cssi/SciSciGPT-SciSciNet huggingface dataset:
Treatment of residual anxiety symptoms with adjunctive aripiprazole in depressed patients taking selective serotonin reuptake inhibitors.

Abstract Background Depression and anxiety are common disorders and have substantially overlapping symptom complexes. Not surprisingly, treatment approaches are similar for both conditions with the selective serotonin reuptake inhibitors (SSRIs) as the initial therapy of choice. However, after first line treatments have been deployed, residual symptoms are often problematic. Augmentation strategies to address these difficulties are an area of active investigation. This study assessed aripiprazole as adjunctive therapy to SSRIs for patients with persistent anxiety symptoms complicating a depression or anxiety disorder. Methods Ten patients who had been receiving SSRIs for at least 6 weeks, but still had clinically significant anxiety symptoms, were enrolled in an open label, flexibly-dosed study of adjunctive aripiprazole. Clinical status was assessed with the Hamilton Anxiety Rating Scale (HAM-A), Montgomery Asberg Rating Scale (MADRS), and Sheehan Disability Scale (SDS). Results Eighty percent of the subjects had a greater than 50% reduction of symptoms on these outcome measures by week 2 of therapy, and continued with further decrements in symptoms throughout the course of the study. Conclusions The results of this trial provide preliminary evidence that aripiprazole may be an effective adjunctive treatment in individuals on SSRIs with residual symptoms of anxiety or depression. More rigorous double-blind studies are warranted to confirm and elucidate the potential role of aripiprazole in these conditions.
Learning Curves in Emergency Ultrasound Education

Objectives Proficiency in the use of bedside ultrasound (US) has become standard in emergency medicine residency training. While milestones have been established for this training, supporting data for minimum standard experience are lacking. The objective of this study was to characterize US learning curves to identify performance plateaus for both image acquisition and interpretation, as well as compare performance characteristics of learners to those of expert sonographers. Methods A retrospective review of an US database was conducted at a single academic institution. Each examination was scored for agreement between the learner and expert reviewer interpretation and given a score for image quality. A locally weighted scatterplot smoothing method was used to generate a model of predicted performance for each individual examination type. Performance characteristics for expert sonographers at the site were also tracked and used in addition to performance plateaus as benchmarks for learning curve analysis. Results There were 52,408 US examinations performed between May 2007 and January 2013 and included for analysis. Performance plateaus occurred at different points for different US protocols, from 18 examinations for soft tissue image quality to 90 examinations for right upper quadrant image interpretation. For the majority of examination types, a range of 50 to 75 examinations resulted in both excellent interpretation (sensitivity > 84% and specificity > 90%) and good image quality (90% the image quality benchmark of expert sonographers). Conclusions Educational performance benchmarks occur at variable points for image interpretation and image quality for different examination types. These data should be considered when developing training standards for US education as well as experience requirements for US credentialing.
Resonance Line Scattering Polarization in Optically Thin Planar Equatorial Disks.

This paper is the third in a series on the anisotropic scattering by optically thin resonance lines in extended stel- lar envelopes. Considered here is the polarization arising from resonance line scattering in equatorial disks. The shape of the polarized line profile is analytically derived under simplifying conditions of constant expansion or rotation for thin lines, with stellar occultation and finite star depolarization effects also in- cluded. The polarized profiles for the two cases are radically different. Moreover owing to the symmetries, rotation leads to profiles in both Qand U� , whereas only a Qprofile survives for an expanding disk, with U� =0 at all Doppler shifts in the line. Retaining the assumption of optical thinness, numeri- cal results are presented for more realistic disk velocity fields: truncated linear expansion and Keplerian rotation. The calcula- tions also include disk absorption of stellar continuum emission. When compared with the simplified analytic cases, many of the gross characteristics of the polarized profiles are retained.
A progesterone receptor co-activator (JDP2) mediates activity through interaction with residues in the carboxyl terminal extension of the dna binding domain

Progesterone receptor (PR) belongs to the nuclear receptor family of ligand-dependent transcription factors and mediates the major biological effects of progesterone. Transcriptional co-activators that are recruited by PR through the carboxyl-terminal ligand binding domain have been studied extensively. Much less is known about co-activators that interact with other regions of receptors. Jun dimerization protein 2 (JDP2) is a PR co-activator that enhances the transcriptional activity of the amino-terminal domain by increasing the α-helical content and stability of the intrinsically disordered amino-terminal domain. To gain insights into the mechanism of JDP2 co-activation of PR, the structural basis of JDP2-PR interaction was analyzed using NMR. The smallest regions of each protein needed for efficient protein interaction were used for NMR and included the basic region plus leucine zipper (bZIP) domain of JDP2 and the core zinc modules of the PR DNA binding domain plus the intrinsically disordered carboxyl-terminal extension (CTE) of the DNA binding domain. Chemical shift changes in PR upon titration with JDP2 revealed that most of the residues involved in binding of JDP2 reside within the CTE. The importance of the CTE for binding JDP2 was confirmed by peptide competition and mutational analyses. Point mutations within CTE sites identified by NMR and a CTE domain swapping experiment also confirmed the functional importance of JDP2 interaction with the CTE for enhancement of PR transcriptional activity. These studies provide insights into the role and functional importance of the CTE for co-activator interactions.
Role of calreticulin in store-operated Ca entry (SOCE)

Title: Role of Calreticulin in Store-operated Ca entry (SOCE) Authors: Satanay Hubrack, Awab Ibrahim, Hamid Massaeli, Nasrin Mesaeli, Khaled Machaca. Abstract: Calreticulin is a pervasive protein that is mainly found within the ER. It has been linked to many cellular functions including Ca2+ storage and signaling along with protein folding. Here we use mouse embryonic fibroblasts, both wild type (WT) and knockouts (KO) not expressing calreticulin, to investigate the effect of calreticulin on the activation of store-operated Ca entry (SOCE). SOCE is a Ca influx pathway at the cell membrane that is regulated by the Ca content in intracellular stores primarily the endoplasmic reticulum (ER). SOCE is activated through the combined action of two proteins STIM-1, an ER Ca sensor and Orai1 a plasma membrane Ca selective channel. We hypothesized that calerticulin is essential for ORAI-1 folding and chaperoning; therefore, its function is necessary for the activation of SOC. Confocal microscopy of both WT and KO cells showed the presence of Orai1 at the plasma membrane GFP-Orai-1 transfected cells. Following Store depletion using thapsigargin, endogenous puncta were seen in both WT and KO cells. Moreover, calcium imaging using ratiometric measures showed the presence of SOC after store depletion in both cell lines. From our results, we conclude that Calreticulin is not necessary for the activity or function of SOC.
Leukocyte-Poor Blood

(1986). Leukocyte-Poor Blood. CRC Critical Reviews in Clinical Laboratory Sciences: Vol. 24, No. 1, pp. 1-20.
Autologous Osteochondral Transplantation for Osteochondral Lesions of the Talus: Does Previous Bone Marrow Stimulation Negatively Affect Clinical Outcome?

Purpose To determine if functional outcomes and magnetic resonance imaging (MRI) outcomes were significantly different between patients receiving primary autologous osteochondral transplantation (AOT) and patients receiving secondary AOT surgery after failed microfracture. Methods A group of 76 patients enrolled into the Foot and Ankle Service between 2006 and 2012 was retrospectively analyzed. Patient-reported outcomes were evaluated in 76 patients using the Foot and Ankle Outcome Score (FAOS). Superficial and deep tissues at the repaired defect site, as well as the adjacent normal cartilage, were analyzed using quantitative T2 mapping MRI. Magnetic Resonance Observation of Cartilage Repair Tissue (MOCART) allowed for morphological evaluation of the repair tissue. The mean clinical follow-up time was 51 ± 23 months (range, 12 to 97 months), and the mean MRI follow-up time was 26 months (range, 24 to 36 months). Results Twenty-two patients received primary AOT and 54 received secondary AOT after failed microfracture. Patient characteristics between groups were similar with regard to age, gender, lesion size, and follow-up time. The mean postoperative FAOS was 10 points higher in the primary AOT group (83.2 ± 17.0) compared with the secondary AOT group (72.4 ± 19.4) ( P = .01). Regression analysis showed that secondary AOT patients preoperative to postoperative change in FAOS was 9 points lower than in primary AOT patients after adjustment for age, preoperative FAOS, and lesion size ( P = .045). The mean MOCART score, superficial T2 and deep T2 values, and the difference between normal and repair cartilage T2 values were not significantly different between groups. Lesion size was negatively correlated with MOCART scores (ρ = −0.2, P = .04), but positively correlated with difference in T2 values between repair and adjacent normal cartilage in the superficial layer (ρ = 0.3, P = .045). Conclusions Primary AOT shows better functional outcomes compared with secondary AOT after failed microfracture in patients with similar characteristics and lesion size. No significant differences in T2 mapping relaxation times and MOCART scores were identified. Level of Evidence Level III, case control study.
The Relation of Residual Risk and Trading Volume to Frequency of Arrival of Firm-Specific Information

The stock market has been observed to quickly incorporate new information into equity issue prices, which is consistent with the efficient market's hypothesis. However, the best available theories only explain a small portion of market volatility and volume. This study finds that firm-specific volatility reacts to firm-specific information arrival as measured by the number of newspaper stories concerning a firm appearing in The Wall Street Journal. It also finds that firm-specific information arrival and the control variables, including number of analysts and change in analyst forecast, only explain about 3% of the change in firm return variability.
New developments in prostate cancer biomarkers.

Purpose of reviewThe initial management of localized prostate cancer is increasingly complex with the identification of a growing number of prognostic subgroups. Molecular and genetic biomarkers have been proposed to help clinicians and patients navigate treatment decisions.Recent findingsThree comm
Studies on the effect of cyproheptadine on growth hormone secretion.

SummaryThe administration of cypro-heptadine to female rats transiently decreased serum GH levels. Forty-five minutes after cyproheptadine injection, in vitro GH synthesis and release was significantly decreased. Although cyproheptadine decreased PRL release in vitro, the drug had no direct in vitro inhibitory effect on GH release. Cyproheptadine did not affect the secretion of GH and PRL from transplantable tumor MtTW15, although it inhibited the in vitro release of GH from dispersed tumor cells. Cyproheptadine had no effect on either tumor size or the biological actions produced by the tumor hormones.
Curative Effect and Adverse Reaction of Oxcarbazepine on Treating Epilepsy in Children

Objective To study the curative effect and adverse reaction of Oxcarbazepine(OXC)on treating epilepsy in children.Me-thods One hundred and twenty-nine children with different types of epilepsy were orally given OXC,and the drug dose was added gradually.According to the seizure frequency,the cases were divided into 2 groups.Group A:more than 3 seizures occurred in 3 months prior to to take OXC;group B:more than 3 seizures occurred in 1 year prior to taking OXC.After 5 months and 1 year from beginning to take OXC,the original curative effect of the 2 groups was evaluated,respectively;on the other hand,the adverse reaction and the retention were studied.Results 1.Original effect:the rate of seizure-free was 45.8% and the total curative efficiency was 66.7% in group A(n=47);the rate of seizure-free was 92.3% in group B(n=13);in 60 partial epilepsy children,the rate of seizure-free was 56.7% and the total curative efficiency was 73.3%;Both rates were 62.2% and 75.6% of patients with OXC monotherapy and 40%,66.7% of patients were given OXC in combination with another antiepileptic drugs.2.Drug adverse reaction:24% of patients were found to have adverse reaction and most of the symptoms were light and most transient.3.Tolerability:patients' retention of OXC in 1 year was 72.2%,and in 2 years was 80.0%.Conclusions The antiepileptic effect of OXC is satisfactory and adverse reaction is light and mostly transient,OXC as a new antiepileptic drug is well tolerated as monotherapy and adjunctive therapy and should be used extensively.J Appl Clin Pediatr,2009,24(1):53-55
Renal hemodynamic changes after beta-blocker-diuretic combination therapy in azotemic hypertensive patients.

The effects of beta-blocker therapy with either nadolol or propranolol were compared during therapy with hydrochlorothiazide (HCTZ) 50 mg b.i.d. on glomerular filtration rate (GFR), effective renal plasma flow (ERPF), effective renal blood flow (ERBF), blood pressure, and heart rate in 22 patients with essential hypertension and mild to moderate renal insufficiency. The clearances of inulin and para-aminohippurate (PAH) were used to estimate renal hemodynamic measurements. These parameters were determined after 2 weeks of HCTZ plus placebo and at 1, 3, and 6 months after the addition of beta-blocker to HCTZ. Significant reductions in blood pressure and heart rate were seen, but no significant reduction of renal hemodynamics were seen with either beta-blocker-HCTZ combination. Since 50% of the patients in each drug group were either Black or White, hemodynamic data were also analyzed by race. One month after beta-blocker addition there was a slight reduction of GFR in both Whites (47 +/- 6 vs. 40 +/- 5 ml/min, p greater than .05) and Blacks (44 +/- 5 vs. 40 +/- 6 ml/min, p less than .05). By month 6, GFR in Whites rose to 57 +/- 9 ml/min, whereas in Blacks it fell significantly to 36 +/- 6 ml/min (p less than .01). Similarly, at month 1, ERBF declined by 12% and 13% in Whites and Blacks, respectively. However, at month 6, ERBF rose by 28% in Whites and remained 11% lower in Blacks, p less than .05. In summary, in the group as a whole neither beta-blocker significantly altered renal hemodynamics when added to HCTZ therapy.(ABSTRACT TRUNCATED AT 250 WORDS)
Normal and abnormal development of the extremities and trunk.

Normal and abnormal embryologie and postnatal development of the extremities, chest wall, breasts, and abdominal wall are described. Knowledge of development anatomy is helpful in forming a rational basis for planning and timing of surgical intervention. Clinical and potential clinical applications are described.
"Like Having a Really Bad PA": The Gulf between User Expectation and Experience of Conversational Agents

The past four years have seen the rise of conversational agents (CAs) in everyday life. Apple, Microsoft, Amazon, Google and Facebook have all embedded proprietary CAs within their software and, increasingly, conversation is becoming a key mode of human-computer interaction. Whilst we have long been familiar with the notion of computers that speak, the investigative concern within HCI has been upon multimodality rather than dialogue alone, and there is no sense of how such interfaces are used in everyday life. This paper reports the findings of interviews with 14 users of CAs in an effort to understand the current interactional factors affecting everyday use. We find user expectations dramatically out of step with the operation of the systems, particularly in terms of known machine intelligence, system capability and goals. Using Norman's 'gulfs of execution and evaluation' [30] we consider the implications of these findings for the design of future systems.
Maternal influences on growth and development of full-sibling foals.

Six pairs of full-sibling Quarter Horse foals were produced by non-surgical embryo transfer and immediate rebreeding of donor mares. Each pair of donor/recipient mares consisted of one multiparous (donor) and one nulliparous (recipient) mare of similar body type and size. Milk yield was determined within 2 d of 8, 15, 22, 29 d (early lactation); 45, 60 d (midlactation); and 90, 120 d (late lactation) postpartum by the weigh-suckle-weigh method. On the following day, milk samples were collected, and foals were weighed and measured for wither height, heart girth, metacarpal length, metatarsal length, carpus height, tarsus height, and hip height. Mean gestation length was longer (P < .05) in nulliparous mares than multiparous mares (343 vs 333 d). Daily milk production was greater (P < .05) during early lactation (12.1 vs 10.8 kg) and tended to be greater (P = .08) during midlactation (11.7 vs 10.4) in multiparous mares but was similar between groups in late lactation. Milk composition was similar between groups throughout lactation. Foals produced by multiparous mares weighed more (P < .03) throughout early lactation (70.4 vs 63.1 kg), but no differences in weights occurred between foals from multiparous and nulliparous mares through mid- and late lactation. Average daily weight gain (ADG) was similar between foal groups through early and midlactation. During late lactation, ADG tended to be greater (P = .07) in foals from nulliparous mares (1.05 vs .92 kg/d). These data suggest that nulliparous and multiparous mares of the same breed and similar body type and size produce foals with no differences in size and weight by 4 mo of age.
Importance of Creative Thinking for Paradigm Shifts that Foster Scientific Advances

There is a strong attraction among scientists, educators, and psychologists to creativity, and this attraction is supported by theories of creativity, theories of intelligence, or education because of current, rapid societal changes, global economic reformation, and technology development that require creative solutions. Because advances in science and technology are likely to affect leadership in industrial productivity, the appeal of creativity for scientists has grown among international competitors.
Biomimetic Antenna Array Using Non-Foster Network to Enhance Directional Sensitivity Over Broad Frequency Band

Biologically inspired antenna arrays that mimic the hearing mechanism of insects are called biomimetic antenna arrays (BMAAs). They are attractive for microwave applications, such as compact direction finding systems. Earlier, the BMAAs were designed for narrow frequency band phase enhancement, whereas we now propose to design them for use with a non-Foster coupling network (NFC). As the NFCs are not restricted by gain-bandwidth product, their incorporation in the design can provide wideband phase enhancement. A method for designing BMAA, using a non-Foster coupling network (NFC-BMAA), and also for obtaining system stability, is presented. Simulated and measured results of the fabricated structure are also presented and discussed.
Dangerous Domestic Spaces in The Female American

The anonymously published The Female American; or, The Adventures of Unca Eliza Winkfield (1767) belongs to a long tradition of Robinsonades, a literary subgenre that reimagines Daniel Defoe’s Robi...
Co-expression modules identified from published immune signatures reveal five distinct immune subtypes in breast cancer

There is a growing body of literature demonstrating that immune-related expression signatures predict breast cancer prognosis and chemo-/targeted-therapy responsiveness. However, it is unclear whether these signatures correlate with each other or represent distinct immune-related signals. We evaluated 57 published immune-related expression signatures in four public breast cancer datasets totaling 3295 samples. For each dataset, we used consensus clustering to group signatures together based on their co-expression pattern. Signatures that were in the same consensus cluster across all four datasets were used to define immune modules. Tumors were then classified into immune subtypes based on their module scores using consensus clustering. Survival analysis was conducted using Cox proportional hazards modeling. Consensus clustering consistently yields four distinct co-expression modules across the datasets. These modules appear to represent distinct immune components and signals, where constituent signatures relate to (1) T-cells and/or B-cells (T/B-cell), (2) interferon (IFN), (3) transforming growth factor beta (TGFB), and (4) core–serum response, dendritic cells, and/or macrophages (CSR). Subtyping of tumors based on these co-expression modules consistently yields subsets that fall into five major immune subtypes: T/B-cell/IFN High, IFN/CSR High, CSR High, TGFB High, and Immune Low. Basal and/or triple-negative breast cancer patients with CSR High tumors have significantly worse outcome relative to those within the T/B-cell/IFN High subtype. Our exploratory study identified four distinct immune co-expression modules (T/B-cell, IFN, TGFB, or CSR) from published immune signatures. Using these modules, we identified five immune subtypes with significant outcome differences in basal breast cancers.
Trading revenue, reputation and trade secrets: a stochastic control framework for business operation

In this electronic era, most businesses, especially e-businesses like IT services, business process outsourcing (BPO), online merchants etc. maintain details of daily operations and customer feedback. Relations between different business parameters can be learned from these data, which in turn can be used in decision making. In this work, we develop a stylized mathematical framework for business operations based on the knowledge gathered from past data. Our proposed framework is generic and is close to optimal in terms of long-term profitability. In optimizing long-term profit, we balance between short-term profit and long-term reputation earned based on customer satisfaction while ensuring trade secrecy. Towards this we build on stochastic control and Lyapunov techniques that have been successfully applied in communication networks.
Synthesis of biotinylated diazinon: Lessons learned for biotinylation of thiophosphate esters

Abstract Biotinylation permits recovery of a molecule from a complex mixture, with commercially available streptavidin containing products (such as streptavidin-coated beads). As part of a larger effort to evaluate reagents capable of degrading diazinon, a thiophosphate insecticide, we pursued biotinylation of this molecule. Our strategy focused on replacing a single thiophosphate ethyl ester with an ester linkage that contains biotin. Multiple approaches—using published methods—were unsuccessful and resulted in no reactivity, or degradation of starting material. Here, we report a successful strategy for the synthesis of biotinylated diazinon, which is likely applicable to alternative thiophosphate esters and other biotinylated molecules.
Forest biodiversity, relationships to structural and functional attributes, and stability in New England forests

Forest biodiversity is the foundation of many ecosystem services, and the effect of biodiversity on ecosystem functioning and processes (BEF) has been a central issue in biodiversity studies. Although many hypotheses have been developed to interpret global gradients of biodiversity, there has not been complete agreement on mechanisms controlling biodiversity patterns and distributions. Differences may be due to limited observation data and inconsistencies of spatial scales in analysis. In this study, we take advantage of USDA Forest Service forest inventory and analysis (FIA) data for exploring regional forest biodiversity and BEF in New England forests. The FIA data provide detailed information of sampled plots and trees for the region, including 6000 FIA plots and more than 33,000 individual trees. Biodiversity models were used to analyze the data. Tree species diversity increases from the north to the south at a rate about 2–3 species per latitudinal degree. Tree species diversity is better predicted by tree height than forest age or biomass. Very different distribution patterns of two common maple species, sugar maple (Acer saccharum) and red maple (Acer rubrum), highlight the vulnerability of sugar maple and its potential replacement by red maple on New England landscapes. Red maple generally already outperforms sugar maple, and will likely and continuously benefit from a changing climate in New England. We conclude that forest structure (height) and resources (biomass) are more likely foundational characteristics supporting biodiversity rather than biodiversity determining forest productivity and/or biomass. The potential replacement of red maple for sugar maple in the New England areas could affect biodiversity and stability of forest ecosystem functioning because sugar maple plays important ecological roles distinct from red maple that are beneficial to other tree species in northern hardwood forests. Such a change may not affect forest resilience in terms of forest productivity and biomass as these are similar in red maple and sugar maple, however, it would almost certainly alter forest structure across the landscape.
Assessment of Direct Use of Geothermal Hot Water for Snow-Melting Pavements in Western North Dakota Using Finite Element Method

Many advanced snow-melting methods for heating pavements have been studied, and the deep direct use (DDU) of geothermal hot water is considered to be a clean and economical resource for developing snow-melting pavement systems for cold regions. In western North Dakota, the cold climate hinders many economic activities due to the uncertainties associated with transportation. The presence of snow on roads and airport runways is a major problem, and thus, improving snow removal methods and transportation infrastructure in winter is vital to the economy and road safety. The use of geothermal hot water for snow-melting purposes provides a solution to these problems and has many advantages. In western North Dakota, the temperatures of geothermal hot water range between 30 °C to 130 °C, and water at these temperatures is available between 700 m and 3,500 m deep in several aquifers. These geothermal aquifers have been identified and are found to be able to supply good quality and abundant hot water. This paper focuses on two populated locations above these easily accessible aquifers. The paper considers the feasibility of a snow-melting system that uses DDU geothermal hot water based on heat transfer and the available heat supply. The heat requirements for melting snow are computed based on the climatic conditions in the studied areas using the Chapman and Katunich equations. Finite element analysis using COMSOL is employed to model the pavement heating processes, from pipes embedded in a concrete panel to the pavement surface according to the computed heat requirements. The heat supply also takes into account the cascading use of geothermal hot water for different temperatures, pipe properties, mass flow rates, reasonable water pressures, snow-melting efficiency, and the properties of concrete pavement panels. The feasibility of the proposed snow-melting pavement panels is assessed and an optimized design is recommended.
The Use of Simulation in the Training for Spinal Cord Stimulation for Treatment of Chronic Pain

Spinal cord stimulation (SCS) requires training to maximize its therapeutic effect and minimize surgical risks to the patients. Learning through the observation and operation in the operating room (OR) has been the majority of surgical training, which has faced many issues, including patient safety, work hour limitations, and cost of OR time. SCS has been developed as an established treatment for chronic neuropathic pain. Proper electrode insertion is one of the most important technical parts of SCS approach, which is related to a good outcome of patients. However, high levels of functioning in these patients with chronic pain have prevented hands-on training for surgeons. Simulation-based surgical training provides an opportunity to teach surgeons and allow them to practice surgical procedures outside the OR in high-quality and time-effective manner. This chapter focuses on the simulation of SCS procedure for treatment of chronic neuropathic pain.
Generating Configuration Files: The Director's Cut

The generation of system configuration files and other documents directly from a database has proven to be a very powerful technique. However, there were some limitations to this approach. With the introduction of Oracle 8i, and more specifically, the addition of support for XML, we have been able to eliminate many of these limitations and take the file generation and maintenance to a new level.
EBV Related B Cell Lymphoproliferative Disease after T Depleted Mismatched Bone Marrow Transplantation

Bone marrow transplantation (BMT) can be life saving for patients with otherwise fatal malignant and non-malignant diseases. Since the majority of people lack an HLA identical sibling much effort has gone into the use of partially mismatched donors. The major obstacles in mismatched BMT have been graft rejection and severe graft vs. host disease. At the University of Minnesota we have experienced an additional complication of mismatched BMT; B cell lymphproliferative disease (BLPD) associated with EBV. Five of twenty one (24$) recipients of T depleted mismatched BMT developed fatal overwhelming lymphoproliferative processes in comparison to the very low incidence in matched T depleted (0/25) or matched non-depleted (1/>500) setting. It is clear that this subgroup of BMT recipients is at an alarmingly increased risk of developing this complication.
Elastic Properties Related to Depth of Burial, Strontium Content and Age, and Diagenetic Stage in Pelagic Carbonate Sediments

Laboratory measurements of density (p), compressional (Vp) and shear (Vs) velocities, and velocity anisotropies (Ap) and (As) in a pelagic ooze-chalk-limestone sequence from DSDP Site 289 are viewed in light of its present depth of burial, sediment age and diagenetic stage.
Doing their own math: computer support of discursive approaches to real math problems

Traditionally, there has been no obvious role for the computer in an elementarylevel classroom oriented toward "talking about math" as a way of deepening children's understanding of mathematical problem situations. We suggest that an appropriate computer learning environment can serve as a useful tool to both complement and be enhanced by discursive approaches to mathematics. In this paper we describe software, some of which is currently being tested in classrooms, which allows students to create and share word problems motivated by classroom discussion of an arithmetically relevant situation, and to dynamically explore links between linguistic and other symbolic representations of their problems and those of other children. In conjunction with the discursive approach, these facilities support pedagogical methods such as the integration of writing, science and mathematics; roles for students as knowledge contributors rather than as passive recipients; and a motivated use of the computer for understanding mathematical problem relationships.
Safety and long-term efficacy of AAV1.SERCA2a using nebulizer delivery in a pig model of pulmonary hypertension.

Nebulization delivery of adeno-associated virus serotype 1 encoding sarcoplasmic reticulum Ca2+-ATPase2a (AAV1.SERCA2a) gene was examined in a Yukatan miniature swine model of chronic pulmonary hyp...
Ligand-mediated dephosphorylation signaling for MAP kinase.

Abstract Extracellular signal-regulated kinase (ERK), also known as classical mitogen-activated protein kinase, plays critical roles in cell regulation. ERK is activated through phosphorylation by a cascade of protein kinases including MEK. Various ligands activate the MEK/ERK pathway through receptor-dependent cell signaling. In cultured cells, many ligands such as growth factors, hormones, cytokines and vasoactive peptides elicit transient activation of MEK/ERK, often peaking at ~10 min after the cell treatment. Here, we describe a novel biological event, in which ligand-mediated cell signaling results in the dephosphorylation of MEK/ERK. Neuromedin N and neurotensin, peptides derived from the same precursor polypeptide, elicit cell signaling through the neurotensin receptors. In cultured human pulmonary artery smooth muscle cells (PASMCs), but not in human pulmonary artery endothelial cells (PAECs), we found that both neuromedin N and neurotensin promoted the dephosphorylation of ERK and MEK. Human PASMCs were found to express neurotensin receptor (NTR)-1, −2 and −3, while human PAECs only express NTR3. Neuromedin N-mediated dephosphorylation was suppressed by small chemical inhibitors of protein phosphatase 1/2A and peptidyl-prolyl isomerase. Transmission electron microscopy showed the formation of endocytic vesicles in response to neuromedin N treatment, and dephosphorylation did not occur when sorting nexin 9, a critical regulator of the endocytic vesicle formation, was knocked down. We conclude that neuromedin N and neurotensin elicit a unique dephosphorylation signaling in the MEK/ERK pathway that is regulated by endocytosis. Considering the pathophysiological importance of the MEK/ERK pathway, this discovery of the dephosphorylation mechanism should advance the field of cell signaling.
Anilinium Salts in Polymer Networks for Materials with Mechanical Stability and Mild Thermally Induced Dynamic Properties

Dynamic nucleophilic exchange of quaternary anilinium salts has been incorporated into rehealable and malleable polymeric materials that can be activated under mild (60 °C) thermal stimulus. The mechanism of dynamic exchange between quaternary anilinium salt and free aniline was assessed in small-molecule model experiments. The dynamic exchange was found to be dissociative in nature, due to the indirect SN2 mechanism, where initially the bromide anion attacks the anilinium salt to generate an alkyl bromide which undergoes subsequent attack by a free aniline group. A quaternary anilinium-based cross-linker was synthesized to act as dynamic linkages in the polymer network. Cross-linked polymeric materials showed thermoresponsive rehealing and malleability properties at 60 °C along with being resistant to irreversible creep under ambient conditions. The use of anilinium salts enables dynamic exchange to occur with significantly milder thermal stimulus than other comparable materials, while maintaining mechan...
Small-intestinal enteroliths--unusual cause of small-intestinal obstruction: report of three cases.

Purpose The aim of this study was to report on a rare cause of small-intestinal obstruction caused by small-intestinal enteroliths. METHODS: We present three different cases of enterolith formation in the small intestine. One occurred after nontropical sprue, one patient had multiple jejunal diverticula, and another patient had enterolith formation in a blind loop after a small-bowel side-to-side anastomosis. RESULTS: After initial conservative therapeutic approach all patients underwent surgery. In two patients the enteroliths were removed by ileotomy or jejunostomy. In the third patient the bowel anastomosis had to be revised after removal of the enterolith. CONCLUSION: Small-intestinal enteroliths may cause small-bowel obstruction. The first therapeutic approach is nonsurgical; however, if obstruction proceeds, surgical removal with or without revision of underlying pathology is necessary. We discuss the causes and therapeutic management of enteroliths and give a review of related literature.
Lagrangian carotid strain imaging indices normalized to blood pressure for vulnerable plaque

Objective Ultrasound Lagrangian carotid strain imaging (LCSI) utilizes physiological deformation caused by arterial pressure variations to generate strain tensor maps of the vessel walls and plaques. LCSI has been criticized for the lack of normalization of magnitude-based strain indices to physiological stimuli, namely blood pressure. We evaluated the impact of normalization of magnitude-based strain indices to blood pressure measured immediately after the acquisition of radiofrequency (RF) data loops for LCSI. Materials and methods A complete clinical ultrasound examination along with RF data loops for LCSI was performed on 50 patients (30 males and 20 females) who presented with >60% carotid stenosis and were scheduled for carotid endarterectomy. Cognition was assessed using the 60-minute neuropsychological test protocol. Results For axial strains correlation of maximum accumulated strain indices (MASI), cognition scores were -0.46 for non-normalized and -0.45, -0.49, -0.37, and -0.48 for systolic, diastolic, pulse pressure, and mean arterial pressure normalized data, respectively. The corresponding area under the curve (AUC) values for classifiers designed using maximum likelihood estimation of a binormal distribution with a median-split of the executive function cognition scores were 0.73, 0.70, 0.71, 0.70, and 0.71, respectively. Conclusions No significant differences in the AUC estimates were obtained between normalized and non-normalized magnitude-based strain indices.
“Art with a Purpose”: Across Transpacific Generations

Mitsu Yashima (1908–1988) was a political dissident and artist in two countries: In prewar Japan, she became a proletarian rights activist; during World War II, she continued to oppose Japanese mil...
A low temperature unitized regenerative fuel cell realizing 60% round trip efficiency and 10 000 cycles of durability for energy storage applications

Unitized regenerative fuel cells (URFC) convert electrical energy to and from chemical bonds in hydrogen. URFCs have the potential to provide economical means for efficient long-term, seasonal, energy storage and on-demand conversion back to electrical energy. We first optimize the catalyst layer for discrete electrolyzer and fuel cell and then configure the URFC. The goal is to identify a cost competitive configuration for URFCs, and demonstrate it in terms of upper limit of round trip efficiencies (RTEs). Two possible configurations of URFCs are compared via experiments and techno-economic analysis (TEA), which emphasize the advantages of the unconventional constant-electrode (CE) URFC over the traditional constant-gas (CG) configuration. We also study the stability via accelerated stress tests (ASTs) and demonstrate steady state operation in a daily cycle for day to night energy shifting. From the investigations, the optimum composition of the URFC anode catalyst layer is 90 at% Ir-black balanced by Pt-black for both CE and CG configurations. At 80 °C and 1 A cm−2, the optimized CE URFC achieves 57% and 60% RTE with air and O2 as the reductant gases, respectively. We then evaluated the differences in durability using an AST over 10k charge–discharge cycles; the results reveal that the wider potential window at the anode in CE (0.05–1.55 V) has minimal effect on catalyst layer stability compared to CG (0.55–1.55 V). Furthermore, there was no degradation up to the range of 2k–5k cycles; beyond that the fuel cell (discharge) performance degraded while the electrolyzer (charge) performance was still stable. The observations here indicate substantial potential to employ URFCs as efficient and cost-effective bidirectional energy-conversion devices within energy storage and utilization systems after appropriate technological and operational optimizations.
The Scale-Up of Linked Multilevel Interventions: A Case Study

In this chapter, we describe the scale-up and impact of a linked multilevel intervention in a public child welfare system. Linked multilevel interventions are interventions with multiple components that target one or more levels within the systems. In health care, multilevel interventions are gaining traction, but there are few references to multilevel interventions in the child welfare despite obvious parallels. Families with children in the child welfare system face challenges across multiple life domains, and the systems designed to serve those families are administratively and financially interdependent. Single prong interventions that address one level of the service system while ignoring the interdependencies may be less effective. In this chapter, we describe one attempt to align the interdependencies in ways that improve the chances an intervention will have its intended effect.
Impact force and moment problems on random mass density fields with fractal and Hurst effects.

This paper reports the application of cellular automata to study the dynamic responses of Lamb-type problems for a tangential point load and a concentrated moment applied on the free surface of a h...
Infection situation of human papillomaviruses in village women in Xinmi City

Objective To investigate the prevalence of high-risk HPV in village women in Xinmi City and to discuss risk factors related with HPVs infection.Methods It was an population based cross-sectional study on cervical cancer in village women in Xinmi.Women aged 20-54 with the history of sex were enrolled in this paper.Two ways(self-sampling and direct-sampling)were used to collect women's vaginal discharge.13 high-risk HPVs were tested with HC2 for all of the specimens.Then women with abnormal results did colposeopy and biopsy.We used biopsy results as the golden standard.Results There were 881 women enrolled in this paper and 881 self-sampling and 880 direct-sampling specimens were colleted.Self-sampling and direct-sampling HPVs prevalence rates were 13.05%and 12.27%respectively.Prevalence rates of different age groups were 10.57%(20-),9.60%(25-),12.00%(30-),9.52%(35-),17.60%(40-),13.74%(45-)and 12.80%(50-).HPV prevalence rates were increased with progression of cervical disease(χ2=200.69,P=0.00).And HPV prevalence rates were higher in women with more advanced educated level(χ2=11.05,P=0.01).HPV infection rate in women whose husbands have more than one sexual partner was 18.02%and those husbands have only one sexual partner was 10.88%(χ2=6.37,P=0.01).Conclusion The infection rate of high-risk HPVs in this area is high.HPV infection has no relationship with age.Sexual activity is the main risk factor of cervical cancer. Key words: Cervix neoplasms; Human papillomavirus; Fluoroimmunoassay; Data interpretation,statistical
Materials design for bone-tissue engineering

Successful materials design for bone-tissue engineering requires an understanding of the composition and structure of native bone tissue, as well as appropriate selection of biomimetic natural or tunable synthetic materials (biomaterials), such as polymers, bioceramics, metals and composites. Scalable fabrication technologies that enable control over construct architecture at multiple length scales, including three-dimensional printing and electric-field-assisted techniques, can then be employed to process these biomaterials into suitable forms for bone-tissue engineering. In this Review, we provide an overview of materials-design considerations for bone-tissue-engineering applications in both disease modelling and treatment of injuries and disease in humans. We outline the materials-design pathway from implementation strategy through selection of materials and fabrication methods to evaluation. Finally, we discuss unmet needs and current challenges in the development of ideal materials for bone-tissue regeneration and highlight emerging strategies in the field. Design of bone-tissue-engineering materials involves consideration of multiple, often conflicting, requirements. This Review discusses these considerations and highlights scalable technologies that can fabricate natural and synthetic biomaterials (polymers, bioceramics, metals and composites) into forms suitable for bone-tissue-engineering applications in human therapies and disease models.
A Patient-Specific Computational Framework for the Argus II Implant.

Goal: Retinal prosthesis performance is limited by the variability of elicited phosphenes. The stimulating electrode's position with respect to retinal ganglion cells (RGCs) affects both perceptual threshold and phosphene shape. We created a modeling framework incorporating patient-specific anatomy and electrode location to investigate RGC activation and predict inter-electrode differences for one Argus II user. Methods: We used ocular imaging to build a three-dimensional finite element model characterizing retinal morphology and implant placement. To predict the neural response to stimulation, we coupled electric fields with multi-compartment cable models of RGCs. We evaluated our model predictions by comparing them to patient-reported perceptual threshold measurements. Results: Our model was validated by the ability to replicate clinical impedance and threshold values, along with known neurophysiological trends. Inter-electrode threshold differences in silico correlated with in vivo results. Conclusions: We developed a patient-specific retinal stimulation framework to quantitatively predict RGC activation and better explain phosphene variations.
Age of Sexual Debut among Young Gay-identified Sexual Minority Men: The P18 Cohort Study.

Age of sexual debut is a critical health indicator for young sexual minority men (YSMM), associated with an increased likelihood of HIV acquisition, use of alcohol, tobacco, and other substances, a...
Activity Recommendations After Total Hip and Total Knee Arthroplasty.

» A formal unsupervised activity program should be recommended to all patients recovering from total knee arthroplasty (TKA) and total hip arthroplasty (THA). » In a subset of all patients undergoing TKA or THA, studies have found that an unsupervised activity program may be as efficacious as supervised physical therapy (PT) after surgery. Certain patients with inadequate independent function may continue to benefit from supervised PT. » For TKA, supervised telerehabilitation has also been proven to be an effective modality, with studies suggesting equivalent efficacy compared with supervised in-person PT. » Following TKA, there is no benefit to the use of continuous passive motion or cryotherapy devices, but there are promising benefits from the use of pedaling exercises, weight training, and balance and/or sensorimotor training as adjuncts to a multidisciplinary program after TKA. » No standardized postoperative limitations exist following TKA, and the return to preoperative activities should be dictated by an individual's competency and should consist of methods to minimize high impact stress on the joint. » Despite traditional postoperative protocols recommending range-of-motion restrictions after THA, it is reasonable to recommend that hip precautions may not be needed routinely following elective primary THA.