News Finding: "In all cohorts, accumulation of pre-adult environmental hits was highly significantly associated with lifetime conviction for violent acts or high psychopathy and aggression-hostility scores as proxies of violent aggression and rule-breaking.
Paper Finding: Together, we provide sound evidence of a disease-independent unfortunate relationship between well-defined pre-adult environmental hits and violent aggression, calling for more efficient prevention.
News Context: "Our data support the concept of a disease-independent development of violent aggression in people exposed to multiple pre-adult environmental risk factors," says Ehrenreich. "In all cohorts, accumulation of pre-adult environmental hits was highly significantly associated with lifetime conviction for violent acts or high psychopathy and aggression-hostility scores as proxies of violent aggression and rule-breaking. Strikingly, we note that the composition of risk factors is interchangeable."
Paper Context: Conversely, determination in peripheral blood mononuclear cells of histone-deacetylase1 mRNA as 'umbrella mediator' of epigenetic processes revealed an increase in the high-risk group, suggesting lasting epigenetic alterations. Together, we provide sound evidence of a disease-independent unfortunate relationship between well-defined pre-adult environmental hits and violent aggression, calling for more efficient prevention. Moreover, these environmental risk factors seem to contribute to abnormal behavior and to severity and onset of mental illness [1] , even though different risk factors may have different impact, dependent on the particular neuropsychiatric disease in focus.