cssi/SciSciGPT-SciSciNet huggingface dataset:
Women Living with HIV over Age of 65: Cervical Cancer Screening in a Unique and Growing Population.

Objective. Women living with HIV are at increased risk of human papillomavirus (HPV) infection, which can lead to cervical cancer. New guidelines recommend indefinite screening. The objective of this study is to describe cervical cancer screening practices and colposcopy results in a cohort of women living with HIV over age of 65 who were followed before the new guidelines. Comorbidities, sexually transmitted infections (STIs), and other risk factors were evaluated. Methods. We conducted a retrospective chart review on 75 women aged 65 or older living with HIV with at least one Pap smear. Results. The mean age of the cohort was 66.5 and at HIV diagnosis was 56. The majority of women were immunocompetent. 80% had serial Pap smears. Of these, 86% of 238 were negative or ASCUS. No women progressed to HSIL. 92% of colposcopies had negative or CIN I results. Three women were treated successfully for high-grade dysplasia. More than half of women had other STIs. 72% were screened for HPV; 50% were positive. Conclusion. The majority of women had negative and low-grade Pap smears. Questions remain regarding the utility of continued Pap screening and the added value of HPV testing in this unique population of older women living with HIV.
Financial Ratios in Empirical Corporate Finance Research

This paper provides guidance on the appropriate estimation of financial ratios for empirical research corporate finance, corporate governance and accounting. Practical examples are provided employing the widely-used Compustat database, and all calculated ratios are made available for download in a dataset. A companion Github repository of the associated SAS code is offered to assist researchers in estimating key financial ratios consistently.
An approach to detect and mitigate neural disorders using swarm of bionanomachines

In this paper, we focus on the possibilities of using bionanomachines to treat neuronal (brain) disorders. Neuronal networks in the brain are an excellent example of nanonetworks that control all major functions of a human body, thereby offering a sound physical and mental health of a human being. In the brain, approximately one hundred billion neurons are connected three-dimensionally with other neurons in order to form immensely complex neuronal nanonetworks. Therefore, there are trillions of connections that exist among neurons in the brain. When neurons get damaged due to disease or accidents, they affect specific human body functions. It has been found that bionanomachines could interact with neurons in brain nanonetworks and thus help treat brain disorders. This paper describes an approach to detect and remedy neural disorders using bionanomachines. We propose the deployment of a swarm of bionanomachines in the brain that can collectively detect synaptic dysfunctions and mitigate it by injecting excitatory therein. Combinatorial enumeration is explored as a potential tool that can allow us to characterize the requirements on detection capabilities of a single nanobiomachine, as well as of the swarm.
Calculation of Admittance Transfer Functions Using Manual Symbolic Suspendance Analysis

This paper introduces a new manual symbolic analysis for the calculation of admittance transfer functions. Suspendance terms are expressed in terms of circuit admittances and transadmittances. The admittance transfer function at each node of a circuit is equal to the ratio of the suspendance obtained when the node is open to the suspendance obtained when the node is shorted. To calculate the suspendance for each case, every passive circuit component is shorted one at a time and its admittance is multiplied by the suspendance of the remaining circuit. Admittances of previously shorted components are set to zero in succeeding calculations. The overall suspendance is calculated by summing all individual results obtained from each step. In comparison with all existing circuit analysis methods, suspendance calculation is easier, faster, and more practical.
Adoptive immunotherapy with haploidentical natural killer cells and Anti-GD2 monoclonal antibody m3F8 for resistant neuroblastoma: Results of a phase I study.

Natural killer (NK) cell-mediated antibody-dependent toxicity is a potent mechanism of action of the anti-GD2 murine monoclonal antibody 3F8 (m3F8). Killer immunoglobulin-like receptor (KIR) and HLA genotypes modulate NK activity and are key prognostic markers in m3F8-treated patients with neuroblastoma. Endogenous NK-cells are suppressed in the setting of high tumor burden and chemotherapy. Allogeneic NK-cells however, demonstrate potent anti-neuroblastoma activity. We report on the results of a phase I clinical trial of haploidentical NK-cells plus m3F8 administered to patients with high-risk neuroblastoma after conditioning chemotherapy. The primary objective was to determine the maximum tolerated NK-cell dose (MTD). Secondary objectives included assessing anti-neuroblastoma activity and its relationship to donor-recipient KIR/HLA genotypes, NK function, and donor NK chimerism. Patients received a lymphodepleting regimen prior to infusion of haploidentical CD3-CD56+ NK-cells, followed by m3F8. Overall and progression free survival (PFS) were assessed from the time of first NK-cell dose. Univariate Cox regression assessed relationship between dose and outcomes. Thirty-five patients received NK-cells at one of five dose levels ranging from 10×106 CD56+cells/kg had improved PFS (HR: 0.36, 95%CI: 0.15-0.87, p = 0.022). Patient NK-cells displayed high NKG2A expression, leading to inhibition by HLA-E-expressing neuroblastoma cells. Adoptive NK-cell therapy in combination with m3F8 is safe and has anti-neuroblastoma activity at higher cell doses.
Learning against opponents with bounded memory

Recently, a number of authors have proposed criteria for evaluating learning algorithms in multiagent systems. While well-justified, each of these has generally given little attention to one of the main challenges of a multi-agent setting: the capability of the other agents to adapt and learn as well. We propose extending existing criteria to apply to a class of adaptive opponents with bounded memory. We then show an algorithm that provably achieves an o-best response against this richer class of opponents while simultaneously guaranteeing a minimum payoff against any opponent and performing well in self-play. This new algorithm also demonstrates strong performance in empirical tests against a variety of opponents in a wide range of environments.
The CVD of Metals

This chapter reviews the materials that are deposited by chemical vapor deposition (CVD) either on a production basis or experimentally. These materials include metals such as: aluminum, beryllium, chromium, and copper. The testing conditions and other factors influence the results such as: the processing conditions, composition and stoichiometry, impurities like oxygen and nitrogen, grain size and morphology, grain orientation, structural defects like vacancies, dislocations, and the presence of different phases. Aluminum is a light metal characterized by a low melting point and high electrical conductivity. The deposition of aluminum by the metallo-organic chemical vapor deposition (MOCVD) process is useful because of the good conformal coverage it offers. The CVD of aluminum is an important factor in semiconductor manufacturing. Aluminum can be deposited by the decomposition of an alkyl precursor with ultraviolet (UV) laser or with an argon-ion laser in applications such as patterns and lithography. The metals discussed play an important part in the fabrication of integrated circuits and other semiconductor devices in optoelectronic and optical applications, in corrosion protection, and in the design of structural parts.
Inconsciente genérico, feminismo y Nubosidad variable de Carmen Martín Gaite

In a context of marked tensions between gynocritics and contemporary Spanish women writers, Carmen Martin Gaite’s novel Nubosidad variable (Variable Cloud,1992) stands out as a curious paradox. As is well known, Martin Gaite repeatedly declared not to be a feminist and even scorned women who fought for equality between both sexes. This article argues that Nubosidad variable, however, constitutes one of the best examples of a consciously feminist text. In this novel Martin Gaite applies some of the most prominent paradigms of feminist literary theory, such as the construction of a non-linear and a-chronological narration (Julia Kristeva), the attempt to create a “language of the body” (Helene Cixous), the foregrounding of a mother-daughter bond (Luisa Muraro), as well as the use of female writing as a means of self-discovery (Elaine Showalter).
The Use of Animal Models to Study Diabetes and Atherosclerosis and Potential Anti-Atherosclerotic Therapies

Epidemiological studies have documented that individuals with diabetes mellitus (DM) and those with impaired glucose tolerance (IGT) have an increased prevalence of atherosclerosis and increased rates of coronary artery disease (CAD) (1,2). However, the mechanisms by which these conditions enhance atherogenesis are poorly understood. Hyperglycemia, the defining metabolic change in diabetes, may contribute to the development of atherosclerosis. However, the specific contribution of hyperglycemia has been difficult to demonstrate in either population studies or in animal models (1,3, 4, 5, 6). Moreover, hyperglycemia per se is unlikely to play a role in the development of atherosclerosis in individuals with IGT who usually demonstrate only modest postprandial hyperglycemia. This is confirmed by recent data from the United Kingdom Prospective Diabetes Study demonstrating that improved glucose control reduces microvascular complications, but has modest or no effects on macrovascular disease and its clinical sequelae (3). Many investigators have therefore suggested that other factors besides glucose levels contribute to the development of macrovascular disease in diabetes. On the other hand, insulin resistance, an essential component of type 2 diabetes, is frequently associated with a number of metabolic abnormalities such as hypercholesterolemia, hypertriglyceridemia, low high-density lipoprotein (HDL), and hypertension that are considered “traditional” risk factors for atherosclerosis. However, these risk factors explain only some, but not all of the increased risk for CAD in individuals with IGT or diabetes (7,8). Thus, additional factors associated with insulin resistance and diabetes are likely to contribute to the development of atherosclerosis (Table 1).
The Concept of “Risk” in Infant and Early Childhood Neuropsychology

An important issue in early developmental neuropsychology is the concept of “risk.” Tjossem (1976) delineated three categories of risk: established, environ- mental, and biological. Established risks are medical disorders of a known etiology whose developmental outcome is well documented (e.g., Down syndrome, HIV). Environmental risks include the quality of the mother—infant interaction, opportunities for developmental/cognitive stimulation, and health care. Biological risks include the exposure to potentially noxious prenatal, perinatal, or postnatal developmental events such as asphyxia, intraventricular hemorrhage, and low birth weight (LBW). [LBW is ≤2500 g, very low birth weight (VLBW) is ≤1500 g, and extremely low birth weight (ELBW) is ≤1000 g.] There is increasing interest in infants with birth weights ≤ 800 g (1 lb, 1 oz), who are considered to be at extreme biological risk. Practitioners in infant and early childhood neuropsychology must consider all three categories of risk, with young patients often having more than one type. Although there is continued emphasis on medical factors being causative agents in compromised developmental outcome (Weisglas-Kuperus, Baerts, Smrkovsky, & Sauer, 1993), the importance of environmental risks on later functioning is increasingly recognized (Aylward, 1990, 1992, 1996; Bradley, Whiteside, Mundfrom, & Blevins-Kwabe, 1995).
Immune cell surface proteins from tumor samples to predict patient clinical outcome.

e15630Background: The incidence and mortality of Hepatocellular carcinoma (HCC) are rapidly increasing in the US. Treatments for advanced HCC are limited despite best efforts to develop therapeutic...
A MULTI-COMPONENT SYSTEM FOR DATA ACQUISITION AND VISUALIZATION IN THE GEOSCIENCES BASED ON UAVS, AUGMENTED AND VIRTUAL REALITY

Abstract. In this age of computer gaming, portable device video and high definition entertainment, students are exposed to sophisticated graphics and virtual reality every day. As a result, students arrive at universities with a high level of expectation and experience in visualization and 3D graphics. Traditional materials for education and outreach rely predominantly on two-dimensional displays of maps, photographs, data graphs/histograms and conceptual diagrams. Advances in geospatial technologies, including unmanned aerial systems and virtual/ augmented reality devices can be used to enhance and innovate instructional materials in classrooms from pre-K to graduate degree programs. This work reports on these technologies and the integration of the 3D Immersion and Geovisualization (3DIG) system at the Center for Geospatial Research at the University of Georgia, USA. We present system components, lessons learned during design and implementation of the system, and the incorporation of 3DIG into teaching, learning and research. Data flow is used as a multi-component system integrator and shows how interconnected and complementary technologies can provide hands-on and immersive experiential learning to students in the geosciences. System evaluation shows increased student interest/engagement and indicates that 3DIG facilitates the understanding of complex concepts.
Supporting Instructional Transformation Tied to Standards-Based Reforms: Examining a Learning-Focused Approach to Supporting School-Wide Implementation.

Across many international contexts, more recent standards-based and other educational reforms have largely intended to transform teaching. Given the importance of teacher learning to such transform...
A Forensic Pattern-Based Approach for Investigations in Cloud System Environments

Unified Communications (UC) is revolutionizing next generation enterprise networks by allowing human voice and video to travel over existing packet data networks along with UC services such as video teleconferencing (VTC), unified messaging, and chat. The ultimate goal for UC is an integrated, fully-converged, cloud-based architecture. The implementation of this technology brings new forensic challenges to network investigators. Recently, a cloud service delivery model known as UC as a Service (UCaaS) is gaining momentum in the field of Information Technology. This paper discusses the main challenges associated with forensic investigations in an UC cloud environment. Further, this research attempts to improve UC security by proposing two semi-formal patterns in order to create a Cloud Forensic Model. These patterns provide a systematic approach to network forensic collection and analysis of digital evidence in UCaaS architectures. The proposed cloud forensic framework will allow network investigators to specify, analyze and implement network forensic investigations for technologies under the UC umbrella.
The just price, exploitation, and prescription drugs: why free marketeers should object to profiteering by the pharmaceutical industry

Many people have been enraged lately by the enormous increases in certain generic prescription drugs. But free marketeers defend these prices by arguing that they simply represent what the market w...
Modeling of Transcranial Magnetic Stimulation Versus Pallidal Deep Brain Stimulation for Parkinson’s Disease

Non-invasive repetitive transcranial magnetic stimulation (TMS) is a neuromodulation technique in which time-varying magnetic fields induce electric fields on the patient’s brain, thus stimulating neurons in the targeted cortical region. We have created a new model of the basal ganglia motor pathway in the human brain, using the Python package called NEST. We simulated healthy nuclei with random noise and connection weights optimized to mimic established background neuronal activity noise in the connecting nuclei. We then simulated Parkinsonism by removing dopaminergic (DAergic) input from the substantia nigra pars compacta to the striatum. The results showed the production of characteristic Parkinsonian neuronal features, ranging from pathological highly irregular to burst signals matching those found during in vivo animal and human microelectrode recording studies. With the model thus validated, we modeled deep brain stimulation (DBS) current delivery to the globus pallidus internus (GPi) in a Parkinsonian brain and simulated neuron firing as an effect of DBS. Finally, repetitive TMS at various frequencies was simulated at the level of the motor cortex, which produced predicted downstream firing rate effects and intra-neuronal synchrony at the level of the GPi. Although typical clinical TMS at 10 pulses/s was suggested to offer some beneficial effects, firing rates and patterns and desynchronous firing were most effectively normalized to match those seen in a healthy GPi upon stimulation at 50 pulses/s. Thus, our modeling suggests that cortical, non-invasive TMS may be a viable alternative to DBS surgery for patients with Parkinson’s disease (PD).
Might there be a medical conscience

I defend the feasibility of a medical conscience in the following sense: a medical professional can object to the prevailing medical norms because they are incorrect as medical norms. In other words, I provide an account of conscientious objection that makes use of the idea that the conscience can issue true normative claims, but the claims in question are claims about medical norms rather than about general moral norms. I further argue that in order for this line of reasoning to succeed, there needs to be an internal morality of medicine that determines what medical professionals ought to do qua medical professionals. I utilize a constructivist approach to the internal morality of medicine and argue that medical professionals can conscientiously object to providing treatment X, if providing treatment X is not in accordance with norms that would have been constructed, in light of the end of medicine, by the appropriate agents under the appropriate conditions.
Imaging of Stress Fractures

Stress-induced injuries are common in athletes. Symptomatic individuals constitute a significant proportion of patients who are evaluated in a typical sports medicine practice. Imaging is an important component of the overall assessment of these patients and contributes vital information that influences not only the course of treatment but that is also predictive for the time off from play before the athlete is allowed to reengage in the athletic activity. In this chapter, a comprehensive review of the available imaging modalities in the radiology armamentarium will be discussed, and how they may be most optimally employed in the assessment of stress fractures.
Abstract 2538: p53 activation induces cell cycle arrest by promoting DREAM and RB repression of cell cycle genes

p53 activation results cell cycle arrest at the G1/S checkpoint and the repression of early (G1/S) and late (G2/M) cell cycle gene expression in a p21 dependent manner. The mechanism how p53 and p21 repress cell cycle gene expression is unclear. p21 is known to repress CDK2 which is a key inhibitor of the pocket protein family members RB and p130. During a normal cell cycle, p130 as part of the DREAM complex (DP1, RB-like p130, E2F4, and MuvB) and RB cooperate to repress expression of early (G1/S) and late (G2/M) cell cycle gene expression. DREAM binds and represses late (G2/M) cell cycle promoters through MuvB binding and early (G1/S) cell cycle promoters though repressor E2F binding. RB is only able to bind and repress early (G1/S) cell cycle promoters through its interaction with activator E2Fs. The requirement for DREAM and RB for control of cell cycle gene expression after p53 activation was unknown. We hypothesized that DREAM and RB would cooperate to repress cell cycle gene expression after DNA damage. Using primary human foreskin fibroblast cells lacking RB and/or p130, we found repression of early and late cell cycle gene expression is differentially regulated after p53 activation. We found that while RB is required for repression of early (G1/S) cell cycle genes after p53 activation, DREAM is required for repression of expression of late (G2/M) cell cycle genes. Surprisingly, DREAM was unable to repress early cell cycle genes after p53 activation, suggesting that RB is the key regulator of G1/S gene expression during cellular stress like DNA damage. Further, the requirement for DREAM to repress late cell cycle gene expression underlies the importance of DREAM to prevent expression of mitosis inducing genes in a state like DNA damage when mitosis could result in propagation of mutated DNA. We found that p107, a protein reported be able to replace p130 in DREAM, does not potently repress early cell cycle genes in HFFs under contact arrest and serum starvation. However, we found that p107 strongly represses expression of late cell cycle genes during G0 in cells lacking p130 alone or in combination with RB. These data provide evidence for a specific role for p107-DREAM not previously appreciated. Together, our data show that control of cell cycle gene expression after p53 activation is split in two: RB represses early cell cycle genes while DREAM represses late cell cycle genes. Citation Format: Amy E. Schade, Martin Fischer, James A. DeCaprio. p53 activation induces cell cycle arrest by promoting DREAM and RB repression of cell cycle genes [abstract]. In: Proceedings of the American Association for Cancer Research Annual Meeting 2019; 2019 Mar 29-Apr 3; Atlanta, GA. Philadelphia (PA): AACR; Cancer Res 2019;79(13 Suppl):Abstract nr 2538.
Are On-Demand Platforms Winner-Take-All Markets?

On-demand platforms such as Uber, Caviar and TaskRabbit are a key engine of growth in the digital economy, bringing together time-sensitive customers and independent service providers. The existenc...
Screen-Printed Soft-Nitrided Carbon Electrodes for Detection of Hydrogen Peroxide.

Nitrogen-doped carbon materials have garnered much interest due to their electrocatalytic activity towards important reactions such as the reduction of hydrogen peroxide. N-doped carbon materials are typically prepared and deposited on solid conductive supports, which can sometimes involve time-consuming, complex, and/or costly procedures. Here, nitrogen-doped screen-printed carbon electrodes (N-SPCEs) were fabricated directly from a lab-formulated ink composed of graphite that was modified with surface nitrogen groups by a simple soft nitriding technique. N-SPCEs prepared from inexpensive starting materials (graphite powder and urea) demonstrated good electrocatalytic activity towards hydrogen peroxide reduction. Amperometric detection of H2O2 using N-SPCEs with an applied potential of −0.4 V (vs. Ag/AgCl) exhibited good reproducibility and stability as well as a reasonable limit of detection (2.5 µM) and wide linear range (0.020 to 5.3 mM).
The Technical Committee on Musical Acoustics: Integral part of the interdisciplinary nature of acoustics

The Technical Committee on Musical Acoustics (TCMU) of the Acoustical Society of America (ASA) is concerned with the application of science and technology to the field of music. Traditionally, the areas of interest for those doing musical acoustics have included: the physics of musical sound production, questions of music perception and cognition, and the analysis and synthesis of musical sounds and composition. It is clear that many of the technical committees of the ASA are highly interdisciplinary and TCMU is no exception. The TCMU organizes special sessions often featuring a family of musical instruments, a style of music, or a technique of musical performance. Additionally, sessions have featured innovative techniques for studying acoustics which have broad application across the other technical committees. TCMU also regularly hosts musical performances at ASA meetings and visits to local music venues or musical instrument factories in order to connect researchers to practitioners. The TCMU encourages all members of the ASA to engage with us in the pursuit of understanding the production, radiation, perception, and cognition of musical sounds.The Technical Committee on Musical Acoustics (TCMU) of the Acoustical Society of America (ASA) is concerned with the application of science and technology to the field of music. Traditionally, the areas of interest for those doing musical acoustics have included: the physics of musical sound production, questions of music perception and cognition, and the analysis and synthesis of musical sounds and composition. It is clear that many of the technical committees of the ASA are highly interdisciplinary and TCMU is no exception. The TCMU organizes special sessions often featuring a family of musical instruments, a style of music, or a technique of musical performance. Additionally, sessions have featured innovative techniques for studying acoustics which have broad application across the other technical committees. TCMU also regularly hosts musical performances at ASA meetings and visits to local music venues or musical instrument factories in order to connect researchers to practitioners. The TCMU encourage...
Emoji Face Renderings: Exploring the Role Emoji Platform Differences have on Emotional Interpretation

Emoji faces are ubiquitous and integrated into most people’s everyday (nonverbal) vernacular. Yet, we know little about how people interpret these characters in terms of their emotional content. Do people agree that an emoji face represents an individual emotion and that it is unique to a specific emotion? Are such representations similar across electronic platforms? The present study took a theoretical approach to address these questions by investigating shared agreement between emoji–emotion pairings across three electronic platforms (Apple, Android, and Samsung). Two hundred twenty-eight English-speaking adults completed an online survey that involved picking up to three emoji faces (presented from a common set from one of three platforms) for each of 10 emotions. They then indicated the strength of that relationship. We examined whether the intensities that participants gave to emoji–emotion pairings were specific and consistent across platforms. Our results showed limited shared agreement for the majority of emoji–emotion pairings, and significant variation as to which emotion category a “comparable” emoji belonged depending upon the viewed platform. We highlight the need for future emoji perception research to examine how different platform renderings of the same emoji might lead to miscommunication and interpretation discrepancies.
Cochlear Implant Mapping Through Telemedicine-A Feasibility Study.

Objective Access to postoperative aural rehabilitation limits cochlear implant (CI) penetration to the candidate population. The purpose of this study was to evaluate the effectiveness of remote CI programming and aural rehabilitation via telehealth. Study design and setting Retrospective study of one cochlear implant center. Patients and intervention Patients undergoing cochlear implantation from 2015 to 2018 undergoing remote programming as part of routine audiologic follow up. Main outcome measures AzBio scores, impedances, comfort and threshold levels, and responses to the International Outcome Inventory for Hearing Aids questionnaire modified for CIs (IOI-CI). Results A total of 22 CIs in 20 patients were included during the study period. Threshold, comfort, and impedance levels were readily obtained via telehealth and were not significantly different between telehealth and live sessions. AzBio scores and warble tone pure tone averages were also similar and acceptable in both session modalities. Based on IOI-CI scores, patients were very satisfied with their hearing outcomes. Conclusions Using telemedicine, reliable measurements were readily obtained and hearing outcomes after remote programming were comparable to those expected after in-person programming sessions. Patients were overall satisfied with their remote programming sessions. Telehealth is a cost-effective and safe way to deliver post-CI audiologic care, particularly to patients with limited mobility or those in remote locations.
Load-Frequency Effect on Fatigue Life of IMP6/APC-2 Thermoplastic Composite Laminates

Load-frequency effect on fatigue life of a thermoplastic and toughened BMI composite was investigated. Experimental results were obtained using three frequencies at two load levels with three types of laminates, each containing a center hole. Besides fatigue life, the temperature history near the hole and the specimen stiffness were monitored. In addition, the hysteresis loop was recorded at various stages of the fatigue test to observe the variation in viscoelastic property of the specimen. From the fatigue test results, it was found that fatigue life of matrix-dominated thermoplastic composite laminates decreased as load frequency increased. This behavior is opposite to that of epoxy-based fiber composites. For fiber-dominated thermoplastic laminates under tension-compression load, very low load-frequencies (less than 0.4 Hz) could significantly lower their fatigue life. Analytical models were developed to account for the load-frequency effect on fatigue life of thermoplastic composites. Temperature rise near the hole was included in the model to account for temperature effect.
Coastal Resources of Bocas del Toro, Panama: Tourism and Development Pressures and the Quest for Sustainability: edited by D. O. Suman and A. K. Spalding. University of Miami: Coral Gables, FL. 2018. 263 pp. (This publication is available without charge).

The first time I visited the Archipelago of Bocas del Toro was in 2004. I crossed the sketchy bridge over the Sixaola River between Costa Rica and Panama to take a taxi. The taxi driver drove me th...
Efficacy and utility of robotic single-access bilateral nephrectomy (r-SABN) in end-stage renal disease patients

Bilateral native nephrectomies are needed in ESRD patients with select indications in a pre-transplant setting. Yet, the perioperative morbidity is significant in this population. Herein we evaluate the efficacy and utility of r-SABN. A total of 12 patients were consented at a single center. Of 12 patients, 3 patients did not meet study criteria and were excluded. Preoperative, perioperative, and postoperative data were prospectively collected from 9 patients from electronic health records and administered postoperative surveys. Patients were assessed at 30–180 days postoperatively for follow-up. Mean operative time was 204.3 ± 59.7 min (142.0–314.0) and estimated blood loss during operation was 94.4 ± 87.3 ml (25.0–300.0). The mean length of hospital stay was 2 ± 0.7 days (1–3) for all patients. Total post-operative opioid usage was normalized to morphine dose equivalents (MDE) and calculated to be 56.1 ± 30.4 mg (30.8–101.8). Patients experienced a fourfold and tenfold respective increase in weekly structural and incidental physical activity from 30 to 180 days postoperatively. There were no procedure related intraoperative or postoperative complications reported in the cohort. Overall, r-SABN afforded the patients low morbidity. Longitudinal studies are in progress to further assess the efficacy and outcome of this procedure. In a single-center study, we demonstrate r-SABN is viable and provides a novel tool for treatment of ESRD patients requiring this procedure.
Multidisciplinary Management of an Aorto-esophageal Injury Caused by Foreign Body Ingestion.

A 37-year-old incarcerated male ingested a complex “X-shaped” foreign body that resulted in a penetrating aorto-esophageal injury. A primary esophagotomy with retrieval of the foreign body and muscle flap closure was performed simultaneously with thoracic endovascular aortic repair. This multidisciplinary surgical approach controls for both immediate exsanguination and postoperative complications to improve patient outcome.
States, the PPP, and Planning for Fiscal Shocks

This article addresses the Paycheck Protection Program and the federal and state tax treatment of funds received by taxpayers under that program. The article explains whether and how the PPP has affected state tax revenues and evaluates how potential federal changes to the deductibility of expenses funded by PPP funds would further impact states and their tax revenues. The article concludes by suggesting attention to this then-latent fiscal shock and to state-tax conformity practices more generally.
Renewal and Return to the Center

In a 2004 essay, "What Coyote and Thales Can Teach Us: An Outline of American Indian Epistemology,” Brian Yazzie Burkhart suggests an educational value of the natural world, noting that "the most important things to keep in mind are the simple things that are directly around us in our experience,” and that "truth ... and meaning and value arise in the intersection between us and all that is around us.” Burkhart offers these insights in an essay dedicated to showing ways in which Native American philosophy differs from Western philosophy. My paper, while maintaining a respect for that difference, approaches the work of two 19th-century Western thinkers”Schelling and Emerson”through a framework suggested by Burkhart and other Native American philosophers. I do so with the aim of bringing to the foreground possibilities for contemporary environmental philosophy. The central focus of the paper is the educational value of our interactions with nature: the ways in which our self-understanding”and along with it, our moral disposition”might be transformed through our interactions with the natural world. Schelling and Emerson have each been acknowledged for the ways in which their work prefigures contemporary environmentalism, and indigenous American worldviews are recognized for their prospects of rehabilitating our relationship to nature. This paper argues for a renewed sense of self in nature emerging from the contributions of all three.
HIDING IN PLAIN SIGHT: NEW EVIDENCE ABOUT THE BIRTH, IDENTITY, AND STRATEGIC PSEUDONYMS OF JOHN JAMES AUDUBON

John James Audubon, the self-trained artist and naturalist, is best known for The Birds of America. Although his life has been widely studied in biographies, his birth mother and the confusing series of names assigned to him during the early decades of his life have never been satisfactorily explained, leading to many misconceptions and controversies. New documentary evidence, including an important unpublished letter, allows us in the first part of this article to connect the historical dots to firmly establish his ancestry and to counter misunderstandings about it. The documents analyzed in the second part clear up the mysteries surrounding his early identities and pseudonyms, which prove to have been both intentional and strategic, and also underline that Jeanne Rabine was his mother. In the process, the study will also illuminate elements in the large cache of Audubon's early ornithological pastels and the manuscript of his earliest autobiography held by the Ernst Mayr Library and Archives of the Museum of Comparative Zoology and Houghton Library of Harvard University.
VENTURE CAPITAL AND IPO LOCKUP EXPIRATION: AN EMPIRICAL ANALYSIS

Most initial public offerings (IPOs) feature “lockup” agreements, which bar insiders from selling the stock for a set period following the IPO, usually 180 days. We examine stock price behavior in the period surrounding lockup expiration for a sample of 2,529 firms from 1988 to 1997. We find that lockup expirations are, on average, associated with significant and negative abnormal returns, but the losses are concentrated in firms with venture capital backing. For the venture-capital-backed group, the largest losses occur for high-tech firms and firms with the greatest post-IPO stock price increases, the largest relative trading volume in the period surrounding expiration, and the highest quality underwriters. JEL classification: G14, G24
Post-Ablation Tubal Sterilization Syndrome: Does Route of Sterilization Matter?

Abstract Objective To compare the prevalence of clinical post-ablation tubal sterilization syndrome among women who underwent abdominal (i.e. peripartum or laparoscopic) vs. hysteroscopic permanent contraception in addition to endometrial ablation. Study Design This study was a retrospective cohort study conducted at an academic medical center. We included women (N=188) who successfully underwent both endometrial ablation and permanent contraception between 2005 and 2017. Forty-one women underwent hysteroscopic permanent contraception and 147 underwent abdominal (i.e. peripartum or laparoscopic) permanent contraception. The primary outcome was the prevalence of clinical post-ablation tubal sterilization syndrome, as defined by new or worsening cyclic pelvic pain after completion of both procedures. Results The overall prevalence of the syndrome was 19.1% (34 of 178 women who followed up), with no detected difference between those who underwent hysteroscopic (six out of 38, 15.8%) vs. abdominal permanent contraception (28 out of 140, 20.0%, p=0.55). In multivariate regression modeling, when adjusted for race, parity, gynecologic pathologies, hormonal medication use, and the presence of baseline pain (both pelvic and non-pelvic) only younger patient age was marginally associated with increased odds of the syndrome (aOR 1.85, 95% CI 1.01-3.45, p=0.05), while abdominal as compared to hysteroscopic permanent contraception was not (aOR 1.29, 95% CI 0.59-2.84, p=0.53). Of the 28 patients with clinical post-ablation tubal sterilization syndrome who underwent hysterectomy and/or salpingectomy as treatment for their pain, none showed signs of hematosalpinx or hematometra at the time of surgery or on final pathology. Conclusion We did not find evidence that route of permanent contraception affects the risk of post-ablation tubal sterilization syndrome development. Younger patients may be at higher risk of this syndrome.
Running Water in Clarice Lispector's The Besieged City

When, in Clarice Lispector's The Besieged City (1949), our protagonist, Lucrecia, contemplates her relationship with the city of Sao Geraldo, she pays special attention to water and water infrastructure. Pipes and embankments and viaducts, even the humble faucet – all of this technology of controlling and delivering water becomes a way of conceptualizing the city, but waterworks, I argue, is also an integral part of the text's experiment with vision. Can one see what is there? Can one see the "thing" liberated from our vocabularies? In Chapter 6, in which, supposedly, nothing is happening, Lucrecia is at the faucet, doing the dishes, losing her sense of self as she communes with the city. Later, when she notices a broken faucet in the storeroom, she confronts the thingness of this piece of equipment. To realize the thingness of herself is her most powerful desire. My analysis attempts to complicate feminist readings of The Besieged City by arguing that the text imagines objectification not as a problem, but as a paradoxical attempt at agency. Previous readings approach Lispector's novel as a condemnation of the city; my analysis understands The Besieged City as a representation of the modern sublime.
The Steel Dog in the Canadian Arctic: A Historical Case Study of Technological Change

During the "Snowmobile Revolution" of the late 1960s, the snowmobile largely supplanted the dog team as the main form of transport in the Canadian Arctic. This essay draws from historical and ethnograpphic sources to investigate practical advantages and disadvantages to adoption of the new technology, and then considers whether this episode of rapid technological change resulted in "cultural loss" in Arctic communities. While it is clear that widespread adoption of the snowmobile technological complex (machines, fuel, tools, skills, knowledge) caused significant changes in life in the Far North, it also appears that the meanings and values associated with traditional subsistence hunting were generally not lost, and in some cases were reinforced during this period of technological transition. Finally, drawing on various academic traditions such as the Social Construction of Technology school, ecological models of convergent cycles, postmodern critiques of modernization and development, and the appropriate technology movement, the essay then questions simplistic notions of cultural loss by considering the common evolution of culture and technology.
A new species of Ceratosolen from the Philippines (Hymenoptera: Agaonidae)

A new species of fig wasp, Ceratosolen (Ceratosolen) polyodontos n. sp., is described from females captured at Los Banos, Luzon, Philippines. The species can be distinguished from its congeners by the possession of a much greater number of ventral mandibular lamellae (22-23), divided into an anterior and posterior area, and posterior metasomal structures associated with the ovipositor.
Reports and Comments on Proposed ABA Interpretation 301-6

The ABA Section of Legal Education and Admission to the Bar has proposed to add Interpretation 301-6 of its Standards and Rules of Procedure for Approval of Law Schools. Interpretation 301-6 would impose Bar-based outcome measures of the quality of a law school's academic program. This paper collects letters or reports submitted by the author to the ABA that comment on each of the three versions of 301-6 proposed to date. These comments not only provide an empirical evaluation of 301-6, they also suggest changes to 301-6.
Adenylate kinase activity in ejaculated bovine sperm flagella.

Abstract Adenylate kinase (ATP:AMP phosphotransferase, EC 2.7.4.3) activity was detected in the flagella of ejaculated bovine spermatozoa. This activity provided sufficient ATP to produce normal motility in cells permeabilized with digitonin and treated with 0.5 mM MgADP. In the presence of ADP, adenylate kinase activity was inhibited by P1,P5-di(adenosine 5')-pentaphosphate (Ap5A), an adenylate kinase-specific inhibitor, and motility was stopped. ATP-supported motility was not affected by Ap5A. Mitochondrial adenylate kinase activity allowed AMP to stimulate respiration in permeabilized sperm. Adenylate kinase activity in tail fragments was most active in a pH range from 7.6 to 8.4, and a similar pH sensitivity was observed for this enzyme activity in a hypotonic extract of whole sperm. The apparent km of adenylate kinase activity in permeabilized tail fragments was about 1.0 mM ADP in the direction of ATP synthesis. The fluctuation of nucleotide concentrations in normal and metabolically stimulated sperm suggested that adenylate kinase was most active when the cell was highly motile, although adenylate kinase activity did not appear to be coupled strictly with motility.
Psychotherapy Outcome Research with Children and Adolescents

After decades of sowing, weeding, harvesting, and winnowing, workers in the field of child and adolescent treatment research have produced a bumper crop. There are now scores of structured interventions for diverse forms of psychological dysfunction across a broad age spectrum. Research-based treatments exist for a substantial range of clinically significant problems and disorders. Although a majority of the more than 230 named therapies for youths have not been tested empirically (see Kazdin, 1988; Kazdin & Weisz, 1996), dozens of such therapies have been subjected to empirical scrutiny, with beneficial effects demonstrated in more than 300 studies. In this chapter, we describe the context of child and adolescent treatment and treatment research, summarize findings of that research, and offer a constructive critique. Finally, we suggest a number of issues that need to be addressed, and approaches that need to be taken, to advance the field. Throughout this chapter, we use the term children to encompass both children and adolescents, except where a distinction needs to be drawn between the two age groups.
The DNA damage-recognition problem in human and other eukaryotic cells: the XPA damage binding protein

The capacity of human and other eukaryotic cells to recognize a disparate variety of damaged sites in DNA, and selectively excise and repair them, resides in a deceptively small simple protein, a 38-42 kDa zinc-finger binding protein, XPA (xeroderma pigmentosum group A), that has no inherent catalytic properties. One key to its damage-recognition ability resides in a DNA-binding domain which combines a zinc finger and a single-strand binding region which may infiltrate small single-stranded regions caused by helix-destabilizing lesions. Another is the augmentation of its binding capacity by interactions with other single-stranded binding proteins and helicases which co-operate in the binding and are unloaded at the binding site to facilitate further unwinding of the DNA and subsequent catalysis. The properties of these reactions suggest there must be considerable conformational changes in XPA and associated proteins to provide a flexible fit to a wide variety of damaged structures in the DNA.
Deciding whether to refer a colleague to a physician health program.

Physicians should exercise caution in referring a possibly impaired colleague to a physician health program (PHP), given that PHPs work closely with their state medical societies or licensing boards but often receive little oversight.
Think Global, Act Local; Projectome Estimation with BlueMatter

Estimating the complete set of white matter fascicles (the projectome) from diffusion data requires evaluating an enormous number of potential pathways; consequently, most algorithms use computationally efficient greedy methods to search for pathways. The limitation of this approach is that critical global parameters - such as data prediction error and white matter volume conservation - are not taken into account. We describe BlueMatter, a parallel algorithm for global projectome evaluation, which uniquely accounts for global prediction error and volume conservation. Leveraging the BlueGene/L supercomputing architecture, BlueMatter explores a massive database of 180 billion candidate fascicles. The candidates are derived from several sources, including atlases and mutliple tractography algorithms. Using BlueMatter we created the highest resolution, volume-conserved projectome of the human brain.
Instrumentation and optimization of Win32/intel executables using Etch

Etch is a general-purpose tool for rewriting arbitrary Win32/x86 binaries without requiring source code. Etch provides a framework for modifying executables for both measurement and optimization. Etch handles the complexities of the Win32 executable file format and the x86 instruction set, allowing tool builders to focus on specifying transformations. Etch also handles the complexities of the Win32 execution environment, allowing tool users to focus on performing experiments. This paper describes Etch and some of the tools that we have built using Etch, including a hierarchical call graph profiler and an instruction layout optimization tool.
Some Waveform and Spectral Features of Vowel Roughness

Acoustic wave-period variation (jitter) and acoustic wave-amplitude variation (shimmer) associated with vowel pronations representing a range of vocal roughness were investigated. Twenty normal-speaking adult males phonated each of the vowels /u/, /i/, /Λ/, /a/, and /ae/, first normally and then with simulated abnormal vocal roughness. Twenty hoarse adult males, each presenting a medically diagnosed laryngeal pathology, also produced each of the five test vowels. To provide a measurable presentation of the frequency and amplitude variations of interest, each recorded vowel was band-pass filtered to isolate the fundamental frequency component. Relations of the jitter and shimmer indices (obtained from the filtered vowel waves) to acoustic spectral noise levels and to roughness ratings for the vowel phonations were studied. The findings supported the hypothesis that increases in vowel acoustic wave variability (estimated by period or amplitude variation or both) are associated with increases in vowel spectra...