News Finding: But this process spirals out of control in lung cancer cells, which scrap too many TIAM1 ties**.
Paper Finding: These findings reveal a molecular mechanism by which MET/HGF signaling, whose hyperactivation is associated with invasive growth of many neoplasms, stimulates epithelial cell motility and invasion.
News Context: But this process spirals out of control in lung cancer cells, which scrap too many TIAM1 ties**. Targeting this recycling process could stop lung cancer from spreading by keeping the cells stuck firmly together. Targeting this flaw could help stop lung cancer from spreading."
Paper Context: Failure to degrade TIAM1 or depletion of HUWE1 in cells results in delayed adhesion disassembly and prevents the HGF-induced stimulation of migration and invasion. These findings reveal a molecular mechanism by which MET/HGF signaling, whose hyperactivation is associated with invasive growth of many neoplasms, stimulates epithelial cell motility and invasion. Our findings here suggest that effects of HUWE1 on cell-cell adhesion and invasion via regulating TIAM1 degradation would promote epithelial tumor progression.