News Finding: "Our research provides the first direct evidence that exposure to BPA during development, at the levels we see in our day-to-day lives, increases the risk for prostate cancer in human prostate tissue," Prins said.
Paper Finding: Examples of HG-PIN and prostate adenocarcinoma as well as benign lesions of hyperplasia and SQM are shown in Fig 5 with PSA immunostaining to confirm their human origin and lack of basal cell staining to confirm carcinoma.
News Context: This is a major concern as the chemical imitated the hormone estrogen. "Our research provides the first direct evidence that exposure to BPA during development, at the levels we see in our day-to-day lives, increases the risk for prostate cancer in human prostate tissue," Prins said. "The findings of adverse effects of BPA in human tissue are highly relevant and should encourage agencies like the Food & Drug Administration to re-evaluate their policies in the near future."
Paper Context: As previously observed (28), progressive malignancy incidence was noted over time with highest HG-PIN and cancer incidence present at 4 months. Examples of HG-PIN and prostate adenocarcinoma as well as benign lesions of hyperplasia and SQM are shown in Fig 5 with PSA immunostaining to confirm their human origin and lack of basal cell staining to confirm carcinoma. As shown in Table 1 , prostate grafts from animals treated with vehicle during tissue development plus T+E exposure at maturity had an overall incidence of 26% normal grafts, 74% benign lesions and 13% malignant lesions (Note: malignant lesions always co-appeared in grafts containing 16 benign lesions).