crossing96/oncoscreening huggingface dataset:
Interprofessional Team-Based Whole-Course Enteral Nutrition in the Peri-Radiation Therapy Period for Esophageal Cancer.	BACKGROUND: Radiation therapy is the main treatment method for esophageal cancer, but its side effects are not ideal. The interprofessional team (IPT) management model has been widely applied in clinical practice; however, there are few reports on nurse-led IPT-based enteral nutrition intervention strategies for patients with esophageal cancer. OBJECTIVES: A nurse-led, IPT-based, whole-course enteral nutrition intervention was investigated to determine whether it could achieve better nutritional status, quality of life, and treatment efficacy for patients with esophageal cancer. METHODS: A total of 72 patients with esophageal cancer were randomized to control and IPT groups. Nutritional status, quality of life, and treatment efficacy were observed before and after radiation therapy. FINDINGS: Severe malnutrition and grade 3 or higher bone marrow suppression had significantly lower incidence, and the one-year progression-free and overall survival rates of patients were significantly higher in the IPT group than the control group.	esophagus
The role of radiotherapy in small cell carcinoma of the esophagus: a retrospective study.	BACKGROUND: Primary small cell carcinoma of the esophagus (SCCE) is an aggressive carcinoma with a rare incidence. Most patients were diagnosed with stage III-IV and have a poor prognosis. The poor therapeutic outcomes of SCCE reveal the need for more rational therapies. METHODS: We retrospectively reviewed 15,463 patients with esophageal carcinoma from January 2015 to December 2020. 235 (1.52%) patients were pathologically diagnosed with primary SCCE. Clinical characteristics and treatment information were extracted from medical records. All statistical analyses were performed with the SPSS software. Patients were divided into radiotherapy (RT) group and non-RT group. The chi-square test was conducted to analyze the difference in baseline characteristics and propensity score matching (PSM) was used to balance the patient characteristics. Univariate and multivariate analysis was used to identify independent prognostic factors and calculated the estimated hazard ratio (HR) and 95% confidence interval (CI). The Kaplan-Meier method was used to draw survival curves, calculate the median overall survival (OS), and compare prognosis between groups with the log-rank p test. The two-tailed p value less than 0.05 indicated a significant difference. RESULTS: The median OS was 15.2 months (range:13.4-17.1 months). The addition of RT improved median OS from 14.3 months to 16.5 months, but the difference was not statistically significant (p = 0.657). After PSM, the median OS of the RT group was longer than the non-RT group (16.5 months vs. 11.5 months, p < 0.001). Multivariate analysis identified RT (HR: 0.711, 95%CI: 0.533-0.949, p = 0.020), surgery (HR: 0.490, 95%CI: 0.365-0.660, p < 0.001), and smoking history (HR: 1.335, 95%CI: 1.010-1.765, p = 0.042) as independent prognostic factors. Subgroup analysis showed that RT was not a prognostic factor in patients with surgery (p = 0.450), but could significantly improve OS in patients without surgery (HR: 0.585, 95%CI: 0.415-0.824, p = 0.002). Both middle and lower thoracic SCCE patients could benefit from the addition of RT. RT could improve OS regardless of Ki67 expression level. Subgroup analyses also indicated that stage IV, age ≥ 60, no smoking history, pure SCCE, Syn-positive, CgA-positive, CD56-positive patients could benefit from RT. CONCLUSIONS: SCCE patients could benefit from RT, especially those without surgery. Further studies are required for confirmation of the conclusion.	esophagus
Worldwide survey on the transcervical approach for minimally invasive treatment of esophageal cancer: results of questionnaire of the international collaborative group on transCervical Minimally Invasive Esophagectomy.	Minimally invasive esophagectomy has emerged over open surgery, showing important advantages on the short time and comparable oncological outcomes, though concerns persist about pulmonary complications. The avoidance of the thoracic route has shown lower pulmonary complication rates compared to traditional approaches. Since 2015, a novel technique was introduced combining single port transcervical and transhiatal laparoscopic mediastinal dissection for esophageal resection. The procedure is nowadays expanding, following the IDEAL framework stage 2b an international collaborative group has been created to register, standardize the procedure, selection of patients, and assess the outcome, highlighting the need for ongoing discussion and research. A broad questionnaire was sent to all the groups worldwide known to us performing this procedure. Results of this questionnaire are the goal of this manuscript, aiming to present the procedure, experiences, problems, and lessons learned with this procedure. The thirteen respondents currently practicing this technique were categorized based on case volume and experience. Results show varied surgical indications, with higher-volume centers displaying less selectivity. Slightly different surgical approaches were reported, with the left transcervical and abdominal transhiatal dissection being the basis techniques. Surgeons reported high rates of R0 resection and lymph node harvested, low rates of pulmonary complications and anastomotic leaks, but high rates of recurrent laryngeal nerve injuries. The collaborative group aims to align techniques, share experiences, and standardize procedures. Despite concerns about recurrent laryngeal nerve injuries, not different from other total mediastinal lymphadenectomy techniques, the procedure shows promise in reducing pulmonary complications, marking a crucial step toward global acceptance. Future efforts will focus on standardization, comparative studies, and training protocols.	esophagus
Saturated fat exacerbates mitochondrial dysfunction through remodelling of ATP production and inflammation in Barrett's oesophagus compared to monounsaturated fat, particularly in contrast to oesophageal adenocarcinoma.	Obesity-related oesophageal adenocarcinoma (OAC), arising from Barrett's oesophagus (BO), incidence rates are rising coincident with high-fat diets. However, adipose tissue phenotype drives metabolic characteristics. Prior feeding studies demonstrated that obesogenic diets enriched in saturated fatty acids (SFA) induce a more adverse metabolic and pro-inflammatory adipose phenotype, compared to monounsaturated fatty acids (MUFA) enriched high-fat diets, despite equal obesity. We hypothesise that different fatty acids may alter the progression of BO to OAC, wherein SFA may be more pathogenic compared to MUFA. Proteomic analysis shows that SFA, not MUFA, increases fatty acid metabolism, oncogenic signalling, and mitochondrial respiratory chain to a greater extent in BO but not in OAC cells. Cellular metabolic analysis validated proteomic findings to show mitochondrial dysfunction in BO but showed an increase in glycolysis in OAC following SFA treatment compared to MUFA. Additionally, it showed a decrease in mitochondrial ATP production following treatment of SFA in BO and OAC cells. Reduction of SFA intake may be beneficial as a supplementary treatment approach to manage and/or prevent OAC progression.	esophagus
NIR-responsive Cu(2 - x)Se@Fc nanoparticles for photothermal- ferroptosis combination therapy in esophageal cancer.	Esophageal cancer (EC) represents a highly recurrent and aggressive malignancy within the digestive system. However, conventional therapeutic strategies exhibit notable limitations in their clinical applications. Photothermal therapy (PTT), combined with ferroptosis, has attracted considerable attentions, emerging as a promising novel strategy for EC treatment. Therefore, there is a critical need to develop a drug delivery system capable of effectively integrating these two therapeutic approaches. In this work, we report a novel drug delivery system based on ferrocene (Fc), which is mixed with lauric acid (a phase-change material with a melting point around 44 (o)C) and then coated on the surface of Cu(2 - x)Se nanoparticles. The photothermal properties of Cu(2 - x)Se triggers the melting of lauric acid under near-infrared (NIR) laser irradiation, facilitating controlled release of Fc. Following internalization by tumor cells via endocytosis, the synergistic effect of PTT and ferroptosis, triggered by Cu(2 - x)Se@Fc, induced immunogenic cell death, which promoted dendritic cell maturation and cytotoxic T lymphocytes recruitment while decreasing the proportion of regulatory T cells, thereby strengthening the antitumor immune surveillance and improving the therapeutic efficacy of Anti-PD-1 blockade. These findings propose that the NIR-responsive Cu(2 - x)Se@Fc formulation represents a promising and effective strategy with prospecting application for cancer treatment.	esophagus
Platelets and MMP‑9 contribute to esophageal cancer invasion via CD40‑CD154 interactions.	CD40 expression in esophageal cancer (EC) is linked to poor prognosis, although its molecular role remains unclear. The present study explored the function of CD40 in EC progression and metastasis, focusing on its interaction with CD154 and the upregulation of MMP‑9. CD40 expression was confirmed in EC cell lines using quantitative PCR, western blotting, flow cytometry and immunocytochemistry. Functional assays showed that recombinant soluble CD154 stimulation enhanced the migration and invasion of CD40‑overexpressing EC cells without affecting viability. Co‑culture experiments with platelets demonstrated that platelet‑derived CD154 acted on CD40‑overexpressing esophageal cancer cells, leading to upregulation of MMP‑9 secretion, potentially driving tumor invasiveness. Serum analysis of patients who underwent esophagectomy revealed that low MMP‑9 levels were associated with longer survival in pathological Stage I, whereas the opposite trend was observed in stages II‑IV. These findings indicated that CD40 activation enhanced tumor cell invasiveness through MMP‑9 upregulation. This dual role of CD40, enhancing antitumor immunity via its expression on antigen‑presenting cells, while promoting tumor invasiveness through MMP‑9 secretion when expressed on esophageal cancer cells, may complicate immunotherapeutic strategies targeting CD40, as such interventions could inadvertently promote malignancy within the tumor microenvironment.	esophagus
Harnessing Calmodulin-Related Genes to Build a Prognostic Model in Esophageal Squamous Cell Carcinoma for a Comprehensive Analysis of Single-Cell Immune Characteristics and Drug Efficacy.	Calmodulin (CALM) has a bearing on the prognosis of various cancers. However, the prognostic value of CALM in esophageal squamous cell carcinoma (ESCC) remains unelucidated. Differentially expressed genes (DEGs) were screened between normal and tumor groups of TCGA-ESCC sets. The intersection of DEGs with calmodulin-related genes (CRGs) yielded differentially expressed CRGs (DE-CRGs). A prognostic model was established using LASSO Cox regression analysis and multivariate Cox regression analysis. qPCR validated the expression of prognostic feature genes. Analysis of gene expression patterns of different cellular clusters was based on single-cell sequencing data. Lastly, GSEA enrichment, immune infiltration, mutational profiling, drug sensitivity, and molecular docking as well as cellular thermal shift assay (CETSA) were conducted for ESCC patients. A prognosis model with excellent predictive capability was created based on 4 feature genes (ATP2B3, CALB1, KCNQ1, and MYO1G). The qPCR results demonstrated that ATP2B3 and KCNQ1 were significantly downregulated in human ESCC cells, whereas CALB1 and MYO1G were upregulated ( P <0.05). Single-cell analysis uncovered that MYO1G and KCNQ1 were mainly expressed in different cell clusters. Furthermore, this risk model was strongly associated with functional pathway enrichment, immune cell infiltration, and somatic mutations. We also identified AZD-8055 may be potential therapy for ESCC patients. The CETSA experiment demonstrated the existence of a favorable binding thermal stability between AZD-8055 and MYO1G. This research may identify potential biomarkers for predicting the prognosis of ESCC patients.	esophagus
The role of deep hyperthermia in IMRT in elderly patients with esophageal cancer: a retrospective cohort study.	PURPOSE: This study aimed to assess the clinical utility of deep hyperthermia in elderly patients with esophageal cancer(EC) who underwent intensity-modulated radiotherapy(IMRT). PATIENTS AND METHODS: This retrospective analysis included 177 elderly patients with EC who underwent IMRT between 2017 and 2023, 42 of whom had combined deep hyperthermia (HT). Propensity score matching (PSM) was used to balance the covariates between the thermoradiotherapy (HTRT) group and IMRT-alone groups. Treatment outcomes and toxicities were compared between the two groups. We used the Kaplan-Meier method to estimate survival curves and the log-rank test to compare survival curves. Cox multivariate analysis was performed to analyze the prognostic factors in these patients. RESULTS: After PSM (42 patients in each group), the HTRT group had a greater objective response rate (ORR) than the IMRT-alone group (83% vs. 62%, P = 0.028). The HTRT group had less radiotherapy-related toxicity, including a lower incidence of leukopenia (14% vs. 33%, P = 0.040) and RP grade ≥ 2 (P = 0.012). However, the 1-, 2-, and 3-year overall survival (OS) rates and 1-, 2-, and 3-year disease-free survival (DFS) rates were not significantly different (P = 0.730, 0.964). Grade ≥ 2 hypoproteinemia (odds ratio [OR] = 3.798, P = 0.004), radiotherapy dose ≤ 60 Gy (OR = 0.445, P = 0.006), and tumor location in the lower esophagus (OR = 0.387, P = 0.005) were adverse prognostic factors for OS. Hypoproteinemia grade ≥ 2 (OR = 3.676, P < 0.001) was also a crucial prognostic factor for DFS. CONCLUSION: Adding deep hyperthermia to IMRT can improve the ORR in elderly patients with EC. In addition, it significantly reduces radiotherapy-related toxicity. Although this approach does not improve the long-term prognosis, it is still practical and has low toxicity, making it suitable for clinical use.	esophagus
[Analysis of the trend and spatial clustering of esophageal cancer mortality in Shandong Province from 1970 to 2021].	Objective: To describe the distribution characteristics and trends of mortality and spatial aggregation of esophageal cancer in Shandong Province from 1970 to 2021. Methods: The mortality data of esophageal cancer were obtained from the death registration system of Shandong Province and three national all-cause mortality retrospective surveys. The crude mortality rate (CMR) and age-standardized mortality rate (ASMR, the Segi's world standard population) were used to describe the mortality of esophageal cancer. Mortality differential decomposition was applied to quantify the contributions of demographic and non-demographic factors. The death levels of esophageal cancer in different counties (cities and districts) in Shandong Province from 1970 to 1974 and 2020 to 2021 were visualized by the ArcGIS 10.8 software, and global and local autocorrelation analyses were conducted by using the GeoDa 1.12 software. Results: The CMR of esophageal cancer in Shandong Province increased first and then decreased from 1970 to 2021. The CMR of esophageal cancer decreased from 17.59/100 000 in the period of 1970-1974 to 14.32/100 000 in the period of 2020-2021. The ASMR of esophageal cancer decreased from 20.04/100 000 in the period of 1970-1974 to 6.53/100 000 in the period of 2020-2021. Compared with the period of 1970-1974, both demographic and non-demographic factors contributed to the increase in esophageal cancer mortality rate from 1990 to 1992. However, demographic factors continued to contribute to the increase in esophageal cancer mortality rate from 2004 to 2005, 2011 to 2013, and 2020 to 2021, while non-demographic factors contributed to the continuous decrease in esophageal cancer mortality rate. The global autocorrelation analysis results showed that the Moran's I index of ASMR of esophageal cancer in each county (city, district) of Shandong Province from 1970 to 1974 and from 2020 to 2021 were 0.67 and 0.57, respectively. Local autocorrelation analysis showed that there were 19 and 13 areas of high-high clustering of esophageal cancer in the periods of 1970-1974 and 2020-2021, respectively, with 12 overlapping counties (cities, districts). Conclusion: From 1970 to 2021, the CMR of esophageal cancer increases first and then decreases, while the ASMR of esophageal cancer gradually decreases in Shandong Province. The distribution of esophageal cancer mortality has significant spatial aggregation and changes over time.	esophagus
Patterns of Lymph Node Recurrence after Esophagectomy of pT2-3 N0M0 Esophageal Squamous Cell Carcinoma.	"PURPOSE: This study aims to elucidate the distribution patterns of lymph node recurrence (LNR) in patients with pT2-3N0M0 esophageal squamous cell carcinoma (ESCC) following esophagectomy. METHODS: A comprehensive retrospective analysis was conducted on 96 pT2-3N0M0 ESCC patients who experienced postoperative LNR at our institution between January 2010 and August 2019. LNR sites were systematically categorized into cervical, mediastinal, and abdominal regions. Computed tomography imaging was digitally reconstructed to precisely map recurrence locations, followed by rigorous statistical analysis of distribution patterns. RESULTS: The final cohort comprised 96 patients with confirmed LNR, with males constituting 79.2% of the sample and a median age of 61 years. Mediastinal LNR was determined to be the most prevalent (69.8%), followed by cervical (43.8%) and abdominal (33.3%) regions. Cervical recurrences were predominantly identified in lymph node station 104R/L (7.8%), while mediastinal recurrences were predominantly localized to station 106recR (14.5%) and station 105 (10.4%), and abdominal recurrences were concentrated in stations 16a2 (3.6%) and 9 (3.6%). Computerized tomography reconstruction demonstrated a distinctive ""T""-shaped distribution of LNR in the cervical and upper mediastinal regions in proximity to major vascular structures. The primary tumor location was not found to significantly influence LNR distribution patterns (P > 0.05). CONCLUSIONS: LNR in pT2-3N0M0 ESCC predominantly manifests in cervical and upper mediastinal lymph nodes. Administering targeted adjuvant radiotherapy to high-risk patients may be an effective strategy for enhancing therapeutic outcomes. Prospective multicenter studies are warranted to validate these preliminary findings."	esophagus
Definitive chemoradiotherapy combined with anti-PD-1 immunotherapy for inoperable esophageal squamous cell carcinoma: a multicenter real-world study.	Trial no. NCT04821778 registered in ClinicalTrials.gov.	esophagus
Preoperative proton pump inhibitor therapy and anastomotic leak after esophagectomy-a new perspective.	PURPOSE: Proton pump inhibitors (PPIs) are indispensable in the treatment of gastro-esophageal reflux disease and peptic ulcers or for the prevention of stress ulcers after major abdominal surgery. However, long-term PPI therapy leads to several side effects such as delayed gastric emptying and distinct changes in mucosal histology. Therefore, this retrospective study aims to evaluate the impact of preoperative PPI therapy on the anastomotic leak rate after esophagectomy. METHODS: A retrospective, single-center analysis was conducted for all patients treated with esophagectomy and gastric conduit reconstruction between January 2016 and November 2024. Preoperative treatment with PPIs, as well as patient comorbidities, histopathological findings and surgical techniques were noted. Subsequently, a group-wise comparison was carried out for the differences in anastomotic leak rate and postoperative complications in patients with and without preoperative PPI therapy. Finally, a multivariate logistic regression analysis was conducted for the occurrence of anastomotic leak. RESULTS: A total of 229 patients were included in the study. The group-wise comparison revealed a significantly higher rate of anastomotic leaks and postoperative complications in patients with preoperative PPI therapy compared to those without. The multivariate logistic regression analysis indicated a 2.5-fold increased risk of anastomotic leaks in patients with preoperative PPI therapy compared to patients without. CONCLUSION: Preoperative PPI therapy may represent a modifiable risk factor for the development of anastomotic leaks after esophagectomy. Further prospective, interventional studies are necessary to verify the results. TRIAL REGISTRATION: The study was retrospectively registered in the German clinical trial database (Application number DRKS00035536, Registration date 03.12.2024).	esophagus
Indocyanine Green Fluorescence Angiography Versus Visual Assessment for Assessing Perfusion of Gastric Conduit and Esophageal Stump in Post Esophagectomy Patients: A Pilot Randomized Controlled Study.	BACKGROUND AND OBJECTIVE: Anastomotic leak (AL) is a serious complication following esophagectomy and is often linked to poor perfusion of the gastric conduit (GC) and esophageal stump (EC). The aim of this study is to compare the efficacy of intraoperative Indocyanine green fluorescence angiography (ICG-FA) versus visual assessment VA) to assess perfusion status and its impact on the rate of AL. METHODS: Fifty-eight esophageal or gastroesophageal junction carcinoma patients were randomized to ICG-FA (28) and VA (30) groups. Perfusion status was assessed with VA alone in the VA group and with VA followed by ICG-FA in the ICG-FA group. RESULTS: The ICG-FA group had a lower leak rate of 4% when compared to 27% in the VA group (p = 0.03). ICG-FA identified nine cases where VA misjudged the GC tip vascularity, thereby avoiding unnecessary resections. ICG-FA necessitated revision of the GC tip in one case missed by VA and also identified poor perfusion of ES tip in three cases mandating revision which were deemed well-perfused by VA. CONCLUSION: ICG-FA demonstrated superiority over VA in assessing perfusion adequacy of the GC and ES, which resulted in a statistically significant decrease in the rate of anastomotic leaks.	esophagus