cssi/SciSciGPT-SciSciNet huggingface dataset:
Pilot Study of Oral Valganciclovir Therapy in Patients With Classic Kaposi Sarcoma

We conducted a clinical trial of oral valganciclovir, a drug with in vitro activity against Kaposi sarcoma (KS)―associated herpesvirus (KSHV), in classic KS. Five human immunodefi- ciency virus―seronegative participants received valganciclovir for up to six 4-week cycles at doses used for cytomegalovirus infection. None of the study subjects showed an objective response; KS progressed in 4 subjects after 1―4 cycles and remained stable in 1 subject after 6 cycles. KS biopsies showed minimal lytic KSHV antigen and gene expression at baseline and no treatment-associated changes. Although valganciclovir was not active against KS in this setting, other appropriately targeted anti-herpesviral strategies may prove to be more effective.
A spatial cost of living index for Colombia using a microeconomic approach and censored data

This article describes a methodology to calculate a Spatial Cost of Living (SCOL) index using the Colombian data for 2006 that considers the microeconomic behaviour of households. Estimating an Almost Ideal Demand System (AIDS) to recover the expenditure function of the 23 main Colombian cities, the index is compared to the fixed basket approach and to an alternative methodology proposed by Romero (2005). This comparison suggests that the index is biased when the substitution effects are not considered, and this bias increases when the difference in expenditure levels between cities increases. According to our calculations, Bogota is still the most expensive city in the country.
23.2: A High Resolution Stereoscopic Computer Projection Display For Surgical Planning

This paper details the construction of a high resolution, stereoscopic rear-projection display specially optimized for collaborative, computer-based surgical planning. The projection display was designed to address a number of drawbacks that exist in the use of other, more general-purpose projection displays for this task
Synthesis and Physical Properties of Symmetrical and Non-symmetrical Triacylglycerols Containing Two Palmitic Fatty Acids

A series of symmetrical (ABA) and non-symmetrical (AAB) triacylglycerol (TAG) isomers containing “A,” palmitic (P; 16:0) acid, and “B,” either oleic (O; 9c-18:1), elaidic (E; 9t-18:1), linoleic (L; 9c,12c-18:2) or linolenic (Ln; 9c,12c,15c-18:3) fatty acids were synthesized by esterification of the thermodynamically more-stable 1,3-di- or 1(3)-monoacylglycerols [1,3-DAG or 1(3)-MAG], respectively. 1,3-dipalmitoylglycerol (1,3P-DAG) was esterified with O, L or Ln acid to prepare the symmetrical TAG isomers POP, PLP and PLnP, while the O- E-, L- and Ln-1(3)MAG precursors, synthesized or obtained commercially, were esterified with P acid to prepare the non-symmetrical TAG isomers OPP, EPP, LPP and LnPP, respectively. The drop point(s), solid fat content and melting point values of the synthesized TAG were determined. The 1,3-dipalmitoylglycerol (1,3P-DAG) and 1(3)P-MAG precursors were prepared, in multi-gram quantities, by partial glycerolysis (glycerol/p-toluenesulfonic acid) of tripalmitin. After fractionation by silica gel chromatography, the 1(3)P-MAG and 1,3P-DAG isomers (ca. 80% of total MAG or DAG) were purified (>98%) by crystallization from acetone [silver ion-HPLC was utilized to determine the structural purities of the DAG (or MAG) precursors, and the synthesized TAG]. Esterification of the appropriate, thermodynamically more-stable MAG or DAG precursors was found to be a very versatile method for synthesis (in 80–90% yields) of multi-gram (3–5 g) quantities of symmetrical and non-symmetrical TAG isomers, in chemical and structural purities of >96 and 97–99%, respectively.
Research Related to Roads in USDA Experimental Forests

Forest roads are essential in experimental forests and rangelands (EFRs) to allow researchers and the public access to research sites and for fire suppression, timber extraction, and fuel management. Sediment from roads can adversely impact watershed health. Since the 1930s, the design and management of forest roads has addressed both access issues and watershed health. Road design and management practices developed from research on roads in EFRs in the 1950s are applied throughout the USA and the world. Long-term data sets on watersheds with and without roads have helped us better understand the role of roads in runoff processes. Data collected from roads in EFRs have contributed to the development of hydrology and erosion models used throughout the world. As forest management and utilization practices change, such as gas abstraction, wind energy generation, and off-road vehicle recreation, research will be necessary to address the watershed impacts of roads and other access networks to support those new uses.
Women’s Breast Cancer: Effects of Physicians Service Management on the Level of Awareness

This study is a descriptive study aiming to evaluate awareness about breast cancer of female family physicians. In this project: the aim of family physicians investigation is to analyse awareness of breast cancer and socio-demographic characteristics. In May 2015 the survey, consisting of 38 questions, in participated 100 family physicians was conducted. The female family physicians surveyed: age - 45 years and older (39%); married (80%); family types - nuclear family (76%); the fist pieces - at the age between 13-15 years (59%); age of fist pregnancy - 25-29 years (52%); parity - 2 (36%), lower (68%), non-abortion (73%); recent child birth form caesarean section (75%); number of living children - 2 (58%); lactation period - 1 year (47%). As has been found age, marital status, family types, age of fist menstruation, fist pregnancy, family type, before family planning methods are not used; they entered menopause and no smear (vaginal discharge swab) aldirip ignore them; the absence of risk factors for developing breast cancer is the personal history of breast cancer; taking estrogen; the risk factors of developing breast cancer; no birth control pills taken; the breast cancer caught in that the risk factor is not the baby breastfed; the palpable mass in the breast or underarm (stiffness, swelling); whether signs of breast cancer, nipple inward withdrawal, collapse, or whether it is a symptom of breast cancer deformities; whether edema in breast skin, swelling and being inward shrinkage (orange peel) are signs of breast cancer; breast is not growth or signs of breast cancer asymmetry, self breast examination (SBE) - when it is to be done; breast self-examination (BSE) - how it is tp be done; tightening the availability of nipples; hands the hands of the examination which used their figers;, they have not taken any mammogram; it was found that the impact on mammography issues they posed for the fist time in many years.
Inactivation of the lateral orbitofrontal cortex increases drinking in ethanol-dependent but not non-dependent mice.

Long-term consumption of ethanol affects cortical areas that are important for learning and memory, cognition, and decision-making. Deficits in cortical function may contribute to alcohol-abuse disorders by impeding an individual's ability to control drinking. Previous studies from this laboratory show that acute ethanol reduces activity of lateral orbitofrontal cortex (LOFC) neurons while chronic exposure impairs LOFC-dependent reversal learning and induces changes in LOFC excitability. Despite these findings, the role of LOFC neurons in ethanol consumption is unknown. To address this issue, we examined ethanol drinking in adult C57Bl/6J mice that received an excitotoxic lesion or viral injection of the inhibitory DREADD (designer receptor exclusively activated by designer drug) into the LOFC. No differences in ethanol consumption were observed between sham and lesioned mice during access to increasing concentrations of ethanol (3-40%) every other day for 7 weeks. Adulterating the ethanol solution with saccharin (0.2%) or quinine (0.06 mM) enhanced or inhibited, respectively, consumption of the 40% ethanol solution similarly in both groups. Using a chronic intermittent ethanol (CIE) vapor exposure model that produces dependence, we found no difference in baseline drinking between sham and lesioned mice prior to vapor treatments. CIE enhanced drinking in both groups as compared to air-treated animals and CIE treated lesioned mice showed an additional increase in ethanol drinking as compared to CIE sham controls. This effect persisted during the first week when quinine was added to the ethanol solution but consumption decreased to control levels in CIE lesioned mice in the following 2 weeks. In viral injected mice, baseline drinking was not altered by expression of the inhibitory DREADD receptor and repeated cycles of CIE exposure enhanced drinking in DREADD and virus control groups. Consistent with the lesion study, treatment with clozapine-N-oxide (CNO) further enhanced consumption only in CIE exposed DREADD mice with no change in air-treated mice. These results suggest that the LOFC is not critical for the initiation and maintenance of ethanol drinking in non-dependent mice, but may regulate the escalated drinking observed during dependence.
Stress and Vibration Analysis for Woven Composite Axial Impeller

A stress and vibration analysis procedure is developed to assess the static and dynamic characteristics of the Woven Composite Axial-Impeller under loading conditions particular to centrifugal force. This procedure is based on Finite Element Analysis (FEA, commercial software ABAQUS) results. A low-cost, light-weight, high-performance, composite turbomachinery impeller with uniquely designed blade patterns are evaluated. Understanding the stress-strain behavior of fiber composite laminates to ultimate failure and the ability to predict ultimate strength is critical in the design of safe and lightweight impellers. To determine failures, the maximum stress failure criterion is used. In order to avoid resonance which can make impellers suffer a significant reduction in the design life, the designer must calculate the natural frequency and modal shape of impeller to analyze the dynamic characteristics. The results show that composite material Kevlar fiber/epoxy matrix enables the impeller to run at high tip speed of 450m/s and withstand the stresses; no critical speed will be matched during start-up and shut-down and that mass imbalances of the impeller shall not pose a critical problem.Copyright © 2010 by ASME
Inactivation of p53 results in high rates of homologous recombination

Using a plasmid substrate which integrates into the genome, we determined that the rate of homologous recombination was suppressed by p53. Human tumor cell lines, mutant or null for p53 had recombination rates 10 000-times greater than primary fibroblasts. When isogenic cell pairs from tumor cells or primary fibroblasts were compared, differing only in one genetic change which inactivated p53, the recombination rate increased >100-fold. Functional inactivation of p53 by dominant mutant p53, by large T antigen of SV40 virus, by E6 protein of human papilloma virus, or by genetic deletion led to the same result. Our results suggest that p53 suppresses spontaneous homologous recombination, and that p53 is not required for recombination to proceed. The mechanism of recombination suppression may be related to the reported association of p53 with Rad 51, but the functional consequences of this association are not yet established. It is suggested that suppression of homologous recombination is the means by which p53 maintains genetic stability.
Periodic Motions in the Periodically Forced Oscillator With Multiple Discontinuities

In this paper, the stability and bifurcation of periodic motions in periodically forced oscillator with multiple discontinuities is investigated. The generic mappings are introduced for the analytical prediction of periodic motions. Owing to the multiple discontinuous boundaries, the mapping structures for periodic motions are very complicated, which causes more difficulty to obtain periodic motions in such a dynamical system. The analytical prediction of complex periodic motions is carried out and verified numerically, and the corresponding stability and bifurcation analysis are performed. Due to page limitation, grazing and stick motions and chaos in this system will be investigated further.Copyright © 2006 by ASME
A Preterm Female Who Has a Distended Abdomen and Absent Bowel Sounds

### Prenatal History: ### Birth History and Presentation: The infant was delivered by repeat cesarean section. Amniotic fluid was meconium-stained. After delivery, the infant was intubated, and meconium was suctioned from the trachea. Apgar scores were 5 and 8 at 1 and 5 minutes respectively. She was transported to the neonatal intensive care unit while intubated. The patient edematous at birth. Surfactant was administered through the endotracheal tube. The patient’s abdomen was distended, and an abdominal radiograph was obtained, with findings similar to the abdominal radiographs shown on the previous page and below. An orogastric tube was placed for suctioning. Paracentesis was performed, with drainage of brown fluid. A surgical drain …
Viable term pregnancy despite “subluteal” serum progesterone levels in the first trimester

This is a report of a 34-year-old patient with a 3-year history of unexplained infertility, who conceived after IVF-ET. Her serum P levels were < 2.0 ng/mL (conversion factor to SI unit, 3.180) between 5 and 6 weeks of gestation. She subsequently delivered a viable infant at term.
C.G.J. Jacobi: Algorist par-excellence

The remarkable powers of C.G.J. Jacobi can be best seen in the theory of theta functions of which he was the founder. Ramanujan has been compared to Jacobi and Euler for sheer manipulative ability. This article describes the life of Jacobi and the monumental contributions he made even though he was plagued with health problems. A discussion of Jacobi’s seminal work on theta functions is included, and a comparison is drawn with Ramanujan’s own theory of theta functions.
Women in Europe — The Situation

Sexual equality is a basic principle of community law. Guaranteeing equality of opportunity between both sexes and combating any kind of gender discrimination is one of the established objectives of the EU. This is why the Commission is also involved in other arenas, as evidenced in the support for the outcomes of the international principles arising from the Beijing Platform for Action and Millennium Development Goals.
Robust bidirectional continuous electrowetting based on metal–semiconductor (M–S) diodes

We demonstrate bidirectional continuous electrowetting by embedding metal–semiconductor diodes in the electrowetting substrate. Unlike conventional electrowetting on dielectric, bidirectional continuous electrowetting uses a single electrode pair to actuate a droplet through long distances. As long as the voltage potential is maintained between two end electrodes, the droplet moves toward the electrode with the higher potential. However, previously reported material systems had limited success in repeated actuation. In this work, diodes based on Schottky barriers were fabricated by forming metal–semiconductor junctions between titanium and high-resistivity n-type silicon. The performance enhancements were evaluated using current–voltage measurements of interface pairs. When the titanium is coated with gold to limit electrochemical reactions, the Schottky diodes achieved superior performance compared to electrochemical diodes previously studied. Droplet speed range from 8 to 240 mm/s is reported. Under repeated actuation, the speed of the droplet showed no degradation for up to 2000 cycles (experiment duration).
BayesWipe: A Scalable Probabilistic Framework for Improving Data Quality

Recent efforts in data cleaning of structured data have focused exclusively on problems like data deduplication, record matching, and data standardization; none of the approaches addressing these problems focus on fixing incorrect attribute values in tuples. Correcting values in tuples is typically performed by a minimum cost repair of tuples that violate static constraints like Conditional Functional Dependencies (which have to be provided by domain experts or learned from a clean sample of the database). In this article, we provide a method for correcting individual attribute values in a structured database using a Bayesian generative model and a statistical error model learned from the noisy database directly. We thus avoid the necessity for a domain expert or clean master data. We also show how to efficiently perform consistent query answering using this model over a dirty database, in case write permissions to the database are unavailable. We evaluate our methods over both synthetic and real data.
A 6-b DAC and Analog DRAM for a Maskiess Lithography Interface in 90 nm CMOS

A parallel, 12 mum-pitch, low-power 6-b segmented digital-to-analog converter (DAC) array drives an array of 3 mum x 3 mum analog DRAM cells in a 2.5/1 V 90 nm CMOS process, with an application in maskless lithography. An innovative self-calibrating compensation circuit limits the effect of charge leakage and capacitive process mismatch to less than 0.5 LSB over 100 ms of data hold time. A 2 mm x 2 mm test chip implements a mixed-signal interface with 32 DACs driving four 32 times 256 analog DRAM arrays.
Fontan Patient Survival After Pediatric Heart Transplantation Has Improved in the Current Era

Background Historically, patients with a prior Fontan procedure for complex congenital heart disease (CHD) have been considered at higher risk for death after heart transplant (HT) compared with other HT transplant candidates. With the overall trend of improved survival of pediatric HT recipients, it is unclear of Fontan patient post-HT survival has also improved in the current era. Methods Data from the Pediatric Heart Transplant Study database for Fontan patients who underwent HT was compared between the early era (1993 to 2006, n = 150) and late era (2007 to 2014, n = 252). Post-HT survival and pre-HT characteristics were compared among eras and also with non-Fontan CHD patients. Results At time of HT, Fontan patients in the late era were more likely to require inotropic support, have protein-losing enteropathy, have failure to thrive, and be further from time of Fontan, although less likely to be on ventilator support. Only ventilator support and earlier year of HT were significant risk factors for death in the multivariate analysis. Post-HT Fontan patient survival significantly improved from the early to late era ( p = 0.02), particularly in the early phase, with 1-year survival of 77% in the early era and 89% in the late era. Late era non-Fontan CHD patient 1-year post-HT survival was similar to Fontan patients at 92%. Conclusions Survival of Fontan patients after HT has significantly improved in the current era. Currently, expected post-HT survival for Fontan patients is on par with other CHD patients. Fontan patients should not be excluded from consideration for HT solely on a history of Fontan.
Shell-Dependent Photoluminescence Studies Provide Mechanistic Insights into the Off-Grey-On Transitions of Blinking Quantum Dots.

The majority of quantum dot (QD) blinking studies have used a model of switching between two distinct fluorescence intensity levels, “on” and “off”. However, a distinct intermediate intensity level has been identified in some recent reports, a so-called “grey” or “dim” state, which has brought this binary model into question. While this grey state has been proposed to result from the formation of a trion, it is still unclear under which conditions it is present in a QD. By performing shell-dependent blinking studies on CdSe QDs, we report that the populations of the grey state and the on state are strongly dependent on both the shell material and its thickness. We found that adding a ZnS shell did not result in a significant population of the grey state. Using ZnSe as the shell material resulted in a slightly higher population of the grey state, although it was still poorly resolved. However, adding a CdS shell resulted in the population of a grey state, which depended strongly on its thickness up to 5 ML...
In situ made simple: The Planetary Object Geophysical Observer (POGO) power system

Planetary Object Geophysical Observer (POGO) is an M&M®-shaped hopping lander with an integrated payload to measure the composition and temperature of a small planetary body's surface. It is designed to be dropped off by a host spacecraft at the target and conduct a series of random samples by “hopping” around the body's surface. The ability to “hop” is achieved through a unique utilization of a voice coil to provide an upward impulse on the structure of the lander. If POGO lands on an unsuitable measurement location for the instruments, it activates a “shimmy” mode to attempt to reseat the structure in the surface. Thorough testing has been conducted to verify the voice coil can propel POGO provided the gravity of the planetary body and the losses in the regolith are small. The power system on POGO is simple in design but unique in utilization. Since batteries provide the only energy source for POGO, multiple trades and tests have been performed of different cell options. Currently, thorough life testing of various cells is being conducted to ensure the batteries survive the long cruise to the selected planetary body. The voice coil is actuated by discharging a bank of capacitors at high voltage through the voice coil. The capacitor bank is charged up with a charge pump, which is a unique combination of a standard boost converter and a Cockroft-Walton voltage multiplier. The direction of discharge into the voice coil is controlled with a MOSFET H-bridge. The H-bridge is driven with a pair of half-bridge gate drivers which have a floating bootstrap topology for the high side driver. This gives the H-bridge a wide range of capacitor bank operating voltages while providing the fast control necessary for “shimmy” mode. Although there are many benefits to the floating bootstrap topology, there are several drawbacks that must be accounted for in the design and control of the H-bridge.
Assessment of Disability Related to Femoroacetabular Impingement Syndrome by Use of the Patient-Reported Outcome Measure Information System (PROMIS) and Objective Measures of Physical Performance.

Background:The National Institutes of Health (NIH)–sponsored Patient-Reported Outcomes Measurement System (PROMIS) has been described as a valuable tool for characterizing outcomes among patients with specific musculoskeletal conditions. Additionally, previously proposed objective measures of physical performance among patients with nonarthritic hip abnormalities are costly and not practically incorporated into routine clinical practice.Purpose:(1) To determine the ability of the PROMIS to differentiate between patients with femoroacetabular impingement (FAI) and asymptomatic controls, (2) to determine the effect of FAI on subjects’ completion of timed physical performance measures, and (3) to determine whether associations exist between established patient-reported outcome (PRO) measures and subjects’ completion of physical performance measures.Study Design:Cross-sectional study; Level of evidence, 3.Methods:Twenty-two asymptomatic controls (CON group) and 20 patients with FAI completed multiple activiti...
A bout of confusion: Atypical presentations of Anti-Leucine-rich-Glioma-Inactivated 1(LGI-1) encephalitis – an emerging cause of limbic encephalitis (LE) (P5.393)

Objective: Underscore increasing recognition of LGI-1 encephalitis as a cause of LE Report two cases of Anti-LGI-1 encephalitis that presented without the pathognomonic Fascio-Brachial Dystonic Seizures (FBDS) Consider modified diagnostic criteria for anti-LGI-1 Encephalitis. Background: LGI-1 is a trans-synaptic modulator protein that was first identified in 2010 as a target in anti-VGKC autoimmune encephalitis. Anti-LGI-1 encephalitis is now the most common cause of LE (subacute behavioural disturbance, memory loss and focal seizures) amongst the anti-neuronal-cell-surface antibody encephalitides. The relative occurrence of four clinical/laboratory features that are most sensitive for Anti-LGI-1 encephalitis include [1]presenting-as-LE(90%) [2]Bi-temporal-T2-hyperintensities(74%) [3]hyponatremia(65%) [4]normal CSF study(75%). Alhough FBDS is a pathognomonic feature of Anti-LGI encephalitits it is only seen in upto 40% cases. Design/Methods: Case Report Results: We report 2 cases of CSF-antibody positive Anti-LGI-LE without the pathognomonic FBDS. First was was a 35-year-old-woman who presented with 3 weeks of confusion, memory loss and auditory hallucinations, found to have bi-temporal-T2-hyperintensities and a normal EEG study. The second was a 79-year-old-man with 2 weeks of confusion and memory loss who developed a generalised tonic clonic seizure, found to have multiple brief right temporal focal seizures on EEG with an unremarkable MRI brain. Their work up showed normal serum, CSF studies except for mild hyponatremia and were suspected to have Anti-LGI1 encephalitis based on the presence of 3 out of the above 4 features with subsequently positive Anti-LGI1 antibodies detected in the CSF of both patients. Conclusions: Majority of patients with Anti-LGI1 encephalitis will not develop FBDS as noted in our cases. We propose that presence of 3 out of the above 4 features makes anti-LGI-1 encephalitits a likley diagnosis even in the absence of FBDS. Further studies are required to evaluate the sensitivity and specificty of these modified criteria. Disclosure: Dr. Topiwala has nothing to disclose. Dr. Patel has nothing to disclose. Dr Datta has nothing to disclose. Dr. Zhang has nothing to disclose. Dr. Silverman has nothing to disclose.
Meet them in the proximal zone: Introducing framework concepts to “novice learners” using reference sources

S triving to foster critical thinking and metacognition in relation to information literacy is the penultimate goal of instruction librarians. Yet, all effort to do so is futile if students are not being met in their own proximal zone of development. Within the descriptions, knowledge practices, and dispositions of the frames in the Framework for Information Literacy for Higher Education, 1 the “novice learner” is often referenced and compared to the “expert learner.” So while first-year college students begin their journey into higher education with varied levels of experiences in academic research and writing, many are these novice learners referred to within the Framework. Recognizing, and more importantly, accepting where these students are within their own levels of information literacy development can help to determine how to best scaffold instruction by using appropriate teaching tools and pedagogy.
"Restricted Diffusion" within the Splenium of the Corpus Callosum: A Potential Pitfall in Young Infants on 3T Imaging and Marker of Normal Myelin Maturation.

Purpose To determine the prevalence of “restricted diffusion” within the splenium of the corpus callosum (SOCC) on 3 Tesla (T) and 1.5T imaging systems and to establish the contribution of myelin maturation to the presence of “restricted diffusion” within the SOCC. Materials and Methods The imaging database at our hospital was queried to build three cohorts of patients: (1) age Results “Restricted diffusion” within the SOCC was present in 26 of 29 (90%) patients from cohort 1, in 1 of 37 (3%) patients from cohort 2, and in 1 of 35 (3%) patients from cohort 3. There is a significant difference in the prevalence of “restricted diffusion” in the SOCC between the three cohorts of patients. Conclusions “Restricted diffusion” within the SOCC may be a normal finding in infants less than 4 months of age, imaged on a 3T system. The presence of “restricted diffusion” within the splenium may serve as a potential marker of normal brain maturation.
Crossing the western Altiplano: The ecological context of Tiwanaku migrations

Abstract Mobility and migration are critical processes that influence cultural and socio-economic development, and have lasting effects on demographic and ecological arrangements. However, these are ephemeral behaviors which are difficult to reconstruct archaeologically. Here, we employ geospatial approaches to reconstruct mobility corridors likely used by Tiwanaku migrants during the Andean Middle Horizon, ca. AD 500–1000. Prehispanic mobility relied on caravans of Andean camelids. We reconstruct probable mobility corridors while comparing cost- and permeability-based modeling approaches. We further use remote sensing to examine how modern ecological dynamics relate to modeled mobility corridors. Imagery from the Landsat family of multispectral satellites is used to document the response of green vegetation to seasonal and interannual moisture variability. We find that there is a statistically significant increase in the amount of perennially-green vegetation land cover along the corridor linking Tiwanaku with its principal colonial enclaves on the Pacific coast. Such perennially-green vegetation provides a critical resource for prehispanic caravans. The data indicate a relationship between high volumes of migration and enhanced vegetation. We explore whether Tiwanaku migration routes were established in part on the basis of this resource, or if modern land cover reflects an anthropogenic legacy.
SEML: A Simplified English Modeling Language for Constructing Biological Models in Julia

Abstract Many markup languages can be used to encode biological networks, each with strengths and weaknesses. Model specifications written in these languages can then used, in conjunction with proprietary software packages e.g., MATLAB, or open community alternatives, to simulate the behavior of biological systems. In this study, we present the Simplified English Modeling Language (SEML) and associated compiler, as an alternative to existing approaches. SEML supports the specification of biological reaction systems in a simple natural language like syntax. Models encoded in SEML are transformed into executable code using a compiler written in the open-source Julia programming language. The compiler performs a sequence of operations, including tokenization, syntactic and semantic error checking, to convert SEML into an intermediate representation (IR). From the intermediate representation, the compiler then generates executable code in one of three programming languages: Julia, Python or MATLAB. Currently, SEML supports both kinetic and constraint based model generation for signal transduction and metabolic modeling. In this study, we demonstrate SEML by modeling two proof-of-concept prototypical networks: a constraint-based model solved using flux balance analysis (FBA) and a kinetic model encoded as Ordinary Differential Equations (ODEs). SEML is a promising tool for encoding and sharing human-readable biological models, however it is still in its infancy. With further development, SEML has the potential to handle more unstructured natural language inputs, generate more complex models types and convert its natural language markup to currently used model interchange formats such systems biology markup language.
Generation of a Ni3 Phosphinidene Cluster from the Ni(0) Synthon, Ni(η3-CPh3)2

Reaction of NiCl2 in THF with 2 equiv of Li(CPh3) at −25 °C results in formation of Ni(η3-CPh3)2 (1) in moderate yield. Complex 1 was fully characterized, which included analysis by X-ray crystallo...
Gene cloning and expression analysis of trehalose-6-phosphate synthase, glycogen synthase and glycogen phosphorylase reveal the glycometabolism in the diapause process of Aphidius gifuensis

Abstract Aphidius gifuensis is an important biological control agent of aphid. It stores sugar as energy reserves before the onset of diapause, a form of dormancy that occurs when environmental conditions become unfavorable for development. In this study, cDNA of three relevant enzymes, trehalose-6-phosphate synthase (TPS), glycogen synthase (GYS) and glycogen phosphorylase (GP) were cloned, and their expression profiles in the preparation and maintenance of diapause, and post-diapause development were analyzed. The results showed that AgTPS, AgGYS and AgGP encoded proteins consisting of 807, 690 and 844 amino acids respectively. The expression profiles of three genes were significantly affected by diapause-inducing condition. The increase of transcription of AgGYS and AgGP were followed by the up-regulate of AgTPS expression in the preparation of diapause, expression of all three genes were inhibited while diapause is maintained, and expression of AgGYS was up-regulated when diapause was terminated. These results suggested that trehalose is accumulated before initiation of diapause and glycogen may play an important role in post-diapause development.
FerroTag: When Inkables Meet Wireless Signals

Inkjet printed technologies is a type of computer printing that recreates a digital design by propelling droplets of ink onto paper substrates. It is considered a transformative innovation that democratizes the paper-based product fabrication accessible by individual entrants. In recent years, novel functional inks (e.g, nanoparticles-based inks [1]) with consumer inkjet printers enable a more disruptive potential for fabricating low-cost inkable electronics, also known as inkables. Compared with traditional electronics [2], inkables are eco-compatible and easy to use. It is predicted that the market for inkable sensors will reach $4.5 billion by 2030 [3].
Rapid, Spontaneous Resolution of Prominent Subretinal Infiltrate in Vitreoretinal Lymphoma:

Purpose:This case report describes a patient with vitreoretinal lymphoma who subacutely developed a large, peripapillary subretinal infiltrate that rapidly and spontaneously resolved.Methods:A case...
Latent brain state dynamics and cognitive flexibility in older adults.

Abstract Cognitive impairment in older adults is a rapidly growing public health concern as the elderly population dramatically grows worldwide. While it is generally assumed that cognitive deficits in older adults are associated with reduced brain flexibility, quantitative evidence has been lacking. Here, we investigate brain flexibility in healthy older adults (ages 60–85) using a novel Bayesian switching dynamical system algorithm and ultrafast temporal resolution (TR = 490 ms) whole-brain fMRI data during performance of a Sternberg working memory task. We identify latent brain states and characterize their dynamic temporal properties, including state transitions, associated with encoding, maintenance, and retrieval. Crucially, we demonstrate that brain inflexibility is associated with slower and more fragmented transitions between latent brain states, and that brain inflexibility mediates the relation between age and cognitive inflexibility. Our study provides a novel neurocomputational framework for investigating latent dynamic circuit processes underlying brain flexibility and cognition in the context of aging.
Stokes elements on cubic meshes yielding divergence-free approximations

Conforming piecewise polynomial spaces with respect to cubic meshes are constructed for the Stokes problem in arbitrary dimensions yielding exactly divergence-free velocity approximations. The derivation of the finite element pair is motivated by a smooth de Rham complex that is well-suited for the Stokes problem. We derive the stability and convergence properties of the new elements as well as the construction of reduced elements with less global unknowns.
Molecular marker analyses in alfalfa and related species

Alfalfa, Medicago sativa L., a highly productive forage species, grows throughout the temperate regions of the world and produces premium quality hay, silage, and pasturage. Alfalfa originated near the Caspian Sea in northern Iran and northeastern Turkey; its cultivation spread throughout the Mediterranean region and into Germany, France, and China by the time of the Roman Empire (Bolton 1962). Today, alfalfa is raised on all continents and is currently cultivated on more than 32 million hectares worldwide (Michaud et al. 1988). The genus Medicago is highly diverse, including not only perennial, cultivated alfalfa but also several annual forage species and many other species that undoubtedly represent potentially useful germplasm sources for further improvement of the cultivated species.
From the extreme to the mean: Acceleration and tipping points of coastal inundation from sea level rise

Relative sea level rise (RSLR) has driven large increases in annual water level exceedances (duration and frequency) above minor (nuisance level) coastal flooding elevation thresholds established by the National Weather Service (NWS) at U.S. tide gauges over the last half-century. For threshold levels below 0.5 m above high tide, the rates of annual exceedances are accelerating along the U.S. East and Gulf Coasts, primarily from evolution of tidal water level distributions to higher elevations impinging on the flood threshold. These accelerations are quantified in terms of the local RSLR rate and tidal range through multiple regression analysis. Along the U.S. West Coast, annual exceedance rates are linearly increasing, complicated by sharp punctuations in RSLR anomalies during El Nino Southern Oscillation (ENSO) phases, and we account for annual exceedance variability along the U.S. West and East Coasts from ENSO forcing. Projections of annual exceedances above local NWS nuisance levels at U.S. tide gauges are estimated by shifting probability estimates of daily maximum water levels over a contemporary 5-year period following probabilistic RSLR projections of Kopp et al. (2014) for representative concentration pathways (RCP) 2.6, 4.5, and 8.5. We suggest a tipping point for coastal inundation (30 days/per year with a threshold exceedance) based on the evolution of exceedance probabilities. Under forcing associated with the local-median projections of RSLR, the majority of locations surpass the tipping point over the next several decades regardless of specific RCP.
shifting Wittigian binaries: abstraction and re-materialization of the Lesbian body in Sande Zeig's The Girl

This paper explores issues of abstraction and space in Sande Zeig's movie The Girl (2001), based on a novella by Monique Wittig, who also co-wrote the script. It argues that, with this movie, Zeig and Wittig strive to re-materialize the lesbian body abstracted by the ‘Straight Mind’ as defined by Wittig in her 1980 essay. The plot revolves around the love affair of two women, the narrator and the Girl (a lesbian painter and a straight B-grade jazz singer), under the oppressive scrutiny of the Man (the Girl's boss). Each part of this paper corresponds to one space where the characters interact: first, it shows how the nightclub stands as a space of transgression for the lesbian subject and how it opens a reflection on temporality as represented by space; then the analysis of the hotel room where the Girl lives and meets the narrator demonstrates how, notably through the use of close-ups in erotic scenes, Zeig redefines abstraction as a new way to envisage the materiality of the lesbian body; finally, in the third part, the discussion on abstraction moves on to the narrator's studio where, through her work as a painter, she also explores abstract representations of the female body. This approach reconciles Wittigian theory with post-modern queer theory, and confirms that the former still offers paths to positive reformulations of modes of relationality through the de-spatialization of gender – de-genderization; the rematerialization of the body outside of hetero-normative conventions; and a reconfiguration of human relationships that refuses the inevitability of social and amorous hierarchy, and that shifts the representation of the erotic from possessiveness to disinterested reciprocity.
Relationship between stroke volume and sympathetic nerve activity: new insights about autonomic mechanisms of syncope.

Head-up tilt table experiments conducted in astronauts prior to and immediately after the NASA Neurolab Space Mission (STS-90) revealed that a reduction in stroke volume induced by moving from the supine to upright posture was associated with increased muscle sympathetic nerve activity (MSNA). Although this finding was not unexpected, lower average stroke volume and greater average MSNA measured after space flight in both supine and upright postures were positioned in a linear fashion on the same stroke volume-MSNA stimulus-response relationship as the average pre-flight stroke volume and MSNA responses. Since all astronauts who participated in the Neurolab orthostatic experiments completed the 10-min tilt table tests, these observations supported the notion that sympathetic reflex responses were not altered but functioned adequately after space flight in non-presyncopal subjects. In contrast to the Neurolab results, development of orthostatic hypotension and presyncopal events reported in astronauts during standing after space flight have been accompanied by attenuated peripheral vasoconstriction and less elevation in plasma concentrations of norepinephrine. The association between circulating norepinephrine (NE) and peripheral vascular resistance in presyncopal astronauts after space flight led to the conclusion that postflight presyncope can be attributed to a combination of inherently low-resistance responses, a strong dependence on volume status, and relative hypoadrenergic function. In the present investigation, we used graded levels of lower body negative pressure (LBNP) to produce linear reductions in stroke volume and performed direct measurements of MSNA to test the hypotheses that (1) elevations in MSNA during central hypovolemia are proportional (i.e., linear) with reductions in stroke volume and; (2) that the slope of the stroke volume-MSNA relationship will be reduced in presyncopal subjects.
Long atmospheric waves on the sphere and on the polar plane

In earlier studies of long low-frequency atmospheric waves in the polar atmosphere a cyclindrical coordinate system had been used with the planez=0 tangential to the earth's surface at the pole. It had been found by numerical examples that the results obtained with a cylindrical coordinate system approximate quite well those obtained with a spherical coordinate system. Here, it is shown that the formulae for the wave frequencies in both coordinate systems are the same to a good degree of approximation.
Diagnostic biomarkers for Alzheimer's disease using dynamic nonlinear models based on principal dynamic modes

Sensitive and robust diagnostic biomarkers for Alzheimer's disease (AD) were sought using dynamic nonlinear models of the causal interrelationships among time-series (beat-to-beat) data of arterial blood pressure, end-tidal CO 2 and cerebral blood flow velocity collected in human subjects (4 AD patients and 4 control subjects). These models were based on Principal Dynamic Modes (PDM) and yielded a reliable biomarker for AD diagnosis in the form of the “Effective CO 2 Reactivity Index” (ECRI). The results from this initial set of subjects corroborated the efficacy of the ECRI biomarker for accurate AD diagnosis.
Elevated expression of Fn14 in non-small cell lung cancer correlates with activated EGFR and promotes tumor cell migration and invasion

Lung cancer is the leading cause of cancer deaths worldwide; approximately 85% of these cancers are non-small cell lung cancer (NSCLC). Patients with NSCLC frequently have tumors harboring somatic mutations in the epidermal growth factor receptor (EGFR) gene that cause constitutive receptor activation. These patients have the best clinical response to EGFR tyrosine kinase inhibitors (TKIs). Herein, we show that fibroblast growth factor–inducible 14 (Fn14; TNFRSF12A) is frequently overexpressed in NSCLC tumors, and Fn14 levels correlate with p-EGFR expression. We also report that NSCLC cell lines that contain EGFR-activating mutations show high levels of Fn14 protein expression. EGFR TKI treatment of EGFR-mutant HCC827 cells decreased Fn14 protein levels, whereas EGF stimulation of EGFR wild-type A549 cells transiently increased Fn14 expression. Furthermore, Fn14 is highly expressed in EGFR-mutant H1975 cells that also contain an EGFR TKI-resistance mutation, and high TKI doses are necessary to reduce Fn14 levels. Constructs encoding EGFRs with activating mutations induced Fn14 expression when expressed in rat lung epithelial cells. We also report that short hairpin RNA–mediated Fn14 knockdown reduced NSCLC cell migration and invasion in vitro. Finally, Fn14 overexpression enhanced NSCLC cell migration and invasion in vitro and increased experimental lung metastases in vivo. Thus, Fn14 may be a novel therapeutic target for patients with NSCLC, in particular for those with EGFR-driven tumors who have either primary or acquired resistance to EGFR TKIs.
Electron proton resonance of transition metal complexes VII. Epr-approach to lewis acidity of group III halides☆

Abstract Complexes of di-π-cyclopentadienyltitanium chloride (Cp2TiCl) with the trichlorides of Group III elements, having the bridged structure show EPR hyperfine interaction of the unpaired electron of the TiIII with the magnetic nuclei of the Group III elements. The hyperfine pattern of 115In(I = 9 2 ) is reported for the first time. From the isotropic coupling with 11B, 27Al, 69Ga, 71Ga, 115In, the unpaired spin density in the relevant s-orbitals of the Group III elements is estimated. The following series is deduced for the Lewis acidity (electron acceptor ability) of the halides: GaCl3 > BCl3 > AlCl3 > InCl3. The results are considered in the light of published information, and chemical evidence is advanced for the strong acid character of GaCl3.
The aerodynamics of a fluidized bed of ground refractory material

A relationship was obtained for determining the fluidation velocity of milled refractory material. A qualitative assessment is given for firing clays into grog in a fluidized-bed furnace at high temperature. In developing the processes of firing refractory materials in a fluidized bed the industry should move toward a multistage furnace without hearths and regrinding equipment.
Pretreatment with an Inhibitor of Mac-1 Alters Regional and Systemic Platelet Function during Ischemia-Reperfusion in Swine

Myocardial ischemia-reperfusion alters regional and systemic platelet function. The aim of our study was to elucidate the role of the Mac-1 receptor in changes of platelet function by using the leumed
Gay Adolescent Males’ Effective Coping with Discrimination: A Qualitative Study

In addition to developmental stressors that all adolescents face, lesbian, gay, and bisexual (LGB) youth must also deal with stressors associated with anti-LGB prejudice, discrimination, and stigma. Little is known about the specific ways in which LGB youth cope with the anti-LGB incidents in their everyday lives or what might constitute “effective” coping in this context. In the current exploratory study, the authors present findings and implications based on interviews with eight gay-identified male adolescents. Eight distinct coping strategies that were viewed as successful by participants were identified. Implications for counselors and future extensions of this research are discussed.