cssi/SciSciGPT-SciSciNet huggingface dataset:
A Pseudo-outbreak of Streptomyces Infections Linked to Laboratory Construction

Over a four-week period, nine isolates of Streptomyces species were identified from seven blood cultures, one infected gortex graft, and one cerebrospinal fluid (CSF) specimen. None of the patients were clinically infected or received antimicrobial therapy. Blood culture collecting tubes, iodoform prep solutions, BAC-TEC® filters, and alcohol prep pads were cultured but did not reveal a source of contamination. Six additional clinical specimens became positive, and the occurrence of construction in the laboratory was considered as a source of the contaminating organism. Blood agar plates were placed for 20 minutes in an area undergoing construction. Streptomyces grew in heavy concentrations on nine of ten plates in the construction site, but only one colony on ten plates grew from a hallway not undergoing construction. Isolation of the organism ceased with cessation of the construction. The authors conclude that the Streptomyces pseudo-outbreak was related to construction around the laboratory, with probable airborne contamination of clinical specimens.
Design of Resistive Current Tester Calibration Device for Zinc Oxide Arrester

Based on the standard DLT 987—2005,technology indexes of zinc oxide arrester resistive current tester calibration were proposed. The hardware circuit design method of bridge driver and Howland constant-current source was given,and the attentions should be paid to the design were pointed out. The precision and stability of output signal could meet the requirement based on the experimental data.
Ridge patterns of blood-transferred simulated fingerprints observed on fabrics via steam thermography

Abstract Steam thermography is used to image ridge patterns of blood-transferred artificial fingerprints on acrylic, polyester and cotton fabrics. Microscale thermal imaging confirms that the ridge patter transfer occurs on the tops of the most prominent threads in weave. Prints are readily imaged on the more hydrophobic fabrics in both heat-up and cool-down phases of vapor exposure. On the more hydrophilic cotton fabric, ridge detail is obscured by the strong background response of the fabric to moisture. Microscale thermography reveals that loose cotton strands with transferred blood may respond differentially to moisture relative to uncoated strands.
INITIATION AND GROWTH-TO-DETONATION IN REACTIVE MIXTURES

It is generally accepted that, for given loading conditions, the details of the microstructural processes determine the initiation and growth-to-detonation in porous and granular explosive mixtures. This view has led to the development of several different models of such phenomena. This paper will focus on a recently developed approach based on the theory of multiphase mixtures. The theory provides a thermodynamic structure in which to describe the response of the individual phases of the mixture and how they interact. Each phase may have its own equation of state and specific micromechanical models for pore collapse, local viscous effects, local heat transfer, and grain burning are used to describe the phase interactions. Applications of the theory to shock initiation of PBX-9404 and deflagration-to-detonation transition in CP are presented.
Abstract 4653: Combination Azacitidine and histone deacetylase inhibition induces a multi factorial synergistic anti-tumor response in non-small cell lung cancer (NSCLC)

Proceedings: AACR 107th Annual Meeting 2016; April 16-20, 2016; New Orleans, LA Epigenetic therapy holds much promise as an emerging paradigm for the treatment of many disparate types of human cancer. However, the data in solid malignancies, particularly, would suggest further optimization is required to extract the true potential of these therapies. In our current study, we have deployed at low, clinically achievable doses, chronic combinatorial administration of the DNA methyltransferase inhibitor Azacitidine in conjunction with both benzamide and hydroxyamic acid based histone deacetylase inhibitors (HDACi) in NSCLC. We have developed our paradigms by sequentially employing chronic HDACi administration after Azacitidine. This strategy achieves durable alteration of the cell transcriptome with corresponding induction of both cell cycle arrest and apoptosis. These events appear driven by alterations, both transcriptionally and post transcriptionally of Myc and Myc regulatory proteins. Epigenetic treatment induced perturbation of Myc is facilitated by Wnt pathway inhibition through induction of Wnt antagonists, namely DKK proteins. Importantly, as part of this scenario of altering a Myc regulatory axis, there is a synergistic cytotoxic response mediated at least in part through downregulation of a critical effector, the Skp2 oncogene. Additionally, we observe significant induction of an interferon responsive viral defense gene signature as the result of epigenetic treatment. This gene signature has been shown to correlate with response to immune checkpoint blockade in the setting of metastatic melanoma. We propose that this combination of viral defense gene signature augmentation in conjunction with potent direct epithelial cancer cytotoxicity holds promise to be a more complete therapeutic paradigm for the treatment of NSCLC. Citation Format: Michael Topper, Christin Hanigan, Michelle Vaz, Katherine Chiappinelli, Julin Justin, Lauren Murphy, Cynthia Zahnow, Stephen Baylin. Combination Azacitidine and histone deacetylase inhibition induces a multi factorial synergistic anti-tumor response in non-small cell lung cancer (NSCLC). [abstract]. In: Proceedings of the 107th Annual Meeting of the American Association for Cancer Research; 2016 Apr 16-20; New Orleans, LA. Philadelphia (PA): AACR; Cancer Res 2016;76(14 Suppl):Abstract nr 4653.
AN ANALYSIS OF CONCEPTS FROM THE POINT OF VIEW OF THE STRUCTURE OF INTELLECT

Publisher Summary This chapter presents an analysis of concepts from the point of view of the structure of intellect. It presents a rather formal presentation of the three categories, namely, thinking operation (process), content (material), and outcome (product)—and the 15 primitive notions involved within these categories in the model. The possibility of describing learning in terms of the structure-of-intellect model is properly restricted to the description of individual differences among learners. Laws of Learning may be, at present, partially obscured by individual differences in the learners. Even the simplest forms of learning may be, in terms of the mental functions, rather complex. It seems unlikely that random assignment to groups or even simple covariance designs will provide the greater control and sensitivity required for further exploration of learning. Utilization of measures from the structure-of-intellect model should help to clarify and delimit the generality of laws of learning appropriate to the complex human organism.
The Sport Education Model: A Track and Field Unit Application

Track and field is a traditional instructional unit often taught in secondary physical education settings due to its history, variety of events, and potential for student interest. This article provides an approach to teaching this unit using the sport education model (SEM) of instruction, which has traditionally been presented as a model for team and dual sports. The application of the SEM to this individual sport provides teachers with an opportunity to provide their students with an authentic, engaging and festive environment in which to learn a sport that has been around for centuries.
A new paradigm in CLL: Minimizing toxicity by using the minimum effective dose (MED) of lenalidomide for older patients with CLL.

6609 Background: While CIT has proven active for younger patients with CLL; studies from Germany and MDACC with fludarabine or fludarabine- based regimens did not benefit the patient over the age o...
Using Mentoring, Coaching, and Self-Mentoring to Support Public School Educators

ABSTRACTAssimilating new teachers into schools is a critical component of administrative responsibility and sustainability. About 580 000 teachers (17% of all teachers) were newly hired at their school, according to the US Department of Education. Most of these positions were created because of “teacher turnover.” Some of these newly hired teachers filled new teaching positions in the workforce as well—which grew by three percent over the previous two years. As this number rises, there is a concentrated effort by building administrators to provide support and resources for beginning teachers to help eliminate teacher turnover and strengthen staffing at schools. Support for new teachers varies from district to district and even from school to school. Traditional induction programs offer mentoring and coaching methods. More recently, the concept of self-mentoring emerged. The purpose of this paper is to introduce the concept of self-mentoring as a tool for beginning teachers.
Optical Functions of Thin-Film Polycrystalline Chalcopyrite CuIn1-xGaxSe2

The highest efficiency CuIn 1-x Ga x Se2 (CIGS) solar cells use thin-film polycrystalline CIGS absorber layers. We have applied variable angle spectroscopic ellipsometry (VASE) to characterize the dielectric functions of polycrystalline thin films of CIGS with Ga: (In + Ga) ratios ranging from 0.18 to 1.0. The Cu: (In + Ga) ratios in these films are approximately 0.90, which is the ratio that yields the highest efficiency CIGS devices. Spectra were measured over the energy range 0.7 to 5.0 eV at room temperatures. Models used to analyze the ellipsometry data include the full multi-layer structure of the sample, which enables us to report the actual dielectric function rather than the pseudo-dielectric function. We present data on how the critical points change with composition, and compare and contrast our results with measurements of single-crystal and bulk polycrystalline samples reported in the literature. Auger electron spectroscopy, atomic force microscopy, and X-ray diffraction have been used to verify the homogeneity, surface roughness, and phase purity, respectively.
Everything Is Data: A Response to Brooke Harrington

L'auteur de Unlocking the Iron Cage , ouvrage qui porte un regard ethnographique sur un groupement masculin mythopoetique, repond a Brooke Harrington sur des questions de methodologie
Prevalence of Financial Fraud and Scams Among Older Adults in the United States: A Systematic Review and Meta-Analysis.

Background. The financial exploitation of older adults was recently recognized by the Centers for Disease Control and Prevention as a serious public health problem. Knowledge of the prevalence of elder financial exploitation is mostly limited to the category of financial abuse, which occurs in relationships involving an expectation of trust. Little is known about the other major category of elder financial exploitation—elder financial fraud and scams, which is perpetrated by strangers. A valid estimate of elder financial fraud–scam prevalence is necessary as a foundation for research and prevention efforts.Objectives. To estimate the prevalence of elder financial fraud–scam victimization in the United States based on a systematic review and meta-analysis.Search Methods. Multiple investigators independently screened titles and abstracts and reviewed relevant full-text records from PubMed, Medline, PsycINFO, Criminal Justice Abstracts, Social Work Abstracts, and AgeLine databases.Selection Criteria. To maxi...
Terahertz Beam Testing of Millimeter Wave Monolithic Integrated Circuits

The measured response of a monolithic microwave integrated circuit (MMIC) to the sub-terahertz (300 GHz) radiation is in qualitative agreement with the analytical theory of the overdamped plasmonic detection and has been used to establish and identify the integrated circuit faults. The bias and polarization dependences of the response measured between the different pins provide information about the faults location. In contrast to a more conventional terahertz and radio frequency imaging and testing techniques, this method relies on the electronic response with the resolution determined by the transistor size. Another advantage of this non-destructive non-contact approach is that the MMICs or VLSIs can be tested either biased or unbiased. Multiple transistors within the circuit or the entire circuit can be tested fast.
Sex differences in emotion recognition ability: The mediating role of trait emotional awareness

Although previous research on emotion recognition ability (ERA) has found consistent evidence for a female advantage, the explanation for this sex difference remains incompletely understood. This study compared males and females on four emotion recognition tasks, using a community sample of 379 adults drawn from two regions of the United States (stratified with respect to age, sex, and socioeconomic status). Participants also completed the Levels of Emotional Awareness Scale (LEAS), a measure of trait emotional awareness (EA) thought to primarily reflect individual differences in emotion concept learning. We observed that individual differences in LEAS scores mediated the relationship between sex and ERA; in addition, we observed that ERA distributions were noticeably non-normal, and that—similar to findings with other cognitive performance measures—males had more variability in ERA than females. These results further characterize sex differences in ERA and suggest that these differences may be explained by differences in EA—a trait variable linked primarily to early learning.
Expression profiling suggests microglial impairment in human immunodeficiency virus neuropathogenesis.

Objective CD16+ /CD163+ macrophages (MΦs) and microglia accumulate in the brains of patients with human immunodeficiency virus (HIV) encephalitis (HIVE), a neuropathological correlate of the most severe form of HIV-associated neurocognitive disorders, HIV-associated dementia. Recently, we found that some parenchymal microglia in brain of HIV+ subjects without encephalitis (HIV/noE) but with varying degrees of neurocognitive impairment express CD16 and CD163, even in the absence of detectable virus production. To further our understanding of microglial activation in HIV, we investigated expression of specific genes by profiling parenchymal microglia from archival brain tissue of patients with HIVE and HIV/noE, and HIV- controls. Methods Single-population microarray analyses were performed on ∼2,500 laser capture microdissected CD163+ , CD16+ , or CD68+ MΦs/microglia per case, using terminal continuation RNA amplification and a custom-designed array platform. Results Several classes of microglial transcripts in HIVE and HIV/noE were altered, relative to HIV- subjects, including factors related to cell stress, immune activation, and apoptosis. Additionally, several neurotrophic factors were reduced in HIV infection, suggesting an additional mechanism of neuropathogenesis. The majority of transcripts altered in HIVE displayed intermediate changes in HIV/noE. Interpretation Our results support the notion that microglia contribute to the maintenance of brain homeostasis and their potential loss of function in the context of chronic inflammation contributes to neuropathogenesis. Furthermore, they indicate the utility of profiling MΦs/microglia to increase our understanding of microglia function, as well as to ascertain alterations in specific pathways, genes, and potentially, encoded proteins that may be amenable to targeted treatment modalities in diseases affecting the brain. Ann Neurol 2018;83:406-417.
Alexander the Great: Man and God

Alexander the Great conquered territories on a superhuman scale and established an empire that stretched from Greece to India. He spread Greek culture and education throughout his empire, and was worshipped as a living god by many of his subjects. But how great is a leader responsible for the deaths on tens of thousands of people? A ruler who prefers constant warring to administering the peace? A man who believed he was a god, who murdered his friends, and recklessly put his soldiers lives at risk? Ian Worthington delves into Alexander's successes and failures, his paranoia, the murders he engineered, his megalomania, and his constant drinking. It presents a king corrupted by power and who, for his own personal ends, sacrificed the empire his father had fought to establish.
Chronic inflammation and cancer in various organ systems

Cancer is one of the leading causes of mortality and morbidity worldwide. The Global Burden of Disease Study estimated that, in 1990, 6 million out of 50.5 million deaths worldwide (12%) were attributable to cancer [1]. Among the top 30 causes of deaths worldwide that year, lung cancer, stomach cancer, liver cancer, colorectal cancer, esophageal cancer, and breast cancer ranked 10th, 14th, 22nd, 24th, 26th and 29th, respectively. In 1999, as per the World Health Organization mortality data, 23% of the total deaths in the United States occurred from cancer [2]. The United Kingdom and Japan reported similar rates at 24% and 30%, respectively. Mortality data from other countries are available at the World Health Organization website (http://www.who.int/en).
γ-GLUTAMYL TRANSPEPTIDASE: PROPERTIES IN RELATION TO ITS PROPOSED PHYSIOLOGICAL ROLE

ABSTRACT. Two rat kidney γ-glutamyl transpeptidase isozymes have been purified. Both contain about 30% carbohydrate; although the amino acid composition is similar, the isozymes show different mobilities on polyacrylamide gels. The isozymes have been examined with respect to their γ-glutamyl donor and acceptor specificities. Both exhibit similar specificities. Several glutathione analogs and derivatives and many γ-glutamyl amino acids were active as γ-glutamyl donors. Glutathione disulfide was about 5% as active as glutathione. Of the amino acids tested, L-glutamine and L-methionine were the best acceptors of the γ-glutamyl group. A number of dipeptides were active as acceptors and several of these were more active than L-glutamine. Aminoacylglycine derivatives were, in the examples studied, more active than the corresponding free NH 2 -terminal amino acids, probably reflecting their affinity for the “cysteinylglycine” site of the enzyme. These and other properties of the transpeptidase isozymes are discussed in relation to the proposed function of the γ-glutamyl cycle in amino acid and peptide transport (Orlowski and Meister, 1970; Meister, 1973). It has also been shown that maleate inhibits transfer of the γ-glutamyl moiety to an acceptor and markedly increases hydrolysis of the γ-glutamyl donor. Thus, glutamine, a poor substrate for transpeptidase as compared to glutathione, is rapidly hydrolysed by transpeptidase in the presence of maleate. Evidence has been obtained suggesting that the previously described “maleate-stimulated phosphate-independent glutaminase” is a catalytic function of transpeptidase.
HMGCoA-reductase inhibitors in dementia: Benefit or harm

Dementia is a syndrome characterized by a decline in cognitive function. Alzheimer’s disease and cerebro-vascular disease are the most common causes of dementia. Many factors (genetic, life style, vascular etc.) appear to play some role in the development of dementia. Statins significantly reduce vascular disease and could reduce cognitive impairment in later life. Although most cross-sectional and longitudinal studies suggested a lower incidence of dementia in long-term statin users, randomized trials of statins in dementia did not slow disease progression. Furthermore, the effect of statins on cognitive performance is not well understood. Case reports suggest that statins may adversely affect cognition in some individuals, and prospective data studying the effects of statins in cognitively normal individuals is limited. Thus, the effects of statins on cognition in late life, remains uncertain.
Estrogen enhances dietary cholesterol induction of saturated bile in the hamster.

The influence of ethinyl estradiol (EE) on the effects of dietary cholesterol on the biliary saturation index and on the rate-limiting hepatic enzymes of cholesterol synthesis, hydroxymethylglutaryl-CoA-reductase, and bile acid synthesis, 7α-hydroxylase, were determined. Four groups of 12 male hamsters were treated for 1 month with EE, 15 µg per kg per day, or placebo vehicle administered intraperitoneally and fed either a standard diet, 0.8 mg of cholesterol per g of food, or high cholesterol diet, 2.4 mg of cholesterol per g. The high cholesterol diet increased the saturation index to 1.00 ± 0.03 (P
The Instrumental Temperature Record

The thermometer, a device for measuring temperature, was developed in the seventeenth century but proper calibration and the development of systematic records did not occur until the nineteenth century. The World Meteorological Organization set up a system for collecting temperature measurements on a global scale early in the twentieth century. Data collection and homogenization have become ever more sophisticated. Records from single sites reflect the chaos of the weather, but when combined into regional analyses show distinct trends. North America appears to be a special case, showing a rise in the first half of the twentieth century, a plateau until about 1970, and a subsequent rise. The same patterns can be seen, but not so distinctly, in European records. It is thought that the rises reflect the increasing levels of atmospheric CO2, and the plateau the industrial pollution of the middle of the century. Records from the tropics show the slowest upward trend, but higher latitude records show more pronounced upward trends.
Making Mobile Networks Fly

Advances in mobile (cellular) networks have ushered in an era of abundant connectivity. However, the stationary and expensive nature of their deployment has limited their ability to provide true "ubiquitous" connectivity under the 5G vision - especially to areas where connectivity is sparing or nonexistent (e.g. rural areas), has been compromised (e.g. disasters), or demands are extreme (e.g. venues/hotspots). The recent advances in un-manned aerial vehicle (UAVs) technology have the potential to change the landscape of wide-area wireless connectivity by bringing a new dimension - "mobility" to the cellular network infrastructure itself. By deploying base stations on each of the UAVs, service providers can now deploy and tear-down these cellular networks "in the sky" in an on-demand and flexible manner. This allows them to supplement static mobile networks in areas where additional connectivity is needed, or provide stand-alone connectivity in areas where existing mobile networks are either absent or compromised. However, realizing this vision of deploying heavy-weight cellular networks (e.g. LTE) on light-weight, resource-constrained platforms such as UAVs, faces several formidable challenges both in design and deployment. This is complicated by the complex nature of cellular networks that involve multiple interacting components - radio access network (RAN), evolved packet core (EPC) network and backhaul transport network. In this talk, I will present our system "SkyLiTE"-- one of the first efforts to design and deploy an on-demand, end-to-end, multi-cell LTE network (on UAVs) that can self-configure itself in the sky. I will discuss how SkyLiTE re-architects the various components (RAN, core and backhaul) of a cellular network to make it deployable on challenging UAV platforms in highly dynamic environments. We believe the validation of SkyLiTE in real-world deployments, will help contribute to a new era of mobile networks that can fly and make connectivity both abundant and ubiquitous.
Micro: bit Magic: Engaging K-12, CS1/2, and Non-majors with IoT & Embedded

Are you interested in a fun way to introduce a variety of students to significant contemporary CS topics, like wireless networking, robotics, and the Internet of Things (IoT)? Do you want to do so using a platform that is cheap, has a low-barrier to entry, but where learning can translate to the real world and where advanced students can pursue advanced topics? If so, you need a micro:bit! The micro:bit is a platform developed by the British Broadcasting Corporation (BBC) to encourage children to pursue computing and electronics. Although designed for children, its capabilities are sufficient for a variety of postsecondary applications. It includes a 32-bit processor, lights, buttons, an accelerometer, digital I/O, and wireless communication, making it ideal for wearables and robotics. It also leverages some of the latest trends in introductory computing, like support for block-based languages (ala Scratch), while also being sophisticated enough for complex topics in Operating Systems and Networking This workshop will introduce the micro:bit and focus on engaging, lightweight coverage of complex topics, including robotics, mesh networks, and IoT. Participants will work through classroom-ready exercises suitable for K-12 workshops, student recruiting events, CS0/1/2, or as bootstrap topics in IoT courses. The workshop will include some subjects not commonly covered in existing micro:bit material, like integration with mobile apps and IoT applications. Participants will be provided with hardware but will need a laptop with internet access and a mobile device (any OSes, but some features work better with iOS).
Use cases for genetic epidemiology in malaria elimination

While traditional epidemiological approaches have supported significant reductions in malaria incidence across many countries, higher resolution information about local and regional malaria epidemiology will be needed to efficiently target interventions for elimination. The application of genetic epidemiological methods for the analysis of parasite genetics has, thus far, primarily been confined to research settings. To illustrate how these technical methods can be used to advance programmatic and operational needs of National Malaria Control Programmes (NMCPs), and accelerate global progress to eradication, this manuscript presents seven use cases for which genetic epidemiology approaches to parasite genetic data are informative to the decision-making of NMCPs. The use cases were developed through a highly iterative process that included an extensive review of the literature and global guidance documents, including the 2017 World Health Organization’s Framework for Malaria Elimination, and collection of stakeholder input. Semi-structured interviews were conducted with programmatic and technical experts about the needs and opportunities for genetic epidemiology methods in malaria elimination. Seven use cases were developed: Detect resistance, Assess drug resistance gene flow, Assess transmission intensity, Identify foci, Determine connectivity of parasite populations, Identify imported cases, and Characterize local transmission chains. The method currently used to provide the information sought, population unit for implementation, the pre-conditions for using these approaches, and post-conditions intended as a product of the use case were identified for each use case. This framework of use cases will prioritize research and development of genetic epidemiology methods that best achieve the goals of NMCPs, and ultimately, inform the establishment of normative policy guidance for their uses. With significant engagement of stakeholders from malaria endemic countries and collaboration with local programme experts to ensure strategic implementation, genetic epidemiological approaches have tremendous potential to accelerate global malaria elimination efforts.
Developmental Level of Moral Judgment Influences Behavioral Patterns During Moral Decision-Making

We developed and tested a behavioral version of the Defining Issues Test-1 revised (DIT-1r), which is a measure of the development of moral judgment. We conducted a behavioral experiment using the ...
The Role of Web Assurance Seals in Nonprofit Giving

Using a sample of the 2,000 largest nonprofit organizations in the US, we document that the use of web assurance seals is not as commonplace as for-profit e-commerce websites. In particular we find...
Ventricular Fibrillation Associated With Coronary Plaque Erosion Detected by Optical Coherence Tomography.

A 49-year old athletic man was in his usual state of health until 2 weeks before admission when he began to experience intermittent chest discomfort with moderate levels of physical activity. On the day of admission, he noted a more sustained episode and he called 911. While en route to the
An Inducible Cre-lox System to Analyze the Role of LLO in Listeria monocytogenes Pathogenesis

Listeriolysin O (LLO) is a pore-forming cytolysin that allows Listeria monocytogenes to escape from phagocytic vacuoles and enter the host cell cytosol. LLO is expressed continuously during infection, but it has been a challenge to evaluate the importance of LLO secreted in the host cell cytosol because deletion of the gene encoding LLO (hly) prevents localization of L. monocytogenes to the cytosol. Here, we describe a L. monocytogenes strain (hlyfl) in which hly is flanked by loxP sites and Cre recombinase is under the transcriptional control of the L. monocytogenes actA promoter, which is highly induced in the host cell cytosol. In less than 2 h after infection of bone marrow-derived macrophages (BMMs), bacteria were 100% non-hemolytic. hlyfl grew intracellularly to levels 10-fold greater than wildtype L. monocytogenes and was less cytotoxic. In an intravenous mouse model, 90% of bacteria were non-hemolytic within three hours in the spleen and eight hours in the liver. The loss of LLO led to a 2-log virulence defect in the spleen and a 4-log virulence defect in the liver compared to WT L. monocytogenes. Thus, the production of LLO in the cytosol has significant impact on the pathogenicity of L. monocytogenes.
Write Like a Pro or an Amateur? The Effect of Medical Language Formality in Senior Care: A Multi-Method Approach

As the world’s senior population grows rapidly, complex senior care problems pose significant challenges for family caregivers, partially because of their limited medical literacy and information asymmetry. To alleviate such challenges, family caregivers participate in senior care forums to share problems and experiences. Although studies indicate that this caregiver-generated online health information benefits patients, how such information can be perceived easily and correctly remain unclear. This study aims to fill this gap by exploring mechanisms to improve the helpfulness of online health information. Specifically, we investigate the effect of medical language formality. We propose a multi-method framework, including a novel Medical-Enriched DEep Learning (MEDEL) feature extraction method, econometric analyses, and a randomized experiment. The MEDEL model extracts independent variables for the econometric analyses. The econometric analyses and randomized experiment provide consistent evidence that when the medical language of health information is informal, the senior care information is more helpful. This study contributes to IS theory, methodology, and practice. We bridge the gap between medical language formality and information helpfulness in senior care. Our findings provide a theoretical foundation to understand the influence of language formality on many other business communications. Our proposed multi-method approach can also be generalized to investigate research questions involving complex textual features. Forum sites could leverage our proposed approach to improve the helpfulness of online health information and user satisfaction.
Closed-form expressions for the magnetic fields of rectangular and circular finite-length solenoids and current loops

A summary of closed-form expressions for the magnetic fields produced by rectangular- and circular-shaped finite-length solenoids and current loops is provided altogether for easy reference. Each expression provides the magnetic field in all space, except locations where a current of infinitesimal thickness is considered to exist. The closed-form expression for the magnetic field of a rectangular-shaped finite-length solenoid is derived using the Biot–Savart law. Closed-form expressions for the magnetic fields of solenoids and current loops can be used to avoid approximations in analytical models and may reduce computation time in computer simulations.
A Call to Travel: Teaching African American Literature via Study Abroad

In this chapter, I document the connection of travel to the African American literary tradition from slave narratives to migration narratives. The text argues that travel is a fundamental trope within African American literature and promotes teaching the trope through study abroad.
Simulated Pressure Field and Directivity of Phased Arrays

In order to achieve the best performances of phased arrays, it is of essential importance to study the transducer parameters including the number of elements (N), inter-element spacing (d), element width (a), and steering angle (θS). Several studies discussed the effects of the parameters. For example, it was pointed out by Steinberg that the inter-element spacing be less than half the wavelength, i.e., d < λ/2 [1]. Other works include the studies by Lemon and Posakony [2], von Ramm and Smith [3], Smith et al. [4], Turnbull and Foster [5], and Lockwood et al. [6].
Electronically Modified Cobalt Aminopyridine Complexes Reveal an Orthogonal Axis for Catalytic Optimization for CO2 Reduction.

The design of effective electrocatalysts for carbon dioxide reduction requires understanding the mechanistic underpinnings governing the binding, reduction, and protonation of CO2. A critical aspec...
Higher order mode damper for low energy RHIC electron cooler superconducting radio frequency booster cavity

To improve RHIC luminosity for heavy ion beam energies below $10\text{ }\text{ }\mathrm{GeV}/\text{nucleon}$, the Low Energy RHIC electron Cooler (LEReC) is currently under commissioning at BNL. The linac of LEReC is designed to deliver a 1.6--2.6 MeV electron beam, with rms $dp/p$ less than $5\ifmmode\times\else\texttimes\fi{}{10}^{\ensuremath{-}4}$. A 704 MHz superconducting radio frequency booster cavity in this linac provides up to 2.2 MeV accelerating voltage. With such a low energy and very demanding energy spread requirement, control of higher order modes (HOMs) in the cavities becomes critical and needs to be carefully evaluated to ensure minimum impact on the beam. In this paper, we report the multiphysics design of the HOM damper for this cavity to meet the energy spread requirement, as well as experimental results of the cavity with and without the HOM damper.
Opioid Prescribing Patterns Among Facial Plastic and Reconstructive Surgeons in the Medicare Population.

Objective: To evaluate opioid prescribing patterns among American Academy of Facial Plastic and Reconstructive Surgery (AAFPRS) members in the Medicare population. Methods: Retrospective cohort stu...
Relationship between hepatitis C virus (HCV) IgG index values and quantitative HCV RNA results in HCV IgG-reactive serum samples.

Abstract Centers for Disease Control guidelines recommend hepatitis C virus (HCV) RNA testing of all HCV IgG-reactive samples, although earlier studies found that IgG-reactive samples with low indices were negative in qualitative RNA assays. To determine if previous study results could be confirmed using current real-time RT-PCR technology, we investigated the relationship between HCV IgG index (Ortho VITROS) and quantitative HCV RNA results (cobas HCV) for 2368 consecutive IgG-reactive sera. Results were segregated into Low (1.00–16.0), Medium (16.1–30.0), and High (>30.0) IgG index groups. Although median viral load (VL) of RNA-positive samples was similar in all 3 groups, the percentage with low VL (1.18–4.16 log IU/mL) was increased for the Low group. Further analysis of the Low group revealed that 23 of 370 (6%) samples with IgG indices ≤8.00 were RNA-positive, and 13/23 (57%) had low VL. Our analysis supports the Centers for Disease Control recommendation to test all HCV IgG-reactive sera for HCV RNA.
Basics for Improved Use of Phages for Therapy

Blood-borne therapeutic phages and phage capsids increasingly reach therapeutic targets as they acquire more persistence, i.e., become more resistant to non-targeted removal from blood. Pathogenic bacteria are targets during classical phage therapy. Metastatic tumors are potential future targets, during use of drug delivery vehicles (DDVs) that are phage derived. Phage therapy has, to date, only sometimes been successful. One cause of failure is low phage persistence. A three-step strategy for increasing persistence is to increase (1) the speed of lytic phage isolation, (2) the diversity of phages isolated, and (3) the effectiveness and speed of screening phages for high persistence. The importance of high persistence-screening is illustrated by our finding here of persistence dramatically higher for coliphage T3 than for its relative, coliphage T7, in murine blood. Coliphage T4 is more persistent, long-term than T3. Pseudomonas chlororaphis phage 201phi2-1 has relatively low persistence. These data are obtained with phages co-inoculated and separately assayed. In addition, highly persistent phage T3 undergoes dispersal to several murine organs and displays tumor tropism in epithelial tissue (xenografted human oral squamous cell carcinoma). Dispersal is an asset for phage therapy, but a liability for phage-based DDVs. We propose increased focus on phage persistence-and dispersal-screening.
Nickel-based electrochemical sensor with a wide detection range for measuring hydroxyl ions and pH sensing.

Abstract The importance of hydroxyl ions concentration measurement in solution necessitates the development of suitable and simple sensing methods for online detection. To address this need, an electrochemical sensor was developed using nickel as the working electrode that enabled specificity towards hydroxyl ions and their successfully quantification. The electrochemical reaction between nickel and hydroxyl ions in solution generates a current which is proportional to the concentration of hydroxyl ions and consequently is also correlated to the pH of the solution. Cyclic voltammetry and chronoamperometry techniques were used to prepare and activate the nickel electrode for detection. The analysis of chronoamperometric experiments in different solutions exhibited three calibration curves between the current and hydroxyl ion concentrations for three regions in the range of 0.3 µM to 4.8 M with a short response time of 14 s. Up to now, no other hydroxyl ion sensor has been reported that can reach this detection limit. This sensor also holds promise to work perfectly in highly alkaline environments where only costly commercial electrodes are available to quantify pH. The results show three linear calibration curves between the current and pH of the solution over the pH range of 7.4 to 14.6. In addition to the wide detection range, the sensor exhibits a relative standard deviation percentage lower than 7% over 9 months of experiments, confirming repeatability of measurements and stability of the electrode. The potential of the proposed method to measure pH in real applications was demonstrated by testing the sensor in solutions containing urea, nitrates, phosphates, and sulfates.
The Rare, the Odd, and the Atypical: A Pictorial Essay of Testicular and Paratesticular Diseases.

ABSTRACT Understanding a variety of scrotal diseases is essential to developing an accurate differential diagnosis and is critical in providing optimal patient care. Ultrasound is the imaging modality of choice when evaluating for scrotal pathology, with the major purpose of locating such pathology to either the testis, or epididymis, or other intrascrotal structures, as well as characterizing lesions as solid or cystic. It is generally assumed that most solid intratesticular masses are more likely malignant, whereas most extratesticular ones are benign, although some exceptions to that rule exist. This pictorial essay will focus on rare and less commonly encountered benign and malignant testicular and paratesticular pathologies, which may pose a diagnostic dilemma for interpreting radiologists and treating physicians. Knowledge of their imaging characteristics will help narrow the differential diagnosis and assist in proper patient management and care.
Post-training intra-basolateral complex of the amygdala infusions of clenbuterol enhance memory for conditioned place preference and increase ARC protein expression in dorsal hippocampal synaptic fractions.

Abstract The basolateral complex of the amygdala (BLA) is critically involved in modulation of memory by stress hormones. Noradrenergic activation of the BLA enhances memory consolidation and plays a necessary role in the enhancing or impairing effects of stress hormones on memory. The BLA is not only involved in the consolidation of aversive memories but can regulate appetitive memory formation as well. Extensive evidence suggests that the BLA is a modulatory structure that influences consolidation of arousing memories through modulation of plasticity and expression of plasticity-related genes, such as the activity regulated cytoskeletal-associated (Arc/Arg 3.1) protein, in efferent brain regions. ARC is an immediate early gene whose mRNA is localized to the dendrites and is necessary for hippocampus-dependent long-term potentiation and long-term memory formation. Post-training intra-BLA infusions of the β-adrenoceptor agonist, clenbuterol, enhances memory for an aversive task and increases dorsal hippocampus ARC protein expression following training on that task. To examine whether this function of BLA noradrenergic signaling extends to the consolidation of appetitive memories, the present studies test the effect of post-training intra-BLA infusions of clenbuterol on memory for the appetitive conditioned place preference (CPP) task and for effects on ARC protein expression in hippocampal synapses. Additionally, the necessity of increased hippocampal ARC protein expression was also examined for long-term memory formation of the CPP task. Immediate post-training intra-BLA infusions of clenbuterol (4 ng/0.2 µL) significantly enhanced memory for the CPP task. This same memory enhancing treatment significantly increased ARC protein expression in dorsal, but not ventral, hippocampal synaptic fractions. Furthermore, immediate post-training intra-dorsal hippocampal infusions of Arc antisense oligodeoxynucleotides (ODNs), which reduce ARC protein expression, prevented long-term memory formation for the CPP task. These results suggest that noradrenergic activity in the BLA influences long-term memory for aversive and appetitive events in a similar manner and the role of the BLA is conserved across classes of memory. It also suggests that the influence of the BLA on hippocampal ARC protein expression and the role of hippocampal ARC protein expression are conserved across classes of emotionally arousing memories.
Biopsy Interpretation of the Central Nervous System

Biopsy interpretation of the central nervous system - Libros de Medicina - Patologia - 143,00
Primate models of children's health and developmental disabilities

The rate of neurodevelopmental disabilities, including autism, mental retardation, hearing loss and attention deficit hyperactivity disorder is rising in the United States. Although estimates of the prevalence of these disorders vary, figures from the CDC indicate that 4 per cent of all school age children are developmentally disabled. During infancy, many important milestones in behavioral development are shared between human and nonhuman primates. Learning more about the causes of abnormal development in monkeys has provided important insights into the mechanisms underlying neurodevelopmental disabilities in human infants.This book documents the latest research not commonly found in other references, and provides a comprehensive look at the results from decades of work with nonhuman primates as it relates to child development and disability. It includes hot topics such as early chemical exposures, immunological influences on development, low birth weight, endocrine disrupters, pediatric AIDS, origin of childhood psychopathologies and assisted reproductive technology. It represents the significant body of work accumulated since funding for research on developmental disabilities has increased substantially in recent years.
Zytotoxizitäts-Assays mittels Imaging und Lumineszenz

Cytotoxicity is still a major cause for the failure of potential drugs in clinical trials and there is an urgent need for reliable and time-saving tests. Since compounds can interfere with a wide variety of biochemical processes, it is very important to analyze several parameters in orthogonal approaches.
Globally optimal tradeoff curves for OFDM PAR reduction [peak-to-average power ratio]

This paper describes an efficient convex optimization technique for computing the globally optimal tradeoff curves between OFDM peak-to-average power ratio (PAR), constellation error, and free carrier power. The OFDM system designer can select a suitable PAR reduction method by comparing the achieved performance of various algorithms with these optimal tradeoff curves. Simulation results are presented for the 802.11a/g WLAN standard. The power wasted in the free carriers can be substantially reduced by taking advantage of the allowed constellation error and by backing off 1 dB from the globally minimum PAR. A convex interior-point method reaches the desired tradeoff point within two iterations for both QPSK and 64-QAM.
Osteogenesis in vitro: from pre-osteoblasts to osteocytes: a contribution from the Osteobiology Research Group, The Pennsylvania State University.

Murine calvariae pre-osteoblasts (MC3T3-E1), grown in a novel bioreactor, proliferate into a mineralizing 3D osteoblastic tissue that undergoes progressive phenotypic maturation into osteocyte-like cells. Initially, the cells are closely packed (high cell/matrix ratio), but transform into a more mature phenotype (low cell/matrix ratio) after about 5 mo, a process that recapitulates stages of bone development observed in vivo. The cell morphology concomitantly evolves from spindle-shaped pre-osteoblasts through cobblestone-shaped osteoblasts to stellate-shaped osteocyte-like cells interconnected by many intercellular processes. Gene-expression profiles parallel cell morphological changes, up-to-and-including increased expression of osteocyte-associated genes such as E11, DMP1, and sclerostin. X-ray scattering and infrared spectroscopy of contiguous, square centimeter-scale macroscopic mineral deposits are consistent with bone hydroxyapatite, showing that bioreactor conditions can lead to ossification reminiscent of bone formation. Thus, extended-term osteoblast culture (≤10 mo) in a bioreactor based on the concept of simultaneous growth and dialysis captures the full continuum of bone development otherwise inaccessible with conventional cell culture, resulting in an in vitro model of osteogenesis and a source of terminally differentiated osteocytes that does not require demineralization of fully formed bone.
In vivo visualization of the development of the enteric nervous system using a Tg(−8.3bphox2b:Kaede) transgenic zebrafish

The phox2b gene encodes a transcription factor that is expressed in the developing enteric nervous system (ENS). An enhancer element has been identified in the zebrafish phox2b locus that can drive tissue specific expression of reporter genes in enteric neuron precursor cells. We have generated a transgenic zebrafish line in which the Kaede fluorescent protein is under the control of this phox2b enhancer. This line has stable expression of the Kaede protein in enteric neuron precursor cells over three generations. To demonstrate the utility of this line we compared the migration and division rates of enteric neuron precursor cells in wild type and the zebrafish ENS mutant lessen.
Ancient Cuzco: Heartland of the Inca

Ancient Cuzco: Heartland of the Inca. Brian S. Bauer. Austin: University of Texas Press, 2004. 255 pp.