cssi/SciSciGPT-SciSciNet huggingface dataset:
HOW WE LIVE WITH THE PAST NOW

Michael Roth's new collection of essays, written over the last two decades, is held together by its author's pervasive concern with human temporality: our individual and collective passages through time, recorded by the faculty of memory, which pose some of our most intractable problems. The essays treat, and indeed provide a map to, several adjacent areas of inquiry: the history of the psychopathology of memory in the long nineteenth century; the vicissitudes of the trauma-concept from its relatively modest medical origins to its postmodern apotheosis; and photography as a medium and art form embroiled in our relationship with the past. Roth's major interventions are threefold. First, while persuaded of the value of the psychoanalytic version of the trauma-concept, he critiques the so-called traumatophilia of postmodern theorists who, usually with reference to the Holocaust, seek to invest trauma with ethical valences and powers of legitimation or even, as in the case of Agamben, raise it to ontological status. Second, through his fine-grained account of Freud's convergence with and divergence from his French colleagues, especially Charcot and Janet, Roth argues that the stunning breakthrough of psychoanalysis was to take the past seriously, to recognize the inevitable penetration of the past into the present in the human psyche as well our affective investment in and need to narrativize the past. For Roth, Freud's continued relevance today resides in what he has taught us about living with the past. Finally, Roth begins to develop the concept of “piety” as an attitude toward the past that fuels the writing of history. He leaves the concept in rudimentary form, but his evocative remarks suggest the fruitfulness of developing it further.
Using Witness Confidence can Impair the Ability to Detect Deception

Prior research has shown that jurors rely on confidence in discriminating between accurate and inaccurate testimonies despite the weak relationship between the two. The purpose of this study is to ...
Preliminary Test of a Real-Time, Interactive Silent Speech Interface Based on Electromagnetic Articulograph

A silent speech interface (SSI) maps articulatory movement data to speech output. Although still in experimental stages, silent speech interfaces hold significant potential for facilitating oral communication in persons after laryngectomy or with other severe voice impairments. Despite the recent efforts on silent speech recognition algorithm development using offline data analysis, online test of SSIs have rarely been conducted. In this paper, we present a preliminary, online test of a real-time, interactive SSI based on electromagnetic motion tracking. The SSI played back synthesized speech sounds in response to the user’s tongue and lip movements. Three English talkers participated in this test, where they mouthed (silently articulated) phrases using the device to complete a phrase-reading task. Among the three participants, 96.67% to 100% of the mouthed phrases were correctly recognized and corresponding synthesized sounds were played after a short delay. Furthermore, one participant demonstrated the feasibility of using the SSI for a short conversation. The experimental results demonstrated the feasibility and potential of silent speech interfaces based on electromagnetic articulograph for future clinical applications.
Coded Harmonic Imaging in the Evaluation of Posterior Tibial Tendon Injury

Coded harmonic imaging has excellent contrast resolution and is very advantageous in diagnosing musculoskeletal pathology. In this article, the authors present a case of a posterior tibial tendon tear using coded harmonics to best define the extent and type of injury for better treatment.
Caste- and development-associated gene expression in a lower termite.

Background: Social insects such as termites express dramatic polyphenism (the occurrence of multiple forms in a species on the basis of differential gene expression) both in association with caste differentiation and between castes after differentiation. We have used cDNA macroarrays to compare gene expression between polyphenic castes and intermediary developmental stages of the termite Reticulitermes flavipes. Results: We identified differentially expressed genes from nine ontogenic categories. Quantitative PCR was used to quantify precise differences in gene expression between castes and between intermediary developmental stages. We found worker and nymph-biased expression of transcripts encoding termite and endosymbiont cellulases; presoldier-biased expression of transcripts encoding the storage/hormone-binding protein vitellogenin; and soldier-biased expression of gene transcripts encoding two transcription/translation factors, two signal transduction factors and four cytoskeletal/muscle proteins. The two transcription/translation factors showed significant homology to the bicaudal and bric-a-brac developmental genes of Drosophila. Conclusions: Our results show differential expression of regulatory, structural and enzymecoding genes in association with termite castes and their developmental precursor stages. They also provide the first glimpse into how insect endosymbiont cellulase gene expression can vary in association with the caste of a host. These findings shed light on molecular processes associated with termite biology, polyphenism, caste differentiation and development and highlight potentially interesting variations in developmental themes between termites, other insects, and higher animals.
Another Look at the Conformity Explanation of Group-Induced Shifts in Choice

A conformity explanation of group-induced shifts in individual choice has never received careful examination. For conformity to account for groupinduced shifts, it must be shown that (a) movement toward the group produces shifts in predictable directions on given decision problems, and (b) the motive force behind individual changes is group pressure. This article reviews the evidence bearing upon these two propositions and compares conformity with other currently popular explanations of the choice shift. The conclusion drawn is that conformity cannot account for the full choice shift effect, but that it does explain a significant portion of the variance in individual shifts.
Functional tissue-engineered blood vessels from bone marrow progenitor cells

Objective Stem cells have significant potential for development of cell-based therapeutics for cardiovascular tissue regeneration. Methods We developed a novel method for isolating smooth muscle cells (SMC) from ovine bone marrow using a tissue-specific promoter and fluorescence-activated cell sorting. Results As compared to vascular SMC, bone marrow-derived smooth muscle progenitor cells (BM-SMPC) exhibited similar morphology, showed higher proliferation potential and expressed several SMC markers including α-actin, calponin, myosin heavy chain, smoothelin, caldesmon and SM22. When embedded in fibrin hydrogels, BM-SMPC contracted the matrix and displayed receptor- and non-receptor-mediated contractility, indicating that BM-SMPC can generate force in response to vasoreactive agonists. We also prepared tissue-engineered blood vessels from BM-SMPC and BM-derived endothelial cells and implanted them into the jugular veins of lambs. As early as five weeks post-implantation, grafted tissues displayed a confluent endothelial layer overlaying the medial layer in which BM-SMPC were aligned circumferentially and synthesized significant amounts of collagen. In contrast to previous results with vascular SMC, BM-SMPC synthesized high amounts of elastin that was organized in a fibrillar network very similar to that of native vessels. Conclusions Our results suggest that BM-SMPC may be useful in studying SMC differentiation and have high potential for development of cell therapies for the treatment of cardiovascular disease.
Changing configurations of power in North-South Relations since 1945

The demand by Third World countries for a “new international economic order” also has its political dimension. Do the threats of commodity cartels, debt defaults, and investment expropriation reflect a fundamental shift in the balance of power between North and South? This paper argues, to the contrary, that the power of the South is quite limited. An analysis of trade, financing, and investment relations between North and South reveals the latter's clearly subordinate position, which is all the more weakened by the fragile political-administrative structures of many Third World regimes. Nevertheless, the demands being made should in some form be accommodated since they serve Northern interests in two important respects: they potentially allow the North new means of leverage in relations with the South; and they offer the North the opportunity to coordinate its various policies and interests in regard to the Third World. Had the South not called for a new international economic order, the North should have pressed for one.
Cost Utility of the Multichannel Cochlear Implant in 258 Profoundly Deaf Individuals

Cost utility analysis is a method of cost-effectiveness analysis which provides results in terms of cost per quality-adjusted life-year (QALY). Cost utility for the multichannel cochlear implant was calculated using Ontario Health Utilities Index data from 229 Nucleus 22-channel implant users and 32 cochlear implant candidates awaiting surgery. The health utility of the implanted group was greater than that of the candidate group by 0.204 (P<.0001). Use of this figure in a cost utility calculation indicates that cochlear implantation costs approximately $15,928 per QALY provided. Sensitivity analysis, a technique which systematically varies the assumptions underlying the calculations, suggests a range for the true value of between $12,000 and $30,000. This compares very favorably with other medical interventions. It is concluded that profound hearing loss has a significant effect on quality of life, and measurement of the changes that result from cochlear implant use indicates that this technology provides significant improvements and is quite cost-effective.
Demonstration of IgE and IgG antibodies against venoms in the blood of victims of fatal sting anaphylaxis

Nine people died from insect sting anaphylaxis in North Carolina from 1979 to 1981. Postmortem blood specimens from eight of these subjects were analyzed for IgE and IgG antibodies against venoms. All eight were RAST positive to at least one of the venoms. IgE and IgG anti-venom levels were comparable to those of a group of untreated sting-allergic individuals. RAST to venoms was also performed on several control groups of sera and from 3% to 50% positive RAST results were found. The highest incidence was in rural North Carolina outdoor workers. The incidence of positive RAST results in the sting-death group was significantly different from that in the control groups. This is the first demonstration of IgE antibodies against venoms in the sera of victims of fatal anaphylaxis from stings and adds further evidence for the role of IgE in sting anaphylaxis.
Ecto-protein kinases and phosphatases: an emerging field for translational medicine

Progress in translational research has led to effective new treatments of a large number of diseases. Despite this progress, diseases including cancer and cardiovascular disorders still are at the top in death statistics and disorders such as osteoporosis and osteoarthritis represent an increasing disease burden in the aging population. Novel strategies in research are needed more than ever to overcome such diseases. The growing field of extracellular protein phosphorylation provides excellent opportunities to make major discoveries of disease mechanisms that can lead to novel therapies. Reversible phosphorylation/dephosphorylation of sites in the extracellular domains of matrix, cell-surface and trans-membrane proteins is emerging as a critical regulatory mechanism in health and disease. Moreover, a new concept is emerging from studies of extracellular protein phosphorylation: in cells where ATP is stored within secretory vesicles and released by exocytosis upon cell-stimulation, phosphorylation of extracellular proteins can operate as a messenger operating uniquely in signaling pathways responsible for long-term cellular adaptation. Here, we highlight new concepts that arise from this research, and discuss translation of the findings into clinical applications such as development of diagnostic disease markers and next-generation drugs.
Advances in High-Resolution X-ray Spectrometry

Some recent advances in technique and interpretation in high-resolution, precision X-ray spectrometry are reviewed. Topics discussed include improvements in X-ray generation and detection systems, the “thickness effect” in X-ray absorption measurements, temporal changes in the spectremetric properties of analyzing crystals, and computational techniques for correcting spectra for instrumental resolving power and for the effects of inner electron states. Applications of these advances to the investigation of the electron energy band structure of solids, to studies of crystal perfection, and to the establishment of precision X-ray wavelength scales are also discussed.
The association of race/ethnicity and risk of atypical femur fracture among older women receiving oral bisphosphonate therapy.

Abstract Purpose Several epidemiologic studies suggest that compared to white women, Asians have a greater propensity to suffer an atypical femur fracture (AFF) while taking bisphosphonate therapy. This study examines the relative risk of AFF following bisphosphonate initiation for Asian compared to white women. Methods Using data from a large integrated northern California healthcare delivery system, we examined diaphyseal femur fracture outcomes among women age ≥ 50 years old who initiated oral bisphosphonate therapy during 2002–2007. An AFF was defined by the 2013 American Society of Bone and Mineral Research Task Force criteria. The risk of radiographically-confirmed AFF was examined for Asian compared to white women, adjusting for differences in bisphosphonate exposure and other potential risk factors. Results Among 48,390 women (65.3% white, 17.1% Asian) who newly initiated bisphosphonate therapy and were followed for a median of 7.7 years, 68 women experienced an AFF. The rate of AFF was 18.7 per 100,000 person-years overall and eight-fold higher among Asian compared to white women (64.2 versus 7.6 per 100,000 person-years). Asians were also more likely to have longer bisphosphonate treatment duration compared to whites (median 3.8 versus 2.7 years). The age-adjusted relative hazard for AFF was 8.5 (95% confidence interval 4.9–14.9) comparing Asian to white women, and was only modestly reduced to 6.6 (3.7–11.5) after adjusting for bisphosphonate duration and current use. Conclusions Our study confirms marked racial disparity in AFF risk that should be further investigated, particularly the mechanisms accounting for this difference. These findings also underscore the need to further examine the association of bisphosphonate duration and AFF in women of Asian race, as well as differential risk across Asian subgroups. In the interim, counseling of Asian women about osteoporosis drug continuation should include consideration of their potentially higher AFF risk.
A CLUSTER OF HODGKIN'S DISEASE IN A SMALL COMMUNITY EVIDENCE FOR ENVIRONMENTAL FACTORS

A cluster of Hodgkin's disease (HD) cases occurred in a small rural town of 1250 people. Ten cases of HD and three cases of non-Hodgkin's lymphoma were identified within or linked to this town since 1954. This town therefore had an average annual incidence and mortality for HD of 29.3 and 16.7 cases per 100,000 population, respectively. Most cases of HD demonstrated case-contact associations, and a distinct geographic distribution. The data suggested that there was an environmental agent responsible for the elevated rates of HD. One unique aspect of this cluster is that this town has only one industry, a large grain elevator. The cases closely surrounded this elevator. We postulate that residents of the town are subject to chronic immune stimulation from mitogenic substances in this environment. These agents may alter immunity in the residents of this community and predispose them to acquiring HD.
Sociology and Age

A distinguished sociologist, writing in this journal recently (Dorn busch, 1971), concluded a plea to his colleagues to beware of the pit falls of mission-oriented and applied research with the following words: ". . .social scientists will do well to remind themselves that their major contribution to their society, their pocketbooks, their students, and their social goals will most likely come via the route of development of their discipline." This writer heartily concurs. Nowhere are these words more germane than in regard to the sociological study of the aging process and old age. For many who refer to themselves as geron tologists, or social gerontologists, are inspired by the application of knowledge to the problems and needs of the elderly. In addition to a strong applied component, the relatively new discipline of gerontology has diverse sources, having risen to its current stature through the interest and concern of scholars and students in all of the social sciences, social work, medicine, and a number of the natural sciences. Hence, most characterize this field as inter disciplinary, although some refer to the study of aging as being a mature field in itself, no longer in thrall to the older areas of knowledge which nurtured it. The remarks which follow stem from the belief that social geron tologists at present will not contribute significantly to the amelioration of the condition of the aged because social gerontology is in point of fact neither a methodologically nor a theoretically developed discipline. Nor does the field have a set of problematics for research (beyond its mission orientation) independent of those of the disciplines from which it is formed. Since the lack of success of "disengagement theory," no coherent general statement or model of the processes and problems to be studied by social gerontologists has emerged. The best hope of increasing our knowledge would seem to be reincorporating the study of age into the parent disciplines with renewed vigor. Indeed, one
Investigation and analysis of the skin test of cephalosporins in hospitals from some areas in China

Objective To investigate and analysis of the skin test of cephalosporins was carried out in 32 hospitals from some areas in China,thus providing some strategies for standardizing operations of the skin test.Methods A single-page survey was carried out to investigate the situation of the skin test of cephalosporins.Results In the investigated hospitals,56.2% hospitals requested skin test for all the patients using cephalosporins while 40.4% hospitals only for ones being allergic to penicillin.In the different wards,the original drugs were used as the source of skin test in 69.7% wards,the penicillin in 12.0% wards.There was a certain difference between the solution concentration and volume.The positive rate of skin test was about 5%～10%.Conclusion To strengthen the clinical medication safety,the skin test of cephalosporins,including operational processes,should be standardized by relevant state departments.
Integrated Dual Disorder Treatment Implementation in a Large State Sample.

Individuals with co-occurring illnesses are at risk for poor outcomes related to criminal justice, hospitalization, housing, and employment. High fidelity evidence-based models, including integrated dual disorder treatment (IDDT), are associated with significant outcome improvements. A descriptive analysis of secondary datasets including the full sample of IDDT fidelity reviews completed from 2006 to 2012 in one state was completed. Total IDDT fidelity significantly improved from baseline fidelity review (68) to second review (40) [t(38) = 35.00, p < .001], and from second review to third review (13) [t(12) = 22.60, p < .001], with adequate inner-rater reliability by the second review. Individual items that were lower across reviews included practice penetration and family interventions, and higher individual items included multi-disciplinary team, integrated treatment specialist, and time-unlimited services, and treatment measures are higher than organizational measures in baseline and subsequent reviews. In this large state-wide sample, IDDT took time to implement, and improved fidelity occurred from baseline to third review, and variance between components of the practice was significant.
OpenMeasure: Adaptive flow measurement & inference with online learning in SDN

Accurate and efficient network-wide traffic measurement is crucial for network management. Recently, Software-defined networking (SDN) has opened up new opportunities in network measurement and inference. In this work, we demonstrate an efficient flow measurement and inference framework which performs adaptive measurement with online learning. Using the reprogrammability of SDN, we assist network inference with online learning predictions and dynamically update the measurement rules network-wide to track and measure the most informative flows. To best utilize the available measurement resources, we leverage the SDN controller (with its global view) to optimally place flow monitoring rules across network switches. Using real-world data, we show that our measurement framework achieves high performance in both estimating the traffic matrix and identifying hierarchical heavy hitters.
Influence of Curing Regimen on the Distortion of a Work-piece held by a Hybrid PAAW Fixture

Abstract The formation of adhesive joints between a work-piece and grippers provides an effective means of stiffening compliant work-piece regions. However if the grippers are anchored in the fixture, the residual stresses that result from adhesive shrinkage can significantly distort the work-piece regions they are intended to support. This research shows that distortion is heavily influenced by curing regimen. When adhesive joints are cured sequentially, the order in which adhesive joints are cured can be manipulated to minimize the distortion at various regions as well as minimize the maximum distortion for the overall region. Curing order also heavily influences the residual forces in the adhesive joints while simultaneously not affecting system compliance. Curing the adhesive joints simultaneously neither leads to the maximum distortion for a system nor the minimum.
Distal Interphalangeal Joint Arthrodesis Complicated by Postoperative Infection: A Rare Presentation of Disseminated Herpes Simplex Virus

Postoperative infection after elective arthrodesis of the interphalangeal joint is an uncommon complication often necessitating urgent debridement. We present the rare case of a female patient with a history of oral herpetic lesions, who underwent elective arthrodesis of the middle and index fingers for treatment of erosive osteoarthritis and subsequently developed a postoperative herpetic infection at the surgical site.
The Th2 gene cluster unraveled: role of RHS6.

Although the transcription factors that regulate T helper (Th) type 2 cytokine production (IL-4, IL-5, and IL-13) are possible novel therapeutic targets, we lack a detailed understanding of the mechanisms that regulate the transcription of these cytokines. In this issue of Allergy, Hwang et al. studied the role of a specific DNA region (a cis-acting element called Rad50 hypersensitive site 6) RHS6, in the development of allergic airway inflammation. RHS6 is found in the Th2 cytokine “locus control region” but its role in activation of the IL-4, IL-5, and IL-13 genes was unknown. The authors here showed that RHS6 recruited the transcription factors GATA3, SATB1, and IRF4, each of which are involved in transcription of all three Th2 cytokine genes. Indeed genetic deficiency in RHS6 inhibited expression of IL-4, IL-5, and IL-13 and reduced allergic airway inflammation in a murine model of ovalbumin-induced sensitization. Deletion of RHS6 also inhibited formation of the transcription factor complex of GATA3, SATB1, and IRF4 that reduced the transcription of IL-4, IL-5, and IL-13. This study suggests that RHS6 is critical for the development of allergic airway inflammation and that the GATA3, SATB1, IRF4 and RHS6 complex maybe a potential therapeutic target for the treatment of asthma. This article is protected by copyright. All rights reserved.
Effect of defective ERCC2 on cisplatin and ionizing radiation (IR) sensitivity in bladder cancer cells.

333Background: Genetic alterations within ERCC2 correlate with extraordinary responses to neoadjuvant cisplatin-based chemotherapy and bladder-sparing ionizing radiation (IR) in muscle-invasive bladder cancer (MIBC). Two studies correlated ERCC2 mutations with pathologic response to chemotherapy and improved disease-free and bladder intact survival following trimodality therapy. We sought to characterize the biological significance of these mutations in bladder cancer cells using CRISPR/Cas9-mediated ablation of ERCC2 function. Methods: The ERCC2 T484A/M point mutation was the most common alteration (4 of 36 patients) within a prospectively collected cohort of 299 bladder cancer patients sequenced at our institution. We infected the ERCC2 wild-type KU19-19 bladder cancer cell line with a CRISPR/Cas9 lentivirus targeting residues 481-487 of ERCC2 and identified a cell clone harboring an ERCC2 in-frame deletion (M483_T484del). Following exposure to cisplatin and IR, cell viability was examined using Cell-ti...
Large-scale isolation of nuclear membranes from bovine liver.

Publisher Summary This chapter describes the procedure for the isolation of nuclear membranes from bovine liver which is the largest preparation reported to date, making it extremely useful for nuclear membrane fractionation studies. The size of the preparation can be scaled up or down according to the needs and facilities available. A beef liver weighing 10–15 pounds is obtained within an hour after removal from the animal. Excess blood is removed by washing with 0.25 M sucrose TKM. The surrounding membrane is then peeled from the surface of the liver. Crude nuclei pellets are isolated by differential centrifugation using the 4-liter capacity swinging-bucket rotor of the International PR-2 Centrifuge at 800 g for 20 minutes. Nuclei are purified by centrifuging through a dense sucrose solution. The crude nuclear pellets are resuspended in 2.3 M sucrose TKM by vigorously shaking, and filtered through 8 layers of cheese cloth. The nuclear preparation was analyzed by light, Nomarski interference, and electron microscopy. Nuclear pore complexes are an excellent ultrastructural marker for identifying nuclear membranes, if the membranes are isolated in an intact enough state to demonstrate pore complexes.
Mycorrhizal Status of Pines in Nurseries

Mycorrhizal status, soil and foliar nutrient status, and production histories were determined for Japanese black pine (Pinus thunbergiana Franco.) and dwarf Mugo pine (Pinus mugo Turra ‘mugo’) in 4 Long Island, New York nurseries. All pines sampled were mycorrhizal. No significant effect of age on percentage mycorrhizal roots was observed between 2-,3- and 5-year-old Japanese black pine. The extent of mycorrhizal formation with Mugo pine could not be correlated with differences in soil or foliar nutrient status among 3 field nurseries. However, field grown Mugo pine had approximately 20% more mycorrhizal roots (70%) than container grown plants (50%). A controlled greenhouse study of Mugo pine inoculated with the ectomycorrhizal fungus Pisolithus tinctorius (Pers. Coker and Couch) showed decreased mycorrhizal levels with increased N, suggesting that differences in mycorrhizal intensity between field and container grown nursery stock may have been related to differences in fertility.
Improving Drug Safety

Spontaneous reporting systems (SRS) as a form of post-market drug-safety passive surveillance were created several decades ago. SRS do have several limitations. Somewhat common but serious events will not necessarily prompt the filing of a report. Reporting is voluntary, leading to under-reporting of adverse events, and submitted reports are often lacking in detail. Post-market active drug-safety surveillance is now emerging as a realistic and powerful complement to SRS. Recent examples of active surveillance systems are presented in this paper; these have some, but not all, the elements of an ideal active surveillance programme.
Policy preferences in a post-war environment:

Can reminders of violence committed in the past influence citizens’ policy preferences in the present? Prior work has found that under the threat of violence individuals prioritize safety and adopt...
A Template for Parallelizing the Louvain Method for Modularity Maximization

Detecting communities using modularity maximization is an important operation in network analysis. As the size of the networks increase to petascales, it is important to design parallel algorithms to handle the large-scale data. In this chapter, a shared memory (OpenMP-based) implementation of the Louvain method, one of the most popular algorithms for maximizing modularity, is introduced. This chapter also discusses the challenges in parallelizing this algorithm as well as metrics for evaluating the correctness of the results. The results demonstrate that the implementation is highly scalable. Moreover, it also focuses on how this template can be extended to time-varying networks.
Posteromedial Release for Clubfoot

The patient is positioned prone. The leg was elevated and exsanguinated with the use of an Esmarch and tourniquet inflated to 220 mmHg. A posteromedial incision was made. Dissection was carried down through subcutaneous tissues and the neurovascular bundle was identified and dissected along its course and gently retracted with a vessel loop. The posterior tibial, FDL, and FHL tendons were identified and retracted. The tendon Achilles was then identified. The sheath was opened and the achilles tendon was subsequently divided in a Z-lengthening fashion. The posterior ankle capsule was identified and cleared of both posteromedial and posterolateral structures. The neurovascular bundle and tendons were protected while the capsule was incised into the tibiotalar and subtalar joints.
The Feminist Question in Realism

Feminist standpoint theory and critical realism both offer resources to sociologists interested in making arguments that account for causal complexity and epistemic distortion. However, the impasse...
Refractory In-Stent Restenosis: Improving Outcomes by Standardizing Our Approach

This review will focus on our approach for the treatment of refractory in-stent restenosis. The discovery of bare metal stents over three decades ago set a milestone in the evolution of percutaneous coronary intervention, which is currently the most widely performed procedure for the treatment of symptomatic coronary disease. However, the broad utilization of stents resulted in the new phenomenon of in-stent restenosis (ISR). Over the years, there has been an increase of the incidence of ISR despite continued improvement of drug-eluting stent (DES) technology. The mechanism of ISR is multifactorial, including biological, mechanical, patient, and operator-related factors. The most common factor is aggressive neointimal proliferation and neoatherosclerosis. ISR presentation is not benign, and treatment is challenging, especially in cases of DES-ISR. We review available therapy modalities for ISR, including medical therapy, scoring balloons, atheroablative therapies, repeat DES, vascular brachytherapy, drug-coated balloons, and coronary artery bypass grafting.
Cyclic and Linear Polyhydroxylbutyrates from Ring-Opening Polymerization of β-Butyrolactone with Amido-Oxazolinate Zinc Catalysts

A series of amido-oxazolinate zinc complexes have been employed for the ring-opening polymerization of rac-β-butyrolactone (BBL). Experimental results show that these complexes efficiently catalyze...
Nodal Dynamics after In Vivo Rescue of βIV Spectrin Expression.

Precise localization of voltage-gated sodium channels (Nav) at nodes of Ranvier is required for efficient signal transmission along myelinated axons. By restricting Nav to gaps in the myelin sheath, the nodal complex focuses the regeneration of action potentials to discrete sites and ensures
Adipose-derived stem cell extracellular vesicles: A systematic review✰.

Summary Introduction Extracellular vesicles (EVs) are cell-secreted packages that deliver cargo to target cells to effect functional and phenotypic changes. They are secreted by many different cell types, including adipose-derived stem cells (ADSCs), which are a promising field of study in regenerative medicine. Our aim was to perform a systematic review of the literature to summarize the scientific work that has been conducted on ADSC EVs to date. Methods The Pubmed database was queried with keywords (and variations of) “adipose derived stem cell,” “stromal vascular fraction,” and “extracellular vesicles.” We excluded review papers, then manually screened articles based on title and abstract. Full-text articles were assessed for eligibility to include in final review. Results While an extensive body of research exists on EVs, a much smaller proportion of that is original research on ADSC EVs. Of 44 manuscripts that met our database search criteria, 21 articles were selected for our systematic review. Conclusion ADSC EVs were found to exert effects on angiogenesis, cell survival and apoptosis, inflammation, tissue regeneration, and reduction of disease pathology. Further studies examine characteristics of ADSC EVs. Future work should aim to further detail the safety profiles of ADSC EVs given their potential for cell-based therapies. The body of research studies characterizing ADSC EVs continues to expand, and much work remains to be done before human pilot studies can be considered. To our knowledge, we offer the first systematic review summarizing the research on ADSC EVs and their determined roles to date.
Incorporating the Portable Operant Research and Teaching Laboratory into Undergraduate Introduction to Behavior Analysis Courses

The use of operant chambers for research and teaching in behavior analysis is in decline due to the expense, maintenance, and ethical considerations of such complex mechanical apparati (Venneman and Knowles in Teach Psychol 32(1):66–68, 2005. https://doi.org/10.1207/s15328023top3201_13). Other technologies for testing and demonstrating behavioral principles have emerged in the pursuit of creating free operant paradigms that are accessible and effective for students and economical for institutions. One example is virtual programs that emulate the behavior of organisms such as CyberRat and Sniffy (Graham et al. in Behav Res Methods Instrum Comput 26(2):134–141, 1994. https://doi.org/10.3758/bf03204606; Ray in CyberRat (version 1.0), Brown & Benchmark, Madison, 1996; Behav Philos 39:203–301, 2011). Recently, a new instrument has been developed—the Portable Operant Research and Teaching Lab (PORTL; Rosales-Ruiz and Hunter in Operants 4:34–36, 2016). PORTL is a tabletop apparatus comprised of various objects and tools that enable students to experience and manage free operant situations. In addition to its instructional benefits, PORTL provides a setting for basic research to be completed quickly and ethically with human participants. The purpose of this paper is to outline how to incorporate PORTL into undergraduate behavior analysis courses. Several examples of how PORTL has been incorporated into such courses, including sample exercises, are provided as a model for other course instructors.
Improving patients' ability to identify their physicians through the use of physician facecards and whiteboards.

Background Hospitalised patients are often not able to correctly identify members of their physician team. Identifying physicians is a critical component of developing the patient–physician relationship and visual aids have been shown to improve physician identification and overall patient satisfaction. Objectives The aim of this quality improvement study was to assess the impact of implementation of a physician facecard on the ability of patients to identify their attending physician and other members of the physician team, as well as to evaluate current use of patient whiteboards for physician team identification. Methods We prospectively studied 149 patients admitted to the medicine teaching service, who were randomised to receive a physician facecard or usual care. Patients were surveyed to determine their ability to identify physician team members. Observational data was also collected regarding use of patient whiteboards. Additionally, all hospitalists were surveyed to assess their perception of these visual aids. Results Patients who received the facecard were more likely to recall the name of the attending physician as compared with the control group (63% vs 32%, p Conclusion The use of physician facecards improves the ability of hospitalised patients to identify their attending physicians, and the combined use of facecards and whiteboards may provide additive benefits.
Development of Sealed Tube Microchannel Plate Detectors with Cross Strip Readouts

Cross strip readout anodes provide a novel high spatial resolution image encoding system for microchannel plate sensors. We have developed cross strip readouts with metal & ceramic layers for 50 mm format sealed tubes based on the "Planacon" concept. These have next generation atomic layer deposited microchannel plates for amplification and selected photocathodes covering the UV and optical regimes. These devices will be relevant for the next generation of moderate and large NASA astrophysics instruments that are baselining 50 mm to 200 mm format detectors. The critical elements of the sensors are high QE, high spatial resolution and large event rate limits, with long lifetimes. Our photocathode work includes customization of bialkali semitransparent cathodes with response from 120 nm to 320 nm and a sharp 360 nm cutoff. Opaque alkali halide photocathodes on the atomic layer deposited microchannel plates have shown high quantum efficiencies (50% @ 115 nm) and could be used simultaneously with bialkali photocathodes. The atomic layer deposited microchannel plates have borosilicate substrates which are robust and can be be produced in large formats (20 × 20 cm) with high open area ratios (~73%). These MCPs have very low intrinsic background (<0.06 events/sec/cm2), high gain, and very good lifetime stability. With the cross strip readout and encoding electronics we achieve high spatial resolutions (<20 µm FWHM) over both 50 mm and 100 mm formats at event rates exceeding 5 MHz, providing a powerful baseline for future NASA UV/optical instruments.
Tracking Mesoscale Convective Systems that are Potential Candidates for Tropical Cyclogenesis

AbstractThis study introduces the development of the Tracking Algorithm for Mesoscale Convective Systems (TAMS), an algorithm that allows for the identifying, tracking, classifying, and assigning o...
Becoming coaches: A study of two novices’ journey

Abstract This paper examines the practice of two novice teacher educators working as instructional coaches in a university-based teacher education program. Previous research suggests that the knowledge and skills required to be an effective teacher are distinct from those required to be an effective teacher educator. Yet novice teacher educators often receive minimal preparation. This qualitative study identifies dilemmas that novice coaches encounter during observation debrief conversations in order to inform coach training. The findings suggest that the process used by the researchers to surface dilemmas may also be a useful intervention in shaping the identity and practice of novice teacher educators.
Greigite (Fe3S4) is thermodynamically stable: Implications for its terrestrial and planetary occurrence.

Iron sulfide minerals are widespread on Earth and likely in planetary bodies in and beyond our solar system. Using measured enthalpies of formation for three magnetic iron sulfide phases: bulk and nanophase Fe3S4 spinel (greigite), and its high-pressure monoclinic phase, we show that greigite is a stable phase in the Fe–S phase diagram at ambient temperature. The thermodynamic stability and low surface energy of greigite supports the common occurrence of fine-grained Fe3S4 in many anoxic terrestrial settings. The high-pressure monoclinic phase, thermodynamically metastable below about 3 GPa, shows a calculated negative P-T slope for its formation from the spinel. The stability of these three phases suggests their potential existence on Mercury and their magnetism may contribute to its present magnetic field.
Wait and See? Alignment of Organizational Capability, OrganizationalStructure and Managerial Cognition in Technology Adoption

Extant research studies have made many observations about the success or failure of a firm’s technology adoption strategy while facing a new generational technology, but evidence on factors that may drive or hinder firms to adopt such a new technology ex ante is lacking. Drawing upon the literature on technology management, strategic renewal and organizational economics, this paper examines a list of such factors, including competence-destroying, capability gap, reconfiguration costs, integrative capabilities and managerial cognition. Findings based upon a survey sample from the U.S. bio-fuels industry (ethanol sector and bio-diesel sector) show that a firm’s likelihood to adopt a new technology is negatively associated with the extent to which the new technology destroys its current competency, the capability gap between its current capabilities and the targeted capabilities, and the integrative capabilities accumulated through integration of value chain activities around the current technology. Managerial perceptions about the firm’s growth prospect moderate the above relationships by redirecting managerial attention from the focal affected business to other businesses of a firm. Given the importance of new technology development for the bio-fuels industry, and other industries in general, this study provides both managerial and policy implications.
Beyond Testing: Seven Assessments of Students and Schools More Effective than Standardized Tests: D. Meier and M. Knoester. New York: Teachers College Press, 2017. 145 pp. ISBN 978-0-8077-5853-3

Educational assessment and democratic citizenship are terms rarely found in the same sentence, yet, they are closely interrelated. Critics argue that the purpose of educational assessment should be...
What Does Social Justice Look Like in the United States? Critical Reflections of an English Language Classroom on a Field Trip

This article witnesses a field trip of a group of English learners and the instructor at a historical site in the United States of America. The purpose of this trip explores a question, What does “...
Distributed Algorithms for Array Signal Processing

Distributed or decentralized estimation of covariance, and distributed principal component analysis have been introduced and studied in the signal processing community in recent years, and applications in array processing have been indicated in some detail. Inspired by these, this paper provides a detailed development of several distributed algorithms for array processing. New distributed algorithms are proposed for DOA estimation methods like root-MUSIC, total least squares-ESPRIT, and FOCUSS. Other contributions include distributed design of the Capon beamformer from data, and distributed implementation of the spatial smoothing method for coherent sources. A distributed implementation of a recently proposed beamspace method called the convolutional beamspace (CBS) is also proposed. The proposed algorithms are fully distributed – an average consensus (AC) is used to avoid the need for a fusion center. The algorithms are based on a recently reported finite-time version of AC which converges to the exact solution in a finite number of iterations. Numerical examples are given throughout the paper to show the effectiveness of the proposed algorithms.
An Unthinkable Politics for Multispecies Flourishing within and beyond Colonial-Capitalist Ruins

Colonial-capitalist animal agriculture is a site of ruin and a process of ruination. Farmed animals at the heart of these agricultural systems become sites of production and capital accumulation, t...
Neural Correlates of Human Attachment: Evidence from fMRI Studies of Adult Pair-Bonding

According to some researchers romantic relationships (or pair-bonds) are the adult instantiation of attachment in childhood. This chapter reviews research on the neural correlates of early-stage, newlywed, and long-term pair-bonds highlighting how the dopamine reward system (implicated in motivation and goal-directed actions) mediates their formation, establishment, and maintenance. I also discuss activation of serotonin, vasopressin and opioid rich regions of the raphe and ventral pallidum found among newlyweds and long-term pair-bonds as reflecting the emergence of attachment in adults. Similarly, I discuss results on the association of relationship length with brain activity to further elucidate markers for pair-bond solidification. Finally, I review key sites common for pair-bonds and parent-child bonds as reflecting attachment in areas associated with reward, goal-directed actions, calm, homeostasis, and attention. Collectively, these results highlight how the brain mediates attachment processes (e.g., proximity-seeking, felt security, and responsiveness) that are critical for the solidification and maintenance of pair-bonds, and the evolutionary success of the species.
Inhomogeneity study of alanine and valine-doped TGS crystal using micro-probe Raman spectroscopy

Micro-probe Raman spectroscopy is used for studying positional inhomogeneity in alanine-doped TGS crystals. 20 data points are measured along the c- and a-axes in b-plane. Several known Raman peaks are observed unchanged, but most other peaks are found to be changed remarkably. The major difference in spectra are found to be related to SO/sub 4/ vibrations. The vibrational frequencies are found to be lowered near the seed position. The most unstable spectra are detected in the vicinity of the seed region.
Reliability of multidimensional substance abuse treatment matching: implementing the ASAM Patient Placement Criteria.

For meaningful adoption, the Patient Placement Criteria (PPC) of the American Society of Addiction Medicine (ASAM) will need adequate interrater reliability. In a decision analysis of the original PPC, we reduced potential sources of unreliability, mapped question items from clinical research instruments to each decision point, and programmed the item map as a computerized structured interview. Then, target videotapes from eight substance dependent adults who had been distributed by the algorithm into three levels of care (LOC) were independently scored by four raters who were blind as to ASAM LOC. The intraclass correlation coefficient for ASAM LOC assignment was .77. For all but two subscales of component instruments, values were above .70 and significant, indicating high interrater reliability. With these methods, excellent reliability is possible for complex decision trees, making it possible to improve the validity of the ASAM Criteria and similar complex hierarchical clinical protocols.