News Finding: The researchers were able to successfully demonstrate through decreased adiposity and an improved metabolic profile the therapeutic potential of targeting NaKtide to the adipocytes.
Paper Finding: Our results showed increases in plasma leptin concentrations in mice fed a WD.
News Context: The basis of the research examined more closely the role of the adipocyte in obesity, including how it impacts oxidative stress, inflammation, neurodegeneration and NASH. The researchers were able to successfully demonstrate through decreased adiposity and an improved metabolic profile the therapeutic potential of targeting NaKtide to the adipocytes. "Our data clearly suggests that obesity and the Na/K-ATPase oxidant amplification loop plays a role in neurodegeneration," said first author Rebecca Pratt, a Ph.D. candidate in the department of biomedical research at Marshall University.
Paper Context: Treatment with the lenti-adiponectin-GFP-NaKtide ameliorated the increases in the plasma concentrations of these inflammatory cytokines. Our results showed increases in plasma leptin concentrations in mice fed a WD. This was attenuated by treatment with lenti-adiponectin-GFP-NaKtide ( Fig.