cssi/SciSciGPT-SciSciNet huggingface dataset:
Effects of Psychosocial Support on Patients with Metastatic Breast Cancer

This article reviews evidence that psychosocial support may influence the progression of cancer, as indicated by differences in length of survival. Psychotherapeutic methods that have proved to be effective involve direct confrontation of fears; expression of affect, including aegative feelings; provision of social support; and training in self-hypnosis for analgesia. Possible mechanisms for this psychosocial effect on progression of disease include changes in diet and exercise, better use and provision of health care, and positive effects on the sensitivity of the endocrine and immune systems to stress. The author reviews the limitations of these theories and offers suggestions for future research.
Initialization-Free Monocular Visual-Inertial State Estimation with Application to Autonomous MAVs

The quest to build smaller, more agile micro aerial vehicles has led the research community to address cameras and Inertial Measurement Units (IMUs) as the primary sensors for state estimation and autonomy. In this paper we present a monocular visual-inertial system (VINS) for an autonomous quadrotor which relies only on an inexpensive off-the-shelf camera and IMU, and describe a robust state estimator which allows the robot to execute trajectories at 2 m/s with roll and pitch angles of 20 degrees, with accelerations over 4 m/\(\text {s}^2\). The main innovations in the paper are an approach to estimate the vehicle motion without initialization and a method to determine scale and metric state information without encountering any degeneracy in real time.
Cement and Clay Grouting of Foundations: Pressure Grouting with Packers

The work of the Committee on Grouting of the Soil Mechanics and Foundations Division is divided among four task committees, concerned with (1) bituminous, (2) chemical, (3) cement and (4) clay grou...
Reduction in hepatic lipid and plasma estradiol in estrogenized chicks injected with ascorbic acid.

AbstractInjecting White Leghorn chicks every other day with 20 mg ascorbic acid significantly reduced the increase in liver weight and lipids caused by feeding a diet with 0.1% dienestrol diacetate. In chicks fed two different basal diets containing 0.1% dienestrol diacetate, injecting chicks every other day with 20 mg α-tocopherol did not significantly reduce liver weight or lipids while the ascorbic acid injections did. Injecting meat-type chicks implanted with estradiol with 10 mg ascorbic acid daily significantly reduced liver weight, liver lipids, and plasma estradiol, but injecting with 8 mg α-tocopherol daily had no significant effect.
Closure for Improved Reduced-order Models using High Performance Computing

Reduced-order models are often developed for complex flows for practical applications. POD-based reduced-order models have been successfully used to model two-dimensional flows. However, these models have limitations when employed in off-design parametric space. For complex flows, there is also a need to model higher POD modes which are not included in the Galerkin expansion and are required to close the system for energy dissipation. In this study, we attempt to develop a reduced-order model for a threedimensional flow past a cylinder at Re=1,000. We use high performance computing to capture 3-D structures on a fine grid and multiple processors to record 4000 snapshots. Standard POD models fails to predict the three-dimensional flows. We suggest a closure term in the reduced-order model to model the truncated modes. We present numerical results of the improved reduced-order model and predict correct dynamics of the threedimensional flow qualitatively and in statistical sense.
Particle-phonon interactions in 248 Cf and 249 Cf

The extent of particle-photon mixing in $^{248}\mathrm{Cf}$ and $^{249}\mathrm{Cf}$ has been determined using the $^{249}\mathrm{Cf}(d, t)$ and $^{249}\mathrm{Cf}(d, {d}^{\ensuremath{'}})$ reactions. ${K}^{\ensuremath{\pi}}={2}^{\ensuremath{-}}$ bands were identified at 593 and 1477 keV in $^{248}\mathrm{Cf}$. Since the only ${K}^{\ensuremath{\pi}}={2}^{\ensuremath{-}}$ neutron two quasiparticle configuration expected below 2 MeV in $^{248}\mathrm{Cf}$ is ${{{\frac{9}{2}}^{\ensuremath{-}}[734];{\frac{5}{2}}^{+}[622]}}_{2\ensuremath{-}}$, the second ${K}^{\ensuremath{\pi}}={2}^{\ensuremath{-}}$ band is considered to be predominantly of phonon character. In $^{249}\mathrm{Cf}$ a ${K}^{\ensuremath{\pi}}={\frac{5}{2}}^{+}$ band at 145 keV, known from decay scheme studies, receives a measurable population in the ($d, {d}^{\ensuremath{'}}$) reaction. The phonon admixture in the ${\frac{5}{2}}^{+}$ state which results from the ${{\frac{9}{2}}^{\ensuremath{-}}[734]\ensuremath{\bigotimes} {2}^{\ensuremath{-}} \mathrm{phonon}}$ configuration was determined to be (29\ifmmode\pm\else\textpm\fi{}5)%. The collective admixture in the ${\frac{5}{2}}^{+}$ state was also calculated from an octupole particle-hole interaction and was found to be 35%, in good agreement with the experimental value. The anomalously low energy of the ${\frac{5}{2}}^{+}$ state could not be entirely reproduced by this calculation.
Strained cycloalkynes as new protein sulfenic acid traps.

Protein sulfenic acids are formed by the reaction of biologically relevant reactive oxygen species with protein thiols. Sulfenic acid formation modulates the function of enzymes and transcription factors either directly or through the subsequent formation of protein disulfide bonds. Identifying the site, timing, and conditions of protein sulfenic acid formation remains crucial to understanding cellular redox regulation. Current methods for trapping and analyzing sulfenic acids involve the use of dimedone and other nucleophilic 1,3-dicarbonyl probes that form covalent adducts with cysteine-derived protein sulfenic acids. As a mechanistic alternative, the present study describes highly strained bicyclo[6.1.0]nonyne (BCN) derivatives as concerted traps of sulfenic acids. These strained cycloalkynes react efficiently with sulfenic acids in proteins and small molecules yielding stable alkenyl sulfoxide products at rates more than 100× greater than 1,3-dicarbonyl reagents enabling kinetic competition with physi...
α1-Adrenoceptor subtypes in rat renal resistance vessels : In vivo and in vitro studies

This study provides new information about the relative importance of different α1-adrenoceptors during norepinephrine (NE) activation in rat renal resistance vessels. In Sprague-Dawley rats, we mea...
Key technologies of automatic power flow chart generation based on CIM / G and its application

Key technologies of automatic power flow chart generation are introduced based on CIM / G:the automatic graph generation technology is applied to automatically allocate all power stations and lines of power network and generate the power flow chart;the increment synchronization technology is applied to automatically update the power flow chart according to the change of power stations and lines;the manual memory adjustment technology is applied to adjust the iconic coordinates on the power flow chart according to the stored coordinates after the locations of power stations and lines are manually changed;and the automatic 2D-3D graph transformation technology is applied to automatically,without manual modeling,generate the 3D GIS(Geographic Information System) power flow diagram according to the 2D grid power flow chart.
Design of a modulus based Round Robin scheduling algorithm

CPU performance critically depends upon efficiency of the scheduling algorithm. Algorithms like Round Robin (RR) and Shortest Job First (SJF) have shortcomings in some circumstances and are dedicated to a particular scheduling scenario like Round Robin compromises on the reduction of waiting time and SJF compromises on the reduction of response time. This article proposes a new modulus based Round Robin scheduling algorithm that simultaneously offers the least compromise on the reduction of waiting time, number of context switches and response time and discusses it in detail. This article also verifies the results through numerous numerical examples. This article also provides a comparison between the proposed algorithm and the median based and average based scheduling algorithms by discussing the effect of each algorithm over the trend of waiting time, response time and number of context switches numerically and empirically.
The syncytial knot: A sign of active syncytial proliferation

A study of human placenta from normal and abnormal pregnancies was undertaken to examine the phenomenon known as “syncytial knotting.” Specimens from 65 abnormal pregnancies and 20 normal pregnancies from 8 to 43 weeks’ gestation were studied by phase contrast and light microscopy. Histologic evidence showed: (1) that these knots are proliferative areas of trophoblast better described as syncytial sprouts; (2) that there is a great morphologic similarity between the syncytial sprout as seen by phase contrast microscopy and the proliferative syncytium at the tip of a placental villus called ”bud” and the clumping of syncytial nuclei described as “syncytial knots” and the migrating trophoblast found in the maternal and/or fetal circulation ; (3) that there is no evidence of histologic degeneration in these sprouts; (4) that degeneration of the syncytium with nuclear degeneration and thinning, rupture, or complete disappearance of syncytial layer is a different process from syncytial sprouting.
“Good” Grief: Subversion, Praxis, and the Unmasked Ethics of Griefing Guides

ABSTRACTThis article uses genre-field analysis (GFA) to examine Minecraft griefing guides: user-generated documentation that operationalizes destructive approaches to gameplay. Griefing guides promote subversive praxis while forwarding a utilitarian ethical system that alues hedonistic schadenfreude, running counter to morals of cooperation championed by most Minecraft players. Published in online forums where debates over conflicting praxis continue, these guides explicitly address, rather than mask, the negotiation of ideological values and ethical systems within a community.
Teaching Notes: A Teaching Case on Financial Mediation for the Forensic Accountant

The Professor (Instructor) serves as the mediator. A representative from the group representing the plaintiff and a representative for the defendant appears before the mediator with the group prepared lifestyle analysis. The mediator begins the session in any order preferred.
The peculiarity of money

One of the basic assumptions of Post Keynesian monetary theory is that we live in a world of uncertainty. A second assumption, implied by the first, is that all events take place in historical time. Historical time, furthermore, is seen as being irreversible. We do not have the luxury of doing something and, not liking the way it turns out, ask that we be allowed to start all over again, wiping out all the vestiges and consequences of our first try. Decisions to act, once implemented, tend to unfold along lines we do not expect. Commitments, in other words, are not easily undone and they are invariably undertaken in a penumbra of indeterminateness. They have a way of starting a chain of events that have an element of surprise in them. We are, consequently, forever trapped in the present, in a historically contingent world in which the future is largely unknown and unforeseeable. The only thing we can say with any assurance is that the future unfolding of events cannot be predicted, that what we expect to happen will most likely not happen. Being so, we must always be in the process of adapting our strategies to changing circumstances, again without any guarantee that our new-laid plans will work out any better than before; and so on ad infinitum as a new train of events unfolds conditioned by our newly developed responses to the unpredictable events occurring in an ever-shifting present.
US-Guided, Direct Puncture Retrograde Thoracic Duct Access, Lymphangiography, and Embolization: Feasibility and Efficacy.

Abstract Purpose To describe technical details, success rate, and advantages of direct puncture of the thoracic duct (TD) under direct ultrasound (US) guidance at venous insertion in the left neck. Materials and Methods All patients who underwent attempted thoracic duct embolization (TDE) via US-guided retrograde TD access in the left neck were retrospectively reviewed. Indications for lymphangiography were iatrogenic chyle leak, pulmonary lymphangiectasia, and plastic bronchitis. Ten patients with mean age 41.4 years (range, 21 d to 72 y) underwent US–guided TD access via the left neck. Technical details, procedural times, and clinical outcomes were evaluated. TD access time was defined as time from start of procedure to successful access of TD, and total procedural time was defined from start of procedure until TDE. Results All attempts at TD access via the neck were successful. Technical and clinical success of TDE was 60%. There were no complications. Mean TD access time was 17 minutes (range, 2–47 min), and mean total procedure time was 49 minutes (range, 25-69 min). Mean follow-up time was 5.4 months (range, 3–10 months). Conclusions TDE via US–guided access in the left neck is technically feasible and safe with a potential decrease in procedure time and elimination of oil-based contrast material.
University of Pittsburgh Cancer Institute - Hematopoietic Stem Cell Laboratory (HSC Lab)/Immunological Monitoring and Cellular Products Laboratory (IMCPL)

The Cancer Institute (UPCI) at the University of Pittsburgh Medical Center (UPMC) contains two cellular therapy laboratories: the Hematopoietic Stem Cell Laboratory (HSC Lab) and Cellular Products Laboratory/Gene Therapy Laboratory (CPL/GTL). These facilities are responsible for the final development and manufacturing of biological products required for University investigator-initiated research protocols, external partnerships, and contracts for cellular product manufacturing. This chapter describes the design features of these two laboratories.
Hippocampal-sparing and target volume coverage in treating 3 to 10 brain metastases: A comparison of Gamma Knife, single-isocenter VMAT, CyberKnife, and TomoTherapy stereotactic radiosurgery

Abstract Purpose Our purpose was to evaluate hippocampal doses and target volume coverage with and without hippocampal sparing when treating multiple brain metastases using various stereotactic radiosurgery (SRS) platforms. Methods and materials We selected 10 consecutive patients with 14 separate treatments who had been treated in our department for 3 to 10 brain metastases and added hippocampal avoidance contours. All 14 treatments were planned with GammaPlan for Gamma Knife, Eclipse for single isocenter volumetric modulated arc therapy (VMAT), TomoTherapy Treatment Planning System (TPS) for TomoTherapy, and MultiPlan for CyberKnife. Initial planning was performed with the goal of planning target volume coverage of V100 ≥95% without hippocampal avoidance. If the maximum hippocampal point dose (Dmax) was Results There was a median of 6 metastases per plan, with an average total tumor volume of 7.32 mL per plan. The median hippocampal Dmax (in Gy) without sparing averaged 1.65, 9.81, 4.38, and 5.46, respectively ( P P = .01). The overall average conformity indices for all plans ranged from 0.36 to 0.52. Conclusions Even with SRS, the hippocampi can receive a considerable dose; however, if the hippocampi are outlined as organs of risk, sparing these structures is feasible in nearly all situations with all 4 platforms, without detriment to target coverage, and should be considered in all patients undergoing SRS for multiple brain metastases. Summary Hippocampi play an important role in memory, and sparing of these structures in whole brain radiation can improve neurocognitive outcomes. The hippocampi are not routinely spared when using stereotactic radiosurgery. We evaluated the incidental dose to the hippocampi when treating multiple brain metastases and sought to examine if hippocampal sparing is feasible without detriment to target coverage. We found that hippocampal sparing is possible without affecting coverage or conformality in most cases across treatment platforms.
Methyl 5-methyl­pyrazine-2-carboxyl­ate

In the structure of methyl 5-methyl-2-pyrazine­carboxyl­ate, C7H8N2O2, the non-H atoms of the mol­ecule are nearly planar, with a dihedral angle of 5.4 (1)° between the plane of the pyrazine ring and the plane defined by C—C(O)—O. In the crystal, molecules are linked via C—H⋯N and C—H⋯O hydrogen bonds, forming layers parallel to (100).
Policy-based instructional reform in early education: how US Head Start teachers perceive instructional mandates

The goal of this study was to investigate how early childhood teachers reported responding to the instructional mandates they received. To answer our research questions, we completed semi-structured interviews with 20 early childhood teachers and coded their responses. The participating teachers were recruited from a large Head Start agency in the United States. We found that Head Start teachers reported feeling caught between two competing priorities: the priority the program placed on compliance with instructional routines and the priority the teachers placed on addressing children’s social, emotional, and behavioral needs. Essentially, teachers perceived that they must demonstrate compliance to the program’s instructional mandates first and foremost. Furthermore, they perceived that the program’s instructional coaches were monitoring their compliance with the mandates. As a result of this workplace context, the Head Start teachers reported that they did not feel permitted to alter the program’s required instructional procedures. The implications for policy and research are discussed.
Metabolic effects of physiological levels of caffeine in myotubes.

Caffeine has been shown to stimulate multiple major regulators of cell energetics including AMP-activated protein kinase (AMPK) and Ca2+/calmodulin-dependent protein kinase II (CaMKII). Additionally, caffeine induces peroxisome proliferator-activated receptor gamma coactivator 1-alpha (PGC-1α) and mitochondrial biogenesis. While caffeine enhances oxidative metabolism, experimental concentrations often exceed physiologically attainable concentrations through diet. This work measured the effects of low-level caffeine on cellular metabolism and gene expression in myotubes, as well as the dependence of caffeine's effects on the nuclear receptor peroxisome proliferator-activated receptor beta/delta (PPARβ/δ). C2C12 myotubes were treated with various doses of caffeine for up to 24 h. Gene and protein expression were measured via qRT-PCR and Western blot, respectively. Cellular metabolism was determined via oxygen consumption and extracellular acidification rate. Caffeine significantly induced regulators of mitochondrial biogenesis and oxidative metabolism. Mitochondrial staining was suppressed in PPARβ/δ-inhibited cells which was rescued by concurrent caffeine treatment. Caffeine-treated cells also displayed elevated peak oxidative metabolism which was partially abolished following PPARβ/δ inhibition. Similar to past observations, glucose uptake and GLUT4 content were elevated in caffeine-treated cells, however, glycolytic metabolism was unaltered following caffeine treatment. Physiological levels of caffeine appear to enhance cell metabolism through mechanisms partially dependent on PPARβ/δ.
Argument from a Pragmatic Perspective

This essay applies the work of Nicholas Rescher to the issue of defining the role of argument in producing knowledge. The essay explicates Rescher's “methodological pragmatism,” shows how it offers...
Yu in the Xunzi: toward a precise understanding

ABSTRACTAn ongoing dialogue in Xunzi scholarship addresses the role of yu (欲), often rendered as ‘desire,’ in motivation, but little has been said about what yu actually is, or whether the translation of ‘desire’ accurately reflects Xunzi’s use of the term. Employing textual analysis alongside research in cognitive science, most notably work on the so-called ‘wanting-liking’ distinction, I work toward a more precise understanding of Xunzi’s notion of yu and its functions. I suggest that yu be construed as a kind of desire with an emphasis on ‘wanting’ that, while motivational, differs from broader, less precise notions of desire, and that this feature constitutes a distinctive aspect of Xunzi’s philosophy of psychology. In so doing, I propose a particular methodological approach for the interpretation of classical Chinese philosophy: when interpreting concepts that are subjects of empirical inquiry, empirical findings should lead us to favor some interpretations over others.
HCMV Assembly Is Totally Tubular

Microtubules are normally organized at centrosomes, but other sites can also serve as microtubule organizing centers (MTOCs). In this issue of Developmental Cell, Procter et al. (2018) show that the human cytomegalovirus virion assembly compartment acts as a dynamic Golgi-derived MTOC where EB3 nucleates microtubules and regulates infectious virion production.
The Small and Rural Academic Library: Leveraging Resources and Overcoming Limitations

With over twenty-six contributing librarians who work at small, rural academic institutions, The small and rural academic library: leveraging resources and overcoming limitations contains a wealth ...
Development: The Concept

The word “development” as a synonym for societal progress acquired a special meaning through its metaphoric association with the Darwinian theory of evolution. This concept of development began in the social science literature with economic growth theories of the 1930s and 1940s as refined in the 1950s. Societies, in this concept, regardless of their separate historic, geographic, and cultural contexts are expected to pass through a pre-ordained sequence of recognizable stages. This “stages” hypothesis, implicit in some of the earlier development literature, was made very explicit around 1971. The forced assumption is that all social systems of the LMICs must replicate the historical processes through which the industrialized societies have already passed. Starting in the 1960s and gathering momentum through the following decades, an important revision in the concept of development has come about at least among some concerned intellectuals. Its advocacy as unbridled economic growth through industrialization has been questioned. The need for environmental sustainability in any path to genuine societal progress has now come to be widely recognized. Furthermore, it is concluded here that development as a concept, based as it is on an ahistoric stance, particularly where it presupposes a progressive process through which all cultures must pass, is clearly unacceptable. There is thus no justification to substantiate a claim that such a concept of development as widely understood and promoted has any basis in science or relevance to the LMICs and to the context of special concern here, namely that of South Asia.
Risk of weight gain for specific antipsychotic drugs: a meta-analysis.

People with schizophrenia are at considerably higher risk of cardiometabolic morbidity than the general population. Second-generation antipsychotic drugs contribute to that risk partly through their weight gain effects, exacerbating an already high burden of disease. While standard ‘as-randomized’ analyses of clinical trials provide valuable information, they ignore adherence patterns across treatment arms, confounding estimates of realized treatment exposure on outcome. We assess the effect of specific second-generation antipsychotics on weight gain, defined as at least a 7% increase in weight from randomization, using a Bayesian hierarchical model network meta-analysis with individual patient level data. Our data consisted of 14 randomized clinical trials contributing 5923 subjects (mean age = 39 [SD = 12]) assessing various combinations of olanzapine (n = 533), paliperidone (n = 3482), risperidone (n = 540), and placebo (n = 1368). The median time from randomization to dropout or trial completion was 6 weeks (range: 0–60 weeks). The unadjusted probability of weight gain in the placebo group was 4.8% across trials. For each 10 g chlorpromazine equivalent dose increase in olanzapine, the odds of weight gain increased by 5 (95% credible interval: 1.4, 5.3); the effect of risperidone (odds ratio = 1.6 [0.25, 9.1]) was estimated with considerable uncertainty but no different from paliperidone (odds ratio = 1.3 [1.2, 1.5]).
Reduced chemical model for low and high-temperature oxidation of fuel blends relevant to internal combustion engines

Abstract A hybrid approach is proposed to develop reduced kinetic models for complex engine-relevant fuels. The reduced mechanism is composed of a core submechanism including C0–C4 chemistry, ethanol chemistry, and NOx chemistry and a fuel-dependent submechanism. The fuel-dependent submechanism consists of three species and ten reactions describing both the low and high-temperature fuel decomposition pathways. Calibrations for these reactions can be made for single component and multicomponent mixtures using experimental targets or results from detailed kinetic mechanisms. In the present study, the methodology is applied to the combustion of gasoline surrogates. Reduced mechanisms are calibrated for primary reference fuels and multicomponent mixtures at engine-relevant pressures. The reduced mechanisms capture the low-temperature heat release and negative temperature coefficient (NTC) behavior, which are important to simulations of internal combustion engine performance. The mechanisms are very compact in size and can be easily calibrated for multicomponent mixtures without any detailed knowledge of the chemistry of the fuel components, making them well suited for CFD simulations of new fuel blends.
Complex Maze Learning in Rodents

An extensive body of research findings supports the view that normal aging in humans is associated with a defined dysfunction in memory processing. When sensorimotor performance requirements of tasks can be equated across age groups, the most salient age-related change appears in the ability to use secondary memory systems which represent the unlimited permanent store of newly acquired information (Poon, 1985). Age differences in sensory memory, which refers to the brief storage of sensory information; in primary memory, which refers to the temporary, limited capacity repository available for immediate recall; and in tertiary memory, which refers to memory for remote events, appear less robust (Poon, 1985). Much of the age-related impairment in retrieval of information from secondary memory can be attributed to deficient encoding processes, including organizational skills, visual imagination, depth of processing, and attention, as well as problems of equating motivational factors (Kausler, 1982; Poon, 1985). In terms of a storage-deficit hypothesis of age-related memory dysfunction, reviews of the literature have indicated that age differences in forgetting rates are minimal or nonexistent when effort is made to equate the original level of learning (Poon, 1985).
The Unusualness of Capital Punishment

From the short view, this is not a joyous period for opponents of the death penalty. From the long view, however, there is a chance that this new chapter could prove brighter for the abolitionist cause. There are reasons to think so, and this paper explores them. There is a tremendous amount of public criticism of capital punishment these days — some would say an unprecedented amount. Calling attention to the fallibility of the system is the opening wedge of the critique, but its deepest and broadest cuts strike at a different point: the extraordinary unusualness of the death penalty as practiced in America.
A New Philosophy on Preservation of Survey Evidence

Land surveyors are obligated to the public to advise some means to preserve and perpetuate land survey evidence. Many surveyors consider the placing of durable monuments as the only method available to preserve evidence. Besides monuments, other important methods can be used, such as astronomic directions, State Plane Coordinates, better understanding of measurements and accuracy, more complete notes on plats, better descriptions, maintenance of survey records, photogrammetry, and better education and registration procedures. Many practices toward preserving evidence are based on traditional habits rather than ideas which may be more rational. This is a symptom of a possible Generation gap in land surveying. If land surveying is to keep up with the times, the approaches to preservation of survey evidence must be rational and relevant. Suggestions to update the procedures are outlined herein.
SYNTHESIS OF FAST REACTOR NEUTRON ENERGY SPECTRA.

(1971). Synthesis of Fast Reactor Neutron Energy Spectra. Nuclear Science and Engineering: Vol. 46, No. 1, pp. 150-159.
Low Complexity Random Access Detection for 5G Millimeter Wave Communications

The millimeter wave (mmWave) communications have shown huge potential in 5G cellular networks for its feasibility to offer large bandwidth to effectively increase the system capacity. The beamforming technology can efficiently lessen the severe path loss in the mmWave band via antennas arrays. However, in random access (RA) process, the base station cannot fully benefit from beamforming due to the lack of best beam pair of transmit-receive. Furthermore, increasing antenna dimensions bring great challenge in RA receiver design to satisfy the short latency requirement of 5G. In this work, a low complexity RA receiver based on two-stage filter is proposed to adapt the latest development of standards and to alleviate the severe fading in mmWave systems. Through simulations and comparisons, we demonstrate that the proposed design shortens processing delay and the receiver provides the same missed detection probability with the conventional approach.
Regeneration of neurotransmission transcriptome in a model of epileptic encephalopathy after antiinflammatory treatment

Inflammation is an established etiopathogenesis factor of infantile spasms (IS), a therapy-resistant epileptic syndrome of infancy. We investigated the IS-associated transcriptomic alterations of neurotransmission in rat hypothalamic arcuate nucleus, how they are corrected by antiinflamatory treatments and whether there are sex differences. IS was triggered by repeated intraperitoneal administration of N-methyl-D-aspartic acid following anti-inflammatory treatment (adreno-cortico-tropic-hormone (ACTH) or PMX53) or normal saline vehicle to prenatally exposed to betamethasone young rats. We found that treatments with both ACTH and PMX53 resulted in substantial recovery of the genomic fabrics of all types of synaptic transmission altered by IS. While ACTH represents the first line of treatment for IS, the even higher efficiency of PMX53 (an antagonist of the complement C5a receptor) in restoring the normal transcriptome was not expected. In addition to the childhood epilepsy, the recovery of the neurotransmission genomic fabrics by PMX53 also gives hope for the autism spectrum disorders that share a high comorbidity with IS. Our results revealed significant sex dichotomy in both IS-associated transcriptomic alterations (males more affected) and in the efficiency of PMX53 anti-inflammatory treatment (better for males). Our data further suggest that anti-inflammatory treatments correcting alterations in the inflammatory transcriptome may become successful therapies for refractory epilepsies.
Nonmetabolic functions of metabolic enzymes in cancer development

Metabolism is a fundamental biological process composed of a series of reactions catalyzed by metabolic enzymes. Emerging evidence demonstrates that the aberrant signaling in cancer cells induces nonmetabolic functions of metabolic enzymes in many instrumental cellular activities, which involve metabolic enzyme-mediated protein post-translational modifications, such as phosphorylation, acetylation, and succinylation. In the most well-researched literatures, metabolic enzymes phosphorylate proteins rather than their metabolites as substrates. Some metabolic enzymes have altered subcellular localization, which allows their metabolic products to directly participate in nonmetabolic activities. This review discusses how these findings have deepened our understanding on enzymes originally classified as metabolic enzymes, by highlighting the nonmetabolic functions of several metabolic enzymes responsible for the development of cancer, and evaluates the potential for targeting these functions in cancer treatment.
Long Horizon Repeated Games: How Does Ending Rule Affect Decisions in High Δ Games

This paper looks to see if subjects approach long, indefinitely repeated Prisoner's Dilemma games featuring discounted payoffs with an option to opt out differently from how they approach long, indefinitely repeated Prisoner's Dilemma games that are randomly terminated. I show under relatively general assumptions that the critical δ ∗ -value, above which cooperation can be supported as a Subgame Perfect Equilibrium, differs between the two environments. A between-subject design with δ = 0.98 was used to determine if subject behavior did vary by treatment. First period and all period cooperation rates were found to be higher in the random termination treatment compared to the discounted treatment. The evolution of cooperation across supergames also differed between the two treatments. Behavior in the discounted treatment did not follow the patterns typically observed in the literature. Lastly, the Strategy Frequency Estimation Method (SFEM) was used to determine whether or not subjects in different treatments used different repeated game strategies. I find that subjects in the discounted treatment were more likely to play strategies that defect initially (All D, STFT), but cooperative subjects tended to play more forgiving strategies (TFT, STFT). Conversely, subjects in the randomly terminated treatment tended to play more initially cooperative, yet less forgiving strategies (Grim, Grim2).
Facial Affect and Interpersonal Affiliation: Displays of Emotion During Relationship Formation in Social Anxiety Disorder.

Social anxiety disorder (SAD) often involves difficulty developing relationships. Facial expressions are important in relationship formation, but data are limited regarding facial display productio...
Borders within Borders: The Impact of Occupational Licensing on Immigrant Incorporation:

Over the past four decades, occupational regulation, particularly licensing, which creates a legal right to practice, has engulfed the American occupational structure. Occupational licensure resear...
Alphabet Letter Recognition And Emergent Literacy Abilities Of Rising Kindergarten Children Living In Low-Income Families

Alphabet letter recognition item responses from 1,299 rising kindergarten children from low-income families were used to determine the dimensionality of letter recognition ability. The rising kindergarteners were enrolled in preschool classrooms implementing a research-based early literary curriculum. Item responses from the TERA-3 subtests were also analyzed. Results indicated alphabet letter recognition was unitary. The ability of boys and younger children was less than girls and older children. Child-level letter recognition was highly associated with TERA-3 measures of letter knowledge and conventions of print. Classroom-level mean letter recognition ability accounted for most of variance in classroom mean TERA-3 scores.
Resounding in the Human Body as the ‘True Sanskrit’ of Nature: Reading Sound Figures in Novalis’ The Novices of Sais

The early German Romantics Novalis and Johann Wilhelm Ritter interpret Klangfiguren (“sound figures,” known most commonly as “Chladni Figures”) as representing the universal language of nature, with sound containing its own writing—sound that can be seen, and writing that can be heard—a language that is therefore revealed with the human body as its instrument. Their postulations serve as a useful model on how to consider music’s and more generally sound’s communication with the human body—focusing not on how it is processed through the ears, but rather by the body itself.
Beyond School Engagement: School Adaptation and Its Role in Bolstering Resilience Among Youth Who Have Been Involved with Child Welfare Services

School adaptation is a critical risk or resilience factor for at-risk youth. The overall aim was to improve our conceptualization of school adaptation as a risk or resilience factor for youth in contact with the child welfare system. We hypothesized that school adaptation includes a range of indicators that would distinguish youth into meaningful groups, that group membership is related to known risk factors, and that school adaptation groups predicts mental health functioning. Participants included 2668 youth in contact with the child welfare system following an investigation for alleged maltreatment. Youth, teachers, caregivers, and caseworkers provided relevant information. Patterns among school adaptation indicators were determined via latent profile analysis, relationships between latent profiles and child welfare risk factors were determined using multinomial logistic regression, and relationships between profiles and later mental health were explored using hierarchal linear regression. Latent profile analysis supported the interpretation of four profiles of school adaptation, including a high overall adaptation group, a moderate overall adaptation with somewhat poor behavior group, a low overall adaptation with poor behavior group, and a low overall adaptation with good behavior and low emotional/cognitive engagement group. School adaptation profiles were related to some demographic variables but were largely independent of child welfare indicators. Maltreatment severity predicted profile membership overall, but differences between groups were not significant. Maltreatment severity and profile membership predicted youth mental health functioning 3 years later. For youth involved with child welfare services, profiles of school adaptation appear to be better predictors of mental health outcomes than type, substantiation, or severity of maltreatment, demonstrating the important protective role of school in the lives of at-risk youth.
Decubitus CT Myelography for CSF-Venous Fistulas: A Procedural Approach

Decubitus CT myelography is a reported method to identify CSF-venous fistulas in patients with spontaneous intracranial hypotension. One of the main advantages of decubitus CT myelography in detecting CSF-venous fistulas is using gravity to dependently opacify the CSF-venous fistula, which can be missed on traditional myelographic techniques. Most of the CSF-venous fistulas in the literature have been identified in patients receiving general anesthesia and digital subtraction myelography, a technique that is not performed at all institutions. In this article, we discuss the decubitus CT myelography technique and how to implement it in daily practice.
Chat in the Hat: A Portable Interpreter for Sign Language Users

Many Deaf and Hard-of-Hearing (DHH) individuals rely on sign language interpreting to communicate with hearing peers. If on-site interpreting is not available, DHH individuals may use remote interpreting over a smartphone video-call. However, this solution requires the DHH individual to give up either 1) the use of one signing hand by holding the smartphone or 2) their ability to multitask and move around by propping the smartphone up in a fixed location. We explore this problem within the context of the workplace, and present a prototype hands-free device using augmented reality glasses with a hat-mounted fisheye camera and mic/speaker. To explore the validity of our design, we conducted 1) a video interpretability experiment, and 2) a user study with 18 participants (9 DHH, 9 hearing) in a workplace environment. Our results suggest that a hands-free device can support accurate interpretation while enhancing personal interactions.
Ancient grains as novel dietary carbohydrate sources in canine diets

Ancient grains are becoming an increasingly abundant carbohydrate source in the pet food market as a result of their popularity and novelty in the human market. Thus, it is imperative to evaluate the characteristics of these ingredients in vivo. Ten adult intact female beagles were used in a replicated 5 × 5 Latin square design. Five dietary treatments were evaluated containing either: rice (CON), amaranth (AM), white proso millet (WPM), quinoa (QU), or oat groats (OG). All diets were formulated to include 40% of the test grain and to be isonitrogenous, isocaloric, and nutritionally complete and balanced for adult dogs at maintenance. The objectives were 1) to evaluate the effects of the novel carbohydrate sources on total apparent total tract digestibility (ATTD), fecal microbiota, and fermentative end-product concentrations and 2) to evaluate the effects of novel carbohydrate sources on the postprandial glycemic and insulinemic responses in healthy adult dogs. All diets were well accepted by the dogs and fecal scores remained within the ideal range for all treatments. In terms of ATTD, all diets were well digested by the dogs; WPM had the highest digestibility of dry and organic matter in contrast with dogs fed the other treatments (P < 0.05). Additionally, ATTD of total dietary fiber was highest for WPM (72.6%) in contrast with QU (63.5%) and CON (50.8%) but did not differ from AM (65.7%) and OG (66.6%). Dogs fed AM or OG had greater (P < 0.05) fecal concentrations of total short-chain fatty acids, as well as propionate and butyrate concentrations, than CON. Ancient grain inclusion appears to beneficially shift fecal microbial populations, with increases in relative abundances of butyrogenic bacteria (i.e., members of the Lachnospiraceae family) observed for OG and reductions in Fusobacteriaceae for both AM and OG when compared with CON. Postprandial glycemic and insulinemic responses did not differ among treatments. Together, these data suggest that ancient grains can be included up to 40% of the diet while eliciting beneficial effects on the overall host health without detrimentally affecting nutrient digestibility.
Does Playing a Video Game Really Result in Improvements in Psychological Well-Being in the Era of COVID-19?

Abstract This study examines the structural relationships between the perceived value dimensions of quality, emotional, price, and social, positive and negative emotions, psychological well-being, and loyalty in the video game context along with the moderating role of the perceived severity of COVID-19. This study collected data from 258 video game consumers in the United States via three waves of surveys. The findings of structural equation modeling revealed significant associations among the perceived value dimensions, emotions, psychological well-being, and loyalty. In addition, the moderating role of the perceived severity of COVID-19 showed that the impact of video game consumers' positive emotions on psychological well-being would be weaker with a high level of perception of the severity of COVID-19. Based on the empirical results, this research proposes theoretical (i.e., extension of the cognitive appraisal theory in a digital environment, and integration of the cognitive appraisal theory with the two-factor theory of motivation) and practical implications (i.e., how to increase levels of users’ psychological well-being and loyalty via video games) for the video game industry during and after the era of COVID-19.
Management Considerations for Lipid Disorders During Pregnancy

Dyslipidemias including familial hypercholesterolemia and elevated lipoprotein (a) are not uncommon in young women who may desire pregnancy. In all women, abnormal lipid metabolism has been linked to adverse outcomes during pregnancy, including hypertensive disease of pregnancy, gestational diabetes mellitus, and preterm birth. Optimal management of dyslipidemias in pregnant women remains undefined, as statins are contraindicated in this group. Recent literature questions this traditional avoidance of statins, however, as well as explores their potential benefit in pre-eclampsia specifically. In this review, the arsenal of nutrition, bile acid resins, omega-3 fatty acids, and low-density lipoprotein cholesterol apheresis is explored, as are newer therapies like mipomersen and proprotein convertase subtilisin/kexin type 9 inhibitors, for the management of dyslipidemias during pregnancy.
Developing user-centered collections at a research library: An Evidence-Based Acquisition (EBA) pilot in STEM

Abstract The increasing cost of science and engineering books in both print and electronic format continues to challenge academic libraries' ability to support teaching, learning and research. Libraries are under pressure to meet the growing need of electronic resources with a flat or shrinking budget. To seek a solution to this phenomenon, the Stony Brook University Libraries works with publishers to implement an Evidence-Based Acquisition (EBA) model in engineering and science. Using this EBA model, the Stony Brook University Libraries empowers users to participate in purchase decisions on ebooks at the end of the agreed period with the publisher. Before the final purchase of the science and engineering ebooks, users have full access to over 3000 ebooks in the collection. This study is to understand the use pattern of ebooks acquired through EBA model versus subscriptions by analyzing use reports, percent used, and use intensity. The use comparison of two acquisition models provides insights on the ebook collection strategy and EBA impact. The implementation process on the Alma/Primo VE platform is also shared.
Upcycling simulated food wastes into superactivated hydrochar for remarkable hydrogen storage

Abstract In an effort of developing hydrogen storage material, the goal of this study was to explore the potential of the abounding food waste biomass as a precursor for the development of porous carbon materials for remarkable hydrogen storage. Therefore, in this study, simulated food waste, a mixture of six commonly disposed food items (apple, bread, green bean, cabbage, cheese, and canned chicken), was hydrothermally carbonized at 220 °C followed by chemical activation at 800 °C using various activating agent (KOH) to food waste hydrochar ratio (i.e., 2:1, 3:1 and 4:1). The solid products, hereafter called superactivated hydrochars, were characterized by proximate and ultimate analyses as well as X-ray diffractometer (XRD) and through nitrogen adsorption isotherms at 77 K to analyze the changes in the material including its surface porosity parameters (surface area, pore volume, and pore size distribution) as the food waste underwent chemical and morphological modifications. The gravimetric (wt%) hydrogen storage capacity of the superactivated hydrochars were then conducted under 77 K and various pressure of 0–23 bar. Results showed that the surface area and total pore volume in the superactivated hydrochars were in the range of, as high as, 2070 to 2885 m2/g and 0.98 to 1.93 cm3/g, respectively. The remarkable hydrogen storage capacity was observed of as high as 6.15 wt% at 23 bar and 77 K for the superactivated hydrochar produced with a KOH to food waste hydrochar ratio of 4:1. This distinctly highlights the pertinent upcycling technique of food waste to be effective in developing efficient hydrogen storage material.
The homogeneous Hilbert problem: Practical application

The purpose of my talk is to make it a little easier to get started actually using the Hauser-Ernst formalism in order to generate solutions of the Einstein-Maxwell field equations without having to digest the whole series of papers which we have published in the Physical Review and the Journal of Mathematical Physics.1-5