cssi/SciSciGPT-SciSciNet huggingface dataset:
Transoral laser microsurgery for carcinoma of the supraglottic larynx.

Objectives The study goal was to report the oncologic outcomes of transoral laser microsurgery (TLM) in the treatment of squamous cell carcinoma of the supraglottic larynx. Study Design and Setting A two-center prospective case series analysis. Results Thirty-eight patients underwent TLM for previously untreated carcinoma of the supraglottic larynx between 1997 and 2005. Pathological T stages were T1 in 8 (21%), T2 in 14 (37%), T3 in 8 (21%), and T4 in 8 (21%). Twenty-six patients (68%) had neck dissections. Thirteen patients (34%) received adjuvant radiotherapy. The mean follow-up for all patients was 31 months. The 2-year Kaplan-Meier estimates for local control were 97%; locoregional control, 94%; disease-specific survival, 80%; and overall survival, 85%. The overall functional laryngeal preservation rate was 79% (19 of 24). Conclusions TLM is a safe and effective treatment for cancer of the supraglottic larynx. Significance TLM is an emerging strategy in the management of laryngeal cancer.
Further results on the Aanderaa-Rosenberg conjecture

Abstract Some results on the “evasiveness” of graph properties are obtained, extending the work of Rivest and Vuillemin. In particular, it is shown that any nontrivial monotone graph property on n vertices is at least n 2 9 - evasive ; particular stronger results are obtained for values of n that are powers of primes less than 14. A new result allowing interpolation among n values is obtained, as are some stronger results on restricted classes of properties.
Some persistent issues of sociological polemics

The centrifugal forces and the jumble of polemics that have allegedly fragmented sociology today are shown to have existed also in the 1920s and the 1930s. The sharply contrasting visions of our field are illustrated in the debates among Ogburn, MacIver, Lundberg, and others. The logical analysis of certain persistent themes of intradisciplinary polemics shows them to be pseudo-issues—for example, differences in findings can be caused by differences in latent questions addressed by writers. From a cognitive point of view, the different approaches are frequently complementary rather than conflicting. The social conflict is caused by competition of various schools for scarce resources. This article proposes a two-pronged intellectual agenda that might clarify the complementarity of some orientations and strengthen the thrust towards theoretical integration.
Role of colorimetry and context in color displays

An experiment to quantify the effect of white point, black point, and surround color in color matching is presented. In this experiment, as in 'classical' colorimetry experiments, subjects are shown a color stimulus and are asked to adjust a parameter until a match is obtained. The stimuli used in this investigation consist of uniform color fields and continuous tone color images, whose white point, black point and surround color are varied. The results of this investigation are directly applicable to the display of images in a variety of displays and viewing conditions, for example, in the exchange of images among a variety of displays.
Transumbilical balloon angioplasty of subclavian artery thrombosis in a neonate.

We present a case of arterial thrombosis of the upper extremity in a 1-day-old neonate. The initial response to thrombolytic and anticoagulant therapy alone was unsuccessful. Distal flow to the extremity was reestablished by combined percutaneous transluminal angioplasty of the subclavian artery using transumbilical access followed by resumption of the thrombolytic and anticoagulant regimen. Cathet. Cardiovasc. Intervent. 49:56-60, 2000.
Nicardipine monotherapy in ambulatory elderly patients with hypertension

Abstract The antihypertensive effect of nicardipine was evaluated in 89 ambulatory elderly patients with hypertension through a multicenter trial enrolling patients over the age of 65 years. After a baseline period during which they recelved placebo, subjects were randomized by an unbalanced assignment to a double-blind comparison of nicardipine (n = 57) and placebo (n = 32). The initial dose of nicardipine was 20 mg every 8 hours, which was then increased to 30 mg if needed. Blood pressure and heart rate were measured 1 and 8 hours after doses at each visit with subjects in both the supine and standing positions. Seventy-six per cent of patients who received nicardipine and 55% who received placebo responded ( p
The origin of the far-infrared polarisation of liquid water

LIQUID water has a strong far-infrared polarisation. The origin of this has rarely been discussed in detail, although it causes the difference between the optical permittivity of about 1.8, and the limiting high frequency microwave (ɛ∞) permittivity of about 4.2. The phenomenon has been attributed by Zafar et al.1 to a high frequency relaxation of amplitude 2.4 in the permittivity, and a relaxation time of ∼ 50 ns resulting from the orientation of water molecules that are free of hydrogen bonds. Unfortunately, the authors did not apply Sherlock Holmes'2 adage that when you have eliminated the impossible, whatever remains, however improbable, must be the truth. Not all possible explanations of this polarisation have been considered and eliminated, although the correct one has been mentioned. There can be little doubt that there is, at present, no evidence for a new orientational relaxation.
Hall driven instability in ablating plasma

We consider the Hall effect in pulsed power generated plasma flows and its role in the creation of radial electric fields and plasma instability. We have developed a code based on the generalized Ohm's law plasma description that has allowed us to explore physics neglected by the resistive magnetohydrodynamic (MHD) model. We present simulation results of imploding Aluminum cylindrical wire arrays and plasma liners on the 1 MA COBRA machine, where both finite electron inertia and the Hall term are retained. The Hall effect introduces asymmetry into the system through plasma flows parallel to the liner surface, directed from the anode to the cathode. Simulations also show that inclusion of the Hall term delays the arrival of cathode precursor plasma to the geometric axis. Additionally, inclusion of the Hall term produces instability in ablating regions where the ion inertial length is of order one millimeter. This instability saturates at a constant wavelength, near the fundamental for Aluminum, and imprints itself into the precursor column.
Perioperative management of aspirin resistance after off-pump coronary artery bypass grafting: possible role for aprotinin.

Aspirin is the only drug proven to reduce saphenous vein graft (SVG) failure, but aspirin resistance (ASA-R) frequently occurs after off-pump coronary artery bypass grafting (OPCAB). The factors, mechanism, and best means for preventing and/or treating this acquired ASA-R have not been established. Thrombin production occurs during cardiac surgery despite heparin administration, with peak levels seen just after protamine administration.1,2 Although thrombin production is important for normal hemostasis, its excessive formation plays a pivotal role in the development of consumptive coagulopathy3 and thrombosis.4 Thrombin also induces a complete platelet (PLT) response during aggregometry despite aspirin use, suggesting its possible involvement in the mechanism of postoperative ASA-R. In vitro or animal models, however, are insufficient for understanding the complex interactions involved in the development of clinical ASA-R. The only study design capable of establishing the mechanistic link of ASA-R to early SVG failure is an adequately powered prospective clinical trial in humans. To date, though, no such study has been conducted. In a recent study, aprotinin administration during OPCAB was associated with reduced postoperative ASA-R compared with placebo.5 This study, however, was under-powered to show the effect of aprotinin on SVG failure or to address the mechanism of this intriguing effect on aspirin responsiveness. The prothrombin fragment F1.2 is an established marker of thrombin generation during cardiac surgery.2 In a previous report from an OPCAB cohort not given aprotinin, patients who developed SVG failure by Day 5 showed a sixfold increase in coronary sinus F1.2 levels just after protamine administration.6 Although the antifibrinolytic effects of aprotinin are emphasized, new evidence shows it can also modulate the thrombin burst after protamine use, in part via blockade of the PLT thrombin receptor PAR-1 (protease-activated receptor-1).7,8 The purpose of this interim analysis of our ongoing prospective cohort study was to compare patients who received aprotinin with those who did not receive antifibrinolytic therapy during OPCAB. We hypothesized that diminished perioperative thrombin formation in the aprotinin group is responsible for limiting the development of postoperative ASA-R and SVG failure.
A multi-component spatially-distributed model of two-phase flow for estimation and control of fuel cell water dynamics

The critical task of controlling the water distribution within the gas diffusion layer of a fuel cell suggests a partial differential equation (PDE) approach. Starting from first principles, the model of a fuel cell is represented as a boundary value problem for a set of three coupled, nonlinear, second-order PDEs. These three PDEs are approximated, with justification rooted in linear systems theory and a time-scale decomposition approach, by a single nonlinear PDE. A hybrid set of numerical transient, analytic transient, and analytic steady-state solutions for both the original and single PDE- based model are presented, and a more accurate estimate of the liquid water distribution is obtained using the single PDE-based model. The single PDE derived represents our main contribution on which future development of control, estimation, and diagnostics algorithms can be based.
Iron nanoparticles coated with amphiphilic polysiloxane graft copolymers: dispersibility and contaminant treatability.

Amphiphilic polysiloxane graft copolymers (APGCs) were used as a delivery vehicle for nanoscale zerovalent iron (NZVI). The APGCs were designed to enable adsorption onto NZVI surfaces via carboxylic acid anchoring groups and polyethylene glycol (PEG) grafts were used to provide dispersibility in water. Degradation studies were conducted with trichloroethylene (TCE) as the model contaminant. TCE degradation rate with APGC-coated NZVI (CNZVI) was determined to be higher as compared to bare NZVI. The surface normalized degradation rate constants, kSA (Lm2– h–1), for TCE removal by CNZVI and bare NZVI ranged from 0.008 to 0.0760 to 007–0.016, respectively. Shelf life studies conducted over 12 months to access colloidal stability and 6 months to access TCE degradation indicated that colloidal stability and chemical reactivity of CNZVI remained more or less unchanged. The sedimentation characteristics of CNZVI under different ionic strength conditions (0–10 mM) did not change significantly. The steric nature of...
Lightning in the North American Monsoon: An Exploratory Climatology

AbstractTemporal and spatial distributions of the North American monsoon have been studied previously with rainfall and satellite data. In the current study, the monsoon is examined with lightning data from Vaisala’s Global Lightning Dataset (GLD360). GLD360 has been operating for over three years and provides sufficient data to develop an exploratory climatology with minimal spatial variation in detection efficiency and location accuracy across the North American monsoon region. About 80% of strokes detected by GLD360 are cloud to ground. This paper focuses on seasonal, monthly, and diurnal features of lightning occurrence during the monsoon season from Mazatlan north-northwest to northern Arizona and New Mexico. The goal is to describe thunderstorm frequency with a dataset that provides uniform spatial coverage at a resolution of 2–5 km and uniform temporal coverage with individual lightning events resolved to the millisecond, compared with prior studies that used hourly point rainfall or satellite data...
Health Status and Access to Care for Homeless Adults with Problem Alcohol and Drug Use

Problem alcohol and drug use by adult homeless persons may put them at higher risk for other health problems and impact their access to health care. The purpose of this study was to determine if those with a positive screen for problem alcohol or drug use were at increased odds for having a lower health status and less access to care than those without problem alcohol or drug use. This was a secondary analysis of health survey data from a study related to the health of homeless adults. The survey included the Alcohol Use Disorders Identification Test (AUDIT) and the Drug Abuse Screening Test 10 (DAST-10) for evaluating problem substance use; health related quality of life, health care utilization, and medical history were also included. The impact of problem alcohol use or drug use on the odds of reporting lower general health status, a history of physical or mental illness, use of the emergency department (ED), and problems getting health care when needed, were estimated using logistic regression. A tota...
Improved waveform design for target recognition with multiple transmissions

This paper presents a matched waveform technique for target class identification, i.e., a multiple hypotheses testing (MHT) framework. This technique is shown to improve classification performance of SNR-based matched waveforms derived from a probability-weighted spectral variance (PWSV) approach. The technique, which allows for real-time adaptive waveform transmission, is also shown to be computationally efficient.
Actions of Solvable Algebraic Groups on Central Simple Algebras

Let k be an algebraically closed base field of arbitrary characteristic. In this paper, we study actions of a connected solvable linear algebraic group G on a central simple algebra Q. The main result is the following: Q can be split G-equivariantly by a finite-dimensional splitting field, provided that G acts “algebraically,” i.e., provided that Q contains a G-stable order on which the action is rational. As an application, it is shown that rational torus actions on prime PI-algebras are induced by actions on commutative domains.
High performance multi-channel data compression chip

This paper describes the architecture and implementation of the Data Compression Chip (DCC) for high-performance lossless data compression for multi-channel highspeed data networking applications. The DCC implements an improved adaptive string matching algorithm using a new parallel architecture-the Variable Length String Matcher (VLSM). The VLSM quickly performs an otherwise time-intensive string-matching procedure. Furthermore, by avoiding the typical data structures that require very large and fast memory to store a compression vocabulary, the DCC's VLSM minimizes system costs. By maintaining separate vocabularies for multiple channels, the DCC eliminates the loss of compression efficiency otherwise experienced in typical frame-multiplexed or reset-at-frame applications. The DCC uses a high-performance algorithm with a custom parallel architecture to minimize vocabulary memory (VRAM) requirements and provide very high throughput and compression efficiency for multiple channels. The device has been realized in 0.8 micron CMOS technology with a die area of 9.27 mm/spl times/10.0 mm and power dissipation about 1 W at 20 MHz. It employs a 160 pin PQFP package. >
Biologically active surfaces: Processes governing the formation and persistence of biofilms

Definition du terme «biofilm». Exemples ou la formation de biofilms est nefaste (biocorrosion, pathologie); exemples ou la formation de biofilms est souhaitee (immobilisation de cellules). Mecanismes de formation (nature du support, transport des cellules, depot, adhesion a la surface, metabolisme de la cellule aux depens du support, production de polymere extracellulaire). Destruction du biofilm (action d'un predateur, effet de cisaillement, abrasion...)
An Over-60dB True Rail-to-Rail Performance Using Correlated Level Shifting and an Opamp with 30dB Loop Gain

This work introduces correlated level shifting (CLS) that simultaneously decreases the error due to finite opamp gain and allows true rail-to-rail operation. An extra phase is needed, but, surprisingly, there is no speed penalty when compared to a high-gain opamp solution because CLS does not require full settling during the next-to-last phase. In fact, the increased signal swing means that the same SNR can be achieved using smaller sampling capacitors. Thus, it could be argued that CLS can provide accurate results at a higher speed than using a traditional 2-phase operation with a high-gain opamp. For example, with CLS, the performance is maintained over the whole 0.9V supply, whereas a standard configuration has only a 0.6V swing. Thus, the standard configuration requires 2.25x larger sampling capacitors to achieve the same signal to kT/C noise ratio.
Performance evaluation of 2-D adaptive prediction filters for detection of small objects in image data

This work studies the performance of dimensional least mean square (TDLMS) adaptive filters as prewhitening filters for the detection of small objects in image data. The object of interest is assumed to have a very small spatial spread and is obscured by correlated clutter of much larger spatial extent. The correlated clutter is predicted and subtracted from the input signal, leaving components of the spatially small signal in the residual output. The receiver operating characteristics of a detection system augmented by a TDLMS prewhitening filter are plotted using Monte-Carlo techniques. It is shown that such a detector has better operating characteristics than a conventional matched filter in the presence of correlated clutter. For very low signal-to-background ratios, TDLMS-based detection systems show a considerable reduction in the number of false alarms. The output energy in both the residual and prediction channels of such filters is shown to be dependent on the correlation length of the various components in the input signal. False alarm reduction and detection gains obtained by using this detection scheme on thermal infrared sensor data with known object positions is presented. >
Antecedents And Consequences Of Foreign Direct Investment And International Procurement Through A General Strategic Management Lens

Since multiple perspectives and dynamic national environments can be applied to explain how value is created in an international context, multinational firms need analytical guidelines when facing procurement and production decisions concerning various worldwide locations for valueadded chain activities such as marketing, production, distribution, and after sales service. The ultimate aim of this research was to abstract and empirically test a realistic but fairly simple localization framework to facilitate the design of an information system that supports a cost-benefit analysis based on legal requirements, value chain activities, and product costs. A balance was sought between inclusiveness and minimalism in the development of a normative model for implementation of dynamic strategic planning and control programs. The data show the participants’ behavior is significantly influenced by all three elements supporting the value-added localization model and validating the holistic approach put forth by Lecraw & Morrison (1991).
MINIMUM GROWTH TEMPERATURES FOR FOOD-POISONING, FECAL-INDICATOR, AND PSYCHROPHILIC MICROORGANISMS.

Publisher Summary The chapter aims to show which storage temperatures are sufficiently low to prevent growth of food-poisoning organisms, fecal indicators, and psychrophiles in frozen and chilled foods. These three groups of organisms are treated separately. Growth of the first group creates a health hazard; the presence of the second usually indicates fecal contamination; and the psychrophiles are not considered to be health hazards, but they cause deterioration and spoilage of foods even at temperatures considerably below 0°C. Of these three groups, the food-poisoning organisms and the fecal indicators are mesophiles. Many species of psychrophilic bacteria, yeasts, and molds can cause deterioration and spoilage of food a t 0°C and below. All of these are considered in determining the maximum storage temperature that will prevent microbial growth and consequent deterioration of foods. The chapter presents a compilation of available data listing the minimum temperatures at which these three classes of organism have been observed to grow. It discusses the relationship between environmental factors and minimum growth temperatures. It also considers the question of why there is, for a given organism under given conditions, a minimum temperature below which no growth is observed even after prolonged incubation. Each microorganism has a temperature minimum below which growth cannot be detected even after prolonged incubation in the presence of the nutrients that support growth at higher temperatures. Thus, the chapter considers several factors that may limit growth as the temperature is reduced.
Personality as a Campaign Moderator: The Big Five Facets and Political Mobilization

This paper argues that individual differences in the facets of conscientiousness lead some people to become better citizens and participate while driving others away from the process. In addition, the effects of these personality traits depends on the presence (or absence) of partisan, mobilizing campaign appeals. I argue that previous scholars of personality in politics find inconsistent results for the Big Five domain of conscientiousness not because of poor theory but rather because we have been measuring conscientiousness at the wrong level. When the multi-dimensional domain is broken down to its six uni-dimensional facets (competence, order, dutifulness, achievement striving, self-discipline, and deliberation), the predictions of these scholars are generally confirmed. Using two experiments designed to test the influence of personality facets in a dynamic political information environment, I show that the facets of dutifulness, achievement striving, and self-discipline perform as predicted, while competence, order, and (with one exception) deliberation provide little value in predicting political behavior. This paper extends current research on personality in political science to the study of political campaigns. When the domain of conscientiousness is measured at the facet level, personality drives some individuals away from politics while pulling others towards the process, and targeted mobilization campaigns exert both normatively positive and negative influences over this relationship.
CHAPTER 3: PHOSPHORUS-CONTAINING RESINS

Abstract “Resins” as understood in this chapter, are three-dimensional cross -linked plastics (thermosetting resins) which cannot be processed thermoplastically once they are cured. These resins are the oldest plastics known in history and still are of great commercial importance, especially in those areas of application which require
A new method for achieving enhanced dielectric response over a wide temperature range

We report a novel approach for achieving high dielectric response over a wide temperature range. In this approach, multilayer ceramic heterostructures with constituent compositions having strategically tuned Curie points (TC) were designed and integrated with varying electrical connectivity. Interestingly, these multilayer structures exhibited different dielectric behavior in series and parallel configuration due to variations in electrical boundary conditions resulting in the differences in the strength of the electrostatic coupling. The results are explained using nonlinear thermodynamic model taking into account electrostatic interlayer interaction. We believe that present work will have huge significance in design of high performance ceramic capacitors.
Computed Tomography of the Asymptomatic Postsurgical Lumbar Spine: Analysis of the Physiologic Scar

Computed tomography (CT) has been shown to be an effective noninvasive means of imaging the lumbar spine in patients with suspected disk disease. The clinical and radiographic evaluation, however, of patients with new or recurrent symptoms after surgery for disk disease is fraught with difficulty. This report describes CT changes seen in seven asymptomatic volunteers scanned at various intervals after disk surgery and discusses the implications of these findings.
Low Level Radiation Effects on Endothelial Cell Eicosanoid Biosynthesis

Radiation therapy of thoracic cancers often requires that normal pulmonary tissue be within the treatment (radiation) field (1). Consequently, radiation, In addition to killing tumor cells, often damages the vascular endothelium (2). Studies presented here were directed toward analysis of low dose radiation effects on pulmonary endothelial cell monolayers. We characterized low dose radiation (γ- radiation source, 137Cs, 100.4 cGy/min; x-radiation source, 203 cGy/min) induced changes in endothelial functions which we believe are responsible for post radiation lung injuries. Characterization included radiation effects on endothelial cell 12-lipoxygenase metabolism, and αvβ3 integrin receptor expression. Our data suggest that low dose radiation, at levels comparable to those used in fractionated and accelerated hyperfractionated radiotherapy, may alter the lipoxygenase metabolism, integrin expression and vascular integrity of the endothelial microvascular monolayer, and that these endothelial responses to radiation are the forerunners of post radiation lung injuries and may facilitate metastasis.
The Hexagon Quantum Billiard

A subset of eigenfunctions and eigenvalues for the hexagon quantum billiard are constructed by way of tessellation of the plane and incorporation of symmetries of the hexagon. These eigenfunctions are given as a double Fourier series, obeying C 6 symmetry. A table of the lower lying eigen numbers for these states is included. The explicit form for these eigenstates is given in terms of a sum of six exponentials each of which contains a pair of quantum numbers and a symmetry integer. Eigenstates so constructed are found to satisfy periodicity of the hexagon array. Contour read-outs of a lower lying eigenstate reveal in each case hexagonal 6-fold symmetric arrays. Derived solutions satisfy either Dirichlet or Neumann boundary conditions and are irregular in neighborhoods about vertices. This singular property is intrinsic to the hexagon quantum billiard. Dirichlet solutions are valid in the open neighborhood of the hexagon, due to singular boundary conditions. For integer phase factors, Neumann solutions are valid over the domain of the hexagon. These doubly degenerate eigenstates are identified with the basis of a two-dimensional irreducible representation of the C 6v group. A description is included on the application of these findings to the hexagonal nitride compounds.
Commentary on effect of radiosurgery alone vs radiosurgery with whole brain radiation therapy on cognitive function in patients with 1-3 brain metastases by Brown et al. JAMA 2016;316:401-9.

The team of Brown et al. are to be congratulated for the recent publication of a prospective randomized trial that evaluated cognitive function and tumor control in patients with 1–3 brain metastases (primarily lung).[1] This level 1 evidence provided additional confirmatory support regarding the role of stereotactic radiosurgery (SRS) as a primary management option for patients whose cancer has spread to the brain. The confirmation that SRS reduces the early cognitive function decline in cancer patients compared to the use of whole brain radiation therapy (WBRT) provides additional data that has gradually led to the displacement of reflex WBRT as the usual strategy for brain metastatic disease.
Multimodal Imaging of Myocardial Infarction in Mice

Transgenic and knockout mice are widely used to define the roles of individual genes in cardiovascular disease. In particular, magnetic resonance imaging (MRI) and ultrasound are valuable for assessing the response of the mouse heart to myocardial infarction (MI). The ability to assess the time evolution of changes in left ventricular (LV) volumes and function in mice enables investigators to elucidate the molecular mechanisms underlying both MI and heart failure. The pathophysiology of heart disease can further be probed using molecular imaging. Thus, examples of molecular and cellular imaging will be discussed relative to the long-term goal of fully integrating multimodal imaging of cardiovascular disease.
Identification of new susceptibility genes in familial breast cancer by exome sequencing.

1538 Background: Familial breast cancer was described in the early 1970s with its syndromy confirmed by the discovery of BRCA germline mutations in the 1990s. BRCA mutations account for less than 1...
Envy and scorn as primary markers of the pervasive antipathy in college football’s rivalry games: the University of Michigan as a representative microcosm

AbstractRivalry games – or derbies – are special. They involve emotions and identities that reach way beyond the playing field. This article submits that the emotional content and normative expression of college football rivalries in the United States are less defined by the respective teams’ actual athletic results in the competition but rather by their institutions’ perceived prestige as well as their social and cultural capital encapsulated by their academic ranking. Fans of the institution that is lower ranked in its academic status display envy towards their opponents representing an institution with higher academic ranking, whereas the latter express scorn for the former. They both hate each other but the nature of their respective hatred differs: envy up, scorn down. The paper analyses a bevy of college rivalries before focusing on two featuring the University of Michigan.
Imaging assessment of fibrodysplasia ossificans progressiva: Qualitative, quantitative and questionable

Fibrodysplasia ossificans progressiva (FOP) is an ultra-rare autosomal dominant genetic disorder of heterotopic ossification (HO) characterized by skeletal anomalies and episodic soft tissue swelling (flare-ups) that can transform into heterotopic bone. The progressive development of heterotopic bone and progressive arthropathy leads to significant limitation of mobility. This paper will review various imaging modalities used in evaluating episodic soft tissue swelling (flare-ups), heterotopic bone and skeletal anomalies. Different imaging modalities are required at different stages of the disease. Ultrasound and MRI can be useful for evaluating edema in early stages of a flare-up; MRI being superior to ultrasonography. Plain radiographs and computed tomography (CT) can evaluate heterotopic bone in later stages of HO, but CT scan is better at evaluating presence and the volume of heterotopic bone. Functional imaging demonstrates increased activity at sites of flare-ups, their utility in determining disease progression need to be further evaluated. Cost, radiation exposure, availability of various imaging modalities and the ability of FOP patients to fit in the scanner are all considerations when requesting radiographic tests in a patient with FOP. Future studies are required to determine if early radiographic findings can determine disease progression and response to treatment in this disorder.
Relations Between the Optical and Radio Properties of Extragalactic Radio Sources

Correlations between the radio and optical properties of radio sources have proved elusive and the main conclusion to be drawn from this is that there is a great variety of objects in the universe that emit nonthermal radiation, so that attempts to use these objects for cosmological purposes can be frustrated unless one can find some way of selecting objects that do have common intrinsic properties. Despite this, the search for relations and correlations is interesting quite apart from cosmology, because such correlations should provide a groundwork for a physical theory or theories of what is really happening in sources of nonthermal radiation.
Transactivator: A New Face of Arabidopsis AGO1.

Argonaute (AGO) proteins execute RNA-induced transcriptional and post-transcriptional gene silencing. In this issue of Developmental Cell, Liu et al. (2018) uncover a nuclear function for Arabidopsis AGO1 in positively regulating gene expression. AGO1, guided by small RNAs, binds to chromatin to induce target gene transcription in response to environmental stimuli.
A “good” new brand — What happens when new brands try to stand out through corporate social responsibility

Abstract Corporate social responsibility (CSR) is increasingly used as a key part of a firm's branding strategy, especially for new brands hoping to stand out in mature markets. Unfortunately, data here demonstrate that new product trial is lower when new brands tout CSR activity than when they do not. To understand this surprising phenomenon, we find CSR has a negative effect on new brands' perceived product performance. Happily, we find a fix for new brands; negative effects for new brands can be reversed if the company explicitly signals a priority for both the product and its CSR endeavors. Importantly, we do not see a similar negative impact of CSR on established brands.
Analysis of Product Designs for Product Recovery Using Linear Physical Programming

Internet of Things (IoT) can help in weighing in products’ designs for recovery when they are returned at their end of lives. Devices such as Radio Frequency Identification (RFID) tags and sensors can be embedded in products to store and collect information and determine their conditions at the end of their lives, which can then be used to choose a rational recovery process amongst disassembly, remanufacturing, recycling and disposal. This paper suggests an advanced system which collects device embedded products at the end of their lives to satisfy various products, components and materials requirements. The system identifies favorable design(s) for disassembly or remanufacturing based on three criteria viz., total profit, quality level and the number of disposed items. A method involving Linear Physical Programming (LPP) is used to formulate the problem. An example involving cell phones is used to illustrate the proposed methodology.
Pregnancy in Kidney Disease

Pregnancy rates in women with chronic kidney disease (CKD) are increasing even in those with end-stage kidney disease (ESKD) maintained on renal replacement therapy. Pregnancies in this population can result in a variety of maternal and fetal complications, but outcomes have improved over the last 50 years. The effect of pregnancy on progression of CKD is likely minimal in those with early stages of CKD but can be a significant concern in those with CKD stages 3–5. Hypertension and proteinuria are common maternal complications, and preeclampsia, a challenge to diagnose, has been reported to occur in as many as 19% of cases. In more advanced stages of CKD, fetal complications commonly include preterm delivery, intrauterine growth retardation, and reduced infant survival. These complications have recently been noted to be in decline with recent reports confirming improved fetal outcomes and no significant increases in maternal mortality. Improved management of comorbidities such as hypertension, intensified dialysis in women with ESKD, and close to attention to management of CKD-associated complications such as volume control and nutrition, anemia, and mineral-bone disease factors is an important advance that likely is associated with these improved outcomes. These issues are discussed in detail in this chapter.
Worse outcomes associated with public insurance at sarcoma diagnosis in adolescent and young adults (AYAs).

e18143Background: Studies have shown that having public or no insurance at sarcoma diagnosis is associated with higher stage disease and poor survival. However, previous studies have not differenti...
Abstract 525: In vitro Reverse Remodeling After Mechanical Unloading With Engineered Heart Tissue

LVADs serve as a bridge to transplantation for many dilated cardiomyopathy (DCM) patients with advanced heart failure. In rare cases, mechanical unloading can lead to reverse myocardial remodeling ...
An embodied design for grounding the mathematics of slope in middle school students' perceptions of steepness

The goal of this design-based research study was the creation and evaluation of a mini-unit intended to foster perceptually grounded understandings of the concept of slope in middle-school students...
In-Plane and Interfacial Thermal Conduction of Two-Dimensional Transition-Metal Dichalcogenides

We elucidate the dependence of the in-plane and interfacial thermal conduction of two-dimensional (2D) transition-metal dichalcogenide (TMDC) materials (including ${\mathrm{Mo}\mathrm{S}}_{2}$, ${\mathrm{WS}}_{2}$, and ${\mathrm{W}\mathrm{Se}}_{2}$) on the materials' physical features, such as size, layer number, composition, and substrates. The in-plane thermal conductivity k is measured at suspended 2D TMDC materials and the interfacial thermal conductance g is measured at materials supported on substrates, both through Raman thermometry techniques. The thermal conductivity k increases with the radius R of the suspended area following a logarithmic scaling as k\ensuremath{\sim}log(R). k also shows a substantial decrease from monolayer to bilayer, but only changes slightly with a further increase in the layer number. In contrast, the interfacial thermal conductance g has a negligible dependence on the layer number, but g increases with the strength of the interaction between 2D TMDC materials and the substrate, substantially varying among different substrates. The result is consistent with theoretical predictions and clarifies much inconsistence in the literature. This work provides useful guidance for thermal management in 2D TMDC materials and devices.
A 51-Year-Old Man With Hoarseness of Voice.

Case Presentation A 51-year-old nonsmoking man presented to his general practitioner with a primary complaint of 4 months of progressive hoarseness, and was subsequently referred to an otolaryngologist. He had no relevant medical or surgical history. He did not take any chronic medications or supplements. He was born in the Dominican Republic and moved to New York City when he was 36 years old. He worked in construction. In his spare time, he would return to his home country. The patient was a lifelong nonsmoker and reported no alcohol consumption. He denied shortness of breath, cough, sputum expectoration, fevers, chills, and night sweats.
A patient-centred, comprehensive model for the care for heart failure: the 360° heart failure centre.

Heart failure (HF) is a chronic heterogeneous clinical syndrome that is unified by the presence of clinical signs and symptoms of congestion and by the difficulty of its diagnosis and management. Its prevalence, of 6.5 million people in the USA,1 is rising due to an increasing incidence and to advances in medical, interventional and device therapies which extend the longevity of the affected patients. Despite these advances, HF is characterised by intermittent and recurrent exacerbations, which are associated with high morbidity, mortality and costs. The estimated costs of HF care are 40 billion dollars annually in the USA, from which >10 billion are due to hospital admissions after presentation to an emergency department (ED).2 Currently, the care paradigm for patients with HF is dichotomous, divided between the care of patients with chronic compensated HF in the outpatient setting and acute decompensated heart failure (ADHF) in an inpatient setting. Patients with compensated HF are managed longitudinally in outpatient clinics, including HF cardiology clinic, general cardiology clinic and primary care clinics. Traditionally, each of these clinics exist as independent ‘silos’ with limited direct communication between them. Furthermore, they are designed, staffed and supplied to provide traditional outpatient care, with limited ability to intervene in a rapid or invasive way. This is clearly focused on the evaluation and management of compensated patients. Perhaps it is not surprising that ADHF accounts for over 1 million annual ED presentations in the USA.2 When a patient with ADHF presents to any of the above-mentioned clinical offices, there is a limited infrastructure and capabilities to address their acute needs. For a mild decompensation, oral diuretics may be adjusted with a plan for follow-up laboratories and phone calls. For a more severe decompensation, a patient may be directly admitted to the hospital or referred to the nearest ED. More …
Tread Patterns and the Effect on Basketball Player Slippage

The focus of this study was to investigate the effects that different basketball shoe outsole tread patterns have on the amount of slip and therefore the performance of the individual while undergo...
The effect of PEGylation on the efficacy and uptake of an immunostimulatory nanoparticle in the tumor immune microenvironment.

The efficacy of immunotherapies is often limited by the immunosuppressive tumor microenvironment, which is populated with dysfunctional innate immune cells. To reprogram the tumor-resident innate immune cells, we developed immunostimulatory silica mesoporous nanoparticles (immuno-MSN). The cargo of immuno-MSN is a Stimulator of Interferon Gene (STING) agonist, which activates innate immune cells leading to production of interferon (IFN) β. By proficiently trafficking its cargo into immune cells, the immuno-MSN induced a 9-fold increase of IFN-β secretion compared to free agonist. While an external PEG shield has historically been used to protect nanoparticles from immune recognition, a PEGylated immunostimulatory nanoparticle needs to strike a balance between immune evasion to avoid off-site accumulation and uptake by target immune cells in tumors. Using the 4T1 mouse model of metastatic breast cancer and flow cytometry, it was determined that the degree of PEGylation significantly influenced the uptake of ‘empty’ MSNs by tumor-resident innate immune cells. This was not the case for the agonist-loaded immuno-MSN variants. It should be noted the surface charge of the ‘empty’ MSNs was positive rather than neutral for the agonist-loaded immuno-MSNs. However, even though the cellular uptake was similar at 24 h after injection for the three immuno-MSN variants, we observed a significant beneficial effect on the activation and expansion of APCs especially in lung metastasis using the lightly PEGylated immuno-MSN variant.
Prioritising the Key Factors Influencing the Adoption of Mobile Wallets: An Indian Perspective in Covid-19 Era

The purpose of this paper is to identify and prioritise mobile wallet (m-wallet) key adoption factors (KAFs). 9 KAFs are proposed by authors on the basis of systematic literature review. Authors have proposed one novel factor influencing adoption called ‘contactless transactions’ due to pandemic and new normal post-Covid-19. This has resulted in a total of 10 KAFs. Fuzzy TOPSIS approach is proposed to rank these key adoption factors (KAFs). Sensitivity analysis has also been conducted to check the robustness of the study. Examining the literature indicates that this study is among the first attempts to prioritise key adoption factors (KAFs) using fuzzy TOPSIS. The results show that perceived security, trust, performance expectancy, perceived ease of use and contactless transactions are among the top 5 adoption factors. The findings of this research will be beneficial for both academicians and practitioners. The key adoption factors (KAFs) proposed in the paper will help practitioners develop strategies for building a wider acceptance of m-wallet among customers. Moreover, the fuzzy TOPSIS technique discussed in this paper will apprise managers about critical factors to be focused upon. This study will provide an integrated framework for academicians to carry out further research in the field of mobile wallets.
Conditional Recovery Estimation Through Probability Kriging — Theory and Practice

The probability kriging technique is an improvement on the distribution free indicator kriging technique for obtaining conditional recoverable reserves. Probability kriging is similar to indicator kriging in that both techniques utilize indicator data and no assumption concerning the shape of the conditional distribution is made. Indicator kriging however does not utilize some easily obtainable information which causes, in certain cases, the indicator kriging estimator to be smoothed, conditionally biased, and in general a poor local estimator. The cases where indicator kriging performs poorly will be identified and it will be shown that by including additional information, through the probability kriging estimator, that the quality of the estimator will be improved. The probability kriging technique is then tested on a gold deposit and the results are presented.
Eye finding via face detection for a foveated, active vision system

Eye finding is the first step toward building a machine that can recognize social cues, like eye contact and gaze direction, in a natural context. In this paper, we present a real-time implementation of an eye finding algorithm for a foveated active vision system. The system uses a motion-based prefilter to identify potential face locations. These locations are analyzed for faces with a template-based algorithm developed by Sinha (1996). Detected faces are tracked in real time, and the active vision system saccades to the face using a learned sensorimotor mapping. Once gaze has been centered on the face, a high-resolution image of the eye can be captured from the foveal camera using a self-calibrated peripheral-ta-foveal mapping.We also present a performance analysis of Sinha's ratio template algorithm on a standard set of static face images. Although this algorithm performs relatively poorly on static images, this result is a poor indicator of real-time performance of the behaving system. We find that our system finds eyes in 94% of a set of behavioral trials. We suggest that alternate means of evaluating behavioral systems are necessary.
Theorizing Religious Abuse within the Context of Intimate Partner Violence: The African American Community

This work conceptualizes the perpetration of religious abuse within the context of intimate partner violence (ipv ). Some scholars have examined the importance of spirituality or religion in the lives of domestic violence survivors, and only a few have explored how abusers use religion to mistreat their partners. This gap in the literature has caused religious abuse itself to be understudied, as a method of control within ipv . The author presents an argument supporting the need to acknowledge religious abuse, details a set of tactics that may be used, and describes the occurrence of this abuse through the description of a theoretical model that focuses on the African American community.