cssi/SciSciGPT-SciSciNet huggingface dataset:
Female copulatory orgasm and male partner’s attractiveness to his partner and other women

Abstract Women’s copulatory orgasm may function to retain sperm from men with “good genes”, one indicator of which is attractiveness, and one benefit of which is pathogen resistance. Women who perceive their partner to be more (vs. less) attractive are more likely to report orgasm at last copulation. Another benefit of male attractiveness to women is that he may sire offspring that will gain the heritable share of this advantage (i.e., “sexy sons”). Research has not addressed the “Sexy Sons” Hypothesis (e.g., as indicated by women’s perception of other women’s assessments of their partner’s attractiveness) in regards to female copulatory orgasm. We secured self-reports from 439 women in a committed, heterosexual relationship and investigated the relationships between women’s orgasm at last copulation and (1) women’s assessments of their partner’s attractiveness and (2) women’s perceptions of other women’s assessments of their partner’s attractiveness. The results indicate that women mated to more (vs. less) attractive men are more likely to report orgasm at last copulation, and this relationship is mediated by women’s perceptions of other women’s assessments of their partner’s attractiveness. We discuss the mediated relationship, note limitations of the research, and suggest future research directions.
The response of the microvascular system to radiation: a review.

The microvasculature is a ubiquitous organ system having a major role in the pathogenesis of radiation damage to normal tissues. Although the kinetics of radiation damage to endothelial cells is similar to other tissues (as reflected by Do and Dq) the late effect is a manifestation of injury, not only to the endothelial cell population, but also to the basement membrane. Tissue damage is progressive. The initial expression of radiation injury is an increased permeability leading to changes in the extracellular milieu. There is an irregular proliferation of endothelial cells leading to capillaries of irregular diameter and shape. Fibrous proliferation increases the histohematic barrier and is ultimately reflected in a loss of parenchymal cells. Replacement fibrosis progresses until a steady state is reached where the surviving parenchymal cells can be sustained by the microvasculature. The clinical significance depends on the role of the organ system involved. For patients who have medical conditions which adversely effect the stability of the vascular system (hypertension, diabetes, etc.), the expressions of radiation injury may be more severe and increase the morbidity associated with these diseases. Angiogenesis in granulation tissue is less radiosensitive than in steady-state parenchymal tissues. Wound healing is not significantly affected bymore » commonly used therapeutic doses of irradiation, 40-50 Gy delivered 4-6 weeks preoperatively or postoperatively early in the development of the granulation tissue, but may be complicated where a significant degree of fibrosis has developed. The vascular responses leading to telangiectasia were discussed. 39 references.« less
Advocacy for booster seat legislation in Florida: a lesson in politics and policy formation

MVCs are a major contributor to child injury and death. Infant restraint seats and child booster seats have been shown to reduce the odds of severe injury or death when used correctly. While all states have mandated the use of these restraint systems, the age at which a child can be legally restrained using an adult seat belt varies from state to state. Efforts to strengthen Florida's weak child restraint laws have failed for more than a decade; in the 2014 legislative session, advocates succeeded in raising the state's age requirement from 3 years to 5 years. While many factors contributed to this year's success, some key elements included efficient communication of supporting data, a strong and broad advocacy network and the leveraging of election year political rivalries. Efforts to further strengthen the law will continue into future legislative sessions.
Acute effects of palatopharyngoplasty on airway collapsibility.

Objective: The lateral pharyngeal walls contribute to obstruction in obstructive sleep apnea. These structures may be unaffected by uvulopalatopharyngoplasty. This was evaluated by retrospective review of upper airway observations after palatopharyngoplasty. Methods And Patients: The retropalatal airway was endoscopically observed intraoperatively after each procedure in 7 patients. The airway was dilated with nasal continuous positive airway pressure. Results: Transpalatal advancement pharyngoplasty increased the area 120% (P = 0.001), and closing pressure decreased 9.2 cm H2 O (P < 0.01). The maximal anteroposterior length (MAX-AP) and maximal lateral radius increased 90% (P = 0.01) and 60% (P < 0.001), respectively. MAX-AP changed in 2, both increased in 4, and maximal lateral radius increased in 1 patient. The closing pressure change correlated with airway size (r 2 = 0.44, P < 0.05); airway shape was associated with change in MAX-AP (r 2 = 0.51, P < 0.07). Conclusions: Both the anteroposterior and lateral wall dimensions are altered by palatopharyngoplasty techniques, which increase retropalatal airway size. This is not limited to facial advancement surgery. (Otolaryngol Head Neck Surg 1999;121:82-6.)
The Connective Tissue Fiber-Water Interface: Physiological and Pathological Implications

Water has an important role in the maintenance of the structure and strength of collagen fibers. Lathyrism and certain corticoid hormones alter the degree of hydration of the fibers and consequently affect their strength.
Negative Immune Regulator Tim-3 Is Overexpressed on T Cells in Hepatitis C Virus Infection and Its Blockade Rescues Dysfunctional CD4+ and CD8+ T Cells

A number of emerging molecules and pathways have been implicated in mediating the T-cell exhaustion characteristic of chronic viral infection. Not all dysfunctional T cells express PD-1, nor are they all rescued by blockade of the PD-1/PD-1 ligand pathway. In this study, we characterize the expression of T-cell immunoglobulin and mucin domain-containing protein 3 (Tim-3) in chronic hepatitis C infection. For the first time, we found that Tim-3 expression is increased on CD4(+) and CD8(+) T cells in chronic hepatitis C virus (HCV) infection. The proportion of dually PD-1/Tim-3-expressing cells is greatest in liver-resident T cells, significantly more so in HCV-specific than in cytomegalovirus-specific cytotoxic T lymphocytes. Tim-3 expression correlates with a dysfunctional and senescent phenotype (CD127(low) CD57(high)), a central rather than effector memory profile (CD45RA(negative) CCR7(high)), and reduced Th1/Tc1 cytokine production. We also demonstrate the ability to enhance T-cell proliferation and gamma interferon production in response to HCV-specific antigens by blocking the Tim-3-Tim-3 ligand interaction. These findings have implications for the development of novel immunotherapeutic approaches to this common viral infection.
Strong coupling, unification, and recent data.

The prediction of strong coupling assuming (supersymmetric) coupling constant unification is reexamined. We find, using the new electroweak data, {alpha}{sub {ital s}}({ital M}{sub {ital Z}}){approx}0.129{plus_minus}0.010. The implications of the large {alpha}{sub {ital s}} value are discussed. The role played by the {ital Z} quark width is stressed. It is also emphasized that high-energy (but not low-energy) corrections could significantly diminish the prediction. However, unless higher-dimension operators are assumed to be suppressed, at present one cannot place strong constraints on the superheavy spectrum. Nonleading electroweak threshold corrections are also discussed.
Guth Theory uses Higgs Monopoles

If magnetic monopoles exist at all, they may originate from a type of quantum mechanical field called a Higgs field. Higgs fields are an essential part of certain of the grand unified theories of physics, GUTs. It is nice that the so-called GUT theories can accommodate the production of monopoles in the formational processes of the universe. It is also nice that the GUT theories of particle physics can accommodate the origin of the universe at all. In a report of December's Eleventh Texas Symposium on Relativistic Astrophysics (Science, January 28, 1983), a paper by A. H. Guth of the Massachusetts Institute of Technology describes a new version of the ‘Big Bang—Big Crunch’ theory of the origin of the universe. Guth's theoretical model explains a number of questions raised previously about the Big Bang expansion and, in so doing, addresses the monopole question.
Assessment of COSMO-CLM Performances over Mediterranean Area

In this paper, the capabilities of COSMO CLM on simulating the main features of the observed climate over the whole Mediterranean area have been analyzed. The investigated period is 1971-2000. A simulation driven by ERA40 Reanalysis has been performed at a spatial resolution of 14 km in order to provide an assessment of regional model performance on local scale for impact studies. 2-metres mean temperature and total precipitation simulated values have been compared with E-OBS observational dataset; moreover, the total cloud cover has been validated with respect to the ERA-Interim Reanalysis.
Leaf and canopy level photosynthetic responses of French prune (Prunus domestica L. ‘French’) to stem water potential based deficit irrigation

SUMMARY The effects of full irrigation and two levels of water stress on tree physiology were investigated in a French prune orchard. The control treatment received approximately 100% of the estimated seasonal crop water requirements throughout the season. The moderate and severe water stress treatments were managed to decline from a fully watered status in late spring to a midday stem water potential of ‐1.5 and ‐2.0 MPa, respectively, by harvest. Water stress caused a clear reduction in stem water potential throughout the daylight period, as well as reductions in leaf conductance and photosynthesis, and all of these reductions were more severe with increasing water stress. In a moderate and severe stress treatment, the photosynthetic rate of fully exposed leaves was reduced to 90% and 81% respectively, of the control treatment. There was a linear decline in light saturated photosynthesis with a decline in stem water potential. However, the stress treatments also influenced leaf orientation and the resulting incident light distribution on leaves within the canopy, such that light was more uniformly distributed in canopies under water deprivation than it was under full irrigation. The overall effect of water stress was that the moderate and severe stress treatments had 101% and 93% respectively of calculated canopy photosynthesis compared with the control. This may account for the observed tolerance of prune production to deficit irrigation. A midday depression in assimilation was observed on most days in all treatments, but was not associated with feedback inhibition resulting from carbohydrate accumulation in leaves.
Beetles (Coleoptera) of Peru: A Survey of the Families. Carabidae

Diversity: 23 tribes, 131 genera, 721 species. The family Carabidae, commonly known as “Ground Beetles,” is one of the ten largest beetle families and is the largest family in the coleopteran suborder Adephaga. This family was erected by Latreille in 1802 at which time it contained 29 genera. Today, the Carabidae contains an estimated 39,000 described species, in ca. 100 tribes and 1860 genera (Lorenz, 2005). Modern classifications of the Carabidae include groups that were previously ranked as families, such as Cicindelidae, Omophronidae, Paussidae, and Rhysodidae. Recognition: All adult carabids possess three features which distinguish them from other terrestrial beetles: the hind coxae are fixed in place, the hind coxae divide the first visible sternite of the abdomen, and they have an internal pair of glands in the abdomen used for generating defense chemicals. These glands cannot be seen externally; however, their use produces distinctive and powerful sprays and odors in many carabid lineages. Two carabid lineages, the Brachinini and Paussinae, are known as “Bombardier and False bombardier beetles, respectively” since they have the ability to explosively discharge defensive chemicals at temperatures of 55–100uC (Aneshansley et al., 1969). This type of defensive system is unique among the beetles (Bousquet and Larochelle, 1993).
Sparse Modeling and Recursive Prediction of Space–Time Dynamics in Stochastic Sensor Networks

Wireless sensor network has emerged as a key technology for monitoring space–time dynamics of complex systems, e.g., environmental sensor network, battlefield surveillance network, and body area sensor network. However, sensor failures are not uncommon in traditional sensing systems. As such, we propose the design of stochastic sensor networks to allow a subset of sensors at varying locations within the network to transmit dynamic information intermittently. Realizing the full potential of stochastic sensor network hinges on the development of novel information-processing algorithms to support the design and exploit the uncertain information for decision making. This paper presents a new approach of sparse particle filtering to model spatiotemporal dynamics of big data in the stochastic sensor network. Notably, we developed a sparse kernel-weighted regression model to achieve a parsimonious representation of spatial patterns. Further, the parameters of spatial model are transformed into a reduced-dimension space, and thereby sequentially updated with the recursive Bayesian estimation when new sensor observations are available over time. Therefore, spatial and temporal processes closely interact with each other. Experimental results on real-world data and different scenarios of stochastic sensor networks (i.e., spatially, temporally, and spatiotemporally dynamic networks) demonstrated the effectiveness of sparse particle filtering to support the stochastic design and harness the uncertain information for modeling space–time dynamics of complex systems.
Feed-forward motor control of ultrafast, ballistic movements

To circumvent the limits of muscle, ultrafast movements achieve high power through the use of springs and latches. The time scale of these movements is too short for control through typical neuromuscular mechanisms, thus ultrafast movements are either invariant or controlled prior to movement. We tested whether mantis shrimp (Stomatopoda: Neogonodactylus bredini) vary their ultrafast smashing strikes and, if so, how this control is achieved prior to movement. We collected high-speed images of strike mechanics and electromyograms of the extensor and flexor muscles that control spring compression and latch release. During spring compression, lateral extensor and flexor units were co-activated. The strike initiated several milliseconds after the flexor units ceased, suggesting that flexor activity prevents spring release and determines the timing of strike initiation. We used linear mixed models and Akaike's information criterion to serially evaluate multiple hypotheses for control mechanisms. We found that variation in spring compression and strike angular velocity were statistically explained by spike activity of the extensor muscle. The results show that mantis shrimp can generate kinematically variable strikes and that their kinematics can be changed through adjustments to motor activity prior to the movement, thus supporting an upstream, central-nervous-system-based control of ultrafast movement. Based on these and other findings, we present a shishiodoshi model that illustrates alternative models of control in biological ballistic systems. The discovery of feed-forward control in mantis shrimp sets the stage for the assessment of targets, strategic variation in kinematics and the role of learning in ultrafast animals.
FAST CD Control at WetEnd & Unique Drainage Measurement

One of the greatest challenges faced by the papermaker is controlling and reducing product variations at their source, namely the wet-end. It has been extremely difficult, if not impossible, to date because of the lack of adequate sensors to measure process and product changes right on the wire. Honeywell-Measurex's new FullWebTM Advanced Systems Technology (FAST) and SpectraFoilTM sensor go a long way in addressing these concerns. Using a unique, non-scanning measurement technology, the SpectraFoil sensor can detect both product variation and process changes, reliably and virtually instantaneously. Specially developed FAST control applications put the measurement data to use to provide paper makers with significant economic and quality benefits.
THE IDENTIFICATION OF HYBRID PLANTS IN SEGREGATING POPULATIONS.

Various statistical procedures have been applied in analyses of natural and experimental introgression. Most of these procedures can be derived from Welch's (1939) discriminant function, although most were developed independently prior to Welch's suggestion. Welch proposed that the use of the likelihood ratio criterion itself was the best allocation procedure for the case with two alternative classes. Fisher's (1936, 1938) discriminant function and weighted and unweighted hybrid indices can be obtained directly from Welch's discriminant function by applying various simplifying assumptions.
MOLTEN METAL PROCESSING OF ADVANCED CAST ALUMINUM ALLOYS

Premium quality aluminum alloy castings are used extensively in various applications requiring a high strength-to-weight ratio, such as aerospace, automotive and other structural components. The mechanical properties in these structure-sensitive alloys are determined primarily by the secondary dendrite arm spacing and the morphology of interdendritic phases. In addition, the amount of porosity in the casting and the inclusion concentration have a strong influence on fracture, fatigue and impact properties. During the production of the casting, various molten metal processing techniques can be implemented to control these microstructural parameters. These melt treatments include grain refinement with Ti-B, eutectic modification with strontium or sodium, degassing with purge gases and filtration of inclusions. The efficiency of these treatments determines the quality of the cast component.
Phase transition in K2Cd2(SO4)3: Order parameter and microscopic distortions

The transition from P213(T4) to P212121(D24) in the langbeinite K2Cd2(SO4)3 has been analyzed using group theoretical methods and previously published structural data above and below the transition. We find that because the transition is strongly first-order, the primary-order parameter has relatively large values at the transition temperature, and higher order terms which involve the order parameter, the strain, and the coupling of the two must be included in the Landau expansion for the free energy. Complex displacements occur at the transition for all atoms of the unit cell, but these displacements can be resolved into contributions which can be shown from symmetry considerations to transform as the γ2Γ3 irrep of P21 3(T4) as well as contributions from symmetry-preserving displacements which transform under the irrep Γ1. Therefore, the transition is not a simple one and involves sulfate rotations and cadmium and potassium ion displacements.
Origin of In-Plane Texturing in Sputtered Mo Films

Sputtered Mo films with a thickness of 2μm or greater have been previously shown by xray and TEM studies to grow with strong in-plane and out-of-plane textures under dynamic deposition conditions. In this work, the geometric conditions and mechanisms causing preferential grain alignment in the plane of growth for sputtered Mo films, with a nominal thickness of 2μm, were explored. Four different deposition configurations, obtained by varying the parameters such as the deposition angle and the rotation speed of the substrates, were used in order to modify the texture as studied by x-ray and SEM techniques. While a [110] type out-of-plane texture was observed for all four deposition configurations, a (110) type in-plane texture , and the corresponding grain alignment in the plane of growth, was observed only when the flux of adatoms was hitting the substrates at an oblique angle. The texture characteristics and the microstructure of the Mo films, as analyzed using the pole figure x-ray and SEM techniques, were observed to be very similar for films deposited on three different substrates, namely the Si(100) and Ni 3 Al(321) single crystals, and laboratory grade glass slides. The in-plane texture development under oblique deposition conditions was proposed to be due to a combination of two mechanisms, namely the preferential resputtering of some of the grains normal to and in the plane of growth caused by the higher energy adatoms in the flux, followed by termination of the preferentially sputtered grains due to geometric shadowing.
Engineering Forest Trees with Heavy Metal Resistance Genes

Pollution of soil and water with heavy metals such as mercury, cadmium and arsenic, is a worldwide problem. Phytoremediation, the use of plants to remove, sequester or detoxify pollutants, including heavy metals, offers an environmentally-friendly alternative to engineering-based methods for remediation. Forest trees have multiple features that make them particularly useful for removal of toxic heavy metals, especially if they can be engineered with genes allowing them to handle high levels of these elements. Although still in its infancy, research with transgenic trees carrying genes allowing them to detoxify or sequester some heavy metals has already made promising progress. Most of the work to date has been performed using poplar species and hybrids, although other woody species could be equally as useful. Trees have been engineered with genes for the handling of mercury, cadmium, copper and arsenic following two main approaches, phytoextraction and phytotransformation/phytovolatilizaton. In vitro studies have shown the transgenic trees to have enhanced abilities to tolerate and/or accumulate these metals, and preliminary results from field tests indicate that the trees are functioning. New combinations of genes involved in metal transport or conversion may further enhance the heavy metal remediation capabilities of the transgenic trees. Given the environmentally friendly application, forest trees engineered for phytoremediation may be some of the first transgenic forest trees approved for operational deployment.
Operation Analysis and Improvement Measure of 500 kV Tank Circuit Breaker

500 kV tank circuit breaker has good anti-seismic performance,with an external line package type TA,compact configuration,small area and high reliability.However,in recent years,internal discharge faults of tank circuit breaker in Hebei Electric Power Corporation occurred frequently when 500 kV tank circuit breaker was being combined into grid.Through studying on fault phenomenon and experience from the laboratory,it is detected that internal discharge of tank circuit breaker is caused by impurities,so it is important to keep assembling condition clean and avoid the dropping of scraps during operation.At present,thoroughly cleaning up impurities at the bottom of tank circuit breaker is taken to keep inside cleaning.
Influence of the physical processing on the major allergen in soybean

Soybean contains much nutrition,and it is the main source of better plant- based protein for human,livestock and poultry.However,soybean is a common kind of food allergy. In this paper,the research of physical process in reducing soybean allergies was reviewed.The effect of physical process including heating,irradiation,high pressure,high voltage pulsed electric field and ultrasonic on the structure and allergenicity of the major allergen in soybean were also elaborated in detail. The review would provide the scientific basis for the development of non-allergic or hypoallergenic soybean products through physical processing.
Bacterial growth inhibition by amniotic fluid. VIII. Evaluation of a radiometric bioassay for rapid, in vitro demonstration of phosphate-sensitive bacterial growth inhibitor in amniotic fluid.

Abstract A radiometric bioassay based on the continuous monitoring of 14CO2 released from labeled glucose in the presence of amniotic fluid or amniotic fluid with added phosphate has been employed to detect the presence of a phosphate-sensitive bacterial inhibitor in amniotic fluid near term. The time required for detection of the inhibitory activity is approximately 12 hours, in contrast to approximately 36 hours required for a previously reported technique. AppHcation of this radiometric bioassay to demonstrate bacterial growth inhibition by amniotic fluid and physicochemical properties of the inhibitory activity yielded results comparabie to those obtained with the older method of plate counts of viable bacteria. By the new technique it was possible to demonstrate that the inhibitory activity was phoshate sensitive, heat stable, inactivated by metal chelation, removed by bentonite, and present in a low-molecular-weight fraction of amniotic fluid. (AM. J. OBSTET. GYNECOL. 135:14, 1979).
Effects of exposure to bisphenol A and ethinyl estradiol on the gut microbiota of parents and their offspring in a rodent model

ABSTRACTGut dysbiosis may result in various diseases, such as metabolic and neurobehavioral disorders. Exposure to endocrine disrupting chemicals (EDCs), including bisphenol A (BPA) and ethinyl estradiol (EE), especially during development, may also increase the risk for such disorders. An unexplored possibility is that EDC-exposure might alter the gut microbial composition. Gut flora and their products may thus be mediating factors for the disease-causing effects of these chemicals. To examine the effects of EDCs on the gut microbiome, female and male monogamous and biparental California mice (Peromyscus californicus) were exposed to BPA (50 mg/kg feed weight) or EE (0.1 ppb) or control diet from periconception through weaning. 16s rRNA sequencing was performed on bacterial DNA isolated from fecal samples, and analyses performed for P0 and F1 males and females. Both BPA and EE induced generational and sex-dependent gut microbiome changes. Many of the bacteria, e.g. Bacteroides, Mollicutes, Prevotellaceae...
Medial Displacement Calcaneal Osteotomy: A Comparison of Screw Versus Locking Plate Fixation.

Locking plate fixation is becoming more popular for fixation of lower extremity osteotomies. The present study evaluated locking plate fixation compared with screw fixation in the medial displacement calcaneal osteotomy procedure, measuring the outcomes and rate of hardware removal. The procedure was performed on 30 patients, 31 times, with 17 undergoing single screw fixation and 14 undergoing locking plate fixation. The return to activity was 6.87 ± 1.43 months, including some patients for whom running was their main activity. No malunions, nonunions, displacements, or infections developed. In 3 patients (21.4%), the locking plate was removed compared with 1 patient (5.9%) who required screw removal. The difference was not significant (p = .30). No differences were found in their postoperative American Orthopaedic Foot and Ankle Scale scores (91.9 ± 7.7 with plates versus 94.4 ± 5.8 with screws; p = .36). The Roles and Maudsley scores were the same in the 2 groups preoperatively at 4.0 ± 0.0, with the postoperative scores improving to 1.50 ± 0.5 and 1.41 ± 0.5 for the plate and screw group, respectively (p = .62). No significant increase was seen for patients undergoing hardware removal, regardless of the adjunctive procedure used (i.e., flexor digitorum longus/Kidner, Lapidus or midfoot fusion, subtalar arthroereisis, and endoscopic gastrocnemius recession). The stage of posterior tibialis dysfunction had no significant difference in the postoperative scores. From the results of the present study, we have concluded that using a locking plate or a single screw for fixation of the medial displacement calcaneal osteotomy provides acceptable patient outcomes and that the differences in the rate of hardware removal were not statistically significant between the 2 groups.
Highly Coarse-Grained Representations of Transmembrane Proteins

Numerous biomolecules and biomolecular complexes, including transmembrane proteins (TMPs), are symmetric or at least have approximate symmetries. Highly coarse-grained models of such biomolecules, aiming at capturing the essential structural and dynamical properties on resolution levels coarser than the residue scale, must preserve the underlying symmetry. However, making these models obey the correct physics is in general not straightforward, especially at the highly coarse-grained resolution where multiple (∼3–30 in the current study) amino acid residues are represented by a single coarse-grained site. In this paper, we propose a simple and fast method of coarse-graining TMPs obeying this condition. The procedure involves partitioning transmembrane domains into contiguous segments of equal length along the primary sequence. For the coarsest (lowest-resolution) mappings, it turns out to be most important to satisfy the symmetry in a coarse-grained model. As the resolution is increased to capture more det...
Higher Incidence of Venous Thromboembolism Is Associated with Initial Cycles of Chemotherapy in Lymphoma Patients: Creatinine and Hemoglobin as Key Risk Factors.

Background: While Lymphoma patients are at increased risk of venous thromboembolism (VTE), the timing of VTE occurrence in reference to chemotherapy (CT) and risk factors are not well defined. Methods: Medical records of all newly referred lymphoma patients (1046) to MD Anderson Cancer Center (MDACC) in 2003 were retrospectively reviewed over a follow-up period of two years for demographics, tumor histology, laboratory values, CT regimens, incidence of VTE, risk factors and management of VTE. Results: Four hundred and twenty-two (422) out of 1046 patients received at least one cycle of CT at MDACC (total CT cycles 2126). The median age of the patients was 57 years (range, 17 to 87). Fifty eight % of pts were male and 62% were newly diagnosed. Seventy-three patients (17.3%) out of 422 had 80 new episodes of VTE; 58 deep vein thromboses (DVT) only, 17 pulmonary embolisms (PE) only, and 5 were combined DVT and PE. Only less than 5% (20/422) of pts received thromboprophylaxis during treatment for lymphoma. Interestingly, 68% (54/80) of episodes occurred by cycle 3 of CT suggesting that VTE episodes occurred primarily in patients with highest disease burden or during initiation of CT. Since the incidence was highest during the initial cycles of CT, we analyzed risk factors for the first regimen of CT. By multivariate logistic regression analysis, gender (female vs. male, OR=3.6, 95%CI 1.707 to 7.61, p=0.0008), high hemoglobin (OR=1.29, 95%CI 1.059 to 1.561, p =0.011), high serum creatinine (OR=3.36, 95%CI 1.372 to 8.228, p=0.0080), doxorubicin (DOX) and/or methotrexate (MTX)-based CT regimen (OR=2.948, 95%CI 1.352 to 6.429, p=0.0066) were found to be important risk factors for new VTE. Specifically, the estimated risk for lymphoma patients with baseline hemoglobin 12 gm/dL receiving DOX and/or MTX based CT with renal insufficiency (creatinine 2.0mg/dL) is 50% in females and 21% in males. Conclusions: Lymphoma patients are at higher risk for VTE in the initial cycles of CT (cycles 1–3). Patients with high hemoglobin, elevated creatinine, female gender, and those receiving DOX and/or MTX based CT regimens are at higher risk for VTE than others. These clinically relevant findings suggest that a thromboprophylaxis strategy is needed in the patients presenting with these risk factors, particularly, in the initial cycles of chemotherapy.
Surviving graduate school

Anyone who has done a PhD knows that you go through an educational phase transition. You are no longer instructed by others, but instead teach yourself. You cease acquiring basics and begin assimilating values and behaviours that allow you to participate in the scientific way of life. It is an apprenticeship that cannot be condensed into a set of rules.
Pruritic Rash in Pregnancy.

A pregnant woman presented with scattered periumbilical and lower extremity pruritic papules.
W -Algebras and Langlands-Drinfeld Correspondence

The W-algebras, associated to arbitrary simple Lie algebras, are defined as the cohomologies of certain BRST complexes. This allows to prove many important facts about them, such as determinant formulas, duality and free field resolutions for generic values of the central charge. A classical limit of a W-algebra can be identified with the center of the universal enveloping algebra of the corresponding affine Kac-Moody algebra. This gives some information on the geometric Langlands-Drinfeld correspondence for complex algebraic curves.
Cloud driven design of a distributed genetic programming platform

We describe how we design FlexGP, a distributed genetic programming (GP) system to efficiently run on the cloud. The system has a decentralized, fault-tolerant, cascading startup where nodes start to compute while more nodes are launched. It has a peer-to-peer neighbor discovery protocol which constructs a robust communication network across the nodes. Concurrent with neighbor discovery, each node launches a GP run differing in parameterization and training data from its neighbors. This factoring of parameters across learners produces many diverse models for use in ensemble learning.
Failure of Differentiation of Parts

The most widely accepted classification of congenital limb anomalies was pioneered by Frantz and O’Rahilly [1] and published by Swanson [2]. This work eliminated much of the confusing Greek and Latin terminology and was accepted by the American Society for Surgery of the Hand, International Federation of Societies for Surgery of the Hand, and International Society for Prosthetics and Orthotics. This system is based on embryonic failure during development and relies upon clinical diagnosis for categorization. Each limb malformation is classified according to the most predominant anomaly and placed into one of seven categories (Table 7.1). Different clinical presentations of similar categories of embryonic failures are explained by varying degrees of damage within the organization of the limb mesenchyme [2, 3].
Villains, Victims, and Heroes in Character Theory and Affect Control Theory:

We examine three basic tropes—villain, victim, and hero—that emerge in images, claims, and narratives. We compare recent research on characters with the predictions of an established tradition, aff...
Li 6 ( n , t ) He 4 Reaction at Intermediate Energies

The ${\mathrm{Li}}^{6}(n, t){\mathrm{He}}^{4}$ reaction cross section has been measured in a neutron energy interval extending from 9 kev to 340 kev. The cross section descends from 1.77 barns at 9 kev to a minimum of 0.74 b at 100 kev before rising to a peak resonance value of 2.75 barns at 258 kev. The cross section from 9 kev to 90 kev is not proportional to ${E}^{\ensuremath{-}\frac{1}{2}}$, but can be represented by $\ensuremath{\sigma}=3.96{E}^{\ensuremath{-}0.367}$ with $\ensuremath{\sigma}$ in barns and the neutron energy $E$ in kev. Angular distributions of the tritons are presented for neutron energies of 150, 200, 258, 300, 350, and 565 kev. These distributions, measured in a relative manner, are placed on an absolute scale by normalizing to the cross section data of this experiment, extended to 565 kev by use of previously measured cross sections.
The Haunted Dublin of Ulysses: Two Modes of Time in the Second City of the Empire

In Ulysses, and in the ‘Wandering Rocks’ episode specifically, James Joyce depicts the events occurring in Dublin on 16 June 1904 as unfolding according to the logic of two different temporal orders. On the one hand, coincidence structures the narrative to position individual characters alongside others and to render their shared moments significant in a style typical of national imagining. On the other hand, figural time marks Joyce’s Dublin as a colonial city rooted in older forms of social order and structural power than the dictates of modern capitalism and national belonging that epitomise citizenship in the capitals of independent states. These two modes of time collide when the ghost of Charles Stewart Parnell returns to Dublin in ‘Wandering Rocks.’ At one and the same time, the Irish of this novel connect to one another through the imaginative work that characterises national belonging, and they relate to one another through a type of city life that has developed according to the logic of colonialism. As Joyce’s Dubliners go about their day together, their inner lives follow a figural pattern structured by memory and expectation. When Parnell’s ghost becomes the focus of this temporal order marked by insistent recalling and constant waiting, the novel suggests a form of political longing in the colonial city that parallels the forms of sexual and commercial desire motivating and disappointing so many of the characters in Joyce’s text. By setting Dublin, the second city of the British Empire, within two different modes of time in Ulysses, Joyce presents the view of Dublin that he has at the time of the novel’s publication—a national capital that has yet to give up the ghost of its colonial oppression.
Helicoverpa zea (Lepidoptera: Noctuidae) Oviposition and Larval Vertical Distribution in Bt Cotton Under Different Levels of Nitrogen and Irrigation.

In some Bt cotton (Gossypium hirsutum L.) varieties, bollworm (Helicoverpa zea Boddie) larval behavior differs from non-Bt varieties. Laboratory assays indicate bollworm larvae can detect Bt proteins, which may cause behavioral differences. Plant stress from factors including fertility and water availability causes changes in plant physiology and Bt expression. Our objective was to determine whether nitrogen and irrigation influenced bollworm behavior in Bt cotton by recording the vertical distribution of eggs and larvae over time. We conducted small plot experiments with Cry1Ac + Cry1F cotton in 2016 and 2017 with three nitrogen rates, along with irrigated and nonirrigated treatments during 2017. Bollworm locations were determined by in-field examination of 10–20 cotton plants per plot over 6–8 wk. The location of each egg and larva was recorded by node, with instar estimation of each larva. Oviposition was higher in in plots receiving nitrogen; first and second instars were also more common in plots receiving nitrogen or irrigation, whereas older instars had similar numbers among treatments. Oviposition was more evenly distributed throughout the canopy earlier in the sampling period than during later weeks, with more eggs in the top third of the canopy in only three of 14-wk. Early instars were also evenly distributed throughout the canopy. Later, instars moved to the middle portions of the canopy, away from bottom nodes, and did not move toward the terminal. Understanding bollworm behavior can inform both crop scouting and resistance management decisions.
High strain rate response of bio-composites using split Hopkinson pressure bar and digital image correlation technique

ABSTRACTIn this research, high strain rate response and energy absorption characteristics under dynamic compression loading of five different bio-composites were studied using a compression split H...
Data-Driven Prognostics of Lithium-Ion Rechargeable Battery using Bilinear Kernel Regression

Reliability of lithium-ion (Li-ion) rechargeable batteries has been recognized as of high importance from a broad range of stakeholders, including battery manufacturers, manufacturers of battery-powered devices, regulatory agencies, researchers, and the public. Assessing the current and future health of Li-ion batteries is essential to ensure the batteries operate safely and reliably throughout their lifetime. This paper presents a new data-driven approach for prediction of battery remaining useful life (RUL) in the presence of corruptions (or errors) in capacity features. The approach leverages bilinear kernel regression to build a nonlinear mapping between the capacity feature space and the RUL state space. Specific innovations of the approach include: i) a general framework for robust sparse prognostics that effectively incorporates sparsity into kernel regression and implicitly compensates for errors in capacity features; and ii) two numerical procedures for error estimation that efficiently derives optimal values of the regression model parameters. Results of 10 years’ continuous cycling test on Li-ion prismatic cells suggest that the proposed approach achieves robust RUL prediction despite random noise in the capacity features.
A systematic review of mHealth funded R&D activities in EU: Trends, technologies and obstacles.

Objective: This study provides a systematic review of EU-funded mHealth projects. Methods: The review was conducted based mainly on the Projects and Results service provided by the EU Open Data Por...
Specificity in the biosynthesis of the universal tRNA nucleoside N6-threonylcarbamoyl adenosine (t6A)-TsaD is the gatekeeper.

N 6-threonylcarbamoyl adenosine (t6A) is a nucleoside modification found in all kingdoms of life at position 37 of tRNAs decoding ANN codons, which functions in part to restrict translation initiation to AUG and suppress frameshifting at tandem ANN codons. In Bacteria the proteins TsaB, TsaC (or C2), TsaD, and TsaE, comprise the biosynthetic apparatus responsible for t6A formation. TsaC(C2) and TsaD harbor the relevant active sites, with TsaC(C2) catalyzing the formation of the intermediate threonylcarbamoyladenosine monophosphate (TC-AMP) from ATP, threonine, and CO2, and TsaD catalyzing the transfer of the threonylcarbamoyl moiety from TC-AMP to A37 of substrate tRNAs. Several related modified nucleosides, including hydroxynorvalylcarbamoyl adenosine (hn6A), have been identified in select organisms, but nothing is known about their biosynthesis. To better understand the mechanism and structural constraints on t6A formation, and to determine if related modified nucleosides are formed via parallel biosynthetic pathways or the t6A pathway, we carried out biochemical and biophysical investigations of the t6A systems from E. coli and T. maritima to address these questions. Using kinetic assays of TsaC(C2), tRNA modification assays, and NMR, our data demonstrate that TsaC(C2) exhibit relaxed substrate specificity, producing a variety of TC-AMP analogs that can differ in both the identity of the amino acid and nucleotide component, whereas TsaD displays more stringent specificity, but efficiently produces hn6A in E. coli and T. maritima tRNA. Thus, in organisms that contain modifications such as hn6A in their tRNA, we conclude that their origin is due to formation via the t6A pathway.
Obtaining Public Opinion About sUAS Activity in an Urban Environment

Members of the public completed a short survey to complement a larger flight demonstration and data collection exercise in Corpus Christi, Texas. Respondents were invited to share their concerns and were asked about their knowledge of small Unmanned Aerial System (sUAS) operations. Participants were familiar with sUAS operations and reported feeling moderately comfortable with urban area operations, reflecting this in opinions that sUAS are as safe as other modes of transport. Compared to other UAS opinion surveys, participants gave similar responses to affect questions but were more knowledgeable concerning sUAS operational regulations. At first exposure to these live sUAS flights, participants reported positive impressions about the traffic management system that was being demonstrated.
Spaceflight induces oxidative damage to blood-brain barrier integrity in a mouse model

Many factors contribute to the health risks encountered by astronauts on missions outside Earth's atmosphere. Spaceflight-induced potential adverse neurovascular damage and late neurodegeneration are a chief concern. The goal of the present study was to characterize the effects of spaceflight on oxidative damage in the mouse brain and its impact on blood-brain barrier (BBB) integrity. Ten-week-old male C57BL/6 mice were launched to the International Space Station (ISS) for 35 days as part of Space-X 12 mission. Ground control (GC) mice were maintained on Earth in flight hardware cages. Within 38 ± 4 hours after returning from the ISS, mice were euthanized and brain tissues were collected for analysis. Quantitative assessment of brain tissue demonstrated that spaceflight caused an up to 2.2-fold increase in apoptosis in the hippocampus compared to the control group. Immunohistochemical analysis of the mouse brain revealed an increased expression of aquaporin4 (AQP4) in the flight hippocampus compared to the controls. There was also a significant increase in the expression of platelet endothelial cell adhesion molecule-1 (PECAM-1) and a decrease in the expression of the BBB-related tight junction protein, Zonula occludens-1 (ZO-1). These results indicate a disturbance of BBB integrity. Quantitative proteomic analysis showed significant alterations in pathways responsible for neurovascular integrity, mitochondrial function, neuronal structure, protein/organelle transport, and metabolism in the brain after spaceflight. Changes in pathways associated with adhesion and molecular remodeling were also documented. These data indicate that long-term spaceflight may have pathological and functional consequences associated with neurovascular damage and late neurodegeneration.
Toward uncharted territory of cellular heterogeneity: advances and applications of single-cell RNA-seq

Among single-cell analysis technologies, single-cell RNA-seq (scRNA-seq) has been one of the front runners in technical inventions. Since its induction, scRNA-seq has been well received and undergone many fast-paced technical improvements in cDNA synthesis and amplification, processing and alignment of next generation sequencing reads, differentially expressed gene calling, cell clustering, subpopulation identification, and developmental trajectory prediction. scRNA-seq has been exponentially applied to study global transcriptional profiles in all cell types in humans and animal models, healthy or with diseases, including cancer. Accumulative novel subtypes and rare subpopulations have been discovered as potential underlying mechanisms of stochasticity, differentiation, proliferation, tumorigenesis, and aging. scRNA-seq has gradually revealed the uncharted territory of cellular heterogeneity in transcriptomes and developed novel therapeutic approaches for biomedical applications. This review of the advancement of scRNA-seq methods provides an exploratory guide of the quickly evolving technical landscape and insights of focused features and strengths in each prominent area of progress.