cssi/SciSciGPT-SciSciNet huggingface dataset:
Application of ATP bioluminescence method to characterize performance of bioaerosol sampling devices

In this study we developed and tested an adenosine triphosphate (ATP) bioluminescence-based protocol for rapid characterization of bioaerosol sampling devices when collecting bacterial aerosols. Initial calibration of the method was performed using commercially available ATP assays to quantify known bacterial biomass in liquid samples. Here, the relative luminescence units (RLUs) indicative of total ATP content was plotted against total bacterial counts obtained using acridine orange direct count epifluorescence microscopy. The developed calibration curves were used to evaluate the collection performance of a BioSampler (SKC Inc., Eighty Four, PA) when sampling Pseudomonas fluorescens and Bacillus subtilis bacteria at three different sampling flow rates. The average collection efficiency for P. fluorescens and B. subtilis over all flow rates was 69% and 54%, respectively. Collection efficiencies determined by the ATP method for both bacteria at all flow rates agreed well (within 5%) with the acridine orange direct counts. Further, the ATP-based method allowed insights into the losses and fate of particles inside the sampling device. It was determined that a majority of losses occur in sampler's inlet. Such evaluation of losses is very difficult to perform using microscopy or culture-based techniques. Thus, the ATP-based technique could be reliably used as a tool for rapid and detailed evaluation of bioaerosol sampling devices.
Rheological characteristics of selected food gum mixtures in solution

The viscosity of pure and mixed dilute solutions of commercial alginate, carrageenan, guar gum, CMC and gelatin solutions at different mixing ratios were measured by a coaxial viscosimeter at different shear rates. The results are presented in the form of measured viscosity divided by the expected viscosity, if no interaction between the gums existed. This technique provides a clear demonstration of the existence of synergism or antagonism between the gums and helps in quantitatively assessing their extent.
The protection of a celebrity parody: Paris Hilton v. Hallmark Cards

This article focuses on the Hilton v. Hallmark decision issued by the 9th Circuit in 2009. Ultimately, the article criticises the ‘transformative use’ standard articulated by the California Supreme Court for evaluating right of publicity claims. Additionally, the article advocates for a more consistent standard which adequately balances celebrity interests with First Amendment free speech rights.
Marital Satisfaction and Passionate Love

One hundred married individuals completed questionnaires measuring marital satisfaction, passionate love, social desirability and six relationship-relevant variables - global happiness, relationship excitement, relationship boredom, sex-minus-arguments frequency, amount of shared activities and kissing frequency. Consistent with previous research, marital satisfaction had moderate to large correlations with the six relationship-relevant variables; for most variables, these correlations remained after partialing out passionate love and social desirability. For women, passionate love was moderately correlated with marital satisfaction and with the six relationship-relevant variables; for most variables, these correlations remained after controlling for marital satisfaction and social desirability. However, for men there were no significant correlations with passionate love.
Synthesis and X-Ray Structures of Ni(II) Complexes of 1-(2-Pyridinyl)Ethanone Oxime

Abstract A study of the complexation of Ni(II) with 1-(2-pyridinyl)ethanone oxime as a function of pH was carried out. A green complex, dibromobis(1-(2-pyridinyl)ethanone oxime)nickel(II), was isolated at pH 3. This octahedral complex (1) crystallizes in space group P21/n (a = 8.754(2), b = 11.136(3), c = 18.210(4) A, β = 92.18(2)[ddot], Z = 4) and has cis bromide ions (av. Ni-Br = 2.57(2) A), cis pyridine nitrogens (av. Ni-N = 2.091(9) A), and trans oxime nitrogens (av. Ni-N = 2.043(7) A). An orange octahedral complex, diaquo(1-(2-pyridinyl)ethanone oxime)(1-(2-pyridinyl)ethanone oximato)nickel(II) nitrate, (2) crystallized at pH 6 in space group P21/c (a = 12.497(3), b = 7.501(2), c = 20.940(5) A, β = 95.59(2)[ddot], Z = 4) and has trans water molecules (av. Ni-O = 2.069(5) A), cis pyridine nitrogens (av. Ni-N = 2.109(5) A, and cis oxime nitrogens (av. Ni-N = 2.037(6) A). Complex (2) has a short intramolecular hydrogen bond between oxime oxygen atoms (O…O = 2.524(3) A). A dark reddish-brown complex form...
Interaction of Hepatitis C Viral Proteins with Cellular Oncoproteins in the Induction of Liver Cancer

Hepatitis C virus infection is a major health problem all over the world. A large proportion of patients infected by HCV develop liver cirrhosis or cancer. However, the mechanism(s) remain to be elucidated. Since HCV does not carry any known oncogene, it is thought that interaction between virally encoded proteins and host proteins is responsible for carcinogenesis. Many crucial interactions between HCV-encoded proteins and host proteins have been reported. In this review we focus on the interaction of viral proteins with important regulators of cell cycle—oncoproteins YB-1, p53, and cyclin D1—which play a major role in cell proliferation, apoptosis, DNA repair, and genomic stability. Genetic variants of HCV accumulate in patients and alter these interactions of host cell proteins. It is a battle between the virus and host and the final outcome depends on the winner; if the host succeeds in clearing the virus the patient may not develop serious liver diseases. On the other hand, if the virus dominates by evolving quasispecies which code for altered proteins that interact differently with host proteins, or induce mutations in host protooncogenes, then the patient may develop liver cirrhosis and/or liver cancer.
The effectiveness of individual wellness counseling on the wellness of law enforcement officers.

The purpose of this exploratory study was to determine the effectiveness of wellness counseling on increasing wellness among law enforcement officers. The study also examined whether position in the Transtheoretical Model (J. O. Prochaska & C. C. DiClemente, 1982) and self-efficacy influenced the effectiveness of counseling on wellness. These findings indicate that counseling may increase wellness among law enforcement officers.
Dissociation of F2 by electron impact excitation of the lowest 3Πu electronic state

An ab initio theoretical study is reported for dissociation of F2 via excitation of the lowest 3Πu electronic state by electron impact. Differential and integrated cross sections are given for impact energies from 5 to 40 eV. Our distorted-wave model predicts a resonancelike feature in the integrated cross section near threshold with a maximum value of about 0.4×10^(-16) cm^2. When target polarization effects are included this feature disappears and the maximum cross section is reduced to about 0.15×10(^-16) cm^2.
The extension of data abstraction to database management

The long-term goal of the User Software Engineering (USE) project at the University of California, San Francisco, is to provide an integrated homogeneous programming environment for the design and development of interactive information systems. Realization of this goal involves the development of new software tools, their integration with existing tools, and the creation of an information system development methodology in which these tools are systematically used [1,2].The successful construction of interactive information systems requires the utilization of principles of user-centered design [3,4,5], combined with features traditionally associated with the separate areas of programming languages, operating systems, and data base management [6]. It has become increasingly clear that the key to being able to provide such a unified view lies in providing a unified view of data [7]. The potential benefits of such a unification are considerable, including:1) conceptual simplification of the system structure permitting, for example, joint design of data structures and data bases2) the elimination of duplication or inconsistencies among diverse software components3) the ability to achieve greater reliability in systems because of reduced dependence upon multiple software systems
Effect of 2-fluorohistidine labeling of the anthrax protective antigen on stability, pore formation, and translocation

The action of anthrax toxin relies in part upon the ability of the protective antigen (PA) moiety to form a heptameric pore in the endosomal membrane, providing a portal for entry of the enzymic moieties of the toxin into the cytosol. Pore formation is dependent on a conformational change in the heptameric prepore that occurs in the neutral to mildly acidic pH range, and it has been hypothesized that protonation of one or more histidine residues triggers this transition. To test this hypothesis, we used biosynthetic methods to incorporate the unnatural amino acid analogue 2-fluorohistidine (2-FHis) into PA. 2-FHis is isosteric with histidine but resists protonation at physiological pH values due to a dramatically reduced side-chain pKa (∼1). We found that 2-FHis-labeled PA was biologically inactive, as judged by its inability to deliver a model intracellular effector, LFN−DTA, to the cytosol of CHO-K1 cells. However, whereas 2-FHis blocked a conformational transition in the full-length PA83 protein in the...
Episodic nutrient transport to Florida coral reefs

This study documents the changes in nutrient fluxes associated with internal tidal bores arriving on Florida Keys coral reefs and points to biological use of subthermocline nitrate brought onshore by this mechanism. Internal bores on Conch Reef, Florida Keys, are associated with concentrations of 1.0‐4.0 mmol L 21 nitrate (NO ) and 0.1‐0.3 2 3 mmol L 21 soluble reactive phosphate (SRP) and onshore flow velocities of 0.1‐0.3 m s 21 . The arrival of internal bores causes 10‐40 fold increases in nutrient concentrations and 1‐2 orders of magnitude increases in nutrient flux relative to ambient, nonbore conditions. The magnitude and duration of cool-water nutrient transport events increases significantly with increasing depth on reef slopes. In June 2001, the gradient of increased exposure to subsurface water with depth corresponded to increased percentage of N and d 15 N and decreased C : N ratio in a common benthic macroalga, Codium isthmocladum.Internal tidal bores are widespread throughout the Florida Keys reef tract, with cool-water episodes influencing reefs up to 10%‐25% of the time during summer months and with significant variability among years. Estimated inputs of nitrogen and phosphorus by internal tidal bores to Florida Keys reef slopes are as much as 40-fold larger than published estimates of inputs to near-shore waters from waste water and storm water runoff. Internal tidal upwelling represents an important, previously underestimated, episodic source of nutrients on the Florida Keys reef tract. In order to assess nutrient availability in this system accurately it is essential to understand natural sources of high-frequency variability.
EGFR Kinase Regulates Volume-sensitive Chloride Current Elicited by Integrin Stretch via PI-3K and NADPH Oxidase in Ventricular Myocytes

Stretch of β1 integrins activates an outwardly rectifying, tamoxifen-sensitive Cl− current (Cl− SAC) via AT1 receptors, NADPH oxidase, and reactive oxygen species, and Cl− SAC resembles the volume-sensitive Cl− current (ICl,swell). Epidermal growth factor receptor (EGFR) kinase undergoes transactivation upon stretch, integrin engagement, and AT1 receptor activation and, in turn, stimulates NADPH oxidase. Therefore, we tested whether Cl− SAC is regulated by EGFR kinase signaling and is volume sensitive. Paramagnetic beads coated with mAb for β1 integrin were attached to myocytes and pulled with an electromagnet. Stretch activated a Cl− SAC that was 1.13 ± 0.10 pA/pF at +40 mV. AG1478 (10 μM), an EGFR kinase blocker, inhibited 93 ± 13% of Cl− SAC, and intracellular pretreatment with 1 μM AG1478 markedly suppressed Cl− SAC activation. EGF (3.3 nM) directly activated an outwardly rectifying Cl− current (0.81 ± 0.05 pA/pF at +40 mV) that was fully blocked by 10 μM tamoxifen, an ICl,swell blocker. Phosphatidylinositol 3-kinase (PI-3K) is downstream of EGFR kinase. Wortmannin (500 nM) and LY294002 (100 μM), blockers of PI-3K, inhibited Cl− SAC by 67 ± 6% and 91 ± 25% respectively, and the EGF-induced Cl− current also was fully blocked by LY294002. Furthermore, gp91ds-tat (500 nM), a cell-permeable, chimeric peptide that specifically blocks NADPH oxidase assembly, profoundly inhibited the EGF-induced Cl− current. Inactive permeant and active impermeant control peptides had no effect. Myocyte shrinkage with hyperosmotic bathing media inhibited the Cl− SAC and EGF-induced Cl− current by 88 ± 9% and 127 ± 11%, respectively. These results suggest that β1 integrin stretch activates Cl− SAC via EGFR, PI-3K, and NADPH oxidase, and that both the Cl− SAC and the EGF-induced Cl− currents are likely to be the volume-sensitive Cl− current, ICl,swell.
Flush-mounted dielectric-loaded axial slot on circular cylinder

The theory and numerical results for an axial slot antenna on a circular cylinder are presented. The slot and the cylinder have infinite length.
Measuring school health center impact on access to and quality of primary care.

Abstract Purpose School health centers (SHC) that provide comprehensive health care may improve access and quality of care for students; however, published impact data are limited. Methods We evaluated access and quality of health services at an urban high school with a SHC compared with a school without a SHC, using a quasiexperimental research design. Data were collected at the beginning of the school year, using a paper and pencil classroom questionnaire (n = 2,076 students). We measured SHC impact in several ways including grade by school interaction terms. Results Students at the SHC school were more likely to report having a regular healthcare provider, awareness of confidential services, support for health services in their school, and willingness to utilize those services. Students in the SHC school reported higher quality of care as measured by: respect for their health concerns, adequate time with the healthcare provider, understandable provider communications, and greater provider discussion at their last visit on topics such as sexual activity, birth control, emotions, future plans, diet, and exercise. Users of the SHC were also more likely to report higher quality of care, compared with either nonusers or students in the comparison school. Conclusions Access to comprehensive health services via a SHC led to improved access to health care and improved quality of care. Impact was measureable on a school-wide basis but was greater among SHC users.
Blood neutrophil activation markers in severe asthma: lack of inhibition by prednisolone therapy.

Neutrophils are increased in the airways and in induced sputum of severe asthma patients. We determined the expression of activation markers from circulating neutrophils in severe asthma, and their supressibility by corticosteroids. We compared blood neutrophils from mild, moderate-to-severe and severe steroid-dependent asthma, and non-asthmatics (n = 10 each). We examined the effect of adding or increasing oral prednisolone (30 mg/day;1 week). Flow cytometric expression of CD35 and CD11b, but not of CD62L or CD18, was increased in severe asthma. F-met-leu-phe increased CD11b, CD35 and CD18 and decreased CD62L expression in all groups, with a greater CD35 increase in severe asthma. In severe steroid-dependent asthma, an increase in prednisolone dose had no effect on neutrophil markers particularly CD62L, but reduced CD11b and CD62L on eosinophils. Phorbol myristate acetate-stimulated oxidative burst and IL-8 release by IL-1β, lipopolysaccharide and GM-CSF in whole blood from mild but not severe asthmatics were inhibited after prednisolone. There were no differences in myeloperoxidase or neutrophil elastase release from purified neutrophils. Because blood neutrophils in severe asthma are activated and are not inhibited by oral corticosteroids, they may be important in the pathogenesis of severe asthma.
A fuzzy technique for image segmentation of color images

Segmentation is one of the most important image processing steps towards image recognition and understanding. The largest area of an image can be easily segmented (crisp clusters), the association of most of the pixels to different clusters determined. It is the pixels between crisp clusters whose belongingness to adjacent clusters is not so clear. A pixel can belong to the closest cluster or in association with the neighboring pixels generate a new cluster. In this paper a fuzzy technique is presented which resolves these challenges. >
Effect of orthoses on postural stability in asymptomatic subjects with rearfoot malalignment during a 6-week acclimation period.

Abstract Mattacola CG, Dwyer MK, Miller AK, Uhl TL, McCrory JL, Malone TR. Effect of orthoses on postural stability in asymptomatic subjects with rearfoot malalignment during a 6-week acclimation period. Objective To determine the effect of custom-fitted orthoses on postural sway over a 6-week acclimation period. Design Repeated-measures analysis of variance on postural sway measures with factors being group (control, malaligned), time (initial, 2wk, 4wk, 6wk postintervention), and condition (with orthoses, without orthoses). For single-limb stance, side (right, left) was analyzed to determine bilateral differences. Setting Biodynamics laboratory. Participants Twenty-one subjects, 11 asymptomatic with rearfoot malalignment and 10 asymptomatic with normal rearfoot alignment. Interventions Orthoses were prescribed and worn for 6 weeks. Balance testing was performed on 4 different dates with each subject tested in both orthotic conditions. Postural control was measured with three 10-second eyes-closed trials for single-limb stance, one 20-second eyes-closed bilateral stance with the platform moving, and one 20-second eyes-open bilateral stance with the platform and surroundings moving. Main Outcome Measures Sway velocity (in deg/s) for single-limb stance and equilibrium score for bilateral stance. Results Postural sway measures were significantly decreased during single-limb testing with orthoses versus without orthoses, regardless of group. The orthotic intervention significantly improved bilateral stance equilibrium score in the malaligned group at weeks 2, 4, and 6 when compared with measures at the initial week. Equilibrium score of the malaligned group with orthoses at initial week was significantly lower (worse) than the control group with orthoses at initial week; however, these results were not repeated during measurements taken at weeks 2, 4, or 6. Conclusions The application of orthoses decreased sway velocity for single-limb stance, improving postural stability regardless of group when visual feedback was removed. During bilateral stance, postural stability was initially worse for the malaligned group with and without orthoses when compared with the control group; however, improvements were seen by week 2 and continued throughout the remainder of testing. Clinically, the application of orthoses appears to improve postural control in people with rearfoot malalignment, particularly when vision is removed.
Federal consistency and ocs oil and gas development: A review and assessment of the “directly affecting”; controversy

Abstract Attempts by the federal government, notably the Department of the Interior, to accelerate development of hydrocarbon resources on the Outer Continental Shelf have resulted in litigation between coastal states and the federal government. A principal issue involved has been whether federal consistency provisions contained in the Coastal Zone Management Act apply to federal lease sale decisions. Language contained in this statute (Section 307(c)(l)) requires federal activities directly affecting the coastal zone to be conducted in a manner consistent, to the maximum extent practicable, with state coastal zone management programs. This paper reviews the evolution of this controversy in intergovernmental relations since its inception, and describes various proposals which have been made to define the term “directly affecting.”; Events involved in OCS Lease Sales Nos. 48, 53, and 68, offshore California, are described to illustrate the varying state/federal perspectives on federal consistency requireme...
Radiographic and patient-based outcome analysis of different bone-grafting techniques in the surgical treatment of idiopathic scoliosis with a minimum 4-year follow-up: allograft versus autograft/allograft combination

Abstract Background context Autograft and allograft have been equally successful in achieving arthrodesis, but whether there is any difference in their effect on patient outcome, especially early, has not been determined. Purpose To determine if autograft in addition to allograft is associated with decreased healing period pain, increased early function, or both. Study design This is a retrospective comparative case series. Patient sample A sample of 47 patients, 20 years or younger with adolescent idiopathic scoliosis treated by the same surgeon at the same institution using third-generation segmental spinal instrumentation and arthrodesis. Outcome measure Function and pain were quantified at periodic intervals using the Scoliosis Research Society (SRS) health-related quality of life (HRQoL) questionnaire. Clinical and radiographic follow-ups were completed. Methods Freeze-dried corticocancellous allograft (AL) was used in 26 patients and allograft plus iliac crest autograft (AL-AU) in 21 patients. Radiographs and outcome measures, including SRS-24 or SRS-22 HRQoL questionnaires, were obtained preoperatively and at intervals with a 4-year follow-up available for 92% (25/26) of AL patients and 90% (19/21) of AL-AU patients. Results There were no differences between the AL and AL-AU groups’ ages, curve patterns, and complications. Neither group had a major complication or pseudoarthrosis. There were no main curve size differences at any interval. Pain scores were similar at all intervals: AL/AL-AU preoperative, 4.1/4.0; early follow-up ( 3 years), 4.1/4.0. Function scores were also similar at all intervals: AL/AL-AU preoperative, 4.7/4.6; early follow-up, 4.2/4.3; midterm follow-up, 4.9/4.9; and late follow-up, 4.5/4.4. Conclusions The addition of autograft to allograft did not result in decreased pain or increased function at any time interval up to 4 years. We conclude that the addition of iliac crest autograft does not result in any advantage over freeze-dried allograft alone in the treatment of adolescent idiopathic scoliosis.
Delayed partial liquid ventilation shows no efficacy in the treatment of smoke inhalation injury in swine.

In an earlier neonatal porcine model of smoke inhalation injury (SII), immediate postinjury application of partial liquid ventilation (PLV) had dramatic beneficial effects on lung compliance, oxyge...
The application of electrophysiology to research in alcoholism.

Recent findings from the application of electrophysiologic measurement techniques to research in alcoholism are reviewed. Computerized electroencephalography has detected subtle but significant differences in the information processing abilities of alcohol research subjects compared to control subjects. The differences may reflect the effects of a paternal history of alcoholism; the effects of acute, progressive, and chronic alcohol use; or the effects of abstinence following dependence on ethanol. Because they are revealed in several paradigms and across stimulus modalities, the electrophysiologic findings are robust. The results are clearest in response to visual stimuli and in tasks requiring active attention and evaluation of stimulus properties. Methodological and technical problems associated with the research are also reviewed. Language: en
Europe’s East-West Symposium on materials and processes

Held May 26-30, 1991, in Helsinki, Finland, MatTech '91 was the second conference in a series designed to promote the exchange of scientific and technological information on materials and processes and related areas between the communities of the East and West. In the present climate, this essentially meant a series of generally impressive presentations by the former Eastern Bloc countries on science and technology that they hope to license to the West.
Bone Formation in Heterotopic Implants of Kidney Tissue

Summary and ConclusionFrom these observations, we conclude:1. Fragments of kidney, implanted in subcutaneous tissue undergo coagulation necrosis similar to necrosis which supervenes after ligation of the renal artery. The necrosis may result from failure of the kidney to elicit a prompt vascular response in the surrounding tissue within the implant. Scattered fragments of pelvic transitional epithelium remain viable.2. Osteogenesis is observed in more than one-third of the implants as early as 14 days after implantation; yet the size of bone tissue is small at this time and a single section through the tissue may not disclose it.3. implantation of cortex alone results in no bone formation. The likely stimulus to bone formation is the transitional pelvic epithelium which is implanted along with the medulla.4. Implantation of kidney fragments in subcutaneous tissue seems to unify two previous models frequently used to study heterotopic osteogenesis; i.e., ligation of renal artery and transplanation of bladd...
El delito de parricidio: consideraciones críticas sobre sus últimas reformas (The Crime of Parricide: Critical Considerations Regarding the Latest Reforms)

Spanish Abstract: El articulo tiene por objeto analizar, desde una perspectiva critica, la configuracion actual del parricidio en Chile. Para ello, primero se ofrecera un breve repaso historico de la figura, resaltando las razones dogmaticas que han llevado a su supresion en el Derecho comparado. Acto seguido, desde un punto de vista conceptual y normativo, se analizan las categorias de violencia de genero, violencia domestica y femicidio, asi como la forma en que estas han penetrado en la estructura tipica del articulo 390 del Codigo penal chileno. A partir de ello, se expondra la critica de dos aspectos relativos a los sujetos del delito: la indeterminacion de la nocion de conviviente y la extension del tipo a los ex conyuges y ex convivientes. Finalmente, se revisaran otras consideraciones de indole politico-criminal que desaconsejan seguir ampliando la figura.English Abstract: This article aims to analyze, from a critical perspective, the current configuration of parricide in Chile. For this, first a brief historical overview of the crime will be presented, highlighting the theoretical reasons that have led to its elimination from Comparative law. Then, from a conceptual and normative perspective, the categories of gender violence, domestic violence, and femicide will be analyzed, as well as the manner in which they have penetrated the structure of article 390 of the Chilean Penal Code. From this, the critique of two aspects relative to subjects of this crime will be discussed: the indeterminacy of the notion of cohabiting partner and the increase in scope of the norm to include former spouses and former cohabitants. Lastly, other criminal policy considerations that discourage a further expansion of the crime will be reviewed.
Development of Mobile Apps for Wireless Sensor Data Acquisition and Visualization of Biopotentials

Pervasive health biomedical devices are presently trending towards supplementary usage with smart phones, tablets, and wearable gadgets to complement their ubiquitous roles in monitoring and diagnostic applications. In this paper, detailed design and development of a user-friendly mobile app using MIT App Inventor 2 software is explained, where emphasis is placed on building a graphical user interface (GUI) to provide the stage for real-time data acquisition and quality visualization (plotting) of photoplethysmography (PPG) data and their spectra on a smart device. Brief review of wireless networking and serial communications is also presented. PPG is modeled in a laboratory environment, where blood volume measurement is obtained via light absorption and reflectance through arterial pulse in the finger by an infrared LED source and optical sensor. A low-power microcontroller is implemented to control and digitize the analog PPG signal, characterized by a pulse oximeter waveform. Investigation of how this valuable biopotential data can be wirelessly transferred from the PPG device via a Bluetooth or WiFi module to a beaconing smart device is pursued. Following a research-driven approach and systematic process, the PPG raw data is amplified and filtered, transmitted and collected wirelessly, then further analyzed to derive the Heart Rate Variability (HRV) signal. Utilizing an advanced tool for studying the variability of heart beat intervals, namely Kubios software, the HRV data was validated for its accuracy in its computation and generation of quantitative markers indicative of the autonomic nervous system's (ANS) influence on the cardiovascular system, particularly the stress response.
Using transfer function approach to develop MRI visible and low RF heating sleeve for cardiac applicaion

A method is developed to evaluate the design of MRI visible and low heating catheter coating layer for cardiac and neuromodulation applications. The procedure consists of both experimental characterization of the coating layer as well as detailed electromagnetic simulation of human subject models during MRI procedure. Practical examples are used to demonstrate the effectiveness of this procedure.
Vanuit een nieuw ‘kijkraam’ werken met ouderen

De komende jaren gaat een nieuwe generatie ouderen een beroep doen op zorg- en dienstverlening. Veel van deze ouderen zijn mondig, hebben duidelijke voor- en afkeuren en zijn gewend om zelf richting te geven aan hun leven. Dit vraagt van professionals een radicale verandering in werkwijze: niet voor, maar met ouderen werken. Ofwel: co-creatie.
Sports Neurology in Clinical Practice: Case Studies

With regard to persistent posttraumatic headache, there is legitimate concern that duration of symptoms may have an impact on the efficacy of future treatment attempts. Without neuropathologic confirmation, a clinical diagnosis of chronic traumatic encephalopathy cannot be made with a high degree of confidence. Sport-related headaches are challenging in a return-to-play context, because it is often unclear whether an athlete has an exacerbation of a primary headache disorder, has new-onset headache unrelated to trauma, or is in the recovery phase after concussion. Regular physical exercise may prove beneficial to multiple neurologic disease states.
Anisotropic thermoelectric behavior in armchair and zigzag mono- and fewlayer MoS2 in thermoelectric generator applications.

In this work, we have studied thermoelectric properties of monolayer and fewlayer MoS2 in both armchair and zigzag orientations. Density functional theory (DFT) using non-equilibrium Green’s function (NEGF) method has been implemented to calculate the transmission spectra of mono- and fewlayer MoS2 in armchair and zigzag directions. Phonon transmission spectra are calculated based on parameterization of Stillinger-Weber potential. Thermoelectric figure of merit, ZT, is calculated using these electronic and phonon transmission spectra. In general, a thermoelectric generator is composed of thermocouples made of both n-type and p-type legs. Based on our calculations, monolayer MoS2 in armchair orientation is found to have the highest ZT value for both p-type and n-type legs compared to all other armchair and zigzag structures. We have proposed a thermoelectric generator based on monolayer MoS2 in armchair orientation. Moreover, we have studied the effect of various dopant species on thermoelectric current of our proposed generator. Further, we have compared output current of our proposed generator with those of Silicon thin films. Results indicate that thermoelectric current of MoS2 armchair monolayer is several orders of magnitude higher than that of Silicon thin films.
Primary Site as a Prognostic Variable for Children with Pelvic Soft Tissue Sarcomas

AbstractFrom 1974 to 1983 we treated 16 children between 1 and 16 years old for soft tissue sarcoma arising in the pelvis, bladder or prostate. An incisional biopsy was obtained in every patient. Each child then was treated with a combination chemotherapy program, incorporating vincristine, actinomycin D and cyclophosphamide with or without doxorubicin, cis-platinum and etoposide. Of the 16 patients 13 (81 per cent) also received radiation therapy.In 8 children with urinary obstruction or hematuria sarcomas arose in the bladder or bladder-prostate region, including 7 who had localized tumors and 1 who had lung metastases at diagnosis. The median tumor diameter in these patients was 5cm. Of these 8 patients 3 eventually required total cystectomy and prostatectomy to eradicate persistent local tumor, and 6 are alive and remain free of recurrent sarcoma for 1 to 9 years after initiation of therapy. The 8 other children had a pelvic mass at diagnosis, which arose adjacent to but outside of the bladder or pros...
Two Electrode Collector-Generator Method for the Detection of Electrochemically or Photoelectrochemically Produced O2

A dual working electrode technique for the in situ production and quantification of electrochemically or photoelectrochemically produced O2 is described. This technique, termed a collector-generator cell, utilizes a transparent fluorine doped tin oxide electrode to sense O2. This setup is specifically designed for detecting O2 in dye sensitized photoelectrosynthesis cells.
Breakthrough Fungal Infections after Allogeneic Hematopoietic Stem Cell Transplantation in Patients on Prophylactic Voriconazole.

Voriconazole is a triazole anti-fungal agent with excellent activity against Aspergillus spp. We use liquid itraconazole 200 mg PO twice daily from day 0 to a month beyond discontinuation of all immunosuppression as standard anti-fungal prophylaxis after allogeneic HSCT in patients with no prior history of aspergillosis. This is changed to PO voriconazole 200 mg twice daily if corticosteroid therapy is started for GVHD. Voriconazole is continued even after steroid therapy is discontinued. Patients with a past history of aspergillosis get voriconazole from day 0. 71 allograft recipients who received voriconazole, and in whom complete clinical, microbiologic, and pharmacokinetic data were available were studied to determine the efficacy of voriconazole in preventing invasive fungal infections (IFI). 17 patients had not received itraconazole previously. The remainder had received itraconazole for 1–161 days (median 14). The length of voriconazole therapy was 6–956 days (median 133). The total number of patient-days on voriconazole was 13805 (~38 years). A total of 10 IFIs were seen in patients on voriconazole: Candida glabrata (n=5), Candida krusei (n=1), Cunninghamella (n=1), Rhizopus (n=2), and Mucor (n=1). The figure below shows the actuarial probability of IFI − 18% at 1 year. ![Figure 1][1] Figure 1 It is noteworthy that while 4 cases of zygomycosis were seen, no case of Aspergillus infection was seen. The figure below shows the actuarial probability of zygomycosis − 7% at 1 year. Zygomycetes are generally not susceptible to voriconazole, and thus breakthrough infections are not surprising. However, C. glabrata and C. krusei are often susceptible to voriconazole with MICs of 2 μ g/mL (P=0.061; Fisher’s exact test). This observation is in keeping with a recent report that showed correlation between voriconazole levels and therapeutic success in aspergillosis (Smith et al. Antimicrob Agents Chemother 2006;50:1570–1572). We conclude that (1) voriconazole is extremely effective at preventing aspergillus infections, (2) zygomycosis is a concern in voriconazole-treated patients although the incidence appears low, and (3) therapeutic drug monitoring with dose adjustment may be indicated in patients on voriconazole to avoid breakthrough infections with fungi that are otherwise susceptible to the drug. ![Figure 2][1] Figure 2 [1]: pending:yes
Large benign de novo conjunctival hemangioma in an 11-year-old boy: case report and literature review

Benign hemangiomas are rare vascular tumors of the conjunctiva that typically present clinically in the first few weeks of life and resolve spontaneously. De novo presentation later in childhood has not been well documented. We present the unusual case of an 11-year-old boy with a rapidly growing benign de novo conjunctival hemangioma that was treated with surgical excision.
GENETIC ANALYSIS OF FITNESS TRAITS IN TUMOROUS-HEAD STRAINS OF DROSOPHILA MELANOGASTER.

N the spring of 1945, abnormal head growths were observed in some of the 'flies of a strain of D. melanogaster that had been collected in 1941, at Acahuizotla, Mexico, by field workers from the University of Texas. The strain was sent to the University of Utah in 1946, where it was named the tumorous-head strain (symbolized tu-h) and genetic studies were initiated. The genetic mechanism behind the abnormal growths consists of a third chromosome semidominant gene (tu-3) and a sex-linked recessive gene ( tu-?) responsible for a maternal effect. Flies of the tu-h strain are homozygous for these genes (GARDNER and WOOLF 1949). The penetrance (percent abnormal flies) in the tu-h strain when it arrived at the University of Utah in 1946, was 64 percent; after two years of selection it rose to 76 percent (NEWBY 1949). Genetic modifiers increasing the penetrance have been detected in laboratory and natural populations (GARDNER, STOTT, and DEARDEN 1952; GARDNER and GARDNER 1953). Penetrance is also influenced by temperature during an early developmental stage ( GARDNER and WOOLF 1950). Chromosomal dimorphism is present among the adults of this strain (WOOLF and PHELPS 1960). Two types of third chromosomes, symbolized by 3A and 3B, are present. The 3A chromosome contains tu-3 in the right arm, while 3B contains, in addition to tu-3, the Payne inversion (Zn(3L)P) and the recessive gene st (scarlet eyes) in the left arm. Since the 3B chromosome is homozygous lethal, the tu-h strain consists of homokaryotypes (3A/3A) and heterokaryotypes (3A/ 3B). These two different karyotypes are distinguishable on the basis of progeny tests. Heterokaryotypes, when mated with scarlet flies, yield scarlet and wildtype off spring, while homokaryotypes yield only wild-type off spring. Over 80 percent of the flies maintained in laboratory stock bottles and population cages are heterokaryotypes. This high frequency is mainly attributable to the significantly larger number of offspring produced by 3A/3B females (WOOLF and CHURCH 1963). Male and female heterokaryotypes are also more viable than homokaryotypes ( WOOLF and CHURCH 1963). The reduced productivity of female homokaryotypes is controlled by an interchromosomal genetic system
Resolving the 'innovation dilemma': corporate development of new technology–based product lines and businesses

The 'Innovation Dilemma' arises from the needs of most corporations eventually to develop major product lines and businesses that are distant from their current base strengths in markets and technologies. Yet their attempts to innovate are marked by high failure rate, especially in unrelated market–technology zones. An assessment of the major alternative strategies for technology–based business development highlights the strengths and weaknesses of each approach. 'The Familiarity Matrix' aligns these strategies with their appropriate use in seeking product line and business innovation.
Thermal evolution of a hyperextended rift basin, Mauléon Basin, western Pyrenees

Onshore and offshore geological and geophysical observations and numerical modeling have greatly improved the conceptual understanding of magma-poor rifted margins. However, critical questions remain concerning the thermal evolution of the prerift to synrift phases of thinning ending with the formation of hyperextended crust and mantle exhumation. In the western Pyrenees, the Mauleon Basin preserves the structural and stratigraphic record of Cretaceous extension, exhumation, and sedimentation of the proximal-to-distal margin development. Pyrenean shortening uplifted basement and overlying sedimentary basins without pervasive shortening or reheating, making the Mauleon Basin an ideal locality to study the temporal and thermal evolution of magma-poor hyperextended rift systems through coupling bedrock and detrital zircon (U-Th)/He thermochronometric data from transects characterizing different structural rifting domains. These new data indicate the basin was heated during early rifting to >180 °C with geothermal gradients of ~80-100 °C/km. The proximal margin recorded rift-related exhumation/cooling at ca. 98 Ma, whereas the distal margin remained >180 °C until the onset of Paleocene Pyrenean shortening. Lithospheric-scale numerical modeling shows high geothermal gradients, >80 °C/km, and synrift sediments >180 °C, can be reached early in rift evolution via heat advection by lithospheric depth dependent thinning and blanketing caused by the lower thermal conductivity of synrift sediments. Mauleon Basin thermochronometric data and numerical modeling illustrate that reheating of basement and synrift strata might play an important role and should be considered in the future development of conceptual and numerical models for hyperextended magma-poor continental rifted margins.
Território e acesso: Questões sobre as políticas de saúde

Este artigo tem o objetivo de discutir as articulacoes entre territorio e formas de acesso a saude, a partir da reflexao sobre as Politicas de Saude e o perfil epidemiologico que circunscrevem. Problematiza e coloca em analise alguns elementos para refletir sobre as praticas em saude a partir do campo das Politicas de Saude e do que estas produzem como modos de subjetivacao. O texto se apoia em uma perspectiva pos-estruturalista da Psicologia Social, focalizando principalmente as ferramentas conceituais foucaultianas. Parte-se da discussao sobre a relacao entre Politicas de Saude e perfil epidemiologico; a partir das consideracoes dessa relacao, articula-se a problematica do territorio e das formas de acesso. Com base nesses elementos, para finalizar a reflexao, intenta-se apontar algumas questoes que nos possibilitam pensar sobre o que o encontro das praticas em saude com o territorio produz de diferenca.
Impact of admission serum potassium on mortality in patients with chronic kidney disease and cardiovascular disease.

Background Little is known about the effect of admission potassium (K) on risk of in-hospital mortality in chronic kidney disease (CKD) and cardiovascular disease (CVD) patients. Aim The aim of this study was to assess the relationship between admission serum K and in-hospital mortality in all hospitalized patients stratified by CKD and/or CVD status. Design and methods All adult hospitalized patients who had admission serum K between years 2011 and 2013 were enrolled. Admission serum K was categorized into seven groups ( Results 73,983 patients were studied. The lowest incidence of in-hospital mortality was associated with serum K within 4.0-4.5 mEq/L. A U-shaped curve emerged demonstrating higher in-hospital mortality associated with both serum K 4.5 mEq/L. After adjusting for potential confounders, both serum K 5.0 mEq/L were associated with increased in-hospital mortality with ORs of 3.26 (95% CI 2.03-4.98), 2.40 (95% CI 1.89-3.04), 1.38 (95%CI 1.15-1.66), 1.89 (95% CI 1.49-2.38) and 3.62 (95%CI 2.73-4.76) when serum K were within Conclusion Admission serum K 5.0 mEq/L were associated with increased in-hospital mortality. The mortality risk among patients with various admission potassium levels was affected by CKD and/or CVD status.
Discard Estimates from Self-Reported Catch Data: an Example from the U.S. Northeast Shelf

AbstractDiscarded catch can account for a significant amount of fishing mortality and can be a major source of uncertainty when calculating total removals for stock assessments and management. Observers provide estimates on the types and quantity of fish that are caught, but observer coverage of a fleet can often vary directly with funding. On the Northeast U.S. shelf, the Northeast Fisheries Observer Program (NEFOP) has collected data on catch and discards for assessment and management purposes since 1989. The Cooperative Research Study Fleet (hereafter “Study Fleet”), working with the Northeast Fisheries Science Center, collects self-reported catch and discards from commercial vessels; however, the Study Fleet program was not developed as an observer program, and these data are not used for management. The number of vessels reporting data in the Study Fleet program is much smaller than the total number of vessels recorded through the observer program (NEFOP plus the At-Sea Monitoring Program), and unlik...
A pilot randomized aerobic exercise trial in older HIV-infected men: Insights into strategies for successful aging with HIV.

Background HIV-infected adults have increased risk for age-related diseases and low cardiorespiratory fitness that can be prevented and improved with exercise. Yet, exercise strategies have not been well studied in older adults with HIV and may require substantial adaptation to this special population. Objective To determine the safety and efficacy of aerobic exercise in older HIV-infected men in a randomized trial comparing different levels of exercise intensity. Methods We conducted a pilot exercise trial in 22 HIV-infected men ≥50 years of age receiving antiretroviral therapy who were randomized 1:1 to moderate-intensity aerobic exercise (Mod-AEX) or high-intensity aerobic exercise (High-AEX) that was performed three times weekly for 16 weeks in a supervised setting. Primary outcome was cardiorespiratory fitness (VO2peak) measured by treadmill testing. Secondary outcomes were exercise endurance, six-minute walk distance (6-MWD), body composition measured by Dual-energy X-ray absorptiometry (DXA), and fasting plasma levels of lipids and glucose. Results VO2peak increased in the High-AEX group (3.6 ±1.2 mL/kg/min, p = 0.02) but not in the Mod-AEX group (0.4 ±1.4 mL/kg/min, p = 0.7) with a significant between group difference (p<0.01). Exercise endurance increased in both the High-AEX group (27 ±11%, p = 0.02) and the Mod-AEX group (11 ±4%, p = 0.04). The 6-MWD increased in both the High-AEX (62 ±18m, p = 0.01) and the Mod-AEX group (54 ±14m, p = 0.01). Changes in VO2peak and 6-MWD were clinically relevant. There were no serious exercise-related adverse events. Dropouts were similar between group (27% overall) and were related to joint pain. Conclusions This pilot exercise trial demonstrates that moderate to high-intensity aerobic exercise in older HIV-infected men increases endurance and ambulatory function. However, increased cardiorespiratory fitness was observed only with high-intensity aerobic exercise despite substantial baseline impairment. Future research is needed to determine exercise strategies in older HIV-infected adults that address advanced aging and comorbidity yet are durable and feasible.