News Finding: Alpha-ketoglutarate thus appears to be responsible for part, but not all, of interleukin 2's impact on T cell gene programming.
Paper Finding: (C and D) Circos plots for genomic regions surrounding Hlx (Chr1:184,000,000-187,200,000) and Cxcr4 (Chr1:128,800,000-131,040,000), indicating the probability for genomic interactions from the in situ Hi-C analysis.
News Context: These different concentrations of interleukin 2 signaling drive the cells to turn on different gene programs and develop gene programs similar to those from either effector or memory T cells. They found that adding permeable alpha-ketoglutarate to the low interleukin 2 condition induced about a third of the gene program induced by high interleukin 2 relative to low interleukin 2 in T cells, while it inhibited about 10 percent of the genes that were more highly expressed in low interleukin 2 relative to high interleukin 2 conditions. Alpha-ketoglutarate thus appears to be responsible for part, but not all, of interleukin 2's impact on T cell gene programming.
Paper Context: However, the boundary changed or the strength of interaction bias was increased in the high IL-2 Figure 4C . (C and D) Circos plots for genomic regions surrounding Hlx (Chr1:184,000,000-187,200,000) and Cxcr4 (Chr1:128,800,000-131,040,000), indicating the probability for genomic interactions from the in situ Hi-C analysis. The minimum probability of interaction shown is a p value of % 0.0001, with the increased weight of a line indicating a higher significance for the interaction (lower p value).