cssi/SciSciGPT-SciSciNet huggingface dataset:
Fulvestrant (F) in metastatic breast cancer: Standard dose (Std) vs loading dose (Ld)--A retrospective study

10575 Background: Fulvestrant is shown to be an effective hormonal agent in menopausal hormone-receptor positive metastatic breast cancer (MBC) patients. This study aimed at showing if Ld of fulvestrant will improve its efficacy over the FDA approved Std schedule. Methods: We retrospectively reviewed our pharmacy electronic database over a period of two years to identify MBC patients who were treated with fulvestrant. Patients received either Std of 250 mg IM on day (d) 1 and repeated Q28d or Ld of 500 mg IM d1 and 15 and Std on d28 which was repeated every 28 days until evidence of progression. All medical records were reviewed and responses were recorded as improved disease (ID), stable disease (SD), or progressive (PD) as documented by the treating oncologist. Time to response (TTR) (the interval from first injection until response) as well the duration of response (DR), was determined. Results: Medical records of 157 consecutive, evaluable patients who received F for their MBC were identified and revi...
Preparation of magnesium-substituted LiTaO3 films by the sol-gel method

Des couches minces Li 1-x Mg x/2 TaO 3 (x = 0 a 0,20) avec et sans orientation preferentielle ont ete preparees a partir de solutions alcoxydes.
Iodide-induced thyrotoxicosis in Boston.

Abstract The syndrome of iodide-induced hyperthyroidism (Jodbasedow) is not common and has been reported to occur in patients with iodine-deficient goiter after iodide replenishment. As part of a larger study to assess the effects of iodide administration on thyroid hormone synthesis in normal subjects and in patients with various underlying disorders of the thyroid, iodides (5 drops of a saturated solution of potassium iodide) were administered to eight patients with nontoxic goiter residing in Boston, an area of iodine sufficiency. Hyperthyroidism developed during and after iodide administration in four of the eight — an unexpectedly high frequency. This finding suggests that the homeostatic mechanism controlling thyroid hormone synthesis and release in these patients is not functioning normally. We recommend that large doses of iodides not be administered to patients with nontoxic goiter.
Notes on a Generic Parachute Opening Force Analysis

This paper develops a generic opening shock analysis that permits calculation of velocity profiles, shock factors, maximum shock forces and their time of occurrence during deployment for many types of parachutes. Criteria are presented and methods of calculation developed. Application of the analysis to an apparent anomaly in solid cloth parachute finite mass deployment, verifies the parachute diameter effect shown in the test performance. This is illustrated by an example.
Closure of an Unlined Evaporation Pond: a Case History

In 1985, the Fort Worth District, Corps of Engineers, successfully permitted and executed the closure of an unlined evaporation pond at the Longhorn Army Ammunition Plant in east Texas. The pond, constructed in 1963 at the site of an active explosive waste-burning ground area, had been used to store explosive wastes resulting from the washout of rocket motor casings and solvent residues from operations involving pyrotechnic material preparation and mixing. Because operation of the unlined evaporation pond appeared to be primarily responsible for locally contaminating the ground water, the Army ceased operation of the pond in 1984 and began formal closure activities for the unit as a Resource Conservation and Recovery Act (RCRA) interim status surface impoundment. Under Phase I of the closure contract, a total of 1,877,113 gal of wastewater was removed and shipped via tank truck to a permitted disposal well some 80 mi from the site. The Phase II contract consisted of removal and transporting of contaminated sludges and soils to a permitted hazardous waste disposal site, backfilling the pond, installing a filter drain system, and turfing. A total of 8,116 yd 3 of material was excavated and shipped from the site.
Improvement of Sugar Production from Transgenic Switchgrass with Low-Temperature Alkali Pretreatment

Genetically modified switchgrass (cv. Alamo) and its conventional plant were both pretreated using two groups of conditions: lime at 50 °C and the combination of lime and NaOH at ambient temperature. The results show that the transgenic plant (with altered lignin content and composition) was more susceptible to alkali pretreatment than the conventional plant. At the recommended conditions (0.1 g/g of raw biomass and 12 h) for lime pretreatment at 50 °C, the glucan and xylan conversions of transgenic switchgrass were 12 and 10%, respectively, higher than those of the conventional plant. These increases were reduced to 7 and 8% for glucan and xylan conversions, respectively, when the best conditions (0.025 g of lime/g of raw biomass, 0.1 g of NaOH/g of raw biomass, and 6 h) for combined alkali pretreatment at ambient temperature were employed. The advantage of transgenics over a conventional plant in sugar production could be maximized if proper pretreatment conditions were used.
The cleaner prodution practice of little nitrogen

The projects in Yuanjiang city nitrogen fertilzer plant, such as clased cirulation of the waste water, tail gas recovery, waste residue comprehensive utilizarion, etc, was introduced in this paper. The article has described the production technology, pollution sources of factory and blowdown characteristic.
Pesticides used against Cydia pomonella disrupt biological control of secondary pests of apple

Abstract The effects of codling moth (Cydia pomonella (Linnaeus)) (Lepidoptera: Tortricidae) management programs on secondary pests of apple were examined from 2008 to 2011 in five replicated large-plot trials. The orchards were chosen for a history of Eriosoma lanigerum (Hausmann) (Hemiptera: Aphididae) and tetranychid mite outbreaks. Programs covered the first, second, or both generations of C. pomonella, and employed some of the newer insecticides for comparison to older materials. Increased levels of E. lanigerum were consistently associated with the use of spinetoram and novaluron throughout the tests. The mechanism of disruption was not completely clear, but suppression of Forficula auricularia Linnaeus (Dermaptera: Forficulidae) and Aphelinus mali (Haldeman) (Hymenoptera: Aphelinidae) were associated with the use of these materials. Methoxyfenozide, chlorantraniliprole, and azinphos-methyl did not disrupt biological control of tetranychid mites or aphids, and negative effects on natural enemies were infrequent. Lambda-cyhalothrin provided direct control of aphid species, thus reduced levels of natural enemies could also be ascribed to lack of prey. The effect of some of the insecticide applications made during the first generation were evident for many months after the application in terms of pest and natural enemy populations; however, attempts to mitigate disruptive effects by shifting the use of materials to the second generation of C. pomonella were not successful. The effect on biological control of tetranychid mites was less consistent, although some detrimental effects (increased pest or decreased predatory mite levels) were associated with spinetoram, novaluron, and lambda-cyhalothrin. The difficulties in sampling natural enemies and determining their impact made pest outbreaks the most reliable indicator of pesticide-induced disruption.
Mitogenic stimulation alters the regulation of LDL receptor gene expression in human lymphocytes

To address the possibility that influences other than ambient cholesterol concentrations regulate low density lipoprotein (LDL) receptor expression, the effect of mitogenic activation on the levels of LDL receptor mRNA in human lymphocytes was examined. Mitogenic stimulation of freshly isolated human peripheral blood mononuclear cells (PBMC) cultured in medium containing saturating concentrations of LDL resulted in cell cycle entry as evidenced by increased levels of mRNA for the interleukin-2 receptor, and also increased LDL receptor mRNA levels by 9-fold. Whereas LDL receptor gene expression was also induced when resting control PBMC were incubated in lipoprotein-deficient medium, mitogenic activation of PBMC cultured in the absence of LDL stimulated a further 3-fold increase in LDL receptor mRNA levels. The increase in LDL receptor mRNA levels in mitogen-stimulated PBMC was dependent on continued protein synthesis, was not the result of mRNA stabilization, and therefore most likely reflected enhanced gene transcription. It was unlikely that the increase in LDL receptor mRNA levels observed in mitogen-stimulated cells related merely to sterol deprivation since suppression of endogenous cholesterol synthesis with lovastatin increased LDL receptor mRNA only modestly. Moreover, mitogen-stimulated PBMC continued to synthesize cholesteryl esters, a storage form of cholesterol, confirming that they were not functionally deprived of sterols. Although mitogenic stimulation increased LDL receptor mRNA levels in PBMC, regulation by exogenous LDL was observed. Thus, LDL down-regulated LDL receptor gene expression in both control and mitogen-stimulated PBMC. Down-regulation was less effective in the latter; however, LDL down-regulated endogenous sterol synthesis to an equivalent extent in both control and mitogen-stimulated PBMC. By contrast, the oxygenated sterol, 25-hydroxycholesterol, and mevalonate, the precursor of endogenously synthesized sterols, down-regulated LDL receptor mRNA levels comparably in mitogen-stimulated and control PBMC. These data indicate that mitogenic stimulation provides an additional stimulus for LDL receptor gene expression over and above that of ambient sterols and, therefore, suggest that signals transduced during cellular activation play a role in regulation of LDL receptor mRNA levels.
Role of Conservation Adoption Premiums on Participation in Water Quality Trading Programs

Over half of lakes, reservoirs, and ponds in the United States are threatened or impaired, mostly by nutrients. One policy to improve water quality is water quality trading (WQT). While the concept is appealing, adoption of conservation practices in these programs has been anemic at best. Using a case study in the newly-formed WQT market in Jordan Lake, North Carolina, we propose that part of the problem is a large adoption premium (AP) for this program. AP is the amount that farmers require over and above direct adoption costs to participate. In this study, farmers were asked at in-person interviews about their willingness to accept (WTA) a payment to adopt a particular conservation practice (riparian buffers) in order to generate and sell credits. We compared farmers’ WTA to their direct cost of participation, which allowed us to estimate an AP. On average, the AP more than doubles the cost of purchasing credits. The AP sums all of the known indirect costs already cited in the literature, and more, into a single value and is relatively simple to estimate. Knowing the AP would improve the ability of policy makers to accurately estimate what is needed to boost adoption rates in WQT programs and other conservation programs as well.
Physiology and psychology

The nineteenth century was a time of great change in Europe and America. Agricultural reforms ensured a steady food supply, and improvements in public hygiene decreased fatalities from contagious diseases such as cholera. The population of Europe increased from about 140 to 420 million people between 1750 and 1900, with many congregated in the new urban centers. The dramatic expansion of industry led to a general increase in wealth, although the insecurities of the capitalist state (with periods of boom followed by periods of economic downturn) led some to question a system in which most of the wealth was owned by a privileged few and to look to alternative political systems such as socialism and communism. New developments in transportation and communication saw the spread of modern road networks, railways, canals, ocean lines, and telegraph and postal systems (Jansz, 2004). The nineteenth century witnessed the growth and increasing political strength of the middle class, whose long struggle to attain voting rights eventually bore fruit, although throughout most of the nineteenth century real political control remained in the hands of the conservative aristocracy. In the reactionary period following the Napoleonic wars in Europe, which ended with Napoleon's defeat at the battle of Waterloo in 1815, naturalistic approaches to psychology were repressed through censorship and the secret police. Nobody who promoted such views could hold a professorship in Europe and America in the early half of the century, and in the years immediately following 1815, advocacy of such views was punishable by imprisonment in some parts of Europe (Reed, 1997). As noted earlier, Joseph Priestley (1733–1804) was hounded out of Britain for his promotion of Hartley's associationist psychology as materialist psychology. Erasmus Darwin (1731–1802), the grandfather of Charles Darwin (1809–1882), who developed an early naturalistic evolutionary theory in Zoonomia (1794–1796), found his work suppressed. One of Darwin's followers, the British surgeon William Lawrence (1783–1867), published his theory that insanity is a neurophysiological disorder in Lectures on Physiology, Zoology and the Natural History of Man (1819). The medical establishment forced him to withdraw his book, and he lost his lectureship at the Royal College of Surgeons (Reed, 1997).
Critical analysis of multi-antenna systems in the LTE downlink

Long Term Evolution (LTE) is an emerging 4G wireless access technology. It is showing a lot of promise in field trials and gaining acceptance among the major wireless vendors such as Verizon-Vodafone, NTT-Docomo, KDDI, China Mobile, T-Mobile and others. Multi-Antenna or Multiple-Input Multiple-Output (MIMO) systems which involve the use of more than one antenna at the transmitter and receiver are a primary enabler of the high spectral efficiency and data rate sought to be achieved by LTE. This paper is novel in the following 2 aspects: A) It provides deep physical interpretations into the function and performance of MIMO in LTE. Such insights would not have been published elsewhere in the literature B) Performance evaluation of MIMO obtained from simulation results based on a full fidelity implementation of the latest version of the LTE Radio Interface standards (3GPP TS 36.211 and 36.213). MIMO performance is explained for various ITU channel models (Pedestrian A, Vehicular A, Typical Urban), Doppler spreads (5, 70, 300Hz) and antenna correlation conditions (High, Low). The treatment is fully complaint with the specifications laid down in the LTE performance standards 3GPP TS 36.101 and 36.104. The simulated MIMO performance is compared against a twofold system: Theoretical expectations that are derived in this paper and LTE 3GPP performance benchmarks. The author has also compared simulated results with data provided by the LTE-SAE Trial Initiative (LSTI) an industry partnership of telecom vendors and operators. The data show a close match. Due to its proprietary nature, such data is not shown in this paper. Readers with access to LSTI data are encouraged to compare them with results provided in this paper.
Recent Technical Trends in Direct Expansion Solar Heat Pump Systems

ABSTRACT This paper describes the recent technical trends on direct expansion solar heat pump systems. As for the simulation of the system, two papers are mentioned which deal with the comparisons between the system with covered collectors and the one with bare collectors. In order to improve the performance of these systems under low insolation or at night, a number of researches on collectors for an evapolator or a variable capacity compressor are carried out. Two systems have been on the market in Japan; one is a heating/cooling system for commercial building use, and the other is a hot water supply system for domestic use. Lastly this paper refers to a paper on a system using collector which is integrated into the house structure so as to accord with the archtecture and to reduce total initial cost.
Abstract 3114: MicroRNA-205 signaling regulates mammary stem cell fate and tumorigenesis

Dysregulation of epigenetic controls is associated with tumorigenesis in response to microenvironmental stimuli; however, the regulatory pathways involved in epigenetic dysfunction are largely unclear. We have determined that a critical epigenetic regulator, microRNA-205 (miR-205), is repressed by the ligand jagged1, which is secreted from the tumor stroma to promote a cancer-associated stem cell phenotype. Knockdown of miR-205 in mammary epithelial cells promoted epithelial-mesenchymal transition (EMT), disrupted epithelial cell polarity, and enhanced symmetric division to expand the stem cell population. Furthermore, miR-205-deficient mice spontaneously developed mammary lesions, while activation of miR-205 markedly diminished breast cancer stemness. These data provide evidence that links tumor microenvironment and microRNA-dependent regulation to disruption of epithelial polarity and aberrant mammary stem cell division, which in turn leads to an expansion of stem cell population and tumorigenesis. This study elucidates an important role for miR-205 in the regulation of mammary stem cell fate, suggesting a potential therapeutic target for limiting breast cancer genesis. Citation Format: Meng-Ju Wu, Chun-Ju Chang. MicroRNA-205 signaling regulates mammary stem cell fate and tumorigenesis. [abstract]. In: Proceedings of the 106th Annual Meeting of the American Association for Cancer Research; 2015 Apr 18-22; Philadelphia, PA. Philadelphia (PA): AACR; Cancer Res 2015;75(15 Suppl):Abstract nr 3114. doi:10.1158/1538-7445.AM2015-3114
Sustaining Community Partnership Across Transition in District Leadership

This case of district turnover was developed as part of a project with state leaders and funders supporting local early education systems development. Understanding strategic and reactive activitie...
Discriminative dictionary learning to learn effective features for detecting buried threats in ground penetrating radar data

The ground penetrating radar (GPR) is a popular remote sensing modality for buried threat detection. In this work we focus on the development of supervised machine learning algorithms that automatically identify buried threats in GPR data. An important step in many of these algorithms is feature extraction, where statistics or other measures are computed from the raw GPR data, and then provided to the machine learning algorithms for classification. It is well known that an effective feature can lead to major performance improvements and, as a result, a variety of features have been proposed in the literature. Most of these features have been handcrafted, or designed through trial and error experimentation. Dictionary learning is a class of algorithms that attempt to automatically learn effective features directly from the data (e.g., raw GPR data), with little or no supervision. Dictionary learning methods have yielded state-of-theart performance on many problems, including image recognition, and in this work we adapt them to GPR data in order to learn effective features for buried threat classification. We employ the LC-KSVD algorithm, which is a discriminative dictionary learning approach, as opposed to a purely reconstructive one like the popular K-SVD algorithm. We use a large collection of GPR data to show that LC-KSVD outperforms two other approaches: the popular Histogram of oriented gradient (HOG) with a linear classifier, and HOG with a nonlinear classifier (the Random Forest).
Virtue Ethics is Empirically Adequate: A Defense of the Caps Response to Situationism

According to situationists, the available empirical psychological data show that prevalent conceptions of virtue are ‘empirically inadequate.’ The charge is ambiguous. I begin by differentiating four families of empirical inadequacy charges, explaining the conceptual connections among the families, and showing how different situationists press different versions of the charges from each family. Then I explain how the empirical psychological model known as the ‘cognitive affective personality system,’ or ‘CAPS model,’ enables distinct responses to these varied charges. The CAPS response has come under fire, though, and I close by responding to the five main challenges raised against it.
Modifier genes: Moving from pathogenesis to therapy

This commentary will focus on how we can use our knowledge about the complexity of human disease and its pathogenesis to identify novel approaches to therapy. We know that even for single gene Mendelian disorders, patients with identical mutations often have different presentations and outcomes. This lack of genotype-phenotype correlation led us and others to examine the roles of modifier genes in the context of biological networks. These investigations have utilized vertebrate and invertebrate model organisms. Since one of the goals of research on modifier genes and networks is to identify novel therapeutic targets, the challenges to patient access and compliance because of the high costs of medications for rare genetic diseases must be recognized. A recent article explored protective modifiers, including plastin 3 (PLS3) and coronin 1C (CORO1C), in spinal muscular atrophy (SMA). SMA is an autosomal recessive deficit of survival motor neuron protein (SMN) caused by mutations in SMN1. However, the severity of SMA is determined primarily by the number of SMN2 copies, and this results in significant phenotypic variability. PLS3 was upregulated in siblings who were asymptomatic compared with those who had SMA2 or SMA3, but identical homozygous SMN1 deletions and equal numbers of SMN2 copies. CORO1C was identified by interrogation of the PLS3 interactome. Overexpression of these proteins rescued endocytosis in SMA models. In addition, antisense RNA for upregulation of SMN2 protein expression is being developed as another way of modifying the SMA phenotype. These investigations suggest the practical application of protective modifiers to rescue SMA phenotypes. Other examples of the potential therapeutic value of novel protective modifiers will be discussed, including in Duchenne muscular dystrophy and glycerol kinase deficiency. This work shows that while we live in an exciting era of genomic sequencing, a functional understanding of biology, the impact of its disruption, and possibilities for its repair have never been more important as we search for new therapies.
High-resolution dynamic 31P-MRSI using a low-rank tensor model

Purpose:To develop a rapid 31P-MRSI method with high spatiospectral resolution using low-rank tensor-based data acquisition and image reconstruction.Methods:The multidimensional image function of 31P-MRSI is represented by a low-rank tensor to capture the spatial–spectral–temporal correlations of da
Façade retrofitting: from energy efficiency to climate change mitigation

Abstract Since climate changes are now evident, it is not only important to achieve high level of energy efficiency, but also to think about retrofit actions in order to mitigate the natural hazard impacts and to make buildings resilient. The paper focuses on climate change effects in summer and investigates how it is possible to reduce them through facade retrofitting solutions (external insulation, PCM, green wall, cool materials) in Mediterranean climate. The goal is to develop a set of climatic resilience indicators for opaque envelopes in order to consider resilience ability against climate change, both inside and outside of buildings.
Central recirculation zones and instability waves in internal swirling flows with an annular entry

The characteristics of the central recirculation zone and the induced instability waves of a swirling flow in a cylindrical chamber with a slip head end have been numerically investigated using the Galerkin finite element method. The effects of Reynolds number as well as swirl level adjusted by the injection angle were examined systematically. The results indicate that at a high swirl level the flow is characterized by an axisymmetric central recirculation zone (CRZ). The fluid in the CRZ takes on a solid-body rotation driven by the outer main flow through a free shear layer. Both the solid-body rotating central flow and the free shear layer provide the potential for the development of instability waves. When the injection angle increases beyond a critical value, the basic axisymmetric flow loses stability, and instability waves develop. In the range of Reynolds numbers considered in this study, three kinds of instability were identified: inertial waves in the central flow, and azimuthal and longitudinal ...
Evaluation and Treatment of Heat-Related Illnesses

The body's ability to regulate core temperature depends on both host (internal) and environmental (external) factors. Although athletes are commonly thought to be most at risk for heat illnesses, children and the elderly are particularly vulnerable. Heat cramps, which are caused by fluid and electrolyte imbalances, are treated with massage, and fluid and electrolyte replacement. Heat exhaustion occurs both as water- and sodium-depleted types, with associated symptoms such as malaise, vomiting, and confusion. Treatment involves taking the affected person to a cool environment and replacing fluids and electrolytes if needed. In more serious cases, intravenous hydration may be necessary, although monitoring of serum sodium levels is important to prevent cerebral edema. If not treated promptly, heat exhaustion may evolve into heatstroke, a deadly form of heat illness. Heatstroke occurs in classic and exertional forms and is present when the core body temperature exceeds 40 degrees C (104 degrees F). The patient may experience cardiac arrhythmias, rhabdomyolysis, serum chemistry abnormalities, disseminated intravascular coagulation, and death. Heatstroke is a medical emergency that should be treated immediately with temperature-lowering techniques such as immersion in an ice bath or evaporative cooling. Fluid resuscitation is important but should be closely monitored, and renal function may need to be protected with mannitol and diuretics. It is important to be vigilant for heat illnesses because they occur insidiously but progress rapidly.
Legal Decision Support: Exploring Big Data Analytics Approach to Modeling Pharma Patent Validity Cases

This exploratory research examines the potential for applying a big data analytic framework to the modeling and analysis of cases in pharmaceutical patent validity brought before the U.S. Court of Appeals of the Federal Circuit. We start with two specific goals: one, to identify the key issues or reasons the Court uses to makes validity decisions and, two, to attempt to predict outcomes for new cases. The ultimate goal is to support legal decision-making with automation. The legal domain is a challenging one to tackle. However, current advances in analytic technologies and models hold the promise of success. Our application of Hadoop MapReduce in conjunction with a number of algorithms, such as clustering, classification, word count, word co-occurrence, and row similarity, is encouraging, in that the results are robust enough to suggest these approaches have promise and are worth pursuing. By utilizing larger case data sets and sample sizes and by using deep machine learning models in text analytics, more breakthroughs can be achieved to provide decision support to the legal domain. From an economic standpoint, the potential for litigation cost reduction is another objective of our study. Synergies are obtained in applying lessons to the computational field and vice versa, leading to acceleration in our understanding.
Abstract 2799: New-generation glucose transporter inhibitors targeting non-small cell lung cancer and triple-negative breast cancer

Cancer is a top killer second only to cardiovascular diseases. Cellular metabolic reprogramming and altered energetics are key features of cancer. Opportunistic uptake of extracellular nutrients has recently been named as an emerging hallmark of cancer metabolism. Glucose is a key nutrient taken in by cancer cells to meet their high energy and biosynthesis needs. Drastic upregulation of glucose uptake and glycolytic activity, a phenomenon called the Warburg effect, is prevalent in most cancers, including non-small cell lung cancer (NSCLC) and triple-negative breast cancer (TNBC). Cancer cells overexpress specific glucose transporters (GLUTs), particularly GLUT1, on their membranes to transport glucose via facilitated diffusion. Considering the addiction of cancer cells for glucose and their sensitivity and vulnerability to changes in glucose supply, GLUTs, especially GLUT1, have been recognized as an attractive anticancer target. We previously reported the identification of first-generation lead GLUT1 inhibitor WZB117. WZB117 treatment of human NSCLC A549 cells resulted in inhibition of glucose uptake, glycolysis and induction of apoptosis and necrosis (1). In addition, WZB-117 reduced tumor growth by more than 70% in an A549 tumor mouse model (1). Through a structure activity relationship (SAR) study of WZB117, a second-generation lead, DRB18, has been identified. DRB-18 is much more stable and 5 to 10 times more potent than WZB117 in inhibiting growth and proliferation in more than 90% of the 60 different cancer cell lines in 9 major cancer types as revealed by NCI-60 screenings. The compound shows particularly higher potency against cell lines with more metastatic potential such as HOP92 (NSCLC) and MDA-MB-231 (TNBC) with IC50 values in high nM range. DRB-18 also demonstrates a favorable liver microsomal metabolic profile and a maximal tolerance dose (MTD). All these indicate that DRB-18 is a potential therapeutic candidate for treating NSCLC and TNBC. Reference: 1. Liu Y, Cao Y, Zhang W, et al. A small-molecule inhibitor of glucose transporter 1 downregulates glycolysis, induces cell-cycle arrest, and inhibits cancer cell growth in vitro and in vivo. Mol Cancer Ther 2012;11(8):1672-82. Citation Format: Pratik Shriwas, Yanrong Qian, Xuan Wang, Dennis Roberts, Stephen Bergmeier, Xiaozhuo Chen. New-generation glucose transporter inhibitors targeting non-small cell lung cancer and triple-negative breast cancer [abstract]. In: Proceedings of the American Association for Cancer Research Annual Meeting 2018; 2018 Apr 14-18; Chicago, IL. Philadelphia (PA): AACR; Cancer Res 2018;78(13 Suppl):Abstract nr 2799.
When culture is content: Applications for content-based instruction in the world language classroom:

Content-based instruction (CBI) is a pedagogical approach used in the second/other language classroom that commits to addressing both language- and content-learning objectives. Scholars have found that, particularly in the planning stages, teachers struggle with achieving that balance (Donato, 2016; Lyster, 2007). This study examines world language (WL) teachers’ planning for CBI via these research questions: (1) When experienced teachers from traditional WL classroom contexts design CBI unit plans, what do these plans reveal about the pathways they take towards CBI in a traditional WL settings? (2) What broader challenges and opportunities related to using CBI in the traditional WL context are revealed? The data sources in this qualitative lesson analysis study are 36 unit plans developed as the final project for a graduate-level course on CBI in one US institution. The three investigators examined the content–language dichotomy and the academic content-cultural content dichotomy in each lesson and ident...
Pilot Study of a Telehealth Delivery Method for Powerful Tools for Caregivers

Caregivers are at increased risk for physical and mental health problems. These risks may be mitigated through participation in an education-based wellness program, yet many caregivers face barrier...
Acellular pertussis vaccines : Towards an improved safety profile

The common adverse reactions associated with diphtheria, tetanus and pertussis (DTP) vaccination are less frequent and less severe with acellular DTP (DTaP) vaccines than with whole cell DTP (DTwP) vaccines. Five key parameters have been identified whose prevalence through the first 48 hours following vaccination accurately characterise the common manifestations of DTaP and DTwP reactogenicity: fever > 37.8 degrees C, moderate or severe fussiness, injection site redness, injection site swelling, and moderate or severe injection site pain. For every DTaP vaccine evaluated, significantly less reactogenicity has been observed in comparison to DTwP vaccines. Although there are differences among the acellular DTaP vaccines in the frequency and severity of some of the adverse reactions, these differences are minor in degree and nature. For both DTaP and DTwP vaccines, local reactions increase in prevalence and severity with successive inoculations. The safety of DTaP vaccines has now been established in infants receiving inoculations at 2,4 and 6 months of age and in other 2 and 3 inoculation sequences below 1 year of age, as well as in toddlers (1 to 3 year olds), preschool children (4 to 6 year olds) and in adults. The increased purity of DTaP vaccines should lead to a reduction in the rare, serious adverse reactions associated with pertussis vaccination.
Looking Back, and Ahead: A Call to Action for Increasing the Hospice and Palliative Medicine Specialty Pipeline

Thanks to the efforts of many individuals and organizations, the field of Hospice and Palliative Medicine (HPM) has undergone unprecedented growth over the last two decades. To meet the needs of seriously ill patients and families in inpatient, outpatient community setting in the future, the field of HPM must develop innovative strategies to expand the specialist workforce pipeline. With 148 programs participating in the National Residency Matching Program and 285 matched applicants in 2019, the specialty of HPM can barely replace those who are retiring or leaving the field. We call for a renewed and coordinated effort to increase the applicant pool for HPM fellowship positions, as well as greater access to specialist HPM training through expanded traditional fellowship programs and innovative specialist training pathways. Without such an expansion, our specialty will struggle to serve those patients and families who need us most.
Nurses' perceived emergency preparedness knowledge: An opportunity for improvement.

Objective: This study aimed to provide foundational data supporting the need for nursing education focused on emergency preparedness and response for nursing staff. Design: This study is a cross-sectional, quantitative, descriptive, correlational quality improvement study. Setting: The study location is a Midwest healthcare system comprised of 14 acute care facilities including pediatric and adult level I trauma centers, a burn center, and a fully dedicated pediatric hospital; five long-term care facilities; 230 ambulatory sites; 4,200 employed providers; and a health plan. Participants: A convenience sample of 5,172 currently employed nurses. Main Outcome Measure: The main outcome of this study is the documentation of overall familiarity with emergency preparedness and response knowledge among nursing staff. Logistic ordinal regression statistical analysis was completed to determine the significance of individual domains impacting the overall familiarity score. Results: Findings based on the results of the “overall familiarity with response activities related to a large-scale emergency incident” question documented most staff (78.45 percent) have little or no familiarity with their role in disaster response. Six domains or focused education areas were identified as having a statistically significant impact (p < 0.0001 –p = 0.0195) on the results of the overall familiarity question. Conclusions: These study results support the need for more education (academic and / or institutional) related to nursing emergency preparedness and response.
Field Theory of Primaries in W_N Minimal Models

For W_N minimal model CFT's at Large N, we formulate a nonlinear field theory of primary operators. A classification of single-trace operators is given first based on which an interacting field theory operating in Fock space is built. A hamiltonian is constructed with the property that it reproduces exactly the spectrum of conformal dimensions of all the primaries. This field theory is characterized by cubic (and quartic) interactions with G=1/N as an interaction parameter. It is seen that the 1/N nonlinear representation contains the interactions and structure known from Matrix-vector models.
Island Finder and Entropy Bound

Identifying an entanglement island requires exquisite control over the entropy of quantum fields, which is available only in toy models. Here we present a set of sufficient conditions that guarantee the existence of an island and place an upper bound on the entropy computed by the island rule. This is enough to derive the main features of the Page curve for an evaporating black hole in any spacetime dimension. Our argument makes use of Wall's maximin formulation and the quantum focusing conjecture. As a corollary, we derive a novel entropy bound.
The Effect of Body-Based Haptic Feedback on Player Experience During VR Gaming.

As the interest in virtual reality (VR) technology as a game console has rapidly grown over the past few years, many new technologies are also being developed to further enhance the VR gaming experience. One of these technologies is haptic feedback vests, which are beginning to hit the market with claims of elevating the player experience (PX). Since the use of haptic vests during gameplay is still in its early stages, their influence on the PX during VR gaming is understudied. Accordingly, the current study investigated the effect of providing body-based haptic feedback on players’ sense of presence and overall PX during VR gaming. Participants played a VR-based rhythm game both with and without a haptic feedback vest and provided self-reported ratings of their sense of presence and PX. Results revealed that there was no significant difference between playing with a haptic vest and without a haptic vest in terms of players’ sense of presence and PX during the gameplay. As a whole, these results indicate that providing body-based haptic feedback using a haptic vest may not always increase sense of presence and PX levels when playing a rhythm game in VR.
Genome edited B cells: a new frontier in immune cell therapies.

Cell therapies based on reprogrammed adaptive immune cells have great potential as "living drugs." As first demonstrated clinically for engineered chimeric antigen receptor (CAR) T cells, the ability of such cells to undergo clonal expansion in response to an antigen promotes both self-renewal and self-regulation in vivo. B cells also have the potential to be developed as immune cell therapies, but engineering their specificity and functionality is more challenging than for T cells. In part, this is due to the complexity of the immunoglobulin (Ig) locus, as well as the requirement for regulated expression of both cell surface B cell receptor and secreted antibody isoforms, in order to fully recapitulate the features of natural antibody production. Recent advances in genome editing are now allowing reprogramming of B cells by site-specific engineering of the Ig locus with preformed antibodies. In this review, we discuss the potential of engineered B cells as a cell therapy, the challenges involved in editing the Ig locus and the advances that are making this possible, and envision future directions for this emerging field of immune cell engineering.
Reliability of blood pressure responses used to define an exaggerated blood pressure response to exercise in young healthy adults.

Exaggerated blood pressure (BP) responses (EBPR) to exercise are prognostic of future cardiovascular risk. The primary objective of this study was to assess the test-retest reliability of BP responses used to categorize EBPR as absent or present. Twenty-seven healthy adults [21(2) years; 12 males] with resting BP < 130/80 mmHg completed a modified Bruce protocol treadmill exercise test on two visits separated by 6 (3) days. BP measurements were obtained during exercise using an automated auscultatory device. Submaximal and maximal systolic and diastolic BP, the change in diastolic BP from rest to maximal diastolic BP, and the change in systolic BP relative to the change in exercise intensity, quantified using the metabolic equivalent of task (SBP/MET-slope) were determined. Test-retest reliability of these BP responses was assessed using intraclass correlation coefficients (ICC) with a value ≥0.61 considered as substantial reliability. Submaximal diastolic BP demonstrated substantial reliability in the total group (ICC = 0.670; P ≤ 0.001). In males, submaximal systolic BP (ICC = 0.655, P < 0.01), submaximal diastolic BP (ICC = 0.699; P < 0.01) and maximal systolic BP (ICC = 0.794; P ≤ 0.001) demonstrated substantial reliability. All other BP responses were not reliable. Despite the prognostic value of EBPR, only three BP responses used to categorize EBPR demonstrated substantial test-retest reliability in healthy young males. In clinical practice, these preliminary findings would support the use of exercise BPs to identify young males with elevated cardiovascular risk, but additional research is needed to improve the clinical utility of exercise BPs and EBPR in females.
A Media Comparison of Consumer Perception of Feminine Care Product Advertising

The major finding of this study was the influence of media upon women 's perception of feminine care products advertisements. The media were ordered (from high to low) in terms of perceived appropriateness and tastefulness as follows: women 's magazines, general magazines, newspapers, radio and television. Respondents' perceptions were also affected by demographic and psychographic characteristics.
Singleness of surface and volume: Space–time non-symmetry of energy density

Abstract Space–time non-symmetry means that physical processes in the (+) direction are not the same as those in the (−) direction. Non-homogeneity and surface–volume interaction (SVI) are two aspects of the same effect that attributes to directional dependency. While the Einstein tensor and stress-energy tensor (SET) of space–time curvature are reminiscence of SVI, non-homogeneity were forsaken such that stress-energy became non-tensorial. The inconsistency definition of body-field energy and surface-traction force can be erased by considering SVI. No less emphasizes can be placed on the interchange of energy, mass and matter. Energy and mass trade-off can occur as a quotient via square of the “velocity” and product via square of the “momentum”. SVI was also recognized in the ‘80s as the missing link to explain crack growth in fatigue and non-equilibrium and non-homogeneous (NENH) problems in mechanics. Space–time non-symmetry (STNS) corresponds, respectively, to dissipated (past) and available (future) energy density. Paradigm-breaking called for higher order mathematical solutions to lock non-homogeneity and non-symmetricity into the experimental data that would otherwise be interpreted with oversimplified assumptions. The trade-offs of energy, mass, matter are made possible for a wide range of the speed of space, larger and smaller than the speed of light. The speed of light is no longer the pillar of particle physics. Corrections to ordinary data can thus be made without knowing the composition of the atomic structures, which may not explain nature in its entity. In the language of fracture mechanics, any available fatigue crack growth data can be corrected to include NENH and STNS for different scale ranges. The “energy density” fits into the space–time non-symmetry (STNS) scheme of non-zero volume/area. Physicists and engineers are no longer next door neighbors, but they live under the same roof. In a nut shell, science has identified the cause of space non-symmetry (SNS) and time non-symmetry (TNS), while technology has recognized the effect of NENH.
Toward Property Rights in Spectrum The Difficult Policy Choices Ahead

As described in Ronald Coase's seminal 1959 paper, property-like rights in electromagnetic spectrum and a secondary market for spectrum licenses will allocate spectrum to its highest and best uses, to the benefit of telecommunications consumers. However, defining rights to use spectrum is far more difficult than ordinarily suggested. More careful analysis is needed to determine what type of property regime will operate effectively to govern rights in spectrum. A number of questions must be answered for a transition to a property rights regime to be successful.
Validation of aberrometry‐based relative peripheral refraction measurements

College of Optometry, The Ohio State University, 338 West 10th Ave., Columbus, OH 43210, USAAbstractPurpose: To validate aberrometry-based relative peripheral refraction (RPR) measurements and toexamine RPR differences in the nasal and temporal horizontal visual ﬁeld.Methods: Thirty subjects underwent cycloplegia in the right eye. Ten measurements each weremade centrally, 30 nasally on the retina and 30 temporally on the retina using the CompleteOphthalmic Analysis System (COAS) aberrometer and the Grand Seiko WR-5100K autorefractor inrandom order. A 2-mm COAS analysis diameter was used to approximate the Grand Seikoautorefractor measurement beam diameter. Nasal and temporal RPR were calculated as thedifference between the average nasal or temporal spherical equivalent and the average centralspherical equivalent. Repeated measures ANOVAs were used to test for signiﬁcant differencesbetween the RPR readings of each instrument in each retinal location (nasal or temporal) and toexamine refractive error in each direction of gaze for both instruments.Results: Central spherical equivalent refractive error as measured by the Grand Seiko autorefractorranged from +0.63 D to )8.41 D (mean ± S.D. = )2.63 D ± 2.05 D). There were no signiﬁcantdifferences between the instruments for RPR measurements (p = 0.34). The nasal RPR wassigniﬁcantly more hyperopic than the temporal RPR (mean ± S.D. = +0.45 D ± 1.04 D, p = 0.02).Spherical equivalent refractive error in all directions of gaze was more myopic with the COAS thanwith the Grand Seiko autorefractor (mean ± S.D. = )0.41 D ± 0.61 D, p < 0.0001).Conclusions: RPR measurements with the COAS are feasible and equivalent to those made withthe Grand Seiko autorefractor. The COAS can be used to simultaneously collect RPR and peripheralaberration data. Nasal and temporal RPR measurements were signiﬁcantly different in our sample.Keywords: aberrometry-based refraction, autorefraction, ocular shape, relative peripheral refraction