cssi/SciSciGPT-SciSciNet huggingface dataset:
Attributing activity space as risky and safe: The social dimension to the meaning of place for urban adolescents.

The social dimension of urban adolescents’ interpretation of their activity space was investigated by examining reasons for attributing place as risky and safe, and analyzing these reasons by social network quality. Activity space and social network data were collected on 301 teens presenting for routine medical check-ups. SPSS Text Analysis for Surveys performed linguistic analyses on open-ended survey responses, applying concept derivation, concept inclusion, semantic networks, and co-occurrence rules. Results produced 13 categories of reasons for locations attributed as risky and safe. Categories were then transformed into dichotomous variables and analyzed with chi-square tests by social network quality. Results indicated two categories of reasons for locations attributed as risky: alcohol and drugs and Illegal activity, which were dependent upon social network quality. Two categories of reasons for locations attributed as safe, namely protective place and Neighborhood, were also dependent upon social network quality. These findings assert that adolescents’ social networks influence their interpretations of risk and safety, highlighting a social dimension to the meaning of place.
A 1-to-8 GHz miniaturized dielectric spectroscopy system for chemical sensing

This paper presents a miniaturized broadband dielectric spectroscopy system for dielectric characterization and chemical sensing for 1-to-8 GHz frequency range. Sensor operation is based on detecting the phase shift of a signal passing through a true-time-delay (TTD) cell at the presence of an organic chemical. Cascaded TTD cells are used to improve the detection accuracy and the sensing bandwidth. Measurements with calibration show accurate detection of frequency-dependent permittivity for organic chemicals with permittivities up to 20.
A Java API for global querying and updates for a system of databases

In this paper, we present the design of system of databases (SyDb). We also give the design and implementation of a Java API for global querying and updates on the SyDb. The databases may be heterogeneous. The API allows for queries and updates that have global references to schema elements of multiple databases to be executed in a seamless manner. The API can be used to develop collaborative applications that need access to several independent databases on the network. One such collaborative application, called the Calendar application, is illustrated in the paper. In this application each individual keeps their schedule information in their personal database. The users can schedule meetings with others, view others schedules, cancel meetings, etc. We implement the API using direct JDBC connections to databases.
Leucine-rich glioma-inactivated protein 1 antibody encephalitis A case report

Objective: To describe a case of leucine-rich glioma-inactivated protein 1 (LGI1) antibody–associated encephalitis. Methods: The clinical and ancillary data and brain MRIs were gathered retrospectively by chart review. Relevant literature on similar cases was also reviewed. Results: The diagnosis of LGI1 antibody–associated autoimmune encephalitis was based on the typical clinical presentation of seizures, psychiatric symptoms, and memory loss as well as negative diagnostic testing for cancer; the diagnosis was confirmed by positive LGI1 antibody. The patient responded favorably to treatment with IV immunoglobulin and continues to do well. Conclusion: LGI1 antibody–associated encephalitis has increasingly been recognized as a primary autoimmune disorder with good prognosis and response to treatment. Neurol Neuroimmunol
Electron-transfer polymers. XXXIX. Redox polymers based on duroquinonyl glycol

Redox polyurethanes, polyesters, and alternate copolyurethanes and copolycarbonates from two kinds of benzoquinonyl glycol were prepared based on 2-(duroquinonyl)-propan-1,3-diol. The oxidized polymer is stable. When the fully reduced polymer in solution is exposed to air the durohydroquinonyl residues are oxidized to the quinone form while the less substituted hydroquinonyl glycol residues remain stable in the reduced form. There is thus prepared polymer with oxidized and reduced groups alternating along the chain.
Climate change scenarios: risk and impact analysis for Alaska coastal infrastructure

Climate change has the potential to impose severe stress on coastal environments. Alaskan coastlines are especially vulnerable to erosion and other changes that have led to significant damage and threats to infrastructure, human health and safety, and economic prosperity. This paper describes an integration of scenario analysis with multi-criteria decision analysis to prioritise the vulnerability of communities for the development of infrastructure protection and other actions. The approach allows stakeholders to account for uncertainty in the prioritisation and also includes value judgements of the multiple relevant stakeholders. We present a case study that evaluates several climate change scenarios and formulates metrics for finding scenarios that most impact priorities. Scenarios including sea-level rise, increased frequency of forest fires, permafrost melting, and others are used. We find the increased frequency of forest fires to be the most upsetting scenario along with four communities that are identified as highly vulnerable and not sensitive to the scenarios.
Synonymies and Transfers in Elaphidiini Mostly Relating to the Genus Elaphidion Audinet-Serville (Coleoptera: Cerambycidae)

Abstract Five new synonyms and ten new combinations are proposed for taxa in Elaphidiini. Brief characterizations of the genera involved (Anelaphus Linsley, Anopliomorpha Linsley, Elaphidion Audinet-Serville, Parelaphidion Skiles, Stizocera Audinet-Serville, Trichophoroides Linsley, Xeranoplium Linsley) are included to provide bases for these taxonomic decisions. The following new combinations are proposed, all transferred from Elaphidion: Anelaphus cinnabarinum (Fisher); Anelaphus crispulum (Fisher); Anelaphus mutatum (Gahan); Anelaphus fasciatum (Fisher); Anelaphus hispaniolae (Fisher); Anopliomorpha antillarum (Fisher); Trichophoroides dozieri (Fisher); Trichophoroides signaticolle (Chevrolat); Trichophoroides variolosum (Fisher); Xeranoplium gracilis (Fisher). The following new synonymies are proposed: Elaphidion truncatipenne Fisher with Anelaphus fasciatum (Fisher); Elaphidion monticola Fisher and Anopliomorpha xylebora Cazier & Lacey with Anopliomorpha antillarum (Fisher); Elaphidion jamaicensis Fi...
An examination of potential seasonal predictability in recent reanalyses

This study examined potential seasonal predictability of precipitation and 2-m temperature in the recent global reanalyses from 1979 to 2012. The reanalyses being investigated are R1, R2, ERA-40, JRA25, ERA-I, MERRA, CFSR and 20CR. When compared against Global Precipitation Climatology Project (GPCP) precipitation, ERA-I and CFSR provide the best estimates of potential predictability, MERRA, R1 and R2 overestimate predictability and ERA-40 and JRA25 are unrealistic in the tropics. Predictability estimates of 2-m temperature from 20CR, JRA25, R1, MERRA, CFSR and R2 exhibit better agreement with the reanalysis ensemble mean than ERA-40 and ERA-I, which identify less predictability.
Mountain Yellow-legged Frogs (Rana muscosa) did not Produce Detectable Antibodies in Immunization Experiments with Batrachochytrium dendrobatidis

Chytridiomycosis is a devastating infectious disease of amphibians caused by the fungal pathogen Batrachochytrium dendrobatidis (Bd). A growing number of studies have examined the role of amphibian adaptive immunity in response to this pathogen, with varying degrees of immune activation reported. Here we present immunologic data for the mountain yellow-legged frog, Rana muscosa, and the Sierra Nevada yellow-legged frog, Rana sierrae, which are two endangered and ecologically important species experiencing Bd-inflicted declines. Previous studies on these species that examined transcriptional response during Bd infection, and the effective of immunization, provided little evidence of immune activation to Bd. However, the studies did not directly assay immune effectors in the frog hosts. We performed experiments to examine antibody production, which is a hallmark of systemic adaptive immune activation. We used controlled laboratory experiments and enzyme-linked immunosorbent assays to examine the antibody response to Bd immunization and live Bd exposure. Rana muscosa and R. sierrae individuals did not produce detectable antibodies with the capacity to bind to denatured Bd antigens under our experimental conditions. While we cannot rule out antibody response to Bd in these species, our results suggest weak, poor, or inefficient production of antibodies to denatured Bd antigens. Our findings are consistent with susceptibility to chytridiomycosis in these species and suggest additional work is needed to characterize the potential for adaptive immunity.
Vitamin D-induced calcium binding factor in rat intestinal mucosa.

SummaryOral administration of 500 IU of vitamin D2 or vitamin D3 to rachitic rats resulted in the elaboration of a Ca-binding factor which could be detected in the supernatant fraction of duodenal mucosal homogenates at 72 hours after administration of the vitamin. This factor was found to be associated with the initial or protein containing portion of the supernatants after percolation through Sephadex G-25; this indicates that the factor is a macromolecule, presumably a protein. Further separation of the supernatants by Sephadex G-100 gel filtration showed that the increased binding activity seen after vitamin D administration was mainly associated with only one of the protein peaks present in the Sephadex G-100 fractions. This particular peak was much less prominent in the fractionated supernatant of the mucosal homogenates from rachitic rats. The results suggest that the vitamin D-dependent binding activity is due to the presence of a specific calcium binding protein in the supernatant fraction of duo...
Smoking Status as the New Vital Sign: Effect on Assessment and Intervention in Patients Who Smoke

Objective To assess the effect of expanding the vital signs to include smoking status. Design We prospectively conducted, exit interviews with patients at a general internal medicine clinic in Madison, Wisconsin, during a 16-month period from 1991 to 1993. Methods Patients were surveyed briefly before (N = 870) and after (N = 994) the implementation of a simple institutional change in clinical practice. This change involved training the staff in how to use progress notepaper with a vital sign stamp that included smoking status (current, former, or never) along with the traditional vital signs. Included in the survey were questions about whether the patient smoked, whether the patient was asked that day about smoking status (by a clinician or other staff), and, for smokers, whether they were urged to quit smoking and given specific advice on how to do so. Results After expansion of the vital signs, patients were much more likely to report inquiries about their smoking status on the day of a clinic visit (an increase from approximately 58% at baseline to 81 % at intervention; P P P Conclusion Expanding the vital signs to include smoking status was associated with a dramatic increase in the rate of identifying patients who smoke and of intervening to encourage and assist with smoking cessation. This simple, low-cost intervention may effectively prompt clinicians to inquire about use of tobacco and offer recommendations to smokers.
Calcium Hydroxide Crystal Evolution upon Aging of Lime Putty

Aging of lime putty, by storing slaked lime under excess water for extended periods of time, has been recognized for centuries as a means to improve the quality of hydrated lime as a binder in lime-based mortar and plasters. However, there is limited, and at times contradictory, evidence about the effect of the extended exposure of portlandite (Ca(OH)2) to water. Our data from X-ray diffraction, nitrogen adsorption, and scanning electron microscopy studies indicate that portlandite crystals undergo both an important size reduction and a significant morphological change, developing submicrometer, platelike crystals upon aging. A model for portlandite evolution is proposed and discussed, based upon (a) differences in solubility between {0001} basal pinacoid faces, and {1010} prism faces, and (b) heterogeneous secondary nucleation of nanometer-scale platelike portlandite crystals.
OFDMA Based Multiparty Medium Access Control in Wireless Ad Hoc Networks

We present the Concurrent Transmission or Reception Multiple Access (CTRMA) protocol as an example of embracing interference in wireless ad hoc networks, even when each node is endowed with a single half-duplex radio and a single antenna. CTRMA uses OFDMA to enable each node to either send or receive multiple concurrent transmissions over orthogonal subchannels (groupings of subcarriers). With CTRMA, a node transmits multiple transmissions at the same time by negotiating the subchannels over which transmissions take place by using information attained with a channel priority assignment algorithm. CTRMA supports dynamic bandwidth selection and enhances channel reuse. We prove the correctness of CTRMA and use simulation experiments to illustrate the major performance advantages of CTRMA over prior channel access protocols proposed for single-radio single-channel, single-radio multi-channel and multi-radio multi-channel wireless ad hoc networks.
Theiler's virus infection induces a predominant pathogenic CD4+ T cell response to RNA polymerase in susceptible SJL/J mice.

Theiler's murine encephalomyelitis virus (TMEV)-induced immune-mediated demyelinating disease in susceptible mouse strains has been extensively investigated as a relevant model for human multiple sclerosis. Previous investigations of antiviral T-cell responses focus on immune responses to viral capsid proteins, while virtually nothing is reported on immune responses to nonstructural proteins. In this study, we have identified noncapsid regions recognized by CD4+ T cells from TMEV-infected mice using an overlapping peptide library. Interestingly, a greater number of CD4+ T cells recognizing an epitope (3D21-36) of the 3D viral RNA polymerase, in contrast to capsid epitopes, were detected in the CNS of TMEV-infected SJL mice, whereas only a minor population of CD4+ T cells from infected C57BL/6 mice recognized this region. The effects of preimmunization and tolerization with these epitopes on the development of demyelinating disease indicated that capsid-specific CD4+ T cells are protective during the early stages of viral infection, whereas 3D21-36-specific CD4+ T cells exacerbate disease development. Therefore, protective versus pathogenic CD4+ T-cell responses directed to TMEV appear to be epitope dependent, and the differences in CD4+ T-cell responses to these epitopes between susceptible and resistant mice may play an important role in the resistance or susceptibility to virally induced demyelinating disease.
Spectroscopy of photoexcitations in polyacetylene: the first decade

I review the saga of photoexcitations in trans-(CH)x as of 1992. I show that both neutral and charged solitons are photogenerated with high quantum efficiency. We followed their dynamics from subpicosecond to tens of milliseconds and show that interesting physics can be extracted from the transient response in each time domain. § 1.· Introduction
Attitudes of Missouri Small Game Hunters Toward Nontoxic-Shot Regulations

Wildlife managers are becoming more concerned about the exposure of birds, in addition to waterfowl, to spent lead shot. Knowledge of hunter attitudes and their acceptance of nontoxic-shot regulations will be important in establishing new regulations. Our objective was to assess the attitudes of small game hunters in Missouri, USA, toward a nontoxic-shot regulation for small game hunting, specifically for mourning doves (Zenaida macroura). Most hunters (71.7–84.8%) opposed additional nontoxic-shot regulations. Hunters from rural areas, hunters with a rural background, hunters who hunt doves, hunters who currently hunt waterfowl, hunters who primarily use private lands, and current upland game hunters were more likely to oppose new regulations. For mourning dove hunting, most small game hunters (81.1%) opposed further restrictions; however, many non-dove hunters (57.1%) expressed no opinion. Because our results demonstrate that most small game hunters and dove hunters in Missouri are decidedly against further nontoxic-shot regulations, any informational and educational programs developed to accompany future policy changes must address their concerns.
Use of Nape and Peri-Auricular Hair by Follicular Unit Extraction to Create Soft Hairlines and Temples: My Experience With 128 Patients

Background Hairlines and temples can look unnatural due to coarseness of the safe donor area of transplanted scalp hair. Although the thinner caliber of nape and peri-auricular (NPA) hair would be ideal to create softer hairlines, they have not been used mainly because of concerns that they are nonpermanent. Objective We assessed the outcome of NPA hair transplanted to hairlines and temples in selected patients. Methods During November 2006 to November 2011, follicular unit extraction (FUE) transplantation using NPA hair was conducted in 128 patients following a shave test involving the visual evaluation of hair density and caliber of shaved head donor areas. The test was used to determine permanent versus nonpermanent donor areas. A questionnaire was sent to patients to assess satisfaction with their restored hairlines, with a follow-up questionnaire sent to those who initially responded. Results Three-quarters of patients are good candidates for use of NPA hair to the hairlines and temples based on the shave test. Of 128 patients transplanted, 71% responded and reported a mean overall satisfaction of 8.3 (scale, 1-10). Patients saw full hair coverage at the recipient area at a mean of 9.6 months after surgery. Nineteen patients reported lost grafts. Thirty-three patients responded to a second survey and reported a mean overall satisfaction of 8.5 at an average of 4.6 years after surgery; only 5 (15%) new instances of graft loss were reported. Conclusions Soft, natural-looking hairlines can be created in select patients using NPA hair as a donor source by FUE hair transplantation. Level of Evidence 4![Graphic][1] Therapeutic [10.1093/asj/sjv145][2] [1]: /embed/inline-graphic-1.gif [2]: /lookup/doi/10.1093/asj/sjv145
The phenotype of the neoplastic cells of hairy cell leukemia studied with monoclonal antibodies

Eighteen cases of hairy cell leukemia were studied with a battery of polyclonal anti-Ig and nine monoclonal antibodies to determine the lineage of the hairy cells (HC) and the stage of their maturation arrest. Hairy cells tend to nonspecifically bind many antisera and precautions had to be taken to avoid nonspecific fluorescence of the cells. All but one case was reactive with one light chain type and one or more heavy chain isotype antisera as reported before. All cases studied were positive for monomorphic HLA-DR determinants, using monoclonal antibody 7.2. Most cases tested (6/7) were positive with the B-lineage related antibody PI 153/3. While most cases (15/18) were nonreactive with the B-lineage related antibody BA-1, they became positive (5/5) following in vitro culture. Seven out of nine cases were reactive with OKM1. Common acute lymphoblastic leukemia antigen (CALLA) was absent in all (15) cases tested and the ALL associated structure p24/BA-2 was absent from 16 of 18 cases. HC from none of the cases were clearly positive with the T-cell antibodies 9.6., or TA-1, whereas in only 1/18 the cells reacted with T101. The results of this study support the B cell lineage of most HC, and show the presence of multiple phenotypes. In combination with the surface Ib present on the cells, a hierarchy of phenotypes is postulated, with SIg-ormu delta, BA-1+, PI 153/3+, HLA-DR+ being the most immature, and SIg(alpha) gamma, BA-1-, PI 153/3-, HLA-DR+ the most mature.
Bis[tris­(3,5-dimethyl-1H-pyrazol-1-yl-κN2)meth­yl]sodium trifluoro­methane­sulfonate

In the title salt, [Na(C16H22N6)2]CF3SO3, the Na+ cation is coordinated by six N atoms from two tridentate tris­(3,5-dimethyl­pyrazol-1-yl)methane ligands in a distorted octa­hedral geometry. The Na—N distances range from 2.427 (3) to 2.507 (3) A, intra-ligand N—Na—N angles range from 74.71 (8) to 79.31 (9)°, and adjacent inter-ligand N—Na—N angles range between 100.42 (9) and 104.97 (9)°. The structure is twinned by inversion [occupancy factors = 0.50 (9)] and the trifluoro­methane­sulfonate anion is disordered, with two end-over-end orientations of unequal occupancy [0.781 (3) and 0.219 (3)].
Nicotine administration attenuates methamphetamine-induced novel object recognition deficits

Background: Previous studies have demonstrated that methamphetamine abuse leads to memory deficits and these are associated with relapse. Furthermore, extensive evidence indicates that nicotine prevents and/or improves memory deficits in different models of cognitive dysfunction and these nicotinic effects might be mediated by hippocampal or cortical nicotinic acetylcholine receptors. The present study investigated whether nicotine attenuates methamphetamine-induced novel object recognition deficits in rats and explored potential underlying mechanisms. Methods: Adolescent or adult male Sprague-Dawley rats received either nicotine water (10–75 μg/mL) or tap water for several weeks. Methamphetamine (4×7.5mg/kg/injection) or saline was administered either before or after chronic nicotine exposure. Novel object recognition was evaluated 6 days after methamphetamine or saline. Serotonin transporter function and density and α4β2 nicotinic acetylcholine receptor density were assessed on the following day. Results: Chronic nicotine intake via drinking water beginning during either adolescence or adulthood attenuated the novel object recognition deficits caused by a high-dose methamphetamine administration. Similarly, nicotine attenuated methamphetamine-induced deficits in novel object recognition when administered after methamphetamine treatment. However, nicotine did not attenuate the serotonergic deficits caused by methamphetamine in adults. Conversely, nicotine attenuated methamphetamine-induced deficits in α4β2 nicotinic acetylcholine receptor density in the hippocampal CA1 region. Furthermore, nicotine increased α4β2 nicotinic acetylcholine receptor density in the hippocampal CA3, dentate gyrus and perirhinal cortex in both saline- and methamphetamine-treated rats. Conclusions: Overall, these findings suggest that nicotine-induced increases in α4β2 nicotinic acetylcholine receptors in the hippocampus and perirhinal cortex might be one mechanism by which novel object recognition deficits are attenuated by nicotine in methamphetamine-treated rats.
Application of the model of allostasis to older women's relocation to senior housing.

Objectives: Adjustment to senior housing entails significant lifestyle changes and is a stressful process. The adaptation process is dynamic and has yet to be studied using the conceptual model of ...
Prevalence and Clinical Correlates of Coronary Artery Disease among New Dialysis Patients in the United States: A Cross-Sectional Study

Despite the high prevalence of coronary artery disease (CAD) among patients with end-stage renal disease (ESRD), few studies have identified clinical correlates using national data. The purpose of this study was to determine the prevalence and clinical associations of CAD in a national random sample of new ESRD in the United States in 1996/1997 (n = 4025). Data on demographic characteristics and comorbidities were obtained from the Dialysis Morbidity and Mortality Study, Wave 2. The principal outcome was CAD, defined as the presence of a previous history of CAD, myocardial infarction, or angina, coronary artery bypass surgery, coronary angioplasty, or abnormal coronary angiographic findings. Multivariate logistic regression analysis was used to assess the relationship of conventional factors and proposed uremic factors to the presence of CAD. CAD was present in 38% of patients. Of the total cohort, 17% had a history of myocardial infarction and 23% had angina. Several conventional risk factors, including advancing age, male gender, diabetes mellitus, and smoking, were significantly associated with CAD. Of the proposed uremic factors, lower serum albumin levels but higher residual renal function and higher hematocrit values were significantly associated with the presence of CAD. Vascular comorbid conditions, structural cardiac abnormalities, white race, and geographic location were also strongly correlated with the presence of CAD. This national study suggests that several conventional CAD risk factors may also be risk factors for CAD among the ESRD population. This study identifies nonconventional factors such as serum albumin levels, vascular comorbid conditions, and structural cardiac abnormalities as important disease correlates. Future logitudinal studies are required to explore the relative importance of the relationships observed here.
The Use of Atomic Absorption Spectroscopy in Hemoglobinometry: I. The Determination of Iron in Hemoglobin

Atomic absorption is finding wide acceptance as a convenient method of metal analysis in biologic materials. The specificity and accuracy of the method, and the convenience of direct analysis of samples, requiring no preparation other than simple dilution, make the use of this technic highly desirable for iron analysis of hemoglobin. In order to take full advantage of the potentials of the technic, we were interested in investigating whether the analysis of aqueous hemoglobin solutions by direct aspiration into the flame gave accurate values for iron. Interfering effects might be observed from the incorporation of the iron in the hemoglobin molecule itself, or from the presence of other components of the sample matrixderiving from whole blood constituents. We were able to show that very accurate quantitative iron determinations can be obtained when simple aqueous dilutions of toluene hemolysates of hemolyzed washed cells or of hemolyzed whole blood were analyzed. No effect on the iron values was seen from the concomitant constituents of hemolysates or of whole blood when dilutions of 100-fold or greater were used. Instrumentation and technics. A PerkinElmer atomic absorption spectrophotometer model 303 (Perkin-EImer Corporation, Norwalk, Connecticut) was used. The standard instrument settings were: neon-filled iron hollow cathode tube, operating current, 30 ma.; analytical resonance line, 24S3 A; monochromator slit, 3; flame, acetylene-air, stoichiometric. The baffle system of the burner was modified as described previously. The aspirator capillary was replaced by a 10-in. length of polyethylene tubing of 0.030 in. i.d. (Clay-Adams Intramedic Pol}'ethylene tubing, PE 60). A wide-slot
Geographic Variation of Germination, Growth, and Mortality in Sugar Maple (Acer saccharum): Common Garden and Reciprocal Dispersal Experiments

If current temperature trends continue and increase as predicted by general circulation models, the persistence and migration of sugar maple (Acer saccharum) at its northern limit will become cruci...
Fluid control devices, "rheostasis", and the human circulation.

Summary The development of fluid control devices has contributed greatly to the understanding of the behavior of moving fluids. Innate examples of these devices may exist in the human circulation at sites of normal arterial branching or at points where pathologic changes have appeared. Hydraulic mechanisms can reduce flow to near standstill in normally patent channels, an effect termed “rheostasis.” Should the phenomena observed in fluid control devices operate in the circulation of man, then rheostasis could appear in normal vessels of suitable configuration, could arise in atheromatous vessels, or could occur as an unexpected consequence of the appearance of collateral circulation. Rheostasis may thus explain the high incidence of myocardial infarction with but partially occluded coronary arteries. Fluid jet control could divert blood flow from the internal carotid to the external carotid artery, from the vertebral to the subclavian artery, or from one renal artery branch to another, producing rheostasis and ischemia in the affected organs. Further examples may exist at the celiac artery, in the circle of Willis, and, when air is the moving fluid, at the bifurcations of the tracheobronchial tree. The human circulation may be examined profitably by knowledge obtained from the study of Coanda or boundary wall effects, proportional flow elements, fluid-switching devices, and fluid amplifiers. Concepts derived from the new field of fluidics may supply a common denominator to clinical syndromes as seemingly disparate as angina pectoris, intermittent cerebral artery insufficiency, renal hypertension, and pulmonary ventilation disorders.
Structural and magnetic characterization of the one-dimensional S = 5 /2 antiferromagnetic chain system SrMn (V O 4 ) (OH )

The descloizite-type compound, SrMn(VO4)(OH), was synthesized as large single crystals (1-2mm) using a high-temperature high-pressure hydrothermal technique. X-ray single crystal structure analysis reveals that the material crystallizes in the acentric orthorhombic space group of P212121 (no. 19), Z = 4. The structure exhibits a one-dimensional feature, with [MnO4] chains propagating along the a-axis which are interconnected by VO4 tetrahedra. Raman and infrared spectra were obtained to identify the fundamental vanadate and hydroxide vibrational modes. Magnetization data reveal a broad maximum at approximately 80 K, arising from one-dimensional magnetic correlations with intrachain exchange constant of J/kB = 9.97(3) K between nearest Mn neighbors and a canted antiferromagnetic behavior below TN = 30 K. Single crystal neutron diffraction at 4 K yielded a magnetic structure solution in the lower symmetry of the magnetic space group P21 with two unique chains displaying antiferromagnetically ordered Mn moments oriented nearly perpendicular to the chain axis. Lastly, the presence of the Dzyaloshinskii Moriya antisymmetric exchange interaction leads to a slight canting of the spins and gives rise to a weak ferromagnetic component along the chain direction.
Status report. Characterization of Weld Residual Stresses on a Full-Diameter SNF Interim Storage Canister Mockup.

This report documents the mockup specifications and manufacturing processes; the initial cutting of the mockup into three cylindrical pieces for testing and the measured strain changes that occurred during the cutting process; and the planned weld residual stress characterization activities and the status of those activities.
Accreditation under Fire

The system of educational accreditation has been publicly critiqued by those in higher education within accredited institutions and individuals and organizations in the educational community, as well as by a variety of people and organizations outside academe who disparage the usefulness and efficacy of the current structure. Being that the nature of public discourse usually involves complexities and speculation, the truth is that several of these alarms are probably warranted while some are not. Even as early as 1939, Samuel P. Capen, the chancellor of the University of Buffalo, stated that educational leaders around America were tired and distressed at having the educational and financial procedures of their organizations commandeered by careless strangers who had selfish or unclear reasons as their true goals (Capen 1939; Young et al. 1983). Within the accreditation community, some people have described the procedure as intangible, imprecise, shallow, and full of vague meanings that vary among organizations and stakeholders. This is due, in part, to the lack of understanding about the true nature and role of accreditation among the general public or even among the educational organizations that this oversight system serves (Young et al. 1983). While some of the critiques have come from ignorance or misunderstandings about the proper role and power of accreditation, other pessimistic observations are founded on the conviction that the procedure could accomplish far greater outcomes if only certain changes in the accreditation objectives and methods were implemented.
3 – SOUTHERN BLOT ANALYSIS

This chapter presents the methods for Southern blotting using a nonradioactive biotinylated nucleic acid detection system or a radioactively labeled DNA detection system. Nonradioactive labeling of nucleic acids to be used as hybridization probes has several advantages over radioactive labeling of nucleic acids. Types of nonradioactive labeling and detection systems used include the horseradish peroxidase system, the digoxigenin-anti-digoxigenin system, and the biotin-streptavidin system. With all three of these systems the hybridized probe may be detected with chromogenic (colorimetric) substrates (substrates that produce a colored product) or chemiluminogenic substrates (substrates that produce products that give off light) for the enzymes involved in each system. In the horseradish peroxidase nonradioactive system, a chemical reaction is used to label the DNA to be used as a probe. Avidin–biotin binding reactions can have high backgrounds because the basic isoelectric point of avidin favors stronger electrostatic interactions and the carbohydrate moiety of avidin has a tendency to bind to lectin like proteins. Problems with high backgrounds can be avoided by using a biotin–streptavidin system. A biotin-containing nucleotide analog is incorporated into DNA bynick translation or by random primer labeling After hybridization, the biotin-labeled DNA is detected by the tight and specific binding of streptavidin that has been conjugated to alkaline phosphatase. A chromogenic or a chemiluminogenic substrate for alkaline phosphatase is used.
A Royal Boat Burial and Watercraft Tableau of Egypt's 12th Dynasty (c.1850 BCE) at South Abydos

Excavations at Abydos, Egypt, during 2014–2016 have revealed the remains of a boat burial dating to the reign of Senwosret III (c.1850 BCE). The boat burial occurred inside a specially prepared, subterranean vaulted building. Surviving elements of planking appear to derive from a nearly 20 m-long boat that was buried intact but later dismantled for reuse of the wood. The vessel may belong to a group of royal funerary boats associated with the nearby tomb of Senwosret III. Incised on to the interior walls of the boat building is an extensive tableau including 120 surviving drawings of pharaonic watercraft. A unique deposit of pottery vessels was found associated with the ceremonial burial of this royal boat.
Molecular Methods for Evaluation of K+Channel Expression and Distribution in the Heart

One of the most significant challenges in cardiac physiology is to acquire a detailed understanding of the molecular basis of cardiac repolarization. To approach this problem, it is necessary to identify and fully characterize each of the K+ currents that are responsible for repolarization. In the last several years, there has been much progress made in phenotypic characterization of these currents (Barry and Nerbonne, 1996; Brown, 1997; Doyle and Stubbs, 1998; Jongsma, 1998;Tseng, 1999). In principle, knowledge of the detailed physiological and pharmacological properties of these currents should have led to ready identification of the corresponding channel molecules. This approach, however, has been complicated by two factors. First, there are many cardiac K+ currents whose presence, properties, and distribution throughout the heart can vary depending on the species and stage of development. Second, the molecular profile of the K+ channels responsible for these currents is extremely complex. There have been roughly 30 K+ channel α-subunit clones reported (Chandy and Gutman, 1995; Jan and Jan, 1997), and many have the ability to “mix and match” to form heteromultimers (Li et al., 1993). Furthermore, many or possibly all of these channel complexes have ancillary subunits which may contribute to their physiological properties (Brown, 1997; Robertson, 1997; Xu and Li, 1998).
Technology Dependence of the Nervous System

Multiple childhood medical conditions affect the nervous system, including intracranial hemorrhage, cerebral palsy, spina bifida, and intractable epilepsy. Implantable devices used in these patients can improve quality and duration of life. While the devices are often managed by neurosurgeons or neurologists, a basic understanding of their function allows the primary care physician to recognize and assist in early management of device complications including failure.
The Impact of Product Type and Parity on the Informational Content of Advertising

Issues regarding the factual information content of advertising messages under conditions of product parity and product type (i.e., goods vs. services) are reviewed and research propositions are offered. Data derived from content analysis of over 17,000 newspaper ads and 9800 TV ads were used to investigate the propositions’ validity. Regression analysis (p < .05) indicated that ads for intangible dominant products (i.e., services) and low parity products contain more factual information cues than their counterparts. When the two conditions are viewed together (i.e., parity and product type), analysis showed that parity influences factual informational content but not to the same degree as product tangibility. In essence, advertisers appear to be responding more to product type than to product parity prescriptions when it comes to including factual information in their ads.
Laser Measurements in Cardiovascular Flow Dynamics Research

Flow dynamic measurement in cardiovascular systems usually refers to the measurement of the time dependent pressure, blood flow velocity, and the volumetric flow rates. Generally, flow dynamic measurements in cardiovascular systems are rather difficult. This is not only because that the flow is basically unsteady, but also the physical frame of reference is always moving. During the past decades, various types of flow measurement instruments have been designed and developed. Among which, laser Doppler anemometer (LDA) has been one of the most favorite tool in laboratory studies.
The impact of cost structure on supply chain cash flow risk

Managing supply chain cash flow risk has become a crucial task for many cash-stressed businesses. Cash flows usually lag behind operating earnings and exhibit higher volatility than earnings, making them less predictable. Through the three components of the cash conversion cycle – days in inventory, receivables, and payables, this study investigates the impact of cost structure – cost ratios and cost compositions – on cash flow risk (standard deviation) and explains why and how management philosophies, such as Just-In-Time, and new production technologies, such as 3D printing, can lower cash flow risk by shortening days in inventory and shifting cost structure. An analytical model built on a simple demand process examines the basic relationship between cost structure and cash flow risk while a simulation approach studies the same relationship under a more general demand process with additional modelling considerations and a benchmark test. The simulation approach is applied on a publicly traded company’s ...
Abstract 3231: Identifying high quality, potent and selective pyrimidinylthienopyrrolone inhibitors of ERK1/2 kinase: LY3214996

The ERK/MAPK pathway plays a central role in the regulation of critical cellular processes and is activated in more than 30% of human cancers. While targeting upstream nodes with RAF and MEK inhibitors has proven effective clinically, resistance frequently develops through reactivation of the pathway. ERK inhibitors have the potential to address resistance caused by ERK reactivation. Herein, a potent, selective small molecule ERK1/2 inhibitor is described. LY3214996 possesses an optimal balance of potency (hERK1 IC50 5 nM, hERK2 IC50 5nM, pRSK IC50 0.43 µM), solubility (FaSSIF solubility at pH 6.5 0.133 µM), PK properties (dog, AUCoral 23800 nM*hr, CL 12.1 mL/min/kg, bioavailability 75.4%), IVTI (TED50 =16 mg/kg pRSK1) and demonstrated significant in vivo efficacy in several human cancer xenograft models. LY3214996 is currently undergoing early clinical evaluation. Citation Format: Gaiying Zhao, William T. McMillen, Shufen Cai, Baohui Zhao, Matthew Whitesell, Wenjuan Wu, Karen Huss, Bryan Anderson, Xiu-Juan Yuan, Susan Jaken, Lisa Kindler, Robert S. Flack, Denis McCann, Brian Mathes, Andrew J. Dropsey, Jennie Walgren, Eunice Yuen, Jason Manro, Xueqian Gong, Guillermo Cortez, Johnathan McLean, Michael J. Rodriguez, Ramon V. Tiu, Shripad V. Bhagwat, Sajan Joseph. Identifying high quality, potent and selective pyrimidinylthienopyrrolone inhibitors of ERK1/2 kinase: LY3214996 [abstract]. In: Proceedings of the American Association for Cancer Research Annual Meeting 2017; 2017 Apr 1-5; Washington, DC. Philadelphia (PA): AACR; Cancer Res 2017;77(13 Suppl):Abstract nr 3231. doi:10.1158/1538-7445.AM2017-3231
EFFECT OF HEEL LIFTS ON PATELLOFEMORAL JOINT STRESS DURING RUNNING.

Background Patellofemoral pain is a debilitating injury for many recreational runners. Excessive patellofemoral joint stress may be the underlying source of pain and interventions often focus on ways to reduce patellofemoral joint stress. Purpose Heel lifts have been used as an intervention within Achilles tendon rehabilitation programs and to address leg length discrepancies. The purpose of this study was to examine the effect of running with heel lifts on patellofemoral joint stress, patellofemoral stress impulse, quadriceps force, step length, cadence, and other related kinematic and spatiotemporal variables. Study Design A repeated-measures research design. Methods Sixteen healthy female runners completed five running trials in a controlled laboratory setting with and without 11mm heel lifts inserted in a standard running shoe. Kinetic and kinematic data were used in combination with a static optimization technique to estimate individual muscle forces. These data were inserted into a patellofemoral joint model which was used to estimate patellofemoral joint stress and other variables during running. Results When running with heel lifts, peak patellofemoral joint stress and patellofemoral stress impulse were reduced by a 4.2% (p=0.049) and 9.3% (p=0.002). Initial center of pressure was shifted anteriorly 9.1% when running with heel lifts (p 0.05) were shown between conditions. Conclusions Heel lift use resulted in decreased patellofemoral joint stress and impulse without associated changes in step length or frequency, or other variables shown to influence patellofemoral joint stress. The center of pressure at initial contact was also more anterior using heel lifts. The use of heel lifts may have therapeutic benefits for runners with patellofemoral pain if the primary goal is to reduce patellofemoral joint stress. Level of Evidence 3b.
False positive plasma genotyping due to clonal hematopoiesis

Purpose: Plasma cell-free DNA (cfDNA) genotyping is increasingly used in cancer care, but assay accuracy has been debated. Because most cfDNA is derived from peripheral blood cells (PBC), we hypothesized that nonmalignant mutations harbored by hematopoietic cells (clonal hematopoiesis, CH) could be a cause of false-positive plasma genotyping.Experimental Design: We identified patients with advanced non-small cell lung cancer (NSCLC) with KRAS, JAK2, or TP53 mutations identified in cfDNA. With consent, PBC DNA was tested using droplet digital PCR (ddPCR) or next-generation sequencing (NGS) to test for CH-derived mutations.Results: We first studied plasma ddPCR results from 58 patients with EGFR-mutant NSCLC. Two had KRAS G12X detected in cfDNA, and both were present in PBC, including one where the KRAS mutation was detected serially for 20 months. We then studied 143 plasma NGS results from 122 patients with NSCLC and identified 5 JAK2 V617F mutations derived from PBC. In addition, 108 TP53 mutations were detected in cfDNA; for 33 of the TP53 mutations, PBC and tumor NGS were available for comparison, and 5 were present in PBC but absent in tumor, consistent with CH.Conclusions: We find that most JAK2 mutations, some TP53 mutations, and rare KRAS mutations detected in cfDNA are derived from CH not tumor. Clinicians ordering plasma genotyping must be prepared for the possibility that mutations detected in plasma, particularly in genes mutated in CH, may not represent true tumor genotype. Efforts to use plasma genotyping for cancer detection may need paired PBC genotyping so that CH-derived mutations are not misdiagnosed as occult malignancy. Clin Cancer Res; 24(18); 4437-43. ©2018 AACRSee related commentary by Bauml and Levy, p. 4352.
Nationalism, personality, and decision-making: Evidence from an SJT for military multi-national teaming scenarios

Abstract The global reach of the US military requires commanders to manage multinational teams effectively but cultural factors make effective decision-making challenging. This article reports a series of three studies with a total sample of 696 participants. They examined how sociocultural factors, personality traits, and decision-making competencies correlated with performance on a Situation Judgment Test (SJT) for military multinational decision-making. Predictors of SJT performance included general decision-making competencies, low nationalism, and Big Five and Dark Triad personality traits. Higher cultural intelligence (CQ) did not predict the SJT. Nationalism was associated with poorer decision-making in general, as well as traits associated with social agency. Regression analyses suggested that multiple dimensions predicted performance independently. Several factors linked to poor performance were associated with high confidence. Lack of cognitive flexibility may also contribute to impairments. Multivariate assessments of commanders may be utilized to guide training towards the individual's specific vulnerabilities.
A communication training program for couples.

A structured educational program attempts to increase each partner's self awareness and contribution to interaction within significant relationships
The Working Alliance in Teaching and Learning: Theoretical Clarity and Research Implications

The working alliance has proven to be a valuable concept in psychotherapy research, but its utility in understanding change processes in teaching and learning has yet to be realized. Despite previous applications of the concept to educational contexts, empirical research on the working alliance in student-teacher collaborations is lacking. To address this disconnect and encourage research, I present an overview of working alliance theory, clarify the ap plication of the concept to educational contexts, and explore its relationship to the scholarship of teaching and learning. Potential applications of working alliance theory to teaching and learning research are considered as informed by developments within psychotherapy research.
Fourier transform approach for inverse dimension reduction method

Estimating an inverse regression space is especially important in sufficient dimension reduction. However, it typically requires a tuning parameter, such as the number of slices in a slicing method...
Industry Payments to Physicians and Prescriptions of Brand-Name Proton-Pump Inhibitors.

ObjectiveTo characterize the association between industry payments and prescriptions of 2 brand-name proton-pump inhibitors (PPIs).Study DesignCross-sectional retrospective.SettingPhysicians nation...