cssi/SciSciGPT-SciSciNet huggingface dataset:
The Tale of Tsar Saltan: A Centenary Appreciation of Rimskii-Korsakov's Second Pushkin Opera*

The operas of Nikolai Andreevich Rimskii-Korsakov (1844-1908), along with those of his predecessor Glinka (1804-1857) and his contemporary Chaikovskii (1840-1893), form the foundation of native classic opera repertory in Russia. That all three composers turned to Pushkin as inspiration for one or more of their stage works was inevitable, Rimskii-Korsakov being the last to do so. As with Glinka and Chaikovskii, Rimskii-Korsakov's three Pushkin-based works remain standards in the Russian repertory. Furthermore, his Mozart and Salieri (1897) seems to have good standing in the west, perhaps due to its brevity, non-Russian subject matter, and present-day association with Peter Schaffer's play and motion picture Amadeus . The Golden Cockerel (1906-1907), no doubt helped into western venues by Diagilev's ballet-styled production, has easily become more of a widespread standard than Rimskii-Korsakov's other Pushkin opera, The Tale of Tsar Saltan (1899-1900), which itself nevertheless gained considerable European theatrical exposure in the 1920's and '30's. This apparent repertorial lag is regrettable, because, among all three of these operas, Tsar Saltan has the most to please any audience. To borrow from Mirsky's (1926: 97) evaluation of Pushkin's original poem, Rimskii-Korsakov's opera "has the same appeal for a child of six and for the most sophisticated poetry reader of sixty. It requires no understanding; its reception is immediate, direct, unquestionable." The fact that the creation of the opera Tsar Saltan coincided with the centennial of the poet's birth offers at this time the opportunity to appreciate the interplay of poem and opera as well as their enduring features. This article will examine the opera in view of its background, its adaptation from Pushkin's original verse tale, and its musical treatment by the composer, whose inclinations, abilities, and goals related to this entire congenial enterprise found perhaps the most nearly perfect expression at that particular moment in his creative life.
Warthin's tumor of the parotid gland

Summary Electron microscopical study of two cases of Warthin's tumor, which consists of papillary masses of lymphoid tissue covered by a layer of oncocytes, projecting into cystic spaces.The cytoplasm of the oncocytes are filled with mitochondria of variable sizes and shapes.Squamous cells were found in our two cases.Transitional forms, part squamous and part oncocytic are present.Such cells (showing tonofilments and focal mitochondrial proliferation) as well as lymphocytes showing focal proliferation of mitochondria are reported.
Perceived youth: appraisal and characterization.

Results from a mail survey of respondents aged sixty to ninety-four suggest that psychographic dimensions of youthfulness and identification with old age constitute effective inner-age research variables, especially to those seeking to study older populations. The two specific dimensions explored are: “perceived youth,” a magnitude measure of the proportional discrepancy between chronological and cognitive ages; and “feeling-old,” which inversely measured youth through reliance on a six-point Likert agree/disagree statement: “I feel old.…” In addition to the obvious inverse relationship between these inner-ages, research established trait covariation relative to an increase in perceived youth coincidental with a rejection of a feeling-old identity, corresponding to increases in “happiness, own-health rating, being venturesome, giving advice, self-esteem, social activity, and keeping-in-shape,” as well as decreases in “taking advice, being a homebody, and having health worries.”
Host-Acceptance Behavior of Dinocampus coccinellae (Hymenoptera: Braconidae)

Dinocampus coccinellae (Schrank) spent >80% of a 300-s observation period in host-handling activities (orienting toward, pursuing, and attacking hosts) when exposed to individual adult Coleomegilla maculata (DeGeer) or Coccinella septempunctata (L.). When D. coccinellae was exposed to two populations of Hippodamia variegata (Goeze) from Canada or France and Propylea quatuordecimpunctata (L.) from Canada or Turkey, host-handling activities decreased to <70% of 300 s. D. coccinellae oriented toward and attacked C. maculata and C. septempunctata in 10–12 s, compared with 18–38 s for H. variegata and P. quatuordecimpunctata . Additionally, C. maculata and C. septempunctata were attacked more frequently (mean = 3.3 and 2.6 in 300 s, respectively) than H. variegata or P. quatuordecimpunctata (mean = 2 and 1.5 in 300 s, respectively). No differences in D. coccinellae behavior were observed in response to the two H. variegata and two P. quatuordecimpunctata populations. D. coccinellae successfully emerged from 58% of C. maculata , 47% of C. septempunctata , 7–15% of H. variegata , and 1% of P. quatuordecimpunctata . Total mortality of adults exposed to D. coccinellae was 80% for C. maculata , 76% for C. septempunctata , 50% for H. variegata (France), 38% for H. variegata (Canada), and 11% for both P. quatuordecimpunctata populations. Based upon our observations, we expanded the description of D. coccinellae selection behavior to include orientation, which precedes forward motion toward a host.
Studies of the Energy Requirements of Chickens 4. Evidence for a Linear Relationship Between Dietary Productive Energy Level and the Efficiency of Egg Production

Abstract COMPARATIVE studies of the efficiency of utilization of rations for egg production are made difficult by the well known fact that gross efficiency, measured as feed requirement per dozen eggs produced, is markedly affected by rate of production. Because of this relationship relatively small differences in egg production rate, which may be of limited or no significance in themselves, have the effect of masking or magnifying the respective differences between rations in efficiency of feed utilization. Bird and Whitson (1946) were the first to attempt to circumvent this difficulty by comparing the observed rate of feed consumption to that predicted by the Byerly (1941) partition equation on the basis of the observed rate of production, average body weight and weight gains. From the observed and predicted rates of feed consumption, an index of relative efficiency was calculated for each ration under study. Lillie and coworkers (1952), using a similar procedure, …
In vivo microwave-based thermoacoustic tomography of rats (Conference Presentation)

Microwave-based thermoacoustic tomography (TAT), based on the measurement of ultrasonic waves induced by microwave pulses, can reveal tissue dielectric properties that may be closely related to the physiological and pathological status of the tissues. Using microwaves as the excitation source improved imaging depth because of their deep penetration into biological tissues. We demonstrate, for the first time, in vivo microwave-based thermoacoustic imaging in rats. The transducer is rotated around the rat in a full circle, providing a full two-dimensional view. Instead of a flat ultrasonic transducer, we used a virtual line detector based on a cylindrically focused transducer. A 3 GHz microwave source with 0.6 µs pulse width and an electromagnetically shielded transducer with 2.25 MHz central frequency provided clear cross-sectional images of the rat’s body. The high imaging contrast, based on the tissue’s rate of absorption, and the ultrasonically defined spatial resolution combine to reveal the spine, kidney, muscle, and other deeply seated anatomical features in the rat’s abdominal cavity. This non-invasive and non-ionizing imaging modality achieved an imaging depth beyond 6 cm in the rat’s tissue. Cancer diagnosis based on information about tissue properties from microwave band TAT can potentially be more accurate than has previously been achievable.
Survey of HBV Infection among Employees in Jingyuan County of Ningxia during 2004—2007

[Objective]To understand the HBsAg carrying and status of HBeAg positive among employees of catering and public place in Jingyuan county.[Methods] HBsAg and HBeAg were detected by ELISA.[Results]A total of 3216 employees were examined during 2004—2007. 68 (2.1%) were HBsAg positive,among which 38 were combined with HBeAg positive,occupied 55.88% of HBsAg positive and 1.18% of total number of test. [Conclusion] Preventive health examination and management of health should be strengthened; awareness of health should be improved in employees to raise their self-protection capability. Hepatitis B vaccination should be promoted to raise the level of population immunity.
Gene Therapy in Radiotherapy of Cancer

The primary goal of radiotherapy for cancer patients is to target ionizing irradiation to a tumor volume and avoid the surrounding or adjacent normal tissue. This principal defines the “therapeutic ratio,” which allows dose escalation to acceptable levels for tumor local control (reduction in tumor size and prevention of regrowth). A problem is that normal tissue damage results from radiotherapy beam translation through normal tissues to the target volume. Therefore, successful clinical application of gene therapy in radiotherapy patients has focused on both numerator (tumor cell kill) and denominator (normal tissue damage) components of the therapeutic ratio. Transgene expression in tumor cells can provide radiosensitization and even concomitant tumor cell killing in the case of ionizing irradiation activated transgene transcription. In contrast, radioprotective gene therapy distributes transgene and its product to surrounding normal tissues to minimize radiation damage to the transit volume. Both gene therapy approaches necessitate selective delivery of transgene to critical numbers of cells within each tissue (including tumor) to enhance the therapeutic ratio. Multiple examples of successful application of gene therapy in clinical radiotherapy support further research in this potentially valuable approach toward improving both frequency of uncomplicated cure and improved quality of life for cancer patients.
High Gradient, Large Aperture Quadrupoles for the NSCL Superconducting Spectrometer

The National Superconducting Cyclotron Laboratory (NSCL) is constructing a magnetic spectrometer, the S800, which will consist of two superconducting dipoles and two superconducting quadrupoles. One of the quadrupoles (Q1) has a 24 cm bore and a 34 cm length. The peak gradient of 21 T/m is produced by 2100 turns of 0.7 mm wire operating at 79 A. The maximum stored energy is 64 kJ. The second quadrupole (Q2) has a 42 cm bore and a 30 cm length. Using 0.85 mm wire with 2700 turns operating at 87 A it produces a 6.8 T/m gradient. The stored energy is 146 k.J. A superconducting sextupole is inserted in Q2, which uses 0.3 mm wire and operates at 2 A. All elements are assembled into the same cryostat.
Poling of poly(vinylidene fluoride) at high electric fields

Bernhard Gross and electrets soon become associative terms to anyone entering the fields of electrets. A list of his more than 130 publications can be found in the front of a book resulting from the International Symposium on Electrets and Dielectrics1 held in Sao Carlos, Brazil in honour of his 70th birthday. It contains at least 32 papers related to electrets. I am pleased to contribute to a technical session following Professor Gross's J. B. Whitehead Memorial Lecture.
Biochemistry and Enzymology of Sirtuins

Sirtuins are enzymes that utilize NAD+ as a substrate to effect deacetylation and deacylations of cellular protein substrates. The prototypical reaction characterized for these enzymes is protein lysine N-(epsilon)-deacetylation, which also produces nicotinamide and a novel compound called 2′-O-acetyl-ADPR as co-products. This reaction is catalyzed by an active site that is highly conserved across evolutionary time, and this reaction has been observed for sirtuins encoded by genomes as diverse as mycobacteria, archaea, protozoa as well as humans. The human sirtuin repertoire includes seven isoforms, named SIRT1-7, which have different cellular localizations and cellular functions. These sirtuins have high sequence similarity, particularly in their catalytic domain, but appear to have diversified functions as deacetylases and deacylases. This review broadly considers the catalytic properties of these enzymes and how they are regulated in cells. In particular, emphasis is given to mechanisms that alter sirtuin levels and activities in mammalian cells. Several sirtuin assays are also discussed. This chapter provides a broad overview of the enzymology and biological properties of this enzyme family.
Percutaneous coronary intervention followed by minimally invasive valve surgery compared with median sternotomy coronary artery bypass graft and valve surgery in patients with prior cardiac surgery.

Background: In patients with prior cardiac surgery requiring re-operative coronary and valve surgery, a hybrid approach of percutaneous coronary intervention followed by minimally invasive valve surgery (PCI + MIVS) may be an alternative to the standard median sternotomy coronary artery bypass and valve surgery (CABG + valve). Methods: The outcomes of patients with prior cardiac surgery, presenting with coronary artery and valvular disease, who underwent PCI + MIVS (N=39) were retrospectively compared with those who underwent CABG + valve (N=28) via a repeat median sternotomy, between February 2009 and April 2014. Results: The mean age for the PCI + MIVS versus CABG + valve group was 75±9 and 72±11 years (P=0.54), respectively. The baseline characteristics were similar between groups, with the exception of a greater prevalence of 1-vessel coronary artery disease and clopidogrel or dual antiplatelet therapy at the time of surgery in the PCI + MIVS group, and more 3-vessel coronary artery disease in those undergoing CABG + valve surgery. The PCI + MIVS approach was associated with a decreased aortic cross-clamp (94 vs . 131 minutes, P=0.001) and cardiopulmonary bypass (128 vs . 190 minutes, P vs . 3.8 units, P=0.001), shorter intensive care unit length of stay (41 vs . 71 hours, P vs . 35.7%, P=0.03), re-intubation (2.6% vs . 17.9%, P=0.04), when compared with CABG + valve. The thirty-day and two-year mortality were similar, being 7.7% vs . 7.1% (P=0.66), and 12.8% vs . 10.7% (P=0.55), in the PCI + MIVS vs . CABG + valve group, respectively. Conclusions: Hybrid PCI + MIVS in patients with prior cardiac surgery is associated with shorter operative times and intensive care unit length of stay, less need for intraoperative blood cell transfusions, decreased use of mechanical ventilation, and similar short-term and follow-up survival, when compared with CABG + valve surgery via median sternotomy. Randomized trials and multicenter registries are needed to further evaluate this approach.
Impact of Medicaid disenrollment in Tennessee on breast cancer stage at diagnosis and treatment.

BACKGROUND States routinely may consider rollbacks of Medicaid expansions to address statewide economic conditions. To the authors' knowledge, little is known regarding the effects of public insurance contractions on health outcomes. The current study examined the effects of the 2005 Medicaid disenrollment in Tennessee on breast cancer stage at the time of diagnosis and delays in treatment among nonelderly women. METHODS The authors used Tennessee Cancer Registry data from 2002 through 2008 and estimated a difference-in-difference model comparing women diagnosed with breast cancer who lived in low-income zip codes (and therefore were more likely to be subject to disenrollment) with a similar group of women who lived in high-income zip codes before and after the 2005 Medicaid disenrollment. The study outcomes were changes in stage of disease at the time of diagnosis and delays in treatment of >60 days and >90 days. RESULTS Overall, nonelderly women in Tennessee were diagnosed at later stages of disease and experienced more delays in treatment in the period after disenrollment. Disenrollment was found to be associated with a 3.3-percentage point increase in late stage of disease at the time of diagnosis (P = .024), a 1.9-percentage point decrease in having a delay of >60 days in surgery (P = .024), and a 1.4-percentage point decrease in having a delay of >90 days in treatment (P = .054) for women living in low-income zip codes compared with women residing in high-income zip codes. CONCLUSIONS The results of the current study indicate that Medicaid disenrollment is associated with a later stage of disease at the time of breast cancer diagnosis, thereby providing evidence of the potential negative health impacts of Medicaid contractions. Cancer 2017;123:3312-9. © 2017 American Cancer Society.
Error Performance in a Simultaneous Discrimination Employing Fixed-Ratio Reinforcement

6 children and 2 adults performed a 3-stimulus, simultaneous discrimination for fixed-ratio reinforcement. More responses to an S− (i.e., errors) were located in the first halves than in the second halves of the fixed ratios studied. One kind of error occurred most frequently and was associated with cases where the majority of errors was located in the first half of a ratio. A second type of error was associated with cases where the majority of errors was found in the second half of the ratio. This finding suggests that error patterns on discrimination tasks are some joint function of response strategies and the reinforcement schedule.
A NEW SPECIES OF PENTAGONIA (RUBIACEAE: HIPPOTIDEAE) FROM SOUTHERN PERU

Recent floristic exploration in the Madre de Dios River basin and its tributary the Los Amigos River in southern Peru has continued the discovery of Rubiaceae species new to science, including the new species described here. Pentagonia australis C.M. Taylor & Janovec (Hippotideae) is distinguished by the combination of its subsessile leaves that are truncate to rounded at the base, its well developed and regularly lobed calyx limbs, and its tubular yellow corollas with short lobes. Also corolla form and size are detailed for the first time for two similar species found in Peru, R microcarpa L. Andersson & Rova and P. pachiteana Cornejo.
Challenges in Making Broad Healthy Lifestyle Plans: Revisiting the Nature of Health Interventions

Publisher Summary To reverse the current trends of obesity and diet-related diseases, the implementation of the policy framework provided by the Diet, Physical Activity and Health must be urgently accelerated. In order to be effective, this implementation must not only be rapid and comprehensive, but also be combined with the development of international standards and regulations in selected areas. In low- and middle-income countries facing a double burden of diseases, this implementation must be a component of an intersectoral, multi-level response to address premature mortality and ill-health due to non-communicable diseases and their risk factors. To improve national situations, it is imperative to support the operationalization of non-communicable disease strategies and action plans where they are already in place, develop strategies and action plans where they are absent, and coordinate existing and ongoing activities, while concentrating on strategic priorities in order to bridge existing gaps and provide an effective monitoring and evaluation mechanism. Combating obesity and, more generally, non-communicable diseases and their risk factors calls for abandoning a narrow understanding of what public health policy is about. No healthy lifestyle plan will be successful without recognizing that improvements are no longer achievable without tackling the social determinants of health.
Archimedes the Military Engineer

Archimedes was not the first engineer to apply the principles of defense-in-depth to a military campaign, but his unique and systematic approach to the problem caught the attention of his contemporaries as well as that of future generations. Indeed, David Lane, historian of operations research, cites Archimedes’ defense of Syracuse as a precursor to the systems approach to military operations, 23 centuries before the term was even invented.
Mapping hidden aircraft defects with dual-band infrared computed tomography

Infrared computed tomography (IRCT) is a promising, non-contact, nondestructive evaluation tool used to inspect the mechanical integrity of large structures. We describe on-site, proof-of-principle demonstrations of IRCt to inspect defective metallic and composite structures. The IRCT system captures time sequences of heat-stimulated, dual-band infrared (DBIR) thermal maps for flash-heated and naturally-heated targets. Our VIEW algorithms produce co-registered thermal, thermal inertia, and thermal-timegram maps from which we quantify the percent metal-loss corrosion damage for airframes and the defect sites, depths, and host-material physical properties for composite structures. The IRCT method clarifies the type of defect, e.g., corrosion, fabrication, foreign-material insert, delamination, unbond, void, and quantifies the amount of damage from the defect, e.g., the percent metal-loss from corrosion in metal structures, the depth, thickness, and areal extent of heat damage in multi-layered composite materials. Potential long-term benefits of IRCT technology are in-service monitoring of incipient corrosion damage, to avoid catastrophic failure and production-monitoring of cure states for composite materials.
Destruction of Gypsy Moth Egg Masses (Using Surfactants, Detergents, Oils or Conventional Insecticides) for Quarantine and Community Action Programs

A series of studies were conducted, beginning in 1976, at the Otis Methods Development Center, Otis ANGB, MA, and beginning in 1982 at the Beltsville Agricultural Research Center, Beltsville, MD, t...
Identification of swallowing disorders in early and mid-stage Parkinson's disease using pattern recognition of pharyngeal high-resolution manometry data.

Background Parkinson's disease (PD) can cause severe dysphagia, especially later in disease progression. Early identification of swallowing dysfunction may lead to earlier intervention. Pharyngeal high-resolution manometry (HRM) provides complementary information to videofluoroscopy, with advantages of being quantitative and objective. Artificial neural network (ANN) classification can examine non-linear relationships among multiple variables with relatively low bias. We evaluated if ANN techniques could differentiate between patients with PD and healthy controls. Methods Simultaneous videofluoroscopy and pharyngeal HRM were performed on 31 patients with early to mid-stage PD and 31 age- and sex-matched controls during thin-liquid swallows of 2 cc, 10 cc and comfortable sip volume. We performed multilayer-perceptron analyses on only videofluoroscopic data, only HRM data or a combination of the two. We also evaluated variability-based parameters, representing variability in manometric parameters across multiple swallows. We hypothesized that patients with PD and controls would be classified with at least 80% accuracy, and that combined videofluoroscopic and HRM data would classify participants better than either alone. Key Results Classification rates were highest with all parameters considered. Maximum classification rate was 82.3 ± 5.2%, recorded for 2 cc swallows. Inclusion of variability-based parameters improved classification rates. Classification rates using only manometric parameters were similar to those using all parameters, and rates were substantially lower for the comfortable sip volumes. Conclusions & Inferences Results from these classifications highlight the differences between swallowing function in patients with early and mid-stage PD and healthy controls. Early identification of swallowing dysfunction is key to developing preventative swallowing treatments for those with PD.
From “the gates of Eden” to “day of the locust”

The cohesion of the white middle class youth movement of the 1960s was based upon a shared subculture of dissidence. So long as this subculture was evolving in the direction of a more intense, more widespread revolt, with broader aims, each successive cultural phase had been spearheaded by an indicative minority which acted out the most profound impulse of revolt within the youth culture as a whole and provided a style to be emulated by those less fully committed. Smaller vanguard nuclei, basically primary groups, crystallized the idealized collective self-image of the indicative minorities into mythical models.
SECONDARY BATTERIES – LITHIUM RECHARGEABLE SYSTEMS | Lithium–Iron Sulfide

The rechargeable lithium–iron sulfide battery was the first lithium battery to be developed for use in an electric vehicle. This high-temperature molten-salt battery dominated the lithium battery field for nearly two decades, until the advent of the high-voltage lithium ion battery. Its many advantages such as high specific power and energy (500 Wh kg−1 theoretical) combined with the abundance of iron sulfide minerals created attention nationwide. Cells based on the lithium alloy–iron sulfide couple operate for hundreds of cycles with energy densities of 120–160 Wh kg−1 and area-specific impedances of 0.6 Ω cm2. The problems of operating at temperatures close to 450 °C with a molten electrolyte, which was difficult to contain, prevented this battery from reaching complete commercialization. Lithium–pyrite cells operating in modern lithium-ion and lithium-polymer electrolytes (20–135 °C) have yet to demonstrate good capacity retention and cycle life. The overwhelming cost advantages of using pyrite in a rechargeable battery guarantees that the final article in this technology has someday to be written.
Oncogenes in Renal Cell Carcinoma

The study of oncogenes in human tumors has yielded significant insights into the molecular basis for the origin, development, and progression of many cancers and sometimes provided clinically useful information. These were initially cytogenetic characterization and detailed mapping studies which identified the location of oncogenes near chromosomal breakpoints. With advances in molecular technology and applying lessons learned from the study of hematologic tumors, the study of oncogenes in human solid tumors has advanced significantly in the past several years. At present, information regarding which oncogenes are important in renal cell carcinoma (RCC) and detailed study of their structure, expression, modes of action, and biologic significance are limited. This chapter will review the published data on oncogenes in renal cancers and attempt to integrate the findings into models of known oncogene function. Areas in which information is lacking will be highlighted and directions for future studies suggested.
Nutrition Messages in Picture Book Fiction for 4 to 8 Year Old Children

This study conducted a content analysis to examine the types of food and nutrition messages communicated in fictional stories aimed at children 4 to 8 years of age. The foundation of healthy eating...
Desense Prediction and Mitigation from DDR Noise Source

Ahstract- In this paper, the dipole-moment based reciprocity method is used to perform desense prediction and mitigation from the DDR noise source to the nearby RF antenna. The noise source is from the DDR signals between the application processor and the memory IC. Radiation physics of the noise source is analyzed by understanding of the current flow. Firstly, the random nature of the DDR signals is analyzed using the measurement data. Based on the measurement data, the setup of the near field scanning is further determined. The desense prediction procedures are decomposed into two steps: the forward problem and the reverse problem. In the forward problem, the noise source is approximately regarded as a single magnetic dipole moment based on the near field scanning above this specific electronic device. In the reverse problem, the transfer function from the magnetic dipole moment to the victim antenna is obtained by measuring the H field when the victim antenna radiates. Based on the measurements of forward and reverse problem, the coupled noise to the victim antenna can be analytically estimated. The estimated RFI results are compared with direct RFI measurement to validate the dipole-moment based reciprocity method. Lastly, a few methods to mitigate the desense are also discussed.
QM-Mechanism-Based Hierarchical High-Throughput in Silico Screening Catalyst Design for Ammonia Synthesis.

We propose and test a hierarchical high-throughput screening (HHTS) approach to catalyst design for complex catalytic reaction systems that is based on quantum mechanics (QM) derived full reaction networks with QM rate constants but simplified to examine only the reaction steps likely to be rate determining. We illustrate this approach by applying it to determine the optimum dopants (our of 35 candidates) to improve the turnover frequency (TOF) for the Fe-based Haber–Bosch ammonia synthesis process. We start from the QM-based free-energy reaction network for this reaction over Fe(111), which contains the 26 most important surface configurations and 17 transition states at operating conditions of temperature and pressure, from which we select the key reaction steps that might become rate determining for the alloy. These are arranged hierarchically by decreasing free-energy reaction barriers. We then extract from the full reaction network, a reduced set of reaction rates required to quickly predict the effect of the catalyst changes on each barrier. This allows us to test new candidates with only 1% of the effort for a full calculation. Thus, we were able to quickly screen 34 candidate dopants to select a small subset (Rh, Pt, Pd, Cu) that satisfy all criteria, including stability. Then from these four candidates expected to increase the TOF for NH3 production, we selected the best candidate (Rh) for a more complete free-energy and kinetic analysis (10 times the effort for HHTS but still 10% of the effort for a complete analysis of the full reaction network). We predict that Rh doping of Fe will increase the TOF for NH_3 synthesis by a factor of ∼3.3 times compared to Fe(111), in excellent agreement with our HHTS predictions, validating this approach.
On the Application of MIMO Space-Time Coding to Physical Layer Security in sub-6 GHz 5G

This paper investigates the application and performance improvement of MIMO Space Time Block Coding (STBC) for Physical Layer Security. The paper analyzes a Precoder Matrix Index (PMI) based scheme called Private Random Precoding (PRP). Key-based Physical Layer Security protects against eavesdroppers in wireless communication links, invaluable in emerging 5G and IoT networks. This paper derives improvements in PRP based on STBC. Also presented are simulation results which show as much as 7 dB improvement in Key bit Error Rate performance vs SINR of the enhanced PRP-STBC scheme for a 1-bit codebook at the cost of decreased transmission rate. In addition, the paper derives a closed form expression for the Key bit Error Rate for both the PRP and enhanced PRP-STBC schemes as a function of dense 5G cellular geometries. Furthermore, we present the effective information rate of the PRP key based communication framework in low SNR scenarios.
Pedagogy and Practice: Teaching an Interdisciplinary Art History and Disability Studies Course

The necessity for curriculum reform within the fields of art history, visual arts, and art education cannot be overstated. The article seeks to further a discussion of critical pedagogical strategi...
Exploring the space of jets with CMS open data

We explore the metric space of jets using public collider data from the CMS experiment. Starting from $2.3\text{ }\text{ }{\mathrm{fb}}^{\ensuremath{-}1}$ of proton-proton collisions at $\sqrt{s}=7\text{ }\text{ }\mathrm{TeV}$ collected at the Large Hadron Collider in 2011, we isolate a sample of 1,690,984 central jets with transverse momentum above 375 GeV. To validate the performance of the CMS detector in reconstructing the energy flow of jets, we compare the CMS Open Data to corresponding simulated data samples for a variety of jet kinematic and substructure observables. Even without detector unfolding, we find very good agreement for track-based observables after using charged hadron subtraction to mitigate the impact of pileup. We perform a range of novel analyses, using the ``energy mover's distance'' (EMD) to measure the pairwise difference between jet energy flows. The EMD allows us to quantify the impact of detector effects, visualize the metric space of jets, extract correlation dimensions, and identify the most and least typical jet configurations. To facilitate future jet studies with CMS Open Data, we make our datasets and analysis code available, amounting to around two gigabytes of distilled data and one hundred gigabytes of simulation files.
Testing the obesity paradox in patients on long-term milrinone infusion for end-stage heart failure.

BACKGROUND Obese patients with chronic HF have a lower mortality than do non-obese patients with heart failure (HF) i.e. "obesity paradox". We sought to determine the relationship between obesity (defined by body-mass index; BMI) and survival in inotrope-dependent patients with Stage D HF. METHODS AND RESULTS We screened the medical records of adults with ACC/AHA stage D HF who were admitted to our institution between January, 2010 and July, 2018 who were both initiated and discharged on continuous intravenous milrinone. Patients were divided into three groups: non-obese patients (Nob-BMI < 30 kg/m2), Class 1 obese patients (Ob1-BMI 30 to 34.9 kg/m2), and class 2/3 obese patients (Ob2/3-BMI ≥ 35 kg/m2). The primary endpoint was all-cause mortality. Of the 233 patients included in the study, 154 were NOb, 39 were Ob1, and 40 were OB2/3. Age and baseline comorbidities did not differ significantly among the groups. Mean follow up was 21.8 months (Median: 12.4, IQ range: 3.6-31.3). Compared to the NOb, relative mortality (HR) was 0.68 for Ob1 patients and 1.21 for Ob2/3 patients (P = 0.30). Adjusting for age, sex, race, and medical comorbidities, relative mortality was 0.85 in the Ob1 and 1.77 in the Ob2/3 (P = 0.08). CONCLUSION In this retrospective study of stage D inotrope-dependent HF patients, there was trend of an "obesity paradox" with higher survival in the Ob1 group patients compared to NOb and Ob2/3 patients. Ob2/3 patients had the worst survival.
Acral localized acquired cutis laxa as presenting sign of underlying systemic amyloidosis.

Acral localized acquired cutis laxa (ALACL) is a rare variant of acquired cutis laxa, and the clinical appearance is characterized by loose, redundant and wrinkled skin of the distal extremities. By definition, histology of affected tissue reveals sparse or fragmented elastic fibers. However, this can be difficult to assess on routine staining, and sometimes requires electron microscopy. The condition has been associated with plasma cell dyscrasias or recurrent inflammatory states. We present a case of a 65-year-old man who presented with enlarged and doughy finger pads. Skin biopsy showed diffuse dermal amyloid deposition displacing dermal stroma and reduction of elastic fibers, though these changes were subtle on routine hematoxylin and eosin staining. Mass spectrometry of laser capture microdissected tissue showed AL kappa-type amyloid and further workup revealed a diagnosis of primary systemic AL-kappa amyloidosis requiring bone marrow transplantation. This case represents an unusual presentation of acquired cutis laxa and highlights the need for a high index of suspicion when reviewing histopathology of this entity. In addition, the case highlights the importance of investigation into possible systemic associations, such as plasma cell dyscrasias. This article is protected by copyright. All rights reserved.
Juvenile idiopathic arthritis is associated with higher healthcare utilization after total knee or hip replacement.

To assess whether juvenile idiopathic arthritis (JIA) is associated with healthcare utilization and in-hospital complications after total hip or knee arthroplasty (THA/TKA). We used the 1998–2014 U...
Genotypic variation of flavonols and antioxidant capacity in broccoli

Flavonols are gaining increasing interests due to their diverse health benefits for humans. Broccoli is a main flavonol source in our diet, but the genetic variation of flavonols and their correlation with antioxidant capacity remain to be understood. Here, we examined variations of the two major flavonols kaempferol and quercetin in florets and leaves of 15 diverse broccoli accessions by ultra-performance liquid chromatography. Broccoli accumulated more kaempferol than quercetin in most of the accessions tested, with the ratios varying from 4.4 to 27.9 in leaves and 0.4 to 4.4 in florets. Total flavonoids showed 2.5-fold and 3.3-fold differences in leaves and florets of these accessions, respectively. Principle component analysis revealed that flavonols, along with the key biosynthetic pathway genes, correlated with antioxidant capacity related indicators. This study provides important information for broccoli flavonol genotypic variations and correlation with antioxidant capacity, and will facilitate the development of flavonol enriched cultivars in broccoli.
Computational science and re-discovery: open-source implementation of ellipsoidal harmonics for problems in potential theory

We present two open-source (BSD) implementations of ellipsoidal harmonic expansions for solving problems of potential theory using separation of variables. Ellipsoidal harmonics are used surprisingly infrequently, considering their substantial value for problems ranging in scale from molecules to the entire solar system. In this paper, we suggest two possible reasons for the paucity relative to spherical harmonics. The first is essentially historical?ellipsoidal harmonics developed during the late 19th century and early 20th, when it was found that only the lowest-order harmonics are expressible in closed form. Each higher-order term requires the solution of an eigenvalue problem, and tedious manual computation seems to have discouraged applications and theoretical studies. The second explanation is practical: even with modern computers and accurate eigenvalue algorithms, expansions in ellipsoidal harmonics are significantly more challenging to compute than those in Cartesian or spherical coordinates. The present implementations reduce the 'barrier to entry' by providing an easy and free way for the community to begin using ellipsoidal harmonics in actual research. We demonstrate our implementation using the specific and physiologically crucial problem of how charged proteins interact with their environment, and ask: what other analytical tools await re-discovery in an era of inexpensive computation?
Cognitive Behavioral Therapy: The Case of Wally

This chapter provides a brief historical and practical overview of cognitive behavioral therapy (CBT). Key components of the theoretical model, such as problem maintenance and change mechanisms, are discussed. Specific treatment methods and interventions described include cognitive restructuring, the downward arrow technique, skill building, thought records, and behavioral experiments. The model is then applied to the case of Wally, a 62-year-old African American male, who has recently retired from his career and lost his wife of 40 years. Finally, cultural considerations are discussed to provide guidance on how to apply CBT with this client in the context of the client’s race, age, and sociohistorical background.
Cost of Arthroscopic Rotator Cuff Repairs Is Primarily Driven by Procedure-Level Factors: A Single-Institution Analysis of an Ambulatory Surgery Center.

Purpose To identify intraoperative drivers of cost associated with arthroscopic rotator cuff repairs (RCRs) through analysis of an institutional database. Methods This was a single-institution retrospective review of arthroscopic RCRs performed at an ambulatory surgical center between November 2016 and July 2019. Patient-level factors analyzed included age, sex, insurance type (private, Medicare, Medicaid, self-pay, and other government), American Society of Anesthesiologists grade (I, II, III, and missing), and Charlson comorbidity index (0, 1, 2, and ≥3). Procedure-level factors included use of biologics (decellularized dermal allograft or bioinductive healing implant), anesthesia type (regional block, monitored anesthesia care, or general), number of anchors and sutures, additional procedures (biceps tenodesis, distal clavicle resection, subacromial decompression), and operative time. Multivariate linear regression analysis was used to identify factors significantly associated with higher or lower charges. Results A total of 712 arthroscopic RCRs were included. The risk-adjusted operative charges were $19,728 (95% confidence interval $16,543 to $22,913). The above factors predicted nearly 65% of the variability in operative charges. The only patient-level factor significantly associated with lower charges was female sex (– $1,339; P = .002). Procedure-level factors significantly associated with higher charges were use of biologics (+ $17,791; P Conclusions Procedural factors are the most significant drivers of operative cost in arthroscopic RCRs, such as quantity and type of implants; additional procedures such as biceps tenodesis and distal clavicle resection; and perioperative conditions such as type of anesthesia and total operating room time. Overall, patient-level factors were not shown to correlate well with operative costs, other than lower charges with female sex. Level of Evidence IV, economic study.
Publishing Papers by Students and Identifying their Authors

Although I have not done justice to Hennie’s paper, I’ll say no more about it, except that I have become convinced that it should be made available whole, with Hennie’s authorization, of course.
Poor Weight Recovery Between Stage 1 Palliation and Hospital Discharge for Infants with Single Ventricle Physiology: An Analysis of the National Pediatric Cardiology Quality Improvement Collaborative Phase II Dataset.

Objective To investigate change in weight-for-age z-scores (WAZ) and risk factors for impaired weight gain between stage 1 palliation (S1P) for single ventricle physiology and discharge. Study design This was a secondary analysis of the National Pediatric Cardiology Quality Improvement Collaborative Phase II database. The primary outcome was change in WAZ between S1P and discharge. Risk factors were selected using multivariable mixed effects regression constructed by step-wise model selection, with adjustment for WAZ at S1P and a random effect for center. Results Of 730 infants who were discharged after S1P, WAZ decreased in 98.6% (−1.5 ± 0.7). WAZ at discharge was −2 (at risk) in 40% and Conclusions Nearly all infants lose weight after S1P with little recovery by hospital discharge. At discharge, three-quarters of the infants in the cohort were at risk for impaired weight gain or had failure to thrive. Most risk factors associated with change in WAZ were unmodifiable or surrogates of disease severity. Novel interventions are needed to minimize the early catabolic effects and promote anabolic recovery after S1P.
New model integrates innate responses, PML-NB formation, epigenetic control and reactivation from latency

The dynamic nature of interactions between invading viral pathogens and their hosts has fascinated scientists for several decades. The well-known capacity of herpes simplex virus (HSV) to establish life-long infections in humans reflects a dynamic balance between maintaining a latent state in which viral genomes are silenced and re-entry into the lytic phase during reactivation. Silencing of the viral genome has been shown to be a function of innate immune signalling, intrinsic cellular antiviral mechanisms and epigenetic repression. Thus, although many important observations have been made identifying cellular processes that contribute to the repression of the viral genome and latency, the field has lacked an understanding of how these factors work together. In this issue of EMBO Reports, Suzich et al (2021) present convincing evidence that brings together individual observations into a cohesive model that explains many of these outstanding mysteries. Here, we will review the background data that lead to this outstanding piece of work.
Psychological Interventions for the Treatment of Chronic Pain in Adults.

The high prevalence and societal burden of chronic pain, its undertreatment, and disparities in its management have contributed to the acknowledgment of chronic pain as a serious public-health conc...
Evaluating the effect of conjugation on the bioactivities of whey protein hydrolysates

In this study, the ability of a whey protein hydrolysate to exhibit the antimicrobial, antioxidant, and antihypertensive behavior after combining with a reducing carbohydrate was studied. Whey protein hydrolysates with varying degrees of hydrolysis (WPH10, WPH15, and WPH20) were determined for their antimicrobial, antioxidant, and antihypertensive activities. Of these, hydrolysate (WPH10) exhibited the highest antimicrobial activity (with 10-11.2 mm zone of inhibition) against tested microorganisms: Listeria innocua, Staphylococcus aureus, and Bacillus coagulans. Also, the WPH10 exhibited the highest antioxidant (866.56 TEAC µmol/L) and antihypertensive (67.52%) attributes. Hence, based on the highest bioactivity, hydrolysate WPH10 was selected for conjugation with maltodextrin, and the effect of conjugation on the bioactivities was evaluated. The conjugated WPH10 solution demonstrated higher antimicrobial (17.16 mm) and antioxidant activity (1044.37 TEAC µmol/L), whereas a slight decrease in the antihypertensive activity (65.4%) was observed, as compared to WPH10 alone. The conjugated solution was further spray dried and alternatively, freeze-dried. The dried WPH10 conjugate exhibited even higher antimicrobial (18.5 mm) and antioxidant activity (1268.89 TEAC µmol/L) while retaining the antihypertensive activity (65.6%). Overall, the results indicate the ability of the WPH10-maltodextrin to retain the bioactive behavior after combining with a reduced carbohydrate. PRACTICAL APPLICATION: Whey protein hydrolysates upon conjugation with carbohydrates retain the bioactive properties of whey protein, which provides opportunities for application as an ingredient to develop novel health formulations.
Fully integrated ballast controller with digital phase control

An integrated ballast controller fabricated in a 0.8 mum CMOS process is presented that includes digital phase control, current regulation and soft-start ignition. The primarily digital approach provides programmability for broad application, insensitivity to process and temperature variations, and few external components. Experimental results are provided for a 400 W HID electronic ballast
A machine learning strategy for predicting march madness winners

The Division I NCAA Men's Basketball Tournament is a popular sporting event held annually to determine the leagues National Champion. Over the past several years the betting scene surrounding the tournament has become arguably more popular than the tournament itself, drawing in fans who bet billions overall on its outcome. In this paper, we discuss the statistical challenges in correctly predicting winners in the tournament and present a machine learning strategy for predicting the games. The Kaggle Machine Learning March Mania Competition was used to test the effectiveness of the model by comparing it against other machine-learning-based models submitted to the competition. Overall, the project was considered successful as it scored in the top 15 percentile of all submissions.