Longer Length of Stay and No Chemotherapy Is Associated with Greater Likelihood of Death during Hospitalization in Patients with Diffuse Large B-Cell Lymphoma: An Analysis from the National Inpatient Sample (NIS)

Abstract Background: Patients with diffuse large B-cell lymphoma (DLBCL) are routinely treated in the outpatient setting. However, those who experience toxicity from a new diagnosis, relapsed disease, or outpatient chemotherapy may require inpatient admissions. Occasionally, patients with relapsed disease or a new diagnosis require inpatient chemotherapy. There is limited data on which patients are more likely to receive chemotherapy in the hospital, and which patients are more likely to suffer fatal complications during hospitalization. We examined patient and hospital characteristics associated with receiving inpatient chemotherapy and death during hospitalization for adults with DLBCL using a large US national database. Methods: We obtained admission data for patients with DLBCL from the 2012 and 2013 Agency for Healthcare Research and Quality's Healthcare Cost and Utilization Project National Inpatient Sample (HCUP-NIS). HCUP-NIS is a sampling of 20% of discharges from US hospitals, and provides weights that correspond to the total number of discharges represented by a single discharge in the dataset to provide national estimates. Utilizing existing variables in the HCUP-NIS database, including risk on the likelihood of dying, we performed univariate analysis of patient demographics associated with receipt of chemotherapy and death during hospitalization. We used multivariable logistic regression to identify predictors of death during hospitalization. The following factors were included: age, sex, income, insurance, number of chronic conditions, race, hospital type, region, length of stay (LOS), charges per day, and receipt of chemotherapy during the admission. All results apply the HCUP-NIS weights. Results: There were 10,860 admissions associated with DLBCL in 2012-2013. Median patient age was 70 years (IQR 59-78). Over half (55%) of admissions were of male patients. 3,170 (29%) of hospitalizations included administration of chemotherapy. Those who received chemotherapy in the hospital were younger (64 vs. 72 years, p 575 (5.3%) of hospitalizations resulted in death. Patients who died during hospitalization were older (median 74.6 vs. 69.4 years, p In multivariable regression, older age (OR 1.36 for 10-year increase, p=0.01) and longer LOS (OR 1.05, p Conclusions: The majority of hospitalizations for patients with DLBCL did not include administration of chemotherapy. Those who received inpatient chemotherapy were generally younger and male, had less comorbidity, were admitted to urban teaching hospitals, and did not have Medicare insurance. A minority of hospitalizations resulted in death. Longer LOS and no receipt of chemotherapy were predictive of death during admission. Our data suggest that the majority of inpatient stays for DLBCL were unplanned admissions due to toxicity, and socio-demographics were not significant factors compared to clinical acuity in identifying who was at risk for death. Download : Download high-res image (241KB) Download : Download full-size image Disclosures Kumar: Celgene: Membership on an entity's Board of Directors or advisory committees; Seattle Genetics: Research Funding.