cssi/SciSciGPT-SciSciNet huggingface dataset:
Prediction of the Dissipation of a Solid-Rocket Contrail

Starting with predictions of solid-propellant-rocket plume-gas temperatures and compositions, and secondary smoke droplet properties from literature cited computer programs, a new model of the dissipation of a rocket contrailispresented.Equationsdescribingthegrowthandevaporationofthesecondarysmokedropletscomprising the contrail with time and plume location aregiven. Gravity settling of the droplets, thechange of gas temperature and composition with time by diffusion, and the initial location of the droplets in the plume control the contrail dissipation. An example is given for a typical 87 wt % ammonium perchlorate, 1 wt % aluminum, and 12 wt % rubberbindersolid-propellant (reduced smoke )rocket e ying horizontally at 200 ft/sthrough airat sea level, 22 ± C, and 96% relative humidity.
Use of Intestinal Loops for Revascularization of the Heart

Intestinal loops brought up through the diaphragm and attached to the myocardium will cause the formation of connections between the vascular supplies of the heart and intestine. The vessels that develop between these two organs are large enough to transmit thick suspensions of barium sulfate. India ink injected in the mesenteric vessel can be readily found on all surfaces of the heart as well as deep within the myocardium.
Performance of the first refurbished CEBAF cryomodule

The Thomas Jefferson national accelerator facility has begun a cryomodule refurbishment project. The goal of this project is robust 6 GeV, 5 pass operation of the continuous electron beam accelerator facility (CEBAF). The scope of the project includes removing, refurbishing and replacing 10 CEBAF cryomodules at a rate of three per year. Refurbishment includes reprocessing of SRF cavities to eliminate field emission and increase the nominal gradient from the original 5 MV/m to 12.5 MV/m. New "dogleg" couplers between the cavity and helium vessel flanges will intercept secondary electrons that produce arcing on the 2 K ceramic window in the fundamental power coupler (FPC). Modification of the Qext of the FPC will allow higher gradient operations. Other changes include new ceramic RF windows for the air to vacuum interface of the FPC and improvements to the mechanical tuners. Any damaged or worn components will be replaced as well. Currently, the first of the refurbished cryomodules has been installed and tested both in the cryomodule test facility and in place in the North Linac of CEBAF. This paper will summarize the results of these tests.
Air and Water Sterilization using Non-Thermal Plasma

Summary form only given. Various investigations have proven the effectiveness of nonthermal plasma against microorganisms. This sterilization effect is of great importance in countering the threat of bioterrorism. So far, most of sterilization studies have been in the direction of surface sterilization. The sterilization effect of plasma on air and water were investigated in this study. For air sterilization, a small scale model of HVAC was designed and dielectric barrier discharge plasma source was used for treatment of air. This PDRF (Pathogen Detection and Remediation Facility) consisted of a circulatory airflow system, a plasma chamber and a sampling system. The airflow was set to mimic actual air flow in an HVAC system (25 L/sec). The bacterium E coli have been used as a prototype bacterium in these experiments. It is a gram negative non-spore forming bacteria. E coli bacteria were cultured in liquid broth media and grown overnight. The bacterial containing aerosol was introduced into the system using a collision nebulizer. Air sampling system consisted of AGI Air Samplers. The plasma discharge was then ignited. This created a "screen" of plasma across the chamber and the entire contaminated air stream was treated. Air samples taken from the system were analyzed using the plate count method and flow cytometry. The first pass through this screen of plasma produced greater than 1 log reduction and by the time of the second treatment with plasma, the 5 log reduction had been achieved. The present study provides data on the effectiveness of the sterilization action of pulsed spark discharge in water containing Escherichia coli (E. coli). Potable water containing E.coli was treated with a pulsed spark discharge system. The other discharge systems used for water sterilization: pulsed corona, gliding arc and DC discharge over the water were also investigated for comparison. The present study demonstrated that a rather low energy input of 400-600 J/ml of water was required to obtain a one-log reduction in E. coli concentration. The energy consumption for other plasma sources used for water sterilization (corona, gliding arc and DC discharge) to obtain the same sterilization effect was much higher.
Studies in chemical ionization mass spectrometry: Aryl Ketones

The CI mass spectra of aryl ketones, πCOR, were studied and found to give primarily [M + 29]+, [M + 1]+, [M − 1]+, [πCO]+ and [RCO]+ ions. The major change in the spectra with increasing length of the aliphatic side chain was an increase in the [M − 1]+/[M + 1]+ ratio. Increasing sample size was reflected primarily in the formation of [2M + 1]+ ions and a decrease in [M + 1]+ ions. Small amounts of water in the reactant gas reduced the extent of fragmentation action.
APPROXIMATE FIBRATIONS AND BUNDLE MAPS ON HILBERT CUBE MANIFOLDS

Abstract This paper is concerned with parameterized families of approximate fibrations from a compact Hilbert cube manifold M to a compact polyhedron B. The main result shows how to straighten out certain of these families to be nearly like a product. As an application of this technique, it is shown that an approximate fibration p:M → B can be approximated arbitrarily closely by bundle maps if and only if p is homotopic via approximate fibrations to a bundle map. Another result is that the space of bundle maps from M to B is locally n-connected for each n ⩾ 0.
Tolerability and dosing experience of intravenous levetiracetam in children and infants.

Summary Objective To evaluate the use and tolerability of intravenous (IV) levetiracetam (LEV) in a pediatric cohort under 14 years of age. Methods A retrospective analysis of the use of the IV formulation of LEV was performed for the first 9 months that it was available in our institution. Results Overall, 118 infusions in 15 patients were performed during the period assessed. No adverse reactions were observed during the infusion phase of the IV formulation. Nine minor adverse reactions were observed during the rest of the hospitalization that were potentially related to the IV formulation. Three of these were decreases in the white cell counts, while the majority of the rest were behavioral adverse effects. The median starting dose in LEV naive patients was 8.8 mg/kg (range = 5.0–50), with a median maintenance dose of 30.4 mg/kg/day for all patients (range = 5.0–92). The majority of these infusions (82/118) were in a subgroup of children under 4 years of age where the median maintenance dose was 28 mg/kg/day. Conclusion IV LEV was very well tolerated in this cohort of pediatric patients including a subgroup of children under the age of 4 years.
Use of SF5CF3 for ocean tracer release experiments

[1] SF6 tracer release experiments (TREs) have provided fundamental insights in many areas of Oceanography. Recently, SF6 has emerged as a powerful transient tracer, generating a need for an alternative tracer for large-scale ocean TREs. SF5CF3 has the potential to replace SF6 in TREs, due to similarities in their properties and behavior, as well as techniques for injection, sampling, and analysis. The suitability of SF5CF3 for TREs was examined in Santa Monica Basin, off the coast of Southern California. In January 2005, a mixture of ca. 10 mol of both SF6 and SF5CF3 was injected on an isopycnal surface near 800 m depth. Over the next 23 months, concentrations of the two tracers mirrored each other very closely, indicating that SF5CF3 is a viable replacement for SF6 in ocean TREs. The mixing parameters inferred from the experiment confirmed the results from an earlier SF6 TRE in the Santa Monica Basin.
A Low-Power Field-Programmable Gate Array Routing Fabric

This paper describes a new programmable routing fabric for field-programmable gate arrays (FPGAs). Our results show that an FPGA using this fabric can achieve 1.57 times lower dynamic power consumption and 1.35 times lower average net delays with only 9% reduction in logic density over a baseline island-style FPGA implemented in the same 65-nm CMOS technology. These improvements in power and delay are achieved by 1) using only short interconnect segments to reduce routed net lengths, and 2) reducing interconnect segment loading due to programming overhead relative to the baseline FPGA without compromising routability. The new routing fabric is also well-suited to monolithically stacked 3-D-IC implementation. It is shown that a 3-D-FPGA using this fabric can achieve a 3.3 times improvement in logic density, a 2.51 times improvement in delay, and a 2.93 times improvement in dynamic power consumption over the same baseline 2-D-FPGA.
Reactive barrier films

Immobile reactive groups within films used as packaging materials can retard transport of solutes like oqgen and water uapor. A theoy developed for these films shows that these groups do not affect the steady-state transport across the film, but that they do increase the time before permeability begins. The theory is verified by experiments with acid barriers made of polyvinylalcohol containing colloidal zinc oxide. These results imply that the time that barrier polymers are effectiue can be increased about two orders of magnitude. When reactive groups are combined with impermeable flakes, this time can be increased about three orders of magnitude. For example, a polymer barrier currently effective for one hour can be made effectiue for over one year.
Size effect in Paris law and fatigue lifetimes for quasibrittle materials: Modified theory, experiments and micro-modeling

Abstract Unlike brittle materials, quasibrittle materials exhibit a structure size effect on the fatigue crack growth rate, particularly on the Paris law coefficient (prefactor). This size effect is strong for specimens not much larger than the dominant material inhomogeneities (or aggregate sizes in concrete), and vanishes for very large structures. It can be quantified by a size adjustment of Paris law which is similar to the size effect law for monotonic loading. But the transitional size D 0 c at which the transition is centered is not the same. Previous experiments aimed at quantitative analysis of this size effect involved only one or a few specimens per size. Thus the huge scatter, inevitable in fatigue tests, distorted the estimates of D 0 c and, thereby, also of the size of the cyclic fracture process zone (FPZ), to which D 0 c is proportional. Here, more reliable estimates of D 0 c and the cyclic FPZ size are obtained by conducting, on concrete, multiple fatigue tests per size and taking the average. Furthermore, these length characteristics are also estimated numerically using the latest version of the microplane constitutive damage model for concrete (model M7), extended to quasibrittle fatigue. It is conclusively shown that the cyclic FPZ is smaller than the monotonic FPZ. Further, the numerical simulations of the cyclic deformations within the FPZ reveal that the D 0 c obtained from the previous form of the size-adjusted Paris law is not proportional to the cyclic FPZ size. A new form is proposed and verified by updated dimensional analysis. It involves the transitional sizes for both the monotonic and cyclic size effects and is seen to yield values of D 0 c that are proportional to the cyclic FPZ size. The ensuing size effect on fatigue lifetimes is simulated using both the previous and new forms. Both forms are found to predict a non-monotonic size effect on the lifetimes, initially decreasing and, after a minimum, eventually increasing with increasing size. It is also shown that, similar to Paris law for brittle fatigue, an extension to the fatigue threshold at nearly vanishing amplitude is impossible because of a transition to Charles–Evans law for static fatigue. Finally, a possible ramification to fatigue of micrometer-scale metallic devices is pointed out.
Analyzing U.S. prescription lists with RxNorm and the ATC/DDD Index

Objectives: To evaluate the suitability of the ATC/DDD Index (Anatomical Therapeutic Chemical (ATC) Classification System/Defined Daily Dose) for analyzing prescription lists in the U.S. Methods: We mapped RxNorm clinical drugs to ATC. We used this mapping to classify a large set of prescription drugs with ATC and compared the prescribed daily dose to the defined daily dose (DDD) in ATC. Results: 64% of the 11,422 clinical drugs could be precisely mapped to ATC. 97% of the 87,001 RxNorm codes from the prescription dataset could be classified with ATC, and 97% of the prescribed daily doses could be assessed. Conclusions: Although the mapping of RxNorm ingredients to ATC appears to be largely incomplete, the most frequently prescribed drugs in the prescription dataset we analyzed were covered. This study demonstrates the feasibility of using ATC in conjunction with RxNorm for analyzing U.S. prescription datasets for drug classification and assessment of the prescribed daily doses.
Real Time Spectroscopic Ellipsometry of Amorphous Silicon Grown at High Deposition Rates by Hot-Wire CVD

We use real-time spectroscopic ellipsometry (RTSE) for in-situ characterization of the optical properties and surface roughness (Rs) of hydrogenated amorphous silicon (a-Si:H) grown by hot-wire chemical vapor deposition (HWCVD) with varying deposition rates (5 to 120 A/s). Early time evolution of the Rs during growth is remarkably similar for all deposition rates. During the first few As of growth, there is a sharp increase in Rs as the a-Si:H nucleates in separate islands. This is followed by a reduction of Rs as these areas coalesce into a bulk film, which occurs at an average thickness of 100 A. After coalescence the Rs rises to a stable value that is dependent upon growth conditions with a general tendency for the Rs to increase with growth rate. However, neither the Rs nor the material electronic properties are unique for a given deposition rate. Films grown under high silane flow and low pressure have a better photoresponse and a lower Rs than films grown at the same deposition rate but with low silane flow and high pressure. We observe a stronger correlation of film properties with Rs than with deposition rate; namely a monotonic decrease in photo-response, and increase in optical gap, with increasing Rs.
Cutaneous Reactions to Corticosteroids

Corticosteroids have been used for decades. Their anti-inflammatory properties have been shown to be highly effective in a variety of autoimmune conditions as well as those with an increased inflammatory response. The undesirable effects of corticosteroids include the decrease in production of dermal infrastructure cells such as fibroblasts and mast cells, with increased development of structural proteins and complexes. This, in turn, leads to the development of a variety of skin maladies including striae, milia, telangiectasias, purpura, striae distensae, stellate tears of the skin, and atrophy. Its vasodilatory effects contribute to the development of rosacea, acne, folliculitis, and perioral dermatitis. It promotes bacterial and fungal (especially candididiasis) superinfection while introducing a foreign substance capable of inducing a hypersensitive response. Ultimately, the practictioner should be cognizant of these complications, especially in patients with long-term use, and should taper and supplement with adjunctive medications whenever possible.
Draft Whole-Genome Sequences of 10 Enterotoxigenic Escherichia coli Serogroup O6 Strains.

ABSTRACT Enterotoxigenic Escherichia coli (ETEC) is an important cause of diarrhea in children under the age of 5 years and in adults living in developing countries, as well as in travelers to these countries. In this announcement, we release the draft whole-genome sequences of 10 ETEC serogroup O6 strains.
Retrieval of source-extent parameters and the interpretation of corner frequency

Abstract A method is proposed for retrieving source-extent parameters from far-field body-wave data. At low frequency, the normalized P - or S -wave displacement amplitude spectrum can be approximated by |Ω^( r^ , ω )| = 1 − τ 2 ( r^ ) ω 2 /2 where r^ specifies a point on the focal sphere. For planar dislocation sources, τ 2 ( r^ ) is linearly related to statistical measures of source dimension, source duration, and directivity. τ 2 ( r^ ) can be measured as the curvature of |Ω^( r^ , ω )| at ω = 0 or the variance of the pulse Ω^( r^ , t ). The quantity ω c = 2 τ − 1 ( r ^ ) is contrasted with the traditional corner frequency ω 0 , defined as the frequency at the intersection of the low- and high-frequency trends of |Ω^( r^ , ω )|. For dislocation models without directivity, ω c ( P ) ≧ ω c ( S ) for any r^ . A mean corner frequency defined by averaging τ 2 ( r^ ) over the focal sphere, ω ¯ c = 2 τ 2 ( r ^ ) > − 1 / 2 , satisfies ω c ( P ) > ω c ( S ) for any dislocation source. This behavior is not shared by ω 0 . It is shown that ω 0 is most sensitive to critical times in the rupture history of the source, whereas ω c is determined by the basic parameters of source extent. Evidence is presented that ω c is the corner frequency measured on actual seismograms. Thus, the commonly observed corner frequency shift ( P -wave corner greater than the S -wave corner), now viewed as a shift in ω c is simply a result of spatial finiteness and is expected to be a property of any dislocation source. As a result, the shift cannot be used as a criterion for rejecting particular dislocation models.
A Solution of Laplace's Equation for a Semi-Infinite Strip

(1972). A Solution of Laplace's Equation for a Semi-Infinite Strip. Mathematics Magazine: Vol. 45, No. 5, pp. 254-259.
Abstract 1715: Estrogen receptor β induces apoptosis through PUMA independent of p53 in prostate cancer cells.

Estrogen receptor β1’s (ERβ1) expression is reduced during the progression of prostate cancer. In agreement with several studies indicating a tumor suppressive effect of ERβ, we find that expression of ERβ increases apoptosis in the prostate cancer cells. Cells expressing ERβ showed an increase in apoptotic cell population by TUNEL assay and flow cytometric analysis. In addition, cells expressing ERβ showed an increase in sub G1 cell population compared to the control cells. Also, ERβ decreases the expression of anti-apoptotic factor Bcl-2 and increases the expression of the pro-apoptotic factor PUMA. Regulation of PUMA was found to be independent of p53. Although phosphorylation of AKT was decreased by ERβ expression we could not see any reduction of phosphorylated FOXO3A, a known regulator of PUMA. On the other hand total mRNA and protein of FOXO3A increased indicating a direct regulation of FOXO3A by ERβ. Using non-transfected PC3 and LNCaP cells we could observe induction of FOXO3A and PUMA as well as apoptosis in response to added 3β-adiol, DPN or 8β-VE2 indicating that the small amount of ERβ expressed in these cell lines are sufficient to induce apoptosis in response to ERβ specific ligands. Overall, our study indicates an apoptotic action of ERβ and suggests that it can be advantageous to treat prostate cancer with ERβ agonist. Citation Format: Prasenjit Dey, Jan-Ake Gustafsson, Anders M. Strom. Estrogen receptor β induces apoptosis through PUMA independent of p53 in prostate cancer cells. [abstract]. In: Proceedings of the 104th Annual Meeting of the American Association for Cancer Research; 2013 Apr 6-10; Washington, DC. Philadelphia (PA): AACR; Cancer Res 2013;73(8 Suppl):Abstract nr 1715. doi:10.1158/1538-7445.AM2013-1715
The Men in McArthur's Bar: The Cultural Significance of the Margins

“The Men in McArthur's Bar” tells the story of a community of men who resided in Ashcroft, Colorado, a depressed mining town. The article highlights the local sources of a mythic West. In Ashcroft, the imagined West of popular culture merged with a vibrant local storytelling history.
EXPERIMENTAL STUDY ON THE OPTIMIZING OPERATION OF SMELTING REDUCTION

Simulating tests of iron ore reduction in fluidized bed and shaft were made to investi- gate the influences of reduction conditions on gas utilization ratio and essential gas require- ments. The necessary coal quantity for smelting under different pre-reduction parameters is dis- cussed. The optimum conditions of reduction and smelting for minimum energy consumption are analysed.
Librarian as Professional

ABSTRACTWhat does it mean to be a professional, and do librarians meet the academic definition of a professional? Professions are strongly related to identity, and stereotypes associated with the culture of a profession are going to have some effect on the public’s perceptions of that profession. The stereotype of the vaguely purposed but somehow controlling older person (who “shushes” patrons to maintain silence) does not contribute positively to the professional image of a librarian. Library users do not even superficially understand what librarians do, and this leads to an undervaluing of the impact and importance of librarians. In the modern environment of budget challenges, it is important to be able to articulate the value of both libraries and particularly librarians. This article explores the sociological academic literature on professions to determine if librarianship meets the requirements to be a profession, if library literature supports librarianship as a profession, and why it matters for li...
Polymorphism of γ-casein in cow's milk

Abstract γ-Casein occurs in two forms, designated A and B, as measured by disc-gel electrophoresis. The results of the typing of milk samples from 165 cows for β- and γ-casein suggest a genetic basis for the polymorphism of γ-casein and a close relationship in the synthesis of β- and γ-casein.
Happy Birthday, Walter

To the calls for contributions to this book to celebrateWalter Kohn’s eightieth birthday, there will be an outpouring of fond good wishes, as there were for his sixtieth birthday and his seventy-fifth. Walter treats his work colleagues as friends and family. Walter considers Quin Luttinger, a long time collaborator, one of his best friends. When I was his postdoc in La Jolla (1963–66), he introduced the students of Quin Luttinger to me as cousins. T.V. Ramankrishnan was one who comes to mind. Indeed, from Walter’s legion of collaborators, postdocs and students, I have made many friends, with Pierre Hohenberg, Norton Lang, Vinay Ambegaokar, Bill Butler (some of whom would no doubt have their own say in this book), even though we do not meet often.
Markovian Formulation of Computer Network Performance

The performance parameter AVAILABILITY is modeled for a large scale network of communicating computers. From a three state Markovian formulation the steady state Availability function is derived having five transitions probabilities. The function is subjected to sensitivity analysis in order to determine which transition probabilities have the greatest effect on the steady state Availability.
Correlation of Thermally Induced Pores with Microstructural Features Using High Energy X-rays

Combined application of a near-field High Energy Diffraction Microscopy measurement of crystal lattice orientation fields and a tomographic measurement of pore distributions in a sintered nickel-based superalloy sample allows pore locations to be correlated with microstructural features. Measurements were carried out at the Advanced Photon Source beamline 1-ID using an X-ray energy of 65 keV for each of the measurement modes. The nickel superalloy sample was prepared in such a way as to generate significant thermally induced porosity. A three-dimensionally resolved orientation map is directly overlaid with the tomographically determined pore map through a careful registration procedure. The data are shown to reliably reproduce the expected correlations between specific microstructural features (triple lines and quadruple nodes) and pore positions. With the statistics afforded by the 3D data set, we conclude that within statistical limits, pore formation does not depend on the relative orientations of the grains. The experimental procedures and analysis tools illustrated are being applied to a variety of materials problems in which local heterogeneities can affect materials properties.
A Preliminary Investigation Examining the Use of Minor Discipline Referral Data to Identify Students at Risk for Behavioral Difficulties: Observations Within Systems of Schoolwide Positive Behavior Interventions and Supports

ABSTRACTWithin multitiered behavioral frameworks such as schoolwide positive behavior interventions and supports (SWPBIS), it is recommended that schools use multiple sources of data to identify students at risk who may benefit from additional intervention. To date, much of the research in this area has focused on examining either systematic screening data or major office discipline referrals. This study adds to the literature on this topic by examining the extent to which data collected on minor behavior problems may make useful contributions towards identifying students at risk. Using a sample of 597 elementary school students, descriptive and inferential statistical data indicate that minor discipline data may be a useful additional piece of information for schools to consider when screening students for behavioral risk. Additional research is needed to confirm this finding. Implications for practice and research are discussed.
Sports and Hip-Hop, the “Winning at All Costs” Mentality: The Intersection of Academic Fraud and Snitching on Black College Athletes

What impact has the “Winning-at-all-costs” mentality had on college sports? How does this mentality impact African American (The term African American and Black will be used interchangeably (Cavil, The athletic experience at historically Black Colleges and Universities: Past, present, and persistence, 2015)) college athletes and intersect with academic fraud? Although considered commonplace among the sports field, the ambiguity of these questions forges numerous answers. Still, with the inclusion of racial discourse, these questions converge and fuel dialogue on the sociocultural constraints as well as the racial contexts encompassing each facet of the surrounding complexities.
Concerning Induced Operators and Alternating Sequences

When a positive L p -contraction T has a semi-invariant function, then it is related in a natural way to a contraction of L r , where p and r are arbitrary indices in the range (1, ∞). General theorems concerning the pointwise convergence of alternating sequences have been obtained using these induced operators (see [AB,B]). In this note, we study the norm convergence of such sequences, and investigate the existence and uniqueness of induced operators when T is an L 1 -contraction.
The dual frontier: Patented inventions and prior scientific advance

The extent to which scientific advances support marketplace inventions is largely unknown. We study 4.8 million U.S. patents and 32 million research articles to determine the minimum citation distance between patented inventions and prior scientific advances. We find that most cited research articles (80%) link forward to a future patent. Similarly, most patents (61%) link backward to a prior research article. Linked papers and patents typically stand 2 to 4 degrees distant from the other domain. Yet, advances directly along the patent-paper boundary are notably more impactful within their own domains. The distance metric further provides a typology of the fields, institutions, and individuals involved in science-to-technology linkages. Overall, the findings are consistent with theories that emphasize substantial and fruitful connections between patenting and prior scientific inquiry.
Nodular lymphocyte predominant Hodgkin's lymphoma

Nodular LPHL is a pathologic diagnosis distinct from cHL. Its unique pathology contributes to a more indolent clinical behavior than cHL. Although management strategies initially overlapped with therapies recommended for cHL, a growing interest in this unique disease process has led to several prospective clinical trials, particularly in early-stage NLPHL. This has allowed for treatment recommendations for NLPHL to become further defined following an evidence-based approach. Rituximab and radiation therapy have emerged as key components in therapy. Through our study of outcomes of NLPHL patients we have also been able to further define the delayed recurrences that can occur as well as the biologic transformations to TCR-LBCL and DLBCL. Further research is particularly important to increase our understanding of the biological factors that influence transformation as well as the best therapeutic regimens for the treatment of advanced NLPHL as well as NLPHL that has transformed to TCR-LBCL or DLBCL. It is hoped that a continued growth of research in NLPHL will allow us to better stratify treatment approaches and thus improve both short-term and long-term outcomes for the NLPHL patients.
Activation of the unfolded protein response downregulates cardiac ion channels in human induced pluripotent stem cell-derived cardiomyocytes.

Abstract Rationale Heart failure is characterized by electrical remodeling that contributes to arrhythmic risk. The unfolded protein response (UPR) is active in heart failure and can decrease protein levels by increasing mRNA decay, accelerating protein degradation, and inhibiting protein translation. Objective Therefore, we investigated whether the UPR downregulated cardiac ion channels that may contribute to arrhythmogenic electrical remodeling. Methods Human induced pluripotent stem cell-derived cardiomyocytes (hiPSC-CMs) were used to study cardiac ion channels. Action potentials (APs) and ion channel currents were measured by patch clamp recording. The mRNA and protein levels of channels and the UPR effectors were determined by quantitative RT-PCR and Western blotting. Tunicamycin (TM, 50 ng/mL and 5 μg/mL), GSK2606414 (GSK, 300 nmol/L), and 4μ8C (5 μmol/L) were utilized to activate the UPR, inhibit protein kinase-like ER kinase (PERK) and inositol-requiring protein-1 (IRE1), respectively. Results TM-induced activation of the UPR caused significant prolongation of the AP duration (APD) and a reduction of the maximum upstroke velocity (dV/dtmax) of the AP phase 0 in both acute (20–24 h) and chronic treatment (6 days). These changes were explained by reductions in the sodium, L-type calcium, the transient outward and rapidly/slowly activating delayed rectifier potassium currents. Nav1.5, Cav1.2, Kv4.3, and KvLQT1 channels showed concomitant reductions in mRNA and protein levels under activated UPR. Inhibition of PERK or IRE1 shortened the APD and reinstated dV/dtmax. The PERK branch regulated Nav1.5, Kv4.3, hERG, and KvLQT1. The IRE1 branch regulated Nav1.5, hERG, KvLQT1, and Cav1.2. Conclusions Activated UPR downregulates all major cardiac ion currents and results in electrical remodeling in hiPSC-CMs. Both PERK and IRE1 branches downregulate Nav1.5, hERG, and KvLQT1. The PERK branch specifically downregulates Kv4.3, while the IRE1 branch downregulates Cav1.2. Therefore, the UPR contributed to electrical remodeling, and targeting the UPR might be anti-arrhythmic.
Control of a system of loss-in-weight feeders for drug product continuous manufacturing

Abstract Loss-in-weight (LIW) feeders are used to dispense individual materials to the downstream unit operations in continuous drug product manufacturing processes. The purpose of this work was to identify potential material feeding failure modes and demonstrate how a ratio control loop can be used to improve performance for a system of feeders when these disturbances occur and at steady operation. Three feeding failure modes were identified and studied in detail. First, excessive mass flow variability about the setpoint was examined. Next, inaccurate feeding (e.g. consistent over- or under-feeding) relative to setpoint was investigated. Finally, special-cause transient disturbances were explored, which are often generated by hopper refills, external influences to the scale, and/or changes in material properties and flow. These feeding issues impact both the precision and accuracy of the feeding operation. Experiments were executed on a continuous direct compression process utilizing two control modes for the feeders, local (individual feeder control) and ratio (system control in addition to individual feeder control) modes. Ratio mode was proven to be more effective than local mode for feeding the unit formula to the downstream process. Both the precision and accuracy of the output from the system of feeders were improved when using ratio control. For formulas with high feeding variability for drug substances (DS) and excipients, using ratio control improved the DS concentration %RSD at the outlet of the feeders from 5.1% to 2.1% and excipient concentration %RSDs ranging from 2.3–4.9% to 2.3–2.7%. For formulas with good dispensing precision but poor accuracy, ratio control was used to demonstrate improved DS Feeding Accuracy from 97.3% to 101.0% of target. Finally, for formulas that encounter transient disturbances while running in the continuous process, ratio control mode was shown to improve both accuracy and precision during the disturbances, improving the DS concentration %RSDs from 1.9–3.7% to 0.7–1.3% and accuracy values from 104.0–106.5% to 100.2–102.0% of target. Ratio control complements proper equipment configuration selection and individual feeder controller optimization as appropriate techniques used to implement a well performing system of feeders.
Inhibition is associated with metabolic syndrome and depression through inflammation

Inhibition is the ability to stop one's self from responding, or paying attention, to tempting/distracting stimuli or thoughts. Those with poor inhibition are at greater risk of depression and a variety of diseases of older adulthood than those with better inhibition. Inflammation may be a mechanism underlying these links. A total of 840 participants from the Midlife in the United States study completed a neuropsychological measure of inhibition, a self-report measure of depressive symptoms, and a blood draw. Results indicated that poor inhibition was associated with high interleukin-6 (IL-6). Inhibition was indirectly associated with metabolic syndrome incidence and depressive symptoms through IL-6. Findings suggest that IL-6 may be a mechanism linking inhibition with metabolic syndrome and depression.
Forced Convection Heat Transfer with Two-Phase Flow

Two-phase flow with heat transfer is, in the case of cryogenic applications, both frequently encountered and of considerable interest. Since the heat of vaporization is small for most cryogens (approximately 5–100 cal/g), the quality changes rapidly with heat addition. This can result in a relatively short two-phase section which may be difficult to locate if oscillations are present. In any case the quality will vary rapidly, thus complicating the computational process. For hydrogen, Bartlit[1] has developed a method to determine the proper average quality to be used in heat transfer calculations which eliminates the necessity of using an iterative procedure.
Nanodiamond reinforcement in polyamide and polyimide matrices: Fundamentals and applications:

Nanodiamond is an emerging nanocarbon material having several advantageous properties (high surface area, mechanical properties, optical features, wear resistance, low friction coefficient, etc.) a...
Re: “Predicting Risk for Opioid Misuse in Chronic Pain with a Single-Item Measure of Catastrophic Thinking”

To the Editor: I commend Julie Lutz and colleagues[1][1] on their work which advocated predicting risk for opioid misuse in chronic pain with a single-item measure of catastrophic thinking from the Coping Strategies Questionnaire (CSQ). There are, however, two issues that would benefit from
Low-Power Image Recognition Challenge

Cameras have become available in many embedded and mobile systems, including vehicles, smartphones, wearable devices, and aerial robots. It is desirable to detect objects in the images using the on-board computers. Energy is limited in mobile systems so energy conservation is important. Low-Power Image Recognition Challenge (LPIRC) is the only competition integrating image recognition and low power. LPIRC has been held annually three times since 2015 as an on-site competitions.
Rewiring and Networking Language, Literacy, and Learning through the Arts: Developing Fluencies with Technology

In this chapter we present an ecological approach (Bronfenbrenner, 2007) to address the changing needs, opportunities, and challenges of teaching young children literacy in the 21st century. We provide examples to illustrate how technology works to develop fluencies that make learning meaningful for young children and their teachers. Implications for teacher education are offered.
‘Seeing the blessings and beauty of real estate: examining how market professionals’ lived space drives abstract space making’

This paper demonstrates the value of considering the lived experiences of abstract space makers as a way of exploring the micro-social and cultural dynamics buttressing capitalism’s domination over...
Clinical presentation and treatment of autoimmune encephalitis: single center cohort study of 47 cases. (P5.387)

Objective: In this retrospective cohort study, we aim to identify the distinctive clinical, laboratory and radiological presentation of autoimmune encephalitis and the response to treatment. Background: Autoimmune encephalitis are severe inflammatory disorders of central nervous system and diagnosis in clinical practice remains challenging despite recent advances in identification of new syndromes and autoantibodies. The diagnosis relies on the clinical manifestations, finding biomarkers and therapy response. However, this can be problematic given that antibody testing results are not readily available and negative testing does not exclude the diagnosis. Design/Methods: The study setting was a southeastern Michigan large health system. Electronic Medical Record was queried for diagnosis of autoimmune/paraneoplastic conditions using ICD 10 diagnostic code. Neurological symptoms, sociodemographic, laboratory, radiographic, treatment and outcomes data using modified Rankin scale (mRS) were collected. Two sample t-tests and Fisher’s exact tests were used. SAS version 9.4 was used for data analyses. Results: Of 47, 64% were female, 51% were white. The mean age at diagnosis was 56.9 years. The most common presentation was cognitive impairment (34%), followed by psychosis (30%). 69% had antibody to cell surface and 33% had normal MRI. 68% of 41 patients with mRS data had a mRS ≤ 2 and 32% had a mRS >2. Patients with mRS ≤ 2 were younger (p=0.046), less likely to have abnormal protein (p=0.031) or elevated IgG index (p=0.09), but higher rate of elevated WBC in CSF (p=0.097). PLEX treatment was less likely to be required for patients with mRS ≤ 2 (p=0.069). Steroid treatment was used in 62%, PLEX 28%, IVIG 19%. 23% remained on long term immunosuppression Conclusions: Autoimmune encephalitis is increasingly recognized as a heterogeneous group presenting with acute/subacute symptoms, but a diagnosis test is still yet to be found. Early recognition is important for this potentially treatable disorders as it may improve the prognosis. Disclosure: Dr. Affan has nothing to disclose. Dr. Madani has nothing to disclose. Dr. Osman has nothing to disclose. Dr. Alsrouji has nothing to disclose. Dr. Schultz has nothing to disclose. Dr. Cerghet has nothing to disclose.
CHARACTERISTICS AND TREATMENT PATTERNS OF PATIENTS WITH SEVERE TRICUSPID REGURGITATION CONSIDERED FOR INTERVENTION

This study aimed to identify characteristics, spectrum of TR severity, and treatment patterns in patients considered for intervention of severe, isolated TR at a tertiary center. The population being considered for TR intervention is currently not well defined and the role of transcatheter
Short communication: Phenotypic and genetic effects of the polled haplotype on yield, longevity, and fertility in US Brown Swiss, Holstein, and Jersey cattle

Phenotypes from the December 2018 US national genetic evaluations were used to compute effects of the polled haplotype in US Brown Swiss (BS), Holstein (HO), and Jersey (JE) cattle on milk, fat, and protein yields, somatic cell score, single-trait productive life, daughter pregnancy rate, heifer conception rate, and cow conception rate. Lactation records pre-adjusted for nongenetic factors and direct genomic values were used to estimate phenotypic and genetic effects of the polled haplotype, respectively. No phenotypic or direct genomic values effects were different from zero for any trait in any breed. Genomic PTA (gPTA) for the lifetime net merit (NM$) selection index of bulls born since January 1, 2012, that received a marketing code from the National Association of Animal Breeders (Madison, WI), and cows born on or after January 1, 2015, were compared to determine whether there was a systematic benefit to polled or horned genetics. Horned bulls had the highest average gPTA for NM$ in all 3 breeds, but that difference was significant only in HO and JE (HO: 615.4 ± 1.9, JE: 402.3 ± 3.4). Homozygous polled BS cows had significantly higher average gPTA for NM$ than their heterozygous polled or horned contemporaries (PP = 261.4 ± 43.5, Pp = 166.1 ± 13.7, pp = 174.1 ± 1.8), but the sample size was very small (n = 9). In HO and JE, horned cows had higher gPTA for NM$ (HO = 378.3 ± 0.2, JE = 283.3 ± 0.3). Selection for polled cattle should not have a detrimental effect on yield, fertility, or longevity, but these differences show that, in the short term, selection for polled over horned cattle will result in lower rates of genetic gain.
Stereotactic Body Radiation Therapy (SBRT) for Lung Metastases

Stereotactic body radiation therapy (SBRT) has emerged as a safe and effective option for ablation of well-localized primary and secondary lung tumors. Most published clinical trials and series of lung SBRT to date have been dose-escalation or single-arm studies, which collectively demonstrate local control rates exceeding 80% and a low incidence of high-grade toxicity. More recently, phase II randomized trials of consolidative locally ablative therapy in metastatic NSCLC, treating both intra- and extra-thoracic disease, have demonstrated improvements in progression-free survival and a reduction in new metastatic lesions. Concurrently, the rapidly evolving landscape of targeted agents and immunotherapeutics has led to an expanding role of SBRT in the treatment of oligoprogressive metastatic disease in an effort to extend access to effective, well-tolerated systemic therapies. As the role and survival impact of lung SBRT continues to be defined in various settings, careful patient selection and treatment delivery techniques remain paramount to maximizing the benefit of local tumor ablation in patients with metastatic disease.
Human trafficking – Multinational challenge for forensic science

Abstract Human trafficking is one of the fastest growing and profitable types of transnational crime. This form of modern-day slavery encompasses diverse practices of human exploitation such as sex trafficking, forced labor, marriage, begging, child soldiers, and illegal organ transplantation. The consequences of human trafficking affect all countries, are devastating for victims and society while impacting social, economic, and health costs. The project led by the University of North Texas Center for Human Identification (UNTCHI) is assisting Central American countries to identify the missing and address human trafficking by developing model legislation and policy, effective DNA forensic science capabilities and creating database systems. The focus for human identification is on at-risk individuals who are the most vulnerable part of society. This program engages the public and government to establish legislative models for DNA identification of missing persons that protect the privacy of individuals. The State of Texas recently provided support for UNTCHI to develop programs that address the human trafficking problem in Texas. The program will concentrate on training law enforcement agencies, healthcare professionals, students, and the public to recognize the signs of human trafficking and provide avenues of interdiction for victims. Additionally, as part of this effort a standalone humanitarian DNA database, which is established and managed by UNTCHI, has been implemented to enhance identification of missing persons, especially those who have crossed the border or may have been trafficked and died during their journey. As a standalone database, the system is not connected to the State DNA Index System (SDIS) or the National DNA Index System (NDIS) and thus not accessible by law enforcement. With this database, reference DNA profiles can be obtained from Central American countries and Mexico to identify human remains found in Texas while maintaining confidentiality and human rights. This work is an example of an effective means of transferring forensics, technology, and database practices, establishing policy and legislation, engaging the public, and developing strategies for sustainability for high incident countries. Ultimately the approach can promote a multinational exchange of DNA data to identify the missing.
Future Time Perspective in Mid-to-Later Life: The Role of Personality.

Objectives Future time perspective (FTP), or the way individuals orient to and consider their futures, is fundamental to motivation and well-being across the life span. There is a relative paucity of studies, however, that explore its contributing factors in mid-to-later life, specifically. Therefore, uncovering which variables contribute to individual differences in FTP, as well as the ways these variables interact, is paramount to developing a strong understanding of this construct during this life-span stage.
Oxidation of a c-Tb2O3(111) thin film by the sequential formation of stoichiometric phases

Abstract We used temperature-programmed desorption (TPD), low energy electron diffraction (LEED) and X-ray photoelectron spectroscopy (XPS) to investigate the oxidation of a well-ordered c-Tb2O3(111) thin film supported on Pt(111) by gaseous oxygen atoms in ultrahigh vacuum. Our results provide evidence that the c-Tb2O3 film oxidizes through the sequential development of the stoichiometric ι-Tb7O12 and δ-Tb11O20 phases, followed by the formation of a variable oxygen concentration α-TbOx phase up to x = 2. The ι and δ-phases decompose to yield sharp O2 TPD peaks at about 780 and 640 K, while the α-phase evolves O2 between ~450 and 600 K during TPD. Quantitative analysis shows that changes in the XPS Tb 3d and 4d spectra caused by oxidation agree well with our estimates of the TbOx film stoichiometry determined from TPD. We observe a well-defined LEED pattern for ι-Tb7O12(111) after heating the oxidized film to ~700 K. In contrast, several observations, including incomplete ι → δ conversion, lack of an observable LEED pattern for the δ-Tb11O20 phase, and sensitivity of α-phase formation to thermal aging of the film, indicate that the δ and α-phases develop under kinetic control for the conditions studied, such that the phases decompose in UHV at temperatures lower than those needed for these phases to stabilize into more crystalline and uniform arrangements.