cssi/SciSciGPT-SciSciNet huggingface dataset:
The Product Management Audit: Design and Survey Findings

In many companies, product managers are under increasing time pressure. They are generalists in a marketing world that is increasingly specialized and complex. There are more tasks to perform, more specialist skills to acquire, more fires to fight, and less time for thinking and strategic planning. If their general management skills are to be used effectively, product managers must be able to focus their time on the tasks that exploit these skills and help their businesses to grow. The product management audit surveys product managers on how they actually spend their time and how they would ideally spend it to really build their businesses. Data from the audit can help to establish time allocation priorities for product managers and uncover potential time allocation problems before they become critical. We will first review the changes in the marketing environment that are putting pressure on the product management system. Second, we will show how any consumer, industrial, or service company can conduct a product management audit to find out how product management personnel are spending their time and why, and how satisfied they are with their jobs, the support provided, and rewards they are receiving. Third, we will illustrate the type of data that the audit can generate and present key findings from responses to audit surveys by over 300 product management personnel from 20 strategic business units in six Fortune 500 consumer goods companies. Finally, we will explain how one multidivision packaged goods company used an audit to identify problems within its product management organization and determine the actions needed to correct them.
Chromatin signatures of cancer

Changes in the pattern of gene expression play an important role in allowing cancer cells to acquire their hallmark characteristics, while genomic instability enables cells to acquire genetic alterations that promote oncogenesis. Chromatin plays central roles in both transcriptional regulation and the maintenance of genomic stability. Studies by cancer genome consortiums have identified frequent mutations in genes encoding chromatin regulatory factors and histone proteins in human cancer, implicating them as major mediators in the pathogenesis of both hematological malignancies and solid tumors. Here, we review recent advances in our understanding of the role of chromatin in cancer, focusing on transcriptional regulatory complexes, enhancer-associated factors, histone point mutations, and alterations in heterochromatin-interacting factors.
Sexual selection for moral virtues.

keywords agreeableness, alternative mating strategies, altruism, assortative mating, behavior genetics, commitment, conscientiousness, costly signaling theory, equilibrium selection, emotion, empathy, ethics, evolutionary psychology, fitness indicators, genetic correlations, good genes, good parents, good partners, human courtship, kin selection, kindness, individual differences, intelligence, mate choice, mental health, moral virtues, mutation load, mutual choice, person perception, personality, reciprocal altruism, sexual fidelity, sexual selection, social cognition, virtue ethics “Human good turns out to be the activity of the soul exhibiting excellence.” Aristotle (350 BC)
Male and female crickets use different decision rules in response to mating signals

Males that produce conspicuous mating signals may attract competitors in addition to sexually receptive females. In manyspecies, for example, females use male calls to locate and choose mates and males respond to competitors’ signals by modulatingsignal production or changing location, thereby escalating or decreasing competition. Do these different receivers make deci-sions using male signals in the same way? We compared how male and female ﬁeld crickets (Gryllus integer) made decisions toapproach male calls differing in calling bout length, a heritable trait known to play an important role in female mate choice.When offered a simultaneous choice between playbacks, both males and females preferred calls with long bouts to those withshort bouts. When presented with calls in isolation, however, only females preferred long-bout calls. Females thus appear to usean internal standard to evaluate calls, whereas males apparently compare the relative attractiveness of alternatives. We also foundthat males assess calls in relation to their own competitive potential by testing 2 hypotheses that make different predictionsregarding variation in male responses to competitor signals. We found no support for the satellite male hypothesis, as unattractivemales did not preferentially approach female-preferred calls; in support of the aggressive displacement hypothesis, males likely towin contests preferentially approached the female-preferred call. Our work demonstrates that even though the sexes process thesame information, different mechanisms of reproductive success (mate location vs. mate attraction) can result in sex differencesin the perception and use of conspeciﬁcs’ signals. Key words: contests, decision rules, Gryllus integer, male phonotaxis, matechoice, satellite males, sexual dimorphism, thresholds. [Behav Ecol]
A COMPARATIVE STUDY OF MICRO-MODELS AND MICRO-MECHANICS BASED BIFURCATION ANALYSIS

Present paper discusses a simplified square cell model (SSCM) derived from elementary mechanics and a finite clement- based 3-phase cylindrical fiber model (FECM) in comparison. The latter is developed with primary object of determining stress variation at the microlevel and follow the evolution of damage. This model is seen to be very effective because of uncoupling of harmonics in the solution process and promises to be an effective tool for nonlinear analysis of composites. It is seen that the determination of the elastic constants depends on the average stresses and strains, and both SSCM and FECM models are satisfactory for this purpose. However, for an accurate determination of initial yielding under combined loading, a micro-model which gives a good description of the variation of stresses across the model is required. Thus square cell models fail to predict accurately the first yield in the context of stress states which are nearly hydrostatic. The nonlinear response of a lamina or a laminate undergoing shear-softening is investigated using the micro-models. The values of the parameters characterizing the nonlinear response of the matrix are determined from the shear response of the lamina with respect to the principal axes. It is found that these values are strongly dependent on the model employed. However, once these parameters are determined, both the models are capable of giving satisfactory predictions, at least in the cases studied here. Accurate correlation between in-situ properties of matrix and its bulk properties is required to get correct nonlinear parameters and to be able to judge correctness of a micro-model.
Complementary observational constraints on climate sensitivity.

[1] A persistent feature of empirical climate sensitivity estimates is their heavy tailed probability distribution indicating a sizeable probability of high sensitivities. Previous studies make general claims that this upper heavy tail is an unavoidable feature of (i) the Earth system, or of (ii) limitations in our observational capabilities. Here we show that reducing the uncertainty about (i) oceanic heat uptake and (ii) aerosol climate forcing can—in principle—cut off this heavy upper tail of climate sensitivity estimates. Observations of oceanic heat uptake result in a negatively correlated joint likelihood function of climate sensitivity and ocean vertical diffusivity. This correlation is opposite to the positive correlation resulting from observations of surface air temperatures. As a result, the two observational constraints can rule out complementary regions in the climate sensitivity-vertical diffusivity space, and cut off the heavy upper tail of the marginal climate sensitivity estimate.
Autoantibodies in cancer: prognostic biomarkers and immune activation

The development of proteomic technologies that display a wide variety of antigenic structures has led to the identification of autoantibodies to cancer-derived tumor antigens. These autoantibodies have been detected in sera from patients with multiple cancer types, and are being evaluated as biomarkers for early cancer detection. It is not known whether these antibodies also contribute to active immune surveillance or even tumorigenicity of developing tumors. Here, we review which tumor antigen-specific antibodies are prognostic biomarkers of cancer outcome, and emerging proteomic methods for the isolation and cloning of these antibodies for potential molecular diagnostics and therapeutics.
4K-5 Shear Wave Velocity Estimation Using Acoustic Radiation Force Impulsive Excitation in Liver In Vivo

Acoustic radiation force can be used to mechanically excite tissue in remote, focused locations, and the tissue response can be monitored using ultrasonic correlation based methods. The speed with which the resulting shear waves propagate away from the focal region can be estimated and used to quantify the material shear modulus, as originally proposed by Sarvazyan et. al. (1998). This imaging approach has been implemented by Bercoff et. al. (2004), using a highly parallel custom ultrasound system, and Helmholtz reconstructions. We have developed a system that is implemented on a commercial scanner using 4:1 parallel processing, and a new algorithm for estimating shear wave speed, which does not require 2nd order temporal and spatial differentiation of displacement data. The method is robust and generates consistent measurements over multiple acquisitions. The goal of our work is to develop this system for the purpose of staging liver fibrosis. The method was used to measure elastic moduli of liver in vivo in healthy human volunteers, and in a rat model, and the moduli obtained with this method are consistent with those reported in the literature
Gender and the stability of consumption: a feminist contribution to post-Keynesian economics

Alan Coddington critiques post-Keynesians for their use of fundamental uncertainty. He argues that fundamental uncertainty should also affect the consumption function, undermining the case for Keynesian macroeconomic policies. This paper shows how contemporary feminist theory provides post-Keynesians with a compelling response to Coddington. It uses the concept of gender as an effect of heteronormativity to integrate ‘the household’, the institution that undertakes consumption spending, into post-Keynesian economics. This gives us a more robust analysis of the sources of consumption stability in a world marked by the fundamental unknowability of the future.
Enhancing precision in time-domain fluorescence lifetime imaging

In biological applications of fluorescence lifetime imaging, low signals from samples can be a challenge, causing poor lifetime precision. We demonstrate how optimal signal gating (a method applied to the temporal dimension of a lifetime image) and novel total variation denoising models (a method applied to the spatial dimension of a lifetime image) can be used in time-domain fluorescence lifetime imaging microscopy (FLIM) to improve lifetime precision. In time-gated FLIM, notable fourfold precision improvements were observed in a low-light example. This approach can be employed to improve FLIM data while minimizing sample light exposure and increasing imaging speed.
Conflict Resolution in an Academic Medical Center: The Ombuds Office

Academic medical centers are complex organizational environments characterized by the independence of faculty and the presence of multiple and overlapping goals. Several factors including competition for resources, financial strains, leadership turnover, and a negative research funding climate, all contribute to an environment with significant potential for conflict by virtue of jealousies, misunderstandings, misinterpretations, dysfunctional relationships, and other com- munication problems. Because conflict can have negative consequences including faculty dissatisfaction, stress, and burnout, it is essential to have strategies for resolving or managing it. In this chapter, we define and discuss conflict and its dynamics, review common formal and informal strategies for managing conflicts in academic medical center settings, and present an approach developed at The University of Texas M. D. Anderson Cancer Center. This alternative approach for conflict management utilizes an organizational ombudsperson, who does not replace existing structures for conflict resolution, but rather supplements them. We review the services that the Ombuds Office provides and describe the characteris- tics of the individuals who came to the M. D. Anderson's Ombuds Office in its first year and the types of issues that were addressed.
The Current Epidemiologic Evidence on Exposures to Poly- and Perfluoroalkyl Substances (PFASs) and Male Reproductive Health

Environmental epidemiologists have given heightened research attention to the class of poly- and perfluoroalkyl substances, or PFASs, in recent years due to their ubiquity, persistence, and evidence of hormonal activity. Whereas prevalence studies have documented changes in serum levels over time among populations in the USA and elsewhere, few human reproductive health studies have been conducted. Given the weight of evidence demonstrating that hormonally active synthetic compounds can impact spermatogenesis, of interest is whether environmental exposures to PFASs are impacting sperm health and male fertility. We review the albeit scant empirical evidence to date to draw attention to this avenue of investigation and to highlight the types of studies that are needed to determine whether and how PFASs impact male reproduction.
Global Access to Maize Germplasm Provided by the US National Plant Germplasm System and by US Plant Breeders

Access to high-yielding germplasm increases agricultural productivity. Plant Variety Protection (PVP) is the most globally used form of Intellectual Property Protection. Commercially available varieties protected solely by PVP can be accessed for further breeding within the country or region of protection. Unlike the practice in most other countries, the USDA has a policy of providing parental inbred lines of hybrids into the public domain following expiration of their protection by PVP. Parental lines and varieties protected by utility patents are also available in the public domain following expiration of protection. These distributions represent fresh opportunities for researchers, hybrid seed producers and plant breeders, nationally and internationally. As a contribution to the continuing debate over ownership and access to plant germplasm we report distributions of maize (Zea mays L.) by the US National Plant Germplasm System (NPGS). During 1988–2015 the NPGS distributed 251,926 packets to 7,582 requestors, fulfilling 10,432 orders. Distributions were primarily to US entities (87%), with 32,520 (13%) to a total of 79 foreign countries. Of the total NPGS maize distributions reported here, 45,968 (18%) were expired or offPVP germplasm. We hope that access provided to this germplasm will act as a reminder that the primary benefit of the Multilateral System under the International Treaty on Plant Genetic Resources for Food and Agriculture (ITPGRFA) is indeed that of having facilitated global access to germplasm and that this concept will remain an important guiding principle during further implementation of the Treaty.
Blackboard and XanEdu: A new model for an old service

Summary This paper will discuss a limited partnership between the University of Kansas and XanEdu to evaluate their production of course packs and the acceptance of this product by faculty and students. This analysis will include project design and management information, identification of issues needing to be addressed, and an assessment of the project at its conclusion. The paper concludes with a model for providing broad access to Blackboard-based electronic reserve readings that is based on an evaluation of the pilot project.
Reagan's radical challenge

The tough talk coming from Washington made Mikhail Gorbachev look good to Europeans—and Europeans began looking better to each other, too. Reagan backed down but left the Atlantic ties weakened.
Reef Biology and Geology – Not Just a Matter of Scale

The geological distribution and developmental history of coral reefs have been largely controlled by physical factors such as plate tectonics, sea-level changes, wave energy, salinity, light, temperature, nutrients, sediment, and antecedent topography. Although the geological and biological patterns have generally been consistent over the past 12,000 years, sub-millennial intervals of variation remind us that long-term patterns provide only part of the picture. Looking forward, changes in seawater temperature, storm intensity, aragonite saturation state and pH may bring a major shift in the balance between carbonate production, destruction and export. While rising sea level alone will probably not significantly change reef communities or over-top low reef islands, even small increases of water depth will have disproportionate effects on the wave energy passing over the reef crest. Moreover, the impacts of increasing storminess will rival declining coral cover as a major control over the carbonate budget of coral reefs in the coming century. Understanding what is to come will require a perspective that is impossible from any single discipline.
504 ANALYSIS OF NUCLEOCYTOPLASMIC DISTRIBUTION OF THE ONCOPROTEIN SKIN IN HUMAN ALVEOLAR RHABDOMYOSARCOMA CELLS BY IMMUNOELECTRON MICROSCOPY.

The Ski oncoprotein functions as a transcriptional corepressor in transforming growth factor β signaling, regulating cellular proliferation, differentiation, and development for several tissues, including skeletal muscle. Multiple human cancers overexpress Ski, which may play a part in malignant cellular transformation. This research focuses on Ski subcellular localization in rhabdomyosarcoma, a pediatric muscle cell cancer. Quantitative analysis of the cellular distribution of the oncoprotein Ski in a rhabodomyosarcoma cell line and a normal human skeletal muscle cell line shows a denser nuclear than cytoplasmic distribution in both cell lines. This analysis shows a significant difference (p = .013) in the nuclear to cytoplasmic ratio of Ski between skeletal muscle cells (mean = 1.38) and rhabodomyosarcoma cells (mean = 2.06). Likewise, there is a significant difference in the fractional distribution to nuclear and cytoplasmic Ski (p = .017), with a skeletal muscle cell line mean of 0.56 and a mean distribution in the rhabdomyosarcoma cell line of 0.65. This indicates that there is a significant quantitative difference between normal skeletal muscle cells and rhabodomyosarcoma cells in the intracellular distribution of the oncoprotein Ski that trends toward nuclear staining.
Current Situation of the Construction of Agricultural Information Resource in Hebei Province and Its Developmental Countermeasures

This paper has reviewed the current situation of the construction of agricultural information resource construction in Hebei province and its major problems,and put forward corresponding countermeasures.
COMMUNITY & COLLABORATION: The Community Partnerships Toolkit

Le Community Partnership Toolkit est un site web regroupant des informations sur le partenariat au sein de l'enseignement superieur en general, et en particulier sur le partenariat en culture de l'information. Son but est de repondre aux questions les plus frequemment posees sur ces themes, en fournissant a la fois le contenu et la procedure.
Case Analysis III: Davidson’s Approach in the Explanatory-Role Project

In this chapter, for the sake of understanding the explanatory-role dimension of the philosophical concern with truth and of making the case for the account of the explanatory role of the concept of truth in SPT, I carry out a case analysis of Donald Davidson’s approach in regard to the explanatory-role project of the philosophical concern with truth. For this purpose, the goal of this chapter is limited to the explanatory role played by the concept of truth in philosophical inquiries, instead of a comprehensive examination of the more general topic on the role of the truth norm in general knowledge pursuit and in our folk life.
The Study of Developmental Stages

…discreteness of levels of thinking age by age was emphatically not found. Each type of thinking was found to extend over the entire age range studied, suggesting that causality does not develop in saltatory stages.
Machine Intelligence and the Ethical Grammar of Computability

Since the publication of Alan Turing’s famous papers on “machine intelligence” over six decades ago, questions about whether complex mechanical systems can partake in intelligent cognitive processes have largely been answered under the analytical rubric of their capacity successfully to simulate symbol-mongering human behavior. While this focus on the mimetic potential of computers in response to the question “Can machines think?” has come to be accepted as one of the great bequests of Turing’s reflections on the nature of artificial intelligence, I argue in this paper that a closer look at Turing’s oeuvre reveals an especially informative tension between the pragmatic and normative insights, which enabled him in 1936 to formulate his pioneering version of the theory of mechanical computability, and his later attempt to argue for a simplistic notion of “machine intelligence” as an effectual imitation of the human mind. In fleshing out the source of this tension, I endeavor to show how the mimetic model of “thinking machines” that Turing eventually embraces is ultimately at cross-purposes with the normative-pragmatic insights by which he reached his original innovations in computability theory and combinatorial logic.
Historical Legacies of Communism in Russia and Eastern Europe: Communist Development and the Postcommunist Democratic Deficit

This article analyzes the post-communist regime track record in comparative perspective and reevaluates the impact of modernization on the democratic prospects in developing countries. The analysis shows that ex-communist countries were less democratic than their socioeconomic development levels would have predicted, and that the development-democracy link was different than elsewhere, due to the distorted nature of communist development. The article then traces this democratic deficit to individual-level deficits in democratic attitudes and civic and political participation. Post-communist democratic prospects are further undermined by the fact that the participatory deficit is greater among the relatively prodemocratic middle class, than among the lower class, which had experienced mobilization from above under communism, but was less likely to subscribe to democratic values than lower classes in non-communist countries.
Postoperative sepsis prediction in patients undergoing major cancer surgery

Abstract Background Cancer patients are at increased risk for postoperative sepsis. However, studies addressing the issue are lacking. We sought to identify preoperative and intraoperative predictors of 30-d sepsis after major cancer surgery (MCS) and derive a postoperative sepsis risk stratification tool. Methods Patients undergoing one of nine MCSs (gastrointestinal, urological, gynecologic, or pulmonary) were identified within the American College of Surgeons National Surgical Quality Improvement Program (2005-2011, n = 69,169). Multivariable adjusted analyses (MVA) were performed to identify the predictors of postoperative sepsis. A composite sepsis risk score (CSRS) was constructed using the regression coefficients of predictors significant on MVA. The score was stratified into low, intermediate, and high risk, and its predictive accuracy for sepsis, septic shock, and mortality was assessed using the area under the curve analysis. Results Overall, 4.3% ( n = 2954) of patients developed postoperative sepsis. In MVA, Black race (odds ratio [OR] = 1.30, P = 0.002), preoperative hematocrit P = 0.022), cardiopulmonary and cerebrovascular comorbidities ( P 3 ( P P P P versus 9.7% in high-risk patients. Similarly, 30-d mortality rate varied from 0.5% to 5.5% (10-fold difference) in low-risk patients versus high-risk patients. Conclusions Our study identifies the major risk factors for 30-d sepsis after MCS. These risk factors have been converted into a simple, accurate bedside sepsis risk score. This tool might facilitate improved patient–physician interaction regarding the risk of postoperative sepsis and septic shock.
Sofosbuvir: an antiviral drug with potential efficacy against Zika infection

• There is an 80% overlap in the amino acids of Zika virus (ZIKV) and hepatitis C virus (HCV) RNA polymerase, which binds sofosbuvir.
Asymptotic estimate of variance with applications to stochastic differential equations arises in mathematical neuroscience

ABSTRACTMatrix representation of a limit of variance for circular process is given. It is shown that the variance is asymptotically measured by the decrease in spectral energy in one step of a Markov chain. Then we apply this result to a stochastic differential equation with parametric noise (which arises in mathematical neuroscience) and demonstrate how the results can be used to analyze propagation of a signal in sound mechanism.
Heat capacity, resistivity, and angular dependent magnetization studies of single crystal Nd1+∊Fe4B4 for ∊≈17

Abstract Advances in crystal growth have allowed for synthesis of large single crystals of Nd 1 + ∊ Fe 4 B 4 , a well-known phase with a modulated structure. As a result we are able to report heat capacity and resistivity measurements on a single crystal Nd 1 + ∊ Fe 4 B 4 sample with a distribution of ∊ that skews towards the solubility limit of Nd near ∊ ≈ 1 7 . Heat capacity measurements show evidence of crystal field splitting at temperatures higher than the long-range ferromagnetic Curie temperature. Heat capacity, resistivity, and magnetization measurements all confirm a Curie temperature of 7 K which is lower than previously reported values in the Nd 1 + ∊ Fe 4 B 4 system. We also perform measurements of the angular dependence of the magnetization and discover behavior associated with the magnetic anisotropy that is inconsistent with the simple description previously proposed.
Experimental comparisons of P-T symmetric magneto-electric interactions in molecular liquids

Experimental comparisons of optically-induced magnetic scattering in four liquids agree with recent quantum theoretical predictions of magneto-electric interactions obeying P-T symmetry.
Jung and Complex Psychology

Jung’s early interest in a dynamic psychology of the subconscious is evident in Aniela Jaffe’s biography, Memories, Dreams, Reflections (1963a), historically put forward as a book by Jung himself.1 There, Jaffe has Jung recounting from a young age his preoccupation with dreams, visions, and inner psychic events related to an understanding of his own personality.2 We see this interest again in 1898 when Jung read DuPrel, Swedenborg, Passavant and others, and decided, because of the absence of any such dynamic language in the prevailing mental science of the times, to go into psychiatry as a specialty. His dissertation on Helene Preiswerk, his studies of the Word Association Test, and his psychotherapeutic work with hospitalized schizophrenics under Bleuler transformed a youthful interest into a full-fledged and life-long quest for a dynamic psychology of the interior life.
Eating habits of adolescents and education by nurses on primary prevention

Abstract The goal of the article is to present the results of the research which is focused on the eating habits of adolescents. These habits are the basis for education in the field of nursing and healthy lifestyle. The data collection was carried out using a non-standardized questionnaire. The sample group of respondents consisted of 1130 people living in South Bohemia, who were 15–18-years-old (the average age was 16.8 years), of which 732 (64.8%) were girls and 398 (35.2%) were boys. The research was carried out among pupils of four-year high schools, middle schools of health (MSH), middle vocational schools and vocational school institutions in the study field cook/waiter (VSI). The dependence of the monitored variables on the type of the monitored school was assessed using the chi-squared test (possibly Fisher's exact test). The results showed that high school pupils ate regularly 5 or 6 times a day, in contrast to other types of schools. High school pupils had a higher frequency of consuming daily meals during the week. Pupils from middle vocational schools had the worst results (their daily consumption of sweetened beverages was more than pupils from other schools). Pupils from middle vocational schools were more influenced by TV commercials in the selection of food. The results of our research point out various flaws in the daily and weekly frequency of food consumption in pupils from selected types of schools, while pupils from vocational schools were disadvantaged. For this reason, education in nutrition and lifestyle should be focused on the prevention of becoming overweight and obese and should be included in the routine care of children and adolescents.
Protective and Risky Social Network Factors for Drinking During the Transition From High School to College.

Objective:The transition from high school to college is a unique developmental period to examine the relationship between social networks and alcohol use, because during this transition, students enter new environments and alcohol use becomes more pervasive. The aim of this study was to examine the extent to which personal social networks change during this transition and to examine how changes in the composition of networks are related to alcohol use.Method:Participants (N = 374, 57.8% female) reported on their alcohol use and provided information about individuals in their social network before and immediately after their first year of college. These network members were matched across the two observations and were classified as either carryover (i.e., named at both assessments), dropped (i.e., named at only the first assessment), or added (i.e., named at only the second assessment).Results:We found robust turnover, such that only 22% of network members were retained from the first observation to the se...
Prospective Outcome Analysis of the Safety and Efficacy of Partial and Complete Cryoablation in Organ-confined Prostate Cancer.

Objective To determine the rate of complications and change in International Prostate Symptom Score and Sexual Health Inventory for Men scores following cryotherapy treatment of low- and intermediate-risk prostate cancer. The secondary end points were the change in prostate-specific antigen post cryotherapy and biopsy-proven recurrence. Materials and Methods Enrollment occurred from 2007 to 2015 to assess long-term complications of cryotherapy. A prostate biopsy was performed at 1 year or in the event of biochemical failure. Subjects were staged and graded by standard 12- to 14-core transrectal ultrasound (TRUS) biopsy. A subset of subjects underwent additional 3-dimensional mapping biopsy if the cancer was suspected to be downgraded. Analyses of functional outcomes were stratified into focal and nonfocal treatments. Results The study consisted of 393 men with low- and intermediate-risk prostate cancer, aged 44-89 years. Patient IPSS scores improved significantly in the nonfocal treatment strata at all time points and after 1 year in the focal strata with a median drop at 1 year of 4 points (P .7). Eighty-two patients (20.9%) had a rise in prostate-specific antigen resulting in biochemical failure. Seventy patients had detected recurrence for an overall recurrence rate of 20.4% in 343 patients. A total of 109 patients (27.7%) reported urinary retention and urgency post cryotherapy, with 15.3% requiring catheterization for up to 3 weeks. Thirty-seven patients (9.4%) experienced urethral meatal stricture, and 36 patients (9.2%) reported unresolved new-onset erectile dysfunction. Conclusion Complication rates, most significantly erectile dysfunction, are decreased in this study compared with those previously reported in the literature for cryotherapy for prostate cancer.
Nadir of Public Morality: The Age of the Drone

This chapter develops President Obama’s use of drone warfare, at the center of his policy framework, in greater detail, to bring out its wider historical-philosophical context. Beyond tactics, strategy, personality, and leadership, this is both a moral question and, by implication, a psychoanalytic snapshot of the society that approves, or is indifferent to, this course.
Introduction to a Battle Plan for Supporting Military Families

Since September 11, 2001, all branches of our federal government, as well as state and local governments, corporations, advocacy groups, philanthropies, researchers, and many others have taken action to support military families during and following their service. Often, these efforts were mutually supportive, but sometimes they competed or conflicted with each other. While many efforts were successful, others failed to achieve their potential or were misdirected. To better understand these dynamics, the Military Family Research Institute at Purdue University called together experts representing many sectors to present, discuss, and reflect with one another with the goal of building a contingency plan for supporting families for the next major conflict. Participants were given the mission of distilling messages and action items for future leaders about the action items they should immediately implement when they realize that transformational change in family support will be required. Rather than attempting to identify specific programs or policies that should be created, the focus was on processes that should be put in place, questions that should be asked, and experts who should be consulted when trying to make good choices. The event was called the “Battle Plan for Supporting Families Symposium,” and this book is the result.
The Queer of Color's Mother: Ryan Rivera, Audre Lorde, Martin Wong, Danh Vō

A turn to the work of four artists: Danh Vō, Ryan Rivera, Martin Wong, and Audre Lorde, this meditation on the relationship between reproductive labor and performance’s mode of reproduction attempt...
Electronic Health Record Usability Issues and Potential Contribution to Patient Harm

This study analyzed patient safety reports in and near Pennsylvania from 2013 through 2016 to identify those that contained explicit language associating possible patient harm with an electronic health record usability issue.
Tumorigenesis and the angiogenic switch

It has become evident that we cannot understand tumour growth without considering components of the stromal microenvironment, such as the vasculature. At the same time, the tumour phenotype determines the nature of the tumour vasculature. Much research is now devoted to determining the impact of angiogenesis on tumour development and progression, and the reciprocal influences of tumour products on the microvasculature. A more detailed understanding of the complex parameters that govern the interactions between the tumour and vascular compartments will help to improve anti-angiogenic strategies-- not only for cancer treatment, but also for preventing recurrence.
Recent Developments in the Uneasy Tension Between Family and Career: Competency-Related Perceptions of Women and Mothers

In this chapter I summarize my own research, other current research, and theory, as well as provide anecdotal evidence from the popular press regarding career-related perceptions of women and mothers at work. Women are often categorized as less career-dedicated and career-competent because of real or perceived caregiving roles, which tend to be devalued even in contemporary work environments. I conclude with the significance of this phenomenon for career-active female spouses of military personnel and women seeking leadership positions in the military, as well as ideas for future research and implications for practitioners.
Chronic Models of Endotoxemia and Sepsis: Lessons from Both a Canine Peritonitis and a Human Endotoxemia Model

Sepsis is a complex disorder that is comprised of a series of host responses to both exogenous (microorganism-derived) and endogenous (produced by the host) toxins and mediators. It is a disease of rapid onset, with often subtle and nonspecific presenting signs and symptoms, associated with a high mortality rate despite the rapid institution of aggressive treatment.
Genetic Counselors: Bridging the Oncofertility Information Gap

The oncofertility information gap is caused by insufficient patient education on the effects of cancer treatment on fertility and the option of fertility preservation. Many cancer patients do not recall ever discussing the impact of cancer treatment on fertility with their oncologist; because of this, multidisciplinary care that includes fertility treatment is especially valuable for bridging the information gap. Genetic counselors—who are specifically trained to deliver options and facilitate decision making while also focusing on psychosocial issues—are an untapped resource for educating cancer patients about fertility impairment and fertility preservation options. Genetic counselors use a nondirective counseling approach to facilitate a shared decision-making process with patients. Additionally, genetic counselors provide emotional support and can assess when to make a mental health referral. Genetic counselors believe that fertility preservation discussions are important and a part of the genetic counselor role, yet the majority of cancer genetic counselors are not discussing fertility preservation or referring patients, often because of the timing of cancer treatment. A majority (79.7 %) of genetic counselors have reported that the number one barrier to discussing fertility preservation is seeing a patient after they have already undergone cancer treatment. If healthcare providers refer individuals who have a personal or family history suggestive of a hereditary or familial cancer prior to cancer treatment or prophylactic surgery, genetic counselors would have an opportunity to discuss fertility preservation with patients, thereby effectively bridging the oncofertility information gap.
Abstract 4334: Linked read whole genome sequencing reveals pervasive chromosomal level instability and novel rearrangements in brain metastases from colorectal cancer

Little is known about the genomic features of brain metastases from colorectal cancer (CRC) and the contributing genetic factors. We conducted an analysis of large-scale structural aberrations, including chromosome aneuploidies, with a method called linked-read whole genome sequencing and a new somatic rearrangement detection software tool (ZoomX) to better understand the genomic architecture of brain metastases from CRC. We resolved on average 145 distal inter- and intra-chromosomal somatic junctions per sample with their exact haplotype information and basepair level breakpoints. In addition, we used a new haplotyping method based on these imbalances to generate cancer chromosome haplotypes of up to 146 Mbp long. We identified extensive chromosomal-level instability (CIN) in these cancer genomes, with an average of 90 large-scale copy number aberrations per sample in sizes ranging from hundreds of Kbp to hundreds of Mbp. A substantial fraction of CIN is likely attributable to earlier chromothripsis events. For example, we identified multiple chromothripsis events disrupting the loci of known cancer genes such as TP53, an essential colon cancer driver. We identified novel rearrangements including an oncogenic gene fusion; e.g. SET/DPP10 among these metastatic samples. A majority of chromosome arms demonstrated an allelic imbalance across all of the samples. In summary, the analysis revealed pervasive chromosome-level genome instability as a potential contributor to devastating brain invasion by CRC. It also demonstrated the advantages of linked-read whole genome sequencing. This approach is cost-effective and represents a high-resolution tool to assess genome-wide rearrangements and to generate megabase-scale haplotypes. Citation Format: Li C. Xia, John M. Bell, Christina Wood-Bouwens, Daniel A. King, GiWon Shin, Stephanie Greer, Ian D. Connolly, Melanie H. Gephart, Hanlee P. Ji. Linked read whole genome sequencing reveals pervasive chromosomal level instability and novel rearrangements in brain metastases from colorectal cancer [abstract]. In: Proceedings of the American Association for Cancer Research Annual Meeting 2018; 2018 Apr 14-18; Chicago, IL. Philadelphia (PA): AACR; Cancer Res 2018;78(13 Suppl):Abstract nr 4334.
Can the Laparoscopic Approach for Adhesive Small Bowel Obstruction be Used in Octogenarians? An Observational Study Using ACS NSQIP.

Abstract Background With the population of octogenarians projected to increase fourfold by 2050, we sought to compare outcomes of laparoscopic versus open approach in octogenarians requiring surgery for adhesive small bowel obstruction (SBO). Methods/Materials and methods Using 2006-2015 American College of Surgeons National Surgical Quality Improvement Project, we identified patients aged ≥80 y who underwent emergency surgery within 1 d of admission for SBO. Risk variables of interest included age, sex, race, body mass index, preoperative sepsis, and American Society of Anesthesiologists (ASA) classification. Outcomes included length of stay, mortality, and pneumonia. Univariable and multivariable analyses were performed. Results Eight hundred fifty-six patients were identified. Six hundred ninety-nine (81.7%) underwent laparotomy; 157 (18.3%) underwent laparoscopy. Twenty-four (15.3%) of laparoscopic cases were converted. There was no difference between the open and laparoscopic groups in age, and race, preoperative albumin, or preoperative sepsis. The open group had higher rates of totally dependent functional status, congestive heart failure, chronic obstructive pulmonary disease, and higher ASA class. There was no difference in operative time. Laparoscopy was associated with shorter length of stay. The open approach showed higher rates of postoperative pneumonia, myocardial infarct, and mortality. Multivariable analysis showed increased age, functional status, preoperative albumin, and ASA class associated with mortality. The operative approach was not associated with mortality. Postoperative pneumonia was associated with male sex and open approach. Conclusions Age, preoperative functional status, low preoperative albumin, and ASA classes IV and V were associated with mortality, while the open approach and male sex were associated with postoperative pneumonia. Octogenarians who present with SBO due to adhesive disease may benefit from an initial laparoscopic exploration. Further prospective studies are warranted.
CURT: A Real-Time Scheduling Algorithm for Coexistence of LTE and Wi-Fi in Unlicensed Spectrum

Carrier-Sensing Adaptive Transmission (CSAT) is a major approach from industry to address coexistence between LTE and Wi-Fi in unlicensed bands. Under CSAT, a key problem is the design of a scheduling algorithm to allocate radio resources across multiple channels and a large number of sub-channels. This paper investigates this scheduling problem through an optimization formulation with the objective of minimizing LTE’s adverse impact on Wi-Fi users. This is achieved by optimal allocation of radio resources at channel and sub-channel levels to meet each LTE user’s uplink and downlink rate requirements. Special considerations of channel conditions are given during LTE scheduling. A major challenge here is to obtain an optimal (or near-optimal) scheduling solution on ~1 ms time scale — a stringent timing requirement for the algorithm to be useful in the field. Our main contribution is the development of CURT, a scheduling algorithm that can obtain near-optimal solution in ~1 ms. CURT exploits the unique structure of the underlying optimization problem and decomposes it into a large number of independent sub-problems. These sub-problems can be solved efficiently and in parallel by GPU multi-processors. By implementing CURT on Nvidia GPU/CUDA platform, we demonstrate that CURT can indeed deliver near-optimal scheduling solution in ~1 ms and meet all our design objectives.
On-chip highly sensitive saliva glucose sensing using multilayer films composed of single-walled carbon nanotubes, gold nanoparticles, and glucose oxidase

Abstract It is very important for human health to rapidly and accurately detect glucose levels in biological environments, especially for diabetes mellitus. We proposed a simple, highly sensitive, accurate, convenient, low-cost, and disposable glucose biosensor on a single chip. A working (sensor) electrode, a counter electrode, and a reference electrode are integrated on a single chip through micro-fabrication. The working electrode is functionalized through a layer-by-layer (LBL) assembly of single-walled carbon nanotubes (SWNTs) and multilayer films composed of chitosan (CS), gold nanoparticles (GNp), and glucose oxidase (GOx) to obtain high sensitivity and accuracy. The glucose sensor has following features: (1) direct electron transfer between GOx and the electrode surface; (2) on-a-chip; (3) glucose detection down to 0.1 mg/dL (5.6 μM); (4) good sensing linearity over 0.017–0.81 mM; (5) high sensitivity (61.4 μA/mM-cm2) with a small reactive area (8 mm2); (6) fast response; (7) high reproducibility and repeatability; (8) reliable and accurate saliva glucose detection. Thus, this disposable biosensor will be an alternative for real time tracking of glucose levels from body fluids, e.g. saliva, in a noninvasive, pain-free, accurate, and continuous way. In addition to being used as a disposable glucose biosensor, it also provides a suitable platform for on-chip electrochemical sensing for other chemical agents and biomolecules.
(73) Examining the incidence of critical findings in intubated patients receiving routine daily chest x-rays in a pediatric intensive care unit

Purpose: The clinical utility of performing daily routine chest radiographs on intubated patients is an area of controversy. Furthermore, there is a potential role for serial examination using bedside lung ultrasonography to replace the daily chest x-ray for assessment of lung pathology with the benefit of minimizing radiation exposure and mitigating cost. This study represents preliminary data regarding chest x-ray utilization, which is part of a broader study examining the use of serial lung ultrasound in intubated patients in a pediatric ICU. The purpose of the present study is to examine how often chest x-rays …