News Finding: "This is consistent with the migratory capacity of cells, adjacent to a nascent wound, being determined by the actin dynamical state at the circadian phase when the wound is incurred," the authors explain.
Paper Finding: This is consistent with the migratory capacity of cells, adjacent to a nascent wound, being determined by the actin dynamical state at the circadian phase when the wound is incurred.
News Context: When the cultures were scratched at different times, the wounds sustained in simulated 'night' conditions healed more slowly than those during the day, due to differing speeds of fibroblast response. "This is consistent with the migratory capacity of cells, adjacent to a nascent wound, being determined by the actin dynamical state at the circadian phase when the wound is incurred," the authors explain. Experiments with live mice showed the same phenomenon, with the animals healing quicker if a cut was sustained during their waking hours than if it were imposed when they would ordinarily have been asleep.
Paper Context: The timedependent difference in F-actin polarization was sustained for at least the first 9 hours of healing. This is consistent with the migratory capacity of cells, adjacent to a nascent wound, being determined by the actin dynamical state at the circadian phase when the wound is incurred. Accordingly, continuous recording of cellular impedance in PER2::LUC cultures revealed a CRY-dependent circadian oscillation, with greatest adhesion in phase with PER2 expression (Fig.