crossing96/oncoscreening huggingface dataset:
Comparison of efficacy and safety in two versus three cycles of neoadjuvant immunotherapy plus chemotherapy for esophageal squamous cell carcinoma.	PURPOSE: This research aimed to compare the efficacy and safety in two versus three cycles of neoadjuvant immunotherapy plus chemotherapy for esophageal squamous cell carcinoma. MATERIALS AND METHODS: Patients with esophageal squamous cell carcinoma receiving neoadjuvant immunotherapy plus albumin-bound paclitaxel and platinum-based chemotherapy followed by esophagectomy from December 2020 to May 2024 were retrospectively analyzed. The therapeutic efficacy, adverse reactions, and postoperative complications between the two- and three-cycle groups were analyzed using chi-square test and independent sample t-test. The overall survival (OS) and progression-free survival (PFS) were estimated by the Kaplan-Meier method with log-rank test. RESULTS: A total of 138 esophageal squamous cell carcinoma patients receiving neoadjuvant immunotherapy plus chemotherapy were enrolled. The R0 resection rates were 94.5% and 95.7% in the two- and three-cycle groups, respectively (P = 0.554). The pathological complete response and major pathological response rates in the two-cycle group were 19.8% and 40.7%, while they were 21.3% and 38.3% in the three-cycle group, respectively, with no significant differences (P = 0.836 and P = 0.788). More anemia cases appeared in the three-cycle group (27.7% vs. 13.2%, P = 0.036). There were no significant differences between the two- and three-cycle groups in terms of anastomotic fistula, pulmonary infection, chylothorax, and multiple organ dysfunction syndrome. Additionally, The 3-year OS rates of patients in the two- and three-cycle groups were 80.1% and 74.5%, respectively, without significant difference (P = 0.421). The 3-year PFS rates in the two- and three-cycle groups were 62.5% and 65.8%, respectively, without significant difference either (P = 0.966). CONCLUSIONS: Two-cycle neoadjuvant immunotherapy combined with albumin-bound paclitaxel and platinum based chemotherapy can be an effective, safe, and optional neoadjuvant strategy for esophageal squmous cell carcinoma patients.	esophagus
The dysregulation of UPP1 incurred by METTL3 regulates the malignancy of esophageal squamous cell carcinoma in an m(6)A-YTHDC1-KLF5-mediated manner.	Uridine phosphorylase 1 (UPP1) has been shown to catalyze the generation of ribose derived from uridine, to promote central carbon metabolism, and to collaborate with glucose to drive aerobic glycolysis in tumor cells, thereby playing an oncogenic role in several cancers. However, its correlation with the onset and progression of esophageal squamous cell carcinoma (ESCC) has not been explored. We revealed that UPP1 was highly expressed in ESCC, and that loss of UPP1 impaired the malignancy of ESCC cells in vitro and in vivo. We found that silencing methyltransferase-like 3 (METTL3) reduced m(6)A modification in the 3'-untranslated regions (3'UTR) of Krüppel-like factor 5 (KLF5), which decreased its interaction with YTH N6-Methyladenosine RNA Binding Protein C1 (YTHDC1), and subsequently upregulated the expression of KLF5 by reducing its precursor mRNA (pre-mRNA) levels in ESCC cells. Further study revealed that KLF5 negatively regulated the expression of UPP1 through transcriptional modulation. Our findings establish that the dysregulation of UPP1 in ESCC is modulated by METTL3 in an m(6)A-YTHDC1-KLF5-mediated manner, indicating a potential therapeutic target for ESCC.	esophagus
The impact of transabdominal and transthoracic surgical approaches on prognosis in gastroesophageal junction tumors.	AIM OF THE STUDY: While gastroesophageal junction tumors share some characteristics with both stomach and esophageal cancers, they also exhibit distinct aspects of each. In recent years, these tumors have been regarded as a separate entity. The optimal surgical approach for Siewert type 2 adenocarcinomas is still a subject of debate. This research evaluates the early clinical outcomes and long-term survival associated with transabdominal and transthoracic surgical approaches in patients with Siewert type 2 adenocarcinoma. PATIENTS AND METHODS: This retrospective study analyzes data from patients who underwent surgery for gastroesophageal junction adenocarcinoma from January 2014 to December 2022. Patients diagnosed with Siewert type 2 adenocarcinoma through pathological examination were classified into three categories: Ivor Lewis, total gastrectomy, and proximal gastrectomy. The groups were analyzed for early postoperative morbidity and long-term survival outcomes. RESULTS: The study included 104 patients diagnosed with Siewert type 2 adenocarcinoma. The Ivor Lewis procedure was performed on 27 patients, total gastrectomy on 41 patients, and proximal gastrectomy on 36 patients. The analysis of postoperative complications revealed that transthoracic procedures were markedly associated with the increased occurrence of pulmonary complications. The five-year overall survival rates were 53% (CI: 33.7%-83.4%) for the Ivor Lewis group, 49.3% (CI: 33.9%-71.9%) for the total gastrectomy group, and 60.2% (CI: 43.1%-83.9%) for the proximal gastrectomy group, with no statistically significant differences observed. CONCLUSION: Transabdominal surgical approaches demonstrated a lower incidence of postoperative complications in comparison to transthoracic methods. No significant differences in long-term survival outcomes were observed among the three surgical groups.	esophagus
Latent profile analysis of potential health-promoting behaviors in patients after esophageal cancer surgery: a multicenter cross-sectional survey.	OBJECTIVES: The objectives of this study were to identify potential health-promoting behaviors in patients after esophageal cancer surgery and explore their influencing factors by performing latent profile analysis. METHODS: A convenience sampling method was used to select 438 postoperative patients with esophageal cancer from 14 cancer centers across the country as survey participants. A sociodemographic and disease-related information collection form, the revised version of the Health-Promoting Lifestyle Profile-II, the Social Support Rating Scale, and the Chinese version of the cancer self-efficacy scale were used. A latent profile analysis of potential health-promoting behaviors was conducted, and the factors influencing each category were identified through single-factor analysis and logistic regression analysis. RESULTS: The health-promoting behaviors of patients after esophageal cancer surgery could be divided into three categories: low-level health-promoting behaviors (27.6%, n = 121), medium-level health-promoting behaviors (56.2%, n = 246), and high-level health-promoting behaviors (16.2%, n = 71). The results of logistic regression analysis revealed that age, education level, place of residence, the receipt of neoadjuvant treatment before surgery, the level of social support, and the level of self-efficacy after esophageal cancer surgery were factors influencing health-promoting behaviors (all P < 0.05). CONCLUSIONS: The health-promoting behaviors of patients after esophageal cancer surgery are heterogeneous. Medical staff can perform individualized interventions for patients after esophageal cancer surgery according to the different types of influencing factors to improve their health-promoting behaviors.	esophagus
The global burden and trends of esophageal cancer caused by smoking among men from 1990 to 2021 and projections to 2040: An analysis of the Global Burden of Disease 2021.	INTRODUCTION: Esophageal cancer (EC) ranks 7th globally in cancer mortality, with smoking being a major preventable risk factor, particularly for squamous cell carcinoma predominant in Asia. This study quantifies the global burden of smoking-attributable EC among males using 2021 Global Burden of Disease data (1990-2021) and projects trends to 2040. METHOD: Data on deaths and Disability-Adjusted Life Years (DALYs) for global burden of smoking-attributable EC among males were derived from the Global Burden of Diseases (GBD) Study 2021, along with the corresponding 95% uncertainty intervals (UIs). We analyzed with Joinpoint regression, age-period-cohort modeling for risk stratification, decomposition analysis, and Bayesian prediction. RESULTS: Global smoking-attributable EC deaths and DALYs among males decreased, concentrated in middle-to-high SDI regions. Age-standardized DALY rates (ASDR) declined significantly, with sharpest reductions in medium-SDI regions. East Asia bore disproportionate burden in China and Mongolia. Critical inflection occurred in 2004 by joinpoint and age-period-cohort analysis from 1990 to 2021. Mortality peak at 80-90 years and disability peak at 60-80 years. Decomposition analysis showed population growth and aging increased burden, offset by epidemiological improvements. Predictive analysis indicated stable-to-declining ASRs through 2040, contingent on sustained tobacco control in high-risk regions. CONCLUSION: The analysis indicated a global downward trend in EC attributable to smoking among males. While absolute burdens rise due to demographic pressures, declining ASRs reflect tobacco control progress. The 2004 inflection underscores policy impact, and East Asia's outsized burden necessitates targeted interventions. Our research underscores the profound influence of high BMI on EC attributable to smoking among males and provides a research foundation for future public health decision-making.	esophagus
The crossroads of inflammation and nutrition: predicting neoadjuvant immunochemotherapy efficacy in esophageal squamous cell carcinoma patients.	BACKGROUND: Neoadjuvant immunochemotherapy (nICT) improves outcomes in esophageal squamous cell carcinoma (ESCC); however, patient response heterogeneity limits its clinical benefit. The aim of this study was to investigate the predictive value of the systemic immune-inflammation index and prognostic nutritional index score (SII-PNI score), which is jointly constructed from the systemic immune-inflammation index (SII) and prognostic nutritional index (PNI), for pathological complete response (pCR) and survival outcomes. METHODS: This retrospective study included patients with stage II to IV ESCC who received nICT therapy at Wuhan Union Hospital (WHUH), Fujian Cancer Hospital (FJCH), and 900th Hospital of the Joint Service Support Force of the People's Liberation Army of China (900th Hospital). The predictive performance of SII-PNI score was validated using receiver operating characteristic (ROC) curves. Multivariate logistic regression confirmed SII-PNI score as an independent predictor of pCR. Additionally, Cox regression model and Kaplan-Meier survival curves were employed to analyze disease-free Survival (DFS) and overall survival (OS). RESULTS: A total of 345 patients were included, stratified into 0-score (n = 70), 1-score (n = 149), and 2-score (n = 126) groups. The combined cohort (Combined from FJCH cohort, WHUH cohort, 900th Hospital cohort) area under the ROC curve (AUC) revealed that SII-PNI score (AUC = 0.803) outperformed SII (AUC = 0.679, DeLong's test P < 0.001) and PNI (AUC = 0.667, DeLong's test P < 0.001) in predicting pCR. Compared with 0-score patients, those with 1-score (odds ratio [OR] = 0.159, 95% confidence interval [CI]:0.080-0.319, P < 0.001) and 2-score (OR = 0.025, 95% CI:0.009-0.073, P < 0.001) had significantly lower pCR rates. The 2-score group showed had shorter of DFS (hazard ratio [HR] = 2.487, 95% CI:1.414-4.374, P = 0.002) and OS (HR = 4.473, 95% CI:2.138-9.357, P < 0.001) versus the 0-score group. CONCLUSIONS: This study demonstrated for the first time that the SII-PNI score can be used as an independent predictor of pCR in patients with ESCC treated with nICT and has prognostic stratification value. This suggests that it has the potential to be a pre-treatment assessment tool for evaluating treatment response and prognosis before nICT treatment.	esophagus
Comparison of long-term outcomes of 2.5- and 3-field lymph node dissections for esophageal squamous cell carcinoma.	OBJECTIVES: Previous studies demonstrated that the mesoesophageal suspension technique is safe and effective for thoracoscopic lymph node dissection in esophageal squamous cell carcinoma (ESCC), but direct comparison with 3-field dissection is lacking. This study aimed to compare 2.5- and 3-field lymph node dissections in terms of survival benefits, recurrence patterns, and complications in patients with ESCC. METHODS: This was a retrospective study of patients with ESCC who underwent 2.5- or 3-field lymph node dissection (FLD). The outcomes included 30-day mortality, postoperative complications, overall survival (OS), disease-free survival (DFS), and recurrence pattern. RESULTS: A total of 353 patients with ESCC were included in this study. After propensity score matching, the frequency of all complications (27.8 % vs. 18.3 %, P = 0.072), recurrent laryngeal nerve injury (5.6 % vs. 0.8 %, P = 0.033) and respiratory complications (19.8 % vs. 11.9 %, P = 0.084) was higher in the 3-field group compared with the 2.5-field group. Smaller number of dissected lymph nodes (median, 31.5 vs. 41, P < 0.001) but comparable number of metastatic lymph nodes (median, 0 vs. 1, P = 0.143) was found in the 2.5-field group compared with the 3-field group. The rate of positive supraclavicular lymph nodes was 1.6 % in the 3-field group. There were no differences OS and DFS between the two groups, with median OS and DFS not reached in both groups. Recurrence pattern of all stage patients was similar between the two groups. CONCLUSION: The 2.5- and 3-FLD have comparable survival benefits for patients with ESCC, while the 2.5-FLD has a lower risk of complications.	esophagus
A mediastinal eosinophilic adenoma misdiagnosed as an esophageal stromal tumor: A case report.	BACKGROUND: Eosinophilic adenoma, a benign tumor characterized by eosinophilic cell proliferation, typically arises in endocrine organs such as the thyroid or parathyroid glands. Ectopic parathyroid eosinophilic adenoma is rare and may mimic other mediastinal pathologies, leading to diagnostic challenges. CASE PRESENTATION: We present a case of a 54-year-old woman with a one-year history of dysphagia. Initial imaging and endoscopic studies suggested an esophageal stromal tumor. Thoracoscopic resection revealed a posterior mediastinal mass, later confirmed as an ectopic parathyroid eosinophilic adenoma through histopathological and immunohistochemical analysis. CONCLUSIONS: This case underscores the importance of integrating imaging, laboratory tests, and histopathology for accurate diagnosis of mediastinal masses. Minimally invasive thoracoscopic surgery proved effective for resection, highlighting the need for tailored therapeutic approaches. In order to avoid such misdiagnosis, clinicians should make a definite pathological diagnosis before surgery as much as possible.	esophagus
Exposure to household air pollution in relation to stomach and esophageal cancer in Xuanwei, China.	Household air pollution (HAP) is a global health burden affecting about half of the world's population. In Xuanwei, China, individuals experience high concentrations of various HAP constituents, particularly polycyclic aromatic hydrocarbons (PAHs). Here, the association between HAP constituents and cause-specific mortality from stomach and esophageal cancer was investigated. The study was conducted in a cohort of 42,420 subjects from Xuanwei, China. Participants were followed from 1976 to 2011. Type of fuel used was collected through a questionnaire and categorized into lifetime smoky vs. other fuel use. Annual exposures were predicted for 43 HAP constituents and 5 clusters were identified using hierarchical clustering. Cox regression was used to estimate the association between lifetime smoky coal use and pollutant clusters with stomach (n = 143) and esophageal (n = 39) cancer. All models were stratified by sex and birth cohort and adjusted for smoking status and education. Lifetime smoky coal use (hazard ratio [HR] = 1.40, 95 % confidence interval [CI]: 1.00, 1.96) and a large PAH cluster, PAH37 (HR = 1.59, 95 % CI: 1.19, 2.13 per standard deviation [SD]), were associated with stomach cancer mortality. Similarly, lifetime smoky coal use (HR = 2.84, 95 % CI:1.38, 5.85) and PAH37 (HR = 1.75, 95 % CI: 1.01, 3.04 per SD) were associated with esophageal cancer mortality. Stratified analyses found that the association between PAH37 and stomach cancer was higher among women compared to men (P-interaction = 0.02). This study identified an association between HAP and risk of stomach and esophageal cancer mortality in a highly exposed population. Future work is needed to investigate potential risk differences by timing of exposure.	esophagus
HPV16 Enhances Radiosensitivity in Esophageal Squamous Cell Carcinoma by Promoting De Novo Fatty Acid Synthesis and Disulfidptosis.	Our previous study reported that HPV16 was detected in 48.87% of ESCC patients, which was correlated with better radiotherapy response; however, the underlying mechanisms remained unclear. This study aims to elucidate how HPV16 enhances radiosensitivity through metabolic reprogramming. We overexpressed HPV16-E6/E7 in TE-1 and KYSE-410 cells to establish an in vitro model (denoted as HPV16-positive cells). CCK-8 and colony formation assays showed that HPV16-positive cells exhibited enhanced proliferation and increased radiosensitivity. Using [U-¹³C] glucose tracing, we observed increased de novo synthesis of non-essential fatty acids (C14:0, C14:1, C16:0, C16:1, C18:0, C18:1) in HPV16-positive cells compared to controls. Following 2 Gy X-ray irradiation, the percentage of de novo fatty acid synthesis level was unaffected in HPV16-positive cells, but significantly suppressed in control cells. Irradiation increased the NADP + /NADPH ratio in both cell types. However, [U-¹³C] glucose labeling results showed NADPH consumption rates for lipid acid synthesis were maintained at a high level after irradiation in HPV16-positive cells, while they were reduced significantly in control cells after irradiation. We next inhibited de novo fatty acid synthesis in HPV16-positive cells by palmitic acid (C16:0) supplement, which alleviated the irradiation-induced increase in the NADP + /NADPH ratio and decreased radiosensitivity in HPV16-positive cells. Immunofluorescence analysis revealed that radiation exposure induced F-actin collapse in LV-E6/E7-TE-1 cells, which was accompanied by cystine accumulation and NADPH depletion-disulfidptosis. HPV16 drives high de novo fatty acid synthesis in ESCC cells, which consumes NADPH and leads to disulfide stress-induced cell death, disulfidptosis, enhancing ESCC radiosensitivity.	esophagus
The location and degree of residual disease determines recurrence patterns and survival in patients with esophageal adenocarcinoma after trimodal therapy.	Known predictors of recurrence and survival include the total number of nodes and positive nodes resected, tumor stage, histology, and tumor differentiation. Patients with a complete response have the best survival, but residual tumor in the esophagus, nodes, or both may influence survival. This study assesses the risk of recurrence and survival of esophageal adenocarcinoma after trimodal therapy based upon the location residual disease in the resected specimen. Multicenter, retrospective study of patients with esophageal adenocarcinoma undergoing induction chemoradiation and transthoracic esophagectomy from 2010 to 2017. Overall survival (OS) and recurrence were compared based on the residual disease location using Kaplan-Meier analysis. Clinical factors associated with OS and time to recurrence were also assessed. There were 504 patients with a median follow-up of 63.4 months 95% confidence interval (CI):60.8-70.5 and an estimated overall 5-year survival of 55.8%. When subdivided by residual disease location, the estimated 5-year survival in patients with complete pathologic response and residual disease of only the esophagus was 68.3% and 65.0% hazard ratio (HR) = 1.05; P = 0.81. With increasing nodal positivity there was decreasing survival, 45.8% (N1) and 20.1% (N2). N3 patients did not survive past 36 months. Multivariable analysis demonstrates that any residual disease in the lymph nodes (HR = 3.14), taxane and fluoropyrimidine chemotherapy (HR = 3.34), neoadjuvant radiation dose <50 Gy (HR = 2.35), and fluoropyrimidine chemotherapy (HR = 1.88) were predictive of worse OS. Overall survival and recurrence are influenced by the location of residual disease. Residual disease in the esophagus and pathologic complete response behaves similarly. Survival is reduced as nodal counts increase.	esophagus
A novel nomogram for predicting long-term survival in patients with esophageal squamous cell carcinoma after minimally invasive esophagectomy.	BACKGROUND: Esophageal cancer is the 7th most common cancer worldwide, while esophageal squamous cell carcinoma (ESCC) is the 4th leading cause of cancer-related deaths in China. Minimally invasive esophagectomy (MIE) is the employed as the primary treatment for ESCC. However, there is still a lack of specialized tools for evaluating postoperative outcomes in these patients. METHODS: Univariate and multivariate COX regression analyses were conducted to identify the prognostic factors. A nomogram was developed for predicting the survival probabilities at 1-, 3- and 5- year after MIE. The prediction performance of the developed nomogram was evaluated using the receiver operating characteristic (ROC) curve, concordance index (C-index), calibration curve, decision curve analysis (DCA) curve and risk stratification. RESULTS: A total of 709 patients were enrolled in the study. Age, vascular invasion, pT stage and pN stage were independent predictors of the prognosis and were used to develop a nomogram model. The areas under the curve (AUC) values predicting overall survival (OS) at 1, 3 and 5 years were 0.814, 0.761 and 0.794 in the training cohort and 0.703, 0.751 and 0.780 in the validation cohort. Furthermore, the calibration plot revealed good agreement between the predicted results and actual observations. The DCA curve confirmed that the nomogram achieved higher clinical value compared to other indicators. Further, we stratified the entire patient population into low-risk group, medium risk group and high-risk group. A significant difference in survival was observed between the three groups (P < 0.001) CONCLUSIONS: A novel nomogram for predicting ESCC patient's survival outcomes after MIE. The accuracy of the proposed nomogram exceeded that of the Union for Union for International Cancer Control(UICC)/American Joint Committee on Cancer(AJCC) 8th staging systems.	esophagus