News Finding: "Our data clearly suggests that obesity and the Na/K-ATPase oxidant amplification loop plays a role in neurodegeneration," said first author Rebecca Pratt, a Ph.D. candidate in the department of biomedical research at Marshall University.
Paper Finding: Our results also demonstrated a significant increase in the visceral and subcutaneous fat, liver weight, and heart weight in the mice fed a WD, which was markedly reduced with lenti-adiponectin-GFP-NaKtide treatment ( Table 1) .
News Context: The researchers were able to successfully demonstrate through decreased adiposity and an improved metabolic profile the therapeutic potential of targeting NaKtide to the adipocytes. "Our data clearly suggests that obesity and the Na/K-ATPase oxidant amplification loop plays a role in neurodegeneration," said first author Rebecca Pratt, a Ph.D. candidate in the department of biomedical research at Marshall University. "Even targeting NaKtide to adipocytes alone still showed a whole-body effect, which highlights the much larger role that adipocytes play in obesity and whole body homeostasis."
Paper Context: The increase in the body weight was significantly attenuated by the transduction of lenti-adiponectin-GFP-NaKtide ( Fig. Our results also demonstrated a significant increase in the visceral and subcutaneous fat, liver weight, and heart weight in the mice fed a WD, which was markedly reduced with lenti-adiponectin-GFP-NaKtide treatment ( Table 1) . Food intake and energy intake did not differ amongst the different experimental groups (Fig.