cssi/SciSciGPT-SciSciNet huggingface dataset:
Epidermoid Metaplasia of the Cervix

44-year-old woman with a previous Papanicolaou test showing hyperkeratosis presented to her gynecologist with a 0.3-cm white lesion on the ectocervix, which was biopsied. On microscopic examination, the cervical specimen showed mild chronic inflammation. The cervical mucosa was covered by a keratinized squamous epithelium with mild acantholysis and a focal prominent granular cell layer (Figure 1; original magnification 340). The stroma showed a group of approximately 9 mature sebaceous glands (Figure 2; original magnification 3100) composed of sebaceous cells ringed by a layer of epithelial cells (Figure 3; original magnification 3400). As Groucho Marx once asked, ‘‘Who are you going to believe, me or your lyin’ eyes?’’ We wish for our readers to consider both. Even though sebaceous metaplasia is exceedingly rare, it was reported in the cervix as early as 1969. In fact, this observation led Bonilla-Musoles et al 1 to ask the opprobrious question, ‘‘Can the uterine cervix grow a moustache?’’ (Figure 1). The authors answered their rhetorical question with ‘‘evidently no.’’ They did concede that the cervical squamous epithelium can contain, with rarity, hair follicles, sebaceous glands, sweat glands, and other epidermoid structures, even pigmented nevi. This spectrum of changes has been named appropriately ‘‘epidermoid metaplasia.’’ 2,3 The tendency of cervical squamous epithelium to undergo a skinlike transformation is well known, and this change is especially seen in cases of uterine prolapse and conditions that expose the cervix to a constant source of irritation. Sebaceous gland metaplasia is most certainly a response to repeated traumatizing of the region. The most interesting and most perplexing question is how ectodermal glands can be derived from what has been thought to be endodermal and mesodermal derivatives. It is certainly possible, as some authors have suggested, that the ectocervix arises from the urogenital sinus. 2,3 The mullerian duct terminates at the mullerian tubercle, forming the early urogenital sinus. The mucosal lining of the urogenital sinus is replaced by squa
AN EMPIRICAL MULTIVARIATE LOG-NORMAL DISTRIBUTION REPRESENTING UNCERTAINTY OF BIOKINETIC PARAMETERS FOR 137CS

A simplified biokinetic model for 137 Cs has six parameters representing transfer of material to and from various compartments. Using a Bayesian analysis, the joint probability distribution of these six parameters is determined empirically for two cases with quite a lot of bioassay data. The distribution is found to be a multivariate log-normal. Correlations between different parameters are obtained. The method utilises a fairly large number of pre-determined forward biokinetic calculations, whose results are stored in interpolation tables. Four different methods to sample the multidimensional parameter space with a limited number of samples are investigated: random, stratified, Latin Hypercube sampling with a uniform distribution of parameters and importance sampling using a lognormal distribution that approximates the posterior distribution. The importance sampling method gives much smaller sampling uncertainty. No sampling method-dependent differences are perceptible for the uniform distribution methods.
Detection of Heterogeneity of Borrelia burgdorferi in Ixodes Ticks by Culture-Dependent and Culture-Independent Methods

Abilities to detect heterogeneity of ospC genotypes of the Lyme disease spirochete Borrelia burgdorferi in the tick vector by in vitro culture (IVC) and direct PCR (dPCR) were compared. IVC failed to detect one-third of the ospC genotypes detected by dPCR. Among IVC results, common ospC genotypes were overrepresented while occurrence of rare genotypes was underestimated.
Toward an Understanding of Suicide Risks in Young Hispanic Females

Hispanic adolescents in the United States have been virtually neglected in the literature on youth suicide. Among Hispanic youth, adolescent females constitute a subgroup at risk for depression and suicidal behavior. The author reviews extant literature on adolescent suicide, and discusses such psychosocial and cultural factors as socioeconomic disadvantage, traditional gender-role socialization, acculturation, cultural identity, and intergenerational conflict within the context of suicide attempts among adolescent Hispanic females. It is proposed that the interactive effects of these factors may contribute to suicide attempts among low income, first and second-generation Hispanic adolescent females. Language: en
CROSS-LINKED SMECTITES. IV. PREPARATION AND PROPERTIES OF HYDROXYALUMINUM- PILLARED Ce- AND La-MONTMORILLONITES AND FLUORINATED NH4+-MONTMORILLONITES

Reaction of hydroxy-A1 oligocations with Ce 3+- and La3+-exchanged montmorillonites, 1.25, 1.60, or 2.0 mmole A1/g smectite, yielded partially pillared hydroxy-A1 montmorillonite products containing a significant concentration of residual Ce 3+ or La 3+. After heat treatment at 250~ these products showed high surface areas (~340-500 mVg) and high basal X-ray powder diffraction spacings (18.0-18.6 /~). Calcination at 400~176 resulted in lower surface areas of ~200-450 m2/g and basal spacings of 16.3-18.3 A, the values showing a gradual decrease with a decrease in the A1/smectite weight ratio and/ or increase in the heat-treatment temperature. A major modification and improvement in the cross- linking procedure was achieved by fast aging (6-48 hr) of the hydroxy-A1 oligomeric solution at 95 ~ 100~ instead of conventional aging for 2-3 weeks at 25~ Fluorinated NH4+-montmorillonites, containing 0.4 to 2.1 wt. % F, were prepared by reaction ofNH4 § montmorillonite at 600C with 1.0 to 3.0 N aqueous solutions of NH4F. Interaction of the fluorinated montmorillonites with hydroxy-A1 oligocations, using a ratio of 2.0 mmole A1/g smectite, yielded a series of cross'linked fluorinated montmorillonites with basal spacings of 17.9-18.0/~ and surface areas of 180- 325 m2/g after heat treatment at 250~ Calcination at 400~176 resulted in lower d(001) (16.6-17.7 /~) and surface-area values (140-300 m2/g). Increase in the fluorine content caused gradual decrease in both values. Transmission electron microscopy of pillared Ce-montmorillonite showed a highly oriented network of well-separated, parallel unit layers with an interlayer distance, Ad(001), of 9-10 A. Calculated lateral (interpillar) distances were in good agreement with the pore-size distributions determined in independent adsorption studies.
Finding maximal submeshes in 2D mesh in the presence of failed nodes

In a parallel computer system with faulty processors, it is highly desirable to reconfigure the system by eliminating the faulty ones and thereby restore the system to some operational state. In the reconfiguration finding the maximum size fault-free subsystem is the main problem. We propose an efficient scheme for identifying maximum size fault-free submeshes in a faulty two-dimensional (2D) mesh system. For this, the relations between two submeshes in a 2D mesh have been defined. Then we take a two phase approach. In the first phase, an efficient algorithm for determining maximal faulty submeshes in a faulty mesh has been introduced. In the second phase, we have introduced a procedure to identify the maximal fault-free submeshes by splitting all faulty submeshes from a whole mesh. The time complexity of the proposed scheme is O(N/sub f//sup 2/) where N/sub f/ is the number of faulty processors in a 2D mesh. The proposed scheme can be utilized to the task allocation in 2D meshes in the presence of failed nodes.
Periocular extracranial cutaneous meningiomas in two dogs

Cutaneous meningiomas are rare tumors in human beings and animals. Two canine cases of cutaneous meningiomas affecting the eyelid are described in the current study: the first from a 5-week-old female Springer Spaniel dog with an 8 cm in diameter congenital mass expanding the left upper eyelid and medial canthus; the second from a 10-year-old female spayed Maltese-Poodle mix dog with 3 firm subcutaneous nodules affecting the right upper eyelid. All masses were removed surgically. Histologically, tumors were composed of spindle-to-epithelioid cells arranged in small lobules forming solid concentric whorls. Neoplastic cells were positive for vimentin and S100 and negative for pancytokeratin, glial fibrillar acid protein, and neurofilament. Transmission electron microscopy revealed meningothelial cells with convoluted interdigitating processes, desmosomes, and hemidesmosomes, and moderate numbers of cytoplasmic microfilaments. None of the cases presented a primary neuroaxial meningioma. The first case presents clinicopathological features consistent with human type I (congenital) cutaneous meningioma. The second case is consistent with a type II (acquired ectopic) tumor, and both are hypothesized to arise from ectopic arachnoid cells displaced during development.
Whither Go Pro-erectile Nerves of the Neurovascular Bundles?

In visual reconstructions, as contained in their remarkable figures, Alsaid and coworkers [1] used computer-aided anatomic ‘‘dissection’’ (CAAD) to follow the nerve fibers distally beyond the prostate apex, finding an anterior division destined for the corpora cavernosa and a posterior division entering the corpus spongiosum. Multiple sequential axial sectionswere obtained from the level of the seminal vesicles to the penis. They stained the sectionswith the silver stain for nerves (S-100), and then they used the computer to sum all the sections to reconstruct the course of the nerves three-dimensionally as they proceeded distally. With this method, identification of a split in nerve-fiber direction was possible. The points of termination beyond the apex of the prostate included an anterior group or division associated with the corpora cavernosa and dorsal sensory nerve of the penis and aposterior division entering the superior surface of the bulb of the penis, or corpus spongiosum. From a physiologic standpoint, just exactly how autonomic nerves of each neurovascular bundle (NVB) [2] heading distally interact and coordinate function, beyond the final result of producing an erection when stimulated, is not precisely clear. ‘‘Pro-erectile’’ nerves accompany other autonomic nerves within the NVBs that depart along the way to innervate seminal vesicles, vasa deferentia, bladder, rectum, and membranous urethra [3]. Some nerves at the apex of the prostate are parasympathetic; some are sympathetic [4]. What then becomes more complicated are concepts such as sympathetic nerves that are not adrenergic, as expected, but cholinergic with vasodilatory potential. To further complicate matters anteriorly at and beyond the penile hilum, there are proven visible neural connections with the dorsal sensory nerve of the penis where direct cavernous nerve penetration begins and proceeds distally [5]. The current study [1] confirms, during radical prostatectomy, the concept of anterior fascial and nerve preservation
Facilitating team decision-making through reimbursable contracting strategies11This paper is one of a selection of papers in this Special Issue on Construction Engineering and Management.

Efforts to break down decision-making silos in the architecture, engineering, and construction (AEC) industry have resulted in the evolution of integrated project delivery (IPD). IPD brings togethe...
beta -Amyloid peptide-induced apoptosis regulated by a novel protein containing a g protein activation module.

Degeneration of neurons in Alzheimer's disease is mediated by μ-amyloid peptide by diverse mechanisms, which include a putative apoptotic component stimulated by unidentified signaling events. This report describes a novel μ-amyloid peptide-binding protein (denoted BBP) containing a G protein-coupling module. BBP is one member of a family of three proteins containing this conserved structure. The BBP subtype bound human μ-amyloid peptidein vitro with high affinity and specificity. Expression of BBP in cell culture induced caspase-dependent vulnerability to μ-amyloid peptide toxicity. Expression of a signaling-deficient dominant negative BBP mutant suppressed sensitivity of human Ntera-2 neurons to μ-amyloid peptide mediated toxicity. These findings suggest that BBP is a target of neurotoxic μ-amyloid peptide and provide new insight into the molecular pathophysiology of Alzheimer's disease.
Women's Sexual Health: The Need for Feminist Analyses in Public Health in the Decade of Behavior:

Women’s sexual health is directly affected by women’s low status in society. This low status, and subsequent lack of sexual autonomy, not only increases risk for sexual health problems, it also decreases ability to obtain treatment and support when a sexual health concern arises. This has clearly been demonstrated in the HIV epidemic within the U.S. Earlier in the epidemic, women were simply ignored by public health research and practice. Once they could no longer be ignored, they were blamed and viewed as vectors. Current seroprevalence rates among men reveal that women are not significant vectors. In contrast, rates among women indicate that infection from men is the primary mechanism by which women are contracting HIV, and male-controlled sexual decision-making, male partner violence against women, and histories of sexual assault all contribute to increased HIV risk for women. Once infected, women are not given the support and resources they need as mothers and caretakers of HIV-positive partners and/or children. These findings are especially true for marginalized women such as women of color, poor women, women addicted to alcohol or drugs, and women who exchange sex for drugs or money. Findings from this review demonstrate the need for feminist approaches in understanding and addressing this issue in the Decade of Behavior. Such approaches must include an understanding of the needs of diverse women. An empowerment approach is needed to better contend with the sexual health needs of women; this must include the goal of ensuring women’s control of their own bodies.
Estrogen Receptor Residues Required for Stereospecific Ligand Recognition and Activation

The mouse estrogen receptor (mER) has been shown to exhibit stereospecific binding of certain stilbene estrogen agonists. The region of the mER involved in the stereochemical recognition of ligands was further defined using a stilbene isomer, Indenestrol B (IB). The IB compound has a chiral carbon bearing an ethyl substituent, and the wild type uterine mER has been shown to bind the enantiomers, IB-S and IB-R, with similar affinity. The wild type mER expressed in yeast exhibited a very minor preference for IB-S in transactivation (1.5-fold lower half-maximal dose than IB-R). The IB enantiomers could then be used to determine whether stereochemically distinct compounds with similar transcriptional activity utilize different amino acids in AF-2 for transactivation. Mutant mERs with glycine substitutions at Met521, His528, Met532, and Val537 were expressed in yeast and measured for IB-S- and IB-R-induced transactivation and ligand binding. The M532G mER showed a 124-fold and 50-fold reduction in transactivat...
Request redirection and data layout for network traffic balancing in cluster-based video-on-demand s

Cluster architecture is a cost-effective approach to building up scalable servers. For I/O-intensive videoon-demand (VoD) applications, network bandwidth is usually the primary bottleneck. In this paper, we propose a request redirection strategy to balance the network traffic in cluster-based VoD servers. The redirection strategy utilizes the servers' internal backbone bandwidth to equalize their external network traffic. Performance of redirection is related with data layouts based on replication. We implemented two replication methods and two placement methods for videos with different popularities. Furthermore, we evaluated redirection strategy with different data layouts. The simulation results verify the effectiveness of the redirection strategy and proposed data layout methods.
Compositionally controlled FePt nanoparticle materials

High temperature solution phase decomposition of Fe(CO)/sub 5/ and reduction of Pt(acac)/sub 2/ in the presence of stabilizers, oleic acid and oleyl amine, are employed to produce 4 nm diameter FePt nanoparticles. The Fe and Pt composition of the nanoparticle materials can be tuned by adjusting the molar ratio of Fe(CO)/sub 5/ to Pt(acac)/sub 2/, and the compositions ranging from Fe/sub 30/Pt/sub 70/ to Fe/sub 80/Pt/sub 20/ are obtained. The nanoparticle materials are easily dispersed into alkane solvent, facilitating their self-organization into nanoparticle superlattices. As synthesized FePt nanoparticles possess a disordered fcc structure and show superparamagnetic behavior. Thermal annealing induces a change of internal particle structure and thus of the magnetic properties of the particles. Composition dependent structure analysis shows that an annealed FePt nanoparticle assembly with a composition around Fe/sub 55/Pt/sub 45/ will lead to the highly ordered fct phase. This Fe/sub 55/Pt/sub 45/ nanoparticle assembly yields high coercivity, and will be a candidate for future ultra-high density magnetic recording media applications.
Carbohydrate Catabolism of Mima polymorpha I. Supplemental Energy from Glucose Added to a Growth Medium

Bell, Emily J. (University of Cincinnati, Cincinnati, Ohio), and Adrienne Marus. Carbohydrate catabolism of Mima polymorpha. I. Supplemental energy from glucose added to a growth medium. J. Bacteriol. 91:2223–2228. 1966.—Mima polymorpha, unable to grow in the presence of nonphosphorylated sugars as sole source of carbon and energy, grows rapidly and well in the presence of acetate, ethyl alcohol, short-chained fatty acids, and permeable intermediates of the tricarboxylic acid cycle. Chemical evidence indicates, however, a limited uptake of glucose. Further, glucose, although incapable of supporting growth as the sole source of carbon and energy, does increase both the rate of growth and the total cell crop when added as an ancillary nutrient to cells growing in a mineral salts medium which contains 0.03 m acetate as the carbon and energy source. A yield of energy from an abortive catabolism of glucose is hypothesized. In addition to the enhancement of growth rate and total cell crop, this hypothesis is supported by the facts that: (i) transport systems for the slightly permeable phosphorylated hexoses appear to be induced when glucose is incorporated into a medium capable of supporting growth and (ii) the rate of induction and the total activity of an inducible enzyme, isocitrate lyase E.C. 4.1.3.1., are markedly increased in the presence of supplemental glucose.
A C++ library for rapid development of efficient parallel dense linear algebra codes for multicore computers

To program parallel codes for task-based parallel execution, the full data dependency analysis between the tasks is required. However, finding all the flow, anti and output data dependencies is not an easy task for non-trial algorithms. In this paper, we present a simple C++ library that can analyze all the data dependencies between tasks and build the task graph automatically. Developing parallel dense linear algebra codes using our library and another two C++ libraries, Intel TBB and NICTA Armadillo, is simple and easy. The parallel codes developed by using our library are also efficient due to the efficient task scheduling of Intel TBB library and the fast matrix operations of NICTA Armadillo library.
Statistical-Mechanics-Inspired Optimization of Sensor Field Configuration for Detection of Mobile Targets

This paper presents a statistical-mechanics-inspired procedure for optimization of the sensor field configuration to detect mobile targets. The key idea is to capture the low-dimensional behavior of the sensor field configurations across the Pareto front in a multiobjective scenario for optimal sensor deployment, where the nondominated points are concentrated within a small region of the large-dimensional decision space. The sensor distribution is constructed using location-dependent energy-like functions and intensive temperature-like parameters in the sense of statistical mechanics. This low-dimensional representation is shown to permit rapid optimization of the sensor field distribution on a high-fidelity simulation test bed of distributed sensor networks.
Historical Channel Narrowing and Riparian Vegetation Expansion in the Medicine Lodge River Basin, Kansas, 1871–1983

Abstract Remeasurement of selected section line channel crossings from the 1871 first federal land survey of the Medicine Lodge River system in south-central Kansas revealed that channels have narrowed and riparian vegetation density has increased since white European settlement of the area in the early 1870s. Analysis of channel width data, daily precipitation data, aerial photography, tree cores extracted from riparian tree species and of testimony from long-term residents led to the development of a model suggesting that a series of wet years in the 1940s initiated the narrowing and allowed vegetation to stabilize mid-channel and bankside deposits. Precipitation during the 1940s was less seasonal than that during the 1930s, resulting in less variable stream discharge and lower peak discharges during the 1940s. Under this state of altered stream discharge, vegetation was able to become established on mid-channel and point bar deposits. Land use patterns, because they have not changed significantly in th...
Snake activity affects seasonal variation in nest predation risk for birds

Variation in predator behavior has been proposed, but not tested, as a mechanism producing seasonal declines in avian nest success. We test this hypothesis by documenting seasonal activity of Texas ratsnakes Elaphe obsoleta and nest failure of endangered black-capped vireos Vireo atricapilla and golden-cheeked warblers Dendroica chrysoparia on which the snakes prey. Nest survival analysis was based on 880 vireo and 228 warbler nests and 3,060 snake locations from 62 radio-tracked snakes. Although nest success varied with snake activity for both birds, specific patterns differed substantially. Vireo daily nest survival was negatively correlated with snake activity over the three-year study, despite substantial variation among years in weather, and the fact that these birds are almost certainly a minor prey species of the ratsnakes. Warblers exhibited less clear-cut seasonal variation in nest success, and the association between nest success and snake activity was less pronounced than for vireos. Increased activity at warmer temperatures explained some of the seasonal change in snake movements, although mating may have accounted for a mid-season peak in activity. These results indicate that variation in predator behavior can be associated with and potentially cause seasonal changes in nest success, but also that these relationships are species specific even within the same community and may depend on aspects of the nesting ecology of the prey such as nest site selection.
Charge-tunable indium gallium nitride quantum dots

III-Nitride quantum dots have emerged as a new chip-scale system for quantum information science, which combines electrical and optical interfaces on a semiconductor chip that is compatible with noncryogenic operating temperatures. Yet most work has been limited to optical excitations. To enable single-spin-based quantum optical and quantum information research, we demonstrate here quantized charging in optically active, site-controlled III-nitride quantum dots. Single-electron charging was confirmed by the voltage dependence of the energy, dipole moment, fine structures, and polarization properties of the exciton states in the quantum dots. The fundamental energy structures of the quantum dots were identified, including neutral and charged excitons, fine structures of excitons, and A and B excitons. The results lay the ground for coherent control of single charges in III-nitride quantum dots, opening a door to III-nitride-based spintronics and spin-qubit quantum information processing.
Acute Mountain Sickness Symptom Severity at the South Pole: The Influence of Self-Selected Prophylaxis with Acetazolamide.

Introduction Acetazolamide, a carbonic anhydrase inhibitor, remains the only FDA approved pharmaceutical prophylaxis for acute mountain sickness (AMS) though its effectiveness after rapid transport in real world conditions is less clear.
The Formation Mechanism of Fluorescent Metal Complexes at the LixNi0.5Mn1.5O4−δ/Carbonate Ester Electrolyte Interface

Electrochemical oxidation of carbonate esters at the LixNi0.5Mn1.5O4−δ/electrolyte interface results in Ni/Mn dissolution and surface film formation, which negatively affect the electrochemical performance of Li-ion batteries. Ex situ X-ray absorption (XRF/XANES), Raman, and fluorescence spectroscopy, along with imaging of LixNi0.5Mn1.5O4−δ positive and graphite negative electrodes from tested Li-ion batteries, reveal the formation of a variety of MnII/III and NiII complexes with β-diketonate ligands. These metal complexes, which are generated upon anodic oxidation of ethyl and diethyl carbonates at LixNi0.5Mn1.5O4−δ, form a surface film that partially dissolves in the electrolyte. The dissolved MnIII complexes are reduced to their MnII analogues, which are incorporated into the solid electrolyte interphase surface layer at the graphite negative electrode. This work elucidates possible reaction pathways and evaluates their implications for Li+ transport kinetics in Li-ion batteries.
Preliminary observations regarding the expression of collagen triple helix repeat-containing 1 is an independent prognostic factor for Wilms' tumor.

Abstract Purpose Overexpression of collagen triple helix-repeat containing 1 (CTHRC1) has been reported in many malignancies, where it plays an important role in tumorigenesis and progression. This study aimed to examine the clinical significance of CTHRC1 expression in patients with Wilms' tumor (WT). Methods The expression of CTHRC1, and its correlations with various clinicopathological parameters, was analyzed using immunohistochemistry in 42 WT tissues and 42 adjacent non-cancerous tissues. Samples from 8 patients with WT were examined using Western blotting and quantitative real-time polymerase chain reaction (qRT-PCR). Kaplan–Meier analysis and Cox proportional hazards regression models were used to investigate the correlations between CTHRC1 expression and the prognosis of patients with WT. Results Immunohistochemistry, Western blotting, and qRT-PCR revealed that the expression of CTHRC1 was significantly higher in WT tumors, compared to the expression in the adjacent non-cancerous tissues. Furthermore, high tumor expression of CTHRC1 was associated with tumor size, clinical stage, histopathological type, and vascular invasion/metastasis. Moreover, the proportions of expressing cells in the WT specimens was higher than the proportions in the matched adjacent non-cancerous tissues. Kaplan–Meier analysis revealed that patients with high CTHRC1 expression exhibited a shorter survival, compared to patients with low CTHRC1 expression. Univariate and multivariate analyses also revealed that CTHRC1 expression was an independent prognostic factor for overall survival. Conclusions Our preliminary results suggest that CTHRC1 is an independent prognostic factor, which may play an important role in tumorigenesis and progression, and may be a potential biomarker for WT.
Stages of Change of Smoking Cessation: Relationships With Other Health Behaviors

Health behaviors are often intercorrelated, suggesting that these behaviors may be manifestations of underlying attitudes toward health. Changes in these attitudes may cause simultaneous changes in several health behaviors. As individuals progress among the stages of change of one health behavior, such as smoking cessation, they may make changes in other health behaviors as well. This study evaluated the hypothesis that subjects in the later stages of change of smoking cessation would practice more healthful behaviors than subjects in the early stages of change. Subjects were 929 respondents in the California Behavioral Risk Factor Surveillance Study who were current smokers or had quit smoking within the past year. Subjects in the more advanced stages of smoking cessation showed more healthful levels of alcohol use and exercise than subjects in the earlier stages. These results suggest that people may make improvements in several health behaviors concurrently. If so, lifestyle-based health promotion programs may be able to take advantage of shifts in attitudes toward health behavior to modify several health behaviors simultaneously.
Utility of Magnetic Resonance Imaging in Acute Intracerebral Hemorrhage

The authors determine whether magnetic resonance imaging (MRI) during acute hospitalization for spontaneous intracerebral hemorrhage (ICH) provides new diagnostic information. ICD-9 codes were used to identify consecutive patients with spontaneous ICH at Hermann Hospital, Houston, Texas, between January 1995 and August, 1997. Two investigators employed rigorous criteria to determine whether the MRI findings led to a specific new diagnosis. Two hundred ninety-one patients met inclusion and exclusion criteria. Sixty-seven (23%) patients underwent brain MRI during the acute hospitalization. MRI provided a new diagnosis in 15 of these 67 patients (22%). Amyloid angiopathy and vascular malformation (four each) were the most frequently identified etiologies. The yield of MRI was low in basal ganglia and thalamic hemorrhage. Two of 23 (9%) patients with deep ICH and 13 of 44 (30%) patients with lobar and infratentorial hemorrhage had etiology determined by MRI. Timing of MRI did not affect yield.
Recent developments in pathogenesis, diagnosis and therapy of Barrett's esophagus.

The burden of illness from esophageal adenocarcinoma continues to rise in the Western world, and overall prognosis is poor. Given that Barrett’s esophagus (BE), a metaplastic change in the esophageal lining is a known cancer precursor, an opportunity to decrease disease development by screening and surveillance might exist. This review examines recent updates in the pathogenesis of BE and comprehensively discusses known risk factors. Diagnostic definitions and challenges are outlined, coupled with an in-depth review of management. Current challenges and potential solutions related to screening and surveillance are discussed. The effectiveness of currently available endoscopic treatment techniques, particularly with regards to recurrence following successful endotherapy and potential chemopreventative agents are also highlighted. The field of BE is rapidly evolving and improved understanding of pathophysiology, combined with emerging methods for screening and surveillance offer hope for future disease burden reduction.
Evaluating the clinical utility of the Validity-10 for detecting amplified symptom reporting for patients with mild traumatic brain injury and comorbid psychological health conditions.

ABSTRACTThe objective of this study was to compare the Validity-10 scale with the PAI Negative Impression Management Scale (PAI-NIM) for detecting exaggerated symptom reporting in active-duty military service members (SMs) admitted with unremitting mild TBI symptoms and comorbid psychological health conditions (mTBI/PH). Data were analyzed from 254 SMs who completed the Neurobehavioral Symptom Inventory (NSI) and Personality Assessment Inventory (PAI) as a part of a larger battery of self-report symptom scales upon admission to the intensive-outpatient TBI treatment program at a military medical center. Symptom exaggeration was operationalized using the PAI Negative Impression Management Scale (PAI-NIM). A PAI-NIM score of ≥73 was categorized as positive for symptom exaggeration (SVTpos), while a lower score was categorized as negative for symptom exaggeration (SVTneg). SMs in the SVTpos group (n = 34) had significantly higher scores (p ≤ .004) on the PAI clinical scales as well as on the NSI total score ...
Coronary Revascularization: How Can Model-Derived Probabilities Inform Clinical Judgment?

The study reported in this issue of JACC: Cardiovascular Interventions by Sotomi et al. [(1)][1] is the next step in addressing one of the principal challenges in coronary artery disease management: how to apply probability measures of risk and efficacy derived from population studies to identify
Reciprocity and rape: Blackness and the paradox of sexual violence

This essay expands Saidiya Hartman's unflinching paradigmatic analysis in Scenes of Subjection of the modes of historical continuity in which Black women are barred from reciprocity, recognition, a...
Restoring Balance for People with Cancer Through Integrative Oncology

Integrative Oncology incorporates conventional and western cancer treatment approaches with the best of ancient and traditional medicine including nutrition, supplements, Qigong, herbal medicine, mind-body practices, and more. This article offers a guiding conceptual paradigm from an integrative perspective based on the principles of balance and imbalance. An integrative approach is used to help improve quality of life, enhance lifestyle choices and mitigate symptoms and side effects from conventional treatments. By supporting the patient's mind, body and spirit throughout the cancer treatment journey, the primary care physician is in a key position to work with their patient's oncologist to provide supportive care and recommendations during cancer treatment.
Synthesis of secondary ethers derived from meadowfoam oil

Secondary ethers can be obtained from meadow-foam-derived delta lactones or 5-hydroxy fatty acids by using Lewis or Bronsted acid catalysts in good yield (70–90%). The conversion of δ-lactone or 5-hydroxy fatty acid to 5-ethers is performed under atmospheric pressure between 67 and 125°C with 0.5–6.4 mole equivalents of acid catalyst in the presence of 2–40 equivalents of alcohol and a reaction time of 1–140 h. Acid catalysts include mineral acids, such as perchloric and sulfuric; Lewis acids, such as boron trifluoride; and heterogeneous catalysts, such as clays and ion-exchange resins. Primary alcohols, such as methanol, butanol, decanol, and oleyl alcohol, or branched-chain alcohols, such as 2-ethylhexanol, can be used to make secondary ether fatty esters. The 5-ether fatty esters and the process for their formation have not been previously known and appear to be limited to structures where stabilized cations can be formed. The novel ethers were fully characterized by nuclear magnetic resonance and gas chromatography-mass spectrometry.
Anti-cancer effect of oncolytic adenovirus-armed shRNA targeting MYCN gene on doxorubicin-resistant neuroblastoma cells.

Chemotherapy is one of the few effective choices for patients with neuroblastoma. However, the development of muti-drug resistance (MDR) to chemotherapy is a major obstacle to the effective treatment of advanced or recurrent neuroblastoma. The muti-drug resistance-associated protein (MRP), which encodes a transmembrane glycoprotein, is a key regulator of MDR. The expression of MRP is a close correlation with MYCN oncogene in neuroblastoma. We have recently shown ZD55-shMYCN (oncolytic virus armed with shRNA against MYCN) can down-regulate MYCN to inhibit tumor cells proliferation and induce apoptosis in neuroblastoma. Here we further report ZD55-shMYCN re-sensitized doxorubicin-resistant cells to doxorubicin (as shown by reduced proliferation, increased apoptosis, and inhibited cell migration), and reduced the in vivo growth rate of neuroblastoma xenografts by down-regulation of MRP expression. Sequential therapy with doxorubicin did not affect the replication of ZD55-shMYCN in doxorubicin-resistant neuroblastoma cells, but decreased the expression of Bcl-2, Bcl-XL, MMP-1. Thus, this synergistic effect of ZD55-shMYCN in combination with doxorubicin provides a novel therapy strategy for doxorubicin-resistant neuroblastoma, and is a promising approach for further clinical development.
Burning the straits: indignation and hospitality in Ben Jelloun

Tahar Ben Jelloun’s Partir (2006) shines a spotlight upon a society plagued by poverty and corruption, where ‘burning’ refers both to the act of migrants setting sail across the sea, and to that of torching their identity documents to avoid repatriation. The intertwined fates of protagonists Azel and Miguel in their respective homelands of Morocco and Spain capture the dual nature of refuge and endangerment in the concept of hospitality, embodied within their national affiliations and in their fraught same-sex relationship. I follow the course of these voyagers into the unknown, arguing that Ben Jelloun upsets both political and sexual borders to reveal an omnipresent yearning for a better future, born from the flames of indignation. I situate Partir within the context of ongoing struggles around migration, reading it as a quest to achieve the cosmopolitan ideals of ethics and hospitality, but of a hospitality that is less focused on guest versus host and is aligned closer with conviviality.
Dry Dehydrogenation of Ethanol on Pt–Cu Single Atom Alloys

The non-oxidative dehydrogenation of ethanol to acetaldehyde and hydrogen is an industrially relevant chemical conversion. Although Cu-based catalysts show high reactivity toward oxidative ethanol dehydrogenation, the flat Cu(111) surface is rather inactive for ethanol dehydrogenation in the absence of water, surface oxygen or defects. Herein we show, using experimental and theoretical studies of model systems, that adding 1% Pt into the surface of Cu(111) to form dilute Pt–Cu single atom alloys (SAAs) increases the activity of Cu(111) for ethanol dehydrogenation sixfold. The mechanism of ethanol dehydrogenation was investigated at the molecular level using scanning tunneling microscopy, temperature programmed experiments and density functional theory calculations. Our results demonstrate that Pt–Cu SAAs are much more active than Cu(111) for converting ethanol to acetaldehyde and hydrogen in the absence of surface oxygen and water. Specifically, the O–H bond of ethanol is activated at Pt sites below 160 K, followed by ethoxy spillover to Cu sites which results in a significant increase of the ethoxy intermediate yield. The C–H bond of ethoxy is then activated at 310 K, and the final product, acetaldehyde, desorbs from Cu(111) in a reaction rate limited process. Finally, we show that the Cu model surfaces exhibit stability with respect to poisoning as well as 100% selectivity in the alcohol dehydrogenation to acetaldehyde and hydrogen.
Time Course of Flow-Mediated Dilation and Vascular Endothelial Growth Factor following Acute Stroke.

Objectives People after stroke demonstrate alterations in vascular endothelial function measured by flow-mediated dilation. Limited information is available in the literature on possible protective factors following stroke. The aims of the secondary analysis were (1) to characterize the time course of vascular endothelial function using flow-mediated dilation at 72 hours after stroke and 1 week later during inpatient stroke rehabilitation and (2) to determine whether flow-mediated dilation was related to vascular endothelial growth factor, brain-derived neurotrophic factor, or estimated prestroke peak oxygen uptake. Methods Flow-mediated dilation using Doppler ultrasound was assessed in bilateral brachial arteries at the defined time points. Flow-mediated dilation and blood draws occurred on the same day between 7:30 am and 9:00 am following an overnight fast. Enzyme-linked immunosorbent assay was used to quantify plasma vascular endothelial growth factor and brain-derived neurotrophic factor values. A nonexercise estimate was used to calculate prestroke peak oxygen uptake. Results We have shown that between-limb differences are evident within 72 hours after stroke and remain 1 week later during inpatient rehabilitation. Higher values for vascular endothelial growth factor were associated with increased flow-mediated dilation at both time points. Higher estimated prestroke peak oxygen uptake was related to flow-mediated dilation. Brain-derived neurotrophic factor was not related to any outcome measures. Conclusions Unique vascular adaptations start early after stroke in the stroke-affected limb and remain through inpatient stroke rehabilitation. Vascular endothelial growth factor and prestroke physical activity may have a protective role in vascular function following stroke. Future work should focus on mechanistic pathways for preservation of vascular health.
Crossing the Western Borders: Women of Son

While Turkish television shows have been quite popular in the Middle East, the Balkans, and South America, Turkish producers have been less successful in exporting content to the Western European and North American markets. After receiving moderate ratings in Turkey, Son (2012) was the first Turkish show to be sold to Western Europe when the Swedish public television stv2 purchased the rights to air it with subtitles. While the American adaptation, Runner , did not make it on air on ABC despite the pilot order, the Dutch and the Spanish adaptations were filmed in 2016 and 2017, respectively. Son ( The End ) remains the only success story among other attempts to introduce Turkish shows into these new markets. In this article, I argue that Son ’s two opposing female characters offer a reflexive discussion of Turkey’s identity, and that this allegorical representation, which anchors the story in the current geopolitical climate—mirroring Turkey’s role as an east-west bridge—enables the show to challenge the existing borders of travel for Turkish TV shows.
Storytelling and Spiritual Formation According to the Apostle Paul1

Storytelling is one of the favorite means the Apostle Paul frequently employs in his letters to enrich the spiritual formation of his converts. Philippians demonstrates this well. In this letter Pa...
A Case-Oriented Web-Based Curriculum in Geriatrics for Third-Year Medical Students

OBJECTIVES: This paper describes the development, implementation, and evaluation of a case-oriented, web-based curriculum in geriatric medicine for third-year medical students. DESIGN: Single cohort, pre/post trial. SETTING: University of Kansas School of Medicine, Kansas City, Kansas. PARTICIPANTS: Third-year medical students (n = 130). INTERVENTION: A web-based curriculum, offered during a clinical geriatrics clerkship, is composed of 13 case-oriented, web-based modules spanning key topics in geriatric medicine. Each module topic is also reviewed in a post-module, faculty-led discussion session. MEASUREMENTS: A pre-and post-rotation test of knowledge was completed. Student feedback about the curriculum was collected through web-based and written evaluation. MAIN RESULTS: Pre-and post-rotation comparison of examination scores demonstrated an average increase of 13 correct items on a 40-item exam. Seventy-five percent of students rated each module favorably at the time of completion (range 53-89%). Most modules (10/13) were rated as excellent or good after all modules had been completed. CONCLUSIONS: A case-oriented web-based curriculum in geriatrics was rated favorably by third-year medical students. Students' knowledge increased in key geriatric topics. Student feedback allows for continuous improvement of the curriculum. This model of curricular innovation may be useful for other institutions seeking to develop or enhance geriatric medicine content in the medical school curriculum.
Radio Spectrum Surveillance Station

The paper presents a general and functional description of a low-cost surveillance station designed as the first phase of NASA's program to develop a radio spectrum surveillance capability for deep space stations for identifying radio frequency interference sources. The station described has identified several particular interferences and is yielding spectral signature data which, after cataloging, will serve as a library for rapid identification of frequently observed interference. Findings from the use of the station are discussed.
Adaptive Dual Maximum Power Point Tracking Algorithm for PV DC-DC Conversion Stage

This paper proposes an adaptive dual maximum power point tracking (DMPPT) algorithm to maximize the energy harvested from a photovoltaic (PV) source. The proposed method tracks the maximum power from the PV source and the maximum efficiency of the DC-DC converter by perturbing both the PV voltage and the DC-DC converter switching frequency, and then observing the output power of the converter. The proposed method is very fast since it uses adaptive variable step sizes through the search loop. The proposed method employs various termination techniques that avoids, to a great extent, false termination of the search algorithm when local maximum points are detected. Moreover, the proposed method guarantees convergence and is very simple to implement. Derivation of the proposed technique followed by experimental verification are presented.
Community Identity and Shared Practice at Actuncan, Belize

Shared identities create deep historical ties to community spaces and can facilitate or constrict political expansion. This research examines the relationship between the ways in which families engaged local landscapes and developed shared identities at Actuncan, Belize, during the Terminal Classic period, a time when the city experienced population growth as surrounding centers declined. The nature and location of activity patterns in and around three residential groups allow inferences about shared practices and the expression of identities that those activities enabled and constrained. Importantly, this research includes investigations of both residential groups and architecturally free areas. It uses multiple methods to explore activities and to produce overlapping datasets, including excavation and analysis of macroartifacts, microartifacts, and soil chemical residues. The results suggest that Actuncan residents used not only the formal patio spaces of residential groups but also the interstitial spaces between them. Moreover, one residential group, Group 1, appears to have been a locus for distinct activities including sequential burials and, possibly, affiliative ritual practices connected to ancestral landscape use. Understanding relationships among residents is an important foundation for exploring broader political dynamics, including relationships between residents and rulers and how rulers created, legitimized, and maintained power and authority.
Atomic-resolution in-situ cooling study of oxygen vacancy ordering in La0.5Sr0.5CoO3−δ thin films

The presence and potential ordering of oxygen vacancies play an important role in determining the electronic, ionic, and thermal transport properties of many transition metal oxide materials. Controlling the concentration of oxygen vacancies, as well as the structures of ordered oxygen vacancy domains, has been the subject of many experimental and theoretical studies. In epitaxial thin films, the concentration of oxygen vacancies and the type of ordering depend on the structure of the substrate as well as the lattice mismatch between the thin films and the substrate. However, the role of temperature or structural phase transitions in either the substrate or the epitaxial thin films in the oxygen vacancy ordering has remained largely unexplored. In particular, atomic-resolution imaging and spectroscopy analysis of oxygen vacancy ordering in thin films at temperatures below 300 K have not yet been reported. Here, we use aberration-corrected scanning transmission electron microscopy combined with in-situ cooling experiments to characterize the atomic/electronic structures of oxygen-deficient La0.5Sr0.5CoO3−δ thin films grown on SrTiO3 across its antiferrodistortive phase transition at 105 K. We demonstrate that atomic-resolution imaging and electron energy-loss spectroscopy can be used to examine variations in the local density of states as a function of sample temperature.