cssi/SciSciGPT-SciSciNet huggingface dataset:
Road profile reconstruction using connected vehicle responses and wavelet analysis

Abstract Practitioners analyze the elevation profile of a roadway to detect localized defects and to produce the international roughness index. The prevailing method of measuring road profiles uses a specially instrumented vehicle and trained technicians, which usually leads to a high cost and an insufficient measurement frequency. The recent availability of probe data from connected vehicles provides a method that is cost-effective, continuous, and covers the entire roadway network. However, no method currently exists that can reproduce the elevation profile from multi-resolution features of the vehicle inertial response signal. This research uses the wavelet decomposition of the vehicle inertial responses and a nonlinear autoregressive artificial neural network with exogenous inputs to reconstruct the elevation profile. The vehicle inertial responses are a function of both the vehicle suspension characteristics and its speed. Therefore, the authors normalized the vehicle response models by the traveling speed and then numerically solved their inertial response equations to simulate the vehicle dynamic responses. The results demonstrate that applying the artificial neural network to the wavelet decomposed inertial response signals provides an effective estimation of the road profile.
Combustion synthesis and photoelectrochemical characterization of gallium zinc oxynitrides

We report a rapid combustion synthesis method for producing band gap tunable gallium zinc oxynitrides, a material of interest for water splitting applications. By varying the ratio of zinc and gallium, we can tune the band gap from 2.22 to 2.8 eV. Furthermore, nitrogen can be incorporated up to nearly 50% via replacement of oxygen without the need for high temperatures or an additional ammonolysis step. X-ray photoelectron spectroscopy (XPS) and EDX analysis suggests a preferential segregation of Zn to the surface of the as-synthesized particles, though the surface Ga/Zn molar ratio in the as-synthesized particles is correlated with the Ga/Zn molar ratio of the precursor materials. Photoelectrochemical measurements show that the oxynitride powders are photoactive under both AM1.5 and visible-only (λ > 435 nm) irradiation. Hydrogen and oxygen were both evolved in half-reaction experiments under simulated AM1.5 irradiation without externally applied bias, although addition of an OER catalyst did not enhance the rate of oxygen formation, suggesting that intra- and interparticle recombination are significant.
Radicalized loyalties: becoming Muslim in the West

These two books about Muslims in France (and also Great Britain in the latter) do not offer anything drastically new on a grand theoretical scale, but they both provide keenly focused case studies ...
Macromolecule Translocation in a Nanopore: Center of Mass Drift-Diffusion over an Entropic Barrier

ABSTRACT Many fundamental biological processes involve moving macromolecules across membranes, through nanopores, in a process called translocation. Such motion is necessary for gene expression and regulation, tissue formation, and viral infection. Furthermore, in recent years nanopore technologies have been developed for single molecule detection of biological and synthetic macromolecules, which have been most notably employed in next generation DNA sequencing devices. Many successful theories have been established, which calculate the entropic barrier required to elongate a chain during translocation. However, these theories are at the level of the translocation coordinate (number of forward steps) and thus lack a clear connection to experiments and simulations. Furthermore, the proper diffusion coefficient for such a coordinate is unclear. In order to address these issues, we propose a center of mass (CM) theory for translocation. We start with the entropic barrier approach and show that the translocation coordinate is equivalent to the center of mass of the chain, providing a direct interpretation of previous theoretical studies. We thus recognize that the appropriate dynamics is given by CM diffusion, and calculate the appropriate diffusion constant (Rouse or Zimm) as the chain translocates. We illustrate our theoretical approach with a planar nanopore geometry and calculate some characteristic dynamical predictions. Our main result is the connection between the translocation coordinate and the chain CM, however, we also find that the translocation time is sped up by 1–2 orders of magnitude if hydrodynamic interactions are present. Our approach can be extended to include the details included in previous translocation theories. Most importantly this work provides a direct connection between theoretical approaches and experiments or simulations. SIGNIFICANCE Macromolecule motion through nanopores is critical for many biological processes, and has been recently employed for nucleic acid sequencing. Despite this, direct theoretical understandings of translocation are difficult to evaluate due to the introduction of the translocation coordinate. In this manuscript, we propose a theory for translocation written at the center of mass level of the polymer chain. This theoretical approach is more easily compared to experimental and simulation results, and additionally allows one to accurately account for hydrodynamic interactions on the macromolecule dynamics.
Predictors of dental care use, unmet dental care need, and barriers to unmet need among women: results from NHANES, 2011 to 2016

OBJECTIVES To examine socio-demographic and economic predictors of dental care access among women in the United States. METHODS A total of 52,493,940 women at the US national level aged 20-44 years were identified from the National Health and Nutrition Examination Survey, 2011 to 2016. Weighted multivariate logistic regression models were computed to identify predictors of dental care use, unmet dental-care need, and reported reasons for unmet need. RESULTS Young, Mexican-American, other minority race-ethnicities, less educated, and uninsured women were independently more likely to have never visited a dental clinic (P < 0.025). Mexican-Americanwomen with a poverty income ratio (PIR) <2.00 and less than excellent health status and those uninsured were independently more likely to have unmet dental need (P < 0.025). Women with PIR <1.00 and those uninsured were independently more likely to have an unmet need because of unaffordable cost (P < 0.0008) or lack of procedure coverage by insurance (P < 0.0008). Younger women were more likely to think that the dental problem would go away (P < 0.0001). CONCLUSIONS While young, less educated, and women from minority race-ethnicities were less likely to report ever use of dental care, only low income, poor health, and uninsured women were more likely to report unmet dental care need. Racial-ethnic minority, less educated, and young women may benefit from improved education about the value of dental care. Expanding insurance coverage for dental care and improving access for women with poor health may address racial-ethnic and education-level disparities in unmet dental care need.
Demonstration of the Cybersecurity Framework through Real-World Cyber Attack

The Cybersecurity Framework (CSF) developed by the National Institute of Standards and Technology Cybersecurity, provides five concurrent and continuous functions to Identify, Protect, Detect, Respond, and Recover from cyber threats and vulnerabilities to buildings. Based on the core architecture and security best practices defined in the CSF guidelines, we developed the CSF webtools. The CSF webtools provide actionable functions that can be easily adopted by a facility operator to enhance their critical infrastructure security. The essence is captured in a set of “how-to” instructions for the facility operators to adopt, adapt, and apply to their critical infrastructure facilities. When considered together, these functions provide a high-level, strategic view of the lifecycle of an organization's cybersecurity risk management. The CSF webtools provide an easy to follow set of cybersecurity best practices, policies, and procedures to improve the cybersecurity posture of our nation's buildings and other critical infrastructures. The CSF webtools are also designed to facilitate communication of cybersecurity activities and outcomes across the organization from the executive to operations levels. Finally, the CSF webtools allow the critical infrastructure operators to assess the overall cybersecurity maturity and posture. The goal of this paper is to demonstrate the capabilities of the CSF webtools through an illustrative cyber-attack based on a real-world scenario.
What Are 3GPP 5G Phase 1 and 2 and What Comes After

This paper describes the ongoing standardization of the new 5G system and the planned next steps in the 3rd Generation Partnership Project (3GPP) groups. Starting with an overview of how 3GPP works, what is meant with 5G Phase 1 and 2 and a clear timeline for ongoing and planned activities are provided. Finally an interesting innovation vector for beyond 5G systems, i.e. dynamic (in time) spectrum management, is briefly mentioned.
Underdiagnosis of obesity in pediatric clinical care settings among children born preterm: a retrospective cohort study.

Background Neonatal care of preterm infants may include dietary approaches such as high calorie formulas to promote physical growth. However, continuing growth-promoting strategies beyond the point of necessity, coupled with poverty and food insecurity which are more common among families of children born preterm, may increase the risk of obesity. Because children born preterm tend to have more pressing health conditions that require ongoing care, obesity may go undiagnosed by providers. Methods This retrospective cohort study included 38,849 children (31,548 term, 7301 preterm) born from 2010 to 2015, who received clinical care at a large pediatric medical center (Ohio, USA). Electronic medical record data, linked to Ohio birth certificates, were used to identify children with measured obesity (≥2 weight-for-length values ≥95th percentile before 24 months of age or BMI values ≥95th percentile at or after 24 months of age). Children were considered to have diagnosed obesity if their medical record had an obesity-related phrase or billing code recorded. Modified Poisson regression was used to compare risk of obesity undiagnosis among obese children born preterm versus at term. Results In total, 13,697 children had measured obesity, 10,273 (75%) of which were undiagnosed. Children born preterm with measured obesity were 8% more likely to be undiagnosed compared to children born at term (adjusted relative risk = 1.08 95% CI 1.05, 1.11). The risk was slightly higher for preterm children born to white women or born to women with higher educational attainment. For both groups, Primary Care and subspecialist clinics were the most common settings for undiagnosed obesity (74.9% and 16.8% of undiagnosed cases, respectively). Conclusions and relevance Preterm birth was associated with increased risk of undiagnosed obesity in early childhood. This highlights the need to enhance obesity screening in the preterm population and to further explore reasons for this disparity.
Artificial Learning and Machine Learning Decision Guidance Applications in Total Hip and Knee Arthroplasty: A Systematic Review.

Background Artificial intelligence (AI) and machine learning (ML) modeling in hip and knee arthroplasty (total joint arthroplasty [TJA]) is becoming more commonplace. This systematic review aims to quantify the accuracy of current AI- and ML-based application for cognitive support and decision-making in TJA. Methods A comprehensive search of publications was conducted through the EMBASE, Medline, and PubMed databases using relevant keywords to maximize the sensitivity of the search. No limits were placed on level of evidence or timing of the study. Findings were reported according to the PRISMA (Preferred Reporting Items for Systematic Reviews and Meta-Analyses) guidelines. Analysis of variance testing with post-hoc Tukey test was applied to compare the area under the curve (AUC) of the models. Results After application of inclusion and exclusion criteria, 49 studies were included in this review. The application of AI/ML-based models and average AUC is as follows: cost prediction-0.77, LOS and discharges-0.78, readmissions and reoperations-0.66, preoperative patient selection/planning-0.79, adverse events and other postoperative complications-0.84, postoperative pain-0.83, postoperative patient-reported outcomes measures and functional outcome-0.81. Significant variability in model AUC across the different decision support applications was found (P < .001) with the AUC for readmission and reoperation models being significantly lower than that of the other decision support categories. Conclusions AI/ML-based applications in TJA continue to expand and have the potential to optimize patient selection and accurately predict postoperative outcomes, complications, and associated costs. On average, the AI/ML models performed best in predicting postoperative complications, pain, and patient-reported outcomes and were less accurate in predicting hospital readmissions and reoperations.
Interdisciplinary Management of Malignant Ovarian Tumors in the Pediatric and Adolescent Age Group

Abstract Malignant ovarian neoplasms are uncommon in the pediatric and adolescent population. Imaging and tumor markers help to guide the preoperative risk/benefit analysis for planned surgical management, which is the mainstay of therapy. An interdisciplinary approach should be taken in the management of this vulnerable population from diagnosis through post-treatment surveillance. In this review, the initial evaluation, risk stratification, and management of various types of malignant ovarian masses will be addressed with a special focus on how to optimize an interdisciplinary approach to ovarian masses.
Metabolic regulation in model ascomycetes – adjusting similar genomes to different lifestyles

The related yeasts Saccharomyces cerevisiae and Candida albicans have similar genomes but very different lifestyles. These fungi have modified transcriptional and post-translational regulatory processes to adapt their similar genomes to the distinct biological requirements of the two yeasts. We review recent findings comparing the differences between these species, highlighting how they have achieved specialized metabolic capacities tailored to their lifestyles despite sharing similar genomes. Studying this transcriptional and post-transcriptional rewiring may improve our ability to interpret phenotype from genotype.
Storage Ring Laser Spectroscopy

Publisher Summary This chapter focuses on storage ring laser spectroscopy. The advent of heavy-ion cooler rings has created a rapidly growing new field of laser spectroscopy. There are a number of unique possibilities accessible for laser-based experiments in heavy-ion storage rings. One centers on the physics in an electron cooler where stored ions and the electrons copropagate with nearly equal velocity and form an unusual kind of plasma. The analysis of this interaction by laser techniques can help to understand the cooling process in the storage ring and to examine the physics of highly charged plasmas. The technique used for these studies is laser-induced recombination, the reverse of resonant laser ionization. An interesting process in itself, it provides a selective population of very high-lying Rydberg states, which can be used as a starting point for precision laser spectroscopy in a second step. Another group of experiments seeks to use laser cooling in addition to electron cooling to reduce the thermal energy of the ions in the storage ring below the magnitude of the intrabeam Coulomb fields. Therefore, collective effects become important, which may finally lead to a transition to liquid behavior of the beam or even crystallization. The goal is to study ordering phenomena in the one component plasma formed by the stored beam.
Adaptive coding for high-rate direct-sequence spread spectrum

High-rate direct-sequence (DS) spread spectrum is a modulation technique in which most or all of the spreading is provided by nonbinary data modulation. For applications to mobile ad hoc wireless networks, the limited processing gain of high-rate DS spread spectrum gives only modest protection against multiple-access or multipath interference, but increased interference rejection capability can be obtained from error-control coding. In this paper, we evaluate the performance of high-rate DS spread spectrum with turbo product codes. The utility of the Gaussian approximation for the design of adaptive coding systems is illustrated. An adaptive coding algorithm is described and its performance is compared with that of fixed-rate codes for channels with unknown propagation loss. The algorithm is based on statistics obtained in the receiver, and no external side information is employed.
The state of manganese in the photosynthetic apparatus: 5. The chloride effect in photosynthetic oxygen evolution. Is halide coordinated to the EPR-active manganese in the O2-evolving complex? Studies of the substructure of the low-temperature multiline EPR signal

Abstract The role of chloride in the manganese-containing oxygen-evolving complex of Photosystem II has been studied by observing the amplitude of the multiline EPR signal as a function of Cl − concentration or when Cl − is replaced by Br − or F − . The correlation of the multiline EPR signal intensity and O 2 activity with the concentration of Cl − shows that chloride is involved in oxygen evolution at the S 2 or earlier S states, and that it is necessary for the production of an EPR-detectable S 2 state. We have developed a new method for the preparation of subchloroplast PS II particles containing Br − and F − ) and have used these particles for studying the EPR fine structure at high resolution. The fine structure shows a multiplet of 4–6 lines with 10–15 G spacing; at the resolution of our experiment there are no significant differences between the Cl − -and Br − -containing samples, suggesting that the halide is not a ligand of the EPR-active Mn. Various structural possibilities for the Mn complex, which would account for the observed fine structure of the multiline EPR spectrum are discussed.
Laboratory Maintenance of Flavobacterium psychrophilum and Flavobacterium columnare

Bacteria in the genus Flavobacterium are highly heterogeneous and are comprised of pathogenicandnon-pathogenicspecies.Theyarefoundinawidevarietyofenvironments that include fresh and marine water, soil, and ocean sediments. This unit focuses on laboratory maintenance of two important fish pathogens within this genus. Flavobacterium psychrophilum and F. columnare are fastidious, slow-growing organisms that require specialized medium for optimal growth in the laboratory. Methods are described for the preparationofmedia,brothandagarculture,cryopreservation,andenumerationofviable cells for these bacteria. In addition, the diseases caused by these pathogens are described along with methods of diagnosis and treatments. This unit serves as a general guide for the cultivation of F. psychrophilum and F. columnare and discusses some of the difficulties that have been encountered for each. Curr. Protoc. Microbiol. 6:13B.1.1-13B.1.12. C � 2007 by John Wiley & Sons, Inc.
Nail-Patella Syndrome: A Report of a Saudi Arab Family With an Autosomal Recessive Inheritance.

Background:Nail-patella syndrome (NPS) is an autosomal dominant disorder with a variable interfamilial and intrafamilial clinical expressivity and penetrance. It is caused by loss-of-function heterozygous mutation in the LIM-homeodomain transcription factor (LMX1B) located on chromosome 9q. The pleiotropic LMB1X gene, a member of the homeogene family, is involved in the development of glomerular basement membrane, dorsoventral limb structures, along with the nails and the anterior segment of the eye.Objective:Here, we report a Saudi Arab consanguineous family with 2 affected sisters presented with the typical nail changes of NPS.Methods:DNA samples were collected from the sisters and their parents after consent.Results:Both sisters were found to be homozygous for a previously described disease-causing mutation (c.268C>T) at the (LMX1B) gene. Both of the phenotypically normal parents were confirmed to be heterozygous for the same mutation.Conclusion:This finding supports the autosomal recessive mode of inh...
Bioelectric Regulation of Tentacle Movement in a Dinoflagellate

1. Recurring extensions and flexions of the food-gathering tentacle of Noctiluca miliaris occur spontaneously. Identical movements can be evoked by appropriate electrical stimulation. 2. Spontaneous recurring potential wave forms (TRPs) were recorded from the vacuole of the luminescent form of Noctiluca during movements of the tentacle. The basic TRP wave form consists of a characteristic negative-going spike which arises at -20 to -30 mV. from the slowly redeveloping negativity of a pre-spike depolarization, and is followed by a quasi-stable post-spike d.c. level of relative vacuolar negativity (-45 to -60 mV.). 3. The TRP complex, similar in shape to that which occurs spontaneously, follows an intracellularly applied current pulse of either polarity if the vacuolar potential is at the post-spike level. The duration of the evoked pre-spike wave is related to the current intensity and duration. During the pre-spike state outward current is ineffective, although a TR spike occurs in response to inward current. 4. The TRP is distinct in its behaviour and wave form from the flash-triggering potential, which can be evoked in the same cell, even though both exhibit all-or-none spikes. 5. Simultaneous recordings of intracellular potentials and movements of the tentacle showed a consistent temporal relationship between potential changes and subsequent movement. Extension of the tentacle begins 1-2 sec. after the spike and flexion begins within 1 sec. after beginning of the pre-spike wave. 6. Tentacle movement ceased in Ca-free sea water even though the cyclic potential changes continued normally. 7. Electron micrographs of the tentacle showed longitudinal aggregations of microtubules near the outer surface of the peripheral cytoplasm. It is proposed that contraction of these microtubules is the immediate cause of tentacle movements.
Protein Dynamics — Concepts and Experimental Tools

Most textbooks and publications show proteins in a unique structure and naked, without hydration shell and bulk environment. In reality, proteins can assume a very large number of different conformations. They fluctuate continuously and are controlled by the hydration shell and the solvent. Without these fluctuations, proteins could not work. This chapter gives a brief overview of protein dynamics and cites references where more information can be found. Keywords: conformational substates; energy landscape; α and β fluctuations; proteinquakes; slaving
String compactifications on Calabi-Yau stacks

Abstract In this paper we study string compactifications on Deligne–Mumford stacks. The basic idea is that all such stacks have presentations to which one can associate gauged sigma models, where the group gauged need be neither finite nor effectively-acting. Such presentations are not unique, and lead to physically distinct gauged sigma models; stacks classify universality classes of gauged sigma models, not gauged sigma models themselves. We begin by defining and justifying a notion of “Calabi–Yau stack”, recall how one defines sigma models on (presentations of) stacks, and calculate of physical properties of such sigma models, such as closed and open string spectra. We describe how the boundary states in the open string B model on a Calabi–Yau stack are counted by derived categories of coherent sheaves on the stack. Along the way, we describe numerous tests that IR physics is presentation-independent, justifying the claim that stacks classify universality classes. String orbifolds are one special case of these compactifications, a subject which has proven controversial in the past; however we resolve the objections to this description of which we are aware. In particular, we discuss the apparent mismatch between stack moduli and physical moduli, and how that discrepancy is resolved.
El Niño–Southern Oscillation Impacts on Winter Vegetable Production in Florida*

Abstract Florida’s mild winters allow the state to play a vital role in supplying fresh vegetables for U.S. consumers. Producers also benefit from premium prices when low temperatures prevent production in most of the country. This study characterizes the influence of the El Nino–Southern Oscillation (ENSO) on the Florida vegetable industry using statistical analysis of the response of historical crop (yield, prices, production, and value) and weather variables (freeze hazard, temperatures, rainfall, and solar radiation) to ENSO phase and its interaction with location and time of year. Annual mean yields showed little evidence of response to ENSO phase and its interaction with location. ENSO phase and season interacted to influence quarterly yields, prices, production, and value. Yields (tomato, bell pepper, sweet corn, and snap bean) were lower and prices (bell pepper and snap bean) were higher in El Nino than in neutral or La Nina winters. Production and value of tomatoes were higher in La Nina winters....
Membrane binding by prothrombin mediates its constrained presentation to prothrombinase for cleavage.

Long-standing dogma proposes a profound contribution of membrane binding by prothrombin in determining the rate at which it is converted to thrombin by prothrombinase. We have examined the action of prothrombinase on full-length prothrombin variants lacking γ-carboxyglutamate modifications (desGla) with impaired membrane binding. We show an unexpectedly modest decrease in the rate of thrombin formation for desGla prothrombin but with a major effect on the pathway for substrate cleavage. Using desGla prothrombin variants in which the individual cleavage sites have been singly rendered uncleavable, we find that loss of membrane binding and other Gla-dependent functions in the substrate leads to a decrease in the rate of cleavage at Arg320 and a surprising increase in the rate of cleavage at Arg271. These compensating effects arise from a loss in the membrane component of exosite-dependent tethering of substrate to prothrombinase and a relaxation in the constrained presentation of the individual cleavage sites for active site docking and catalysis. Loss of constraint is evident as a switch in the pathway for prothrombin cleavage and the intermediate produced but without the expected profound decrease in rate. Extension of these findings to the action of prothrombinase assembled on platelets and endothelial cells on fully carboxylated prothrombin reveals new mechanistic insights into function on physiological membranes. Cell-dependent enzyme function is probably governed by a differential ability to support prothrombin binding and the variable accumulation of intermediates from the two possible pathways of prothrombin activation. Background: Prothrombin variants lacking membrane binding have probed the contribution of the substrate-membrane interaction in thrombin formation by prothrombinase. Results: Loss of membrane binding yields modest changes in rate but affects the pathway for substrate cleavage. Conclusion: Membrane binding by the substrate constrains the presentation of prothrombin for cleavage by prothrombinase. Significance: New insights into how the action of prothrombinase on prothrombin is regulated.
Multiple redundant circadian oscillators within the isolated avian pineal gland

The avian pineal gland contains a circadian pacemaker that oscillates in vitro. Using a flow-through culture system it is possible to measure melatonin production from very small subsections of an individual gland. We have used this technique to attempt to localize the oscillators in the pineal. Progressive tissue reduction did not affect the rhythmicity of cultured pineals. Multiple pieces (up to eight) from a single pineal all were capable of circadian oscillation — establishing directly that a pineal gland contains at least eight oscillators. All pineal pieces were responsive to light, and single light pulses shifted the phase of the melatonin rhythm. Because pieces equivalent to less than one per cent of the whole gland were rhythmic and because the capacity for oscillation was distributed throughout the gland, an individual pineal appears to be composed of a population of circadian oscillators.
Gene Action in Relation to Growth and Development: I. Phenotypic Variability.

Among the most fundamental problems in biology belongs the action of the gene. The gene, however, is elusive since no direct approach is possible: the gene can only be recognized by its effect. These effects may be used either in their final expression - the heritable characters - and then we are in the domain of classical genetics. Or we can try to infer from the final and intermediate steps of gene action what lies at the beginning of this chain. This is the approach of both the biochemist, the embryologist, and the physiologist. The successes of the biochemist in approaching the action of the gene are spectacular, such as in the analysis of biosynthesis in Neurospora.
Calcium content of bacteriophage T2.

1. 1. The calcium content of preparations of bacteriophage T2 has been determined. Each T2 particle contains 130 ± 19 atoms of bound calcium; 40 of the calcium atoms are bound more strongly than the others. 2. 2. The calcium appears to be bound to the tail protein of the intact phage and is released when the tail protein contracts after interaction with host cell walls. 3. 3. There appears to be one calcium bound at each ATP binding site of the phage tail protein. It has been concluded that the calcium stimulates the hydrolysis of the ATP during the contraction of the phage tail protein during viral invasion.
Hippocampal CA1 apical neuropil atrophy and memory performance in Alzheimer's disease

Memory loss is often the first and most prominent symptom of Alzheimer's disease (AD), coinciding with the spread of neurofibrillary pathology from the entorhinal cortex (ERC) to the hippocampus. The apical dendrites of hippocampal CA1 pyramidal neurons, in the stratum radiatum/stratum lacunosum-moleculare (SRLM), are among the earliest targets of this pathology, and atrophy of the CA1-SRLM is apparent in postmortem tissue from patients with mild AD. We previously demonstrated that CA1-SRLM thinning is also apparent in vivo, using ultra-high field 7-Tesla (7T) MRI to obtain high-resolution hippocampal microstructural imaging. Here, we hypothesized that CA1-SRLM thickness would correlate with episodic memory performance among patients with mild AD. We scanned nine patients, using an oblique coronal T2-weighted sequence through the hippocampal body with an in-plane resolution of 220 μm, allowing direct visual identification of subfields - dentate gyrus (DG)/CA3, CA2, CA1, and ERC - and hippocampal strata - SRLM and stratum pyramidale (SP). We present a novel semi-automated method of measuring stratal width that correlated well with manual measurements. We performed multi-domain neuropsychological evaluations that included three tests of episodic memory, yielding composite scores for immediate recall, delayed recall, and delayed recognition memory. Strong correlations occurred between delayed recall performance and the widths of CA1-SRLM (r(2)=0.69; p=0.005), CA1-SP (r(2)=0.5; p=0.034), and ERC (r(2)=0.62; p=0.012). The correlation between CA1-SRLM width and delayed recall lateralized to the left hemisphere. DG/CA3 size did not correlate significantly with any aspect of memory performance. These findings highlight a role for 7T hippocampal microstructural imaging in revealing focal structural pathology that correlates with the central cognitive feature of AD.
Development of disjunctive reasoning and the use of MAYBE in fifth through eighth graders

Abstract Approximately one-half of the fifth through eighth graders in a school district ( n = 164) were randomly selected to be administered a group test of disjunctive reasoning containing 48 inclusive and exclusive items varying in content of the premises (symbolic, object, and human), and affirmation or negation of the conclusion. Using an analysis of variance for repeated measures it was found that performance improved until seventh grade. Eighth graders scored similar to sixth graders. There was a main effect for negative, with negative conclusions producing more correct answers. Further, there were significant first order interactions for Disjunctive by Negation, Content by Grade, and Negation by Content. Since either “YES” or “NO” were the only correct answers, and “MAYBE” was always wrong, contrast of the MAYBE responses to other wrong answers revealed an increasing tendency to use MAYBE among older subjects. Implications were discussed in relation to cognitive developmental theory and educational practices.
Preparation, characterization, and chemistry of solid ceramic breeder materials

A method is presented for the preparation of pure Li2O and LiAlO2 from Li2CO3. A method for quantitative estimation of LiOH as a contaminant in Li2O is also described, along with results for LiOH contamination in Li2O samples obtained from various sources. Limited results are presented on the effect of moisture content in a helium carrier gas on the volatility of Li2O. By means of gas-solid equilibration techniques, the apparent solubility of LiOH in Li2O has been estimated to be 0.003 wt %, at 1098 K, giving an estimated hydrogen concentration of 1 wppm.
A kaleidoscope of possibilities: strategies for assessing human capital in libraries

Purpose – The purpose of paper one of the two‐article series exploration of human capital assessment is to examine the strategies by which library administrators can assess and benefit the human capital performance of their library and to lay the groundwork for the discussion of the strategic challenges of assessing and valuing human capital in article two.Design/methodology/approach – This paper uses a literature review to identify potential strategies and metrics for library administrators to assess human capital productivity.Findings – Human capital is an increasingly essential element of organizational performance assessment. Effectively assessing library staff expenditures (which generally receives the largest expenditure allocations within the library's budget) and the resulting performance generated by the staff, who are the primary knowledge tools and providers of the library's services, is an ever increasing possibility to account for greater amounts of tangible and intangible organizational perf...
Two decades of exposure assessment studies on chromate production waste in Jersey City, New Jersey--what we have learned about exposure characterization and its value to public health and remediation.

During much of the twentieth century, Jersey City, New Jersey was the leading center of chromate production in the United States. Chromate production produced huge volumes of chromium ore-processing residue containing many parts per million of hexavalent chromium. Starting in the 1990s, we undertook a series of studies to identify exposed populations, sources and pathways of exposure and the effectiveness of remediation activities in Jersey City. These studies revealed the effectiveness and success of the remediation activities. The sequence of studies presented here, builds on the lessons learned from each preceding study and illustrates how these studies advanced the field of exposure science in important ways, including the use of household dust as a measure of exposure to contaminants originating in the outdoor environment; development of effective and reproducible dust sampling; use of household dust to track temporal changes in exposure; understanding of the spatial relationship between sources of passive outdoor particulate emissions and residential exposure; use of focused biomonitoring to assess exposure under conditions of large inter-individual variability; and utility of linking environmental monitoring and biomonitoring. For chromium, the studies have demonstrated the use of Cr+6-specific analytical methods for measuring low concentrations of Cr+6 in household dust and understanding of the occurrence of Cr+6 in the background residential environment. We strongly recommend that environmental and public health agencies evaluate sites for their potential for off-site exposure and apply these tools in cases with significant potential as appropriate. This approach is especially important when contamination is widespread and/or a large population is potentially exposed. In such cases, these tools should be used to identify, characterize and then reduce the exposure to the off-site as well as on-site population. Importantly, these tools can be used in a demonstrable and quantifiable manner to provide both clarity and closure to concerned stakeholders.
Managing Change in a Research University Special Education Program

In the following case study, we describe the discourse and external events preceding a change in the culture of the University of Washington Special Education program. Activities that followed were typical of a paradigm shift as described in the literature. The study concludes with evidence of intense collaborative activity followed by significant programmatic and curricular modification. We end with a vision of future program directions and descriptions of the type of personnel needed to implement our vision.
Long-Term Cardiovascular Outcomes In Patients With Angina Pectoris Presenting With Bundle Branch Block

Long-term outcomes of unselected patients with angina pectoris and bundle branch block (BBB) on initial electrocardiogram are not well established. The Olmsted County Chest Pain Study is a community-based cohort of 2,271 consecutive patients presenting to 3 Olmsted County emergency departments with angina from 1985 through 1992. Patients were followed for major adverse cardiovascular events (MACEs) including death, myocardial infarction, stroke, and revascularization at 30 days and over a median follow-up period of 7.3 years and for mortality only through a median of 16.6 years. Cox models were used to estimate associations between BBB and cardiovascular outcomes. Mean age of the cohort on presentation was 63 years, and 58% were men. MACEs at 30 days occurred in 11% with right BBB (RBBB), 8.8% with left BBB (LBBB), and 6.4% in patients without BBB (p = 0.17). Over a median follow-up of 7.3 years, patients with BBB were at higher risk for MACEs (RBBB, hazard ratio [HR] 1.85, 95% confidence interval [CI] 1.44 to 2.38, p <0.001; LBBB, HR 2.04, 95% CI 1.62 to 2.56, p <0.001) compared to those without BBB. Over a median of 16.6 years, the 2 BBB groups had lower survival rates than patients without BBB (RBBB, HR 2.19, 95% CI 1.73 to 2.78, p <0.001; LBBB, HR 3.32, 95% CI 2.67 to 4.13, p ≤0.001), but after adjustment for multiple risk factors an increased risk of mortality for LBBB remained significant. In conclusion, appearance of LBBB or RBBB in patients presenting with angina predicts adverse long-term cardiovascular outcomes compared to patients without BBB.
Identification of Individual Proteins in Complex Protein Mixtures by High-Resolution, High-Mass-Accuracy MALDI TOF-Mass Spectrometry Analysis of In-Solution Thermal Denaturation/Enzymatic Digestion

Identification of individual proteins in complex protein mixtures by high-resolution (HR), high-mass-accuracy matrix-assisted laser desorption/ionization (MALDI) time-of-flight mass spectrometry (TOF-MS) is demonstrated for synthetic protein mixtures. Instead of chemical denaturation, thermal denaturation followed by in-solution trypsin digestion is used to achieve uniform digestion of the constituents of the protein mixture. Protein identification is carried out using protein database searches with search scoring systems, which seems more effective than conventional peptide mass mapping without using a scoring system. Identification of individual proteins by MALDI HR-TOF-MS peptide mass mapping dramatically reduces data acquisition/analysis time and does not require special equipment for sample preparation/transfer prior to mass spectral analysis.
Horticultural mineral oil applications for apple powdery mildew and codling moth, Cydia pomonella (L.)

Abstract Horticultural mineral oil (Orchex 796) was tested in two treatment regimes, either a three-spray early season program targeting apple powdery mildew, Podosphaera leucotricha (All. & Evherh.) Salm. (Oil/Disease treatment) or a six-spray program targeting both generations of codling moth, Cydia pomonella (L.) (Oil/CM treatment), on apple, Malus domestica Borkhausen. These treatments were compared with a check, which received no post-bloom applications of oil. Apple powdery mildew shoot infestation was suppressed only in 1 year of the study (1999) by the Oil/Disease treatment, but no differences in fruit damage were found. The six-spray program of horticultural mineral oil produced the highest percentage of clean fruit, and the lowest level of codling moth-damaged fruit, but only one out of the 3 years of the study. Even in the best treatment in this year, codling moth damage was unacceptably high. Campylomma verbasci (Meyer-Dur) fruit damage was reduced by the oil sprays timed for mildew, probably because of the petal fall spray included in this treatment. Rosy apple aphid, Dysaphis plantaginea (Passerini), densities were suppressed (1 year only) by both oil treatments, while apple aphid, Aphis pomi De Geer, populations were not influenced by oil treatments at any time during the study. White apple leafhopper nymphs, Typhlocyba pomaria McAtee, and tetranychid mite populations were consistently suppressed by both oil treatment regimes, with generally higher levels of suppression occurring with the higher number of applications, despite the lack of specific timing. The same was true of apple rust mite, Aculus schlechtendali (Nalepa), and the western predatory mite, Galandromus occidentalis (Nesbitt).
Review: Biocatalytic transformations of ferulic acid: an abundant aromatic natural product

In this review we examine the fascinating array of microbial and enzymatic transformations of ferulic acid. Ferulic acid is an extremely abundant, preformed phenolic aromatic chemical found widely in nature. Ferulic acid is viewed as a commodity scale, renewable chemical feedstock for biocatalytic conversion to other useful aromatic chemicals. Most attention is focused on bioconversions of ferulic acid itself. Topics covered include cinnamoyl side-chain cleavage; nonoxidative decarboxylation; mechanistic details of styrene formation; purification and characterization of ferulic acid decarboxylase; conversion of ferulic acid to vanillin; O-demethylation; and reduction reactions. Biotransformations of vinylguaiacol are discussed, and selected biotransformations of vanillic acid including oxidative and nonoxidative decarboxylation are surveyed. Finally, enzymatic oxidative dimerization and polymerization reactions are reviewed.
Reading and the corpus callosum: An MRI family study of volume and area.

This study examines the corpus callosum in 68 readers nested in 24 families. Callosa were measured and controlled for whole brain volume, intelligence, and gender. The relation of corpus callosum size to the within-family variance of oral reading was investigated with various measurements: volume, midsagittal area, and anterior-to-posterior one-fifth area segmentations. Because this is the first known publication of MRI calculations of corpus callosum volume, some basic questions about bilateral symmetry and the efficacy of area versus volumetric measurements were explored. Results suggest that better readers within families have larger midsagittal areas at the midbody. Although reliably measured, volume did not contribute to oral reading but was highly correlated with area. Bilateral volumes of the corpus callosum were symmetric.
Singlet molecular oxygen by direct excitation

Direct excitation at 1064 nm and detection of singlet molecular oxygen at 1270 nm is made possible by the availability of powerful YAG-lasers and sensitive NIR photomultipliers. Singlet oxygen was generated in condensed phase at 77 K by direct excitation at 1064 nm (without the use of sensitizers). Several luminescing species were observed by time resolved luminescence spectroscopy and luminescence lifetime measurements, including the single molecule 1Δgand 1Σg+states as well as luminescence from the [1Δg]2 simultaneous transition. As an application we propose a novel method for obtaining quantitative non-intrusive mapping of the 2-D oxygen concentrations and pressure at cryogenic temperatures, which is of importance in aircraft design for high altitudes.
Antigen-dependent B-cell development.

There is growing evidence that the development of naive B cells depends on the interaction of self antigens with the BCR. A view that has emerged over the past year is that BCR signal output contributes in a large part to the developmental fate of peripheral B cells. Differences in antigen-receptor signal strength may determine whether B cells assume a marginal zone, follicular or B-1 phenotype.
Prognostic significance of DNA aneuploidy in diffuse malignant mesothelioma.

DNA ploidy of pepsin digested preparations of 48 paraffin-embedded specimens from 19 patients with histologically confirmed malignant mesothelioma was determined by laser flow cytometry. Eight of the 19 tumors (42%) were diploid and 11 (58%) were aneuploid. Of the aneuploid tumors, only one showed multiploidy. The median survival time of the patients with diploid tumors was 19, 16, and 14 months from the onset of symptoms, diagnosis, and treatment, respectively. The median survival in patients with aneuploid tumors was 8, 7, and 7 months from the onset of first symptoms, diagnosis, and treatment. Thus, patients with diploid tumors lived longer than patients with aneuploid tumors. These results suggest that DNA ploidy analysis may be of prognostic value in malignant mesothelioma. 31 refs., 2 figs., 3 tabs.
IEEE 1451.0 compatible TEDS creation using .NET framework

IEEE 1451, a suite of Smart Transducer Interface Standards, has been developed by the Instrumentation and Measurement Society's Sensor Technology Technical Committee TC-9 at the Institute of Electrical and Electronics Engineers [3]. IEEE 1451 family of standards has three approved and three proposed standards that share certain characteristics, but have no common set of function protocols, and TEDS formats that provide interoperability among these standards. IEEE 1451.0 provides that common functionality and simplifies the creation of future standards for different physical interfaces while maintaining interoperability among the IEEE 1451 family members [2]. This paper describes the creation of Transducer Electronic Data Sheets (TEDS) developed based on the IEEE 1451.0 standard using .NET Framework.
The Employment of the Phenomenological Psychological Method in the Service of Art Education

Abstract The concern of this study is the consequences of art education information on the experiencing of a painting that has already been experienced in a condition naive to such information. It is believed that experiential data of viewers with respect to such consequences can be accessed by way of the phenomenological approach. The phenomenological psychology and methodology that are representative of this approach are that of Amedeo P. Giorgi. The employment of Giorgi’s phenomenological psychological method in this study is in the service of education and pedagogy. Giorgi’s history of research on a phenomenological psychology and the method specific to it goes back a number of decades. Four major presentations by Giorgi (1985, 2009; Giorgi & Giorgi, 2003, 2008) are the sources for designing the study here in the use of his method. Giorgi’s (2009) book is the major source for the understanding of his development and use of the method.