cssi/SciSciGPT-SciSciNet huggingface dataset:
Lack of relationship between cigarette smoking and alcohol use with dysplasia grade in ocular surface squamous neoplasia.

Objective To evaluate smoking and alcohol use as risk factors for higher-grade dysplasia in a population of patients with histopathologically proven ocular surface squamous neoplasia. Materials and methods This is a retrospective chart review of data extracted from a database comprising demographic information and medical diagnosis information based on International Classification of Disease codes. Outcome measures were analyzed using the Wilcoxon two-sided test, a non-parametric t-test. Results Database review yielded 35 patients with ocular surface squamous neoplasia lesions proven by histopathologic analysis. The mean age was 64.51 years with SD 17.54 years. Patients were 28.57% female and 71.43% male. Nearly all patients were White (88.57%), and 5.71% were African American, 2.86% Hispanic, and 2.86% Other. There was no significant difference in dysplasia grade between smokers and non-smokers (P=0.7044), those who used alcohol vs did not use alcohol (P=0.2470), those who used tobacco and alcohol vs those who did not (P=0.5117), and those who used either tobacco or alcohol vs those who did not (P=0.8259). Conclusion No statistically significant relationship was found between high-grade dysplasia and cigarette smoking, alcohol use, or both cigarette smoking and alcohol use.
U.S. Mexican-origin adolescents' bicultural competence and mental health in context.

Objectives We examined the prospective association (from Mage = 15.84 to 17.38 years) between bicultural competence and mental health among U.S. Mexican-origin adolescents relative to multiple (a) developmental niches, (b) components of bicultural competence, and (c) indicators of mental health. Method Participants included 749 adolescents (49% female, 29.7% Mexico-born) recruited during late childhood and followed through late adolescence. We used latent profile analyses to identify adolescents' developmental niches based on sociocultural characteristics of the family, school, and neighborhood contexts and multiple-group structural equation modeling to examine whether these niches moderated the association between bicultural competence and mental health. Results We identified 5 distinct adolescents' developmental niches. We found no association between bicultural competence and internalizing symptoms across niches; bicultural facility predicted lower externalizing symptoms among adolescents developing in niches characterized by immigrant families and predominantly Latino schools and neighborhoods. Conclusions The diversity found among U.S. Mexican-origin adolescents' niches underscores the need to assess context broadly by including a range of settings. Studying multiple components of bicultural competence across numerous cultural domains may provide a better understanding of any mental health benefits of biculturalism. (PsycINFO Database Record (c) 2019 APA, all rights reserved).
Wage and Labor Supply: A Simple Model to Explain Some Empirical Findings

Research about labor supply with flexible hours generates some conflicted findings and raises debate — which model is better, intertemporal neoclassical or reference-dependent preferences? This paper provides the third solution — static neoclassical. Specifically, a simple model with Cobb-Douglas preferences, incorporating fixed cost and narrow bracketing of decisions, is provided. This model is able to explain the seemingly conflicted results in several renowned papers.
Early Stage Extranodal Follicular Lymphoma: Characteristics, Management, and Outcomes

Abstract Introduction Extranodal follicular lymphoma (E-FL) is a rare entity that has distinct characteristics and outcomes compared with nodal follicular lymphoma. Patients and Methods This cohort comprised 37 patients with stages I/II E-FL, diagnosed from 2003 to 2013. Outcomes included progression-free survival (PFS), and overall survival (OS). Survival outcomes were calculated using Kaplan–Meier methods. Results Median age was 60 years (range, 37-84 years). Disease was stage I in 29 (78.4%). The Follicular Lymphoma International Prognostic Index score was 0 to 1 in 31 (83.8%), 2 in 2 (5.4%), 3 in 1 (2.7%), and missing in 3 (8.1%). Sites of involvement included the gastrointestinal (GI) tract in 22 (59.5%), and non-GI sites in 15 (40.5%). Initial management consisted of chemotherapy (CHT) alone in 21 (56.8%), radiation therapy (RT) alone in 2 patients (5.4%), RT and rituximab in 1 (2.7%), CHT and RT in 7 (18.9%), and observation in 6 (16.2%). RT was to a median dose of 30.6 Gy (range, 23.4-44.0 Gy). At a median follow-up of 69 months (range, 8-157 months), 5-year PFS and OS were 70.4% and 94.4%, respectively. Although the 5-year PFS of those observed was worse than for those who received therapy (33.3% vs. 77.6%; P = .011), that did not translate into an OS difference. Patients who received RT as part of upfront management had a 100% local control (LC) rate and a trend toward improved 5-year PFS (90% vs. 62.2%; P = .067). Conclusion Early stage E-FL is an indolent disease and is associated with excellent OS. Treatment strategies should be individualized with RT prioritized when LC is a significant goal.
Morphological priming without semantic relationship in Hebrew spoken word recognition

We report on an auditory masked priming study designed to test the contributions of semantics and morphology to spoken word recognition in Hebrew. Thirty-one native Hebrew speakers judged the lexicality of Hebrew words that were primed by words which either share their root morpheme and a transparent semantic relationship with the target (e.g. poreʦ פורץ ‘burglar’ priming priʦa פריצה ‘burglary’) or share their root morpheme but lack a transparent semantic relationship with the target (e.g. mifraʦ מפרץ ‘gulf’ priming priʦa פריצה ‘burglary’). We found facilitatory priming by both types of morphological relatives, supporting that semantic overlap is not required for morphological priming in Hebrew spoken word recognition. Thus, our results extend the findings of Frost, Forster, & Deutsch’s (1997) Experiment 5 to the auditory modality, while avoiding confounds between root priming and Hebrew’s abjad orthography associated with the visual masked priming paradigm. Further, our results are inconsistent with models of word processing which treat morphological priming as reflecting form and semantic coactivation, and instead support an independent role for root morphology in Hebrew lexical processing.
The impact of surgery for metastatic pancreatic neuroendocrine tumor: a contemporary evaluation matching for chromogranin a level.

Abstract Background Studies supporting surgical management of metastatic pancreatic neuroendocrine tumor (PNET) are limited by selection bias. Chromogranin A (CgA) has been used as a biomarker for PNET and may reflect disease burden or biology. This study aimed to correlate CgA level with overall survival and to use it to match patients selected for different treatment approaches in an analysis of the impact of surgical management. Methods 1478 patients diagnosed with PNET in the National Cancer Database (2004–2014) were retrospectively identified, and logistic regression analyses were used to evaluate associations between the presence of metastatic disease and CgA level. After matching patients by CgA level and other factors predictive of surgical management, Kaplan–Meier survival analysis was performed. Results Median CgA level was significantly higher in metastatic versus localized PNET(169 ng/mL versus 66 ng/mL, p Discussion CgA level is predictive of the presence of distant metastatic disease and overall survival in PNET. When matched by CgA and other predictors of treatment approach, patients with metastatic PNET undergoing surgery have improved survival.
REMOTE SENSING AS A TECHNIQUE FOR SYNOPTIC INVENTORIES OF FISHERIES RELATED RESOURCES

Abstract Remote sensors on aircraft and satellites are being used effectively to map fisheries related physical and biological surface properties synoptically over large coastal and estuarine areas. Tidal wetlands are known to be important fisheries habitat. With color and color infrared photography one can delineate tidal wetland boundaries and plant types. Multispectral analysis techniques have been developed for estimating the emergent biomass and species composition. Multispectral scanners and laser fluorosensors are being tested for monitoring primary productivity of coastal surface waters and the outflow of plankton and detritus from marshes and estuaries. Satellites can locate some high probability areas for fish availability, such as nutrient rich upwelling areas off the coasts of Peru, western United States and Africa, primarily due to strong thermal and spectral gradients caused by colder upwelling water and its spectrally different nutrient/chlorophyll content. There also appears to be some correlation between coastal water properties such as water color, turbidity, chlorophyll concentration and the presence of fish. A review of the state of the art indicates that remote sensing can be used effectively to map plant species, productivity and fishery-related quality of wetland habitat. However, techniques being developed for determining surface water productivity, detritus/nutrient flow and fish availability require additional field testing to establish their reliability.
The cluster value problem in spaces of continuous functions.

AbstractWe study the cluster value problem for certain Banach algebras ofholomorphic functions deﬁned on the unit ball of a complex Banachspace X. The main results are for spaces of the form X= C(K). 1 Preliminaries. A cluster value problem for a complex Banach space Xis a weak version ofthe corona problem for the open unit ball Bof X, which is a long-standingopen problem in complex analysis when Xhas dimension at least 2. Insteadof studying when B is dense in the spectrum of a uniform algebra H ofbounded analytic functions on Bin the weak topology induced by H(coronaproblem), the cluster value problem investigates the following situation:Let B¯ ∗∗ be the closed unit ball of the bidual X ∗∗ , and let M H be the spec-trum (i.e. maximal ideal space) of a uniform algebra Hof norm continuousfunctions on Bwith H⊃ X ∗ .Then π: M H → B¯ ∗∗ ,given by π(τ) = τ| X ∗ for τ∈ M H ,is surjective (as a consequence of the results in Chapter 2 and5 of [10]). For each x ∗∗ ∈ B¯ ∗∗ ,M x ∗∗ (B) = π −1 (x
Population Demography, Ancestry, and the Biological Concept of Race

For more than 50 years, biological anthropology has argued against the use of the biological race concept. Despite such efforts, aspects of the concept remain in circulation within society and with...
POSITIVE INCENTIVES FOR POLLUTION CONTROL IN NORTH CAROLINA: A POLICY ANALYSIS

ABSTRACT North Carolina faces the challenge of promoting economic development while maintaining a high level of environmental quality. The “Pollution Prevention Pays” philosophy is that these goals are compatible. However, economic and political incentives are necessary to implement this approach at the state level. The major question is: how can profit-seeking entrepreneurship be harnessed to reduce pollution? After examining a variety of regulatory and economic responses to pollution, this paper developes a new approach based on investments in change-in-production process technologies. The major policy innovation proposed is a “negative pollution tax”. If pollution prevention pays, the role of such a tax must be to make it pay faster, and with more certainty. In addition to clearly targeted levels of pollutants in a series of categories, the tax proposal rewards firms innovating technologies which reduce pollution levels below the targeted level. Further information can be provided by state agencies and universities to assist in the adoption of these technologies. Information sharing is also promoted by tax credits to firms engaged in “waste exchanges”. Together, these incentives promote more rapid adoption of new technologies, as well as climate of increased certainty and higher quality information. The result can be compatibility of investment and growth and continuation of North Carolina's high quality of life.
The language of subjective alcohol effects: Do young adults vary in their feelings of intoxication?

Among young adults, subjective feelings of alcohol's effects often guide risky decision making. The majority of studies measuring subjective effects have used singular indices ("How drunk do you feel?") which limits our understanding of young adults' full range of subjective states and their individual differences in subjective effects language. Toward a more in-depth understanding of the heterogeneity among alcohol users based on their subjective experiences of alcohol's effects, we identified latent classes of individuals based on their self-generated language describing feelings after drinking and compared these classes across demographic and drinking characteristics. Participants (N = 323, 54% women, 68% White, Ages 18-25 years) were recruited using Amazon's Mechanical Turk (MTurk). Participants listed words they would use to describe how they feel after drinking low, moderate, and heavy amounts of alcohol. Four latent classes of young adults emerged: "happy drinkers" (31%) primarily reported feeling "happy" when drinking; "relaxed drinkers" (24%) reported feeling happy, relaxed, and buzzed; "buzzed drinkers" (18%) reported feeling buzzed and dizzy; and "multiexperience drinkers" (27%) reported feeling buzzed, tipsy, drunk, and wasted. Relaxed drinkers indicated heavier alcohol use and buzzed drinkers reported lower drinking frequency. Classes did not differ by demographic characteristics. Young adult alcohol users can be distinguished based on the language they use to describe their feelings of intoxication. To continue to advance our understanding of subjective effects, it is necessary to take into account the full range of language used and how this language differs by young adult drinking behavior. (PsycInfo Database Record (c) 2020 APA, all rights reserved).
Using Invasional Meltdown Theory to Understand Patterns of Invasive Richness and Abundance in Forests of the Northeastern USA

Invasional meltdown hypothesizes that invasive species facilitate the establishment of subsequent invaders, with cascading consequences for ecosystem structure and function, including the extirpation of native species. However, meltdown has rarely been tested empirically with large regional data sets, leading to somewhat equivocal support. Recently, the USDA Forest Service initiated sampling of nonnative plants within a subset of their Forest Inventory and Analysis (FIA) plots, presenting an ideal dataset to evaluate meltdown and its consequences across large geographies. We used FIA data from 963 plots across 11 northeastern states to test the predictions of invasional meltdown and to examine the mechanism through which invasion impacts native tree seedling richness. Remeasured plots showed a significant increase in the number and cover of invasive species over time. We provide support for invasional meltdown, finding a pattern of accelerating invasive species richness over 4–5 y in plots with higher initial invasive species richness. Also, we found that plots with higher levels of invasive abundance corresponded to decreased native tree species richness at one point in time and that the magnitude of the relationship appeared to be stronger after 4–5 y. Our results suggest that evidence of invasional meltdown is more clearly evident when examining invasive plant species richness over time; further, invader abundance (measured as cover) is a better predictor of impacts than invader richness, which supports growing evidence that invasive abundance is an important driver of ecological impact.
An uncertainty-aware framework for reliable disaster damage assessment via crowdsourcing

Abstract Accurate and timely estimation of incurred damages is a critical component of effective disaster management, usually performed by trained inspectors and experts. The limitations in resources and workforce can hinder the timely acquisition of critical information and make the process costly. Crowdsourcing and participatory disaster damage assessment have emerged as a possible solution to address this challenge. However, such approaches generally suffer from a lack of reliability. This research improves the effectiveness of crowdsourcing in post-disaster damage assessment by enhancing the content and reliability of information gathered through public participation. The paper presents a novel framework for quantification and reduction of uncertainty in the outcome of participatory damage assessment. First, to reduce the complexity and subjectivity, the classification of overall damage state is decomposed into more straightforward microtasks in the form of a questionnaire survey. A decision rule is implemented to infer the damage state of buildings from the participant responses. Second, an information-theoretic model based on a maximum a posteriori probability estimation is presented for obtaining an accurate probabilistic description of the inferred damage states while quantifying and accounting for the reliability of the citizen participants as well as the relative ambiguity of images. A pilot study is presented by involving 70 non-expert citizen participants to assess the post-disaster imagery of 60 buildings collected following Hurricane Harvey. A comparison of the outcome with the available expert labels shows relatively high accuracy. The proposed model also outperforms the common majority-vote approach, especially as the number of unreliable participants increases.
County-Level Variation in Hepatitis C Virus Mortality and Trends in the United States, 2005-2017

BACKGROUND AND AIMS Since 2013, the national hepatitis C virus (HCV) death rate has steadily declined, but this decline has not been quantified or described on a local level. APPROACH AND RESULTS We estimated county-level HCV death rates and assessed trends in HCV mortality from 2005 to 2013 and from 2013 to 2017. We used mortality data from the National Vital Statistics System and used a Bayesian multivariate space-time conditional autoregressive model to estimate age-standardized HCV death rates from 2005 through 2017 for 3,115 U.S. counties. Additionally, we estimated county-level, age-standardized rates for persons <40 and 40+ years of age. We used log-linear regression models to estimate the average annual percent change in HCV mortality during periods of interest and compared county-level trends with national trends. Nationally, the age-adjusted HCV death rate peaked in 2013 at 5.20 HCV deaths per 100,000 persons (95% credible interval [CI], 5.12, 5.26) before decreasing to 4.34 per 100,000 persons (95% CI, 4.28, 4.41) in 2017 (average annual percent change = -4.69; 95% CI, -5.01, -4.33). County-level rates revealed heterogeneity in HCV mortality (2017 median rate = 3.6; interdecile range, 2.19, 6.77), with the highest rates being concentrated in the West, Southwest, Appalachia, and northern Florida. Between 2013 and 2017, HCV mortality decreased in 80.0% (n = 2,274) of all U.S. counties with a reliable trend estimate, with 25.8% (n = 803) of all counties experiencing a decrease larger than the national decline. CONCLUSIONS Although many counties have experienced a shift in HCV mortality trends since 2013, the magnitude and composition of that shift have varied by place. These data provide a better understanding of geographic differences in HCV mortality and can be used by local jurisdictions to evaluate HCV mortality in their areas relative to surrounding areas and the nation.
Short-Term Retention of Patient and Caregiver Ventricular Assist Device Self-Care Skills After Simulation-Based Mastery Learning

Abstract Background We developed a simulation-based mastery learning (SBML) curriculum that boosted self-care skills for patients with a ventricular assist device (VAD). In this study, we evaluated short-term skills retention. Method We assessed skill retention among patients and caregivers who participated in VAD self-care SBML at a tertiary care center. We compared discharge skills tests (immediately after completing SBML) with 1- and 3-month follow-up tests to assess skill retention. Results Fifteen patients and 15 caregivers completed discharge and follow-up testing. Skills were largely retained at 1 and 3 months. Conclusions SBML results in short-term retention of VAD self-care skills.
MC-100093, a Novel β-Lactam Glutamate Transporter-1 Enhancer Devoid of Antimicrobial Properties, Attenuates Cocaine Relapse in Rats.

Cocaine use disorder currently lacks Food and Drug Administration–approved treatments. In rodents, the glutamate transporter-1 (GLT-1) is downregulated in the nucleus accumbens after cocaine self-administration, and increasing the expression and function of GLT-1 reduces the reinstatement of cocaine seeking. The β-lactam antibiotic ceftriaxone upregulates GLT-1 and attenuates cue- and cocaine-induced cocaine seeking without affecting motivation for natural rewards. Although ceftriaxone shows promise for treating cocaine use disorder, it possesses characteristics that limit successful translation from bench to bedside, including poor brain penetration, a lack of oral bioavailability, and a risk of bacterial resistance when used chronically. Thus, we aimed to develop novel molecules that retained the GLT-1–enhancing effects of ceftriaxone but displayed superior drug-like properties. Here, we describe a new monocyclic β-lactam, MC-100093, as a potent upregulator of GLT-1 that is orally bioavailable and devoid of antimicrobial properties. MC-100093 was synthesized and tested in vitro and in vivo to determine physiochemical, pharmacokinetic, and pharmacodynamic properties. Next, adult male rats underwent cocaine self-administration and extinction training. During extinction training, rats received one of four doses of MC-100093 for 6–8 days prior to a single cue-primed reinstatement test. Separate cohorts of rats were used to assess nucleus accumbens GLT-1 expression and MC-100093 effects on sucrose self-administration. We found that 50 mg/kg MC-100093 attenuated cue-primed reinstatement of cocaine seeking while upregulating GLT-1 expression in the nucleus accumbens core. This dose did not produce sedation, nor did it decrease sucrose consumption or body weight. Thus, MC-100093 represents a potential treatment to reduce cocaine relapse. SIGNIFICANCE STATEMENT Increasing GLT-1 activity reliably reduces drug-seeking across classes of drugs; however, existing GLT1-enhancers have side effects and lack oral bioavailability. To address this issue, novel GLT-1 enhancers were synthesized, and the compound with the most favorable pharmacokinetic and pharmacodynamic properties, MC-100093, was selected for further testing. MC-100093 attenuated cued cocaine seeking without reducing food seeking or locomotion and upregulated GLT-1 expression in the nucleus accumbens.
Genetically Modified Organisms

Tremendous advances in the life sciences have paved the way for the development of a powerful array of new biotechnologies. As a consequence, the promise of the genetic manipulation of food animals for social benefit is now becoming a reality. This paper is intended to provide the bovine practitioner with a brief introduction to biotechnology, genomics, bioinformatics, gene mapping, cloning, genetically modified organisms and transgenic animals. Relevant recent advances are discussed in light of their potential impact on the beef, dairy and veterinary industries. The paper concludes with discussions of the distribution of regulatory responsibilities and the challenges facing the widespread adoption of these technologies in food production.
A Nonheme Mononuclear {FeNO}7 Complex that Produces N2O in the Absence of an Exogenous Reductant

A new nonheme iron(II) complex, FeII (Me3 TACN)((OSiPh2 )2 O) (1), is reported. Reaction of 1 with NO(g) gives a stable mononitrosyl complex Fe(NO)(Me3 TACN)((OSiPh2 )2 O) (2), which was characterized by Mossbauer (δ=0.52 mm s-1 , |ΔEQ |=0.80 mm s-1 ), EPR (S=3/2), resonance Raman (RR) and Fe K-edge X-ray absorption spectroscopies. The data show that 2 is an {FeNO}7 complex with an S=3/2 spin ground state. The RR spectrum (λexc =458 nm) of 2 combined with isotopic labeling (15 N, 18 O) reveals ν(N-O)=1680 cm-1 , which is highly activated, and is a nearly identical match to that seen for the reactive mononitrosyl intermediate in the nonheme iron enzyme FDPnor (ν(NO)=1681 cm-1 ). Complex 2 reacts rapidly with H2 O in THF to produce the N-N coupled product N2 O, providing the first example of a mononuclear nonheme iron complex that is capable of converting NO to N2 O in the absence of an exogenous reductant.
Options for the Catastrophic Failed Reverse Shoulder Prosthetic

Since its invention by Dr. Paul Gramont, the reverse shoulder replacement has been a miracle for both the rotator cuff tear arthropathy patient with pseudoparalysis and the patient with a failed rotator cuff surgery. Results are generally quite good in restoring function and alleviating pain. This has led to an expansion of indications, which has unfortunately resulted in an increase in failures that require revision surgery. In this chapter, we will preview the more common causes of failure and discuss possible approaches to restore function.
LOW-COST SHORELINE PROTECTION

As the public interest in low-cost, self-installed solutions to shoreline erosion continues to grow, the involvement of private enterprise in developing solutions intensifies. Now that low-cost devices are identified as a salable commodity as goods or services, the number of inventors, creative engineers, agronomists, and foresighted planners producing potential designs are rapidly growing. Over two hundred devices, both proven and untested devices, have been cataloged as a part of the National Shoreline Erosion Demonstration Program. This program calls for the Corps of Engineers to plan, establish, and conduct for a period of five years a shoreline erosion control development and demonstration program including physical and vegetative devices.
Abstract 3899: ROCK inhibitor as a differentiation-inducing agent to target glioma stem cells

Only 3% of patients diagnosed each year with Glioblastoma Multiforme (GBM) survive longer than 5 years, making GBM one of the most lethal forms of human cancer. It has been proposed that GBMs are driven by a rare subset of tumor cells referred to as cancer stem cells (CSCs), which have the ability to resist conventional radio- and chemotherapy and initiate disease recurrence. Thus, the development of novel and effective therapeutic strategies targeting CSCs is required and should significantly improve the dismal prognosis for patients with GBM. A possible viable strategy to effectively target glioma stem cells (GSCs) is the use of bone morphogenetic proteins (BMPs) as differentiation inducers. Our results suggest that Rho-associated protein kinase (ROCK) could work as a pharmacological negative regulator of BMPs. Our preliminary data indicate that: i) Fasudil, a ROCK1 inhibitor, induces BMP2 and BMP4 expression both in vitro and in vivo in different human-derived glioma xenograft models; ii) Fasudil-induced BMPs can increase the expression of differentiation markers and decrease stemness in these glioma models; iii) temozolomide, a chemotherapeutic agent, converts glioma cells to a GSC phenotype, while Fasudil blocks this interconversion; iv) co-administration of Fasudil with temozolomide inhibits the invasive characteristics of GBM in an orthotropic glioma xenograft model; and v) the analysis of BMP expression in human-derived GBM samples from the Repository of Molecular Brain Neoplasia Database (REMBRABDT) reveals that patients with higher BMP2 expression survived four times longer than those with low or intermediate BMP2 expression (p Citation Format: Brenda Auffinger, Alex L. Tobias, Yu Han, Maciej S. Lesniak, Atique U. Ahmed. ROCK inhibitor as a differentiation-inducing agent to target glioma stem cells. [abstract]. In: Proceedings of the 105th Annual Meeting of the American Association for Cancer Research; 2014 Apr 5-9; San Diego, CA. Philadelphia (PA): AACR; Cancer Res 2014;74(19 Suppl):Abstract nr 3899. doi:10.1158/1538-7445.AM2014-3899
The effects of ad-context congruency on responses to advertising in blogs: Exploring the role of issue involvement

This study examines the effect of ad–context congruency and the moderating role of issue involvement on consumers’ responses to banner ads on blogs. Results indicate that a banner ad that is thematically congruent with the blog’s context generates more favourable responses than an ad that is not congruent with the context. However, issue involvement moderates the effect of congruency. When a banner ad was placed in a congruent context, individuals who were highly involved with the issue discussed in the blog responded more positively to the ad. However, when a banner ad was placed in an incongruent context, individuals who were less involved with the issue responded more favourably to the ad. Findings suggest that ad–context congruency is especially important when targeting audiences who feel the issue is very relevant to them. In contrast, ad–context incongruency is better perceived by individuals who are less involved with the issue. We explain these findings using the tenets of contextual priming vs co...
J-Kernel: a capability-based operating system for Java

Safe language technology can be used for protection within a single address space. This protection is enforced by the language's type system, which ensures that references to objects cannot be forged. A safe language alone, however, lacks many features taken for granted in more traditional operating systems, such as rights revocation, thread protection, resource management, and support for domain termination. This paper describes the J-Kernel, a portable Java-based protection system that addresses these issues. J-Kernel protection domains can communicate through revocable capabilities, but are prevented from directly sharing unrevocable object references. A number of micro-benchmaxks characterize the costs of language-based protection, and an extensible web and telephony server based on the J-Kernel demonstrates the use of language-based protection in a large application.
Animals as Domesticates: A World View through History

(2014). Animals as Domesticates: A World View through History. Anthrozoos: Vol. 27, No. 3, pp. 475-476.
Analysis of Regression Methods for Solar Activity Forecasting

A key input to the utility of any solar-weather-climate relationship is the ability to forecast solar activity. The regression method of McNish and Lincoln has received considerable application in forecasting the sunspot cycle behavior. This paper provides a sensitivity analysis of the behavior of such regression methods relative to aspects such as cycle minimum, time into cycle, composition of historical data base, and unnormalized versus normalized solar cycle data. Comparative solar cycle forecasts for several past cycles are given relative to these aspects of the input data. Implications for the current cycle, No. 21, are likewise given.
Phytoestrogens induce differential estrogen receptor alpha- or Beta-mediated responses in transfected breast cancer cells.

Increased intake of phytoestrogens may be associated with a lower risk of cancer in the breast and several other sites, although there is controversy surrounding this activity. One of the mechanisms proposed to explain the activity of phytoestrogens is their ability to bind and activate human estrogen receptor a (ERα) and human estrogen receptor β (ERβ). Nine phytoestrogens were tested for their ability to transactivate ERα or ERβ at a range of doses. Mammary adenocarcinoma (MCF-7) cells were co-transfected with either ERα or ERβ, and an estrogen-response element was linked to a luciferase reporter gene. Dose-dependent responses were compared with the endogenous ligand 17β-estradiol. Purified genistein, daidzein, apigenin, and coumestrol showed differential and robust transactivation of ERα- and ERβ-induced transcription, with an up to 100-fold stronger activation of ERβ. Equol, naringenin, and kaempferol were weaker agonists. When activity was evaluated against a background of 0.5 nM 17β-estradiol, the a...
Born Fast, Die Young?: A Study of the User's Social Network Site Continuance

How to keep users has become the most desirable knowledge to social network site SNS managers. In the current study, the author proposes a user's SNS continuance model by incorporating the information system continuance model and the impression management theory. The author finds that a user's actualization of the hoped for possible self and perceived informativeness of an SNS are two critical factors that can significantly positively influence the user's perceived usefulness of the SNS, perceived enjoyment on the Web site, and his or her SNS continuance intention. The author suggests that these findings provide several practical implications to SNS management and development.
Ethnic group differences in racial identity attitudes, perceived discrimination and mental health outcomes in African American, Black Caribbean and Latino Caribbean college students

The increasing presence of Black Caribbean and Latino Caribbean college students in higher education settings requires helping professionals to more clearly understand their unique racial identity developmental needs and experiences with discrimination in order to fortify their academic endeavors and contribute to their success. A series of 3 × 2 ANOVAs and MANOVAS were conducted to examine ethnic group differences in racial identity attitudes, perceived racial discrimination and mental health outcomes in 159 African American, Black Caribbean and Latino Caribbean college students in an urban college setting in the Northeast USA. Results indicated that dissonance and immersion racial identity status attitudes were significantly linked to perceived racial discrimination and depression for all participants. Findings also showed a main interaction effect between ethnicity and racial identity conformity attitudes and mental health outcomes with high conformity linked to increased perceived stress for Latino Ca...
An AC electroosmotic processor for biomolecules

This paper describes an AC electrokinetic processor for biomedical analysis systems. The processor exploits AC electroosmosis for concentrating bioparticles, such as cells and molecules. Particle image velocimetry (PIV) is used to characterize the AC electroosmotic flow. A combination of the AC electroosmotic flow and other electrokinetic forces allows collection and concentration of the bioparticles. By optimizing the operating parameters, we have successfully demonstrated concentration of various biological objects, such as E. coli bacteria, /spl lambda/ phage DNA, and single-strand DNA fragments as small as 20 bases.
Enumeration schemes for permutations avoiding barred patterns

We give the first comprehensive collection of enumeration results for permutations that avoid barred patterns of length $\leq 4$. We then use the method of prefix enumeration schemes to find recurrences counting permutations that avoid a barred pattern of length $>4$ or a set of barred patterns.
Effects of ethanol and nitrous oxide, alone and in combination, on mood, psychomotor performance and pain reports in healthy volunteers

Ethanol and nitrous oxide (N2O) are sometimes used in combination by recreational drug users. The subjective effects of this drug combination have not been examined, and was the basis for the present study. The effects of both drugs were examined alone and in combination. Dependent measures included mood, cognitive/psychomotor performance, and pain reports. Volunteers (N = 11) first consumed a drink containing ethanol (0, 0.25, or 0.5 g/kg), waited for 15 min, and then inhaled 100% oxygen (placebo) or 30% N2O in oxygen for 35 min. Thirty minutes into the inhalation, subjects immersed their non-dominant forearm in icy water for 3 min. Ethanol increased ratings of 'feel drug effect' and 'drunk'. N2O affected several mood ratings, impaired cognitive/psychomotor performance, and reduced pain reports. There were several instances of ethanol potentiating the effects of N2O, and instances in which the drug combination produced effects that neither drug alone did. Ethanol did not potentiate the analgesic effects of N2O. Overall, the data obtained in the study did not convincingly demonstrate that the drug combination of N2O and ethanol had a greater abuse liability than did N2O alone, at the doses that were tested.
Brittle fracture: Variation of fracture toughness with constraint and crack curving under mode I conditions

The effect of constraint on brittle fracture of solids under predominantly elastic deformation and mode I loading conditions is studied. Using different cracked specimen geometry, the variation of constraint is achieved in this work. Fracture tests of polymethyl methacrylate were performed using single edge notch, compact tension and double cantilever beam specimens to cover a bread range of constraint. The test data demonstrate that the apparent fracture toughness of the material varies with the specimen geometry or the constraint level. Theory is developed using the critical stress (strain) as the fracture criterion to show that this variation can be interpreted using the critical stress intensity factorKCand a second parameterT orA3,whereT andA3are the amplitudes of the second and the third term in the Williams series solution, respectively. The implication of this constraint effect to the ASTM fracture toughness value, crack tip opening displacement fracture criterion and energy release rateGCis discussed. Using the same critical stress (strain) as the fracture criterion, the theory further predicts crack curving or instability under mode I loading conditions. Experimental data are presented and compared with the theory.
O(/spl radic/log n) approximation to SPARSEST CUT in O/spl tilde/(n/sup 2/) time

We show how to compute O(/spl radic/log n)-approximations to SPARSEST CUT and BALANCED SEPARATOR problems in O/spl tilde/(n/sup 2/) time, thus improving upon the recent algorithm of Arora, Rao and Vazirani (2004). Their algorithm uses semidefinite programming and required O/spl tilde/(n/sup 4.5/) time. Our algorithm relies on efficiently finding expander flows in the graph and does not solve semidefinite programs. The existence of expander flows was also established by Arora, Rao, and Vazirani.
The link of Kirchhoff migration and demigration to Kirchhoff and Born modeling

The Kirchhoff approximation provides a representation of seismic data as a summation of imaged data along isochron surfaces (demigration). The asymptotic inversion of this representation provides a migration as a summation of seismic data along diffraction surfaces. We replace Born inversion techniques with Kirchhoff inversion techniques and further show the link between the Kirchhoff and Born representations after the Born linearized reflection coefficient is replaced by the Kirchhoff reflection coefficient.
Optimal allocation of stock levels and stochastic customer demands to a capacitated resource

This paper considers a new class of stochastic resource allocation problems that requires simultaneously determining the customers that a capacitated resource must serve and the stock levels of multiple items that may be used in meeting these customers’ demands. Our model considers a reward (revenue) for serving each assigned customer, a variable cost for allocating each item to the resource, and a shortage cost for each unit of unsatisfied customer demand in a single-period context. The model maximizes the expected profit resulting from the assignment of customers and items to the resource while obeying the resource capacity constraint. We provide an exact solution method for this mixed integer nonlinear optimization problem using a Generalized Benders Decomposition approach. This decomposition approach uses Lagrangian relaxation to solve a constrained multi-item newsvendor subproblem and uses CPLEX to solve a mixed-integer linear master problem. We generate Benders cuts for the master problem by obtaining a series of subgradients of the subproblem’s convex objective function. In addition, we present a family of heuristic solution approaches and compare our methods with several MINLP (Mixed-Integer Nonlinear Programming) commercial solvers in order to benchmark their efficiency and quality.
Modernism: Cure or disease?

Abstract Donald Kuspit's The Cult of the Avant‐Garde Artist traces the therapeutic mission of modern art through its rise and decline into postmodern decadence. The problems Kuspit rightly finds in such artists as Warhol and Koons, however, are endemic to modernism itself: its diagnosis of bourgeois society as sick and in need of cure is fundamentally unsound. The modernist cure is, moreover, worse than the purported disease. What modernists call kitsch is, in many cases, a healthy, tragic view of life. And while modernist metaphysics teaches the need for unmediated sensory experience and the inauthenticity of reproduction and representation, contemporary science shows these ideas to be without foundation.
PARAXIAL RAY TRACING IN 3D INHOMOGENEOUS, ANISOTROPIC MEDIA1

Many investigations of the propagation elastic waves within the earth require a technique for producing synthetic seismograms which is capable of modelling 3D propagation effects. Ray methods are an excellent option for these problems, because they can be made fully 3D and allow a relatively quick and flexible computation of synthetic seismograms. However, the two point problem of finding the ray which connects exactly a specific source and receiver, may still be difficult and time consuming. Therefore, application of the paraxial method, which allows extrapolation of the information on a given ray to nearby receiver locations, is very valuable. With this approach, great savings in computation time and significant simplification of computer codes are possible. We investigate the application of the paraxial ray method to two problems in which the effects of 3D seismic wave propagation are important. The first is a model of a reef structure. In this case, we consider synthetic seismograms for a VSP experimental configuration. When the SV source and well are located along the axis of the reef, only 2D propagation effects are observed. If the source-receiver plane is located to the side of the reef, however, the 3D shape of the reef causes significant amplitudes to be predicted for shear-wave arrivals on the transverse component of the synthetic seismograms. The second example is a ID, layered earth model, but it includes two layers which are azimuthally anisotropic due to the presence of aligned, vertical fractures. This anisotropy leads to 3D raypaths. Synthetic seismographs are presented for a cross-hole geometry both for an equivalent isotropic model and for the direction parallel to the fractures and at an angle of 45° to the fractures in the anisotropic case. These synthetics show that the differences between the isotropic case and the case for source and receivers aligned with the plane of the fractures are small and subtle. On the other hand, the predictions for the direction at 45° to the cracks show shear-wave splitting and significant transverse component signal. These results have important implications for both modelling and for applications such as tomography. It is clear that for some of the cases considered, a 2D algorithm will lead to errors in interpretation of data. In addition, ray-based tomographic techniques will have great difficulty in obtaining a well-defined 2D planar image when the signals are propagating in regions outside the image plane.
Pencil-based renewable biosensor for label-free electrochemical detection of DNA hybridization

Abstract The characteristics and advantages of a renewable DNA hybridization biosensor based on a pencil electrode transducer are described. The surface of this biosensor can be renewed rapidly, by a simple mechanical extrusion, hence, obviating the need for an additional regeneration step. The sensor, thus, responds rapidly to the ‘switching’ between target and non-complementary oligonucleotide solutions, with the use of fresh surfaces erasing memory effects. The intrinsic redox activity of the target DNA is employed for detecting the duplex formation. Relevant experimental parameters were examined and optimized. The selectivity of the new device was demonstrated for the detection of a single-point mutation in the BRCA1 breast cancer gene. Such low-cost, renewable graphite transducers provide an attractive alternative to conventional carbon electrodes used for transducing DNA hybridization. By eliminating the needs for a regeneration step and an external indicator, the device offers a greatly simplified operation and holds promise for decentralized genetic testing.
Noncoronary and coronary atherothrombotic plaque imaging and monitoring of therapy by MRI

In the future, the use of imaging methods to quantify the progression and regression of atherosclerosis could play a strong role in the management of patients. High-resolution, noninvasive MRI may provide exhaustive 3-D anatomic information about the lumen and the vessel wall. Furthermore, MRI has the ability to characterize plaque composition and microanatomy and therefore to identify lesions vulnerable to rupture or erosion. The high resolution of MRI and the development of sophisticated contrast agents offer the promise of molecular in vivo molecular imaging of the plaque. This may aid early intervention (e.g., lipid lowering drug regiments) in both primary and secondary treatment of vascular disease in all arterial beds.
The effect of work-hardening and pile-up on nanoindentation measurements

Nanoindentation is performed on the cross-section of copper samples subjected to surface mechanical attrition treatment (SMAT). The cross-section of the SMAT samples provides a unique microstructure with varying amounts of work-hardening depending on the distance from the SMAT surface. Results show that for a given indentation load the pile-up height decreases and the indentation depth increases as the distance from the SMAT surface increases, both following a power law relationship. Based on image analysis of the indented surface this increase in the pile-up height and decrease in indentation depth is attributed to the localization of plastic strain due to the increased resistance to dislocation motion in the work-hardened region. For a given amount of work-hardening (in terms of distance from SMAT surface), the indentation depth increased with the indentation load obeying a power law relationship with the exponent ranging from 0.58 to 0.68. However, the pile-up height increased linearly with the load, with the rate (slope) increasing with the amount of work-hardening. The observed linear increase in pile-up height with indentation load would naturally introduce an indentation size effect (ISE) if the hardness is corrected for the pile-up. Interestingly, this ISE associated with pile-up increased with an increase in indentation depth, in contradiction to the ISE associated with strain gradient. Deviation of the hardness values corrected for pile-up from the bulk behavior due to surface effect is highlighted and a method to obtain a bulk-equivalent hardness quantity representing the bulk behavior is proposed.