cssi/SciSciGPT-SciSciNet huggingface dataset:
Direct patterning of mammalian cells onto porous tissue engineering substrates using agarose stamps

This paper describes simple, inexpensive, and potentially generic methodology for generating patterns of mammalian cells on porous scaffolds for tissue engineering using replica printing. Circular patterns (diameter: 200, 700, and 1000mm) of human osteoblasts were transferred directly from topographically patterned agarose stamps onto porous hydroxyapatite scaffolds or onto fibronectin-coated glass slides. The use of hydrogel stamps provided a ‘‘wet’’, biocompatible surface and maintained the viability of cells adsorbed on stamps during the patterning process. Stamps inked once with suspensions of cells allowed the repeated patterning of substrates. Direct stamping of human osteoblasts (and, potentially other mammalian cells) can be used to control the size, spacing, and geometry of patterns of cells printed on porous tissue engineering substrates. This approach may find use in controlling the spatial invasion of scaffolds, promoting the hierarchical organization of cells, and in controlling cell–cell interactions as a step in preservation of phenotypes of cells. r 2005 Elsevier Ltd. All rights reserved.
Investigation of fat content in market common carp (Cyprinus carpio) flesh during the growing season

Effects of supplemental feeding with cereals (rye, triticale, maize and the unsupplemental control group) on fat content in flesh of 3-year-old common carp (Cyprinus carpio) were the subject of study carried out at four ponds (Czech Republic, Central Europe) during the growing season. The main result was that supplemental feeding with cereals to the same energetic level was associated with varying growth and fat content in the flesh of common carp. At the end of the experiment, the stock of fish supplementally fed with maize was found to have the highest fat content (112.7 ± 15.6 g kg−1), while the lowest value of fat content was found in the control group (56.8 ± 9.4 g kg−1). The carps supplementally fed with rye were found to have a higher fat content (90.1 ± 19.0) than those supplementally fed with triticale (84.3 ± 15.7 g kg−1). Established average fat content values (except for maize) were at the level that indicate a high sensory quality of carp flesh during the whole growing season.
Transcatheter Tricuspid Valve-in-Valve Replacement Resulting in 4 Different Prosthetic Heart Valves in a Single Patient

![Figure][1] ![Figure][1] [Video 1][2] Right Anterior Oblique View Showing the 2 Mechanical Valves and the Bioprosthesis. ![Figure][1] [Video 2][3] Deployment of the Edwards Sapien Valve Into the Bioprosthesis in the Tricuspid Position From the Right Internal Jugular ![
Automatic TLM generation for C-Based MPSoC design

This paper presents a tool for automatic generation of transaction level models (TLMs)for MPSoC designs using only C-code and graphical capture. The MPSoC platform is captured as a graphical net-list of components, busses and bridge elements. The application is captured as C processes mapped to the platform components. Once the platform is decided, a set of transaction level communication APIs is automatically generated for each process. After the C code is input, an executable SystemC TLM of the design is automatically generated using our tool. This TLM can be executed using standard SystemC simulators for early functional verification of the design. Although, several TLM styles and standards have been proposed in the past, our approach differs in the fact that the designers do not need to understand the underlying SystemC code or TLM modeling style to verify that their application executes on the selected platform. Moreover, the platform can be easily modified and a new TLM for that platform can be automatically generated. Our experimental results demonstrate that for large industrial applications such as MP3 decoder and H.264, high-speed TLMs can be generated for a wide variety of platforms in a few seconds.
Radiation treatment planning techniques for lymphoma of the stomach.

Purpose: Involved-field radiation therapy of the stomach is often used in the curative treatment of gastric lymphoma. Yet, the optimal technique to irradiate the stomach with minimal morbidity has not been well established. This study was designed to evaluate treatment planning alternatives for stomach irradiation, including intensity-modulated radiation therapy (IMRT), to determine which approach resulted in improved dose distribution and to identify patient-specific anatomic factors that might influence a treatment planning choice. Methods and Materials: Fifteen patients with lymphoma of the stomach (14 mucosa-associated lymphoid tissue lymphomas and 1 diffuse large B-cell lymphoma) were categorized into 3 types, depending on the geometric relationship between the planning target volume (PTV) and kidneys. AP/PA and 3D conformal radiation therapy (3DCRT) plans were generated for each patient. IMRT was planned for 4 patients with challenging geometric relationship between the PTV and the kidneys to determine whether it was advantageous to use IMRT. Results: For type I patients (no overlap between PTV and kidneys), there was essentially no benefit from using 3DCRT over AP/PA. However, for patients with PTVs in close proximity to the kidneys (type II) or with high degree of overlap (type III), the 4-field 3DCRT plans were superior, reducing the kidney V 15 Gy by approximately 90% for type II and 50% for type III patients. For type III, the use of a 3DCRT plan rather than an AP/PA plan decreased the V 15 Gy by approximately 65% for the right kidney and 45% for the left kidney. In the selected cases, IMRT led to a further decrease in left kidney dose as well as in mean liver dose. Conclusions: The geometric relationship between the target and kidneys has a significant impact on the selection of the optimum beam arrangement. Using 4-field 3DCRT markedly decreases the kidney dose. The addition of IMRT led to further incremental improvements in the left kidney and liver dose in selected patients.
Effective Sensor Scheduling Schemes in a Sensor Network by Employing Feedback in the Communication Loop

In this paper, we consider a state estimation problem over a bandwidth limited network. A sensor network consisting of N sensors is used to observe the states of M plants, but only p les N sensors can transmit their measurements to a centralized estimator at each time. Therefore a suitable scheme that schedules the proper sensors to access the network at each time so that the total estimation error is minimized is required. We propose four different sensor scheduling schemes. The static and stochastic schemes assume no feedback from the estimator to the scheduler, while the two dynamic schemes, Maximum Error First (MEF) and Maximum Deduction First (MDF) assume such feedback is available. We compare the four schemes via some examples and show MEF and MDF schemes perform better than the static and stochastic schemes, which demonstrates that feedback can play an important role in this remote state estimation problem. We also show that MDF performs better than MEF as MDF considers the total estimation error while MEF considers the individual estimation error.
OPTICAL ACTIVITY AND ELECTRONIC STRUCTURE OF SOME TRANS(DIACIDO)TETRAMINE COBALT(III) COMPLEXES

Abstract Electronic spectra for the trans(diacido)tetraminecobalt(III) complexes (anions may be glycinato, acetato R- or S.-alaninato, and the tetramine may be either 4,7-diaza-1,10-decanediamine (3,2,3-tet) or 4,7-diaza-5-methyl-1, 10-decanediamine (5-me-3,2,3-tet)) may be fit to a point charge model with D q xy =24.9 kK and D q z2kK; the pseudo tetragonal 1 A 1g – 1 A 2g and 1 A 1g – 1 E g transitions may therefore be assigned with some certainty. In the true lower symmetry of these complexes, the 1 E g state is split into two components. Regional rules predict a negative major CD component for trans(diacido)((–)-5-me-3,2,3-tet)cobalt(III) complexes while two components of opposite, but approximately equal rotatory strength have been observed. In this series of complexes, optical activity may be induced along a ‘tetragonal’ axis, within a ‘tetragonal’ plane, or both. The 1 A 1g–1 A 2g transition shows no rotatory strength for optically active centers on the z axis. Of the two bands observed in the regio...
The Presidential Surge and its Midterm Decline in Congressional Elections, 1868-1988

This note examines the effects of presidential elections on congressional elections. Nationally aggregated congressional seat and vote change data for the 61 congressional elections held in presidential and midterm election years from 1868 to 1988 are examined in a single-equation model. The results indicate strong presidential "surge and decline" effects. In presidential election years, a party's presidential vote positively affects its congressional election results--the presidential surge. In the following midterm elections, the president's party loses the advantage of the presidential surge and, as a consequence, also loses congressional votes and seats. These midterm losses of congressional seats and votes for the president's party are in proportion to the party's prior presidential vote margin. Presidential surge and decline effects, however, do not entirely explain vote and seat losses by the president's party in midterms. In addition to suffering vote and seat losses because of the absence of pres...
Arbitrarily dirty paper coding and applications

A deterministic dirty-paper coding strategy for communication over an arbitrarily varying channel with an interference signal known to the transmitter is investigated. The presence of a known interference signal at the transmitter is shown to provide some protection against jamming interference. For some values of the parameters the scheme is capacity- achieving. Applications to watermarking and spectrum-sharing channels are described.
Confirming the reliability of the sedation-agitation scale administered by ICU nurses without experience in its use.

Study Objectives. To determine the validity and reliability of the Sedation-Agitation scale (SAS) when administered by intensive care unit (ICU) nurses with no experience in its use. Design. Prospective, psychometric evaluation. Setting. Adult medical-cardiac ICU. Patients. Sixty patients. Intervention. Sedation and agitation were observed simultaneously but independently by nurses and two investigators, and patients were rated with the SAS. The assessment of an experienced clinical nurse specialist was recorded on visual analog scales (VAS) for sedation (VAS-S) and agitation (VAS-A). Measurements and Main Results. The SAS scores of ICU staff nurses were compared with VAS scored by the clinical nurse specialist using Pearson correlation coefficient. The SAS correlated well with VAS-S (Spearman's ρ = −0.77, p 0.5), but there were few observations of agitated patients. The SAS interrater agreement was excellent between the two trained investigators (weighted κ = 0.93, p<0.001) and between investigators and staff nurses (weighted κ = 0.85 and 0.87, p<0.001 for both). Conclusion. The SAS is reliable when administered by staff nurses with no experience with it. Due to the paucity of observations of agitated patients, we were unable to determine its validity for assessing agitation.
A Critical Path Approach to Analyzing Parallelism of Algorithmic Variants. Application to Cholesky Inversion.

Algorithms come with multiple variants which are obtained by changing the mathematical approach from which the algorithm is derived. These variants oer a wide spectrum of performance when implemented on a multicore platform and we seek to understand these dierences in performances from a theoretical point of view. To that aim, we derive and present the critical path lengths of each algorithmic variant for our application problem which enables us to determine a lower bound on the time to solution. This metric provides an intuitive grasp of the performance of a variant and we present numerical experiments to validate the tightness of our lower bounds on practical applications. Our case study is the Cholesky inversion and its use in computing the inverse of a symmetric positive denite matrix.
A 2D CMUT hydrophone array: Characterization results

As the use of ultrasonic transducers has increased so has the need to measure and characterize their pressure fields. Currently available hydrophones are limited by long scan times, and multiple source pulses to measure large area fields. Using a 2D capacitive micro-machined ultrasonic transducer (CMUT) array and associated electronics we are able to improve on these limitations. The CMUT inherently allows for a tunable sensitivity by changing DC bias. Motivated by the need to improve the characterization of megasonic cleaners used in semiconductor processing we were able to implement such an area hydrophone.
Testosterone's anti-anxiety and analgesic effects may be due in part to actions of its 5α-reduced metabolites in the hippocampus

Although testosterone (T) may have effects to enhance analgesia and reduce anxiety, its effects and mechanisms are not well understood. We hypothesized that if T's anti-anxiety and analgesic effects are due in part to actions of its 5alpha-reduced metabolite (dihydrotestosterone-DHT) and/or its 3alpha-hydroxysteroid dehydrogenase reduced metabolite (3alpha-androstanediol-3alpha-diol), in the hippocampus, then androgen regimens that increase levels of these metabolites in the hippocampus should produce anti-anxiety behavior, and analgesic effects, in gonadectomized (GDX) male rats. In Experiment 1, GDX rats were administered T, DHT, 3alpha-diol (1 mg/kg, SC), or vehicle. In Experiment 2, GDX rats had T, DHT, 3alpha-diol-containing inserts, or empty control inserts applied to the dorsal hippocampus immediately prior to behavioral testing. Androgen-administered rats (SC or intrahippocampal) showed significantly more exploratory behavior in the open field and elevated plus maze, less freezing in response to shock, and longer tailflick and pawlick latencies. These findings suggest that T's anti-anxiety effects may be due in part to actions of its 5alpha-reduced metabolites in the dorsal hippocampus.
Conservative modeling of 3-D electromagnetic fields, Part II: Biconjugate gradient solution and an accelerator

The preceding paper derives a staggered-grid, finite-difference approximation applicable to electromagnetic induction in the Earth. The staggered-grid, finite-difference approximation results in a linear system of equations Ax = b, where A is symmetric but not Hermitian. This is solved using the biconjugate gradient method, preconditioned with a modified, partial Cholesky decomposition of A. This method takes advantage of the sparsity of A, and converges much more quickly than methods used previously to solve the 3-D induction problem. When simulating a conductivity model at a number of frequencies, the rate of convergence slows as frequency approaches 0. The convergence rate at low frequencies can be improved by an order of magnitude, by alternating the incomplete Cholesky preconditioned biconjugate gradient method with a procedure designed to make the approximate solutions conserve current.
Examining the Role of the Communication Channel Interface and Recipient Characteristics on Knowledge Internalization: A Pragmatist View

This paper evaluates the role of reprocessability and symbol sets, two of the media capabilities identified in Media Synchronicity Theory, and different recipient characteristics on knowledge transfer. An experimental study manipulating the two specific channel interface characteristics was conducted to test the proposed model. Results indicate that symbol sets have a positive effect on knowledge possessed and knowledge applied. Motivation to learn significantly affected knowledge possessed and knowledge applied, while absorptive capacity was found to only influence knowledge possessed. The hypothesized relationships between reprocessability and knowledge internalization were marginally supported, and future research is suggested to address this issue.
At what age can children report dependably on their asthma health status

OBJECTIVE. This study examined psychometric properties and feasibility issues surrounding child-reported asthma health status data. METHODS. In separate interviews, parents and children completed 3 visits. Child questionnaires were interviewer administered. The primary instrument was the Children9s Health Survey for Asthma–Child Version, used to compute 3 scales (physical health, activities, and emotional health). The following were assessed: reliability (internal consistency and test-retest reliability), validity (general health status, symptom burden, and lung function), and feasibility (completion time, missing data, and inconsistent responses). RESULTS. A total of 414 parent-child pairs completed the study (mean child age: 11.5 years). Reliability estimates for the activities and emotional health scales were >.70 in all but 1 age category; 5 of 9 age groups had acceptable internal consistency ratings (≥.70) for the physical health scale. Cronbach9s α tended to increase with child age. In general, test-retest correlations between forms and intraclass correlation coefficients were strong for all ages but tended to increase with child age. Correlations between forms ranged from .57 (7-year-old subjects, physical health) to .96 (14-year-old subjects, activities). Intraclass correlation coefficients ranged from .76 (13-year-old subjects, emotional health) to .94 (15–16-year-old subjects, physical health). Children with less symptom burden reported higher mean Children9s Health Survey for Asthma–Child Version scores (indicating better health status) for each scale, at significant levels for nearly all age groups. Children9s Health Survey for Asthma–Child Version completion times decreased from 12.9 minutes at age 7 to 6.9 minutes at age 13. CONCLUSIONS. This research indicates that children with asthma as young as 7 may be dependable and valuable reporters of their health. Data quality tends to improve with age.
Sphericity and symmetry breaking in the formation of Frank–Kasper phases from one component materials

Frank–Kasper phases are tetrahedrally packed structures occurring in numerous materials, from elements to intermetallics to self-assembled soft materials. They exhibit complex manifolds of Wigner–Seitz cells with many-faceted polyhedra, forming an important bridge between the simple close-packed periodic and quasiperiodic crystals. The recent discovery of the Frank–Kasper σ-phase in diblock and tetrablock polymers stimulated the experiments reported here on a poly(isoprene-b-lactide) diblock copolymer melt. Analysis of small-angle X-ray scattering and mechanical spectroscopy exposes an undiscovered competition between the tendency to form self-assembled particles with spherical symmetry, and the necessity to fill space at uniform density within the framework imposed by the lattice. We thus deduce surprising analogies between the symmetry breaking at the body-centered cubic phase to σ-phase transition in diblock copolymers, mediated by exchange of mass, and the symmetry breaking in certain metals and alloys (such as the elements Mn and U), mediated by exchange of charge. Similar connections are made between the role of sphericity in real space for polymer systems, and the role of sphericity in reciprocal space for metallic systems such as intermetallic compounds and alloys. These findings establish new links between disparate materials classes, provide opportunities to improve the understanding of complex crystallization by building on synergies between hard and soft matter, and, perhaps most significantly, challenge the view that the symmetry breaking required to form reduced symmetry structures (possibly even quasiperiodic crystals) requires particles with multiple predetermined shapes and/or sizes.
Stalking in cyberspace

The Internet has revolutionized communication on a global level while creating a medium for stalking. Cyberstalking has emerged as a new form of stalking behavior. While 10 states have passed laws against electronic harassment, there has been great debate about whether electronic stalking constitutes criminal behavior or whether a perpetrator is entitled First Amendment protection. In the psychiatric literature to date, there are no studies of cyberstalking. This article focuses on relevant cases of stalking on the Internet. Specific legal issues associated with cyberstalking, such as boundary laws and freedom of speech, are examined. The psychological profile of the cyberstalker, as well as methods of intervention, are discussed.
Counseling the Fastest Growing Population in America: Those with Multiple Heritage Backgrounds

The multiple heritage (i.e., multiracial, biracial) population has been identified by the US Census Bureau as the fastest growing population in the US. With this growth, there is also the diversity of those in multiple heritage families and with multiple heritage backgrounds. In this article, the authors describe the challenges faced by this population, the individual identity development process, and ways of helping individuals at different developmental levels along with their families. There is also an introduction to the new Competencies for Counseling the Multiracial Population (Kenney et al., 2015).
Abstract A93: Genetic variations in aging related genes/pathways and colorectal cancer risk

Advanced age is arguably the most important risk factor for developing cancer. About 77% of all cancers are diagnosed in individuals 55 years of age and older. Aging is especially a dominant risk factor for colorectal cancer (CRC), with 91% of cases diagnosed in individuals 50 years of age and older. A number of genes and signaling pathways have been indicated in the aging process in model organisms including mammals, e.g. the insulin/IGF-1 signaling pathway, mTOR pathway and telomere and telomerase pathway. Recently, genome-wide association studies also identified several single nucleotide polymorphisms (SNPs) associated with longevity. Therefore, we hypothesized that genetic variations of the genes and pathways related to aging might be associated with CRC risk. We systematically identified 189 putative functional SNPs in 109 aging-related genes and 20 longevity-associated SNPs from GWAS. In the discovery phase, we genotyped these SNPs in 797 Caucasian CRC cases and 797 matched healthy control subjects. In main effect analysis, 10 SNPs were significantly associated with altered CRC risk. When evaluating combined effects of these SNPs, we found a significant gene dosage effect for increased CRC risk with increasing number of unfavorable genotypes. Compared with individuals carrying fewer than three unfavorable genotypes, individuals with six and more than six of these unfavorable genotypes exhibited a 2.06-fold (95% CI: 1.24-3.43, P = 0.006) and a 2.44-fold (95% CI: 1.76-3.38, P = 7.56×10 −8 ) increased risk of CRC, respectively (P for trend 1.25×10 −9 ). Higher order gene-gene interaction analysis also revealed potential relationships among SNPs in TP53 , ERCC2 , GPR133 , PRKAG3 , TEP1 , TSC1 and LMNA that further defined risk groups for CRC. Our results suggest that genetic polymorphisms in aging-related genes and pathways may modify CRC susceptibility both individually and jointly. Replication is currently underway to validate these findings. Citation Format: Fanmao Zhang, Cathy Eng, Moubin Lin, Michelle A.T. Hildebrandt, Yonggang He, Jie Lin, Maosheng Huang, Jian Gu, Xifeng Wu. Genetic variations in aging-related genes/pathways and colorectal cancer risk. [abstract]. In: Proceedings of the Eleventh Annual AACR International Conference on Frontiers in Cancer Prevention Research; 2012 Oct 16-19; Anaheim, CA. Philadelphia (PA): AACR; Cancer Prev Res 2012;5(11 Suppl):Abstract nr A93.
Reform in teaching of the electric circuit analysis course

The former fundamental department of Beijing Union University made experiments for the teaching reform of electric circuit analysis course in three classes of 99 semester of electric infomation and automation major. The aim of the reform was to explore the type of quality education in training students to posses of the innovatory spirit as well as innoratory ability. This paper presents some ideas and plans of the teaching reform, its result and its related teaching material construction as well.
Study on Testing Technology for Figure and Model Information Sharing between Master Station and Substation

On the basis of analyzing figure and model sharing technology between master station and substation,meanwhile combining present production and operation conditions and practical application of power system,this paper proposes specified contents of realizing model transformation testing,figure transformation testing,interactive communication testing and application scenarios simulation.In addition,it discusses development of simulation software for proceeding practical testing which is provided with good application effectiveness.
Stability of sheet flow of water beneath temperate glaciers and implications for glacier surging

A mathematical model is presented for the stability of sheet flow of water beneath a temperate glacier. Enhanced viscous heat dissipation in thick parts of the sheet tends to make sheet flow unstable, the instability increasing as sheet thickness and pressure gradient increase. However, incipient channels may be destroyed as the glacier slides over protuberances on its bed. Quasi-stable sheet flow may be possible for sheets up to several millimeters in thickness, especially beneath glaciers that have relatively gentle surface slopes and slide at moderate to high speeds. Such water sheets may somewhat reduce the effective roughness of glacier beds, but probably not enough to allow surge initiation. Furthermore, the presence of numerous water-filled cavities at the glacier bed will tend to reduce the sheet thickness and lessen the degree of “lubrication” of the glacier bed by the water sheet.
Theranostic near-infrared fluorescent nanoplatform for imaging and systemic siRNA delivery to metastatic anaplastic thyroid cancer

Anaplastic thyroid cancer (ATC), one of the most aggressive solid tumors, is characterized by rapid tumor growth and severe metastasis to other organs. Owing to the lack of effective treatment options, ATC has a mortality rate of ∼100% and median survival of less than 5 months. RNAi nanotechnology represents a promising strategy for cancer therapy through nanoparticle (NP) -mediated delivery of RNAi agents (e.g., siRNA) to solid tumors for specific silencing of target genes driving growth and/or metastasis. Nevertheless, the clinical success of RNAi cancer nanotherapies remains elusive in large part because of the suboptimal systemic siRNA NP delivery to tumors and the fact that tumor heterogeneity produces variable NP accumulation and thus, therapeutic response. To address these challenges, we here present an innovative theranostic NP platform composed of a near-infrared (NIR) fluorescent polymer for effective in vivo siRNA delivery to ATC tumors and simultaneous tracking of the tumor accumulation by noninvasive NIR imaging. The NIR polymeric NPs are small (∼50 nm), show long blood circulation and high tumor accumulation, and facilitate tumor imaging. Systemic siRNA delivery using these NPs efficiently silences the expression of V-Raf murine sarcoma viral oncogene homolog B (BRAF) in tumor tissues and significantly suppresses tumor growth and metastasis in an orthotopic mouse model of ATC. These results suggest that this theranostic NP system could become an effective tool for NIR imaging-guided siRNA delivery for personalized treatment of advanced malignancies.
The i-TTM model for ab initio-based ion–water interaction potentials. II. Alkali metal ion–water potential energy functions

A new set of i-TTM potential energy functions describing the interactions between alkali metal ions and water molecules is reported. Following our previous study on halide ion–water interactions [J. Phys. Chem. B, 2016, 120, 1822], the new i-TTM potentials are derived from fits to CCSD(T) reference energies and, by construction, are compatible with the MB-pol many-body potential, which has been shown to accurately predict the properties of water from the gas to the condensed phase. Within the i-TTM formalism, two-body repulsion, electrostatic, and dispersion energies are treated explicitly, while many-body effects are represented by classical induction. The accuracy of the new i-TTM potentials is assessed through extensive comparisons with results obtained from different ab initio methods, including CCSD(T), CCSD(T)-F12b, DF-MP2, and several DFT models, as well as from polarizable force fields for M+(H2O)n clusters with M+ = Li+, Na+, K+, Rb+, and Cs+, and n = 1–4.
Managing Data Frames

A data frame is the most common way of storing data in R and, generally, is the data structure most often used for data analyses. Under the hood, a data frame is a list of equal-length vectors. Each element of the list can be thought of as a column and the length of each element of the list is the number of rows. As a result, data frames can store different classes of objects in each column (i.e. numeric, character, factor). In essence, the easiest way to think of a data frame is as an Excel worksheet that contains columns of different types of data but are all of equal length rows. In this chapter I will illustrate how to create data frames, add additional elements to pre-existing data frames, add attributes to data frames, and subset data frames.
Power and the appeal of the deal: how consumers value the control provided by Pay What You Want (PWYW) pricing

The current research offers a number of novel findings regarding how individuals respond to Pay What You Want (PWYW) pricing, a strategy that affords consumers complete control over prices. Two experiments integrate research on consumer power into the PWYW literature to show that PWYW’s influence arises primarily with respect to low-power consumers who use PWYW’s pricing control to regulate their power states. Specifically, PWYW is shown to promote stronger intentions to purchase and to recommend a product than fixed pricing, particularly for low- versus high-power consumers. Supporting the notion that PWYW offers the powerless a platform for power elevation, experiment 2 reveals that the more favorable responses of low-power consumers to PWYW are accompanied by increased feelings of self-reliance. Further suggesting that low-power consumers value the pricing control afforded by PWYW for power regulation, the effects are not attributed to differences in the amounts that low- and high-power consumers are willing to pay under PWYW. In addition to providing a deeper understanding of PWYW pricing, the present work extends the power literature by demonstrating that power restoration can transpire not only from the possession of certain products but also through the pricing mechanism by which such products are obtained.
Immune checkpoint blockade for glioblastoma: Preclinical activity of single agent and combinatorial therapy.

2084 Background: Outcome for glioblastoma (GBM) remains dismal and innovative treatment strategies are desperately needed. Growing data support the contribution of local and systemic immune checkpoint molecules mediating immunosuppression by GBM tumors. Methods: Luciferized GL261 cells (GL261-Luc) were stereotactically implanted intracranially in albino C57BL/6 mice. Cohorts of mice with growing tumors (increasing bioluminescence) were treated with murine monoclonal antibodies (MAb) against PD-1, PD-L1, PD-L2, and CTLA-4 (single agent and combinations) every 3 days X 8 beginning 6 days following tumor implantation and were followed for overall survival. Subsets of mice underwent MRI as well as analysis of tumor infiltrating immune cells, and systemic immune cells and immunocytokines. Tumor re-challenge experiments were performed among long-term surviving mice. Results: Immune checkpoint blockade was well tolerated with no apparent morbidity or mortality among treated animals. Improved survival was noted a...
Association of Mohs Reconstructive Surgery Timing With Postoperative Complications

ImportanceSame-day Mohs reconstructive surgery is not always possible; moreover, a delay can offer benefits such as improved surgical planning and increased blood supply to the cauterized wound bed...
Lattice Effects on Charge Localization in Cuprates

Recent experimental results on cuprates and manganites, including those of elastic and inelastic neutron scattering measurements, suggest that charges are not homogeneously distributed even in the metallic state in these compounds. Charge inhomogeneity results from spin/lattice charge constriction. In cuprates the LO phonons strongly reflect the temperature- and composition-dependent charge inhomogeneity and may possibly be involved in causing it. Unlike the static stripes that compete against superconductivity, the charge inhomogeneity seen by the LO phonons is markedly increased in the superconducting phase. A new mechanism of high-temperature superconductivity involving lattice/spin charge constriction is proposed.
Examining motivational interviewing plus nutrition psychoeducation for weight loss in primary care

Abstract Objective Our previous randomized controlled trial found that nutrition psychoeducation (NP), an attention-control condition, produced statistically significantly more weight loss than usual care (UC), whereas motivational interviewing (MI) did not. NP, MI, and UC resulted in medium-large, medium, and negligible effects on weight loss, respectively. To examine whether weight loss could be further improved by combining MI and NP, the current study evaluated the scalable combination (MINP) with accessible web-based materials. Methods 31 adults with overweight/obesity, with and without binge-eating disorder (BED), were enrolled in the 3-month MINP treatment in primary care. Participants were assessed at baseline, post, and 3-month follow-up. Mixed-model analyses examined MINP effects over time and the prognostic significance of BED. Results Mixed-model analyses revealed that percentage weight loss was statistically significant at post and 3-month follow-up; d’ = 0.59 and 0.53, respectively. BED status did not predict or moderate weight loss. Twenty-one percent (6 of 28) and 26% (7 of 27) of participants attained 5% weight loss by post-treatment and 3-month follow-up, respectively. Participants with BED had statistically significantly greater improvements in disordered eating and depression (in addition to binge-eating reductions) compared to those without BED. Conclusion MINP resulted in weight and psychological improvements at post-treatment and through 3-months after treatment completion. There did not appear to be additional benefits to combining basic nutrition information with MI when compared to the previous randomized controlled trial testing nutrition psychoeducation alone. Clinical Trial Registration: NCT02578199 .
Integrative and collaborative care models between pediatric oral health and primary care providers: a scoping review of the literature.

Objectives Collaborative and/or integrative care between oral health and primary care providers can increase access to care to a more expansive population, helping to mitigate oral health related disease. The objective of this review was to present and evaluate different types of care models that exist between oral health and primary care providers in pediatric settings. Methods A literature search was conducted using five databases: MEDLINE/PubMed, ISI Web of Science, Dentistry and Oral Sciences Source, Cochrane Database, and EMBASE, to identify literature from January 1990 to January 2016. Combinations of controlled terms were utilized. Eligible sources targeted pediatric populations ages 1-17 and provided descriptions of existing collaborative and/or integrative models. Results Data related to the practice model, oral care provided, level of integration/collaboration and workflow were extracted. Sixteen articles were included that discussed 24 models of collaboration. These models provided ranges of services, but each offered a minimum of oral health risk assessment, oral health instruction, topical fluoride application and assessment for further treatment. These models included different levels of collaboration based off a ranking system created by the authors with 16.6 percent (4) classified as low, 54.2 percent (13) as medium and 29.2 percent (7) as high. Conclusions Existing care models offered varying services and levels of integration and/or collaboration, but each offered a baseline of oral care. Most of these collaborations were based within Federally Qualified Health Centers and aimed to ease access to care issues.
Principal Functions on Harmonic Spaces

In this chapter we shall discuss the problem of finding on a given harmonic space a harmonic function which imitates the behavior of a given harmonic function on a neighborhood of the ideal boundary of the harmonic space.
Metabolic Changes Following Cortical Contusion: Relationships to Edema and Morphological Changes

Rats with contusion injury to the right cortex exhibited significant formation of edema 6 and 24 hours after injury which resolved by 8 days and was replaced by cavitation necrosis. The contusions produced hyperglycolysis and ischemia in the impacted cortical tissue and underlying hippocampus immediately through 30 minutes post-injury. Glucose utilization was depressed throughout the contused cortex and in ipsilateral subcortical regions, as was blood flow, at chronic (1 and 10 days) periods after injury.
Is the incidence of anaplastic thyroid cancer increasing: A population based epidemiology study

Abstract Objective To provide an understanding of the incidence of anaplastic thyroid cancer within the United States. Methods Patients in the Surveillance, Epidemiology, and End Results (SEER) database were included from 1973 to 2014 based on a diagnosis of anaplastic thyroid cancer using ICD O-3 codes. Patients were categorized into cohorts based on their year of diagnosis. Results 1527 patients were diagnosed with anaplastic thyroid cancer within the SEER 18 registries. The age-adjusted incidence rate was 0.2 per 1,000,000 people (95% CI: 0.0–0.5) in 1973 and was 1.2 per 1,000,000 people (95% CI: 0.8–1.6) in 2014 (average annual percent change: 3.0% [95% CI: 2.2%–3.7%]). Patients tended to be of older age (mean age: 70.5 [range 15.0–102.0]), of female sex (62.8%), and Caucasian (81.1%). Finally, survival over time remained the same, as median disease specific survival months was 4.00 (95% CI: 2.26–5.74) from 1995 to 1999 and 4.00 (95% CI: 3.26–4.74) from 2010 to 2014. Conclusions The incidence rate of anaplastic thyroid cancer has increased from 1973 to 2014. Interestingly, median survival in months did not greatly change overtime. Based on this increasing incidence, physicians must act appropriately to identify patients with anaplastic thyroid cancer as it possesses a high morbidity and mortality. Level of evidence 4.
Regulation by Prosecutor

Prosecutors exercise broad power and nearly unchecked discretion. A distinctive and underappreciated aspect of prosecutorial authority lies in the ability to impose plea terms that effectively ensconce the prosecutor as a regulator. This phenomenon is clearest in corporate settlements mandating prospective changes to internal governance subject to ongoing prosecutorial review. Prosecutorial control of corporate governance, however, represents merely an extension of a longstanding practice. Prosecutors have often demanded prospective and remedial terms to resolve a wide array of criminal cases, including traditional cases against individuals. Such terms include bars from employment, compelled apologies, and bans from public office. Regulation by prosecutor is a predictable consequence of expansive criminal laws, the practical realities of plea bargaining, and the perceived failure of regulators; as such, it is unlikely to change. The question remains whether and how it might be governed. This Article represents a first step toward describing the breadth of the phenomenon, identifying its benefits and costs, and considering paths forward.
Depressive symptoms among adult children caregivers in China: moderating effects of working status and gender

Objectives: With over one-fifth of the world’s older population, shrinking family size and increasing number of women in the workforce, elder care is a growing challenge for families in mainland Ch...
Descriptive analysis of injuries and illnesses self-reported by wildland firefighters

Wildland firefighters working in remote environments with steep terrain, uneven ground, variable temperatures and fluctuating elevations cultivate injury risk. The purpose of this study was to understand types of injuries and illnesses wildland firefighters (WLFFs) sustain during the fire season. This study was a web-based cross-sectional questionnaire titled Injury surveillance of wildland firefighters. A total of 284 WLFFs responded to the questionnaire, but were not required to answer every question. Quantitative data from the questionnaire were analysed to determine WLFF demographics, types of injuries and illnesses sustained, and the potential influence environmental factors have on injuries sustained. Most WLFFs sustained at least one injury or illness in the past five fire seasons with a majority of those injuries and illnesses occurring on the fireline on rocky mountainside terrain. Nearly half of the 453 injuries and illnesses reported were sprains and strains occurring to the lower back, knee and ankle. Twenty percent of WLFFs reporting injuries felt that their injury or illness was preventable. With most injuries and illnesses occurring on the fireline, the development of a more targeted, job-specific injury and illness prevention program that focuses on the lower extremities is warranted.
The mixed kidney cell-lymphocyte culture reaction in rats

Publisher Summary This chapter discusses mixed kidney cell-lymphocyte culture reaction (MKLC) in rats. It describes an experiment that was conducted to find out if kidney specific antigens stimulate allogeneic lymphocytes in MKLC. The responding lymphocytes were obtained from the cervical lymph nodes and the stimulating cells from either the spleen or the kidney. The kidney cut into pieces was magnet stirred at 37°C in culture medium containing 0.1% trypsin for 60 minutes. The result suggests that allogeneic lymphocytes are stimulated by kidney cells in the absence of passenger lymphocytes. The stimulation is kidney specific when MLC and Ag-B are identical. The kidney specific antigenic determinant is trypsin dependent.
Adaptive Unknown Input and State Observers

Adaptive schemes for unknown input and state estimation are proposed for a class of uncertain systems with bounded unknown inputs. First, using a Lyapunov approach, conditions are derived that ensure the state and unknown input estimation errors converge to zero for a constant unknown input. Next, combining a Lyapunov approach and linear matrix inequalities, conditions are given that guarantee a prescribed performance level for state and unknown input estimation for a bounded not necessarily constant unknown input.
[Pathogen spectrum and epidemic status of major human parasites in Chenzhou City, Hunan Province].

OBJECTIVE To understand the pathogen spectrum and epidemic status of major human parasites in Chenzhou City, Hunan Province, so as to provide the evidence for parasitic diseases control. METHODS The survey sites were selected by the stratified cluster sampling method. The intestinal helminthic eggs were detected by Kato-Katz technique. The trophozoites or cysts of intestinal protozoa were detected by saline smear and iodine staining methods. The eggs of Enterubius vermicularis of children from 3 to 6 years old were detected by the cellophane anal swab method. The species of hookworm were identified by the filter paper strip culture method. RESULTS A total of 7 031 people were detected with the intestinal helminthic infective rate of 1.83% (129 cases). The major parasite was hookworm and there was a statistically significant difference of the infection rates among various parasites (χ2 = 107.77, P < 0.01). All the hookworm larvae were Necator americanus. No intestinal protozoon was detected. There were statistically significant differences of the infection rates among the counties (χ2 = 25.77, P < 0.01). The age of the patients was mainly focused on 30 and above years old and the infection rate was increased with the growth of age (χ2 = 26.21, P < 0.01). Farmers were the main population of the patients and there was a statistically significant difference of the infection rates between farmer and others (χ2 = 29.67, P < 0.01). CONCLUSIONS The infection rates of parasites are low and hook-worm is the main parasite in the pathogen spectrum in Chenzhou City. However, the infection factors still exist, therefore, effective and scientific measures should be taken to consolidate the achievement.
The Bomb and After: Fantasies of Apocalypse and Decline

This chapter explores Britain’s relationship to the atomic bomb by charting its geopolitical standing in the larger Cold War, exploring where and how nuclear anxieties were represented on screen, and analyzing the allegories and fantasies that attended to such a feeling of national inadequacy and perceived decline. It surveys a wide range of film types, from newsreels to James Bond features, and looks at how ideas about war during this period migrate into other genres. The chapter focuses on a comparison between two films about atomic fear, one about the threat and experience of the bomb, and the other about its aftermath. Peter Watkins’s The War Game (1965) and Richard Lester’s The Bed Sitting Room (1969) are wildly different explorations of the same sets of anxieties.
Social Factors in Building a Theater Corpus

The two case studies in this book found significant syntactic differences in between FRANTEXT and the Digital Parisian Stage corpus, with large effect sizes. Are these differences due to social biases in the choice of theatrical texts for FRANTEXT, or the lack of availability of certain texts in the Digital Parisian Stage sample? When examined with one-way analysis of variation (ANOVA), differences in negation proved to have a significant relationship to both the genre of the play and the theater where it premiered. No significant relationship was found between differences in dislocation frequency and genre or theater, or between any of the linguistic variables and factors like gender, age and social class. A larger sample may indicate such relationships beyond the possibility of sampling error.
The State of Synthetic Biology Scholarship: A Case Study of Comparative Metrics and Citation Analysis

This chapter explores the current state of synthetic biology by applying a network/connectivity analysis to publications within the field in order to better understand the different disciplines and actors evaluating synthetic biology and where they are headed. Seven hundred twelve publications were identified through the Web of Science database, and a citation network was built through a text mining process in R. Each publication is classified based on its community of practice as either a (1) state of science, (2) products, (3) risk, (4) governance, or (5) ethical, legal, and social implications (ELSI), and interrelationships were identified across each community of practice. Then, centrality measures of indegree, outdegree, betweenness, and eigencentrality were calculated to show important and seminal nodes. Finally, the centrality measures were analyzed over time to determine critical publications within the citation network. The results show that state of science has the largest share of cited publications within each community of practice. Also, the network’s indegree centrality is highly correlated with eigencentrality, indicating that the most cited publications are also the ones that are connected to other highly cited publications. Furthermore, this chapter demonstrates that text mining is an applicable tool to extract references from publications, construct a citation network, and understand the structure of an emerging body of literature.