cssi/SciSciGPT-SciSciNet huggingface dataset:
Treatment of a dog with severe baclofen intoxication using hemodialysis and mechanical ventilation

Objective: This case report describes the successful management of a dog with coma and respiratory depression due to severe baclofen intoxication. Case summary: A Doberman Pinscher mixed breed dog ingested 500 mg (20 mg/kg) of baclofen. Signs of severe intoxication included coma and profound respiratory muscle weakness. The dog was supported with positive pressure ventilation and treated with one session of hemodialysis. Weaning from the ventilator was achieved within 4 hours of hemodialysis, and recovery from coma occurred over the following 12–36 hours. The dog regained full neurologic function and was normal at discharge following 3 days of hospitalization. New or unique information provide: Severe central nervous system depression and respiratory depression due to baclofen intoxication can be life threatening. In addition to other supportive care, hemodialysis may hasten recovery and ventilatory support may be essential to achieve a positive outcome. With successful treatment, toxicity can be decreased and the associated life-threatening central nervous system and ventilatory depression can resolve. Prognosis for return of normal function is excellent.
A comparison of chelator‐facilitated metal uptake by a halophyte and a glycophyte

Phytoextraction is the use of plants to remove contaminants, in particular metals, from soil via root uptake and translocation to the shoots. Efficient phytoextraction requires high-biomass plants with efficient translocating properties. Halophytes characteristically accumulate large quantities of salts in above ground tissue material and can have high biomass production. It has been speculated that salt-tolerant plants may also be heavy metal tolerant and, further, may be able to accumulate metals. This study compared growth and metal uptake by a halophyte, Atriplex nummularia, and a common glycophyte, Zea mays, in a mine-tailing contaminated soil:mulch mixture. Two chelators, ethylenediaminetetraacetic acid (EDTA) and rhamnolipid, were used to facilitate plant metal uptake. Despite a lower growth rate (2% growth/d) in the contaminated soil, the halophyte accumulated roughly the same amount of metals as the glycophyte on a mass basis (30-40 mg/kg dry wt). Neither plant, however, hyperaccumulated any of the metals tested. When treated with EDTA, specific differences in patterns of metal uptake between the two plants emerged. The halophyte accumulated significantly more Cu (2x) and Pb (1x) in the shoots than the glycophyte, but root metal concentrations were generally higher for the glycophyte, indicating that the halophyte translocated more metal from the root to the shoot than the glycophyte. For example, Zn shoot-to-root ratios ranged from 1.4 to 2.1 for Atriplex and from 0.5 to 0.6 for Z. mays. The biodegradable chelator rhamnolipid was not effective at enhancing shoot metal concentrations, even though radiolabeled chelator was found in the shoot material of both plants. Our results suggest that halophytes, despite their slower growth rates, may have greater potential to selectively phytoextract metals from contaminated soils than glycophytes.
Ultrastructural observations of the migration and early development of trigeminal motoneurons in chick embryos.

The migration of immature chick trigeminal (V) motoneurons from a miclline medial column to a lateral nucleus was studied between days 3 and 7 of incubation. The somatic translocation of these cells is preceded by the lateral outgrowth of their axons. At days 3–4 the axons grow within extracellular spaces dorsal to pial end feet at the external limiting membrane. At later ages the axons grow deeper within the intermediate zone. Upon reaching the medial border of the V sensory tract the axons turn ventrally, exit from the neural tube, and grow toward the mandibular arch. The medial column somas rotate from their original radial orientation to lie parallel to the pial surface. They migrate laterally in close association with fiber bundles composed of axonal and trailing processes of medial column and other migrating V motoneurons. Several punctate contacts are made between the migrating cells and the axon bundles; these contacts may stabilize the somas while the growing tips of their axons elongate. During migration the cytoplasm of the V motoneuron matures, acquiring rough endoplasmic retic-ulum, lysosomes, and multivesicular bodies. Immature synapses contact premigratory, migratory, and postmigratory cells on day 4. Their maturation on day 5 coincides with the onset of active jaw movements. Some V motoneurons secondarily migrate dorsally from the lateral nucleus while their trailing axons are in the head mesenchyme. Few punctate contacts are observed between these cells and their substrate, the longitudinal fibers of the lateral longitudinal fasciculus. Postmigratory dorsal V motoneurons are organelle poor and have few synaptic contacts by day 7. This undifferentiated state may reflect a later onset of the spontaneous movement of their target, the levator palpebrae muscle.
Sambia Sexual Culture: Essays from the Field

Sambia Sexual Culture: Essays from the Field. Gilbert Herdt. Chicago: University of Chicago, 1999. 327 pp.
Hybrid Organic-Inorganic Inhibitors of a PDZ Interaction that Regulates the Endocytic Fate of CFTR

Together strong: Cooperative binding of organic (see picture, red) and inorganic fragments provides a strategy for the potent inhibition of protein-protein interactions. By targeting specific Lewis basic side chains in peripheral regions of the binding site for coordination to a rhodium(II) center, the affinity of otherwise weak ligands is improved.
An Efficient AC–DC Step-Up Converter for Low-Voltage Energy Harvesting

The conventional two-stage power converters with bridge rectifiers are inefficient and may not be practical for the low-voltage microgenerators. This paper presents an efficient ac-to-dc power converter that avoids the bridge rectification and directly converts the low AC input voltage to the required high dc output voltage at a higher efficiency. The proposed converter consists of a boost converter in parallel with a buck-boost converter, which are operated in the positive half cycle and negative half cycle, respectively. Detailed analysis of the converter is carried out to obtain relations between the power, circuit parameters, and duty cycle of the converter. Based on the analysis, control schemes are proposed to operate the converter. Design guidelines are presented for selecting the converter component and control parameters. A self-starting circuit is proposed for independent operation of the converter. Detailed loss calculation of the converter is carried out. Simulation and experimental results are presented to validate the proposed converter topology and control schemes.
Prevalence of major infections and adverse outcomes among hospitalized. ST-elevation myocardial infarction patients in Florida, 2006

ST-elevation myocardial infarction (STEMI) patients have risk factors and co-morbidities and require procedures predisposing to healthcare acquired infections (HAIs). As few data exist on the extent and consequences of infections among these patients, the prevalence, predictors, and potential complications of major infections among hospitalized STEMI patients at all Florida acute care hospitals during 2006 were analyzed. Sociodemographic characteristics, risk factors, co-morbidities, procedures, complications, and mortality were analyzed from hospital discharge data for 11, 879 STEMI patients age ≥18 years. We used multivariable logistic regression modeling to examine and adjust for multiple potential predictors of any infection, bloodstream infection (BSI), pneumonia, surgical site infection (SSI), and urinary tract infection (UTI). There were 2, 562 infections among 16.6% of STEMI patients; 6.2% of patients had ≥2 infections. The most prevalent HAIs were UTIs (6.0%), pneumonia (4.6%), SSIs (4.1%), and BSIs (2.6%). Women were at 29% greater risk, Blacks had 23% greater risk, and HAI risk increased 11% with each 5 year increase in age. PCI was the only protective major procedure (OR 0.81, 95% CI, 0.69-0.95, p < .05). HAI lengthened hospital stays. STEMI patients with a BSI were almost 5 times more likely (31.3% vs. 6.5%, p < .0001), and those with pneumonia were 3 times more likely (19.6% vs. 6.5%, p < .0001) to die before discharge. The protective effect of PCI on risk of infection is likely mediated by its many benefits, including reduced length of hospitalizations.
Spatiotemporal Variation of Juvenile Common Carp Foraging Patterns as Inferred from Stable Isotope Analysis

Abstract Ontogenetic diet shifts from zooplankton to macroinvertebrates represent an important transition for many fishes during early life stages. However, some fishes have plastic feeding habits that allow them to take advantage of abundant prey resources or display diet specialization instead of undergoing distinct diet shifts. In this study, we evaluated ontogenetic changes in energy sources (based on the carbon isotope signature, δ13C) and trophic position (based on the nitrogen isotope signature, δ15N) for age-0 Common Carp Cyprinus carpio from eight natural lakes in eastern South Dakota. In general, Common Carp trophic position decreased and energy sources shifted from pelagic to littoral prey resources from July to August. As anticipated, substantial inter- and intrapopulation variation existed in Common Carp isotope signatures. Common Carp trophic position increased with increasing fish TL in three lakes but decreased with fish TL in two systems. Intrapopulation variation in trophic position was ...
Knowledge-based real-time machines interaction

The authors describe the need for robotic machine interaction and discuss their recent and ongoing research projects in two main areas: multirobot systems, and interactive robotic devices (IRD) for handicapped persons. In both areas they have found the knowledge-based interaction increases significantly the flexibility, reliability, and responsiveness of the system. A number of decision-support modeling approaches for intermodule communication, distributed control, and distributed decision-making for concurrent and cooperative machine activities are described. They are currently being investigated for their usefulness in answering the research problems. >
Parent-Adolescent Communication About Sex: Retrospective Reports by Latino College Students

Latina female (n = 97) and Lati- no male (n = 69) college students (M age =21.4 years) completed self-report surveys regarding family of origin ex periences, including sexual communication with parents while growing up. Latino parents of this comparatively highly edu- cated sample tended to use direct rather than in- direct strategies for com municating about sexu- ality with their children. Young women report- ed higher levels of sexual communication with mothers while growing up than did young men, and respondents reported less communication with fathers than mothers. Among young wom- en, sexual communication with mother was pos- itively associated with non-Mexican origin and negatively associated with having older broth ers living at home. In contrast, maternal education was positively associated with mother-son com- munication about sex. Paternal education and the absence of older brothers positively predict- ed com munication with both sons and daughters. The analyses provide novel information regard- ing sex ual communication in Latino families and suggest directions for future research.
Highly selective CO2/CH4 gas uptake by a halogen-decorated borazine-linked polymer

A new borazine-linked polymer featuring chlorine-decorated cavities, BLP-10(Cl), has been prepared by the thermal decomposition of benzidine–boron trichloride in toluene under refluxing conditions. BLP-10(Cl) exhibits a moderate Langmuir surface area (1308 m2 g−1) and one of the highest CO2/CH4 selectivities (28.3) by porous materials at 1.0 bar and 273 K. Computational studies revealed that H2, CO2, and CH4 interact more favorably with the borazine unit with isosteric heats of adsorption of 7.46, 28.3, and 20.2 kJ mol−1, respectively. These values are in good agreement with experimental data collected by using the virial method. Results from this study suggest that including highly polarizable and halogenated building units into the framework of porous architectures can significantly enhance their performance in gas separation applications.
Aberrant Growth and Pattern Formation in Peromyscus Hybrid Placental Development

Crosses between the North American deer mouse species Peromyscus maniculatus (BW) and P. polionotus (PO) produce dramatic asymmetric developmental effects. BW females mated to PO males (female bw × male po) produce viable growth-retarded offspring. In contrast, PO females mated to BW males (female PO × male BW) produce overgrown but dysmorphic conceptuses. Most female PO × male BW offspring are dead by midgestation; those surviving to later time points display numerous defects reminiscent of several diseases. The hybrid effects are particularly pronounced in the placenta. Here we examine placental morphological defects via histology and in situ hybridization as well as the relationship between growth and mortality in the female PO × male BW cross. These assays indicate altered hybrid fetal:placental ratios by the equivalent of mouse (Mus) Embryonic Day (E) 13 and disorganization and labyrinth defects in female PO × male BW placentas and confirm earlier suggestions of a severely reduced junctional zone in the female bw × male po hybrids. Further, we show that both cellular proliferation and death are abnormal in the hybrids through BrdU incorporation and TUNEL assays, respectively. Together the data indicate that the origin of the effects is prior to the equivalent of Mus E10. Finally, as the majority of these assays had not previously been performed on Peromyscus, these studies provide comparative data on wild-type placentation.
Reduced models of atmospheric low-frequency variability: Parameter estimation and comparative performance

Abstract Low-frequency variability (LFV) of the atmosphere refers to its behavior on time scales of 10–100 days, longer than the life cycle of a mid-latitude cyclone but shorter than a season. This behavior is still poorly understood and hard to predict. The present study compares various model reduction strategies that help in deriving simplified models of LFV. Three distinct strategies are applied here to reduce a fairly realistic, high-dimensional, quasi-geostrophic, 3-level (QG3) atmospheric model to lower dimensions: (i) an empirical–dynamical method, which retains only a few components in the projection of the full QG3 model equations onto a specified basis, and finds the linear deterministic and the stochastic corrections empirically as in Selten (1995) [5] ; (ii) a purely dynamics-based technique, employing the stochastic mode reduction strategy of Majda et al. (2001) [62] ; and (iii) a purely empirical, multi-level regression procedure, which specifies the functional form of the reduced model and finds the model coefficients by multiple polynomial regression as in Kravtsov et al. (2005) [3] . The empirical–dynamical and dynamical reduced models were further improved by sequential parameter estimation and benchmarked against multi-level regression models; the extended Kalman filter was used for the parameter estimation. Overall, the reduced models perform better when more statistical information is used in the model construction. Thus, the purely empirical stochastic models with quadratic nonlinearity and additive noise reproduce very well the linear properties of the full QG3 model’s LFV, i.e. its autocorrelations and spectra, as well as the nonlinear properties, i.e. the persistent flow regimes that induce non-Gaussian features in the model’s probability density function. The empirical–dynamical models capture the basic statistical properties of the full model’s LFV, such as the variance and integral correlation time scales of the leading LFV modes, as well as some of the regime behavior features, but fail to reproduce the detailed structure of autocorrelations and distort the statistics of the regimes. Dynamical models that use data assimilation corrections do capture the linear statistics to a degree comparable with that of empirical–dynamical models, but do much less well on the full QG3 model’s nonlinear dynamics. These results are discussed in terms of their implications for a better understanding and prediction of LFV.
Analysis of different AGV control systems in an integrated IC manufacturing facility, using computer simulation

In an integrated Manufacturing Facility, consisting of various individual manufacturing cells, an automated material handling system (AMHS) - such as an Automated Guided Vehicle System (AGVS) - servicing each of cells plays a major role. In order to understand, and choose, the correct type of AGV system, simulation techniques can be used very effectively. In this paper, two different AGV Control Systems have been analyzed with computer simulation models. These animated graphic models also include details of all the individual process steps from the Wafer Sort operation through the Test processes of an IC Manufacturing Facility at Intel. The simulation model is used to analyze the behavior of the AGVS, as measured by the average AGV utilizations, AGV congestion levels, average AGV response times, as well as process characteristics such as Throughput Time through the line, Work in Process levels and overall product throughput through the line. The model has been used to recommend the proper AGV control logic, as well as the number of vehicles required.
From symptom to cause: localizing errors in counterexample traces

There is significant room for improving users' experiences with model checking tools. An error trace produced by a model checker can be lengthy and is indicative of a symptom of an error. As a result, users can spend considerable time examining an error trace in order to understand the cause of the error. Moreover, even state-of-the-art model checkers provide an experience akin to that provided by parsers before syntactic error recovery was invented: they report a single error trace per run. The user has to fix the error and run the model checker again to find more error traces.We present an algorithm that exploits the existence of correct traces in order to localize the error cause in an error trace, report a single error trace per error cause, and generate multiple error traces having independent causes. We have implemented this algorithm in the context of slam, a software model checker that automatically verifies temporal safety properties of C programs, and report on our experience using it to find and localize errors in device drivers. The algorithm typically narrows the location of a cause down to a few lines, even in traces consisting of hundreds of statements.
Age determination of recent cave deposits using excess 210Pb ‐ A new technique

Cave deposits have been widely used as proxy recorders in deciphering palaeoclimate during the last glacial/interglacial maxima (∼ 120 ka) [Harmon et al., 1975; Atkinson et al., 1978; Goede and Harmon, 1983; Ayliffe and Veeh, 1989]. Palaeoclimatic studies of cave deposits for the past 1–1000 yr time scale require a precise dating technique, that until now has been lacking. Due to the multiple sources of carbon in speleothems, 14C dates obtained for recently deposited calcite are highly variable and thus, 14C dating techniques are not suitable to obtain speleothem ages for the past 1–1000 years. Here, we show for the first time that speleothems contain high concentrations of excess 210Pb and that this 210Pb excess can be successfully employed to obtain growth rates of speleothems deposited during the last 100 years. Of two specimens analyzed, a tubular “soda straw” stalactite yielded a longitudinal growth rate of 1.1 mm/yr, while a normal icicle-shaped stalactite had a lateral growth rate of 0.028 mm/yr. The mass growth rates of these two speleothems (149 and 78 mg/yr respectively) are comparable within a factor of two. Studies of fine-scale variations in the isotopic composition of recent speleothems will help to corroborate the validity of palaeoclimate records obtained using longer lived isotopes and extending back into Pleistocene.
Multilevel predictors of adolescent physical activity: a longitudinal analysis

Background: To examine how factors from a social ecologic model predict physical activity (PA) among adolescents using a longitudinal analysis. Methods: Participants in this longitudinal study were adolescents (ages 10-16 at baseline) and one parent enrolled in the Transdisciplinary Research on Energetics and Cancer-Identifying Determinants of Eating and Activity (TRECIDEA) and the Etiology of Childhood Obesity (ECHO). Both studies were designed to assess a socio-ecologic model of adolescent obesity risk. PA was collected using ActiGraph activity monitors at two time points 24 months apart. Other measures included objective height and weight, adolescent and parent questionnaires on multilevel psychological, behavioral and social determinants of PA, and a home PA equipment inventory. Analysis was conducted using SAS, including descriptive characteristics, bivariate and stepped multivariate mixed models, using baseline adjustment. Models were stratified by gender. Results: There were 578 adolescents with complete data. Results suggest few statistically significant longitudinal associations with physical activity measured as minutes of MVPA or total counts from accelerometers. For boys, greater self-efficacy (B = 0.75, p = 0.01) and baseline MVPA (B = 0.55, p < 0.01) remained significantly associated with MVPA at follow-up. A similar pattern was observed for total counts. For girls, baseline MVPA (B = 0.58, p = 0.01) and barriers (B = -0.32, p = 0.05) significantly predicted MVPA at follow-up in the full model. The full multilevel model explained 30% of the variance in PA among boys and 24% among girls. Conclusions: PA change in adolescents is a complex issue that is not easily understood. Our findings suggest early PA habits are the most important predictor of PA levels in adolescence. Intervention may be necessary prior to middle school to maintain PA through adolescence.
Digital Age | Managing Opacity: Information Visibility and the Paradox of Transparency in the Digital Age

Organizational transparency is in vogue. When technologies make it possible for information about actors’ behaviors, communications, decisions, and opinions to be visible to interested parties, those actors and the organizations in which they work will presumably be forced to behave more responsibly because they can be held accountable for their actions. The assumption traditionally held by scholars who theorize the relationship between visibility and transparency is that more visibility results in higher levels of transparency. In this paper, we question this assumption. We begin by distinguishing between transparency and visibility and offer a conceptualization of visibility as the combination of three attributes: availability of information, approval to disseminate information, and accessibility of information to third parties. Although transparency is generally believed to be achieved at high levels of each of these attributes, we demonstrate how highly visible information can actually increase opacity and how each attribute of visibility independently and/or co-jointly contributes to the degree to, and manner in which, the relationship between visibility and transparency is managed. Our discussion surfaces a phenomenon we call the “transparency paradox” in which high levels of visibility decrease transparency and produce opacity. The theorization of this transparency paradox and the mechanisms through which it operates have important implications for theory and practice surrounding the role of technologies in organizational action in the digital age.
O2 activation at the Au/MgO(001) interface boundary facilitates CO oxidation

Density functional theory calculations reveal that the work function of Au supported on MgO(001) is substantially reduced because of an interfacial dipole moment formed at the Au/MgO interface. Consequently, the Au/MgO interface plays an active role in the activation of O2 molecules by promoting charge transfer to the O2 2π* orbital. The presence of F-centers in the MgO substrate can further promote the charge transfer and bonding of O2 at the interface boundary. However, O2 dissociation is kinetically hindered. The system is then able to catalyze CO oxidation at low temperature as adsorbed CO and O2 readily react to form CO2 with a low energy barrier.
On the fundamental groups of space-times in general relativity

It is shown that there are upper bounds on the first and second betti numbers of compact space-times or space-times with Cauchy surfaces whose fundamental groups are abelian. Homological classifications of compact space-times and space-times with compact Cauchy surfaces are given.
The Role of TQM in Advertising: A Conceptualization and a Framework for Application

This paper explores the link: between Total Quality Management (TQM) and advertising from both a conceptual and an applied perspective. A conceptual framework is provided which outlines how TQM fits within the marketing and advertising function. Using this conceptual framework, the implementation of TQM in advertising is reviewed and case study examples are presented to illustrate different applications. Also, the nature of the client and agency relationship is examined using data collected from an agency and one of their clients. Finally, the question of whether it is advisable to make quality claims in advertising is addressed. The paper concludes by examining some of the challenges inherent in successfully applying TQM in advertising.
Perspectives from the Field: Opinion: The NEPA and Major Water Resource Planning for the Future. What's the problem? Analysis Paralysis

Federal water resources development planning and the associated environmental assessment processes have been very complex and expensive. Federal water resource agencies are reassessing approaches t...
Rosacea: an update.

Rosacea is a common inflammatory skin disease affecting the central face of adults. Its etiology is unknown. Early diagnosis and appropriate treatment, usually with topical or systemic antibiotics or both, minimizes symptoms and helps to prevent complications.
The toxic effects of three different dosages of pentobarbital sodium on the Long-Evans rat

Male Long-Evans rats were statistically superior to females in recovering from intraperitoneal injections of pentobarbital sodium. The data also provide support for a stock difference previously reported.
Distribution and Age Composition of Mosquito Species (Diptera: Culicidae) Inhabiting Commercial Rice Fields in Southeast Arkansas

Five species of immature mosquitoes were identified from semiweekly and weekly sampling of four commercial rice fields in southeastern Arkansas. Psorophora columbiae (Dyar and Knab) and Anopheles quadrimaculatus Say were most abundant. Large numbers of P. columbiae were encountered immediately following flood applications, with larvae from the upper halves of each field being older than those from the lower halves due to the time required for irrigation water to inundate the entire field. Significantly more P. columbiae larvae were found in ditch than pan samples (69 and 31%, respectively). Anopheles quadrimaculatus were collected on every sample date. Moderate numbers peaked 10 July and thereafter were very low. Young larvae predominated in samples until 10 July, when slightly more than half of the immature A. quadrimaculatus collected were third and fourth-stage larvae. Larvae sampled were evenly distributed between ditch and pan areas (49 and 51%, respectively). Culex erraticus (Dyar and Knab) larvae were also collected on every sample date at very low levels. A significantly larger proportion were taken from levee ditches than pan areas (62 and 38%, respectively). Aedes vexans Meigen and Uranotaenia sapphirina (Osten-Sacken) were collected occasionally.
Operative Treatment for Hallux Valgus in Cerebral Palsy

Ten feet of seven patients with cerebral palsy were surgically corrected for hallux valgus deformity. All patients were ambulatory, and all had symptomatic bunion and hallux valgus deformities before surgery. The mean age of the patients at the time of surgery was 13.8 years (range; 10-18 years). The mean age of the patients at the time of follow-up was 20.7 years (range; 13-25 years). The mean hallux valgus angle was 28° preoperatively, and 1° postoperatively. The operative procedure consisted of distal first metatarsal osteotomy, adductor hallucis muscle transfer, and soft tissue release. Postoperatively, all patients had no pain, and hallux valgus deformities were adequately corrected in six feet, however, varus deformities of hallux were seen in four feet. On two of the four feet, tenotomy and transfer of abductor hallucis muscle were performed and they now have good results with no pain. Apparently spasticity of the abductor hallucis muscle causes varus deformity of the hallux after adductor muscle transfer.
Time and the Temporal Imagination

Time has been one of the most challenging and elusive concepts in human thought, and it is only now beginning to receive the attention it deserves in organizational scholarship. To this growing sch...
Hierarchical Bayesian approaches for detecting inconsistency in network meta‐analysis

Network meta-analysis (NMA), also known as multiple treatment comparisons, is commonly used to incorporate direct and indirect evidence comparing treatments. With recent advances in methods and software, Bayesian approaches to NMA have become quite popular and allow models of previously unanticipated complexity. However, when direct and indirect evidence differ in an NMA, the model is said to suffer from inconsistency. Current inconsistency detection in NMA is usually based on contrast-based (CB) models; however, this approach has certain limitations. In this work, we propose an arm-based random effects model, where we detect discrepancy of direct and indirect evidence for comparing two treatments using the fixed effects in the model while flagging extreme trials using the random effects. We define discrepancy factors to characterize evidence of inconsistency for particular treatment comparisons, which is novel in NMA research. Our approaches permit users to address issues previously tackled via CB models. We compare sources of inconsistency identified by our approach and existing loop-based CB methods using real and simulated datasets and demonstrate that our methods can offer powerful inconsistency detection. Copyright © 2016 John Wiley & Sons, Ltd.
Teaching reform and practice of vocational pharmacy analytical chemistry task-driven

In recent years,the phenomenon that students in vocational colleges are not interested in foundation cours es is widespread.Department of Pharmacy of Cangzhou Medical College,according to the characteristics of vocational students,introduce the "task-driven teaching" method into the teaching of basic courses of analytical chemistry.By using tasks to lead content teaching,integrating "teach,learn,do" and building "analytical chemistry task-driven teaching" mode,students' interests in learning are improve,and expected results are achieved.
Design and Simulation of Multiple Igniting System for Pasty Propellant Rocket

Aiming at the limited problem of multiple ignition time interval for pasty propellant rocket,plasma ignition plan was proposed.Based on working process of plasma multiple ignitions,multiple igniting system was designed accordingly and each element was analyzed.On the base of electronic performance of plasma arc,the design of fuzzy controller was introduced in detail,and status recognition,control and detection of the whole ignition process was realized.Simulation of Matlab and semi-physical experimental simulation were performed.Results show the system fit the demand of pasty propellant rocket motor multiple igniting,control performance well,and the design was attained.
Coronary Stent Fracture: A New Form of Patient-Prosthesis Mismatch?

Perfection is not attainable, but if we chase perfection we can catch excellence.—Vince Lombardi [(1)][1] Improvements in technology and technique have been associated with continuous, steady declines in post-percutaneous coronary intervention (PCI) adverse events, including clinically
Apical microsurgery for failed endodontics.

Abstract The operating microscope allows the surgeon unparalleled visualization of the root end structures for periapical surgery. The ultrasonic root end preparation tips enable debridement of the resected root end 2 to 4 mm in the long axis of the root. These advances have allowed periapical surgery to be performed at a new level of excellence with, we believe, more predictable healing.
Mindfulness and Mentoring Satisfaction of College Women Mentoring Youth: Implications for Training

College students who mentor at-risk youth face a variety of challenges and unexpected dilemmas. Mindful awareness practices (MAPs) offer a promising strategy for stress reduction and enhanced relationship satisfaction for college students, counseling students, parents, and teachers; yet, the potential benefits for college student mentors remain largely unexamined. This quasi-experimental study analyzed survey data from college student mentors who received a MAP-based intervention (n = 59), and a comparison group comprised mentors who received the same mentor training and group mentoring curriculum, but without the added mindfulness component to examine the following research questions: (a) is the addition of a mindfulness component to college student mentor training associated with mentors’ mentoring satisfaction; (b) does this help them enhance their ability to be empathic in challenging situations; and (c) does this help them shift their inclination for autonomous decision-making and prescriptive mentoring toward a more collaborative, youth-centered approach. Relative to the comparison group, mentors who participated in mindfulness training reported significantly higher mentor satisfaction, greater increases in empathy, and greater decreases in autonomy. Results provide youth-focused programs with new knowledge regarding additional avenues for supporting college students working with youth.
Effects of climate scenarios on the growth and physiology of the Amazonian fish tambaqui ( Colossoma macropomum ) (Characiformes: Serrasalmidae)

This study evaluated the effects of three climate scenarios predicted by the Intergovernmental Panel on Climate Change for 2100, on the growth and physiology of the tambaqui (Colossoma macropomum). Juveniles of tambaqui were reared in four rooms (current conditions, and the climate scenarios B1, A1B and A2) for 150 days. Twelve fish were regularly collected for blood analyses and to have their weight and length measured. The amount of food consumed over the experimental period was recorded. Feed intake, weight gain and food conversion showed an increase in all climate scenarios (P < 0.05). Although these results were expected, the increases in weight gain in the more dramatic environmental situations were due to increases in feed intake. Increases in haematocrit, glucose, cortisol and triglycerides within the first 30 days of the experiment were observed. The present results indicate that climate changes can affect not only its feed intake, but also the growth of the tambaqui and that this fish species can recover blood parameters, suggesting an artificial acclimatization to the analysed environmental conditions after 30 days. Taken to nature, these characteristics of the tambaqui could cause ecological imbalances in the food web, in its frequency of occurrence and in its dominance.
Shared Decision Making With Vulnerable Populations in the Emergency Department

The emergency department occupies a unique position within the health care system, serving as a safety net for vulnerable patients, regardless of their race, ethnicity, religion, country of origin, sexual orientation, socioeconomic status or medical diagnosis. Shared decision making (SDM) presents special challenges when used with vulnerable population groups. The differing circumstances, needs and perspectives of vulnerable groups invoke issues of provider bias, disrespect, judgmental attitudes and lack of cultural competence; as well as patient mistrust, and the consequences of their social and economic disenfranchisement. A research agenda that includes community-engaged approaches, mixed methods studies and cost effectiveness analyses is proposed to address the following questions: 1) What are the best processes/formats for SDM among racial, ethnic, cultural, religious, linguistic, social, or otherwise vulnerable groups who experience disadvantage in the health care system? 2) What organizational or systemic changes are needed to support SDM in the ED whenever appropriate? 3) What competencies are needed to enable emergency providers to consider patients’ situation/context in an unbiased way? 4) How do we teach these competencies to students and residents? 5) How do we cultivate these competencies in practicing emergency physicians, nurses and other clinical providers who lack them? The authors also identify the importance of using accurate, group-specific data to inform risk estimates for SDM decision aids for vulnerable populations and the need for increased emergency department-based care coordination and transitional care management capabilities to create additional care options that align with the needs and preferences of vulnerable populations. This article is protected by copyright. All rights reserved.
Proteomic Analysis of Elevated Intraocular Pressure with Retinal Detachment.

Abstract Purpose To report a case of elevated intraocular pressure with retinal detachment. Observations Liquid chromatography and tandem mass spectrometry was performed on the patient aqueous biopsy. Protein levels were analyzed with 1-way analysis of variance (ANOVA) and unbiased clustering. High levels of rod outer segment proteins were not detected, suggesting that this was not a case of Schwartz-Matsuo syndrome. Instead, elevated levels of Hepcidin (HEPC) and Cystatin C (CYTC; candidate biomarkers for primary open angle glaucoma) were detected, suggesting a different, unknown etiology. Conclusions and importance Molecular diagnoses can differentiate between clinical diagnoses and point to common biomarkers or disease mechanisms.
Direct, functional relationship between structural and optical properties in titanium-incorporated gallium oxide nanocrystalline thin films

We present an approach to design Ga2O3-based materials with tunable optical properties. In the Ti-doped Ga2O3 model system, where the Ti content (x) was varied up to ∼5 at. %, Ti induced significant effects on the structural and optical properties. Single-phase β-Ga2O3 formation occurs for a lower Ti content (≤1.5 at. %); however, composite-oxide (Ga2O3-TiO2) formation occurs for a higher Ti content. While band gap reduction (Eg ∼ 0.9 eV) coupled with refractive index (n) enhancement occurs, indicating the electronic-structure modification, with Ti incorporation, the changes are dominant only in the Ga2O3-TiO2-composite. A direct, functional Ti(x)-Eg-n relationship was found, which suggests that tailoring the optical quality and performance of Ga-Ti-O is possible by tuning the Ti content and structure.
Pollen Morphology in the Order Centrospermae

AbstractPollen of 190 species from 16 families has been examined by light and scanning electron microscopy. Three basic pollen types were found: 3-colpate, pantoporate, and pantocolpate, all with a spinulose and tubuliferous/punctate ektexine. The palynological data emphasize the close relationship of the betalain families, and support their association with the anthocyanin families. Caryophyllaceae and Molluginaceae. Pollen morphology reinforces the placement of the Cactaceae and Didiereaceae in the order, and would support the inclusion of Dysphania in the Chenopodiaceae. The pollen grains of the Achatocarpaceae, Bataceae, Gyrostemonaceae and Theligonaceae, none of which had the spinulose and tubuliferous/punctate ektexine, had no counterparts in the remaining taxa examined. Thus, the evidence from palynology does not support their inclusion in the Centrospermae and indicates that their placement should be re-examined.
Abstract 4032: Synergistic effects of Bortezomib and JQ1 for human and canine osteosarcoma treatments

Osteosarcoma (OS) is the most common primary malignant bone tumor of both humans and dogs, with the incidence in dogs being nearly 15 times that observed in humans. Despite advances in treatment of other cancers, the clinical outcome of OS remains poor for the past several decades. Therefore, identifying novel and effective treatments for osteosarcoma is an urgent need. Among the small molecular compounds we tested in a drug screening study, we identified a bromodomain inhibitor (JQ1) that targets bromodomains which modify chromatin and block transcription of key factors, and a proteasome inhibitor that induces cell death through various mechanisms (bortezomib) as having good growth inhibition effects on three canine OS cell lines (D17, Abrams, and Gracie) and two human OS cell lines (SAOS2 and U2OS). We then determined the IC 50 values of these two drugs, the concentration capable of inhibiting proliferation by 50%. The IC 50 values of bortezomib and JQ1 are both within achievable plasma concentrations and tolerable levels. JQ1 inhibited OS cell proliferation and survival by inducing G2 cell cycle arrest, while bortezomib induced G1 cell cycle arrest. In addition, these two drugs decreased cell migration ability in wound healing assay as well as invasion ability in a Matrigel assay. Furthermore, in combination studies using both JQ1 and bortezomib, we identified synergistic effects. With these promising results from in vitro studies, we further examined JQ1 as therapeutic agent in an orthotopic tumor xenograft mouse model. Using OS cells stably transfected with a lucerifase vector, we were able to track the tumor progression during the treatment period. Mice treated with JQ1 did not show any signs of adverse effect to the drug, indicating that JQ1 was safe and well tolerated at a daily dosage of 50 mg/kg (IP). While some of the mice in treatment group showed decreasing tumor growth compared to the control group, tumor growth trends in the two groups were not consistent, suggesting that we have to optimize the model and the treatment protocol as well as to evaluate combination treatments with bortezomib and JQ1 in in vivo models. Citation Format: Ya-Ting Yang, Vilma Yuzbasiyan-Gurkan. Synergistic effects of Bortezomib and JQ1 for human and canine osteosarcoma treatments [abstract]. In: Proceedings of the American Association for Cancer Research Annual Meeting 2017; 2017 Apr 1-5; Washington, DC. Philadelphia (PA): AACR; Cancer Res 2017;77(13 Suppl):Abstract nr 4032. doi:10.1158/1538-7445.AM2017-4032
Utilizing normative theories to develop ethical actions for better privacy practices

This study examines the privacy practices of organizations. We argue that successful deployment of privacy practices based on ethical actions will strengthen privacy protection measures to better p...
Management of Cancer Treatment–Related Diarrhea: Issues and Therapeutic Strategies

The cancer treatment-related diarrhea caused by acute graft-versus-host disease (GVHD) and chemotherapeutic agents, particularly fluoropyrimidines and irinotecan, significantly affects patient morbidity and mortality. The mechanisms causing cancer treatment-related diarrhea are not fully understood, but histopathologic evidence points to a multifactorial process that causes an absorptive and secretory imbalance in the small bowel. Cancer treatment-related diarrhea could be life-threatening, yet assessment and treatment are not currently standardized. Several clinicians participated in a closed roundtable meeting to review the mechanisms of chemotherapy-induced diarrhea (CID) and GVHD-induced diarrhea, management issues in cancer treatment-induced diarrhea, and pharmacologic approaches to treatment. The meeting produced a proposal for new treatment guidelines and an algorithm, which include the use of octreotide for the management of CID- and GVHD-induced diarrhea. The development of diarrhea assessment guidelines that expand on the current National Cancer Institute criteria and allow for better patient management was also proposed.
DAO 2 : Overcoming Overall Storage Overflow in Intermittently Connected Sensor Networks

Many emerging sensor network applications operate in challenging environments wherein sensor nodes do not always have connected paths to the base station. Data generated from such intermittently connected sensor networks therefore must be stored inside the network for some unpredictable period of time before uploading opportunities become available. Consequently, sensory data could overflow limited storage capacity available in the entire network, making discarding valuable data inevitable. To overcome such overall storage overflow in intermittently connected sensor networks, we propose and study a new algorithmic problem called data aggregation for overall storage overflow (DA02). Utilizing spatial data correlation that commonly exists among sensory data, DAO2 employs data aggregation techniques to reduce the overflow data size while minimizing the total energy consumption. To solve DAO2, we uncover a new graph theoretic problem called multiple traveling salesman walks (MTSW), and show that with proper graph transformation, the DAO2 is equivalent to the MTSW. We prove that MTSW is NP-hard and design a (2-1.)-approximation q algorithm, where q is the number of nodes to visit (i.e., the number of sensor nodes that aggregate their overflow data). The approximation algorithm is based on a novel routing structure called minimum q-edge forest that accurately captures information needed for energy-efficient data aggregation. We further put forward a heuristic algorithm and empirically show that it constantly outperforms the approximation algorithm by 15% −30% in energy consumption. Finally, we propose a distributed data aggregation algorithm that can achieve the same approximation ratio as the centralized algorithm under some condition, while incurring comparable energy consumption.
Development and evaluation of haptics-based rehabilitation system

In this paper, we discuss the development and testing of a haptics-based stroke rehabilitation system. The system involves a 6-degrees of freedom haptic device and a virtual reality game designed to induce implicit learning in users. We present the preliminary usability/feasibility study of our system as a rehabilitation tool with 15 healthy subjects while using their non-dominant hand. The three-session study demonstrates improvements in all quantitative performance metrics of the learning tasks and the self-perceived workload levels of the subjects. We also studied the differences in performance arising due to three different assistance modes — no assistance, assist-as-needed, and continuous assistance. Comparing the differences in improvements of the performance metrics among the subject groups suggests that fewer sessions of assisted therapy may have the same effects as more sessions of unassisted therapy. We also observed that within the two assisted groups, the assist-as-needed strategy led to greater improvements than the continuously assisted group; which might be due to the lower mental/physical demand associated with the continuously assisted paradigm.