cssi/SciSciGPT-SciSciNet huggingface dataset:
Individual differences in imaginal and verbal information processing abilities

noun-pairs. However, there are exceptions to this general finding in that some individuals can use imagery effectively with abstract pairs, which would suggest that imagery processes in general might be more available for these people (Paivio, 197lb). The distinction between spatially parallel and sequential processing of information in imaginal and verbal symbolic systems implies that imagery should be advantageous in memory tasks that involve spatial organization of informational units or retrieval of spatial information from memory, whereas verbal pro~esses should be superior in tasks that require the sequential order of items to be remembered. This functional distinction may provide a partial explanation for the apparent superiority of imagery with concrete items. With integrated images, information
Low Dose Azacitidine Maintenance Therapy Following Allogeneic Stem Cell Transplantation for MDS/AML Does Not Interact with Tacrolimus Dosing or Serum Levels

Abstract 4209 Background: Recurrence of disease remains a significant cause of morbidity and mortality in patients who undergo allogeneic SCT for AML and MDS. Low-dose azacitidine is currently under investigation in the post-transplant setting with the goal of prolonging disease-free survival and decreasing relapse rates. It is unclear if there is potential pharmacologic interaction between azacitidine and dose-adjusted tacrolimus used to prevent post-transplant graft-versus-host disease (GVHD), a clinically relevant question since any resultant tacrolimus under- or over-dosing may lead to increased risk of GVHD or drug toxicity, respectively. We hypothesized that azacitidine does not significantly interact with tacrolimus levels and performed a retrospective analysis to test this hypothesis. Patients and Methods: We reviewed tacrolimus daily doses and serum drug levels of 62 AML and MDS patients who received azacitidine maintenance therapy (n=30) or no maintenance therapy (n=32) following allogeneic stem cell transplantation at MD Anderson Cancer Center between 2008–2012. Patient characteristics are summarized in the Table. Patients in the maintenance cohort received subcutaneous azacitidine at 32 mg/m2 on days 1–5 repeated every 28 days starting at a median time of post-transplant day +65 (range 43–100). Tacrolimus doses and serum levels were averaged for 28 days for each patient before and after initiation of azacitidine maintenance and at day +66 in the non-maintenance cohort. Differences between the two cohorts in their mean change of tacrolimus doses and serum drug levels were assessed using a Student9s t-test. Results: Mean (SD) oral tacrolimus doses pre- and post-maintenance therapy were 2.61 (2.13) mg daily and 2.44 (2.15) mg daily in the azacitidine group and 2.54 (1.86) mg and 2.23 (1.39) mg daily in the non-azacitidine cohort. This resulted in a mean change in tacrolimus dosing of -0.17 (1.16) mg daily in the azacitidine patients and -0.31 (1.10) mg daily in the non-maintenance group (p=0.62). Mean (SD) serum tacrolimus levels pre- and post-maintenance therapy were 8.07 (1.16) ng/mL and 7.58 (2.32) ng/mL in the azacitidine group and 8.23 (1.49) ng/mL and 7.10 (1.69) ng/mL in patients on no maintenance therapy. This resulted in a mean change in serum tacrolimus levels of -0.49 (2.75) ng/mL in the azacitidine cohort and -1.13 (2.04) ng/mL in the non-maintenance group (p=0.30). Conclusion: Maintenance azacitidine therapy following allo-SCT for AML and MDS does not appear to affect concurrent tacrolimus dosing or serum drug levels. Disclosures: Off Label Use: azacitidine: off-label use as maintenance therapy following allogeneic stem cell transplant for MDS/AML. Champlin:Otsuka: Research Funding. De Lima:Celgene: Research Funding.
The Association Between IGF-1 Levels and the Histologic Severity of Nonalcoholic Fatty Liver Disease

The Association Between IGF-1 Levels and the Histologic Severity of Nonalcoholic Fatty Liver Disease
The importance of testing Smart Grid IEDs against security vulnerabilities

As the Smart Grid becomes highly interconnected, the power protection, control, and monitoring functions of the grid are increasingly relying on the communications infrastructure, which has seen rapid growth. At the same time concerns regarding cyber threats have attracted significant attention towards the security of power systems. A properly designed security attack against the power grid can cause catastrophic damages to equipment and create large scale power outages. The smart grid consists of critical IEDs, which are considered high priority targets for malicious security attacks.
Observations on Turbinella Scolymoides Dall, with Description of a New Species Turnbinella

Turbinella scolymoides Dall (Mollusca, Gastropoda), described from the Pliocene of Florida, has been discovered in the Recent fauna of Yucatan. It is suggested that the common Recent species T. angulata (Solander in Lightfoot) developed independently in the Miocene of the southern Caribbean and subsequently invaded the indigenous northern T. scolymoides population, virtually replacing it except in the asylum of the Yucatan area. The lower age limit of T. scolymoides is tentatively fixed at the Miocene-Pliocene boundary, possibly due to a warming trend in water temperatures at the end of the Miocene.
Automated Technical Control (ATEC)

ABSTRACT Automated Technical Control (ATEC) is sponsored by the Rome Air Development Center (USAF) with participation and guidance from Defense Communications Agency, U.S. Army, and U.S. Navy. Technical Control is the function within the military communications organizations that provides quality control of communications provided to users of the service. Activities performed by Technical Control include circuit quality assessment, alternate routing, new circuit engineering and implementation, recordkeeping, and status reporting. Upgrading will be accomplished by automating many of the functions within Technical Control, providing the operator with capability presently lacking, and relieving him of many time-consuming recordkeeping tasks, thus freeing him for more productive tasks that require his deductive or analytical abilities. Automated Technical Control (ATEC) is entering the development stage at the present time, having been the subject of extensive study and analysis for the past several years. Automation is achieved through judicious use of a family of process control computers, special automated test equipment, automated switching equipment, and operator consoles. The consoles are used interactively by the operators to accomplish performance monitoring, fault isolation, circuit rerouting, equipment substitution, recordkeeping, and reporting. Primary emphasis in the system design has been to require the computer to do things it does best and allow the man to do things he does best.
Fabrication and nonlinear optical investigations of SiO2@Ag core-shell nanoparticles

Abstract SiO 2 @Ag core-shell nanoparticles were successfully prepared by a facile and simplified synthesis strategy. Initially, the SiO 2 nanospheres were synthesized without functionalization using any silanols. Subsequently, by higher loading of Ag particles onto SiO 2 nanospheres, positively charged Ag(NH 3 ) 2 + ions were treated with negatively charged SiO 2 surface followed by a reduction reaction to obtain SiO 2 @Ag core-shell nanoparticles. The resultant Ag nanoparticles exhibit a strong absorption band at 410 nm over the amorphous SiO 2 nanospheres. FTIR spectroscopy evidenced the presence of amine and nitro compounds in the products and revealed that the SiO 2 surface is mostly filled with Ag NPs. The crystal structure and chemical composition were examined by Powder XRD analysis and X-ray photoelectron spectroscopy respectively. The FESEM micrographs visualized the successful formation of SiO 2 @Ag core-shell NPs and EDS analysis confirmed the higher loading of Ag NPs. The optical nonlinearity was examined by z-scan measurement at the excitation wavelength of 632.8 nm using a continuous wave red He-Ne laser.
Composition of phytodetrital food resources affects reproductive success in the deposit-feeding sea cucumber, Parastichopus californicus (Stimpson 1857)

Abstract Phytoplankton are important sources of dietary fatty acids (FAs) for higher trophic levels, yet FA composition varies among phytoplankton taxa, and under different growth conditions. Changes in the environment that lead to shifts in the composition of phytoplankton communities may thus alter FA supply in marine food chains. Reproductive processes in free-spawning marine invertebrates, which provision eggs with lipid to fuel early embryonic development, are particularly impacted by FA composition of the diet. In order to explore the effects of taxonomic changes in the source of phytodetrital food resources on invertebrate consumers, we conducted captive feeding experiments to examine differences in reproductive fitness of deposit-feeding sea cucumbers ( Parastichopus californicus ) fed two different algal diets. Body- and egg-condition variables were measured in females that were fed detritus of either the green alga Tetraselmis sp. or the diatom Thalassiosira sp., which differ in nutritional and FA composition. Subsequent timing of development and survival were recorded for pre- and post-feeding larval stages. FA analyses were conducted on feeds, spawned gonads, and eggs to identify specific FAs allocated to reproduction. Females that were fed Tetraselmis sp. had higher fecundity, but showed reduced larval survival relative to females that were fed the diatom Thalassiosira sp. Similar rates of larval development were recorded in both treatments. Significant differences were observed in the abundance of 20:5ɷ3 (EPA), 20:4ɷ4 (ARA), 22:3ɷ6 (DHA), 12:0, 16:0, and 18:0 FAs in eggs and gonads from females fed the two diets. Diet-related variation in fecundity and egg quality could directly affect recruitment success in P. californicus , and suggests that reproductive strategies may be altered under different environmental conditions. If feeding conditions are favorable to planktotrophic larvae, then producing a larger number of eggs with lower energy density (such as under Tetraselmis -fed treatments) may be acceptable, whereas different conditions may favor maternal investment in a smaller number of better-provisioned eggs (such as in Thalassiosira- fed treatments).
Killed Brownian Motion

Let X t be the d-dimensional Brownian motion and D a domain in ℝ d (d≥ 1). Adjoin an extra point ∂ to D and set $$ X_t^D = \left\{ {\begin{array}{*{20}c} {X_t on (t < \tau _D )} \\ {\partial on (t \geqslant \tau _D ).} \\ \end{array} } \right. $$
Dark Matter + Higgs($$\rightarrow b\bar{b}$$): Results

This chapter presents the results of this search and the statistical interpretations. For a description of the Z ′ -2HDM signal model that is used to benchmark this search, see Chap. 7 The signal region selections are defined in Chap. 9 The various background processes are described in Chap. 10
Hypercalcemia associated with cosmetic injections: a systematic review

Introduction Cosmetic injections with silicone and polymethylmethacrylate are not FDA approved for augmentation of body parts such as breast, buttock or legs, but they have been widely used for decades. Cosmetic injections can cause foreign body granulomas and occasionally severe and life-threatening hypercalcemia. We aimed to systematically analyze the published literature on cosmetic injection-associated hypercalcemia. Methods We searched relevant articles on hypercalcemia associated with various cosmetic injections and extracted relevant data on demographics, cosmetic injections used, severity of hypercalcemia, management and outcomes. Results We identified 23 eligible patients from 20 articles. Mean age was 49.83 ± 14.70 years with a female preponderance (78.26% including transgender females). Silicone was most commonly used, followed by polymethylmethacrylate and paraffin oil (43.48, 30.43, and 8.70% respectively). The buttock was the most common site followed by the breast (69.57% and 39.13% respectively). Hypercalcemia developed at mean duration of 7.96 ± 7.19 years from the initial procedure. Mean ionized calcium at presentation was 2.19 ± 0.61 mmol/L and mean corrected calcium at presentation was 3.43 ± 0.31 mmol/L. 1,25-Dihydroxyvitamin D (1,25(OH)2D or calcitriol) was elevated while 25-hydroxyvitamin D (25(OH)D) and PTH were low in majority of cases. Hypercalcemia was managed conservatively with hydration, corticosteroids and bisphosphonates in majority of cases. Surgery was attempted in 2 cases but was unsuccessful. Renal failure was the most common complication (82.35% cases) and 2 patients died. Conclusion Hypercalcemia from cosmetic injections can be severe and life threatening and can present years after the initial procedure. Cosmetic injection-associated granuloma should be considered a cause of hypercalcemia, especially in middle-aged females presenting with non-PTH-mediated, non-malignant hypercalcemia, which is often associated with elevated calcitriol; however, it should be noted that calcitriol level may be normal as well.
Applications of Augmented Reality in Informal Science Learning Sites: a Review

The importance of increasing interest in the STEM disciplines has been noted in a number of recent national reports. While many previous studies have focused on such efforts inside of the formal classroom, comparatively few have looked closely at informal learning environments. We investigate the innovative use of technology in informal learning by reviewing research on the incorporation of augmented reality (AR) at exhibit-based informal science education (ISE) settings in the literature. We report on the common STEM-focused topics that are covered by current AR applications for ISE learning, as well as the different devices used to support these applications. Additionally, we report on the prevalence of positive learning outcomes and engagement factors commonly associated with the use AR applications in informal environments. This review aims to foster continued development and implementation of AR technology in exhibit-based ISE settings by informing the community of recent findings and promoting additional rigorous research for the future.
Clocked cell cycle clocks: implications toward chronopharmacology and aging.

Cell developmental and division cycles, comprising relatively discrete morphological and biochemical events that may be ordered sequentially or in a branching network, constitute “clocks” themselves in a general sense. Yet abundant evidence exists in both unicellular protistan and algal populations and in cultured mammalian cells that the cell division cycle (and perhaps other related cyclic events) may itself be modulated (or “clocked”) by a circadian oscillatory mechanism (an endogenous, self-sustaining oscillation) that at one level is conceptually and operationally distinct from the cell division cycle itself, but nevertheless, must ultimately be associated with, and generated by, basic cell cycle processes since the oscillatory mechanism(s) is itself replicated during each cell division cycle. A summary of the empirical evidence for these assertions is given in the first section of this paper.
'The Free Use of Our Faculties': Jefferson, Cyberspace, and the Language of Social Life

The Internet is a language, a language that allows individuals to write texts (in a wide variety of other languages) and to communicate the meaning of those texts to others. Cyberspace is, in that very real sense, an entirely imagined world - a consensual hallucination, as one particularly perceptive observer nicely put it, a collection of stories. How is law to be made and enforced here? Life must be lived forward, but it can only be understood backwards. My premise is that looking backward to try to understand how others looked forward will help us to make sense of the choices we face in cyberspace. Looking backward, we find Thomas Jefferson, who spent a lot of time looking forward, and who had a particular vision when he did so. If we're thinking about how, going forward, law should be made in this new language-place, this-place-that-is-noplace, we could do worse than to try to understand what Jefferson thought about how, going forward, law should be made in his new world, a new world that looked as bizarre to him and his contemporaries as cyberspace does to us. But if we're thinking about how, going forward, law should be made in this new language-place, this-place-that-is-noplace, we could do worse than to try to understand what Jefferson thought about how, going forward, law should be made in his new world, a new world that looked as bizarre to him and his contemporaries as cyberspace does to us. Recapturing Jefferson's vision requires recapturing the shape of the intellectual battles in which he was engaged. Jefferson had a great deal to say about language and its control. He was engaged in one of the major intellectual battles of the 18th century: who controls English, or French, or the other languages of the world? How can they be controlled? What happens if they're not? Jefferson (and others, of course) prevailed in that battle, creating a kind of self-evident truth about the nature of freedom and the nature of language. But apparently we have to fight the battle all over again when confronting the languages of cyberspace. We again hear that they are too important, too indispensable as vehicles for commerce and of learning, to leave their growth and future development entirely to the uncoordinated chaos of the mob, away from the experts and outside the State's apparatus control. If it seems self-evidently wrong in retrospect, why does it not seem self-evidently wrong in prospect?
Comment on Acarus putrescentiae Schrank, 1781 (currently Tyrophagus putrescentiae; Acariformes, acaridae): proposed conservation of usage by designation of a replacement neotype

Abstract. The purpose of this application, under Article 75.6 of the Code, is to conserve the current usage of the name Tyrophagus putrescentiae (Schrank, 1781) for a ubiquitous, medically and economically important species of acariform mite (family acaridae) by setting aside the existing name-bearing type and designating a replacement neotype. Cultures of this mite species are maintained in many research institutions or companies and are commercially traded as a source of mite allergens, food for phytoseiid mites used in biological control, and for various molecular biology applications. A recent taxonomic treatment indicated that the taxonomic concept of T. putrescentiae involved two closely related species, one common and one rare, and the neotype designated by Robertson (1959) for T. putrescentiae corresponds to the rare species; the common species was renamed as Tyrophagus communis Fan & Zhang, 2007. We demonstrated that the prevailing usage of the name T. putrescentiae comprises almost exclusively t...
A 400-MHz, 10-bit Charge Domain CMOS D/A Converter for Low-Spurious Frequency Synthesis

This paper describes a 10b DAC implemented in 0.6 μm CMOS, which converts at rates up to 400 MS/s. The DAC and associated circuits occupy 1.2 mm2. DNL is less than 0.25 LSB and INL less than 0.35 LSB. The DAC consumes 95 mW total from 3.3V, of which 25 mW is in the buffer op amp. This DAC’s unique feature is its relatively flat SFDR over the full Nyquist range of synthesized frequencies. At conversion rates beyond 100 MHz, op amp dynamics limit peak SFDR.
The Nature of Repulsive States and the Role of Nuclear Dynamics in Desorption Induced by Electronic Transitions

Electrons and photons cause desorption by exciting transitions to electronic states that are repulsive, i.e. by breaking bonds. Thus, understanding desorption means understanding the behavior of excited electronic states at surfaces and the coupling of repulsive potential energy into atomic motion. In the first attempt to provide a microscopic description of the ESD/PSD process, Menzel, Gomer[l] and Redhead[2] (MGR) discussed the role of Franck-Condon transitions to repulsive excited states and the role of the substrate in the quenching of these excitations. The MGR model has provided the conceptual framework to discuss DIET processes in the valence region of the spectrum. Unfortunately, however, there has been little progress towards identifying the specific nature of these repulsive states (particularly in the valence region), and understanding the subsequent electron and nuclear dynamics leading to desorption. In the case of ionic solids, a conceptually simple positive-ion desorption mechanism has been identified based on the reversal of the Madelung potential, following multiple ionization of a negative ion in the crystal[3,4]. Despite the fact that the repulsive character of such a state is beyond any doubt, both theoretical [5] and experimental [6] evidence does not always support a desorption mechanism based on Coulombic repulsion.
Function of Phospholipases

In the preceding chapters, descriptions of a wide variety of phospholipases have been covered. Emphasis has been placed on the characterization of these enzymes with emphasis on distribution, isolation, mechanism of action, and in a few instances, some reference was made to the function of the phospholipases in the metabolism of phospholipids. In general, those descriptions of function were limited to areas that have not been investigated extensively. The purpose of this chapter is to explore in greater depth some key areas of phospholipase function in which significant progress has been made or areas in which phospholipases have been used to study lipid and membrane composition.
Calcinosis in scleroderma.

Purpose of reviewTo provide an update on the available literature regarding the epidemiology, pathophysiology, diagnosis, and treatment of calcinosis cutis in patients with systemic sclerosis (SSc).Recent findingsWe identified observational studies that describe the frequency of calcinosis in SSc an
Risk-Based Reboot: New WHO Guidance for Laboratory Biosafety.

Over the past 30 years, the WHO has published 3 versions of the Laboratory Biosafety Manual to encourage the safe handling of pathogenic microorganisms in laboratories across the world. The manual has been broadly used in laboratories at all levels and biomedical sectors and is regarded as a de facto standard that represents best practices in biosafety. As technologies rapidly advance and our understanding of the potential threats and benefits to laboratory safety continue to evolve, so have our approaches to controlling exposure to pathogens. To address the current challenges relating to biological safety and security, revision and expansion of the manual toward the fourth edition are underway. In a recent article in Science by Kojima et al. (1), the authors discuss the proposed modifications …
Predication of NCAA Bracket Using Recurrent Neural Network and Combinatorial Fusion

In this study, we present a new framework for the prediction of bracket-based competitions, using the Men's NCAA Division 1 basketball championship tournament as an exemplar. The framework consists of the construction of a new classification model using recurrent neural network and the integration of this model with other machine learning models using combinatorial fusion. We first decide three preprocess steps for feature selection: transform the dataset, merge highly-correlated features, and select and order relevant features. Then the classification model, RNN*, leverages the differences in these factors between two teams to forecast the winning probabilities of each potential game. We also compare this new model with other four classic models, support vector machine (SVM), logistic regression (LOGIT), k-nearest neighbors (KNN) and random forest (RF), using the same features using the Log Loss function. Our results show that RNN has the best and most stable performance, with log loss score of 0.54 exceeding Seed-based benchmark method (0.59). Furthermore, we integrate these five models using combinatorial fusion which takes cognitive diversity between models into consideration. Results documented that in the 2016 competition, prediction accuracy rate increases from 70% for the best individual model to 75% for combined models.
Exploring problematic internet use among non-latinx black and latinx youth using the problematic internet use questionnaire-short form (PIUQ-SF)

Non-Latinx black and Latinx youth have reported more frequent Internet use compared to White youth, yet problematic Internet use among these groups of youth remains underexplored. This study aimed to validate the Problematic Internet Use Questionnaire-Short Form (PIUQ-SF) and investigate the characteristics of problematic Internet use among non-Latinx black and Latinx youth. Cross-sectional data were collected from a convenience sample of 235 high school students in Southeastern Florida (Mean Age = 16.1; 69.2% non-Latinx black; 27.4% Latinx). Psychometric analyses supported the reliability and construct validity of the PIUQ-SF among non-Latinx black and Latinx youth. Latent profile analyses revealed that 37.2% of non-Latinx black youth and 25.4% of Latinx youth were identified as having problematic Internet use. Multivariate regression analyses revealed that less parental monitoring was linked to higher levels of problematic Internet use among non-Latinx black and Latinx youth. Further, sleep problems were positively related to problematic Internet use among non-Latinx black youth. The present findings provide insight into the problematic Internet use among these understudied minority groups in the literature and have important implications for research and practice with non-Latinx black and Latinx youth.
Interface Between Occult Spinal Dysraphisms and Myelomeningoceles

“Spina bifida” presents as a variety of congenital defects from simple bony malfusion to open neural tube defects. The presentations and surgical management of these defects are very different, but both seek to detether the spinal cord. Although the embryology behind the occult and open forms of spinal dysraphism is very different, clinical management can be somewhat similar. Herein, we discuss the intersection between these pathological entities.
Kill the One-Shot: Using a Collaborative Rubric to Liberate the Librarian–Instructor Partnership

Subject faculty sometimes limit information literacy when they ask a librarian for “the library talk.” On the librarian’s end, this unimaginative request translates into a traditional one-shot, oft...
Serious leisure as a predictor of travel intentions and flow in motorcycle tourism

ABSTRACTThe current study uses structural equation modelling to examine the relationships between serious leisure, the flow state, and travel intentions among motorcycle tourists. Serious leisure c...
Live Action Role-Play as Pedagogy for Experiential Learning

Many professors and lecturers strive to structure educational experiences that facilitate engaged learning in university classrooms. While some lectures may fail to achieve this goal due to monoton...
Towards multiscale modeling of ocean surface turbulent mixing using coupled MPAS-Ocean v6.3 and PALM v5.0

Abstract. A multiscale modeling approach for studying the ocean surface turbulent mixing is explored by coupling an ocean general circulation model (GCM) MPAS-Ocean with the Parallelized Large Eddy Simulation Model (PALM). The coupling approach is similar to the superparameterization approach that has been used to represent the effects of deep convection in atmospheric GCMs. However, the focus of this multiscale modeling approach is on the small-scale turbulent mixing and their interactions with the larger-scale processes in the ocean, so that a more flexible coupling strategy is used. To reduce the computational cost, a customized version of PALM is ported on the general-purpose graphics processing unit (GPU) with OpenACC, achieving 10–16 times overall speedup as compared to running on a single CPU. Even with the GPU-acceleration technique, a superparameterization-like approach to represent the ocean surface turbulent mixing in GCMs using embedded high fidelity and three-dimensional large eddy simulations (LESs) over the global ocean is still computationally intensive and infeasible for long simulations. However, running PALM regionally on selected MPAS-Ocean grid cells is shown to be a promising approach moving forward. The flexible coupling between MPAS-Ocean and PALM allows further exploration of the interactions between the ocean surface turbulent mixing and larger-scale processes, as well as future development and improvement of ocean surface turbulent mixing parameterizations for GCMs.
Abstract P302: Neuroimaging Embolic Infarct Pattern in Work-Up For Embolic Source of Undetermined Etiology in Acute Ischemic Stroke

Introduction: Embolic infarct pattern on Neuroimaging as a marker for positive cardioembolism results in the work-up for Embolic Source of Undetermined Etiology (ESUS) in acute ischemic stroke (AIS...
Mean-Flow Measurements in the Boundary Layer and Wake and Wave Field of a Series 60 CB = 0.6 Ship Model—Part 2: Scale Effects on Near-Field Wave Patterns and Comparisons with Inviscid Theory

Part 2 of this two-part paper presents additional results from a towing-tank experiment conducted in order to explicate the influence of wavemaking by a surface-piercing body on its boundary-layer and wake and provide detailed documentation of the complete flow field appropriate for validating computational methods. In Part 1 (abstract no 93020378), wave profile, local and global wave-elevation, and mean-velocity and pressure field measurements for Froude numbers 0.16 and 0.316 for a 3.048 m Series 60 CB=0.6 hull form are presented and discussed to point out the essential differences between wavemaking and the boundary layer and wake. In part 2, scale effects on the near-field wave patterns are examined through wave profile and local and global wave-elevation measurements for 1.829 and 3.048 m models and Froude numbers 0.316, 0.3, and 0.25. The bow-wave amplitude and divergence angle are larger and the stern waves smaller for the smaller model. The latter scale effect is well known, but the former one is a new and unexpected result. Also, comparisons are made between the experimental results and those from a wavy inviscid-flow method, which provides an evaluation of the capabilities of the computational method. Although the computations predict the gross features of the wave system and velocity and pressure fields, they do not simulate the complex details of either the wave system of the flow field, especially close to the hull and wave centerplane.
Inhibition of inositol phosphate second messenger formation by intracellular loop one of a human calcitonin receptor: Expression and mutational analysis of synthetic receptor genes

Receptors for calcitonin (CTRs) have been cloned from several species, and two isoforms have been found to be expressed in human tissue. One human CTR isoform (hCTR-1) contains a 16-amino acid insertion in its first intracellular (I1) loop that is not present in porcine CTR (pCTR), rat CTR, or the other human CTR (hCTR-2). To facilitate the study of CTRs by mutational analysis, we have constructed synthetic hCTR-1 and hCTR-2 genes. Activation of hCTR-1 expressed transiently in COS-1 cells stimulates the formation of cAMP but not of inositol phosphates (IPs) whereas pCTR, a chimeric CTR in which the I1 loop of pCTR was substituted for the I1 loop of hCTR-1, and hCTR-2 stimulate cAMP and IP formation. A series of chimeric CTRs in which intracellular loops 1, 2, and 3 and the carboxyl tail of pCTR were substituted individually or in combination for those of hCTR-1 were constructed. All chimeras stimulated cAMP formation whereas chimeras containing the I1 loop of hCTR-1 with its 16-amino acid insertion were incapable of stimulating IP formation. There was no correlation between maximal stimulation of cAMP and IP formation by these CTRs. Thus, an inserted sequence in the I1 loop of hCTR-1 abolishes stimulation of the IP signal transduction pathway while allowing stimulation of the cAMP pathway.
Creating Fungal Pathway/Genome Databases Using Pathway Tools

Abstract The Pathway Tools software allows a group of scientists to create, update, and publish on the Web an evolving knowledge resource describing the genome and biochemical networks of the organism. Such a knowledge resource will minimize duplication of experimental effort, ensure that all relevant knowledge will be brought to bear on interpreting new experimental resulte, and permit system-level computational analyses. Creation of a new Pathway/Genome Database (PGDB) by Pathway Tools includes inference of fungal metabolic pathways and pathway hole fillers (genes that code for enzymes missing from predicted pathways). Pathway Tools also infers the transport reactions present in an organism. A collection of interactive editing tools allows refinement of a PGDB by adding or modifying gene functions or pathways to capture knowledge from the biomedical literature. Pathway Tools provides a variety of query and visualization capabilities including a genome browser, displays of biochemical pathways, and a visualization of the cellular biochemical network. The Omics Viewer paints multiple types of functional genomics data onto that cellular network diagram. Comparative genomics capabilities allow comparison with other fungal Pathway/Genome Databases.
Deletion of cytoplasmic sequences of the nerve growth factor receptor leads to loss of high affinity ligand binding

The nerve growth factor (NGF) receptor is a glycosylated transmembrane protein present on the cell surface as both high and low affinity forms, but biological responsiveness requires interactions of NGF with the high affinity site. We have tested the effects of mutations in the intracellular domain of the receptor upon its cell surface expression and equilibrium binding of 125I-NGF. Although mutant receptors lacking the entire cytoplasmic domain are processed and expressed at the cell surface and are capable of binding to NGF, the absence of cytoplasmic sequences leads to a loss of high affinity binding and to a lack of an appropriate cross-linking pattern as assessed by N-hydroxysuccinimidyl 4-azidobenzoate photoaffinity cross-linking. These results, taken together with the highly conserved nature of these cytoplasmic sequences, implies that the interaction of the receptor with an accessory molecule is necessary to form the high affinity receptor.
Unitarily Invariant Function Spaces

This chapter deals with a subject that is basically a topic in harmonic analysis and which, at first glance, may seem to have little to do with our principal concern, namely with holomorphic functions. Nevertheless, one of its main results (Theorem 12.3.6) will be essential later in the classification of Moebius-invariant spaces, an obviously function-theoretic topic.
Limbal conjunctival plaques and idiopathic eosinophilic conjunctivitis

Summary A 4-year-old Welsh pony crossbred gelding was examined for acute onset of blepharospasm, epiphora and corneal oedema. Ophthalmic examination identified 2 conjunctival plaques located near the superior limbus of the left eye. The plaques did not resolve following treatment with topical triple antibiotic ointment, topical atropine ointment and oral flunixin meglumine and therefore a conjunctival biopsy was performed. Histology of the biopsy resulted in a diagnosis of eosinophilic conjunctivitis, which was treated with a topical corticosteroid ointment. Plaques resolved after 73 days of therapy but lesions did not improve with concurrent treatment with anthelmintics early in the course of therapy. Failure to identify an aetiological agent led to a diagnosis of idiopathic eosinophilic conjunctivitis. The conjunctival plaques have not recurred in the 10 months following discontinuation of therapy.
Non-Gaussian Time Series Models

Non-Gaussian linear time series models are discussed. The ways in which they differ from Gaussian models are noted. This is particularly the case for prediction and parameter or transfer function estimation.
The taxonomic analysis of mass extinction intervals: An approach to problems of resolution as shown by Cretaceous ammonite genera (global) and species (Western Interior of the United States)

The application of diverse, yet basic, analytical metrics to high-resolution temporal and taxonomic data allows for precise documentation of ammonite origination, diversification, extinction, and turnover rates at the genus-substage and species-biozone level through mass extinction intervals. These dynamics are investigated for the entire Cretaceous for ammonites at the generic level, and during the highly dynamic Cenomanian-Turonian extinction interval at the specific level. A stepwise pattern of extinction can be interpreted from these data when investigated using high-resolution event stratigraphic techniques.
A comparison of file system workloads

In this paper, we describe the collection and analysis of file system traces from a variety of different environments, including both UNIX and NT systems, clients and servers, and instructional and production systems. Our goal is to understand how modern workloads affect the ability of file systems to provide high performance to users. Because of the increasing gap between processor speed and disk latency, file system performance is largely determined by its disk behavior. Therefore we primarily focus on the disk I/O aspects of the traces. We find that more processes access files via the memory-map interface than through the read interface. However, because many processes memory-map a small set of files, these files are likely to be cached. We also find that file access has a bimodal distribution pattern: some files are written repeatedly without being read; other files are almost exclusively read. We develop a new metric for measuring file lifetime that accounts for files that are never deleted. Using this metric, we find that the average block lifetime for some workloads is significantly longer than the 30-second write delay used by many file systems. However, all workloads show lifetime locality: the same files tend to be overwritten multiple times.
Want Young Readers? All it takes is Money, Time, Staff and Space : a Resource-Based View of Newspapers’ Strategies For Luring Kids and Teens to News

Abstract: The newspaper industry has long expressed a desire to attract more children and teenagers to their products. Attracting young readers, however, requires strategic decisions and resource allocation. The Resource-Based View (RBV) of strategic management suggests that newspapers must devote unique resources to creating or acquiring content that will attract young people. Using the RBV as a theoretical framework, this study surveys U.S. daily newspaper publishers about what resources (time, money and people) they are devoting to attract young readers. The study finds that few newspapers have truly made a full-time commitment to attracting young readers. Increasing resources should lead to increased performance in trying to reach young audiences. Key-words : newspaper industry, young readers, strategic management Resume : L’industrie de la presse ecrite s’est proposee depuis longtemps d’attirer plus d’enfants et d’adolescents a utiliser ses produits. Attirer les jeunes lecteurs, quand meme, demande des decisions strategiques et une allocation des ressources intelligente. L’approche centree sur les ressources ( Resource- Based View ) du management strategique suggere que les journaux doivent allouer des ressources uniques a la creation d’un contenu qui puisse attirer des jeunes gens. En utilisant l’approche centree sur les ressources comme cadre theorique, l’article interroge les editeurs des quotidiens des Etats-Unis sur les ressources (temps, argent, ressources humaines) qu’ils ont l’intention d’utiliser pour attirer les jeunes gens. La recherche montre que peu de journaux ont vraiment essaye d’attirer les jeunes lecteurs. Des ressources supplementaires devraient apporter plus de chances dans la tentative d’attirer de jeunes audiences. Mots cles : industrie de la presse ecrite, jeunes lecteurs, management strategique
Optimization of the operation of a gas terminal

Optimal operation of complex process plants requires the assistance of computer systems for day-to-day operation.
The Kingfish and His Realm: The Life and Times of Huey P. Long

Born in rural Winn Parish, Louisiana, Huey P. Long grew up to become the most influential governor the state of Louisiana has ever known. Indeed, he commanded a power base that ultimately made him virtual dictator of his home state. The story of Long's remarkable life, from his turn-of-the-century upbringing to his death at the hands of an assassin in 1935, fascinates students of Louisiana politics still. In The Kingfish and His Realm, William Ivy Hair carefully sets Long and his regime in the context of the history of Louisiana and the South. He provides both a new biography of Long and a thoroughgoing treatment of his social, political, and economic environment in light of the latest scholarship. The result is a view of Huey Long that dispels many of the myths that have surrounded him and also challenges T. Harry Williams' influential interpretation. Hair emphasises Huey's darker side, portraying him as a gifted, charismatic leader who craved power above all else, the more of it the better. From childhood, Long believed that he could become president of the United States, and almost all of his actions were taken with that goal in mind. By the early 1930s, he thought the presidency was within reach. The book's detailed and convincing picture of Louisiana as an impoverished, underdeveloped state rife with complex social and class-based tensions goes far toward explaining how this ruthless, supremely energetic, power-hungry man was able to realise such grand political dreams at so young an age. When the forty-two-year-old Long was gunned down on September 8, 1935, it ended his drive for the White House but not his influence in Louisiana. Even today, more than half a century after his death, when political pundits no longer speak in terms of Longs and anti-Longs, Huey remains a larger-than-life icon in the state, and the most controversial character in its colourful history. The Kingfish and His Realm may not end the controversy, but it does significantly enrich our understanding of Huey Long and his world.
Comments on the Scaling Behavior of Currents

Necessary and sufficient conditions in order for all components of a local operator (such as a current, for example) to have the same dimension are given and discussed. In addition, we then note that exact scale invariance is in an apparent formal contradiction with a definite scaling behavior for the currents. The solution of this contradiction is then traced back to the fact that in scale-invariant theories, the Schwinger term must be quadratically divergent. We finally conclude by briefly discussing Coleman's theorem for scale and conformal transformations.
Propagation of grid turbulence in homogeneous fluids

The purpose of this paper is to present the results of a laboratory experiment dealing with one‐dimensional propagation of a turbulent front induced by an oscillating grid in a homogeneous fluid. The symmetrical quadrupolar mode of the flow, induced by the grid elements, was studied in the range KC=4–45, S=1–20 (KC is the Keulegan–Carpenter number, S is the Stokes number). It is shown that the depth H of the turbulent layer increases with time t as H∝t1/2. Experimental data for different grid parameters and oscillation amplitudes and frequencies are presented in the nondimensional form h=const τ1/2, using nondimensional depth h of the turbulent layer and nondimensional time τ. A semiempirical model is presented to explain this behavior. This model is based on the properties of a flow induced in a visous fluid by localized forcing of a line force dipole (force doublet).
Chemical characterization of plywood veneer dryer emissions

Abstract The chemical composition of the plywood veneer dryer emissions from eight steam- or gas-heated mills in the U.S. were analyzed by flame ionization detection gas chromatography and gas chromatography-mass spectrometry. The feed stocks examined consisted of three Pacific Northwestern species and three Southern yellow pines. The composition and the amount of emissions have changed since a 1972 study. The bulk of emissions was gaseous, and 40–95 % of total emissions consisted of ten terpenes. Of 28 components in the condensable portion of the emissions, 13 were identified by name and 4 by functional group. Isopimaric, dehydroabietic and oleic acids were most common. Some emissions were contaminants present in the air before entry into the dryers. Gaseous dryer emissions are similar to the foliage emissions and the cortical oleoresin content of living trees. Non-gaseous emissions are similar to biogenic components in rural aerosols and in wood extracts.
Enzyme activities in the Delaware Estuary affected by elevated suspended sediment load

Abstract Extracellular enzyme activities were compared among surface water, bottom water, and sediments of the Delaware Estuary using six fluorescently labeled, structurally distinct polysaccharides to determine the effects of suspended sediment transport on water column hydrolytic activities. Potential hydrolysis rates in surface waters were also measured for the nearby shelf. Samples were taken in December 2006, 6 months after a major flood event in the Delaware Basin that was followed by high freshwater run-off throughout the fall of 2006. All substrates were hydrolyzed in sediments and in the water column, including two (pullulan and fucoidan) that previously were not hydrolyzed in surface waters of the Delaware estuary. At the time of sampling, total particulate matter (TPM) in surface waters at the lower bay, bay mouth, and shelf ranged between 31 mg l −1 and 48 mg l −1 and were 2 to 20 times higher than previously reported. The presence of easily resuspended sediments at the lower bay and bay mouth indicated enhanced suspended sediment transport in the estuary prior to our sampling. Bottom water hydrolysis rates at the two sites affected by sediment resuspension were generally higher than those in surface waters from the same site. Most notably, fucoidan and pullulan hydrolysis rates in bay mouth bottom waters were 22.6 and 6.2 nM monomer h −1 , respectively, and thus three and five times higher than surface water rates. Our data suggest that enhanced mixing processes between the sediment and the overlying water broadened the spectrum of water column hydrolases activity, improving the efficiency of enzymatic degradation of high molecular weight organic matter in the water with consequences for organic matter cycling in the Delaware estuary.
Extension of the Learning Curve — Some Empirical Results

The learning curve or start-up model is extended to three examples of labour-intensive manufacture-automobile assembly, apparel manufacture and the production of large musical instruments. Prediction of the parameters of the model and the occurrence of steady-state "plateaux" are examined in relation to the findings. The results of the investigation suggest the wider applicability of the learning curve model in labour-intensive industries, provide additional data to evaluate an empirical approach to parameter prediction and demonstrate the difficulty of generalizing about the occurrence and predictability of steady-state plateaux. In addition, the application of different cost indices in learning curve research is demonstrated among new product start-ups in both single and multiple facilities.
X-ray Resonance Exchange Scattering (XRES)

Large resonant magnetization-sensitive X-ray scattering is predicted to occur in the vicinity of the LII, LIII, MII-MV absorption edges in the rare earth and actinide elements, and at the LII, LIII edges in the transition and 4d elements. Additional longer wavelength resonances will occur in the actinides and 4d elements. These “magnetic” resonances result from electric multipole transitions, with the sensivity to the magnetization arising from exchange and spin-orbit correlations. For some transitions, the magnetic scattering will be comparable to the charge scattering.