cssi/SciSciGPT-SciSciNet huggingface dataset:
It takes two to tango

For cancer, the age of combination therapy has dawned, and synergy is the name of the game. Tumor antigen–specific antibodies have paved the therapeutic path, but the promise of joining antibodies with immune-stimulating cytokines has failed to show clinical improvement over antibodies alone. Zhu et al . hypothesized that unsuccessful partnerships between the cytokine interleukin (IL)-2 and therapeutic antibodies have resulted from the cytokine’s rapid degradation in vivo. Here, the authors enhance IL-2 bioavailability by fusing it with a heterologous protein fragment, finally forcing the cytokine’s antitumor power to manifest. The team fused mutated variants of a mouse IgG2a Fc region to mouse IL-2. Once-weekly administration of the Fc–IL-2 fusion protein and a melanoma-specific anti–TYRP-1 antibody (TA-99) tapped into the therapies’ synergistic effects—they halted tumor growth and enhanced survival while avoiding much of toxic effects of daily IL-2 administration. Enhanced survival was also observed in other solid-tumor mouse models when distinct antitumor antibodies were dosed with the IL-2 fusion protein, thus demonstrating the general nature of the therapeutic approach. Mechanistic studies revealed a complex interplay between immune cell recruitment and cytokine signaling in the treated tumors. Last, when the Fc–IL-2+TA99 combination was combined with adoptive T cell therapy, the authors observed a long-term survival response that lasted at least 3 months after treatment without relapse. The durable response was likely to be caused by Fc–IL-2–driven continued expansion of the infused T cells in the tumor. Such designer therapeutics highlight how bioengineers can leverage their own synergy of biological knowledge and cutting-edge technology to transform medicine. Yet the powerful immunotherapy did not come without consequence. The authors observed treatment-associated splenomegaly as well as elevation in serum levels of liver enzymes and inflammatory cytokines. Also, a tumor-lysis syndrome might be even more pronounced if these combinations were applied to fully developed tumors, as would be the case in clinical settings. Humanizing the fusion protein and exploring dose-limiting efficacy and toxicology studies in full-grown tumors might balance the risk profile of Fc–IL-2, recruiting a new player to the cancer arena. And this one’s got moves. E. F. Zhu et al ., Synergistic innate and adaptive immune response to combination immunotherapy with anti-tumor antigen antibodies and extended serum half-life IL-2. Cancer Cell 27 , 489–501 (2015). [[Abstract]][1] [1]: http://dx.doi.org/10.1016/j.ccell.2015.03.004
Social Media ACTion: SOLO Data Description

This technical report summarizes the demographics and Socially Observed Linked Opinion (SOLO) dataset, which came out of the Social Media ACTion study that took place at Carnegie Mellon during the summer of 2015. 124 individuals rated 4,320 social media posts and 1,680 news clips along the three dimensions used in Affect Control Theory. The report includes a description of the data, the training materials provided, and the consent form used for this study.
B0 -orientation dependent magnetic susceptibility-induced white matter contrast in the human brainstem at 11.7T.

Purpose To investigate B0-field-orientation dependent white matter contrast in the human brainstem based on R2* and frequency difference (Δf) mapping from gradient echo (GRE) imaging at 11.7T. Methods Multi-echo GRE data were acquired from two fixed human brainstem specimens at multiple orientations with respect to the static B0 field. The B0-orientation dependent modulation curves of R2* and Δf measurements between short and long echo time regimes were used to reconstruct maps of three-dimensional (3D) white matter orientation vectors. The results were compared with maps from diffusion MRI, susceptibility tensor imaging, and histological staining of the same specimens. Results R2* and Δf maps demonstrated distinct and significant contrast modulation between the corticospinal tract (CST) and transverse pontine fibers (TPF) dependent on B0 orientation. Interleaved fiber orientations of the CST and TPF could be sensitively resolved based on field-orientation-dependent fitting of the R2* and Δf measurements. The fitted 3D orientation vector maps and peak-to-peak amplitude of R2* and Δf modulation exhibited close correspondence to primary eigenvector and anisotropy maps derived from diffusion MRI. The amplitude of B0-orientation dependent R2* modulation was significantly (P < 0.005) higher in the CST compared with TPF, while fractional anisotropies were comparable. Conclusion The findings of this study demonstrate the potential of B0-orientation dependent susceptibility-induced R2* and Δf contrasts to probe tract-specific orientation and microstructure in white matter. Magn Reson Med 75:2455–2463, 2016. © 2016 Wiley Periodicals, Inc.
FRACTURE IMAGING IN THE UPPER KAMA POTASH MINE USING 3-D GPR DATA

Fracture detection and delineation is very important for salt mines operation because fracturing significantly increases the probability of failure of supporting pillars and overlaying water protective beds. Results of forward modeling studies confirmed the feasibility of georadar with a 400 MHz antenna to reliably detect the millimetric scale fracture. 3-D GPR data were acquired in the potash mine near the city of Solikamsk, Russia to evaluate the effectiveness of imaging technology to detect and delineate the fractures in heterogeneous salt rock. Continuous common-offset data were obtained at seven parallel profiles across the fracture exposed in the wall of a mine pillar. The pillar was 4.5 m thick and comprised of interbedded layers of salt rock and clay. The open millimetric scale subvertical fracture crosscuts the pillar at angle of 25°. Data were collected using commercial OKO georadar system (Logis, Russia) with a 400 MHz shielded antenna. ReflexW and OpendTect software were used for processing and interpretation of the 2-D radargrams and combined 3-D data set. The 3-D migration allowed generating a true image of subsurface structures and creating a spatial model of fractures. Using the image of known fracture as interpretation template, fracture having no surface evidence was detected.
Latency characteristics of an EPO and LLT mutant of pseudorabies virus.

7. Le Gall-Recule G, Jestin V: 1994, Biochemical and genomic 10. Renault L: 1980, Mycosis and mycotoxins des vollailes. Rec characterization of muscovy duck parvovirus. Arch Virol 139: Med Vet 156:641-649. 121-131. 11. Schrincke E: 1991, Faisan de chasse–elevage et maladies, pp. 8. Muller RD, Carlson CW, Semeniuk G, et al.: 1970, The re195-408. Editions du Point Veterinaire, Maison-Alfort, France. sponse of chicks, ducklings, goslings, pheasants and poults to 12. Swarbrick O: 1973, Inclusion body hepatitis in pheasants. Vet graded levels of aflatoxins. Poult Sci 49:1346-1350. Rec 93:209. 9. Poli A, Nigro M, Gallazzi D, et al.: 1991, Acute hepatosis in European brown hare (Lepus europaeus) in Italy. J Wildl Dis 27:621-629.
The Organization of the Communist Camp

The Communist camp is composed of twelve states: the Soviet Union, China, Poland, Czechoslovakia, East Germany, Rumania, Hungary, Bulgaria, North Korea, North Vietnam, Albania, Mongolia. Jointly, the Communist-ruled states account for about 38 per cent of the world's population, 24.2 per cent of the world's area, and approximately one-third of the world's industrial output. During Stalin's lifetime the Communist bloc operated essentially through a relatively simple subordination of the various units to the dictator's will, generally expressed by indirect methods of police and party control. This somewhat informal organization reflected in part the old dictator's specific political style; in part it was a function of the relatively immature stage of the bloc's development. As a result, the “maturation” of the bloc coincided with the difficult post-Stalin period of transition within the USSR and was marked by major upheavals and tensions. By 1958-1959, however, the crisis had subsided, and a new and more complex image of the bloc became apparent. While the Soviet Union continued to exercise leadership, acknowledged at the November 1957 conference of the Communist parties and buttressed by Soviet international and technological prestige, the camp had developed more elaborate mechanisms and processes of cohesion that also contributed to its unity. Some of them dated back to the Stalinist days, but were now infused with new vitality. Others emerged during the post-Stalin phase.
Detection of embB gene related with isoniazid-resistance in Mycobacterium tuberculosis

Objective:To observe the mutations of KatG gene in isoniazid-resistant Mycobacterium tuberculosis(MTB) strains from Lishui city.Methods:Analyzing mutations of KatG gene in 48 clinical isolates of MTB by PCR-DNA.Results:INH susceptibility testing were obtained 12 isolates of drug-resistant MTB,INH-sensitive MTB 36,drug-resistant strains accounted for 25.00%(12/48).No insertion or deletion mutation was found in these specimens 77.08%(37/48) rclinical isolates had katG mutation in S315 and R463 code region 9 isolates had AGC to ACC mutations at codon S315;37 isolates had CGG to CTG mutations at codon R463;9 isolates had mutations both at codon S315 and R463,there are 3 isolates no mutations occurred.Conclusion:INH resistance in some MTB isolates were due to mutations on KatG genes was frequently observed usually situated in codon S315 in Lishui city,with the sensitivity test match rate was 100%.Nonsense mutation in KatG gene R463/L.INH resistance was related with spot mutation of KatG gene in MTB,but other mechanisms may need be explored.
Long-acting gonadotropin hormone-releasing hormone analogused to treat uteri

Because the size of leiomyomata uteri often decreases significantly after menpause, the authors elected to employ a long-acting gonadotropin hormone-releasing hormone analog (GnRH-a) (imbzl-D-His 6 -Pro 9 -Net-GnRH) to create a state of pseudomenopause in six patients with leiomyomata uteri diagnosed on the basis of pelvic examination and confirmed by pelvic ultrasonography. Patients received daily, subcutaneous injections of GnRH-a (4 μ g × kg −1 × 24 hour −1 ) for 6 months. Uterine size (13.8±4 weeks [mean±standard deviation (SD), n=6]) was determined by pelvic examination and uterine volume (533.9±394 ml [mean±SD, n=6]) was determined by pelvic ultrasonography before medical therapy was begun. They observed a decrease in uterine size by pelvic examination within 4 weeks ofthe initiation of therapy, and all patients experienced a decrease in uterine size (9.5±4 weeks [mean±SD, n=6]) ( P −1 throughout the period of therapy. All six patients have discontinued therapy. There has been no increase in uterine size in these patients for a period from 3 to 7 months. The authors conclude that the administration of a long-acting GnRH-a appears to be a practical method for reducing the size of uterine leiomyomata and may serve a useful role either as a primary means of therapy or as an adjunct to surgical myomectomy, especially in patients with exceedingly large myomas who wish to conserve reproductive capability.
Thoracic Nerve Root Entrapment by Intrathecal Catheter Coiling: Case Report and Review of the Literature.

Background Intrathecal catheter placement has long-term therapeutic benefits in the management of chronic, intractable pain. Despite the diverse clinical applicability and rising prevalence of implantable drug delivery systems in pain medicine, the spectrum of complications associated with intrathecal catheterization remains largely understudied and underreported in the literature. Objective To report a case of thoracic nerve root entrapment resulting from intrathecal catheter migration. Study design Case report. Setting Inpatient hospital service. Results/ case report A 60-year-old man status post implanted intrathecal (IT) catheter for intractable low back pain secondary to failed back surgery syndrome returned to the operating room for removal of IT pump trial catheter after experiencing relapse of preoperative pain and pump occlusion. Initial attempt at ambulatory removal of the catheter was aborted after the patient reported acute onset of lower extremity radiculopathic pain during the extraction. Noncontrast computed tomography (CT) subsequently revealed that the catheter had ascended and coiled around the T10 nerve root. The patient was taken back to the operating room for removal of the catheter under fluoroscopic guidance, with possible laminectomy for direct visualization. Removal was ultimately achieved with slow continuous tension, with complete resolution of the patient's new radicular symptoms. Limitations This report describes a single case report. Conclusion This case demonstrates that any existing loops in the intrathecal catheter during initial implantation should be immediately re-addressed, as they can precipitate nerve root entrapment and irritation. Reduction of the loop or extrication of the catheter should be attempted under continuous fluoroscopic guidance to prevent further neurosurgical morbidity.
Argatroban for Anticoagulation during Cardiopulmonary Bypass.

The incidence of heparin-induced thrombocytopenia (HIT) with the use of heparin (H) might be higher in cardiac patient than other populations. Sometimes, these patients require surgery with the use of extracorporeal circulation (heart-lung machine or oxygenator). Anticoagulation during this surgery is essential, and almost always done with heparin. Knowledge in this setting about alternative anticoagulants, bleeding complications, monitoring problems, and drug elimination is limited. Here, we describe our experience with the direct thrombin inhibitor argatroban for anticoagulation during cardiac surgery. CASE REPORT: A 48-year-old male presented with weakness. He was found to have new onset atrial fibrillation with rapid ventricular rate and congestive heart failure. Echocardiography and blood cultures revealed staphylococcus endocarditis affecting the mitral valve and he received antibiotics. The patient started heparin on admission, and developed thrombocytopenia six days later. HIT antibody was positive, heparin was stopped and argatroban was initiated. Platelet count normalized. After two weeks, he required the insertion of an intra-aortic balloon pump and mitral valve replacement for severe mitral regurgitation. On the day of surgery, a baseline celite activated clotting time (ACT) was 253 seconds (s). A loading dose of argatroban was given (10 mcg/kg) followed by continuous infusion of 3.0–6.0 mcg/kg/min. The ACT ranged from 423–755 s during the surgery. The patient received platelets and plasma products for adequate hemostasis of the surgical site, but had increase bleeding during the first post-operative day. Argatroban was held for 36 hours after surgery. During this period, his activated partial thromboplastin time (aPTT) ranged between 25.4 – 33.8 s. After that, argatroban was re-started and the aPTT kept between 48–55 s. On post-operative day (POD) 3, doppler studies revealed a venous thrombus in the right upper extremity. On POD 6 the patient started warfarin and continued to have a full recovery. DISCUSSION: This case exemplifies the successful use of argatroban for anticoagulation during emergent cardiac surgery where heparin was contraindicated. The ACT monitoring was adequate and there were no unexpected complications. However, our patient suffered a venous thrombosis in the early post-operative period. In addition to the surgical complications, patients with HIT are at high risk for developing both venous and arterial thrombosis. Our case highlights the need for early anticoagulation with argatroban following surgery. We speculate that the delay in starting argatroban after surgery might have predisposed the patient to have a deep vein thrombosis. Yet, it is difficult to determine when to start anticoagulation in a highly thrombophilic patient who has significant post-operative bleed. CONCLUSION: Argatroban, with ACT monitoring, can be safely used for emergent cardiac surgery in patients with HIT. The timing of post-operative anticoagulation may pose a challenge for the clinician.
Yellow Aphid Control, 2014

Efficacy of several insecticides was evaluated for BMA and YPA control. The two species of yellow aphids (YAs) are difficult to separate in the field; therefore, both species were pooled and collectively referred to as YAs. This study was conducted in a commercial pecan orchard in Pecos County, TX. A single pecan tree constituted an experimental unit. Experimental units were arranged in an RCBD with seven treatments replicated four …
Synthetic aperture imaging with thinned linear sensor arrays for medical ultrasound

In this paper, we exploit motion for improving the ultrasound (US) imaging performance of thinned sensor array systems. Thinned arrays provide reduced system cost and allows for the reduction of bulky channel cables. However, thinned array systems suffer from poor array processing performance from the lack of channels available to the system when compared to a Uniform Linear Array (ULA). To overcome these deficiencies we propose to use motion to augment the transmit/receive events such that a general thinned array can be made to perform statistically equivalently to a ULA. The key feature of this work is that the statistical equivalence does not depend on realizing all missing sensors, instead the equivalence is at the level of the sum co-array. We show simulation results that demonstrate the system equivalence of thinned arrays with about one-third of the active sensors compared to a ULA of equal aperture.
“[T]Hose Who Had Money Were Opposed to Us, and Those Who Were Our Friends Were Not the Moneyed Class”: Philadelphia and the 1837–1838 Canadian Rebellions

ABSTRACTIn early January 1838, weeks following a disastrous military defeat at the hands of the British at Saint-Eustache, in the British colony of Lower Canada, two patriotes leaders, Dr. Robert Nelson and Dr. Edmund O’Callaghan, arrived in Philadelphia. Their mission was to find military and financial support among local residents for the 1837 Rebellion. A few days later, they left empty-handed and disappointed. According to O’Callaghan, those who supported them were incapable to help, while those who had the means to offer concrete assistance were, quite simply, opposed to their crusade. Why did Nelson and O’Callaghan leave empty-handed? Were O’Callaghan’s assumptions about the people of Philadelphia correct? This article explains why the Patirote mission to Philadelphia failed and suggests that O’Callaghan was incorrect. The mission did not fail because their allies were too poor while those with money opposed them. Instead, though many actually hoped that the rebels succeeded and offered much moral s...
MicroRNAs as potential biomarkers to predict the risk of urinary retention following intradetrusor onabotulinumtoxin-A injection.

Aims MicroRNAs (miRs) control post-transcriptional gene expression, and this is relevant in understanding better chronic diseases and treatment outcomes. The role of miRs in the pathology and treatment outcomes of overactive bladder (OAB) is unknown. In this study, we assessed the differential expression of miRs in OAB patients responding with either normal or elevated post-void residual volumes (PVRs) ≥200 mL following intradetrusor injection of onabotulinumtoxin-A (onaBoNT-A). Methods Female OAB patients refractory to OAB drugs were consented for this study. Cystoscopic-guided punch bladder biopsy was obtained at the time of injection of onaBoNT-A 100 units. The expression of 13 miR species, selected for their known effect on neurotrophin expression and smooth muscle function, was measured. PVRs and urine nerve growth factor (NGF) levels were measured at baseline and at the follow-up visit. Results Fourteen patients with mean age of 66 years were consented. Of these patients, nine maintained PVRs <200 mL after onaBoNT-A injection to comprise the low PVR group. The other five patients with PVRs ≥200 mL comprised the high PVR group. The expression of miR221 and miR125b was upregulated by 11- and 2-fold, respectively, in patients who responded with low PVRs after onaBoNT-A (P < 0.05). Urine NGF levels at baseline were not different between the two groups. Conclusions This study suggests that deficiency in the pretreatment expression of miR221 and miR125b may predispose OAB patients to high PVRs following intradetrusor onaBoNT-A. Additional studies are needed to better understand the role of miRs in OAB.
Provider Concentration in Markets for Physician Services for Patients with Traditional Medicare

The geographic extent of markets for physicians is an important but little-explored issue for antitrust. Using patient flow data from a 2009 20% sample of Medicare beneficiaries, we define physician specialty-specific geographic markets for selected communities and calculate concentration within these markets. We find considerable variation in geographic market size by physician specialty and evidence of substantial concentration within physician markets, especially for specialists in smaller geographic areas. Additionally, given that our market definition methodology has been shown to define overly expansive markets, our concentration measures likely reflect a lower bound.
Abstract 100: An XY Sex Chromosome Complement in Females Confers Susceptibility and Rupture of Angiotensin II-induced Abdominal Aortic Aneurysms in Hypercholesterolemic Female Mice

Objective: We previously demonstrated that female mice are less susceptible to angiotensin II (AngII)-induced abdominal aortic aneurysms (AAAs) compared to males, a sex difference present in humans. Sex chromosome abnormalities, such as Turner’s syndrome (monosomy X), are associated with aortic vascular disease. In this study, we tested the hypothesis that an XY sex chromosome complement in females promotes AngII-induced AAAs. In addition, as previous studies demonstrated that testosterone promotes AngII-induced AAAs in male mice, we determined if testosterone would augment AAA severity in XY females. Methods and Results: Transgenic male mice with deletion of Sry from the Y-chromosome expressing Sry on autosomes (8-12 weeks of age) were bred to female Ldlr-/- mice to generate female mice with an XY or an XX sex chromosome complement. Female mice (XX and XY) were fed a Western diet and segregated into sham and ovariectomized (OVX) groups. Two weeks later, mice were implanted with osmotic minipumps to infuse AngII (1,000 ng/kg/min) for 28 days. The AAA incidence (XX sham, 40%; XX OVX 29%; XY sham, 71%; XY OVX, 57%, p=0.031) and rupture rate (XX sham, 0%; XX OVX 0%; XY sham, 35%; XY OVX, 29%, p=0.003) were significantly increased in XY compared to XX females. Internal abdominal aortic lumen diameters were significantly increased in XY OVX versus XX OVX female mice at day 27 (XY, 2.31 ± 0.14; XX, 1.58 ± 0.2, p= 0.009). Moreover, AAA external diameters were significantly increased in XY OVX versus XX OVX females (XY, 2.34 ± 0.15; XX, 1.71 ± 0.18, p=0.0004). Administration of testosterone to adult female XY mice as well as neonatal female mice markedly enhanced AAA rupture (maximum of 73%). DNA microarrays of abdominal aortas revealed that male specific genes on the Y chromosome and inflammatory genes were enriched in aortas from XY females, while genes that escape X-inactivation were enriched in aortas from XX females. Conclusion: These results demonstrate that an XY sex chromosome complement is sufficient to promote a high AAA incidence, and markedly increase AAA severity in female mice. Moreover, testosterone augmented AAA ruptures in XY females. Future studies will identify gene targets influenced by sex chromosome complement and/or testosterone.
Orientable Z_n-distance Magic Labeling of the Cartesian Product of Many Cycles

The following generalization of distance magic graphs was introduced in [2]. A directed Z_n-distance magic labeling of an oriented graph $\overrightarrow{G}=(V,A)$ of order n is a bijection $\overrightarrow{\ell}\colon V \rightarrow Z_n$ with the property that there is a $\mu \in Z_n$ (called the magic constant) such that w(x)= \sum_{y\in N_{G}^{+}(x)} \overrightarrow{\ell}(y) - \sum_{y\in N_{G}^{-}(x)} \overrightarrow{\ell}(y)= \mu$ for every x \in V(G). If for a graph G there exists an orientation $\overrightarrow{G}$ such that there is a directed Z_n-distance magic labeling $\overrightarrow{\ell}$ for $\overrightarrow{G}$, we say that G is orientable Z_n-distance magic and the directed Z_n-distance magic labeling $\overrightarrow{\ell}$ we call an orientable Z_n-distance magic labeling. In this paper, we find orientable Z_n-distance magic labelings of the Cartesian product of cycles. In addition, we show that even-ordered hypercubes are orientable Z_n-distance magic.
Combined Partial Penectomy With Bilateral Robotic Inguinal Lymphadenectomy Using Near-infrared Fluorescence Guidance.

Objective To describe our novel technique for performing a combined partial penectomy and bilateral robotic inguinal lymphadenectomy using intraoperative near-infrared (NIR) fluorescence guidance with indocyanine green (ICG) and the DaVinci Firefly camera system. Methods A 58-year-old man presented status post recent excisional biopsy of a 2-cm lesion on the left coronal aspect of the glans penis. Pathology revealed “invasive squamous cell carcinoma of the penis with multifocal positive margins.” His examination was suspicious for cT2 primary and his inguinal nodes were cN0. He was counseled to undergo partial penectomy with possible combined vs staged bilateral robotic inguinal lymphadenectomy. Preoperative computed tomography scan was negative for pathologic lymphadenopathy. Before incision, 5 mL of ICG was injected subcutaneously beneath the tumor. Bilateral thigh pockets were then developed simultaneously and a right, then left robotic modified inguinal lymphadenectomy was performed using NIR fluorescence guidance via the DaVinci Firefly camera. A partial penectomy was then performed in the standard fashion. Results The combined procedure was performed successfully without complication. Total operative time was 379 minutes and total robotic console time was 95 minutes for the right and 58 minutes to the left. Estimated blood loss on the right and left were 15 and 25 mL, respectively. A total of 24 lymph nodes were retrieved. Conclusion This video demonstrates a safe and feasible approach for combined partial penectomy and bilateral inguinal lymphadenectomy with NIR guidance using ICG and the DaVinci Firefly camera system. The combined robotic approach has minimal morbidity and avoids the need for a staged procedure. Furthermore, use of NIR guidance with ICG during robotic inguinal lymphadenectomy is feasible and may help identify sentinel lymph nodes and improve the quality of dissection. Further studies are needed to confirm the utility of NIR guidance for robotic sentinel lymph node dissection.
Narrar a Mariel: Espacialización y heterotopías del exilio cubano en la novela Boarding Home (1987) de Guillermo Rosales (1946–1993)

In this article I analyze the effects of the Cuban exodus in 1980 known as the Mariel boatlift, in Guillermo Rosales’s novel Boarding Home (1987). I argue that Mariel and the so-called marielitos are portrayed in the novel as offering a more complex view of an event that was stigmatized both by the Cuban government as well as by the American media. Marielitos, treated as the “scum” of society, were expelled from the island during a cleansing campaign (“basurizacion of the other” in Castillo Durante’s words). As a result, their abjection (Kristeva) was reflected in the spatiality of the margin: in the boarding home in the United States to which the protagonist was sent, and in the area of Miami known as Little Havana, where many of these immigrants lived. I propose to study the boarding home and Little Havana as heterotopic places (Foucault) in which the two utopias (and dystopias) involving the revolution and exile are distorted. I conclude that Rosales appeals to literature in order to react against the invisibility and/or stigma of the exodus, turning it into an act of defiance. Resumen En este trabajo analizo la novela Boarding Home (1987) del escritor cubano Guillermo Rosales a partir de su inscripcion dentro de las coordenadas que signaron el exodo cubano por el Mariel en 1980. Exploro como Mariel se vuelve un espacio simbolico de significacion desde donde se ofrece una mirada mucho mas compleja al evento estigmatizado tanto por la revolucion, como por los medios de prensa y la comunidad norteamericanos. La operacion de “basurizacion del otro”, de la “escoria” que lleva a cabo el gobierno cubano (Castillo Durante) tiene como consecuencia inevitable a la abyeccion (Kristeva), y ambos fenomenos se hacen visibles, materiales, en la espacializacion del margen, del exilio en la vida del protagonista como se comprueba con su vida en un home de Miami, y tras sus recorridos por la ciudad. Tanto el home como La Pequena Habana son lugares heterotopicos (Foucault) en donde opera una distorsion de las dos utopias (o distopias) que entranan la revolucion y el exilio. Concluyo que Rosales apela a la literatura como acto de resistencia ante la invisibilidad y el estigma del exodo.
Comment on "quantum bounce and cosmic recall".

A Comment on the Letter by [Alejandro Corichi and Parampreet Singh, Phys. Rev. Lett. 100, 161302 (2008)]. The authors of the Letter offer a Reply.
A comparison of adult and childhood progerias: Werner syndrome and Hutchinson-Gilford progeria syndrome.

The Werner syndrome, also known as progeria of the adult, and the childhood Hutchinson-Gilford Progeria Syndrome (hereafter Progeria), both serve as genetic disease models of human aging (Brown, 1979). A comparison of their similarities and differences may be useful in order to gain insight into the nature of the genetic mutations underlying these conditions. Their modes of inheritance indicate the involvement of a single gene. This implies that some specific genes may lead to a phenotype of greatly accelerated senescence and that such genes may have direct effects on the rate of aging. Determining the basic mechanisms involved in producing their phenotypes may point the way to an understanding of important pathogenetic aspects underlying the aging process.
Plasmid-Encoded Ion Transport Systems

Publisher Summary This chapter discusses plasmid-encoded ion transport systems. A wide variety of bacterial functions are encoded on extrachromosomal plasmid DNA. These include resistance to antibiotics, resistance to agents that damage DNA, restriction and modification of foreign DNA, metabolic functions mediated by enzyme production, bacteriocin, toxin, and antibiotic production, colonization and other virulence factors, and tumor production in plants. Although few in number, the ion transport systems described in the chapter are divided into three categories: (1) that which confers a specific biochemical utilization potential, (2) that which confers resistance to the toxic metal ions of cadmium, arsenate, arsenite, and mercury, and (3) that which confers a virulence property to an otherwise nonpathogenic bacterium, iron transport. Arsenate is toxic to bacteria because, as an analog of phosphate, it is transported by bacterial phosphate transport systems and interferes intracellularly with production of phosphorylated intermediates. Resistance to arsenicals is carried on both transmissible and nonconjugative plasmids and was found in bacteria isolated well before the advent of antibiotic use.
Survivability of moon systems around ejected gas giants

We examine the effects that planetary encounters have on the moon systems of ejected gas giant planets. We conduct a suite of numerical simulations of planetary systems containing three Jupiter-mass planets (with the innermost planet at 3 AU) up to the point where a planet is ejected from the system. The ejected planet has an initial system of 100 test-particle moons. We determine the survival probability of moons at different distances from their host planet, measure the final distribution of orbital elements, examine the stability of resonant configurations, and characterize the properties of moons that are stripped from the planets. We find that moons are likely to survive in orbits with semi-major axes out beyond 200 planetary radii (0.1 AU in our case). The orbital inclinations and eccentricities of the surviving moons are broadly distributed and include nearly hyperbolic orbits and retrograde orbits. We find that a large fraction of moons in two-body and three-body mean-motion resonances also survive planetary ejection with the resonance intact. The moon-planet interactions, especially in the presence of mean-motion resonance, can keep the interior of the moons molten for billions of years via tidal flexing, as is seen in the moons of the gas giant planets in the solar system. Given the possibility that life may exist in the subsurface ocean of the Galilean satellite Europa, these results have implications for life on the moons of rogue planets---planets that drift through the galaxy with no host star.
A Model-Based Approach to Quantify the Time-Course of Anti-Drug Antibodies for Therapeutic Proteins.

A mathematical antidrug antibody (ADA) model was developed to quantitatively assess immunogenicity for therapeutic proteins. The ADA model was built with antibody titer data in subjects from 10 clinical trials. The time course of the antibody titers was quantitatively characterized with a two-component semimechanistic model describing the double peaks of ADA titers. The relationship between antibody titer and incidence was also explored. The ADA incidences in subjects from 12 clinical trials were used for internal and external validations. The ADA titers reasonably predicted the incidence of antibody. The model-predicted elimination rate constant for antibody titer was 14.1 × 10-3 day-1 and 8.1 × 10-3 day-1 in healthy subjects and patients, respectively. This research provided a useful tool to quantitatively evaluate immunogenicity and its impact for therapeutic proteins.
Magnetic Liver Retraction: an Incision-Less Approach for Less Invasive Bariatric Surgery

In bariatric surgery, retraction of the liver is essential to ensure appropriate visualization of the surgical field. Many devices are currently employed for this purpose. Generally, these devices require constant use of a port, or an additional incision. Magnetic technology provides a novel solution, by allowing liver retraction during bariatric procedures that do not require a dedicated port nor an extra incision. Retrospective review of consecutive patients who underwent magnetic-assisted liver retraction during primary or revisional laparoscopic bariatric surgery at the Duke Center for Metabolic and Weight Loss Surgery between October 2016 and August 2017. The 73 cases were comprised of 29 primary sleeve gastrectomies, 24 gastric bypasses, 10 duodenal switches, 3 gastric band removals, and 7 revisions. All cases were completed laparoscopically. Mean pre-operative BMI was 43.6 kg/m2 (range 18.3–67.7 kg/m2). Mean operative times for primary cases were similar to published averages. Two patients experienced minor 30-day morbidities, neither of which were attributed to the device and did not require further interventions. There were no 30-day mortalities. Surgeons described subjective overall surgical exposure as adequate and device utilization as technically simple even for the large livers. Magnetic-assisted retraction is a novel approach that allows a safe, reproducible, incision-less technique for unconstrained, port-less intra-abdominal mobilization. The device successfully permitted optimal liver retraction during laparoscopic bariatric surgery, enhancing surgical exposure while decreasing the number of abdominal incisions.
Proteomic Investigations of Autism Spectrum Disorder: Past Findings, Current Challenges, and Future Prospects

Proteomics is a powerful tool to study biological systems and is potentially useful in identifying biomarkers for clinical screening and diagnosis, for monitoring treatment, and for exploring pathogenetic mechanisms in autism. Unlike numerous other experimental approaches employed in autism research, there have been few proteomic-based analyses. Herein, we discuss the findings of studies regarding autism that utilized a proteomic approach and review key considerations in sample acquisition, processing, and analysis. Most proteomic studies on autism used blood or other peripheral tissues. Few studies used brain tissue, the main site of biological difference between persons with autism and others. The findings have varied and are not yet replicated. Some showed abnormalities of synaptic proteins or proteins of mitochondrial bioenergetics. Various abnormalities of proteins relating to immune processes and lipid metabolism have also been noted. Whether any of the proteomic differences between autism and control cases are primary or secondary phenomena is currently unclear. Consequently, no definitive biomarkers for autism have been identified, and the pathophysiological insights provided by proteomic studies to date are uncertain in the absence of replication. Based on this body of work and the challenges in using proteomics to study autism, we suggest considerations for future study design. These include attention to subject and specimen inclusion/exclusion criteria, attention to the state of specimens prior to proteomic analysis, and use of a replicate set of specimens. We end by discussing especially promising applications of proteomics in the study of autism pathobiology.
IVABRADINE-INDUCED TORSADES DE POINTES IN PATIENT WITH CONCURRENT USE OF HIGH DOSE METOPROLOL AND DIURETICS

SHIFT trial showed reduced hospital admission rates and mortality with ivabradine, in patients with refractory sustained sinus tachycardia and heart failure with reduced ejection fraction (HFrEF). We present a case of a patient with normal QTc on maximum beta blocker therapy and aggressive diuretics
Epidemiologic and Outcome Analysis of Epistaxis in a Tertiary Care Center Emergency Department

BackgroundThe association between hypertension and recurrent epistaxis is controversial. The objective of this study is to examine the factors associated with recurrent epistaxis visits to the emer...
Northwestward cropland expansion and growing urea-based fertilizer use enhanced NH 3 emission loss in the contiguous United States

Abstract. The increasing demands of food and biofuel have promoted century-long cropland expansion and nitrogen (N) fertilizer enrichment in the United States. However, the role of such long-term human activities in influencing the spatiotemporal patterns of Ammonia (NH3) emission remains poorly understood. Based on an empirical model including climate, soil properties, N fertilizer management, and cropland distribution history, we have quantified monthly fertilizer-induced NH3 emission across the contiguous U.S. from 1900 to 2015. Our results show that N fertilizer-induced NH3 emission in the U.S. has increased from
Rate of progression from mild cognitive impairment to dementia in an essential tremor cohort: A prospective, longitudinal study.

Abstract Background Essential tremor (ET), among the most common neurological diseases, is associated with cognitive dysfunction. Yet, nearly all knowledge of ET-related cognitive impairment is static and cross-sectional (e.g., prevalence), with virtually no dynamic information (i.e., course and progression, conversion rates, and clinical outcomes). Objectives To quantify the rate of progression from mild cognitive impairment (MCI) to dementia in a cohort of elderly ET cases. Methods 167 ET cases, enrolled in a prospective, longitudinal, clinical-pathological study, underwent an extensive neuropsychological testing battery at baseline (T1), 1.5 years (T2), and 3 years (T3). Results of these assessments informed clinical diagnoses of normal cognition (ET-NC), MCI (ET-MCI), and dementia (ET-D). Results At baseline, 26 cases (82.7 ± 7.7 years) were diagnosed with ET-MCI and were available for follow-up at T2. At T2, three of 26 (11.5%) had converted to ET-D. At the start of T2, 23 cases (83.6 ± 7.7 years) were diagnosed with ET-MCI and were available for follow-up at T3. At T3, six of 23 (26.1%) converted to ET-D. The average annual conversion rate from ET-MCI to ET-D was 12.5%. Conclusions The study of cognitive impairment in ET is a nascent field, with limited data. We show that the conversion rate from ET-MCI to ET-dementia was 12.5%. Available studies on historical controls have reported conversion rates of 2.6–6.3%. Data such as these systematically fill gaps in knowledge, creating a scientifically-derived knowledge base to guide physicians and patients in clinical settings.
Bond Number Revisited: Axisymmetric Macroscopic Pendant Drop.

The numbers Rbθ and Rbr introduced recently (Berim, G.O.; Ruckenstein, E. J. Phys. Chem., 2019, 123, 10294-10300) to characterize the cylindrical pendant drops hanging from the solid surface are mo...
US EPA's regulatory pesticide evaluations need clearer guidelines for considering mammary gland tumors and other mammary gland effects.

Abstract Breast cancer risk from pesticides may be missed if effects on mammary gland are not assessed in toxicology studies required for registration. Using US EPA's registration documents, we identified pesticides that cause mammary tumors or alter development, and evaluated how those findings were considered in risk assessment. Of 28 pesticides that produced mammary tumors, EPA's risk assessment acknowledges those tumors for nine and dismisses the remaining cases. For five pesticides that alter mammary gland development, the implications for lactation and cancer risk are not assessed. Many of the mammary-active pesticides activate pathways related to endocrine disruption: altering steroid synthesis in H295R cells, activating nuclear receptors, or affecting xenobiotic metabolizing enzymes. Clearer guidelines based on breast cancer biology would strengthen assessment of mammary gland effects, including sensitive histology and hormone measures. Potential cancer risks from several common pesticides should be re-evaluated, including: malathion, triclopyr, atrazine, propylene oxide, and 3-iodo-2-propynyl butylcarbamate (IPBC).
Therapeutic Effects of Expressive Arts Curriculum in Composition Courses

An instructor of collegiate Rhetoric and Composition courses uses practitioner action research to study the effects of curriculum centered around Expressive Arts techniques. Over the course of a se...
Nuclear quantum effects on the thermodynamic, structural, and dynamical properties of water.

We perform path-integral molecular dynamics (PIMD) simulations of H2O and D2O using the q-TIP4P/F model. Simulations are performed at P = 1 bar and over a wide range of temperatures that include the equilibrium (T ≥ 273 K) and supercooled (210 ≤ T 1 bar and that such a LLCP generates a maximum in CP(T) and κT(T) at 1 bar. Consistent with this hypothesis and in particular, with experiments, we find a maximum in the κT(T) of q-TIP4P/F light and heavy water at T ≈ 230–235 K. No maximum in CP(T) could be detected down to T ≥ 210 K. We also calculate the diffusion coefficient D(T) of H2O and D2O using the ring-polymer molecular dynamics (RPMD) technique and find that computer simulations are in remarkable good agreement with experiments at all temperatures studied. The results from RPMD/PIMD simulations are also compared with the corresponding results obtained from classical MD simulations of q-TIP4P/F water where atoms are represented by single interacting sites. Surprisingly, we find minor differences in most of the properties studied, with CP(T), D(T), and structural properties being the only (expected) exceptions.
Performance Budgeting in the American States What's Law got to do with it?

This study examines the content of performance budgeting legislation and its relationship to the quality of implemented performance budgeting systems. Recent research indicates that states with well-functioning performance budgeting systems are more likely to have enacted pertinent laws than states with weak or no performance budgeting system. The authors find that performance budgeting legislation containing detailed instructions on the development, reporting, and use of performance data contributes to stronger use of performance budgeting systems in state governments.
Emotional Intelligence and Role-Modeling Nursing's Soft Skills.

ABSTRACT Developing and enhancing emotional intelligence in nursing students is a necessary element of nursing education. Various evidence-based strategies to cultivate emotional intelligence characteristics, such as self-reflection, self-awareness, problem-solving, and interprofessional collaboration in nursing students, are described along with the value of role-modeling Christian qualities that promote empathy and compassion in nursing graduates.
The Victimization of Children: Emerging Issues

* About the Contributors * Preface (Janet L. Mullings, James W. Marquart, and Deborah J. Hartley) * EMERGING ISSUES IN CHILD VICTIMIZATION * Victimization of Youths on the Internet (Kimberly J. Mitchell, , David Finkelhor, and Janis Wolak) * Children as Victims of War and Terrorism (Judith Myers-Wall) * No Safe Place: Assessing Spatial Patterns of Child Maltreatment Victimization (Derek J. Paulsen) * Religion-Related Child Physical Abuse: Characteristics and Psychological Outcomes (Bette L. Bottoms, Michael Nielsen, Rebecca Murray, and Henrietta Filipas) * The Pedophile and the Pious: Towards A New Understanding of Sexually Offending and Non-Offending Roman Catholic Priests (Gerard J. McGlone) * RECENT TRENDS IN RESPONSE TO CHILD VICTIMIZATION * The Role of Health Care Professionals in the Response to Child Victimization (Vincent J. Palusci) * Children with Disabilities: Abuse, Neglect, and the Child Welfare System (Christina M. Bruhn) * EMERGING LEGAL ISSUES PERTAINING TO CHILD VICTIMIZATION * Fetal Homicide: Emerging Statutory and Judicial Regulation of Third-Party Assaults Against the Fetus (Jeff Maahs) * Legal and Social Issues Surrounding Closed-Circuit Television Testimony of Child Victims and Witnesses (Katherine J. Bennett) * Addressing Family Violence Within Juvenile Courts: Promising Practices to Improve Intervention Outcomes (Sarah M. Buel) * Index * Reference Notes Included
Pediatrician Perceptions of the Patient-Centered Medical Home Model

PEDIATRICIAN PERCEPTIONS OF THE PATIENT-CENTERED MEDICAL HOME MODEL By Christopher Chambers Ray A thesis submitted in partial fulfillment of the requirements for the degree of Master of Science at Virginia Commonwealth University Virginia Commonwealth University, 2011 Advisor: Sarah H. Elsea, Ph.D., F.A.C.M.G. Associate Professor, Departments of Pediatrics and Human and Molecular Genetics The Patient-Centered Medical Home (PCMH) is an emerging model of health care designed to provide a simpler, more effective health care experience. The model places heavy emphasis on the concept of every patient having a ―personal physician‖ who is the point of access for all health care needs and concerns. The personal physician integrates all relevant health care information to provide the patient with a holistic picture of his health. The supposed benefits of the PCMH model include an improved patient experience, increased effectiveness of care, increased efficiency of care, greater access to care, among others. Only now is evidence beginning to emerge to substantiate those clams. As evidence continues to emerge supporting the PCMH model, one area that warrants further study is how those directly involved in health care perceive this model.