cssi/SciSciGPT-SciSciNet huggingface dataset:
Reducing Work-Life Conflict in Information Technology Professions: The Effects of Mentoring, Interest, and Self-Efficacy

This paper examines the relationship between mentoring and work-life balance in the IT field. Interest is found to serve as a moderator between mentoring and self efficacy, offering a link between the two constructs that prior literature has not established. A model is tested to determine the indirect effects of promotional mentoring, through interest and self efficacy, on work-life balance issues. It was determined that promotional mentoring improved students' self efficacy when students expressed interest in the field. This increased self efficacy mitigated perceived work-family conflict. These findings offer implications for mentoring in IT education. This paper also offers insights in the retention and recruiting purposes in the IT profession, where work-life balance issues often have a major impact on the longevity of employees' careers.
Interleukin‐2 Can Cure Kidney Cancer

As new immunotherapy treatment options become available, one must focus on the goals of extending survival and of potential cure.
Stress incontinence surgery at the time of prolapse surgery: Mandatory or forbidden?

Introduction Concomitant anti-incontinence surgery at the time of prolapse repair has been a long-debated topic. Still today, there remains no clear answer to this question, although in recent years the literature has become more robust with the addition of more randomized controlled trials. The lifetime risk for women of undergoing surgical correction of pelvic organ prolapse is significant, and concomitant anti-incontinence surgery is an important question during surgical planning.
Effects of comorbidity burden and age on brain integrity in HIV.

Author(s): Saloner, Rowan; Heaton, Robert K; Campbell, Laura M; Chen, Anna; Franklin, Donald; Ellis, Ronald J; Collier, Ann C; Marra, Christina; Clifford, David B; Gelman, Benjamin; Sacktor, Ned; Morgello, Susan; McCutchan, J Allen; Letendre, Scott; Grant, Igor; Fennema-Notestine, Christine; CHARTER Study Group | Abstract: ObjectiveThe influence of confounding neurocognitive comorbidities in people living with HIV (PLWH) on neuroimaging has not been systematically evaluated. We determined associations between comorbidity burden and brain integrity and examined the moderating effect of age on these relationships.DesignObservational, cross-sectional substudy of the CNS HIV Antiretroviral Therapy Effects Research cohort.MethodsA total of 288 PLWH (mean age = 44.2) underwent structural MRI and magnetic resonance spectroscopy as well as neurocognitive and neuromedical assessments. Consistent with Frascati criteria for HIV-associated neurocognitive disorders (HAND), neuromedical and neuropsychiatric comorbidity burden was classified as incidental (mild), contributing (moderate), or confounding (severe-exclusionary) to a diagnosis of HAND. Multiple regression modeling predicted neuroimaging outcomes as a function of comorbidity classification, age, and their interaction.ResultsComorbidity classifications were 176 incidental, 77 contributing, and 35 confounded; groups did not differ in HIV disease characteristics. Relative to incidental and contributing participants, confounded participants had less cortical gray matter and more abnormal white matter and ventricular cerebrospinal fluid, alongside more neuroinflammation (choline, myo-inositol) and less neuronal integrity (N-acetylaspartate). Older age exacerbated the impact of comorbidity burden: to a greater extent in the confounded group, older age was associated with more abnormal white matter (P = 0.017), less total white matter (P = 0.015), and less subcortical gray matter (P = 0.014).ConclusionNeuroimaging in PLWH reveals signatures associated with confounding neurocognitive conditions, emphasizing the importance of evaluating these among individuals with suspected HAND. Older age amplifies subcortical and white matter tissue injury, especially in PLWH with severe comorbidity burden, warranting increased attention to this population as it ages.
Altered mental status in alcoholism.

Dr. Mark Sagarin: Today’s case is that of a 56-year-old man with alcoholism who presented with tremor and confusion. He reported feeling poorly for 1 week with subjective fever, cough productive of yellow sputum, decreased appetite, and decreased urine output. The past medical history was notable for a transient ischemic attack 1-year previously, alcohol abuse, and smoking. He took no medications regularly and had no drug allergies. He consumed approximately five quarts of beer and one package of cigarettes each day. He was homeless. He denied drug use or unprotected sexual activity. Dr. David Brown: Are there any questions about the patient’s initial presentation? Dr. Ted Benzer: Could he tell you when his last drink was, and was there any recent history of trauma? Dr. Sagarin: His last alcoholic beverage was 2 to 3 days previously, and he thought it was possible he had fallen and had struck his head but could not say definitively. Dr. Stephen Thomas: Did he arrive in the Emergency Department (ED) by ambulance? If so, can you describe his prehospital course? Dr. Sagarin: He was found seated on a park bench, slightly confused, by a bystander who activated 911. Prehospital providers found him alert but tremulous. Prehospital vital signs were: systolic blood pressure 140 mmHg, heart rate 115 beats/min, respiratory rate 20 breaths/min, oxygen saturation 93% on room air. Paramedics administered oxygen by 100% facemask, which increased his saturation to 99%. Blood sugar was 100 mg/dL. One 18-gauge intravenous (i.v.) line was established and thiamine 100 mg i.v. was administered. He was transported rapidly to the ED. On physical examination, he was alert but slightly confused. Vital signs were: temperature 40.3°C, blood pressure 133/81 mmHg, heart rate 120 beats/min, respiratory rate 20 breaths/min, oxygen saturation 93% on room air. Skin examination was normal. Cranial examination revealed no deformities or scalp lacerations. Tympanic membranes were obscured by impacted cerumen. Nasopharyngeal, midface, and mandibular examinations were unremarkable. Oral mucous membranes were dry. There was a small amount of dried blood on the anterior tongue and lower incisors. There was poor dentition but no dental injury. The neck was supple without jugular venous distension. There were no carotid bruits, enlarged nodes, or thyromegaly. Lung auscultation revealed diffuse crackles in the right lung field. Cardiac examination revealed a rapid, regular rhythm with no murmurs, rubs, or gallops. The abdomen was soft, nontender, nondistended, with no rebound, guarding, or masses. The rectum was nontender with soft heme-negative stool in the vault. Prostate examination was normal. Extremity examination revealed no cyanosis, clubbing or edema, and 21 pulses throughout. The patient was anxious, alert, and oriented to name, hospital, and season. He could not recall the date or United States president’s name. He had a slight resting tremor. His strength was 5/5 throughout,
Lending a hand for laparoscopic distal pancreatectomy: the optimal approach?

Abstract Background Both minimally invasive surgery (MIS) and open approaches for distal pancreatectomy are acceptable. MIS options include total laparoscopic/robotic (TLR) and hand-assist laparoscopy (HAL). When considering safety profile and specimen quality, the optimal approach is unknown. Methods Patients who underwent distal pancreatectomy from 2010-2018 at two major academic institutions were included. Converted procedures were categorized into final approach. Ninety-day perioperative/pathologic outcomes of MIS and open were compared. Subset analyses between TLR vs HAL and HAL vs open were performed. Intent-to-treat analysis was performed. Results Among 1006 patients, resection was performed by MIS in 35% (n = 352), open in 65% (n = 654). MIS had similar patient comorbidity profile as open but had increased operative time (183 vs 162 min; p Conclusion Hand-assist laparoscopy is safe and feasible for distal pancreatectomy as operative time, complication profile, lymph node yield, and R0-rates are similar to open procedures, while maintaining the associated the advantages of a total laparoscopic/robotic approach with reduced blood loss and shorter length-of-stay.
Black Women: Then and Now

Social media and traditional resources were used to examine discourse about the role and position of Black women during the civil rights movement of the 60s and the #BlackLivesMatter movement. Disc...
Examining generalization of motorist yielding at an adjacent crosswalk with variations of the gateway sign configuration

The gateway sign configuration has been effective at increasing motorist yielding and reducing speeds at crosswalks. A gateway configuration uses in-street signs at a crosswalk on each edge of the roadway and on each lane line. Although this intervention is effective at increasing motorist yielding at uncontrolled crosswalks, the limits of the intervention have yet to be tested. The present study examined if 1) the effects of the gateway intervention on one crosswalk would generalize to an untreated adjacent crosswalk, and 2) if the effects of an offset configuration of signs which partially treated each crosswalk could maximize the effects of that generalization. Experiment 1 showed that less yielding occurred at the untreated crosswalk than at the treated crosswalk, though yielding was higher than baseline. In Experiment 2, results showed that an offset gateway configuration could produce comparable levels of yielding at both crosswalks.
Successful liver transplantation in a patient recovered from COVID-19.

Transplantation in potential candidates who have recently recovered from COVID-19 is a challenge with uncertainties regarding the diagnosis, multi-organ systemic involvement, prolonged viral shedding in immunocompromised patients, and optimal immunosuppression. A 42 year male with alcoholic hepatitis underwent a successful deceased donor liver transplantation 71 days after the initial diagnosis of COVID-19. At the time of transplant, he was SARS-CoV-2 PCR negative for 24 days and had a MELD score of 33. His post-operative course was complicated by acute rejection which responded to intense immune-suppression using T-cell depletion and steroids. He was discharged with normal end-organ function and no evidence of any active infection including COVID-19. Prospective organ transplant recipients who have recovered from COVID-19 can be considered for transplantation after careful pre-transplant evaluation, donor selection, and individualized risk-benefit analysis.
An integrated multi-omic analysis of iPSC-derived motor neurons from C9ORF72 ALS patients

Summary Neurodegenerative diseases present a challenge for systems biology, due to the lack of reliable animal models and the difficulties in obtaining samples from patients at early stages of disease, when interventions might be most effective. Studying induced pluripotent stem cell (iPSC)-derived neurons could overcome these challenges and dramatically accelerate and broaden therapeutic strategies. Here we undertook a network-based multi-omic characterization of iPSC-derived motor neurons from ALS patients carrying genetically dominant hexanucleotide expansions in C9orf72 to gain a deeper understanding of the relationship between DNA, RNA, epigenetics and protein in the same pool of tissue. ALS motor neurons showed the expected C9orf72-related alterations to specific nucleoporins and production of dipeptide repeats. RNA-seq, ATAC-seq and data-independent acquisition mass-spectrometry (DIA-MS) proteomics were then performed on the same motor neuron cultures. Using integrative computational methods that combined all of the omics, we discovered a number of novel dysregulated pathways including biological adhesion and extracellular matrix organization and disruption in other expected pathways such as RNA splicing and nuclear transport. We tested the relevance of these pathways in vivo in a C9orf72 Drosophila model, analyzing the data to determine which pathways were causing disease phenotypes and which were compensatory. We also confirmed that some pathways are altered in late-stage neurodegeneration by analyzing human postmortem C9 cervical spine data. To validate that these key pathways were integral to the C9 signature, we prepared a separate set of C9orf72 and control motor neuron cultures using a different differentiation protocol and applied the same methods. As expected, there were major overall differences between the differentiation protocols, especially at the level of in individual omics data. However, a number of the core dysregulated pathways remained significant using the integrated multiomic analysis. This new method of analyzing patient specific neural cultures allows the generation of disease-related hypotheses with a small number of patient lines which can be tested in larger cohorts of patients.
Is Ethnonationalism Growing in Ethiopia and Will it Lead to the Dissolution of the Country? Evidence from the World Value Survey 2007–2020:

In this paper, I examine whether ethnopolitical identities have grown in Ethiopia since the introduction of Prime Minister Abiy Ahmed’s reforms in 2018, using the most recent Ethiopian survey data ...
On the Destruction of Primordial Deuterium

Agreement between the predictions of standard big bang nucleosynthesis and the observed abundances of the light elements is achieved for a small range in values of the baryon to photon ratio, η near 3 × 10−10. At that value of η, the primordial deuterium abundance is about 7.5 × 10−5. ISM measurements of D indicate a present abundance 5 times smaller. Chemical evolution models are explored to achieve this degree of D destruction. Consistency with the 3He production in low mass stars and with the abundance of cosmo-chronometers is also discussed.
Comprehensive 2-dimensional gas chromatography fast quadrupole mass spectrometry (GC × GC-qMS) for urinary steroid profiling: Mass spectral characteristics with chemical ionization

Comprehensive 2-dimensional gas chromatography (GC × GC), coupled to either a time of flight mass spectrometry (TOF-MS) or a fast scanning quadrupole MS (qMS) has greatly increased the peak capacity and separation space compared to conventional GC-MS. However, commercial GC × GC-TOFMS systems are not equipped with chemical ionization (CI) and do not provide dominant molecular ions or enable single ion monitoring for maximal sensitivity. A GC × GC-qMS in mass scanning mode was investigated with electron ionization (EI) and positive CI (PCI), using CH4 and NH3 as reagent gases. Compared to EI, PCI-NH3 produced more abundant molecular ions and high mass, structure-specific ions for steroid acetates. Chromatography in two dimensions was optimized with a mixture of 12 endogenous and 3 standard acetylated steroids (SM15-AC) relevant to doping control. Eleven endogenous target steroid acetates were identified in normal urine based on their two retention times, and EI and PCI-NH3 mass spectra; nine of these endogenous target steroid acetates were identified in congenital adrenal hyperplasia (CAH) patients. The difference between the urinary steroids profiles of normal individuals and those from CAH patients can easily be visually distinguished by their GC × GC-qMS chromatograms. We focus here on the comparison and interpretation of the various mass spectra of the targeted endogenous steroids. PCI-NH3 mass spectra were most useful for unambiguous molecular weight determination and for establishing the number of -OH by the losses of one or more acetate groups. We conclude that PCI-NH3 with GC × GC-qMS provides improved peak capacity and pseudomolecular ions with structural specificity. Copyright © 2011 John Wiley & Sons, Ltd.
Nanovid microscopy for assessing sperm membrane changes induced by in vitro capacitating and acrosomal reacting procedures.

: This study was to verify the usefulness of Nanovid microscopy techniques for evaluating induced modifications in bovine spermatozoal membranes. Frozen thawed bovine sperm were labeled with 20-nm colloidal gold particles bound to concanavalin A (ConA) or heparin ligands. Sperm membrane changes were induced in vitro by capacitating and acrosome-reacting procedures. Capacitatton was induced by incubation with 10 μg/ml of heparin for 4 hours at 37°C, 5% CO2, and high humidity. Membrane changes associated with the acrosome reaction were induced by addition of lysophosphatidyicholine (100 μg/ml) and incubation for 15 minutes at 37°C, 5% CO2, and high humidity. Gray intensity (black = 0; white = 255) of sperm (ONCELL) and background (OFFCELL) were evaluated with computer-enhanced videomicroscopy with either differential interference contrast (DIC) or Nanovid optics. A high gold concentration on a membrane region produced blacker video pictures with Nanovid microscopy. Gray intensity of video pictures of a region with little or no gold would have a gray intensity equal to or greater than that of the background, that is, toward white. Weighted least squares methods were used to analyze ONCELL data using OFFCELL as a covariate. In experiment 1, ONCELL intensities of cells labeled with ConA-gold complex were lower than those labeled with heparin-gold at the same treatment level. In experiment 2, ONCELL intensity decreased as the concentration of heparin—gold increased from 0 to 0.041 μg/μl heparin. ONCELL intensity significantly de-creased after sperm were treated with the highest heparin-gold level and acrosome reacted. Differences in ONCELL intensity of acrosome-reacted sperm were smaller in experiment 1 than in experiment 2. Nanovid microscopy techniques resulted in lower ONCELL intensities than did DIC microscopy in both experiments.
Geography of Iridaceae in Africa

Iridaceae, a family of worldwide distribution, comprises some 1 500 species and 85 genera. It exhibits its greatest radiation in Sub-Saharan Africa, where over half the species and some 48 genera occur. 45 of which are endemic. All three major subfamilial taxa are represented in Africa, where Ixioideae are almost entirely restricted, with extensions into Eurasia. Areas of greatest concentration are either montane or in areas of winter rainfall. In southern Africa alone, there are some 850 species in 46 genera, making the family the fifth largest in the flora. In the Cape Floristic Region there are 620 species, and the family is the fourth largest in this area. All major infrafamilial groups occur in the Cape Region where most of the variability as well as generic radiation is encountered. The idea of a southern origin for Iridaceae in Africa is analysed systematically, and is correlated with the major climatic changes that occurred in Africa since the mid-Tertiary, and culminated in the seasonally dry climates along the west coast. The establishment of mediterranean climate in the southwest provided the stimulus for massive speciation and radiation of the family there. Plio-Pleistocene uplift along the eastern half of the African continent led to the establishment of substantial upland areas and allowed the spread of some genera, such as Romulea, Gladiolus, Moraea, and Hesperantha into tropical Africa. Short-distance dispersal probably accounts for the presence of genera such as Gladiolus, Gynandriris and Romulea in Eurasia.
On Control Systems Described by a Class of Linear Differential-Algebraic Equations: State Realizations and Linear Quadratic Optimal Control

Control systems described in terms of a class of linear differential-algebraic equations are introduced. Under appropriate relative degree assumptions, a procedure for obtainig an equivalent state realization is developed using a singular value decomposition. Properties such as stability, controllability, observability, etc. for the differential algebraic system may be studied directly from the state realization. An optimal linear quadratic problem for the differential-algebraic system is aiso studied and results are obtained using the derived state realization. This approach to control of this class of differential-algebraic equations, using a transformation to obtain a state realization, completely avoids the need for any new control theoretic machinery.
Control of nitrogen reactive species in helicon plasmas for III-N semiconductor growth

Summary form only given. Molecular beam epitaxy of III-N materials is potential alternative to MOVPE for fabrication of high quality wide band gap semiconductor devices. However, during the MBE film growth enhancement of nitrogen accommodation and sputtering damage minimization remain as technological hurdles. We report preliminary results on control of reactive nitrogen species performed in a steady state, high density, helicon plasma source CHEWIE (Compact HElicon Waves and Instabilities Experiment). The helicon vacuum chamber is a 12 cm long, Pyrex tube, 6 cm in diameter, connected to a stainless steel diffusion chamber. RF power of up to 1.0 kW over a frequency range of 6-18 MHz is used to create the steady state plasma. A 7 cm long, half wave, m=+1, helical antenna couples the rf energy into the plasma. By a proper selection of the helicon wave phase velocity and input power it is possible to modify the electron velocity distribution function. Thereby increasing the production of molecular excited species, which are favorable to the growth process, and decreasing the production of ionic species, which are detrimental to the epilayer. Further, the expansion of the helicon plasma into the diffusion chamber should permit, through spontaneous radiative relaxation, the different N/sub 2/ triplet excited states to cascade down to the metastable A/sup 3//spl Sigma//sub u//sup +/ state. With a sufficiently long transit time to the expansion chamber, the long lived A/sup 3//spl Sigma//sub u//sup +/ state will become the dominant reactive nitrogen specie in the plasma. Previous optical emission spectroscopy investigations have demonstrated that the N/sub 2/ (B/sup 3//spl Pi//sub g/, v'=11 /spl rarr/A/sup 3//spl Sigma//sub u//sup +/, v"=7 at 580.4 nm) transition, which is a part of the 1st positive system, is the dominant transition in nitrogen helicon generated plasma.
HEMODIALYSIS-ASSOCIATED HEPATITIS: REPORT OF AN EPIDEMIC WITH FURTHER EVIDENCE ON MECHANISMS OF TRANSMISSION

In the period January-September 1974, 50 cases of hepatitis B infection occurred among a nephrology center's hemodialysis patients and staff. The in-center patient population had an attack rate of 96%. Epidemiologic analysis of risk factors for patients revealed an association between the receipt of intravenous medication and the subsequent development of hepatitis, suggesting that parenteral inoculation was a mode of spread among patients (p equals .008). Nineteen per cent of the staff contracted hepatitis, and all of these personnel had had close contact with patients (p equals .005). The prevalence of hepatitis B infection in staff was related to the failure to use gloves (p less than .01), and accidental needle puncture was associated with the development of clinical hepatitis. These data suggested that disease was transmitted to staff by contact with contaminated blood or close personal contact with patients. Additional data showed that the presence of endogenous antibody protected both patients and staff from antigenemia (p equals .002). These data support the hypothesis that contact with blood is the primary mechanism of spread of hepatitis B in dialysis units, and suggest that, as preventive measures, gloves should be used and antibody-positive staff should dialyze antigen-positive patients.
The dependence of hot carrier degradation on AC stress waveforms

The hot carrier degradation of submicron n-channel FETs is characterized for various gate and drain pulse waveforms. The results are consistent with interface electron traps generated by hot holes. The results showed that inverters with small loads can degrade faster than inverters with large loads, due to AC degradation effects. Device lifetime in circuits cannot in general be projected by DC data. The AC effect was also found to be dependent on device structure. >
Optimal Reconfiguration of the Navy Ship Power System using Agents

This paper is a study of the optimization of a configuration and reconfiguration problem applied to the navy ship power system presenting a redundant power distribution layout. The multiagent method has been applied in order to make the power system converge towards its optimal configuration in its initial start up and during normal operation when a reconfiguration is required. The optimal process has been achieved by the agents and the simulations have been conducted with different cases of operation mode of the navy ship. The optimal configurations were derived through a program written in C++ for the agents and the results confirm the feasibility of applying the multiagent method for optimizing the navy ship power system
W Boson production cross section at the Large Hadron cCllider with Omicron(alpha(2)(s)) corrections.

We compute the {Omicron}({alpha}{sub s}{sup 2}) QCD corrections to the fully differential cross-section pp {yields} WX {yields} {ell}{nu}X, retaining all effects from spin correlations. The knowledge of these corrections makes it possible to calculate with high precision the W boson production rate and acceptance at the LHC, subject to realistic cuts on the lepton and missing energy distributions. For certain choices of cuts we find large corrections when going from next-to-leading order (NLO) to next-to-next-to-leading order (NNLO) in perturbation theory. These corrections are significantly larger than those obtained by parton-shower event generators merged with NLO calculations. Our calculation may be used to assess and significantly reduce the QCD uncertainties in the many studies of W boson production planned at the LHC.
NUTRITIONAL STUDIES OF CHILDREN WITH PICA I. Controlled Study Evaluating Nutritional Status, II. Treatment of Pica with Iron Given Intramuscularly

Thirty Negro children with pica were compared nutritionally with 28 control children from the same socioeconomic background. The following findings were statistically significant: lower hemoglobin concentrations, lower levels of ascorbic acid in plasma, less adequate diets, more reported respiratory illness, more recorded days of hospitalization, and more recorded anemia in infancy. No difference was detected between the two groups in clinical evaluation of nutrition or in the number of physical defects. Evidence from anthropometry showed no inferiority in the pica group. Ancillary information indicated that many unfavorable familial and environmental circumstances were also associated with pica, as well as certain behavior disorders of childhood, especially those involving orality. In a double-blind experiment 16 children with pica received suitable doses of iron given intramuscularly, and 16 received similar injections of saline solution. Iron was not significantly more effective than saline solution in curing or improving the habit of pica. There was no correlation between changes in pica and changes in hemoglobin concentration. At 2 to 3 months after the treatment period, 10 treated children and 8 controls were without pica. The improvement in hemoglobin concentration was significantly greater in the treated group, but improvement in pica was approximately the same and highly significant in both groups. At 13 to 27 months after the treatment period, 11 of 14 children remaining in the treated group and 9 of 13 remaining controls were reported to be without pica. There were five severe relapses, two in the treated group and three in the controls, all of which took place in children with initial levels of hemoglobin above 10.5 gm/100 ml. These five children also came from the most seriously disturbed family situations in the whole series. If iron medication is a factor in curing certain cases of pica, the number of such cases in the present series is not sufficient to affect the statistical results.
The measurement of the hydrolysis of solutions of sodium salts of fatty acids. I.

1. pH values of recrystallized samples of sodium acetate, NaAc.3H2O, measured with the Beckman pH meter at 25°C., using the “blue glass” electrode were near pH 8, rather than the calculated and true value for pure sodium acetate of 8.88. Titration curves were made beginning with decinormal solution of the slightly acid salt and adding sodium hydroxide; the pH at the inflection of these curves was near the correct value, 8.8. 2. Sodium hydroxide titration curves in aqueous solution were made at 50°C. for myristic acid and lauric acid, decinormal at the equivalence point. The point of inflection came after the equivalence point, giving the values of hydrolysis alkalinity for these two soaps. 3. Sodium hydroxide titrations in 80% alcohol at room temperature were made in the presence of phenolphthalein for Eastman myristic, Kahlbaum lauric, Lepkovsky myristic and the very pure Francis lauric acid. Concentrations at the equivalence point were about N/60. In every case the equivalence point, the point of inflection, and the color change coincided with the color change occurring near an apparent pH of 10.5 as indicated in alcohol. 4. The solubility of Eastman lauric acid was measured in a number of non-aqueous solvents at temperatures ranging from 23 to 26°C. Solubility was least in a sample of Braun-Knecht-Heimann medicinal mineral oil.
Failure of surgery and isotretinoin to relieve jaw immobilization in fibrodysplasia ossificans progressiva: report of two cases.

Summary Two patients with fibrodyplasia ossificans progressiva who presented with jaw immobilization due to formation of bone between the maxilla and mandible were treated with surgical resection of their ectopic bone in conjunction with experimental, adjunctive medical therapy using isotretinoin. Both patients had recurrence of their ectopic ossification within 2 months of surgery. Surgery to remove joint-bridging ossifications in FOP is not recommended.
New models for exhaustible resource development

Minerals sector firms have joined other industries in going green, and some have used the language of sustainable development in the context of the relationship between industry, environment and community. Because of its historical practices of causing severe land disturbance, water pollution and ecosystem disruption, many have thought the concept of ‘sustainable mining’ an oxymoron. Within the context of trying to find the ‘best’ models for minerals development in the fledgling Russian democracy (specifically in Western Siberia), however, we discovered a number of possibilities for creating at least a more sustainable mining sector. This paper presents in summary form some interim results from our work on sustainable development in the extractive hydrocarbon economies of Western Siberia. We identify practices along three dimensions of sustainability – environment, community and labor – and briefly discuss the implications of these practices for Western Siberia.
Hepatocellular Carcinoma Lesion Characterization: Single-Institution Clinical Performance Review of Multiphase Gadolinium-enhanced MR Imaging—Comparison to Prior Same-Center Results after MR Systems Improvements

Our investigation demonstrated that MR imaging is a highly accurate diagnostic method for the preoperative evaluation of hepatocellular carcinoma (HCC) and that there has been interval improvement in HCC detection sensitivity and characterization for smaller tumors compared with that of our earlier 2004–2006 study.
Micron-particle transport, interactions and deposition in triple lung-airway bifurcations using a novel modeling approach

Abstract Particulate suspensions inhaled by humans are typically dilute and hence interactions between particles can be neglected. In such cases conventional Euler–Lagrange or Euler–Euler methods are suitable to simulate micron- or nano-particle transport and deposition in human respiratory systems. However, when challenging conditions, such as large pressure differentials, high velocity gradients and/or intense particle collisions, exist, alternative approaches for numerical analysis are required to capture fluid–particle, particle–particle, and particle–wall interactions. In the present study, the dense discrete phase model (DDPM) in conjunction with the discrete element method (DEM) have been employed to simulate micron–particle transport, interaction and deposition dynamics in different triple bifurcations (i.e., G3–G6, G6–G9, and G9–G12), using ANSYS Fluent 14.0 enhanced by user-defined functions (UDFs). In light of the relatively high computational cost when employing DDPM–DEM for such simulations throughout the human respiratory system, it may be necessary to combine different computational fluid–particle dynamics (CF–PD) models based on the local intensity of particle–particle interactions. Thus, the validity and necessity of the DDPM–DEM approach for different lung airway generations were numerically investigated, considering new parametric criteria for the use of most suitable numerical models. Specifically, the relative intensities of three major particle deposition mechanisms (i.e., inertial impaction, secondary-flow effect, and particle–particle-interaction impact) in idealized lung-airway segments were investigated. As a result, a new criterion for CF–PD model combination in terms of a relationship between inlet-particle stacking-volume fraction, ϕ, and percentage-of-fate changing particles, Δ β p , is proposed. Visualizations of the fluid–particle dynamics in bifurcating airways have been provided as well. Results of this study pave the way for accurate and cost-effective CF–PD simulations of lung-aerosol dynamics, aiming at the improvement of respiratory dose estimation for health risk assessment in case of toxic particles and for treatment options in case of therapeutic particles.
Pharmacokinetics of intranasally applied medication during a cold

The rate at which interferon is cleared from the nose after local administration was measured in volunteers both before and after challenge with virulent strains of human rhinovirus. Interferon was not cleared more rapidly after virus challenge, and there was no relationship between the amount of nasal secretion produced after challenge, and the rate of interferon clearance. These findings suggest that an inverse relationship between the quantity of a locally applied antirhinovirus drug which is recovered in nasal wash, and clinical and laboratory evidence of rhinovirus infection may be taken as evidence for a beneficial effect of the drug.
Mitotic cells and their microappendages in the primitive streak of the chick embryo.

Fresh pullet eggs (White Leghorn Strain) were incubated to the primitive streak stage of development. Blastoderms were fixed in situ with isotonic aldehyde fixatives and prepared for scanning electron miscroscopy by means of post-osmication, critical point drying and gold-palladium coating. Cells judged to be in various stages of mitosis by their surface contours were numerous on the ventral surface of the chick blastoderm. Cells which were in the late preparatory stages for mitosis had rounded up from their surroundings. Microvilli dominated the surface. The degree of separation and number of microvilli increased until late metaphase or anaphase. Mitotic cells did not completely separate themselves from adjacent cells. Ruffles and blebs were not prominent during mitotis and long filopodia were absent. A definite localization of microappendages (microvilli, blebs, ruffles) to the area of cytokinesis was evident in early telophase and persisted through daughter cell formation.
Pirimiphos-methyl as a Protectant for Stored Inshell Almonds

Sprays of pirimiphos-methyl, applied to inshell almonds, ‘Nonpareil’ variety, at rates which resulted in deposits of 1.6, 3.6, 6.8, and 16.1 ppm, protected the nuts for yr from insect damage. Test insects were the Indian meal moth, Plodia interpunctella (Hubner), red flour beetle, Tribolium castaneum (Herbst), confused flour beetle, T. confusum Jacquelin duVal, sawtoothed grain beetle, Oryzaephilus surinamensis (L.), and merchant grain beetle, O. mercator (Fauvel). After 12 mo storage, residues on whole nuts were 0.43, 1.3, 2.0, and 3.6 ppm, respectively. The 3 highest dosages gave excellent protection (less than 2% damage) throughout the 12 mo. The lowest dosage gave good protection (less than 10% damage) for 10 mo, but thereafter, test samples contained increasing numbers of live insects although damage increase was hardly detectable. Residues on the nutmeats of the pirimiphos-methyl after 30 days in storage and 1 yr later were, respectively, 0.25–0.16, 0.42–0.47, 0.75–1.00, and 1.40–1.80 ppm. In 3 of the insecticide treatments, a slight increase in residues attests to the pirimiphos-methyl ability to translocate or migrate from the shells to the nutmeats.
Is research using the narcissistic personality inventory relevant for understanding narcissistic personality disorder

Abstract Most research on narcissism has been conducted using the narcissistic personality inventory (NPI). However, the generalizability of findings from the NPI to narcissistic personality disorder (NPD) is unknown. The current study uses two samples (48 clinical outpatients; 49 undergraduates) to address this question by examining the correlations between the NPI and interview ratings of NPD. The profiles generated by both assessments in relation to measures of general personality traits are compared to expert and meta-analytically derived profiles of NPD. The NPI and NPD assess overlapping constructs as they are significantly correlated and generate similar personality profiles. The measures diverge primarily in that NPI narcissism includes traits related to certain facets of Extraversion, which is consistent with expert conceptualizations of NPD.
Isoimmunization after Massive Transfusion for Open Heart Surgery

One hundred consecutive patients subjected to open heart surgery received an average massive transfusion of 17 units. The group consisted of 43 males and 57 females; 75 were below 40 years of age. Routine testing for blood factors in the ABO, Rh and Kell systems were performed on all donors and recipients. The sera of all donors and recipients were screened for atypical antibodies. The number of recipients and their “average antigenic dose,” as well as the number of negative antibody screenings at postoperative visits, are tabulated. Nineteen rh‘ (C)-negative patients received an average of 11.4 units of rh’ (C)-positive blood. Thirty-three rh“(E)-negative patients, two hr’ (c)-negative patients, three hr” (e)-negative patients and 37 Kell-negative patients received an average antigenic dose of 4.2, 8.5, 12.7 and 1.8 units, respectively. Two antibodies, anti-rh'(E) and anti-H, were attributed to isoimmunization. The authors conclude that the risk of detectable red cell isoimmunization by massive transfusion is probably no greater than that incurred by transfusion of a single unit.
Workplace Identities of Women in the US Labor Market

In this paper, I examine the effects of gender and race/ethnicity on American workers’ workplace identities. Literature on gender, work, and occupation suggests that gender and race are significant predictors of workers’ workplace identities. Literature also posits that self-perceived competency and reflected appraisals from others in workplaces also contribute considerably to workers’ workplace identities. However, there exists hardly any empirical study that explores the impacts of gender, race, workers’ self-perceived competency, and their reflected appraisals altogether on their workplace identities. That is what I accomplished in this study. Deriving the data from the National Study of Changing Workforce (NSCW: 2008) I ask: 1) Do women and men workers in America differ in their perceptions of workplace identities; 2) Do non-white and white workers in America differ in their perceptions of workplace identities; and 3) Do gender and race of the workers impact their workplace identities when self-perceived competency and reflected appraisals enter the equation? Analyses are based on quantitative methods. Results show that workers’ self-perceived competency and their reflected appraisals are more significant predictors of their workplace identities than gender or race.
Gprk2 controls cAMP levels in Drosophila development.

Abstract G protein-coupled receptors mediate their biological responses through the generation of second messengers, such as cAMP. The down-regulation of their activity (desensitization) is carried out, in part, by the family of G protein-coupled receptor kinases, which phosphorylate activated receptors. The Gprk2 gene in Drosophila melanogaster is a putative member of this family. The GPRK2 protein is expressed most abundantly in the ovaries and in the mushroom bodies, the brain region that is implicated in learning and memory in insects. Many of the genes that are involved in learning in Drosophila are members of a cAMP-signaling pathway and are also expressed in the mushroom bodies. These observations suggest that the Gprk2 gene may be involved in a cAMP-mediated pathway. To investigate this possibility, we tested for a genetic interaction between Gprk2 and dunce (which encodes cAMP-specific phosphodiesterase). A mutant allele of Gprk2, called gprk2 6936 , has decreased fertility as a result of reduced levels of egg laying and hatching, and developing egg chambers display defects in the formation of anterior structures. Similarly, many alleles of dunce are sterile, with an ovary phenotype that resembles gprk2 6936 . Introduction of a single copy of a hypomorphic or null allele of dunce into the gprk2 6936 background suppressed all of these defects to a significant degree. Suppression was also observed when a single copy of gprk2 6936 was introduced into a dunce background. Like mutants of rutabaga (which encodes a calcium/calmodulin-dependent adenylate cyclase), gprk2 6936 has reduced levels of cAMP. Ovaries from gprk2 6936 females contain about one third of the normal amount of cAMP. In addition, in every mutant combination where fertility is increased, cAMP levels are closer to wild type levels. These results suggest that Gprk2 is functioning in a cAMP-signaling pathway and that the underlying basis of the interaction between Gprk2 and dunce is a normalization of cAMP levels.
Monotone and probabilistic wavelet approximation

Continuous functions are approximated by wavelet operators. These preserve mone tonicity and transform continuous probability distribution functions into probability distribution functions. The degree of this approximation is estimated by establishing some Jackson type inequalities
Period of maximal susceptibility to behavioral modification by testosterone in the golden hamster

Abstract Male hamsters castrated on the day of birth (Day 1) and female hamsters were treated with the free form of testosterone (100 μg/day) on Days 1 and 2, 3 and 4, 5 and 6, 7 and 8, or 9 and 10 postnatally. Following androgen treatment in adulthood, animals treated on Days 1 and 2 or 3 and 4 showed significantly higher mounting and intromission frequencies than animals treated later in life. Sexual receptivity measures following ovarian hormone treatment showed no differences among the male groups, whereas females treated on Days 1 and 2 or 3 and 4 were significantly lower in sexual receptivity measures than females in other treatment groups. Histology of the adult ovaries indicated no modification of normal function in any treatment group. In a subsequent experiment, Day 1 castrated male and intact female hamsters were treated with the free form of testosterone on Days 1–5 (40 or 100 μg/day), 6–10 (40 or 100 μg/day), or Days 1–10 (50 μg/day). Masculine behavior measures were significantly higher in males treated Days 1–10 than in other groups. Among the females, masculine behavior was highest in those treated Days 1–5 postnatally. Sexual receptivity in both males and females was significantly depressed by testosterone treatment Days 1–10 postnatally. Ovarian histology also revealed alterations in gonadal function in females treated Days 1–5 and 1–10 postnatally. Compared with previously published findings, these data suggest that testosterone can be as effective in inducing behavioral masculinization and defeminization as testosterone propionate, provided that treatment extends over a prolonged period during early postnatal development.
Identification Effects on Advertising Response: The Moderating Role of Involvement

This study examines two important variables for advertisers, ethnicity and product involvement. We investigate the effectiveness of Hispanic-targeted advertising by exploring the impact of ad model's ethnicity on attitudes toward high- and low-involvement products. The results of our quasi-experiment suggest that appealing to strong Hispanic identifiers may be highly desirable in terms of creating favorable attitudes when advertising low-involvement products. For high-involvement products, Hispanic-targeted advertising may not be as effective since ethnicity may not be an important cue. Theoretical implications regarding the impact of distinctiveness theory and practical implications for practitioners trying to spend advertising dollars more efficiently are discussed.
Variation in nutrient content of samples of dried bakery product

Abstract Samples of dried bakery product (DBP) were obtained from a blending facility. Sixty-six samples taken over a 198-day period were assayed for moisture, protein, ether extract, and salt. The samples averaged 6.05% moisture and 9.78% ether extract, 11.94% protein and 2.52% salt (dry matter basis). The results of the study indicate that DBP samples should be constantly monitored by the feed industry to determine nutrient values to be used in feed formulation.
The association of conjunctival inflammatory cells with the results of combined cataract extraction and filtration surgery

We studied conjunctival biopsy specimens from 30 consecutive patients undergoing combined cataract extraction with posterior chamber lens implantation and trabeculectomy to determine if inflammatory cell counts and tissue structure are predictive for postoperative intraocular pressure control. We classified intraocular pressure control postoperatively by grouping patients in three ways: first, by ease of intraocular pressure control (patients with /= 16 mm Hg or receiving three glaucoma medicines); second, by those who had improved versus worsened intraocular pressure control postoperatively compared to before surgery; and third, by those who had bleb elevation versus no bleb formation. With all three classifications no statistical difference existed between groups of patients in the number of goblet cells, mast cells, neutrophils, eosinophils, macrophages, plasma cells, lymphocytes, or fibroblasts, as well as in epithelium thickness or vascular density (p > 0.05, Student's t test). Also, no statistical difference existed in mucopolysaccharide or collagen staining between groups of patients (p > 0.05, Mann-Whitney U test). This study suggests that conjunctival inflammatory cell counts or tissue structure, which can be evaluated histologically, are not associated with postoperative intraocular pressure control following combined cataract extraction and trabeculectomy.
An economic analysis of the demand for residential space heating fuel in Canada

Abstract The objectives of this study were the development and application of a model of residential space-heating demand, which incorporates economic, family-composition and structural housing factors as explanatory variables. We assess the impact of home retrofitting and other conservation actions on residential energy demand by analyzing data collected as part of a national sample of Canadian households, which are supplemented with rate-structure and energy-price data. Models of demand for space-heating fuels are estimated for residential users of electricity, natural gas and oil. Parameter estimates are corrected for sample-selection bias. The results indicate that residential consumers of space-heating fuels in Canada exhibit a price response that is significantly different from zero. Further, households facing higher than average utility prices before experiencing a fuel-price increase will, in the long run, exhibit a unitary price response.