cssi/SciSciGPT-SciSciNet huggingface dataset:
Does nursing education promote ageism

The literature is replete with diverse studies about gerontological nursing education on the attitudes of nursing students This study examined the effect of a 3-year curriculum on ageism over all 3 years Students were exposed first to well elderly subjects, then hospitalized older subjects, then severely ill older subjects They were tested with the Kogan's Old People Scale and a semantic differential scale to seehow their attitudes towards older people changed according to their experiences The Kogan scale was most sensitive and showed that older students and those with grandparent role models had better attitudes towards older adults Also, there were great increases in positive attitudes towards ageing in year 1 that slowly decreased by the end of year 3
Restraining carbon emissions: measuring energy use and efficiency in the USA

In this paper, we discuss the difficulties in measuring the effectiveness of policies intended to encourage compliance with international carbon restraint agreements. We establish the connection between energy consumption and carbon emissions, and demonstrate a method of disaggregating changes in each into changes in economic activity and structure, energy intensity and fuel mix factors. We utilize this method to analyze the historical trends in energy consumption and carbon emissions in the USA from 1960 to 1993. We analyze the contributions of the various factors to the restraint or encouragement of energy use and carbon emissions. We conclude that, in general, changes in the levels of economic activity have tended, all other factors being equal, to increase emissions, whereas declines in energy intensity and shifts in fuel mix have tended to restrain emissions. Changes in economic structure have had mixed effects. Finally, we discuss the problems with the available data which make the observation of the impact of energy and carbon policies difficult.
Ventilation in morphine-maintained rhesus monkeys. II: Tolerance to the antinociceptive but not the ventilatory effects of morphine.

The antinociceptive and ventilatory effects of morphine and other opioid agonists were determined in three rhesus monkeys during a period of morphine maintenance, as well as before and after the chronic exposure to morphine. Before the onset of the daily dosing regimen, morphine increased tail-withdrawal latencies from 50°C water, with an ED50 of 6.4 ± 2.1 mg/kg. Daily injection of 3.2 mg/kg morphine produced a rightward displacement of the morphine dose-response curve, increasing the ED50 of morphine to 28.4 ± 12.3 mg/kg. Doubling the daily morphine dose to 6.4 mg/kg resulted in a further shift to the right of the dose-response curve of morphine. After cessation of the daily dosing regimen, the morphine dose-response curve for producing antinociceptive effects returned toward baseline. The antinociceptive effects of the kappa opioid agonist, ethylketazocine, were similar during the period of daily exposure to morphine, and after cessation of the daily dosing regimen. Before the onset of the daily dosing regimen, morphine, ethylketazocine, fentanyl, butorphanol and nalbuphine decreased ventilation in the presence of air or air mixed with CO2. The baseline ED50 value of morphine for decreasing minute volume in the presence of 5% CO2 was 2.9 ± 0.8 mg/kg. The ventilatory effects of morphine and other mu opioid agonists tested were not attenuated during the daily morphine-dosing regimen. After 40 weeks of daily injections of 3.2 mg/kg morphine, the ED50 of morphine for decreasing minute volume in 5% CO2 was 2.3 ± 1.0 mg/kg, and when the daily dose was doubled to 6.4 mg/kg morphine, the ED50 of morphine was 1.5 ± 0.5 mg/kg. The ventilatory depressant effects of the daily injection 3.2 mg/kg morphine were also unchanged during morphine maintenance. The differential development of tolerance to the antinociceptive and ventilatory effects of morphine demonstrates a separation of these two mu opioid agonist effects in rhesus monkeys.
Effects of Alternative Developer Decision-Making Models on the Production of Ecological Subdivision Designs: Experimental Results from an Agent-Based Model

Approaches to residential development have clear effects on the surrounding environments, including those on habitat protection, water quality, transportation and congestion costs, and loss of public open space. Ecological subdivision designs (ESDs) are a means to mitigate some of the most negative effects of low-density dispersed land-use patterns, yet there is not widespread adoption of these alternative approaches to subdivision development. In this paper we attempt to improve understanding of how developers make decisions over development designs and what influences those decisions. Using an agent-based model of residential-housing and land markets, the effects of different developer-decision frameworks on development designs and land use are assessed. The importance of uncertainty in the outcome of new designs, such as ESDs, and the effect of that uncertainty on the cost of credit are possible explanations for the prevalence of conventional, low-density development types, and may be impeding adoption...
STORAGE STABILITY OF CSM: INCREASING FAT TO 6% IN CORN-SOY-MILK BLENDS

SUMMARY —CSM is a high-protein food supplement for infants and preschool children; it consists of partially gelatinized corn meal, toasted soy flour and nonfat dry milk and is fortified with vitamins and minerals. The original CSM formulation contained only 2% fat. Storage stability characteristics were determined for CSM blends containing as much as 6% fat. The fat sources tested were corn germ, full-fat soy flour, refined soybean oil, expeller crude corn oil and a combination of high-fat corn meal with full-fat soy flour. Tests for changes in flavor, free fatty acids, peroxide values and available lysine were made on blends stored at 120°F for 56 days, 100°F for 6 months and 77°F for 1 year. Higher fat content was associated with improved palatability. Flavor scores declined at about the same rate under all test conditions. In experimental blends containing crude corn oil, palatability varied with the particular sample tested. One sample of crude corn oil was satisfactory while another caused off-flavors in the blends.
INFORMED CONSENT: PATIENT'S RIGHT OR PATIENT'S DUTY?

The rule that a patient should give a free, fully-informed consent to any therapeutic intervention is traditionally thought to express merely a right of the patient against the physician, and a duty of the physician towards the patient. On this view, the patient may waive that right with impunity, a fact sometimes expressed in the notion of a right not to know. This paper argues that the rule also expresses a duty of the patient towards the physician and a right of the physician against the patient. The argument turns, first, on the truism that a physician has no obligation to commit a battery, or unauthorized touching, and, second, on the thesis that a patient necessarily cannot consent to something that is unknown to him. The conclusion is drawn that a patient is not free to receive treatment voluntarily without knowledgeably authorizing it.
Measurement challenges for on-wafer RF-SOC test

With the wireless industry pushing towards higher levels of integration, with more system-in-a-package (SIP) and multi-chip module (MCM) technology, known-good-die testing of RF-SOC devices has emerged as the next test challenge. These devices have higher packaging costs compared to the traditional single die integrated circuits (ICs), and potential lower yields, since multiple dice are used. As a result, the cost to perform comprehensive on-wafer testing is outweighed by the cost to scrap the devices during the final package test. In addition, some IC manufacturers are selling bare die to be used in the SIP or MCM of another manufacturer. On-wafer test is then required to ensure that good product is shipped. This paper will use a Bluetooth radio modem chip as an example to discuss the measurement challenges and considerations for known-good die testing of a RF-SOC device. With this example, the difficulty of testing RF functionality on-wafer will be compounded by the need to source and measure RF and digital signals simultaneously, creating signal integrity issues. This paper will explore the challenges of laying out the printed circuit board for the device under test (DUT), including setup of the wafer probe card and assembly. Factors taken into account when selecting a probe station, RF wafer probe card, and ATE test system will then be discussed. This paper will conclude with a discussion of on-wafer calibration, including challenges and solutions. Real results from the Bluetooth radio modem chip example will be used to further the discussion.
Interfacial colloidal sedimentation equilibrium. II. Closure-based density functional theory

In Part I [R. E. Beckham and M. A. Bevan, J. Chem. Phys. 127, 164708 (2007)], results were presented for the sedimentation equilibrium of concentrated colloidal dispersions using confocal scanning laser microscopy experiments, Monte Carlo (MC) simulations, and a local density approximation perturbation theory. In this paper, we extended the modeling effort on those systems to include nonlocal density functional theory (DFT), which is capable of predicting the microstructure of the sediment at length scales comparable to the colloidal particle dimension. Specifically, we use a closure-based DFT formulation to predict interfacial colloidal sedimentation equilibrium density profiles. The colloid-colloid and colloid-surface interactions were modeled with DLVO screened electrostatic potentials using parameters taken directly from the experimental work. The DFT profiles were compared to the experimental and MC results from Part I. Good agreement was found for relatively dilute interfacial colloidal fluids, but agreement was less satisfactory as interfacial layering became more pronounced for conditions approaching the onset of interfacial crystallization. We also applied DFT in an inverse sense using the measured colloid density profile to extract the underlying colloid-surface potential; this can be thought of as a microscopic analog to the well-known procedure of using the macroscopic (coarse-grained) density profile to extract the osmotic equation of state. For the dilute interfacial fluid, the inverse DFT calculations reproduced the true colloid-surface potential to within 0.5kT at all elevations.
Refractometric determination of second‐order transition temperatures in polymers. II. Some acrylic, vinyl halide, and styrene polymers

A refractometric method for determination of second-order transition temperatures of polymers has been extended to include a series of polymers for which the transition occurs between 0° and 75°C. Refractive index data within ±30° to 50°C. of the transition temperature are given for some acrylate, methacrylate, vinyl chloride, vinylidene chloride, and styrene polymers and copolymers. These data show discontinuities which locate the second-order transition temperatures for these polymers. Deviation from the linear relation near Tm has been related to a time effect.
Chemokines in Rheumatoid Arthritis

1 Department of Medicine, Section of Arthritis and Connective Tissue Diseases, Northwestern University Medical School, Department of Medicine, 303 E. Chicago Avenue, Ward Building 3-315, Chicago, IL 60611, USA 2 Department of Medicine, The University of Michigan Medical Center, Ann Arbor, MI 48109, USA 3 Department of Pathology, The University of Michigan Medical Center, Ann Arbor, MI 48109, USA 4 Veteran's Administration Lakeside Medical Center, Chicago, IL 60611, USA 5 Third Department of Medicine, University Medical School, Debrecen, Hungary
LABORATORY EVALUATION OF A DYED FOOD MARKING TECHNIQUE FOR CULEX QUINQUEFASCIATUS (DIPTERA: CULICIDAE)

A method of marking adult Culex quinquefasciatus by feeding the larvae commercial hog chow dyed with methylene blue, Giemsa, and crystal violet was evaluated under laboratory conditions. Of 243 mosquitoes fed the dyed food, 230 had visible marks (94.6%). The dyed food increased the egg-adult development time from 11.4 to 12.1 d. After 9 d, 82.5% of adult mosquitoes dyed as larvae could be identified, and remained detectable for up to 15 d, their maximum laboratory life.
Spring Yield and Silage Characteristics of Kura Clover, Winter Wheat, and in Mixtures

Kura clover (Trifolium ambiguum M. Bieb.) grown in monoculture is difficult to harvest mechanically because of its decumbent growth habit, and legumes in general have poor ensiling characteristics. Our objectives were to assess forage yield, nutritive value, and silage characteristics of kura clover–winter wheat (Triticum aestivum L.) mixtures to determine usefulness as a silage crop. ‘Cardinal’ winter wheat was sown in monoculture and into an ‘Endura’ kura clover sward in autumn at two locations and in 2 yr, and harvested at wheat boot and milk stages the following spring. Sole kura clover was harvested at the same time as winter wheat and mixtures. In addition, two mixtures of kura clover with winter wheat were created at each harvest by blending desired proportions from crops grown in monoculture. The mixture of kura clover with winter wheat yielded 7.4 Mg dry matter (DM) ha 21 while sole kura clover yielded 3.4 Mg DM ha 21 and sole winter wheat 9.05 Mg DM ha 21 . However, kura clover yield in the binary mixture was similar to sole kura clover. Neutral detergent fiber and acid detergent fiber concentrations were lower in kura clover than winter wheat and intermediate in mixtures. Fermented mixtures had similar pH to sole winter wheat (pH 3.8) and lower than sole kura clover(pH4.1).TheproportionoftotalNrecoveredasnonproteinNin silage was 9% lower in kura clover and in mixtures than in winter wheat. Water-soluble carbohydrate (WSC) concentrations of wilted foragewerehigher inmixtures thansole kuraclover(157 vs.105gkg 21 DM), and mixtures had lower WSC than sole winter wheat (198 g kg 21 DM). Lactate concentration was 13% higher in silage from mixtures than sole kura clover. Spring forage production of kura clover–winter wheat mixtures was greater than sole kura clover, possessed adequate nutritive value for high-producing livestock, and mixture silage characteristics were better than sole kura clover.
99mTc-HMPAO–Labeled WBC Scan for the Diagnosis of Chronic Recurrent Multifocal Osteomyelitis

The goal of this teaching case study is to demonstrate the novel use of (99m)Tc-HMPAO-labeled white blood cells (WBCs) in diagnosing chronic recurrent multifocal osteomyelitis (CRMO). (99m)Tc-HMPAO-labeled white blood cells were utilized to diagnose CRMO. Classically, CRMO is evaluated scintigraphically using (99m)Tc-methylene diphosphonate/hydroxymethylene diphosphonate. (99m)Tc-HMPAO-labeled WBCs were chosen over (111)In-labeled WBCs because of the former's improved imaging characteristics and decreased radiation dose. (99m)Tc-HMPAO-labeled WBCs were successful in diagnosing CRMO. (99m)Tc-HMPAO-labeled WBC scanning is specific for the diagnosis of CRMO.
Pyrene‐Based Quantitative Detection of the 5‐Formylcytosine Loci Symmetry in the CpG Duplex Content during TET‐Dependent Demethylation

Methylcytosine (5mC) is mostly symmetrically distributed in CpG sites. Ten-eleven-translocation (TET) proteins are the key enzymes involved in active DNA demethylation through stepwise oxidation of 5mC. However, oxidation pathways of TET enzymes in the symmetrically methylated CpG context are still elusive. Employing the unique fluorescence properties of pyrene group, we designed and synthesized a sensitive fluorescence-based probe not only to target 5-formylcytosine (5fC) sites, but also to distinguish symmetric from asymmetric 5fC sites in the double stranded DNA context during TET-dependent 5mC oxidation process. Using this novel probe, we revealed dominant levels of symmetric 5fC among total 5fC sites during in vitro TET-dependent 5mC oxidation and novel mechanistic insights into the TET-dependent 5mC oxidation in the mCpG context.
Electrospray Ionization Mass Spectrometric Analyses of Phospholipids from Rat and Human Pancreatic Islets and Subcellular Membranes: Comparison to Other Tissues and Implications for Membrane Fusion in Insulin Exocytosis †

Glucose-induced insulin secretion from pancreatic islets involves hydrolysis of arachidonic acid from phospholipids as an intermediary event. Accumulation of nonesterified arachidonate in islet membranes may influence both ion fluxes that trigger insulin secretion and fusion of secretory granule and plasma membranes. Recent findings indicate that plasmenylethanolamine species may also participate in fusion of such membranes, but high-performance liquid chromatographic (HPLC) and gas chromatographic/ mass spectrometric (GC/MS) analyses of islet secretory granule phospholipids suggested that they contain little plasmenylethanolamine. Here, electrospray ionization mass spectrometry (ESI/MS) of intact phospholipid molecules is used to demonstrate that the most prominent components of all major glycerophospholipid headgroup classes in islets are arachidonate-containing species. Such species contribute the majority of the ESI/MS negative ion current from rat and human islet glycerophosphoethanolamine (GPE), and the fraction of GPE negative ion current contributed by plasmenylethanolamine species in rat islets is higher than that for rat liver or heart and similar to that for brain. The most prominent sn-2 substituent of plasmenylethanolamine species in brain is docosahexaenoate and in islets is arachidonate. Arachidonate-containing plasmenylethanolamine species are also prominent components of GPE from islet secretory granules and plasma membranes. Fusion of islet secretory granule and plasma membranes is demonstrated to be catalyzed by cytosolic components from insulinoma cells and rat brain with chromatographic similarities to a rabbit brain factor that specifically catalyzes fusion of plasmenyletha- nolamine-containing membranes.
The Federal Response to Crime Victims, 1960-1992

The federal government has responded to the victims' movement by proposing and passing legislation to expand the rights and protection of victims of crime. This study describes the federal activity surrounding victims of crime and traces the history of federal legislation and spending from the Kennedy administration to the Bush administration. It demonstrates that the federal government has become more active in the fight to provide victims with increasing rights, but has done so slowly. The symbolic nature of victims' compensation programs and victim impact statements is also discussed.
On the response of non-dissipative solids

In addition to being incapable of dissipation, in any process that it is subject to, there are other tacit requirements that a classical elastic body has to meet. The class of solids that are incapable of dissipation is far richer than the class of bodies that is usually understood as being elastic. We show that, unlike the case of a classical elastic body, the stress in non-dissipative bodies is not necessarily derivable from a stored energy that depends only on the deformation gradient.
Sub-selective quantization for large-scale image search

Recently with the explosive growth of visual content on the Internet, large-scale image search has attracted intensive attention. It has been shown that mapping high-dimensional image descriptors to compact binary codes can lead to considerable efficiency gains in both storage and similarity computation of images. However, most existing methods still suffer from expensive training devoted to large-scale binary code learning. To address this issue, we propose a sub-selection based matrix manipulation algorithm which can significantly reduce the computational cost of code learning. As case studies, we apply the sub-selection algorithm to two popular quantization techniques PCA Quantization (PCAQ) and Iterative Quantization (ITQ). Crucially, we can justify the resulting sub-selective quantization by proving its theoretic properties. Extensive experiments are carried out on three image benchmarks with up to one million samples, corroborating the efficacy of the sub-selective quantization method in terms of image retrieval.
Anterior thalamic nucleus stimulation for epilepsy

One option for treatment of medically refractory debilitating epilepsy is stimulation of the anterior thalamic nucleus, which projects via the cingulate gyrus to limbic structures and neocortex. In this chapter we describe the technique for anterior thalamic deep brain stimulation and report outcomes of early series of patients. The prospective double-blind randomized Stimulation of the Anterior Nucleus of the Thalamus for Epilepsy (SANTE) trial will evaluate the efficacy of this technique for epilepsy treatment.
Permanent sterilization through a posterior colpotomy.

398 women sterilized by classical methods through a posterior colpotomy provide data on surgical difficulties and early postoperative complications to assist gynecologists in their evaluation of the procedure. Patient selection preoperative and postoperative procedures surgical technique and difficulties effectiveness and complications are detailed. Women in this study ranged from 19 to 48 years with a range in parity of 1-13. Patients had last delivered or aborted a minimum or 6 weeks prior to sterilization. There was a failure in procedure in 2.3%. Surgeons encountered difficulties in performing the procedure in 5.9%. There were potentially serious surgical complications reported for 2.6% of the sterilized patients. Within 6 weeks of sterilization potentially serious postoperative complications were reported for 6.2% of the patients. The incidence of pregnancy after sterilization probably depends more on the method of tubal ligation than on the type of incision. Clinically acceptable rates of effectiveness and complications can be achieved when patients are properly selected when surgeons are experienced and skilled in vaginal surgery and when surgeons are especially cautious to insure hemostasis anbd minimal bacterial contamination.
Goal-based development and the SDGs: implications for development finance

The 193 member states of the United Nations have now adopted the Sustainable Development Goals (SDGs) for the period 2016–30 to follow the Millennium Development Goals (MDGs) that were in effect during 2000–15. The MDGs focused on reducing extreme poverty; the SDGs focus on sustainable development, meaning the holistic achievement of economic development, social inclusion, and environmental sustainability. These goals are valuable in so far as they push the world community to achieve quantified, time-bound objectives. It is fairly easy to declare that we should fight poverty, hunger, and disease, or resist human-induced climate change. Such platitudes are easily stated, and alas, also easily ignored. It is quite a different thing to agree that the world should cut the rate of $1.25-per-day poverty by half between 1990 and 2015 as in MDG 1, or reduce under-5 mortality rates to below 25/1,000 in all countries by 2030 as in SDG 3. It is the quantified, time-bound objectives that force us to think hard, plan in detail, mobilize additional resources, and implement a sound operational strategy. I often hark back to the wise words of President John F. Kennedy: ‘By defining our goal more clearly—by making it seem more manageable and less remote—we can help all peoples to see it, to draw hope from it, and to move irresistibly toward it.’1 That, in essence, is the job of the MDGs and SDGs. Let us define our goal—whether fighting poverty, or hunger, or illiteracy, or human-induced climate change—more clearly. Let us define a manageable path to achieve the goal. And by so doing, let us inspire more people around the world to appreciate the goal and to embrace it. The clarity of purpose helps to mobilize resources, talents, and plans to succeed.
Creativity in design teams: the influence of personality traits and risk attitudes on creative concept selection

Concept selection is recognized as a crucial component of the design process that largely involves informal group discussions within design teams. However, little is known about what factors affect the selection or filtering of creative ideas during this process. This is problematic because in order for innovation to occur, individuals must first identify and select the creative concepts developed in the early stages of design. However, prior research has shown that individuals tend to select conventional alternatives during this process due to the inherent risk associated with creative concepts. Therefore, the current study was developed to understand how personality traits, risk attitudes, and idea generation abilities impact the promotion or filtering of creative ideas in a team setting. The results from our empirical study with engineering students reveal that teams who have higher levels of conscientiousness, agreeableness, and tolerance for ambiguity are more prone to select novel concepts. In addition, the results revealed that the teams who generate creative ideas did not necessarily select creative ideas during concept selection. These results add to our understanding of team-based decision making during concept selection and allow us to provide guidelines for increasing the flow of creative ideas through this process.
Diameter-weight relationships for juniper from wet and dry sites

Height-diameter (basal or canopy) relationships for Juniperus scopulorum trees taken from wet and dry sites were quite different, but total aboveground weight - diameter relationships for trees taken from the two sites did not differ. It is shown that log total weight (kg) = approximately 1.7 + 2.26 log basal diameter (cm) = - 2.55 + 2.98 log canopy diameter (cm). Though the first relationship (r 2 = 0.98) is stronger than the second (r 2 = 0.80), the canopy diameter-weight relationship may be useful for estimating tree weights from aerial photos. Root - shoot ratios for wet site trees 5, 12, and 31 cm in basal diameter were 37, 27, and 26 percent, respectively.
What Causes Lupus Flares

Systemic lupus erythematosus (SLE), the prototypic systemic autoimmune disease, follows a chronic disease course, punctuated by flares. Disease flares often occur without apparent cause, perhaps from progressive inherent buildup of autoimmunity. However, there is evidence that certain environmental factors may trigger the disease. These include exposure to UV light, infections, certain hormones, and drugs which may activate the innate and adaptive immune system, resulting in inflammation, cytotoxic effects, and clinical symptoms. Uncontrolled disease flares, as well as their treatment, especially with glucocorticoids, can cause significant organ damage. Tight surveillance and timely control of lupus flares with judicial use of effective treatments to adequately suppress the excessive immune system activation are required to bring about long term remission of the disease. We hope that new clinical trials will soon offer additional effective and target-specific biologic treatments for SLE.
Deleuze's Cinematic Geophilosophy: Glimpsing Unknown Worlds and Durations Through the Camera Eye

How can cinema and art help us to think ecologically? This question is examined through an analysis of Deleuze's Cinema 2: The Time-Image and What is Philosophy? This paper argues that cinema and art produce new sets of relations that enable us to map the world beyond human space and to glimpse an image of time, inhabited by multiple nonhuman worlds, sensations and durations. Humanity is constantly transformed through the machines it creates and the human body becomes a different machine every time it encounters the work of art or the cinematic apparatus. Thus the paper experiments with new philosophical concepts that express the life of nonhuman time and sensation that cinema and art enable us to perceive. It also seeks ways to nurture a capacity to intuit nonhuman modes of duration and to cultivate presumptive generosity towards styles of temporality not immediately present to us.
Abstract 4432: MMP9 reinforces radiation-induced delayed invasion and metastasis of neuroblastoma through second-signaling positive feedback with NFκB via both ERK and IKK activation.

Proceedings: AACR 104th Annual Meeting 2013; Apr 6-10, 2013; Washington, DC Tumor recurrences continue to remain high in neuroblastoma (NB), and a substantial fraction of those develop metastatic disease with only 10% survival in systemic recurrences. Efficient and improved therapeutic strategy can be developed through targeted drug delivery approach and by intervening molecular pathways operating in response to tumor recurrence. Herein, we investigated the onset and maintenance of metastatic signal transduction in neuroblastoma (SH-SY-5Y, MC-IXC, SK-PN-DW and IMR-32) cells that survive after radiotherapy. Gelatin zymography revealed that exposure to radiation induces significant and consistent increase in MMP2 and MMP9 activity. Further, muting radiation induced NFκB with dominant negative mutant IkB and/or forced expression of NFκB (p50/p65 sub-units) in these cells affirmed the influence of radiation-induced NFκB in MMP9 transactivation (QPCR), translation (immunoblotting) and activity (sequence specific substrate based high sensitive fluorogenic assay). Interestingly, blocking radiation-induced MMP9 with GM-6001 profoundly inhibited p65 transactivation and nuclear localization. More importantly, blocking radiation-induced MMP9 greatly introverted radiation-induced phosphorylation of IKK in these cells. Furthermore, radiation increased both transactivation and activity of ERK-1 (active ERK/phosphor-transferase immunoprecipitation) in neuroblastoma cells. This pathway was further defined (MMP9 blocking and activation, PMA studies) to show that radiation-induced functional MMP9 is necessary for activation of ERK- and NFκB-dependent onset of metastasis (tumor invasion and metastasis transcriptome profiling) in surviving NB cells. Selective MMP9-dependent ERK regulation was confirmed with futile inhibition of ERK activity in aprotinin treated cells. Together, these data strongly suggest that radiation induced NFκB-dependent MMP9 reinforces radiation-induced delayed invasion and metastasis. Further, these results imply that the MMP9 dependent reinforcement may involve dual signaling feedback activation of NFκB though ERK and IKK phosphorylation. Citation Format: Ryan Major, Sheeja Aravindan, Mohan Natarajan, Terence S. Herman, Natarajan Aravindan. MMP9 reinforces radiation-induced delayed invasion and metastasis of neuroblastoma through second-signaling positive feedback with NFκB via both ERK and IKK activation. [abstract]. In: Proceedings of the 104th Annual Meeting of the American Association for Cancer Research; 2013 Apr 6-10; Washington, DC. Philadelphia (PA): AACR; Cancer Res 2013;73(8 Suppl):Abstract nr 4432. doi:10.1158/1538-7445.AM2013-4432
High-frequency vibration of a conformal antenna structure:

AbstractWhen the functionalities of an antenna and a load-carrying airframe are integrated into a unified structure in an unmanned aerial vehicle, they would affect each other as additional mechanical loading is caused by electromagnetic field. For a low-frequency structural motion, this coupling effect is negligible; for high-frequency vibrations, non-uniform frequency shifts and magnitude variations are predicted.
Partial Thromboplastin Time Reagents: Another Look

Ellagic acid and micronized silica, respectively, are the activating agents in two commonly used commercial partial thromboplastin time reagents. The two reagents were compared for their ability to detect partial deficiencies of clotting factors. The normal ranges for each were first determined using one semiautomated clot-detecting machine. Different clotting factordeficient plasmas were then mixed with varying proportions of a normal plasma pool. The clotting factor level at which the clotting time was prolonged was determined for each reagent. The reagents proved to be equally effective for this purpose.
Volatile single-source molecular precursor for the lithium ion battery cathode.

The first single-source molecular precursor for a lithium–manganese cathode material is reported. Heterometallic β-diketonate LiMn2(thd)5 (1, thd = 2,2,6,6-tetramethyl-3,5-heptanedionate) was obtained in high yield by simple one-step solid-state reactions employing commercially available reagents. Substantial scale-up preparation of 1 was achieved using a solution approach. The crystal structure of the precursor contains discrete Li:Mn = 1:2 trinuclear molecules held together by bridging diketonate ligands. The complex is relatively stable in open air, highly volatile, and soluble in all common solvents. It was confirmed to retain its heterometallic structure in solutions of non-coordinating solvents. The heterometallic diketonate 1 was shown to exhibit clean, low-temperature decomposition in air/oxygen that results in nanosized particles of spinel-type oxide LiMn2O4, one of the leading cathode materials for lithium ion batteries.
R(+)-Baclofen, but Not S(-)-Baclofen, Alters Alcohol Self-Administration in Alcohol-Preferring Rats.

Racemic baclofen [(±)-baclofen] has repeatedly been reported to suppress several alcohol-motivated behaviors, including alcohol drinking and alcohol self-administration, in rats and mice. Recent data suggested that baclofen may have bidirectional, stereospecific effects, with the more active enantiomer, R(+)-baclofen, suppressing alcohol intake and the less active enantiomer, S(-)-baclofen, stimulating alcohol intake in mice. The present study was designed to investigate whether this enantioselectivity of baclofen effects may extend also to the reinforcing properties of alcohol in rats. To this end, selectively bred Sardinian alcohol-preferring (sP) rats were initially trained to lever-respond on a Fixed Ratio (FR) 4 (FR4) schedule of reinforcement for alcohol (15%, v/v) in daily 30-min sessions. Once responding had stabilized, rats were tested with vehicle, (±)-baclofen (3 mg/kg), R(+)-baclofen (0.75, 1.5, and 3 mg/kg), and S(-)-baclofen (6, 12, and 24 mg/kg) under the FR4 schedule of reinforcement. Treatment with 3 mg/kg (±)-baclofen reduced the number of lever-responses for alcohol and estimated amount of self-administered alcohol by approximately 60% in comparison to vehicle treatment. R(+)-baclofen was approximately twice as active as (±)-baclofen: treatment with 1.5 mg/kg R(+)-baclofen decreased both variables to an extent similar to that of the decreasing effect of 3 mg/kg (±)-baclofen. Conversely, treatment with all doses of S(-)-baclofen failed to affect alcohol self-administration. These results (a) confirm that non-sedative doses of (±)-baclofen effectively suppressed the reinforcing properties of alcohol in sP rats and (b) apparently do not extend to operant alcohol self-administration in sP rats the capability of S(-)-baclofen to stimulate alcohol drinking in mice.
INFLUENCE OF ALCOHOL AND AMINE ON VISCOSITY OF HYDROPHOBICALLY ASSOCIATING WATER-SOLUBLE POLYMER SOLUTION

The influence of alcohol (including butanol, dodecanol, tetradecanol) and amine (including n-hexylamine and n-butyl amine) on viscosity of hydrophobically associating water-soluble polymer solution has been investigated in this paper. It has been shown that alcohols can enhance the viscosity of the polymer solution and the more alkyl carbon number of the alcohol the more notably increase of the viscosity of the polymer solution. The viscosity of the polymer solution decreases obviously because of addition of the amine including n-hexylamine and n-butyl amine.
Randomized comparison of efficacy and acceptability of medical versus surgical abortion

Abstract Objective: To compare the clinical efficacy, patient acceptance, and provider resources needed to provide medical and surgical abortion in women with pregnancies up to 49 days gestation. Methods: Women with no pretreatment preference for method of abortion were randomized to medical abortion (group 1: methotrexate 50 mg orally, followed 5–6 days later by misoprostol 800 μg vaginally; the misoprostol dose was repeated if the abortion did not occur) or surgical abortion under local anesthesia using manual vacuum aspiration (group 2). The time spent by clinical staff for all interactions with participants were recorded prospectively. Results: Enrollment of 50 subjects took 24 months. Twenty-three of 25 women (92%, 95% CI 81, 100%) in group 1 and 24 of 25 women (96%, 95% CI 88%, 100%) in group 2 had complete abortions (P = 0.9). The complete abortion rate by study day 15 was 20 of 24 (83%, 95% CI 68, 98%), and 24 of 25 (96%, 95% CI 88%, 100%) for groups 1 and 2, respectively (P = 0.2). Only 63% of women randomized to medical abortion would choose that option again, compared with 92% of women who had a surgical abortion (P = 0.03). Surgical abortion is 3–13% more expensive to provide (from a personnel standpoint) than medical abortion using methotrexate and misoprostol. Conclusions: In women who did not have a preference between medical and surgical abortion, the side effect profile and patient acceptability of medical abortion are inferior to surgical abortion. Medical abortion, even with an increase in the number of office visits, seems to be slightly less costly than surgical abortion.
Lissencephaly Type III Syndrome

Arthrogryposis multiplex congenita (AMC), called fetal akinesia sequence (FAS) in this study of 5 lethal cases, was associated with a distinctive neuropathological pattern, named type III lissencephaly syndrome, as reported from the Hopital Henri Mondor, Creteil, and the Hopitals Port Royal and Saint Antoine, Paris, France.
Computed Tomography of Transverse Phase Space

Two computed tomography techniques are explored to reconstruct beam transverse phase space using both simulated beam and multi-wire profile data in the Fermilab Muon Test Area ("MTA") beamline. Both Filtered Back-Projection ("FBP") and Simultaneous Algebraic Reconstruction Technique ("SART") algorithms [2] are considered and compared. Errors and artifacts are compared as a function of each algorithm’s free parameters, and it is shown through simulation and MTA beamline profiles that SART is advantageous for reconstructions with limited profile data.
Taking Matter Seriously: Material Theopoetics in the Aftermath of Communal Violence

Performance and play with our material world are ubiquitous to the human experience. This chapter explores how matter is made sacred, giving theopoetic witness to and transfiguring our bond with the dead in the aftermath of communal violence. This chapter draws upon a case study of a Boston-based lay-led ministry that works with survivors of homicide for illustration. Practices of material play speak to resilience in the face of trauma and reshape the foundations of our constructive and practical theologies of trauma. When performed and witnessed in the public square, such practices demonstrate the power to transfigure our wounded world, particularly when intercultural dimensions are taken seriously by public theologians of trauma.
In-the-bag nasal intraocular lens optic truncation for treatment of negative dysphotopsia.

We describe in-the-bag nasal intraocular lens (IOL) optic truncation, a new technique for the treatment of negative dysphotopsia. After a plane is created between the nasal capsular bag and the IOL, micrograspers and intraocular scissors are used to amputate the nasal optic edge. The amputation is to reduce the optical impact of the IOL edge and nasal anterior capsule on the occurrence of negative dysphotopsia. The technique addresses many of the proposed mechanisms contributing to the development of negative dysphotopsia and can theoretically be used in all patients with chronic symptomatology. In the case we describe, the dysphotopsia resolved immediately after in-the-bag nasal IOL optic truncation. Financial Disclosure None of the authors has a financial or proprietary interest in any material or method mentioned.
Abstract 1769: Rottlerin induces ER stress-mediated cell death in pancreatic stellate cells

Pancreatic ductal adenocarcinoma (PDAC) is a deadly disease with a 5-year survival rate under 5%. Whereas activated pancreatic stellate cells (PaSC) are important players in PDAC stroma, simultaneously targeting both cancer and stromal cells can be beneficial for cancer therapy. We previously reported that the phytochemical rottlerin dose-dependently reduces PaSC viability through dysregulation of autophagy and induction of apoptosis, and attenuates tumor progression in PDAC experimental models. Interestingly, both rottlerin and metformin have been shown to affect mitochondrial function, and metformin has been demonstrated to induce AMPK-dependent, CHOP-mediated cell death. Here we further studied the mechanisms underlying cell death and autophagy in rottlerin-treated mouse PaSC. Rottlerin rapidly depolarized mitochondrial membrane, increased oxygen consumption and decreased cellular ATP levels and the expression of the mitochondrial transmembrane protein TOM20, suggesting mitochondrial damage. Rottlerin dysregulated autophagy as indicated by rapid and prolonged increasing in LC3I-LC3II conversion and p62/SQSTM1 accumulation. However, rottlerin-induced LC3II did not further change in the presence of inhibitors of autophagic flux, suggesting that rottlerin blocks autophagy progression in PaSC. In addition, rottlerin induced marked AMPK activation and inhibited mTOR signaling. In contrast to metformin, AMPKα1/2 knockdown had no effect on rottlerin-induced inhibition of mTOR signaling and cell viability. Furthermore, rottlerin induced ER stress as manifested by persistent activation of the PERK pathway and upregulation of proapoptotic transcription factor CHOP. Importantly, rottlerin-induced apoptosis was greatly reduced in PaSC isolated from CHOP null mice. In summary, these data indicate that rottlerin reduces PaSC viability through impairing mitochondrial function, inhibiting mTOR signaling and inducing prolonged ER stress. Specifically, CHOP induction plays an important role in determining cell-fate in mitochondria-targeting agents, such as rottlerin and metformin. Citation Format: Hsin-Yuan Su, Richard Waldron, Raymond Gong, Stephen Pandol, Aurelia Lugea. Rottlerin induces ER stress-mediated cell death in pancreatic stellate cells. [abstract]. In: Proceedings of the 106th Annual Meeting of the American Association for Cancer Research; 2015 Apr 18-22; Philadelphia, PA. Philadelphia (PA): AACR; Cancer Res 2015;75(15 Suppl):Abstract nr 1769. doi:10.1158/1538-7445.AM2015-1769
Induction of RNase and nuclease activity in cultured maize endosperm cells following sucrose starvation

The activity of RNases and nucleases in plants often increases following exposure to many types of stress, including prolonged exposure to dark or phosphate starvation. In cereals, the activity of RNases and nucleases is also regulated developmentally during late seed development. In this study, we investigated the effect that the absence of sugar or phosphate in culture medium has on the activity of RNases and nucleases expressed in maize endosperm suspension cells. Withdrawal of sugar from the culture medium resulted in a substantial increase in RNase and nuclease activities, whereas deprivation of phosphate during the same period of growth had no detectable effect on either of these activities. The increase in RNase activity was limited to the neutral RNases, demonstrating that the effect of sugar starvation is specific to one class of RNase. Elimination of asparagine from the medium resulted in a transient reduction in nuclease but not in RNase activity. These observations suggest that sugar starvation constitutes a stress to which maize endosperm responds, in part, by increasing neutral RNase and nuclease activity.
Recent references January through April 1992

In support of a continuing program of systematic evaluation of nuclear structure data, the National Nuclear Data Center maintains a complete computer file of references to the nuclear physics literature. Each reference is tagged by a keyword string, which indicates the kinds of data contained in the article. This master file of Nuclear Structure References (NSR) contains complete keyword indexes to literature published since 1969, with partial indexing of older references. 467 refs. This database record covers the entire volume 66, issue 3, July 1992. The publisher has assigned separate DOIs to each key section of this volume. They are: 1) Recent references January through April 1992, DOI 10.1016/S0090-3752(92)80087-Z; 2) Key numbers and keywords, DOI - 10.1016/S0090-3752(81)80088-2; 3) Reaction Index, DOI 10.1016/S0090-3752(92)80089-3; 4) References, DOI 10.1016/S0090-3752(92)80090-7; 5) Secondary Sources, DOI 10.1016/S0090-3752(92)80011-W.
AR amplification eradication with high-dose testosterone (T) in patients with heavily pretreated mCRPC.

251Background: Patients (Pts) with mCRPC resistant to novel hormones (abi/enza) and taxanes pose a challenge for clinicians. Typically, once these agents are exhausted, clinical trials represent the best therapeutic option; however, many pts are not appropriate for clinical trials due to marrow suppression and/or extensive pre-treatments. Herein we present limited experience with three pts treated with high dose T when therapeutic clinical trial options were not available. Methods: Data was retrospectively collected at Tulane Cancer Center for pt treatment history, laboratory parameters, and circulating free-DNA genomic testing. High dose testosterone was used at a dose of 87.5-100 mg given daily as a 1% testosterone gel applied to the skin. Results: All the mCRPC patients were pre-treated with abi, enza, taxanes, & radium-223. All pts had RBC transfusions due to marrow suppression. All patients were previously treated on clinical trials. After starting high dose T, pt 1 demonstrated a clinical improvemen...
Therapy of Severe Aplastic Anemia With Anti-Human Thymocyte Globulin and Androgens: The Effect of HLA-Haploidentical Marrow Infusion

Fifty-four patients with severe aplastic anemia were treated with horse anti-human thymocyte globulin (ATG) and androgens. Thirty of these patients also received an infusion of HLA-haploidentical marrow cells. Only those patients having evidence of hematologic recovery within 3 mo after ATG therapy were considered responders to the immunosuppressive regimen. Of 53 patients evaluable for response, 21 had complete or partial responses and 7 had minimal improvement by defined criteria. The remaining patients did not respond or died. Factors correlated with response to therapy included a short duration of aplasia and a high admission granulocyte count. Thirty-six patients (66.7%) are surviving between 18 and 43 mo, and 18 have died. Deaths were due to hemorrhage and/or infection. Short duration of aplasia and high granulocyte counts also correlated with survival, as did younger age. Four patients with complete or partial responses had a recurrence of severe aplasia 6–17 mo after their first course of ATG. Three of these patients were retreated with ATG (and oxymetholone in two cases). All three had second responses to therapy, but two of the three have had second relapses. The fourth patient responded to oxymetholone alone, but died after a second relapse. Mismatched marrow infusion had no effect on the incidence of response or survival.
Graves' Ophthalmopathy: A 1987 Update

In the past decade, we have learned that Graves' ophthalmopathy is probably part of a multi-organ autoimmune disease in genetically susceptible individuals. The orbital target tissue is the extraoc...