cssi/SciSciGPT-SciSciNet huggingface dataset:
Exceptional superhydrophobicity and low velocity impact icephobicity of acetone-functionalized carbon nanotube films.

We present a simple method to produce carbon nanotube-based films with exceptional superhydrophobicity and impact icephobicity by depositing acetone-treated single-walled carbon nanotubes on glass substrates. This method is scalable and can be adopted for any substrate, both flexible and rigid. These films have indicated a high contact angle, in the vicinity of 170°, proved both by static and dynamic analysis processes. The dynamic evaporation studies indicated that a droplet deposited on the treated films evaporated in the constant contact angle mode for more than 80% of the total evaporation time, which is definitely a characteristic of superhydrophobic surfaces. Furthermore, the acetone-functionalized films showed a strong ability to mitigate ice accretion from supercooled water droplets (−8 °C), when the droplets were found to bounce off the films tilted at 30°. The untreated nanotube films did not indicate similar behavior, and the supercooled water droplets remained attached to the films’ surfaces. ...
Closed-Cycle Neon Refrigerator for High-Temperature Superconducting Magnets

A closed-cycle refrigerator using neon as a working fluid has been designed and is under construction at the Applied Superconductivity Center of the University of Wisconsin-Madison. The refrigerator is intended for use in testing small superconducting magnets formed from BSCCO and other high temperature superconducting materials. A hybrid design is used, with a helium cryocooler operating on the Gifford-McMahon cycle precooling a separate neon stream. The neon stream is driven by a rotary vane compressor that provides a flow rate of 0.4 g/s between high and low side pressures of 450 kPa and 50 kPa, respectively. The high and low sides are separated by a Joule-Thomson metering valve, which maintains low side pressure, and thus cold end temperature via a closed-loop PID controller. The refrigerator is designed to provide a cooling capacity of 10 Watts at 25 K. At the cold end, the neon will be partially condensed into a two-phase fluid which is transferred out of the refrigerator vessel to a separate magnet test vessel. The liquid fraction will be available for an isothermal convective interface with the magnet. This paper details the considerations and constraints that went into the design, and discusses the hardware chosen to perform the required processes. Special emphasis is placed on design and testing of the tube-in-tube and cable-in-conduit heat exchangers that have been built, or are presently being built for this project.
Improved virtual inertia based control of a grid connected voltage source converter with fault ride-through ability

This paper modifies the virtual inertia control of a grid connected converter and proposes a hybrid control technique to control a grid connected converter under grid unbalanced conditions. To limit fault currents and support fault ride-through, the control technique is changed from the virtual inertia control to the conventional current control during grid unbalances. With the mitigation of the grid unbalance the control is changed back to the virtual inertia control. The paper analyzes the advantages of doing so and introduces a control scheme to achieve the proposed transfer. Simulation results are presented to evaluate the proposed control.
Increased Mitochondrial Gene Deletions and ROS Production in Transgenic Mice Overexpressing a Human 8-Oxoguanine DNA-Glycosylase Gene: A Causal Association with the Development of Hematopoietic Neoplasms

Alterations of nuclear genes in human diseases including neoplasms have been well investigated in past several decades and unequivocally established their predominant role in the pathogenesis. However, the relationship of mitochondrial genome alteration with human diseases remains largely unknown. Mitochondria are dynamic organelles involved in oxidative phosphorylation and production of reactive oxygen species (ROS). Accumulated evidence supports that mitochondrial DNA damage and dysfunction play vital roles in the development of a wide array of mitochondria-related human diseases, such as obesity, diabetes, infertility, neurodegenerative disorders and malignant tumors. We previously described the development of a transgenic (TG) mouse model for mitochondrial DNA damage by overexpressing human mitochondrial isoform of 8-oxoguanine DNA Glycosylase 1 (hOGG1) gene. Over-expression of this gene produced a wide range of adverse biological phenotypes, manifesting early-onset obesity, metabolic disturbance, female infertility, high frequency of B-cell lymphoma and human essential thrombocythemia like myeloproliferative disorder, involving the lymph node, bone marrow, spleen, liver and other extranodal sites. Development of these hematopoietic neoplasms appeared to be age-dependent. In the current study, we focused on the pathogenesis of the hematopoietic neoplasms by characterization of the neoplasms via pathologic, biochemical and molecular approaches. While expression of mOGG1 was very similar in parallel organs from transgenic and wild-type control mice, the hOGG1 TG mice expressed very high levels of human OGG1 transgene mRNA, being 6.8- and 112-fold as high as the endogenous mouse OGG, in the spleen and bone marrow. By contrast, hOGG1 transgene mRNA were not detected at all in the above two organs from control mice, indicating that the transgene is highly expressed in the hematopoietic organs in TG mice. We then measured mitochondrial NADH dehydrogenase 1 (ND1) gene expression as an indirect measure of mitochondrial respiratory function. ND1 mRNA levels in the spleen (4) and lymphoma (4) of TG mice were 83% and 58% higher, respectively, than those in the spleen (4) of wild-type control mice (P 2 O 2 production in the lymphoma and spleen of hOGG1 transgenic (4) and the spleen from wild-type control (4) mice. The amount of H 2 O 2 produced in the lymphoma and the spleen of hOGG1 transgenic mice was ~166% and ~66% higher, respectively, than that in the spleen from wild-type control mice (P 2 O 2 produced in the lymphoma was ~60% higher than that in the spleen from hOGG1 transgenic mice (P Disclosures No relevant conflicts of interest to declare.
Network-assisted target identification for haploinsufficiency and homozygous profiling screens

Chemical genomic screens have recently emerged as a systematic approach to drug discovery on a genome-wide scale. Drug target identification and elucidation of the mechanism of action (MoA) of hits from these noisy high-throughput screens remain difficult. Here, we present GIT (Genetic Interaction Network-Assisted Target Identification), a network analysis method for drug target identification in haploinsufficiency profiling (HIP) and homozygous profiling (HOP) screens. With the drug-induced phenotypic fitness defect of the deletion of a gene, GIT also incorporates the fitness defects of the gene's neighbors in the genetic interaction network. On three genome-scale yeast chemical genomic screens, GIT substantially outperforms previous scoring methods on target identification on HIP and HOP assays, respectively. Finally, we showed that by combining HIP and HOP assays, GIT further boosts target identification and reveals potential drug's mechanism of action.
Mass Spectrometric Analysis of SOX11-Binding Proteins in Head and Neck Cancer Cells Demonstrates the Interaction of SOX11 and HSP90α

Deregulated expression of SOX11 has been shown to be involved in the progression of various types of cancer. However, the role of SOX11 in head and neck cancer remains largely unknown. In this study, coimmunoprecipitation (Co-IP) and liquid chromatography–tandem mass spectrometry (LC–MS/MS) were performed to identify the proteins that bind to SOX11 at significantly higher levels in head and neck cancer cells than in normal human oral keratinocytes. Gene Ontology and Kyoto Encyclopedia of Genes and Genomes (KEGG) pathway analyses indicated that many potential SOX11-binding partners were associated with protein synthesis, cell metabolism, and cell–cell adhesion. One of the identified proteins, heat shock protein 90 alpha (HSP90α), was selected for further investigation. The binding of HSP90α with SOX11 in head and neck cancer cells was validated by Co-IP with western blotting. In addition, HSP90α was found to be remarkably overexpressed in head and neck cancer cell lines when compared to its level in normal...
Student congruence with academic major: Do hours worked and attitude affect satisfaction and success?:

The current study sought to determine if student employment was a significant moderator of the relationship between congruence with college major, academic major satisfaction, and academic major success. Correlation results suggested that student employment has a negative relationship with academic success as measured by grade point average. No study hypotheses were supported but regression analyses showed significant impact of cognitive influences on academic major satisfaction and academic major success. Clinicians are encouraged to aid students in planning the relationship between required work and educational responsibilities, as well as consider implications of negative career thinking on academic satisfaction and success.
Proteasome Inhibitors with a Focus on Bortezomib

Proteasome inhibitors have changed the treatment landscape for multiple myeloma and are being increasingly used in the treatment of lymphoma; however, patients eventually have progressive disease and development resistance to treatment. Multiple unique mechanisms of resistance have been identified, and they are unified by reducing a cell’s sensitivity to endoplasmic reticulum stress either from changes intrinsic to the cancer cell or extrinsic to the cancer cell and due to changes in the microenvironment. These pathways primarily involve upregulation of proteasome subunits increasing the capacity to degrade unfolded proteins and plasmacytic differentiation to a more immature plasma cell phenotype with reduced immunoglobulin production. Understanding these mechanisms of resistance can inform therapeutic options to reverse drug resistance or use of novel combinations to synergistically target the unfolded protein response pathway.
THE EFFECT OF NETWORK POSITION ON CAPILLARY HEMODYNAMICS

ABSTRACT Capillaries have often been considered, by both modelers and experimentalists, to be more-or-less identical with respect to their hemodynamic behavior. However it is apparent that at the capillary level the flow through any vessel is dependent not only on that vessels characteristics but also on the position of the vessel in the capillary network. In addition the ability of a capillary vessel to control its own flow is dependent on the vessels ability to control not only its own resistance but also on the specific network geometry and vessel location. These observations have important implications with respect to the concept of additivity of the resistance of vessels at various anatomical levels and with respect to overall understanding of microcirculatory function and control. There are also implications for experimentalists who study individual capillary pressures, flows and transport without reference to the location of the test vessel in a capillary vessel.
TEMPERATURE-DEPENDENT VIBRATIONAL DYNAMICS AND INHOMOGENEOUS BROADENING IN GLASS-FORMING LIQUIDS STUDIED WITH INFRARED PHOTON ECHOES

Picosecond infrared (IR) photon echo and pump-probe experiments have been used for a detailed study of the temperature-dependence of the homogeneous vibrational lineshape and inhomogeneous broadening of a high-frequency vibrational transition in three molecular glass-forming liquids−1. The homogeneous vibrational linewidth of the Tlu CO stretch of tungsten hexacarbonyl (∼1980 cm−1) was measured in 2-methylpentane (2-MP), 2-methyltetrahydrofuran (2-MTHF), and dibutylphthalate (DBP) from 300 K to 10 K. The dynamics cover temperature regions from the glass, through the glass transition and supercooled liquid, to the room temperature liquid. These experiments are the first to directly follow the temperature-dependent vibrational dynamics in amorphous condensed phases, and quantify the degree of inhomogeneous broadening for these systems.
Expression of embryonic globins by erythroid cells in juvenile chronic myelocytic leukemia

Juvenile chronic myelocytic leukemia (JCML) is a rare hematopoietic neoplasia of early childhood with distinct hematologic and biochemical features. We studied the biologic properties and the globin synthetic profiles of JCML erythroid cells both in vivo and in vitro from a total of 24 patients. In these cases we observed the exuberant colony-forming unit-macrophage (CFU-M) colony growth, as reported previously. Furthermore, in contrast to previous reports, we found significant erythroid colony growth in most of our cases (average: 1,182 burst- forming unit-erythroid [BFUe] per 10(5) plated cells, range: 40 to 6,927). This growth was by and large erythropoietin-dependent and was not greatly influenced by other added cytokines. By several criteria all erythroid colony growth detected in vitro was derived from JCML progenitors. The globin synthetic profile of JCML erythroid cells showed high levels of fetal hemoglobin both in vivo and in vitro (gamma/gamma + beta: 53% to 94% in reticulocytes, 62% to 98% in BFUe- derived cells). In addition (in seven cases studied) we detected embryonic globins (epsilon and zeta) at the protein and messenger RNA level, a novel finding for primary leukemic cells. We speculate that the transformed erythroid cells in JCML harbor a trans environment supporting expression of developmentally earlier genes (fetal, embryonic). However, in contrast to other acute or subacute leukemias, JCML erythroid cells also have the ability to reach full maturation to the red cell level, thus allowing detection of this primitive program in vivo.
Comparing the effects of organic, natural, and no additives labels on tobacco packaging between Lesbian, Gay, Bisexual (LGB) and heterosexual smokers.

Abstract Introduction Previous research found that exposure to health-oriented language (e.g., natural, organic) on tobacco product packages is associated with reduced perceptions of harm and intention to purchase the product. However, how lesbian, gay, bisexual (LGB) individuals, who use tobacco products at a higher rate than heterosexual peers, respond to health-oriented labels has not yet been examined. This analysis examines whether responses to health-oriented labels differ between LGB persons and heterosexual individuals. Methods Secondary analysis was completed from an experimental study that exposed US adult smokers to a non-US cigarette (Study 1) or e-cigarette (Study 2) package that displayed either health-oriented language (‘100% organic,’ ‘all natural’ or ‘no additives’), traditional marketing language (‘fine quality,’ ‘premium blend’ or ‘100% original’) or no language. Results No significant differences were found between LGB smokers and heterosexual smokers in responses to cigarette packages with health-oriented labels (Study 1). However, LGB smokers had less favorable attitudes toward the e-cigarette product after viewing health-oriented labels (versus no language control label) while heterosexual smokers' attitudes did not differ across health-oriented and control labels (Study 2). In addition, LGB smokers had lower intention to purchase and vape e-cigarettes, and less favorable attitudes in response to health-oriented labels than heterosexual smokers. Conclusions Findings suggest that LGB smokers process pro-tobacco messages differently than heterosexual smokers, and that product type (i.e., cigarette vs. e-cigarette) may be a factor to consider. Further research is needed to uncover underlying mechanisms.
Colombia 2017: entre la implementación y la incertidumbre

Este articulo repasa los hechos mas importantes del ano en Colombia, principal­mente la implementacion del Acuerdo de Paz firmado entre el presidente Juan Ma­nuel Santos y las Fuerzas Armadas Revolucionarias de Colombia (FARC) en 2016. La primera parte del articulo hace un balance de la implementacion. La segunda parte repasa los principales indicadores economicos y algunos hechos que impac­taron la economia nacional. La tercera y cuarta parte discuten las transformaciones del Gabinete Ministerial y la produccion legislativa, respectivamente. La quinta parte discute la relacion bilateral de Colombia con Estados Unidos y las consecuen­cias de la crisis Venezolana. La ultima seccion ofrece algunas reflexiones sobre los temas que impactaran al nuevo gobierno colombiano.
The role of percutaneous vacuum‐assisted thrombectomy for intracardiac and intravascular pathology

Vacuum-assisted thrombectomy (VAT) is a mechanical suction device that can be deployed to aspirate thrombi in the heart and vascular system. Successful percutaneous aspiration of iliocaval, right heart, and pulmonary arterial thrombi have been reported, in addition to the debulking of intravascular and intracardiac masses and vegetations. VAT is indicated for patients who are poor surgical candidates and/or have a contraindication to thrombolysis. This review discusses the mechanism, current results, potential clinical indications, and limitations of VAT for iliocaval and intracardiac mass removal.
Quantifying cold front induced water transport of a bay with in situ observations using manned and unmanned boats

The generation of high-resolution data is increasingly important in understanding the complexities of coastal ocean and developing sound management strategies, especially in view of the long-term impact of severe weather systems. The impact of severe weather systems, when integrated over time, can be significant when compared with tidal oscillations. This paper presents a study of water transport out of Vermilion Bay in response to a short, intense event associated with a passing atmospheric cold front, and reports the application of an Acoustic Doppler Current Profiler (ADCP) mounted on an Automated Surface Craft (ASC), known as the auto-boat or unmanned boat, developed in our lab at the Louisiana State University, to generate high resolution data accurately at a fraction of the cost of a manned boat. In our study, we used a manned boat and an unmanned boat, each for over 24 h to cover an entire diurnal tidal cycle, to measure flow velocity profiles to calculate the total transport. A stationary ADCP was deployed in the Southwest Pass of the Vermilion Bay from May 2009 to April 2012, providing data almost continuously (with only one major gap), with a 717-day record of water transport between the northern Gulf of Mexico and Vermilion Bay, and demonstrates the importance of the pass in water transport.
Computational Analysis of Environmental Control System of an Aircraft Using Dry and Moist Air as Medium

For a fighter aircraft to operate effectively in severe weather conditions, an efficient and effective Environmental Control System (ECS) is one of the basic requirements. Accurate working of electronic equipment installed in cockpit and comfort of pilot require temperature, pressure and humidity levels inside the cockpit to be well within limits as defined in the Mil standard MIL-E-18927E(AS). In this paper, computational analysis of cockpit Environmental Control System (ECS) of a fighter aircraft for a designed (dry air) and an off designed condition (moist air) is presented. Certain flight conditions which are defined in the aircraft flight envelope are used to design an effective ECS of the understudy aircraft to ensure comfortable temperature environment for the pilot and electronic equipment. To validate ECS performance, analysis at the most severe environmental conditions (International Standard Atmosphere + 30°C while flying at 0.825 Mach Number at sea level) has been considered. Complete analysis of flow and temperature field inside the cockpit has been performed in FLUENT® for performance verification. In the first analysis, dry air properties have been used as per design. This is possible due to availability of water separator in the system design which removes most of the water vapors in the cold air coming from the cooling turbine before entering the cockpit. In addition, an analysis of ECS performance for an off design condition by assuming saturation/failure of water separator which results into provisioning of moist air in the cockpit has also been presented. ECS performance under both the conditions has been thoroughly evaluated with respect to MIL standard MIL-E-18927E(AS) and the results have been found satisfactory. It has been demonstrated that CFD techniques can be used to analyze the flow and temperature field inside the cockpit of an aircraft.
The Utility and Survivorship of Peripheral Intravenous Catheters Inserted in the Emergency Department.

Study objective We compare the use and survivorship rate of peripheral intravenous catheters placed in the emergency department (ED) by insertion method. Methods We analyzed a prospective cohort of ED patients who received a peripheral intravenous catheter in the ED by ultrasonographically guided or landmark insertion. Research assistants recorded the uses of the ED-inserted catheters during the ED visit and hospitalization. Among subjects admitted, research assistants tracked catheter survivorship for 72 hours or hospital discharge, whichever came first. Research assistants documented reason for catheter removal and whether it was replaced during hospitalization. Premature removal was defined as catheters that were replaced because of mechanical failure, complication, or discomfort. We used multivariate binomial regression to estimate the relative risk of insertion method on premature removal and a Kaplan-Meier curve to compare survivorship duration by insertion method. Results A cohort of 1,174 patients with a mean age of 45 years and 63% female predominance was analyzed. Catheter use was 73% and 78% in the ED and hospital for the administration of fluids, medications, or contrast agents (and 96% if blood drawn for testing was included). Peripheral intravenous use did not differ significantly in the ED or hospital by insertion method. For 330 patients who were admitted, 132 of 182 patients (73%) in the ultrasonographically guided group and 117 of 148 (79%) in the landmark group had 72-hour catheter survival. Premature removal was not significantly more likely to occur if the catheter was inserted by the ultrasonographically guided method compared with the landmark one (relative risk 1.26; 95% confidence interval 0.88 to 1.80). Conclusion ED-inserted peripheral intravenous catheters were frequently used in the ED and hospital. Peripheral intravenous use and hospital survivorship of ED-inserted peripheral intravenous catheters were similar by insertion method.
KNIEST SYNDROME: CASE REPORT AND REVIEW OF LITERATURE

Background Kniest syndrome (dysplasia) is a rare autosomal dominant chondrodysplasia that is characterized by distinct musculoskeletal and craniofacial irregularities. These abnormalities result from a mutation of the collagen type II gene (COL2A1) resulting in an abnormal type II collagen product. Craniofacial abnormalities seen in this syndrome include prominent eyes, flat nasal bridge, cleft palate, midface anomalies, tracheomalacia, and hearing loss. This report illustrates a case of Kniest syndrome with severe dentoskeletal malformation with cleft palate treated at Eastman Institute for Oral Health. In addition, the report also outlines clinical, histopathological and radiographic findings of the condition with a review of literature of Kniest syndrome. Method Case study of a 16 year old male with a history of Kniest syndrome presented to the Orthodontic clinic seeking treatment for misaligned teeth. The patient showed clinical features of this syndrome which included dwarfism, severe midface hypoplasia, flattened and rounded face with prominent eyes and nasal atresia. Patient had a history of cleft palate repair. Intraoral findings included severe gingival hyperplasia, high arched palate and abnormal dentoalveolar development. Conclusion Kniest syndrome (dysplasia) is a rare chondrodysplasia with differential diagnosis that can include Spondy-loepiphyseal dysplasia, Spondyloepimetaphyseal and Metatropic dwarfism. In addition to genetic testing, distinct radiographic features and histopathological studies are crucial in determining the proper diagnosis of the condition.
Prostate Contrast Enhanced Transrectal Ultrasound Evaluation of the Prostate With Whole-Mount Prostatectomy Correlation.

Abstract Objective To investigate the diagnostic accuracy of contrast enhanced transrectal ultrasound (CE-TRUS) in comparison with whole-mount radical prostatectomy specimens. Method and Materials Fifty-eight subjects who underwent CE-TRUS and subsequent radical prostatectomy with whole-mount pathology were included in the study. Each patient underwent evaluation with baseline TRUS and again during CE-TRUS with intravenous infusion of perflutren lipid microsphere (Definity, Lantheus Medical Imaging, N Billerica, MA). A subjective 5 point scale was used to rate each sextant of the prostate in 3 baseline imaging modes and in 5 contrast-enhanced imaging modes. Baseline TRUS and CE-TRUS findings were compared with digitized whole-mount findings. A clustered logistic regression model was computed to compare the area under the receiver operating characteristic curve (Az) for detection of prostate cancer by various modes of ultrasound imaging. Results Among the 58 whole-mount specimens, a maximum Gleason score of 6 was identified in 29 subjects, a score of 7 was identified in 24 and a score of 8 was identified in 5. The Az for baseline TRUS parameters was 0.55 for grayscale, 0.61 for color Doppler and 0.59 for power Doppler. CE-TRUS parameters demonstrated significant increases in Az with the highest Az for CE-power Doppler (0.66) and flash replenishment imaging (0.64) (P = .04 for comparison to baseline). The combination of CE-power Doppler and flash replenishment imaging resulted in improved Az compared with baseline imaging (0.70 vs 0.59, P= .006). Conclusion Contrast-enhanced ultrasonography demonstrates greater diagnostic accuracy than baseline imaging. Diagnostic accuracy is further improved for "clinically significant" tumor volumes >1 cc.
Understanding the Impact of Dynamic Power Capping on Application Progress

Electrical power has become an important design constraint in high-performance computing (HPC) systems. On future HPC machines, power is likely to be a budgeted resource and thus managed dynamically. Power management software needs to reliably measure application performance at runtime in order to respond effectively to changes in application behavior. Execution time tells us little about how the science in the application is progressing toward an application-defined end goal. To the best of our knowledge, no study has defined or categorized online application progress in the context of power management. Based on semi-structured interviews with HPC application-specialists, we define an online notion of progress—an application-specific metric that can be monitored at runtime to provide a sense of the rate at which application science is being performed. Using instrumentation, we characterize and categorize the progress of various production scientific applications and benchmarks. We propose a model of the impact of dynamic power capping on application progress. By experimental evaluation, we show that our model accurately captures the general behavior of the progress of different classes of applications under a power cap. We believe that such a model is an important first step toward the design of more dynamic power management policies for HPC systems.
The symptom experience of adolescents with concussion

PURPOSE The incidence of concussions in adolescents has increased in recent years. Concussion causes an array of symptoms that can interfere with the daily life of an adolescent, yet the symptoms and recovery vary greatly. Concussion management is based on expert consensus guidelines but they are not specific for adolescents and it is unclear how adolescents actually manage their symptoms. This study aimed to describe the symptom experience of adolescents with a concussion and their self-management strategies. DESIGN AND METHODS The study used a qualitative design to explore the symptom experiences of adolescents. Ten adolescents aged 14-17 years were recruited from a concussion clinic. Using a semi-structured interview, adolescents were asked about their concussion symptoms, the interference with their daily life, and their symptom self-management strategies. Data were analyzed using descriptive statistics and content analysis. RESULTS Adolescents reported 17 different symptoms they experienced following their concussion. All of the adolescents reported a headache but descriptions varied. The symptoms interfered with many aspects of their daily life including school and activities. The majority of the school responses were related to difficulties attending school and learning (n = 21). The self-management strategies were organized into 11 categories. The most common strategies fell under three categories: rest (n = 20), controlling the environment (n = 20), and using motivational thoughts and activities (n = 9). PRACTICE IMPLICATIONS This study indicates that adolescents experience multiple symptoms after their concussion and use a variety of strategies to manage the symptoms. Each adolescent had a unique symptom experience, highlighting the need for developing personalized concussion management plans. Nurses can coordinate the development of management plans and provide education about managing concussion symptoms and promoting recovery.
THE STUDY ON RECOGNIZING OOLID RESERVOIR FROM WELL LOGGING INFORMATION

Based on well logging response characteristic of oolid reservoir and electrical- lithologic database from log parameters of lithology, automatic classifying formation is realized. By gray conjunction method, oolid formation of each well profile is identified and the log recognition pattern for oolid reservoir is established by combining reservoir parameters and then the programs is developed. The application shows that this method has higher resolution and is able to classify oolid reservoirs of thicker than 0.5 meter and improves the prediction precision in vertical and horizontal direction.
Should Poor Social Support Be an Exclusion Criterion in Bone Marrow Transplantation

At some point in their careers, many medical providers will have to decide whether to offer a patient a therapeutic intervention that is medically and resource intensive. The stakes are particularl...
The structure and function of intercellular junctions in cancer.

Publisher Summary Intercellular junctions are a set of structurally complex membrane components that are incorporated into the general plasma membrane at the sites of close cell-to-cell apposition. The primary function of some types of junctions, such as gap junctions, remains obscure; this is unfortunate because a considerable body of information on the occurrence, biochemical ultrastructure, and physical properties of junctions suggests that they probably do play a central role in important biological phenomena. The quantitative evaluations of the occurrence of junctions are subjective in most of the reports, although there are a few reports in which the data were obtained by quantitative electron microscopy techniques. There are a number of ways in which genes of neoplastic transformation may influence intercellular junction structure and function. Additional research is required to define the contribution of tumor gene products to the pathogenesis of junctional abnormalities in tumors and to elucidate the roles, if any, of these cell membrane defects in malignant growth.
Pain scales as placebos: Can pain scales change reported pain across measurements?

Abstract Various aspects of measurement scales, such as whether the scale is unipolar or bipolar, or the direction of response alternatives, can influence how people evaluate their own subjective experience. Here, we demonstrate scale effects tied to repeated measurement by examining self-reported pain. In many contexts, assessment of subjective experiences is done repeatedly, as when pain patients report their pain levels using a variety of scales. We propose that this repeated measurement can impact how people report their pain. In two studies, we find that the choice of measurement scale initially used to assess pain results in different levels of self-reported pain levels at a later assessment. These repeated scale measurement effects appear to be due, in part, to the initial scales differentially affecting participant expectations for the amount of additional pain they can bear. This work extends literature on scale effects to repeated measurement. Given that many subjective experiences besides pain are also measured repeatedly (e.g., fatigue and anxiety), our results also may have wider application to other domains of experience.
The Impact of Previsit Contextual Data Collection on Patient-Provider Communication and Patient Activation: Study Protocol for a Randomized Controlled Trial.

Background: Patient-centered care is respectful of and responsive to individual patient preferences, needs, and values. To provide patient-centered care, clinicians need to know and incorporate patients’ context into their communication and care with patients. Patient contextual data (PCD) encompass social determinants of health and patients’ needs, values, goals, and preferences relevant to their care. PCD can be challenging to collect as a routine component of the time-limited primary care visit. Objective: This study aims to determine if patient-provider communication and patient activation are different for patient users and patient nonusers of an electronic health record (EHR)–integrated PCD tool and assess if the impact of using PCD on patient-provider communication and patient activation differs for Black and White patients. Methods: We describe a randomized controlled trial of a prospective cohort of non-Hispanic White and Black patients who receive primary care services at a midwestern academic health care system in the United States. We will evaluate whether providing PCD through a consumer informatics tool enhances patient-provider communication, as measured by the Communication Assessment Tool, and we will evaluate patient activation, as measured by the Patient Activation Measure for PCD tool users and nonusers. Furthermore, owing to racial disparities in care and communication, we seek to determine if the adoption and use of the tool might narrow the differences between patient groups. Results: The trial was funded in November 2017 and received local ethics review approval in February 2019. The study began recruitment in April 2019 and enrollment concluded in October 2019 with 301 participants. The analysis was completed in May 2020, and trial results are expected to be published in winter 2020. Conclusions: Recently, there has been increased attention to the role of health information technology tools to enable patients to collaborate with providers through the sharing of PCD. The adoption of such tools may overcome the barriers of current EHRs by directly engaging patients to submit their contextual data. Effectively, these tools would support the EHR in providing a more holistic understanding of the patient. Research further supports that individuals who have robust digital engagement using consumer informatics tools have higher participation in treatment follow-up and self-care across populations. Therefore, it is critical to investigate interventions that elicit and share patients’ social risks and care preferences with the health care team as a mechanism to improve individualized care and reduce the gap in health outcomes. Clinical Trial: ClinicalTrials.gov NCT03766841; https://clinicaltrials.gov/ct2/show/NCT03766841
Worry and e-cigarette cognition: The moderating role of sex.

Abstract As electronic cigarette (e-cigarette) use continues to rise, it is important to identify individual characteristics that may influence e-cigarette use behavior and potential group-level moderators of effects, such as sex. Initial evidence has suggested that worry, defined as excessive, unrealistic thoughts focused on the possibility of future negative events, may contribute to e-cigarette use behavior. Yet, how these established relations differ across groups, such as male and female e-cigarette users, has not been explored. The present study evaluated the effect of worry on perceived barriers for quitting e-cigarettes, perceptions of benefits for e-cigarette use, and perceived negative consequences of e-cigarette use across sex. The sample included 584 current e-cigarette users (52.2% female, Mage = 35.15 years, SD = 10.27). Analyses indicated a significant interaction between sex and worry on each criterion variable (perceived benefits: b = 0.02, SE = 0.01, t = −2.73, p = .01; perceived barriers for quitting e-cigarettes: b = −0.45, SE = 0.08, t = −5.70, p ≤ 0.001; negative consequences to use: b = −0.033, SE = 0.01, t = −4.50, p
Changing the channel on medical ethics education: systematic review and qualitative analysis of didactic-icebreakers in medical ethics and professionalism teaching.

As medical ethics and professionalism education continues to equip medical students and residents with long-lasting tools, educators should continue to supplement proven teaching strategies with engaging, relatable, and generationally appropriate didactic supplements. However, popular teaching aids have recently been criticized in the literature and summative information on alternatives is absent. The purpose of this review is to evaluate and assess the functional use and application of short form audiovisual didactic supplements or "icebreakers" in medical ethics and professionalism teaching. A systematic review of both the medical and humanities literature (i.e., PubMed/MEDLINE, Cochrane Library, and JSTOR) was conducted from inception to August 1, 2019. Final articles were subjected to a qualitative appraisal and thematic analysis. Thirteen articles were included for final analysis. Sixty-nine percent (n = 9) of the studies were published after 2000. Two studies were qualitative, one study was quantitative, and the remaining articles were commentaries. Short form audiovisual media was most popular outside of the United States (n = 10). Sixty-nine percent (n = 9) of articles advocated for self-contained media in the form of trigger films or short films/videos, while the remaining articles (n = 4) discussed the use of TV/film clips. Producibility of media was exclusive to short/trigger films. Nine themes were identified in the content analysis: adaptability, conversation catalyst, effective, engaging, nuance, practice, producibility, real, and subject diversity. The three most common themes in descending order of frequency were: conversation catalyst, realness, and adaptability. Trigger films represent an effective and unique pedagogical strategy in supplementing current medical ethics and professionalism teaching at the medical school level.
Acquisitions as Exaptation: The Legacy of Founding Institutions in the US Commercial Banking Industry

This study focuses on how founding institutions impact intraorganizational capabilities and how such imprints may have different external manifestations in subsequent historical eras. We introduce the concept of exaptation to organizational theory, identifying an important process whereby the historical origin of a capability differs from its current usefulness. Three founding conditions — branching policy, modernization, and political culture — influenced banks’ development of capabilities for managing dispersed branches, and these capabilities subsequently led to variation in banks’ propensity to engage in acquisitions.
Intraoperative thalamocortical tract monitoring via direct cortical recordings during craniotomy.

Abstract Objective Neuromonitoring of primary motor regions allows preservation of motor strength and is frequently employed during cranial procedures. Less is known about protection of sensory function and ability to modulate movements, both of which rely on integrity of thalamocortical afferents (TCA) to fronto-parietal regions. We describe our experience with TCA monitoring and their cortical relays during brain tumor surgery. Methodology To study its feasibility and usefulness, continuous somatosensory evoked potentials (SSEP) recording via a subdural electrode was attempted in 32 consecutive patients. Results Median and posterior tibial SSEP were successfully monitored in 31 and 17 patients respectively. SSEP improved lesion localization and prevented unnecessary cortical stimulation in 9 and 16 cases respectively. A threshold of ≥30% SSEP amplitude decrease influenced management in 10 patients while a decrement of ≥50 % had a sensitivity of 0.89 and specificity of 1 in detecting worsening of sensory function. Simultaneous motor evoked potentials (MEP) and SSEP monitoring were performed in 10 cases, 9 of which showed short-lived fluctuations of the former. Conclusion Direct cortical SSEP monitoring is feasible, informs management and predicts outcome. Significance Early intervention prevents sensory deficit. Concomitant MEP fluctuations may reflect modulation of motor activity by TCA.
Racial differences in the treatment and outcomes for prostate cancer in Massachusetts

Background Massachusetts is a northeastern state with universally mandated health insurance since 2006. Although Black men have generally worse prostate cancer outcomes, emerging data suggest that they may experience equivalent outcomes within a fully insured system. In this setting, the authors analyzed treatments and outcomes of non-Hispanic White and Black men in Massachusetts. Methods White and Black men who were 20 years old or older and had been diagnosed with localized intermediate- or high-risk nonmetastatic prostate cancer in 2004-2015 were identified in the Massachusetts Cancer Registry. Adjusted logistic regression models were used to assess predictors of definitive therapy. Adjusted and unadjusted survival models compared cancer-specific mortality. Interaction terms were then used to assess whether the effect of race varied between counties. Results A total of 20,856 men were identified. Of these, 19,287 (92.5%) were White. There were significant county-level differences in the odds of receiving definitive therapy and survival. Survival was worse for those with high-risk cancer (adjusted hazard ratio [HR], 1.50; 95% CI, 1.4-1.60) and those with public insurance (adjusted HR for Medicaid, 1.69; 95% CI, 1.38-2.07; adjusted HR for Medicare, 1.2; 95% CI, 1.14-1.35). Black men were less likely to receive definitive therapy (adjusted odds ratio, 0.78; 95% CI, 0.74-0.83) but had a 17% lower cancer-specific mortality (adjusted HR, 0.83; 95% CI, 0.7-0.99). Conclusions Despite lower odds of definitive treatment, Black men experience decreased cancer-specific mortality in comparison with White men in Massachusetts. These data support the growing body of research showing that Black men may achieve outcomes equivalent to or even better than those of White men within the context of a well-insured population. Lay summary There is a growing body of evidence showing that the excess risk of death among Black men with prostate cancer may be caused by disparities in access to care, with few or no disparities seen in universally insured health systems such as the Veterans Affairs and US Military Health System. Therefore, the authors sought to assess racial disparities in prostate cancer in Massachusetts, which was the earliest US state to mandate universal insurance coverage (in 2006). Despite lower odds of definitive treatment, Black men with prostate cancer experience reduced cancer-specific mortality in comparison with White men in Massachusetts. These data support the growing body of research showing that Black men may achieve outcomes equivalent to or even better than those of White men within the context of a well-insured population.
Best practices and tools for reporting reproducible fluorescence microscopy methods.

Although fluorescence microscopy is ubiquitous in biomedical research, microscopy methods reporting is inconsistent and perhaps undervalued. We emphasize the importance of appropriate microscopy methods reporting and seek to educate researchers about how microscopy metadata impact data interpretation. We provide comprehensive guidelines and resources to enable accurate reporting for the most common fluorescence light microscopy modalities. We aim to improve microscopy reporting, thus improving the quality, rigor and reproducibility of image-based science. Comprehensive guidelines and resources to enable accurate reporting for the most common fluorescence light microscopy modalities are reported with the goal of improving microscopy reporting, rigor and reproducibility.
An Intersectional Approach to Studying Burnout in Local Government

This paper empirically examines the simultaneous influence of multiple dimensions of individual identity on employee burnout. We advance a better understanding of disparities in individual well-bei...
Earth Science Week to make a splash

Abstract Geoscientists have important roles in the management of the world's water at local, regional, national, and global scales. Geophysical information is critical to ensure that people have en...
Common seasonal respiratory viral infections in children before and during the coronavirus disease 2019 (COVID-19) pandemic.

Objectives To describe the incidence of seasonal respiratory viral infections (s-RVIs) before and during the coronavirus disease 2019 (COVID-19) pandemic and to compare virus-specific patient outcomes in pediatric patients. Design A retrospective cross-sectional study including patient admissions to the Children's National Hospital between October 1, 2015, and December 31, 2020. Results Among 12,451 patient admissions between March 15 and December 31, 2020 (cohort 1), 8,162 (66%) were tested for severe acute respiratory coronavirus virus 2 (SARS-CoV-2), and 249 (2.0%) were positive. Among 10,986 patient admissions between April 1 and December 31, 2020 (cohort 2), 844 (8%) were tested for s-RV upon admission and 160 were positive. Thus, 1.5% of patient admissions were associated with laboratory-confirmed s-RVIs. Among the 49,901 patient admissions during a viral season between October 1, 2015, and March 31, 2020 (cohort 3), 7,539 (15%) were tested for s-RV upon admission and 4,531 were positive; thus, 9.0% of patient admissions were associated with laboratory-confirmed s-RVIs. hHRV/rENT was the most detected virus, but the detection rate decreased substantially (31% vs 18%; P .05) or death at discharge (0.8% vs 0.6% vs 0.5%; P > .05). Conclusions Compared to COVID-19, s-RVI cases were associated with a higher proportion of inpatient admissions but were similar in ICU admission and death rates in hospitalized pediatric patients. Public health interventions for preventing COVID-19 were highly effective in preventing pediatrics s-RVIs.
Integrating lifelong learning into a feedback controls course

Lifelong learning is being featured as a detailed application of the technical content of a senior feedback controls course required for electrical, computer and mechanical engineering students. Related course objectives are: (1) to motivate engineering students before graduation to pursue lifelong learning throughout their careers; and (2) to use feedback control concepts to enhance the importance of lifelong learning. Results are reported for a class of 46 students during the spring 1999 semester at the University of Kansas, USA.