cssi/SciSciGPT-SciSciNet huggingface dataset:
Transitions to Assisted Living: A Pilot Study of Residents’ Occupational Perspectives

ABSTRACTAssisted living is one of the fastest growing housing options in the United States with over one million older persons transitioning to assisted living facilities. This pilot study used mixed methods to explore the perspectives of 10 older persons who transitioned to an assisted living facility. A semistructured interview, the Canadian Occupational Performance Measure (COPM), and the RAND 36-Item Health Survey (RAND 36) were used for data collection. This study employed a novel use of the COPM as a test of satisfaction with role engagement instead of a measure of pre- and postintervention role performance and satisfaction. Results suggest occupational integrity, role maintenance; choice and satisfaction with role performance may be related to successful transition and suggest a potential role for occupational therapists in facilitating residents’ adjustment to assisted living.
Computational modeling of vibration damping in SMA wires

Through a mathematical and computational model of the physical behavior of shape memory alloy wires, this study shows that localized heating and cooling of such materials provide an effective means of damping vibrational energy. The thermally induced pseudo-elastic behavior of a shape memory wire is modeled using a continuum thermodynamic model and solved computationally as described by the authors in [23]. Computational experiments confirm that up to \(80\%\) of an initial shock of vibrational energy can be eliminated at the onset of a thermally-induced phase transformation through the use of spatially-distributed transformation regions along the length of a shape memory alloy wire.
Normal Peroxidase Activity in Pendred's Syndrome

A 12-year-old euthyroid girl with a goiter and bilateral nerve deafness had a 29% discharge of radioiodide after perchlorate. Both parents and five siblings were euthyroid with goiter and nerve deafness, and all but the father had a positive perchlorate discharge of radioiodide. Thyroid tissue obtained during subtotal thyroidectomy contained ample peroxidase activity as measured by I3– formation and 131I incorporation into tyrosine, both of which were stimulated by the addition of hematin. There was a low iodine content in the gland which probably accounted for an increase in MIT/DIT ratio and decrease in the amount of radioiodine found in the iodothyronines, after it had been labelled in vivo with 125I. The thyroglobulin appeared to be normal by its saltingout behavior, chromatography on Sephadex G-200 and immunodiffusion. The findings suggest that the defect in the iodinating mechanism in Pendred's syndrome is a deficiency other than peroxidase activity.
Calorimetric output power measurements on a CW 20 kW 7.16 GHz microwave transmitter

A calorimetric measurement technique developed for NASA's Deep Space Network (DSN) transmitters that does not require data on the coolant's thermal parameters is described. Calibration of the measurement system is achieved by measuring the DC input power to the klystron and relating coolant temperature increase to this known power dissipation. Agreement between calorimetric and electrical measurements of total system power was good, the difference being less than 2%. The operation of the system was not greatly affected by the composition of the coolant, which was varied from pure water to 40% ethylene glycol by mass. Good accuracy was also shown at output power levels, which varied over a 3.6:1 range. >
Effect of the cytoskeletal prestress on the mechanical impedance of cultured airway smooth muscle cells

We investigated the effect of the cytoskeletal prestress (P) on the elastic and frictional properties of cultured human airway smooth muscle cells during oscillatory loading; P is preexisting tensi...
Ecological Consequences of Long-Term Exposure of Anabaena variabilis (Cyanophyceae) to Shifts in Environmental Factors.

Cultures of Anabaena variabilis were exposed to different light intensities, and the time course of photoadaptation was measured by photosynthetic rate and changes in pigmentation. A shift down in intensity of 284 μEin · m−2 · sec−1 caused a temporary decrease in the photosynthetic response followed by gradual adaptation to the new conditions. Final chlorophyll a and carotenoid concentrations were reached after 1 day, although other physiological indicators showed that adaptation required 4 days. The parameter Ik was shown to be the best indicator of photoadaptation. A shift up in light intensity of the same magnitude also required 4 days for complete photoadaptation by the culture, although chlorophyll and carotenoid concentrations stabilized within 1 day. A shift down in light intensity of 392 μEin · m−2 · sec−1 resulted in a temporary attempt to adapt followed by collapse of the population. This demonstrates an apparent threshold in the magnitude of the shift in light intensity which will permit successful adaptation. Simultaneous changes in light intensity and temperature also adversely affected culture populations. Our observations present a possible cause for the decline or prevention of an algal bloom under a fluctuating light regime and suggest that it may be possible to predict this decline as a result of synoptic weather patterns or hydrodynamic influences.
Academic performance of young children in immigrant families: The significance of race, ethnicity, and national origins

Children of immigrants come from diverse backgrounds and enter school with different family migration experiences and resources. This paper addresses two basic questions: (1) to what extent does generation status exert an independent effect on early school performance net of race/panethnicity, language proficiency, and the family resources available to children as they enter formal schooling? and (2) to what extent do these broad conceptualizations of children in immigrant families mask variation by national origins? We take advantage of longitudinal data on a kindergarten cohort from the Early Childhood Longitudinal Study to examine children from diverse backgrounds. Considerable variation in academic performance persists across racial/panethnic groups as well as by country-of-origin background and linguistic ability even when adjusting for family background, resources, and previous academic performance. We find some intriguing evidence of early “segmentation” among children from various groups, suggesting some convergence within race and ethnicity for some children. However, this conclusion should not be overstated, because the results also point to the great diversity by national origins that are masked by reliance on racial/panethnic groupings.
Nano metal particles for low temperature interconnect technology

For low temperature interconnects, melting point (T/sub m/) depression and sintering behavior of metal nano particles are investigated. Nano Ag particles used (/spl sim/20 nm) exhibited obvious sintering behavior, rather than typical melting behavior, at significantly lower temperatures (/spl sim/150 /spl deg/C) than its T/sub m/ (1235/spl deg/C) . The particle surface was characterized by XPS, FTIR and TGA. The thermal behavior was studied by DSC and TGA. The crystal structure of the particle was examined by XRD. The shrinkage of the nano particles during sintering was monitored by TMA. Sintering behavior of the nano particles is discussed.
Efficient Energy Stable Schemes with Spectral Discretization in Space for Anisotropic Cahn-Hilliard Systems

We develop in this paper efficient and robust numerical methods for solv- ing anisotropic Cahn-Hilliard systems. We construct energy stable schemes for the time discretization of the highly nonlinear anisotropic Cahn-Hilliard systems by using a stabilization technique. At each time step, these schemes lead to a sequence of lin- ear coupled elliptic equations with constant coefficients that can be efficiently solved by using a spectral-Galerkin method. We present numerical results that are consis- tent with earlier work on this topic, and also carry out various simulations, such as the linear bi-Laplacian regularization and the nonlinear Willmore regularization, to demonstrate the efficiency and robustness of the new schemes.
Deficits, delays, and distractions: an evaluation of symbolic play and memory in children with autism

Two experiments were conducted to evaluate symbolic-deficit and memory-deficit hypotheses to account for the cognitive problems seen in children with autism. Experiment 1 tested imitation, in immediate and deferred conditions, of familiar actions with different sets of objects representing the developmental progression from functional to symbolic play. The results showed that the autism group and both their receptive language and nonverbal IQ-matched controls imitated familiar actions with realistic objects (evidence for functional play) and placeholder objects (evidence for symbolic play) after delays ranging from 24 hr to 3 weeks. Experiment 2 tested familiar three-step event sequences in which a placeholder object was substituted for the second step in half the events. The results showed that the autism group remembered as many of the actions with the placeholder objects as their language-matched controls and as many correctly ordered sequences, a finding that supports a symbolic-delay (rather than deficit) hypothesis. These results were obtained in highly structured test situations and sharply contrast with the impairments seen in children with autism who are observed in naturalistic settings. Two interpretations of these findings are offered. First, structured test settings minimize distractions that typically occur in naturalistic settings that may interfere or disrupt symbolic play in children with autism. Second, the results are consistent with an executive function deficit in that the autistic group demonstrated more knowledge in the test settings than they demonstrate spontaneously in naturalistic ones.
DNA: is the backbone boring?

The old question: 'is DNA really a double helix?' has recently been re-hashed, and, not surprisingly, the Watson-Crick double-helical B structure for DNA has been re-affirmed [1,2]. However, the cen- tral question of the overall structure of DNA should not distract us to such an extent that we overlook other more subtle aspects of the structure of this most import- ant molecule. One such aspect is the nature of the sugar-phosphate backbone in DNA. Is it a boring regular repetition as envis- aged in the Watson-Crick structure, or can it also exhibit significant informational properties? Several authors have speculated that the DNA backbone might exhibit eonforma- tional alternations depending on the base sequence. As a result of a variety of studies evidence has now been accumulated to support such a contention.
Forced Convection Heat Transfer from Horizontal Cylinders in a Rarefied Gas

An approximate analytical treatment of the energy equation is given which yields a specification for the average heat-transfer coefficients from horizontal circular cylinders to gases flowing at high Mach Numbers and low Reynolds Numbers. The results are given for continuum and slip-flow regions in comparison with available experimental data.
Does a Nurse-Driven Protocol for Urinary Catheter Removal Empower Nurses to Remove Urinary Catheters Without a Physician Order?

Project: A multi-disciplinary team, consisting of Infection Prevention, Clinical Educators, Quality Management, and Nursing Staff, designed visual cues and a checklist for UC removal. A pilot was conducted on a Medical Surgical Unit utilizing bright yellow magnets as visual cues on the patient census boards. The magnets indicated POD 1 or POD 2 as a reminder to obtain an order to remove the UC. The team also proposed to the Medical Board a physician approved guideline for appropriate UC removal using evidence based criteria. The guideline outlined specific criteria for nursing to continue or remove the UC. Approval was obtained fromMedical Staff for a pilot in the Critical Care Unit; after a two week trial, the pilot was extended hospital wide.
Corticosteroid treatment of periorbital haemangioma of infancy: a review of the evidence.

Aim: To systematically review the literature for corticosteroid treatment of periorbital haemangioma of infancy (HOI) and determine the relative efficacy and safety of oral, topical and intralesional corticosteroids. Methods: PubMed and the Cochrane Library were queried using keywords, and further articles were obtained by reviewing bibliographies. Inclusion and exclusion criteria were applied to create a subset of literature for analysis. Results: Systematic review revealed 81 original reports of periorbital HOI cases treated with steroids. Most studies and case series failed to document refractive error or visual acuity before and after treatment. Of cases meeting inclusion criteria, five patients received topical steroids and 25 patients received intralesional steroids. Patients receiving intralesional injections tended to demonstrate reduced astigmatism at follow up after treatment (21 of 28). The lack of studies with relevant objective ophthalmological end points prevented statistical meta-analysis. Conclusion: Intralesional injections may reduce refractive error, while the efficacy of topical steroids is unclear. Studies measuring objective ophthalmic data before and after treatment are sparse, and more studies are needed to determine the relative efficacy of different steroids. There are insufficient data to estimate the incidence of steroid side effects in patients treated with steroids for periorbital HOI or complications of intralesional injections in particular.
High Resolution Correlation of the Upper Cretaceous Stratigraphy Between the Book Cliffs and the Western Henry Mountains Syncline, Utah, U.S.A.

Abstract Exposures of Upper Cretaceous strata in the Book Cliffs have played a key role in the formulation of modern sequence stratigraphic concepts, and yet correlations with time-equivalent strata in nearby regions remain uncertain, resulting in an incomplete understanding of regional paleogeography. This study presents detailed high-resolution correlations of the Upper Cretaceous stratigraphy between the Book Cliffs, the Wasatch Plateau, and the western Henry Mountains Syncline in Utah with emphasis on the Campanian interval. Two newly acquired measured vertical sections at Coal Canyon near Green River, in the Book Cliffs, and Blind Trail, in the Henry Mountains, inform the correlations, which also incorporate the substantial body of previous research. Correlations are further constrained by vertical and lateral facies stacking patterns, and changes in sediment dispersal directions at discrete stratigraphic horizons derived from paleocurrent measurements. Much of the Campanian succession can be characterized as a single, low-frequency (third order) depositional sequence, within which are nested numerous high-frequency sequences. While it is not possible to correlate every high-frequency sequence recognized in individual outcrop areas, we define four intervals (numbered 1–4, in ascending stratigraphic order) that we correlate across the entire region. Interval 1 (basal Campanian) is represented by initially deltaic and later wave-dominated shoreface strata of the Star Point Sandstone and equivalent basal Muley Canyon Sandstone. Interval 2 (lower Campanian) comprises coastal-plain facies passing eastward into shallow marine strata of the lower Blackhawk Formation and equivalent Muley Canyon Sandstone. Interval 3 (lower to mid middle Campanian) comprises a thick aggradational stack of coastal-plain fluvial strata that pass eastward into coastal and shallow marine facies (Blackhawk Formation and equivalent Masuk Formation). Interval 4, overlying a major facies dislocation (third-order sequence boundary), comprises amalgamated sheet fluvial deposits of the lower Castlegate Sandstone and equivalent Tarantula Mesa Sandstone. During the early to middle Campanian, the northern Wasatch Plateau and western Henry Mountains regions were along depositional strike with respect to one another. The Book Cliffs near Green River were located obliquely down depositional dip from the western Henry Mountains region during the Campanian. These new correlations, and the improved understanding of paleogeography that derive from them, have the potential to inform basin-scale stratigraphic interpretations to a greater extent than has been hitherto possible.
A FAST FLARE AND DIRECT REDSHIFT CONSTRAINT IN FAR-ULTRAVIOLET SPECTRA OF THE BLAZAR S5 0716+714

The BL Lacertae object S5 0716+714 is one of the most studied blazars on the sky due to its active variability and brightness in many bands, including very-high-energy gamma rays. We present here two serendipitous results from recent far-ultraviolet spectroscopic observations by the Cosmic Origins Spectrograph onboard the Hubble Space Telescope (HST). First, during the course of our 7.3 hr HST observations, the blazar increased in flux rapidly by {approx}40% (-0.45 mag hr{sup -1}) followed by a slower decline (+0.36 mag hr{sup -1}) to previous FUV flux levels. We model this flare using asymmetric flare templates and constrain the physical size and energetics of the emitting region. Furthermore, the spectral index of the object softens considerably during the course of the flare from {alpha}{sub {nu}} Almost-Equal-To -1.0 to {alpha}{sub {nu}} Almost-Equal-To -1.4. Second, we constrain the source redshift directly using the {approx}30 intervening absorption systems. A system at z = 0.2315 is detected in Ly{alpha}, Ly{beta}, O VI, and N V and defines the lower bound on the source redshift. No absorbers are seen in the remaining spectral coverage (0.2315 < z {sub Ly{alpha}} {approx}< 0.47) and we set a statistical upper bound of z < 0.322 (95% confidence) onmore » the blazar. This is the first direct redshift limit for this object and is consistent with literature estimates of z = 0.31 {+-} 0.08 based on the detection of a host galaxy.« less
Spatio-temporal background models for outdoor surveillance

Video surveillance in outdoor areas is hampered by consistent background motion which defeats systems that use motion to identify intruders. While algorithms exist for masking out regions with motion, a better approach is to develop a statistical model of the typical dynamic video appearance. This allows the detection of potential intruders even in front of trees and grass waving in the wind, waves across a lake, or cars moving past. In this paper we present a general framework for the identification of anomalies in video, and a comparison of statistical models that characterize the local video dynamics at each pixel neighborhood. A real-time implementation of these algorithms runs on an 800MHz laptop, and we present qualitative results in many application domains.
Thermodynamic modeling of the aluminum–iron–oxygen system

Abstract The aluminum–iron–oxygen (Al–Fe–O) system is an important subsystem within several material classes, especially when considering oxidation of high-performance structural materials or deoxidation of steels during steelmaking. Despite its industrial importance as well as the large amount of experimental information available in literature, no complete phase diagram has been reported for this system. Therefore, a thermodynamic description, by means of the CALPHAD method, is developed in this study. To account for the complexity of the solid oxides including non-stoichiometry, solid solution in the phases and cation distribution between different lattice sites, the compound energy formalism is applied for the modeling. The liquid phase is modeled utilizing the ionic two-sublattice model. The sublattice models are selected with the aim to achieve compatibility with the Al–Ni–O and Fe–Ni–O systems to facility development of a quaternary thermodynamic description. The evaluated model is validated by comparison to available experimental data. Satisfactory agreement with both thermochemical and phase equilibrium data is concluded.
Impact of Assimilating Surface Velocity Observations on the Model Sea Surface Height Using the NCOM-4DVAR*

AbstractThe assimilation of surface velocity observations and their impact on the model sea surface height (SSH) is examined using an operational regional ocean model and its four-dimensional variational data assimilation (4DVAR) analysis component. In this work, drifter-derived surface velocity observations are assimilated into the Navy’s Coastal Ocean Model (NCOM) 4DVAR in weak-constraint mode for a Gulf of Mexico (GoM) experiment during August–September 2012. During this period the model is trained by assimilating surface velocity observations (in a series of 96-h assimilation windows), which is followed by a 30-day forecast through the month of October 2012. A free-run model and a model that assimilates along-track SSH observations are also run as baseline experiments to which the other experiments are compared. It is shown here that the assimilation of surface velocity measurements has a substantial impact on improving the model representation of the forecast SSH on par with the experiment that assim...
Case-Based Learning in Athletic Training.

The National Athletic Trainers’ Association (NATA) Executive Committee for Education has emphasized the need for proper recognition and management of orthopaedic and general medical conditions through their support of numerous learning objectives and the clinical integrated proficiencies. These learning objectives and integrated clinical proficiencies are designed to prepare athletic training students to become competent professionals. In fact, the educational competencies and integrated proficiencies related to orthopaedic clinical assessment and diagnosis are just one of the vital links in becoming either a successful or an unsuccessful athletic trainer. However, this success is not accomplished overnight; rather, it is accomplished gradually over time, as students progress through the higher levels of Bloom’s taxonomy.
Resonances in /sup 12/C + /sup 9/Be

Excitation functions for the $^{12}\mathrm{C}$ + $^{9}\mathrm{Be}$ system have been measured for the elastic, inelastic, alpha particle, and $^{8}\mathrm{Be}$ exit channels from ${E}_{\mathrm{c}.\mathrm{m}.}=10 \mathrm{to} 15$ MeV. Resonances with widths of approximately 800 keV were identified at center-of-mass energies of 11.2, 11.5, 12.6, 13.8, and 14.5 MeV.NUCLEAR REACTIONS Measured $\frac{d\ensuremath{\sigma}}{d\ensuremath{\Omega}}$ for ${E}_{\mathrm{c}.\mathrm{m}.}=10 \mathrm{to} 15$ MeV for $^{12}\mathrm{C}$($^{9}\mathrm{Be}$, $^{9}\mathrm{Be}$)-$^{12}\mathrm{C}$ (g.s., 4.43 MeV) at ${\ensuremath{\theta}}_{\mathrm{c}.\mathrm{m}.}\ensuremath{\simeq}100\ifmmode^\circ\else\textdegree\fi{} \mathrm{to} 151\ifmmode^\circ\else\textdegree\fi{}$, $^{9}\mathrm{Be}$($^{12}\mathrm{C}$, $^{8}\mathrm{Be}$)$^{13}\mathrm{C}$ at ${\ensuremath{\theta}}_{\mathrm{c}.\mathrm{m}.}\ensuremath{\simeq}13\ifmmode^\circ\else\textdegree\fi{} \mathrm{to} 75\ifmmode^\circ\else\textdegree\fi{}$, and $^{12}\mathrm{C}(^{9}\mathrm{Be}, \ensuremath{\alpha})^{17}\mathrm{O}$ at ${\ensuremath{\theta}}_{\mathrm{c}.\mathrm{m}.}\ensuremath{\simeq}19\ifmmode^\circ\else\textdegree\fi{} \mathrm{to} 70\ifmmode^\circ\else\textdegree\fi{}$. Determined energies and widths of resonant enhancements.
Cellular Recognition and Transduction of Fluid Mechanical Shear Stress Signals

Hemodynamic forces associated with blood flow provide an important potential influence on both the physiology and pathophysiology of the cardiovascular system. As the lining of the entire cardiovascular system, the endothelium is uniquely positioned to be the sensor, responder, and transducer of these hemodynamic signals. A major component of the hemodynamic forces which impact upon the vascular endothelium is fluid-imposed wall shear stress. Since the magnitude of this shear stress is dependent upon both the velocity of blood flow across the endothelial surface as well as the geometry of the vascular bed, the shear stress magnitude experience by endothelium varies greatly even within a specific vascular segment. For example, the endothelium residing within the branch points of the abdominal aorta experience much different wall shear stress levels than endothelium residing in straight channels of the same vessel. It is this diversity of shear stress and its correlation with focal differences in arterial physiology and pathology, that has led to the hypothesis that hemodynamic shear stress may modulate the physiology of the vascular wall as well as play a key role in the pathogenesis of diseases such as atherosclerosis.
Unforgotten: Love and the Culture of Dementia Care in India, by Bianca Brijnath

People like me who have served as caregivers for beloved family members suffering from dementia will quickly realise that Bianca Brijnath ‘gets it’. More than once this extraordinary book moved me ...
Is fluid-phase endocytosis conserved in hepatocytes of species acclimated and adapted to different temperatures?

Our primary objective was to determine if rates of fluid-phase endocytosis (FPE) were conserved in hepatocytes from organisms acclimated and adapted to different temperatures. To this aim, the fluo...
Factors associated with bariatric postoperative emergency department visits.

Abstract Background Unplanned bariatric postoperative emergency department (ED) visits occur frequently and may represent inadequate coordination of postdischarge care. Multicenter data on this outcome is limited, as this metric has not traditionally been tracked in large clinical databases. Objectives To describe the frequency of and risk factors associated with 90-day postoperative ED visits after bariatric surgery. Setting Truven Health Analytics MarketScan database. Methods All patients undergoing primary bariatric operations in the 2012 and 2013 MarketScan database were included. The primary outcome was the presence of an ED visit not resulting in a hospital readmission within 90 days of surgical discharge. Risk factors and demographic characteristics evaluated included age, sex, co-morbidities, insurance type, region, operation type, prior ED visits within 1 year, and index admission length of stay. Results Postoperative ED visits not associated with an inpatient admission occurred in 14.6% of patients. The most common diagnoses associated with these visits were abdominal pain (24.4%) and dehydration, nausea, or vomiting (20.8%). On multivariate analysis, younger age, female sex, greater number of co-morbidities, north-central region, open bariatric or laparoscopic gastric bypass operations,≥2 prior ED visits, and increased initial length of stay were all associated with increased odds of an ED visit. Conclusions Postoperative ED visits are a frequent and potentially preventable occurrence with several risk factors. Tracking this metric as a quality indicator will allow for targeted interventions to improve the transition of care to the outpatient setting after bariatric surgery.
Abstract 64: Development of homogeneous non-radioactive assays for studying histone 3 methyltransferases and demethylases

Proceedings: AACR 102nd Annual Meeting 2011‐‐ Apr 2‐6, 2011; Orlando, FL Post-translational modifications of histones are among the epigenetic mechanisms that can affect chromatin structure and function. Disruption of epigenetic processes can lead to altered gene expression and malignant cellular transformation. Epigenetic changes including histone acetylation, histone methylation and DNA methylation are now considered to play important roles in the initiation and progression of cancer. Histone methylation and demethylation are enzymatically dynamic processes controlled respectively by histone methyltransferases (HMTs) and histone demethylases (HDMs). Several assay methods have been developed for quantifying the activity of HMTs and HDMs. These include radioactive assays, enzyme-linked immunoassays (ELISA), mass spectrometry, and enzyme-coupled detection of reaction co-products (e.g. S-adenosylhomocysteine, formaldehyde, hydrogen peroxide). These assays suffer from various drawbacks such as low throughput, lack of sensitivity, generation of hazardous waste, requirement for expensive equipment, or artifacts associated with the use of enzyme-coupled assays (generation of false positives/negatives). In this study, we describe homogeneous (mix-and-read) assays for measuring the catalytic activity of both HMTs and HDMs acting on histone H3 using two different non-radioactive technologies: amplified luminescent proximity homogeneous assay (AlphaLISA) and time-resolved fluorescence energy transfer (LANCE). The EZH2 complex (which methylates histone H3 on lysine 27) and LSD1 and JMJD2A (which demethylate di-methyl lysine 4 and tri-methyl lysine 36, respectively, on histone H3) were selected as model enzymes due to their association with various human diseases. Assays were developed in 384-well format and used as substrates two synthetic biotinylated peptides derived from the N-terminus of histone H3 (amino acids 1 to 21 for LSD1 and 21 to 44 for EZH2 and JMJD2A). All assays were designed as signal-increase homogeneous assays, where direct detection of product formation was conducted using methyl-state selective antibodies conjugated to either AlphaLISA acceptor beads or LANCE europium chelate. Results demonstrated that all assays were sensitive and robust. Furthermore, profiling of known inhibitors for each epigenetic enzyme showed the expected potency with either technology. These assays will therefore be ideal for the identification of selective small molecule inhibitors.Although these studies focused on EZH2, JMJD2A and LSD1 enzymes, the approach described here is broadly suitable for measuring the catalytic activity of other HMTs and HDMTs by combining the appropriate biotinylated histone-derived peptides and methyl-state selective antibodies. Citation Format: {Authors}. {Abstract title} [abstract]. In: Proceedings of the 102nd Annual Meeting of the American Association for Cancer Research; 2011 Apr 2-6; Orlando, FL. Philadelphia (PA): AACR; Cancer Res 2011;71(8 Suppl):Abstract nr 64. doi:10.1158/1538-7445.AM2011-64
Redescription of Aphis mimuli Oestlund (1887) and a New Name for a Misidentified Redescription

Aphis mimuli Oestlund (1887) is redescribed, and a lectotype is designated. Aphis mimuli Hille Ris Lambers (1974) (not Oestlund) is provided with the new name Aphis costalis .
Study on the effects of Chinese herbal drugs by inhalation on inflammatory index in rat model of asthma

Objective To study the effect and immunological mechanism of chinese herbal drugs by inhalation on inflammatory index in rat model of asthma. Methods Wistar rats of 8-10 weeks of age were selected randomly and divided into five groups,TCM group,Dex 1 group,Dex 2 group,Asthma group and Control group,15 rats for each group.Finally rat model of asthma was made by using OVA and Al(OH)3.In the period of chanllenge,a chinese herbal solution was used comprised with bitter Apricot Seed, liquoric Root etc in TCM group.While in other group dexamethasone was injected or inhalated or NS replacing dexamethasone.Finally,it was performed to count the eosinophil in BALF,to detect level of serum OVA specific-IgE. Results There is a significant difference of the percentage of eosinophil in BALF ,the level of serum OVA specific-IgE in TCM group,Dex1 group,Dex2 group between asthma group.And so is there between TCM group,Dex1 group and Dex2 group. Conclusion The solution of chinese herbal drugs in this study has the effect of anti-inflammation which can decrease the eosinophil percentage in BALF,the level of OVA specific-IgE and level of IL-4.The effect of it is equivalent to that of dexthamisasone inhalation.But there is a difference between TCM group and Dex 2 group.Further study should be performed in the research of utensil ingredient and the way to combination of diagnosis/treatment with it.
Discussion on the Relationship between Functional Department and Quality Control

The costs for lacking quality control for enterprises include those that can be clearly accounted,for example, the costs on tests,experiment,rejects,rework,and customer complaints,and those that can t be accounted and normally very high,such as the costs on the manager,designers,purchasers,supervisors and salesmen.This paper investigates the influence of functional department on quality control,makes clear the relationship between the two to coordinate the relationship of functional department to improve the quality level.
Role of protein kinases in regulating sheep erythrocyte K-Cl cotransport

K-Cl cotransport in sheep erythrocytes can be activated by treatment either with A-23187 and EDTA to reduce concentration of internal ionized Mg [Mg]i) to submicromolar levels, with staurosporine, a potent kinase inhibitor, or with N-ethylmaleimide (NEM). Activation by these maneuvers is prevented and reversed by genistein [inhibition constant (Ki) of 15 microM], which inhibits tyrosine kinases (TK). The related glycosidated compound genistin, which does not inhibit TK, does not inhibit transport, whereas another TK inhibitor, tyrphostin B46, inhibits both basal and stimulated transport (Ki of 28 microM). Cotransport activation by NEM is prevented and reversed by the phosphatase inhibitor, calyculin A, and activation by staurosporine occurs only if cells contain ATP. Increasing [Mg]i inhibits cotransport in the presence of calyculin A whether or not staurosporine is present as well. Our work suggests that genistein inhibits cotransport through a TK and that staurosporine and NEM activate cotransport, probably through inhibition of other kinases, causing stimulation through dephosphorylation of a protein (possibly the transporter itself) be a serine/threonine phosphatase. [Mg]i inhibits cotransport by activating a kinase (concentration for half-maximal activation of 10 microM) that phosphorylates this protein.
Impact of preoperative expectations and fear of movement on return to sport and KOOS scores at 6 months following ACL reconstruction

Objectives:Limited research has examined the independent relationship between psychosocial factors and patient-reported outcomes during the early postoperative period following ACL reconstruction (...
Discriminative stimulus effects of zolpidem in squirrel monkeys: role of GABAA/α1 receptors

Abstract Rationale. The discriminative stimulus effects of zolpidem in squirrel monkeys trained at doses greater than or equal to 3.0 mg/kg differ from those of conventional benzodiazepines (BZs), but the extent to which these effects reflect the selectivity of zolpidem for GABAA/α1 receptors is not known. Objectives. The present study investigated the ability of GABAA/α1-preferring agonists to substitute for training doses of zolpidem greater than or equal to 3.0 mg/kg and the ability of GABAA/α1-preferring antagonists to block zolpidem's discriminative stimulus effects. Methods. Squirrel monkeys were trained to discriminate intravenous injections of zolpidem (3.0 or 5.6 mg/kg) from saline and tested with BZ agonists differing in selectivity and efficacy at GABAA/α1 receptors. Antagonism of the effects of zolpidem was studied using the GABAA/α1-preferring antagonists β-carboline-3-carboxylate-t-butyl ester (β-CCT) and 3-propyloxy-β-carboline (3-PBC). Results. Zolpidem and quazepam (GABAA/α1-preferring agonist) engendered full substitution for zolpidem, whereas CL 218,872 (GABAA/α1-preferring partial agonist) and the non-selective BZ agonists alprazolam and flunitrazepam engendered low and variable levels of zolpidem-lever responding (35–58%). Both β-CCT and 3-PBC antagonized the discriminative stimulus effects of zolpidem in a surmountable fashion. Conclusions. Our findings provide evidence for a key role of GABAA/α1 receptors in the discriminative stimulus effects of zolpidem at relatively high training doses, and suggest that selectivity and relatively high efficacy at GABAA/α1 receptors is required for BZ agonists to reproduce these discriminative stimulus effects.
Myosin II Head Interaction in Primitive Species

Myosin II is a two-headed motor protein with an elongated α-helical tail. The motor domain of each head interacts with actin to convert the chemical energy of ATP into movement. Myosin II activity in muscle and nonmuscle cells is switched off by intramolecular interaction between its two heads, which inhibits their activity. This has been shown by EM and image processing of myosin filaments and isolated myosin molecules. In switched-off single molecules, the myosin tail folds into three segments, with the interacting heads folded back on the tail. The interacting-heads motif is highly conserved, being found in vertebrate and invertebrate smooth and striated muscle and in nonmuscle cells. We are investigating its evolutionary origins by EM imaging of isolated myosin molecules in the off-state. In previous work we found that the motif was present as far back as Cnidaria (sea anemones), the earliest animals with muscles. Here we have studied additional animal and non-animal species. At high (0.5 M) salt, all the myosin IIs showed the typical appearance of an extended tail and non-interacting heads. At low salt (0.15 M), under relaxing conditions (MgATP), insect indirect flight and embryonic skeletal muscle myosins showed a folded tail and similar head-head interactions to other muscles. Three species of primitive, non-animal myosins gave differing results. Acanthamoeba (reported previously) and Schizosaccharomyces pombe showed extended tails and no head-head interactions. The tails of these two myosins were approximately 30-40% shorter than the animal myosins, possibly accounting for their inability to fold. In contrast, Dictyostelium, with a tail 10% longer than animal myosin, showed head-head interactions similar to animal myosin; however, the conformation of the folded tail was different. These results suggest that head-head interaction arose before the evolution of animals.
Sentinel-1 and COSMO-SkyMed image comparison on alpine environment for snow feature investigation

In this work, X and C band images acquired by COSMO-SkyMed (CSK) and Sentinel-1 (S1), respectively, on alpine environment have been compared for investigating snow characteristics. The specific capabilities of each sensor, involving also optical sensors (i. e., Landsat and Sentinel-2 satellites), have been exploited. Dense Media Radiative Transfer theory, with quasi-crystalline approximation (DMRT-QCA) was also considered, in order to simulate the snow feature behavior at X-band. Preliminary results show that the assimilation of different sensors returns more detailed information about the snow parameters in terms of spatial detail and physical parameter description.
Calcium-Dependent Structural Dynamics of a Spin-Labeled RyR Peptide Bound to Calmodulin.

Abstract We have used chemical synthesis, electron paramagnetic resonance (EPR), and circular dichroism to detect and analyze the structural dynamics of a ryanodine receptor (RyR) peptide bound to calmodulin (CaM). The skeletal muscle calcium release channel RyR1 is activated by Ca 2+ -free CaM and inhibited by Ca 2+ -bound CaM. To probe the structural mechanism for this regulation, wild-type RyRp and four spin-labeled derivatives were synthesized, each containing the nitroxide probe 2,2,6,6-tetramethyl-piperidine-1-oxyl-4-amino-4-carboxylic acid substituted for a single amino acid. In 2,2,6,6-tetramethyl-piperidine-1-oxyl-4-amino-4-carboxylic acid, the probe is rigidly and stereospecifically coupled to the α -carbon, enabling direct detection by EPR of peptide backbone structural dynamics. In the absence of CaM, circular dichroism indicates a complete lack of secondary structure, while 40% trifluoroethanol (TFE) induces >90% helicity and is unperturbed by the spin label. The EPR spectrum of each spin-labeled peptide indicates nanosecond dynamic disorder that is substantially reduced by TFE, but a significant gradient in dynamics is observed, decreasing from N- to C-terminus, both in the presence and absence of TFE. When bound to CaM, the probe nearest RyRp's N-terminus shows rapid rotational motion consistent with peptide backbone dynamics of a locally unfolded peptide, while the other three sites show substantial restriction of dynamics, consistent with helical folding. The two N-terminal sites, which bind to the C-lobe of CaM, do not show a significant Ca 2+ -dependence in mobility, while both C-terminal sites, which bind to the N-lobe of CaM, are significantly less mobile in the presence of bound Ca 2+ . These results support a model in which the interaction of RyR with CaM is nonuniform along the peptide, and the primary effect of Ca 2+ is to increase the interaction of the C-terminal portion of the peptide with the N-terminal lobe of CaM. These results provide, to our knowledge, new insight into the Ca 2+ -dependent regulation of RyR by CaM.
Managing a Complex Public Organization under Resource Dependency: The Case of the Washington Metropolitan Area Transit Authority (WMATA) Metrorail System

This article offers a timely and empirical case study of the effects of political influence from governing stakeholders on the management of a major inter-regional public transportation system in the greater Washington, DC area. It demonstrates the critical importance of intensive cooperation between federal, state, and local authorities for the sustainment and effective delivery of a vital public service, and documents the significant challenges for public managers charged with administering public organizations in an organizational environment characterized by resource dependence, principal-agent conflicts, and dysfunctional governance structures. Solutions recommended include institutional entrepreneurship, lobbying for stronger federal oversight, and greater use of strategic planning and strategic communications to shape public and legislator perspectives.
Altered Mental Status without Focal Neurological Deficit Is a Poor Predictor of True In-Hospital Stroke (P01.235)

OBJECTIVE: In-hospital “stroke alerts” called for altered mental status (AMS) without focal deficit are less likely to be an acute ischemic stroke. BACKGROUND: In-hospital “stroke alerts” are activated when a patient9s neurological status acutely deteriorates. Inpatient strokes represent an excellent potential opportunity for acute intervention and treatment, but over triaging mimics is a challenge. DESIGN/METHODS: We retrospectively analyzed prospectively collected inpatient stroke team alerts over a study period then collected information on presenting symptoms, signs, nursing floor unit, and final diagnoses. Patients on neurological floors were excluded. The final diagnoses of the patients as stroke or stroke-mimic were determined by consensus. Chi-square, t-test, and binary multiple logistic regression were used for analysis. RESULTS: Thirty-six of 93 (38.7%) stroke team calls were diagnosed with a stroke mimic. AMS was the leading reason for consultation in 33 of the 93 (35.5%) stroke alerts. Furthermore, 14 of the 33 calls (42.4%) for AMS were for patients without other focal neurological deficit. Only 1 of the 14 calls for AMS without focal deficit was diagnosed with acute/subacute stroke, three days post-cardiac arrest. The best predictors of stroke were a normal mental status (OR 5.88, p CONCLUSIONS: A normal mental status and a focal neurologic deficit best predict an acute in-hospital stroke. AMS is a frequent reason for activation of the stroke alert, however, AMS alone is a poor predictor of in-hospital stroke. Disclosure: Dr. George has nothing to disclose. Dr. Newey has nothing to disclose. Dr. Wisco has nothing to disclose. Dr. Gebel has received personal compensation for activities with Boehringer Ingelheim Pharmaceuticals as a speaker. Dr. Mays has received personal compensation for activities with GlaxoSmithKline, Allergen, Pfizer, and Zogenix/Astellas.
P-133 Hospice enabled dementia care: exploring a patient and carer led collaborative hub resource

‘Hospice enabled dementia care: [hospices as] key partners working with their local community and care economy to ensure people affected with dementia have access to optimum palliative care and support wherever they live and wherever they need it, regardless off anticipated prognosis’. St John’s Hospice is committed to reaching out to people affected by dementia and is developing a strategic action plan and partnerships to best support individuals with a dementia diagnosis and those closest to them. In order that the most effective assistance, information and care is made available, the hospice, together with NHS, social care, legal and university researcher colleagues has adopted a pilot model developed by a voluntary group, Lancashire Dementia Voices (LDV) within the region. In March 2016, this independent group of people living with dementia, launched a project to provide a ‘one-stop shop’ resource, regularly monthly and with themes and speakers to ensure up-to-date information, advice and support is readily available. St John’s Hospice and its partners see this ‘Hub’ resource as a potentially creative and collaborative development. Its first action is to seek the views of people living with dementia, through a ‘listening event’ to be held at the hospice in early June 2016. Information will be disseminated directly to individuals and their carers, identified through NHS services. It is also hoped that this event will generate interest for volunteers from the target group to join the multiple agencies in a steering group to determine the structure, venue, initial programme and regularity of the ‘Hub’ service. The hospice views this as part of its increasing community engagement and will review and evaluate its contribution to the project. By absorbing the views of people affected by dementia, and their carers, the hospice hopes to ensure delivery of dementia-friendly and effective inpatient, outpatient and home services.
Collaborative co-teaching models and specially designed instruction in secondary education: A new inclusive consultation model

Presented in this article are the rationale and construct of a new consultative teaching model for the inclusive instruction of students with learning disabilities in secondary schools. The inclusi...
Traditional Vs Gesture Based UAV Control

The purpose of this investigation was to assess user preferences for controlling an autonomous system. A comparison using a virtual environment (VE) was made between a joystick based, game controller and a gesture-based system using the leap motion controller. Command functions included basic flight maneuvers and switching between the operator and drone view. Comparisons were made between the control approaches using a representative quadcopter drone. The VE was designed to minimize the cognitive loading and focus on the flight control. It is a physics-based flight simulator built in Unity3D. Participants first spend time familiarizing themselves with the basic controls and vehicle response to command inputs. They then engaged in search missions. Data was gathered on time spent performing tasks, and post test interviews were conducted to uncover user preferences. Results indicate that while the gesture-based system has some benefits the joystick control is still preferred.
Atherosclerotic Vulnerable Plaques: Pathophysiology, Detection, and Treatment

Atherosclerotic plaque ulceration and fissuring lead to thrombosis and vasoconstriction. Local coagulation factors and blood components, in addition to plaque fissuring and ulceration, contribute to determining the development of thrombosis. Several different imaging procedures, including intravascular ultrasound, elastography, thermography, optical coherence tomography (OCT), magnetic resonance imaging (MRI), and computed tomography (CT) are being developed to detect vulnerable atherosclerotic plaques. Although it is variable among patient groups, perhaps 20% to 40% of patients with acute coronary artery syndromes have more than one vulnerable plaque, suggesting a relatively widespread inflammatory state within the coronary arteries.