cssi/SciSciGPT-SciSciNet huggingface dataset:
Sound Stories for General Music.

Language and music literacy share a similar process of understanding that progresses from sensory experience to symbolic representation. The author identifies Bruner’s modes of understanding as they relate to using narrative in the music classroom to enhance music reading at iconic and symbolic levels. Two sound stories are included for preschool-age children and for students in elementary grades.
A new approach for the numerical solution of diffusion equations with variable and degenerate mobility

Abstract We propose a novel approach for the numerical integration of diffusion-type equations with variable and degenerate mobility or diffusion coefficient. Our focus is the Cahn–Hilliard equation which plays a prominent role in phase field models of fluids and soft materials but the methodology has a more general applicability. The central idea is a split method with a linearly implicit component and an analytic step to integrate out the variable mobility. The proposed method is robust, free of high order stability constraints, and its cost is comparable to that of solving the linear Heat Equation with the backward Euler Method. Moreover, by design, the numerical solution is guaranteed to be strictly bounded by the stable, constant states.
1α, 25‐Dihydroxyvitamin D3 specific regulation of growth, morphology, and fibronectin in a human osteosarcoma cell line

The ability of the hormonally active vitamin D metabolite, 1 alpha, 25-dihydroxyvitamin D3, to affect cell growth, morphology and fibronectin production has been examined using the MG-63 human osteosarcoma cell line. Hormone treatment reduced cell growth rate, saturation density and [3H]thymidine incorporation. Inhibition was specific for 1 alpha, 25-dihydroxyvitamin D3 relative to other vitamin D metabolites (1 alpha, 25-dihydroxyvitamin D3 greater than 25-dihydroxyvitamin D3 greater than 24R,25-dihydroxyvitamin D3 greater than D3), antagonized by high concentrations of serum and readily reversed by removal of 1 alpha, 25-dihydroxyvitamin D3 from the culture medium. Hormone treatment also increased cell associated alkaline phosphatase activity up to twofold and altered morphology such that treated cells were more spread out on the culture dish and contained more cytoplasmic processes. Significantly, 1 alpha, 25-dihydroxyvitamin D3 increased cellular and medium concentrations of fibronectin, a glycoprotein known to be involved in cellular adhesiveness. MG-63 cells contain a specific 1 alpha, 25-dihydroxyvitamin D3 receptor which may mediate these responses.
Development of Oral Reading Fluency in Children With Speech or Language Impairments A Growth Curve Analysis

This longitudinal study used piece-wise growth curve analyses to examine growth patterns in oral reading fluency for 1,991 students with speech impairments (SI) or language impairments (LI) from first through third grade. The main finding of this study was that a diagnosis of SI or LI can have a detrimental and persistent effect on early reading skills. Results indicated differences between subgroups in growth trajectories that were evident in first grade. A large proportion of students with SI or LI did not meet grade-level reading fluency benchmarks. Overall students with SI showed better performance than students with LI. Reading fluency performance was negatively related to the persistence of the SI or LI; the lowest performing students were those originally identified with SI or LI whose diagnosis changed to a learning disability. The results underscore the need to identify, monitor, and address reading fluency difficulties early among students with SI or LI.
BASIC SENSIBLE QUALITIES AND THE STRUCTURE OF APPEARANCE

A sensible quality is a perceptible property, a property that physical objects (or events) perceptually appear to have. Thus smells, tastes, colors and shapes are sensible qualities. An egg, for example, may smell rotten, taste sour, and look cream and round.1,2 The sensible qualities are not a miscellanous jumble—they form complex structures. Crimson, magenta, and chartreuse are not merely three different shades of color: the first two are more similar than either is to the third. Familiar color spaces or color solids capture, to a greater or lesser extent, these relations between the colors. The same goes for sensible qualities perceived in other modalities: middle C, high C, and D are not merely three different notes, and the taste of lemons, oranges, and sugar cubes are not merely three different tastes. How can this structure of appearance be explained? One idea is that sensible qualities are of two sorts: basic and derived. The basic sensible qualities are the building blocks from which the derived sensible qualities can be
Prominin-1 Is a Novel Regulator of Autophagy in the Human Retinal Pigment Epithelium.

Purpose Prominin-1 (Prom1) is a transmembrane glycoprotein, which is expressed in stem cell lineages, and has recently been implicated in cancer stem cell survival. Mutations in the Prom1 gene have been shown to disrupt photoreceptor disk morphogenesis and cause an autosomal dominant form of Stargardt-like macular dystrophy (STGD4). Despite the apparent structural role of Prom1 in photoreceptors, its role in other cells of the retina is unknown. The purpose of this study is to investigate the role of Prom1 in the highly metabolically active cells of the retinal pigment epithelium (RPE). Methods Lentiviral siRNA and the genome editing CRISPR/Cas9 system were used to knockout Prom1 in primary RPE and ARPE-19 cells, respectively. Western blotting, confocal microscopy, and flow sight imaging cytometry assays were used to quantify autophagy flux. Immunoprecipitation was used to detect Prom1 interacting proteins. Results Our studies demonstrate that Prom1 is primarily a cytosolic protein in the RPE. Stress signals and physiological aging robustly increase autophagy with concomitant upregulation of Prom1 expression. Knockout of Prom1 increased mTORC1 and mTORC2 signaling, decreased autophagosome trafficking to the lysosome, increased p62 accumulation, and inhibited autophagic puncta induced by activators of autophagy. Conversely, ectopic overexpression of Prom1 inhibited mTORC1 and mTORC2 activities, and potentiated autophagy flux. Through interactions with p62 and HDAC6, Prom1 regulates autophagosome maturation and trafficking, suggesting a new cytoplasmic role of Prom1 in RPE function. Conclusions Our results demonstrate that Prom1 plays a key role in the regulation of autophagy via upstream suppression of mTOR signaling and also acting as a component of a macromolecular scaffold involving p62 and HDAC6.
A LIPOGENIC TOXIN RELEASED THROUGH THE INTERACTION OF A NEW CYTOPATHIC AGENT (LIPOVIRUS) AND CULTURED HUMAN CELLS

The release of a toxic product from cultured human cells infected by a new cytopathic agent (the lipovirus) was described. This toxin was dissociable from the infectious particles. It induced sudanophilia of human and mouse cells, an increase in the total fatty acid content, and a change in the major constituent fatty acids. Similar toxin was not demonstrated in cultures infected by the vaccinia herpes simplex, adeno 3, polyoma, polio 1 and 2, Coxsackie B1, parainfluenza A, and Rous sarcoma viruses. Preliminary characterization indicated that this toxin was resistant to tryptic digestion and could not be dialyzed or neutralized by human gamma globulin. It was inactivated at 58°C for 30 minutes, but stable at 37°, 4°, and –60°C. The significance of these findings is discussed.
Social caching and observational spatial memory in pinyon jays

In the wild, pinyon jays (Gymnorhinus cyanocephalus) live in large, integrated flocks and cache tens of thousands of seeds per year. This study explored social aspects of caching and recovering by pinyon jays. In Experiment 1, birds cached in a large experimental room under three conditions: alone, paired with a dominant, and paired with a subordinate. In all cases, birds recovered caches alone seven days later. Individuals ate more seeds before caching when alone than when paired and started caching sooner when subordinate than when dominant. Pinyon jays accurately returned to sites containing their own caches but not to sites containing caches made by partner birds. However, they went to areas containing partner caches sooner than would be expected, indicating memory for the general areas containing caches made by other pinyon jays. In Experiments 2 and 3 birds were placed closer to each other and allowed to recover one or two days after caching. In Experiment 2, both free-flying and caged observers found caches with accuracies above chance. Cachers made significantly fewer errors than observers. During Experiment 3, caged observers saw the cachers recover some seeds one day after they were cached. On the next day cachers and observers were separately allowed to visit all cache sites. Both cachers and observers performed accurately and did not differ in accuracy. Neither group discriminated between extant and depleted caches. Observational spatial memory in pinyon jays may allow economical cache robbery by wild pinyon jays under some circumstances, particularly shortly after caches are created.
The Economics of Child Custody

I develop a model of marriage in which spouses decide on investments in child quality during marriage, and on the allocation of child custody should they divorce. The custodial allocation determines the share of the marital surplus each spouse appropriates, which in turn influences spouses' investment incentives. The custodial allocation therefore has both distributional and efficiency consequences. I derive the equilibrium investments and optimal custodial allocation, and identify three channels through which making divorce easier affects child welfare: investments in child quality during marriage, the likelihood of divorce, and the allocation of custody if divorce occurs.
Modification of the Koyanagi technique for the single stage repair of proximal hypospadias.

Purpose: We describe a modification of the Koyanagi technique for hypospadias. Use of opposing parameatal-based skin flaps that extend distally to incorporate the inner layer of the prepuce was modified to preserve blood supply to the flaps in an attempt to reduce complications and improve results.Materials and Methods: During the last 7 years 20 boys underwent treatment of proximal hypospadias using the modified hypospadias repair.Results: Cosmetic and functional, long-term (mean 34 months) results were excellent. Complications consisted of 4 urethrocutaneous fistulas (20%). There were no instances of meatal stenosis, diverticulum or urethral stricture.Conclusions: The modified technique permits 1-stage repair of proximal hypospadias with a low complication rate.
A new family of capillary waves

A new family of finite-amplitude periodic progressive capillary waves is presented. They occur on the surface of a fluid of infinite depth in the absence of gravity. Each pair of adjacent waves touch at one point and enclose a bubble at pressure P. P depends upon the wave steepness s, which is the vertical distance from trough to crest divided by the wavelength. Previously Crapper found a family of waves without bubbles for 0 ≤ s ≤ s* = 0·730. Our solutions occur for all s > s** = 0·663, with the trough taken to be the bottom of the bubble. As s → ∞, the bubbles become long and narrow, while the top surface tends to a periodic array of semicircles in contact with one another. The solutions were obtained by formulating the problem as a nonlinear integral equation for the free surface. By introducing a mesh and difference method, we converted this equation into a finite set of nonlinear algebraic equations. These equations were solved by Newton's method. Graphs and tables of the results are included. These waves enlarge the class of phenomena which can occur in an ideal fluid, but they do not seem to have been observed. © 1980, Cambridge University Press. All rights reserved.
Online, asynchronous schema change in F1

We introduce a protocol for schema evolution in a globally distributed database management system with shared data, stateless servers, and no global membership. Our protocol is asynchronous--it allows different servers in the database system to transition to a new schema at different times--and online--all servers can access and update all data during a schema change. We provide a formal model for determining the correctness of schema changes under these conditions, and we demonstrate that many common schema changes can cause anomalies and database corruption. We avoid these problems by replacing corruption-causing schema changes with a sequence of schema changes that is guaranteed to avoid corrupting the database so long as all servers are no more than one schema version behind at any time. Finally, we discuss a practical implementation of our protocol in F1, the database management system that stores data for Google AdWords.
Negative regulation of gene expression by TGF-beta.

Stromelysin gene expression is transcriptionally activated by a number of growth factors (e.g., EGF and PDGF), tumor promoters (e.g., TPA), and oncogenes (e.g., ras, src) through an AP-1-dependent mechanism. TGF-β repression of stromelysin induction is mediated at the level of transcription by an element located at position −709 in the rat stromelysin promoter referred to as the TGF-β inhibitory element (TIE). A TIE-binding protein complex is induced by treatment of rat fibroblasts with TGF-β. This protein complex contains the protooncogene c-fos, and induction of c-fos by TGF-β is required for the repressive effects of TGF-β on stromelysin gene expression. Interestingly, c-fos induction is also required for stimulation of stromelysin expression by EGF in rat fibroblasts. Preliminary studies suggest that differential regulation of members of the jun family of early-response genes may explain this apparent paradox and determine whether stromelysin is induced or repressed by growth factors. TGF-β stimulation therefore initiates a cascade of events that results in a specific pattern of gene expression: the direct stimulation of early-response genes can lead to subsequent induction or repression of other genes. Growth factor regulation of matrix metalloproteinases appears to play a role in embryonic development in the morphogenesis of the murine lung. Treatment of embryonic lungs in organ culture with the growth factors EGF or TGF-β results in stimulation of growth and inhibition of branching morphogenesis. A similar inhibition of branching was observed when these lung rudiments were treated with the matrix metalloproteinase collagenase. Most interestingly, the effects of EGF and TGF-β can be completely reversed by the tissue inhibitor of metalloproteinases, TIMP. TGF-β has the opposite effect on growth of murine lung rudiments—growth is inhibited in a dose-dependent manner. This example illustrates a potential role for growth factor regulation of matrix-degrading metalloproteinases in complex developmental processes. © 1992 Wiley-Liss, Inc.
Richardson Number and Ocean Mixing: Towed Chain Observations

Abstract A 7.2-km tow in the upper seasonal thermocline of the Sargasso Sea with an 80-m aperture thermistor– conductivity chain and shipborne 150-kHz ADCP is examined to determine the relationship between patches of scalar activity and buoyancy frequency, vertical shear, and gradient Richardson number (Ri). The horizontal temperature gradient variance in the 0.5–3-m band normalized by the mean gradient squared is used as a measure of scalar activity. Two-dimensional images show qualitative coincidence between patches of activity and low Ri computed over 10-m vertical and 90-m horizontal scales. Hypothesis testing quantifies and supports these visual results. The null hypothesis, “scalar activity is independent of Ri number,” fails at the 90% confidence interval for 10-m Ri < 0.8 for a threshold representing ∼9% of the most active regions. The probability of scalar activity increases rapidly as the 10-m Ri approaches 0.25. The results are robust for vertical smoothing from 4 to 20 m, although the details ...
On measuring the quality of Wikipedia articles

This paper discusses an approach to modeling and measuring information quality of Wikipedia articles. The approach is based on the idea that the quality of Wikipedia articles with distinctly different profiles needs to be measured using different information quality models. We report on our initial study, which involved two categories of Wikipedia articles: "stabilized" (those, whose content has not undergone major changes for a significant period of time) and "controversial" (the articles, which have undergone vandalism, revert wars, or whose content is subject to internal discussions between Wikipedia editors). We present simple information quality models and compare their performance on a subset of Wikipedia articles with the information quality evaluations provided by human users. Our experiment shows, that using special-purpose models for information quality captures user sentiment about Wikipedia articles better than using a single model for both categories of articles.
Autoimmune-mediated glucose intolerance in a mouse model of systemic lupus erythematosus

Systemic lupus erythematosus (SLE) is an autoimmune disease characterized by the production of autoantibodies against self-antigens such as double-stranded DNA and phospholipids. Classical comorbidities of SLE include glomerulonephritis, infection, cardiovascular disease, arthritis, skin disorders, and neurological disease. In addition to these classical comorbidities, there is emerging evidence that SLE patients are at higher risk of developing insulin resistance and other components of the metabolic syndrome. Visceral adipose tissue inflammation is a central mediator of insulin resistance in the obese setting, but the mechanism behind the pathogenesis of metabolic disease in the SLE patient population is unclear. We hypothesize that lupus-associated changes in the adaptive immune system are associated with disruption in glucose homeostasis in the context of SLE. To test this hypothesis, we assessed the metabolic and immunological phenotype of SLE-prone B6.SLE mice. B6.SLE mice fed a low-fat diet had significantly worsened glucose tolerance, increased adipose tissue insulin resistance, increased β-cell insulin secretion, and increased adipocyte size compared with their respective B6 controls. Independently of diet, B cells isolated from the white adipose tissue of B6.SLE mice were skewed toward IgG production, and the level of IgG1 was elevated in the serum of SLE-prone mice. These data show that B6.SLE mice develop defects in glucose homeostasis even when fed a low-fat diet and suggest that B cells may play a role in this metabolic dysfunction.
Separation-Based Joint Decoding in Compressive Sensing

We introduce a joint decoding method for compressive sensing that can simultaneously exploit sparsity of individual components of a composite signal. Our method can significantly reduce the total number of variables decoded jointly by separating variables of large magnitudes in one domain and using only these variables to represent the domain. Furthermore, we enhance the separation accuracy by using joint decoding across multiple domains iteratively. This separation-based approach improves the decoding time and quality of the recovered signal. We demonstrate these benefits analytically and by presenting empirical results.
Optimization of Information-Processing Optical Systems by Transcorrelation-Function Maximization*

A method for optimizing optical systems which process information-carrying signals is presented. The method consists of deriving the transcorrelation function for a general optical system and then maximizing it with respect to the variable parameters of the system. The transcorrelation function is a space- and time-averaged statistic relating the desired object, or “signal” field, and the system output, or image field. The suggested procedure not only minimizes aberrations in the system itself, but also discriminates against noise in both the object and image regions. It can be shown that the maximization of the transcorrelation coefficient also maximizes the useful information content at the output relative to the desired input. For this reason, the criterion is particularly appropriate to optical systems which are used for transmitting and processing information.An example of the application of transcorrelation theory to lens design is carried out at the end of the paper. A meniscus lens is chosen for optimization, where the variable parameters are the radii of curvature of the lens surfaces, which are constrained to be circular in cross section. The transcorrelation function for this lens is determined, and the optimum radii are found by maximizing this function.
Saccharomyces cerevisiae G1 Cyclins Are Differentially Involved in Invasive and Pseudohyphal Growth Independent of the Filamentation Mitogen-Activated Protein Kinase Pathway

Several lines of evidence suggest that the morphogenetic transition from the yeast form to pseudohyphae in Saccharomyces cerevisiae may be regulated by the cyclin-dependent kinase (Cdk). To examine this hypothesis, we mutated all of the G1 cyclin genes in strains competent to form pseudohyphae. Interestingly, mutation of each G1 cyclin results in a different filamentation phenotype, varying from a significant defect in cln1/cln1 strains to enhancement of filament production in cln3/cln3 strains. cln1 cln2 double mutants are more defective in pseudohyphal development and haploid invasive growth than cln1 strains. FLO11 transcription, which correlates with the level of invasive growth, is low in cln1 cln2 mutants and high in grr1 cells (defective in proteolysis of Cln1,2), suggesting that Cln1,2/Cdks regulate the pseudohyphal transcriptional program. Epistasis analysis reveals that Cln1,2/Cdk and the filamentation MAP kinase pathway function in parallel in regulating filamentous and invasive growth. Cln1 and Cln2, but not Ste20 or Ste12, are responsible for most of the elevated FLO11 transcription in grr1 strains. Furthermore, phenotypic comparison of various filamentation mutants illustrates that cell elongation and invasion/cell-cell adhesion during filamentation are separable processes controlled by the pseudohyphal transcriptional program. Potential targets for G1 cyclin/Cdks during filamentous growth are discussed.
Myocardial Tension and Oxygen Uptake

Data obtained in 94 tests in nine anesthetized, thoracotomized dogs were re-examined to determine relationships among oxygen uptake per minute ( qO 2), cardiac frequency ( F ), mean aortic pressure ( P ), stroke volume ( V ), and heart weight ( G ). Statistical analysis supports the concept that during each systole qO2/G is empirically related most closely to the peak mechanical tension ( T ) developed by a spherical heart, in accord with the relationship qO2/G-b / F = aT , in which a and b are derived constants for each heart. Peak tension is half the product of the mean pressure and the radius (estimated from the stroke volume). Myocardial oxygen uptake is viewed as developing through a mechanical positive feedback mechanism which triggers the shortening of contractile elements. The number of such elements triggered in each beat determines the peak tension, the oxygen requirement of that beat, the resulting energy release, and the work. The oxygen costs of tension increase with the size of the heart since tension must be applied throughout the entire surface of each shell of contractile elements. Mechanical efficiency varies with the square of the stroke radius; it is not directly affected by mean aortic pressure or cardiac frequency. Factors affecting the all-or-none phenomenon, mobilization of tension, myocardial efficiency, the law of the heart, myocardial oxygen uptake, and the coronary flow are discussed in light of these findings.
The elliptic products of Jacobi and the theory of linear congruences

In the application of Elliptic Functions to the Theory of Numbers the two formulae of Jacobi are of great importance.
Curvature in Arabidopsis Inflorescence Stems Is Limited to the Region of Amyloplast Displacement

Gravitropic sensing in stems and stem-like organs is hypothesized to occur in the endodermis. However, since the endodermis runs the entire length of the stem, the precise site of gravisensing has been difficult to define. In this investigation of gravisensitivity in inflorescence stems of Arabidopsis, we positioned stems in a high gradient magnetic field (HGMF) on a rotating clinostat. Approximately 40% of the young, wild-type (WT) inflorescences, for all positions tested, curved toward the HGMF in the vicinity of the stem exposed to the field. In contrast, when the wedge was placed in the basal region of older inflorescence stems, no curvature was observed. As a control, the HGMF was applied to a starchless mutant, and 5% of the stems curved toward the field. Microscopy of the endodermis in the WT showed amyloplast displacement in the vicinity of the HGMF. Additional structural studies demonstrated that the basal region of WT stems experienced amyloplast displacement and, therefore, suggest this region is capable of gravity perception. However, increased lignification likely prevented curvature in the basal region. The lack of apical curvature after basal amyloplast displacement indicates that gravity perception in the base is not transmitted to the apex. Thus, these results provide evidence that the signal (and thus, response) resulting from perception in Arabidopsis inflorescence stems is spatially restricted.
Biodistribution of copper carboranyltetraphenylporphyrins in rodents bearing an isogeneic or human neoplasm.

The biodistributions of carborane-containing copper porphyrins, CuTCP and CuTCPH, have been studied previously in mice bearing subcutaneously implanted mammary carcinomas. We now report biodistributions of those porphyrins in Fischer 344 rats bearing intracranial and/or multiple subcutaneous isogeneic 9L gliosarcomas (9LGS). The porphyrin was given either by i.v. infusion or by multiple i.p. injections. When 190 mg CuTCPH/kg body weight was given to the rats by i.v. infusion, median tissue boron concentrations (microg/g) 3 days after the end of infusion were: 64 in subcutaneous tumor, 13 in intracranial tumor, 1 in blood and 3 in brain. When 450 mg CuTCPH/kg body weight was given to the rats by serial i.p. injections, the median concentrations (microg B/g) 4 days after the last injection were: 117 in subcutaneous tumor, 50 in intracranial tumor, 4 in blood, and 4 in brain. CuTCPH biodistribution was also studied in xenografts of the human malignant gliomas U87 and U373, and of the murine EMT-6 mammary carcinoma and the rat 9LGS, each grown subcutaneously in mice with severe combined immunodeficiency (SCIDs). In SCIDs, median boron concentrations (microg/g) 2 days after the last s.c. injection of a total of 190 mg CuTCPH/kg body weight were: 251 in U373, 33 in U87, <0.6 in blood and <0.5 in brain. Because there were such high boron levels in the U373, and because xenografted U373 is similar to spontaneous intracerebral human glioblastoma multiforme (GBM) microscopically, CuTCPH could prove useful as a boron carrier for boron neutron-capture therapy (BNCT) of GBM and of other human malignant gliomas.
Spanking and Child Development: We Know Enough Now to Stop Hitting Our Children

Spanking remains a common, if controversial, childrearing practice in the United States. In this article, I pair mounting research indicating that spanking is both ineffective and harmful with professional and human rights opinions disavowing the practice. I conclude that spanking is a form of violence against children that should no longer be a part of American childrearing.
Analysis of a swirl stabilized arcjet thruster

Viscous swirling flow through transonic converging-diverging nozzles (with and without centerbodies) is examined numerically. An implicit technique is used to solve the axisymmetric Thin Layer Naiver-Stokes equations. The effect of swirl and viscosity on low Reynolds number flows is shown by examining integral parameters and flowfield details.
Role of the locus ceruleus in baroreceptor regulation of supraoptic vasopressin neurons in the rat

The goal of this study was to identify the source of baroreceptor-related noradrenergic innervation of the diagonal band of Broca (DBB). Male Sprague-Dawley rats underwent sinoaortic denervation (S...
Implicit Integration of the Equations of Multibody Dynamics

Implicit integration approaches based on generalized coordinate-partitioning of the differential-algebraic equations of motion of multibody dynamics are presented. The methods developed are intended for simulation of stiff mechanical systems using the well-known Newmark integration method from structural dynamics and more recent implicit Runge-Kutta methods. Newmark integration formulas for second-order differential equations are first used to define independent generalized coordinates and their first time-derivative as functions of independent accelerations. The latter are determined as the solution of discretized equations obtained using the descriptor form of the equations of motion. Dependent variables in the formulation, including Lagrange multipliers, are determined to satisfy all the kinematic and kinetic equations of multibody dynamics. Next, the process is extended to implicit Runge-Kutta methods with variable step size and error control. The approach is illustrated by solving the constrained equations of motion for mechanical systems that exhibit stiff behavior. Results show that the approach is robust and has the capability to integrate differential-algebraic equations of motion for stiff multibody dynamic systems
Concomitant Hamiltonian and topological structures of extended magnetohydrodynamics

Abstract The paper describes the unique geometric properties of ideal magnetohydrodynamics (MHD), and demonstrates how such features are inherited by extended MHD, viz. models that incorporate two-fluid effects (the Hall term and electron inertia). The generalized helicities, and other geometric expressions for these models are presented in a topological context, emphasizing their universal facets. Some of the results presented include: the generalized Kelvin circulation theorems; the existence of two Lie-dragged 2-forms; and two concomitant helicities that can be studied via the Jones polynomial, which is widely utilized in Chern–Simons theory. The ensuing commonality is traced to the existence of an underlying Hamiltonian structure for all the extended MHD models, exemplified by the presence of a unique noncanonical Poisson bracket, and its associated energy.
A Sensory Integrative Approach for Children with Hearing Impairment: A case Study

The purpose of this paper is to demonstrate the potential use of a sensory integrative (SI) treatment approach in the treatment of hearing-impaired children with vestibular deficits. The association between falling, hearing impairment and vestibular dysfunction is discussed. A case study using SI with a hearing-impaired child is presented. The resultsof this preliminary investigation suggest that sensory integrative treatment may be useful in promoting compensation in hearing-impaired children with vestibular dysfunction.
Sampling Efficiency of the UC-VAC for Larva Populations of Hypera brunneipennis (Coleoptera: Curculionidae) in Weed-free and Weedy Alfalfa Communities

Efficiency of the UC-VAC suction sampler as a primary sampling tool for larva populations of Hypera brunneipennis (Boheman) was tested in weed-free and weedy alfalfa ( Medicago sativa L. ‘Moapa 69’) communities. Only a fraction of the actual larva population per 9.20.cm2 was recovered by the UC-VAC and differed between age classes. There were no significant differences in the performance of the UC-VAC between weed-free and weedy alfalfa with the exception of second instars in the second year of the study. There was an approximate 2-fold time savings for extracting larvae from vegetation using Berlese funnels in comparison with manual examination of alfalfa stems.
Assessing the distinguishable cluster approximation based on the triple bond-breaking in the nitrogen molecule

Obtaining the correct potential energy curves for the dissociation of multiple bonds is a challenging problem for ab initio methods which are affected by the choice of a spin-restricted reference function. Coupled cluster (CC) methods such as CCSD (coupled cluster singles and doubles model) and CCSD(T) (CCSD + perturbative triples) correctly predict the geometry and properties at equilibrium but the process of bond dissociation, particularly when more than one bond is simultaneously broken, is much more complicated. New modifications of CC theory suggest that the deleterious role of the reference function can be diminished, provided a particular subset of terms is retained in the CC equations. The Distinguishable Cluster (DC) approach of Kats and Manby [J. Chem. Phys. 139, 021102 (2013)], seemingly overcomes the deficiencies for some bond-dissociation problems and might be of use in quasi-degenerate situations in general. DC along with other approximate coupled cluster methods such as ACCD (approximate coupled cluster doubles), ACP-D45, ACP-D14, 2CC, and pCCSD(α, β) (all defined in text) falls under a category of methods that are basically obtained by the deletion of some quadratic terms in the double excitation amplitude equation for CCD/CCSD (coupled cluster doubles model/coupled cluster singles and doubles model). Here these approximate methods, particularly those based on the DC approach, are studied in detail for the nitrogen molecule bond-breaking. The N2 problem is further addressed with conventional single reference methods but based on spatial symmetry-broken restricted Hartree–Fock (HF) solutions to assess the use of these references for correlated calculations in the situation where CC methods using fully symmetry adapted SCF solutions fail. The distinguishable cluster method is generalized: 1) to different orbitals for different spins (unrestricted HF based DCD and DCSD), 2) by adding triples correction perturbatively (DCSD(T)) and iteratively (DCSDT-n), and 3) via an excited state approximation through the equation of motion (EOM) approach (EOM-DCD, EOM-DCSD). The EOM-CC method is used to identify lower-energy CC solutions to overcome singularities in the CC potential energy curves. It is also shown that UHF based CC and DC methods behave very similarly in bond-breaking of N2, and that using spatially broken but spin preserving SCF references makes the CCSD solutions better than those for DCSD.
Susceptibility of the guinea pig to action of alloxan as compared with the rat.

SummaryThe parentera1 administration of various dosages of alloxan, up to those which were fatal, failed to produce diabetes in guinea pigs. Neither glycosuria nor hyper- glycemia was observed., Animals deficient in ascorbic acid, partially pancreatectomised or starved prior to alloxan administration, also failed to develop diabetes, although starvation apparently increased the toxicity of alloxan.The guinea pig is. much more resistant to the diabetogenic and the toxic action of alloxan than is the rat, and the pancreatic islet cells appear no more susceptible to alloxan than the cells of several other tissues.
A Dynamic Partition Sequential Pattern Mining Algorithm

When mining sequential patterns among vast data,since huge amounts of candidate sequences are generated and the database is scanned for so many times,the memory is limited and the searching efficiency is low. In order to solve the problems,a dynamic partition sequential pattern mining algorithm (DPSPM) was put forward based on shared-nothing distributed environment. The I/O cost,communication cost and memory cost were reduced by data distributing,allotting function and dynamic list,the efficiency of algorithm is improved by asynchronous process. The experiment result demonstrates that DPSPM has high searching efficiency in the case of large database and low support threshold.
Pilot Study on the Mechanism of CNE Cell Apoptosis Induced by Indole-3-carbinol

BACKGROUND AND AIM: To study the effect of indole-3-carbinol(I3C) in CNE cells as well as the underlying mechanisms.MATERIALS AND METHODS: The inhibition of cell proliferation was assayed by WST-1 agent,and the apoptosis was shown with Hochest 33258 and TUNEL staining.To study the mechanism of apoptosis,the expression of the cleaved caspase-9 and the cleaved caspase-3 were detected with western immublotting assay.RESULTS: I3C could inhibit the proliferation of CNE cells and apoptosis could be induced by I3C in a dose-dependent manner.Furthermore,the expressions of cleaved caspase-9 and cleaved caspase-3 appeared to be increased significantly as compared with those of the control.CONCLUSION: I3C could induce apoptosis of CNE cells dose-dependently,and caspase-9 and caspase-3 pathways might be involved.
Clinical training in the rural setting: using photovoice to understand student experiences.

INTRODUCTION Attracting and retaining healthcare providers in rural locations in the USA has been an issue for more than two decades. In response to this need, many health sciences education institutions in the USA have developed special programs to encourage students to become healthcare providers in rural locations. One approach is the use of community-based education experiences through rural track programs. Rural track programs seek to address the shortage of healthcare providers working in rural areas by nurturing and educating students interested in rural practice and primary care. Such programs serve both medical students and students of other health professions. Yet, little is known about student experiences in rural track programs. As such, this study aimed to generate discourse on student experiences in the rural training environment and gain insight into the impact of rural environments on student learning. METHODS An exploratory qualitative analysis of medical and physician assistant student experiences in two rural medical education training programs was conducted using the photovoice methodology. Photovoice is a participatory research method combining photography with participant commentary and focus groups. RESULTS Twenty-two third-year medical and six second-year physician assistant students participated in the study. Students noted that in their rural sites the learning environment extended beyond direct clinical teaching in four primary ways: (1) relationships with clinical faculty translated to a sense of meaningful participation in healthcare teams; (2) connections with community members outside of clinical settings led to increased awareness of healthcare concerns; (3) rural settings provided important space to reflect on their experiences; and (4) the importance of infrastructure was highlighted. Students also believed that diversity of occupation, education, attitude, and perception of medical care impact learning in rural environments. CONCLUSIONS The photovoice participatory research methodology allowed for a deeper understanding of the aspects of the rural training experience that resonated most among students in real time, using visual representations of students' lived experiences as defined by the students.
Calcium Revisited: New Insights Into the Molecular Basis of Long-QT Syndrome.

The first clinical description of long-QT syndrome (LQTS) occurred in 1957 when Drs Anton Jervell and Fred Lange-Nielsen postulated that syncopal/seizure episodes and high propensity for sudden cardiac death (SCD) observed in a subset of children with sensorineural deafness and otherwise unexplained heart rate–corrected QT interval prolongation on ECG stemmed from a novel congenital disorder.1 This was followed by independent descriptions of a syndrome characterized by a cardiac-only phenotype consisting of prolonged QT intervals and an increased risk for syncope, seizures, and SCD in the absence of sensorineural deafness by Drs Cesarino Romano and Owen Ward, in 1963 and 1964, respectively.2,3 During the past 5 decades, insights gleamed from a multitude of clinical, epidemiological, and molecular studies have demonstrated that LQTS is a collection of not only genetically and phenotypically diverse disorders of cardiac repolarization that encompasses the aforementioned predominantly autosomal-dominant, nonsyndromic Romano–Ward syndrome now simply referred to as LQTS4 and autosomal-recessive, multisystem, Jervell–Lange Nielsen syndrome but also exceedingly rare multisystem LQTS subtypes such as Timothy syndrome (TS) characterized by QT prolongation and an increased risk of SCD along with an array of extracardiac manifestations. Although mutations in calcium (Ca2+)-handling proteins, including the CACNA1C -encoded L-type Ca2+ channel (LTCC), RYR2 -encoded ryanodine receptor-2 intracellular calcium release channel (RyR2), and many other auxiliary interacting proteins, are central to the pathogenesis of inherited cardiac arrhythmia syndromes, such as catecholaminergic ventricular tachycardia and Brugada syndrome, until recently, the contribution of dysfunctional Ca2+ handling to the pathogenesis of LQTS was limited to the extremely rare and highly lethal multisystem TS. However, the unexpected recent discoveries of multiple nonsyndromic LQTS-causative mutations in CACNA1C ,5–7 syndromic LQTS-causative mutations in CALM1-3 -encoded Calmodulin8,9 and TRDN -encoded Triadin,10 and common genetic variation at …
Peptide-Amphiphile Induction of α-Helical Molecular Architecture and Interaction with Biomaterial Surfaces

Controlling cell adhesion to polymer substrates is one of the important issues in tissue engineering, and includes the ability to direct specific cell types to proliferate, migrate, and express normal physiological behaviors, in order to yield a defined cellular architecture [1], Engineering bioactive, conformationally constrained peptides onto biomaterial surfaces could satisfy the above criteria and hence improve biocompatibility. Our laboratory previously demonstrated that linking lipid tails to peptides enables them to self-assemble into biomimetic films with a highly organized interface, and perhaps more importantly, enhances their ability to assume well-defined secondary and tertiary conformations [2–4]. These peptide-amhiphiles effectively promote a variety of cell activities [2]. In the present study, novel peptide-amphiphiles that have the potential to form α-helical structure combined with an amino acid sequence from the angiogenesis-inducing region of SPARC have been constructed. The peptide sequence 21r, Lys-Ala-(Glu-Ile-Glu-Ala-Leu-Lys-Ala)2-Tyr-Lys-Gly-His-Lys, was lipidated with one of the three “tails” listed below and characterized.
The evolutionary ecology of molecular replicators

By reasonable criteria, life on the Earth consists mainly of molecular replicators. These include viruses, transposons, transpovirons, coviruses and many more, with continuous new discoveries like Sputnik Virophage. Their study is inherently multidisciplinary, spanning microbiology, genetics, immunology and evolutionary theory, and the current view is that taking a unified approach has great power and promise. We support this with a new, unified, model of their evolutionary ecology, using contemporary evolutionary theory coupling the Price equation with game theory, studying the consequences of the molecular replicators' promiscuous use of each others' gene products for their natural history and evolutionary ecology. Even at this simple expository level, we can make a firm prediction of a new class of replicators exploiting viruses such as lentiviruses like SIVs, a family which includes HIV: these have been explicitly stated in the primary literature to be non-existent. Closely connected to this departure is the view that multicellular organism immunology is more about the management of chronic infections rather than the elimination of acute ones and new understandings emerging are changing our view of the kind of theatre we ourselves provide for the evolutionary play of molecular replicators. This study adds molecular replicators to bacteria in the emerging field of sociomicrobiology.
Metabolic and Growth Rate Alterations in Lymphoblastic Cell Lines Discriminate Between Down Syndrome and Alzheimer's Disease.

Background Deficits in mitochondrial function and oxidative stress play pivotal roles in Down syndrome (DS) and Alzheimer's disease (AD) and these alterations in mitochondria occur systemically in both conditions. Objective We hypothesized that peripheral cells of elder subjects with DS exhibit disease-specific and dementia-specific metabolic features. To test this, we performed a comprehensive analysis of energy metabolism in lymphoblastic-cell-lines (LCLs) derived from subjects belonging to four groups: DS-with-dementia (DSAD), DS-without-dementia (DS), sporadic AD, and age-matched controls. Methods LCLs were studied under regular or minimal feeding regimes with galactose or glucose as primary carbohydrate sources. We assessed metabolism under glycolysis or oxidative phosphorylation by quantifying cell viability, oxidative stress, ATP levels, mitochondrial membrane potential (MMP), mitochondrial calcium uptake, and autophagy. Results DS and DSAD LCLs showed slower growth rates under minimal feeding. DS LCLs mainly dependent on mitochondrial respiration exhibited significantly slower growth and higher levels of oxidative stress compared to other groups. While ATP levels (under mitochondrial inhibitors) and mitochondrial calcium uptake were significantly reduced in DSAD and AD cells, MMP was decreased in DS, DSAD, and AD LCLs. Finally, DS LCLs showed markedly reduced levels of the autophagy marker LC3-II, underscoring the close association between metabolic dysfunction and impaired autophagy in DS. Conclusion There are significant mitochondrial functional changes in LCLs derived from DS, DSAD, and AD patients. Several parameters analyzed were consistently different between DS, DSAD, and AD lines suggesting that metabolic indicators between LCL groups may be utilized as biomarkers of disease progression and/or treatment outcomes.
Stability of model predictive control under perturbations

Abstract Exponential stability and asymptotic perturbed stability results are derived for nonlinear discrete-time systems. Some related results are available in the literature but proofs for the discrete-time case are difficult to find. Our motivation for obtaining these results is to determine conditions under which discrete-time nonlinear model predictive control is stabilizing in the face of perturbations. This problem has particular relevance when output (rather than state) feedback is used. A nonlinear state estimator is then required to reconstruct the state and it is necessary to identify the class of reconstruction errors for which the cascaded estimator/controller assembly is stabilizing.