cssi/SciSciGPT-SciSciNet huggingface dataset:
Impediments to Wildlife Disease Surveillance, Research, and Diagnostics

There is a recognized need for increased wildlife disease surveillance and research related to understanding the epidemiology and control of emerging wildlife and zoonotic diseases. Although both passive and active surveillance strategies can and have been effectively used with wildlife, some unique problems are often encountered. These can include limitations related to case acquisition and under-reporting, difficulty in designing sampling strategies that adequately represent the population of interest, the lack of properly validated diagnostic tests, problems related to data interpretation due to missing or inaccurate denominator data, and the lack of an existing wildlife surveillance infrastructure. Many of these same problems are often encountered in field research, which can be further complicated by the complexity and scale of the natural systems in which this work takes place. Although such studies may be difficult, there are numerous examples of success and our understanding of wildlife and wildlife-related zoonotic and emerging disease continues to grow.
Foul Play: Soccer's "Infamous Thespians" and the Cultural Politics of Diving

“Diving” or “simulation,” according to FIFA’s Laws of the Game, is an attempt to deceive referees by feigning injury or pretending to have sustained a foul. When examined as a performance strategy, simulation in football reveals a tacit reliance on the aesthetic criteria of realist acting and incites an antitheatrical discourse that services xenophobic anxieties in the new Europe.
Abstract 225: Protein tyrosine kinase 6 directly phosphorylates p130 CRK-associated substrate to promote peripheral adhesion complex formation and cell migration

Protein tyrosine kinase 6 (PTK6) is a nonmyristoylated intracellular tyrosine kinase evolutionarily related to Src kinases. Aberrant PTK6 expression and intracellular localization have been detected in human prostate tumors. Although the majority of total PTK6 is localized within the cytoplasm of PC3 cells, a human prostate cancer cell line, we found that the activated pool of PTK6 phosphorylated on tyrosine residue 342 is localized at the membrane. Ectopic expression of membrane targeted PTK6 leads to enhanced activation of PTK6 at the membrane and the formation of 6 to 12 striking focal adhesion-like complexes localized at the periphery of each cell, termed peripheral adhesion complexes. Using confocal microscopy, we show that p130 CRK-Associated Substrate (p130CAS), FAK, Paxillin and Vinculin, as well as increased levels of tyrosine phosphorylated proteins and active PTK6 are localized within the induced peripheral adhesion complexes. We determined that peripheral adhesion complex formation is dependent upon PTK6 tyrosine kinase activity. We demonstrate that p130CAS is a novel direct substrate of PTK6 that works as a crucial adapter protein in PTK6 mediated formation of peripheral adhesion complexes. We found that activation of ERK5 signaling downstream of p130CAS is indispensible for this process. Knockdown of p130CAS attenuates oncogenic signaling induced by membrane targeted PTK6, including ERK5 and AKT activation. We show that formation of peripheral adhesion complexes is associated with enhanced cell migration. PC3 cells expressing membrane targeted PTK6 exhibit increased migratory ability, which can be impaired by knockdown of p130CAS or ERK5. In contrast, knockdown of endogenous PTK6 in PC3 cells reduces cell migration, which is accompanied with decreased phosphorylation of p130CAS and ERK5. Our study reveals a novel function for PTK6 at the plasma membrane, and suggests that a PTK6-p130CAS-ERK5 signaling cascade plays an important role in cancer cell migration and invasion. Citation Format: {Authors}. {Abstract title} [abstract]. In: Proceedings of the 103rd Annual Meeting of the American Association for Cancer Research; 2012 Mar 31-Apr 4; Chicago, IL. Philadelphia (PA): AACR; Cancer Res 2012;72(8 Suppl):Abstract nr 225. doi:1538-7445.AM2012-225
Morphology of the Internal Reproductive System of the Adult Female Army Cutworm, Euxoa auxiliaris

The morphology of the internal reproductive system of the adult female army cutworm, Euxoa auxiliaris (Grote) (Lepidoptera: Noctuidae), and the spermatophore, is described and illustrated. The study shows the basic similarities and differences between the army cutworm and some other noctuid species previously studied.
From Flux Quantization to Magnetic Monopoles

Superconductive technologies developed over the last decade now allow detailed observation of flux quantization in five centimeter diameter rings. The theoretical similarities between flux quantization and Dirac magnetic charges make superconductive systems natural detectors for these elusive particles. Recent work on Grand Unification theories, the topic of this workshop, strongly suggests the existence of stable supermassive magnetically charged particles. These particles would be nonrelativistic, weakly ionizing, and very penetrating; and thus may have eluded previous searches. A new superconductive detector designed to look for an extraterrestrial flux of such particles has been operating for more than six months and the first results include a single event. It is consistent in magnitude with the passage of a particle possessing a single Dirac unit of magnetic charge.
Wednesday, August 11, 2010—New York City

Robert Cornelius Brown sat waiting in the comfortable, burgundycolored leather booth at La Fia’s, an upscale Italian restaurant in mid-Manhattan. He had barely lifted the glass of water to his lips, when his old friend Jason Slaughtery walked through the door and removed his sunglasses to allow his eyes to adjust to the dim light.
Retrodirective antenna technology for CubeSat networks

In the spring of 2003, the University of Hawaii (UH) began participation in the University NanoSat Program, a multi-university effort sponsored by NASA and the USA Air Force Research Laboratories to encourage small-satellite research and development. Undergraduate engineering students at UH have been involved in small-satellite development for the past two years, particularly for a class of picosatellites known as CubeSat, which has a mass no greater than 1 kg and a volume of 1000 cm/sup 3/.
Características de la agrobiotecnología

Las semillas transgenicas, una innovacion biotecnologica, representan tanto promesas como peligros para los agricultores, los consumidores y el ambiente...y vislumbran ganancias multimillonarias para las empresas transnacionales. Pero como tecnica nueva, todavia no se sabe las consecuencias sobre el largo plazo ni aun el plazo inmediato, pues existen muchos peligros para la salud humana y el ambiente. Las politicas neoliberales y transnacionales destruyen la soberania alimentaria, por eso deben sentir el impacto de los movimientos ambientalistas, laborales y campesinos, de modo que reorienten su trabajo para el beneficio de toda la sociedad y de la naturaleza.
Modeling Topological Relationships between Fuzzy Spatio-Temporal Objects

Topological relationships between spatio-temporal objects are the most fundamental elements in spatio-temporal database systems, GIS, and image database systems. The research issue of modeling topological relationships has increasingly attracted attention, especially for querying of spatio-temporal objects and reasoning of topological relationships. Currently, topological relationship operating on spatio-temporal objects with precisely defined boundaries has been well studied. However, in the real world, spatio-temporal objects are not always crisp but with the nature of fuzziness and imprecision. Therefore, how to model topological relationship between fuzzy spatio-temporal objects is a significant topic and needs more investigations. This paper presents a study on modeling topological relationships between fuzzy spatio-temporal objects. Firstly, we give a model of fuzzy spatio-temporal objects in three-dimensional space and define those objects as moving fuzzy points , moving fuzzy lines , and moving fuzzy regions . On this basis, we propose a model for identifying basic topological relations between fuzzy spatio-temporal objects. Furthermore, in order to describe the evolution of basic topological relations over time, we give a model of complex topological relationships which are the sequences of basic relationships. The benefit of this model is that the complex topological relationships can be used as fuzzy spatio-temporal query operators in query languages. Finally, we provide some query examples to demonstrate fuzzy spatio-temporal queries in spatio-temporal database.
Probe Decomposition of Methylammonium Lead Iodide Perovskite in N2 and O2 by in Situ Infrared Spectroscopy.

Packaging methylammonium lead iodide perovskite (MAPbI3)-based solar cells with N2 or dry air is a promising solution for its application in outdoor photovoltaics. However, the effect of N2 and O2 on the decomposition chemistry and kinetics of MAPbI3 is not yet well-understood. With in situ Fourier transform infrared spectroscopy measurements, we show that the effective activation energy for the degradation of MAPbI3 in N2 is ∼120 kJ/mol. The decomposition of MAPbI3 is greatly accelerated by exposure to O2 in the dark. As a result of the synergistic effect between O2 and a HeNe laser (633 nm), the degradation rate is further increased with photon flux. This synergistic effect reduces the effective activation energy of degradation of MAPbI3 to ∼50 kJ/mol. The solid decomposition products after annealing in N2 and O2 at 150 °C or below do not have absorbance between 650 and 4000 cm–1.
La piel humana en la narrativa corta tradicional

As an attribute of the human being, the skin is polyvalent; it forms the basis for beliefs about immortality, about individual temperament, and about the invulnerability of legendary warriors. These beliefs lie in their turn at the origin of many traditional folktales. The perception of the renewal each year of the earth's vegetation, and of the skins of reptiles, is suggestive for the primitive narrator: the macrocosm also has a covering of skin. So one may identify a wide spectrum of related stories and legends, sometimes facetious, sometimes illustrative of the powers of the Devil.
WiP Abstract: Platform for Security-Aware Design of Human-on-the-Loop Cyber-Physical Systems

Cyber-Physical Systems (CPS) are commonly supervisory controlsystems where a human-on-the-loop (HOL) supervises one or moreautonomous systems, while embedded autonomy allows the operatorsto intermittently attend to the system and other tasks. Thus,it is imperative that the design of any security-aware CPS considersthe impact of the human interaction with the system onsecurity guarantees. Yet, there has been very little work on designof Human-CPS that promotes human situational awareness for enhancedsystem performance, particularly in terms of cyber-physicalsecurity and real-time defense against attacks. One of the mainobstacles to the rapid advancement of this field is the scarcity oftestbeds for evaluating security-aware Human-CPS interactions.We present RESCHU-SA, an extendable virtual platform thatfacilitates studying the impact that HOL has on security of CPSwith varying levels of autonomy. It allows users to analyze howinductive reasoning and ability to provide context, particularlyduring an attack, affects the overall CPS security guarantees. Theproposed platform is an extension of the Research Environmentfor Supervisory Control of Heterogeneous Unmanned Vehicles(RESCHU) simulation environment, previously used in variousapplications including studies focused on supervising UnmannedAerial Vehicles (UAVs) missions and evaluation of interface usability.
SWAY, ROLL, AND YAW MOTION COEFFICIENTS BASED ON A FORWARD SPEED SLENDER-BODY THEORY--PART 2

A comparison between theory and experiment is given for the roll-sway, sway-yaw added-mass, and damping coupling coefficients. The theory was derived by Troesch (1980), who followed an approach similar to that given by Ogilvie and Tuck (1969) for the heave and pitch coefficients. The experiments were presented by the Society of Ship Research of Japan in 1976.
Laparotomy and intraoperative enteroscopy for obscure gastrointestinal bleeding before and after the era of video capsule endoscopy and deep enteroscopy: A tertiary center experience.

Abstract Background To evaluate roles of intraoperative endoscopy (IOE) in management of severe obscure GI bleeding (OGIB) before vs. after introduction of video capsule endoscopy (VCE) and deep enteroscopy (DE). Methods We retrospectively reviewed prospectively collected data of patients undergoing IOE for severe OGIB in a tertiary referral center. Results 52 patients had laparotomy/IOE for OGIB, 11 pre and 41 post VCE/DE eras. In the pre VCE/DE era, 36.4% (4/11) had preoperative presumptive diagnoses while in the post VCE/DE era presumptive diagnoses were made in 48.8% (20/41) (p = 0.18). Preoperative evaluation led to correct diagnoses in 18.2% (2/11) in the pre and 51.2% (21/41) in the post VCE/DE era (p = 0.09). Vascular lesions and ulcers were the most common diagnoses, but rebleeding was common. No rebleeding was found among patients with tumors, Meckel's diverticulum, and aortoenteric fistula. Conclusions Presumptive diagnoses in the post VCE/DE era were usually accurate. If VCE or DE are negative, the probability of negative IOE is high. Patients with tumors and Meckel's diverticulum were the best candidates for IOE.
Tunable fluorescence quenching near the graphene-aqueous interface.

Abstract With increased interest in graphene-based sensors for biomolecules and other targets, we investigated the impact of ionic strength on the steady-state emissions from fluorescein labels on proteins adsorbing on pristine CVD (chemical vapor deposited)-graphene on a silica support. Using the model system of fluorescein-tagged fibrinogen we demonstrated that, for fluorescein tags on adsorbed fibrinogen, emission intensity was very sensitive to the salt concentration. This behavior was not seen for fluorescein-tagged fibrinogen in solution. We demonstrated that fluorescein “quenching” in this system was a result of fluorescein’s pH sensitivity: with changes in salt concentration, near-surface fluorescein experiences either the neutral bulk pH or, with a negatively charged surface, an acidic environment. The findings carry the important implication that the aqueous environment near silica-supported graphene is substantially acidic as a result of near-surface negative charge. This further implies, because of the purity of the graphene in this study and its lack of oxidation, that negative charge arises from ion adsorption and/or from the underlying silica support, which may be hydrated and present dissociated surface silanols. That is, the electrostatic potential from silica beneath the graphene may pass through the graphene, much as van der Waals interactions have been proven to do. Results were semi-quantitatively consistent with calculations that employed a Guoy Chapman model of the interface and the established pKa of the fluorescein. While these findings were obtained with adsorbed proteins, similar fluorescence quenching would be expected for any fluorescein-tagged species in the vicinity of silica-supported graphene. Thus, because of the negative charge at the aqueous graphene interface, ionic strength can be exploited as means of creating a molecular ruler of fluorescein emissions, and the emissions can be assessed within different distances, corresponding to the Debye length, from the graphene interface.
Exploiting Dark Fluorophore States to Implement Resonance Energy Transfer Pre-Charge Logic

As lithographic feature sizes approach fundamental scaling limits, a variety of computational domains remain incompatible with integrated circuits merely due to their operating principles. Resonance energy transfer (RET) logic offers a molecular-scale solution for accessing these untapped domains. This emerging technology uses self-assembled networks of fluorescent molecules to perform computation at scales far below the diffraction limit and in environments that preclude silicon electronics. In this article, the authors propose a new form of RET logic design that yields a library of nonlinear logic gates that can be cascaded to build more complex integrated molecular circuits.
The impact of fillers on lineup performance

Filler siphoning theory posits that the presence of fillers (known innocents) in a lineup protects an innocent suspect from being chosen by siphoning choices away from that innocent suspect. This mechanism has been proposed as an explanation for why simultaneous lineups (viewing all lineup members at once) induces better performance than showups (one-person identification procedures). We implemented filler siphoning in a computational model (WITNESS, Clark, Applied Cognitive Psychology 17:629–654, 2003), and explored the impact of the number of fillers (lineup size) and filler quality on simultaneous and sequential lineups (viewing lineups members in sequence), and compared both to showups. In limited situations, we found that filler siphoning can produce a simultaneous lineup performance advantage, but one that is insufficient in magnitude to explain empirical data. However, the magnitude of the empirical simultaneous lineup advantage can be approximated once criterial variability is added to the model. But this modification works by negatively impacting showups rather than promoting more filler siphoning. In sequential lineups, fillers were found to harm performance. Filler siphoning fails to clarify the relationship between simultaneous lineups and sequential lineups or showups. By incorporating constructs like filler siphoning and criterial variability into a computational model, and trying to approximate empirical data, we can sort through explanations of eyewitness decision-making, a prerequisite for policy recommendations.
Examining the Environmental Characteristics of Shared Leadership in a Sport-for-Development Organization

To promote community development, sport-for-development (SFD) organizations strive to build local leadership that fosters long-term sustainability. Although shared leadership (SL) structures are particularly effective in these settings, there has been limited attention to SL within the SFD context, especially from a multilevel perspective. While previous studies of leadership in sport have primarily focused on the individual traits of leaders, multilevel analysis is required to understand how environmental characteristics relate to leadership development. This qualitative case study analyzes the development and deployment of SL in an American SFD organization. Interviews, observations, and document analysis are used to generate data, and theoretical thematic analysis is used to identify key themes related to the environmental characteristics of SL. Results highlight how environmental characteristics are related to SL, as well as group and task characteristics. The discussion integrates these findings with...
7B2 chaperone knockout in APP model mice results in reduced plaque burden.

Impairment of neuronal proteostasis is a hallmark of Alzheimer’s and other neurodegenerative diseases. However, the underlying molecular mechanisms leading to pathogenic protein aggregation, and the role of secretory chaperone proteins in this process, are poorly understood. We have previously shown that the neural-and endocrine-specific secretory chaperone 7B2 potently blocks in vitro fibrillation of Aβ42. To determine whether 7B2 can function as a chaperone in vivo, we measured plaque formation and performed behavioral assays in 7B2-deficient mice in an hAPPswe/PS1dE9 Alzheimer’s model mouse background. Surprisingly, immunocytochemical analysis of cortical levels of thioflavin S- and Aβ-reactive plaques showed that APP mice with a partial or complete lack of 7B2 expression exhibited a significantly lower number and burden of thioflavin S-reactive, as well as Aβ-immunoreactive, plaques. However, 7B2 knockout did not affect total brain levels of either soluble or insoluble Aβ. While hAPP model mice performed poorly in the Morris water maze, their brain 7B2 levels did not impact performance. Since 7B2 loss reduced amyloid plaque burden, we conclude that brain 7B2 can impact Aβ disposition in a manner that facilitates plaque formation. These results are reminiscent of prior findings in hAPP model mice lacking the ubiquitous secretory chaperone clusterin.
Dminating sets for outerplanar graphs

We provide lower and upper bounds for the domination numbers and the connected domination numbers for outerplanar graphs. We also provide a recursive algorithm that finds a connected domination set for an outerplanar graph. Finally, we show that for outerplanar graphs where all bounded faces are 3-cycles, the problem of determining the connected domination number is equivalent to an art gallery problem, which is known to be NP-hard.
Bulimia treated with imipramine: A placebo-controlled, double-blind study

Bulimia, the syndrome of compulsive binge eating, is a common and often severe disorder frequently resistant to known therapies. Recent evidence suggesting a link between bulimia and affective disorder prompted the authors to perform a double-blind study of imipramine versus placebo with 22 chronically bulimic women. Imipramine was associated with a significantly reduced frequency of binge eating and with improvement on several other measures of eating behavior. On 1- to 8-month follow-up, 18 of the 20 treated subjects (90%) had responded to imipramine or a subsequent antidepressant. This finding augments the growing evidence that bulimia may be related to affective disorder.
ON MARX, HEGEL, AND CRITICAL THEORY IN POSTWAR GERMANY: A CONVERSATION WITH IRING FETSCHER

This paper consists of an introduction to the life and work of Iring Fetscher by the interviewer, followed by a conversation with Fetscher, and notes. In the interview, Fetscher discusses his relationship to Marxism, Hegelianism, Lukacs, and the Frankfurt School, as well as his critique of Althusser. The contribution of Fetscher, an extremely well-known German specialist on Soviet and Marxist thought, is here discussed in greater detail than anywhere else to date in the English-language scholarly literature.
A 300 THz tabletop radar range system with sub-micron distance accuracy.

We are presenting a compact radar range system with a scale factor of 105. Replacing the radio frequency (RF) by optical wavelength (300 THz), the system easily fit on a tabletop. We used interferometric time-of-flight to reproduce radar ranging measurements. Sub-micron range accuracy was achieved with a 100 fs laser pulse, which correspond to 3 cm for a s-band (3 GHz) radar. We demonstrated the system potential on a simple target, and compared the results with radio frequency measurement using a vector network analyzer. We also present measurement with a more realistic model, a 3D printed reproduction of the USS Arizona battleship, for which a 3D model is extracted from the ranging data. Together with our previous demonstration of radar cross section measurement with a similar system, this report further validates our proposal to use optics to simulate radar properties of complex radio frequency systems.
Considering the role of early discrimination experiences and the parent–child relationship in the development of disruptive behaviors in adolescence

Discrimination has been shown to be related to diminished psychological adjustment and greater risk for substance use when personally experienced by adolescents and when their caregivers experience discrimination. Our research considers the impact of primary caregiver experiences of racial- and socioeconomic-based discrimination in early (age 3-5 years) and late childhood (age 9½) on adolescent disruptive behaviors (age 14) with a large sample of diverse caregiver-child dyads (N = 634). In addition, we examine the potential protective effects of parent-child relationship quality in early and late childhood in buffering the effects of caregiver discrimination on adolescent disruptive behaviors. We also explore possible gender differences in children's vulnerability to engage in disruptive behaviors in the context of caregiver experiences of discrimination. The findings from this study indicate that at trend level, early childhood experiences of primary caregiver discrimination (ages 3-5) predicted adolescent disruptive behaviors, accounting for the effects of more recent (age 9½) caregiver discrimination. In addition, parent-child relationship quality at age 9½ years was found to buffer the effects of late childhood (age 9½) primary caregiver discrimination on adolescent disruptive behaviors for both male and female youth. The findings highlight the need for prevention and intervention techniques that foster healthy and positive primary caregiver-child relationships.
Optimal Control Methods for Photovoltaic Enabled Grid With Abnormal Power Loads

This paper proposes two different control approaches to minimize the power loss subject to voltage constraints when photovoltaic (PV) cells are connected to the grid subject to abnormal (unexpected and extremely high) power loads. A dynamic load model is integrated with the DistFlow equations to describe the transient behavior of the real/reactive power, voltage, and loads. Based on this model, the proposed controllers utilize PV inverters to optimize performances of the grid by absorbing/injecting the reactive power. These controllers are particularly efficient to handle unexpected abnormal power loads. For demonstrations, a bidirectional, single branch distribution circuit with extremely high power load is used to test and compare our controllers with existing approaches, including the volt-ampere reactive control scheme specified by the IEEE Standard 1547 and adaptive method. The results show that our controllers indeed reduce the power loss compared with other methods and keep the voltage within the desired range.
Rees-Sciama Effect in a CDM Universe

The Rees-Sciama (RS) effect produces fluctuations in the cosmic microwave background (CMB) through the time-dependent gravitational potential in the nonlinear stages of evolution. I investigate the RS effect on the CMB angular power spectrum $C_l$ for several CDM models by combining the results of N-body simulations with second order perturbation theory. The amplitude of the RS fluctuations peaks at $l \sim 100-300$, where it gives $\Delta T /T \sim 10^{-7}-10^{-6}$ for a wide range of models. This is at least an order of magnitude below the COBE normalized primary contribution. RS fluctuations could be a dominant source of anisotropies only on subarcminute scales ($l \approx 5000$) and are below the present day observational sensitivities on all angular scales.
Personality determinants of subjective executive function in older adults.

Objectives: Problems in subjective executive function, the perceived cognitive control of mental processes for goal-directed behavior, may indicate cognitive impairment in older adulthood. Although...
Enhanced tES and tDCS computational models by meninges emulation

Objective Understanding how current reaches the brain during transcranial electrical stimulation (tES) underpins efforts to rationalize outcomes and optimize interventions. To this end, computational models of current flow relate applied dose to brain electric field. Conventional tES modeling considers distinct tissues like scalp, skull, cerebrospinal fluid (CSF), gray matter and white matter. The properties of highly conductive CSF are especially important. However, modeling the space between skull and brain as entirely CSF is not an accurate representation of anatomy. The space conventionally modeled as CSF is approximately half meninges (dura, arachnoid, and pia) with lower conductivity. However, the resolution required to describe individual meningeal layers is computationally restrictive in an MRI-derived head model. Emulating the effect of meninges through CSF conductivity modification could improve accuracy with minimal cost. Approach Models with meningeal layers were developed in a concentric sphere head model. Then, in a model with only CSF between skull and brain, CSF conductivity was optimized to emulate the effect of meningeal layers on cortical electric field for multiple electrode positions. This emulated conductivity was applied to MRI-derived models. Main results Compared to a model with conventional CSF conductivity (1.65 S m-1), emulated CSF conductivity (0.85 S m-1) produced voltage fields better correlated with intracranial recordings from epilepsy patients. Significance Conventional tES models have been validated using intracranial recording. Residual errors may nonetheless impact model utility. Because CSF is so conductive to current flow, misrepresentation of the skull-brain interface as entirely CSF is not realistic for tES modeling. Updating the conventional model with a CSF conductivity emulating the effect of the meninges enhances modeling accuracy without increasing model complexity. This allows existing modeling pipelines to be leveraged with a simple conductivity change. Using 0.85 S m-1 emulated CSF conductivity is recommended as the new standard in non-invasive brain stimulation modeling.
Tureng Tepe, a Bronze Age Centre in Northeastern Iran Revisited

Tureng Tepe is a major site in the archaeology of Iran, but despite having been excavated by two different foreign archaeological missions, crucial periods in its history remain underreported. This...
Malestar psicológico en estudiantes universitarios: una mirada desde el modelo de promoción de la salud

This article has as purpose to ana - lyze the psychological discomfort phenomenon conceptually, recognize the magnitude of this problem on college students and analyze this phenomenon from the Model of Health Promotion. Psycholog - ical discomfort is a mental health problem, although not a psychiatric disease produces a series of clini - cal expressions that alter the nor - mal performance of people, so its main features and expressions are analyzed. College students are par - ticularly vulnerable to develop this problematic group, so personal and contextual characteristics that ex - pose them to a series of stress fac - tors associated with college expe - rience are presented, which causes more than 40% manifest symptoms that can attributed to psychological discomfort. The magnitude of this situation requires that the disciplines of thearea of health provide alter - natives to address this phenomenon. From the Nursing Theory “Model Health Promotion” posed by Nola J. Pender, seems to offer interesting to address these conceptual aspects, so a proposal is presented to analyze the psychological discomfort among college students from this theoretical position.
A multi-state examination of the victims of fatal adolescent intimate partner violence, 2011-2015

Background: Fatal intimate partner violence occurs among adolescents, which is often when first exposure to intimate partner violence occurs in the United States. However, research mainly examines intimate partner violence-related fatalities between adult intimate partners. Such findings document that non-intimate partners, corollary victims, are at risk for violence during intimate partner violence incidents, as well. Research examining fatal intimate partner violence among adolescents is scant. This study informs public health of the extent and circumstances of fatal adolescent intimate partner violence by quantifying the burden across a five-year span; describing fatal victims by demographics and precipitating circumstances; and examining differences by victim type. Methods: This study used data from 17 states of the United States in the National Violent Death Reporting System to examine fatal intimate partner violence-related incidents involving at least one adolescent intimate partner (15-19 years of age) from 2011-2015. IPV-related death cases were guided by the intimate partner violence surveillance criteria prescribed by Centers for Disease Control and Prevention. Decedents were subdivided into intimate partner victims, perpetrator victims, and corollary victims. Victims were described by demographics, victim descriptors, and precipitating circumstances of death. Annual trends and descriptive statistics were calculated. Results: There were 93 intimate partner violence-related fatal incidents among adolescents with 116 decedents. A firearm was the predominant weapon. Crises, arguments, jealousy, and physical fights were common precipitating circumstances. Corollary victims represented 18% of all victims, 65% were intimate partner victims, and 17% perpetrator victims. Corollary victims were primarily linked to the suspect by other intimate partners, and friends and acquaintances. Conclusions: Intimate partner violence is a preventable public health problem. This study documents that intimate partner violence among adolescents can result in deaths of intimate partners and corollary victims. Effective prevention should begin in early adolescence and incorporate shared and protective risk factors to have the greatest impact on adolescent IPV.
Immediate and residual antifungal activity of compounds used for whole body and adjuvant topical therapy against Microsporum canis: an in vitro study

Background Topical antifungal therapy is recommended to disinfect hairs of dermatophyte-infected animals. Objective To determine the immediate and residual (24, 48 and 72 h) antifungal activity of commonly used products for focal (n = 11) and whole body application (n = 3). Animals Hair samples from naturally infected kittens. Methods and materials Immediate antifungal activity was assessed using isolated infected spores. In a more robust challenge, toothbrushes containing whole infected hairs were repeatedly treated with products until culture-negative. Residual activity was determined by treating 0.04 g of uninfected hair with test products, allowing hairs to dry and then plating hairs onto fungal culture plates inoculated with Microsporum canis. Residual activity was assessed at 24, 48 and 72 h post-treatment. Results All products showed good efficacy against isolated infected spores. Two products required three treatments to disinfect whole infected hairs (miconazole 0.2% and ketoconazole 0.15%); all other products were efficacious after one treatment. For each product residual activity at 24, 48 and 72 h was similar. For the whole body products, lime sulfur and enilconazole showed residual activity, but as expected none was detected for 2% miconazole nitrate/ 2% chlorhexidine shampoo. For focal therapy products, residual activity was detected for clotrimazole 1%, terbinafine 1%, miconazole at 0.2, 1 or 2% (with or without chlorhexidine), climbazole 0.5% with chlorhexidine gluconate, and ketoconazole 1% with chlorhexidine gluconate. A ketoconazole 0.15% with 0.15% chlorhexidine gluconate showed no residual activity. Conclusions and clinical importance Findings support twice weekly application of enilconazole and lime sulfur, and application of adjuvant focal topical therapy daily or every other day.
Who is willing to participate in research? A screening model for an anxiety and depression trial in the epilepsy clinic

Abstract Objective Anxiety and depression in epilepsy are prevalent, associated with poor outcomes, underrecognized, undertreated, and thus a key area of need for treatment research. The objective of this study was to assess factors associated with research participation among epilepsy clinic patients who screened positive for anxiety or depression. This was accomplished by characterizing clinical and psychiatric factors among patients seen in an epilepsy clinic and evaluating which factors were associated with consent for potential research participation, via a combined clinical and research screening model. Methods In a pragmatic trial of anxiety and depression treatment in epilepsy, individuals with a positive screen for anxiety and/or depression at a routine epilepsy clinic visit were invited to opt-in (via brief electronic consent) to further eligibility assessment for a randomized treatment study. Information on psychiatric symptoms and treatment characteristics were collected for dual clinical care and research screening purposes. Cross-sectional association of demographic, clinical, and psychiatric factors with opting-in to research was analyzed by multiple logistic regression. Results Among N = 199 unique adults with a first positive screen for anxiety and/or depression among 786 total screening events, 154 (77.4%) opted-in to further potential research assessment. Higher depression scores and current treatment with an antidepressant were independently associated with opting-in to research (depression odds ratio (OR) = 1.13 per 1-point increase in Neurological Disorders Depression Inventory-Epilepsy (NDDI-E) score, p = 0.028, 95% confidence interval (CI): 1.01–1.26; antidepressant OR = 2.37, p = 0.041, CI: 1.04–5.41). Nearly half of the 199 individuals (43.7%) with anxiety and/or depression symptoms were already being treated with an antidepressant, and 46.7% were receiving neither antidepressant therapy nor mental health specialty care. One-quarter (24.1%) reported a past psychiatric hospitalization, yet only half of these individuals were receiving mental health specialty care. Significance Our results demonstrate a high willingness to participate in research using a brief electronic consent approach at a routine clinic visit. Adults with persistent anxiety or depression symptoms despite antidepressant therapy and those with higher depression scores were more willing to consider a randomized treatment study. This has implications for future study design, as individuals already on treatment or those with more severe symptoms are often excluded from traditional research designs. We also found a high burden of psychiatric disease and high prevalence of persistent symptoms despite ongoing antidepressant treatment.
Developing a Hospital Quality Metrics System and Dashboard

Hospitals and health systems are responsible for reporting hundreds of distinct quality process and outcome measures to regulatory and accreditation agencies and to insurers. Organizations spend significant resources collecting and reporting a complex array of quality metrics, despite the fact that many metrics are of uncertain validity. To make sense of the proliferation of quality measures and to guide organizational performance goals, Tufts Medical Center and Floating Hospital for Children selected a subset of high-value measures to monitor and manage. The medical center’s quality leaders, with input from trustees on the board quality committee, developed a quality dashboard, dashboard summary, and “harm bubble” that captured and tracked measures that matter. We then tied the dashboard to the annual goal-setting process, using dashboard results to track the performance of key improvement initiatives. We also updated dashboard metrics to align with new goals. Presenting measures that matter in a quality dashboard was a productive way to bring coherence and focus to quality improvement and patient safety efforts.
Effective analog/mixed-signal circuit placement considering system signal flow

Placement is among the most critical steps in analog/mixed-signal (AMS) circuit layout synthesis. It implicitly determines the wiring topology and therefore has considerable impacts on post-layout parasitics and coupling. Existing analog placement techniques are mainly focusing on geometric constraints in analog building blocks. However, there yet lacks an effective way to consider the system-level signal flow for sensitive AMS circuits. Leveraging prior knowledge from schematics, we propose to consider the critical signal paths in automatic AMS placement and present an efficient framework. Experimental results demonstrate our proposed framework's efficiency and effectiveness with a 22.8% reduction in routed wire-length compared to state-of-the-art AMS placer and 10 dB improvement in the signal-to-noise-and-distortion ratio (SNDR) for an ADC.
Gender, Generations, and Non-Farm Participation

This paper presents an empirical analysis of intergenerational linkages in non-farm participation with a focus on gender effects. The evidence, using survey data from Nepal, shows that the mother exerts strong influence on a daughter's employment choice: having a mother in non-farm sector raises a daughter's probability of non-farm participation by 200 percent. The effects are truly dramatic for skilled non-farm jobs; having a mother in skilled job raises daughter's probability by 1200 percent. Having a father in non-farm, on the other hand, does not have any significant effect on a son's probability of non-farm participation when the endogeneity of education and assets is corrected for by Two Stage Conditional Maximum Likelihood approach. However, a moderate positive intergenerational correlation between fathers and sons exists for skilled jobs.
Finding Video-watching Behavior Patterns in a Flipped CS1 Course

Flipped courses often rely on pre-recorded videos that students are expected to watch before in-class time with the instructor. In this study, we investigated the video-watching behavior of students in a flipped CS1 programming course (n=490). We computed three behavioral metrics related to video watching: percentage of the videos watched, the number of times a video was opened to be watched, and when a video is watched with respect to the due date. We used k-medoids clustering on these metrics finding two distinct groups: 1) Low Video Engagement Group (53% of the students) watched 12% of the videos and 2) High Video Engagement Group (47% of the students) watched 75% of the videos. Analysis of these two different groups of engagement showed that students with prior programming experience watch fewer videos. We also found that students that watch more videos perform slightly better on summative assessments in the course. We discuss how regular video watching can be a key learning strategy for some but not all students in a flipped CS1 course, where some students can achieve good learning outcomes with minimal watching of the course videos.
Unequally Safe: Association Between Bullying and Perceived School Safety and the Moderating Effects of Race/Ethnicity, Gender, and Grade Level

Guided by the social–ecological, social identity, and social misfit theories, the present study examined the gender, racial/ethnic, and grade-level differences of students’ perceived school safety ...
A 5-Minute Cognitive Assessment for Safe Remote Use in Patients With COVID-19: Clinical Case Series.

Background: Early clinical experience during the COVID-19 pandemic has begun to elucidate that the disease can cause brain function changes that may result in compromised cognition both acutely and during variable recovery periods. Reports on cognitive assessment of patients with COVID-19 are often limited to orientation alone. Further assessment may seem to create an inappropriate burden for patients with acute COVID-19, which is characterized by fatigue and confusion, and may also compromise examiner safety. Objective: The aims of this study were to assess cognition in patients with COVID-19 as comprehensively as possible in a brief format, while observing safety precautions, and to establish a clear face value of the external validity of the assessment. Methods: We adapted a brief cognitive assessment, previously applied to liver transplant candidates and medical/surgical inpatients, for remote use in patients hospitalized for COVID-19 treatment. Collecting quality assurance data from telephone-administered assessments, this report presents a series of 6 COVID-19 case vignettes to illustrate the use of this 5-minute assessment in the diagnosis and treatment of brain effects. Primary medical teams referred the cases for neuropsychiatric consultation. Results: The age of the patients varied over four decades, and none of them were able to engage meaningfully with their surroundings on admission. On follow-up examination 6 to 10 days later, 4 of the 6 patients had recovered working memory, and only 1 had recovered calculation ability. Of the 6 patients, 2 were capable of complex judgment responses, while none of the cases completed frontal executive function testing in the normal range. Conclusions: Cognitive assessment in patients with COVID-19 using this remote examination reveals patterns of cognitive recovery that vary among cases and are far more complex than loss of orientation. In this series, testing of specific temporal, parietal, and frontal lobe functions suggests that calculation ability, judgment, and especially frontal executive functions may characterize the effects of COVID-19 on the brain. Used widely and serially, this examination method can potentially inform our understanding of the effects of COVID-19 on the brain and of healing from the virus.
Charting a shared epigenetic pathway to CD8+ T cell dysfunction in infection and cancer.

Pritykin et al. (2021) establish a comprehensive chromatin atlas of CD8+ T cell dysfunction in chronic viral infection and cancer via analysis of bulk and single-cell ATAC-seq datasets across immune challenges. These results unify the classification scheme and molecular programs driving CD8+ T cell dysfunction across disease settings and will facilitate basic discovery and translational efforts in T cell immunity.
“Sainte! Libre! Souveraine!:” Jean-Luc Raharimanana’s Ecocidal Writing of the Land in Nour, 1947

In Nour, 1947, Jean-Luc Raharimanana recounts the 1947 Malagasy Uprising, when France killed 89,000 Malagasy combatants and civils to repress their struggle for independence and political sovereign...
Maternal Diabetes and Neonatal Macrosomia I. Postpartum Maternal Hemoglobin A1c Levels and Neonatal Hypoglycemia

Hemoglobin A1c (HgbA1c) levels were determined within 24 hours after delivery in 88 nondiabetic and 73 diabetic women belonging to White's classes A to D. Diet-controlled gestational diabetic women had mean (+/- SE) Hgb A1c levels similar to those of nondiabetics (5.8 +/- 0.18% vs 5.7 +/- 0.08%). Mean Hgb A1c levels were higher in insulin-requiring gestational (6.4 +/- 0.20%, P less than .05) and permanent (6.5 +/- 0.27%, P less than .05) diabetics than in nondiabetics. The proportions of subjects with levels above the normal range were also larger in the insulin-requiring groups. Mean Hgb A1c levels and the proportions of abnormally high levels were similar for mothers of macrosomic and of normally grown neonates in the nondiabetic as well as in the various diabetes groups. There was no correlation between maternal Hgb A1c level and neonatal birth weight, either real or relative. There were also no statistically significant differences in mean Hgb A1c levels between mothers of neonates with or without hypoglycemia within four hours of birth. Hgb A1c measurement did not permit differentiation between those mothers of macrosomic neonates who were diabetic and those who were not. In conclusion, although Hgb A1c level has been shown to reflect diabetic control, our data suggest that it may not be reliable as an indicator of fine tuning during the third trimester of pregnancy or as a predictor of the effects of diabetes on the fetus.