decreased dilution of ground water-derived calcium bicarbonate type base flow likely led to elevated pH and specific-conductance values. Water temperatures at many of the forested sites also were higher, contributing to lower dissolved oxy- gen concentrations during the drought. (KEY TERMS: drought; water quality; agricultural hydrology; urban water management; nonpoint source pollution; wastewater.)
Accelerating Protein Sequence Search in a Heterogeneous Computing System

The "Basic Local Alignment Search Tool'' (BLAST) is arguably the most widely used computational tool in bioinformatics. However, the computational power required for routine BLAST analysis has been outstripping Moore's Law due to the exponential growth in the size of the genomic sequence databases that BLAST searches on. To address the above issue, we propose the design and optimization of the BLAST algorithm for searching protein sequences (i.e., BLASTP) in a heterogeneous computing system. The end result is a BLASTP implementation that delivers a seven-fold speedup over the sequential BLASTP for the most computationally intensive phase (i.e., hit detection and ungapped extension) on a NVIDIA Fermi C2050 GPU. In addition, when pipelining the processing on a dual-core CPU and the NVIDIA Fermi GPU, our implementation can achieve a six-fold speedup for the overall program execution.
Valve Stroking to Control Water Hammer

Equations are developed for the closing of a valve at the downstream end of a pipeline leading from a reservoir so that a maximum permitted pipe stress is not exceeded and pressures remain above their steady state values at all times. By allowing the unit of time to be the round-trip travel time of the pressure wave, the hydraulic grade line is established in the first unit of time that is linear and yields the maximum permitted pipe stress. In addition, uniform flow is established in the pipeline. The hydraulic grade line is maintained constant while the flow decelerates uniformly throughout the pipe. During the last unit of time before complete closure, the hydraulic gradeline is brought down to the level of the reservoir and the flow is brought to rest. Turbulent frictional effects are included. These equations may be applied to digital-computer solutions. Valve opening equations are also developed to avoid pressures in excess of steady state values.
Concealed carry bans and the American college campus: a law, social sciences, and policy perspective

AbstractShould individuals on American college campuses be permitted to carry concealed weapons? This issue positions second Amendment liberty guarantees against personal safety concerns and learning environment interests. Current policy prescription has yet to appropriately balance these competing demands. Accordingly, this article reviews and comments on three key dimensions of the concealed carry ban controversy. This includes a presentation of the governing case law, a recounting of the relevant social science findings, and a discussion of the societal forces and human dynamics that both inform and influence this public policy debate. We argue that these forces and dynamics constitute cultural impediments to achieving meaningful consensus-building legislation. The manuscript concludes by proposing several justice-based reformist directions with relevancies for academic researchers, political officials, and policy-makers.
Skin glomic tumors referred for local pain and cured by surgical removal.

Under the definition “glomus tumors” are often erroneously enclosed neoplasms that are absolutely unlike for origin, location, and behavior. Glomus tumors (GTs) are small but extremely painful skin tumors of mesenchymal origin. GTs derive from the neuromyoarterial glomus in adults of middle-age and are generally benign. Due to their small size, diagnosis is often difficult and patients harboring these tumors usually consult many physicians, including sometimes neurosurgeons. More familiar to neurosurgeons are neoplasms as glomus jugular, glomus vagale, and glomus tympanicum that instead all belong to the family of paragangliomas (PGs) and for this reason should not be confused with the aforementioned skin tumors. Here we present a brief review of these two different classes of tumors and also the clarification of any misunderstanding that may derive from an improper use of the terminology. In order to illustrate why skin tumors may interest neurosurgeons, we have reviewed our institutional series of outpatient surgical procedures. Differential diagnosis with other tumors that appear as cutaneous nodules is also discussed. From January 2012 to May 2015, seven patients harboring a GT (six male and one female) were treated. The age ranged from 34 to 71 years (mean, 54.1). The clinical suspect of GT, was validated by ultrasound (US) and, if necessary, by magnetic resonance imaging (MRI). All patients underwent surgery for total tumor removal. Immediate pain relief was obtained in all the patients, and no recurrences were observed during follow-up. Histology confirmed the diagnosis of GT. Subcutaneous painful nodules, originating from the glomus body, are properly called GTs. Unlikely from other tumors, as schwannomas or neurofibromas, GTs are the cause of pain that is disproportionate to their tiny size and that is not associated to neurological disturbances. Surgical treatment allows a complete regression of pain with significant patient satisfaction. Neoplasms originating from neuroepithelial cells, on the contrary, should not be defined as GTs.
Dielectric Nanodroplets: Structure, Stability, Thermodynamics, Shape Transitions and Electrocrystallization in Applied Electric Fields

The response and properties of a dielectric nanodroplet with a 10 nm diameter made of formamide placed in a uniform electric field are explored with molecular dynamics simulations and an analytic free energy formulation. Increasing fields cause the initially spherical liquid droplet to undergo gradual prolate spheroidal elongation along the field direction that culminates in a shape instability and a first-order shape transition to a slender liquid needle at a field of ∼0.50 V/nm. This transition is accompanied by enhanced reorientation of the molecular dipoles along the field direction, with the elongated droplets exhibiting a field-induced ferroelectric state, unlike the state of the droplet under field-free conditions. For larger fields, we find further gradual enhancement of the molecular dipole reorientation and the onset of a first-order electro-crystallization transition at a field of 1.4375 V/nm. This transition is portrayed by a sharp increase in the positional order parameter, a significant decr...
Organic Matter Dynamics in the Kuparuk River, a Tundra River in Alaska, USA

trans-Alaska pipeline and the Dalton Highway. The estimated streambed area of the upper Kuparuk watershed is 4.9 x 105 m2 (mainstem length x 20 m, the mean width at the lowest portion of the study reach). At the highway crossing, the Kuparuk is a 4th-order stream. At its headwaters (elevation 1250 m), the Kuparuk River drains primarily alpine communities that give way to moist tundra communities, dominated by the sedge Eriophorum vaginatum, at lower elevations. Terrestrial plant cover is minimal, with streamside patches of dwarf birches (Betula nana) and willows (Salix spp.) generally less than 1 m high. The 15-km segment of the river immediately upstream of the highway crossing is meandering, with a sinuosity (the ratio of channel length to down-valley distance, Leopold et al. 1964) of 1.5 (Kriet et al. 1992). The upper Kuparuk is relatively undisturbed by human activity. The entire watershed is underlain with permafrost, which greatly reduces deep seepage. The maximum thaw depth is less than 1 m over most of the watershed. Thaw depth beneath the riverbed has not been thoroughly investigated. The Kuparuk River is frozen solid from late September until mid to late May. Air temperatures in the region range from winter lows of -30 to -40?C to summer highs of 10 to 18?C (Selkregg 1977, Scott 1978). Mean annual water temperature for the Kuparuk is 1.7?C (J. Laundre, Marine Biological Laboratory, Woods Hole, unpublished data); during the open-water period, the mean water temperature is about 9?C. The region averages about 18 cm of precipitation annually (Selkregg 1977), although this can vary widely. Snowfall accounts for roughly half of total precipitation (Scott 1978, Kriet et al. 1992). Throughout much of the summer, the river receives continuous daylight. After its initial descent from the foothills, the upper Kuparuk has a relatively low grade (0.0313 m/m). Discharge during the 4-mo openwater period averages about 2800 L/s, but can range from 300 L/s during low-flow dry periods to 30,000 L/s in very high flows, such as spring snowmelts (Peterson et al. 1986). Discharge can increase rapidly and dramatically during even minor rains. Nutrient concentrations have been monitored
Underutilization of specimens in biobanks: an ethical as well as a practical concern?

“It’s totally false . . . that “if you build it they will come.” I thought if we build this [biobank] we’ll have people knocking on our door to use it” (Interview with a biobank director, 2011).Biobanks, organizations that acquire and store human speci-mens and associated data for future research use, may be essen-tial to realizing the promise of translational research—but not if researchers fail to come knocking on their doors. Indeed, lack of use of specimens and data by researchers may lead to biobank closure. Recent interviews and a national survey with US biobankers,
The Electoral Impact of Public Opinion on Religious Establishment

While previous work has examined the structure of public opinion on church and state, to date there has been little effort to connect public opinion on this group of issues to vote choice. I begin by hypothesizing that attitudes on religious establishment are distinct from attitudes on more often studied issues like abortion and gay marriage. Second, I argue that religious establishment meets the conditions for partisan voting: the parties and candidates have taken distinct, highly public stands on religious establishment, and the issue is highly salient among a certain segment of voters. Finally, I develop a theory that establishment attitudes should exert a greater impact among those individuals who feel that their values are threatened in contemporary society because such individuals may see religious accommodation as a means of returning to their understanding of traditional values. I test these hypotheses using data from the 2008 Cooperative Campaign Analysis Project, and I find considerable support for my argument.
Epinephrine's ketogenic effect in humans is mediated principally by lipolysis.

To quantify epinephrine's effects on acetoacetate and beta-hydroxybutyrate kinetics, we infused subjects with 0.3 and 2.5 micrograms/min epinephrine, either alone or with a concomitant somatostatin...
Influence of Different Rooting Hormone on Cutting Propagatio of Michelia martini

Taking Michelia martini's semihardwoody stems as cutting materials,it was studied that different concentrations of KIBA solution and KNAA solution influenced on them.The results showed that the rooting hormone had a significant effect on cutting;the rooting rate,average rooting number and rooting length were higher than those of CK;the rooting rate and average rooting length of the cuttings treated with IBA in different concentrations were higher than that treated with NAA in different concentrations.The rooting rate of branches treated with 3 g/L KIBA was the highest reached to 62.5% and the lengthest root was 8.9 cm.The maximum number of root was 4.3 which resulted from branches treated with 8 g/LKNAA.
The Concept of Vascular Overload in Hypertension

In order to determine more accurately hypertensive cardiovascular risk, the term vascular overload has been proposed as an alternative to the conventional use of diastolic or systolic pressure. This term encompasses both static and pulsatile forces opposing flow, that is, arteriolar resistance, large-artery stiffness, and early wave reflection. This article explores the diagnostic and therapeutic usefulness of the vascular overload concept, especially as it pertains to geriatric hypertension.
Audio File: FallingSHperf

Falling from a height holding hands sets poetry of Gary Snyder for mixed chorus (SATB) and orchestra. Its duration in performance is about seven minutes. The Boston University Symphony and Symphonic Chorus gave the premiere performance at Boston’s Symphony Hall on April 22, 2009. In a few concentrated lines Snyder presents half a conversation, and reminds us of the sharp clarity of that moment (9/11) that touched us all. Musical images crowd the mind, and I was quickly overwhelmed by a project I could not neither stop nor avoid. Once heard, this poem cannot be unheard, and the piece seized me. There are two forces here that cannot be resolved: one turbulent, confounded, uncertain, and the other calm, resolved, and clear. The latter is how the poem speaks, and at times it is almost serene. The final image, the falcon, is particularly so. Snyder frequently speaks of the “most archaic” values he holds as a poet, and as a naturalist, he knows the primordial first hand, and he allows us to draw from it as from a deep well.
Competing or Compatible Capitalisms? Exurban Sprawl and High-Value Agriculture in Southwestern Oregon

Growth in rural residential housing is broadly considered detrimental to nearby commercial agriculture. This chapter examines the historical relationship between agriculture and rural residential development in Southwestern Oregon, uncovering the contingent nature of this assumed conflict. Rather than conflicting with farming, rural population growth and the marketing of the countryside for an idealized rural lifestyle in the nineteenth and early twentieth century actually provided the needed capital and labor. Thus the passage of statewide land-use regulation in 1973 disrupted the existing land-use management regime by attempting to separate agricultural and residential uses. Local resistance to state land-use regulation reflects this historical mix of land uses. This case has implications for broader debates on the compatibility of different types of rural land uses, namely, consumptive versus extractive industries. The history of land use in Southwestern Oregon suggests that conflicts between extractive and consumptive industries are contingent on the particular uses in question.
Connected Language in Late Middle-Aged Adults at Risk for Alzheimer’s Disease

Connected language is often impaired among people with Alzheimer's disease (AD), yet little is known about when language difficulties first emerge on the path to a clinical diagnosis. The objective of this study was to determine whether individuals with psychometric (preclinical) evidence of amnestic mild cognitive impairment (pMCI) showed deficits in connected language measures. Participants were 39 pMCI and 39 cognitively healthy (CH) adults drawn from the Wisconsin Registry for Alzheimer's Prevention, who were matched for age, literacy, and sex. Participants completed a connected language task in which they described the Cookie Theft picture from the Boston Diagnostic Aphasia Examination. Language samples were analyzed across three language domains: content, syntactic complexity, and speech fluency. Paired t-tests were used to compare CH and pMCI groups on all variables, and Cohen's d effect sizes were calculated for each comparison. The CH and pMCI groups differed significantly on measures of content (e.g., CH group produced more semantic units, more unique words and had larger idea density, on average, than the pMCI group). The picture description findings are consistent with previous retrospective studies showing semantic language differences in adults with autopsy-confirmed AD. Given that these comparisons are between cognitively healthy and pMCI individuals (before a clinical MCI diagnosis), these findings may represent subtle language difficulty in spontaneous speech, and may be predictive of larger language changes over time.
José Baselga: A Vision and Roadmap for Cancer Research

As President of the American Association for Cancer Research (AACR; 2015–2016), the world's oldest, largest, and most influential cancer research scientific organization, Jose Baselga led a visionary and expansive program fostering excellence in basic, clinical, and translational research, interdisciplinary collaboration, outreach, training, and education. During his term, the announcement of the Presidential Cancer Moonshot Program energized the community and presented an unparalleled opportunity to further AACR's vision.
THE ECONOMIC PAMPHLETEER: Beyond Economic Growth

First paragraphs: We need a new vision of the future of agriculture, food systems, and communities. Most Americans seem preoccupied with a vision of economic growth — restoring it, promoting it, and sustaining it. They are unwilling to accept the fact that not only is economic growth not sustainable; it also is no longer either necessary or desirable. We need a new vision that will not compel people to "sell themselves for the means of life" but instead use their time, talents, and energy to "cultivate into fuller perfection, the art of life itself" (Keynes, 1931/1962, p. 368). The consensus of research into psychological well-being or happiness indicates that beyond some modest level of economic well-being, happiness is related far more closely to the quality of social relationships and a sense of purpose in life than with additional income or wealth (Jackson, 2011; James, 2003). For example, a 2003 article in the Guardian references a recent British Cabinet report and concluded that "despite huge increases in affluence compared with 1950, people throughout the developed world report no greater feelings of happiness" (James, 2003, para. 4). Certainly, people in some areas of the world still need economic growth. However, the so-called developing nations need not aspire to the economies needed to support American lifestyles. A 2004 review of more than 150 scholarly studies concluded that beyond per-capita incomes of around US$10,000 to US$15,000 in developing nations, there is little if any correlation between increasing wealth and overall happiness or well-being (Diener & Seligman, 2004). There is no reason to believe this relationship has change in the past decade....
Correlation of B-Lines on Ultrasonography With Interstitial Lung Disease on Chest Radiography and CT Imaging

Background We prospectively identified B-lines in patients undergoing ultrasonographic (US) examinations following liver transplantation who also had chest radiography (CXR) or chest CT imaging, or both, on the same day to determine if an association between the presence of B-lines from the thorax on US images correlates with the presence of lung abnormalities on CXR. Methods Following institutional review board (IRB) approval, patients who received liver transplants and underwent routine US examinations and chest radiography or CT imaging, or both, on the same day between January 1, 2015 through July 1, 2016 were prospectively identified. Two readers who were blinded to chest films and CT images and reports independently reviewed the US interreader agreement for the presence or absence of B-lines and performed an evaluation for the presence or absence of diffuse parenchymal lung disease (DPLD) on chest films and CT images as well as from clinical evaluation. Receiver operating characteristic (ROC) curves were constructed. Results There was good agreement between the two readers on the presence of absence of B-lines (kappa = 0.94). The area under the ROC curve for discriminating between positive DPLD and negative DPLD for both readers was 0.79 (95% CI, 0.71-0.87). Conclusions There is an association between the presence of extensive B-lines to the point of confluence and "dirty shadowing" on US examinations of the chest and associated findings on chest radiographs and CT scans of DPLD. Conversely, isolated B-lines do not always correlate with abnormalities on chest films and in fact sometimes appear to be a normal variant.
Comorbidity Profiles and Their Effect on Treatment Selection and Survival among Patients with Lung Cancer

Rationale: Prior work has shown that the comorbidity burden is high among patients with lung cancer, but patterns of comorbid conditions have not been systematically identified.Objectives: We aimed to identify distinct comorbidity profiles in a large sample of patients with lung cancer and to examine the effect of comorbidity profiles on treatment and survival.Methods: In this retrospective cohort study, we used latent class analysis to identify comorbidity profiles (or classes) in a population-based sample of 6,662 patients with bronchogenic carcinoma diagnosed between 2008 and 2013. We included specific comorbid conditions from the Charlson comorbidity index. We used Cox proportional hazards analysis to examine the effect of comorbidity class on survival.Results: The mean age of the patients was 70 years, and 50% were female, 34% were nonwhite, and 17% were never-smokers. Most patients had stage III (21%) or IV (53%) disease. Over half (51%) had at least one comorbid condition, whereas 18% had at least ...
Effects of Plume Hydrodynamics and Oxidation on the Composition of a Condensing Laser-Induced Plasma

High-temperature chemistry in laser ablation plumes leads to vapor-phase speciation, which can induce chemical fractionation during condensation. Using emission spectroscopy acquired after ablation of a SrZrO3 target, we have experimentally observed the formation of multiple molecular species (ZrO and SrO) as a function of time as the laser ablation plume evolves. Although the stable oxides SrO and ZrO2 are both refractory, we observed emission from the ZrO intermediate at earlier times than SrO. We deduced the time-scale of oxygen entrainment into the laser ablation plume using an 18O2 environment by observing the in-growth of Zr18O in the emission spectra relative to Zr16O, which was formed by reaction of Zr with 16O from the target itself. Using temporally resolved plume-imaging, we determined that ZrO formed more readily at early times, volumetrically in the plume, while SrO formed later in time, around the periphery. Using a simple temperature-dependent reaction model, we have illustrated that the fo...
A Phase II Study of Tumor Ablation in Patients with Metastatic Sarcoma Stable on Chemotherapy

Lessons learned Ablation therapy appears to be a reasonably safe and effective approach to obtain a significant treatment-free interval for a subset of patients with limited sites of metastatic disease for which systemic control can be obtained with six cycles of chemotherapy. Background Metastatic sarcoma often becomes resistant to treatment by chemotherapy. There is sometimes prolonged stable disease from active chemotherapy that provides a window of opportunity for an intervention to prolong disease-free survival. Materials and methods We performed a phase II study in patients with metastatic sarcoma who had been stable on six cycles of chemotherapy who then received ablation therapy to their residual disease. Histologies captured in this study included leiomyosarcoma, malignant peripheral nerve sheath tumor, pleiomorphic rhabdomyosarcoma, and myxoid liposarcoma. Sites ablated included lung metastases and retroperitoneal metastatic deposits. In this study, up to three lesions were ablated in any given interventional radiology session. After ablation, patients were not treated with any further therapy but were followed by surveillance imaging to determine progression-free rate (PFR). Results Although terminated early because of slow accrual, this study demonstrated a 3-month PFR of 75% for this cohort of eight patients treated with ablation performed after completion of six cycles of chemotherapy with stable disease. Median progression-free survival (PFS) was 19.74 months, and the median overall survival (OS) was not reached. Conclusion Our data are the first prospective study to suggest that ablation therapy in selected patients who are stable on chemotherapy can provide a significant progression-free interval off therapy and warrants further study in a randomized trial.
Putting Cocrystal Stoichiometry to Work: A Reactive Hydrogen-Bonded "Superassembly" Enables Nanoscale Enlargement of a Metal-Organic Rhomboid via a Solid-State Photocycloaddition.

Enlargement of a self-assembled metal–organic rhomboid is achieved via the organic solid state. The solid-state synthesis of an elongated organic ligand was achieved by a template directed [2 + 2] photodimerization in a cocrystal. Initial cocrystals obtained of resorcinol template and reactant alkene afforded a 1:2 cocrystal with the alkene in a stacked yet photostable geometry. Cocrystallization performed in the presence of excess template resulted in a 3:2 cocrystal composed of novel discrete 10-component hydrogen-bonded “superassemblies” wherein the alkenes undergo a head-to-head [2 + 2] photodimerization. Isolation and reaction of elongated photoproduct with Cu(II) ions afforded a metal–organic rhomboid of nanoscale dimensions that hosts small molecules in the solid state as guests.
Visualizing Success: Visual Schedules and Script Strategies for Teaching Play and Social Skills

Research has suggested that children with ASD often do well when treatment strategies are present in a visual domain. Additionally, the children tend to prefer many visual-based strategies. In this chapter, two visual strategies with a strong evidence base, visual activity schedules and scripts, will be discussed. The literature for each will briefly be presented, and each strategy will be explained with a “How To” procedural guide to facilitate the successful implementation of these evidence-based strategies.
Public Research/Private Alignments

As some private firms have restructured themselves as life science companies, their culture and values have become a bit more like those of a research university. Similarly, as research universities have responded to the Bayh-Doyle Act of 1982, expanding their technology transfer activities, they too have become a bit more like private companies. The fundamental science conducted at research universities stretches over very long run planning horizons. Now that a number of companies have moved forcefully into long term research and development in the field of life science, their planning horizons have become more aligned with those of research universities. With few exceptions, this alignment is enhanced by research universities having little if any expertise in capturing the market value of their discoveries. Hence, at some stage in the research and development process, research universities must turn to private companies who have greater expertise in the commercialization process. Still another layer of incentive alignment arises because of the complementarities in intellectual capital; the similarities but yet the distinct and differentiated culture and values that exist at research universities versus private companies provide the opportunity for pursuing synergies in the discovery process, especially in functional genomics. Moreover, the incentives that both organizations are prone to offer to their creative researches are another source of alignment.
A Young Man with Fever, Chills, and Abdominal Pain

A 28-year-old African-American man presented with constant, sometimes sharp, abdominal pain that was partially relieved by lying down. The pain had begun five days earlier, starting in his back and radiating to his epigastrium. He had had fever, chills, nausea, and loss of appetite for about two weeks, and constipation for four days. He had not had heartburn, bleeding, dysuria, or recent trauma.
Serological cross reactivity between polyomavirus capsids.

Multiple methods have been used to measure antibodies to polyomavirus virions. In order to have a common method for all polyomaviruses, we developed enzyme immunoassays (EIAs) using virus-like-particles (VLPs) produced in the baculovirus expression system. We tested serum samples from humans and rhesus macaques in VLP-based EIAs for the two human polyomaviruses, BK and JC virus, and two nonhuman primate polyomaviruses, simian virus 40 (SV40) and lymphotropic polyomavirus (LPV). Rhesus sera exhibited low level reactivity to BK and JC, and approximately 10 and 15% of human sera showed low level reactivity to SV40 and LPV, respectively. Competitive inhibition assays with VLP protein demonstrated that the reactivity of rhesus sera against BK and JC VLPs was blocked by both SV40 and the respective human polyomavirus, indicating that the BK and JC assays were detected cross-reacting antibodies Similarly, the reactivity of the majority of human sera to SV40 was blocked by both SV40 and BK or JC, demonstrating that the SV40 reactivity of human sera is largely due to cross reacting BK and JC antibodies. In contrast, the reactivity of human sera to LPV VLPs was blocked by LPV but not by BK or JC, providing serological evidence for an unknown human polyomavirus related to LPV. SV40 and LPV VLP-based EIAs and competitive inhibition assays with heterologous VLPs provide tools for seroepidemiological studies of possible SV40 and LPV-like infections of humans.
Progesterone receptor integrates the effects of mutated MED12 and altered DNA methylation to stimulate RANKL expression and stem cell proliferation in uterine leiomyoma.

Progesterone and its receptor, PR, are essential for uterine leiomyoma (LM, a.k.a., fibroid) tumorigenesis, but the underlying cellular and molecular mechanisms remain unclear. The receptor activator of NF-κB (RANKL) was recently identified as a novel progesterone/PR-responsive gene that plays an important role in promoting LM growth. Here, we used RANKL as a representative gene to investigate how steroid hormone, genetic, and epigenetic signals are integrated to regulate LM stem cell (LSC) function. We demonstrated that RANKL specifically upregulates LSC proliferation through activation of Cyclin D1. RANKL gene transcription was robustly induced by the progesterone agonist R5020, leading to a dramatically higher RANKL expression in LM compared to adjacent myometrial (MM) tissue. MethylCap-Seq revealed a differentially methylated region (DMR) adjacent to the distal PR-binding site (PRBS) 87 kb upstream of the RANKL transcription start site. Hypermethylation of the DMR inhibited recruitment of PR to the adjacent PRBS. Luciferase assays indicated that the DMR and distal PRBS constitute a novel RANKL distal regulatory element that actively regulates RANKL expression. Furthermore, MED12 physically interacts with PR in LM tissue. The interaction between MED12 and PR, binding of PR and MED12 to PRBS, and RANKL gene expression are significantly higher in LM containing a distinct MED12 mutation (G44D) than in LM with wild-type MED12. In summary, our findings suggest that DNA methylation and MED12 mutation together constitute a complex regulatory network that affects progesterone/PR-mediated RANKL gene expression, with an important role in activating stem cell proliferation and fibroid tumor development.
Effect of Vasoconstrictor Agents on the Duration of Action of Intrathecal Tetracaine, Bupivacaine and Lidocaine in the Dog

Both epinephrine and phenylephrine are capable of prolonging the duration of anesthesia when added to solutions of tetracaine intended for intrathecal use. Conflicting data exist concerning the relative efficacy of vasoconstrictor agents added to lidocaine and bupivacaine solutions intended for intrathecal use. The present investigation was initiated to study the comparative efficacy of epinephrine and phenylephrine in combination with tetracaine, lidocaine, and bupivacaine employing a model for spinal anesthesia in the dog. The results indicate that epinephrine and phenylephrine are capable of significantly prolonging the duration of motor blockade induced by tetracaine in the dog. When compared to plain solutions, no significant prolongation of motor blockade was observed following intrathecal administration of either lidocaine or bupivacaine with epinephrine and phenylephrine.
Cross-Sex Best Friendships and the Experience and Expression of Jealousy within Romantic Relationships

This study investigated cross-sex best friendships in the experience and expression of jealousy within romantic relationships. Survey data (N = 346) revealed engaged-to-be-married individuals, compared to single, dating and married individuals, have the most negative attitudes regarding cross-sex best friendships. Results further indicated preventive jealousy experience is a predictor of rival-focused jealousy expression, and reactive jealousy experience is a predictor of both constructive and destructive jealousy expressions. Findings also suggest attitudes toward cross-sex best friendships can mediate the relationship between how jealousy is experienced and expressed in relation to reactive jealousy experience and destructive jealousy expression. Implications are discussed regarding how cross-sex best friendships can adversely affect romantic relationships.
A Markovian Method for Predicting Trust Behavior in Human-Agent Interaction

Trust calibration is critical to the success of human-agent interaction (HAI). However, individual differences are ubiquitous in people's trust relationships with autonomous systems. To assist its heterogeneous human teammates calibrate their trust in it, an agent must first dynamically model them as individuals, rather than communicating with them all in the same manner. It can then generate expectations of its teammates' behavior and optimize its own communication based on the current state of the trust relationship it has with them. In this work, we examine how an agent can generate accurate expectations given observations of only the teammate's trust-related behaviors (e.g., did the person follow or ignore its advice?). In addition to this limited input, we also seek a specific output: accurately predicting its human teammate's future trust behavior (e.g., will the person follow or ignore my next suggestion?). In this investigation, we construct a model capable of generating such expectations using data gathered in a human-subject study of behavior in a simulated human-robot interaction (HRI) scenario. We first analyze the ability of measures from a pre-survey on trust-related traits to accurately predict subsequent trust behaviors. However, as the interaction progresses, this effect is dwarfed by the direct experience. We therefore analyze the ability of sequences of prior behavior by the teammate to accurately predict subsequent trust behaviors. Such behavioral sequences have shown to be indicative of the subjective beliefs of other teammates, and we show here that they have a predictive power as well.
A Comparison of Facial Muscle Activation for Vocalists and Instrumentalists

The purpose of this study was to compare the muscle activation of singers and instrumentalists while performing simple vocal exercises. Volunteer participants (N = 28) were undergraduate music majo...
Iterative Spectral Mollification and Conjugation for Successive Edge Detection

Fourier concentration method is a well-established method for finding edges given a set of truncated Fourier data. However, it is hard to distinguish weak jumps from the Gibbs oscillations with the method unless the concentration is highly refined locally. In this note, we show that it is possible to find all edges whether strong or weak by using the method iteratively. The iterative method first finds strong edges followed by an iterative procedure in which previously found edges are smoothed by local adaptive mollifier. The iterative method is advantageous when the ratio of the largest to smallest jump magnitudes is significantly large.
Fermion Parquet: The Approximations

The full parquet approach to many-body theory represents a self-consistent summation of Feynman diagrams for the two-body Green’s function, G 2, in terms of the bare interaction, V, and the one-body Green’s function, G. The parquet equations sum the reducible diagrams for G 2 which are generated from any initial set of irreducible diagrams. The full one-body G which is used in the construction process is obtained from the proper self-energy ∑ and the non-interacting Green’s function with the usual Dyson equation. One level of self-consistency is attained by constructing the ∑ from the G 2. The ∑ is obtained by closing off the G 2 with a V as shown in fig. 1.
Apoptotic Neuron-Derived Histone Amyloid Fibrils Induce α-Synuclein Aggregation

Cell-to-cell transfer of α-synuclein (αS) is increasingly thought to play an important role in propagation of αS pathology, but mechanisms responsible for formation of initial αS seeds and factors facilitating their propagation remain unclear. We previously demonstrated that αS aggregates are formed rapidly in apoptotic neurons and that interaction between cytoplasmic αS and proaggregant nuclear factors generates seed-competent αS. We also provided initial evidence that histones have proaggregant properties. Since histones are released from cells undergoing apoptosis or cell stress, we hypothesized that internalization of histones into αS expressing cells could lead to intracellular αS aggregation. Here using mCherry-tagged histone, we show that nuclear extracts from apoptotic cells can induce intracellular αS inclusions after uptake into susceptible cells, while extracts from non-apoptotic cells did not. We also demonstrate that nuclear extracts from apoptotic cells contained histone-immunoreactive amyloid fibrils. Moreover, recombinant histone-derived amyloid fibrils are able to induce αS aggregation in cellular and animal models. Induction of αS aggregation by histone amyloid fibrils is associated with endocytosis-mediated rupture of lysosomes, and this effect can be enhanced in cells with chemically induced lysosomal membrane defects. These studies provide initial descriptions of the contribution of histone amyloid fibrils to αS aggregation.
The Transition Into Professorship: Beyond the Three-Phase Approach to Socialization

This article outlines a brief review of literature of occupational socialization theory. Specific to physical educators, occupational socialization theory examines the ways individuals are recruited into, prepared for, and socialized in the profession. It represents a dialectical perspective on socialization, acknowledging that educators are shaped by the institutions that seek to socialize them, but that they can resist the influence of this socialization. This article also discusses the key issues affecting physical education teacher education (PETE) doctoral programs and the means by which PETE doctoral students are socialized into the role of university educators.Subscribe to TPE
NON-ST-Segment Elevation Myocardial Infarction Associated with Inadvertent Thyroid Hormone Overdose

Thyroid hormone has a major role in cardiovascular function and cardiac hemodynamics. A slight change in thyroid affects ventricular function, serum cholesterol levels, increases the risk of coronary artery disease as well as cardiovascular mortality. In this report, we present a 62-year-old female with history significant for ischemic heart disease who was admitted for acute coronary syndrome (ACS) with persistent tachycardia, requiring urgent cardiac catheterization. Complete cardiac workup revealed that the patient had most likely suffered from vasospastic angina secondary to inadvertent overdose of her prescribed levothyroxine. This report emphasizes the significant cardiac complications caused by a deluged hyperadrenergic state secondary to overt hyperthyroidism. We conclude that thyrotoxicosis is a significant risk factor for cardiovascular disease and should be considered as a cause of life-threatening myocardial ischemia, especially in patients with known ischemic heart disease and thyroid disorders.
General Approach to Chronic Pain

Chronic pain affects more than 100 million adults in the United States and is more common in women than men. The perception of chronic pain in individual patients is complex, so the evaluation and treatment need to be comprehensive and individualized. Patients with chronic pain should be evaluated with a thorough clinical history including a functional evaluation, a thorough physical exam, and additional testing only when indicated. Chronic pain is often treated more successfully if multiple approaches are used, including medications, physical therapy, behavioral therapy, complementary or alternative medicine, interventional techniques, and surgical approaches. Many classes of medication can be used to treat chronic pain including non-opioid analgesics, topical agents, tricyclic antidepressants (TCAs), serotonin and norepinephrine reuptake inhibitors (SNRIs), and anticonvulsants. Non-pharmacologic and non-opioid pharmacologic therapies should be used preferentially over opioid therapy. The patient-provider relationship is key in the treatment of chronic pain—it is important to set realistic expectations and practice shared decision-making.
Does Physical Activity Level Influence Total Hip Arthroplasty Expectations, Satisfaction, and Outcomes?

Abstract Background Total hip arthroplasty (THA) patients expect pain relief and functional improvement, including return to physical activity. Our objective was to determine the impact of patients' physical activity level on preoperative expectations and postoperative satisfaction and clinical outcomes in patients undergoing THA. Methods Using an institutional registry of patients undergoing THA between 2007 and 2012, we retrospectively identified patients who underwent unilateral primary THA for osteoarthritis and completed a preoperative Lower Extremity Activity Scale, Hospital for Special Surgery Hip Replacement Expectations Survey, and Hip disability and Osteoarthritis Outcome Score in addition to two-year HOOS and satisfaction evaluations. Active patients (n = 1053) were matched to inactive patients (n = 1053) by age, sex, body mass index, and comorbidities. The cohorts were compared with regard to the association of expectations with Hip disability and Osteoarthritis Outcome Score and satisfaction, the change in Lower Extremity Activity Scale level from baseline to 2 years, complications, and revision surgical procedures. Results Significantly more active patients (74%) expected to be “back to normal” regarding ability to exercise and participate in sports compared with inactive patients (64%, P Conclusion At 2 years after THA, active and inactive patients were similarly satisfied and achieved comparable outcomes. Inactive patients showed a greater improvement in physical activity level from preoperative baseline than active patients. Complications and revision rates were similar. Level of Evidence III.
Cracking Public Space Open: Design for Public Librarians

Public libraries in the U.S. and around the world are rapidly changing due to expanding technological and social needs of their communities. Furthermore, in recent years, public spaces, including libraries, have faced budgetary and other pressures, putting a strain on the resources available to librarians. As such, public libraries are a compelling cite for uncovering socio-technical entanglements between government services, technology use, public space, and civic participation. In this paper, we report on a qualitative study of librarians in a U.S. urban public library system undergoing substantial renovations and transformations. We frame the work of librarians as a range of infrastructuring practices, which help uncover insights about the socio-material and political conditions of public service in libraries. Using the metaphor of cracking public space open, we contribute a set of design provocations to support an increasingly complex work of public librarians.