News Finding: IRE1 regulates the maturation of the XBP1 mRNA to produce the functional XBP1 transcription factor, which in turn bolsters the expression of target genes encoding for chaperone proteins that resolve the accumulation of misfolded proteins.
Paper Finding: However, S729A mutation completely blocks IRE1's ability to further up-regulate XBP1s to respond to any of these ER stress conditions (Fig.
News Context: This process is especially important for B cells to respond to severe stress conditions and their ability to produce antibodies. IRE1 regulates the maturation of the XBP1 mRNA to produce the functional XBP1 transcription factor, which in turn bolsters the expression of target genes encoding for chaperone proteins that resolve the accumulation of misfolded proteins. IRE1 function is especially critical in B cells since the ER plays a central role in the biogenesis of antibodies.
Paper Context: Although Tg induces phosphorylation of IRE1 only at S729 in LPS-stimulated B cells, SubAB and DTT can induce phosphorylation at S729 and other sites in these cells (Fig. However, S729A mutation completely blocks IRE1's ability to further up-regulate XBP1s to respond to any of these ER stress conditions (Fig. 6) .