cssi/SciSciGPT-SciSciNet huggingface dataset:
Current enhancement in regioregular poly(thiophene) thin film transistors

Thin-film transistors (TFTs) made with solution-processed polymeric semiconductors are being developed for use in large-area, low-cost electronic devices such as displays. The carrier mobility in most polymers is about ten times smaller than that in amorphous silicon. To be useful for circuits, the dimensions of TFTs made with polymers must be scaled to compensate for this deficiency because high-quality, ultra-thin or high-k dielectrics are not available for these applications. Deviations from ideal FET behavior are widely reported for polymer TFTs with channel lengths shorter than /spl sim/10 /spl mu/m and these deviations are currently not understood. In this paper, we present an explanation of this phenomenon for the first time. 2D simulations will be necessary to further model the current-voltage characteristics. These data are important for the development of device models for polymeric circuits and for the determination of materials properties from I-V characteristics of TFTs.
Indirect Measurements Via Polynomial Chaos Observer

This paper proposes an innovative approach to the design of algorithms for indirect measurements based on a polynomial chaos observer (PCO). A PCO allows the introduction and management of uncertainty in the process. The structure of this algorithm is based on the standard closed-loop structure of an observer originally introduced by Luenberger. This structure is here extended to include uncertainty in the measurement and in the model parameters in a formal way. Possible applications of this structure are then also discussed
Interaction of the 3′-end of tRNA with ribonuclease P RNA

Ribonuclease P, which contains a catalytic RNA subunit, cleaves 5' precursor-specific sequences from pre-tRNAs. It was previously shown that the RNase P RNA optimally cleaves substrates which contain the mature, 3'-terminal CCA of tRNA. In order to determine the contributions of those individual 3'-terminal nucleotides to the interaction, pre-tRNAs that have CCA, only CC or C or are without CCA at the 3'-end were synthesized by run-off transcription, tested as substrates for cleavage by RNase P RNA and used in photoaffinity crosslinking experiments to examine contact sites in the ribozyme. In order to generalize the results, analyses were carried out using three different bacterial RNase P RNAs, from Escherichia coli, Bacillus subtilis and Thermotoga maritima. At optimal (Kcat/Km) ionic strength (1 M NH4+/25 mM Mg2+), Km increases incrementally 3- to 10-fold upon stepwise removal of each nucleotide from the 3'-end. At high ionic strength (2 M NH4+/50 mM Mg2+), which suppresses conformational effects, removal of the 3'-terminal A had little effect on Km, indicating that it is not a specific contact. Analysis of the deletion and substitution mutants indicated that the C residues act specially; their contribution to binding energy at high ionic strength (approximately 1 kcal/mol) is consistent with a non-Watson-Crick interaction, possibly irregular triple-strand formation with some component of the RNase P RNA. In agreement with previous studies, we find that the RNase P holoenzyme in vitro does not discriminate between tRNAs containing or lacking CCA. The structural elements of the three RNase P RNAs in proximity to the 3'-end of tRNA were examined by photoaffinity crosslinking. Photoagent-labeled tRNAs with 3'-terminal CCA, only CC or C, or lacking all these nucleotides were covalently conjugated to the three RNase P RNAs by irradiation and the sites of crosslinks were mapped by primer extension. The main crosslink sites are located in a highly conserved loop (probably an irregular helix) that is part of the core of the RNase P RNA secondary structure. The crosslinking results orient the CCA of tRNA with respect to that region of the RNase P RNA.
Neck dissection after twice-a-day radiotherapy: morbidity and recurrence rates.

Between March 1978 and April 1986, 56 patients underwent planned unilateral, and five patients underwent planned bilateral, radical neck dissections following high-dose twice-a-day radiotherapy, usually with 60Co. Neck dissections were generally performed 6 weeks after radiotherapy. The overall rate of control of disease in the neck in all 61 patients was 81% at 5 years. Patients who underwent neck dissections following radiotherapy had significantly higher rates of heck-disease control than patients treated by radiotherapy alone during the same time period for stages N2A-N3A and N2B-N3B, but not for N1 disease. No carotid ruptures or fatal complications occurred. The rate of wound complications was judged to be acceptable.
Competition Between Two MHC Binding Registers in a Single Peptide Processed from Myelin Basic Protein Influences Tolerance and Susceptibility to Autoimmunity

Experimental allergic encephalomyelitis (EAE) is an animal model for multiple sclerosis induced by stimulating myelin basic protein (MBP)-specific T cells. The MBP-specific repertoire in B10.PL mice is shaped by tolerance mechanisms that eliminate MBP121–150–specific T cells. In contrast, MBPAc1–11–specific T cells escape tolerance and constitute the encephalitogenic repertoire. To determine if this differential tolerance is caused by differences in the abundance of MBP epitopes generated by processing, MBP peptides were eluted from I-Au complexes and analyzed by mass spectrometry. Peptides were identified from both the NH2-terminal and MBP121–150 regions. Unexpectedly, MBPAc1–18 and Ac1–17, which contain the MBPAc1–11 epitope, were much more abundant than MBP121–150 peptides. The results demonstrate that competition between two I-Au binding registers, a low affinity register defined by MBPAc1–11 and a high affinity register defined by MBP5–16, prevents most of the NH2-terminal naturally processed peptides from binding in the MBPAc1–11 register. The small fraction of MBPAc1–18 bound in the MBPAc1–11 register is not sufficient to induce tolerance but provides a ligand for MBPAc1–11–specific T cells during disease. These results provide a basis for both the lack of tolerance to MBPAc1–11 and the ability of this epitope to become a target during autoimmunity.
Biosynthesis of sex pheromone components from linolenic acid in arctiid moths

Sex pheromone components of two species of arctiid moths, Estigmene acrea and Phragmatobia fuliginosa, were shown to be derived from linolenic acid. Female pupae were injected with radiolabeled malonic acid or an 18-, 20-, 21-, or 22-carbon triunsaturated fatty acid, and the pheromone components from emerged adults analyzed for radioactivity. The data support a biosynthetic pathway in which the 21-carbon pheromone component,(Z, Z)-3,6-cis-9,10-epoxyheneicosadiene, of these moths is produced by chain elongation of linolenic acid to docosatrienoic acid with subsequent reductive decarboxylation. The 18-carbon aldehyde components,(Z, Z)-9,12-octadecadienal and (Z, Z, Z)-9,12,15-octadecatrienal, of E. acrea are produced from linoeic and linolenic acids directly. No detectable amounts of intermediate 20-, 21-, or 22-carbon fatty acid precursors were found in the gland of E. acrea.
Singular value decompositions and digital image processing

The use of singular value decomposition (SVD) techniques in digital image processing is of considerable interest for those facilities with large computing power and stringent imaging requirements. The SVD methods are useful for image as well as quite general point spread function (impulse response) representations. The methods represent simple extensions of the theory of linear filtering. Image enhancement examples will be developed illustrating these principles. The most interesting cases of image restoration are those which involve space variant imaging systems. The SVD, combined with pseudoinverse techniques, provides insight into these types of restorations. Illustrations of large scale N2× N2point spread function matrix representations are discussed along with separable space variant N2× N2point spread function matrix examples. Finally, analysis and methods for obtaining a pseudoinverse of separable space variant point spread functions (SVPSF's) are presented with a variety of object and imaging system dagradations.
TGFβ-like Signaling and Spicule Development in Caenorhabditis elegans

A TGFbeta-like signal is required for spicule development in Caenorhabditis elegans males. This signal appears to originate in the male-specific musculature and is required for the migrations of cells within the proctodeum. The migrations of these cells form cellular molds, the spicule traces, in which the cuticle of the spicules is secreted. Mutations in daf-4, sma-2, sma-3, and sma-4, which disrupt TGFbeta-like signaling, result in aberrant migrations and morphologically abnormal spicules. daf-4, and hence the TGFbeta-like signal, is required prior to or during cell migrations. Therefore, the TGFbeta-like signal may act to prime the migrating cells or as a guidance cue. Mutations in lin-31 result in identical cell migration and spicule morphology defects. Thus, lin-31, which encodes a "winged helix" protein (Miller et al., Genes Dev. 7, 933-947, 1993), may be a component of this TGFbeta-like signaling pathway.
Activated α2-Macroglobulin Regulates Transcriptional Activation of c-MYC Target Genes through Cell Surface GRP78 Protein *

Activated α2-macroglobulin (α2M*) signals predominantly through cell surface GRP78 (CS-GRP78) to promote proliferation and survival of cancer cells; however, the molecular mechanism remains obscure. c-MYC is an essential transcriptional regulator that controls cell proliferation. We hypothesize that α2M*/CS-GRP78-evoked key signaling events are required for transcriptional activation of c-MYC target genes. Activation of CS-GRP78 by α2M* requires ligation of the GRP78 primary amino acid sequence (Leu(98)-Leu(115)). After stimulation with α2M*, CS-GRP78 signaling activates 3-phosphoinositide-dependent protein kinase-1 (PDK1) to induce phosphorylation of PLK1, which in turn induces c-MYC transcription. We demonstrate that PLK1 binds directly to c-MYC and promotes its transcriptional activity by phosphorylating Ser(62) Moreover, activated c-MYC is recruited to the E-boxes of target genes FOSL1 and ID2 by phosphorylating histone H3 at Ser(10) In addition, targeting the carboxyl-terminal domain of CS-GRP78 with a mAb suppresses transcriptional activation of c-MYC target genes and impairs cell proliferation. This work demonstrates that α2M*/CS-GRP78 acts as an upstream regulator of the PDK1/PLK1 signaling axis to modulate c-MYC transcription and its target genes, suggesting a therapeutic strategy for targeting c-MYC-associated malignant progression.
Pharmacologic management of migraine--1985.

There are many pharmacologic agents available for treating patients with migraine. One must first decide whether daily prophylactic medication or intermittent acute abortive therapy is indicated. New agents are available for both prophylactic and abortive treatments. Metoclopramide, an antinauseant, has proved to be a useful adjunct in managing acute migrainous attacks. Beta blockers and the new calcium channel antagonists can control the number and severity of attacks in many patients. The anti-inflammatory agents are being used extensively for both migraine and chronic muscle contraction headache. This review focuses on the pharmacologic actions and optimum use of medications in the migraine patient.
No need to know

I introduce and defend an argument against the popular view that anything falling short of knowledge falls short in value. The nature of belief and cognitive psychological research on memory, I claim, support the argument. I also show that not even the most appealing mode of knowledge is distinctively valuable.
Review: SAMe reduces symptoms in depression, osteoarthritis, and liver disease.

Source Citation Hardy M, Coulter I, Morton SC, et al. S-adenosyl-L-methionine for treatment of depression, osteoarthritis, and liver disease. Evidence Report/Technology Assessment no. 64. AHRQ publ...
"Bitch," Go Directly to Jail: Student Speech and Entry into the School-to-Prison Pipeline

This article demonstrates the close connection between student speech that the First Amendment protects (even for students in grades K-12) and penalties school authorities impose on speech they find controversial or offensive. The penalties include deprivation of instructional time – suspension, expulsion and assignment to alternative school for troubled and disruptive youth. The link between the exercise of First Amendment rights and school discipline that starts young people on the school-to-prison pipeline is even more dramatic when on-site police officers arrest students or schools refer them to the juvenile justice system for violating a school speech code – rules imposed by the school that may restrict expression the First Amendment protects in- and out- of school. Using national and local survey data that show the majority of students suspended from school are charged with nothing more than a code violation, often involving protected speech (such as cursing or criticizing a teacher), as well as reported cases about violations of student speech rights decided long after students had lost educational time, and the stipulations in the prolonged civil rights litigation in Meridian, Mississippi linking race, speech, in-school arrests and incarceration, the article demonstrates a nexus between the exercise of constitutional rights and the school-to-prison pipeline. The article also discusses penalties imposed for off-campus speech by students, especially online expression. The author argues that protected speech should never result in penalties that lead to adjudication as a delinquent or confinement in a juvenile facility.
The HLA Complex and Its Relationship to Rheumatic Diseases

SUMMARY AND CONCLUSIONS The HLA complex has been shown to be involved in the regulation of several aspects of the immune response, and has been shown to be associated with several rheumatologic diseases. The mechanisms by which HLA molecules predispose to disease has been an area of intense interest. Recent work has provided some possible explanations for the lack of absolute associations between a particular disease and a particular HLA antigen. There is now some evidence to suggest that specific epitopes rather than entire class I or II molecules may be responsible for disease predisposition. Furthermore, it appears that these epitopes may be transferred between different class I and II molecules by a mechanism known as gene conversion. Work evaluating the influence of other genes, such as those for the T cell receptor, on disease susceptibility has just begun. Many of the rheumatic diseases are quite diverse in their presentation. If only one of a heterogeneous group of diseases is associated with an HLA antigen, study of the entire group of diseases will of necessity dilute the association. Better definitions of clinical subsets should lead to improved correlations of HLA and disease. Little is known of etiologic agents or pathogenesis. As our knowledge of the interaction of HLA antigens, T cell receptors, and etiologic agents increases, we will come closer to an understanding of the mechanisms by which these molecules predispose to disease.
Schools, Worship, and the First Amendment

This five-part article examines the use of public school space for worship, arguing that the Second Circuit Court of Appeals was wrong in its First Amendment analysis related to the Free Speech Clause, the Establishment Clause, and the Free Exercise Clause in Bronx Household of Faith v. Board of Education of City of New York (Bronx Household IV) and in Bronx Household of Faith v. Board of Education of City of New York (Bronx Household V). Part I provides background to the issue of using public school space for religious worship, examining three contexts in which the U.S. Supreme Court has examined religion in public schools: 1) release time programs, 2) prayer, and 3) limited public forum cases. Part II of the article analyzes the Second Circuit's decision in Bronx Household IV, while part III discusses whether excluding worship services from a limited public forum in public schools violates the Free Speech Clause. Part IV discusses whether permitting worship services in public schools violates the Establishment Clause. Finally, part V discusses the Second Circuit's later decision in Bronx Household V, and examines whether exclusion of religious worship from a limited public forum violates the Free Exercise Clause.
Misalignment Sensitivity of Strongly Coupled Wireless Power Transfer Systems

A traditional strongly coupled magnetic resonance (SCMR) system is highly sensitive to the alignment between the transmitter and receiver elements, which is an issue that has limited their applicability in practical wireless power transfer systems. This paper proposes, for the first time, a novel set of SCMR-based topologies that are less sensitive to misalignment while providing large wireless powering efficiencies. Specifically, instead of using planar coils for the transmitter and the receiver, we connect two orthogonal coils together into a 3-D model to provide misalignment insensitivity. Three SCMR systems (standard SCMR, conformal SCMR, and hybrid SCMR systems) are studied and compared to the proposed 3-D SCMR system in terms of angular azimuth, angular elevation, and lateral misalignment. Also, the ranges of these SCMR systems are compared. It is shown that the proposed misalignment system achieves above 40% efficiency for the entire range of 360° of angular misalignment. Also, our results show that the proposed misalignment system provides longer range.
Arginine Arms T Cells to Thrive and Survive

A clear role for cellular metabolism in regulating immune cell function has recently been established. In a recent issue of Cell, Geiger et al. (2016) demonstrate a role for intracellular arginine abundance in T cells for the promotion of oxidative metabolism, increased cell viability, persistence, and in vivo antitumor response.
Curcumin enhances the apoptosis-inducing potential of TRAIL in prostate cancer.

B85 Tumorigenesis or carcinogenesis is a multi-step process that is induced primarily by carcinogens leading to the development of cancer. Extensive research in the last few years has revealed that regular consumption of certain fruits, vegetables and dietary products can reduce the risk of acquiring cancers. Curcumin (a diferuloylmethane, the yellow pigment in turmeric) possesses inhibitory effects on growth of a variety of tumor cells by reducing cell proliferation and inducing apoptosis. TRAIL induces apoptosis by binding to specific cell surface death receptors (TRAIL-R1/DR4 and TRAIL-R2/DR5). The objectives of this research were to investigate the mechanisms by which curcumin induced apoptosis in prostate cancer cells, and sensitized TRAIL-resistant LNCaP cells. Curcumin induced apoptosis in PC-3 cells and sensitize TRAIL-resistant LNCaP cells. Curcumin inhibited the expression of Bcl-2 and Bcl-XL, and induced the expression of Bax, Bak, PUMA, Bim, and Noxa in PC-3 and LNCaP cells. Treatment of prostate cancer cells with curcumin resulted in generation of reactive oxygen species and drop in mitochondrial membrane potential. Thus, curcumin sensitized TRAIL-resistant LNCaP cells to undergo apoptosis through multiple mechanisms i.e. regulation of Bcl-2 family members, up-regulation of death receptors and engagement of mitochondrial pathway. The ability of curcumin to enhance the apoptosis-inducing potential of TRAIL, and sensitize TRAIL-resistant LNCaP cells suggests that curcumin may induce fundamental alterations in cell signaling pathways leading to apoptosis. Overall, our results suggest that curcumin alone or in combination with TRAIL can be used as promising new candidate for prostate cancer prevention and/or therapy.
A detailed musculoskeletal study of a fetus with anencephaly and spina bifida (craniorachischisis), and comparison with other cases of human congenital malformations.

Few descriptions of the musculoskeletal system of humans with anencephaly or spina bifida exist in the literature. Even less is published about individuals in which both phenomena occur together, i.e. about craniorachischisis. Here we provide a detailed report on the musculoskeletal structures of a fetus with craniorachischisis, as well as comparisons with the few descriptions for anencephaly and with musculoskeletal anomalies found in other congenital malformations. We focused in particular on the comparison with trisomies 13, 18, and 21 because neural tube defects have been associated with such chromosomal defects. Our results showed that many of the defects found in the fetus with craniorachischisis are similar not only to anomalies previously described in the available works on musculoskeletal phenotypes seen in fetuses with anencephaly and spina bifida, but also to a wide range of other different conditions/syndromes including trisomies 13, 18 and 21, and cyclopia. The fact that similar anomalies are seen commonly not only in a wide range of different syndromes, but also as variants of the normal human population and as the ‘normal’ phenotype of other animals, supports Pere Alberch's unfortunately named idea of a ‘logic of monsters’. That is, it supports the idea that development is so constrained that both in ‘normal’ and abnormal development one sees certain outcomes being produced again and again because ontogenetic constraints only allow a few possible outcomes, thus also leading to cases where the anatomical defects of some organisms are similar to the ‘normal’ phenotype of other organisms. In fact, this applies not only to specific anomalies but also to general patterns, such as the fact that in pathological conditions affecting different regions of the body, one consistently sees more defects on the upper limbs than on the lower limbs. Such general patterns are, again, seen in the fetus examined for this study, which had 29 muscle anomalies on the right upper limb and 22 muscle anomalies on the left upper limb, vs. seven muscle anomalies on the right lower limb and two on the left lower limb. It is therefore hoped that this work, which is part of our effort to describe and compile information on human musculoskeletal defects found in a wide range of conditions, will contribute not only to a better understanding of craniorachischisis in particular and of human congenital malformations in general, but also to broader discussions on the fields of comparative anatomy, and developmental and evolutionary biology.
Boccaccio’s Mountain and the Voyage of the Soul

This chapter reflects on the significance of the voyage in the Second Day of the Decameron. In the Introduction to the Decameron, the famous simile comparing the interpretation of the text to the climbing of a mountain alludes to Dante’s Commedia and justifies the necessity of the plague in eschatological terms, thereby defining the reader’s experience as a sort of intellectual and spiritual progression. Similarly to Dante’s Commedia, the Decameron can be read as a journey toward the acquisition of knowledge. The Second Day of the Decameron and Boccaccio’s minor works can be used to explain this aspect insofar as they share the same modality of an allegorical voyage of the soul for the apprehension of knowledge.
MELK Promotes Melanoma Growth by Stimulating the NF-κB Pathway

Summary Melanoma accounts for more than 80% of skin cancer-related deaths, and current therapies provide only short-term benefit to patients. Here, we show in melanoma cells that maternal embryonic leucine zipper kinase (MELK) is transcriptionally upregulated by the MAPK pathway via transcription factor E2F1. MELK knockdown or pharmacological inhibition blocked melanoma growth and enhanced the effectiveness of BRAFV600E inhibitor against melanoma cells. To identify mediators of MELK function, we performed stable isotope labeling with amino acids in cell culture (SILAC) and identified 469 proteins that had downregulated phosphorylation after MELK inhibition. Of these proteins, 139 were previously reported as substrates of BRAF or MEK, demonstrating that MELK is an important downstream mediator of the MAPK pathway. Furthermore, we show that MELK promotes melanoma growth by activating NF-κB pathway activity via Sequestosome 1 (SQSTM1/p62). Altogether, these results underpin an important role for MELK in melanoma growth downstream of the MAPK pathway.
Frequency dependent DQE of photon counting detector with spectral degradation and cross-talk

Charge sharing and migration of scattered and fluorescence photons in photon counting detector (PCD) degrade the detector's energy response and cause a single photon to be potentially counted as multiple events in neighboring pixels, leading to correlations of signal and noise. Signal and noise correlations in conventional linear, space-invariant imaging can be usefully characterized by the frequency dependent detective quantum efficiency, DQE(f). The situation is complicated in the PCDs by the spectral dimension. We analyze DQE(f) of CdTe PCDs using a spatial domain method starting from a previously described computation of spatio-energetic cross talk. DQE(f) is estimated as the squared signal-to-noise ratio of the estimate of the amplitude of a small-signal sinusoidal modulation in the object at a frequency f by a given system compared to that with an ideal detector. DQE(f) for spectral and effective monoenergetic imaging are estimated using a multi-pixel Cramer-Rao lower bound for CdTe detectors of different pixel pitch. For a 120 kVp incident spectrum, DQE(0) for a spectral task was ~18%, 25% and 34% for 250 μm, 500 μm and 1 mm pixels, respectively. Positive correlation between same basis material estimates in neighboring pixels from the spatio-energetic cross-talk causes this effect to have least impact at the detector's Nyquist frequency. For effective monoenergetic imaging, DQE(0) at the optimal energy is relatively tolerant of spectral degradation (85-92% depending on pixel size), but is highly dependent on effective energy, with maximum variation (in 250 μm pixels) of 25-85% for effective energies between 30 to 120 keV.
Capillary microextraction of volatiles device for enhanced BTEX vapors sampling based on a phenyl modified PDMS sol-gel adsorption phase.

Abstract A novel phenyl modified PDMS (PhPDMS) sol-gel adsorption phase was developed for use with the capillary microextraction of volatiles (CMV) device, and determined to provide significant enhancement in BTEX recoveries when sampling trace (ng) amounts of these volatiles at ambient conditions. The previously reported reusable PDMS-CMV device has been demonstrated to rapidly and efficiently extract target compound's vapors in forensic and environmental applications. An improved recovery for VOCs was achieved with a cryofocusing system while extracting at −10 °C, but it was found to be impractical for field sampling. This report details a modification to the CMV's chemistry, by the successful introduction of phenyl groups to the PDMS sol-gel adsorption phase, allowing enhanced performance at ambient extraction conditions. Higher average recoveries, determined through a broad concentration range, were demonstrated for PhPDMS-CMV over its original PDMS-CMV, from cans simulating a closed space set-up. Within 7.8 (±10%) and 3.5 (±6%) folds higher for benzene and toluene, respectively and 2 (±2%) folds for ethylbenzene and xylenes. Significant higher retaining capabilities were demonstrated also at the more challenging set-up, simulating an open space environment. Whereas, benzene had completely breakthrough the PDMS-CMV, its reliable detection was still confirmed with PhPDMS-CMV pumping at 2 L or 6 L air, concentration dependent. At least 50 folds (±26%) more toluene was retained with PhPDMS-CMV at 6 L air than with PDMS-CMV. The enhanced overall performance lead to determination of trace LODs with the new CMV of 0.002, 0.00035 and 0.00015 ppm for benzene, toluene, ethyl benzene and xylenes, respectively. As proof of concept, for the first time solvent extraction is presented for the new CMV as an alternative to thermal desorption extraction. Extraction efficiencies of 60% for TEX, and lower concentration dependent for benzene, were demonstrated with the ease and rapid application of 100 μL acetone through the device. The improvements described in this study continues to build on the potential for the use of the reusable new CMV device by expanding its possible potential applications for fast and sensitive air sampling of VOCs. The solvent extraction step may offer compatibility with LC-based systems.
Preliminary studies of honey queen bee conditions using Cyranose 320 nose technology

Over the last ten years, the bee keeping industry has been struggling to understand and stop the sudden widespread loss or collapse of honey bee colonies, known collectively as Colony Collapse Disorder (CCD), in the U.S. and around the world. While honey bee colonies experience many stressors that could cause a colony to collapse, we are focusing on the quality, health and reproductive ability of honey bee queens. The purpose of this line of research is to identify relationships between the pheromone signatures of honey bee queens and the quality of honey bee queens. The ultimate goal of this research is to find a reliable, non-invasive tool that does not harm the queen, but still allows beekeepers to make informed decisions about purchasing honey bee queens and deciding when to replace a queen bee before a colony collapses. In this portion of the research, we use an electronic nose (e-nose) device, which is a device that digitizes smells. The scope of this paper is to determine whether an e-nose device is viable for our research, and if so, to determine the best way to configure the settings to improve data collection. Also, to gather data on queen bee pheromones production was considered since that is an indicator of a queen bee's reproductive ability. We were able to use the e-nose device to digitize pheromone signatures from 20 queen bees. Using Microsoft excel and R programming language, we were able to see patterns that will be useful in configuring the e-nose device for future research. We also noticed an early indication that the e-nose can distinguish between a healthy bee and a sick bee.
Aesthetic/Erotic Intuition: Hölderlin, Shelley, and the Islands of the Archipelago

In this chapter I argue that we can best read an enigmatic scene of erotic encounter from Holderlin’s Hyperion through comparison with a paradigm of aesthetic production outlined by Schelling at the end of System of Transc endental Idealism. In a sense, Hyperion constructs his lover, Diotima, as an aesthetic object. We thus find in the scene an erotic variation of Schelling’s concept of the transformation of “intellectual intuition” into “aesthetic intuition .” I compare this scene from Hyperion with Percy Shelley’s Epipsychidion (1821), a poem that likewise includes a mysterious erotic encounter on a Greek island. The comparison allows us to read an erotically charged version of intellectual intuition within Shelley’s poem as well.
Ceramic and Plastic Pin Grid Array Technology

The technology surrounding integrated circuits has improved drastically since first introduced in 1959. The desire to miniaturize circuits, coupled with increased speed and decreased energy consumption requirements has led to present day highly integrated circuits. To take advantage of the integration enhancements at the die level, much attention is focused on the supporting package performance.
Gas liquid chromatographic analysis of amino acids in the hemolymph of Oncopeltus fasciatus.

Aminosauren in Proben von 2 μl Haemolymphe von gefutterten und hungerndenOncopeltus fasciatus wurden mittels Gaschromatographie analysiert und gezeigt, dass dieses Insekt die Konzentration mehrer Aminosauren aus Haemolymphe regulieren kann.
Gramian-based model-order reduction of constrained structural dynamic systems

This study discusses model reduction techniques for second-order index 3 descriptor systems using the balanced truncation methods; in particular, linearised equations of motion with holonomic constraints are considered which arise in mechanics and multibody dynamics. It is shown that the index 3 system can be converted into an equivalent form of index 0 system by projecting it onto the hidden manifold. When model reduction is applied to the projected system, explicit formulation of the projected system is not required. The low-rank alternating direction implicit iteration is also discussed for solving the projected Lyapunov equations of the underlying descriptor system efficiently in an implicit way. The theoretical results are illustrated by numerical experiments.
Debt Collecting, Disappearance, Necromancy: A Response to John Beusterien

Jones’s response to John Beusterien addresses some of the lurking assumptions he identifies in Iberian Studies scholarship and its challenge of addressing the legacy and representation of black Africans—genealogical, historical, or otherwise—in early modern Spain and our present era. Via his central ideological concepts of debt collecting and necromancy, Jones’s counterpoint to “necrocapitalism” or “necropolitics” utilizes these terms in order to employ the lens of African cultural survivals and to return, on the one hand, and to animate, on the other hand, an inherent agential voice to those African-descended persons bureaucratically filtered, silenced, and regularized in slave owner’s inventories and wills as well as dossiers from the Inquisition.
Abstract 122: Markers of Coagulation and Hemostatic Activation Identify Embolic Stroke of Undetermined Source (ESUS) Patients who are at Risk of Recurrent Thrombotic Events on Antiplatelet Therapy: A Validation Study

Introduction: Markers of coagulation and hemostatic activation (MOCHA) have previously been shown to identify ESUS patients who are more likely to have subsequent diagnosis of atrial fibrillation (...
Dialectics of dissociation

In their discussion of ‘dissociation’, Ibert et al. ((2019) Geographies of dissociation: value creation, ‘dark’ places, and ‘missing’ links. Dialogues in Human Geography.) explore the negative side of branding—that is, the efforts companies take to avoid being identified with problems such as labor exploitation or environmental degradation. Because the introduction of unwanted associations into the semiotic circuit threatens the value of brands, brand owners engage in both proactive and reactive relational work to insulate brand assets from such threats. In this commentary, I explore the development of supply chain corporate social responsibility through the lens of dissociations. Civil society organizations, such as trade unions, student groups, faith-based organizations, and so on, that target brands by highlighting problems in their supply chains are engaged in a struggle over value. One way that brand owners try to counter this reputational threat is by accepting, albeit to varying degrees, the princi...
The Two Faces of Liberalism: How the Hoover-Roosevelt Debate Shapes the 21st Century

Review of: "The Two Faces of Liberalism: How the Hoover-Roosevelt Debate Shapes the 21st Century," by Gordon Lloyd.
Neoliberal feminism in contemporary South Korean popular music: discourse of resilience, politics of positive psychology, and female subjectivity

This paper examines how South Korean popular music (K-pop) promotes neoliberal feminism by a discourse of resilience. In a therapeutic narrative of overcoming obstacles and achieving goals, K-pop videos deliver a hegemonic message that individuals have to be responsible for their success and well-being rather than blaming external, institutional conditions. While ostensibly promoting female empowerment, the videos update and reinforce patriarchal gender norms and expectations. To substantiate this point, I analyze music videos of the most successful K-pop group, Girls’ Generation’s “Into the New World” (2007) and “All Night” (2017) to investigate how they promote resilience discourse along with neoliberal positive psychology as a hegemonic ideal of female subjectivity
OBSERVATIONS ON THE KALLIAPSEUDID TANAIDACEA (CRUSTACEA: MALACOSTRACA: PERACARIDA) FROM THE NORTHWESTERN ATLANTIC, WITH AN ILLUSTRATED KEY TO THE SPECIES

New information for the kalliapseudid Tanaidacea occurring in the northwestern Atlantic is presented and discussed, including data on range extensions and new depth ranges for 4 species. The taxa studied came from the shelf and coastal waters of the southeastern United States, Puerto Rico and Trinidad. The occurrence of Mesokalliapseudes baha- mensis Sieg is extended from the Bahamas and Belize to the coastal waters of East and Gulf coasts (South Carolina to West Florida). The range of Psammokalliapseudes granulosus Brum is expanded northward into the eastern Gulf of Mexico and new locality records for this species are established for Tobago and Puerto Rico. Mesokalliapseudes brasiliensis (Bacescu), previously known from the southwestern Atlantic off Brazil, is reported from the coastal waters off Trinidad. The range of Tanapseudes gutui Hansknecht, Heard, and Bamber is expanded northward into the eastern Gulf of Mexico. New depth ranges are established for Alokalliapseudes macsweenyi (Drumm) (82 m), M. bahamensis (52 m), P. granulosus (53 m), and T. gutui (82 m). An offshore form of A. macsweenyi occurs at depths ranging from 10-82 m on the inner and mid con- tinental shelf off the west coast of Florida (Gulf of Mexico); it differs from the coastal form by the shape and dentition of the male and female chelipeds. Synonymies, diagnoses, life history remarks, and an illustrated key to the seven kalliapseudid species known from the NW Atlantic are presented.
Advanced control solutions for enhanced resilience of modern power-electronic-interfaced distribution systems

Modern power delivery systems are rapidly evolving with high proliferation of power-electronic (PE)-interfaced distributed energy resources (DERs). Compared to the conventional sources of generation, the PE-interfaced DERs, e.g., solar and wind resources, are attributed substantially different characteristics such as lower overload capability and limited frequency response patterns. This paper focuses on effective management and control mechanisms for PE-interfaced DERs in power distribution systems with high penetration of renewables, particularly under fault, voltage-sag, load variations, and other prevailing conditions in the grid. Aiming at the solutions to enhance the system performance resilience, we introduce an advanced model predictive control (MPC) based scheme to control the DER units, minimize the impact of transients and disruptions, speed up the response and recovery of particular metrics and parameters, and maintain an acceptable operation condition. The performance of the suggested control scheme is tested on a modified IEEE 34-bus test feeder, where the proposed solution demonstrates its effectiveness to minimize the system transient during faults, with an enhanced grid-edge and system-wide resilience characteristics in voltage profiles.
Millimeter-wave spectroscopy of the chlorine isotopologues of 2-chloropyridine and twenty-three of their vibrationally excited states

Abstract A combined total of 25 vibrational states of 2-chloropyridine (C5H4NCl, μa = 3.07 D, μb = 1.70 D), including states for both chlorine isotopologues, have been least-squares fit to sextic, A-reduced Hamiltonians with low error (
The Deception Plans of the ‘Aristocratic Revolution’: ‘Von’ Hayek I, II and III

Logic and self-interested introspection (and/or deception-driven delusion) reveals that ‘von’ Hayek (I) was disinterested, devoted to liberty, and projected the ‘definite impression of austere and magisterial eminence, both intellectually and morally.’ The evidence, however, suggests that there were two more Hayeks: Hayek (II), a crude, aristocratic, Jew-hating racist; plus Hayek (III), a ‘Three-Fifths Compromise’ White Terror promoter. Whether or not he was a diagnosed schizophrenic, Hayek was funded by the Tobacco, Obesity and Fossil Fuel lobby—as are his epigones. The Austrian School of Economics maintains a ‘united front’ with ‘Neo-Nazis,’ and Mises had aspired to be the intellectual Fuhrer of a Nazi-Classical Liberal Pact. Mises and Hitler were funded from the same employer trade union sources. The Road to Serfdom was published on 10 March 1944; the liberation of Europe began three months later. Both were successful because of a standard military tactic: deception plans. Hayek and Mises promoted the deflation that undermined democracy and allowed Hitler to seize power. The Allies expected that the Austro-Germans were expecting them to land in Pas-de-Calais and so pandered to that psychological predisposition. Hayek knew that many British neoclassical economists were concerned that the Great Depression led to both protectionist pressures and extensive economic planning and so pandered to those psychological predispositions, while blaming the Third Reich not on his own proto-Nazi family but on socialists.
Retinal Vascular Changes on Optical Coherence Tomography Angiography and Ultra-widefield Fluorescein Angiography in Patients With Chronic Leukemia

Purpose:This article describes pathological retinal vascular changes on multimodal imaging in patients with chronic leukemia.Methods:A prospective, observational study was conducted. Patients with ...
Pasantías Formativas del Instituto de Montaña: Generación de Información y Capacidades

The Andean region faces the imminent challenge that involves the generation of actions that favorthe adaptation to and mitigation of the effects that climate change is producing. The Andean ecosystems and the human populations that are part of them are highly vulnerable to the climatic variability that we are facing. To develop these adaptation tools, the promotion of quality scientific research is crucial, as well as the recovery and implementation of the ancestral knowledge developed over thousands of years by the human populations that inhabit this changing territory. To carry out these purposes at a local scale in the surroundings of the Cordillera Blanca, a series of information gaps were detected that needed to be closed, prioritizing the lack and dispersion of baseline environmental information at a local scale that would serve to carry out studies and research that result in an improvement of the living conditions of the high Andean populations. Also, the Mountain Institute (TMI) detected the need to raise and support the talent and motivation of young graduates of the Santiago Antunez de Mayolo National University (UNASAM). These university internships last between six and eight months and constitute a first work contact, an experience of working with rural communities, the possibility of being part of an interdisciplinary team, as well as the opportunity to receive specialized training in topics of the work carried out. In the framework of the program, the interns have carried out basic studies at an ecological and hydrological level, treatment and systematization of hydrometeorological information collected by the Center for Environmental Research for Development (CIAD) of the UNASAM, surveys and treatment of socio-economic information and modeling and assessment of the danger from glacial avalanches. The results and information gathered have served as the basis for more specific studies regarding the implementation of Ecosystem Service Compensation Mechanisms (MRSE) and for the drafting of various profiles of development projects such as Public Investment Projects (PIP), among others.
Clinical and molecular correlates of PD-L1 expression in patients with lung adenocarcinomas.

Background Programmed death-ligand 1 (PD-L1) expression is the only FDA-approved biomarker for immune checkpoint inhibitors (ICIs) in patients with lung adenocarcinoma, but sensitivity is modest. Understanding the impact of molecular phenotype, clinical characteristics, and tumor features on PD-L1 expression is largely unknown and may improve prediction of response to ICI. Patients and methods We evaluated patients with lung adenocarcinoma for whom PD-L1 testing and targeted next-generation sequencing (using MSK-IMPACT) was performed on the same tissue sample. Clinical and molecular features were compared across PD-L1 subgroups to examine how molecular phenotype associated with tumor PD-L1 expression. In patients treated with anti-PD-(L)1 blockade, we assessed how these interactions impacted efficacy. Results A total of 1586 patients with lung adenocarcinoma had paired PD-L1 testing and targeted next-generation sequencing. PD-L1 negativity was more common in primary compared to metastatic samples (P Conclusion PD-L1 expression and association with ICI response vary across tissue sample sites. Specific molecular features are associated with differential expression of PD-L1 and may impact the predictive capacity of PD-L1 for response to ICIs.
The relationship between diabetes and depressive symptoms in men with or at risk of HIV infection

OBJECTIVES The aim of the study was to compare the prevalence of comorbid diabetes and depressive symptoms in men living with HIV (MLWH) with that in men without HIV infection and to determine associations between glycaemic control and depressive symptoms. METHODS Participants included 920 MLWH and 840 men without HIV infection from the Multicenter AIDS Cohort Study (MACS) with available data regarding glycaemic status [categorized as normal for fasting blood glucose (FBG) < 100 mg/dL, prediabetes for FBG 100-125 mg/dL, and diabetes, defined by self-report, diabetes medication use or FBG ≥ 126 mg/dL on at least two consecutive visits, with diabetes classified as controlled if Hemoglobin A1c (HbA1C) < 7.5% and uncontrolled if HbA1C ≥ 7.5%]. Depressive symptoms were assessed using the Center for Epidemiologic Studies Depression (CES-D) score, with CES-D ≥ 16 scores classified as elevated depressive symptoms. A modified Poisson regression model with robust variance was used and adjusted for covariates including HIV serostatus. RESULTS Compared to men without HIV infection, MLWH had a higher mean CES-D score, but a similar prevalence of diabetes (11.3% versus 12.8%, respectively; P = 0.33). The concomitant prevalence of diabetes and elevated depressive symptoms did not differ by HIV serostatus (P = 0.215). In an adjusted analysis, men with uncontrolled diabetes had a greater prevalence of depressive symptoms compared to men with normoglycaemia (prevalence ratio = 1.43; 95% confidence interval 1.11, 1.84). The association between glycaemic status and depressive symptoms did not differ by HIV serostatus (P = 0.22 for interaction). CONCLUSIONS Both controlled and uncontrolled diabetes were independently associated with a greater prevalence of depressive symptoms, regardless of HIV serostatus. These results highlight the importance of identifying depression in people with diabetes.