cssi/SciSciGPT-SciSciNet huggingface dataset:
Dispersal of Amblyseius swirskii (Acari: Phytoseiidae) on High-Tunnel Bell Peppers in Presence or Absence of Polyphagotarsonemus latus (Acari: Tarsonemidae).

Amblyseius swirskiiAthias-Henriot (Acari: Phytoseiidae) is a predatory mite used to control thrips (Thysanoptera), whiteflies (Bemisia tabaci Genn., Hemiptera: Aleyrodidae), and broad mites (BMs) (Polyphagotarsonemus latus Banks, Acari: Tarsonemidae). Dispersal of A. swirskii, using the ornamental pepper "Explosive Ember" as a banker plant was evaluated for control of BMs in high-tunnel peppers. Open-canopy plants (5 weeks old) versus closed-canopy plants (10-weeks old) were used to evaluate the effect of plant connectedness in A. swirskii dispersal, in the presence (two females per plant) and absence of BMs. Plots consisted of a single central banker plant and four bell peppers extending linearly north and south. Sets of all treatments were destructively sampled 1, 4, and 7 days after releasing A. swirskii Within 24 h, A. swirskii dispersed four plants away from the banker plants (1 m), regardless of the state of the canopy. Canopy connectedness did increase the presence of A. swirskii on the crop plants. Predatory mite numbers on closed-canopy treatments doubled within the 7-day sampling period, whereas no significant increase was observed on open-canopy treatments. The presence of BMs had no significant effect on the movement of A. swirskii The results suggest further experiments with A. swirskii and banker plants for control of BMs is warranted.
Leading-Following in the Context of Rural Nursing

Leading-following, as defined by Parse, is "deliberately innovating with potent engaging in persistently pursuing excellence. It is an indivisible, unpredictable, ever changing cocreation." Parse noted that processes forming the essence of leading-following require commitment, risk-taking, acknowledging ambiguity, respecting others, and vigilance. There is a bond between members of society and nurses-an expectation that nurses will provide care to individuals, families, and communities. Nursing is a profession where the potential to create meaning in healthcare has not yet been fully realized.
Balls on walls, feet on streets: Subversive play in Grand Ducal Florence

This article draws attention to the social and political import of balls games and acts of play in the urban space of Grand Ducal Florence. At the same time that the Medici were commissioning artworks that rhetorically promoted a unified identity of Florence and a spectre of control over the city space through the apparatus of public games like calcio in livrea, young men engaged in transitory activities of play in the street that contributed to community identity and belonging in space. Teasing out the transgressive and political potential of the ludic apart from and apart of the festal demonstrates how games in the city produced moments of community in an early modern public sphere- a sphere carved out through use of and performance in urban space, a sphere sometimes contending with and in contention with legislation, control, and authority by the Grand Duchy. Play shaped the production, use, and meaning of the urban environment both in daily life and during special events. In turn, the city's socially invested topography contributed to the construction of Florentine identity, within, between, and beyond factions.
Tight-binding methods for general longitudinally driven photonic lattices -- edge states and solitons

A systematic approach for deriving tight-binding approximations in general longitudinally driven lattices is presented. As prototypes, honeycomb and staggered square lattices are considered. Time-reversal symmetry is broken by varying and/or rotating the waveguides, longitudinally, along the direction of propagation. Different sublattice rotation and structure are allowed. Linear Floquet bands are constructed for intricate sublattice rotation patterns such as counter-rotation, phase offset rotation, as well as different lattice sizes and frequencies. An asymptotic analysis of the edge modes, valid in a rapid-spiraling regime, reveals linear and nonlinear envelopes which are governed by linear and nonlinear Schr\"odinger equations, respectively. Nonlinear unidirectional edge modes, referred to as topologically protected edge solitons, are identified. Direct numerical simulations for both the linear and nonlinear edge states agree with asymptotic theory. Topologically protected modes are found; they possess unidirectionality and do not scatter at lattice defect boundaries.
Modern diagnosis and treatment of hiatal hernias

Hiatal hernias are a common finding on radiographic or endoscopic studies. Hiatal hernias may become symptomatic or, less frequently, can incarcerate or become a volvulus leading to organ ischemia. This review examines latest evidence on the diagnostic workup and management of hiatal hernias. A literature review of contemporary and latest studies with highest quality of evidence was completed. This information was examined and compiled in review format. Asymptomatic hiatal and paraesophageal hernias become symptomatic and necessitate repair at a rate of 1% per year. Watchful waiting is appropriate for asymptomatic hernias. Symptomatic hiatal hernias and those with confirmed reflux disease require operative repair with an anti-reflux procedure. Key operative steps include the following: reduction and excision of hernia sac, 3 cm of intraabdominal esophageal length, crural closure with mesh reinforcement, and an anti-reflux procedure. Repairs not amenable to key steps may undergo gastropexy and gastrostomy placement as an alternative procedure. Hiatal hernias are commonly incidental findings. When hernias become symptomatic or have reflux disease, an operative repair is required. A minimally invasive approach is safe and has improved outcomes.
Tuberculosis re-treatment after exclusion of rifampicin resistance.

Once rifampicin resistance is excluded, it might be wiser to use the category II regimen in TB retreatmenthttp://ow.ly/KLJE30hDX0I
Enantioselective Synthesis of anti-1,2-Diamines by Cu-Catalyzed Reductive Couplings of Azadienes with Aldimines and Ketimines.

Here we report highly efficient and chemoselective azadiene–imine reductive couplings catalyzed by (Ph-BPE)Cu–H that afford anti-1,2-diamines. In all cases, reactions take place with either aldimine or ketimine electrophiles to deliver a single diastereomer of product in >95:5 er. The products’ diamines are easily differentiable, facilitating downstream synthesis.
The Correctness of a Simple Optimizing Expression Compiler

This chapter presents the application of the theory and proof techniques to establish the correctness of an algorithm for converting expressions such as (PLUS (QUOTIENT X 2) (TIMES X (TIMES Y Z ))) into a sequence of instructions, such as might be executed by a digital computer to compute the value of the expression in an environment in which X, Y, and Z have numeric values. The algorithm is a very simple example of an important class of algorithms known as compilers. A compiler is just a translator from a high-level programming language to a machine language. The chapter illustrates the basic idea of an expression compiler by describing the way by which a certain pocket calculator might be used to evaluate arithmetic expressions. It also highlights the ability to optimize an expression and generate correct code for forms in general.
EXAFS Studies of Anharmonic Solids

EXAFS spectroscopy is a sensitive probe of atomic pair distribution functions (PDF’s) and a useful tool for studying the anharmonic, as well as the harmonic, part of interatomic potentials.
Lifespan Extension by the Antioxidant Curcumin in Drosophila Melanogaster

The interest in health benefits associated with consumption of anti-oxidants has led to investigations examining the possibility that diets rich in anti-oxidants promote lifespan extension. Studies using the standard fruit fly (Drosophila melanogaster) model of longevity have shown that the antioxidants vitamin E and N-acetyl cysteine prolong lifespan. Turmeric is a spice which has been consumed and used for medicinal purposes for many centuries in Asia. Interestingly, turmeric contains the powerful antioxidant, curcumin. To test the hypothesis that dietary curcumin prolongs lifespan, groups of 30 male D. melanogaster were cultured on media containing 1) no additive; 2) 0.5 mg of curcumin/gram of media; 3) 1.0 mg of curumin/gram of media; 4) 1.0μg of the superoxide dismutase inhibitor, disulfiram/gram of media; 5) 10 g of disulfiram/gram of media; 6) 0.5 mg curcumin and 1.0 g disulfiram/ gram of media; 7) 1.0 mg curcumin and 1.0 g disulfiram/ gram of media; 8) 0.5 mg curcumin and 10 g disulfiram/gram of media; or 9) 1.0 mg curcumin and 10 g disulfiram/gram of media. The number of live fruitflies was noted daily and mean lifespan determined for each treatment group. A significant (P≤0.05) increase in mean lifespan was noted only for the fruitflies maintained on 1.0 mg of curcumin/gram of media; this effect was reversed by addition of disulfiram. These results demonstrate that dietary curcumin prolongs lifespan and that this effect is associated with enhanced superoxide dismutase activity.
Ectopic pregnancy after hysteroscopic tubal occlusion confirmed by hysterosalpingogram: a case report.

BACKGROUND Even after demonstrated bilateral tubal occlusion during posthysteroscopic sterilization hysterosalpingogram (HSG), incorrect location of the micro-inserts can result in unplanned pregnancy and potential ectopic location. CASE More than 4 years after HSG-confirmed hysteroscopic tubal occlusion, a patient presented with pelvic both absenceboh absence cy test. Surgical and pathologic evaluation ultimately revealed an ectopic pregnancy of likely cornual location. Review of her HSG confirmed bilateral tubal occlusion, but the location of one micro-insert was incorrect. CONCLUSION Ectopic pregnancy after HSG-confirmed tubal occlusion is a rare event. Necessary measures to prevent this from occurring include not only confirmation of bilateral tubal occlusion, but also recognition of correct location of the micro-insert within the lumen of the fallopian tube. If the postprocedure HSG demonstrates incorrect micro-insert position, even in the absence of tubal dye spill, the patient cannot rely on this method for sterilization.
Congenital erythropoietic porphyria and erythropoietic protoporphyria: Identification of 7 uroporphyrinogen III synthase and 20 ferrochelatase novel mutations.

Abstract The erythropoietic porphyrias are inborn errors of heme biosynthesis with prominent cutaneous manifestations. They include autosomal recessive Congenital Erythropoietic Porphyria (CEP) due to loss-of-function (LOF) mutations in the Uroporphyrinogen III Synthase (UROS) gene, Erythropoietic Protoporphyria (EPP) due to LOF mutations in the ferrochelatase (FECH) gene, and X-Linked Protoporphyria (XLP) due to gain-of-function mutations in the terminal exon of the Aminolevulinic Acid Synthase 2 (ALAS2) gene. During the 11-year period from 01/01/2007 through 12/31/2017, the Mount Sinai Porphyrias Diagnostic Laboratory provided molecular diagnostic testing for one or more of these disorders in 628 individuals, including 413 unrelated individuals. Of these 628, 120 patients were tested for CEP, 483 for EPP, and 331 for XLP, for a total of 934 tests. For CEP, 24 of 78 (31%) unrelated individuals tested had UROS mutations, including seven novel mutations. For EPP, 239 of 362 (66%) unrelated individuals tested had pathogenic FECH mutations, including twenty novel mutations. The IVS3-48 T > C low-expression allele was present in 231 (97%) of 239 mutation-positive EPP probands with a pathogenic FECH mutation. In the remaining 3%, three patients with two different FECH mutations in trans were identified. For XLP, 24 of 250 (10%) unrelated individuals tested had ALAS2 exon 11 mutations. No novel ALAS2 mutations were identified. Among family members referred for testing, 33 of 42 (79%) CEP, 62 of 121 (51%) EPP, and 31 of 81 (38%) XLP family members had the respective family mutation. Mutation-positive CEP, EPP, and XLP patients who had been biochemically tested had marked elevations of the disease-appropriate porphyrin intermediates. These results expand the molecular heterogeneity of the erythropoietic porphyrias by adding a total of 27 novel mutations. The results document the usefulness of molecular testing to confirm the positive biochemical findings in these patients and to identify heterozygous family members.
Efficiency Improvement of Fault-Tolerant Three-Level Power Converters

Fault-tolerant power converters play a critical role in the transportation electrification. However, fault-tolerant operation, high efficiency, and low cost usually result in design criteria that have conflicting constraints and goals. The majority of the fault-tolerant power converter topologies presented in the literature confirm these conflicts. In this paper, three types of fault-tolerant neutral-point clamped (NPC) converters are investigated. Various modulation strategies are explored to reduce the losses of the redundant phase leg. The simulation and experimental results show that the Switching Frequency Optimal Phase opposition Disposition modulation strategy is the most effective approach in minimizing the losses in the redundant phase leg.
Experimental Study of the Mechanics of Blast-Induced Traumatic Brain Injury

Blast-induced traumatic brain injury (bTBI) has become a “signature wound” of modern combat due to the expansive use of improvised explosive devices (IED). bTBI is characterized as either primary, secondary, tertiary, or quanternary.
Thermal Conductivity of Polyvinylidene Fluoride Membranes for Direct Contact Membrane Distillation

Abstract Direct contact membrane distillation (DCMD) is a promising desalination technology for locations where low-cost energy (e.g., waste heat or geothermal energy) is readily available. Modelin...
LipoGlo: A sensitive and specific reporter of atherogenic lipoproteins

ABSTRACT Apolipoprotein-B (APOB) is the structural component of atherogenic lipoproteins, lipid-rich particles that drive atherosclerosis by accumulating in the vascular wall. As atherosclerotic cardiovascular disease is the leading cause of death worldwide, there is an urgent need to develop new strategies to prevent lipoproteins from causing vascular damage. Here we report the LipoGlo system, which uses a luciferase enzyme (NanoLuc) fused to ApoB to monitor several key determinants of lipoprotein atherogenicity including particle abundance, size, and localization. Using LipoGlo, we are able to comprehensively characterize the lipoprotein profile of individual larval zebrafish and collect the first images of atherogenic lipoprotein localization in an intact organism. We discover multiple unexpected extravascular lipoprotein localization patterns, as well as identify pla2g12b as a potent regulator of lipoprotein size. ApoB-fusion proteins thus represent a uniquely sensitive and specific approach to study atherogenic lipoproteins and their genetic and small molecule modifiers.
Paper-boat relaxion

A new relaxion mechanism is proposed where a small electroweak scale is preferably selected earlier than the larger one due to a potential instability, which is different from previously proposed stopping mechanisms by either Hubble friction from an increasing periodic barrier or thermal friction from gauge boson production. The sub-Planckian field excursion of an axion can be achieved without violating the bound on the e-folding number from a quantum gravity perspective; our relaxion can be identified as a QCD axion, preserving the Peccei-Quinn solution to the strong CP problem as well as making up all the cold dark matter in our current Universe.
A Framework for Collaborative Learning in Secure High-Dimensional Space

As the amount of data generated by the Internet of the Things (IoT) devices keeps increasing, many applications need to offload computation to the cloud. However, it often entails risks due to security and privacy issues. Encryption and decryption methods add to an already significant computational burden. In this paper, we propose a novel framework, called SecureHD, which provides a secure learning solution based on the idea of high-dimensional (HD) computing. We encode original data into secure, high-dimensional vectors. The training is performed with the encoded vectors. Thus, applications can send their data to the cloud with no security concerns, while the cloud can perform the offloaded tasks without additional decryption steps. In particular, we propose a novel HD-based classification algorithm which is suitable to handle a large amount of data that the cloud typically processes. In addition, we also show how SecureHD can recover the encoded data in a lossless manner. In our evaluation, we show that the proposed SecureHD framework can perform the encoding and decoding tasks 145.6× and 6.8× faster than a state-of-the-art encryption/decryption library running on the contemporary CPU. In addition, our learning method achieves high accuracy of 95% on average for diverse practical classification tasks including cloud-scale datasets.
Game of hypocrites: Beurs break silence in Faïza Guène’s Kiffe kiffe demain:

This article analyses the cultural crisis of beur youth by calling attention, in Faiza Guene’s novel, Kiffe kiffe demain (2004), to how Maghrebi immigrants as well as the French state attempt to ma...
1165 Degree of Trendelenburg Position Required for Robotic Assisted Laparoscopic Gynecologic Surgery

Study Objective To elucidate the range of Trendelenburg position required for benign robotic (computer) assisted gynecologic surgery. Design Descriptive study. Setting A surgeon at our institution (an academic tertiary care center) routinely placed patients in the minimal amount of Trendelenburg necessary to expose the target anatomy, measured the degree with a smart phone app and documented the degree in operative reports. Patients or Participants All robotic cases from November 1, 2011 through July 31, 2018. Interventions N/A Measurements and Main Results 338 out of 380 identified cases had Trendelenburg degrees recorded. Mean Trendelenburg was 15.4 degrees (range from 7 to 31). 85% of cases (287/338) were completed with 18 degrees or less of Trendelenburg. Addition of Modifier 22 billing code (signifying a more complicated surgery) was associated with higher mean Trendelenburg of 16.0 (n=83; range 9-30) compared to 15.2 (n= 255; range 7-31) for normal coding (p=0.05). Higher BMI was associated with higher mean Trendelenburg from 15.0 (n=218; range 7-25) for BMI less than 30 to 16.3 (n=120; range 9-31) for BMI greater than 30 (p=0.001). Surgeries that included hysterectomy (mean Trendelenburg 15.4, n=309, range 7-31) showed no difference compared with other gynecologic procedures (mean Trendelenburg of 15.3; n=29, range 10-30) (p=0.9). For hysterectomy cases, increasing uterine weight was associated with increasing degree of Trendelenburg. Uteri less than 250 g required 15.2 degrees (n=217; range 7-31), uteri from 250-499g required 15.7 (n=59; range 8-24), and uteri greater than 500g required 16.75 degrees (n=32, range 8-25) which is statistically different as compared to those under 250g (p=0.02) Conclusion Steep Trendelenburg is not always needed for gynecologic surgery. The majority of cases can be accomplished with less than 18 degrees of Trendelenburg. BMI, case difficulty and uterine size were associated with requiring steeper Trendelenburg. We recommend personalized positioning by placing the patient in the minimal amount of Trendelenburg required to adequately expose the target anatomy.
Atypical anorexia nervosa can be just as bad

The case report and literature review by Rastogi and Rome in this issue[1][1] reminds us that eating disorders can occur in patients with a wide variety of weights and that those who were previously overweight present differently from those with classic anorexia nervosa. The case presented meets the
Inelastic scattering dynamics of naphthalene and 2-octanone on highly oriented pyrolytic graphite.

The inelastic scattering dynamics of the isobaric molecules, naphthalene (C10H8) and 2-octanone (C8H16O), on highly oriented pyrolytic graphite (HOPG) have been investigated as part of a broader effort to inform the inlet design of a mass spectrometer for the analysis of atmospheric gases during a flyby mission through the atmosphere of a planet or moon. Molecular beam–surface scattering experiments were conducted, and the scattered products were detected with the use of a rotatable mass spectrometer detector. Continuous, supersonic beams were prepared, with average incident translational energies, ⟨Ei⟩, of 247.3 kJ mol−1 and 538.2 kJ mol−1 for naphthalene and 268.6 kJ mol−1 and 433.8 kJ mol−1 for 2-octanone. These beams were directed toward an HOPG surface, held at 530 K, at incident angles, θi, of 30°, 45°, and 70°, and scattered products were detected as functions of their translational energies and scattering angles. The scattering dynamics of both molecules are very similar and mimic the scattering of atoms and small molecules on rough surfaces, where parallel momentum is not conserved, suggesting that the dynamics are dominated by a corrugated interaction potential between the incident molecule and the surface. The effective corrugation of the molecule–surface interaction is apparently caused by the structure of the incident molecule and the consequent myriad available energy transfer pathways between the molecule and the surface during a complex collision event. In addition, the HOPG surface contributes to the corrugation of the interaction potential because it can absorb significant energy from collisions with incident molecules that have high mass and incident energy. Small differences in the scattering dynamics of the two molecules are inferred to arise from the details of the molecule–surface interaction potential, with 2-octanone exhibiting dynamics that suggest a slightly stronger interaction with the surface than naphthalene. These results add to a growing body of work on the scattering dynamics of organic molecules on HOPG, from which insight into the hypervelocity sampling and analysis of such molecules may be obtained.
Global cost/quality management across multiple applications

Approximation is a technique that optimizes the balance between application outcome quality and its resource usage. Trading quality for performance has been investigated for single application scenarios, but not for environments where multiple approximate applications may run concurrently on the same machine, interfering with each other by sharing machine resources. Applying existing, single application techniques to this multi-programming environment may lead to configuration space size explosion, or result in poor overall application quality outcomes. Our new RAPID-M system is the first cross-application con-figuration management framework. It reduces the problem size by clustering configurations of individual applications into local"similarity buckets". The global cross-applications configuration selection is based on these local bucket spaces. RAPID-M dynamically assigns buckets to applications such that overall quality is maximized while respecting individual application cost budgets.Once assigned a bucket, reconfigurations within buckets may be performed locally with minimal impact on global selections. Experimental results using six configurable applications show that even large configuration spaces of complex applications can be clustered into a small number of buckets, resulting in search space size reductions of up to 9 orders of magnitude for our six applications. RAPID-M constructs performance cost models with an average prediction error of ≤3%. For our application execution traces, RAPID-M dynamically selects configurations that lower the budget violation rate by 33.9% with an average budget exceeding rate of 6.6% as compared to other possible approaches. RAPID-M successfully finishes 22.75% more executions which translates to a 1.52X global output quality increase under high system loads. Theo verhead ofRAPID-Mis within≤1% of application execution times.
Simposio 9: Manejo diabetológico del paciente con hígado graso pensando en la pandemiao

Symposium 9: Hepatic involvement in diabetes: beyond the liver Diabetes management of the patient with fatty liver thinking about the pandemic In the last years, we have witnessed great advances in pharmacological treatments for patients with type 2 diabetes (T2D). Due to a higher availability of therapeutic options, choosing a pharmacological treatment requires an exhaustive analysis of the clinical characteristics of each patient. The presences of cardiovascular diseases, heart failure, chronic kidney disease and hypoglycemia risk are the most important considerations when choosing the best therapeutic option for the T2D patient. Unfortunately, the presence of non-alcoholic fatty liver (NAFLD) is a complication of T2D that is frequently overlooked by the healthcare team and its presence could lead to therapeutic implications. Patients with T2D not only show a higher risk of developing NAFLDs, but they also show a higher progression to severe forms of the disease, including advanced liver fibrosis, cirrhosis and hepatocellular carcinoma. Epidemiologic studies estimate that around a 55% of the patients with T2D have NAFLD, and, from that figure, a 70% have the form with inflammation and necrosis, known as non-alcoholic steatohepatitis (NASH). As a consequence of the increase of obesity and T2D prevalence in the world, NASH has become the second most frequent cause of liver transplant, and will probably soon consolidate as the first cause. We are facing a pandemic; a real problem for public health.
Turbulent mixing and trajectories of jets in a supersonic cross-flow with different injectants

We investigate flow fields and trajectories of sonic jets in a supersonic cross-flow with different injectant properties. The cross-flow is held at a fixed condition with Mach number 1.71, static temperature and for thin boundary layers, the momentum flux ratio plays a more dominant role. The results in this study can guide the design of injection systems for supersonic applications and improve prediction of jet trajectories.
Surgical debulking improves survival in high-grade serous carcinoma regardless of platinum sensitivity

Objectives: We aimed to assess whether patients who underwent primary optimal cytoreduction experienced improved survival regardless of platinum sensitivity. Methods: We performed a retrospective, case-control study using our institution's ovarian cancer database to evaluate the effect of optimal cytoreduction on advanced stage, high grade serous ovarian cancer. Patients’ characteristics were compared using logistic regression and both univariate and multivariate Cox-proportional hazard regression. Validation of the model was then performed within The Cancer Genome Atlas (TCGA) database. Download : Download high-res image (364KB) Download : Download full-size image Results: A total of 470 patients were assessed for inclusion. A total of 234 patients were included as responders to chemotherapy and 98 were included as non-responders. Significant survival characteristics were identified and included in the multivariate analysis. Figure 2 demonstrates independent predictors of survival. Kaplan-Meier survival curves showed improved survival both for patients who were responders to chemotherapy as well as optimal cytoreduction (Figure 3; p Conclusions: Our analysis shows that patients who undergo primary optimal cytoreduction have a survival benefit regardless of their response to chemotherapy. Our model is well-validated within the TCGA database. Therefore, optimal primary cytoreduction should be considered, even in patients with advanced disease. If we are able to someday predict whether or not patients will respond to chemotherapy, cytoreductive surgery should still be considered a part of the treatment of non-responders.
Antiepileptic Drug (AED) Treatment in Juvenile Myoclonic Epilepsy (JME): a Population-based Study (2712)

Objective: To examine the prevalence of intractable Juvenile Myoclonic Epilepsy (JME) and to investigate differences in antiepileptic drugs (AEDs) treatment between persons with and without intractability. Background: Most JME are considered to be responsive to appropriate AEDs. However, little is reported about AED treatment patterns, such as treatment regimen and doses. Design/Methods: We performed a population-based study using a U.S. nationwide claims database from the OptumO ClinformaticsO Data Mart (10/2015–12/2017). JME cases were identified by ICD-10-CM diagnosis codes. We analyzed 22 AEDs. Outcomes were the frequency of intractable JME and differences in treatment regimen (i.e., monotherapy, polytherapy, and switched regimen) and doses (i.e., lower and higher than defined daily doses measured by prescribed daily dose (PDD)/defined daily dose (DDD) ratio) between persons with and without intractability, controlling for demographic characteristics, socioeconomic status, and psychiatric comorbidity. Results: Among 1530 persons with JME (median [IQR] age=26 [9–37] years; female=915 [59.8%]), 313 (20.5%) had intractability. AEDs were prescribed in 1406 (91.9%). Monotherapy was prevalent in non-intractable JME relative to intractable JME (63.0% vs. 37.8%, p=0.000). Polytherapy and switched regimen were frequently prescribed in both non-intractable (19.2% and 17.8%) and intractable JME (27.1% and 35.1%). After controlling for age, sex, race, education level, household incomes, and psychiatric comorbidity, persons with intractable JME were more likely to undergo polytherapy (OR=2.4, 95% CI=1.2–4.7, p=0.013) and switched regimen (OR=2.5, 95% CI=1.3–4.9, p=0.009). High-dose ratio (PDD/DDD>1) was prevalent in most commonly prescribed 5 AEDs for both non-intractable and intractable JME: levetiracetam (40.6% vs. 58.6%, p=0.000), lamotrigine (51.7% vs. 63.3%, p=0.033), valproic acid (13.6% vs. 20.8%, p=0.153), zonisamide (66.9% vs. 76.6%, p=0.234), and topiramate (16.0% vs.36.2%, p=0.010). Conclusions: Polytherapy, switched regimen, as well as high-dose AEDs were frequently applied for JME treatment regardless of intractability. This finding suggests that JME is less likely to have a benign course. Disclosure: Dr. Oh has nothing to disclose. Dr. Kim has nothing to disclose.
Physics and Dynamics of Clouds and Precipitation

Preface 1. Observation of clouds 2. The shape and size of cloud and precipitation particles 3. Molecular structures of water substance 4. Bulk thermodynamic equilibrium among water vapor, liquid water, and ice 5. Surface thermodynamics of water substance 6. Aerosol in the atmosphere 7. Nucleation 8. Hydrodynamics of cloud and precipitation particles 9. Diffusion growth and evaporation of cloud and precipitation particles 10. Collision, coalescence, break-up and melting 11. Cloud drop population dynamics in warm rain process 12. Fundamental cloud dynamics 13. Numerical cloud models 14. Cloud electricity 15. Clouds-environment interaction References Index.
Trend Analysis Techniques to Assist School Leaders in Making Critical Curriculum and Instruction Decisions

As educational needs of students change in response to changing demographics, economic factors, workforce needs, and school accountability requirements, school leaders must continually monitor and adjust curricula and associated methods of instructional delivery to increase student learning. The analysis of student performance data is a critical component of curriculum decision-making processes, and the purpose of this study is to demonstrate an application of trend analysis techniques in making curriculum and instruction decisions using historical student performance data. The techniques are demonstrated in relation to a real school problem and are transferrable to similar problems facing other schools. This study underscores the importance school leaders should place on analyzing data when making decisions related to curriculum and instruction.
La Làmina complementària "Arbre"del test PN en Corman

This work consists of a study of the picture Tree (La Courte Echelle) wich was added to Dr. Corman's Adventures of Black Leg Test in 1978, with the intention of increasing the number of pictures in which the father- figure is present, but about wich picture no published data exists. In a sample of 85 subjects, the themes of the picture are analysed, as well as the preferences identification and especially its apperceptive particularities in terms of the sex variable. The results support the author's expectations, since Tree contributes to the knowledge of the role of the paternal figure within the family, by means of the Black Leg Test.
Do residual earnings price ratios explain cross-sectional variations in stock returns?

Purpose – Variations in price/earnings (P/E) ratios are explained in a rational expectations framework by a number of fundamental factors, such as differences in growth expectations and risk. The purpose of this paper is to use a regression model and data from four sample periods (1996, 2000, 2001, and 2008) to separate the earnings/price (E/P) ratio into two parts – the portion of E/P that is related to fundamental determinants and a residual portion that cannot be explained by fundamentals. The authors use the residual portion as an indicator of over or undervaluation; a large negative residual is consistent with overvaluation while a large positive residual implies undervaluation. The authors find that stocks with larger negative residuals are associated with lower subsequent returns and reward-to-risk ratio, while stocks with larger positive residuals are associated with higher subsequent returns and reward-to-risk ratio. This pattern persists for both one and two-year holding periods. Design/methodol...
Framing a National Narrative: The Legend Collections of Peter Christen Asbjørnsen

Reviewed Medium: book Authors: Marte Hvam Hult Year: 2003 Pages: 208 Publisher: Wayne State University Press ISBN: 0-8143-3006-1 Prices: $34.95 US
Model Correlates Many Factors to Undergraduates' Perceived Importance of Library and Research Activities, but Low Explanation Power Suggests More Research Needed

A Review of: Soria, K. M. (2013). Factors predicting the importance of libraries and research activities for undergraduates. Journal of Academic Librarianship, 39(6), 464-470. Objective – The purpose is to analyze characteristics and perceptions of undergraduate students to determine factors that predict the importance of library and research activities for the students. Design – Student Experience in the Research University (SERU) survey questionnaire. Setting – Nine large, public, research universities in the United States of America. Subjects – 16,778 undergraduates who completed the form of the survey that included the academic engagement module questions. Methods – The researcher used descriptive and inferential statistics to analyze student responses. Descriptive statistics included coding demographic, collegiate, and academic variables, as well as student perceptions of the importance of library and research activities. These were used in the inferential statistical analyses. Ordinary least squares regression and factor analysis were used to determine variables and factors that correlated to students’ perceptions of the importance of libraries and research activities. Main Results – The response rate for the overall SERU survey was 38.1%. The results showed that the majority of students considered having access to a “world-class library collection,” learning research methods, and attending a university with “world-class researchers” to be important. The regression model explained 22.7% of variance in the importance students placed on libraries and research activities; factors important to the model covered demographics, collegiate, and academic variables. Four variables created in factor analysis (academic engagement, library skills, satisfaction with libraries and research, and faculty interactions) were significantly correlated with the importance students placed on libraries and research activities. The most important predictors in the model were: student satisfaction, interest in a research or science profession, interest in medical or health-related profession, academic engagement, and academic level. Conclusion – Based on the results of this study, librarians should be able to tailor their marketing to specific student groups to increase the perception of importance of libraries by undergraduates. For example, more success may be had marketing to students who are Hispanic, Asian, international, interested in law, psychology or research professions as the study found these students place more importance on libraries and research activities than other groups. These students may be targeted for being peer advocates for the libraries. Further research is suggested to more fully understand factors that influence the value undergraduate students place on libraries and find ways to increase the value of libraries and research activities for those demographic groups who currently rate the importance lower.
Can third-party payments benefit the principal?: The case of soft dollar brokerage

Abstract In a typical soft dollar arrangement, a security broker provides an institutional portfolio manager with credits to buy research from independent vendors in consideration for the manager's promise to send the broker premium commission business when trading his portfolio securities. Because portfolio investors implicitly pay for brokerage, critics argue soft dollars reflect a breach of loyalty in which the manager unjustly enriches himself by shifting to investors the research bill he should pay out of his own pocket. We hypothesize, to the contrary, that by paying the manager's research bill up-front the broker posts a quality-assuring performance bond that efficiently subsidizes the manager's investment research. Our database of private money managers shows premium commissions are positively related to risk-adjusted performance, suggesting soft dollars benefit investors. Premium commissions are also positively related to management fees, suggesting soft dollars are not a pure wealth transfer from investors that is competed away in the managerial labor market.
A Financial Health Index for Achieving Nonprofit Financial Sustainability

This paper offers a new approach to measuring organizational financial health based on the financial sustainability model. The objective in introducing these new financial indicators is to enable nonprofits to better manage their financial health and more confidently assure their ongoing financial sustainability. Usable measures of solvency, liquidity, and financial flexibility are introduced. Some of these measures are identical to those already in use, some are adapted from other ratios, and yet others are newly-developed. Actual data from a human services nonprofit organization are used to illustrate calculation of these measures. These measures are also placed in general, immediate-term, short-term, and medium-term classes, category scores calculated, and these category scores are combined into a numerical financial health index value (Φ). C-suite managers and board members may use this single index value to gauge their organization’s financial health relative to the next three years of operations. Managers may choose to remedy poor financial health by targeting improvement in individual measures or categories, and may choose to adopt written liquidity, debt, and investments policies consistent with those targets.
The metabolism of the 8-methyl ether of xanthurenic acid in the rabbit.

Abstract The metabolism of orally administered 8-methyl ether of xanthurenic acid-carboxy-14C and methoxy-14C was studied in rabbits. There was no evidence for decarboxylation of the 8-methyl ether of xanthurenic acid-carboxy-14C. However, rabbits O-demethylated nearly 20% of administered 8-methyl ether of xanthurenic acid-methoxy-14C, giving rise to 14CO2. This O-demethylation was accompanied by the presence of xanthurenic acid and its further metabolites, 8-hydroxyquinaldic acid and an 8-hydroxyquinaldic acid conjugate, in urine samples from rabbits receiving the 8-methyl ether of xanthurenic acid-carboxy-14C. The 8-methyl ether of xanthurenic acid-carboxy-14C and methoxy-14C were dehydroxylated in rabbits, as are xanthurenic acid and kynurenic acid, giving rise to a small amount of urinary 8-methoxyquinaldic acid. Thus, dehydroxylation represents a significant metabolic pathway for all 4-hydroxyquinoline-2-carboxylic acid derivatives studied to date. Pretreatment of rabbits with oral Neomycin sulfate in amounts sufficient to inhibit the multiplication of gastrointestinal microorganisms severely inhibited the O-demethylation and dehydroxylation of the 8-methyl ether of xanthurenic acid in rabbits. These results suggest that all further metabolism of the 8-methyl ether of xanthurenic acid in rabbits is mediated by or requires the presence of the gastrointestinal flora.
Marriage and Coming Out

Understanding of the process by which an individual with same sex sexual orientation becomes aware of his homosexuality and eventually embraces homosexual idetity is of great interest and importance to social work and the other helping professions. The coming out process appears to take place over an extended period of time and to have identifiable and predictable stages. This paper explored the process of coming out in a sample of 15 self-identified gay men who had been married to women. Four patterns of reasons for marriage in this group emerged, which we call: Repressed, Naive, Wistful and Pragmatic. Implications for social work practice are presented.
Blood pressure and survival in the oldest old

OBJECTIVES: To determine the relationship between blood pressure (BP) and all-cause mortality in subjects aged 80 and older with hypertension. DESIGN: Retrospective cohort study with 5 years of follow-up. SETTING: Ten Veterans AFFAIRS (VA) sites. PARTICIPANTS: Four thousand seventy-one ambulatory patients aged 80 and older with hypertension. MEASUREMENTS: The outcome measure was likelihood of survival during the follow-up period. Vital status was obtained from VA and Social Security files. Variables collected for adjustment in Cox regression models were baseline BP, medications, demographics, diagnoses, and health-related quality of life (HRQoL); HRQoL information was available on 1,289 subjects based on Veterans Health Study Short From-36 (SF-36) questionnaire scores. RESULTS: Subjects with higher BP (up to a systolic BP (SBP) of 139 mmHg and a diastolic BP (DBP) of 89 mmHg) were less likely to die during follow-up than subjects with lower BP. After baseline adjustments, the hazard ratio for a 10-point increase in SBP was 0.82 (95% confidence interval (CI)=0.74–0.91), up to a SBP of 139 mmHg, and for DBP was 0.85 (95% CI=0.78–0.92), up to a DBP of 89 mmHg. There was no significant association between survival and BP levels in subjects with uncontrolled hypertension. CONCLUSION: In a cohort of very old, hypertensive veterans, in subjects with controlled BPs, subjects with lower BP levels had a lower 5-year survival than those with higher BPs. This suggests that clinicians should use caution in their approach to BP lowering in this age group.
Fetal immune response following prematurely ruptured membranes.

Abstract Concentrations of immunoglobulins (Ig)A 1 , and IgA 2 , IgD, IgE, IgG, and IgM have been determined in cord blood, amniotic fluid, and maternal serum in a group of patients with a history of prematurely ruptured membranes (PRM) prior to the onset of labor and in a control group of patients undergoing normal delivery and without a history of infection during pregnancy. IgA and IgD were determined by sensitive hemagglutination-inhibition tests; IgG and IgM, by radial immunodiffusion; IgE, by a radiommunoassay. There was evidence for an immune response in 10 of 16 cases of PRM: five of 16 had increased IgA but normal IgM; three of 16 had increased IgA and IgM; two of 16 had high IgM and normal IgA in cord blood. In patients with significantly increased levels of either IgA or IgM or both, there was a decreased level of IgD. These changes are most likely the result of the immune response to ascending infection from the maternal genitals. The sensitive testing method employed could demonstrate the presence of IgD in 53 per cent of normal cord blood samples and 72 per cent of amniotic fluid samples obtained at term. IgE was found in all normal cord blood and amniotic fluid samples tested. By concentrating the amniotic fluid up to 180-fold, IgM was demonstrated in all normal samples tested. The potential importance of IgA determinations in cord blood in addition to IgM determination for detection of intrauterine infections is stressed.
E‐Cadherin enhances neuregulin signaling and promotes Schwann cell myelination

In myelinating Schwann cells, E-cadherin is a component of the adherens junctions that stabilize the architecture of the noncompact myelin region. In other cell types, E-cadherin has been considered as a signaling receptor that modulates intracellular signal transduction and cellular responses. To determine whether E-cadherin plays a regulatory role during Schwann cell myelination, we investigated the effects of E-cadherin deletion and over-expression in Schwann cells. In vivo, Schwann cell-specific E-cadherin ablation results in an early myelination delay. In Schwann cell-dorsal root ganglia neuron co-cultures, E-cadherin deletion attenuates myelin formation and shortens the myelin segment length. When over-expressed in Schwann cells, E-cadherin improves myelination on Nrg1 type III(+/-) neurons and induces myelination on normally non-myelinated axons of sympathetic neurons. The pro-myelinating effect of E-cadherin is associated with an enhanced Nrg1-erbB receptor signaling, including activation of the downstream Akt and Rac. Accordingly, in the absence of E-cadherin, Nrg1-signaling is diminished in Schwann cells. Our data also show that E-cadherin expression in Schwann cell is induced by axonal Nrg1 type III, indicating a reciprocal interaction between E-cadherin and the Nrg1 signaling. Altogether, our data suggest a regulatory function of E-cadherin that modulates Nrg1 signaling and promotes Schwann cell myelin formation.
NATURE OF THE ACTION CURRENT IN NITELLA : II. SPECIAL CASES.

The action curve involves four movements each of which shows considerable variation. These variations can be accounted for on the assumption that the action curve is due to the movement of potassium ions accompanied by an increase in permeability.
Assembly of multilayered films using well-defined, end-labeled poly(acrylic acid): influence of molecular weight on exponential growth in a synthetic weak polyelectrolyte system.

We report on the influence of polyanion molecular weight on the growth and structure of multilayered thin films fabricated from poly(allylamine) (PAH) and well-defined, end-labeled poly(acrylic acid) (PAA) synthesized by atom transfer radical polymerization. We observed striking differences in the growth of PAH/PAA films fabricated using well-defined PAA compared to films fabricated using higher molecular weight, commercially available PAA. Past studies demonstrate that the thicknesses of PAH/PAA films increase as linear functions of the number of PAH and PAA layers deposited over a broad range of pH (e.g., from pH 2.5 to 4.5). We observed the thicknesses of films fabricated using solutions of PAH and PAA adjusted to pH 7.5 and 3.5, respectively, to increase in a nonlinear manner. Films fabricated using well-defined, low molecular weight samples of PAA under these conditions increased in thickness exponentially. Experiments using samples of PAA having substantially non-overlapping molecular weight distrib...