News Finding: "Our research provides the first direct evidence that exposure to BPA during development, at the levels we see in our day-to-day lives, increases the risk for prostate cancer in human prostate tissue," Prins said.
Paper Finding: Although genomic actions of BPA through EREs could not be confirmed in the present study, this activity has not been excluded as it remains possible that BPA may activate genomic ER signaling on natural promoters or over a different time frame than examined herein.
News Context: The new findings show that human prostate tissue is also susceptible. "Our research provides the first direct evidence that exposure to BPA during development, at the levels we see in our day-to-day lives, increases the risk for prostate cancer in human prostate tissue," Prins said. "The findings of adverse effects of BPA in human tissue are highly relevant and should encourage agencies like the Food & Drug Administration to re-evaluate their policies in the near future."
Paper Context: BPA at doses up to 1 M did not elicit an ERE-based responses with the ERE-tk reporter (Fig 3C) . Although genomic actions of BPA through EREs could not be confirmed in the present study, this activity has not been excluded as it remains possible that BPA may activate genomic ER signaling on natural promoters or over a different time frame than examined herein. Taken together, these findings identify that both rapid membrane-initiated estrogen action and genomic ER signaling pathways are operative in human prostate progenitor cells.