cssi/SciSciGPT-SciSciNet huggingface dataset:
Experimental and numerical analysis of anti-icing a GLARE laminate

Abstract This study aimed at developing a numerical model to estimate the power consumption of a GLAss fiber REinforced aluminum-based electro-thermal ice protection system for anti-icing. The GLAss fiber REinforced aluminum laminate was embedded with recurred S-shaped copper meshes thermally energized by a surface power density. The model determined the influence of a forced convective heat loss and copper-mesh dimension on anti-icing. As a test case, the numerical model addressed the anti-icing performance of a GLAss fiber REinforced aluminum 5A-3/2 laminate at a sub-freezing ambient temperature of 267.95 K. The model demanded a surface power density of 13.03 kW/m2 in order to keep the temperature of the outer aluminum-skin at 285.44 K, which was clearly beyond the water freezing point. The numerically predicted power consumption for anti-icing was in excellent agreement with that from the experiment. The experiment was conducted in a miniature icing wind tunnel by incorporating the comparable icing condition of the numerical analysis. In the experiment, an infrared thermography camera determined the spatio-temporal temperature history of the outer aluminum skin in contact with the free-stream. The infrared thermography camera measurements of surface temperature collapsed in close proximity to that from the numerical analysis. The outcomes of this study will consolidate the confidence of aircraft manufacturers on the proposed anti-icing system.
Identification and characterization of GLOBE, a major gene controlling fruit shape and impacting fruit size and marketability in tomato.

Within large-fruited germplasm, fruit size is influenced by flat and globe shapes. Whereas flat fruits are smaller and retain better marketability, globe fruits are larger and more prone to cuticle disorders. Commercial hybrids are often developed from crosses between flat and globe shaped parents because flat shape is thought to be dominant and fruit size intermediate. The objectives of this study were to determine the genetic basis of flat/globe fruit shape in large-fruited fresh-market tomato germplasm and to characterize its effects on several fruit traits. Twenty-three advanced single plant selections from the Fla. 8000 × Fla. 8111B cross were selectively genotyped using a genome-wide SNP array, and inclusive composite interval mapping identified a single locus on the upper arm of chromosome 12 associated with shape, which we termed globe. A 238-plant F2 population and 69 recombinant inbred lines for this region from the same parents delimited globe to approximately 392-kilobases. A germplasm survey representing materials from multiple breeding programs demonstrated that the locus explains the flat/globe shape broadly. A single base insertion in an exon of Solyc12g006860, a gene annotated as a brassinosteroid hydroxylase, segregated completely with shape in all populations tested. CRISPR/Cas9 knock out plants confirmed this gene as underlying the globe locus. In silico analysis of the mutant allele of GLOBE among 595 wild and domesticated accessions suggested that the allele arose very late in the domestication process. Fruit measurements in three genetic backgrounds evidenced that globe impacts fruit size and several fruit shape attributes, pedicel length/width, and susceptibility of fruit to weather check. The mutant allele of GLOBE appears mostly recessive for all traits except fruit size where it acts additively.
Clinical Outcomes of Daptomycin Versus Anti-Staphylococcal Beta-Lactams in Definitive Treatment of Methicillin-susceptible Staphylococcus aureus Bloodstream Infections.

Abstract Objectives Staphylococcus aureus (S. aureus) is the leading cause of bacteraemia and infective endocarditis worldwide. The preferred management of patients with methicillin-susceptible S. aureus (MSSA) bacteraemia includes definitive therapy with intravenous anti-staphylococcal beta-lactam (ASBL) antibiotics. Daptomycin (DAP) has been targeted as a viable substitute for beta-lactam allergic or intolerant patients. Methods This single-center retrospective cohort study assessed clinical outcomes of DAP compared with ASBL antibiotics [nafcillin (NAF) or cefazolin (CFZ)] for the treatment of MSSA bacteraemia in patients hospitalised from 01 November 2011 to 31 October 2018. The primary outcome was a composite of the following: clinical failure, MSSA recurrence and MSSA persistence or inpatient infection-related mortality. Secondary outcomes included duration of MSSA bacteraemia, infection-related length of stay, infection-related 90-day readmission, 30-day all-cause mortality, and adverse events necessitating a change in therapy. Results Of 89 patients with MSSA bacteraemia who were included: 29 received DAP, 30 received NAF and 30 received CFZ. There was no difference in the composite primary outcome in patients treated with DAP compared with ASBL (10% vs. 5%, P = 0.39). The DAP cohort had a longer hospital length of stay compared with the ASBL group (20 days vs. 11.5 days, P = 0.0007). No differences were detected between other secondary outcomes. Conclusion This study suggests that DAP may serve as a comparable alternative to ASBLs for treatment of MSSA bacteraemia, as no differences in clinical outcomes were identified. Larger studies are needed to confirm these findings.
Evaluating the efficacy of aluminide coatings to improve oxidation resistance of high performance engine valve alloys

Abstract Increasing peak cylinder pressures and operating temperatures of turbo-charged internal combustion engines (ICEs) engines present new challenges for existing materials employed in engine exhaust valves. Oxidation induced degradation of current Ni based alloys for these components will be a life-limiting mechanism while strict cost margins in the automotive transportation industry further limit the choice of suitable candidate materials. Metallic diffusion aluminide coatings can provide a cost-effective way to improve the oxidation resistance of underlying materials. In this study, the high temperature oxidation behavior of diffusion nickel aluminide coatings on two Ni based alloys (commercially available alloy 31V and a developmental alloy) during cyclic oxidation behavior in air+10% H2O at 900 °C was investigated. A complete depletion of the beneficial Al-rich β-(NiFe)Al phase was observed in the coating on alloy 31V while a significant fraction of this phase was retained in the coating on the second alloy. A coupled thermodynamic-kinetic model showed that the disappearance of the Al-rich phase in the coating on 31V was mainly due to the combined effect of steeper chemical potential gradients of Al and Ti between the coating and the substrate and their faster diffusivities compared to the coated developmental alloy. A higher content of Fe was shown to support the retention of β-(NiFe)Al phase in the coating on the developmental alloy while the presence of Ti in the alloy was shown to be detrimental for long-term coating performance.
Binocular Benefit Following Monocular Subretinal AAV Injection in a Mouse Model of Autosomal Dominant Retinitis Pigmentosa (adRP)

Autosomal dominant retinitis pigmentosa (adRP) is frequently caused by mutations in RHO, the gene for rhodopsin. In previous experiments in dogs with the T4R mutation in RHO, an AAV2/5 vector expressing both an shRNA directed to human and dog RHO mRNA and an shRNA-resistant human RHO cDNA (AAV-RHO820-shRNA820) prevented retinal degeneration for more than 8 months following injection. To confirm that this same vector could protect the retinas of a different species and bearing a different RHO mutation, we injected mice transgenic for human P23H RHO at postnatal day 30 in one eye. For nine months, we monitored their retinal structure using spectral-domain optical coherence tomography (SD-OCT) and retinal function using electroretinography (ERG). We compared these to P23H RHO transgenic mice injected with AAV-GFP. Though retinas continued to thin over time, compared to control injected eyes, AAV-RHO820-shRNA820 slowed the loss of photoreceptor cells and decreased ERG amplitudes in AAV-RHO820-shRNA820 eyes during the nine-month study period. Unexpectedly, we also observed preservation of retinal structure and function in the untreated contralateral eyes of AAV-RHO820-shRNA820 treated mice. PCR analysis and western blots provided evidence that a low amount of vector from injected eyes was present in uninjected eyes.
The Ties That Cope? Reshaping Social Connections in Response to Pandemic Distress

The COVID-19 pandemic introduced unprecedented challenges for individuals in organizations to maintain their interpersonal connections, which are critical for resource exchange. Because prior research has focused on how networks gradually evolve over time, there is little insight into how an exogenous shock, such as the pandemic, would reshape informal ties among colleagues that comprise their social networks. Drawing upon the optimal matching theory of social support, we develop a psychological perspective on how individuals recalibrate their social ties to enable coping with the uncertainty and anxiety introduced by the pandemic shock. We test our theory using a three-wave network data set from a sample of colocated, full-time MBA students before and after the onset of the pandemic. Following the onset of the pandemic, we found there was an overall reduction in the maintenance of advice ties. We also found that emotional exhaustion exacerbated this effect, and when emotional exhaustion was high, racially homophilous advice ties were just as likely to be dropped as heterophilous advice ties. We also found, unexpectedly, that COVID-19 reduced the maintenance of friendship ties, perhaps because social distancing reduced emotional support opportunities. Thoughts of anticipated inclusion mitigated this negative effect, particularly for racially heterophilous friendships. Individuals in organizations have psychological agency for reordering their social networks to respond to demands created by existential crises.
Experimental Investigation of Shock-Shock Interactions Over a 2-D Wedge at M=6

The effects of fin-leading-edge radius and sweep angle on peak heating rates due to shock-shock interactions were investigated in the NASA Langley Research Center 20-inch Mach 6 Air Tunnel. The fin model leading edges, which represent cylindrical leading edges or struts on hypersonic vehicles, were varied from 0.25 inches to 0.75 inches in radius. A 9deg wedge generated a planar oblique shock at 16.7deg to the flow that intersected the fin bow shock, producing a shock-shock interaction that impinged on the fin leading edge. The fin angle of attack was varied from 0deg (normal to the free-stream) to 15deg and 25deg swept forward. Global temperature data was obtained from the surface of the fused silica fins through phosphor thermography. Metal oil flow models with the same geometries as the fused silica models were used to visualize the streamline patterns for each angle of attack. High-speed zoom-schlieren videos were recorded to show the features and temporal unsteadiness of the shock-shock interactions. The temperature data were analyzed using one-dimensional semi-infinite as well as one- and two-dimensional finite-volume methods to determine the proper heat transfer analysis approach to minimize errors from lateral heat conduction due to the presence of strong surface temperature gradients induced by the shock interactions. The general trends in the leading-edge heat transfer behavior were similar for the three shock-shock interactions, respectively, between the test articles with varying leading-edge radius. The dimensional peak heat transfer coefficient augmentation increased with decreasing leading-edge radius. The dimensional peak heat transfer output from the two-dimensional code was about 20% higher than the value from a standard, semi-infinite one-dimensional method.
Impact of Severity-Adjusted Workload on Health Status of Patients Discharge from an ICU

We examine whether workload has an impact on a direct measure of the health status of patients discharged from Intensive Care Units (ICUs). We use data collected from the medical ICU and the surgical ICU of a major teaching hospital and a relatively new measure of patient acuity called the Rothman Index (RI). The RI is frequently updated during a patient’s hospital stay, which enables us to track patients health status very close to the time of their ICU discharge. Leveraging the RI, we measure ICU workload in a novel way that takes into account not only the census but also patient acuity. To our knowledge, this is the first study to show that more acutely ill patients are discharged from an ICU when the severity-adjusted workload is high rather than low. Further, we find that higher severity-adjusted workload is associated with ICU discharge times that start earlier and end later, a shorter ICU length-of-stay (LOS), and an increased likelihood of discharge to a step-down unit. We also find that downstream unit census influences the effect of workload on health status at ICU discharge.
Experimental autoimmune myasthenia gravis in B10.BV8S2 transgenic mice: preferential usage of TCRAV1 gene by lymphocytes responding to acetylcholine receptor.

Multiple TCRBV genes have been implicated in experimental autoimmune myasthenia gravis (EAMG) pathogenesis in susceptible H-2(b) strains of mice. We studied the contribution of specific TCRBV and AV genes in EAMG pathogenesis using B10.BV8S2 transgenic mice (H-2[b]). The TCR transgenic mice predominantly have TCRBV8S2 transgene, but can use any of the endogenous AV gene repertoire. The transgenic mice were immunized with acetylcholine receptor (AChR) in CFA and evaluated for EAMG pathogenesis. Although the lymphocyte responses to AChR in B10.BV8S2 transgenic and nontransgenic TCR wild-type mice were equivalent, a marked reduction in lymphocyte response to the dominant AChR alpha chain peptide 146-162 was observed in the TCR transgenic mice. After boosting with AChR in CFA, anti-AChR Abs were detected in the serum, and 14 of 42 (33%) of the TCR transgenic mice developed clinical EAMG. Furthermore, EAMG in TCR transgenic mice was prevented by treatment with mAb to TCRBV8, which depleted BV8-expressing T cells. Cloning and sequencing of TCRAV genes from AChR-reactive T cells from B10.BV8S2 transgenic mice revealed a pattern of restricted TCRAV gene usage. The majority (60%) of the clones sequenced showed a sequence identical with that of the TCRAV1S8 gene. In the normal spleen cells of TCR transgenic mice, AV gene usage was more random. Thus, despite the presence of a complete endogenous TCRAV repertoire in B10.BV8S2 transgenic mice, T cells responding to AChR preferentially used a single endogenous TCRAV gene, thus implicating the involvement of the TCRAV1S8 gene in EAMG pathogenesis.
Relationship Termination and the Fisher Divorce Adjustment Scale

The purpose of the prcscnt study was to examine the differences and similarities in relationshio-termination adiustment between divorced and non-marital populat~ons. The two po$dations have becn assumed to be similar, but this assumption has not been investigated formally. The present sample consisted of 90 volunteers from eithcr a divorce support group or the student population at a midwestern university who completed a modified vcrsion of the Fisher Divorce Adjustment Scale (FDAS). A MANOVA found a significant difference in the FDAS scores based upon the type of relationship (divorced or ended long-term romantic). Follow-up ANOVAS indicated that the primary difference between the two groups was that the divorced group was more disentangled from the former relationship than the non-marital group. No significant sex differences and no significant relationship x sex interactions were found, which contradicts previous research. Although originally designed for divorced populations, the FDAS appears applicab...
Inhibition of Apoptosis by Progesterone in Cardiomyocytes

While gender-based differences in heart disease have raised the possibility that estrogen (ES) or progesterone (PG) may have cardioprotective effects, recent controversy regarding hormone replacement therapy has questioned the cardiac effects of these steroids. Using cardiomyocytes, we tested whether ES or PG has protective effects at the cellular level. We found that PG but not ES protects cardiomyocytes from apoptotic cell death induced by doxorubicin (Dox). PG inhibited apoptosis in a dose dependent manner, by 12 ± 4.0% at 1 μM and 60 ± 1.0 % at 10 μM. The anti-apoptotic effect of PG was also time dependent, causing 18 ± 5% or 62 + 2% decrease in caspase-3 activity within 1 or 72 hours of pretreatment. While PG causes nuclear translocation of its receptor within 20 mins, the cytoprotective effect of PG was cancelled by mifepristone (MF), a PG receptor antagonist. Analyses using Affymetrix high-density oligonucleotide array and RT-PCR found that PG induced Bcl-xL, metallothionine, NADPH quinone oxidoreductase 1, glutathione peroxidase-3, and 4 isoforms of glutathione S-transferase. Western blot analyses revealed that PG indeed induced an elevation of Bcl-xL protein in a dose and time dependent manner. Nuclear run-on assay indicated that PG induced Bcl-xL gene transcription. Inhibiting the expression of Bcl-xL using siRNA reduced the cytoprotective effect of PG. Our data suggests that PG induces a cytoprotective effect in cardiomyocytes in association with induction of Bcl-xL gene.
Integrating the how and why of within-individual and among-individual variation and plasticity in behavior

Although phenotypic variation within and among individuals in the same population may represent ‘noise’, it can also be the adaptive plasticity that allows organisms to adjust to varying environments or the heritable variation that fuels evolutionary change. Behavioral variation arises from a complex combination of adaptive and non-adaptive individual plasticity and consistency. Differentiating these sources of behavioral variation will require an integrated combination of evolutionary and mechanistic understanding. Yet, this integration comes with a variety of challenges. Here I argue that we will need concrete a priori predictions to make sense of the large and complex datasets this integration will require.
Guidelines for the specification of models to be used in design-oriented simulations

Simulation-based design requires models at many levels of detail. In the early stages, models must approximate the coarse behavior of the system across many domains -- power, efficiency, cost, size, and weight. In later stages, the models must represent the system with increasing accuracy -- including dynamic performance, controllability, and other more-subtle manifestations. In this work, we focus on specification of the models for a simulation-based design of ship power systems. We address the issues of levels of detail in models, definition of model ports to support substitution of models at increasing levels of detail, and the application of multiple analyses to one set of simulation models. Eventually, we tackle very detailed issues such as insulation coordination and grounding scheme that are not at all important in the conceptual stages of design.
Evidence for early and progressive ultrasonic vocalization and oromotor deficits in a PINK1 gene knockout rat model of Parkinson's disease

Parkinson's disease (PD) is a progressive neurodegenerative disease that leads to a wide range of motor and nonmotor deficits. Specifically, voice and swallow deficits manifest early, are devastating to quality of life, and are difficult to treat with standard medical therapies. The pathological hallmarks of PD include accumulation of the presynaptic protein α-synuclein (αSyn) as well as degeneration of substantia nigra dopaminergic neurons. However, there is no clear understanding of how or when this pathology contributes to voice and swallow dysfunction in PD. The present study evaluates the effect of loss of function of the phosphatase and tensin homolog-induced putative kinase 1 gene in rats (PINK1–/–), a model of autosomal recessive PD in humans, on vocalization, oromotor and limb function, and neurodegenerative pathologies. Behavioral measures include ultrasonic vocalizations, tongue force, biting, and gross motor performance that are assayed at 2, 4, 6, and 8 months of age. Aggregated αSyn and tyrosine hydroxylase immunoreactivity (TH-ir) were measured at 8 months. We show that, compared with wild-type controls, PINK1–/– rats develop 1) early and progressive vocalization and oromotor deficits, 2) reduced TH-ir in the locus coeruleus that correlates with vocal loudness and tongue force, and 3) αSyn neuropathology in brain regions important for cranial sensorimotor control. This novel approach of characterizing a PINK1–/– genetic model of PD provides the foundational work required to define behavioral biomarkers for the development of disease-modifying therapeutics for PD patients. © 2015 Wiley Periodicals, Inc.
An Approach to Selecting Thread + Process Mixes for Hybrid MPI + OpenMP Applications

Hybrid MPI + OpenMP is a popular means of programming modern machines that feature substantial parallelism both off-node and on-node. Determining the right mix of the two programming models to use, however, is not as straightforward as simply using exclusively OpenMP on-node and limiting MPI to only inter-node communication. We present a step-by-step methodology to help make the decision of which mix of the two programming models to use. It starts with an estimate of the performance of a generic hybrid application on a given machine and incorporates additional available information about the specific application and the machine to provide guidance for selecting effective mixes of MPI processes and OpenMP threads to use when running that application on the machine in question. We validate our approach on four different applications on an IBM Blue Gene/Q, a Cray XK7, and a Cray XC30.
Ethanol disrupts and decreases the regulated body temperature differentially in C57BL/6J and DBA/2J mice

Two inbred mouse strains, C57BL/6J (B6) and DBA/2J (D2), were evaluated for effects of ethanol on thermoregulation. Continuous recording of core temperature (Tc) from undisturbed animals at an ambient temperature (Ta) of 27 degrees C indicated Tc was similar for both strains during active (approximately 38.0 degrees C) and inactive (approximately 36.7 degrees C) periods. Ethanol-injections of 1.5, 2.5, 3.5, and 4.5 g/kg in an environment where Ta rose and fell at 6-min intervals, reaching extremes of 14 and 42 degrees C, produced dose-dependent falls in Tc for both strains. The changes in Ta produced fluctuations in Tc under all conditions. The amplitude of these fluctuations in Tc was used as a measure of physiological disruption. Dose-dependent increases in disruption were found for both strains. At a constant 26 degrees C Ta, ethanol produced dose-related increases in tail temperature. Responses after ethanol administration were different for B6 and D2 mice. The results indicate regulated temperature is similar for B6 and D2 strains. Regulated temperature is decreased more by ethanol for B6 mice, whereas disruption of thermoregulation by ethanol is greater for D2 mice.
Evaluation of the HOOF-Print assay for typing Brucella abortus strains isolated from cattle in the United States: results with four performance criteria.

Background A fundamental question that arises during epidemiological investigations of bacterial disease outbreaks is whether the outbreak strain is genetically related to a proposed index strain. Highly discriminating genetic markers for characterizing bacterial strains can help in clarifying the genetic relationships among strains. Under the auspices of the European Society of Clinical Microbiology and Infectious Diseases, the European Study Group for Epidemiological Markers (ESGEM) established guidelines for evaluating the performance of typing systems based of a number of criteria. Recently, HOOF-Print genotype analysis, a new method for typing Brucella abortus strains based on hypervariability at eight tandem repeat loci, was described. This paper evaluates the HOOF-Print assay by four of the criteria set out by the ESGEM: typeability, reproducibility, power of discrimination, and concordance with other typing methods.
Development and validation of the Rapid Estimate of Adult Literacy in Vascular Surgery (REAL_VS)

The purposes of this study were to develop and validate the (1) Rapid Estimate of Adult Literacy in Vascular Surgery (REAL_VS) for researchers studying the impact of literacy skills as related to vascular surgery-related knowledge and outcomes and (2) short version of the REAL_VS (REAL_VSs) to allow clinicians to gauge their patients' familiarity with vascular surgery-related terms. A three-phase process was used to identify potential words for inclusion in the REAL_VS, including reviewing Internet-based patient education material content and listening to a random sample of 50 archived audiorecordings of vascular surgeon-patient encounters. The REAL_VS was composed of 75 terms (e.g., stent, gangrene, invasive, aneurysm) of varying pronunciation difficulty. One hundred fifty-two English-speaking patients (>or=18 years of age) attending a university-based vascular surgery clinic were recruited to participate in this study (mean age = 61.4 +/- 14.6 years). During face-to-face interviews, patients' sociodemographic information was collected, and patients were administered the widely used Rapid Estimate of Adult Literacy in Medicine (REALM) and REAL_VS. Mean scores on the REALM (56.9 +/- 14.0) and REAL_VS (63.3 +/- 15.6) were highly correlated (Spearmans rank correlation [rho] = 0.91; p < 0.00). Internal consistency of the REAL_VS (Cronbachs alpha = 0.98) was excellent. Mean scores on the REAL_VSs (4.1 +/- 2.7) were highly correlated with both the REALM (rho = 0.82; p < 0.00) and REAL_VS (rho = 0.94; p < 0.00). Internal consistency, measured using Cronbachs alpha, of the REAL_VSs was 0.86. This study demonstrates that both the REAL_VS and REAL_VSs are both promising tools for use in vascular surgery research and clinical practice, respectively.
The Development of Statistical Indices for Detecting Cheaters

Abstract Comparison data on SAT were collected on pairs of examinees in three samples for later use in detecting instances of willful copying. In each sample the answer sheet of each examinee was compared with the answer sheet of every other examinee to determine the expected degree of similarity among answer sheets for “honest” examinees. Eight detection indices were developed and bivariate distributions were run for possible operational use in making future judgments regarding examinees who were actually suspected of copying. The results of a series of analyses permitted the elimination of six of the eight indices. The remaining two have been used successfully at Educational Testing Service since 1970.
Motion habituation: Inverted self-motion perception and optokinetic after-nystagmus

The oculomotor and perceptual after-effects (AE) of optokinetic motion stimulation as well as the adaptive changes during stimulation were studied. The intensity and duration of optokinetic after-nystagmus (OKAN) and self-motion after-sensation (CV) are a function of stimulus duration. The direction is a result of two competing processes: positive tonus continuing the actual response to the stimulus and negative tonus causing a reversal in direction. Positive AEs increase with stimulus durations up to 1 min; the negative AEs increase up to the longest stimulus duration tested (15 min) and by antagonizing the positive AEs shorten their duration once stimulus duration exceeds 3 min. Negative AEs are interpreted as the consequence of a central counter-regulation to the actual stimulus effects: motion habituation.
The Distortion of Self-Perception by Learned Helplessness

This study examined the impact of learned helplessness on self-perception of competence. The participants were 180 undergraduates who were placed in control, failure, or success groups where they were given a list of traits on which to evaluate themselves, followed by an anagram-solution test. Significant performance effects were observed on the test; self-assessment was more representative of actual ability, however, than of the treatment situation. The results suggest that although experiencing uncontrollable failure may result in performance deficits, perception of ability may not be distorted.
SH-wave diffraction by an interfacial flaw in monoclinic bimaterials

Abstract A system of incident, reflected and transmitted plane SH-waves is diffracted by an interface flaw in two dissimilar linearly elastic anisotropic half-spaces. The half-space solids have single planes of material symmetry. These coincide, but the two sets of principal material axes in the common plane have arbitrary orientations with respect to each other and to the interface. Exact transient solutions show the effects of material properties and orientation. Increasing the degree of non-orthotropy causes the maximum and minimum shear wave speeds in each solid to deviate more from the isotropic limit. For a non-orthotropic/isotropic bimaterial, this also causes the dynamic stress intensity factor to decrease, and the factor always falls below the factor value arising for a homogeneous solid with properties identical to those of the isotropic constituent.
7S nerve growth factor is an insulin-like growth factor-binding protein protease.

Insulin-like growth factor (IGF)-binding protein (IGFBP) proteases modulate IGF action by cleaving IGFBPs into fragments with lower affinity to IGFs, thereby increasing the levels of free IGFs. We have previously documented that prostate-specific antigen (PSA), a serine protease of the kallikrein family, is an IGFBP-3 protease. In this study, we characterized the potential IGFBP proteolytic activity of nerve growth factor (NGF gamma-subunit), which shares high sequence homology with PSA. [125I]IGFBP-3 was cleaved by NGF (but not other kallikreins) at a 3-fold lower concentration than that of PSA, thus proving NGF to be a more potent IGFBP protease than PSA. NGF-generated, lower mol wt IGFBP-3 fragments, detected by immunoblotting and cross-linking to IGFs, had a lower affinity to IGFs than intact IGFBP-3. Unlike PSA, which cleaves primarily IGFBP-3 and -5, NGF also displayed potent proteolytic activity against IGFBP-4 and -6. These data suggest that NGF may be involved in the growth of cells by more than ...
Azo-functionalized silk as a biocompatible material for low power holography and nonlinear optics

Azobenzene modified silk, a biocompatible material suitable for applications in biomedicine is shown to display photo-effects such as optically induced birefringence, suitability as a holographic recording material and photoinduction of surface relief features.
Reflecting on “Project Katrina” and Developmentally Appropriate Practices: A Graduate Student's Perspective

This article describes the independent study project of a student who was a graduate assistant in a child development laboratory preschool when Hurricanes Katrina and Rita struck the Gulf Coast area. Through her experiences with “Project Katrina” she deepens her understanding of developmentally appropriate practices as she learns firsthand about the project approach and writing an article for publication in a professional journal.
Use of orthographic structure by deaf adults: Recognition of fingerspelled words

Deaf adults' access to English word structure was tested in a task requiring letter report for fingerspelled words, orthographically regular nonsense words (pseudowords), and orthographically irregular nonsense words (nonwords). Deaf subjects, like hearing subjects, were sensitive to orthographic structure as indicated by accuracy of letter report: Letters of words were reported most accurately, while letters of pseudowords were reported more accurately than letters of nonwords. Analysis of errors on letter reports revealed that deaf subjects tended to produce orthographically regular responses. These results provide clear evidence that deaf adults are able to make use of orthographic structure.
The astrophysics of Jupiter

We compare the properties of Jupiter with those of radio pulsars and find a number of parallels insofar as the magnetic field, energization, and radio emission properties (pulsed, coherent, and microstructured), as well as a number of important presumed differences such as the Io modulation. Now that we can directly explore Jupiter's magnetosphere (but are yet uncertain as to the exact source of its radio emissions) what we learn may help us understand pulsars and other inaccessible astrophysical objects.
Combustion synthesis of nitrides: mechanistic studies

Abstract Combustion synthesis (CS) is characterized by extremely high heating rates (up to 10 6 K/s) and temperatures (up to 4000 K), as well as short times of reaction completion (usually less than 1 s, sometimes even 10 −3 –10 −2 s). The above unique conditions lead to materials microstructure formation mechanisms that cannot be observed in the isothermal or quasi-isothermal cases. In turn, evolution of the reaction media microstructure influences characteristics (temperature, velocity) of the combustion wave. In this work, such microstructural effects are demonstrated on the examples of CS in different gas–solid systems (i.e., Si–N 2 , Al–N 2 , and Nb–N 2 ). It is shown that dilution of the reaction media by inert high surface area precursors with phase compositions similar to the CS product leads to a significant increase in combustion velocity in the Si–N system, while the temperature remains constant. Also, it is revealed that dispersion of the metal (Nb) particles in the preheating zone might be responsible for constancy of the combustion velocity as a function of the size of the initial reactants. Finally, a complex two-stage mechanism of AlN formation explains the non-monotonic shape of the temperature–time profile observed during CS in this system.
A Psychiatrist's Experience in a Primary Health Care Setting

Psychiatrists have, for years, offered consultation to their nonpsychiatrist colleagues in many settings and have worked with them in a variety of ways. The development of new programs in primary medical care offers new challenges and opportunities to the liaison psychiatrist. This paper describes the experience of a full-time psychiatrist in a hospital-based primary health care setting. Special problems are encountered in developing working relationships with patients, physicians, nurses, social workers, administrators, and other members of the health care team. Effective resolution of these problems makes it possible to offer comprehensive mental health services as an integral part of primary health care. This psychiatrist's role differs from other consultation-liaison functions by virtue of full-time economic, patient care, academic, geographic and administrative assimilation into the primary health care setting itself. It is suggested that this role is an effective way to bring supportive and educatio...
Long-Term Results of Retropubic Permanent125 Iodine Implantation of the Prostate for Clinically Localized Prostatic Cancer

AbstractPurpose: The historical series of retropubic prostate radioactive source implantation from the Memorial Sloan-Kettering Cancer Center has served as the framework for the current transperineal implant approaches used in the treatment of localized prostatic cancer. We report the final assessment of the 15-year outcome.Materials and Methods: Between March 1970 and December 1987, 1,078 patients with biopsy proved adenocarcinoma of the prostate were treated at our cancer center with permanent implantation of125 iodine via a retropubic approach. In addition, all patients underwent bilateral pelvic lymphadenectomy before implantation. The clinical stages of disease were B1 in 234 patients (22%), B2 in 472 (44%), B3 in 145 (14%) and C in 227 (20%). Of the patients 733 (68%) had pathologically negative lymph nodes, whereas 345 (32%) had positive lymph nodes at lymph node dissection. Median followup was 11 years.Results: Multivariate analysis identified nodal involvement, high grade disease, clinical stage ...
Divination—A New Perspective

T HE purpose of this paper is to suggest a new interpretation of certain kinds of magical practices, especially divination. First, however, I should perhaps explain briefly the motivation for undertaking this analysis. The initial impetus came from experimental investigations of the problem-solving activities of groups.' These experiments quite naturally involved the study and classification of ineffective problem-solving techniques, and it appeared that fresh insight into this whole matter might be gained through examining some "classic" cases of ineffective solutions to problems. Magic is, by definition and reputation, a notoriously ineffective method for attaining the specific ends its practitioners hope to achieve through its use. On the surface, at least, it would seem then that magical rituals are classic cases of poor solutions to problems, and for this reason should be of theoretical interest from the standpoint of research on human problem solving. Most, if not all, scientific analyses of magic presuppose that these rituals as a matter of fact do not lead to the desired results. If the carrying out of a magical rite is followed by the hoped for state of affairs, then this is to be explained on other grounds. Scientific observers, of course, employ the criteria furnished by modern science to judge the probable efficacy of magical activities as methods for producing the ends-in-view of magicians. One of the puzzles most theories of magic seek to resolve is why human beings cling so tenaciously to magic if it does not work. Many contemporary explanations of this puzzle make use of the concept "positive latent function," that is, that even though magic fails to achieve its "manifest" ends, except by accident or coincidence, it serves its practitioners and/or their society in other critically important ways. The position developed here is compatible with the viewpoint that magical rituals may be sustained by numerous latent functions. However, it conceivably could serve as a prophylaxis against the overelaboration of these functions; in any case, it could serve as a supplementary explanation of the phenomena. Put baldly, the thesis to be advanced here is that some practices which have been classified as magic may well be directly efficacious as techniques for attaining the ends envisaged by their practitioners. Perhaps the best way to render plausible this somewhat counter-intuitive proposition is to consider in some detail an actual magical rite as it has been described by a highly competent anthropologist.2
Continuous dopaminergic delivery to minimize motor complications in Parkinson’s disease

Motor fluctuations and dyskinesias are common sequelae of Parkinson's disease (PD) that may limit function and quality of life. With disease progression, striatal dopamine concentration becomes closely linked to plasma levodopa levels, which vary considerably with standard oral regimens. Exposure of striatal dopamine receptors to wildly fluctuating transmitter levels is thought to contribute to the development of dyskinesias and motor fluctuations. Continuous dopaminergic delivery has been shown to reduce motor complications in advanced PD patients, and has been hypothesized to prevent their incidence when given as early therapy in mild PD. In this article, the authors outline the rationale for continuous dopaminergic delivery and review clinical strategies implementing the concept, including transdermal rotigotine, subcutaneous apomorphine infusion, intraduodenal infusion of levodopa gel and the investigational oral levodopa formulation IPX066.
C^k-quasi-isometry sets are pre-compact

Let M be a closed smooth manifold. By an argument formally similar to one used in constructing the Levi-Civita connection, it is shown that C k -quasi-isometry sets in DIF F k+1 (M) are C k+1 -bounded, where 0 ≤ k < ∞. This implies, using the Arsela-Ascoli theorem, that such sets are pre-compact in DIFF k (M).
Methodological frameworks for the geography of organizations

Abstract In this paper, we present three methodological frameworks for the geographic study of organizations. These are situated within three meta-theoretical perspectives in human geography: spatial science, critical realism, and post-structuralism. Each framework offers a different theorization of organizations, and each prompts different research questions that can be used to guide their geographic study. The research questions we offer are general, and are pertinent to all types of organizations. To supplement the methodological contributions of this paper, we suggest how each of these frameworks might inform empirical investigations of Appalshop, a media arts organization located in Whitesburg, Kentucky.
Health effects and optimal environmental taxes

Abstract The literature on environmental taxation in the presence of pre-existing distortionary taxes has shown that interactions with these distortions tend to raise the cost of an environmental tax, and thus that the optimal environmental tax is less than marginal environmental damages. A recent paper by Schwartz and Repetto (2000) challenges this finding, arguing that the health benefits from reduced pollution will also interact with pre-existing taxes, and may cause the optimal environmental tax to exceed marginal damages. Schwartz and Repetto’s analysis represented health effects implicitly in the utility function. In contrast, the present paper explicitly represents health effects in an analytically tractable general equilibrium model. This model shows that interactions with health effects from pollution actually will tend to reduce the optimal environmental tax, contradicting, Schwartz and Repetto’s conclusion. This demonstrates the usefulness of explicitly modeling health effects, and it reinforces the general notion that tax-interactions tend to raise the costs of an environmental tax.
Management strategy evaluation applied to the conservation of an endangered population subject to incidental take

Abstract Management strategy evaluation (MSE) is a simulation method commonly used to evaluate the expected performance of harvest strategies with respect to target populations. However, MSE is also useful for evaluating strategies designed to manage incidental take from endangered populations. We adapted MSE to the case of Sacramento River winter Chinook salmon, an endangered population that is subject to incidental take by mixed-stock ocean salmon fisheries that target more abundant stocks. Pursuant to the US Endangered Species Act, the US National Marine Fisheries Service called for a new fishery management strategy that would link the allowable fishing mortality to the population’s risk of extinction. Our objective was to evaluate extinction risk under different harvest strategies. We simulated the dynamics of the salmon population and the management process simultaneously. The management process included harvest strategies that set allowable fishing mortality rates as a function of population size. Strategies that reduced fishing mortality rates in response to low estimates of population size resulted in lower extinction risk than strategies that set fishing mortality rates at current or historical levels. The number of years of data taken into account by a strategy and the extent of reductions in fishing mortality resulted in different frequencies and durations of reduced fishing opportunity. By quantifying the trade-off between the risk of extinction of an endangered population and the opportunity for fisheries to harvest target stocks, our study illustrated the utility of MSE for applications to endangered populations.
Recycling of dissolved plasma membrane components as an explanation of the capping phenomenon.

IN a recent paper in Nature, Bretscher1 proposed that the capping phenomenon2,3 is caused by a continuous, directional flow of the lipid components of the plasma membrane across the cell surface from one end to the other, while the membrane proteins remain dispersed by random thermal motion and therefore do not normally participate. Bretscher's explanation of capping is that the cross linking of membrane proteins by attached antibodies and lectins causes them to be swept along by this lipid current and collected at the “uroid” portion of the cell surface, where he proposes that the membrane lipid is taken into the cytoplasm (by way of a “molecular filter”) for return to the opposite side of the cell as cytoplasmic vesicles. In this way Bretscher can account for the selective accumulation into caps of certain classes of surface antigen, without needing to postulate any communication between the surface and the interior. Cross-linked antigens would simply be swept into caps by the lipid current, while uncross-linked antigens would remain dispersed, just as is actually observed.
The Stabilities of N-Cl Bonds in Biocidal Materials.

N-halamine chemistry has been a research topic of considerable importance in these laboratories for over two decades. N-halamine compounds are useful in preparing biocidal materials. There are three N−Cl moieties available in cyclic N-halamine compounds: imide, amide, and amine. The stabilities toward the release of free halogen have been experimentally shown to decrease in the order amine > amide > imide. In this work, this generalization has been tested theoretically at the level of B3LYP/6-31+G(d) and using the conductor-like polarizable continuum aqueous solvation model with UAKS cavities. Excellent accord was observed between theory and experiment. It was also found that the imide and amide N-halamine stabilities on hydantoin rings could be reversed with substitution patterns at the 5 position.
Adenovirus E1b-58kd tumor antigen and SV40 large tumor antigen are physically associated with the same 54 kd cellular protein in transformed cells

The adenovirus E1b-58kd tumor antigen has been detected in a physical association with a 54 kilodalton cellular protein in adenovirus-transformed mouse cells. Antibody specific for the E1b-58kd protein coimmunoprecipitates a 54 kd protein from transformed, but not from productively infected, cells. Monoclonal antibody specific for the cellular 54 kd protein coimmunoprecipitates the adenovirus E1b-58kd protein from transformed cell extracts. The same or closely related cellular 54 kd protein, associated with the adenovirus E1b-58kd protein, was present in the SV40 large T antigen-54 kd complex previously detected in SV40-transformed mouse cells. The identity of the 54 kd protein is based on the immunological specificities of the anti-54 kd monoclonal antibodies and partial peptide maps of the 54 kd protein associated with the adenovirus and SV40 tumor antigens. The adenovirus E1b-58kd-54 kd complex, like the SV40 large T antigen-54 kd complex, is heterogeneous in size or mass. While all of the cellular 54 kd protein in the adenovirus-transformed cell extract is found in a complex with the E1b-58kd protein, some of the viral 58 kd antigen is detected in a form not associated with the 54 kd protein. The fact that the adenovirus and Sv40 tumor antigens, both required for transformation, can be found in physical association with the same cellular protein in a transformed cell is a good indication that these two diverse viral proteins share some common mechanisms or functions.