cssi/SciSciGPT-SciSciNet huggingface dataset:
Lateralized cognitive dysfunction and psychotic symptoms in schizophrenia

Our understanding of hemispheric asymmetries in schizophrenia can be attributed to extensive neuropsychological and neuroimaging research on this topic; however, it has yet to be determined whether lateralized cognitive dysfunction represents a single core trait in schizophrenia or whether the lateralized impairments are domain specific. To test whether lateralized deficits are core features in schizophrenia we examined performance across a wide range of lateralized cognitive domains including attention, fluency, recognition memory, perception, and arousal. We also examined the relationship between lateralized impairments and psychotic and affective symptoms to determine whether abnormal hemispheric asymmetries were possibly state-related. The sample consisted of 43 subjects with schizophrenia and 66 normal healthy comparison subjects without psychiatric illness. Schizophrenia subjects exhibited abnormal right hemisphere performance on a test of recognition memory and abnormal left hemisphere performance on a measure of arousal. These findings suggest that lateralized cognitive disturbances in schizophrenia do not represent a single core lateralized deficit. Regarding the symptom analyses, severity of positive symptoms was related to right hemisphere cognitive impairment (including fluency and recognition memory), whereas severity of negative symptoms was related to left hemisphere cognitive impairment (including fluency). Overall, our findings suggest that lateralized dysfunction can occur in both hemispheres in schizophrenia, and that the positive psychotic symptoms may relate more to right hemisphere impairment, whereas negative psychotic symptoms may related more to left hemisphere impairment.
A 0.25-micron Smart Power Technology optimized for wireless and consumer applications

In this paper simultaneous optimization of 4.5-5.5V N and PMOS devices, 20-30V NLDMOS and NPN and PNP bipolar devices in a 0.25 /spl mu/m Smart Power Technology for portable wireless and consumer applications is discussed. With the addition of two designated wells, ultra-low resistance N and PMOS devices with good analog characteristics, best in class 30V NLDMOS as well as integrated high performance NPN and PNP bipolar devices is demonstrated.
Modeling and Forecasting Aurora

Modeling the physical processes needed for forecasting space-weather events requires multiscale modeling. This article discusses several models researchers use to treat the various auroral processes that influence space weather.
entrigue: re-picturing the home

Despite the volume of work that has been done on awareness displays, little has been articulated about the ways in which people achieve, understand and maintain awareness in their everyday routines. We reexamine awareness through the design of entrigue, a simple, lightweight photo display that captures the comings and goings in a home. Initial experiences of the system in use indicate that it offers a way of defamiliarizing a space, allowing a household to playfully re-experience the home and the ways in which they moved through it. By drawing attention to the idiosyncratic ways in which people make sense of cues and routines in the home, our results suggest that awareness incorporates a sense of how one engages with the environment, and highlights the notion of intrapersonal awareness as an awareness one can explore of oneself in and through this engagement.
Efficient simulation for large deviation probabilities of sums of heavy-tailed increments

Let (Xn:n ges 0) be a sequence of iid rv's with mean zero and finite variance. We describe an efficient state-dependent importance sampling algorithm for estimating the tail of Sn = X1 + ... + Xn in a large deviations framework as n - infin. Our algorithm can be shown to be strongly efficient basically throughout the whole large deviations region as n - infin (in particular, for probabilities of the form P (Sn > kn) as k > 0). The techniques combine results of the theory of large deviations for sums of regularly varying distributions and the basic ideas can be applied to other rare-event simulation problems involving both light and heavy-tailed features
Water-driven ligations using cyclic amino squarates: a class of useful SN1-like reactions.

We report a class of water-soluble and -stable cyclic amino squarates that ligate with cysteine or lysine residues without side-products in an entirely aqueous environment. The ligations include addition–elimination reactions that are promoted by water in a way similar to SN1 reactions. The structural versatility of the reactants allows the potential recognition of selected amino acid residues on proteins.
Thermal actuation of high frequency micromechanical resonators

This paper demonstrates the possibility of thermally actuating high-frequency micromechanical resonators. A single-mask fabrication process was used to fabricate high frequency single crystal silicon resonators on SOI substrates. The resonators where operated in a one-port configuration with parts of the resonator structure performing both thermal actuation and piezo-resistive sensing. Quality factors as high as 63,800 and resonance frequencies as high as 5.1MHz have been demonstrated. It is shown theoretically and experimentally that thermal actuation is a more suitable approach for higher frequency resonators with dimensions in the lower microns and nanometer range.
The Lost Drum: The Myth of Sexuality in Papua New Guinea and Beyond

The Lost Drum: The Myth of Sexuality in Papua New Guinea and Beyond. James F. Weiner. Madison: University of Wisconsin, 1995. 199 pp.
Accounting Research Manager

Accounting Research Manager (ARM) is a database containing all of the primary source materials for professionals engaged in financial reporting. Supplementing this content is a rich repository of e...
Film Records Management

records management is still in its infancy. The National Archives years ago established the record character of photographic materials, developed record copy concepts, made valuable studies on the storage and flammability of nitrate film, and explored the field of finding aids. Until recently, however, the influence of the National Archives was not felt to any large degree within those units of Federal or State governments that produce film records. Such units are usually part of technical organizations that are more interested in the current use of records than in their historical evaluation or permanent preservation. But with the recent recognition of the tangible and intangible benefits of records management, archival concepts are being adopted and procedures for the handling of film records are being developed by such organizations as the United States Air Force Motion Picture Film Depository at Wright-Patterson Air Force Base. As such agencies meet and solve the problems posed by the centralization, evaluation, and handling of film records, data for the guidance of other organizations will become available. Some scattered data on technical problems already can be found in special journals, such as that of the Society of Motion Picture and Television Engineers. Much information is being1 collected, too, by new groups that serve as focal points for the centralization of knowledge about the scope of pictorial holdings. Among the groups active in this field are the Picture Division of the Special Libraries Association, which publishes Picturescope; the Graphic History Society of America, which publishes Eye to Eye; the George Eastman House, which publishes Image; and the Society of American Archivists Committee on Audio-Visual Records, which was established in 1953. While these organizations have not yet reached the point of recommending what can or should be done to preserve
Aquatic Bloom

"Aquatic Bloom" is about the playful interactions of a mechanical fish and a hermit crab with a flower.
Abstract 5499: A descriptive epidemiological study of lobular carcinoma of the breast and the effects of normal lobular regression at menopause

Background: Lobular carcinoma (LC) is a distinctive neoplasm originating in the milk producing glands and constituting about 12% of all breast cancer cases. LC differs from the more common invasive ductal carcinoma (IDC) by morphology and biology. We report the results of a descriptive epidemiological study of LC and a comparison of the pathogenesis of lobular and ductal carcinoma of the breast. Methods: A total of 86,846 cases of invasive LC (ILC) from women, aged 20 to 85, were obtained from NCI9s SEER Program for the years 1973-2008 in the United States. There were 20,512 cases of LC in-situ (LCIS) and 66,634 cases of ILC. For comparison, 692,201 cases of IDC and 61,569 cases of ductal carcinoma in situ (DCIS) were collected. The analysis compared trends, age specific rates, log-log plots, age frequencies and relative survival rates. Results: From 1973-2008, the age-adjusted rate of LC progressively increased from 5.8 to 16.4/ 100,000 women. In an age frequency analysis of age versus rate, LCIS increased to 0.22/ 100,000 women at age 50, and then declined to 0.02/100,000 women at age 80. ILC increased to 0.11/100,000 women at age 50, and then plateaued after menopause but did not decline. Log-log plots revealed parallel curves between ILC and IDC in both pre-menopausal and post-menopausal age groups. At age 50, the age specific rate of LCIS increased to 11.3/100,000 women then progressively decreased. In contrast, the age specific rate of DCIS was 22.1/100,000 women at age 50 and continued to increase after menopause. Conclusions: At menopause, the incidence of LCIS decreases as a result of lobular involution of the breast. In contrast, DCIS continues to increase. ILC does not decline but plateaus suggesting that the initiation of ILC occurs before menopause, but the tumor becomes clinically apparent only after menopause. Although morphologically different, parallel log-log plots of age specific rates and age frequency analysis suggest a similar pathogenesis for IDC and ILC even though epidemiological patterns are different. Citation Format: {Authors}. {Abstract title} [abstract]. In: Proceedings of the 103rd Annual Meeting of the American Association for Cancer Research; 2012 Mar 31-Apr 4; Chicago, IL. Philadelphia (PA): AACR; Cancer Res 2012;72(8 Suppl):Abstract nr 5499. doi:1538-7445.AM2012-5499
Beyond the “Ecological Indian”: Environmental Politics and Traditional Ecological Knowledge in Modern North America

AbstractThe idea of the ecological Indian dates back to at least the early modern period in Europe and initial colonial encounters between Europeans and Native North Americans. In the minds of Euro...
Alucone Alloys with Tunable Properties Using Alucone Molecular Layer Deposition and Al2O3 Atomic Layer Deposition

Ultrathin and conformal hybrid organic–inorganic thin films can be deposited by molecular layer deposition (MLD) techniques. By combining the hybrid organic–inorganic MLD process with an inorganic ...
Influences of Cultural Conditions on Polyphenol Formation and Growth of Amacha Cells (Hydrangea macrophylla Seringe var. Thunbergii Makino) and Changes of Polyphenol Contents in Leaves of Amacha Plant during Growth

Suitable cultural conditions for polyphenol formation were examined in the amacha cultured cells. Factors tested included; inoculum size, sucrose concentration, various carbon sources, extract (malt extract and yeast extract), kinetin, auxins, initial pH, light exposure and phosphate concentration. Sucrose concentration had marked effects on cell growth and polyphenol production, and phosphate concentration was significant in polyphenol formation, although other investigated factors had no effects on polyphenol productivity. The time course of polyphenol accumulation in cultured cells showed that polyphenol content decreased at the lag and early-exponential phases of growth, and increased remarkably till the stationary phase. Cells at the stationary phase did not accumulate polyphenol and even lost these polyphenols to the external medium as the cells reached the declining phase. Large scale culture of amacha cells was carried out using a 15 liter jar fermentor. Investigations on polyphenol content change...
Phylogeographic concordance factors quantify phylogeographic congruence among co‐distributed species in the Sarracenia alata pitcher plant system

Comparative phylogeographic investigations have identified congruent phylogeographic breaks in co-distributed species in nearly every region of the world. The qualitative assessments of phylogeographic patterns traditionally used to identify such breaks, however, are limited because they rely on identifying monophyletic groups across species and do not account for coalescent stochasticity. Only long-standing phylogeographic breaks are likely to be obvious; many species could have had a concerted response to more recent landscape events, yet possess subtle signs of phylogeographic congruence because ancestral polymorphism has not completely sorted. Here, we introduce Phylogeographic Concordance Factors (PCFs), a novel method for quantifying phylogeographic congruence across species. We apply this method to the Sarracenia alata pitcher plant system, a carnivorous plant with a diverse array of commensal organisms. We explore whether a group of ecologically associated arthropods have co-diversified with the host pitcher plant, and identify if there is a positive correlation between ecological interaction and PCFs. Results demonstrate that multiple arthropods share congruent phylogeographic breaks with S. alata, and provide evidence that the level of ecological association can be used to predict the degree of similarity in the phylogeographic pattern. This study outlines an approach for quantifying phylogeographic congruence, a central concept in biogeographic research.
Impact of Edible Fungi Development and Utilization on Income of Workers in Forest Regions

In 2013,this paper adopted the method of questionnaire and in-home interviews to make an investigation on the basic characteristics,income and source,land management status,and edible fungus related situation in Songhuajiang Forest Region; through the establishment of regression model,it analyzed the effects of related variables on the forest area hill worker household income from various angles. The results showed that the edible fungus production,management area had the positive significant impact on income,regression coefficients were 0. 87 and 0. 73; Family labor quantity and attending technical training or not had positive significant impact on income,regression coefficients were 0. 17,and 0. 19; the input of labor time had general impact on the income,the regression coefficient was 0. 11; other variables effects on the economic were not significant. And it put forward the edible fungus exploitation and utilization countermeasures and suggestions for promoting forest area worker residents' income.
Clinical analysis of SIADH after chemotherapy in childhood ALL

Objective To analyze the clinical data and explore the characteristics of SIADH after chemotherapy in childhood ALL,and then to improve the understanding,diagnosis and treatment of this complication. Methods Clinical data was collected and analyzed in patients with SIADH after chemotherapy during January 2011 to June 2014 in hematology and oncology department of Shenzhen Children's Hospita1. Results There were 103 children with ALL who received regular chemotherapy,in which 13 cases occurred SIADH,the incidence was 12. 6%. The ratio of male to female was 2. 25: 1.Their median age was 5 years( range: 1-15). There were 23 episodes of hyponatremia in the 13 SIADH cases,in which 5 patients( 38. 5%) occurred once while 8 patients( 61. 5%) occurred more than one time. Clinical symptoms appeared in 11 episodes( 47. 8%),while 12 episodes( 52. 2%) of hyponatremia showed asymptomatic. In all episodes,the average serum sodium level was 127. 21 ± 7. 22 mmol / L. Ten episodes of SIADH were observed in the stage of VDLD remission induction,5 episodes in the stage of CAM consolidation,1 episode in the stage of Block 1 and Block 2 intensive treatment and 6 episodes in the stage of VALD re-induction. The average duration of hyponatremia was 5. 73 ± 4. 32 days( range: 1-19) in these 23 episodes. SIADH probably caused by dexamethasone,vincristine,L-asparaginase,daunomycin,doxorubicin,cyclophosphamide,methotrexate,ifosfamide and vindesine. Conclusions SIADH secondary to chemotherapy in childhood ALL is not rare,but the prognosis is favorable through close observation and fluid restriction when necessary.
Software Architecture Rationale Capture through Intelligent Argumentation

A growing model for software architecture defines it as a set of principal design decisions which describe the system. These design decisions need to be made by resolving design issues in a collaborative environment that helps software architects to design the architecture of a system. The architecture design decisions are usually made based on experiences since there aren’t defined methods and models for architecture design. Each design decision yields a set of outcomes which impacts both the system architecture and the final product. As software product systems tend to be large in size, one need to understand the rationale behind decision of each architectural element. This is to justify the system’s design and to avoid critical architectural problems. Often during these design decision making process the rationale is not fully captured. This paper identifies and addresses the above mentioned research challenge. It presents a method for software stakeholders to use intelligent argumentation system for collaborative rationale capture. The argumentation will be recorded in an online system to document the rationale behind the design decisions resulting in product architecture. Finally, the proposed method is evaluated using a case study. It demonstrates feasibility of capturing software architecture rationale using intelligent on-line argumentation.
Interrelationships between plasma hormone levels and the content of total protein, gonadotropins and steroid hormones in antral fluids of women undergoing in vitro fertilization.

Follicle development was induced in 41 women with follicle-stimulating hormone (FSH) and human menopausal gonadotropin. Blood samples were drawn and follicular fluids (FF) were aspirated when two or more follicles attained diameters of 15 to 17 mm. Levels of estradiol (E 2 ), progesterone (P), FSH, and luteinizing hormone (LH) were determined in samples by radioimmunoassay, and relationships between the measured parameters in antral fluids and in serum were examined by least-squares linear regression analysis. Levels of LH in serum correlated with LH and FSH levels in FF ( P 2 , and total protein in FF ( P 2 levels in serum were predictive of E 2 levels in FF only, and levels of P in serum were directly correlated with P levels in FF ( P
New Ways to Think about Business Education for Emerging Markets

The three sections of this book have explored the interrelated themes of regional differences, adaptations to management education programs and developing trends that open new possibilities for management edu- cation in emerging markets. This chapter suggests a systematic evalua- tion and structuring of management education to ensure that programs are designed appropriately for emerging markets.
The Team Approach in the Management of Congenital and Acquired Deformities

This article provides a summary of practices and guidelines for the design and methods used to form interdisciplinary medical teams. Education and organizational resources are discussed with regard to children with congenital anomalies, specifically craniofacial and cleft lip and palate deformities. The team format is recommended to maximize efficiencies and assure a continuum of care in the evolving managed care environment.
Energy and Momentum Balance

The outwards increase of temperature in the chromosphere and corona is associated with dissipation of mechanical energy presumably carried upwards from the photosphere as wave motion. This mechanical energy, dissipated as heat, ultimately finds its way out of the Sun primarily in the form of radiation. A small percentage of the energy is carried outwards by conduction and convection in the solar wind. This is not to say, however, that convection and conduction are not locally important within the atmosphere. The sharp increases in temperature between temperature plateaus suggest that thermal conduction is important in these regions. In the case of the transition region between the chromosphere and corona where we have been able to form an estimate of the conductive energy flux we find that the flux indeed is large. The average value of T 5/2 dT/dh for the transition region corresponds to a conductive flux of F c ≈ 6 x 105 erg cm−2 s−1 in regions of vertical magnetic field and in a spherically symmetric atmosphere. Radiation flux from the corona amounts to 1−3 x 105 erg cm−2 s−1 depending on the level of solar activity. Similarly, the radiation flux from the upper chromosphere, which is almost entirely in the Lyman-α line, amounts to 2−4 x 105 erg cm−2 s−1, again depending on the level of solar activity. The radiation losses from the upper chromosphere and corona occur in emission lines that are produced by collisional excitations. As such, they represent a direct loss of energy from the thermal reservoir and must, therefore, be balanced by an equivalent energy input. As we noted earlier, the basic heat input comes from the mechanical energy carried upwards. It seems clear, however, that thermal conduction through the transition region may represent a strong energy drain on the inner corona and may provide a strong source of energy in the upper chromosphere. The actual value of the conductive flux is uncertain because of the complex magnetic field structure in the transition region.
The Deccan Wars

With the exception of the Tamil regions of the Golconda and Bijapur Karnatak, but recently conquered in the 1640s, the western Deccan of the Marathas and the eastern Deccan of the Telugus had long been accustomed to Indo-Muslim rule. Mughal annexation and administration of Golconda proceeded smoothly in the years immediately after the conquest. Before conquest the ongoing alliance between the Bhonsla rulers and Golconda had ensured that the eastern Deccan was free from Maratha raids. Throughout the Jinji siege, Maratha commanders alternated between expeditions to the south to assist Rajaram and spells of campaigning in the western Deccan. Rajaram's Jats outmaneuvered the local imperial forces and occupied Sikandra where they succeeded in looting Akbar's tomb. Aurangzeb's long absence from the North Indian heartland of the empire and his obsession with the endless Deccan war strained imperial institutions.
Development and testing of corona array and nanosecond pulsed power system for electroporation

Corona arrays for electroporation were developed by electrode discharge machining (EDM) of stainless steel sheets, to create an electrode area of ∼5 cm2 with 475 to 2448 tips depending on their spacing. There is also a gas inlet and mixing area in between each sheet to allow gas to flow between them. Initial testing was done using a fast ionization dynistor (FID) power supply, which showed good uniformity across the tips for a variety of gas flows (air, N2, Ar, and He) and substrates (glass, metal, and porcine skin). Optical emission spectroscopy (OES) of the plasma showed OH formation with argon gas flows, NO formation with N2 gas flows, and OH, NO, O, H, and N2+ formation with helium gas flow. Air had the highest vibrational temperature, suggesting the highest E/n of the gasses tested, thus it is the most desirable for the electroporation application. A nanosecond pulsing circuit, capable of delivering 2–40 kV pulses with FWHM of >20 ns by using two spark gaps as switches, was developed as a simpler and more controllable system to compare to the FID power supply. Overall both power supplies created corona discharges fairly uniform across all of the tips. The plasma generated using the nanosecond pulsing circuit was non-equilibrium for all substrates (glass, metal, and porcine skin) with average temperatures Trot=318±38 K and Tvib=4101±755 K. The corona discharge from the nanosecond pulsing circuit was imaged using an ICCD camera, and noted to travel at ∼3×106 m/s, indicating a fast ionization wave.
Mixed-Income Housing in the HUD Multifamily Stock

This article uses a new national data set to test hypotheses about mixed-income housing, here defined as housing that: includes families with relatively higher incomes; is partly subsidized and partly market-rate; or has a predominance of families not dependent on welfare. We conclude that mixed-income housing usually is found in low-poverty neighborhoods. It is feasible in high-poverty neighborhoods only when there are special housing market conditions, such as immigrants who are willing to use assisted housing in poor neighborhoods as a starting point. In general, mixed-income housing does not require special rent incentives such as ceiling rents. Housing that is diverse in racial and ethical terms is as likely to have a broad range of incomes as is housing in which one group predominates.
The Artist as Environmentalist: Ansel Adams, Policy Entrepreneurship, and the Growth of Environmentalism

The role of the policy entrepreneur in the policy process forms an integral part of our understanding of the formulation and implementation of policy in the United States. For all its theoretical importance, however, little work has been done to develop or test the propositions of entrepreneurship offered by Kingdon (1984). By examining the life of Ansel Adams (1902-1984), this paper explores more fully the concept of policy entrepreneurship and seeks to develop a more robust concept that accounts for the long-term, diffuse series of activities that precede Kingdon’s “stream coupling” in the policy process. The analysis suggests that such an approach offers some promise for capturing a broader spectrum of policy activity.
Reducing covariate factors of gait recognition using feature selection and dictionary-based sparse coding

Human gait recognition is a behavioral biometrics method that aims to determine the identity of individuals through the manner and style of their distinctive walk. It is still a very challenging problem because natural human gait is affected by many covariate factors such as changes in the clothing, variations in viewing angle, and changes in carrying condition. This paper evaluates the most important features of gait under the carrying and clothing conditions. We find that the intra-class variations of the features that remain static during the gait cycle affect the recognition accuracy adversely. Thus, we introduce an effective and robust feature selection method based on the gait energy image. The new gait representation is less sensitive to these covariate factors. We also propose an augmentation technique to overcome some of the problems associated with the intra-class gait fluctuations, as well as if the amount of the training data is relatively small. Finally, we use dictionary learning with sparse coding and linear discriminant analysis to seek the best discriminative data representation before feeding it to the Nearest Centroid classifier. When our method is applied on the large CASIA-B gait data set, we are able to outperform existing gait methods by achieving the highest average result.
Caring for a Child With an Obstetric Brachial Plexus Injury: A Metaphor Analysis.

Abstract Purpose The purpose of this study was to examine the metaphors used by mothers to describe their experiences caring for their children with obstetric brachial plexus injuries. Design and Methods A secondary qualitative data analysis was conducted from the primary data set of a phenomenological study of mothers' experiences caring for their children with obstetric brachial plexus injuries. The type of secondary qualitative data analysis approach used was analytic expansion. Metaphor Identification Procedure was used to analyze the corpus of 132 pages of typed transcription. Results This metaphorical analysis yielded seven metaphors mothers used to describe their experiences caring for their children with obstetric brachial plexus injuries. These metaphors portrayed mothers' lives as involving a heavy weight, a maze, a juggling act, a simmering pot, a dagger to the heart, a rollercoaster, and a constant battle. Conclusion The seven metaphors helped women express what they could not completely capture using only medical jargon and provide valuable insight for clinicians. Using secondary qualitative data analysis to mine for any metaphors in a primary data set gives researchers another valuable and creative opportunity to discover new knowledge from the data they had previously collected. Practice Implications Specific interventions can be developed to target each of these seven metaphors to help mothers in their daily care for their children with obstetric brachial plexus injuries.
Relationship between apparent modulus of elasticity, gage length, and tensile strength of lumber

The percent explained variation (r2) of tensile strength (T) of dimension lumber can be accounted for primarily by apparent modulus of elasticity (Ea).
Robust Adaptive Beamforming in Uniform Circular Array

Phase-mode transformation (PMT) is a commonly used technique to convert a uniform circular array (UCA) into a virtual uniform linear array (ULA). This method restores the Vandemonde structure of the steering vector and makes it easy to apply many existing beamforming algorithms to UCA. One such method is the famous Minimum Variance Distortionless Response (MVDR) algorithm, in which the array gain is equal to unity in the direction of arrival of the desired signal. However, due to the approximation errors of the PMT and signal steering vector mismatches, the performance of these algorithms degrades. To address these two issues, in this paper we develop a robust recursive updating algorithm based on worst-case performance optimization. We show that the proposed algorithm belongs to the class of the diagonal loading technique and the transformation matrix belongs to a certain ellipsoid set. Using the Lagrange multiplier method, we have also derived closed-form solution to the weight vector. Our robust algorithm has low implementation complexity and makes the mean output array SINR consistently close to the optimal one. Numerical experiments have shown that our method outperforms the MVDR algorithm.
Resistance to Organizational Change Efforts From a Careers Stages Perspective: A Conceptual Review

This paper highlights that understanding resistance to organizational change efforts could benefit from taking a careers stages view. In mergers and acquisitions, restructuring, and/or other transf...
Validating a prediction modeling tool for left ventricular outflow tract (LVOT) obstruction after transcatheter mitral valve replacement (TMVR)

OBJECTIVE Demonstrate proof-of-concept validation of a computed tomography (CT) computer-aided design prediction modeling tool to identify patients at risk for left ventricular outflow tract (LVOT) obstruction in transcatheter mitral valve replacement (TMVR). BACKGROUND LVOT obstruction is a significant and even fatal consequence of TMVR. METHODS From August 2013 to August 2017, 38 patients in 5 centers underwent TMVR with compassionate use of balloon-expandable valves for severe mitral valve dysfunction because of degenerative surgical mitral ring, bioprosthesis, or severe native mitral stenosis from to severe mitral annular calcification. All patients had preprocedural CT scans performed for anatomic screening, intraprocedural TEE and invasive hemodynamics performed. Preprocedural prediction modeling was performed utilizing computer-aided design (CAD) of the neo-LVOT post-TMVR. Post-TMVR CT scans were obtained and compared to pre-TMVR LVOT modeling datasets for validation. RESULTS All patients underwent successful TMVR without device embolization. Seven of the 38 patients experienced LVOT obstruction, defined as an increase of ≥10 mmHg LVOT peak gradient post-TMVR. Anatomic screening using CT was validated in 20/38 patients as preprocedural predicted neo-LVOT surface area correlated well with post-TMVR measurements (R2 = 0.8169, P < 0.0001). A receiver operating curve curve found a predicted neo-LVOT surface area of ≤ 189.4 mm2 to have 100% sensitivity and 96.8% specificity for predicting TMVR-induced LVOT obstruction. CONCLUSION CAD design and CT postprocessing are indispensable tools in predicting LVOT obstruction and necessary for anatomic screening in percutaneous TMVR.
Maternal body mass index and risk of intraventricular hemorrhage in preterm infants.

Intraventricular hemorrhage (IVH) and pre-pregnancy obesity and underweight have been linked to inflammatory states. We hypothesize that IVH in preterm infants is associated with pre-pregnancy obesity and underweight due to an inflammatory intrauterine environment. Population-based study of infants born between 22 and 32 weeks’ gestation from 2007 to 2011. Data were extracted from vital statistics and the California Perinatal Quality Care Collaborative. Results were examined for all cases (any IVH) and for severe IVH. Among 20,927 infants, 4,818 (23%) had any IVH and 1,514 (7%) had severe IVH. After adjustment for confounders, there was an increased risk of IVH associated with pre-pregnancy obesity, relative risk 1.14 (95% confidence interval (CI) 1.06, 1.32) for any IVH, and 1.25 (85% CI 1.10, 1.42) for severe IVH. The direct effect of pre-pregnancy obesity on any IVH was significant (P<0.001) after controlling for antenatal inflammation-related conditions, but was not significant after controlling for gestational age (P=0.56). Pre-pregnancy obesity was found to be a risk factor for IVH in preterm infants; however, this relationship appeared to be largely mediated through the effect of BMI on gestational age at delivery. The etiology of IVH is complex and it is important to understand the contributing maternal factors.
Reading Fan Art as Complex Texts

Back in 1999, as a newly certified art teacher, I quickly recognized my students' preoccupation with everything Pokemon-related.At first, I discouraged the practice of drawing the cute little monst...
3.4 – Skeletal Muscle Mechanics

This chapter introduces muscle physiology by describing the overall function of muscle to contract or produce force. It begins with a description of the muscle twitch and the mechanical heterogeneity of muscle types—fast-twitch and slow-twitch muscles. It continues to consider how muscle force is graded nearly continuously from low to high levels of force through recruitment of motor units and through the frequency of activation of motor units. It defines the motor unit. It further describes the size principle for the order or recruitment of motor units. It describes how muscle force varies with the length of muscle and points out that this is not a physiologically important way of varying muscle force, but illuminates the mechanism of force production. This chapter then describes the force–velocity relationship and distinguishes among concentric, isometric, and eccentric contractions. It ends with a discussion of pinnation and its function in muscle.
Megavoltage Computed Tomography Imaging

Publisher Summary The most successful integration of megavoltage computed tomography (MVCT) imaging with radiation therapy devices is the TomoTherapy™ Hi-ART. It is currently the only type of patient treatment in which MVCT imaging is integrated as part of the treatment device itself. The Hi-ART II system can generate CT images from the same megavoltage X-ray beam it uses for treatment. These MVCT images offer verification of the patient position prior to and potentially during radiation therapy. The amount of integral dose (total dose in tissue) that the patient receives during MVCT images is dependent on the MVCT slice thickness and total length of the imaged region. The MVCT images need to be registered with the kVCT images in order to establish proper patient positioning. Once the MVCT images are acquired and reconstructed, the radiation therapist (RTT) has the option to use either automatic or manual registration, with the kVCT data set as the primary data set. Axial, sagittal, and coronal views are available on the treatment console to assist the operator during the manual registration process. There are currently three different available MVCT scanning modes—coarse, normal, and fine—which correspond to MVCT image slice thicknesses of 6.0, 4.0, and 2.0 mm, respectively.
DECOMPOSITIONS OF E3 WITH COUNTABLY MANY NON-DEGENERATE ELEMENTS

This chapter presents the decompositions of E 3 with countably many nondegenerate elements. It presents an assumption where G is an upper semi-continuous decomposition of E 3 into points and countably many tame cellular polyhedral. It is shown in the chapter that E 3 / G is a homeomorphic to E 3 . This result extends Bing's theorem, which states that E 3 / G is homeomorphic to E 3 if G is an upper semi-continuous decomposition of E 3 into points and countably many tame arcs. A subset X of E 3 is a tame polyhedron if and only if there is a homeomorphism h of E 3 to itself so that h ( X) is a rectilinear simplical complex.
The Sincerity of Purpose: Sustainability and World Peace

To understand what my grandfather, Mohandas K. Gandhi, meant by sustainable development, you need to understand the philosophy of his life. Gandhi’s very essence was based on the concept of Satyagraha – that is, truth force. For Gandhi, truth was God. Thus, Gandhi’s life involved not just uttering the truth at all times, but living, believing, thinking, and doing nothing but the truth. Gandhi also believed that service of the oppressed was the best form of worship and that poverty is the worst form of violence. In Gandhi’s mind, as long as poverty existed in society, everything else was meaningless. He believed you cannot talk to the poor about freedom, spirituality, morality, or anything else so long as the poor are deprived of the three essentials of life – food, clothing, and shelter.
Rangeland Ecosystems in the Great Plains: Status and Management

Rangeland is defined as land on which the indigenous vegetation (climax or natural potential) is predominantly grasses, grass-like plants, forbs, or shrubs and is managed as a natural ecosystem. If plants are introduced, they are managed as indigenous species. Rangelands include natural grasslands, savannas, shrublands, many deserts, tundras, alpine communities, marshes, and meadows (Forage and Grazing Terminology Committee 1991).
Retinal Phototoxicity from the Operating Microscope: The Role of Inspired Oxygen

Abstract The effect of the inspired oxygen concentration (FI02) on the production of retinal phototoxicity by the operating microscope was studied in phakic rhesus monkeys. One eye of each monkey was exposed to light under conditions of 99% FIO 2 , and the other eye was exposed under 21 % oxygen (O 2 )Three of four locations on each retina were exposed to light for durations varying from 1 1/2 to 20 minutes per exposure. Fundus photographs and fluorescein angiograms were obtained 24 to 72 hours after exposure. Animals were euthanatized for analysis of retinal histopathology at intervals from 2 weeks to 8 months after light exposure. Retinal phototoxic lesions were produced after an average of 5 minutes of light exposure under both 21 and 99% O 2 . O 2 potentiated the light damage both clinically and histologically. Under both conditions, lesion size was directly related to the duration of light exposure ( P 2 were 1.6 to 6.9 (mean, 2.9) times larger than the corresponding lesions formed with 21 % FIO 2 . Histologic damage was likewise more severe in lesions produced under high O 2 conditions. Retinal repair occurred in lesions produced under high and low O 2 conditions. Photoreceptor regeneration was nearly complete by 18 weeks, whereas retinal pigment epithelial (RPE) recovery lagged up to 11/2 months. The results of this study have important implications for clinical practice: the operating microscope can produce retinal phototoxicity rapidly, and O 2 administered during ophthalmic procedures may potentiate the damage if appropriate precautions are not taken.
Ultrastructural studies in acute promyelocytic leukemia.

In this investigation, the cells of eight patients with acute promyelocytic leukemia were followed by light and electron microscopy. Promyelocytes from untreated patients were filled with large, splinter-shaped granules. The granules were lysosomes, with some showing the ultrastructural features of Auer bodies. In cases responsive to chemotherapy, promyelocytes contained only infrequently splinter-shaped lysosomes, while most lysosomes were of more uniform size and shape. The persistence of large numbers of splinter-shaped lysosomes within promyelocytes was associated with episodes of disseminated intravascular coagulation less responsive to heparin treatment. Promyelocytes from patients in remission were similar to promyeloctyes from nonleukemic bone marrow. The ultrastructural differences in lysosome morphology provide a better criterion for distinguishing malignant from normal promyelocytes than previously detectable by light microscopy alone.
Narrow Angle Wide Spectral Range Radiometer Design Feanics/Reefs: Radiometer Design Report

A critical measurement for the Radiative Enhancement Effects on Flame Spread (REEFS) microgravity combustion experiment is the net radiative flux emitted from the gases and from the solid fuel bed. These quantities are measured using a set of narrow angle, wide spectral range radiometers. The radiometers are required to have an angular field of view of 1.2 degrees and measure over the spectral range of 0.6 to 30 microns, which presents a challenging design effort. This report details the design of this radiometer system including field of view, radiometer response, radiometric calculations, temperature effects, error sources, baffling and amplifiers. This report presents some radiometer specific data but does not present any REEFS experiment data.
Infectious Disease in Wild Animal Populations: Examining Transmission and Control with Mathematical Models

The mathematical modeling of ecological interactions is an essential tool in predicting the behavior of complex systems across landscapes. The scientific literature is growing with examples of models used to explore predator-prey interactions, resource selection, population growth, and dynamics of disease transmission. These models provide managers with an efficient alternative means of testing new management and control strategies without resorting to empirical testing that is often costly, time-consuming, and impractical. This chapter presents a review of four types of mathematical models used to understand and predict the spread of infectious diseases in wild animals: compartmental, metapopulation, spatial, and contact network models. Descriptions of each model’s uses and limitations are used to provide a look at the complexities involved in modeling the spread of diseases and the trade-offs that accompany selecting one modeling approach over another. Potential avenues for the improvement and use of these models in future studies are also discussed, as are specific examples of how each type of model has improved our understanding of infectious diseases in populations of wild animals.
Metastatic seeding of the stereotactic biopsy tract in glioblastoma multiforme: case report and review of the literature.

Objective and importance. The first case was recently reported of tumor seeding by glioblastoma multiforme (GBM) after stereotactic biopsy. This occurred despite radiosurgical treatment of the lesion post-biopsy. We report the first case of metastatic seeding along the needle biopsy tract of a GBM in which the tract was within the treatment field of subsequent fractionated radiation therapy.
Solute/Twin boundary interaction as a new atomic-scale mechanism for Dynamic Strain Aging

Abstract Twinning is an important mechanism during the plastic deformation of materials with hexagonal-close-packed crystal structure. Strength and formability are critical properties for this family of structural materials and can consequently be improved by controlling twin nucleation and growth. Here, we study the effect of alloying elements on strain rate and temperature dependence of twin growth. Without using any fitting parameters, we derive an analytical model which takes atomic scale calculated parameters as input and predicts the equilibrium concentration of segregated solutes and strengthening due to solute-twin interactions. This model predicts the strain-rate/temperature conditions of negative strain rate sensitivity in titanium, under loading conditions that favor twinning, with oxygen interstitial. The predictions are in agreement with available experiments. Our findings present a new mechanism for dynamic strain aging as a result of solute segregation to the twin boundaries.
Solving the Plastics Problem: Moving the U.S. from Recycling to Reduction

In this Policy Brief, we argue that current U.S. waste disposal strategies (recycling, displacement and disposal) do not address waste reduction, are perceived as socially unfair, and cannot keep p...
Definitions more geometrarum and Newton's scholium on space and time

Abstract Newton's Principia begins with eight formal definitions and a scholium, the so-called scholium on space and time. Despite a history of misinterpretation, scholars now largely agree that the purpose of the scholium is to establish and defend the definitions of key concepts. There is no consensus, however, on how those definitions differ in kind from the Principia's formal definitions and why they are set-off in a scholium. The purpose of the present essay is to shed light on the scholium by focusing on Newton's notion and use of definition. The resulting view is developmental. I argue that when Newton first wrote the Principia, he viewed the scholium's definitions as items of “natural philosophy.” By the time of the third edition, however, he came to view their methodological status differently; he viewed them as belonging to the more qualified “manner of geometers.” I explicate the two methods of natural inquiry and draw out their implications for Newton's account of space.
Covid-19 positivity affects outcome of cardiac surgical patients.

INTRODUCTION: In this report we describe the clinical presentation, laboratory findings and outcomes of four patients that were referred for urgent cardiothoracic intervention and tested positive for COVID-19. METHODS: The St. Elizabeth's Medical Center Institutional Review Board exempted the study from review (waived review). In each case, verbal informed consent was obtained by the study participant or health care proxy. RESULTS: The majority of the patients undergoing surgery had low Society of Thoracic Surgeons score and uneventful operating time. The mortality was very high and driven primarily by the viral syndrome. Laboratory markers that have been associated with disease severity in the general population were also prognostic in our population. CONCLUSION: Our study shows that these patients have very high mortality, whereas prevention and preoperative screening is required in preventing nosocomial spreading of the disease.