News Finding: "We believe that BPA actually reprograms the stem cells to be more sensitive to estrogen throughout life, leading to a life-long increased susceptibility to diseases including cancer," Prins said.
Paper Finding: Together, these data contribute to the increasing body of evidence for a link between fetal exposures to EDCs and cancer .
News Context: "The findings of adverse effects of BPA in human tissue are highly relevant and should encourage agencies like the Food & Drug Administration to re-evaluate their policies in the near future." The amount of BPA given to the mice was equal to the levels an average person ingests. "We believe that BPA actually reprograms the stem cells to be more sensitive to estrogen throughout life, leading to a life-long increased susceptibility to diseases including cancer," Prins said.
Paper Context: The present findings provide the first evidence that exposure of the developing human prostate epithelium to BPA at relevant human exposure levels markedly increases the incidence of prostate carcinogenesis in the mature epithelium exposed to elevated estradiol. Together, these data contribute to the increasing body of evidence for a link between fetal exposures to EDCs and cancer . In vivo BPA exposure during the time of stemprogenitor cell lineage commitment, differentiation and formation of glandular epithelium significantly boosted the rate of T+E driven carcinogenesis from 13% in vehicle exposed hosts to 33-36% malignancy.