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Paper Finding: In contrast to the present finding that ERαAF-1 0 mammary epithelia fail to develop alveoli, some of the ERαNeoKO epithelial grafts grew during pregnancy and developed alveoli .
News Context: "This begs the question whether these ER-pseudo-negative breast cells will ultimately turn into estrogen receptor-positive or -negative breast cancers," says Cathrin Brisken. Note: material may have been edited for length and content. For further information, please contact the cited source.
Paper Context: In addition to changes in the levels of the ligands the concomitant loss of PgR expression, which opposes many ERα actions may have a role to play. In contrast to the present finding that ERαAF-1 0 mammary epithelia fail to develop alveoli, some of the ERαNeoKO epithelial grafts grew during pregnancy and developed alveoli . It is conceivable that complete loss of ERα function in some MECs accounts for this; the activity of the resulting E1 ERα variant protein in the ERαNeoKO mice is animal and celltype dependent .