News Finding: If these results are replicated, they imply that prioritizing policies and interventions to children who experienced adversity during those years may help reduce the long-term risk for problems like depression."
Paper Finding: These results suggest that the SLCMA allowed us to more effectively identify methylation differences among children with and without a history of exposure to adversity.
News Context: "These findings suggest that the first three years of life may be an especially important period for shaping biological processes that ultimately give rise to mental health conditions. If these results are replicated, they imply that prioritizing policies and interventions to children who experienced adversity during those years may help reduce the long-term risk for problems like depression." This is seen in both humans and animals.
Paper Context: Similarly, the top CpG site in the SLCMA (cg19157140), which suggested a sensitive period at age 1.75 associated with the effects of neighborhood disadvantage, was nonsignificant in the corresponding EWAS ( =0.001; p=0.0002; Figure 5 ). These results suggest that the SLCMA allowed us to more effectively identify methylation differences among children with and without a history of exposure to adversity. There was no evidence in support of compound theoretical models, whereby more than one theoretical model explained the most outcome variability.