cssi/SciSciGPT-SciSciNet huggingface dataset:
Purification and characterization of CAF-I, a human cell factor required for chromatin assembly during DNA replication in vitro

The purification and characterization of a replication-dependent chromatin assembly factor (CAF-I) from the nuclei of human cells is described. CAF-I is a multisubunit protein that, when added to a crude cytosol replication extract, promotes chromatin assembly on replicating SV40 DNA. Chromatin assembly by CAF-I requires and is coupled with DNA replication. The minichromosomes assembled de novo by CAF-I consist of correctly spaced nucleosomes containing the four core histones H2A, H2B, H3, and H4, which are supplied in a soluble form by the cytosol replication extract. Thus, by several criteria, the CAF-I-dependent chromatin assembly reaction described herein reflects the process of chromatin formation during DNA replication in vivo.
A gene expression signature predicts survival of patients with stage I non-small cell lung cancer

Background Lung cancer is the leading cause of cancer-related death in the United States. Nearly 50% of patients with stages I and II non-small cell lung cancer (NSCLC) will die from recurrent disease despite surgical resection. No reliable clinical or molecular predictors are currently available for identifying those at high risk for developing recurrent disease. As a consequence, it is not possible to select those high-risk patients for more aggressive therapies and assign less aggressive treatments to patients at low risk for recurrence.
Designing Privacy Into Online Communities

Participation has exploded in online communities such as social networking sites, media sharing sites, and blogging sites. This widespread participation has generated substantial concern about the privacy implications of use. Although most online communities include privacy management features, it is not well understood how members of online communities take advantage of privacy management. To explore this issue, a study was conducted that compared privacy management on Facebook and MySpace, two popular social networking sites. Out of 222 subjects, 18.9% or nearly one in five had suffered a privacy incident within the past year. In a particularly striking result, less than half of those who suffered a privacy incident either reviewed or changed their privacy settings. So even though privacy incidents occur regularly, these findings indicate privacy management tools are not extensively used to protect privacy. This provides evidence of poor design of privacy management on social networking sites. To improve design, we argue that privacy must be conceptualized as a quality of an online space, rather than as a collection of access settings to be managed by individual members. This moves privacy from an individual consideration to the level of a structural component of a system. We offer an analysis of current privacy management practices and offer suggestions for improving the design of privacy management in social software.
Fraenkel's Partition and Brown's Decomposition

We give short proofs of Fraenkel’s Partition Theorem and Brown’s Decomposition. Denote the sequence (b (n − � 0 )/�c ) 1=1 by B(�,� 0 ), a so-called Beatty sequence. Fraenkel’s Partition Theorem gives necessary and sufficient conditions for B(�,� 0 ) and B(�,� 0 ) to tile the positive integers, i.e., for B(�,� 0 ) \ B(�,� 0 ) = ; and B(�,� 0 ) [ B (�,� 0 ) = N. Fix � 2 (0,1), and let ck = 1 if � ,
P.E.T. RADIOPHARMACEUTICALS VIA REDUCTIVE CARBOXYLATION

Positron Emission Tomography (PET) is a powerful imaging diagnostic tool which uniquely provides qualitative and quantitative measurement of metabolic processes in vivo in normal and pathological tissue via application of appropriate radiotracers. Recently, there has been great interest in the development of fast and efficient new synthetic methodologies for positron emitting radiolabeled pharmaceuticals which can be used as tracers for P.E.T. studies. In the last decade, a variety of N-[11C] labeled radiopharmaceuticals1–2 have been synthesized via methylation of the appropriate desmethyl precursors with [11C]CH3I or reductive methylation with [11C]HCHO/NaBH3CN. In principle, both of these reagents [11C]CH3I or [11C]HCHO have been prepared from the more readily available [11C]CO2 via reduction to [11C]CH3OH, followed by iodination or oxidation as illustrated in Scheme-1. Further examination of the N-[11C] radiopharmaceuticals reveals that these bioactive molecules can be easily prepared directly from [11C] carbon dioxide under appropriate conditions. We have, therefore, investigated the use of [11C]CO2 as a radiolabeled precursor in the preparation of a variety of [11C] labeled compounds. In order to develop new synthetic methodologies for direct incorporation of [11C]CO2 into bioactive molecules, synthesis should be short and efficient and should be complete within three half-lives of the radioisotope. In general, literature synthetic procedures3 using [12C] or [14C]CO2 are not applicable for the synthesis of [11C] labeled radiopharmaceuticals because of the short 20.4 min half-life of the [11C] isotope. Hence, either extremely modified or entirely new procedures are desirable. A general reaction of [11C]CO2 with organometallics has been widely used for the preparation of [11C] carboxylic acid derivatives.
Performance of Portfolios Optimized with Estimation Error

We explain the poor out-of-sample performance of mean-variance optimized portfolios, developing theoretical bias adjustments for estimation risk by asymptotically expanding future returns of portfolios formed with estimated weights. We provide closed-form non-Bayesian adjustments of classical estimates of portfolio mean and standard deviation. The adjustments significantly reduce bias in international equity portfolios, increase economic gains, and are robust to sample size and to nonnormality. Dominant terms grow linearly with the number of assets and decline inversely with the number of past time periods. Under suitable conditions, Sharpe-ratio maximizing tangency portfolios become more diversified. Using these approximation methods it may be possible to assess, before investing, the effect of statistical estimation error on portfolio performance.
Costorage and Corelease of Modulatory Peptide Cotransmitters with Partially Antagonistic Actions on the Accessory Radula Closer Muscle ofAplysia californica

Many neurons that contain a classical neurotransmitter also contain modulatory peptides, but it has been difficult to establish unequivocally that these peptides are functional cotransmitters. Here, we provide evidence for functional cotransmission in a neuromuscular system of Aplysia. Using immunocytochemical techniques, we localize members of two peptide families, the small cardioactive peptides (SCPs) and the buccalins (BUCs), to a single subset of dense-core vesicles in the terminals of the cholinergic motorneuron B15. We describe a new preparation and method for the direct detection of released peptides and show that the SCPs and BUCs are released when neuron B15 is intracellularly stimulated. Consistent with their subcellular localization, the SCPs and BUCs are released in a stoichiometric ratio that is constant across conditions that change the absolute amount of peptides released. Peptide release is calcium-dependent but does not require muscle contractions. Thus, the release cannot be attributed to a displacement of peptides that may be present in the extracellular space. In previous studies, we characterized the physiological firing patterns of neuron B15. Here, we simulate these firing patterns and show that peptide release occurs. Additionally, we find that significant quantities of material are released under behaviorally relevant conditions. We find that concentrations of released peptides in the muscle are in the concentration range in which exogenously applied peptides exert characterized modulatory actions on muscle contractions. Together, our findings provide strong support for the hypothesis that peptides contained in neuron B15 are functional cotransmitters.
University Residence Hall Assistants as Mediators: An Investigation of the Effects of Disputant and Mediator Relationships on Intervention Preferences1

The present research investigated whether (a) preexisting affiliation (bias) between a mediator and 1 disputant and (b) interpersonal hostility between 2 disputants affected university Residence hall Assistants' (RAs') mediation strategies. Respondents (N = 45) read 1 of 4 versions of a dispute scenario; versions varied independent variables according to a 2 × 2 design (high vs. low mediator affiliation and high vs. low disputant hostility). Respondents indicated the probability of using 18 mediation techniques. Results suggested that both independent variables significantly affected strategy selection. When friends with the complainant, the RA was likely to first avoid mediating. Hostility between disputants was related to less problem solving. In all conditions. RAs mentioned techniques consistent with stage theories of mediation, moving from problem definition to problem solving to pressing the parties.
Testing Community Velocity Models for Southern California Using the Ambient Seismic Field

Abstract We correlate the vertical component of ambient seismic noise data recorded on 56 broadband stations with dense coverage in the greater Los Angeles area to determine station-to-station Green’s functions. These Green’s functions provide an important test of community velocity models (Southern California Earthquake Center [SCEC] CVM 4.0 and CVM-H 5.2) used for strong ground-motion prediction for future scenario earthquakes in southern California. Comparisons of the ambient-noise Green’s functions for nearly 300 paths, with those calculated by the finite-element method in the community velocity models, reveal a strong waveform similarity for the dominant surface waves between 0.1 and 0.2 Hz. We find a mean correlation coefficient between the ambient-noise and finite-element Green’s functions of 0.62 for the CVM 4.0 and 0.49 for the CVM-H 5.2, indicating stronger waveform similarity for CVM 4.0. We also find that for 77% of the paths, the surface waves in the finite-element Green’s functions for CVM 4.0 arrive early, suggesting that the CVM 4.0 has velocities in the upper 10 km that are too fast along these paths. The same bias is evident for CVM-H 5.2, but is substantially smaller, with only 61% of the paths too fast. For 67% of the paths, CVM 4.0 has velocities faster than CVM-H 5.2. The time lags we obtain between the ambient-noise and finite-element Green’s functions provide key information for improving future community velocity models.
Ultra-high thermal conductivity of three-dimensional flat-plate oscillating heat pipes for electromagnetic launcher cooling

Bore components within electromagnetic launchers (EMLs) experience very high heating rates during and after the shot of a projectile. This is a challenge for the next-generation EML which will shoot projectiles repetitively within a specified time frame. Direct integration of three-dimensional flat-plate oscillating heat pipes (3D FP-OHPs) for thermal management of EML bore components is proposed. Unlike conventional heat pipes, the 3D FP-OHP contains no wick structure and can operate at higher heat fluxes with fewer limitations. Proof-of-concept experiments were performed on a copper 3D FP-OHP (130.18 mm × 38.10 mm × 2.86 mm) filled with HPLC-grade water at a filling ratio of 72%. The 3D FP-OHP was found to have an effective thermal conductivity that increased with heat input - approaching 15,000 W/m-K at heat inputs on-the-order of 0.3 kW. This experimentally-determined thermal conductivity was used for numerically analyzing the thermal performance of a longer 3D FP-OHP configured for axial EML thermal management. These results indicate that the high thermal conductivity of 3D FP-OHP coupled with an external, active cooling solution (h ∼ 50,000 W/m2-K) can provide for peak heat transfer rates on-the-order of 10 kW. Based on these results, the 3D FP-OHP is appealing for future EML thermal management solutions, however significant work is required for their optimal integration.
Parenting Predictors of Delay Inhibition in Socioeconomically Disadvantaged Preschoolers.

This study examined longitudinal associations between specific parenting factors and delay inhibition in socioeconomically disadvantaged preschoolers. At Time 1, parents and 2- to 4-year-old children (mean age = 3.21 years; N = 247) participated in a videotaped parent–child free play session, and children completed delay inhibition tasks (gift delay-wrap, gift delay-bow, and snack delay tasks). Three months later, at Time 2, children completed the same set of tasks. Parental responsiveness was coded from the parent–child free play sessions, and parental directive language was coded from transcripts of a subset of 127 of these sessions. Structural equation modelling was used, and covariates included age, gender, language skills, parental education, and Time 1 delay inhibition. Results indicated that in separate models, Time 1 parental directive language was significantly negatively associated with Time 2 delay inhibition, and Time 1 parental responsiveness was significantly positively associated with Time 2 delay inhibition. When these parenting factors were entered simultaneously, Time 1 parental directive language significantly predicted Time 2 delay inhibition whereas Time 1 parental responsiveness was no longer significant. Findings suggest that parental language that modulates the amount of autonomy allotted the child may be an important predictor of early delay inhibition skills. Copyright © 2015 John Wiley & Sons, Ltd.
Management of orthopteran pests: a conservation perspective

Although the vast majority of orthopterans are not pests, some species have the potential to cause serious damage to human interests. Management of pest populations frequently conflicts with conservation of orthopteran species and processes, particularly when the pest species or its ecological processes are susceptible to extinction or when the pest population is coincident with non-target orthopterans. With respect to chemical control, the greatest hazards are the broad-spectrum, highly lethal properties of most agents, which can be mitigated with formulation and application methods. Biological control risks permanent, large-scale changes to orthopteran species and processes which can be minimized with bioinsecticidal and other short-lived or selective formulations and reliable host-range testing. Cultural control may have large-scale, broad-spectrum impacts to non-target orthopterans, but these hazards can be diminished by appropriate testing and monitoring. Mechanical control methods may be impractically labour intensive, but they are highly target specific and therefore warrant further consideration. Social control measures such as education, insurance and compensation programmes appear to have little direct potential for harm to orthopteran conservation, but the complex socioeconomic and, ultimately, environmental consequences of such programmes have not been assessed. The melding of orthopteran pest management and conservation requires that we perceive these insects and their ecological processes to be vital elements of sustainable agroecosystems. Our management of orthopterans (both non-target and pest populations) must focus on keeping good stewards on the land.
Decisions and Power

In the West, everyone ridicules and disparages committees. In many ways, committees have come to symbolize what Americans and Westerns dislike most about meetings: inefficiency, cumbersome procedures, unfruitful discussions, and so forth. In his excellent book, Government by Committee (1955), K. C. Wheare examines the role of committees in the machinery of the British government. He suggests that their prevalence in the government must be examined as he cites Winston Churchill’s complaint during a moment of exasperation during World War II as he exclaimed: “We are overrun by them [committees], like the Australians were by the rabbits” (p. 1). In examining the phenomenon of “government by committee,” Wheare demonstrates the general approach that researchers have taken toward meetings and meeting groups, such as committees and boards. First, he classifies these groups based on the tasks that they are asked to perform, and so he compares and contrasts committees to advise (e.g., panels, councils, working parties), committees to inquire (e.g., royal commissions, select committees of the House of Commons, departmental and interdepartmental committees), committees to negotiate (e.g, committees engaged in settling questions of hours of labor, wage rates, and conditions of work in central or local government service), committees to legislate (e.g., standing committees of the House of Commons), committees to administer (e.g., committees used by local authorities of the country), committees to scrutinize and control (e.g., select committees of the House of Commons—of Public Accounts, on Estimates, and on Statutory Instruments) (p. 2). In the case of each of these six different types of committees, Wheare examines the effectiveness of the committee based on whether or not they accomplish their designated task, which in general means whether or not they “decide something”: If we are to judge whether a committee is doing its work well, we must have in our minds certain criteria of success, which we must attempt to formulate in advance, however, vaguely. In the first place it can be said that it is the job of a committee to come to a conclusion, to decide something. Its decision may be a finding of fact or a recommendation to its parent body or an administrative order or an appointment or a proposal to defer consideration. Whatever its function, however, it is its job to take a decision upon the matter before it. If it fails to do that, then it is not doing its work. It may seem absurd to assert so self-evident a proposition, but it has to be asserted because committees have been known to fail to perform this task. (p. 10)
Facile Conversion of an Appended Silylamido to a Silyloxy Ligand via Isocyanate Elimination. Synthesis of {[(C5Me4)SiMe2O]Zr(η2-O2CMe)(μ-O2CMe)}2 via the Carboxylation of [(C5Me4)SiMe2(N-t-Bu)]ZrMe2

The reaction of 2 equiv of CO2 with [(C5Me4)SiMe2(N-t-Bu)]ZrMe2 proceeds with the formation of {[(C5Me4)SiMe2(N-t-Bu)]Zr(η2-O2CMe)(μ-O2CMe)}2 (2), which reacts with additional CO2 to afford {[(C5Me4)SiMe2O]Zr(η2-O2CMe)(μ-O2CMe)}2 (3) with the concomitant elimination of OCN-t-Bu. The formation of OCN-t-Bu was confirmed by a combination of GC/MS and IR measurements; the molecular structures of 2 and 3 were determined by X-ray crystallography.
Age differences in personal health practices of rural women.

Do older rural women have more positive health practices than younger rural women? Belloc and Breslow ( 2 ) examined seven practiceseating breakfast, snacking, regular exercise, sleep, smoking, alcohol use, and maintaining desirable body weight-in an urban population and found that more of the older than the younger respondents practiced all seven of these behaviors. Other researchers (1, 3, 4 ) also reported higher frequencies of positive health behaviors in older urban populations. The purpose of the present study was to examine the prevalence of health practices among rural women and to analyze differences among age groups. A survey was conducted by mail of 10 rural counties in Kansas. Potential subjects (n = 1500) were selected from telephone directories. The survey included selected demographic information and seven personal health practices. The final response rate was 44.5%. The distribution of respondents by age, race, and marital status was comparable to that of the 1980 Census population. The proportion of respondents with higher education (36 9 % ) is greater than that of the female population in Kansas (23.6%). There was a s~gnificant ( X q p 5 .01) difference between younger and older women for six of the health practices. The proportions of rural women who are nondrinkers, nonsmokers, nonsnackers, and breakfast eaters are higher in the older age groups. More younger women exercise and maintain desirable body weight than do older women Sleep did nor show a significant age-related pattern. Older rural women do have a greater number of positive health practices than do younger rural women, but older rural women in Kansas did not report as many positive health practices as their urban counterparts. The greater proportion of older rural women not exercising and maintaining desirable body weight may be the result of several factors not examined in this study, such as metabolism, lack of support or facilities for exercise, and diet. The greater proportion of nonsmokers among rural women compared to urban women may also explain the lower proportion of older rural women with desirable body weight. Finally, it must be noted that the low response rate may have introduced a bias inro the results. With these limitations, the findings must be carefully weighed.
A Test Selection Procedure for Improving the Accuracy of Defect Diagnosis

Procedures that were described earlier increase the accuracy of defect diagnosis by ignoring small subsets of tests in order to produce smaller candidate fault sets. The premise behind these procedures is that most of the tests in a given test set are useful for defect diagnosis, and only small numbers of tests need to be ignored. This paper makes the new observation that it is possible to use small subsets of tests to obtain more accurate diagnosis results. This paper describes a procedure that starts from an empty test set, and adds tests one at a time. The test selected at every iteration is the one that results in the smallest candidate fault set. The addition of tests increases the number of candidate faults gradually. Experimental results for benchmark circuits demonstrate that the addition of tests provides more candidate fault sets with higher degrees of accuracy than the removal of tests. One of these candidate fault sets can be used for failure analysis.
Are small, isolated prairie remnants effectively smaller than they look and getting smaller?1,2

Abstract To evaluate the floristic sustainability of three small, isolated tallgrass prairie remnants, spatial and temporal patterns of species and functional group (FG) composition, richness, diversity, and dominance were examined to determine whether there was divergence between edge (outer 10 m) and interior zones. These remnants, all protected and managed nature preserves, are rectangular in shape and range in area from 1.29 ha to 1.77 ha; each is bordered by cropland and unmanaged or mowed ruderal grassland. A stratified sampling design was established using permanently marked transects oriented perpendicular to the long axis of each site. Vegetation data were collected in 50 cm × 50 cm quadrats along each transect; prairies were resampled 5–6 yr following baseline data collection. The null expectations were no differences between edge and interior zones, no differences between edge type (crop and noncrop), and no change over time. Results from linear mixed-effects models identified significant diffe...
[Genome sequences of coxsackievirus B5 isolated from viral encephalitis patients in Henan province, 2011].

Objective To analyze the complete genome sequences of two coxsackievirus B5 (CVB5) isolated in Henan province,2011.Methods Specimens were collected from viral encephalitis patients and followed by viral isolation on them.RNA were extracted from positive isolates and the amplified products were sequenced.The full-length genomes of them were acquired by assembling the fragments,using DNAStar 5.01 software while phylogenetic analysis were performed with Mega 5.05 and other software.Results The genomes RNA of 03001N and 17Y showed 7408 bp and 7404 bp long,and the 5'-and 3'-untranslated regions were 747 bp,743 bp and 103 bp,103 bp,respectively.BLAST analysis of these two isolates,based on the complete genome,showed 97％ identity,with both of them having the highest similarity (98％,99％) to the CVB5 strain isolated from Henan in 2010 rather than other CVB5 strains.Coding regions of both isolates were 6558 bp,code for a polyprotein of 2185 amino acids (aa) and both of them showed 99％ amino acid identity.Phylogenetic tree in VP1 region showed that the two isolates belonged to the same clade with other strains isolated from all over the country in the past years,except for some CVB5 strains isolated from Henan and Shandong province in 2009 that formed the other cluster.Conclusion It seemed that more than one group of CVB5 were circulating in Henan province and these two isolates appeared the main epidemic strains circulating in the past years. Key words: Coxsackievirus B5 ; Encephalitis; Phylogenetic analysis
Thinking Outside the (Lunch) Box

I am a family physician in the Bronx, New York. My patients are predominantly lower-income minorities who face many obstacles to healthy eating. During patient visits, I have seen Coca-Cola in baby bottles and french fries as infant food. A common theme in my patients’ diets is a paucity of whole foods and a preponderance of ultraprocessed products. Certainly, education plays a role; my patients generally have lower levels of schooling and lower health literacy. Part of my job as a physician is to educate. Given that nutrition impacts general health and wellness and the management of virtually all disease states, I find myself counseling on diet at most patient visits. When I see a young boy for a checkup and his mother has provided him with chips, candy, and a sugary drink as an examination room snack, I am affected by the image. I too have a son, but my son eats differently. His whole environment is different. At least, so I thought.
Reimagining History to Alter the Future: Demea’s Interrogation of Two Colonial Ideologies

In the nineteen-fifties, South African scholar and poet Guy Butler wrote Demea , an adaptation of Euripides’ masterwork, Medea . The play carried with it a strong message against apartheid and a possible solution for South Africa’s future. Due to government censorship, the play went unpublished and unperformed for nearly four decades. With the abolition of apartheid in 1990, national mythologies were struck down, and people were left to reframe their memories according to the new South African socio-political paradigm. The long overdue production and subsequent publication of Demea provided South Africa with a reimagined history and proposed a way of moving forward as a nation. By placing the events of Demea during the Great Trek of the nineteenth century, Butler is able to criticize the present and conceive a possible future by looking through the lens of the past. Butler sets up two treks. The first is historically accurate, and led by the Creon character, Kroon. This trek exemplifies European colonialism. The second trek, of Butler’s own construction, is composed not of Boers, but of people of diverse racial backgrounds. This imaginary trek, led by Jonas (the Jason character), mirrors the Greek archaic colonial ideology. Thus, Demea offers an interrogation of two national mythologies regarding colonialism, ultimately proposing a solution to apartheid in the form of an altered history.
Get Kahoot!: The Pedagogical Utility of a Game-Based Learning Platform

BRIEF SESSION DESCRIPTION:This session will explore how Kahoot can support a variety of pedagogical methods to increase student learning, comprehension, and class interaction.________________________________________________________________FULL ABSTRACT: I will be demonstrating how to use a game-based learning platform, Kahoot, in ways that support a variety of pedagogical methods to increase student learning and comprehension as well as class interaction and subject interest. The learning platform can be used to collect information through the use of surveys, test students' prior knowledge through content-based quizzes, both as individuals and in small groups, present new information through one-right answer quizzes, and serve as a foundation for developing classroom discussions and learning. Participants will be able to experience these tools in real time during the demonstration (just as students would), and I will provide examples of surveys and quizzes that were successful in my classes this year.AÂ Participants will learn ways to use Kahoot to accomplish multiple pedagogical goals while raising levels of student interest in the subject matter (works for a wide variety of disciplines).
Multiple bunch HOM evaluation for ERL cavities

Abstract In this work we investigate the effect of the bunch pattern in a linac on the Higher Order Mode (HOM) power generation. The future ERL-based electron–ion collider eRHIC at BNL is used as an illustrative example. This ERL has multiple high current Superconducting Radiofrequency (SRF) 5-cell cavities. The HOM power generated when a single bunch traverses the cavity is estimated by the corresponding loss factor. Multiple re-circulations through the Energy Recovery Linac (ERL) create a specific bunch pattern. In this case the loss factor can be different than the single bunch loss factor. HOM power can vary dramatically when the ERL bunch pattern changes. The HOM power generation can be surveyed in the time and frequency domains. We estimate the average HOM power in a 5-cell cavity with different ERL bunch patterns.
Semi-quantitative assessment of resting perfusion in chronic myocardial infarction

Background Based on observations from cardiovascular magnetic resonance (CMR) imaging, it is not clear whether chronic myocardial infarction (MI) is associated with abnormal perfusion at rest. Our aim was to investigate this question using semi-quantitative analysis of resting myocardial perfusion to compare areas of infarct and remote myocardium in patients with known coronary anatomy. Methods We identified 19 patients who underwent regadenoson stress CMR (1.5T, Philips), had MI confirmed by late gadolinium enhancement (LGE), and underwent invasive coronary angiography within 6 months of CMR. Stress perfusion images were obtained during first pass of Gadolinium contrast agent one minute after regadenoson (0.4mg IV bolus) injection, and followed by reversal with aminophylline (75-125 mg), rest perfusion and late gadolinium enhancement (LGE) imaging 10-15 minutes later. Resting time-intensity curves were generated for a region of interest (ROI) in the area of MI, remote myocardium, and blood pool (Medis). Myocardial curves were used to obtain maximal up-slopes and normalized by the blood pool. Up-slopes were compared between the infarcted and remote myocardial ROIs. Results There was no significant difference between the slopes in the infarcted and remote myocardium (0.31 ± 0.17 vs 0.32 ± 0.18 1/s) irrespective of presence of significant stenosis
Hidden Fees and Firm Reputation: Evidence from the U.S. Hotel Industry

Does engaging in price obfuscation damage firm reputation? Using a difference- in-differences framework applied to data from the U.S. hotel industry, I establish that a firm’s adoption of hidden “r...
MTBP, the Partner of Treslin, Contains a Novel DNA-Binding Domain, That Is Essential for Proper Initiation of DNA Replication

Treslin, which is essential for incorporation of Cdc45 into the replicative helicase, possesses a partner called MTBP. We have analyzed Xenopus and human MTBP to assess its role in DNA replication. Depletion of MTBP from Xenopus egg extracts, which also removes Treslin, abolishes DNA replication. These extracts be can rescued with recombinant Treslin-MTBP, but not Treslin or MTBP alone. Thus, Treslin-MTBP is collectively necessary for replication. We have identified a C-terminal region of MTBP (the CTM domain) that binds efficiently to both double-stranded DNA and G-quadruplex (G4) DNA. This domain also exhibits homology with budding yeast Sld7. Mutants of MTBP without a functional CTM domain are defective for DNA replication in Xenopus egg extracts. These mutants display an impaired localization to chromatin and the inability to support loading of Cdc45. Human cells harboring such a mutant also display severe S-phase defects. Thus, the CTM domain of MTBP plays a critical role in localizing Treslin-MTBP to the replication apparatus for initiation.
Tarsometatarsal joint communication during fluoroscopy-guided therapeutic joint injections and relationship with patient age and degree of osteoarthritis

Although the tarsometatarsal joints are separated into three distinct synovial compartments, communications between adjacent compartments are often noted during image-guided injections. This study aims to determine whether abnormal inter-compartment tarsometatarsal joint communication is associated with patient age or degree of tarsometatarsal osteoarthritis. One hundred forty tarsometatarsal injections were retrospectively reviewed by two radiologists. Extent of inter-compartment communication and degree of osteoarthritis were independently scored. Univariate and multivariable analyses were performed to assess whether the presence of and number of abnormal joint communications were related to age and degree of osteoarthritis. Forty out of 140 tarsometatarsal joints showed abnormal communication with a separate synovial compartment, and 3 of the 40 showed abnormal communication with two separate compartments. On univariate analysis, higher grade osteoarthritis (p < 0.001) and older age (p = 0.014) were associated with an increased likelihood of abnormal inter-compartment tarsometatarsal communication and a greater number of these abnormal communications. On multivariate analysis, the degree of osteoarthritis remained a significant predictor of the presence of (p < 0.001) and number of (p < 0.001) abnormal communications, while the association of age was not statistically significant. There was significant correlation between age and degree of osteoarthritis (p < 0.001). Higher grade osteoarthritis increases the likelihood of abnormal inter-compartment tarsometatarsal joint communication and is associated with a greater number of abnormal communications. Diagnostic injection to localize a symptomatic tarsometatarsal joint may be less reliable in the setting of advanced osteoarthritis.
Temperature and duration targets during post-arrest care: choosing the right prescription for the right patient

Targeted temperature management (TTM) was established as a key post-arrest therapy after the publication of two randomized trials in 2002 (1,2). Both trials showed improvement in favorable neurologic outcomes characterized by Cerebral Performance Categories (CPC) score of 1–2 and a lower 6-month mortality with the use of TTM after out-of-hospital cardiac arrest (OHCA) from ventricular fibrillation or ventricular tachycardia (VF/VT).
Rag1-null Dahl SS rats reveal that adaptive immune mechanisms exacerbate high protein-induced hypertension and renal injury.

The present study, performed in Dahl salt-sensitive (SS) and SS-Rag1−/− rats lacking T and B lymphocytes, tested the hypothesis that immune cells amplify salt-sensitive hypertension and kidney dama...
Recommendations for Future Work

Although there have been a lot of studies dedicated to lost circulation control and great successes have been achieved, the problem continues, with the increasing drilling operations in more complicated environments. Knowledge gaps and unsolved problems still exist and the need for further studies remains. A few recommendations for future work are presented in this chapter.
Toward a visual assistive listening device: Real-time synthesis of a virtual talking face from acoustic speech using deep neural networks

Speech perception is a crucial function of the human auditory system, but speech is not only an acoustic signal—visual cues from a talker’s face and articulators (lips, teeth, and tongue) carry considerable linguistic information. These cues offer substantial and important improvements to speech comprehension when the acoustic signal suffers degradations like background noise or impaired hearing. However, useful visual cues are not always available, such as when talking on the phone or listening to a podcast. We are developing a system for generating a realistic speaking face from speech audio input. The system uses novel deep neural networks trained on a large audio-visual speech corpus. It is designed to run in real time so that it can be used as an assistive listening device. Previous systems have shown improvements in speech perception only for the most degraded speech. Our design differs notably from earlier ones in that it does not use a language model—instead, it makes a direct transformation from speech audio to face video. This allows the temporal coherence between the acoustic and visual modalities to be preserved, which has been shown to be crucial to cross-modal perceptual binding.
Investigações Matemáticas com Grafos para o Ensino Médio

O objetivo deste trabalho foi investigar abordagens metodologicas que podem contribuir para uma introducao do conteudo de grafos na educacao basica, 3a serie do Ensino Medio, de forma a integrar os conteudos de matrizes e analise combinatoria. Orientamo-nos pelo desenho da engenharia didatica, organizando a pesquisa em quatro etapas: analises previas ou preliminares; analises a priori; execucao e analise a posteriori. Os referenciais teoricos que fundamentaram a pesquisa foram: a teoria de registros de representacao semiotica de Raymond Duval e as atividades investigativas nos moldes propostos por Joao Pedro da Ponte. Tomamos como base tambem as etapas de resolucao de problemas sugeridas por Polya para o desenvolvimento e resolucao das situacoes problemas. As atividades elaboradas foram desenvolvidas na forma de uma oficina, atraves de um trabalho em grupos, favorecendo a interacao entre os participantes na socializacao dos resultados obtidos e as diversas formas de representacao dos problemas e suas resolucoes.
Understanding Scribe Profile and Tool Type Effects on Visual Corrosion Assessments

Visual analysis is the most common evaluation of accelerated corrosion performance after exposure using a scribed protective coating on a metal substrate. Although the scribed-coating visual inspection is standardized, the specificity of initial conditions relative to the final performance has never been unified between laboratories, scribing tools, nor by published testing standards. To validate the initial state of the coating performance based on the selected tool, salt spray corrosion tests ASTM B117 and GM14872 were performed on 60 epoxy-amine primer coated UNS 10080/10100 steel test panels with nine different scribes (3 test panels each with 3 non-scribed control panels). The width of the initial scribe greatly impacted the visual corrosion assessment of the test results during ASTM B117, while the initial scribe width had little impact during GM14872. These results suggest that correlating the initial scribe with the final corrosion evaluation of the coating defect resulted in a better inter-comparable evaluation of coatings subjected to visual analysis by accelerated corrosion or electrolyte corrosion.
Solvation and Entropic Regimes in Ion-Containing Block Copolymers

The phase behavior of ion-containing block copolymers is studied using a field-theoretic model consisting of fully mobile ions immersed in a heterogeneous dielectric medium. Two distinct thermodynamic regimes are found to emerge, resulting from the competition between ion translational entropy and solvation free energy. In the regime dominated by entropy, the disordered phase is stabilized by the addition of ions. In the regime dominated by solvation free energy, the disordered phase is destabilized, leading to a “chimney”-like channel of stable ordered phases at sufficiently large ion concentrations. The two regimes are demarcated by the parameter λB, which quantifies the variation in solvation energy upon transferring ions between different dielectric domains. Estimates of λB for experimental systems suggest that the majority of block copolymer electrolytes fall within the solvation regime.
Abstract WP43: Body Mass Index and Clinical Outcomes in Large Vessel Occlusion Acute Ischemic Stroke After Endovascular Therapy: The Obesity Paradox

Background: Obesity has been associated with increased morbidity and mortality in the general population. However, several reports have described lower mortality rates in overweight or obese patien...
Optimal energy resource mix for the US and China to meet emissions pledges

Abstract The emissions pledges of the US and China as outlined in their November 2014 agreement and in the Paris Climate Accord are key aspects of global efforts to reduce greenhouse gas emissions. A number of major US states are still pursuing emissions goals aligned with these targets even though the Trump Administration has withdrawn the US from the Paris Accord. China has also reaffirmed its commitment to its targets. This raises the question of what would be the optimal mix of energy resources each nation should deploy in order to meet its respective target. We examine this question using the Combined Energy and Geoengineering Optimization Model (CEAGOM). Our analysis shows that both nations would need to make significant but achievable adjustments to their respective energy mixes in order to meet their targets.
Mild hypothermia is associated with improved outcomes in patients undergoing microvascular head and neck reconstruction.

Abstract Objective Microvascular free tissue transfer has become the standard for reconstruction for large defects. With long operative times and an increased surface area exposed, transient hypothermia is common, but it is unclear how this impacts surgical outcomes. This study evaluated the impact of core body temperature on free tissue flap outcomes in patients undergoing microvascular reconstruction. Study design Retrospective data analysis. Setting Mount Sinai Hospital; NYC, NY; 2007–2016. Subjects and methods Demographic information, mean/minimum/maximum body temperatures, and the presence of flap complications (venous thrombosis, arterial insufficiency, flap death, wound infection/dehiscence, fistula, chyle leak, hematoma/seroma) of 519 free tissue transfer patients were documented. Binomial logistic regression was used to examine associations between the presence of flap complications and mean temperature. Statistical analysis used SPSS, with p-values ≤0.05 deemed statistically significant. Results 393 soft-tissue and 125 osteocutaneous flaps were included. 19.8% (n = 103) patients had the presence of ≥1 flap complication, while 80.2% (n = 416) did not. Average temperature for all patients was 36.12 ± 0.84 °C, with minimum at 34.43 ± 0.97 °C and maximum at 37.24 ± 1.23 °C. After controlling for several factors including: tumor stage, radiation, diabetes, BMI, age, sex, and flap type, there was a significant association between flap complications and mean intraoperative temperature (Exp(B) = 1.559, p = 0.004). Conclusion Higher intraoperative temperatures were associated with worse outcomes. A mild relative hypothermia may improve flap outcomes in this population. This represents the largest study to date evaluating the impact of intraoperative temperature on free tissue transfer outcomes.
Embedding Economies of Scale Concepts in the Model of Optimal Locations of Fresh Produce Aggregation Hubs

Food hubs are of interest in regional and local food system development because they potentially enhance the sustainability of food supply chains. Expanding on earlier literature, this study introduces economies of scale into an aggregation hub location model and disaggregates production into four seasons to account for geographic and seasonal variation of US fresh produce production. A mixed integer linear programming model is formulated with the objective of minimizing total costs of assembly and first-handler operations. Results suggest scale economies have significant effects on the optimal number, locations, and sizes of aggregation hubs. We model regional and local food systems in a manner more consistent with economic theory and provide a richer framework for policy analysis.
Leveraging Prior Knowledge Asymmetries in the Design of Location Privacy-Preserving Mechanisms

The prevalence of mobile devices and Location-Based Services (LBS) necessitates the study of Location Privacy-Preserving Mechanisms (LPPM). However, LPPMs reduce the utility of LBSes due to the noise they add to users’ locations. Here, we consider the remapping technique, which presumes the adversary has a perfect statistical model for the user location. We consider this assumption and show that under practical assumptions on the adversary’s knowledge, the remapping technique leaks privacy not only about the true location data, but also about the statistical model. Finally, we introduce a novel method termed Randomized Remapping to provide a trade-off between leakage of the users’ location and leakage of the users’ model for a given utility.
Deconstructing bias in social preferences reveals groupy and not-groupy behavior

Group divisions are a continual feature of human history, with biases toward people's own groups shown in both experimental and natural settings. Using a within-subject design, this paper deconstructs group biases to find significant and robust individual differences; some individuals consistently respond to group divisions, while others do not. We examined individual behavior in two treatments in which subjects make pairwise decisions that determine own and others' incomes. In a political treatment, which divided subjects into groups based on their political leanings, political party members showed more in-group bias than Independents who professed the same political opinions. However, this greater bias was also present in a minimal group treatment, showing that stronger group identification was not the driver of higher favoritism in the political setting. Analyzing individual choices across the experiment, we categorize participants as "groupy" or "not groupy," such that groupy participants have social preferences that change for in-group and out-group recipients, while not-groupy participants' preferences do not change across group context. Demonstrating further that the group identity of the recipient mattered less to their choices, strongly not-groupy subjects made allocation decisions faster. We conclude that observed in-group biases build on a foundation of heterogeneity in individual groupiness.
Dreamwork: The Fourth Gospel, Eranos, and the Turn to Psychoanalysis

This chapter analyzes Robert Eisler’s The Enigma of the Fourth Gospel, in which he argues that the Gospel of John consists of a core narrative written by Jesus’s “Beloved Disciple” Lazarus, supplemented with the recollections of John of Ephesus, the former High Priest of the Temple in Jerusalem, and the heterodox interpellations of the heretic Marcion. In 1936 Eisler presented this theory at Eranos, an annual meeting of scholars of religion held in Ascona, Switzerland, where he connected with Carl Jung, whose idea of the collective unconscious would play an important role in Eisler’s Man into Wolf. Finally, the chapter looks at a psychoanalytic case study of a vision of Jesus recorded and published by Eisler and a dream he had at his mother’s house.