cssi/SciSciGPT-SciSciNet huggingface dataset:
Promoting the Social and Cognitive Competence of Children with Autism: Interventions at School.

Addressing the needs of children with autism in the school context is an essential component of facilitating the success of these students. This article provides an overview of scientifically based and promising interventions that may be used to promote the social and cognitive competence of children with autism, focusing on the research base of these particular strategies. Brief descriptions and outcome data are provided for: a) Discrete Trial Training (DTT), b) Pivotal Response Treatment (PRT), c) Learning Experiences: An Alternative Program for Preschoolers and Parents (LEAP), d) The Picture Exchange Communication System (PECS), e) Incidental teaching, and f) The Treatment and Education of Autistic and Related Communication Handicapped Children (TEACCH). This article aims to bring science to practice through providing school psychologists and other educational professionals with a primer for selecting evidence-based approaches to address the needs of children with autism.
Cognitive Controls and Primary Processes

During this anniversary year, I have had the great pleasure of realizing a dream that had been with me throughout the 13 years since I left Harvard. At the Research Center for Mental Health in New York University, we have finally gotten under way a program of interrelated researches1 cast in a familiar mold: a sizable group of experimenters, some of them graduate students, some more elderly types like George Klein and myself, who are directing the work, all carrying out our personological researches on the same small group of subjects, who are intensively studied and assessed (see Murray et al., 1938). When someone invents a better general model for research in this area, I hope I shall not be so much blinded by sentiment and nostalgia as to be unable to adopt it; meanwhile, the old model seems to have plenty of power and mileage left in it.
EPIDEMIOLOGY OF INFLUENZA IN THE ELDERLY: EVIDENCE OF VIRUS RECYCLING

During the Hong Kong influenza epidemic of 1968-1969 the attack rate among persons born prior to 1890 was about one-third the rate among persons born after 1899. During an Asian influenza epidemic in the same community two years earlier there was no apparent age effect. Most persons born before 1890 had detectable pre-epidemic antibody against A/Hong Kong/68 whereas most persons born after 1899 had no detectable pre-epidemic antibody. The lower attack rate in the older age group is consistent with the hypothesis that influenza A viruses with similar or identical hemagglutinins can reemerge over time and that remote previous experience with the same or a similar strain can be protective. Also, no age group born after 1890 was found to have a high prevalence of antibody against A/England/72 or A/Dunedin/73, the successors to A/Hong Kong/68, indicating that recycling of hemagglutinin antigens is not strictly ordered.
Interplay between structure and transport properties of molten salt mixtures of ZnCl2–NaCl–KCl: A molecular dynamics study

Molten mixtures of network-forming covalently bonded ZnCl2 and network-modifying ionically bonded NaCl and KCl salts are investigated as high-temperature heat transfer fluids for concentrating solar power plants. Specifically, using molecular dynamics simulations, the interplay between the extent of the network structure, composition, and the transport properties (viscosity, thermal conductivity, and diffusion) of ZnCl2-NaCl-KCl molten salts is characterized. The Stokes-Einstein/Eyring relationship is found to break down in these network-forming liquids at high concentrations of ZnCl2 (>63 mol. %), while the Eyring relationship is seen with increasing KCl concentration. Further, the network modification due to the addition of K ions leads to formation of non-bridging terminal Cl ions, which in turn lead to a positive temperature dependence of thermal conductivity in these melts. This new understanding of transport in these ternary liquids enables the identification of appropriate concentrations of the network formers and network modifiers to design heat transfer fluids with desired transport properties for concentrating solar power plants.
Stresses in Ferroelectric Thin Films

The stresses in rf sputtered BaTiO 3 thin films, deposited on both Si and sapphire single crystals, were studied. From the measured total film stress values, both the intrinsic stresses in the film and the elastic coefficients [E f /(1– v f )] of the film were obtained. BaTiO 3 films can be obtained in any stress state (tensile, stress free or compressive) by varying the deposition temperature, deposition pressure, and substrate. At lower temperatures and pressures compressive intrinsic stresses were observed whereas, at high deposition temperatures and pressures intrinsic stresses were tensile in nature. The [E f /(1– v f )] value approached the single crystal value for films deposited at low pressures and decreased significantly with increasing deposition pressure.
Passive transfer of hypersensitivity to lepromin.

ConclusionsThese experiments indicate that the capacity to form a granulomatous response to lepromin can be induced in guinea pigs as a reaction of hypersensitivity directed toward M. leprae, and that this reactivity is transferable by viable lymphoid cells but not by heat-killed cells or by serum. On this basis, this responsiveness qualifies for inclusion in the category of the delayed hypersensitive states.
Working Class Self-Fashioning in Swing Time (1936)

This article argues that the Depression era musical, Swing Time (1936), provides access to understanding some of the forms of socially constructed desire that shaped working class solidarity in the 1930s. In the first part of this article, I explore the roots of Swing Time’s critique of vested forms of desire in Thorstein Veblen’s The Theory of the Leisure Class. I argue that Swing Time offers an extension of Veblen’s theory by analyzing the power of mass communication to rewire social circuits of desire. I then explore the meaning of the stylistic realism and the language of protest operating in Swing Time’s narrative. From this I conclude Swing Time offers a critique of capitalism precisely in order to affiliate itself with a new, working class oppositional culture. But in affiliating itself with this oppositional community, Swing Time accepts and reinforces the language of racial privilege circulating within the ‘white’ working class. With a final critical act, however, Swing Time symptomatically revea...
Teachingless Grinding Robot Depending on Three Force Informations

産業用ロボットが加工物の曲面を研削するとき, オペレータは研削面の形状を正確に教示しなければならない.しかしながら, この教示工程は, 教示点数が極めて多いために大変やっかいな作業である.本論文は, そのめんどうを除くために, ティーチングレス形のグラインディングロボットを提案している.このロボットシステムは, 手先に円柱状の砥石を取り付けたマニピュレータと, 3種類の力を測定する装置と, AD変換器をもつ計算機から構成されている.力情報の1つは, 研削トルクであり, 他の2つは, 砥石が加工物から受ける研削抵抗力の2成分である.砥石が加工物に接触する点の座標は, この3つの力情報から計算機で求められる.それゆえに, ロボットは加工物の曲面形状を認識することが出来て, ティーチングなしで加工物を研削することが出来る.5自由度の多関節型ロボットを用いて実験した結果, 提案したロボットシステムは加工物の連続的な曲面を研削できることがわかった.
Immunohistochemical evaluation of p16 expression in cutaneous histiocytic, fibrohistiocytic and undifferentiated lesions.

Background Expression of p16 is frequently evaluated in melanocytic lesions. Expression of p16 in cutaneous histiocytic, fibrohistiocytic and undifferentiated lesions has not been well characterized. Methods We evaluated p16 expression in a cohort of histiocytic (reticulohistiocytoma, Langerhans cell histiocytosis, xanthogranuloma, Rosai Dorfman disease and xanthoma), fibrohistiocytic (dermatofibroma, epithelioid fibrous histiocytoma and dermatofibrosarcoma protuberans) and undifferentiated (atypical fibroxanthoma and pleomorphic undifferentiated sarcoma) lesions. A group of melanocytic lesions (Spitz nevus, ordinary nevus, spitzoid melanoma and non-spitzoid melanoma) were also evaluated as reference. Each case was scored by the proportion of p16-positive cells and by staining intensity. Results Immunoreactivity for p16 was found in almost all histiocytic (28/30, 93%) and fibrohistiocytic (22/24, 92%) lesions. About half of the undifferentiated lesions also exhibited p16 staining (9/17, 53%). Most of the melanocytic cases examined in this study expressed p16. A wide range of staining intensity and proportion of p16-positive cells was observed in most groups. Conclusion Expression of p16 is common, albeit variable in proportion and intensity, amongst a wide variety of cutaneous histiocytic, fibrohistiocytic and undifferentiated lesions. Further studies are required to determine if p16 expression is useful in distinguishing benign from malignant neoplasms of these types.
Constructing an Open and Converged Service Platform with Cloud Computing

A unified business and development environment can be realized by using cloud computing technologies such as virtualization,distributed storage,and elastic scheduling.Constructing a next generation of service delivery platform can make the telecommunications more open and easy to integrate into businesses.Business development is made easier and there is a shorter development cycle and increased investment returns when open application programming interface (API) is used.Virtualization and resource scheduling will loosen the coupling between application and specific network environment and make business integration more convenient.
[Study on the superantigen gene profiles of group A Streptococcus isolated from children in Beijing, 2014].

Objective To investigate superantigen gene profiles of group A Streptococcus (GAS) isolated in Beijing pediatric patients in 2014, and to explore the the relationship between superantigen gene profiles with emm types, and GAS infections with diseases. Methods A total of 259 GAS strains were isolated from pediatric patients clinically who diagnosed with scarlet fever and pharyngitis from 36 hospitals in Beijing from May to July, 2014.The Superantigens genes of strains were performed by Real-time PCR (speA, speB, speC, speF, speG, speH, speI, speJ, speK, speL, speM, smeZ, ssa). PCR amplification of GAS strain M protein N gene segments were carried ort; products after sequencing comparison were analyzed to determine the GAS types of emm. The differences in distributions of superantigen genes and emm types of GAS isolates were compared between subgroups. Results Among the 259 GAS strains, the detection rates of 13 superantigens were as the following: speA 48.6% (126), speB 99.2% (257), speC 99.2% (257), speF 98.8% (256), speG 98.5% (255), speH 43.6% (113), speI 46.3% (120), speJ 49.0% (127), smeZ 99.2% (257) and ssa 98.5% (255), respectively, however, speK, speL, and speM were not found. Eleven superantigen gene profiles in all were observed (A-K). The percentage of emm1 strains harbored spe A and speJ were 94.2% (113/120), 95.0% (114/120), respectively, which were significantly higher than those of emm12 strains (5.6% (7/124), 5.6% (7/124),respectively; χ2=191.20,194.80,P 0.05). Conclusion The GSA strains isolated in Beijing pediatric patients in 2014, the relevance ratio of speB, speC, speF, smeZ, speG, ssa were higher than others, while speK, speL, and speM were no detected in any GAS strains. The superantigen genes appeared to be associated with the emm type. Furthermore, emm type distribution and superantigen genes were not different between scalet fever and pharyngitis. Key words: Streptococcus; Superantigens; Child; Emm typing
Autonome Regulation der zellulären Inflammation im septischen Ileus durch die Dünndarmmuskularis mittels Monocyte Chemoattractant Protein-1 (MCP-1)

Background: Endotoxemia causes a massive inflammation of the intestinal wall, which is associated with an inhibition of intestinal motility. The network of resident macrophages seems to play a major role as an initiator of this cascade. We hypothesize that these resident cells evoke the extravasation of immunocompetent leukocytes in the intestinal muscularis through the release of chemotactic cytokines (e.g. MCP-1). Methods: ACI rats were challenged with an intraperitoneal single bolus injection of lipopolysaccharide (LPS; 15 mg/kg). Observations were made over a 48 h period ( 1, 3, 6, 24, and 48 h). In a second experiment the animals were treated daily with an i.p. injection of LPS for 5 consecutive days. Cellular infiltration and MCP-1 protein expression was determined by immunohistochemistry. Semi-quantitative RT-PCR was used to measure MCP-1 mRNA expression. Spontaneous and bethanechol-stimulated circular muscle activity was assessed using a standard organ bath. Intestinal transit was measured at 24 h after LPS by evaluating the distribution of orally administered fluorescein-labeled dextran (at 90 min). Results: LPS application caused a delay in intestinal transit and a significant suppression of in vitro contractility. However, chronically injected animals showed an obvious improvement in smooth muscle activity. We observed a significant increase in leukocyte infiltration mostly attributed to extravasated monocytes. RT-PCR showed a significant increase in MCP-1 mRNA expression following LPS. LPS pretreatment resulted in a transcriptional adaption without any significant increase of the MCP-i expression. MCP-1 was immunohistochemically located in resident muscularis macrophages. Conclusions: Endotoxemia causes a distinct infiltration of leukocytes into the intestinal muscularis that was associated with a significant suppression of intestinal motility. The results suggest that locally derived MCP-1 represents a potential cause of the extravasation of immunocompetent cells. As an intestinal adaption in response to repeated LPS this mechanism disappears in chronically injected animals.
Peer counselling for the promotion of long-acting, reversible contraception among teens: a randomised, controlled trial.

AbstractAim: To evaluate the impact peer counselling has on same-day desire for long-acting, reversible contraception (LARC) among adolescents attending a family planning clinic.Methods: A randomised, controlled trial of 110 adolescent females attending an outpatient clinic for contraception in 2013. Adolescents received either brief peer counselling about LARC with routine contraceptive counselling, or routine counselling alone. Bivariate analyses and multivariable logistic regression assessed the primary outcome of same-day desire for LARC and secondary outcomes of change in knowledge and attitudes regarding LARC.Results: Peer counselling was well received and 70% reported that it was helpful in contraceptive decision-making. Peer counselling did not affect same-day desire for LARC, however, adolescents who received the intervention were more likely to report increased knowledge and positive change in attitudes towards LARC (adjusted odds ratios: 6.6 (95% confidence interval: 2.0–22.0 and 6.4 (1.6–26.8)...
The economic viability of gas-to-liquids technology and the crude oil–natural gas price relationship

Abstract This paper explores the viability of a gas-to-liquids (GTL) technology and examines how GTL penetration could shape the evolution of the crude oil–natural gas price ratio. Much research has established the cointegrated relationship between crude oil and natural gas prices in the U.S. The persistently low U.S. natural gas prices in recent years seem to mark a shift in this relationship, and have led some in industry to begin considering investments in GTL capacity in the US. In order to look forward over decades when the underlying economic drivers may be outside of historical experience, we use a computable general equilibrium model of the global economy to evaluate the economic viability of GTL and its impact on the evolution of the crude oil–natural gas price ratio. Our results are negative for the potential role of GTL. In order to produce any meaningful penetration of GTL, we find it necessary to evaluate scenarios that seem extreme. With any carbon cap GTL is not viable. Moreover, even without a carbon cap of any kind, extremely optimistic assumptions about (i) the cost and efficiency of GTL technology and about (ii) the available resource base of natural gas and the cost of extraction, before the technology penetrates and it impacts the evolution of the crude oil–natural gas price ratio.
Piecewise static policies for two-stage adjustable robust linear optimization

In this paper, we consider two-stage adjustable robust linear optimization problems under uncertain constraints and study the performance of piecewise static policies. These are a generalization of static policies where we divide the uncertainty set into several pieces and specify a static solution for each piece. We show that in the worst-case, there is no piecewise static policy with a polynomial number of pieces that has a significantly better performance than an optimal static policy. This is quite surprising as piecewise static policies are significantly more general than static policies. The proof is based on a combinatorial argument and the structure of piecewise static policies.
Abstract WP145: Intra-arterial Stem Cell Therapy for a Persistent Vegetative State Patient: A DTI Analysis of Recovery

Background: Cell therapy is promising in pre-clinical studies of global ischemia. The aim of this pilot study is to describe the first intra-arterial (IA) delivery of bone marrow derived ALD-401 ce...
Low temperature growth of CuO nanowires through direct oxidation

Abstract CuO nanowires (NWs) are important for various applications, thus finding a low cost synthesis route is vital to best utilize this material. Herein, CuO NWs synthesized by direct oxidation of pure copper foil in a dry air environment at a low temperature regime between 100 and 400 °C were studied. Based on the results of our research, we have unprecedentedly identified (1) the threshold temperature and oxidation duration required to form CuO NWs; (2) an opposite trend in the NW lengths as function of temperature below 400 °C compared to that of above 400 °C; and (3) unambiguous evidences on the formation of Cu 2 O layer prior to the CuO NW formation. In particular, the threshold temperature and oxidation duration required to form CuO NWs are determined to be 250 °C and 2 h, respectively. The lengths and widths of the synthesized CuO NWs were found to be controllable with temperature (300 and 400 °C) and oxidation duration (1–3 h) ranging from 0.78 to 2.91 μ m and 20 to 90 nm, respectively. The trend of the NW lengths was found to be increasing as the temperature increases and below 400 °C, which is opposite to that for oxidation temperature higher than 400 °C. Based on a combination of the Raman, X-ray diffraction, and scanning electron microscopy measurements, it was further concluded that a Cu 2 O layer is formed right before CuO NW growth.
Economic Competition, Policy Interdependence, and Labour Rights

Extant scholarship treats national policies concerning labour rights as a function of economic factors and yet neglects influences of policies among economically competing states. Relying on the po...
MR Imaging of Prostate Zonal Anatomy

McNeal first described the zonal anatomy of the prostate about 40 years ago, outlining 4 zones of the prostate and defining their relation to the urethra and the ejaculatory ducts. The zonal anatomy remains the accepted model for describing the prostate and the zones are well-depicted on MR imaging, including the central zone, which until recently was grouped with the transition zone in the radiology literature. An accurate understanding of the zonal anatomy and periprostatic anatomy is key for accurate interpretation of the prostate MR imaging.
Hearing Aid Acquisition in Chinese Older Adults With Hearing Loss

Objectives. To investigate the prevalence and associated factors of hearing aid acquisition in Chinese older adults.Methods. We obtained data from a population-based survey on ear and hearing disorders, which was conducted in 4 provinces of China in 2014 to 2015. Trained examiners conducted pure tone audiometry and audiologists further ascertained for hearing loss. We relied on hearing conditions and audiologists’ recommendations to identify 1503 participants who needed to wear hearing aids.Results. Among those 1503 participants, the estimated prevalence of hearing aid acquisition was 6.5% (95% confidence interval = 5.3%, 7.8%). Urban residency, having severe hearing loss, understanding hearing aid function, and receiving a hearing test in the past 12 months were associated with elevated prevalence of hearing aid acquisition. The top-3 reported reasons for not acquiring a hearing aid were not understanding its function (25.4%), not needing it (22.3%), and not being able to afford it (21.3%).Conclusions. H...
The Cassini/Huygens Navigation Ground Data System: Design, Implementation, and Operations

The highly successful Cassini/Huygens mission conducted almost 20 years of scientific research in both its journey across the solar system and its 13-year reconnaissance of the Saturnian system. This operational effort was orchestrated by the Cassini/Huygens Spacecraft Navigation team on a network of computer systems that met a requirement for no more than two minutes of unplanned downtime a year (99.9995% availability). The work of spacecraft navigation involved rigorous requirements for accuracy and completeness carried out often under uncompromising critical time pressures and resulted from a complex interplay between several teams within the Cassini Project, conducted on the Ground Data System. To support the Navigation function, a fault-tolerant, secure, high-reliability/high-availability computational environment was necessary to support operations data processing. This paper discusses the design, implementation, re-implementation, and operation of the Navigation Ground Data System. Systems analysis and performance tuning based on a review of science goals and user consultation informed the initial launch and cruise configuration requirements, and then those requirements were subsequently upgraded for support of the demanding orbital tour of the Saturn System. Configuration management was integrated with fault-tolerant design and security engineering, according to cornerstone principles of Confidentiality, Integrity, and Availability, and strategic design approaches such as Defense in Depth, Least Privilege, and Vulnerability Removal. Included with this approach were security benchmarks and validation to meet strict confidence levels. The implementation of this computational environment incorporated a secure, modular system that met its reliability metrics and experienced almost no downtime throughout tour operations.
Existence of Pure and Behavior Strategy Stationary Markov Equilibrium in Dynamic Stochastic Games

This paper demonstrates the existence of pure strategy stationary Markov equilibrium in a class of dynamic stochastic games. Our main result implies the existence of behavior strategy stationary Markov equilibrium in any stochastic games in which the sets of actions are compact, the set of states is countable, the period payoff function to a player depends U.S.C.-L.S.C. on actions, and the transition function depends continuously on the actions. Additionally, if for each player a static best reply set is convex, then the equilibrium can be taken to be a pure strategy equilibrium. Our method of proof is simple and highlights the similarities between the static and the dynamic models. Several applications and corollaries are presented.
37. Association of levels of antepartum angiogenic factors with severe postpartum hypertension

Introduction Postpartum hypertension (PPHTN) often arises from an existing hypertensive disorder of pregnancy (HDP). Limited data exists about antecedent presentation and risk factors of PPHTN, especially among high risk groups such as African American (AA) women. We studied the association between levels of antepartum angiogenic biomarkers (soluble fms-like tyrosine kinase-1 [sFlt1] and placental growth factor [PlGF]) and risk of severe PPHTN among predominantly AA women. Methods Women with HDP were enrolled upon admission and blood was collected within 96 h of delivery. sFlt1 and PlGF were measured on an automated platform. PPHTN was defined as severe if systolic blood pressures (SBP) was ⩾160 or diastolic blood pressure (DBP) ⩾110 and mild if SBP ⩾140 or DBP ⩾90. Descriptive statistics are reported and assessed with a Wilcoxon Rank Sum or chi-square test, as appropriate. Univariate and multivariable logistic regression was used to assess the association between PPHTN and angiogenic factors, reporting the area under the receiver operating curve (AUC). Results A total of 375 women were enrolled, with 279 (74.4%) AA and 151 (40.3%) who met criteria for severe PPHTN. About half (52.9%) of women with severe PPHTN also had pre-eclampsia with severe features prior to delivery. The sFlt1/PlGF ratio was significantly higher for both severe and mild PPHTN compared to women with normal postpartum BPs (73.5, 46.0 and 13.0 respectively, p-values Conclusion Severe PPHTN is frequent in women presenting with antepartum HDP in this patient population. There is a significant association between antepartum angiogenic biomarkers and severe PPHTN. Further studies need to evaluate the mechanisms of such association.
EFunBlocks: A Component Based Function Block Intepreter for the Microchip PIC24F Family

EFunBlocks is a complete standalone component based function block kernel implemented for the PIC24FV32KA302 microcontroller to facilitate the development of rapidly prototyped embedded applications for Computer Organization Computer Science Education course at Clayton State University. The implementation is specifically designed to be available to diverse student owned devices using limited software on the students device.
Data-driven proximal algorithms for the design of structured optimal feedback gains

Distributed feedback design and complexity constrained control are examples of problems posed within the domain of structured optimal feedback synthesis. The optimal feedback gain is typically a non-convex function of system primitives. However, in recent years, algorithms have been proposed to obtain locally optimal solutions. In applications to large-scale distributed control, the major obstacle is computational complexity. This paper addresses complexity through a combination of linear-algebraic techniques and computational methods adapted from both machine learning and reinforcement learning. It is shown that for general classes of optimal control problems, the objective function and its gradient can be computed from data. Transformations borrowed from the theory of reinforcement learning are adapted to obtain simulation-based algorithms for computing the structured optimal $H_{2}$ feedback gain. Customized proximal algorithms based on gradient descent and incremental gradient are tested in computational experiments and their relative merits are discussed.
Male breast cancer: are there racial disparities in incidence and tumor characteristics?

Background: Racial disparities in female breast cancer (BC) outcomes have been well documented; however, less is known about patterns of BC and outcome disparities in men.Methods: Data (1973 to 2012) from the Surveillance, Epidemiology, and End Results Program database were used to compare BC patterns among Non-Hispanic Black (NHB) and Non-Hispanic White (NHW) men and women. Differences in tumor characteristics analyzed included estrogen receptor (ER), progesterone receptor (PR) status, stage and grade.Results: BC incidence was 1.00 per 100,000 for men and 116.21 for females. Among men, the BC incidence was 51% higher for NHB compared to NHW (rate ratio = 1.51, 95% CI: 1.42 – 1.61). Men were diagnosed an average of 5 years later than women; however NHB men (average age at diagnosis 63 years) overall were diagnosed 4 years earlier than NHW men (average age at diagnosis 67 years). NHB men showed a higher proportion of ER negative tumors compared to NHW men. As compared to NHW men, the odds of NHB men developing ER- BC was 1.67 (95% CI [1.21 – 2.31]) and 1.84 for ERPR- (95% CI [1.28 – 2.67]).Conclusion: As observed among NHB women, NHB men are more likely to be diagnosed with more advanced disease features and also experience a higher proportion of hormone negative BC compared to NHW men.
Regional Anesthesia Techniques for Abdominal Operations

The aim of this chapter is to challenge and encourage anesthesiologists and surgeons to consider adding existing or newer regional anesthesia techniques to their repertoire to minimize postoperative pain following abdominal operations. Use of regional anesthesia techniques is an important and increasingly widely used component of multimodal analgesia. Effective blocks result in reduced use of systemic oral and intravenous analgesics, especially opioids, and allow earlier return to normal function.
[COVID-19 in nursing homes A study of diagnosis, symptomatology and disease course]

Objective To describe the diagnosis, symptomatology and disease course of COVID-19 in nursing home (NH) residents in the Netherlands. Design Prospective cohort study. Method Data on NH residents with suspected COVID-19 were collected from the electronic patient records. Data were collected on diagnostic status (COVID-19: confirmed/excluded (using the RT-PCR test)), symptomatology (typical/atypical and other symptoms, body temperature and oxygen saturation) and, in the case of confirmed COVID-19, on disease course (recovered/clinically improved/deteriorated, deceased). We described and compared the symptomatology in NH residents with confirmed COVID-19 and NH residents in whom COVID-19 had been excluded. We also analysed mortality risk using survival analysis. We used registrations from the period 18 March to15 April 2020 for this study. Results We reported on 1,969 NH residents with suspected COVID-19. The diagnosis was confirmed in 857 patients (43.5%); diagnosis was excluded in 1,112 (56.5%) patients. Among patients with confirmed COVID-19, 65% had coughs, 70% had fever, 33% had shortness of breath, 28% had delirium/confusion and 10% had a sore throat; in patients in whom COVID-19 was excluded these symptoms were experienced in 70%, 47%, 45%, 26% and 13% of patients, respectively. Of the patients with confirmed COVID-19, 48% died within 30 days (95% CI: 36-44%), versus 20% of the patients in whom COVID-19 was excluded (95% CI: 11-15%). Conclusion There is a lot of overlap in symptomatology between NH residents with COVID-19 and those with other acute diseases. An RT-PCR test is required to be able to make the distinction better. The mortality risk in patients with confirmed COVID-19 is significantly higher than in patients in whom covid-19 is excluded.
Direct Ink Writing of Metal Oxide/H-ZSM-5 Catalysts for N-Hexane Cracking: A New Method of Additive Manufacturing with High Metal Oxide Loading

Previously, 3D printing of porous materials and metal oxides was limited to low loading metal loadings, as increasing the nitrate salt concentrations, which are used to generate the oxide component, gave rise to poor rheological properties beyond 10 wt %. In this study, we addressed this problem by directly printing insoluble oxides alongside H-ZSM-5 zeolite, which allowed for increased oxide loadings. Various metal oxides such as V2O5, ZrO2, Cr2O3, and Ga2O3 were doped onto H-ZSM-5 through the additive manufacturing method. Characterization and correlation between the X-ray diffraction, NH3-temperature-programmed desorption, O2-temperature programmed oxidation, temperature-programmed reduction, scanning electron microscopy-energy dispersive spectroscopy, and in situ CO2 DRIFTS experiments revealed that directly 3D printing metal oxides/H-ZSM-5 inks leads to significant modification in the surface properties and oxide bulk dispersion, thereby enhancing the composites' reducibility and giving rise to widely differing product distributions in n-hexane cracking reaction. The obtained metal oxide/zeolite structured materials were used as bifunctional structured catalysts for the selective formation of light olefins from hexane at 550-600 °C and GHSV = 9000 mL/gcatalst·h in a packed-bed reactor. Among the various compositions of metal oxides/H-ZSM-5 examined (i.e., 15 wt % Ga2O3, 15 wt % ZrO2, 15 wt % V2O5, 15 wt % Cr2O3, or 5 wt % Cr/10 wt % ZrO2/10 wt % V2O5/10 wt % Ga2O3 balanced with H-ZSM-5), the 15 wt % Cr/ZSM-5 monolith displayed the best n-hexane cracking performance, as it achieved 80-85% conversion of hexane with a 40% selectivity toward propylene, 30% selectivity toward ethylene, and 10% selectivity toward butene at 550 °C. The sample also showed zero benzene/toluene/xylene selectivity and no deactivation after 6 h. This study represents a proof-of-concept for tailoring customizable heterogeneous structured catalysts by directly 3D printing high loading of metal oxides/porous zeolite and is a breakthrough in material science.
Intraoperative spectrally encoded coherence tomography and reflectometry (iSECTR) for ophthalmic surgical guidance

Intraoperative optical coherence tomography (iOCT) has enabled depth-resolved intraoperative imaging of retinal microstructures. Despite recent advancements, iOCT of surgical maneuvers remains challenging because the imaging field-of-view requires manual adjustment and tracking. To overcome this limitation, we previously demonstrated spectrally encoded coherence tomography and reflectometry (SECTR), which provides OCT imaging and a complementary en face view for visualization of surgical instruments and tool-tracking. Here, we demonstrate ophthalmic imaging with an intraoperative SECTR (iSECTR) system integrated with a surgical microscope. We believe that iSECTR will allow for real-time feedback on the location and depth of surgical instruments to better guide ophthalmic surgery.
Hyperinsulinemic Compensation for Insulin Resistance Occurs Independent of Elevated Glycemia in Male Dogs.

Insulin resistance engenders a compensatory increase in plasma insulin. Inadequate compensation is a primary element in the pathogenesis of type 2 diabetes. The signal that heralds developing insulin resistance and initiates hyperinsulinemic compensation is not known. It has often been assumed to be increased glucose. We tested this assumption by determining whether development of fasting and/or glucose-stimulated hyperinsulinemia with diet-induced insulin resistance occurs because of concomitant elevation of glycemia. Male dogs (n = 58) were fed a hypercaloric, fat-supplemented diet for 6 weeks. Dogs underwent magnetic resonance imaging to quantify total and regional (visceral, subcutaneous) adiposity as well as euglycemic hyperinsulinemic clamps. A subset of animals also underwent an insulin-modified intravenous glucose tolerance test to assess insulin sensitivity, acute insulin response (AIRg), and glucose effectiveness. Fat feeding caused modest weight gain, increased visceral and subcutaneous fat, and insulin resistance at both peripheral and hepatic levels. Hyperinsulinemic compensation was observed in fasting levels as well as increased AIRg. However, we observed absolutely no increase in carefully measured fasting, evening (6 to 8 pm) or nocturnal glycemia (2 to 4 am). Insulin resistance and hyperinsulinemia occurred despite no elevation in 24-hour glucose. Compensatory development of hyperinsulinemia during diet-induced insulin resistance occurs without elevated fasting or 24-hour glycemia. These data refute the idea that glucose itself is a requisite signal for β-cell upregulation. Alternative feedback mechanisms need to be identified.
Biochemical genesis of enzymatic and non-enzymatic post-translational modifications.

Abstract Post-translational modifications (PTMs) alter protein structure, function, and localization and play a pivotal role in physiological and pathophysiological conditions. Many PTMs arise from endogenous metabolic intermediates and serve as sensors for metabolic feedback to maintain cell growth and homeostasis. A key feature to PTMs is their biochemical genesis, which can result from either non-enzymatic adduction (nPTMs) or through enzyme-catalyzed reactions (ePTMs). The abundance and site-specificity of PTMs are determined by dedicated classes of enzymes that add (writers) or remove (erasers) the chemical addition. In this review we will highlight the biochemical genesis and regulation of a few of the 700+ PTMs that have been identified.
Satira social y los antiguos dioses mexicanos en la narrativa de fuentes

Traduccion de Angelika M. Scherp. Carlos Fuentes ofrece una critica penetrante dei caracter nacional mexicano en sus novelas, cuentos y ensayos; sujeta a la satira cortante todas las normas sociales, instituciones politicas y debilidades personales en el Mexico del siglo XX. Fuentes ataca el esnobismo de los residuos de la aristocracia porfiriana y las pretensiones y avaricia de los nouveaux riches. Latiguea la decadencia y la hipocresia de los intelectuales que proclaman simpatia con la plebe mientras que en realidad apoyan al “grupo cosmopolita” seudo-sofisticado y„ como ellos, freneticamente buscan posicion social y riqueza.
Dynamic-Agents, Workflow and XML for E-Commerce Automation

Agent technologies are now being considered for automating tasks in e-commerce applications. However, conventional software agents with predefined functions, but without the ability to modify behavior dynamically, may be too limited for mediating E-Commerce applications properly, since they cannot switch roles or adjust their behavior to participate in dynamically formed partnerships. We have developed a Java-based dynamic agent infrastructure for E-Commerce automation, which supports dynamic behavior modification of agents, a significant difference from other agent platforms. Supported by dynamic agents, mechanisms have been developed for plugging in workflow and multi-agent cooperation, and for dynamic service provisioning, allowing services to be constructed on the fly. We treat an agent as a Web object with an associated URL, which makes it possible to monitor and interact with the agent remotely via any Web browser. XML is chosen as our agent communication message format. Dynamic agents can carry, switch and exchange domain-specific XML interpreters. In this way, the cooperation of dynamic agents supports plug-and-play commerce, mediating businesses that are built on one another's services. A prototype has been deve loped at HP Labs.
The GAZER Theorem Prover

We describe GAZER theorem proving system which was designed as a testbed for developing ideas about choosing which definitions and lemmas to use in the search for a proof. GAZER is a sequent calculus based system for first-order logic. The main novelty is the use of a new inference rule, gazing, which enables the system to determine which of a possibly large number of definitions and lemmas to use at any point in the proof. This decision is made on the basis of multiple abstractions of the current conjecture and of the database of definitions and lemmas. We have used gazer to prove theorems from naive set theory, and a detailed comparison of the success of the gazing inference rule in cutting down the search for proofs of these theorems is presented in [BP89b].
Classification of threats via a multi-sensor security portal

Classification of threats has always been a major security decision issue when a person walks through a security portal. To classify threat by combining data from multiple sensors like Millimeter Wave (MMW) imagery and Multi-zone Metal Detector is proposed and studied. Decisions made according to data from multiple sensors are analyzed. We present results for processing the fused sensor data and study the performance of several learning algorithms on this task. Usually the decision is being made based on single types of sensors, e.g., pulse induction metal detectors. We wish to identify the threats which are not determined by metal detectors alone.
A photocathode RF gun design for a mm-wave linac-based FEL

In recent years, advances in the RF gun technology have made it possible to produce small beam emittances suitable for short period microundulators which take advantage of the low emittance beam to reduce the wavelength of free-electron lasers (FELs). At the Advanced Photon Source, we are studying the design of a compact 50-MeV superconducting mm-wave linac-based FEL for the production of short wavelengths (/spl sim/300 nm) to carry out FEL demonstration experiments. The electron source considered for the linac is a 30-GHz, 3 1/2 -cell /spl pi/-mode photocathode RF gun. For cold model RF measurements a 15-GHz prototype structure was fabricated. Here we report on the design, numerical modeling and the initial cold-model RF measurement results on the 15-GHz prototype structure.
Quantitative phosphoproteomics reveals novel Vav1-dependent pathways in T cell receptor signaling (IRM10P.736)

Vav1, a Rac/Rho guanine nucleotide exchange factor, is a critical component of the T cell receptor (TCR) signaling cascade and is rapidly tyrosine phosphorylated in response to T cell activation. Previous studies using Vav1 knockout models have determined its importance in TCR-dependent signaling. However, a wide-scale characterization of Vav1-dependent phosphorylation events is still lacking. Using quantitative mass spectrometry, a phosphoproteomic analysis of 668 tyrosine phosphorylation sites was performed on Vav1-deficient T cells across four time points of TCR stimulation. Compared to controls, cells lacking Vav1 expression showed statistically significant decreases in phosphorylation on actin cytoskeletal signaling proteins, supporting the role of Vav1 in cytoskeletal reorganization. Interestingly, loss of Vav1 led to perturbations in phosphorylation on signaling molecules proximal to the TCR. Furthermore, proteins implicated in negative feedback pathways, including CBL and PAG, showed altered phosphorylation profiles. Effects further downstream of the TCR were also observed in Vav1-deficient cells, notably, hyperphosphorylation of inhibitory sites on various cyclin dependent kinases, suggesting cell cycle arrest. This data demonstrates novel signaling networks regulated by Vav1 and support the pleiotropic functions of Vav1 downstream of the TCR.
Profile of serum estriol and its conjugates at delivery and in the immediate postpartum period in a patient with severe polycystic kidney disease: A comparison with normal pregnancy

A patient with group C polycystic kidney disease had abnormally high concentrations of total serum estriol (E3) but low-normal urinary levels of E3 throughout the period of study (20 weeks of gestation until delivery by cesarean section at 33 weeks, 5 days). At delivery and at regular intervals until 6 hours thereafter serum specimens were analyzed for unconjugated E3 and its four major conjugates. Comparisons were made with levels in three normal volunteer subjects studied in the same way. In the 6 hours, total E3 declined 37% in the subject with polycystic kidney disease whereas in normal subjects the decline ranged from 84% to 99%. Unconjugated E3 was depleted from the serum in all subjects in about 2 hours. The major difference between the patient with polycystic kidney disease and the normal subjects was in the profile of E3 conjugates. In polycystic kidney disease, E3-3-glucosiduronate (E3-3G) and E3-3-sulfate-16-glucosiduronate (E3-SG) respectively made up 83% and 1.8% of the total serum estriol, whereas in the normal subjects the average values were 13% for E3-3G and 49% for E3-SG. There were no consistent dramatic changes in the percentage contribution of any conjugate to the total E3 level in either the patient with polycystic kidney disease or the normal subjects in the predelivery or postdelivery periods. The E3 profile in polycystic kidney disease is explainable in terms of impaired renal function coupled with normal enterohepatic metabolism of E3.
Dinuclear Organometallic Cluster Complexes

Metal–metal bonding in dinuclear complexes plays a key role in inorganic and organometallic chemistry. It is the basis for development of polymers and clusters derived from this simple unit. Its chemistry now approaches the ‘functional group’ status, typically used in organic chemistry for classes of compounds. However, owing to the array of metals and oxidation states involved, a wide range of structures, reactions, and properties are observed for this important class of compounds. This article introduces the topic of metal–metal bonded complexes and attempts to outline the synthetic strategies used to prepare metal–metal bonded complexes, some of their characteristic properties and reactions, as well as to provide a brief introduction to historical development and emerging directions of this central area of inorganic chemistry. Keywords: metal–metal bonding; metals; dimeric; clusters; catalysis; bond strengths; dinuclear; heteronuclear; homonuclear
Mechanism of Cannabinoid Effects on Long-Term Potentiation and Depression in Hippocampal CA1 Neurons

Cannabinoids, the active constituents of marijuana, are known to impair learning and memory. Receptors for cannabinoids are highly expressed in the hippocampus, a brain region that is believed to play an important role in certain forms of learning and memory. To investigate the possible contribution of cannabinoid receptor-mediated deficits in hippocampal function to the learning and memory impairments produced by marijuana, we studied the effects of cannabinoid receptor activation on two models of learning and memory, long-term potentiation (LTP) and long-term depression (LTD), in hippocampal slices. Although LTP and LTD of CA1 field potentials were blocked by cannabinoid receptor activation in the presence of Mg(2+), they could be induced after Mg(2+) was removed. Similarly, LTP and LTD of whole-cell EPSCs were unimpaired in the presence of cannabinoid receptor agonist when the postsynaptic membrane was depolarized during the LTP or LTD induction protocol. Cannabinoid receptor activation also reduced EPSCs and enhanced paired-pulse facilitation, while having no effect on the amplitude of spontaneous miniature EPSCs. Finally, as with cannabinoid receptor activation, inhibition of LTP by adenosine receptor activation could be overcome by removal of Mg(2+) or depolarization of the postsynaptic membrane during tetanus. Our results indicate that cannabinoid receptor activation does not directly inhibit the molecular mechanisms responsible for long-term synaptic plasticity but instead impairs LTP and LTD by reducing presynaptic neurotransmitter release to a level below that required to depolarize the postsynaptic membrane to relieve Mg(2+) blockade of NMDA receptors.
Summary of the first 100 patients seen at a Lyme disease referral center.

Abstract purpose and patients and methods: Lyme disease is a major clinical problem in a number of endemic areas in the United States. In areas where anxiety about the disease is high, patients and physicians often ascribe clinical concerns to Lyme disease. Incorrect diagnosis often leads to unnecessary antibiotic treatment (often prolonged or repeated intravenous therapy). This report summarizes the cases of the first 100 patients referred to the Lyme Disease Center at Robert Wood Johnson Medical School. results: In only 37 of the patients referred was Lyme disease, either current or preceding, the explanation for the complaints. Many of the patients had another definable arthropathy. Twenty-five of the patients had fibromyalgia, which has not previously been reported in Lyme disease. Three of these patients had active Lyme disease at the time of evaluation, and 17 had a history suggesting preceding Lyme disease. Approximately half of the 91 courses of antibiotic therapy given to these 100 patients before referral were probably unwarranted. conclusions: Anxiety about possible late manifestations of Lyme disease has made Lyme disease a "diagnosis of exclusion" in many endemic areas. Persistence of mild to moderate symptoms after adequate therapy and misdiagnosis of fibromyalgia and fatigue may incorrectly suggest persistence of infection, leading to further antibiotic therapy. Attention to patient anxiety and increased awareness of these musculoskeletal problems after therapy should decrease unnecessary therapy of previously treated Lyme disease.