cssi/SciSciGPT-SciSciNet huggingface dataset:
Rational design and synthesis of polythioureas as capacitor dielectrics

Rational strategies combining computational and experimental procedures accelerate the process of designing and predicting properties of new materials for a specific application. Here, a systematic study is presented on polythioureas for high energy density capacitor applications combining a newly developed modelling strategy with synthesis and processing. Synthesis was guided by implementation of a high throughput hierarchical modelling with combinatorial exploration and successive screening, followed by an evolutionary structure search based on density functional theory (DFT). Crystalline structures of polymer films were found to be in agreement with DFT predicted results. Dielectric constants of ∼4.5 and energy densities of ∼10 J cm−3 were achieved in accordance with Weibull characteristic breakdown fields of ∼700 MV m−1. The variation of polymer backbone using aromatic, aliphatic and oligoether segments allowed for tuning dielectric properties through introduction of additional permanent dipoles, conjugation, and better control of morphology.
Capturing Trust in Social Web Applications

The Social Web constitutes a shift in information flow from the traditional Web. Previously, content was provided by the owners of a website, for consumption by the end-user. Nowadays, these websites are being replaced by Social Web applications which are frameworks for the publication of user-provided content. Traditionally, Web content could be ‘trusted’ to some extent based on the site it originated from. Algorithms such as Google’s PageRank were (and still are) used to compute the importance of a website, based on analysis of underlying link topology. In the Social Web, analysis of link topology merely tells us about the importance of the information framework which hosts the content. Consumers of information still need to know about the importance/reliability of the content they are reading, and therefore about the reliability of the producers of that content. Research into trust and reputation of the producers of information in the Social Web is still very much in its infancy. Every day, people are forced to make trusting decisions about strangers on the Web based on a very limited amount of information. For example, purchasing a product from an eBay seller with a ‘reputation’ of 99%, downloading a file from a peer-to-peer application such as Bit-Torrent, or allowing Amazon.com tell you what products you will like. Even something as simple as reading comments on a Web-blog requires the consumer to make a trusting decision about the quality of that information. In all of these example cases, and indeed throughout the Social Web, there is a pressing demand for increased information upon which we can make trusting decisions. This chapter examines the diversity of sources from which trust information can be harnessed within Social Web applications and discusses a high level classification of those sources. Three different techniques for harnessing and using trust from a range of sources are presented. These techniques are deployed in two sample Social Web applications—a recommender system and an online auction. In all cases, it is shown that harnessing an increased amount of information upon which to make trust decisions greatly enhances the user experience with the Social Web application.
A new stereoselective synthesis of (Z)-vinylsilane allylic alcohols

Abstract A new, highly stereoselective method for the synthesis of (Z)-vinylsilane allylic alcohols 3 is described. This approach to such γ-silylated allylic alcohols employs a novel 1,4-0→sp2C silyl rearrangement of appropriate silyl ether precursors 2 .
Nuclear War and Its Consequences on Television News

Because the threat of nuclear war is potentially too politically divisive and too frightening to the audience to be “newsworthy,” television may be a “silent, willing partner of government in keeping nuclear issues below the threshold of national consciousness.”
Daptomycin Experience in Critical Care Patients: Results from a Registry

Background:Vancomycin is often the drug of choice in critically ill patients with gram-positive infections, although circumstances often prevent its use. In these situations, clinicians are frequently left with limited data regarding alternative agents.Objective:To describe patients with reported sepsis receiving daptomycin in a critical care unit.Methods:This multicenter, noncomparative, noninterventional study identified patients in critical care units, using the Cubicin Outcomes Registry and Experience (CORE) 2005-2009 registry. A descriptive account of patient characteristics, infectious etiology, outcomes at the end of daptomycin therapy, and 30-day mortality is reported. Nonevaluable patients were excluded from the efficacy analysis but included in the safety analysis.Results:We identified 128 patients, 98 (77%) of whom were evaluable for efficacy. Patient characteristics for the efficacy population were 55 (56%) males, 30 (31%) aged 66 years or older, 38 (39%) had creatinine clearance less than 30 ...
Orthopaedic in-training examination: an analysis of the sports medicine section.

Background: Since 1963, the Orthopaedic In-Training Examination (OITE) has been administered to orthopaedic residents to assess resident knowledge and measure the quality of teaching within individual programs. The OITE has evolved dramatically over the years and now maintains a standardized format consisting of 275 questions divided among 12 sections.Purpose: To provide a detailed analysis of the OITE sports medicine section to identify patterns in question content, recommended references, and resident performance.Study Design: Cross-sectional study.Methods: All OITE sports medicine questions from 2005 to 2009 were analyzed, and the following data were recorded: resident performance scores, tested topics, type of imaging modalities, tested treatment modalities, taxonomy classification, and recommended references.Results: From 2005 to 2009, the sports medicine section composed 7.8% of the OITE. Mean resident performance on the entire OITE as well as on the sports medicine section improved during each year...
Towards a Dramaturgy of Robots and Object-Figures

Robotic and virtual figures have become increasingly visible in live performance. How these figures/performative agents come into the discussion of dramaturgy is considered in reference to recent works by Hirata Oriza and Kris Verdonck.
Compact physical IR-drop models for GSI power distribution networks

The supply voltage decrease and power density increase of future GSI chips demands accurate models for the IR-drop voltage. Compact physical IR-drop models are derived for two types of packages. These models help designers estimate the required amount of interconnects and package pins which need to be dedicated for power distribution. Comparison with SPICE simulations show less than 1% and 5% error for the wire-bond package and the area-array package, respectively.
Expanding the role of blood progenitor cells

Summary Five years ago the haemopoietic growth factors were introduced to clinical practice with the aim of reducing the depth and duration of chemotherapy induced neutropenia. Now, they have a wider remit, with important roles in supporting dose intensive treatments and mobilising BPC. Similarly, BPC themselves have until now been predominantly used in autologous transplantation following myeloablative treatments. In the next five years we can expect to see BPC from novel sources manipulated to feature in many new roles, including allogeneic transplantation, multicyclic dose-intensive chemotherapy and gene therapy
Parent and Child Independent Report of Emotional Responses to Asthma-Specific Vignettes: The Relationship Between Emotional States, Self-Management Behaviors, and Symptoms

Purpose Little is known about the emotional intelligence (EI) of parents and their children with asthma. Objectives of this study were to assess: 1) parent's and children's report of emotions in response to an asthma vignette (proxy for EI) and 2) the relationship between emotions, self-management behaviors, and symptoms. Design and Methods We conducted a descriptive, mixed methods study of children 7–12 years old with asthma. Parent–Child dyads (n=104) responded to an asthma vignette to gain insight into emotions, symptoms, and self-management behaviors. Additional questions assessed confidence and worry using a 5-point Likert scale. Thematic analyses and descriptive statistics were used to assess qualitative and quantitative outcomes. Results Children were predominantly male (58%), 7–9 (58%), and White (46%). The most common negative emotions reported by children were scared and sad . Children who sought help from an adult were less likely to report using medications compared to children who did not seek help (39.5% vs. 62.3%, p=.029). Children with low worry and high confidence had fewer symptoms compared to children reporting high worry and low confidence (symptoms: days 3.24 vs. 6.77, p=.012, nights 2.71 vs. 5.36, p=.004). Conclusions Children provided appropriate emotional responses to the asthma vignette; emotions were related to self-management behaviors and symptoms. More studies are needed to specifically assess EI in this population. Practice Implications Parents and children with greater EI may be better able to understand their needs, engage in self-management behaviors, and communicate with their nurses, to improve their support network and ability to access services.
Using red blood cell genomics in transfusion medicine

Blood types (blood group antigens) are heritable polymorphic antigenic molecules on the surface of blood cells. These were amongst the first human Mendelian traits identified, and the genetic basis of nearly all of the hundreds of blood types is known. Clinical laboratory methods have proven useful to identify selected blood group gene variants, and use of genetic blood type information is becoming widespread. However, the breadth and complexity of clinically relevant blood group genetic variation poses challenges. With recent advances in next-generation sequencing technologies, a more comprehensive DNA sequence-based genetic blood typing approach is now feasible. This chapter introduces the practitioner to high-resolution genetic blood typing beginning with an overview of the genetics of blood group antigens, the clinical problem of allosensitization, current blood type testing methods, and then discussion of next-generation sequencing and its application to the problem of genetic blood typing.
Representation of Linear Viscoelastic Behavior by Series-Parallel Models

In the preceding chapter we have treated the formal aspects of the impulse, step, slope, and harmonic responses but have said nothing about the actual form of the response. In this chapter and in Chap. 5 we will discuss the representation of viscoelastic behavior by mechanical, or, more precisely, rheological models.
Attempts to Demonstrate Poliomyelitis Virus in Extraneural Tissues.

ConclusionsThe technic described, while similar to that used with fair results for the isolation of the virus from stools and naso-pharyngeal washings,1 failed to detect the agent in extraneural tissues of poliomyelitis patients. Lennette14 has suggested that the virus may be present outside the CNS, but unidentifiable because of an attachment with antibody. Definite conclusions regarding the presence or absence of virus in extraneural tissues must await the development of more precise methods.
Mend It, Don't End It: The Case for Retaining the Disinterestedness Requirement for Debtor in Possession's Professionals

The National Bankruptcy Review Commission initially recommended the repeal of the so-called "disinterestedness" requirement for a debtor in possession's professionals. In the end, however, the Commission reconsidered its initial recommendation and instead chose to maintain the current standard with some minor, but important, revisions. This article argues that the Commission was correct to retain disinterestedness generally, but to modify it in certain circumstances. In particular, this article argues that the advocates of repealing disinterestedness have failed to demonstrate why disinterestedness should be retained for trustees, but not debtors in possession. The fundamental concerns in both cases are identical: preservation of the integrity of the bankruptcy system, preservation of public confidence in the bankruptcy system, and consistency with state ethical standards. The arguments for distinguishing professionals representing debtors in possession from those representing trustees are demonstrated as being flawed. [Note: The article is followed by comments on main paper by Charles W. Wolfram and Gerald K. Smith. A brief response to those comments is also presented; see Todd J. Zywicki, "Of Bubbling Pots and Bankruptcy Ethics: A Comment on Wolfram & Smith."]
A software system of CBM economic evaluation developed on ADO Technology

The work principle and object model of ADO technology is introduced with a case study.It is also introduced the application of ADO technology used in system of CBM economic evaluation.
Studying on an Article Style Which Petitioned to the Emperor -Since the 1980s

An article style which petitioned to the emperor is a kind of official document which was transmit to higher authorities in ancient times, and was generally called a kind document which minister reported to the emperor. The kind of article was flourishing and developing greatly in Tang dynasty. For its characteristics itself, the kind of article has great society function and culture meaning, but the academic community does not pay close attention to it since 1980s, some dissertations and monographs concerning it were published continually. Since 1990s, this studying developed more deeply, especially according with Tang dynasty. Now we coordinated these dissertation and monograph according to studying order and studying article.
Fluid resuscitation: the target from an analysis of trauma systems and patient survival.

Much can be learned from studying the deaths that occur in trauma systems as they have developed. Understanding these deaths and the potential effect of trauma systems on reducing death has major implications for designing clinical trials in fluid resuscitation. The availability of new, exciting information regarding fluid composition and physiologic effects argues for new, better-designed clinical trials. By agreeing on the form of resuscitation trials in the future, we will increase our ability to see clinically significant differences ii outcome as we move from animal data ti clinical efficacy.
Semi-automated quantification of C9orf72 expansion size reveals inverse correlation between hexanucleotide repeat number and disease duration in frontotemporal degeneration

We investigated whether chromosome 9 open reading frame 72 hexanucleotide repeat expansion (C9orf72 expansion) size in peripheral DNA was associated with clinical differences in frontotemporal degeneration (FTD) and amyotrophic lateral sclerosis (ALS) linked to C9orf72 repeat expansion mutations. A novel quantification workflow was developed to measure C9orf72 expansion size by Southern blot densitometry in a cross-sectional cohort of C9orf72 expansion carriers with FTD (n = 39), ALS (n = 33), both (n = 35), or who are unaffected (n = 21). Multivariate linear regressions were performed to assess whether C9orf72 expansion size from peripheral DNA was associated with clinical phenotype, age of disease onset, disease duration and age at death. Mode values of C9orf72 expansion size were significantly shorter in FTD compared to ALS (p = 0.0001) but were not associated with age at onset in either FTD or ALS. A multivariate regression model correcting for patient’s age at DNA collection and disease phenotype revealed that C9orf72 expansion size is significantly associated with shorter disease duration (p = 0.0107) for individuals with FTD, but not with ALS. Despite considerable somatic instability of the C9orf72 expansion, semi-automated expansion size measurements demonstrated an inverse relationship between C9orf72 expansion size and disease duration in patients with FTD. Our finding suggests that C9orf72 repeat size may be a molecular disease modifier in FTD linked to hexanucleotide repeat expansion.
Interleukin-31 pathway and its role in atopic dermatitis: a systematic review

AbstractBackground: Atopic dermatitis, a chronic inflammatory disease, has a lifetime prevalence of 10–20%. Atopic dermatitis reduces quality of life, primarily due to pruritus. Interleukin-31 and its target receptor are newly discovered entities that are involved in pruritus.Purpose: To summarize the current understanding of interleukin-31 and its role in atopic dermatitis, potential therapeutic interventions and future prospects.Methods: A systematic review was designed to identify articles related to interleukin-31 and its role in pruritus. Predefined queries containing interleukin-31 and related key terms were searched with no past date restriction, through 31 August 2016, using MEDLINE, Cochrane Controlled Trials Register, ClinicalTrials.gov and the International Clinical Trials Registry Platform Search Portal database.Results: Of 151 identified articles, 61 met eligibility criteria. Interleukin-31 receptors are expressed constitutively on the surface of keratinocytes, eosinophils and small diameter ...
MARCKS ED Inhibits Fibrin Formation By Blocking Coagulation Protein Complex Assembly on Phosphatidylserine

Introduction: Prothrombinase is an essential enzyme of the coagulation cascade that is made up of a heterodimer of coagulation factor Xa and Va. The complex most readily forms in the presence of lipid membranes containing the anionic lipid phosphatidylserine. The phosphatidylserine lipid head groups provide a surface for the prothrombinase complex to assemble and significantly increase the enzyme9s turnover number. Here, we investigate how truncation and modification of the naturally occurring myristoylated alanine-rich C-kinase substrate (MARCKS) protein into small peptide and peptidomimetic fragments (MARCKS ED) forms lipid probes that bind to phosphatidylserine, and block the assembly and enzymatic activity of the prothrombinase complex. Compared to known phosphatidylserine binding proteins such as annexin V or lactadherin, the MARCKS ED probes are less than a tenth of the molecular weight and do not require calcium to bind to phosphatidylserine. Methods: Using biophysical assays, we examine how the MARCKS ED probes assemble on lipid membranes containing phosphatidylserine and how this assembly alters the binding of factor Xa to these surfaces. Effects on the enzymatic activity of the prothrombinase complex in the presence of activated platelets and other phosphatidylserine exposing membranes are explored using a modified prothrombinase assay. The binding and anticoagulant activity of the MARCKS ED probes during whole blood coagulation are examined by quantifying fluorescently labeled MARCKS ED probe localization, platelet accumulation, and fibrin formation in microfluidic flow assays. Results: We find that the MARCKS ED probes can antagonize factor Xa from binding phosphatidylserine by measuring reduced association of factor Xa to lipid membranes treated with the MARCKS ED probes. Pre-treatment of activated platelets with the MARCKS ED probes significantly reduced the assembly and enzymatic activity of prothrombinase (100% activity with vehicle control vs. 51% with 1 μM MARCKS ED peptide treatment, P P Conclusions: We demonstrate that the MARCKS ED probes can inhibit the assembly and enzymatic activity of prothrombinase, and that this activity translates to significantly reduced fibrin formation in whole blood. The MARCKS ED peptide and peptidomimetic probes may provide a new therapeutic tool for inhibiting the assembly of phosphatidylserine dependent coagulation factors, as well as a research tool for identifying platelet phosphatidylserine exposure. Disclosures Kastelowitz: University of Colorado Boulder: Patents & Royalties. Yin: University of Colorado Boulder: Patents & Royalties.
College Football Bowl Games as Examples of Interorganizational Linkages within a Cultural Industry

Using the historical method through a historical institutionalism frame, this investigation examined interorganizational linkages established and supported by current and defunct Division I (Footba...
Abstract WP135: How to Get More From the NIH Stroke Scale

Introduction: Previous studies show that the NIH Stroke Scale (NIHSS) underestimates volume of right hemisphere (RH) relative to left hemisphere stroke. Hypothesis: Analysis of descriptions of the ...
Mental Health Collaboration: A Survey of Practicing School Psychologists.

ABSTRACTSchools have become the primary setting for mental health service among youth. However, school-based providers are sometimes limited by lack of time, training, and other resources. Furthermore, problem-solving models emphasize the importance of developing partnerships with other professionals and agencies. Thus, it is critical to engage in collaborative practice with non–school-based, community mental health providers (CMHPs). The purpose of this study was to survey practicing school psychologists about their experiences in communicating and collaborating with CMHPs. Participants (n = 194) indicated their frequency of communication and collaboration with CMHPs; although communication (i.e., release and receipt of information) was typical, fewer school psychologists reported engaging in ongoing collaboration. Benefits and barriers to collaboration were identified, and implications for practice are discussed.
Stereotype Threat, Erwartungseffekte und organisatorische Differenzierung: Schulische Leistungsbarrieren und Ansätze zu ihrer Überwindung

Die Vielfaltigkeit von Einwanderungsgesellschaften bringt neben vielen Chancen auch Herausforderungen mit sich. Eine der dringlichsten ist die effektive Bildung von Kindern mit einem so genannten ‚Migrationshintergrund‘. Weil Disparitaten in den Bildungserfolgen sozialer Gruppen verbreitet sind und gravierende Folgen haben, ist es unerlasslich zu verstehen, wie sie entstehen und uberwunden werden konnen. Dies gilt besonders, wenn das Leistungsgefalle zwischen Schulergruppen entlang der Trennlinie eines Migrationshintergrundes wie auch der Anteil der Bevolkerung mit Wanderungsgeschichte besonders hoch sind. Beides ist in Deutschland der Fall (vgl. oecd 2006).
Effect of drugs and illumination change on activity in the turtle

Under test conditions designed to maximize activity, marked reduction of locomotor and climbing movement in the fresh water turtle Chrysemys was observed following intraperitoneal administration of chlorpromazine. Control Ss, given saline or no pretreatment, produced significantly more activity when illumination was altered after 40 minutes than when light or darkness was continued for the 80-minute test period. Turtles given amphetamine sulphate, however, maintained a high level of activity regardless of illumination change. There was also a suggestion of complex interaction between the chlorpromazine effects and the test situation.
The termiticidal properties of superhydrophobic wood surfaces treated with ZnO nanorods

ZnO is a cost-effective and more environmentally friendly wood preservative than other metallic-based formulations. ZnO-stearate treatment imparts superhydrophobicity to wood surfaces, thereby providing triple protection to wood products, i.e., superhydrophobicity, inhibition to insects and microorganisms, and UV radiation protection. The objective of this study was to evaluate ZnO-stearate hydrophobic treatments of southern pine sapwood for resistance to Formosan subterranean termites. The data indicated that ZnO-stearate superhydrophobic treatment of southern pine wood samples received excellent mean visual ratings and mean weight loss values. The mean termite mortality was moderate. Unidentified fibril-like substances were found on the wood surfaces that were damaged by the termites.
Filmic representations of radicalization and terrorism: The silver screen as a catalyst for social science:

Recent years have seen increased attention to depictions of terrorism in film and, as a consequence, scholars have learned a great deal about why and how such films are made. Too often, however, wo...
Sphincterotomy/Sphincteroplasty for Papillary Dysfunction: Stenosing Papillitis

Simple division (5 mm) of the anterior surface of the sphincter of Oddi (sphincterotomy) was utilized in the mid 20th century for presumed biliary-pancreatic pain from sphincter of Oddi dysfunction (biliary dyskinesia). Lack of success led to a longer (2–3 cm) division of the sphincter with formal sphincteroplasty, but the improvement in outcome was only marginal. Most groups currently perform a generous sphincteroplasty with division of the transampullary septum to include division of the pancreatic component of the sphincter, and with this extended approach, have achieved good to excellent results in appropriately selected patients. This procedure allows free egress of bile and pancreatic juice into the duodenum after stimulation from ingestion of a meal. Stenting of the pancreatic duct of even the septotomy when needed can now be accomplished after endoscopic sphincteroplasty in experienced hands.
Origin of Scientific Method

We have emphasized that scientific method is a methodological approach to the process of inquiry – in which empirically grounded theory of nature is constructed and verified. To understand this statement, it is useful to go back in time to see how the method evolved. The origin of modern scientific method occurred in Europe in the 1600s: involving (1) a chain of research events from Copernicus to Newton, which resulted (2) in the gravitational model of the solar system, and (3) the theory of Newtonian physics to express the model.
Lentigo Maligna Pattern of Melanoma in Situ and Melanoma

Lentigo maligna is a pattern of melanoma in situ in severely sun damaged skin. Clinically, the lesion is found on chronically sun-exposed areas of the elderly and is a gradually enlarging brownish macule. Histologically, lentigo maligna is characterized by a long intrabasal growth phase, with inconsistent or no pagetoid spread. The evolution towards invasive melanoma is more frequently in the form of a spindle cell or desmoplastic melanoma than in other types. For all the above-mentioned distinctive features, lentigo maligna deserves to be treated separately from more common forms of melanoma in situ. It may prove to have genetic differences from other forms, reflecting a different pathogenesis.
Some Remarks on the L-Conjecture

In this paper, we show several connections between the L- conjecture, proposed by Burgisser [3], and the boundedness theorem for the torsion of elliptic curves. Assuming the L-conjecture, a sharper bound is obtained for the number of torsions over extensions of k on an elliptic curve over a number field k, which improves Masser's result [6]. It is also shown that the Torsion Theorem for elliptic curves [10] follows directly from the WL-conjecture, which is a much weaker version of the L-conjecture. Since the WL-conjecture differs from the trivial lower bound only at the coefficient, this result provides an interesting example where increasing the coefficient in a trivial lower bound of straight-line complexity is difficult and important.
Repolarization and activation restitution near human pulmonary veins and atrial fibrillation initiation: a mechanism for the initiation of atrial fibrillation by premature beats.

Objectives: The authors sought to study mechanisms to explain why single premature atrial complexes (PACs) from the pulmonary veins (PVs) may initiate human atrial fibrillation (AF).Background: The...
Short abstinence from online social networking sites reduces perceived stress, especially in excessive users

Online social networking sites (SNSs), such as Facebook, provide frequent and copious social reinforcers (e.g., "likes") delivered at variable time intervals. As a result, some SNS users display excessive, maladaptive behaviors on these platforms. Excessive SNS users, and typical users alike, are often aware of their intense use and psychological dependence on these sites, which may lead to elevated stress. In fact, research has demonstrated that use of SNSs alone induces elevated stress. Other research has begun to investigate the effects of short periods of SNS abstinence, revealing beneficial effects on subjective wellbeing. We aligned these two lines of research and hypothesized that a short period of SNS abstinence would induce a reduction in perceived stress, especially in excessive users. The results confirmed our hypothesis and revealed that both typical and excessive SNS users experienced reduction in perceived stress following SNS abstinence of several days. The effects were particularly pronounced in excessive SNS users. The reduction in stress was not associated with academic performance increases. These results indicate a benefit-at least temporarily-of abstinence from SNSs and provide important information for therapists treating patients who struggle with excessive SNS use.
Pressure ulcers: Pathophysiology, epidemiology, risk factors, and presentation.

Though preventable in most cases, pressure ulcers continue to pose a major burden to the individual and society, affecting ≤3 million adults annually in the United States alone. Despite increased national attention over the past 20 years, the prevalence of pressure ulcers has largely remained unchanged, while the associated costs of care continue to increase. Dermatologists can play a significant role in pressure ulcer prevention by becoming aware of at-risk populations and implementing suitable preventive strategies. Moreover, dermatologists should be able to recognize early changes that occur before skin breakdown and to properly identify and stage pressure ulcers to prevent delay of appropriate care. The aim of the first article in this continuing medical education series is to discuss the pathophysiology, risk factors, epidemiology, social and economic burdens, and clinical presentation of pressure ulcers.
Impacts of diffusion policy: determinants of early smart meter diffusion in the US electric power industry

Diffusion policies aid the adoption of technologies by targeting various channels of influence in an innovation system, including costs, learning, and standards. Little empirical research exists on their impacts, however, largely because of a lack of data. Using a panel dataset and econometric models, I analyze the determinants of the early diffusion of smart electricity meters in the US electric power industry, where public policy and regulation have supported the adoption of smart meters by electric utilities. The empirical findings suggest multiple drivers of smart meter diffusion. Policy and regulatory support have had a significant, positive impact on adoption, but the findings also suggest that utility characteristics and some combination of learning, cost reductions, and technology standards have been important determinants affecting smart meter diffusion. The timing, sequence, and context of diffusion policies are important to consider.
IEC 61850 Testing and Commissioning Advantages Using GOOSE Messaging

When a utility looks at implementing new changes with technology or their engineering and design standards, it is human nature to be resistant to these changes. This also holds true when a utility makes the transition from a conventional substation protection and control (P&C) system to a fully digital IEC 61850 based scheme. Existing testing procedures for conventional P&C schemes involves testing every element associated with that scheme. This often requires lengthy testing procedures and modifications to the relay setting. The modifications include assigning multiple protection elements, time overcurrent pickups, logic pickups, timers, and mapping elements to additional output contacts. When the transition from these conventional systems to IEC 61850 occurs, the question is raised “How am I going to test a protection or control scheme with no test switches to isolate the equipment?” This paper explores how IEC61850 can provide a more efficient testing and commissioning solution to the utility. It creates a more user-friendly interface with the equipment and an opportunity to provide a solution to existing problems. One of those opportunities that can be provided by IEC61850 utilizes GOOSE messages. The messages can be published from the devices for not only normal operation, but also contain data sets for testing purposes. By adding data sets for testing purposes, such as time overcurrent pick up (PTOC.Str) to the GOOSE message we eliminate the need for relay technicians to modify the relay settings. IEC61850 has built in testing capabilities directly and indirectly into the standard, this paper will examine how these implementation differences can be exploited.
FOXN3 hyperglycemic risk allele and insulin sensitivity in humans.

Objective The rs8004664 variation within the FOXN3 gene is significantly and independently associated with fasting blood glucose in humans. We have previously shown that the hyperglycemia risk allele (A) increases FOXN3 expression in primary human hepatocytes; over-expression of human FOXN3 in zebrafish liver increases fasting blood glucose; and heterozygous deletion of the zebrafish ortholog foxn3 decreases fasting blood glucose. Paralleling these model organism findings, we found that rs8004664 A|A homozygotes had blunted glucagon suppression during an oral glucose tolerance test. Here, we test associations between insulin sensitivity and the rs8004664 variation. Research design and methods 92 participants (49±13 years, body mass index: 32±6 kg/m2, 28 with and 64 without type 2 diabetes mellitus) were genotyped at rs8004664. Insulin sensitivity was measured by the euglycemic-hyperinsulinemic clamp technique. Results The “A” allele frequency was 59%; the protective (G) allele frequency was 41% (A|A: n=29; G|G: n=12; A|G: n=50). Clamp-measured glucose disposal rate (GDR) was not different by genotype (F=0.046, p=0.96) or by “A” allele carrier (p=0.36). Female G|G homozygotes had better insulin sensitivity compared to female “A” allele carriers (GDR; G|G: 9.9±3.0 vs A|A+A|G: 7.1±3.0 mg/kg fat-free mass+17.7/min; p=0.04). Insulin sensitivity was not different by genotype or by “A” allele carriers. Conclusion The rs8004664 variation within the FOXN3 gene may modulate insulin sensitivity in women.
CARDIOVASCULAR EVENTS ASSOCIATED WITH CAR-T THERAPY (ANALYSIS OF THE FDA ADVERSE EVENTS REPORTING SYSTEM)

Chimeric Antigen Receptor (CAR-T) cell therapy is approved in the US for treatment of Leukemias/Lymphomas. Multiple cardiovascular adverse events (CVAE) after CAR-T have been noted in small studies. We used the FDA adverse events reporting system (FAERS) to identify all reported adverse events (AEs
Correlation of high frequency QCM sphere-plate stiffness measurements with macroscopic frictional contacts in thin film and bulk stainless steel materials

Abstract We compare friction coefficient values μ for stainless steel contacts, obtained directly using a ball on disk tribometer and/or a basic “da Vinci” method, with values inferred from two microscale analysis methods reported in the literature that treat the response of a Quartz Crystal Microbalance (QCM) to rubbing contacts with one or more ball bearings. The microscale analysis methods both employ a Cattaneo-Mindlin slip scenario to relate contact stiffness to QCM response. Analysis Method 1 involves sweeps of the QCM amplitude of vibration while ball bearings are held in continuous contact with the oscillating electrode. It obtains μ from the slope of the associated frequency or bandwidth shift trace. We find that this method yields values for μ that compare favorably with macroscale values when the bandwidth dependence on vibrational amplitude is utilized. Method 2 obtains μ by analyzing the shifts in frequency and bandwidth that occur when ball bearings are brought in and out of contact with a QCM’s oscillating electrode at a fixed vibrational amplitude. We find that this method yields values for μ that compare favorably with macroscale values when the measurements are performed with a contact comprised of 3 close-packed ball bearings situated symmetrically about the center of the QCM electrode. Overall, the results validate the combination of assumptions employed in the analysis methods, and support the methods as a viable means for linkage of macro and nanoscale tribological measurements.
“Rape Is a Four-Letter Word“: Psychosis, Sexual Assault, and Abortion in the 2012 U.S. Election

Republican candidates made headlines during the 2012 election season for their offensive statements regarding rape when defending a comprehensive ban on abortion. Using Lacan’s theory of psychosis,...
Prolonged persistence of PCR-detectable virus during an outbreak of SARS-CoV-2 in an inpatient geriatric psychiatry unit in King County, Washington.

Background We describe key characteristics, interventions, and outcomes of a severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) outbreak within an inpatient geriatric psychiatry unit at the University of Washington Medical Center – Northwest. Methods After identifying 2 patients with SARS-CoV-2 infection on March 11, 2020, we conducted an outbreak investigation and employed targeted interventions including: screening of patients and staff; isolation and cohorting of confirmed cases; serial testing; and enhanced infection prevention measures. Results We identified 10 patients and 7 staff members with SARS-CoV-2 infection. Thirty percent of patients (n = 3) remained asymptomatic over the course of infection. Among SARS-CoV-2 positive patients, fever (n = 5, 50%) and cough (n = 4, 40%) were the most common symptoms. Median duration of reverse transcription polymerase chain reaction (RT-PCR) positivity was 25.5 days (interquartile range [IQR] 22.8-41.8) among symptomatic patients and 22.0 days (IQR 19.5-25.5) among asymptomatic patients. Median initial (19.0, IQR 18.7-25.7 vs 21.7, IQR 20.7-25.6) and nadir (18.9, IQR 18.2-20.3 vs 19.8, IQR 17.0-20.7) cycle threshold values were similar across symptomatic and asymptomatic patients, respectively. Conclusions Asymptomatic infection was common in this cohort of hospitalized, elderly individuals despite similar duration of SARS-CoV-2 RT-PCR positivity and cycle threshold values among symptomatic and asymptomatic patients.
Histopathologic Characterization of Mogamulizumab-associated Rash.

Rash is one of the most common adverse events observed with mogamulizumab, an anti-C-C chemokine receptor 4 monoclonal antibody approved for previously treated mycosis fungoides (MF) and Sezary syndrome (SS). Given the nonspecific clinical presentations of this rash, histopathologic distinction from MF/SS is critical for informing clinical management. We performed a comprehensive characterization of the histopathologic findings in mogamulizumab-associated rash (MAR) with the integration of high-throughput sequencing of T-cell receptor (TCR) genes. Fifty-two biopsy specimens from 19 patients were evaluated retrospectively. Three major histologic reaction patterns were identified: spongiotic/psoriasiform dermatitis (33/52), interface dermatitis (11/52), and granulomatous dermatitis (8/52). Almost half of the specimens (21/52) showed at least 2 of these reaction patterns concurrently. Dermal eosinophils were not a consistent feature, being present in only half (27/52) of specimens and prominent in only 3. Features mimicking MF/SS, including lymphocyte exocytosis, lamellar fibroplasia, and adnexal involvement, were commonly seen but tended to be focal and mild. In 38/43 specimens with available immunohistochemistry, intraepidermal lymphocytes demonstrated a CD4:CD8 ratio ≤1 : 1. Low background levels of the patient's previously identified MF/SS-associated TCR sequence(s) were demonstrated in 20/46 specimens analyzed by high-throughput sequencing of TCR. We conclude that MAR may demonstrate diverse histologic features. Findings that may distinguish MAR from MF/SS include the inverted or normalized CD4:CD8 ratio within intraepidermal lymphocytes and demonstration of absent or nondominant levels of disease-associated TCR sequences. Correlation with the clinical findings and immunohistochemical and molecular characterization of the patient's MF/SS before mogamulizumab, when possible, may facilitate recognition of MAR.
Adult Emergence Agitation: A Veteran-Focused Narrative Review

Emergence agitation (EA) is a self-limited state of psychomotor excitement during awakening from general anesthesia. EA is confined to the emergence period as consciousness is restored, which sharply distinguishes it from other postoperative delirium states. Sporadic episodes of EA may become violent with the potential for harm to both patients and caregivers, but the long-term consequences of such events are not fully understood. Current literature on EA in adults is limited to small-scale studies with inconsistent nomenclature, variable time periods that define emergence, a host of different surgical populations, and conflicting diagnostic criteria. Therefore, true incidence rates and risk factors are unknown. In adult noncardiac surgery, the incidence of EA is approximately 19%. Limited data suggest that young adults undergoing otolaryngology operations with volatile anesthetic maintenance may be at the highest risk for EA. Currently suggested EA mechanisms are theoretical but might reflect underblunted sympathetic activation in response to various internal (eg, flashbacks or anxiety) or external (eg, surgical pain) stimuli as consciousness returns. Supplemental dexmedetomidine and ketamine may be utilized for EA prevention. Compared to the civilian population, military veterans may be more vulnerable to EA due to high rates of posttraumatic stress disorder (PTSD) manifesting as violent flashbacks; however, confirmatory data are limited. Nonetheless, expert military medical providers suggest that use of patient-centered rapport tactics, PTSD trigger identification and avoidance, and grounding measures may alleviate hyperactive emergence phenomena. Future research is needed to better characterize EA in veterans and validate prophylactic measures to optimize care for these patients. This narrative review provides readers with an important framework to distinguish EA from delirium. Furthermore, we summarize current knowledge of EA risk factors, mechanisms, and adult management strategies and specifically revisit them in the context of veteran perioperative health. The anesthesiology care team is ideally positioned to further explore EA and develop effective prevention and treatment protocols.
ISLAM, ETHNICITY, NATIONALISM, AND THE BURMESE ROHINGYA CRISIS

This article discusses the world’s most oppressed people, the Muslim Rohingya of Burma (Myanmar) through the lens of “state symbologies and critical juncture”. It further argues the amalgamation of Burmese-Buddhist ethno-nationalism and anti-Muslim hate speech have become elements of Burma’s state symbology and components. Colonialism established conditions in which ethno-religious conflict could develop through policies that destroyed the civic religious pluralism characteristic of pre-colonial states. Burmese Buddhist ethno-religious nationalism is responsible for a series of communal conflicts and state repression because it did not recognize Muslims and other minorities as full and equal participants in the post-colonial national project. Therefore, the cycles of violence and the complexities of inter-ethnic and inter-religious relations indicate that Burmese political culture has become increasingly violent and genocidal.
Socialites boosted but loners set back in a crowd

![Graphic][1] People's responses to social situations varies considerably according to their personality type. We span the spectrum from loners to social butterflies and everything in between. And the same is true of other animals. Depending on their lifestyle, they may either be stressed or
COVID-19 Fatality Rate Classification using Synthetic Minority Oversampling Technique (SMOTE) for Imbalance Class

SARS-Cov-2 is not to be introduced anymore. The global pandemic that originated more than a year ago in Wuhan, China has claimed thousands of lives. Since the arrival of this plague, face mask has become part of our dressing code. The focus of this study is to design, develop and evaluate a COVID-19 fatality rate classifier at the county level. The proposed model predicts fatality rate as low, moderate, or high. This will help government and decision makers to improve mitigation strategy and provide measures to reduce the spread of the disease. Tourists and travelers will also find the work useful in planning of trips. Dataset used in the experiment contained imbalanced fatality levels. Therefore, class imbalance was offset using SMOTE. Evaluation of the proposed model was based on precision, F1 score, accuracy, and ROC curve. Five learning algorithms were trained and evaluated. Experimental results showed the Bagging model has the best performance.
Recipient and surgical factors trigger severe primary graft dysfunction after heart transplant.

Background Primary graft dysfunction (PGD) is a major cause of early mortality following heart transplant (HT). The International Society for Heart and Lung Transplantation (ISHLT) subdivides PGD into 3 grades of increasing severity. Most studies have assessed risk factors for PGD without distinguishing between PGD severity grade. We sought to identify recipient, donor and surgical risk factors specifically associated with mild/moderate or severe PGD. Methods We identified 734 heart transplant recipients at our institution transplanted between January 1, 2012 and December 31, 2018. PGD was defined according to modified ISHLT criteria. Recipient, donor and surgical variables were analyzed by multinomial logistic regression with mild/moderate or severe PGD as the response. Variables significant in single variable modeling were subject to multivariable analysis via penalized logistic regression. Results PGD occurred in 24% of the cohort (n = 178) of whom 6% (n = 44) had severe PGD. One-year survival was reduced in recipients with severe PGD but not in those with mild or moderate PGD. Multivariable analysis identified 3 recipient factors: prior cardiac surgery, recipient treatment with ACEI/ARB/ARNI plus MRA, recipient treatment with amiodarone plus beta-blocker, and 3 surgical factors: longer ischemic time, more red blood cell transfusions, and more platelet transfusions, that were associated with severe PGD. We developed a clinical risk score, ABCE, which provided acceptable discrimination and calibration for severe PGD. Conclusions Risk factors for mild/moderate PGD were largely distinct from those for severe PGD, suggesting a differing pathophysiology involving several biological pathways. Further research into mechanisms underlying the development of PGD is urgently needed.
The Axillary Artery and Humeral Head in ATOS

Classic arterial thoracic outlet syndrome (ATOS) involves injury and often aneurysmal degeneration of the subclavian artery. There exists a less commonly encountered variant that involves injury to the third portion of the axillary artery (or adjacent branch artery) due to stresses exerted by the humeral head. This is typically seen in high performance athletes in sports with frequent and repetitive overhead movements, and the presenting symptoms are similar to that of the more commonly seen ATOS. Management involves intervention for distal emboli and vascular reconstruction of the axillary artery and/or ligation of the branch artery.