cssi/SciSciGPT-SciSciNet huggingface dataset:
Urea inhibits hypertonicity-inducible TonEBP expression and action

Tonicity-responsive genes are regulated by the TonE enhancer element and the tonicity-responsive enhancer binding protein (TonEBP) transcription factor with which it interacts. Urea, a permeant sol...
From signal to pseudopod. How cells control cytoplasmic actin assembly.

Cet article de synthese examine les signaux associes aux changements de structure de la surface membranaire, qui dirigent la polymerisation d'actine et la formation de diverses protuberances membranaires tels que les pseudopodes, les microvillosites…
Building Institutional Capacity for College Access and Success: Implications for Enrollment Management

This article addresses how colleges and universities can address the enrollment management challenges with historically underrepresented student populations through a campus-wide capacity building approach. Implications from the cultural, economic, and academic achievement gaps will be addressed to inform strategies and initiatives for college student access and success.
Ontogenetic shifts in the diets of juvenile Chinook Salmon: new insight from stable isotopes and fatty acids

Variations in marine prey availability and nutritional quality can affect juvenile salmon growth and survival during early ocean residence. Salmon growth, and hence survival, may be related to the onset of piscivory, but there is limited knowledge on the interplay between the prey field, environment, and salmon ontogeny. Subyearling Chinook Salmon (Oncorhynchus tshawytscha) and their potential prey were sampled in coastal waters off Willapa Bay, USA to explore this issue. Three seasonal prey assemblages were identified, occurring in spring (May), early summer (June – July), and late summer (August – September). The onset of piscivory, based on salmon stomach contents, fatty acids, and stable isotopes occurred later in 2011 compared to 2012, and coincided with the appearance of Northern Anchovy (Engraulis mordax). Salmon fork length (FL) and carbon isotope values (δ13C) increased with a fatty acid biomarker for marine phytoplankton and decreased with a freshwater marker, indicating dietary carbon sources changed as salmon emigrated from the Columbia River. Salmon FL also increased with nitrogen isotope ratios (δ15N), trophic position, and a fatty acid marker for piscivory – a consequence of the ontogenetic shift in diet to fish. Salmon grew faster and obtained larger size and condition by September 2011 compared to 2012, which was related to inter-annual differences in ocean conditions and the duration over which Northern Anchovy were available. Our results support the idea that juvenile salmon growth depends on the onset and duration of piscivory, suggesting both of these factors may be important components of lifetime growth and fitness.
Nontraditional Career Opportunities for Pharmacists

The changing landscape of health care mirrors that of health-system pharmacy, with pharmacists' scope of practice and provider status being the most significant changes. This creates new roles and opportunities; many of these roles are considered to be nontraditional in today's practice. This article reviews some new roles for pharmacy leaders that provide different career options and pathways. Nontraditional career opportunities discussed include expanded consulting roles in pricing analytics and drug pricing programs (contracting, 340B programs), pharmacogenomics patient consult services and clinics, specialty drug pharmacies, and compounding pharmacy services. To continue to develop high-performing pharmacy departments, pharmacy directors should recognize these roles and ensure they are clearly defined and managed. With the advent of these nontraditional opportunities, pharmacy departments can further expand their ability to provide advanced patient-centered pharmacy services.
Evidence for the association of Hashimoto's thyroiditis with psoriasis: a cross-sectional retrospective study.

Background Current information indicates that psoriasis is a metabolic disorder with systemic manifestations. Reports have revealed an association between psoriasis and several chronic autoimmune disorders. For one of these disorders, Hashimoto's thyroiditis (HT), there are scarce, and relatively unconfirmed, reports of an association with psoriasis. We sought to determine if such an association is detectable in a large medical record data repository. Methods We searched one institution's electronic medical record data repository from January 2010 to December 2013. Patients were identified by ICD-9 codes (psoriasis: 696.0; 696.1, HT: 245.2). Only data from patients with laboratory-confirmed HT (anti-thyroid peroxidase [anti-TPO] antibodies; thyroglobulin antibodies; serum thyroid-stimulating hormone; and free T3) were eligible for inclusion. Logistic regression analysis was used to obtain an odds ratio (OR) to establish an association between psoriasis and HT. Stratified analyses were performed to test for confounding variable and effect modification. Results Medical records for 856,615 individuals with documented encounters between January 1, 2010, and December 31, 2013, were detected. A total of 9654 had a diagnosis of psoriasis, and 1745 had a diagnosis of HT. Of these, 41 subjects were diagnosed with both conditions. A significant association existed for psoriasis and HT, even after adjusting for confounding variables that included gender, age, psoriatic arthropathy, and the use of systemic anti-psoriatic agents (OR = 2.49; 95% CI 1.79–3.48; P < 0.0001). Conclusions This association has broad clinical impact and deserves further attention with regard to patient care, clinical research, and developmental therapeutics.
Lateral Flow Rapid Test for Accurate and Early Diagnosis of Scrub Typhus: A Febrile Illness of Historically Military Importance in the Pacific Rim.

ABSTRACTScrub typhus (ST) is an infection caused by Orientia tsutsugamushi. Historically, ST was ranked as the second most important arthropod-borne medical problem only behind malaria during World War II and the Vietnam War. The disease occurs mainly in Southeast Asia and has been shown to emerge and reemerge in new areas, implying the increased risk for U.S. military and civilian personnel deployed to these regions. ST can effectively be treated by doxycycline provided the diagnosis is made early, before the development of severe complications. Scrub Typhus Detect is a lateral flow rapid test based on a mixture of recombinant 56-kDa antigens with broad reactivity. The performance of this prototype product was evaluated against indirect immunofluorescence assay, the serological gold standard. Using 249 prospectively collected samples from Thailand, the sensitivity and specificity for IgM was found to be 100% and 92%, respectively, suggesting a high potential of this product for clinical use. This product...
Abstract 191: Identification of Adults With Congenital Heart Disease From Administrative Data

Introduction: With improved management, there are now more adults with congenital heart disease (ACHD) than children. However, long-term survival with moderate or severe ACHD remains limited, and there is relatively sparse literature on the intensity or quality of end-of-life care for these patients. The goal of this analysis is to examine the accuracy of administrative data for identifying patients who died with ACHD to facilitate study of care provided near the end of life. Methods: We created a list of ICD-9 and ICD-10 codes representing ACHD of moderate or great complexity. We performed a search for these codes in the electronic health record (EHR) of adults who received care 2010-2016 within our healthcare system. We used state death records to identify which of these patients died during the same timeframe. Manual EHR review was completed to evaluate performance of this search strategy. Identified patients were also compared to a list of patients seen in our ACHD clinic and known to have died during 2010-2016. Results: Using ICD data, 121 patients were identified, of which 66 actually had the moderate or greater complexity ACHD conditions by EHR review (positive predictive value, 0.55; 95% confidence interval 0.45, 0.63). EHR review confirmed 12 patients with Eisenmenger Syndrome, for which there is no specific ICD code. “Cyanosis+other” did not identify any of these, “VSD+other” (ventricular septal defect) identified 6, and there were 6 whose only ACHD code was VSD. Of the remaining 55 patients, 24 had ACHD not on the targeted list, largely due to coding error. In addition, despite being coded as having ACHD, 31 patients had no identified ACHD on EHR review. These misidentifications were attributed to coding error for 15 patients. Another 11 patients (35%) had acquired VSD due to myocardial infarction or endocarditis, for which there is no separate ICD code. Codes with the highest degree of error, incorrect more than 50% of the time, were those for congenitally corrected transposition, endocardial cushion defect, and hypoplastic left heart syndrome. The list of known deceased clinic patients included 21 with ACHD of interest. Only 1 of these was not identified by the ICD search, yielding a sensitivity for our list of ICD codes in this small sample of 0.95 (0.77,0.99). Conclusion: Use of administrative data to identify patients with ACHD of moderate or great complexity who have died had good sensitivity but suboptimal positive predictive value. Strategies to improve accuracy can be employed. Excluding patients who have codes for myocardial infarction or endocarditis in addition to VSD and using “VSD+other” as an additional proxy for Eisenmenger Syndrome are two examples. Administrative data is not ideal for identification of patients with ACHD of moderate or great complexity who have died, and manual EHR review is necessary to confirm these diagnoses.
Diabetes mellitus: Complex interplay between metformin, AKI and lactic acidosis.

Debate exists regarding the safety of metformin and the risk of metformin-associated lactic acidosis, particularly in the setting of kidney dysfunction. Data from two studies examining the interplay between metformin, acute kidney injury, and complications including lactic acidosis suggest that metformin should be used conservatively in patients with kidney dysfunction.
Sex Pheromone inPolistes fuscatus (Hymenoptera: Vespidae): Effect of age, caste and mating

Females of all ages, castes, and prior mating experiences elicited sexual behavior in males of the social waspPolistes fuscatus (F.). The venoms of workers, queens, uninseminated gynes more than 24 hours old, and inseminated gynes more than 14 days old were effective in stimulating male sexual behavior, and thus contained sex pheromone. The venom of gynes less than 15 hours old did not stimulate a significantly greater frequency of male sexual behavior than did the control.
PSYCHIATRIC DISORDER COMORBIDITY IN CHRONIC NEUROMUSCULOSKELETAL PAIN IN ATMA JAYA HOSPITAL

This study describe comorbid psychiatric disorder especially in depressive disorder, anxiety disorder and sleep disturbance in chronic neuromusculoskeletal pain patients. The aim of this study is to measure the prevalence of psychiatric comorbidity in choric neuromusculoskeletal pain. Cross sectional study with consecutive sampling method is used in this study. The data are collected in the neurology clinic in Atma Jaya Hospital, Jakarta between July – December 2015. Diagnostic and Statistical Manual of Mental Disorder (DSM) V criteria was used to diagnose the psychiatric condition. The data were obtain from 55 study samples, consist of 12 males (21,8%), 43 females (78,2%). Thirty of them are is more than or equal 60 years old (55%) and 25 are is less than 60 years old (45%). The most common is low back pain 30 patients (55%). Non-neuropathic pain 12 patients (22%), and neurophatic pain 43 patients (78%). The most common pain intensity is severe, Visual Analog Scale (VAS) is more than or equal 8 (43%). The most common psychiatric disorder is insomnia (20%), followed by anxiety and insomnia (16,3%), and anxiety (12,7%). Majority of chronic pain has psychiatric disoder comorbidity, coexisting condition should be considered in evaluation, diagnosis, and therapy. Chronic pain usually accompanied by psychiatric disorder, so thorough evaluation, diagnosis and therapy have to be fully addressed to achieve optimum functionality and good quality of life. Next study should collect samples from some hospitals and design the analitic study that can explain association between factors that can influence the comorbidity
Clinical outcomes and rates of aortic growth and reoperation after 1-stage repair of extensive chronic thoracic aortic dissection.

Abstract Objective The study objective was to analyze clinical outcomes, distal segmental aortic growth, and aortic reoperation rates after 1-stage open repair of extensive chronic thoracic aortic dissection via bilateral anterior thoracotomy. Methods Eighty patients underwent extensive 1-stage repair of chronic aortic dissection that included the ascending aorta, the entire aortic arch, and the varying lengths of the descending thoracic aorta. One half or more of the descending thoracic aorta was replaced in 62 (78%) of the 80 patients. Hospital mortality was 2.5% (2 patients). Stroke occurred in 1 patient (1.2%), spinal cord ischemic injury occurred in 1 patient (1.2%), and renal failure requiring long-term dialysis occurred in 2 patients (2.5%). Sixty-five of the 78 hospital survivors (83%) had serial imaging studies suitable for calculation of growth rates of the remaining dissected thoracic and abdominal aorta. Forty-seven patients were followed for more than 5 years, and 21 patients were followed for more than 10 years. Results The mean annual growth rate for the distal contiguous aorta was 1.7 mm/y. Forty aortas increased in diameter, 16 aortas remained unchanged, and 9 aortas decreased in diameter. Five patients required reoperation on the contiguous thoracic or abdominal aorta 8, 27, 34, 51, and 174 months postoperatively for progressive enlargement. Actuarial freedom from reoperation on the contiguous aorta at 5 and 10 years was 95.4% and 93%, respectively. Actuarial freedom from any aortic reoperation at 5 and 10 years was 89.2% and 84.4%, respectively. Actuarial survival for the entire cohort at 5 and 10 years was 76.4% and 52.6%, respectively, and survival free of any aortic operation was 68.6% and 43.9%, respectively. No patient whose cause of death was known died of aortic rupture. Conclusions Our extended experience with the 1-stage open procedure confirms its safety and durability for treatment of chronic aortic dissection with enlargement confined to the thoracic aorta. The procedure is associated with low operative risk and a low incidence of reoperation on the contiguous aorta. It represents a suitable alternative to the 2-stage, frozen elephant trunk, and hybrid procedures that are also used to treat this condition.
Nonparametric Methodology to Estimate Precipitating Ice from Multiple-Frequency Radar Reflectivity Observations

AbstractIn this study, a nonparametric method to estimate precipitating ice from multiple-frequency radar observations is investigated. The method does not require any assumptions regarding the dis...
Semigroups of Nonlinear Transformations in Banach Spaces

Publisher Summary This chapter discusses the semigroups of nonlinear transformations in banach spaces. It describes the notion of a generator of a nonlinear semigroup and the principle result giving sufficient conditions that an operator generates a semigroup.. The two classical notions concerning generators must be abandoned in the general nonlinear theory. The first is that of infinitesimal generator and the second is that generators are functions. The most difficult problem in the study of nonlinear semigroups has been that of determining whether a given S ɛ Qω (C) has a generator. The chapter reviews the results concerning existence of generators and discusses some results in special spaces
A facile copper(I)-catalyzed homo-coupling of indanone derivatives using diaziridinone under mild conditions

A novel and efficient Cu(i)-catalyzed homo-coupling of indanone derivatives using diaziridinone as an oxidant is described. A variety of 1,4-dicarbonyl compounds bearing two adjacent quaternary stereocenters were obtained in high yields with high diastereoselectivities via a base-free and operationally simple process under mild reaction conditions.
Decentralized Dynamic Task Allocation in Swarm Robotic Systems for Disaster Response.

Multiple robotic systems, working together, can provide important solutions to different real-world applications (e.g., disaster response), among which task allocation problems feature prominently. Very few existing decentralized multi-robotic task allocation (MRTA) methods simultaneously offer the following capabilities: consideration of task deadlines, consideration of robot range and task completion capacity limitations, and allowing asynchronous decision-making under dynamic task spaces. To provision these capabilities, this paper presents a computationally efficient algorithm that involves novel construction and matching of bipartite graphs. Its performance is tested on a multi-UAV flood response application.
Low to mid frequency whale noise compared to ambient noise

While the majority of ocean noise in the low and mid frequency range originates from the surface (shipping, wind wave noise), biologics are the predominant source of noise originating below the surface. Of the biologics, whales are one of the loudest and most frequent producers of vocalizations in the LF and MF bands. Their songs and clicks can be as loud as 236 dB re 1 μPa at 1 m and range in frequency from 10 Hz to well above 10 kHz. For a given frequency band, the ambient noise (excluding biologics) is typically greater than the cumulative effect of all contributing whales; however, as larger hydrophone arrays are built with increasing amounts of array gain this is no longer always the case. This work explores various spatial densities and source pressure levels (SPL) of whales to determine when a collection of whales becomes the dominant noise source on an array.
Deformable Mapping Method to Relate Lesions in Dedicated Breast CT Images to Those in Automated Breast Ultrasound and Digital Breast Tomosynthesis Images.

Abstract This work demonstrates the potential for using a deformable mapping method to register lesions between dedicated breast computed tomography (bCT) and both automated breast ultrasound (ABUS) and digital breast tomosynthesis (DBT) images (craniocaudal [CC] and mediolateral oblique [MLO] views). Two multi-modality breast phantoms with external fiducial markers attached were imaged by the three modalities. The DBT MLO view was excluded for the second phantom. The automated deformable mapping algorithm uses biomechanical modeling to determine corresponding lesions based on distances between their centers of mass (dCOM) in the deformed bCT model and the reference model (DBT or ABUS). For bCT to ABUS, the mean dCOM was 5.2 ± 2.6 mm. For bCT to DBT (CC), the mean dCOM was 5.1 ± 2.4 mm. For bCT to DBT (MLO), the mean dCOM was 4.7 ± 2.5 mm. This application could help improve a radiologist's efficiency and accuracy in breast lesion characterization, using multiple imaging modalities.
Evaluation of Germline Genetic Testing Criteria in a Hospital-Based Series of Women With Breast Cancer

PURPOSE To determine the sensitivity and specificity of genetic testing criteria for the detection of germline pathogenic variants in women with breast cancer.MATERIALS AND METHODSWomen with breast...
Host density and habitat structure influence host contact rates and Batrachochytrium salamandrivorans transmission

Batrachochytrium salamandrivorans (Bsal) is an emerging invasive pathogen that is highly pathogenic to salamander species. Modeling infection dynamics in this system can facilitate proactive efforts to mitigate this pathogen's impact on North American species. Given its widespread distribution and high abundance, the eastern newt (Notophthalmus viridescens) has the potential to significantly influence Bsal epidemiology. We designed experiments to 1) estimate contact rates given different host densities and habitat structure and 2) estimate the probability of transmission from infected to susceptible individuals. Using parameter estimates from data generated during these experiments, we modeled infection and disease outcomes for a population of newts using a system of differential equations. We found that host contact rates were density-dependent, and that adding habitat structure reduced contacts. The probability of Bsal transmission given contact between newts was very high (>90%) even at early stages of infection. Our simulations show rapid transmission of Bsal among individuals following pathogen introduction, with infection prevalence exceeding 90% within one month and >80% mortality of newts in three months. Estimates of basic reproductive rate (R0) of Bsal for eastern newts were 1.9 and 3.2 for complex and simple habitats, respectively. Although reducing host density and increasing habitat complexity might decrease transmission, these management strategies may be ineffective at stopping Bsal invasion in eastern newt populations due to this species' hyper-susceptibility.
The ‘Third Space’ in Luigi Capuana’s Gli americani di Ràbbato

Il romanzo di Luigi Capuana Gli americani di Rabbato (1912) suscita interesse per la sua trattazione di cio che Homi Bhabha definisce il ‘Third Space’, cioe il luogo di incontro di diverse culture che da forma ad un’identita ibrida. Il saggio illustra come Il romanzo mostri la creazione di soggetti di cultura ibrida sia a New York che a Rabbato in Sicilia, attraverso le vicissitudini della famiglia Lamanna. A New York, dove i rabbatani emigrano en masse sedotti dalle immagini dell’America – costruita dagli emigrazionisti come ‘terra della cuccagna’ – i siciliani, acquisiscono, per la prima volta dall’unita d’Italia, un’identita italiana, e, in un secondo tempo, anche una italo-americana. A Rabbato, invece, il ritorno degli emigrati – cambiati dall’esperienza americana, tanto da fargli acquisire il soprannome di ‘americani’ – finisce per influire sulla cultura e urbanistica locale, modificandole visibilmente. Il contributo sottolinea come Capuana, attraverso le parole del dottor Liardo, sembri auspicare la creazione di una classe sociale nuova, influenzata dallo spirito del self-made man acquisito dai rabbatani negli Stati Uniti, che possa sostituire la classe dei ‘galantuomini fannulloni’. In questa analisi si evidenzia come da Gli americani emerga cosi un’immagine dell’emigrazione sia come fenomeno ineluttabile per la Sicilia – che il progetto di unita nazionale aveva reso economicamente emarginata e subalterna al Nord – e per i siciliani, gia etichettati ‘razza maledetta’ dal discorso nazionale; e sia anche come fenomeno necessario per trasformare i siciliani in italiani, cioe per portare a termine il progetto nazionale che oltre a ‘fare l’Italia’ avrebbe dovuto ‘fare gli italiani’.
Sporting Community: Activism and Responsibility in Turbulent Times:

In the period since Television & New Media’s inception, most of my scholarly endeavors have focused on sports media as a critical everyday site for discussion and realization of “community” in an e...
Study of density profile dynamics in the tokamak fusion test reactor (TFTR)

A double pass multichannel far-infrared interferometer (Λ o = 119 μm) has been employed to measure electron density profile on the Tokamak Fusion Test Reactor (TFTR). This system provided valuable density information during a variety of plasma experiments. Density profile evolution during an adiabatic compression experiment was obtained and compared with TVTS results. Anomalous edge density behavior in “Marfe” discharges was observed. Also, density profile variation during solid pellet injection experiments has revealed several interesting features, such as peaked and hollow profiles.
Early adopters, firm survival, and environmental policy: dry cleaners in the South Coast Basin of California

This paper examines the relationship between the early adoption of new technologies, the probability of firm survival, and environmental regulations through a case study of dry cleaners in the Sout...
Triboelectricity and textile structures

Triboelectricity is a natural phenomenon with limited applications in the past. Wide research over the last decade introduced it mainly in energy harvesting and sensing. The use of textiles in trib...
Pediatric Mandible Fractures

Mandibular injuries in the growing patient are not uncommon, and the mature patient with permanent dentition can often be treated similarly to the adult patient. However, pediatric patients with primary dentition and mixed dentition can often be treated much more conservatively due to their healing capacity. It is imperative that the surgeon understand proper application of Risdon cables/wires to facilitate conservative treatment in the pediatric patient. Additionally, some fracture patterns are concerning for growth disturbance and require monitoring over ensuing years to ensure that no further intervention is necessary.
Understanding the triggers and communicative processes that constitute resilience in the context of migration to the United States

There are approximately 244 million migrants worldwide and 40 million migrants living in the US. These migrants face a myriad of stressors that they need to overcome. Framed by the communication th...
Investigating the relevance of major signaling pathways in cancer survival using a biologically meaningful deep learning model

Survival analysis is an important part of cancer studies. In addition to the existing Cox proportional hazards model, deep learning models have recently been proposed in survival prediction, which directly integrates multi-omics data of a large number of genes using the fully connected dense deep neural network layers, which are hard to interpret. On the other hand, cancer signaling pathways are important and interpretable concepts that define the signaling cascades regulating cancer development and drug resistance. Thus, it is important to investigate potential associations between patient survival and individual signaling pathways, which can help domain experts to understand deep learning models making specific predictions. In this exploratory study, we proposed to investigate the relevance and influence of a set of core cancer signaling pathways in the survival analysis of cancer patients. Specifically, we built a simplified and partially biologically meaningful deep neural network, DeepSigSurvNet, for survival prediction. In the model, the gene expression and copy number data of 1967 genes from 46 major signaling pathways were integrated in the model. We applied the model to four types of cancer and investigated the influence of the 46 signaling pathways in the cancers. Interestingly, the interpretable analysis identified the distinct patterns of these signaling pathways, which are helpful in understanding the relevance of signaling pathways in terms of their application to the prediction of cancer patients’ survival time. These highly relevant signaling pathways, when combined with other essential signaling pathways inhibitors, can be novel targets for drug and drug combination prediction to improve cancer patients’ survival time. The proposed DeepSigSurvNet model can facilitate the understanding of the implications of signaling pathways on cancer patients’ survival by integrating multi-omics data and clinical factors.
Quantifying the Sex-Race/Ethnicity-Specific Burden of Obesity on Incident Diabetes Mellitus in the United States, 2001 to 2016: MESA and NHANES.

Background Given the increasing prevalence of diabetes mellitus (DM) in the United States, estimating the effects of population‐level increases in obesity on incident DM has substantial implication...
Assessing the importance of nonlinearity for aircraft emissions' impact on O3 and PM2.5

Abstract In this study we utilize the Decoupled Direct Method (HDDM-3D) as implemented in the Community Multiscale Air Quality Model (CMAQ) to calculate first and second order sensitivity coefficients of O3 and PM2.5 concentrations with respect to aviation emissions during landing and takeoff (LTO) cycles at ten individual airports; five located in regions of attainment of O3 and PM2.5 NAAQS: Boston Logan (BOS), Kansas City (MCI), Raleigh-Durham (RDU), Seattle-Tacoma (SEA), and Tucson (TUS); and five airports in current nonattainment areas: Chicago O'Hare (ORD), Hartsfield- Jackson Atlanta (ATL), New York John F. Kennedy (JFK), Los Angeles (LAX), and Charlotte- Douglas (CLT). We utilize these coefficients in an attainment/nonattainment emission decrease/increase analysis to determine the importance of including second order sensitivity coefficients for quantifying O3 and PM2.5 concentration responses to LTO aircraft emission reductions near the airport. Sensitivity coefficients help to determine distinct chemical regimes, NOX-limited versus NOX-inhibited for the case of O3 formation, and NH3-rich versus NH3-poor for the case of PM2.5 formation. Overall, we find that NOX LTO emissions are the largest contributor to any potential nonlinearity in O3 and PM2.5 formation through LTO emissions. However, when utilizing Taylor series expansions to estimate O3 and PM2.5 concentration responses under LTO emission perturbation scenarios, differences in responses calculated using only first order coefficients and responses calculated using both first and second order coefficients were less than 1% for LTO emission perturbations less than 100%. Hence, we find from the results in this study that first order sensitivity coefficients are sufficient for constructing accurate LTO emissions perturbation scenarios. This study also demonstrates through the analyses performed, an illustration of how HDDM-based sensitivity calculations can be used to assess sector-specific impacts on attainment designations.
Groundwater Management in Chino Basin During the First 15 Years Under the Judgment

The early period of management under the Chino Basin Judgment featured some successes but a gradual build-up of frustrations. Provisions of the judgment covering pumping limitations and basin replenishment were put in place, and the first reallocation of pumping rights from agriculture to municipal and industrial use was carried out. As the 1980s went on, concerns arose among some parties about basin planning, the management of basin storage capacity, and groundwater quality degradation, prompting some reconsideration of what the overall basin management program should address. By the end of the decade, those concerns translated into a legal challenge by some Chino Basin parties to the ways in which the Judgment was being administered. That lawsuit both precipitated and foreshadowed a turning point in the basin governance and management regime.
Integrating Appreciative Advising into a Freshman Seminar Course

Higher education can help alleviate the nursing shortage. Yet, student attrition is a major barrier to graduating more nurses. At one university, overall freshman retention was 76.1% (1024) while major-related retention for freshman nursing students was even lower (64% [66]). In addition, program completion rates were deficient consecutively. Appreciative advising (AA) is an innovative framework for advising that seeks to discover, develop, and inspire students to reach their full potential (Hutson et al., 2014). The advisor-advisee relationship is cultivated until the student emerges as an independent being. The purpose of this comparative, quasi-experimental study was to determine if AA integrated into a freshman seminar course impacted academic major satisfaction. Quality advising, AA, and freshman seminar courses have individually demonstrated to improve retention rates, academic outcomes, and student satisfaction (Black et al., 2015; Harrell & Reglin, 2018; Hutson, 2013; Jaradat & Mustafa, 2017; NACADA, 2017; Sobel, 2018; What Works Clearinghouse, 2016). Nauta’s (2007) Academic Major Satisfaction Scale (AMSS) measured students’ satisfaction with their major before and after a series of AA sessions. Since major satisfaction is one of the most significant predictors of student retention (Hauser, 2014), students who are satisfied with the claimed major may be more likely to persist (Nauta, 2007). This one-group pretest/post-test study revealed nursing students’ (n = 81) academic major satisfaction improved at a statistically significant level (Z = –4.11, p < .001) with a medium effect (r = .32) after appreciative advising sessions.
Intel Realizes $25 Billion by Applying Advanced Analytics from Product Architecture Design Through Supply Chain Planning

Due to its scale, the complexity of its products and manufacturing processes, and the capital-intensive nature of the semiconductor business, efficient product architecture design integrated with s...
Tests of a Modified Reinforced Concrete Two-Way Slab

Tests to failure of a nine-panel two-way slab designed on the basis of a modified limit analysis are described. The behavior of the structure at various stages of loading is described in terms of deflections, reinforcement stresses, and cracks. Moments measured at the design sections are compared with the design moments. The flexural strength of the structure is computed using the yield-line theory.
Green Zones from Above and Below: A Retrospective and Cautionary Tale

This chapter acknowledges the antipodal nature of red and green zones while cautioning against casting green zones as a uniform response to human or ‘natural’ disturbances. Land allotments for gardening and farming are staple green zone behaviors and have deep historical roots. Carefully considered, these roots reveal that green zones originate from above, as social control, as well as from below to protect citizens and subjects against state misadventures, industrial dystopias, land enclosures, and environmental crises. The chapter seeks to show that green zone land policies can be top-down or bottom-up, are historically contingent, and will continue to evolve and hybridize as they have done in the past.
Social Dynamics of the North Central European Plains, 600–900s CE: A Model

In light of the data discussed in Chaps. 2 and 3, I argue that the Early Middle Ages phase 1 and the Early Middle Ages phase 2 societies of the North Central European Plain 500s–700s CE followed a polycentric scheme of self-governance and managed their resources in a primarily cooperative manner for about 200 years until a region-wide political multi-agent organization of the Tornow Interaction Sphere emerged in the late 700s and the 800s CE. Its collapse at the end of the 800s–early 900s CE piloted the emergence of a first-generation state-level polity in Greater Poland. The four stages of political organization in the region include: Participatory polycentric governance scheme of the Early Middle Ages phase 1, Manorial organization of the Early Middle Ages phase 2, Multi-agent political organization of the Early Middle Ages phase 3, and Pre-state-level complexity of the Early Middle Ages phase 4. Preferences toward collective actions did not disappear with the increase of political integrity and emergence of hierarchal structures, but were channeled into other forms of communal activities, while redistribution of incentives replaced reciprocity.
Nutritional Factors Affecting Fusarium Wilt Incidence and Severity

Fusarium wilt (Fusarium oxysporum Schlecht. f. sp. lycopersici (Sacc.) Snyder and Hansen) of tomato (Lycopersicon esculentum Mill.) was first reported in the United States in 1899 by E.F. Smith who said that the disease had put an end to the growing of tomatoes for the northern markets in certain areas of Florida. By 1920, the disease had become widespread and destructive throughout the southeast, midwest, and middle Atlantic states (Walker 1971).
Bacterial Induction of Cytokine Secretion in Pathogenesis of Airway Inflammation

Many bacterial species colonize mucosal surfaces, but relatively few are capable of evading the numerous host defenses to gain access to epithelial cells and cause disease. The clinical signs and symptoms of infection are attributed to the local accumulation of polymorphonuclear leukocytes (PMNs) and subsequent destruction of host tissue. The clinical signs and symptoms of airway infection in cystic fibrosis (CF) are mediated primarily by the influx of PMNs from the circulation to the site of infection in the airway. Bacteria in the airway lumen provide a potent stimulus for the epithelial expression of the proinflammatory cytokines, TNF-α, interleukin-1 (IL-1) β, and IL-8. The epithelial cells lining mucosal surfaces act as a peripheral component of the immune system, serving to both signal and respond to the threat of microbial pathogens. One of the major tenets of bacterial pathogenesis is the requirement for a specific ligand receptor interaction between the host and pathogen to initiate infection. The biological relevance of pilin- or flagellin-induced IL-8 expression in the pathogenesis of airway inflammation was further established in an animal model of respiratory tract infection. Pilin-mediated adherence to asialylated receptors, in addition to stimulating IL-8 expression, may also be a prerequisite for other types of Pseudomonas aeruginosa virulence. The organisms that elude mucociliary clearance, are resistant to antimicrobial peptide activity in the airways, and are not cleared by encounters with phagocytes, may reach the epithelial surface.
What matters most in leader selection? The role of personality and implicit leadership theories

Purpose – The purpose of this paper is to determine the primary basis upon which raters make decisions in the context of selection for formal leadership positions. Specifically, this paper examines the applicant’s personality, the rater’s personality, and the congruence between the applicant’s personality and the rater’s implicit leadership theories (ILTs) as predictors of interview scores. Design/methodology/approach – The hypotheses were tested via random coefficient modeling analyses using HLM software with the control variables included in Step 1 and the main effects entered in Step 2, and interaction effects in Step 3 as appropriate. Findings – Analyses suggest that both applicant and rater personality impact interview scores, but raters do not appear to select leaders on the basis of their conceptualization of an ideal leader. Research limitations/implications – The results suggest that raters may not consider their own ILTs when attempting to identify future leaders. Given this lack of a natural tendency toward selecting individuals that match one’s perceptions of an ideal leader, future research should focus on adapting current selection methods to leader selection and the development of new selection methods that are more valid. Practical implications – These findings suggest that current staffing practices may not encompass the most effective tools for selecting future leaders of the organization. These results highlight the importance of clarifying the outcome goals of the selection process in advance by giving raters a clear representation of the qualities and ideals that should be present in potential leaders. Originality/value – This study is among the first to examine the relationships between personality and ILTs in the context of a formal leadership selection process and makes a significant contribution to the literature by providing insight into the influence of both rater and applicant personality differences along with rater conceptualizations of ideal leadership in the context of formal leadership selection.
Sedative effects of three doses of romifidine in comparison with medetomidine in cats

Abstract Objective To compare the sedative effects of three doses of romifidine with one dose of medetomidine. Study design Prospective blinded experimental cross-over. Animals Five adult Domestic Short Hair cats. Methods Cats were administered romifidine at 80, 120 and 160 μg kg−1 or medetomidine at 20 μg kg−1 (M20) intramuscularly (IM). Sedative effects were assessed for 3 hours by summing the scores given to posture, auditory response, resistance to positioning, muscular relaxation, and response to noxious stimuli, giving a total sedation score (TS). The area under the curve (AUC) of TS ≥7 (the score considered as clinically useful sedation) was calculated. Times to stages of sedation were determined. Some physiological parameters were measured. Data to compare treatments were analysed by anova or Kruskal–Wallis test as relevant. Results All treatments gave a TS considered clinically useful. There were no significant differences between treatments for times to onset of sedation, maximum TS reached, or AUC. Differences between romifidine treatments for other sedation parameters were not significant but the time to maximum TS and to recovery was shortest in M20. Heart rate (HR) fell significantly with all treatments and, although with M20 it recovered at 65 minutes, it remained significantly depressed for 3 hours after all romifidine treatments. Most cats vomited, and/or hypersalivated after all treatments. Conclusions Doses of 80, 120 and 160 μg kg−1 romifidine IM produce sedation in cats which is similar to that following medetomidine 20 μg kg−1. Recovery from sedation and of physiological parameters was quickest after M20. Clinical relevance Doses of romifidine considerably lower than those investigated by previous authors give a clinically useful level of sedation, and their use might result in less side effects and a quicker recovery.
Neutron Scattering Studies of Interlayer Magnetic Coupling

This chapter contains a review of experimental methods and results of neutron scattering studies performed on AF and FM all-semiconductor superlattices. It demonstrates the efficiency of neutron diffraction methods in experimental studies of the interlayer coupling and contains a description of theoretical efforts to understand physical mechanisms of this coupling in semiconductor structures containing ferromagnetic and antiferromagnetic layers.
Sciatica due to piriformis pyomyositis. Report of a case.

Sciatica due to piriformis pyomyositis. Report of a case. W Chen; The Journal of Bone & Joint Surgery
New polar substituted-phenyl siloxane monomers and polymers for capillary gas chromatography

Abstract A series of polar substituted-phenylalkyl- (or phenoxyalkyl)dimethoxymethylsilanes has been prepared by the hydrosilylation of various phenyl-substituted alkenes. The disiloxane monomers were copolymerized with dimethoxydimethylsilane to prepare gums for testing as stationary phases for capillary column gas chromatography. Those phases which contained a phenoxypropyl unit were not stable at temperatures above 200°C. Phases having 3-phenylpropyl or 2-phenylethyl substituents were stable. The 4-methoxy- and 3,4-dimethoxyphenylethyl phases demonstrated different selectivities for polar solutes than could be obtained with other available stationary phases.
Oral Fluconazole as Suppressive Therapy of Disseminated Cryptococcosis in Patients with Acquired Immunodeficiency Syndrome

Purpose Because of the increasing numbers of patients with acquired immunodeficiency syndrome AIDS) who will require treatment for cryptococcosis and because of the problems associated with long-term administration of intravenous amphotericin B, an alternative therapeutic approach in the form of an efficacious and easily administered oral antifungal drug would be of great benefit. Fluconazole, a new triazole antifungal agent, represents such an alternative. We therefore conducted an open, non-randomized trial of oral fluconazole as maintenance suppressive therapy of disseminated cryptococcosis in patients with AIDS. Patients and methods Twenty patients with AIDS, 19 of whom had cryptococcal meningitis, were studied. Patients were followed for up to 21 months. All patients received amphotericin B as primary therapy, from 20 to 257 days prior to entry (500 to 5,080 mg total dose). Eight also received flucytosine. After administration of amphotericin B for acute disseminated cryptococcosis, and prior to initiation of fluconazole therapy, Cryptococcus neoformans was isolated from the cerebrospinal fluid (CSF) in two patients and from the blood in one patient. Fluconazole was given once daily, in doses of 50 to 200 mg/day. Results Following initiation of fluconazole, results of CSF and blood cultures continued to be negative, except for the CSF culture in one patient who had a relapse in the 32nd week of therapy. Fluconazole therapy has been successfully continued in nine patients, for a median of 11 months (nine to 21 months). Seven patients died; five had no evidence of active cryptococcosis at the time of death. Two patients had a relapse, although the CSF culture showed growth of the fungus in only one patient. One patient was lost to follow-up after five months of therapy and one was unevaluable. Fluconazole had to be discontinued in only one patient in whom thrombocytopenia developed, and then resolved when the drug was stopped. Conclusion We conclude that oral fluconazole represents a significant advance in the management of cryptococcal meningitis and should be useful in the long-term suppressive therapy of this opportunistic infection in patients with AIDS.
DNA assembler, an in vivo genetic method for rapid construction of biochemical pathways

The assembly of large recombinant DNA encoding a whole biochemical pathway or genome represents a significant challenge. Here, we report a new method, DNA assembler, which allows the assembly of an entire biochemical pathway in a single step via in vivo homologous recombination in Saccharomyces cerevisiae. We show that DNA assembler can rapidly assemble a functional D-xylose utilization pathway (~9kb DNA consisting of three genes), a functional zeaxanthin biosynthesis pathway (~11kb DNA consisting of five genes) and a functional combined D-xylose utilization and zeaxanthin biosynthesis pathway (~19kb consisting of eight genes) with high efficiencies (70–100%) either on a plasmid or on a yeast chromosome. As this new method only requires simple DNA preparation and one-step yeast transformation, it represents a powerful tool in the construction of biochemical pathways for synthetic biology, metabolic engineering and functional genomics studies.
A Phase-Locked AM Radio Receiver

The problems in the microminiaturization of frequency selective circuits have shown the lack of adaptability of the presently used superheterodyne system, particularly in the lower frequency band, to the integrated radio receiver. By using phase-lock technique, the incoming signal can be converted to baseband directly, eliminating the need for intermediate frequency tuned circuits. A preliminary study has been made of the feasibility and the practicality of using phase-lock technique in the consumer AM Tadio receiver. A two-channel, phase-locked receiver is discussed in this paper. It is shown that this system offers not only the advantages of microminiaturization, but in many aspects, better performance as well.
Iterative schemes and algorithms for adaptive grid generation in one dimension

Some iterative adaptive grid generators, developed by the author, are numerically explored in detail to assess their relative merits against conventional grid generators, based on a direct method of integration and interpolation. We find that some of these iterative adaptive grid generators are preferable to a direct method of integration and interpolation. In contrast with a direct method, appropriate use of these iterative adaptive grid generators produces adaptive grids with a smooth variation of the grid spacing ratio and resolution. All adaptive grid generators are a subclass of a more general iterative map. General features of this iterated map which are related to the function to be resolved are briefly discussed. The results obtained here supplements recent investigations on these adaptive grid generators by the author.