cssi/SciSciGPT-SciSciNet huggingface dataset:
Effective magnetic anisotropy vector field

An effective anisotropy vector field that can be treated as an effective external field has been formulated for uniaxial anisotropies with n-fold symmetry within the plane containing the main axis. A simple method for obtaining the effective field for the two-fold symmetry uniaxial anisotropy and the calculated result according to the method are presented. Then the extension to n-fold symmetry anisotropies is given and the calculated results for four- and six-fold symmetry cases are demonstrated. The tips of those vector fields are found to trace hypocycloids moving oppositely with the rotation of magnetization. The newly introduced effective anisotropy vector field may make a new tool in various analysis of magnetization processes and help understand the effect of anisotropy on magnetization visually.
Assessment of the results from the phase I/II boron neutron capture therapy trials at the Brookhaven National Laboratory from a clinician's point of view.

Boron neutron capture therapy (BNCT) represents a promising modality for a relatively selective radiation dose delivery to the tumor tissue. The key to effective BNCT of tumors such as glioblastoma multiforme (GBM) is the homogeneous preferential accumulation of10B in the tumor, including the infiltrating GBM cells, as compared to that in the vital structures of the normal brain. Provided that sufficiently high tumor10B concentration (∼109 boron-10 atoms/cell) and an adequate thermal neutron fluence (∼ 109 neutrons/cm2) are achieved, it is the ratio of the10B concentration in tumor cells to that in the normal brain cells and the blood that will largely determine the therapeutic gain of BNCT.
Summation of responding to CSs and an excitatory test context

The influence of test-trial delay of CS onset in obtaining response summation of an excitatory CS and an independently conditioned context was investigated. Water-deprived rats were given tone-shock and click-shock pairings in the training context and unsignaled footshocks in the test context. Durations of lick suppression in response to the tone (Test 1) and the click (Test 2) were then assessed in the test context. Licking was more suppressed when CS onset occurred early in the test session (e.g., 0 sec) than when it occurred later in the test session (e.g., 300 sec). The results from control groups that had received shock in an irrelevant context rather than the test context indicated that this effect was due to fear of the test context rather than diffuse, nonassociative fear. With onset of the clicks early in the test session on the second test day, response summation of the test context with the clicks was observed. This suggests that appreciable spontaneous recovery had occurred from any test-context extinction that took place on the first test day. We conclude that early onset of the CS on the test trial favors response summation of CSs and test context.
An oviductal fluid glycoprotein associated with ovulated mouse ova and early embryos

This study documents a molecular change in the murine ovum related to its exposure to oviductal fluid. Wheat germ agglutinin (WGA) identifies a 215-kDa glycoprotein band (GP215) that is associated with ovulated oocytes and early embryos obtained from the oviduct, but is absent from preovulatory oocytes. GP215 is present in ovarian bursal fluid, oviductal fluid, oviductal epithelial cell extracts, and medium conditioned by oviductal tissue in vitro. Preovulatory oocytes acquire GP215 after in vitro incubation in ovarian bursal fluid. Thus, it appears likely that GP215 is secreted by the oviductal epithelium and becomes intimately associated with the ovum following ovulation.
Bone disease after renal transplantation

In light of greatly improved long-term patient and graft survival after renal transplantation, improving other clinical outcomes such as risk of fracture and cardiovascular disease is of paramount importance. After renal transplantation, a large percentage of patients lose bone. This loss of bone results from a combination of factors that include pre-existing renal osteodystrophy, immunosuppressive therapy, and the effects of chronically reduced renal function after transplantation. In addition to low bone volume, histological abnormalities include decreased bone turnover and defective mineralization. Low bone volume and low bone turnover were recently shown to be associated with cardiovascular calcifications, highlighting specific challenges for medical therapy and the need to prevent low bone turnover in the pretransplant patient. This Review discusses changes in bone histology and mineral metabolism that are associated with renal transplantation and the effects of these changes on clinical outcomes such as fractures and cardiovascular calcifications. Therapeutic modalities are evaluated based on our understanding of bone histology.
The Behavioral Approach in Political Science: Epitaph for a Monument to a Successful Protest

Perhaps the most striking characteristic of the “behavioral approach” in political science is the ambiguity of the term itself, and of its synonym “political behavior.” The behavioral approach, in fact, is rather like the Loch Ness monster: one can say with considerable confidence what it is not, but it is difficult to say what it is. Judging from newspaper reports that appear from time to time, particularly just before the summer tourist season, I judge that the monster of Loch Ness is not Moby Dick, nor my daughter's goldfish that disappeared down the drain some ten years ago, nor even a misplaced American eight heading for the Henley Regatta. In the same spirit, I judge that the behavioral approach is not that of the speculative philosopher, the historian, the legalist, or the moralist. What, then, is it? Indeed, does it actually exist?Although I do not profess to know of the full history of the behavioral approach, a little investigation reveals that confusing and even contradictory interpretations have marked its appearance from the beginning. The first sightings in the roily waters of political science of the phenomenon variously called political behavioral approach, or behavioral(ist) research, evidently occurred in the 1920s. The term “political behavior,” it seems, was used by American political scientists from the First World War onward. The honor of first adopting the term as a book title seems to belong, however, not to a political scientist but to the American journalist Prank Kent, who published a book in 1928 entitled Political Behavior, The Heretofore Unwritten Laws, Customs, and Principles of Politics as Practised in the United States. To Kent, the study of political behavior meant the cynical “realism” of the tough-minded newspaperman who reports the way things “really” happen and not the way they're supposed to happen. This meaning, I may say, is often implied even today. However, Herbert Tingsten rescued the term for political science in 1937 by publishing his path-breaking Political Behavior: Studies in Election Statistic. Despite the fact that Tingsten was a Swede, and his work dealt with European elections, the term became increasingly identified with American political science.
Estimation of linear models for field experiments

General mixed linear models for experiments conducted over a series of sltes and/or years are described. The ordinary least squares (OLS) estlmator is simple to compute, but is not the best unbiased estimator. Also, the usuaL formula for the varlance of the OLS estimator is not correct and seriously underestimates the true variance. The best linear unbiased estimator is the generalized least squares (GLS) estimator. However, t requires an inversion of the variance-covariance matrix V, whlch is usually of large dimension. Also, in practice, V is unknown. We presented an estlmator [Vcirc] of the matrix V using the estimators of variance components [for sites, blocks (sites), etc.]. We also presented a simple transformation of the data, such that an ordinary least squares regression of the transformed data gives the estimated generalized least squares (EGLS) estimator. The standard errors obtained from the transformed regression serve as asymptotic standard errors of the EGLS estimators. We also established ...
Prediction of melt viscosity flow curves at various temperatures for some olefin polymers and copolymers

A knowledge of the variation of melt viscosity of thermoplastic polymers with both shear rate and temperature is of considerable importance to plastics engineers as well as to polymer rheologists. The actual measurement of melt viscosity at a large number of temperatures and shear rates is frequently a tedious and time-consuming task. A technique has been developed, based upon the applicability of shear rate-temperature superposition, for predicting the flow curves of a number of olefin polymers and copolymers at various temperatures from experimental data obtained at one temperature for the material in question. The experimental validity for superimposing log shear stress—log shear rate curves at different temperatures along the log shear rate axis has been established for both high and low density polyethylenes, polypropylene, polybutene-1, and poly (ethylene vinyl acetate) copolymers. The temperature dependence of the resultant shift factors has been determined for each system, and the method of utilizing this information to predict viscosities as a function of temperature and shear rate is discussed.
The development of group scores in the prediction of group performance

Summary A rationale is presented for combining individual scores to form group scores in order to predict the performance of task-oriented groups. The rationale, based on job analysis data, is applied to the activities required of antiaircraft artillery gun crews. From this application, specific hypotheses are advanced concerning the kind of scores that will be predictive. These hypotheses are tested in two samples, each consisting of sixteen gun crews. Inconsistencies in results for the two samples are discussed, and the implications for crew-assembly procedures indicated. It is concluded that the rationale offers a reasonable starting point for a group psychometric.
Effects of chemical and surgical lesions on levels of chromatographically identified enkephalin-like peptides in rat hippocampus

Abstract The present study quantities the content of Met- and Leu-enkephalin in the rat hippocampus, and provides information on the localization of the enkephalins within the hippocampal neuronal circuitry. Several enkephalins were identified in rat hippocampus, two of which are shown to be Met- and Leu-enkephalin. The levels of these enkephalins, and of other unidentified enkephalin-related peptides, were not depleted by intrahippocampal colchicine, which destroyed the great majority of the hippocampal granule cells and the associated mossy fiber pathway. Entorhinal cortical lesions ablating the perforant pathway input to the hippocampus also did not significantly lower enkephalin levels in the hippocampus. Unilateral fimbrial transection caused a significant bilateral increase in both Met- and Leu-enkephalin levels. This may result from loss of a stimulatory input to putative enkephalin containing interneurons within the hippocampus. The extents of all lesions were verified histologically in hippocampi used for biochemical analysis. No evidence was seen for the presence of enkephalin in the perforant pathway, not in nerve fibers in the fimbria/fornix, which provide the other main source of hippocampal efferents. The enkephalins are likely to be intrinsicc to the hippocampus, in which neuronal cell bodies containing enkephalin-like immunoreactivity have been extensively reported.
Role of the hippocampus in Nav1.6 (Scn8a) mediated seizure resistance

SCN1A mutations are the main cause of the epilepsy disorders Dravet syndrome (DS) and genetic epilepsy with febrile seizures plus (GEFS+). Mutations that reduce the activity of the mouse Scn8a gene, in contrast, are found to confer seizure resistance and extend the lifespan of mouse models of DS and GEFS+. To investigate the mechanism by which reduced Scn8a expression confers seizure resistance, we induced interictal-like burst discharges in hippocampal slices of heterozygous Scn8a null mice (Scn8a(med/+)) with elevated extracellular potassium. Scn8a(med/+) mutants exhibited reduced epileptiform burst discharge activity after P20, indicating an age-dependent increased threshold for induction of epileptiform discharges. Scn8a deficiency also reduced the occurrence of burst discharges in a GEFS+ mouse model (Scn1a(R1648H/+)). There was no detectable change in the expression levels of Scn1a (Nav1.1) or Scn2a (Nav1.2) in the hippocampus of adult Scn8a(med/+) mutants. To determine whether the increased seizure resistance associated with reduced Scn8a expression was due to alterations that occurred during development, we examined the effect of deleting Scn8a in adult mice. Global Cre-mediated deletion of a heterozygous floxed Scn8a allele in adult mice was found to increase thresholds to chemically and electrically induced seizures. Finally, knockdown of Scn8a gene expression in the adult hippocampus via lentiviral Cre injection resulted in a reduction in the number of EEG-confirmed seizures following the administration of picrotoxin. Our results identify the hippocampus as an important structure in the mediation of Scn8a-dependent seizure protection and suggest that selective targeting of Scn8a activity might be efficacious in patients with epilepsy.
An entity maintenance and connection service for sensor networks

In this paper, we present a middleware architecture for coordination services in sensor networks that facilitates interaction between groups of sensors which monitor different environmental events. It sits on top of the native routing infrastructure and exports the abstraction of mobile communication endpoints maintained at the locations of such events. A single logical destination is created and maintained for every environmental event of interest. Such destinations are uniquely labeled and can be used for communication by application-level algorithms for coordination and sensory data management between the different event locales. For example, they may facilitate coordination, in a distributed intrusion scenario, among nodes in the vicinity of the intruders.We evaluate our middleware architecture using GloMoSim, a wireless network simulator. Our results illustrate the success of our architecture in maintaining event-related communication endpoints. We provide an analysis of how architectural and network dependent parameters affect our performance. Additionally we provide a proof of concept implementation on a real sensor network testbed (Berkeley's MICA Motes).
Review of three-dimensional mathematical modeling of glass melting

Abstract Incentives for simulating flow patterns and heat transfer in glass melting furnaces are discussed, and model idealizations, input data needs and desired outputs are reviewed. Current three-dimensional mathematical models for simulating flow and heat transfer processes in glass melting furnaces are summarized and some sample results for flow and thermal structures are presented. Advantages and disadvantages of physical and mathematical modeling of glass melting furnaces are compared. Data needed to resolve some remaining technical issues are identified. Closing remarks are included on some remaining challenges, such as effective presentation of the immense amount of computer-generated data for the furnace designer/operator and interpretation of the results for the purpose of improving glass quality and productivity.
Magnetic Moment of the Free Muon

The magnetic moment of the positive $\ensuremath{\mu}$ meson has been measured in several target materials by a magnetic resonance technique. Muons were brought to rest with their spins parallel to a magnetic field. A radio-frequency pulse was applied to effect a spin reorientation which was detected by counting the decay electrons emerging after the pulse in a fixed direction. Results are expressed in terms of a $g$ factor which for a spin 1/2 particle is the ratio of the actual moment to $\frac{e\ensuremath{\hbar}}{2{m}_{\ensuremath{\mu}}c}$. The most accurate result obtained in a CH${\mathrm{Br}}_{3}$ target, is that $g=2(1.0026\ifmmode\pm\else\textpm\fi{}0.0009)$ compared to the theoretical prediction of $g=2(1.0012)$. Less accurate measurements yielded $g=2.005\ifmmode\pm\else\textpm\fi{}0.005$ in a copper target and $g=2.00\ifmmode\pm\else\textpm\fi{}0.01$ in a lead target.
US Policy and the Nuclear Weapons Ambitions of the “Axis of Evil” Countries*

This article examines US policy as it pertains to the nuclear weapons objectives of what the Bush administration identified as the countries making up the “axis of evil,” pre-war Iraq, Iran and North Korea. Having drawn the same conclusion as that appearing in the 2000 report of the Project for the New American Century, which alleged the involvement of these countries in illicit activities relating to nuclear weapons, the Bush administration initiated an overtly hostile and accusatory policy toward each of these nations after 9/11.Undeterred by the paucity of evidence and the failure to find a nuclear weapons program (or any weapons of mass destruction) in Iraq, the Bush administration has remained relentlessly focused on the nuclear weapons ambitions of North Korea and Iran, all the while ignoring or minimizing diplomatic efforts that are not hegemonic and confrontational. This paper stresses that for the past several years the Bush administration has not hesitated in using questionable and uncertain inf...
Electronic effects in asymmetric hydroboration

Abstract To determine whether electronic effects are operative in asymmetric hydroboration, a series of para -substituted 2-aryl-1-propenes were prepared and reacted with four asymmetric borane reagents. A significant correlation between the electronic nature of the para -substituent and the degree of asymmetric induction was observed only for a chloroborane–ether complex, not for any of several simple alkylboranes. A quantitative analysis of the relative reactivities is also given.
Molecular genetics of Oguchi disease, fundus albipunctatus, and other forms of stationary night blindness: LVII Edward Jackson Memorial Lecture.

Abstract PURPOSE: To compare the clinical findings of the various forms of stationary night blindness caused by mutations in identified genes encoding proteins of photoreceptors or the retinal pigment epithelium. METHODS: Review of the visual acuities, visual fields, fundi, dark-adaptation curves, and electroretinograms from patients with stationary night blindness caused by mutations in the genes RHO, GNAT1, PDE6B, RHOK, SAG, RDH5, and CACNA1F , respectively encoding rhodopsin, the α subunit of rod transducin, the β subunit of rod cGMP-phosphodiesterase, rhodopsin kinase, arrestin, 11- cis retinol dehydrogenase, and a retinal L-type calcium channel. RESULTS: In the evaluated forms of stationary night blindness, the time course of dark adaptation and the characteristics of the electroretinogram indicate that rod photoreceptors are present and that they function, although abnormally. In night blindness resulting from defects in rhodopsin, the α subunit of rod transducin, or the β subunit of rod cGMP phosphodiesterase, rod photoreceptors respond only to light intensities far brighter than normal, and the sensitivity of rods to light is similar to that of normal individuals who are not dark adapted. In fundus albipunctatus and in Oguchi disease, the rod photoreceptors can achieve normal sensitivity to dim light but only after 2 or more hours of dark adaptation, compared with approximately 0.5 hours for normal individuals. In each of these forms of stationary night blindness, the poor rod sensitivity and the time course of dark adaptation correlate with the known or presumed physiologic abnormalities caused by the identified gene defects. Patients with some forms of stationary night blindness, such as fundus albipunctatus and Oguchi disease, may develop degeneration of the retina leading to severe loss of vision in later life. CONCLUSIONS: The identification of the mutant genes causing forms of stationary night blindness refines the classification of these diseases and enhances our understanding of the underlying physiologic defects. Ophthalmologists must be aware that although these diseases are traditionally categorized as "stationary," some of them lead to reduced visual acuity or constricted visual fields, especially in older patients. Efforts to develop therapies for these diseases should concentrate on these more severe forms.
236 PHARMACOKINETICS OF AMIKACIN IN CHILDREN WITH MALIGNANCIES

Amikacin is an aminoglycoside antibiotic that is effective against gram negative bacilli which are resistant to other aminoglycoside antibiotics. Pharmacokinetic data of amikacin in pediatric patients are scant. The pharmacokinetics of amikacin were evaluated in 30 hospitalized children (5 to 14 years of age) with malignancies. Children receiving 15 or 20 mg/kg/24 hr administered every 8 to 6 hours, respectively had peak serum concentrations of 16.9±3.67 μg/ml (mean ± SD) at the end of a one hour infusion. Six and 8 hour serum concentrations were 1.27±1.26 and 0.64±0.92 μg/ml, respectively. The t½ was 78±43.8 minutes and the total clearance was 133±43 ml/min/1.73 m2. The mean volume of distribution was 0.26±0.08 1/kg. No accumulation of amikacin was noted and no side effects occurred. A 9% inactivation of amikacin occurred when incubated in normal donor sera at 37°C for 72 hours with varying concentrations of ticarcillin. Due to the rapid renal clearance and short half life of amikacin in these children, the currently recommended dose of amikacin should be increased and the frequency of administration shortened.
Community integration after burn injuries

Evaluation of community integration is a meaningful outcome criterion after major burn injury. The Community Integration Questionnaire (CIQ) was administered to 463 individuals with major burn injuries. The CIQ results in Total, Home Integration, Social Integration, and Productivity scores. The purposes of this study were to determine change in CIQ scores over time and what burn injury and demographic factors predict CIQ scores. The CIQ scores did not change significantly from 6 to 12 to 24 months postburn injury. Home integration scores were best predicted by sex and living situation; Social Integration scores by marital status; and Productivity scores by functional outcome, burn severity, age, and preburn work factors. The data demonstrate that individuals with burn injuries have significant difficulties with community integration due to burn and nonburn related factors. CIQ scores did not improve over time but improvement may have occurred before the initial 6-month postburn injury follow-up in this study.
Understanding Prosocial Behavior: The Impact of Empathy and Gender Among African American Adolescents

Although prosocial behavior in adolescence is associated with many positive outcomes, few studies have examined the factors that contribute to the development of prosocial behaviors. This study examines empathy and gender as predictors of prosocial behavior among African American early adolescents. Results revealed a significant main effect for empathy, as well as an interaction between empathy and gender in predicting prosocial behavior. In general, youth with more empathy reported more prosocial behavior, and this effect was more pronounced for males than females. These findings suggest that the ability to understand another's perspective may be important in the development and expression of prosocial behaviors, particularly among males.
Cobalt Limitation of Growth and Mercury Methylation in Sulfate-Reducing Bacteria

Sulfate-reducing bacteria (SRB) have been identified as the primary organisms responsible for monomethylmercury (MeHg) production in aquatic environments, but little is known of the physiology and biochemistry of mercury (Hg) methylation. Corrinoid compounds have been implicated in enzymatic Hg methylation, although recent experiments with a vitamin B12 inhibitor indicated that incomplete-oxidizing SRB likely do not use a corrinoid-enzyme for Hg methylation, whereas experiments with complete-oxidizing SRB were inconclusive due to overall growth limitation. Here we explore the role of corrinoid-containing methyltransferases, which contain a cobalt-reactive center, in Hg methylation. To this end, we performed cobalt-limitation experiments on two SRB strains: Desulfococcus multivorans, a complete-oxidizer that uses the acetyl–CoA pathway for major carbon metabolism, and Desulfovibrio africanus, an incomplete-oxidizer that does not contain the acetyl–CoA pathway. Cultures of D. multivorans grown with no direc...
Liquid/liquid interface polymerized porphyrin membranes displaying size-selective molecular and ionic permeability

Thin polymeric membranes have been formed by liquid/liquid interfacial copolymerization of a sterically demanding tetraphenylporphyrin derivative having reactive phenol substituents and a second porphyrin having reactive acid chloride groups. The out-of-plane steric demand is created by 3,5-hexoxyphenyl groups positioned at two of the four meso carbons of the porphyrin ring. The bulky substituents were designed to create local pockets and extended pores within the resulting ester-linked copolymer. Quantitative measures of molecular and ionic transport were obtained by placing membranes over microelectrodes and recording voltammetric responses from redox-active probes. The membranes were found to be permeable to small molecules and ions, but blocking toward larger ones, displaying a sharp size cutoff at a probe diameter of ca. 3.5 A. Molecular transport can be modulated by axially ligating pore-blocking moieties to available porphyrin metal centers.
ERAAP Synergizes with MHC Class I Molecules to Make the Final Cut in the Antigenic Peptide Precursors in the Endoplasmic Reticulum

The major histocompatibility complex class I molecules display peptides (pMHC I) on the cell surface for immune surveillance by CD8+ T cells. These peptides are generated by proteolysis of intracellular polypeptides by the proteasome in the cytoplasm and then in the endoplasmic reticulum (ER) by the ER aminopeptidase associated with antigen processing (ERAAP). To define the unknown mechanism of ERAAP function in vivo, we analyzed naturally processed peptides in cells with or without appropriate MHC I and ERAAP. In the absence of MHC I, ERAAP degraded the antigenic precursors in the ER. However, MHC I molecules could bind proteolytic intermediates and were essential for generation of the final peptide by ERAAP. Thus, ERAAP synergizes with MHC I to generate the final pMHC I repertoire.
Organizing hypocrisy: : providing legal accountability for human rights violations in areas of limited statehood

In recent years, courts in the Democratic Republic of Congo (DR Congo) have produced some of the most progressive judicial decisions against perpetrators of gender violence of anywhere in the world. Yet, DR Congo is often described as the archetypal collapsed state. This article uses a case study of domestic courts in Eastern DR Congo to analyze how and why complex functions of domestic governance—such as the production of frequent and high-quality judicial decisions by domestic courts—are able to persist, even flourish, in an area where the state is characterized by extreme fragility and weakness. I argue that, rather than a decoupling of law and practice as previous approaches might predict, state fragility in DR Congo has created openings for domestic and transnational actors to exert direct influence over judicial processes at multiple levels of governance. The involvement of external actors in the domestic authority structures of states has resulted in surprisingly progressive human rights outcomes in certain issue areas. However, the article also documents some of the unintended consequences of human rights developments that occur at the very peripheries of broader state-building projects.
“I Know You Are But What Am I?!”: Neural Bases of Self-and Social Knowledge Retrieval in Children and Adults

Previous neuroimaging research with adults suggests that the medial prefrontal cortex (MPFC) and the medial posterior parietal cortex (MPPC) are engaged during self-knowledge retrieval processes. However, this has yet to be assessed in a developmental sample. Twelve children and 12 adults (average age = 10.2 and 26.1 years, respectively) reported whether short phrases described themselves or a highly familiar other (Harry Potter) while undergoing functional magnetic resonance imaging. In both children and adults, the MPFC was relatively more active during self-than social knowledge retrieval, and the MPPC was relatively more active during social than self-knowledge retrieval. Direct comparisons between children and adults indicated that children activated the MPFC during self-knowledge retrieval to a much greater extent than adults. The particular regions of the MPPC involved varied between the two groups, with the posterior precuneus engaged by adults, but the anterior precuneus and posterior cingulate engaged by children. Only children activated the MPFC significantly above baseline during self-knowledge retrieval. Implications for social cognitive development and the processing functions performed by the MPFC are discussed.
Saccular otolith mass asymmetry in adult flatfishes

A dimensionless measure of otolith mass asymmetry, χ, was calculated as the difference between the masses of the right and left paired otoliths divided by average otolith mass. Saccular otolith mass asymmetry was studied in eight flatfish species (110 otolith pairs) and compared with data from a previously published study on roundfishes. As in the case of symmetrical fishes, the absolute value of χin flatfishes does not depend on fish length and otolith growth rate, although otolith mass and the absolute value of otolith mass difference are correlated with fish length. The values of χwere between −0·2 and +0·2 in 96·4% of flatfishes studied. The mean ±s.e. value of χin flatfishes was significantly larger than in standard bilaterally symmetrical marine fishes (‘roundfishes’), respectively 0·070 ± 0·006 and 0·040 ± 0·006. The most prominent distinction is the existence of downside prevalence of saccular otolith mass in flatfishes, which contrasts with no right–left prevalence in roundfishes found in a previous study. In the right-eyed flatfishes (Soleidae), the left saccular otoliths are heavier than the right otoliths. In the left-eyed flatfishes (Bothidae and Citharidae), the right saccular otoliths are heavier than the left otoliths. Not all flatfishes, however, fit in this design: 11·8% of flatfishes studied had the heavier saccular otoliths in the upside labyrinth and 5·4% of flatfishes had no otolith mass asymmetry (within the accuracy of the analysis). At the same time, the more mobile flatfishes (bothids and citharids) have more symmetrical and, hence, more precisely organized saccular otolith organs than the bottom-associated flatfishes (soleids). It is possible to assume that the value of the otolith asymmetry is not only correlated with flatfish placement in a particular family, or position of eyes, but also may correlate with general aspects of their ecology. Mathematical modelling indicated that for most flatfishes one-side saccular prevalence had no substantial significance for sound processing. On the other hand, calculations showed that 49% of flatfishes (but only 14·5% of roundfishes) have |χ| which exceed the critical level and, in principle, could sense the difference between the static displacement of the large and small paired otoliths. At that, the number of the soleids that could sense this difference is greater than the number of the bothids and citharids, 84 and 27%, respectively.
Calmodulin-sensitive adenylyl cyclases mediate AVP-dependent cAMP production and Cl− secretion by human autosomal dominant polycystic kidney cells

In autosomal dominant polycystic kidney disease (ADPKD), binding of AVP to the V2 receptor (V2R) increases cAMP and accelerates cyst growth by stimulating cell proliferation and Cl−-dependent fluid...
Influence of the Eden Alternative on the functional status of nursing home residents

The Eden Alternative™ was initiated to reduce feelings of loneliness, boredom, and helplessness among nursing home residents through interactions with plants, animals, and children in their environment. This study assessed the effects of the Eden Alternative on residents' physical, mental, emotional, and social function. Data were collected from observations of residents' interactions, ratings from selected functional indicators in the Minimum Data Set (MDS), and interviews with staff members. Data from on-site observations and staff interviews indicate that the added stimuli in the Edenized environment helped promote function among residents, particularly in the physical and social domains. However, no significant changes were found in most of the MDS indicators.
Pharmacological effects of naltrexone and intravenous alcohol on craving for cigarettes among light smokers: a pilot study.

Although naltrexone has been widely researched in the context of drinking and smoking behaviors, with each substance studied separately, little is known about the effects of naltrexone on craving for cigarettes during alcohol intoxication. The present study used a within-subjects double-blind placebo-controlled design to (1) examine the effects of alcohol, administered intravenously, on craving for cigarettes; (2) test the effects of naltrexone on cigarette craving during alcohol intoxication; and (3) examine the relationship between craving for alcohol and cigarettes across rising breath alcohol concentrations (BrACs). Heavy drinking light smokers completed two counterbalanced intravenous alcohol challenge sessions, one after taking naltrexone (50 mg) for 3 days and one after taking a placebo for 3 days. During each session, participants reported on their craving for alcohol and cigarettes. Analyses revealed a significant positive effect of BrAC on urge to smoke as well as a BrAC × Medication interaction. Specifically, the linear relationship between BrAC and urge to smoke was significantly weaker in the naltrexone condition, as compared to placebo. There was also a positive association between urge to drink and urge to smoke, and this relationship was moderated by BrAC. These findings demonstrate that the pharmacological effects of alcohol alone induce craving for cigarettes and that naltrexone blunts the progression of craving for cigarettes during alcohol intoxication. These results highlight the potential clinical utility of naltrexone for heavy drinkers trying to quit smoking.
Validity threats: overcoming interference with proposed interpretations of assessment data

Context Factors that interfere with the ability to interpret assessment scores or ratings in the proposed manner threaten validity. To be interpreted in a meaningful manner, all assessments in medical education require sound, scientific evidence of validity. Purpose The purpose of this essay is to discuss 2 major threats to validity: construct under-representation (CU) and construct-irrelevant variance (CIV). Examples of each type of threat for written, performance and clinical performance examinations are provided. Discussion The CU threat to validity refers to undersampling the content domain. Using too few items, cases or clinical performance observations to adequately generalise to the domain represents CU. Variables that systematically (rather than randomly) interfere with the ability to meaningfully interpret scores or ratings represent CIV. Issues such as flawed test items written at inappropriate reading levels or statistically biased questions represent CIV in written tests. For performance examinations, such as standardised patient examinations, flawed cases or cases that are too difficult for student ability contribute CIV to the assessment. For clinical performance data, systematic rater error, such as halo or central tendency error, represents CIV. The term face validity is rejected as representative of any type of legitimate validity evidence, although the fact that the appearance of the assessment may be an important characteristic other than validity is acknowledged. Conclusions There are multiple threats to validity in all types of assessment in medical education. Methods to eliminate or control validity threats are suggested.
Evaluating average and atypical response in radiation effects simulations

We examine the limits of performing single-event simulations using pre-averaged radiation events. Geant4 simulations show the necessity, for future devices, to supplement current methods with ensemble averaging of device-level responses to physically realistic radiation events. Initial Monte Carlo simulations have generated a significant number of extremal events in local energy deposition. These simulations strongly suggest that proton strikes of sufficient energy, even those that initiate purely electronic interactions, can initiate device response capable in principle of producing single event upset or microdose damage in highly scaled devices.
Making the universe safe for historians: Time travel and the laws of physics

The study of the hypothetical activities of arbitrarily advanced cultures, particularly in the area of space and time travel, as a means of investigating fundamental issues in physics is briefly discussed. Hawking's chronology protection conjecture as it applies to wormhole spacetimes is considered. The nature of time, especially regarding the viability of time travel, as it appears in several “interpretations” of quantum mechanics is investigated. A conjecture on the plausibility of theories of reality that admit relativistically invariant interactions and irreducibly stochastic processes is advanced. A transient inertial reaction effect that makes it technically feasible, fleetingly, to induce large concentrations of negative mass-energy is presented and discussed in the context of macroscopic wormhole formation. Other candidates for chronology protection are examined. It is pointed out that if the strong version of Mach's principle (the gravitational induction of mass) is correct, then wormhole formation employing negative mass-energy is impossible. But if the bare masses of elementary particles are large, finite and negative, as is suggested by a heuristic general relativistic model of elementary particles, then, using the transient effect, it is technically feasible to trigger a non-linear process that may lead to macroscopic wormhole formation. Such wormholes need not be destroyed by the Hawking protection mechanism.
Braided multi-electrode probes: mechanical compliance characteristics and recordings from spinal cords

Objective. To test a novel braided multi-electrode probe design with compliance exceeding that of a 50 µm microwire, thus reducing micromotion- and macromotion-induced tissue stress. Approach. We use up to 24 ultra-fine wires interwoven into a tubular braid to obtain a highly flexible multi-electrode probe. The tether-portion wires are simply non-braided extensions of the braid structure, allowing the microprobe to follow gross neural tissue movements. Mechanical calculation and direct measurements evaluated bending stiffness and axial compression forces in the probe and tether system. These were compared to 50 µm nichrome microwire standards. Recording tests were performed in decerebrate animals. Main results. Mechanical bending tests on braids comprising 9.6 or 12.7 µm nichrome wires showed that implants (braided portions) had 4 to 21 times better mechanical compliance than a single 50 µm wire and non-braided tethers were 6 to 96 times better. Braided microprobes yielded robust neural recordings from animals' spinal cords throughout cord motions. Significance. Microwire electrode arrays that can record and withstand tissue micro- and macromotion of spinal cord tissues are demonstrated. This technology may provide a stable chronic neural interface into spinal cords of freely moving animals, is extensible to various applications, and may reduce mechanical tissue stress.
No “Illusion of Separation”: James L. Bevel, the Civil Rights Movement, and the Vietnam War

As a student activist and member of the Southern Christian Leadership Conference, James L. Bevel played a leading role in the civil rights movement. After the passage of the landmark federal civil rights legislation of 1964–65, Bevel promoted a new set of goals for the freedom struggle including ending United States involvement in the Vietnam War. Bevel's objections to the war grew from the belief, shared by other African–American leaders, that America's Vietnam policy could not be separated from issues of race and racism. Yet Bevel's antiwar stance remained unique. Driven by the depth of his antiwar sentiment as well as by a commitment to push nonviolent social action to its fullest potential, he increasingly worked to make peace the leading goal of the civil rights movement. Bevel's effort generated new levels of cooperation between civil rights and peace activists but also highlighted some of the barriers to a strong alliance between the two movements.
Transformations to Parallel Codes for Communication-Computation Overlap

This paper presents program transformations directed toward improving communication-computation overlap in parallel programs that use MPIs collective operations. Our transformations target a wide variety of applications focusing on scientific codes with computation loops that exhibit limited dependence among iterations. We include guidance for developers for transforming an application code in order to exploit the communicationcomputation overlap available in the underlying cluster, as well as a discussion of the performance improvements achieved by our transformations. We present results from a detailed study of the effect of the problem and message size, level of communication-computation overlap, and amount of communication aggregation on runtime performance in a cluster environment based on an RDMA-enabled network. The targets of our study are two scientific codes written by domain scientists, but the applicability of our work extends far beyond the scope of these two applications.
Integrating robotics research with undergraduate education

Swarthmore College takes a two-pronged approach to undergraduate education by integrating educational goals with robotics research. First, it offers courses in artificial intelligence, computer vision and robotics. Both AI and computer vision serve as prerequisites for the robotics course. Second, it involves students in ongoing research projects as part of their undergraduate experience. To keep up with the wide-ranging, fast-moving robotics field, education must be adaptive and multidisciplinary. The authors describe two undergraduate group projects they conducted, one from 1998 at the University of North Dakota advised by Maxwell, and one from 1999 at Swarthmore advised by both authors. The impetus for these projects was the American Association for Artificial Intelligence's (AAAI's) annual robot competition. These experiences led to the development of a new robotics course at Swarthmore, which they co-taught in the spring of 2000.
Melting of iron at the physical conditions of the Earth's core

Seismological data can yield physical properties of the Earth's core, such as its size and seismic anisotropy. A well-constrained iron phase diagram, however, is essential to determine the temperatures at core boundaries and the crystal structure of the solid inner core. To date, the iron phase diagram at high pressure has been investigated experimentally through both laser-heated diamond-anvil cell and shock-compression techniques, as well as through theoretical calculations. Despite these contributions, a consensus on the melt line or the high-pressure, high-temperature phase of iron is lacking. Here we report new and re-analysed sound velocity measurements of shock-compressed iron at Earth-core conditions. We show that melting starts at 225 +/- 3 GPa (5,100 +/- 500 K) and is complete at 260 +/- 3 GPa (6,100 +/- 500 K), both on the Hugoniot curve-the locus of shock-compressed states. This new melting pressure is lower than previously reported, and we find no evidence for a previously reported solid-solid phase transition on the Hugoniot curve near 200 GPa (ref. 16).
Compressing the property mapping of polygon meshes

Many polygon meshes have properties such as shading normals, colours, texture coordinates, and/or material attributes that are associated with the vertices, faces or corners of the mesh. While current research in mesh compression has focused on connectivity and geometry coding, the compression of properties has received less attention. There are two kinds of information to compress. One specifies each individual property: the property values. The other describes how the properties are attached to the mesh: the property mapping. The authors introduce a predictive compression scheme for the property mapping that is 2 to 10 times more compact than previously reported methods.
Creating a sustainable information and communication infrastructure

Modern society's dependence on information and communication infrastructure (ICI) is so deeply entrenched that it should be treated on par with other critical lifelines of our existence, such as water and electricity. As is the case with any true lifeline, ICI must be reliable, affordable, and sustainable. Meeting these requirements (especially sustainability) is a continued critical challenge, which will be the focus of my talk. More precisely, I will provide an overview of information and communication technology trends in light of various societal and environmental mandates followed by a review of technologies, systems, and hardware/software solutions required to create a sustainable ICI.
Involvement of A1 adenosine receptors in altered vascular responses and inflammation in an allergic mouse model of asthma.

Poor lung function and respiratory disorders like asthma have a positive correlation with the development of adverse cardiovascular events. Increased adenosine levels are associated with lung infla...
Emergency airway management in critically injured patients: a survey of U.S. aero-medical transport programs.

Abstract Objective Pre-hospital airway management represents the intervention most likely to impact outcomes in critically injured patients. As such, airway management issues dominate quality improvement (QI) reviews of aero-medical programs. The purpose of this study was to evaluate current practice patterns of airway management in trauma among U.S. aero-medical service (AMS) programs. Methods The Association of Air Medical Services (AAMS) Resource Guide from 2005 to 2006 was utilized to identify the e-mail addresses of all directors of U.S. aero-medical transport programs. Program directors from 182 U.S. aero-medical programs were asked to participate in an anonymous, web-based survey of emergency airway management protocols and practices. Non-responders to the initial request were contacted a second time by e-mail. Results 89 programs responded. 98.9% have rapid sequence intubation (RSI) protocols. 90% use succinylcholine, 70% use long-acting neuromuscular blockers (NMB) within their RSI protocol. 77% have protocols for mandatory in-flight sedation but only 13% have similar protocols for maintenance paralytics. 60% administer long-acting NMB immediately after RSI, 13% after confirmation of neurological activity. Given clinical scenarios, however, 97% administer long-acting NMB to patients with scene and in-flight Glasgow Coma Scale (GCS) of 3, even for brief transport times. Conclusions The majority of AMS programs have well defined RSI and in-flight sedation protocols, while protocols for in-flight NMB are uncommon. Despite this, nearly all programs administer long-acting NMB following RSI, irrespective of GCS or flight time. Given the impact of in-flight NMB on initial assessment, early intervention, and injury severity scoring, a critical appraisal of current AMS airway management practices appears warranted.