cssi/SciSciGPT-SciSciNet huggingface dataset:
Reorganization in Primary Motor Cortex of Primates with Long-Standing Therapeutic Amputations

Intracortical microstimulation was used to investigate the organization of primate primary motor cortex (M1) in three squirrel monkeys and two galagos years after the therapeutic amputation of an injured forelimb or hindlimb. In two squirrel monkeys with forelimb amputation, physiological results were correlated with the distribution of corticospinal neurons after injections of tracers into the lower cervical segments of the spinal cord. Distributions of labeled corticospinal neurons helped identify the locations of the former forelimb cortex in M1. Evoked movements from M1 ipsilateral to the missing limb were not obviously different from M1 of normal controls. Stimulation in the deefferented part of M1 contralateral to the missing limb elicited movements of the remaining proximal muscles as well as movements from adjacent body representations in all cases. Stimulation in the deefferented forelimb cortex evoked shoulder stump, trunk, and orofacial movements, whereas stimulation in the deefferented hindlimb cortex evoked hip stump, trunk, and tail movements. Movements were evoked from all sites in the deprived cortex, so that there were no unresponsive zones. Minimal levels of current necessary to evoke these movements varied from those in the normal range to those of much higher levels, with the average threshold higher than normal. Finally, multiunit recording from the two galagos revealed that the deprived portions of S1 were responsive to touch or taps on the stump and neighboring body parts.
Access Control Policies for Semantic Networks

As web-based technologies mature, dynamic graphs of interlinked resources are replacing hierarchical catalogs as means for storing and organizing information. Such graphs,or semantic networks, often span multiple static and dynamic resources from a variety of sources. It is often highly desirable to give users access only to parts of the semantic network without breaking its logical continuity or consistency.Traditional access control models, such as mandatory, discretionary and role-based access controls, are ill-suited for these new resource structures. New models that allow users to specify access rights in terms of semantic relationships between various objects within semantic networks are needed. In this paper we discuss requirements for an access control model for semantic networks and present our approach and an initial implementation. We also describe end user tools for policy specification and assessment.
Van der Waals heterostructures for tunnel transistors

Layered semiconductors, such as transition metal dichalcogenides and black phosphorous, represent a new class of electronic materials exhibiting unique physical and chemical properties. Of particular interest for tunneling transistors (TFETs) is their inherently uniform thickness at the atomic scale arising from their layered structure. This property, theoretically leads to sharp band edges, which is an essential necessity for a steep TFET1. Furthermore, owing to their vertical quantum confinement, the depletion width at the vertical heterojunctions is confined to the van der Waals (vdW) gap. Our group has recently explored the use of various 2D material heterojunctions for TFETs, including WSe2/MoS2 heterostacks2. Our studies have shown strong interlayer coupling with gate controlled band-to-band tunneling in these vdW heterostructures. Other heterostacks with close to type III offsets have also been explored by our group, which deliver higher ON currents and steeper switching characteristics. These works demonstrate the feasibility of using 2D materials for TFETs. Significant progress has been made in the field over the past several years, however, further advancements in engineering the interface quality and contact resistance3 4 5 6 7 of vdW heterostructures are needed to explore the fundamental performance limits of 2D TFETs.
Critical Pulmonary Stenosis

This is a bit more difficult than simple valvar PS as previously discussed. Patients with critical valvar PS are cyanotic at birth and require PGE maintenance of pulmonary blood flow. Right-sided hypoplasia is rarely a limiting factor in newborns with critical PS. The appearance of a dysplastic valve, by angiography or echocardiography, has not been found to predict dilation outcome in neonates (1).
Dynamic modeling and analysis of a VTOL freewing concept

The freewing aircraft is an airplane with the wing placed on a hinged bearing about the pitch axis that allows for free rotation with respect to the fuselage body. The freewing only differs from a conventional airplane in that the wing is free to rotate. The 70 year old concept, through various studies, has been shown that by placing the wing on a freeto-rotate hinge, it effectively reduces the inertia of the wing making it easier for the wing to adjust to turbulence. The work described in this paper makes two large contributions to past freewing work. The first is the motors are placed on the wing which allows for vertical takeoff and landing (VTOL). The second is a different dynamic analysis approach that uses multi-body dynamics and uses hinge constraints as part of the state vector which allow for an easier way of solving the equations of motion. Data is shown for how the longitudinal modes change when varying design parameters. Simulation data is also presented highlighting the VTOL aspect of the vehicle.
X-Ray Photoelectron and Auger Electron Forward-Scattering Studies of the Epitaxial Growth of Fe on Ag(100)

A controversy has arisen in the past year over whether or not the growth of Fe on Ag(100) at room temperature occurs by a layer-by-layer mechanism. The present work attempts to address this controversy with an investigation of the issues, primarily by x-ray photoelectron (XPS) and Auger electron forward scattering, but with important supporting data from low-energy electron diffraction (LEED), and reflection high-energy electron diffraction (RHEED) oscillations. The results of this work suggest that the origin of the controversy lies in different substrate preparation techniques which produce different atomic step densities on the Ag(100) surface. The step sites are implicated as being the initiators of major departures from a layer-by-layer growth mode whenever most of the deposited Fe atoms have sufficient mobility to reach these steps. However, even when the Fe atoms cannot reach these steps it appears that atomic place-exchange occurs with ≥25% of the top-layer Ag atoms. Atomic place-exchange mechanisms, which could account for this intermixing, have been observed in recent molecular-dynamics simulations of epitakial growth. Thus it seems probable that under the conditions that appear to produce layer-by-layer growth, the growth begins as layer-by-layer growth of an FeAg alloy, and only becomes layer-by-layer in pure Fe as the segregating Ag atoms gradually get left behind in the growing Fe film.
Patent issues of embedded fan-out wafer/panel level packaging

In this study, the patent issues of embedded fan-out wafer/panel level packaging will be investigated. Emphasis will be placed on the claims of the granted patents and the range of things which might be covered under the patents. Depending on the redistribution-layer line width/spacing, the material, process, equipment, and application of fan-out wafer/panel level packaging are examined and some recommendations are made.
Quantitation of S-Adenosylmethionine and S-Adenosylhomocysteine in Plasma Using Liquid Chromatography-Electrospray Tandem Mass Spectrometry

We describe a simple stable isotope dilution method for accurate determination of S-adenosylmethionine (SAM) and S-adenosylhomocysteine (SAH) in plasma as a diagnostic test. SAM and SAH are key metabolic intermediates of methionine metabolism and the methylation cycle. Determination of SAM and SAH in plasma was performed by high performance liquid chromatography coupled with electrospray positive ionization tandem mass spectrometry (HPLC-ESI-MS/MS). Calibrators (SAM and SAH) and internal standards ((2)H3-SAM and (2)H4-SAH) were included in each analytical run for calibration. Sample preparation involved combining 20 μL sample with 180 μL of internal standard solution consisting of heavy isotope labeled internal standards in mobile phase A and filtering by ultracentrifugation through a 10 kd MW cutoff membrane. Sample filtrate (3 μL) was injected by a Shimadzu Nexera LC System interfaced with a 5500 QTRAP(®) (AB Sciex). Chromatographic separation was achieved on a 250 mm × 2.0 mm EA:faast column from Phenomenex. Samples were eluted at a flow rate of 0.20 mL/min with a binary gradient with a total run time of 10 min. The source operated in positive ion mode at an ion spray voltage of +5000 V. SAM and SAH resolved by a gradient to 100 % methanol with retention times of 6.0 and 5.7 min, respectively. The observed m/z values of the fragment ions were m/z 399 → 250 for SAM, m/z 385 → 136 for SAH, m/z 402 → 250 for (2)H3-SAM, m/z 203 → 46. The calibration curve was linear over the ranges of 12.5-5000 nmol/L for SAM and SAH.
Groundwater contamination: reconstructing historical knowledge for the courts

Abstract Environmental litigation in the USA seeks to establish the historical state of knowledge about the potential for groundwater contamination resulting from industrial waste disposal. To reconstruct developments that allowed a practical understanding between land disposal and groundwater pollution, this paper isolates key concepts that reveal knowledge about groundwater contamination, traces them forward, and links them to knowledge held by industrial waste managers. This systematic review reveals that professionals in waste management viewed the soil as having a limited ability to degrade wastes; they understood that organic chemicals could travel substantial distances in the subsurface, and they shared a fundamental understanding that chemical wastes had contributed to groundwater contamination before 1960.
Experience of maintaining laboratory educational website's sustainability.

Laboratory methodology websites are specialized niche websites. The visibility of a niche website transforms it into an authority site on a particular niche of knowledge. This article presents some ways in which a laboratory methodology website can maintain its sustainability. The optimal composition of the website includes a basic content, a blog, and an ancillary part. This article discusses experimenting with the search engine optimization query results page. Strategic placement of keywords and even phrases, as well as fragmentation of the post's material, can improve the website's visibility to search engines. Hyperlinks open a chain reaction of additional links and draw attention to the previous posts. Publications in printed periodicals are a substantial part of a niche website presence on the Internet. Although this article explores a laboratory website on the basis of our hands-on expertise maintaining Grossing Technology in Surgical Pathology (www.grossing-technology.com) website with a high volume of traffic for more than a decade, the recommendations presented here for developing an authority website can be applied to other professional specialized websites. The authority websites visibility and sustainability are preconditions for aggregating them in a specialized educational laboratory portal.
Bortezomib Alters Peripheral Blood Lymphocyte Subsets in Patients with Multiple Myeloma.

Abstract Bortezomib (VELCADE®) is a potent inhibitor of the proteasome which exerts its antimyeloma effect in part by blocking the activation of NF-κB. As NF-κB is critical for lymphocyte development and survival, there is great interest in harnessing the potential immunomodulatory effects of bortezomib. In murine hematopoietic transplantation models, bortezomib inhibits in vitro mixed lymphocyte responses and promotes the apoptosis of alloreactive T cells protecting against acute graft-versus-host disease. However, no data exists on the in vivo effects of bortezomib on human T cells. To characterize the effects of bortezomib on immune function, we profiled peripheral blood lymphocytes subsets and T cell associated cytokines in 39 patients with multiple myeloma. Two cycles of bortezomib 1.3 mg/m2 were administered by intravenous infusion on days 1, 4, 8, and 11 of a 21-day treatment cycle. The patients had received prior induction chemotherapy and would proceed to autologous transplant following treatment with bortezomib. Study population consists of 23 male and 16 female patients with the median age of 56 years (range 38–69). Myeloma characteristics at diagnosis were as follows (number of patients): IgG (28), IgA (10), light chain only (1), with stage I (1), II (12), or stage III (26) disease. Peripheral blood was collected at baseline (cycle 1, day 1) and at one week after the last dose of bortezomib (cycle 2, day 18) and analyzed for lymphocyte subsets by standard multicolor flow cytometry. Th1 and Th2 serum cytokines were measured at the same timepoints using a multiplexed cytometric bead array (BD Biosciences). Following treatment with bortezomib, no significant changes were detected in either Th1 or Th2 serum cytokine levels: IL-2 (p=0.116), TNF-alpha (p=0.854), IFN-gamma (p=0.070), IL-4 (p=0.240), IL-6 (0.236), IL-10 (0.151) as analyzed by Wilcoxon signed ranks test. Analysis of lymphocyte subsets using a paired student's T-test demonstrated a 38% decrease in CD56+ NK cells (p=0.02) and a 26% increase in CD4/CD8 ratio (p=0.0006) which appears to be secondary to a decrease in CD8+ cytotoxic T-cells (p=0.054). (Table 1.) In conclusion, we observe an alteration of lymphocyte subsets following only two cycles of bortezomib. Further analysis of the effects of long term treatment with bortezomib is warranted. These studies may provide insights into the role of bortezomib as an immunomodulatory agent. Peripheral Blood Lymphocyte Subsets Pre-bortezomib (/mm 3 ) Post-bortezomib(/mm 3 ) Difference(/mm 3 ) P-value CD2 1446 1259 −187 0.085 CD3 1273 1160 −113 0.28 CD4 842 802 −40 0.54 CD8 412 337 −75 0.055 CD19 90 94 4 0.86 CD20 87 95 8 0.78 CD56 206 148 −58 0.022 CD4/CD8 ratio 2.53 3.19 0.66 0.0006
The influence of the capillary pressure in nanobubbles on their attachment to particles during froth flotation: Part IV. Spreading nanobubbles as natural fractals

The specific property of nanobubbles with spontaneous spreading over the solid hydrophobic particle substrate adhered to them, which is caused by a high capillary gas pressure in nanobubbles (Pc > 106 N/m2), is considered. The computational principle of bubble spreading curves is considered and parameter X characterizing the intensity is introduced. Dependence X(a) (a is the bubble base diameter) is presented by a bimodal curve, which confirms that the nanobubble spreading is energetically provided by two sequentially acting independent sources. The first source is conditioned by the reduction (approximately by 11%) of the nanobubble curvilinear surface area at the initial spreading stage, and the second source is conditioned by the work of gas expansion caused by the drop of Pc when the bubble is spreading. Parameter X is characterized by a considerably larger slope of dependence X(a) at the first spreading stage compared to the second one. It now turned out that the revealed property, which determines the efficiency of industrial flotation processes in past, finds prospects for application again after its recognition. Since it manifests itself in a limited range of bubble sizes, it is proposed to attribute it to the proper or natural fractal by analogy with the Brownian motion, which manifests itself in a definite range of particle sizes. The influence of the surface activity of flotation reagents on the shape of bubble spreading curves is shown.
Frequency domain analysis of triggered lightning return stroke luminosity velocity

Fourier analysis is applied to time-domain return-stroke luminosity signals to calculate the phase and group velocities and the amplitude of the luminosity signals as a function of frequency measured between 4 m and 115 m during twelve triggered lightning strokes. We show that pairs of time-domain luminosity signals measured at different heights can be interpreted as the input and the output of a system whose frequency-domain transfer function can be determined from the measured time-domain signals. From the frequency-domain transfer function phase we find the phase and group velocities, and luminosity amplitude as a function of triggered lightning channel height and signal frequency ranging from 50 kHz to 300 kHz. We show that higher frequency luminosity components propagate faster than the lower frequency components and that higher frequency luminosity components attenuate more rapidly than lower frequency components. Finally, we calculate time-domain return stroke velocities as a function of channel height using two time-delay techniques: 1) measurement at the 20% amplitude level, and 2) cross-correlation.
Washington Women: Practicing Geography in the U.S. Government, 1915–1970s

Histories of geography, especially those dealing with the twentieth century, tend to focus on geographic thought or academia rather than on practice in other arenas such as government agencies. In the United States during that period, however, the latter included a higher proportional representation of women professionals than did research-oriented universities. This article examines the careers of selected women geographers who had long-term and senior positions in Washington, DC, in agencies such as the Library of Congress, Bureau of the Census, the Department of State, and the Office of Naval Research. Drawing on sources including directories, the archives and oral history collections of the Society of Woman Geographers, and interviews conducted in the late 1980s and early 1990s, I explore four main themes: how these women came to government work, aspects of the intersections of personal and professional lives, ways in which economic and political contexts shaped their opportunities and experiences, an...
Prospective cardiac motion self-gating

Objective: To develop a prospective cardiac motion self-gating method that provides robust and accurate cardiac triggers in real time. Methods: The proposed self-gating method consists of an “imaging mode” that acquires the k-space segments and a “self-gating mode” that captures the cardiac motion by repeatedly sampling the k-space centerline. A training based principal component analysis algorithm is utilized to process the self-gating data where the projection onto the first principal component was used as the self-gating signal. Retrospective studies using a sequence with self-gating mode only was performed on 8 healthy subjects to validate the accuracy and reliability of the self-gating triggers. Prospective studies using both ECG-gated and self-gated cardiac CINE sequences were conducted on 6 healthy subjects to compare the image quality. Results: Using the ECG as the reference, the proposed method was able to detect self-gating triggers within ±10ms accuracy on all 8 subjects in the retrospective study. The prospectively self-gated CINE sequence successfully detected 100% of the cardiac triggers and provided excellent CINE image quality without using ECG signals. Conclusions: The proposed cardiac self-gating method is a robust and accurate alternative to conventional ECG-based gating method for a number of cardiac MRI applications.
Fighting State Terror and Becoming the State: Argentina’s Human Rights Movement from Mass Mobilization to Institutionalization

The past decade has seen a seismic shift in Argentine human rights activists’ ability to accomplish long-held goals of bringing perpetrators to justice and preserving the memory of victims of the Civil-State dictatorship of the 1970s and 1980s. Theories of courageous resistance to injustice posit that all struggles for justice bring changes to the context, networks and people, which can make future pro-social advocacy more likely. Using a variety of evidence, we assess the impact of nearly 40 years of sustained activism. We argue that there are resulting shifts in the realms of 1) context (newly created and modified legal and state institutions, cultural changes and modification of the physical landscape), 2) relationships between activists, society and the Argentine state, and 3) socialization factors that affect attitudes and behaviors of Argentines (the ways that the era is referenced, taught and memorialized). We contend that each of these enduring legacies of activism make future human rights atrocities in Argentina highly unlikely. Further, we argue that because of these enormous gains, segments of the movement struggle to define themselves relative to the state, trying to avoid being captured by governmental interests and to maintain sufficient independence to effectively pressure the state.
Association of Reference Pricing with Drug Selection and Spending

BackgroundIn the United States, prices for therapeutically similar drugs vary widely, which has prompted efforts by public and private insurers to steer patients toward the lower-priced options. Under reference pricing, the insurer or employer establishes a maximum contribution it will make toward the price of a drug or procedure, and the patient pays the remainder. MethodsWe used difference-in-differences multivariable regression methods to analyze changes in prescriptions and pricing for 1302 drugs in 78 therapeutic classes in the United States, before and after implementation of reference pricing by an alliance of private employers. We assessed trends for the study group relative to those for an employee group that was not subject to reference pricing. The study included 1,122,741 prescriptions that were reimbursed during the period from 2010 through 2014. ResultsImplementation of reference pricing was associated with a higher percentage of prescriptions that were filled for the lowest-priced reference...
Centromere Size and Its Relationship to Haploid Formation in Plants

Wide species crosses often result in uniparental genome elimination and visible failures in centromere function. Crosses involving lines with mutated forms of the CENH3 histone variant that organizes the centromere/kinetochore interface have been shown to have similar effects, inducing haploids at high frequencies. Here, we propose a simple centromere size model that endeavors to explain both observations. It is based on the idea of a quantitative centromere architecture where each centromere in an individual is the same size, and the average size is dictated by a natural equilibrium between bound and unbound CENH3 (and its chaperones or binding proteins). While centromere size is determined by the cellular milieu, centromere positions are heritable and defined by the interactions of a small set of proteins that bind to both DNA and CENH3. Lines with defective or mutated CENH3 have a lower loading capacity and support smaller centromeres. In cases where a line with small or defective centromeres is crossed to a line with larger or normal centromeres, the smaller/defective centromeres are selectively degraded or not maintained, resulting in chromosome loss from the small-centromere parent. The model is testable and generalizable, and helps to explain the counterintuitive observation that inducer lines do not induce haploids when crossed to themselves.
Magneto-optical properties of BaTiO3/La0.76Sr0.24MnO3/BaTiO3 heterostructures

The magnetic properties of epitaxial BaTiO3/La0.76Sr0.24MnO3/BaTiO3 (BTO/LSMO/BTO) heterostructures have been studied using magneto-optic Kerr effect (MOKE) technique. Both longitudinal and polar MOKE were probed as a function of magnetic field and temperature (in the range between 80 and 320 K) for epitaxial films of BTO/LSMO/BTO and LSMO grown on TiO2-terminated SrTiO3 (001) substrates by pulsed laser deposition technique. The LSMO film without the BTO layers exhibits nearly square field-dependent MOKE hysteresis loops with low saturation fields below a bulk-like Curie temperature (TC) of ∼ 350K. In contrast, the film with the BTO layers exhibits a significantly suppressed TC of 155 K, accompanied by significantly enhanced coercive fields and perpendicular magnetic anisotropy.
Insights on surface-water/groundwater exchange in the upper Floridan aquifer, north-central Florida (USA), from streamflow data and numerical modeling

Surface-water/groundwater exchange impacts water quality and budgets. In karst aquifers, these exchanges also play an important role in dissolution. Five years of river discharge data were analyzed and a transient groundwater flow model was developed to evaluate large-scale temporal and spatial variations of exchange between an 80-km stretch of the Suwannee River in north-central Florida (USA) and the karstic upper Floridan aquifer. The one-layer transient groundwater flow model was calibrated using groundwater levels from 59 monitoring wells, and fluxes were compared to the exchange calculated from discharge data. Both the numerical modeling and the discharge analysis suggest that the Suwannee River loses water under both low- and high-stage conditions. River losses appear greatest at the inside of a large meander, and the former river water may continue across the meander within the aquifer rather than return to the river. In addition, the numerical model calibration reveals that aquifer transmissivity is elevated within this large meander, which is consistent with enhanced dissolution due to river losses. The results show the importance of temporal and spatial variations in head gradients to exchange between streams and karst aquifers and dissolution of the aquifers.
Totem and Taboo

Freud’s interest in the origins of guilt came relatively late in his work, as he himself acknowledged (1933). It was only after his major clinical accounts had been written that Freud undertook a study of the origins of guilt in Totem and Taboo. In his clinical papers, as well as in his books on dreams and jokes, “disgust, shame, and morality” were simply the counterforces against which sexual longings (libido) contended. Moreover, the origin of these counterforces was at first located in the sexual instincts themselves (see Chapter 4) as sublimations and reaction formations of the sexual instincts. Hostility arose out of frustrated libido; sublimations and reaction formations of hostility (although in the service of the “ego-instincts”) also made use of the energy of the sexual instincts to deflect them into social and moral purposes. In this account, libido theory is the centerpiece of the explanation. Our path might have been easier if Freud had indeed regarded his libido theory as a theory of the emotions (as he said he did in Group Psychology, 1921, p. 90). If one permits libido to stand for the attachment emotions, the origin of hostility and morality in a single source becomes a viable hypothesis. Morality is the affective-cognitive outcome of attachment. Threatened attachment, which first evokes protest aimed at the caretaker—“other,” is then transformed, mainly by identification, into states of shame and guilt that aim at maintaining the attachment.
Teacher Ratings of Hyperactivity, Inattention, and Conduct Problems in Preschoolers

Age and sex norms of classroom behavior in preschoolers were established on a standard measure, the Revised Conners Teacher Rating Scale, and the utility of this measure for assessing problem behavior in preschoolers was examined. Teachers provided ratings for 455 nonreferred preschoolers. In addition, ratings were obtained for 12 clinically referred preschoolers diagnosed with attention deficit hyperactivity disorder. The Conduct Problems, Inattention, and Hyperactivity subscales, as well as the Hyperactivity Index, were found to have good internal reliability and were related to each other in predictable ways. Normative data are presented by age and sex. Age was inversely related to scores for the Conduct Problems subscale, the Hyperactivity subscale and the Index. Sex was a significant predictor of subscale scores, with boys receiving higher scores than girls. Subscale scores and nearly all item scores were highly significantly different between clinically referred and nonreferred preschoolers. The results provide a standard upon which to evaluate preschool-aged children in clinical and research settings.
A widespread Neotropical Bradyrhizobium lineage associated with Machaerium and Desmodium (Papilionoideae)

Multilocus enzyme electrophoresis and ribosomal RNA gene sequencing were used to compare bacterial strains from the liana Machaerium milliflorum and the herb Desmodium axillare at two lowland forests 440 km apart in Panama and Costa Rica. Out of 27 multilocus genotypes (electrophoretic types or ETs) detected in the isozyme analysis, only two ETs were found in both locations. Nevertheless, these shared ETs were closely related to a cluster including 11 other common ETs that represented 72% and 80%, respectively, of all bacterial isolates sampled in Panama and Costa Rica. Isolates in this group from both locations and from both legume hosts all had identical sequences for a highly polymorphic 5′ portion of 23S rRNA, while nine other ETs outside this cluster all had unique sequences. This indicates that both sites are occupied by one primary lineage of nodule symbionts that is both locally predominant and geographically widespread. However, this group coexists with numerous other rare bacterial lineages whose ecology, distribution, and relationships require further study.
"Much Madness is divinest Sense": The Economic Consequences of Yahweh's Parasocial Identity

The historical development of Israelite theology must be understood in relation to the social antagonisms that shaped the contexts in which people spoke about God. This article brings recent research on the historical development of different institutional forms in ancient Israelite society into conversation with recent arguments regarding the origins and evolution of the worship of Yahweh in the southern Levant.My aim is not to reduce theology to an epiphenomenal reflection or a direct expression of social realities, but to grasp it as creatively engaged with such realities. Yahweh appears to have originated among mobile bands on the social and geographical margins with respect to the centers of political and economic power in southwest Asia. Israel’s emergent monarchic state adopted this popular family god as its patron deity. The real social antagonisms between extractive state regimes and sustainable systems of allocation shaped—in various, indirect, and surprising ways—Israel’s speech about God. This article argues that the conflicted historical development of Israel’s speech about Yahweh takes its shape in relation to the evolving social regimes and antagonisms that marked Israel’s history.
Anticoagulant rodenticide toxicosis causing tracheal collapse in 4 small breed dogs.

OBJECTIVE To describe 4 cases of tracheal narrowing attributed to tracheal mucosal hemorrhage caused by anticoagulant rodenticide toxicity in breeds predisposed to tracheal collapse. CASE SUMMARY Over the years 2005-2014, 4 dogs were presented for respiratory distress secondary to diffuse tracheal narrowing. All dogs had possible anticoagulant rodenticide ingestion and prolonged prothrombin time. All dogs received fresh-frozen plasma transfusions, vitamin K1 supplementation, and supportive care. Tracheal narrowing improved on follow-up radiographs in 3 of 4 patients. One of 4 did not have follow-up radiographs performed. All dogs survived. NEW OR UNIQUE INFORMATION PROVIDED Anticoagulant rodenticide toxicity causing clinical signs consistent with tracheal collapse is a rare but recognized phenomenon that has not been previously reported in breeds prone to tracheal collapse.
Noninfectious Fever in Aneurysmal Subarachnoid Hemorrhage: Association with Cerebral Vasospasm and Clinical Outcome

Objective The purpose of this study was to evaluate the association between noninfectious fever onset and radiographic vasospasm, delayed ischemic neurologic deficit (DIND), delayed cerebral infarction (DCI), and clinical outcome in patients with aneurysmal subarachnoid hemorrhage. Methods We evaluated 44 patients for the association between noninfectious fever (greater than 101.5°F) and the development of radiographic vasospasm by digital subtraction angiography (DSA) and transcranial Doppler (TCD), DIND, DCI, and modified Rankin scale outcome score at 6 months to 2 years. Multivariate logistic regression analyses were performed to account for patient age, sex, admission Hunt and Hess grade, and Fisher grade. TCD was additionally used for temporal analysis. Results Noninfectious fever was significantly associated with radiographic vasospasm using both DSA (odds ratio [OR], 2.2; 95% confidence interval [CI], 1.2–4.5; P = 0.02) and TCD (OR, 2.4; 95% CI, 1.2–5.6; P = 0.02), but it was not associated with DIND, DCI, or outcome. The maximum cross correlation between TCD velocity and temperature occurred for temperatures taken 1 day prior to TCD velocity measurement. A quadratic mixed-effects model demonstrated that TCD velocity was significantly associated with temperature from 1 day prior to TCD velocity measurement (β = 13.5; 95% CI, 0.83–8.79, P = 0.01), posthemorrhage day (β = 20.1; 95% CI, 2.14–7.52; P Conclusions Noninfectious fever was associated with the development of radiographic vasospasm but not with DIND, DCI, or clinical outcome. Furthermore, there is a temporal association between the onset of noninfectious fever and radiographic vasospasm by 1 day. Fever independent of patient's infectious profile may be an early marker for the development of radiographic vasospasm.
Evaluation of post-weld heat treatments applied to FeCrAl alloy weldments

Abstract The nuclear incident at the Fukushima Daiichi nuclear power plant has created a strong push for accident-tolerant fuel cladding to replace current zirconium-based cladding. A current near-term focus on iron-chromium-aluminum (FeCrAl) alloys. Laser-welded FeCrAl samples (C35MN, C37M, and C35M10 TC) were subjected to three different post-weld heat treatment regimes: 650 °C for 5 h, 850 °C for 1 h, and 850 °C for 5 h. The samples were then analyzed using optical light microscopy, micro-hardness indentation, and scanning electron microscopy coupled with energy-dispersive spectroscopy and electron backscatter diffraction. The base microstructure of C37M and C35M10 TC experienced significant grain coarsening outside the fusion zone due to the applied post-weld heat treatments, whereas Nb-rich precipitation in C35MN limited grain growth compared with the other alloys studied.
Visionary architecture of utopian communities

Abstract: Utopian communities have often built distinctive homes, temples, and other structures, in many cases reflecting the visionary perspectives of their founders and members. Sometimes the visionary architecture of utopian communities leads to experimental construction methods; sometimes it leads to the erection of large symbolic statues and other monumental structures; sometimes it reflects a concern for preservation of the environment. This heavily illustrated paper features examples of architecture, including landscape architecture, from several communities and religious movements of the past and present: Drop City, Damanhur, Findhorn, Tama-Re, Tamera, the Holy City of the Mandarom, Dancing Rabbit, Libre, New Harmony, Hancock Shaker Village, Yogaville, Kashi Ashram, Point Loma, the Temple of the People, Arcosanti, the Koreshan Unity, New Vrindaban, and several others. It also includes illustrations of visionary architectural projects that were never built.
Impact of the partnership between Japanese Society of Gastroenterological Surgery, Society of Surgical Oncology, and Annals of Surgical Oncology .

The Society of Surgical Oncology (SSO) and its official journal, Annals of Surgical Oncology, have had a very important and successful partnership with the Japanese Society of Gastroenterological Surgery (JSGS). This partnership has advanced our missions of promoting high-quality surgical science focused on improving patient outcomes.
SR9009 Has REV-ERB-independent Effects on Cell Proliferation and Metabolism

The nuclear receptors REV-ERBα and -β link circadian rhythms and metabolism. Like other nuclear receptors, REV-ERB activity can be regulated by ligands, including naturally occurring heme. A putative ligand, SR9009, has been reported to elicit a range of beneficial effects in healthy as well as diseased animal models and cell systems. However, the direct involvement of REV-ERBs in these effects of SR9009 has not been thoroughly assessed, as experiments were not performed in the complete absence of both proteins. Here, we report the generation of a mouse model for conditional genetic deletion of REV-ERBα and -β. We show that SR9009 can decrease cell viability, rewire cellular metabolism, and alter gene transcription in hepatocytes and embryonic stem cells lacking both REV-ERBα and -β. Thus, the effects of SR9009 cannot be used solely as surrogate for REV-ERB activity.
Teaching an Old Dog New Tricks: Machine Learning anImproved TIP3P Potential Model for Liquid–Vapor Phase Phenomena

Water is ubiquitous yet displays a rich variety of thermodynamic properties and anomalies. An understanding of liquid–vapor phenomena in water is of broad importance to everyday processes such as e...
The statistical eigenvector analysis technique (SEAT) for dip data analysis

Abstract Dip data acquired from image logs (i.e. the dip/azimuth of planar features) are extensively used in the oil and gas industry to assist in interpreting subsurface geology. Gradual and/or abrupt variations in dip data with depth may indicate different structural features (e.g. faults, folds, etc.) or changes to sedimentary systems (e.g. unconformity). The statistical eigenvector analysis technique (SEAT) and accompanying computer application are useful in statistically calculating the orientation and geometry of subsurface structures from dip data. Poles to planes on a spherical projection over a given depth interval may reveal cluster or girdle distributions, which can be interactively analyzed using statistical distribution functions on the unit sphere. SEAT provides a mathematical solution for as few as two data points, and has the potential to be applied to dip data at the meter-scale. The orientation and geometry of various subsurface geological features (e.g. folds, fault drag deformation, etc.) can be interactively calculated over a chosen depth interval. SEAT is applied to a dip dataset acquired from a modern, 8-padded electronic borehole image log and a previously studied dipmeter data from the discovery well of the Railroad Gap Field to illustrate its higher accuracy in determining the orientation and geometry of subsurface structures compared to older methods. SEAT allows for a vastly improved interpretation of subsurface geological features when combined with high-resolution borehole image logs and accurate dip data. Improved understanding of subsurface geometries may allow for better business decisions in future exploration and appraisal of existing assets.
User-Aware Shared Perception for Embodied Agents

We present Diana, an embodied agent who is aware of her own virtual space and the physical space around her. Using video and depth sensors, Diana attends to the user's gestures, body language, gaze and (soon) facial expressions as well as their words. Diana also gestures and emotes in addition to speaking, and exists in a 3D virtual world that the user can see. This produces symmetric and shared perception, in the sense that Diana can see the user, the user can see Diana, and both can see the virtual world. The result is an embodied agent that begins to develop the conceit that the user is interacting with a peer rather than a program.
Workers on arrival black labor in the making of America: by Joe William Trotter Jr., Berkeley, University of California, 2019,328pp., $29.95 (hardback), ISBN 9780520299450

Joe William Trotter Jr.’s Workers on Arrival: Black Labor in the Making of America rewrites the history of the United States through the empirical site of Black labour. In this epochal socio-histor...
Diagnosis of Amyloidosis: A Survey of Current Awareness and Clinical Challenges Among Cardiologists in Switzerland

Transthyretin amyloidosis (ATTR) is a progressive disease in which amyloid fibril deposition disrupts tissue structure and organ function. Many patients with ATTR present with cardiac involvement; recent studies indicate that ATTR prevalence is higher than expected in patients with certain heart conditions. Although long delays to diagnosis are common, recent treatment advances have made timely diagnosis critical to ensure appropriate patient management. Despite clinical guideline updates, it remains unclear how these are being implemented in routine patient care. We performed a survey of practicing cardiologists in Switzerland to assess their knowledge of ATTR and current clinical practice. Overall, 72 cardiologists completed the questionnaire in a face-to-face interview (n = 16) or online (n = 56). Key findings highlighted wide variation in cardiologists’ knowledge about the diagnostic tests required for a differential diagnosis of ATTR. In particular, many cardiologists lacked familiarity with radiolabeled bone scintigraphy, an important non-invasive test that is part of the diagnostic algorithm for ATTR. Another challenge in diagnosing amyloidosis appears to be general awareness of ATTR among cardiologists. Survey results highlight that cardiologists in Switzerland would benefit from information on the latest advances in ATTR to support them in screening heart failure patients and ensure that patients benefit from treatment advances.
Compositionally Controlled Polyether Membranes via Mono(μ-alkoxo)bis(alkylaluminum)-Initiated Chain-Growth Network Epoxide Polymerization: Synthesis and Transport Properties

The addition of a diglycidyl-ether to a mono(μ-alkoxo)bis(alkylaluminum)-initiated epoxide polymerization presents a strategy for amorphous polyether-based membrane synthesis. In situ kinetic 1H NM...
The therapeutic efficacy of Qigong exercise on the main symptoms of fibromyalgia: A pilot randomized clinical trial.

Abstract Background Some of the most debilitating symptoms of fibromyalgia (FM) include widespread chronic pain, sleep disturbances, chronic fatigue, anxiety, and depression. Yet, there is a lack of effective self-management exercise interventions capable of alleviating FM symptoms. The objective of this study is to examine the efficacy of a 10-week daily Qigong, a mind–body intervention program, on FM symptoms. Methods 20 participants with FM were randomly assigned to Qigong (experimental) or sham-Qigong (control) groups, with participants blinded to the intervention allocation. The Qigong group practiced mild body movements synchronized with deep diaphragmatic breathing and meditation. The sham-Qigong group practiced only mild body movements. Both groups practiced the interventions two times per day at home, plus one weekly group practice session with a Qigong instructor. Primary outcomes were: pain changes measured by the Short-Form McGill Pain Questionnaire, a visual analog scale for pain, pressure pain threshold measured by a dolorimeter. Secondary outcomes were: the Revised Fibromyalgia Impact Questionnaire the Pittsburgh Sleep Quality Index, the Hospital Anxiety and Depression Scale and the Quality of Life Scale. Results The experimental group experienced greater clinical improvements when compared to the control group on the mean score differences of pain, sleep quality, chronic fatigue, anxiety, depression, and fibromyalgia impact, all being statistically significant at p Conclusion Daily practice of Qigong appears to have a positive impact on the main fibromyalgia symptoms that is beyond group interaction. Trial registration ClinicalTrials.gov NCT03441997.
Neuromuscular response to a single session of whole-body vibration in children with cerebral palsy: A pilot study.

Abstract Background Whole-body vibration (WBV) is a relative new intervention paradigm that could reduce spasticity and improve motor function in children with cerebral palsy (CP). We investigated neuromuscular response to a single session of side-alternating WBV with different amplitudes in children with CP. Methods Ten children with spastic CP aged 7–17 years at GMFCS level I-III participated in this pilot study. Participants received two sessions of side-alternating WBV with the same frequency (20 Hz) but different amplitudes (low-amplitude: 1 mm and high-amplitude: 2 mm). Each session included six sets of 90 s of WBV and 90 s of rest. Before and after each WBV session, we used (a) the modified Ashworth scale to evaluate the spasticity of the participants' leg muscles, (b) a quiet standing task to analyze center-of-pressure (CoP) pattern and postural control, and (c) overground walking trials to assess spatiotemporal gait parameters and joint range-of-motion (RoM). Results Both WBV sessions similarly reduced the spasticity of the ankle plantarflexors, improved long-range correlation of CoP profile during standing, and reduced muscle activity of tibialis anterior during walking. The high-amplitude WBV further increased ankle RoM during walking. Conclusions This study demonstrates that a single session of WBV with either a low or a high amplitude can reduce spasticity, enhance standing posture, and improve gait patterns in children with CP. It suggests that low-amplitude WBV may induce similar neuromuscular response as high-amplitude WBV in children with spastic CP and can provide positive outcomes for those who are not able to tolerate stronger vibration.
The role of binders in mixture cracking resistance measured by ideal-CT test

Abstract The Indirect Tensile Asphalt Cracking Test (IDEAL-CT) is a newly developed test method that has high potential of reliably evaluating fatigue cracking of asphalt mixtures. In this study two binder fatigue testes, Linear Amplitude Sweep (LAS) and Binder Yield Energy Test (BYET), were used to measure the performance of asphalt binders. Advanced analyses on LAS/BYET data were employed to determine binder fatigue parameters that could explain binder’s role in mixture cracking resistance. The results indicate that the role of binders in mixture behavior in the IDEAL-CT tests can be successfully defined using the outputs from the LAS and BYET tests.
Characteristics of Apomorphine Tachyphylaxis

ABSTRACT We have examined the blockade of norepinephrine (NE) and dopamine (DA) during apomorphine (APO) tachyphylaxis in isolated aortic strips from both mature (10–12 wks) and young (3–5 wks) rabbits. APO 3 × 10 −4 M (20 min incubation; 30 min wash) shifted dose-response (DR) curves for both NE and DA to the right. Larger displacements were seen when tissues derived from young animals were examined. When corrected for changes in tissue sensitivity by comparison with internal controls, the NE and DA shifts were not significantly different. A non-adrenergic blockade during APO tachyphylaxis is ruled out since histamine DR curves were only minimally shifted and KCl DR curves were slightly potentiated. Since NE and DA are blocked to the same extent by APO, it seems likely that DA and APO act mainly on ±-adrenoceptors of rabbit aorta. Shifts in DR curves during a combination of APO tachyphylaxis and phentolamine (10 −7 M) blockade were compared to those of the individual treatments. Shifts in DR curves to NE, oxymetazoline, and methoxamine after APO tachyphylaxis were not significantly different from one another nor were those after combination treatment. Analysis of the combination studies suggests that the blockades produced by APO and PTA are multiplicative and indicative of actions by those agents on 2 independent but interrelated loci. The time course of dissociation of tritium from aortic tissue incubated with 3 H-APO was examined, and the decline of 3 H-APO bound/mg tissue was found to be log linear with time (t 1/2 = 20 min). Significant amounts of 3 H-APO binding could be demonstrated at the time during APO tachyphylaxis when blockade of α-agonists is observed.