cssi/SciSciGPT-SciSciNet huggingface dataset:
TP73 allelic expression in human brain and allele frequencies in Alzheimer's disease.

The p73 protein, a paralogue of the p53 tumor suppressor, is essential for normal development and survival of neurons. TP73 is therefore of interest as a candidate gene for Alzheimer's disease (AD) susceptibility. TP73 mRNA is transcribed from three promoters, termed P1 – P3, and there is evidence for an additional complexity in its regulation, namely, a variable allelic expression bias in some human tissues. We utilized RT-PCR/RFLP and direct cDNA sequencing to measure allele-specific expression of TP73 mRNA, SNP genotyping to assess genetic associations with AD, and promoter-reporter assays to assess allele-specific TP73 promoter activity. Using a coding-neutral BanI polymorphism in TP73 exon 5 as an allelic marker, we found a pronounced allelic expression bias in one adult brain hippocampus, while 3 other brains (two adult; one fetal) showed approximately equal expression from both alleles. In a tri-ethnic elderly population of African-Americans, Caribbean Hispanics and Caucasians, a G/A single nucleotide polymorphism (SNP) at -386 in the TP73 P3 promoter was weakly but significantly associated with AD (crude O.R. for AD given any -386G allele 1.7; C.I. 1.2–2.5; after adjusting for age and education O.R. 1.5; C.I. 1.1–2.3, N= 1191). The frequency of the -386G allele varied by ethnicity and was highest in African-Americans and lowest in Caucasians. No significant differences in basal P3 promoter activity were detected comparing -386G vs. -386A promoter-luciferase constructs in human SK-NSH-N neuroblastoma cells. There is a reproducible allelic expression bias in mRNA expression from the TP73 gene in some, though not all, adult human brains, and inter-individual variation in regulatory sequences of the TP73 locus may affect susceptibility to AD. However, additional studies will be necessary to exclude genetic admixture as an alternative explanation for the observed associations.
Minority carrier lifetime and dark current measurements in mid-wavelength infrared InAs0.91Sb0.09 alloy nBn photodetectors

Carrier lifetime and dark current measurements are reported for a mid-wavelength infrared InAs0.91Sb0.09 alloy nBn photodetector. Minority carrier lifetimes are measured using a non-contact time-resolved microwave technique on unprocessed portions of the nBn wafer and the Auger recombination Bloch function parameter is determined to be |F1F2|=0.292. The measured lifetimes are also used to calculate the expected diffusion dark current of the nBn devices and are compared with the experimental dark current measured in processed photodetector pixels from the same wafer. Excellent agreement is found between the two, highlighting the important relationship between lifetimes and diffusion currents in nBn photodetectors.
The effect of sulfinpyrazone on platelet deposition on Dacron vascular grafts in man.

Abstract To determine if sulfinpyrazone inhibits platelet deposition on chronically implanted (>9 months) Dacron aortic bifurcation grafts in man, we performed indium-111 platelet imaging over 24 to 96 hours after labeled platelet injection in 10 males with grafts before and during sulfinpyrazone therapy (200 mg four times daily). Platelet accumulation was quantitated by a graft/blood ratio that compared indium-111 platelet image activity in the graft to platelet activity in well-counted whole blood. In addition, independent visual analysis compared platelet accumulation in the graft area to adjacent native arteries. By quantitative evaluation, sulfinpyrazone did not decrease the graft/blood ratio compared to baseline at 24 hours (3.2 ± 0.4 vs 3.3 ± 0.5, mean ± SEM), 48 hours (4.6 ± 0.6 vs 4.6 ± 0.9), 72 hours (6.8 ± 0.8 vs 6.7 ± 1.3), or 96 hours (9.7 ± 1.6 vs 9.7 ± 1.6) after labeled platelet injection. Visual interpretation also revealed no decrease in deposition in any patient during sulfinpyrazone therapy. We conclude that sulfinpyrazone does not inhibit platelet deposition on chronically implanted Dacron arterial graft surfaces in man. The techniques described provide a useful method of evaluating antithrombotic drug effects in patients with intravascular prosthetic materials.
Electrochemical Studies on the Corrosion of Steel Bar in Concrete in Chloride Environment

This paper deals with the influence of the steel-concrete interface quality on the steel bar corrosion. Electrochemical methods including linear polarization resistance (LPR) and electrochemical impedance spectroscopy (EIS) were comparatively used to monitor the corrosion process of reinforcing steel in cement mortar. Experimental results show that a good quality of steel-concrete interface can significantly delay the corrosion initiation and reduces the corrosion rate. The results highlight the reasonable correlation between the impedance response and the Rp values by LPR method, but the corrosion rates obtained by EIS are lower than those results of LPR.
An Arsenal of Words: Social Science and its Victims. A REVIEW ARTICLE

trio. Rohner's book is a cross-cultural study that addresses such questions as, 'Do humans everywhere respond uniformly to the withdrawal of parental warmth and affection? Do similar psychological, social, and environmental conditions induce parents the world over to behave toward their children in parallel ways? How is it possible methodologically, to determine if these things are true?' (Preface). Rohner asks these questions in the hope of arousing interest in the 'universalist question' of the 'nature of human nature.' Rodman's study, in contrast, presents a detailed ethnography of lower-class family life in Trinidad. However, his interests go beyond mere description; he offers an explanation of the data 'as a first step toward a general theoretical statement of lower-class family organization' (v). Hampden-Turner's concerns are of quite another kind. As a self-proclaimed 'radical,' he puzzles over the degree to which rhetoric in America has become detached from social reality. 'On the level of verbal argument the reformers always seem to be winning,' he declares, 'but nothing really happens' (xi). He is concerned with social inequality and injustice, and his book is intended as a contribution toward a restructuring of institutions so that they will be programmatically more responsive to America's emerging social consciousness. The theme of the book is that 'what is frustrating our attempts to turn rhetoric into reality is the lack of an adequate theoretical framework with which to fuse competing perspectives towards human development' (xi). The theme that ties these books together, and the focus of this review,
Ontogenetic diet shifts of age-0 smallmouth bass (Micropterus dolomieu Lacepède) in the New River, West Virginia, USA

Larval and juvenile smallmouth bass (Micropterus dolomieu Lacepede; 8.5–85.0 mm total length (TL)) were collected from 2 sites in the New River, West Virginia, in the late spring and early summer to document diet shifts during early ontogeny. The first foods of smallmouth bass (TL = 9 mm) were primarily Chironomidae and microcrustaceans (primarily Copepoda). Other aquatic insects, primarily Ephemeroptera, became more abundant in the stomachs as TL increased. A shift in the proportions and types of prey consumed began at approximately 15 mm TL and was primarily attributed to fin development and increased mouth size. Foraging success, measured by number of prey per stomach, stomach fullness, and average prey volume was lower for first-feeding smallmouth bass than for later life stages. Mouth width appeared to restrict the size of prey consumed by larval smallmouth bass, but the maximum prey width never approached the mouth width for fish longer than 35 mm TL.
Academic or Functional Life Skills? Using Behaviors Associated with Happiness to Guide Instruction for Students with Profound/Multiple Disabilities

The field of special education has begun to concentrate its efforts on developing objectives and procedural strategies that promote a positive quality of life for students with profound multiple disabilities, while determining which educational strategies are the most appropriate. A multielement design was used to compare the effects of two educational conditions, academic skills instruction and functional life skills instruction, on the quality of life indicators of four students with profound multiple disabilities. Results indicated that all four students demonstrated a greater number of behaviors associated with happiness while receiving academic skills instruction. Implications for current educational practices are addressed and directions for future research are discussed.
Delayed inhaled carbon monoxide mediates the regression of established neointimal lesions

Objective Intimal hyperplasia (IH) contributes to the failure of vascular interventions. While many investigational therapies inhibit the development of IH in animal models, few of these potential therapies can reverse established lesions. Inhaled carbon monoxide (CO) dramatically inhibits IH in both rats and pigs when given perioperatively. It also prevented the development of pulmonary arterial hypertension in rodents. Interestingly, CO could reverse pulmonary artery structural changes and right heart hemodynamic changes when administered after the establishment of pulmonary hypertension. Thus, we hypothesize that inhaled CO may mediate the regression of established neointimal lesions. Methods Rats underwent carotid artery balloon angioplasty injury. Carotid arteries were collected at 2 and 4 weeks after injury for morphometric analysis of the neointima. Another group was treated with inhaled CO (250 parts per million) for 1 hour daily from week 2 until week 4. Additional rats were sacrificed 3 days after initiating CO treatment, and the carotid arteries were examined for apoptosis by terminal deoxynucleotidyl transferase dUTP nick end-labeling, proliferation by Ki67 staining, and autophagy by microtubule-associated protein light chain 3 I/II staining. Results At 2 weeks following injury, sizable neointimal lesions had developed (intimal/media = 0.92 ± 0.22). By 4 weeks, lesion size remained stable (0.80 ± 0.09). Delayed inhaled CO treatment greatly reduced neointimal lesion size vs the 2- and 4-week control mice (0.38 ± 0.05; P P = .036). Proliferation was also dramatically reduced in the CO-treated animals (2.98 ± 1.55 vs 10.37 ± 2.80; P = .036). No difference in autophagy between control and CO-treated rats was detected. Conclusions Delayed administration of inhaled CO reduced established neointimal lesion size. This effect was mediated by the antiproliferative effect of CO on medial and intimal smooth muscle cells without increases in arterial wall apoptosis or autophagy. Future studies will examine additional time points to determine if there is temporal variation in the rates of apoptosis and autophagy.
Identification of acute toxicants in new bedford harbor sediments

New Bedford Harbor (NBH) is a marine Superfund site contaminated with high concentrations of polychlorinated biphenyls (PCBs), polycyclic aromatic hydrocarbons (PAHs), and metals. Experiments were conducted to determine the causal toxic agent(s) in pore waters from New Bedford Harbor sediments to amphipods and mysid shrimp. Chemical manipulations to characterize toxicity revealed that pore-water toxicity was organic in nature. Fractionation and subsequent mass spectral identification of peaks in the toxic fraction indicated that PCBs, PAHs, and unknown compounds were present. Comparisons of PAH LC50s and PAH concentrations in this fraction indicated that the toxicity was not due to PAHs because the PAH concentrations were much lower than the reported PAH LC50s. One unknown peak was positively identified as bis(2-ethylhexyl) phthalate, and the other tentatively identified as pyrazole. Toxicity tests and comparison of toxicity in the blank and toxic fractions eliminated the two “unknowns” as toxic causal agents. We determined the range of PCB LC50s to fall between 10 and 110 ppb for Mysidopsis bahia and Ampelisca abdita. Concentrations of PCBs for the toxic fractions ranged from 12 to 27 ppb. This range falls within our observed PCB LC50s for M. bahia and A. abdita. Based upon these PCB concentrations, we concluded that PCBs were the acute toxic agents in NBH pore waters. Other compounds in the toxic fractions, or compounds that coeluted and were undistinguished from PCBs had minor contributions to the measured toxicity.
Reactions of Laser-Ablated Ni, Pd, and Pt Atoms with Carbon Monoxide: Matrix Infrared Spectra and Density Functional Calculations on M(CO)n (n = 1−4), M(CO)n- (n = 1−3), and M(CO)n+ (n = 1−2), (M = Ni, Pd, Pt)

Laser-ablated Ni, Pd, and Pt atoms have been reacted with CO molecules followed by condensation in excess neon at 4 K. Besides the neutral metal carbonyl species, metal carbonyl anions [M(CO)n- (n ...
Effects of β-carboline-ethyl ester on plasma corticosterone--A parallel with antagonist-precipitated diazepam withdrawal

Abstract Diazepam has been shown to produce physical dependence based on observations of behavioral stimulation or, in our laboratory, by increases in plasma corticosterone (CS) during antagonist-precipitated withdrawal. The behavioral excitation appears similar to that observed following the administration of β-carboline esters--agents reported to interact with benzodiazepine receptors and termed “inverse agonists”. The focus of the present study is to correlate the occurrence of changes in CS with behavioral excitation previously observed by others. Further, these studies are designed to show a parallel between the manifestations of benzodiazepine withdrawal and the pharmacologic effects of β-carboline ethyl ester. Experiments were done in conscious unrestrained male Sprague-Dawley rats, with chronic i.v. catheters, using sound-attenuated one-way vision boxes. These studies compared the hormonal and behavioral changes induced by β-carboline ethyl ester (βCCE) with CGS-8216-precipitated withdrawal in rats treated with diazepam for 8 days. Rats treated chronically with diazepam (5 mg/kg/day), showed a significant increase in plasma (CS) following CGS-8216. Behavioral abstinence scores were also significantly elevated. βCCE (0.5–5.0 mg/kg) showed a significant dose-related increase in plasma CS. Behavioral scores were also increased at doses of 0.5 and 2.0 mg/kg. βCCE-induced plasma CS increases were antagonized by CGS-8216 at doses of 1.0 and 2.0 mg/kg but not by 0.5 mg/kg. In animals chronically treated with diazepam, βCCE evoked a more prolonged plasma CS elevation than in vehicle-treated animals suggesting a dual agonist/antagonist effect. These data suggest a parallel between CS elevations and behavioral effects during withdrawal as well as similarities between the action of βCCE and the manifestations of this withdrawal.
JS-K, a novel non-ionic diazeniumdiolate derivative, inhibits Hep 3B hepatoma cell growth and induces c-Jun phosphorylation via multiple MAP kinase pathways

JS-K, a non-ionic diazeniumdiolate derivative, is capable of arylating nucleophiles and spontaneously generating nitric oxide (NO) at physiological pH. This recently synthesized low molecular weight compound is shown here to be an inhibitor of cell growth with concomitant activation of mitogen-activated protein kinase (MAPK) members ERK, JNK, and p38 and their downstream effectors c-Jun and AP-1. Inhibitors of these MAPK pathways abrogated the growth inhibitory actions of JS-K. In addition to the well-described actions of JNK as a kinase for c-Jun, we show that c-Jun is also an ERK target. Furthermore, JS-K generated NO in culture and NO inhibitors antagonized both MAPK induction and the growth inhibitory effects of JS-K. These results suggest two possible mechanisms for the mediation of JS-K growth inhibitory actions, namely NO-induction of MAPK pathway constituents as well as possible arylation reactions. The data support the idea that prolonged MAPK activation by JS-K action is important in mediating its growth-inhibitory actions. JS-K thus represents a promising platform for novel growth inhibitory analog synthesis.
Nonrigid motion analysis using nonlinear finite element modeling

In this paper, we consider the problem of tracking elastic objects with known material properties. That corresponds to utilization of specific a priori knowledge in nonrigid motion analysis. We propose the utilization of nonlinear finite element methods (FEM) for point correspondence recovery. We deal with range data, i.e., assume that surface points before and after motion are available from the sensing system. Nonlinear FEM not only allows for modeling of nonlinear material properties but also for large deformation between consecutive time frames (which are main limitations of widely utilized linear FEM). We propose a new algorithm for the point correspondence recovery in nonrigid motion using assumptions of known material properties and single (but not known) force applied to the object. Simulations and experimental results demonstrate the performance of the proposed algorithm.© (1993) COPYRIGHT SPIE--The International Society for Optical Engineering. Downloading of the abstract is permitted for personal use only.
An Overview of the NASA FAP Hypersonics Project Airbreathing Propulsion Research

The propulsion research portfolio of the National Aeronautics and Space Administration Fundamental Aeronautics Program Hypersonics Project encompasses a significant number of technical tasks that are aligned to achieve mastery and intellectual stewardship of the core competencies in the hypersonic-flight regime. An overall coordinated programmatic and technical effort has been structured to advance the state-of-the-art, via both experimental and analytical efforts. A subset of the entire hypersonics propulsion research portfolio is presented in this overview paper. To this end, two programmatic research disciplines are discussed; namely, (1) the Propulsion Discipline, including three associated research elements: the X-51A partnership, the HIFiRE-2 partnership, and the Durable Combustor Rig, and (2) the Turbine-Based Combine Cycle Discipline, including three associated research elements: the Combined Cycle Engine Large Scale Inlet Mode Transition Experiment, the small-scale Inlet Mode Transition Experiment, and the High-Mach Fan Rig.
A role of the Lowe syndrome protein OCRL in early steps of the endocytic pathway

Summary Mutations in the inositol 5-phosphatase OCRL are responsible for Lowe syndrome, whose manifestations include mental retardation and renal Fanconi syndrome. OCRL has been implicated in membrane trafficking, but disease mechanisms remain unclear. We show that OCRL visits late-stage, endocytic clathrin-coated pits and binds the Rab5 effector APPL1 on peripheral early endosomes. The interaction with APPL1, which is mediated by the ASH-RhoGAP-like domains of OCRL and is abolished by disease mutations, provides a link to protein networks implicated in the reabsorptive function of the kidney and in the trafficking and signaling of growth factor receptors in the brain. Crystallographic studies reveal a role of the ASH-RhoGAP-like domains in positioning the phosphatase domain at the membrane interface and a clathrin box protruding from the RhoGAP-like domain. Our results support a role of OCRL in the early endocytic pathway, consistent with the predominant localization of its preferred substrates, PI(4,5)P 2 and PI(3,4,5)P 3 , at the cell surface.
Cloning, characterization and functional expression of a phospholipase Dα cDNA from tomato fruit

Phospholipase D (PLD; EC 3.1.4.4) initiates phospholipid (PL) catabolism in plant cells and is also involved in signal transduction and retailoring of membrane PL. Phosphatidic acid (PA), the product of PLD hydrolysis of PL, increases in pericarp tissue during ripening of tomato (Lycopersicon esculentum Mill.) fruit, suggesting that increased PLD activity may be involved in loss of membrane function associated with ripening. However, a recent report showed a decline in soluble PLD activity in both normal and nonripening mutant fruit over the span that encompasses full ripening. To directly assess the role of PLD in tomato ripening, we have initiated a molecular genetic approach. Using a PLDalpha cDNA from castor bean as a probe, a PLDalpha cDNA (LEPLD2) was isolated from a tomato fruit library. It has an open reading frame of 2 421 nucleotides, predicted to encode a polypeptide of 807 amino acids, with a molecular mass of 91.9 kDa. These values are close to those of PLDalphas from 11 plant species and LEPLD2 has >/=73% nucleotide sequence identity with PLDalpha cDNAs from castor bean and tobacco, as well as another tomato cDNA. LEPLD2 transcript was detected in all tissues of the tomato plant by RNA gel-blot analysis. Levels were very low in roots, low in stems, moderate in leaves, high in flowers and increased in fruit during development and ripening. Expression of LEPLD2 in Escherichia coli yielded phosphatidylcholine-hydrolyzing enzyme, and cells transformed with a pFLAG-MAC vector construct produced a FLAG-PLDalpha fusion protein that migrated close to the calculated 94 kDa on sodium dodecyl sulfate-polyacrylamide gel electrophoresis.
Research Mentorship in Counselor Education

The purpose of this national survey was to determine whether pretenured counselor educators receive research mentorship, and if so, what instructional and relational factors occur within that relationship. Pretenured counselor educators in counselor education programs accredited by the Council for Accreditation of Counseling and Related Educational Programs were surveyed (N = 269). The 139 respondents (51.7% response rate) indicated that most (n / 107) pretenured counselor educators receive research mentorship. The relationship(s), most often described as cooperative (n / 84) and open (n / 70), focused primarily on navigation of promotion and tenure (n / 87) and generating refereed publications (n / 95) and presentations (n / 72).
SU‐E‐T‐248: An Extended Generalized Equivalent Uniform Dose Accounting for Dose‐Range Dependency of Radio‐Biological Parameters

Purpose: Introducing an extended, phenomenological, generalized equivalent uniform dose (eEUD) that incorporates multiple volume‐effect parameters for different dose‐ranges. Methods: The generalized EUD (gEUD) was introduced as an estimate of the EUD that incorporates a single, tissue‐specific parameter ‐ the volume‐effect‐parameter (VEP) ‘a’. As a purely phenomenological concept, its radio‐biological equivalency to a given inhomogeneous dose distribution is not a priori clear and mechanistic models based on radio‐biological parameters are assumed to better resemble the underlying biology. However, for normal organs mechanistic models are hard to derive, since the structural organization of the tissue plays a significant role. Consequently, phenomenological approaches might be especially useful in order to describe dose‐response for normal tissues. However, the single parameter used to estimate the gEUD may not suffice in accurately representing more complex biological effects that have been discussed in the literature. For instance, radio‐biological parameters and hence the effects of fractionation are known to be dose‐range dependent. Therefore, we propose an extended phenomenological eEUD formula that incorporates multiple VEPs accounting for dose‐range dependency. Results: The eEUD introduced is a piecewise polynomial expansion of the gEUD formula. In general, it allows for an arbitrary number of VEPs, each valid for a certain dose‐range. We proved that the formula fulfills required mathematical and physical criteria such as invertibility of the underlying dose‐effect and continuity in dose. Furthermore, it contains the gEUD as a special case, if all VEPs are equal to ‘a’ from the gEUD model. Conclusion: The eEUD is a concept that expands the gEUD such that it can theoretically represent dose‐range dependent effects. Its practicality, however, remains to be shown. As a next step, this will be done by estimating the eEUD from patient data using maximum‐likelihood based NTCP modelling in the same way it is commonly done for the gEUD.
Connective tissue: a metabolic Entity?

The heart is composed of parenchyma (cardiac myocytes) and stroma (connective tissue). Stroma is presumed inert and therefore little attention has been paid to its regulation. Contrary to this notion, evidence presented here raises the possibility that connective tissue is a metabolically active entity capable of regulating peptide hormone generation and degradation acid these hormones, in autocrine manner, regulate collagen turnover. This concept has evolved from quantitative in vitro autoradiography (using 125I-351A), which localized angiotensin converting enzyme (ACE) binding density within the heart. A heterogeneous distribution was found. Low-density ACE is present within atria ventricles. At sites of high collagen turnover, such as valve leaflets, adventitia and fibrous tissue of diverse etiologic origins, ACE binding density is high and independent of circulating angiotensin II. ACE-producing cells at these sites. identified by monoclonal ACE antibody and 125I-351A binding, include fibroblast-like alpha actin-containing cells that express the transcript for type I collagen (in situ hybridization). Receptor-ligand binding for angiotensin II and bradykinin is found in fibrous tissue, where these peptides may provide for a reciprocal regulation of fibroblast collagen turnover. Connective tissue formation is attenuated by ACE inhibition or antagonism of type I angiotensin II receptor. Thus, emerging evidence raises the possibility that stroma and its cellular constituents is a dynamic, metabolically active entity regulating its own peptide hormone composition and, in turn, its turnover of fibrillar collagen.
PsaC Subunit of Photosystem I Is Oriented with Iron-Sulfur Cluster FB as the Immediate Electron Donor to Ferredoxin and Flavodoxin

The PsaC subunit of photosystem I (PS I) binds two [4Fe-4S] clusters, F(A) and F(B), functioning as electron carriers between F(X) and soluble ferredoxin. To resolve the issue whether F(A) or F(B) is proximal to F(X), we used single-turnover flashes to promote step-by-step electron transfer between electron carriers in control (both F(A) and F(B) present) and HgCl2-treated (F(B)-less) PS I complexes from Synechococcus sp. PCC 6301 and analyzed the kinetics of P700+ reduction by monitoring the absorbance changes at 832 nm in the presence of a fast electron donor (phenazine methosulfate (PMS)). In control PS I complexes exogenously added ferredoxin, or flavodoxin could be photoreduced on each flash, thus allowing P700+ to be reduced from PMS. In F(B)-less complexes, both in the presence and in the absence of ferredoxin or flavodoxin, P700+ was reduced from PMS only on the first flash and was reduced from F(X)- on the following flashes, indicating lack of electron transfer to ferredoxin or flavodoxin. In the F(B)-less complexes, a normal level of P700 photooxidation was detected accompanied by a high yield of charge recombination between P700+ and F(A)- in the presence of a slow donor, 2,6-dichlorophenol-indophenol. This recombination remained the only pathway of F(A)- reoxidation in the presence of added ferredoxin, consistent with the lack of forward electron transfer. F(A)- could be reoxidized by methyl viologen in F(B)-less PS I complexes, although at a concentration two orders of magnitude higher than is required in wild-type PS I complexes, thus implying the presence of a diffusion barrier. The inhibition of electron transfer to ferredoxin and flavodoxin was completely reversed after reconstituting the F(B) cluster. Using rate versus distance estimates for electron transfer rates from F(X) to ferredoxin for two possible orientations of PsaC, we conclude that the kinetic data are best compatible with PsaC being oriented with F(A) as the cluster proximal to F(X) and F(B) as the distal cluster that donates electrons to ferredoxin.
Prediction and Derivation of the Higgs Boson from the Neutron and Properties of Hydrogen Demonstrating Relationships with Planck's Time, the Down Quark, and the Fine Structure Constant

A high accuracy Higgs boson, H0, is an important physical constant. The Higgs boson is associated with the property of mass related to broken symmetry in the Standard Model. The H0 mass cannot be derived by the Standard Model. The goal of this work is to derive and predict the mass of H0 from the subatomic data of the frequency equivalents of the neutron, electron, Bohr radius, and the ionization energy of hydrogen. H0’s close relationships to the fine structure constant, α, the down quark, and Planck time, tP are demonstrated. The methods of the harmonic neutron hypothesis introduced in 2009 were utilized. It assumes that the fundamental constants as frequency equivalents represent a classic unified harmonic system where each physical constant is associated with a classic harmonic integer fraction. It has been demonstrated that the sum exponent of a harmonic integer fraction, and a small derived linear δ value of the annhilation frequency of the neutron, vn, 2.2718591 × 1023 Hz, (vns) as a dimensionless coupling constant represent many physical constants as frequency equivalents. This is a natural unit system. The harmonic integer fraction series is 1/±n, and 1 ± 1/n for n equals 1 to ∞. The H0 is empirically and logically is associated with harmonic fractions, 1/11 and 1 + 1/11. α-1 is associated with 11. α-1 is a free space scaling constant for the electromagnetic force so it is logical that 11 should also have a pair, but for a free space mass constant. Also there should be a harmonic faction pair for the down quark, 1 - 1/11, just as there is pairing of the up quark, 1 - 1/10, and top quark, 1 + 1/10. The harmonic neutron hypothesis has published a method deriving a high accuracy Planck time, tP from the same limited subatomic data. The δ line for H0 should be closely associated with tP since they both are related to mass. The preferred derived value related to tP2 is 125.596808 GeV/c2. A less attractive derived value is 125.120961 GeV/c2 from the weak force factors only. The experimental CMS and Atlas value ranges are 125.03+0.26+0.13-0.27-0.15 and 125.36±0.37±0.18 GeV/c2. Empirically the H0 δ line is closely related to the same factors of the tP δ line, but with inverse sign of the slope. The H0 completes the paring of a free space constant for mass, the down quark, and an inverse sign δ line factors with tP. It is possible to accurately derive the mass of H0 from subatomic physical data. The model demonstrates that H0 is closely associated with α, the down quark, and tP. This prediction can be scrutinized in the future to see if it is accurate. The model has already published accurate predictions of the masses of the quarks.
The Population Value Of Quality Indicator Reporting: A Framework For Prioritizing Health Care Performance Measures

The Agency for Healthcare Research and Quality (AHRQ) National Healthcare Quality and Disparities Reports contain more than 250 quality indicators, such as whether a patient with a suspected heart attack received an aspirin. The Department of Health and Human Services National Quality Measures Clearinghouse identifies more than 2,100 such indicators. Because resources for making quality improvements are limited, there is a need to prioritize among these indicators. We propose an approach to assess how reporting specific quality indicators would change care to improve the length and quality of life of the US population. Using thirteen AHRQ quality indicators with readily available data on the benefits of indicator reporting, we found that seven of them account for 93 percent of total benefits, while the remaining six account for only 7 percent of total benefits. Use of a framework such as this could focus resources on indicators having the greatest expected impact on population health.
A stepwise procedure to test contractility and susceptibility to injury for the rodent quadriceps muscle.

In patients with muscle injury or muscle disease, assessment of muscle damage is typically limited to clinical signs, such as tenderness, strength, range of motion, and more recently, imaging studies. Biological markers can also be used in measuring muscle injury, such as increased creatine kinase levels in the blood, but these are not always correlated with loss in muscle function (i.e. loss of force production). This is even true of histological findings from animals, which provide a “direct measure” of damage, but do not account for loss of function. The most comprehensive measure of the overall health of the muscle is contractile force. To date, animal models testing contractile force have been limited to the muscle groups moving the ankle. Here we describe an in vivo animal model for the quadriceps, with abilities to measure torque, produce a reliable muscle injury, and follow muscle recovery within the same animal over time. We also describe a second model used for direct measurement of force from an isolated quadriceps muscle in situ .
The magnetic circular dichroism spectrum of the halogen molecules I2, Br2, Cl2. Resolution of overlapping continua

Abstract The magnetic circular dichroism spectra of the halogen molecules I 2 , Br 2 and Cl 2 were investigated in solution and in the gas phase. The spectral region studied was the visible and near ultraviolet (800-250 nm). The MCD spectra were interpreted successfully in terms of the transitions to the states 3 Π 1u , 3 Π 0 + u , and 1 Π u . The interpretation presented is supported by a theoretical calculation of MCD parameters which successfully account for the observations. The major result is the resolution of the continuous absorption into the contributions due to 3 Π 0 + u and 1 Π u .
Paraventricular nucleus lesions exaggerate dietary obesity but block photoperiod-induced weight gains and suspension of estrous cyclicity in Syrian hamsters

Abstract Lesions of the paraventricular nucleus (PVN) of the hypothalamus block short photoperiod-induced testicular regression in Syrian hamsters. We examined the effects of PVN or sham lesions on the short photoperiod-induced increases in body weight and adiposity in female Syrian hamsters. PVN lesions did not affect body weight when hamsters were housed in a long photoperiod (LD, 16:8) and fed Purina laboratory rodent chow (No. 5001). However, when fed a high-fat diet both groups gained weight, and the hamsters with PVN lesions gained approximately twice as much as the sham-operated controls. When the hamsters were exposed to a short photoperiod (LD, 8:16), only the hamsters with sham lesions displayed the typical increase in body weight. No further increase in body weight or parametrial fat pad weight was seen when the hamsters with PVN lesions were exposed to the short photoperiod. The lack of a short photoperiod-induced increase in body weight gain in hamsters with PVN lesions seems unlikely to be due to a “ceiling effect” on body weight gain because we have routinely observed neurally intact, melatonin-treated female Syrian hamsters with body weight in excess of 250 g. Finally, the short photoperiod interrupted estrous cyclicity in sham-lesioned hamsters but not in those with PVN lesions. Thus, PVN lesions exaggerate dietary obesity but prevent short photoperiod-induced weight gains and vaginal acyclicity in female Syrian hamsters.
Effect of particle dimension on biocompatibility of carbon nanomaterials

With various emerging applications ranging from medicine to materials and electronics, the risk of exposure to nanomaterials is rapidly increasing. Several routes of exposure to nanomaterials exist; the most important being dermal contact and inhalation. In this dermal toxicity study, the cellular effects of carbon-based materials with diameters ranging from micro- to nano-dimension were investigated using mouse keratinocytes (HEL-30). The carbon materials tested included carbon fibers (CF; 10 μm diameter), carbon nanofibers (CNF; 100 nm diameter), multi-walled carbon nanotubes (MWCNT; 10 nm diameter), and single-walled carbon nanotubes (SWCNT; 1 nm diameter). CF and CNF did not significantly affect cell viability; however, MWCNT and SWCNT reduced cell viability in a time-dependent manner up to 48 h, with full recovery of mitochondrial function by the 72 h time point. After a 24 h exposure, cells exposed to MWCNT produced up to 3-fold higher increase in reactive oxygen species than those exposed to SWCNT. The results of this study suggest that high-aspect ratio carbon material toxicity is dependent on dimension and composition.
The indications for interbody fusion cages in the treatment of spondylolisthesis: analysis of 120 cases.

Study design This study retrospectively examines outcomes of unilateral transforaminal lumbar interbody fusion (TLIF) with posterior fixation using anterior carbon fiber cages and 360 degrees fusion in spondylolisthesis. Objectives The goals were to examine the outcomes and perioperative complications of using anterior column support in the treatment of various types of spondylolisthesis. Summary of background data In 2000, Brantigan et al reported the Brantigan interbody fusion cage used as a posterior lumbar interbody fusion in the US IDE clinical trial. This is the largest series to date of TLIF cages specifically used in the treatment of spondylolisthesis. Methods A comprehensive long-term follow-up study was conducted to evaluate the fusion success and morbidity following implantation with an anterior column support and posterior pedicle screw fixation. The 120 patients with spondylolisthesis were comprised by 11 cases, dysplastic; 58 cases, degenerative; and 51 cases, isthmic-acquired spondylolisthesis. Anterior column support was either a rectangular carbon fiber/PEEK device or a cylindrical carbon fiber/PEEK device. Twenty-eight cases (23%) were revisions. Results There were no pseudarthrosis, instrumentation failures, or significant subsidence at the TLIF level. The disc space height and foraminal height were restored as part of the surgical procedure. Disc height, as measured from the posterior edge of the superior vertebral body, increased from a mean of 5.6 mm before surgery to a mean of 9.3 mm after surgery. Although reduction of the slip was not the primary goal during the surgical procedure for the 120 cases with spondylolisthesis (isthmic-acquired = 51, degenerative = 58, and dysplastic = 11), the 23% slip reduction achieved at surgery was maintained at follow-up. Mean operative time was 143 +/- 33 minutes (range, 70-255 minutes) for all cases. Mean blood loss was 724 +/- 431 mL (range, 300-2,500 mL). There were seven incidental durotomies and three infections. One patient with Grade I degenerative spondylolisthesis required revision of the carbon fiber cage for posterior migration secondary to a traumatic event 3 months after surgery. Fusion success was 98% using the criteriaof Lenke for the posterior fusion and Brantigan and Steffee for the TLIF graft incorporation. Conclusions Interbody cages in spondylolisthesis are useful to increase neuroforaminal height, to facilitate reduction, and to improve the chances of achieving a successful 360 degrees fusion.
Discussion on “Sequential Estimation for Time Series Models” by T. N. Sriram and Ross Iaci

Abstract Among other issues, Sriram and Iaci (2014) have elegantly drawn attention to the notion of “negative regret” for a number of interesting sequential minimum risk point estimation problems under a time series model. We briefly lay down our thoughts and understanding with regard to possible negative regret in some of the point estimation problems.
Measurement of (n,α) reactions on 147Sm and 149Sm using a lead slowing-down spectrometer

Abstract The lead slowing-down spectrometer (LSDS) at Rensselaer Polytechnic Institute (RPI) was used to extend previous measurements of the (n,α) cross section on 147Sm and perform measurements on 149Sm over the energy range 0.1 eV–10 keV. A compensated detector based on passivated implanted planar silicon (PIPS) detectors was constructed. Signals from two detectors were combined in opposite polarity and digitized providing a single detector capable of discriminating against capture γ's and “γ-flash” while preserving the discrete signals produced by α events and providing a simultaneous background measurement. Extrapolating the results predicts a 0.3±0.3 mbarn and 11.5±1.1 mbarn thermal neutron (n,α) cross section for 147Sm and 149Sm, respectively. This measurement provides new information on (n,α) reaction cross sections. The method of measuring neutron induced charged particle emission cross sections presented here can be expanded to more isotopes of interest to reactor engineers or astrophysicists, as well as to (n,p) reactions.
Highly Conductive Aromatic Ionomers with Perfluorosulfonic Acid Side Chains for Elevated Temperature Fuel Cells

A versatile and facile synthetic approach to a new class of ionomers with rigid aromatic backbone and pendant perfluorinated sulfonic acid groups is described. Characterization of the prepared polymers has been carefully carried out by 1H and 19F NMR, elemental analysis, intrinsic viscosity, TGA and DSC. It is shown that the perfluorosulfonic acids greatly enhance the proton conductivity of ionomers under high temperature and low humidity conditions. The aromatic ionomers exhibit comparable proton conductivity to Nafion over a wide humidity range at elevated temperatures, while maintaining other outstanding properties of aromatic polymers, e.g. low gas permeability, excellent thermal and chemical stability and good mechanical properties. It is also demonstrated that the maximum power density and current density of the aromatic ionomers are 30% and 43% higher, respectively, than those of Nafion in initial fuel cell tests at 120 °C.
Spark plasma sintering: A high strain rate low temperature forming tool for ceramics

Abstract Spark plasma sintering (SPS) technique is being widely used to produce nanocrystalline materials by virtue of rapid sintering at relatively lower temperatures. In this investigation, fully dense Al 2 O 3 –ZrO 2 –MgAl 2 O 4 composite was superplastically formed into a complex shape using SPS equipment with a strain rate of approximately 10 −2 s −1 at temperatures as low as 1150 °C which is impossible to obtain by using conventional forming methods. Furthermore, a powder compact can be directly shaped into a complex shape, combining sintering and forming into one step. The product is fully dense and free of surface cracks. These results indicate that SPS can be a very competitive forming tool for ceramics as well other hard materials.
The Role of Social Comparison and Body Consciousness in Women’s Hostility Toward Women

Abstract When confronted with images of attractive women, women who are hostile toward women (HTW) may demonstrate negative upward comparison, i.e., feel bad about themselves, or they may discount other women’s attractiveness. We examined the relations between women’s HTW and negative upward comparison, discounting, and body consciousness. The effect on HTW of viewing images of women also was examined. HTW was higher among those first exposed to the images than among those in a control condition. In general, analyses of the two conditions separately indicated that HTW was associated with devaluing the attractiveness of attractive and average-looking images, but not with negative upward comparison. In contrast to the association between HTW and discounting, body shame was consistently related to negative upward comparison, as well as to HTW.
The interpersonal circle as a heuristic model for interpersonal research.

In this article, I review major advances in the development of the interpersonal circle and its measurement, as delineated by Timothy Leafy (1957) and his colleagues. In my early work (Lorr & McNair, 1963, 1965), an interpersonal Behavior Inventory consisting of manifest behavioral statements was constructed. The 14 categories were found to fit a circular order in several samples. Studies using LaForge and Suczek's (1955) Interpersonal Check List, and Wiggins's (1979) Interpersonal Adjective Scales further established the value of Leary's conceptions and extended them. Several major theorists, researchers, and clinicians including Benjamin, Carson, Horowitz, Kiesler, and Wiggins have been inspired by Leary and, in many cases, have extended his ideas in ways not originally envisioned. Recent research (e.g., Hofstee, de Raad, & Goldberg, 1992; Millon, 1987) demonstrated the pertinence of the interpersonal conception of personality to the 5-factor model and personality disorders.
T-type calcium channels regulate cortical plasticity in-vivo NR-D-08-7049

T-type voltage-dependent calcium channels may play an important role in synaptic plasticity, but lack of specific antagonists has hampered investigation into this possible function. We investigated the role of the T-type channel in a canonical model of in-vivo cortical plasticity triggered by monocular deprivation. We identified a compound (TTA-I1) with subnanomolar potency in standard voltage clamp assays and high selectivity for the T-type channel. When infused intracortically, TTA-I1 reduced cortical plasticity triggered by monocular deprivation while preserving normal visual response properties. These results show that the T-type calcium channel plays a central role in cortical plasticity.
Delayed pneumothorax after stab wound to thorax and upper abdomen: Truth or myth?

Abstract Background Stab wounds to the thorax and upper abdomen have the potential to cause pneumothorax (PTX). When a CXR (CXR) obtained during initial resuscitation is negative, a second CXR (CXR-2) is commonly performed with the goal of identifying delayed PTX. Objectives To assess the diagnostic yield of the CXR-2 in identifying delayed PTX. Methods Prospective observational study of patients (age ≥13 years) with stab wounds to the thorax (chest/back) and upper abdomen with suspected PTX, in a level 1 trauma centre. Patients were included if they had a negative initial CXR followed by a repeat CXR 3–6 h after the initial one. Exclusion criteria: patients who died, were transferred out of the ED, or received chest tubes before the second CXR. The outcome of interest was delayed PTX. All CXR were read by an attending radiologist. To test the inter-observer agreement, another blinded radiologist reviewed 20% of CXR. Continuous data is presented as mean ± standard deviation and categorical data as percentages with 95% confidence interval (CI). Kappa statistics were used to measure the inter-observer agreement between radiologists. Results Between January 2003 and December 2006 a total of 185 patients qualified for the enrollment (mean age: 28 ± 10 years, age range: 13–65, 94% male). Only 2 patients (1.1%, 95% CI, 0.4– 4.1%) had PTX on the CXR-2. Both patients received chest tubes. The inter-observer agreement for radiology reports was high (kappa: 0.79). Conclusion Occurrence of delayed PTX in patients with stab wounds to the thorax and upper abdomen and negative triage CXR is rare.