cssi/SciSciGPT-SciSciNet huggingface dataset:
Characterization of the Pseudomonas aeruginosa alginate lyase gene (algL): cloning, sequencing, and expression in Escherichia coli.

Mucoid strains of Pseudomonas aeruginosa produce a viscous exopolysaccharide called alginate and also express alginate lyase activity which can degrade this polymer. By transposon mutagenesis and gene replacement techniques, the algL gene encoding a P. aeruginosa alginate lyase enzyme was found to reside between algG and algA within the alginate biosynthetic gene cluster at 35 min on the P. aeruginosa chromosome. DNA sequencing data for algL predicted a protein product of ca. 41 kDa, including a 27-amino-acid signal sequence, which would be consistent with its possible localization in the periplasmic space. Expression of the algL gene in Escherichia coli cells resulted in the expression of alginate lyase activity and the appearance of a new protein of ca. 39 kDa detected on sodium dodecyl sulfate-polyacrylamide gels. In mucoid P. aeruginosa strains, expression of algL was regulated by AlgB, which also controls expression of other genes within the alginate gene cluster. Since alginate lyase activity is associated with the ability to produce and secrete alginate polymers, alginate lyase may play a role in alginate production. Images
Infrastructure for the quantum internet

A team of researchers from the Massachusetts Institute of Technology (MIT) and Northwestern University (NU) is developing a system for long-distance, high- delity qubit tele-portation. Such a system will be required if future quantum computers are to be linked together into a quantum Internet. This paper presents recent progress that the MIT/NU team has made, beginning with a review of the teleportation architecture and its loss-limited performance analysis.
Restoring forest herb communities through landscape-level deer herd reductions: Is recovery limited by legacy effects?

White-tailed deer (Odocoileus virginianus) overbrowsing has altered plant species diversity throughout deciduous forest understories in eastern North America. Here we report on a landscape-level (306 km 2 ) project in Pennsylvania, USA that tracked the herbaceous community response to deer herd reductions. From 2001 to 2007, we estimated deer densities, browse impact on woody seedlings, and censused the herbaceous flora in permanent plots throughout the area. We assessed herb layer species richness, abundance, and dominance and measured three known phytoindicators of deer impact: Trillium spp., Maianthemum canadense, and Medeola virginiana. We predicted that browse-sensitive taxa would increase in abundance, size, and flowering as would overall species diversity following deer culls and browse impact that declined by an order of magnitude by 2007. Following intensified deer harvests, we observed a limited recovery of the herbaceous community. Trillium spp. abundance, height, and flowering; M. canadense cover; and M. virginiana height all increased following herd reductions. Similarly, forb and shrub cover increased by 130% and 300%, respectively. Nevertheless, species diversity (i.e., richness and dominance) did not vary. Our work demonstrates that reducing deer densities can provide rapid morphological and population-level benefits to palatable species without a concomitant recovery in diversity. We suggest that decreasing deer populations alone may not promote plant diversity in overbrowsed, depauperate forests without additional restoration strategies to mitigate a browse-legacy layer dominated by browse-resistant species.
Redundancy, the Discrete Fourier Transform, and Impulse Noise Cancellation

The relationship between the discrete Fourier transform and error-control codes is examined. Under certain conditions we show that discrete-time sequences carry redundant information which then allow for the detection and correction of errors. An application of this technique to impulse noise cancellation for pulse amplitude modulation transmission is described.
During hormone depletion or tamoxifen treatment of breast cancer cells the estrogen receptor apoprotein supports cell cycling through the retinoic acid receptor α1 apoprotein

Current hormonal adjuvant therapies for breast cancer including tamoxifen treatment and estrogen depletion are overall tumoristatic and are severely limited by the frequent recurrence of the tumors. Regardless of the resistance mechanism, development and progression of the resistant tumors requires the persistence of a basal level of cycling cells during the treatment for which the underlying causes are unclear. In estrogen-sensitive breast cancer cells the effects of hormone depletion and treatment with estrogen, tamoxifen, all-trans retinoic acid (ATRA), fulvestrant, estrogen receptor α (ER) siRNA or retinoic acid receptor α (RARα) siRNA were studied by examining cell growth and cycling, apoptosis, various mRNA and protein expression levels, mRNA profiles and known chromatin associations of RAR. RARα subtype expression was also examined in breast cancer cell lines and tumors by competitive PCR. Basal proliferation persisted in estrogen-sensitive breast cancer cells grown in hormone depleted conditioned media without or with 4-hydroxytamoxifen (OH-Tam). Downregulating ER using either siRNA or fulvestrant inhibited basal proliferation by promoting cell cycle arrest, without enrichment for ErbB2/3+ overexpressing cells. The basal expression of RARα1, the only RARα isoform that was expressed in breast cancer cell lines and in most breast tumors, was supported by apo-ER but was unaffected by OH-Tam; RAR-β and -γ were not regulated by apo-ER. Depleting basal RARα1 reproduced the antiproliferative effect of depleting ER whereas its restoration in the ER depleted cells partially rescued the basal cycling. The overlapping tamoxifen-insensitive gene regulation by apo-ER and apo-RARα1 comprised activation of mainly genes promoting cell cycle and mitosis and suppression of genes involved in growth inhibition; these target genes were generally insensitive to ATRA but were enriched in RAR binding sites in associated chromatin regions. In hormone-sensitive breast cancer, ER can support a basal fraction of S-phase cells (i) without obvious association with ErbB2/3 expression, (ii) by mechanisms unaffected by hormone depletion or OH-Tam and (iii) through maintenance of the basal expression of apo-RARα1 to regulate a set of ATRA-insensitive genes. Since isoform 1 of RARα is genetically redundant, its targeted inactivation or downregulation should be further investigated as a potential means of enhancing hormonal adjuvant therapy.
Genomic sequencing in clinical trials

Human genome sequencing is the process by which the exact order of nucleic acid base pairs in the 24 human chromosomes is determined. Since the completion of the Human Genome Project in 2003, genomic sequencing is rapidly becoming a major part of our translational research efforts to understand and improve human health and disease. This article reviews the current and future directions of clinical research with respect to genomic sequencing, a technology that is just beginning to find its way into clinical trials both nationally and worldwide. We highlight the currently available types of genomic sequencing platforms, outline the advantages and disadvantages of each, and compare first- and next-generation techniques with respect to capabilities, quality, and cost. We describe the current geographical distributions and types of disease conditions in which these technologies are used, and how next-generation sequencing is strategically being incorporated into new and existing studies. Lastly, recent major breakthroughs and the ongoing challenges of using genomic sequencing in clinical research are discussed.
Layerwise Laminate Analysis of Functionally Graded Piezoelectric Bimorph Beams

A layerwise finite element formulation developed for piezoelectric materials is used to investigate the displacement and stress response of a functionally graded piezoelectric bimorph actuator. The formulation is based on the principles of linear thermopiezoelectricity and accounts for the coupled mechanical, electrical, and thermal responses of piezoelectric materials. The layerwise laminate theory is implemented into a linear beam element in order to provide a more accurate representation of the transverse and shear effects that are induced by the increased inhomogeneities introduced through-the-thickness by the functionally graded materials. The accuracy of the formulation is verified with previously published experimental results for a piezoelectric bimorph actuator. Additional studies are conducted to analyze the impact of electric and thermal loads on the deflections and stresses in a bimorph actuator. Results of the study help to demonstrate the capability of the layerwise theory to provide a more ...
Gastrointestinal stromal tumors. A review of characteristics morphologic, immunohistochemical, and molecular genetic features.

Gastrointestinal stromal tumors are a heterogeneous group of neoplasms composed of either spindled or epithelioid cells that have distinctive histologic appearances and clinical behaviors in different portions of the gastrointestinal tract. These tumors are best evaluated in a site-specific manner, and prediction of clinical behavior is best achieved by evaluation of multiple characteristics, including cell type, cellularity, nuclear pleomorphism, mitotic counts, and the presence or absence of mucosal invasion and tumor cell necrosis. The vast majority of these tumors can be reliably placed into benign or malignant categories using a constellation of morphologic features. Almost two thirds of these tumors arise in the stomach, and slightly less than one third occur in the small bowel. The remaining tumors arise (in descending order of frequency) in the anorectum, large bowel, and esophagus. These tumors uniformly express CD117, and mutations of the c-kit gene are central to their pathogenesis and likely the key to effective therapeutic intervention. Perhaps no other area in surgical pathology has caused as much confusion and controversy as has the subject of gastrointestinal stromal tumors (GISTs). These tumors are a heterogeneous group of neoplasms, and prediction of clinical behavior requires a multiparametric evaluation of gross and microscopic features. However, the same criteria for malignancy do not apply to stromal tumors from different sites within the gastrointestinal tract, and the relative importance of each of these features is somewhat controversial. In the past, cellular spindle cell neoplasms of the gastrointestinal tract have often been referred to as leiomyoma or leiomyosarcoma, based on their purported morphologic resemblance to smooth muscle tumors in other anatomic sites. With the advent of electron microscopic and immunohistochemical analyses, an enormous number of publications attempted to analyze the characteristics of the constituent cells of these tumors. While a number of studies suggested that these tumors were either derived from or differentiated toward smooth muscle, an equal number of studies suggested neural derivation or differentiation. As discussed herein, more recent evidence suggests that the vast majority (if not all) of these tumors are either derived from or differentiate toward the interstitial cells of Cajal (ICCs). The noncommittal term gastrointestinal stromal tumor has been adopted to describe this heterogeneous group of neoplasms and currently is the term of preference. Although a wide array of mesenchymal tumors may arise within the gastrointestinal tract, GISTs are by far the most common mesenchymal tumors of this site.
Safe Houses and Green Architecture: Reflections on the Lessons of the Chemically Sensitive

Abstract Multiple chemical sensitivity (MCS) is a controversial condition involving heightened sensitivities to chemicals and allergens. Retreating to “safe” environments is the best available therapy, making the dwellings of those with MCS compelling studies of healthful design. Safe environments have been offered as exemplars of “green” architecture and have been parodied so as to ridicule environmental concern. In both cases, real lessons are obscured. Reflecting on a study of dwellings built by people with MCS, this essay seeks to clarify the relationship of these unique constructions to ecologically minded architecture as a whole. The dialogue between safe and green points towards their synthesis.
Coordinate Regulation of the Escherichia coli Formate Dehydrogenase fdnGHI and fdhF Genes in Response to Nitrate, Nitrite, and Formate: Roles for NarL and NarP

Escherichia coli possesses three distinct formate dehydrogenase enzymes encoded by the fdnGHI, fdhF, and fdoGHI operons. To examine how two of the formate dehyrogenase operons (fdnGHI and fdhF) are expressed anaerobically in the presence of low, intermediate, and high levels of nitrate, nitrite, and formate, chemostat culture techniques were employed with fdnG-lacZ and fdhF-lacZ reporter fusions. Complementary patterns of gene expression were seen. Optimal fdhF-lacZ expression occurred only at low to intermediate levels of nitrate, while high nitrate levels caused up to 10-fold inhibition of gene expression. In contrast, fdnG-lacZ expression was induced 25-fold in the presence of intermediate to high nitrate concentrations. Consistent with prior reports, NarL was able to induce fdnG-lacZ expression. However, NarP could not induce expression; rather, it functioned as an antagonist of fdnG-lacZ expression under low-nitrate conditions (i.e., it was a negative regulator). Nitrite, a reported signal for the Nar sensory system, was unable to stimulate or suppress expression of either formate dehydrogenase operon via NarL and NarP. The different gene expression profiles of the alternative formate dehydrogenase operons suggest that the two enzymes have complementary physiological roles under environmental conditions when nitrate and formate levels are changing. Revised regulatory schemes for NarL- and NarP-dependent nitrate control are presented for each operon.
Defining, discovering and developing personal leadership in organizations

Personal leadership is an important factor in today’s organizations. This type of trailblazing activity is the backbone of total quality management and team‐based operations. Personal leadership also can replace the middle management expertise lost through downsizing. Presents a generalized process for defining, discovering and developing personal leadership in today’s organizations. Summarizes the definition of personal leadership through the metaphor of trailblazing. Other cognates of the verb “to lead” are defined and examined. The detection of personal leadership in the workforce is made by 360‐degree performance evaluations. Uses survey findings to support activities and skills associated with personal leadership. The development of personal leadership is fostered by rewards, recognition and refocused training.
Mentoring, boundaries, and multiple relationships: opportunities and challenges

Most students and early career professionals desire mentoring relationships. Mentors can provide numerous added benefits to their proteges beyond what they typically obtain from classroom and other formal training experiences. Yet, despite the many potential benefits of mentoring relationships, the very nature of successful mentoring relationships brings with it certain risks for participants. Issues of boundaries and multiple relationships must be understood and successfully navigated to help ensure that mentors’ objectivity and judgment are not impaired and that proteges are not exploited or harmed. The concepts of boundaries, boundary crossings, boundary violations, and multiple relationships are explored in this article and applied in the context of mentoring relationships. Recommendations for successfully navigating the challenges they bring are made in the hope of helping to ensure productive and healthy mentoring relationships.
Ambulatory versus casual blood pressure in the diagnosis of hypertensive patients.

Recent advances in medical technology have enabled the development of fully automatic portable noninvasive blood pressure recorders which can reliably monitor changes of blood pressure over periods of 24 hour or more. The commercial availability of such recorders raises the question of their relevance to the practical management of hypertensive patients.The rationale for the use of Ambulatory Blood Pressure monitoring (ABPM) is the enormous variability of blood pressure. This has been amply demonstrated with both invasive and noninvasive ABPM, and is not a matter of dispute (1,2). Since the adverse effects of blood pressure on the circulation are thought to depend either on the average level of pressure over time or possibly also on the peak levels of pressure, there is a sound theoretical reason for thinking that multiple measurementspage missing 258-258
An Exploration-Estimation Algorithm for Synthesis and Analysis of Engineering Systems Using Minimal Physical Testing

We describe a new general algorithm for the automated design, analysis and repair of nonlinear physical systems. The process iterates a two-phase exploration-estimation cycle. The exploratory phase seeks a new improvement or test to perform to the system based on some initial internal model. The estimation phase performs the suggested operation and observes the outcomes; it then improves the internal model so as to explain all observations so far. This process relies on very few, targeted, and carefully planned interactions with the physical systems. We describe an implementation of this method using two evolutionary algorithms, where the exploratory phase uses a simulator to evolve improvements or tests, and the estimation phase uses observations to evolve the simulator itself. We demonstrate this algorithm for analysis, design and repair of electromechanical systems.
Analytic radiative-advective equilibrium as a model for high-latitude climate

We propose radiative-advective equilibrium as a basic-state model for the high-latitude atmosphere. Temperature profiles are determined by a competition between stabilization by atmospheric shortwave absorption and advective heat flux convergence, and destabilization by surface shortwave absorption. We derive analytic expressions for temperature profiles, assuming power law atmospheric heating profiles as a function of pressure and two-stream windowed-gray longwave radiative transfer. We discuss example profiles with and without an atmospheric window and show that the sensitivity of surface temperature to forcing depends on the nature of the forcing, with greatest sensitivity to radiative forcing by increased optical thickness and least sensitivity to increased atmospheric heat transport. These differences in sensitivity of surface temperature to forcing can be explained in terms of a forcing-dependent lapse-rate feedback.
Accuracy of Cited References: The Role of Citation Databases

The nature and extent of errors made by Science Citation Index Expanded TM (SCIE) and SciFinder ® Scholar TM (SFS) during data entry have been characterized by analysis of more than 5,400 cited articles from 204 randomly selected cited-article lists published in three core chemistry journals. Failure to map cited articles to target-source articles was due to transcription errors, target-source article errors, omitted cited articles, and reason unknown. Mapping error rates ranged from 1.2 to 6.9 percent. SCIE and SFS also were found to correct errors made by authors in cited-article lists roughly one-half and one-sixth of the time, respectively.
Analysis of pathogens isolated constitution and drug resistance of nurseling diarrhea in Hangzhou area

Objective To understand the pathogen constitution and drug resistance of pathogens isolated from patients with diarrhea of nurseling infection in Hangzhou area. Methods Collecting the fresh stool of patients with diarrhea of nurseling infection for enrichment,isolation,biochemical dentification,serotyping,PCR independent gene detection and drug sensitivity test. Results A total of 40 intestinal pathogenic bacteria were isolated among 165 specimens. The positive detection rate was 24. 24%,including diarrheogenic Escherichia coli 31 cases( 18. 79%); Salmonella 6 cases( 3. 64%); Yersinia enterocolitica 2 cases( 1. 21%); Serratia marcescens 1 case( 0. 61%). Intestinal pathogenic bacteria was generally resistant to nalidixic acid,ampicillin,tetracycline,doxycycline and other antibiotics. Conclusion Diarrhoeagenic Escherichia coli was the leader of pathogens of nurseling diarrhea in Hangzhou area; Escherichia coli,Salmonella are resistant to nalidixic acid,ampicillin,tetracycline drugs as common,and lower drug resistance of fluoroquinolone,amoxicillin / rods acid,aminoglycoside; It is important to monitor pathogens isolated constitution and drug resistance andthe rational use of antibiotics.
Automated Generation of Plausible Agent Object Interactions

To interact in a virtual environment, an agent must be aware of its available actions and the objects that can participate in these actions. Work such as Kallmann’s SmartObjects allows for this information to be encoded by a simulation author, but these encodings tend to be constrained to individual graphical models. Furthermore, there may not be agreement on the proper operational information between simulation authors. To create consistent object operational information, we have devised a method that uses natural language lexical databases to parse and assemble this information. The method uses a two step process: 1. The names of motion clips are disambiguated using their name and a list of keywords; 2. Objects are connected to the actions by resolving the operational elements of a given verb. This method is tested on several common, publicly available action sets and the accuracy and coverage of our method are measured.
Lymphoedema is a potential sequela of kaposiform haemangioendothelioma

We read the recent letter by Boccara et al. with great interest. They describe the case of a single infant with Kaposiform hemangioendothelioma (KHE) complicated by Kasabach-Merritt Phenomenon (KMP) who was successfully treated with sirolimus and developed lymphoedema of the affected limb 9 months into therapy. They do not describe any further steps taken at that time; it would be important to know if they adjusted dosing or held sirolimus, and how this affected the lymphoedema. They go on to speculate that lymphoedema was the result of the sirolimus therapy itself. This article is protected by copyright. All rights reserved.
The Evolving E-Business Enterprise Systems Suite

Enterprise systems have emerged recently as a popular approach to outsourcing major application development. In the 1990s, enterprise systems encompassed and integrated core business functions such as manufacturing, logistics, financials, and human resources. During this time, the basic objective of these systems was on streamlining and standardizing information flows and processes. These systems were designed based on the need to optimize the processing of huge numbers of business transactions regularly in an enterprise. As the Internet evolved there has been a greater emphasis on supporting inter-organizational processes. As technologies continue to advance and users become more sophisticated, a greater opportunity to incorporate higher-level decision making tools and capabilities into enterprise systems packages arises. This chapter provides a review of several core areas currently being developed. The view This chapter appears in the book, Intelligent Enterprises of the 21st Century, edited by Jatinder Gupta and Sushil Sharma. Copyright © 2004, Idea Group Inc. Copying or distributing in print or electronic forms without written permission of Idea Group Inc. is prohibited. 701 E. Chocolate Avenue, Suite 200, Hershey PA 17033-1240, USA Tel: 717/533-8845; Fax 717/533-8661; URL-http://www.idea-group.com IDEA GROUP PUBLISHING The Evolving e-Business Enterprise Systems Suite 107 Copyright © 2004, Idea Group Inc. Copying or distributing in print or electronic forms without written permission of Idea Group Inc. is prohibited. of the authors is that enterprise systems as they are evolving today will serve as the foundation for the intelligent enterprise of the 21 century. The last section provides a perspective on how firms should view these systems and their many challenges.
CHAPTER 8 – Receptors and Signaling for Calcium Ions

This chapter discusses the molecular mechanism(s) underlying the process of extracellular ionized calcium concentration (Ca ◦ 2+ ) sensing particularly as related to the maintenance of Ca ◦ 2 + . The extracellular ionized calcium concentration serves as a versatile extracellular first messenger that regulates numerous processes in addition to those involved in maintaining near constancy Ca ◦ 2 + via interaction with specific calcium-sensing receptors on the cell surface. There is interaction among various homeostatic systems crucial for the successful adaptation of complex life forms to the terrestrial environment –such as those regulating water and fuel/nutrient metabolism in which the calcium sensing receptor (CaSR) likely participates, thereby providing new insights into the physiology of mammals and other free-living terrestrial organisms. This chapter also addresses the emerging relationships between ionized calcium concentration homeostasis and other physiologic regulatory mechanisms. However, much remains to be learned about the functions of the CaSR in these tissues as well as in numerous other CaSR expressing cell types that are not directly involved in systemic mineral ion homeostasis.
Enhancing broadcast operations in ad hoc networks with two-hop connected dominating sets

We introduce the three-hop horizon pruning (THP) algorithm to make broadcast operations more efficient in ad hoc networks using contention-based MAC protocols. THP builds a two-hop connected dominating set (TCDS) of the network, which is a set of nodes such that every node in the network is within two hops from some node in the dominating set. Efficiency of broadcast operations is attained by implementing forwarding schemes that take advantage of a TCDS. More specifically, every node provides its one-hop neighbors with a list specifying one or more tuples, each with the identifier of a one-hop neighbor and a bit indicating if that neighbor dominates any two-hop neighbor. To forward a broadcast packet, a node tries to obtain the smallest subset of forwarders, which are one-hop neighbors that use some of the node's two-hop neighbors to reach any node that is three hops away. After such a selection of forwarders, the node broadcasts its packet with a header specifying the list of forwarders, and each forwarder in turn repeats the process.
NF-Ya Is Essential for Hematopoieic Stem Cell Proliferation.

Abstract Abstract 1507 Poster Board I-530 Proliferation, self-renewal and differentiation of hematopoietic stem cells (HSCs) must be tightly regulated in order to sustain hematopoiesis over a lifetime and to prevent uncontrolled expansion of cells. Several genes have been implicated in the regulation of HSC behavior, such as HoxB4, Notch1, Lef-1 and others. Previous studies from our and other laboratories have demonstrated that the heterotrimeric transcription factor NF-Y is a potent inducer of many of these regulatory genes by over-expressing NF-Ya, the regulatory subunit of NF-Y. Furthermore, Bhattarchaya et al. showed that the deletion of NF-Ya in mice leads to lethality before day E8.5, highlighting its importance in mouse development. While there is no doubt that NF-Y plays a role in the progression of the cell cycle in vitro, different groups – targeting different subunits for deletion or silencing – have obtained different results. In order to comprehensively investigate the in vivo function of NF-Y in the hematopoietic system, we utilized a conditional knockout mouse model. We found that the bone marrow (BM) cellularity decreases sharply starting as soon as one day after the ablation of NF-Ya. Our data indicate that the cell loss can be attributed to a combination of cell cycle arrest in G2/M-phase of the cell cycle and apoptosis at 24 hours after the gene deletion. Since NF-Y has been identified as a master regulator of genes involved in HSCs behavior, we focused on the effects of the NF-Ya deletion within the HSC compartment. We found a down regulation of HoxB4, Notch-1, Lef-1 and Bmi-1 following NF-Ya deletion. However, 24h after induction of NF-Ya deletion the HSC population appeared unaffected and their numbers remained stable, likely due to their predominantly quiescent status. To investigate the capability of stem cells to progress though the cell cycle, we activated HSCs using the interferon inducer poly IC and observed that, once activated, also HSCs accumulate in the G2/M-phase of the cell cycle. Finally, to test whether the deletion of NF-Ya impairs or absolutely abrogates HSC function, we performed long term experiments including competitive BM transplantation and colony formation assays that demonstrate that NF-Y activity is absolutely essential for HSC function. Altogether, our data identify NF-Y plays a pivotal role in the survival of hematopoietic cells and the progression of cells though the G2/M-phase of the cell cycle in vivo. Additionally, while we found that NF-Y ablation leads to reduced expression of many genes important for HSC behavior, this had no immediate effects on the maintenance of these cells due to their quiescent nature. Disclosures No relevant conflicts of interest to declare.
D meson nuclear modification factor and v n harmonics in PbPb collisions at 5.02 TeV with CMS

Abstract The measurement of heavy flavor production is a powerful tool to study the properties of the high-density QCD medium created in heavy-ion collisions as heavy quarks are sensitive to the transport properties of the medium and may interact with the QCD matter differently from light quarks. In particular, the comparison between the nuclear modification factors ( R AA ) of light- and heavy-flavor particles provides insights into the expected flavor dependence of in-medium parton energy loss. Furthermore, azimuthal anisotropy coefficients ( v n ) of heavy-flavor particles provide insights into the degree of the thermalization of the bulk medium at low p T , and unique information about the path length dependence of heavy quark energy loss at high p T . Using the large pp and PbPb samples collected at 5.02 TeV during the 2015 LHC run, high precision open charm measurements are performed with the CMS detector in a wide transverse momentum range. This allows us to set an important milestone in our understanding of the interactions between charm quarks and the medium. In this talk, the most recent results of the R AA , v 2 and v 3 of prompt D 0 mesons in PbPb collisions at 5.02 TeV are presented and compared to the same results for charged particles (dominated by light flavor hadrons) at the same energy.
Catalyst enhancing aluminum titanate for increasing strength of nickel-zirconia cermets

Abstract Aluminum titanate (ALT), a catalyst-enhancing phase in nickel-zirconia SOFC anodes, has been observed to have the secondary benefit of increasing flexure strength. Ni-YSZ cermet discs doped with 5 wt% ALT exhibit 150% of stress at failure of non-doped samples in equibiaxial flexure tests. Also observed is a ∼25% increase in toughness, which may be related to the localized introduction of tetragonal zirconia, or alternatively, that the sintering enhancement effect of ALT yields modified flaw geometry at cermet interfaces. Comparison of non-doped and doped Ni-YSZ σ 50% values indicates that the thickness of ALT enhanced anodes could be reduced by ∼20% while maintaining the flexural strength of an unmodified anode.
An Evaluation of New York City's 2015 Birth Certificate Gender Marker Regulation

Abstract Purpose: In 1971, the New York City (NYC) Department of Health and Mental Hygiene amended Section 207.05 of the NYC Health Code to allow individuals who had undergone “convertive surgery” ...
Correction to: The sequence of disease-modifying therapies in relapsing multiple sclerosis: safety and immunologic considerations.

Unfortunately, the online published article has errors in Table 2. The Peginterferon is listed as IM, when it should be SC.
Using the PVI (People Value Index) Tool to Enhance Project Success

Nearly 68% of all projects are “off the rails or fail” according to CIO.COM. Project failure stems from two fundamental components, decision making capacity and process failure. Every project, no matter how big and global, or small and departmental, will have one thing in common. They will have a project manager to lead the process and team members to assist in the completion. In addition, highly specialized software is often used to track the moving pieces, timelines and expenditures. To aid in the process, Gant Charts, Excel Spreadsheets, Power Point, and off the shelf or proprietary software are used. With all these components, technology and knowledge, projects still have a 68% failure rate. Focusing on people assets may be the key to a successful project. In today’s fast-paced business world, organizations large and small need to take advantage of every asset. Physical assets are relatively easy to assess and apply, but physical assets are a small part of the value of an organization. 80 to 90 % of an organization’s value is in its people assets. A tangible asset can be recognized and listed on the balance sheet. Alternatively, intangible assets are non-physical items (e.g. people, patents, knowledge, and competencies). The problem is managers are not able to easily recognize and articulate the value of intangible assets, including the value of knowledge management initiatives in their organizations (Forsyth, 2007). There are two distinct and complementary tasks that are required to take full advantage of what we call “individual assets” in an organization: the capabilities, competencies, and tacit knowledge possessed by individual employees. They are: determine the assets (people) and apply those assets (people) to the needs of the organization. This article introduces the PVI System (People Value Index) which incorporates the P3 (People Asset, Process Management, Power Execution) components. The article brings attention to understanding information from peoples’ knowledge, understanding the concepts behind the value theory and knowledge management concepts, and introducing the PVI Tool. These combined together; enhance project management success by utilizing tacit and explicit knowledge from project managers.
Thermal Transport is Influenced by Nanoparticle Morphology: A Molecular Dynamics Study

Molecular dynamics simulations were performed to model the interfacial thermal conductance (G) from bare gold nanoparticles (icosahedral, cuboctahedral, and spherical) to a hexane solvent. The computed conductance was found to depend not only on particle shape, but also on the size of the nanoparticles, particularly for nanospheres. These results are compared with conductance out of the planar facets: (111), (100), and (110); all commonly exhibited in small patches on the spherical particles. Undercoordination of the surface atoms and the vibrational density of states in the icosahedra explain some of these observations. The exposed surfaces of icosahedral particles are dominated by (111) facets with 9-coordinated gold atoms. Cuboctahedral particles are dominated by the (100) and (111) facets with 8- and 9-coordinated surface atoms, respectively. The nanospheres approach a constant surface density of 6–9 coordinated sites at large particle sizes, and these surface atoms play a large role in the conductanc...
A Learning Management System-Based Early Warning System for Academic Advising in Undergraduate Engineering

This chapter describes a design-based research project that developed an early warning system for an undergraduate engineering mentoring program. Using near real-time data from a university’s learning management system, we provided academic advisors with timely and targeted data on students’ academic progress. We discuss the development of the early warning system and detail how academic advisors used it. Our findings point to the value of providing academic advisors with performance data that can be used to direct students to appropriate sources of support.
Fostering Students Critical Thinking Skills: Cost Analysis and Budgeting Project Approach

The skill and the propensity for critical thinking are vital attributes for effective decision-making by managers. As educators, we need to promote development of critical thinking skills so that our students can progress toward the highest level of thinking. At this highest stage, decision makers can think independently and arrive at well justifiied judgements.
Fusaric Acid and Pathogenic Interactions of Corn and Non-Corn Isolates of Fusarium moniliforme, a Nonobligate Pathogen of Corn

Fusarium moniliform is a nonobligate parasite of corn, which exists as a complex of closely related fungi from different mating population or biological species. Strains of this fungus isolated from corn, have been determined to belong to mating populations A, although other populations have been isolated from corn. The ultrastructural association of the fungus with corn during growth, and the effects of the host on suppression of disease suppression are reviewed. This fungus enters a relationship with corn cultivars that is not always pathogenic. Pathogenesis is delayed, if it ever occurs. F. moniliforme can exist entirely as an endophyte, systemically colonizing kernels, remaining there until germination upon which the fungus infects the emerging seedlings. The symptomless association persists during the growth cycle of corn, and the resulting endophytic hyphae may be the source of mycotoxin production. The host’s ability to suppress the fungus appears to be related to one class of compounds, the cyclic hydroxamic acids and their decomposition products, which can be catabolized by the fungi of mating population A but not C.
Air Trade: Cultural values, norms and firm participation in morally contested markets

This paper examines the variation in firms’ rates of participation in morally contested markets. Firms in these markets face a constant challenge to balance two competing motivations that underlie ...
Cleveland, Ohio: A land of libraries

C leveland, like the rest of the state of Ohio, is a land rich with libraries. The greater metropolitan area of Cleveland alone is home to about a dozen academic libraries, two phenomenal public library systems, and numerous special libraries associated with our area’s many professional and cultural heritage institutions. This is in addition to our robust state-wide consortia, SearchOhio and OhioLINK, which respectively serve millions of public and academic patrons throughout the state. If you’ll be attending the ACRL 2019 Conference in Cleveland this spring, or even if you’re just passing through our city, you’ll want to check out what this land of libraries has to offer.
Abstract 209: Downregulation of KLF2 in the Endothelium Contributes to the Pathogenesis in LMNA-related Dilated Cardiomyopathy

Background: Mutations in the gene that encodes the nuclear envelope proteins lamin A and C (LMNA) accounts for 6% of all cases of Dilated Cardiomyopathy (DCM). However, the molecular mechanisms tha...
Parent and School-Age Children's Food Preparation Cognitions and Behaviors Guide Recommendations for Future Interventions.

Abstract Objective To investigate parent and child food preparation cognitions and behaviors qualitatively to create recommendations for nutrition programs targeting these audiences. Design Focus groups were conducted in community settings with school-age children (n = 37) and parents (n = 38) in Florida, West Virginia, and New Jersey. Setting Community settings in Florida, West Virginia, and New Jersey. Participants School-age children (n = 37) and parents (n = 38). Phenomenon of Interest Factors influencing food preparation of school-aged children and their parents to inform Social Cognitive Theory-based recommendations. Analysis Content analysis. Results Parents believed that child involvement in meal preparation was important for developing cooking skills, responsibility, and self-esteem, but noted that involvement was limited by time scarcity and concern regarding child safety in the kitchen. Parents recommended having children engage in age-appropriate food preparation activities, such as packing their own snacks. Children echoed parents’ beliefs, stating they would need to know how to cook later in life. Many children acknowledged being a part of meal preparation by setting the table and helping grocery shop. Food preparation's link to improving diet quality was not mentioned by parents or children. To increase involvement, children suggested that parents demonstrate skills, select age-appropriate tasks for them, and reward them for helping. Conclusions and Implications This research provides insight into parents’ and children's food preparation cognitions (eg, beliefs, attitudes) and behaviors and assembles results into recommendations that may guide decisions during nutrition intervention development and potentially improve nutrition intervention.
Cracking the channel hopping sequences in IEEE 802.15.4e-based industrial TSCH networks

Industrial networks typically connect hundreds or thousands of sensors and actuators in industrial facilities, such as manufacturing plants, steel mills, and oil refineries. Although the typical industrial applications operate at low data rates, they pose unique challenges because of their critical demands for reliable and real-time communication in harsh industrial environments. IEEE 802.15.4 based Wireless Sensor-Actuator Networks (WSANs) technology is appealing for use to construct industrial networks because it does not require wired infrastructure and can be manufactured inexpensively. Battery-powered wireless modules easily and inexpensively retrofit existing sensors and actuators in industrial facilities without running cables for communication and power. To address the stringent real-time and reliability requirements, WSANs made a set of unique design choices such as employing the Time-Synchronized Channel Hopping (TSCH) technology that distinguish themselves from traditional wireless sensor networks that require only best effort services. The function-based channel hopping used in TSCH simplifies the network operations at the cost of security. Our study shows that an attacker can reverse engineer the channel hopping sequences by silently observing the channel activities and put the network in danger of selective jamming attacks. To our knowledge, this paper represents the first systematic study that investigates the security vulnerability of TSCH channel hopping in IEEE 802.15.4e under realistic traffic. In this paper, we demonstrate the process of cracking the TSCH channel sequences, present two case studies using publicly accessible TSCH implementations (developed for Orchestra and WirelessHART), and provide a set of insights.
Gerontological nursing: Growth, adaptation and change after John A. Hartford Foundation investments

This article chronicles the John A. Hartford Foundation (JAHF) funded gerontological nursing initiatives 1996-present. These initiatives, in particular BAGNC, were designed to impact the health of older adults through building gerontological nursing capacity by preparing new and retooling current faculty with expert gerontological nursing competencies, preparing new researchers, developing a knowledgeable nurse workforce with competency in gerontological nursing and prepare leaders in academics and health care systems. A description of major programs funded by the Foundation is presented and the impact, adaptation, and change in gerontological nursing resulting from over $86 million in funding awarded to these efforts is examined and intended to inform our way forward. NHCGNE, Legacy Affiliates and partners named in this article continue to innovate and transform healthcare systems as a way forward.
Chapter 7 – Comparative planetary evolution

Publisher Summary This chapter looks at the Earth as a member of the Solar System by comparing it with other planets. As members of the Solar System, the Earth and the Moon must be considered within the broader framework of planetary origin. Considering that the age of the universe is around 15 Ga, the formation of the Solar System at about 4.6 Ga is a relatively recent event. Because it is not possible as yet to observe planetary formation in other gaseous nebulae, a variety of indirect evidence is required to reconstruct the conditions under which the planets in the Solar System formed. Geophysical and geochemical data provide the most important constraints. Most scientists now agree that the Solar System formed from a gaseous dust cloud known as the Solar Nebula, which is also discussed in the chapter. The chapter discusses impact chronology in the inner Solar System, and provides details regarding all the planets of the Solar System.
Sleep disparities in the era of the COVID-19 pandemic highlight the urgent need to address social determinants of health like the virus of racism.

Citation:Jackson CL, Johnson DA. Sleep disparities in the era of the COVID-19 pandemic highlight the urgent need to address social determinants of health like the virus of racism. J Clin Sleep Med....
Frontiers in the Simulation of Dislocations

Dislocations play a vital role in the mechanical behavior of crystalline materials during deformation. To capture dislocation phenomena across all relevant scales, a multiscale modeling framework o...
Maternal Stress Before Conception Is Associated with Shorter Gestation.

Author(s): Mahrer, NE; Guardino, CM; Hobel, C; Dunkel Schetter, C | Abstract: BackgroundStress in pregnancy predicts adverse birth outcomes. Stressors occurring prior to conception may also pose risk for the mother and child. The few published studies on preconception stress test a single stress measure and examine only linear associations with birth outcomes.PurposeGuided by findings in the prenatal stress literature, the current study aimed to (i) identify latent factors from a set of preconception stress measures and (ii) examine linear and curvilinear associations between these stress factors and length of gestation.MethodsStudy 1 utilized a sample of 2,637 racially/ethnically diverse women to develop a measurement model of maternal stress from assessments of seven acute and chronic stress measures. Factor analysis revealed three latent factors representing stressors (life events, financial strain, interpersonal violence, discrimination), stress appraisals (perceived stress, parenting stress), and chronic relationship stress (family, partner stress). Study 2 examined the associations of these three latent preconception stress factors with the length of gestation of a subsequent pregnancy in the subset of 360 women who became pregnant within 4.5 years.ResultsControlling for prenatal medical risks, there was a significant linear effect of stress appraisals on the length of gestation such that more perceived stress was associated with shorter gestation. There was a curvilinear effect of stressors on the length of gestation with moderate levels associated with longer gestation.ConclusionsThese results have implications for research on intergenerational origins of developmental adversities and may guide preconception prevention efforts. Findings also inform approaches to the study of stress as a multidimensional construct.