Blame!
Tags: sci-fi

Plot synopsis:
Killy, a silent loner possessing an incredibly powerful weapon known as a Gravitational Beam Emitter, wanders a vast technological world known as "The City". He is searching for Net Terminal Genes, a (possibly) extinct genetic marker that allows humans to access the "Netsphere", a sort of computerized control network for The City. The City is an immense volume of artificial structure, separated into massive "floors" by nearly-impenetrable barriers known as "Megastructure". The City is inhabited by scattered human and transhuman tribes as well as hostile cyborgs known as Silicon Creatures. The Net Terminal Genes appear to be the key to halting the unhindered, chaotic expansion of the Megastructure, as well as a way of stopping the murderous horde known as the Safeguard from destroying all humanity.
Along the way, Killy meets and joins forces with a resourceful engineer named Cibo and several groups such as a tribe of human warriors called the Electro-Fishers. Cibo and Killy are often pursued by the Safeguard, who view any human without Net Terminal Genes as a threat to be extinguished on sight. Because of the size and nature of The City and the violent lives led by its inhabitants, there are virtually no recurring characters and any alliances made are short-lived.
=== Setting ===
The City is actually a structure that began on Earth. The mechanical beings known as Builders, which move around reforming and creating new landscapes, appear to have begun building without end, creating an enormous structure with little internal logic or coherence. The City appears to be organized into distinct floors, with layers of an unknown material called "the megastructure" between them. Traveling between floors is extremely difficult as the megastructure is almost indestructible and approaching the floor boundaries results in a massive safeguard response. Only a direct Gravitational Beam Emitter blast is known to have been capable of penetrating the megastructure.
The City, and the Builders, were once controlled by the Netsphere and the Authority but they have since lost the power to control the expansion of The City due to the chaotic and insecure manner of its growth. Without intervention by a user with Net Terminal Genes they cannot reestablish control over The City nor the Safeguards, whose original job was to eliminate any humans who try to access the Netsphere without Net Terminal Genes. The Safeguard now attempts to destroy all humans without the Net Terminal Gene as the degradation of The City has corrupted their true goals.
In regards to the scale of the structure, NOiSE, the prequel to Blame!, states in its final chapter that "At one point even the Moon, which used to be up in the sky above, was integrated into The City's structure". It has been suggested by Tsutomu Nihei himself in his artbook Blame! and So On that the scale of The City is beyond that of a Dyson sphere, reaching at least Jupiter's planetary orbit (for a radius of around 5.2 AU, or 778,547,200 km); this is also suggested in scenarios such as Blame! vol. 9, where Killy finds himself having to travel through a room roughly the size of Jupiter (roughly 143,000 km).