cssi/SciSciGPT-SciSciNet huggingface dataset:
Phorbol Myristate Acetate: Effect of a Tumor Promoter on Insulin Release from Isolated Rat Islets of Langerhans*

Phorbol myristate acetate (PMA), a tumor- promoter capable of influencing biologic functions of many cell systems, has been demonstrated to augment glucose-initiated insulin release from isolated rat islets of Langerhans. PMA caused a 2-fold increase in insulin release. This effect of PMA did not alter the sigmoidal relationship of insulin released to glucose concentration. The effect of PMA on insulin secretion from the islet β-cells persists and a challenge with glucose alone, subsequent to a pulse of PMA, elicits an augmented insulin release response. (Endocrinology 102: 706, 1978)
Coronary artery or myocyte: wherein lies the diagnosis?

Concision in style, precision in thought, decision in life. — —Victor Hugo, 1907* Patients who have left ventricular (LV) contractile dysfunction with dilatation of one or both ventricles receive the broad diagnosis of dilated cardiomyopathy (DCM), though further refinement is invariably required to guide appropriate therapy. Etiologic considerations span metabolic, toxic, infiltrative, structural, and congenital disorders, many of which may be apparent on initial history; hypertension and atherosclerotic coronary artery disease (CAD) are often the lead suspects (Table). Even in the absence of a defined genetic syndrome, DCM often occurs within a milieu of genetic susceptibility, underscoring the need to elicit a careful family history. Article see p 199 If bedside assessment does not point to an obvious etiology, the initial workup of newly diagnosed DCM typically includes one or more diagnostic procedures. The ECG has proven utility amidst an array of imaging options for the patient with DCM, even if the merit of Q waves in defining infarcted myocardium has waned. Recognition of epsilon waves should promote consideration of arrhythmogenic right ventricular cardiomyopathy,1 atrioventricular block with the appropriate family history should trigger suspicion of lamin A/C cardiomyopathy,2 and low QRS voltage despite thickened myocardium should raise one’s suspicion of amyloidosis.3 View this table: Table. Causes of Cardiomyopathy Accurate diagnosis in the initial workup of DCM dictates distinct treatment pathways and attendant variability in prognosis. Excluding CAD in the patient with newly diagnosed DCM holds particular import, as dysfunction caused by hibernating myocardium may improve considerably …
Stepfathers With Minor Children Living at Home: Parenting Perceptions and Relationship Quality

This study uses data from the National Survey of Families and Households to examine stepfathers' perceptions about their stepfather role and the quality of their relationship with their oldest minor stepchild living at home. The sample includes 195 stepfathers coresiding with a spouse or nonlegal partner. Results indicate that these stepfathers have diverse perceptions about seven different aspects of the stepfather role. Almost 52% of stepfathers disagree at least somewhat with the notion that it is harder to love stepchildren than your own children while 33% report that it is at least somewhat true that they are more like a friend than a parent to their stepchildren. Stepfathers who (a) live with both step- and biological children in the same household, (b) become a father figure to younger children, and (c) are happy with their marital/cohabitating partner are most likely to report having “fatherlike” perceptions. These data do not support hypotheses that predict that family structure variables and chi...
SCM-10: tenth international workshop on software configuration management new practices, new challenges, and new boundaries

With its tenth anniversary, the SCM workshop series is “leaving behind” a long and successful past: although the tools, techniques, and processes developed over the last twenty years have proven to be extremely valuable, they are inadequate to address the rapidly changing practices that define the world of tomorrow. Exemplified by component-based software development, open source, virtual enterprises, a ubiquitous use of XML, and the increasing dynamic nature of software, these new practices bring new challenges that necessitate dramatic changes to the field of CM.
Error exponents for multitone frequency shift keying on wideband Rayleigh fading channels

Flash signalling (with vanishing duty cycle) frequency shift keying (FSK) is known to be a capacity-achieving modulation for multipath fading channels in the limit of infinite bandwidth. However, since capacity-achieving schemes using flash FSK build the richness of their codebooks in frequency, the data rates of such schemes increase slowly with bandwidth. We seek to establish schemes that exhibit better performance than flash FSK for large but finite bandwidth. We consider multitone FSK, which we have shown in our previous work that can also achieve the infinite-bandwidth capacity limit for multipath fading channels, but is more general than FSK. Given its increased generality vis-a-vis FSK, and its optimality from a capacity point of view, multitone FSK is a good candidate for transmission over very wide bandwidth. In this paper, we discuss upper and lower bounds of error probabilities for the family of multitone FSK in Rayleigh fading channels. We find that these two bounds coincide in the infinite bandwidth limit and are therefore asymptotically tight. We compare the error probabilities of FSK and multitone FSK in different situations and conclude that FSK is the preferable scheme when average power is the biting constraint, and multitone FSK may be preferable when peak power is a limiting factor. We also explore the relationship among capacity and parameters related to time efficiency and spectrum efficiency.
Charcot arthropathy of shoulder: a case report

Neuropathic (Charcot) arthropathy is a degenerative disorder caused by decreased sensory and proprioceptive innervation of the involved joint 1 . It was first described by Jean‐Marie Charcot in patients with tabes dorsalis 2 . This type of arthropathy has many different underlying etiologies, including diabetes mellitus, tabes dorsalis, multiple sclerosis and syringomyelia 3 , 4 . The commonest presentation of neuropathic joint is secondary to diabetes mellitus, usually affecting the ankle 1 . Cases in the upper extremity are more likely to be due to syringomyelia 1 , 4 , where neurologic compromise leads to rapidly progressive joint destruction 5 . Syringomyelia is a progressively degenerative disorder of the spinal cord resulting in formation of an enlarging central cavity or syrinx 6 . The syrinx initially damages the pain and temperature fibers because they cross the midline; later it damages adjacent gray and white matter 6 , 7 . The patient often maintains motor function and proprioception 6 , 8 . Neuropathic arthropathy reportedly develops in up to one quarter of patients with syringomyelia, involving the upper extremity, usually the shoulder or elbow, in the vast majority of those cases 9 , 10 , 11 , 12 . Syringomyelia is commonly associated with Type I Arnold‐Chiari malformation. This malformation is caused by migration of the tentorium cerebelli inferiorly from the foramen magnum, thus enlarging the fourth ventricle 6 , 13 . Syringomyelia develops in 75%–85% of patients with the Type I Chiari malformation 6 .
The Language of Implicit Preferences

Abstract Are attitudes affected by the language in which they are expressed? In particular, do individual preferences shift to accord with the cultural values embedded in a given language? To examine these questions, two experiments tested bilingual participants, administering the same test of implicit attitudes in two languages. In both studies, participants manifested attitudes that favored social categories associated with the test language, e.g. more pro-Moroccan attitudes when tested in Arabic as compared with French (Study 1) and more pro-Spanish attitudes when tested in Spanish as compared with English (Study 2). The effects of language on elicited preference were large (mean d > .7), providing evidence that preferences are not merely transmitted through language but also shaped by it.
ULTRAVIOLET‐TRANSMITTING GLASSES FOR MERCURY‐VAPOR LAMPS*

The ultraviolet transmission of Vycor brand glass No. 791 is compared with that of certain commercial glasses and fused silica. The loss in transmission after 230 hours of exposure to ultraviolet radiation (2537 a.u.) from a Hanovia arc was 2.5% for No. 791 glass and 32.5% for Pyrex brand glass No. 9741. The loss (approximately 12%), due to the darkened layer which forms on a glass surface in contact with a mercury arc, is smaller for No. 791 glass than for glasses in general. The decrease in 2537 a.u. output of experimental lamps was determined after operation times up to nearly 6000 hours; after 5000 hours, No. 791 glass showed 27% loss in hot cathode lamps and Pyrex brand No. 9741 showed 53%. Vycor brand glass No. 7911, developed for medium-pressure arcs (such as sunlamps), is discussed. The electrical properties of Vycor brand No. 791 are resistivity at 350°C., 9.2 (log R, ohm-cm.); loss factor at 1.0 mc., 0.00091; and dielectric constant, 3.8.
Development of targeted therapies for triple-negative breast cancer: can we harness tumor heterogeneity to improve patient outcomes?

175 ISSN 1758-1923 10.2217/BMT.13.20 © 2013 Future Medicine Ltd Breast Cancer Manage. (2013) 2(3), 175–178 Triple-negative breast cancer (TNBC) is an aggressive breast cancer subtype defined by a lack of expression of estrogen receptor (ER), progesterone receptor (PR) and an absence of HER2 over expression. TNBC constitutes 15–20% of all breast cancers, although it is more common in young women, African–Americans and BRCA1 mutation carriers, and has an increased risk of metastatic recurrence and breast cancer-related death [1]. The poor prognosis of TNBC is related to the high likelihood of developing metastatic disease, the propensity for the involvement of visceral organs, such as the lungs and brain, with metastatic disease and the lack of effective, targeted, systemic anticancer therapies. TNBC represents a great challenge in the treatment of breast cancer despite a large body of research aimed at unraveling the biologic characteristics of TNBC and identifying those genomic features that separate it from luminal and HER2 breast cancers. Beginning with Perou et al. in 2000, gene-expression profiling has proved to be an effective tool for characterizing distinct breast cancer subtypes, including the basal-like group that segregates most closely with clinically defined TNBC [2]. This same technology was harnessed by Lehmann et al. in 2011 to further subdivide this basal-like group into six subtypes with differing patterns of dominant pathway expression [3]. This underlying hetero geneity within histopathologically defined TNBC represents a major challenge to developing more specific and effective targeted systemic therapies for TNBC, but also presents a great opportunity to develop targeted therapies with companion predictive biomarkers allowing enrichment for a responding population.
Designing Si-based nanowall arrays by dynamic shadowing growth to tailor the performance of Li-ion battery anodes

To target the low conductance and stress issues of Si anodes for rechargeable Li-ion batteries, we have systematically designed four unique Si nanorod-based anodes using a dynamic shadowing growth method. Multilayer Cu/Si and Cu side-coated Si nanorods serve to improve the conductance, meanwhile, uniform CuSi and composition-graded CuSi nanocomposites serve to relax the stress and increase the conductance. Under the identical charge/discharge conditions, both the uniform and graded CuSi composite nanostructures exhibit the best cycling performance with capacity retention of 60–80% after 100 cycles of Li-ion insertion and extraction. The morphology evolution reveals that the nanorod wall-like structures remain intact in the uniform and graded CuSi composite anodes, while they have peeled off from the current collectors in the intrinsic Si, multilayer Cu/Si, and Cu side-coated Si samples. The morphological changes of different Si-based nanoanodes have also been modeled by a beam network, revealing that Si-based composite nanostructures generate a low yield stress which could be the key to developing high performance Li-ion battery anodes.
A paracasting model for concurrent access to replicated content

We propose a framework to study how to download effectively a copy of the same document from a set of replicated servers. A generalized application-layer anycasting, known as paracasting, has been proposed to advocate concurrent access of a subset of replicated servers to satisfy cooperatively a client's request. Each participating server satisfies the request in part by transmitting a subset of the requested file to the client. The client can recover the complete file when different parts of the file sent from the participating servers are received. This framework allows us to estimate the average time to download a file from the set of homogeneous replicated servers, and the request blocking probability when each server can accept and serve a finite number of concurrent. requests. Our results show that the file download time drops when a request is served concurrently by a larger number of homogeneous replicated servers, although the performance improvement quickly saturates when the number of servers used increases. If the total number of requests that a server can handle simultaneously is finite, the request blocking probability increases with the number of replicated servers used to serve a request concurrently. Therefore, paracasting is effective in using a small number of servers, say, up to four, to serve a request concurrently.
Overthrowing the ‘Monopoly of the Pulpit’: Race and the Rights of Churchwomen in Nineteenth Century America.

This essay explores the dynamics of church, women’s rights, and race that animated Tanner’s commentary by focusing on two key chapters in the history of women’s rights in the nineteenth century. The first is the end of the 1840s, a moment frequently associated with the inaugural women’s conventions held in Seneca Falls and Rochester, New York. This essay reframes those conventions by examining a contemporaneous campaign for church women’s rights being waged in black Methodist churches. The second is the 1870s, a period often understood as shaped by disagreements over the terms of the Fifteenth Amendment and a resulting rupture of an antebellum woman’s rights–abolitionist coalition. Here, this moment is recast through consideration of how African American church women injected the question of women’s rights into debates over black Methodist law and polity in the wake of the Amendment’s ratification. In both cases, black and white women generally worked apart from one another, with lines of denomination and of race dividing their movements. They did share, however, a critical vantage point that centered on churches as contested terrain and church women as among the activists in a women’s movement. There is little question that these activist women were mindful of one another, even as social distance led to diluted or distorted understandings. All these women were covered in the spray of women’s rights. Standing at separate places along the seashore, they waded into confrontations that gave their discrete campaigns broad-reaching significance. Whether all women who called for the rights of church women were part of one wave is difficult to say until we recall that any wave is the by-product of many cross-currents.
Porosity Effects on the Thermoelectric Properties of Nanostructured Bismuth

Bismuth nanocrystals were synthesized using a polyol process and densified using spark plasma sintering to form polycrystalline bulk materials with uniformly dispersed nanoscale grains. The Bi nanocrystals were consolidated at different pressures in order to investigate the magnitude and temperature dependence of transport properties as a function of porosity. We also compare these transport properties with those of single-crystal bismuth. This investigation expands our understanding of the role of porosity in the thermoelectric properties of nanostructured bismuth.
Evaluation of biliary tract disease by diagnostic ultrasound

Diagnostic ultrasound is useful in evaluation in biliary tract disease because it is independent of function, rapidly performed, and noninvasive. In most cases the presence or absence of obstruction as well as the etiology of the obstruction can be made.
Analysis of Power Quality Monitoring Data and Research of Typical Comprehensive Treatment Program for Zhe-gan Electrified Railway

Through the analysis of the data obtained by the open power quality monitoring system for Zhe-gan electrified railway,from on macroscopic the overall trends of power quality in substations along the electrified railway is evaluated.According to the actual situation and field measurement data,the comprehensive treatment program is proposed,which solves power quality problems respectively from two aspects of voltage and current,at the same time based on the system equivalent network,a detailed design method of compensation system capacity is proposed.Simulation results show the efficiency of the program.The conclusions will be good for the design and implement of such kind of systems.
Esophagoscopy as a source of Pseudomonas aeruginosa sepsis in patients with acute leukemia: the need for sterilization of endoscopes.

A fortuitous series of clinical events led to a review of the culture reports and clinical records of all Baltimore Cancer Research Center patients undergoing endoscopy with a flexible fiberoptic esophagoscope in use since July, 1972. Of 12 such patients, 3, with acute leukemia, grew, from endoscopic cultures of esophageal washings and/or tissue, serotypes of Pseudomonas aeruginosa never previously recovered from the patient despite extensive, twice weekly cultures of nose, throat, axilla, perirectal area, and urine. Esophageal mucosal biopsy was performed at the time of endoscopy in 2 of these 3 patients. Each was severely granulocytopenic and in both patients fatal pseudomonas septicemia followed endoscopy, 12 hr and 3 days later. Cultures of the esophagoscope and of the endoscopy room revealed widespread contamination by enteric organisms, including Pseudomonas aeruginosa, and routine handling of the instrument ignored aseptic technique. Endoscopy, particularly with biopsy, in the compromised host carries the dual risk of inducing sepsis from endogenous flora and of introduction of invasive nosocomial organisms, especially Pseudomonas aeruginosa.
A modified thoracoabdominal approach for retroperitoneal lymphadenectomy

A modified thoracoabdominal approach for radical retroperitoneal lymphadenectomy is described. In addition, this same incision is ideal for surgical access to the retroperitoneal structures. The primary advantage of this approach is full exposure of the retroperitoneum with minimal retraction by assistants and without entering the chest cavity.
New Biology Inspired Anonymous Distributed Algorithms to Compute Dominating and Total Dominating Sets in Network Graphs

The selection mechanism of sensory organ precursor(SOP) from pre-neural cells of fruity fly has recently beenused to develop a new computing paradigm for probabilistic (randomized) distributed algorithms for graph theoretic primitiveslike maximal independent set (MIS) in networks [1]. The newparadigm is significantly different from the settings of traditionaldistributed algorithms [2], [3], [4], [5]: nodes are anonymous, the nodes do not need any knowledge of its neighbors, theyreceive binary message(s) from the neighbor(s), there is no needto decipher the message, only receipt or non-receipt of message(s) at any step of the algorithm. In this paper, we develop two newsimple distributed algorithms to compute the minimal dominatedset (MDS) and minimal total dominating set (MTDS) in a graphusing this new paradigm. We show that the two algorithmsfor computing the MDS and MTDS respectively converge withprobability (1 -- n½) using O(D log n) expected number of steps, where n is the number of nodes in the system and D is themaximum degree of a node. Preliminary experimental simulationresults show that the algorithms converge in substantially lessnumber of steps to converge than estimated by the analysis fora large number of graph families.
Pathways to Institutional Equilibrium after a Campus Disaster

This study applies theories of evolutionary organizational change to disaster-stricken higher education institutions. A collective case study was used to explore two institutions’ pathways back to operational equilibrium following environmental disasters. The key finding is the identification of seven variables that collectively influenced the institutional pathway to equilibrium. These variables can either shorten or lengthen the achievement of recovery goals that lead to operational equilibrium. The conclusion developed from these findings is that institutional equilibrium is largely dependent on external factors and can be regained while an institution is yet in recovery mode. Findings from this study contribute to the theoretical foundations of organizational development and crisis management, as well as the practice of crisis management in higher education.
A Proposta De Directiva Em Matéria De Segredos De Negócio – Uma Primeira Leitura (The Proposal for a Directive on Trade Secrets – A Preliminary Overview)

Portuguese Abstract:: Este artigo analisa sumariamente a proposta de directiva em materia de segredos de negocio a luz do direito portugues vigente.English Abstract: This article focusses on the pending proposal for a Directive on the protection of trade secrets. The proposal is analysed from a critical point of view, and some solutions regarding its transposition into Portuguese law are submitted.
Laminin: loss-of-function studies.

Laminin, one of the most widely expressed extracellular matrix proteins, exerts many important functions in multiple organs/systems and at various developmental stages. Although its critical roles in embryonic development have been demonstrated, laminin’s functions at later stages remain largely unknown, mainly due to its intrinsic complexity and lack of research tools (most laminin mutants are embryonic lethal). With the advance of genetic and molecular techniques, many new laminin mutants have been generated recently. These new mutants usually have a longer lifespan and show previously unidentified phenotypes. Not only do these studies suggest novel functions of laminin, but also they provide invaluable animal models that allow investigation of laminin’s functions at late stages. Here, I first briefly introduce the nomenclature, structure, and biochemistry of laminin in general. Next, all the loss-of-function mutants/models for each laminin chain are discussed and their phenotypes compared. I hope to provide a comprehensive review on laminin functions and its loss-of-function models, which could serve as a reference for future research in this understudied field.
Poster Abstract: BUFS: Towards Bottom-Up Foundational Security for Software in the Internet-of-Things

The Internet-of-Things (IoT) is a rapidly growing phenomenon. While IoT-enabled objects can provide rich features that can improve users' lives, security failures can lead to severe consequences, particularly in safety-critical domains such as medical devices and automobiles. In this poster abstract, we propose BUFS, a bottom-up and foundational approach for verifying the security of the software stack in an IoT system, to provide guarantees for how the software is secure. BUFS is a secure-by-construction approach that verifies that IoT software is secure in a bottom-up and foundational way. The BUFS approach provides tools for aiding and automating parts of the software development and verification process for programmers, and is intended for safety-critical domains, where high-assurance is required.
An Evidence-Based Approach to Conducting Systematic Reviews on CKD

With the growing need to integrate best evidence to inform clinical care, systematic reviews have continued to flourish. Although this type of review is integral to the synthesis of evidence-based information, systematic reviews are often conducted omitting well-established processes that ensure the validity and replicability of the study; elements of which are integral based on standards developed by the Cochrane Collaboration and the National Academy of Medicine. This review article will share best practices associated with conducting systematic reviews on the topic of CKD using an 8-step process and an evidence-based approach to retrieving and abstracting data. Optimal methods for conducting systematic review searching will be described, including development of appropriate search strategies and utilization of varied resources including databases, grey literature, primary journals, and handsearching. Processes and tools to improve research teams' coordination and efficiency, including integration of systematic review protocols and sophisticated software to streamline data management, will be investigated. In addition to recommended strategies for surveying and synthesizing CKD literature, techniques for maneuvering the complex field of Nephrology will also be explored.
Association of Metformin Use and Survival Outcome in Women With Cervical Cancer.

Objective Although preclinical studies suggest possible antitumor effects of metformin against cervical cancer, there is currently a lack of clinical data examining the association of metformin use and survival in women with cervical cancer. The aim of this study was to examine survival of women with cervical cancer who were receiving metformin. Methods This is a retrospective study examining consecutive cases of stages I to IV cervical cancer between 2000 and 2014. Patient demographics, medication use, tumor characteristics, treatment patterns, and survival outcomes were correlated to metformin use. Results There were 70 (8.9%; 95% confidence interval [CI], 6.9–10.9) metformin users and 715 nonusers identified for the analysis. Median follow-up time was 22.6 months. Recurrence/progression of disease and death due to cervical cancer were observed in 236 and 163 cases, respectively. Metformin users were more likely to be older, hypertensive, diabetic, and dyslipidemic compared with nonusers (all, P Conclusions In this study population, metformin use was not associated with survival of women with cervical cancer.
Guiding Patients Toward the Appropriate Surgical Treatment for Obesity: Should Presurgery Psychological Correlates Influence Choice Between Roux-en-Y Gastric Bypass and Vertical Sleeve Gastrectomy?

Helping patients determine which type of bariatric surgery, Roux-en-Y gastric bypass (RYGB) or vertical sleeve gastrectomy (VSG), may be the best treatment can be challenging. This study investigated psychological correlates and their influence on weight loss for patients who underwent RYGB or VSG. Four hundred twenty-two patients (RYGB = 305; VSG = 117) completed screening questionnaires presurgery and underwent surgery between August 2012 and April 2015. Associations between demographics and questionnaires with percentage weight change were evaluated using multivariable linear regression models. Median age was 48 years and median BMI 45.3 kg/m2 presurgery. Median percentage changes in weight from baseline to years 1 and 2 follow-up were − 31.5% (range − 52.2 to − 9.2%) and − 31.2% (range − 50.0 to − 1.2%) for RYGB and 25.3% (range − 49.8 to − 4.7%) and − 23.3% (range − 58.9 to − 1.6%) for VSG, respectively. Linear regression models revealed that younger patients lost more weight than older patients at years 1 (RYGB p < 0.0001; VSG p = 0.0001) and 2 (RYGB p = 0.005; VSG p = 0.002). No psychological correlates were significantly associated with weight loss outcomes. Post hoc analyses comparing patients who had surgery to those in the same cohort who did not have surgery revealed significantly higher rates of depression (p < 0.001), anxiety (p < 0.001), binge eating (p = 0.003), night eating (p < 0.001), food addiction (p = 0.042), and lower self-efficacy (p < 0.001) among patients who did not have surgery. Patients who are psychologically higher functioning are more likely to complete the evaluation process and undergo bariatric surgery. For patients who had surgery, psychological correlates were not associated with weight loss outcome for either RYGB or VSG. Implications for surgical choice are discussed.
An Objective Method to Accurately Measure Cardiorespiratory Fitness in Older Adults Who Cannot Satisfy Widely Used Oxygen Consumption Criteria.

Cardiorespiratory fitness (CRF) is routinely investigated in older adults; however, the most appropriate CRF measure to use for this population has received inadequate attention. This study aimed to 1) evaluate the reliability and validity of the oxygen uptake efficiency slope (OUES) as a sub-maximal measurement of CRF; 2) examine demographic, risk-factor, and exercise testing differences in older adults who satisfied standardized criteria for a peak oxygen consumption (VO2peak) test compared to those who did not; and 3) determine the difference between directly measured VO2peak values and OUES-predicted VO2peak values. One hundred ten enrollees from the Wisconsin Registry for Alzheimer's Prevention participated in this study. Participants performed a graded maximal exercise test and wore an accelerometer for 7 days. For each participant, the OUES was calculated at 75%, 90%, and 100% of exercise duration. VO2peak was recorded at peak effort, and one week of physical activity behavior was measured. OUES values calculated at separate relative exercise durations displayed excellent reliability (ICC = 0.995; p < 0.001), and were strongly correlated with VO2peak (rrange = 0.801-0.909; p < 0.001). As hypothesized, participants who did not satisfy VO2peak criteria were significantly older than those who satisfied criteria (p = 0.049) and attained a directly measured VO2peak that was 2.31 mL·kg·min-1 less than the value that was predicted by OUES VO2peak (p = 0.003). Older adults are less likely to satisfy VO2peak criteria, which results in an underestimation of their CRF. Without adhering to standardized criteria, VO2peak measurement error may lead to misinterpretation of CRF and age-related associations. Here, we conclude that OUES is a reliable, valid measurement of CRF which does not require achievement of standardized criteria.
MITRACLIP: ALTERNATIVE TREATMENT FOR HEMOLYTIC ANEMIA INDUCED BY MITRAL PARA-ANNULOPLASTY RING LEAK

Hemolytic anemia is a rare complications of mitral valve replacement or repair due to regurgitation around the prosthesis or annuloplasty ring. Percutaneous transcatheter techniques have been previously applied to the treatment of paraprosthetic valve leak. We report a case using MitraClip to treat
New Daily Persistent Headache (NDPH) & OnabotulinumtoxinA Therapy (P3.114)

Objective: To determine whether onabotulinumtoxinA therapy is effective in the treatment of New Daily Persistent Headache (NDPH). Background: New Daily Persistent Headache (NDPH) is a difficult to treat headache syndrome resistant to both conventional and unconventional headache therapies. NDPH was excluded in the registration trials for onabotunlinumtoxinA (onabot) in chronic migraine. Apart from case reports supporting its benefit, little is known about its therapeutic value in NDPH. Design/Methods: We performed a single center, retrospective chart review of patients with a diagnosis of NDPH who received onabot treatment over a 30 month period. Measures of interest were headache frequency and headache severity. After excluding patients seen at the Cleveland Clinic outside of the Headache Center, patients with missing data at baseline, patients that no longer had daily headache, and patients without valid data at any follow-up time point, there were 19 patients for frequency analysis and 14 for severity analysis. All patients had received the FDA-approved PREEMPT Protocol. Results: A decrease in headache frequency was noted in 8/16 (50.0%) patients at 6 months and 7/11 (63.6%) at 12 months. Using mixed effect logistic regression models, which account for loss-to-follow-up, the estimated percentage improving at 6 months was 49.7%, and at 12 months, 58.3%. Headache severity improved in 5/10 (50.0%) of patients at 6 months and in 7/9 (77.8%) at 12 months. Using mixed effect logistic regression models, the estimated percentage improving at 6 months was 50.0%, and at 12 months, 78.1%. Conclusions: Most therapies are unable to break the unremitting course of NDPH. In our investigation, at 1 year (3–4 cycles of onabot treatment), approximately half of the patients treated showed a reduction in headache frequency and approximately 75% demonstrated some improvement in headache severity. OnabotulinumtoxinA may be a reasonable choice in the treatment of NDPH, but a randomized controlled study should be the next step. Disclosure: Dr. Ali has nothing to disclose. Dr. Kriegler has received research support from Allergan. Dr. Tepper has received personal compensation for consulting, serving on a scientific advisory board, speaking, or other activities with Acorda, Alder, Allergan, Amgen, ATI, Avanir, BioVison, Charleston Laboratories, Dr. Reddy’s, electroCore, eNeura, Eli Lilly, GLG, Guidepoint Global, Kimberly-Clark, Pernix, Pfizer, Scion Neurostim, Supernus, Teva, Zosano. Dr. Vij has nothing to disclose.
Personalized Medicine and Anti-EGFR Antibody Therapy in the Treatment of Metastatic Colorectal Cancer: KRAS and Beyond

It was originally hoped that the presence of mutations in KRAS and other related genes would provide an easy answer as to whether to administer anti-EGFR antibody therapy to a given metastatic colorectal cancer patient. However, in nature nothing is simple, and there are a number of issues that practicing clinicians should be made aware of.
Introductory Fluid Dynamics Cases

The previous chapter featured several examples to illustrate each topic introduced (or just reviewed) in Sects. 2.2–2.5. They included 5 a few special cases of the conservation laws in both integral form [i.e., the simplified Reynolds Transport Theorem (RTT)] and differential form [i.e., the reduced Navier–Stokes (N–S) equations]. In this chapter, additional physical insight and a few new applications are provided, while problem-solving skills are honed in preparation for theories/models and applications in Parts B and C. Specifically, with 11 Sects. 3.4–3.7 four optional topics are included to better prepare students for the subsequent chapters, industrial demands, and/or post-graduate courses.
Management of Late Effects of Radiological Incidents

Radiological incidents refer to any incident, accidental or intentional, with exposure to radioactive material.
Reactive Oxygen and Reactive Nitrogen Species in the Lung

Reactive oxygen species (ROS) and reactive nitrogen species (RNS) have been implicated as contributing to the pathogenesis of a broad spectrum of diseases [1, 2]. Historically, oxygen free radicals were primarily considered to be aggressive species, indeed the superoxide (O 2 .- theory of oxygen toxicity is based on this hypothesis, (reviewed in 3). There is circumstantial evidence to support this view, some of which will be reviewed elsewhere in this chapter. However, other roles for free radicals — or more appropriately ROS and RNS — have recently emerged, most notably as signal or second messenger molecules. It seems therefore that these species can have differing effects which are dependent on their levels of production and on antioxidant defences. This chapter will mainly be concerned with the deleterious consequences associated with these reactive species, particularly in the lung, with special reference to acute lung injury (ALI) and acute respiratory distress syndrome (ARDS).
Rational Design of a Histidine-Methionine Site Modeling the M-Center of Copper Monooxygenases in a Small Metallochaperone Scaffold

Mononuclear copper monooxygenases peptidylglycine monooxygenase (PHM) and dopamine β-monooxygenase (DBM) catalyze the hydroxylation of high energy C-H bonds utilizing a pair of chemically distinct copper sites (CuH and CuM) separated by 11 A. In earlier work, we constructed single-site PHM variants that were designed to allow the study of the M- and H-centers independently in order to place their reactivity sequentially along the catalytic pathway. More recent crystallographic studies suggest that these single-site variants may not be truly representative of the individual active sites. In this work, we describe an alternative approach that uses a rational design to construct an artificial PHM model in a small metallochaperone scaffold. Using site-directed mutagenesis, we constructed variants that provide a His2Met copper-binding ligand set that mimics the M-center of PHM. The results show that the model accurately reproduces the chemical and spectroscopic properties of the M-center, including details of the methionine coordination, and the properties of Cu(I) and Cu(II) states in the presence of endogenous ligands such as CO and azide. The rate of reduction of the Cu(II) form of the model by the chromophoric reductant N,N'-dimethyl phenylenediamine (DMPD) has been compared with that of the PHM M-center, and the reaction chemistry of the Cu(I) forms with molecular oxygen has also been explored, revealing an unusually low reactivity toward molecular oxygen. This latter finding emphasizes the importance of substrate triggering of oxygen reactivity and implies that the His2Met ligand set, while necessary, is insufficient on its own to activate oxygen in these enzyme systems.
Sequest: A Sequential Procedure for Estimating Quantiles in Steady-State Simulations

Sequest is an automated sequential simulation-analysis procedure designed to provide improved point and confidence-interval (CI) estimators for a designated steady-state quantile by the use of batc...
The Virtue of Just Enough Stress: A Molecular Model

Molecular biology emphasizes the study of all-or-nothing phenomena and molecular events with a large dynamic range. However, many important physiologic parameters in the clinical setting are tightly constrained (e.g., serum sodium concentration, body mass, venous oxygen saturation, sleep duration). Stress responses exhibit both a wide dynamic range and a potential for important effects at a “just-enough” threshold activation level. Stress responses occur in a number of body systems (e.g., neuropsychiatric, immune, cardiovascular) and are essential for short-term damage control, but also must be tightly constrained in range and duration to permit the organism to walk the narrow homeostatic path to long-term survival. Using an example of a newly appreciated stress-responsive molecule in the heart, acetyltransferase p300, as well as examples from the literature, this article discusses the advantages of self-limited stress, the adverse effects of sustained stress, and the built-in mechanisms that feed back on and terminate stress signals, and advances a hypothesis regarding stress as a pharmacological target in the heart.
The Cutting Edge of Forensic Interviewing.

This article contextualizes new knowledge about forensically interviewing and assessing children when there are concerns about child abuse. The article references the impact of the Child Abuse Prev...
A New Experimental Facility for Characterizing Bladed Disk Dynamics at Design Speed

An experimental facility for structural dynamics programs that uses an above-ground containment tank specifically designed to house bladed disks operating at design speed is described in this work....
Optically Transparent Antennas: A Survey of Transparent Microwave Conductor Performance and Applications

Over the past 30 years, optically transparent conductors have revolutionized electronics in many televisions, smartphones, and solar panels. These conductors are materials that simultaneously allow the transmission of light and provide electrical conductivity [1]. Transparent conducting films (TCFs), the most widely used optically transparent conductor, are utilized in smartphone touch screens and flat-panel televisions, among other devices [2]. Since these deposited thin films are typically transparent in the visible spectrum, they can be deposited on aircraft windows to provide electromagnetic interference (EMI) shielding of aircraft electronics. Historically, these materials have been used primarily for applications in which optical transparency was required because a human was supposed to be able to see through the material easily (visible spectrum transparency) and electrical conductivity requirements were minimal since most applications were low frequency [3].
Fractura y resistencia en algunos cuentos misioneros de Horacio Quiroga

espanolEn los cuentos misioneros de Horacio Quiroga (1878-1937), ademas de recrear la complicada vida provinciana, se puede observar un interes por exponer la condicion de la selva. Esta es hostil, indomita y participe de los accidentes absurdos y la muerte tragica de los personajes. Estos cuentos no solo exponen el estado del campo y de sus moradores, sino tambien el futuro incierto de la sociedad. Esta narrativa pareciera sugerir que el destino de una nacion depende exclusivamente del estado de la naturaleza. Para esclarecer esta postura, este trabajo ubica la vida moderna en el centro de esta coyuntura, explorando como sus efectos sobre el orden natural del campo ocasionan una fractura irreparable entre la naturaleza y el hombre. Pese al tono pesimista de estos cuentos, este trabajo rescata posturas de resistencia que son consideradas como actos combativos que dejan un precedente de su enfrentamiento a la modernidad. EnglishIn addition to portraying the complicated life of the countryman, Horacio Quiroga s (1878-1937) Misioneros short stories depict the condition of the countryside. It is, indeed, a hostile, untamed place that plays a significant role in the absurd accidents and tragic deaths of the main characters. These short stories not only indicate the state of the countryside and its inhabitants, but also alert the readers of the unforeseeable future facing this society. In effect, the narrative of Misiones seems to suggest that the fate of this nation depends exclusively on the condition of nature. To clarify this stance, this article explores how the Argentinian modern life disrupted the natural order of the countryside, causing an irreparable rupture between the countryman and his natural surroundings. Despite of Quiroga s pessimistic views, we can find characters with strong critical attitudes which represent combative acts of resistance and confrontation to modernity.
Evaluating 239Pu(n,f) cross sections via machine learning using experimental data, covariances, and measurement features

Abstract The neutron-induced 239Pu fission cross section, 239Pu(n,f), is evaluated from 1–20 MeV using experimental data and associated covariances while also considering information on the measurement, termed features here. For instance, methods to determine the background, sample backing material, or impurities in the sample, are explicitly taken into account in the evaluation process. To this end, outliers in the experimental data are identified with a modified version of the Hybrid Robust Support Vector Machine. In a second step, two machine learning methods (logistic regression with elastic net regularization and random forest regression with SHAP feature importance metric) are used to highlight measurement features that are common among many of the outlying data points. Based on this analysis, penalty uncertainties are added to the experimental covariances of outlying data points that have outlier measurement features and are put through the generalized-least-squares evaluation. The resulting evaluated mean values and covariances differ distinctly from those data evaluated without the penalty uncertainties. These results highlight that certain measurement features should be more closely examined.
Effects of the SNAP25 on Integration Ability of Brain Functions in Children With ADHD

Objective:The present study aimed to examine the effects of SNAP25 on the integration ability of intrinsic brain functions in children with ADHD, and whether the integration ability was associated ...
Tension pneumocephalus and bilateral orbital compartment syndrome relieved by lateral canthotomies.

Abstract Traumatic tension pneumocephalus and orbital compartment syndrome are rare, tend to be associated with severe craniofacial injuries, and can occur following both blunt and penetrating injury. Early recognition and high index of clinical suspicion are important in both cases. Emergency decompression results in improvement in vast majority of cases.
Safety and Reactogenicity of 2 Doses of SARS-CoV-2 Vaccination in Solid Organ Transplant Recipients.

BACKGROUND: We studied the safety and reactogenicity SARS-CoV-2 mRNA vaccines in transplant recipients because immunosuppressed patients were excluded from vaccine trials. METHODS: US transplant recipients were recruited into this prospective cohort study through social media; those who completed the full vaccine series between 12/9/2020-3/1/2021 were included. We collected demographics, medical history, and safety information within 7 days after doses 1 and 2 (D1, D2). Associations between characteristics and reactions were evaluated using modified Poisson regression. RESULTS: We studied 741 transplant recipients who underwent BNT162b2 (54%) or mRNA-1273 (46%) vaccination. Median (IQR) age was 60 (44-69) years, 57% were female, and 10% were nonwhite. While local site reactions decreased after D2 (85% D1 vs. 78% D2, p<0.001), systemic reactions increased (49% D1 vs. 69% D2, p<0.001). Younger participants were more likely to develop systemic symptoms after D1 (adjusted incidence rate ratio [aIRR] per 10 years= 0.850.900.94, p<0.001) and D2 (aIRR per 10 years= 0.910.930.96, p<0.001). Participants who experienced pain (aIRR= 1.111.662.47, p=0.01) or redness (aIRR= 1.833.928.41, p<0.01) were more likely to develop an antibody response to D1 of mRNA vaccines. No anaphylaxis, neurologic diagnoses, or SARS-CoV-2 diagnoses were reported. Infections were minimal (3% after D1, <0.01% after D2). One patient reported incident acute rejection post D2. CONCLUSIONS: In SOTRs undergoing mRNA vaccination, reactogenicity was similar to that reported in the original trials. Severe reactions were rare. These early safety data may help address vaccine hesitancy in transplant recipients.