cssi/SciSciGPT-SciSciNet huggingface dataset:
A Perturbative Inverse Method for the Determination of Geoacoustic Parameters in Shallow Water

An inverse method is described for obtaining the acoustic properties of a horizontally stratified bottom in shallow water from measurements of the magnitude and phase versus range of the pressure field due to a CW point source. These data are numerically Hankel transformed to obtain the depth-dependent Green’s function versus horizontal wavenumber. The Green’s function contains prominent peaks at horizontal wavenumbers corresponding to the eigenvalues for any trapped and virtual modes excited in the waveguide. The eigenvalues are then used as input data to a perturbative inverse scheme. The method is applied to the problem of determining the compressional wave speed as a function of depth and is demonstrated for experimental data. The results are compared with those obtained using an iteration of forward models method.
A method to switch from oral dopamine agonists to rotigotine in patients with restless legs syndrome and mild augmentation

Abstract Background We examined the short- and long-term efficacy and tolerability of a cross-titration algorithm from oral dopamine agonists to the rotigotine transdermal patch in patients dissatisfied with their restless legs syndrome (RLS) treatment, predominantly with mild augmentation. Methods Patients with RLS ( n = 20) were recruited at a single site. The cross-titration consisted of decreasing oral dopaminergic agents (ropinirole by 1 mg or pramipexole by 0.25 mg) and increasing rotigotine by 1 mg every two days. Efficacy and adverse events (AEs) were assessed at one, three, six and 12 months after the switch. Results Patients had moderate–severe RLS symptoms at the baseline (mean international restless legs syndrome (IRLS) score 19.4 ± 5.5); 85% had augmentation and 45% reported afternoon RLS symptoms. The baseline mean pramipexole equivalent dose was 0.6 ± 0.3 mg. At Week 5, 85% (17/20) had successfully switched from their oral dopamine agonist to rotigotine (mean dose 2.5 ± 0.6 mg; change in IRLS score: −6.7 ± 8.4, p = 0.002); 14 patients were CGI-I responders (much or very much improved). Three patients withdrew due to lack of efficacy. Twelve months after cross-titration, 10 patients continued on rotigotine, of whom four required either higher doses of rotigotine or supplemental RLS medication compared with their optimal Week 5 dose; five patients withdrew due to AEs and two due to lack of efficacy. Conclusion A cross-titration to rotigotine was efficacious after five weeks in 70% of patients dissatisfied with RLS treatment, most of whom had mild augmentation. At one year following the medication switch, 50% had discontinued rotigotine due to lack of continued efficacy or side effects.
Modular structure of the development

The Verified Software Toolchain has many components, put together in a modular way: msl . The proof theory and semantics of separation logics and indirection theory is independent of any particular programming language, independent of the memory model, independent of particular theories of concurrency. compcert . The CompCert verified C compiler is independent of any particular program logic (such as separation logic), of any particular theory of concurrency, and of the external-function context (such as an operating system-call setup). CompCert incorporates several programming languages, from C through C light to C minor and then (in various stages) to assembly languages for various target machines. The CompCert family may also include source languages such as C++ or ML. These various operational semantics all use the same memory model, and the same notion of external function call. sepcomp . The theory of separate compilation explains how to specify the compilation of a programming language that may make shared-memory external function calls, shared-memory calls to an operating system, and shared-memory interaction with other threads. This depends on CompCert's memory model, but not on any particular one of the CompCert languages. Eventually, parts of the sepcomp theory will migrate into CompCert itself. Some parts of the separate-compilation system concern modular program verifications of modular programs. We may even want to link program modules—and their verifications—written in different languages (C, ML, Java, assembly). This system requires that each language have a program logic that uses the same mpred (memory predicates) modeled using resource maps (rmap).
Abstract 3005: The impact of mitochondrially targeted oncology agents on mitochondrial DNA (mtDNA) integrity

Reactive oxygen species (ROS) are natural byproducts of mitochondrial oxidative phosphorylation. Dysfunction in electron shuttling leads to enhanced ROS production that is notorious for inflicting damage to macromolecules. Mitochondrial DNA (mtDNA) is particularly sensitive to ROS as it is located in close proximity to the respiratory chain. Additionally, mtDNA lack histones which are known to provide protection from ROS. Mitochondria also have limited DNA repair mechanisms making damage to mtDNA more detrimental to mitochondrial physiology. Recent evidence suggests that oxidative insult, leads to mtDNA degradation to prevent the accumulation of mutagenic base lesions, which is enabled by the high redundancy of mtDNA. The primary objectives of this study were to determine the impact of redox-active mitochondrial-targeted chemotherapeutic agents on mitochondrial physiology and mtDNA integrity. All experiments were performed in two cancer cell lines [MDA-MB-231 (breast) and H23 (lung)] that were treated with 2 uM of the mitochondrial-targeted redox-active compounds: MitoTempol [C4 (MT4)], MitoQuinone (MQ) and MitoChromanol-Acetate (MCA) for 1 or 24 hrs. Mitochondrial status was determined by measuring mitochondrial membrane potential, superoxide production, oxygen consumption rate (OCR) and protein levels of the respiratory chain complexes using the JC-1 and MitoSOX assays, Seahorse XF analysis, and immunoblotting, respectively. Next, mtDNA integrity was analyzed by quantifying the degree of mtDNA fragmentation using PCR amplification of a 10kb fragment compared to a short 100bp fragment. Moreover, changes in the mtDNA replication machinery were assessed using immunoblotting. MQ and MCA induced a loss in mitochondrial function and mtDNA replication machinery as indicated by a reduction in membrane potential, OCR and protein levels. Furthermore, increases in superoxide levels and mtDNA fragmentation were observed with MQ and MCA treatment. Finally, we assessed mitochondrial content using two methods. The first method being the ratio of mitochondrial to nuclear DNA, determined by qPCR of short (∼100bp) nuclear and mitochondrial sequences. The second method was the ratio of mitochondrial outer membrane proteins to cytoplasmic housekeeping proteins, determined by immunoblotting. Both mitochondria DNA and outer membrane proteins decreased with MQ and MCA treatment suggesting that redox-active mitochondrial-targeted agents may reduce the mitochondrial content in cancer cells. Citation Format: Kaytee L. Pokrzywinski, Thomas G. Biel, Dmitry Kryndushkin, V. Ashutosh Rao. The impact of mitochondrially targeted oncology agents on mitochondrial DNA (mtDNA) integrity. [abstract]. In: Proceedings of the 107th Annual Meeting of the American Association for Cancer Research; 2016 Apr 16-20; New Orleans, LA. Philadelphia (PA): AACR; Cancer Res 2016;76(14 Suppl):Abstract nr 3005.
A Solar-Pumped Fluorescence Model for Line-By-Line Emission Intensities in the B-X, A-X, and X-X Band Systems of 12C14N

We present a new quantitative model for detailed solar-pumped fluorescent emission of the main isotopologue of CN. The derived fluorescence efficiencies permit estimation and interpretation of ro-vibrational infrared line intensities of CN in exospheres exposed to solar (or stellar) radiation. Our g-factors are applicable to astronomical observations of CN extending from infrared to optical wavelengths, and we compare them with previous calculations in the literature. The new model enables extraction of rotational temperature, column abundance, and production rate from astronomical observations of CN in the inner coma of comets. Our model accounts for excitation and de-excitation of rotational levels in the ground vibrational state by collisions, solar excitation to the A(sup 2)Pi(sub I) and B(sup 2)Sum(sup +) electronically excited states followed by cascade to ro-vibrational levels of X(sup 2)Sum(sup +), and direct solar infrared pumping of ro-vibrational levels in the X(sup 2)Sum(sup +) state. The model uses advanced solar spectra acquired at high spectral resolution at the relevant infrared and optical wavelengths and considers the heliocentric radial velocity of the comet (the Swings effect) when assessing the exciting solar flux for a given transition. We present model predictions for the variation of fluorescence rates with rotational temperature and heliocentric radial velocity. Furthermore, we test our fluorescence model by comparing predicted and measured line-by-line intensities for X(sup 2)Sum(sup +) (1-0) in comet C/2014 Q2 (Lovejoy), thereby identifying multiple emission lines observed at IR wavelengths.
The Paleo-Indian and Archaic Occupation of the Tucson Basin: An Overview

Evidence for the occupation of the Tucson Basin during the Paleo-Indian and Archaic periods is presented and assessed. There is at present no conclusive evidence for Paleo-Indian utilization of the...
Designing a Course Integrating Critical Pedagogy, Fantasy Literature, and Religious Studies

This chapter is intended as an aid for designing either a full course on the intersection of critical pedagogy, fantasy literature, and religious studies or at least material for one or two lessons along these lines in a course in religious studies or English, based on the conviction that teachers of both literature and religion may benefit from each other’s critical insights and material. Furthermore, this chapter’s proposals will hopefully be flexible enough to aid course development for high school, undergraduate, or graduate levels.
Frigid Embrace: Politics, Economics, and Environment in Alaska

Frigid Embrace explores how the drive to extract natural resources has shaped Alaskans' understanding of the environment and their relationships with the region's Native peoples. This insightful account of Alaska's colonial struggles offers readers a key to understanding the roots of current environmental controversies.
Equity Breakeven Point: A Graphical and Tabulation Tool for Engineering Managers

AbstractThis article presents a graphical and tabulation framework for the application of equity breakeven point (EBP) for financial management of engineering projects. EBP was previously developed as a computational tool for the analysis of mortgage payments. This article presents a user-friendly framework for visualizing and assessing the utility of EPB in engineering projects. The proposed graphical and tabulation framework extends the application of EPB to general capital investments, which are part of engineering projects. Engineering managers and other practitioners can utilize the tabulation of EBP to assess what-if options in major financial transactions. The mathematical derivation of the EPB indicates the time when the unpaid balance on a capital investment is equal to the cumulative equity in the investment, thereby providing a-priori insight into how long it might take to retire an investment loan on the strength of the accrued equity. This type of graphical visualization is useful for negotia...
Pixel-wise structural motion tracking from rectified repurposed videos

Summary After any disaster, there is an immediate need to assess the integrity of local structures. When available, the displacement time history of a structure during the event can provide an invaluable source of triage assessment information. Although conventional sensors such as accelerometers readily provide this information, many structures are not instrumented and in these cases an alternative is needed. This paper presents such an alternative: a flexible, low-cost, and target-free approach to extracting motion time histories from video recordings of structures during an event. The approach is designed for scenarios where video recordings have inadvertently captured a dynamic event, with the goal of repurposing them for structural triage assessment through a combination of computer vision and signal processing techniques. A combination of parametric video stabilization, 3D denoising, and outlier robust camera motion estimation are employed to mitigate of the effects of camera motion and video encoding artifacts. The approach leverages the computer vision concept of optical flow to provide motion estimates, and 4 canonical optical flow algorithms are assessed as part of this study. The developed approach was validated on the records of the Network for Earthquake Simulation database. The overall findings indicate that the developed method is effective at reconstructing dynamic structural time histories, though the choice of optical flow algorithm plays a significant role in the overall performance. In particular, any employed optical flow algorithm must not overpenalize the high motion gradients that occur at the boundary of in-motion buildings and the image background.
What are the complications and emerging strategies for preventing depression following traumatic brain injury

Depression is a common and disabling complication of traumatic brain injury (TBI). The high rates of post-TBI depression (PTBID) make this condition an important candidate for selective preventive interventions. Areas covered: The authors recently reported on the efficacy of sertraline, a selective serotonin reuptake inhibitor (SSRI), for the prevention of new cases of depression in the first six months after TBI. The authors review this and other studies on preventive strategies in PTBID as ascertained from a PubMed and citation search. The potential complications and barriers to the implementation of pharmacological prevention in patients with TBI are also discussed. Expert commentary: The prevention of depression in patients with TBI has received little attention relative to other medical conditions. Future studies are needed to confirm the benefit of SSRIs and investigate other pharmacological and non-pharmacological interventions, including in special groups of patients at greater risk of developing PTBID.
Smoking history and frequency of somatic KRAS mutations in adenocarcinoma of the lung

7573 Background: Somatic mutations in the epidermal growth factor receptor (EGFR) gene are more common in patients with adenocarcinoma, especially those who smoked < 15 pack years (py). KRAS mutations are found in ∼25% of lung adenocarcinomas, most commonly in codons 12 and 13 of exon 2 (∼85%) and have been associated with poor prognosis in resected disease [Winton NEJM 2005] and resistance to EGFR tyrosine kinase inhibitors [Pao PLoS Med 2005]. KRAS mutations are uncommon in non-small cell lung cancer histologies other than adenocarcinoma. We sought to determine the association between quantitative measures of cigarette smoking and presence of KRAS mutations in lung adenocarcinomas. Methods: Standard direct sequencing techniques were used to identify KRAS codon 12 and 13 mutations in lung adenocarcinoma specimens from surgical resections between 2001 and 2006 and tumor specimens sent for KRAS molecular analysis in 2006. Surgical specimens were obtained from an institutional tumor bank. Detailed smoking h...
The Keats Letters Project

The Keats Letters Project was conceived as an ongoing bicentennial celebration of John Keats’s correspondence. On the 200th anniversary of the original composition of each of the letters we recircu...
The Theory and Practice of Strategic Management in Smaller Rapid Growth Firms

This article contrasts the theory of strategic planning with actual practice in smaller rapid growth companies. The literature on strategic planning in general and smaller organizations in particul...
An overview of the Japanese quotative itta and itte ita

The present study provides an overview of the quotative utterances made with itta (past form of iu ‘to say’) and itte ita (the combination of iu and the past form of the -te iru construction) in naturally occurring conversations in Japanese. The examination of approximately 13 hours of conversations shows that itta is used in 91.1% of first-person quotations (‘I said that…’). In second-person (‘you said that…’) and third-person (‘he/she said that…’) quotations, itte ita is used in 90.0%, and 77.3% of the cases, respectively. The present study argues that the high percentage of itte ita for second- and third-person quotative utterances is due to the fact that the - te iru construction, which is included in itte ita , is used as an evidential marker. The present study also analyzes the deviant cases from the dominant pattern (i.e. using itta for third-person utterances), and demonstrates how - te iru ’s evidential function is utilized manipulatively in conversation.
Context Sensitive Gestures

Touchscreens and stylus input are becoming increasingly popular in modern computers. However, many programs still require keyboard input in order to take full advantage of their functionality. In order to increase the functionality of screen-based input, gestures are being adopted to input commands. However, current gesture interfaces are not sufficiently context-based, which limits their usefulness to a few applications, and they are not dynamic or interactive, which wastes time and keeps the user from feeling comfortable using them. In order to improve gesture functionality, we used off-the-shelf hardware and implemented a gesture-based system which changed gesture function based on currently running application, and based on recent gesture activity. The result of application-sensitivity was a system which is useable on many modern computers and provides useful functionality in a variety of applications. The results of sensitivity to previous gestures, however, was only minimal interactivity.
A greedy memetic algorithm for a multiobjective dynamic bin packing problem for storing cooling objects

In this paper, a multiobjective dynamic bin packing problem for storing cooling objects is introduced along with a metaheuristic designed to work well in mixed-variable environments. The dynamic bin packing problem is based on cookie production at a bakery, where cookies arrive in batches at a cooling rack with limited capacity and are packed into boxes with three competing goals. The first is to minimize the number of boxes used. The second objective is to minimize the average initial heat of each box, and the third is to minimize the maximum time until the boxes can be moved to the storefront. The metaheuristic developed here incorporated greedy heuristics into an adaptive evolutionary framework with partial decomposition into clusters of solutions for the crossover operator. The new metaheuristic was applied to a variety benchmark bin packing problems and to a small and large version of the dynamic bin packing problem. It performed as well as other metaheuristics in the benchmark problems and produced more diverse solutions in the dynamic problems. It performed better overall in the small dynamic problem, but its performance could not be proven to be better or worse in the large dynamic problem.
The Zonation and Structuring of Siliceous Sinter around Hot Springs, Yellowstone National Park, and the Role of Thermophilic Bacteria in Its Deposition

Studies of early terrestrial life have shown that before about 2 billion years ago (Ga) the Earth’s biota was dominated by prokaryotic bacteria, possibly including photosynthetic cyanobacteria. As a geologic record, these early organisms have left carbonaceous microfossils, inferred to be the remains of individual filamentous and coccoidal bacteria, and flat, domal, and columnar laminated structures called stromatolites, which are interpreted to have formed through the vertical accretion of bacterial mat communities (Walter, 1976a). Stromatolites are abundant in thick Precambrian carbonate formations that range in age from about 3.0 Ga to the end of the Precambrian, about 560–530 million years ago (Ma). Precambrian carbonaceous microfossils are best preserved in siliceous rocks, called cherts, that are composed largely of microcrystalline quartz. The organisms preserved in cherts were entombed through silicification before they could be destroyed by biological degradation or chemical attack. Cherts and related siliceous deposits are widely preserved in thick sedimentary and volcanic sequences that accumulated in the Archaean (>2.5 Ga) and Proterozoic (2.5-0.53 Ga) oceans.
Bottom-up single-molecule strategy for understanding subunit function of tetrameric β-galactosidase.

In this paper, we report an example of the engineered expression of tetrameric β-galactosidase (β-gal) containing varying numbers of active monomers. Specifically, by combining wild-type and single-nucleotide polymorphism plasmids at varying ratios, tetrameric β-gal was expressed in vitro with one to four active monomers. The kinetics of individual enzyme molecules revealed four distinct populations, corresponding to the number of active monomers in the enzyme. Using single-molecule-level enzyme kinetics, we were able to measure an accurate in vitro mistranslation frequency (5.8 × 10 −4 per base). In addition, we studied the kinetics of the mistranslated β-gal at the single-molecule level.
Does nonmetastatic inflammatory breast cancer have a worse prognosis than other nonmetastatic T4 cancers

Background Both patients with inflammatory breast cancer (IFLBC) and patients with noninflammatory T4 breast cancer (non-IFLBC) have a heavy disease burden in the breast; whether the unique biology of IFLBC conveys a higher locoregional recurrence (LRR) risk and worse outcomes in comparison with other T4 lesions is uncertain. Here the outcomes of patients with IFLBC and patients with non-IFLBC treated with modern multimodality therapy are compared. Methods Patients with nonmetastatic T4 breast cancer treated with neoadjuvant chemotherapy, mastectomy, and radiation therapy between 2006 and 2016 were identified. Recurrences and survival were compared between patients with IFLBC and patients with non-IFLBC overall and stratified by receptor subtype. Results For 199 T4 patients, the median age was 52 years, and the median clinical tumor size was 7 cm. One hundred seventeen (59%) had IFLBC. With a median follow-up of 41 months, 4 patients had isolated LRR; all cases occurred in patients with IFLBC. The 5-year isolated LRR rate for patients with IFLBC was 4.8%. Overall, 14 patients had both LRR and distant recurrence (DR); 47 had DR only. The 5-year distant recurrence-free survival (DRFS) rates were similar for patients with IFLBC and patients with non-IFLBC (63% vs 71%; log-rank P = .14). The 5-year DRFS rate was lowest among triple-negative (TN) patients (43%) and was significantly lower for patients with TN IFLBC versus patients with non-IFLBC (28% vs 62%; log-rank P = .02). The 5-year overall survival rates (71% vs 74%; log-rank P = .4) and cancer-specific survival rates (74% vs 79%; log-rank P = .23) did not differ between IFLBC and non-IFLBC. Conclusions Although IFLBC is often considered a unique biologic subtype, patients with IFLBC and patients with non-IFLBC had similar outcomes with modern multimodality therapy; isolated LRR was uncommon. The TN subtype in patients with IFLBC is associated with poor outcomes, and this indicates the need for new treatment approaches in this group.
Visualizing Certainty: What the Cultural History of the Gantt Chart Teaches Technical and Professional Communicators about Management

Using a cultural-historical genre analysis of the Gantt chart, the author describes how, when a project’s progress and scope are being considered, this popular project management visualization evok...
Class II correction in orthodontic patients utilizing the Mandibular Anterior Repositioning Appliance (MARA).

ABSTRACT Objectives: To evaluate skeletal and dentoalveolar changes produced by the Mandibular Anterior Repostioning Appliance (MARA) in the treatment of Class II malocclusion in adolescent patient...
Electrochemical and Photoelectrochemical Transformations of Aqueous CO 2

This chapter covers the electrochemical and photoelectrochemical conversion of CO2 in aqueous media. It is divided into sections that consider heterogeneous electrocatalysts on metal electrodes, homogeneous catalysts interacting with metal surfaces, light-driven semiconductor electrodes, and hybrid systems that combine heterogeneous interfaces with surface-confined molecular components.
A Plug and Play Power Electronics Education Board for Hands-on Learning of Power Converters Incorporating WBG Semiconductor

This paper presents the development of a plug-and-play (PP from switching characteristic analysis of different semiconductor devices to control of different power converters such as basic DC-DC and DC-AC converters and isolation-type DC-DC converters. This helps students to get familiar with the system/subsystem-level design of power converters and experience the impact of WBG devices compared to Si-based one. The system design considerations are discussed, and the fabricated hardware and its experiments are presented.
Preliminary Results of a Phase II Study of HCVIDDoxil Alternated with Methotrexate-Cytarabine in Patients with Newly Diagnosed T-Cell Lymphoma.

Background The prognosis of patients with T-cell lymphoma (TCL) remains poor with conventional chemotherapy regimens and innovative approaches are needed. We evaluated the efficacy and safety of the regimen HCVIDDoxil, with pegylated doxorubicin substituting doxorubicin in the HCVAD regimen, alternated with MTX-Ara-C in patients with newly diagnosed TCL. Methods Previously untreated patients (pts) with Zubrod performance status 3 or less, age > 18 years, and adequate marrow, cardiac, liver and renal function were included in this study. Patients with ALK + anaplastic large cell lymphoma (ALCL), skin involvement alone, HIV positive serology, and evidence of CNS involvement were excluded. Patients received HCVIDDoxil (iv cyclophosphamide 300 mg/m 2 iv Q 12 h X 6 doses days 1–3, mesna 600 mg/m 2 iv daily over 24 hours by continuous infusion days 1–3, doxil 25 mg/m 2 /day iv on day 2, vincristine 1.4 mg/m 2 (max. 2 mg) iv days 4 and 11, dexamethasone 40 mg iv or po daily X 4 days 1–4 and 11–14) alternated with MTX/Ara-C (MTX 200 mg/m2 iv over 2 hours on day 1, then 800 mg/m 2 iv over 22 hours on day 1, Ara-C 3 g/m 2 iv Q 12 hours X 4 doses on days 3–4). Courses were repeated every 3 weeks for a maximum of 8 cycles. Endpoints were response rate and progression-free survival. Results Between October 2003 and July 2007, 38 patients (pts) were included, 20 pts with PTCL, 6 pts with ALCL-ALK-, 4 pts with NK-TCL, 4 pts with HSL, and 4 pts with AIL. Median age was 54 (range, 23–70). Thirty-three (86%) pts had stage III/IV, 5 stage I/ II. Twenty-five (65%) pts had extranodal disease, and 14 (36%) pts had bone marrow involvement. A median of 5 cycles were delivered. To date 32 pts are evaluable for response. The ORR was 87%, with CR in 19 pts (59%) and PR in 9 pts (28%). Common Grade ¾ adverse events were thrombocytopenia in 31 pts (96%), neutropenia in 24 (75%), anemia in 23 (71%), and febrile neutropenia in 7 (32%). Six of the complete responders progressed (31%, median TTP 188 days), and 13 of the responses are ongoing (+6-+36 months). Conclusions In this high-risk population the regimen HCVIDDoxil alternated with MTX-Ara-C induced a high response rate. Further follow-up is needed to evaluate if the high response rate results in improved disease-free survival. As expected, the major toxicity was myelosuppression. Enrollment in this study continues.
Inhibition of JAK1 sensitizes human head and neck cancer cells to cetuximab

Abstract Background Cetuximab (an inhibitor of EGFR) is commonly utilized for the treatment of head and neck cancers. It has been employed in combination with radiation or multi-agent chemotherapy for locoregionally advanced and metastatic head and neck cancer respectively. This study explored the use of cetuximab plus an JAK1 inhibitor (JAK1i), which is a protein that is downstream in EGFR signaling, in order to test whether this dual inhibition could accentuate the effects of cetuximab. Methods Human head and neck squamous cell cancer cells (UM-SCC-6 cells) were cultured as previously described (Bonner JA et al., BMC Cancer 15:673). The JAK1 inhibitor (JAK1i) was obtained from Calbiochem, LaJolla, CA. Standard assays of immunoblots, proliferation, apoptosis and comet assays were utilized (Bonner JA et al., BMC Cancer 15:673). Results The combination of cetuximab (0.5 μg/ml) and JAK1i (1µM) resulted in greater inhibition of STAT-3 than either agent alone on immunoblot analysis. Likewise, the combination treatment resulted in greater inhibition of cell proliferation (at 72 hours), greater apoptosis and enhanced DNA double strand breaks (comet) compared to either agent given alone. Conclusions Cetuximab initially showed activity in head and neck cancer over 20 years ago. It is currently used in combination with radiation or chemotherapy for these patients. The results reported herein suggest that the anti-proliferative effects of cetuximab can be enhanced with the addition of JAK1 inhibition. Further work exploring the targeting of various steps in EGFR signaling is warranted in head and neck cancer. Legal entity responsible for the study James A. Bonner. Funding Has not received any funding. Disclosure J.A. Bonner: Honoraria (institution), Advisory / Consultancy: Bristol-Myers Squibb Company; Honoraria (institution), Advisory / Consultancy: Eli Lily and Company; Honoraria (institution), Advisory / Consultancy: Merck Serono; Honoraria (institution), Advisory / Consultancy: Cel-Sci. E. Yang: Advisory / Consultancy, Research grant / Funding (institution): AstraZeneca; Research grant / Funding (institution): Eli Lilly. All other authors have declared no conflicts of interest.
Experimental and finite element modelling evaluation of cement integrity under diametric compression

Abstract With the increased exploration activity in unconventional and extreme operational environment, well integrity is becoming a challenging problem. Cement sheath, being an important barrier element, should be designed properly for adaptation of complicated loads surrounding the wellbores. This experimental and modelling study evaluates casing-cement-formation system under diametrically compressive load. Digital image correlation (DIC) technique was employed to examine the strain distribution and failure in experimental setup. A 3D numerical model was developed and the comparison between simulation and experimental results indicated a reasonable match. Using validated model, the effect of cement elastic properties on stresses in cement was studied. The stress distribution in the cement-formation system shows that casing-cement interface is the weakest point in the system, thus it has the highest risk of failure. The failure initiates at orientation parallel (θ = 0°) to the applied load followed by in perpendicular (θ = 90°) direction. Hoop stress is more sensitive to Young's modulus and Poisson's ratio than radial stress, so it is more critical for the failure assessment. In general, flexible cement with low Young's modulus and high Poisson's ratio has low risk of failure.
Barbed voices: oral history, resistance, and the World War II Japanese American social disaster

Barbed Voices is a very engaging collection of Arthur Hansen’s previously published work that focuses on the incarceration of Japanese Americans during World War II. The chapters are meticulously d...
Abstract IA03: PARP inhibitor and platinum resistance in ovarian cancer-genome wide CRISPR screens

High-grade serous ovarian carcinoma (HGSOC) patients with germline mutations in BRCA1/2 exhibit high sensitivity and improved outcome to platinum-based drugs and PARP inhibitors. Three PARP inhibitors (olaparib, rucaparib, niraparib) have recently gained FDA approval for the treatment of HGSOCs. However, de novo and acquired resistance to these agents is common even in the BRCA mutation carriers and pose a significant, unsolved clinical challenge. Here we identify multiple gene complexes involved in PARPi resistance through a loss-of-function CRISPR screen. High-confidence hits include previously identified 53BP1, PARP1, shieldin complex, and ATMIN/DYNLL1 complex. Only for DYNLL1 does low expression correlate with worse outcome in BRCA1-mutant ovarian cancer patients; incidentally, all these patients had platinum-based therapy. In BRCA1-defective HGSOC patients, DNA end resection is greatly compromised and contributes to the loss of HR and PARP inhibitor sensitivity. DNA end resection is a vital process that initiates homologous recombination (HR)-mediated repair of double-stranded DNA breaks and consequently influences genome stability. Loss of DYNLL1 allows DNA end resection and restores HR in BRCA1-mutant cells, thereby inducing resistance to platinum drugs and PARP inhibitors. In primary ovarian carcinomas low BRCA1 expression correlates with increased chromosomal aberrations, and the junction sequences of somatic structural variants indicate the loss of HR. Concurrent decrease in DYNLL1 expression in BRCA1-low ovarian cancers “rescued” this phenotype with reduced genomic alterations and increased homology at putative lesions. From the mechanistic standpoint, we observed that DYNLL1 limits nucleolytic degradation of DNA ends by interacting with the DNA end resection machinery (MRN complex, BLM helicase, and DNA2) in cells. The impact of DYNLL1 on end resection can be recapitulated in vitro; this is dependent on direct interaction with MRE11. Furthermore, DYNLL1 mutants that do not interact with MRE11 phenocopy the PARPi resistance phenotype of DYNLL1/BRCA1-deficient cells. Therefore, we infer that DYNLL1 is an important antiresection factor that significantly influences genomic stability and response to DNA-damaging chemotherapy in ovarian cancer patients. Citation Format: Dipanjan Chowdhury. PARP inhibitor and platinum resistance in ovarian cancer-genome wide CRISPR screens [abstract]. In: Proceedings of the AACR Special Conference on Advances in Ovarian Cancer Research; 2019 Sep 13-16, 2019; Atlanta, GA. Philadelphia (PA): AACR; Clin Cancer Res 2020;26(13_Suppl):Abstract nr IA03.
The cruel optimism of “good crunch”: How game industry discourses perpetuate unsustainable labor practices:

The video game industry’s labor practices have become an increasingly common topic of discussion throughout game studies and the gaming community, especially when it comes to “crunch” or periods of...
Bidirectional Intimate Partner Violence: Evidence from a List Experiment in Kenya

Intimate Partner Violence (IPV) responds to economic policies and affects economic outcomes. Two common misconceptions are that IPV is predominantly unidirectional, and that physical violence perpetrated by women against men is marginal. We conduct the first list experiment with married couples to identify the incidence of physical violence on both men and women. We find that 14 percent of respondents agree with the statement "my spouse regularly hits me.'' In contrast to survey evidence, we find no differences in the incidence of male-to-female and female-to-male violence. We provide supporting evidence that bidirectional IPV accounts for the lack of gender differences.
Quantum Algorithm for Time-Dependent Hamiltonian Simulation by Permutation Expansion

An integral-free approach is introduced for time-dependent Hamiltonian simulation that leads to algorithmic speedup for many relevant systems.
The heart in uterine myoma

Abstract The present study was undertaken to determine, if possible, whether uterine fibroids produced any definite and demonstrable effect upon the cardiovascular system.
Non-histone proteins. The effect of nuclear washes and comparison of metaphase and interphase chromatin.

Abstract SDS Gel electrophoresis of mouse nuclei washed with various salt solutions and of Chinese hamster metaphase and interphase chromatin led to the following conclusions. 1. 1. The pattern of non-histone proteins was the same after nuclei were washed with solutions varying markedly in ionic strength and cation content. 2. 2. The pattern of the nuclear sap and the non-histone proteins showed many similar bands suggesting they are not totally distinct entities. The nuclear sap appears to be composed of several classes of proteins varying in their affinity for DNA. 3. 3. Some of even the most tightly binding non-histone proteins could be removed from the DNA by low ionic strength salts simply by repeated washing of the chromatin. By contrast the histones were not removed by repeated washing. 4. 4. When nuclei were washed with a salt solution that closely mimicked normal intranuclear conditions the lysine-rich histone was removed from the chromatin suggesting this histone is loosely bound to DNA in vivo. 5. 5. It is pointed out that even though some nuclear sap proteins appear to be readily washed off the chromatin this does not mean they have no gene regulatory function. 6. 6. The acid-soluble non-histone proteins reported to be unique to metaphase chromosomes are shown to be the result of the adsorption of cytoplasmic proteins onto the chromosomes during the isolation procedure. 7. 7. Electrophoresis of well washed metaphase and interphase chromatin indicated their non-histone proteins were quite similar.
Does Notch Take the Sweet Road to Success

The cell surface receptor Notch is crucial for animal development, and elaborate mechanisms have evolved to control expression of the Notch gene. As [Lowe][1] describes in his Perspective, new work ([ Okajima et al .][2]) now reveals that Notch can be regulated through control of its expression at the cell surface. It turns out that egress of Notch from its site of synthesis in the endoplasmic reticulum and its subsequent transit to the cell surface via the secretory pathway is modulated by the chaperone-like activity of a fucosyltransferase enzyme. [1]: http://www.sciencemag.org/cgi/content/full/307/5715/1570 [2]: http://www.sciencemag.org/cgi/content/short/307/5715/1599
Direct photon-charged hadron coincidence measurements in STAR

The multiplicities of charged particle with transverse momentum (3 < p h ± T < 16 GeV/c) and pseudorapidity (| η | � 1.0) associated with direct photons and π 0 of high transverse momentum (8 < p γ,π 0 T < 16 GeV) at mid-rapidity (| η | � 0.9) have been measured over a broad range of centralities for Au+Au collisions and p+ p collisions at p sNN = 200 GeV in the STAR experiment. A transverse shower-shape analysis in the STAR Barrel Electromagnetic Calorimeter Shower Maximum Detector is used to discriminate between the shower of single photon and that of photons from the decays of high pT π 0 s. The relative azimuthal positions of the associated parti cles with respect to the trigger particle are constructed, and the ass ociated charged hadron yields per direct γ are extracted. An agreement is observed between the measured suppression for direct γ-trigger associated-particle yields in Au+ Au compared to that in p + p and theoretical calculations, although the uncertainties are large. Within the current uncertainties, the suppression is similar to the previously observed suppression in single-particle yields as well as in hadron-triggered associated-particle yields.
Mutagenic Effect of Temperature-Sensitive Mutants of Gene 42 (dCMP Hydroxymethylase) of Bacteriophage T4

Certain temperature-sensitive mutants of gene 42 of bacteriophage T4 increase the reversion rates of some rII mutants in the same genome by about 4 to 10 times. This effect was usually found at 34 C, an intermediate permissive temperature, but not at 28 C.
The good, the bad and the ugly science: examples from the marine science arena

Publication of this article was funded in part by the George Mason University Libraries Open Access Publishing Fund.
Effects of scheduling on the communicative assessment of aphasic patients

Abstract This study determined the influence of morning and afternoon scheduling on the assessment of communicative skills of aphasic patients. Eight short-term (3 to 9 months post-onset) and eight long-term (12 or more months post-onset) aphasic subjects were administered 11 tests from the Porch Index of Communicative Ability (PICA) at specified times in the morning ( A.M. ) and afternoon ( P.M. ). Order of scheduling ( A.M. first, P.M. second; P.M. first, A.M. second) was determined randomly but balanced between groups. Results indicated an absence of significant main effects for onset, scheduling, and test order, however, significant interactions between the scheduling and test-order factors were evidenced on the naming and auditory identification tests and on all overall measures. analyses of these interactions revealed that patients scheduled first in the A.M. decreased their mean scores when assessed a second time in the P.M. , whereas those scheduled first in the P.M. , increased their scores when seen a second time in the A.M. Findings suggest that aphasic patients can be expected to do better on morning than afternoon assessments regardless of the order in which they are scheduled. Clinically, this indicates a need for consistency in the scheduling of periodic assessments for individual aphasic patients.
Electronic transition dipole moment functions and difference potentials for transitions among low-lying states of Li2 and Na2

Abstract Electronic transition dipole moment functions based on ab initio multiconfiguration self-consistent field wavefunctions are computed for the transitions 1Σu+-1Σg+, 3Σg+-3Σu+, 1Πu-1Σg+, 3Πg-3Σu+, 1Σu+-1Πg, 3Σg+-3Πu, 1Πu-1Πg, and 3Πg-3Πu in Li2 and Na2. (In each case the states are the lowest lying of their symmetry.) We also calculate the matrix element 〈3Σu+|i(Lx - iLy)|3Πu〉 for the predissociation of the 3Πu state by the 3Σu+ state. Several unobserved spectral features are predicted.
x-space analysis for the photon structure functions in QCD

QCD predictions for the photon structure functions are analyzed with emphasis on the need of retaining hadronlike contributions. The Altarelli-Parisi formalism for the photon structure function is generalized to include next-to-leading-order corrections. Numerical results of the Altarelli-Parisi equations are presented.
Molecular dynamics simulations of hard sphere granular particles

Abstract We use molecular dynamics to study the two dimensional granular flow of particles that interact with each other via a hard sphere potential with inelastic collisions characterized by a coefficient of restitution. The particles are confined in a two dimensional box that contains a hole at the bottom through which particles flow under the influence of gravity. The particles develop coherent flow patterns that look similar to those seen in observations of real granular flow. The velocities of discharging particles through the hole is independent of the depth. We also study the fluidization of the granular particles that sets in when the bottom wall undergoes harmonic oscillation. The dense hard spehere gas is found to reproduce many of the unique features of the granular flow.
Social work textbooks on human behavior and the social environment : An analysis of the social environment component

SUMMARY This analysis of fourteen foundation frequently used Human Behavior and Social Environment (HB&SE) textbooks is based on the Council on Social Work Education's (2001) guidelines for HB&SE and a framework for integrating content related to the social environment. Specific criteria for assessment included how well the textbook reflected the reciprocal nature of human behavior and the social environment, presented a strengths perspective, incorporated diversity content, and covered material related to families, groups, organizations, communities and political economy. Three types of HB&SE textbooks were identified (life cycle, systems, and theory), and results are presented by textbook type. The findings suggest that increased attention to content related to the macro social environment and to the inter-relationships of macro, meso, and micro forces would strengthen HB&SE texts.
Medication Noncompliance and its Implications in Transplant Recipients

The transplant patient's therapeutic regimen consists of a lifelong drug therapy, including immunosuppressive drugs, prophylactic antimicrobials and often medications for the treatment of hypertension, diabetes mellitus and other comorbid diseases. Regular clinic appointments are required to monitor for signs and symptoms of immunological injury, recurrent disease and adverse drug effects. Patients are instructed to avoid risk factors for cardiovascular disease and cancer (e.g. diet, exercise, sun protection and not smoking). Noncompliance with all aspects of this regimen is substantial. Medication noncompliance leads to an increased incidence of acute rejection, chronic rejection and graft loss. Undoubtedly, many practitioners fail to appreciate the extent of noncompliance as the signs are often subtle and most patients are unwilling to disclose deliberate or widespread disregard for medication use. Newer immunosuppressive agents, particularly once-daily medications and long-acting antibody preparations offer convenience and monitoring that may improve compliance. This review focuses on the prevalence, correlates and consequences of medication nonadherence after organ transplantation. Current recommendations to enhance adherence are discussed.
Focal cerebral vasculitis associated with circulating immune complexes and brain irradiation

In this report we describe a patient with a benign glioma treated with surgery and radiation. After a period of stability he developed subacute bacterial endocarditis, and deteriorated neurologically. Computed tomographic scans did not show recurrent tumor. An angiogram showed vasculitis restricted to the previously irradiated area. Secondary to subacute bacterial endocarditis was the presence of high levels of circulating immune complexes. His neurological status was unchanged after antibiotics, but improved after treatment with dexamethasone. We interpret the clinical course as an immune-complex-mediated vasculitis superimposed on a subclinical radiation vasculitis. This case supports the hypothesis that immune mechanisms may be involved in delayed radiation injury to the nervous system.
Approximate Bandwidth Allocation for Fixed-Priority-Scheduled Periodic Resources

Recent research in compositional real-time systems has focused on determination of a component's real-time interface parameters. An important objective in interface-parameter determination is minimizing the bandwidth allocated to each component of the system while simultaneously guaranteeing component schedulability. With this goal in mind, in this paper we develop a fully-polynomial-time approximation scheme (FPTAS) for allocating bandwidth for sporadic task systems scheduled by fixed priority (e.g., deadline monotonic, rate monotonic) upon an Explicit-Deadline Periodic (EDP) resource. Our parametric algorithm takes the task system and an accuracy parameter $\epsilon ≫ 0$ as input, and returns a bandwidth which is guaranteed to be at most a factor $(1 + \epsilon)$ times the optimal minimum bandwidth required to successfully schedule the task system. By simulations over synthetically generated task systems, we observe a significant decrease in runtime and a small relative error when comparing our proposed algorithm with the exact algorithm and the sufficient algorithm.