News Finding: Breeders can now use diagnostic tests for the APAF1 mutation to avoid mating two carriers while still retaining the beneficial genetic contributions derived from Chief, which are estimated to be about $30 billion in increased milk production.
Paper Finding: For example, the milk produced as a result of a successful pregnancy and the number of complete gestations in a cow's lifetime are essential to maintaining the profitability of a modern dairy operation.
News Context: A single midterm abortion could cost a dairy about $800. Breeders can now use diagnostic tests for the APAF1 mutation to avoid mating two carriers while still retaining the beneficial genetic contributions derived from Chief, which are estimated to be about $30 billion in increased milk production. Just as rapid, low-cost genotyping revolutionized dairy cattle breeding, so too will whole-genome sequencing be used to increase the accuracy of sire and dam selection," Lewin says.
Paper Context: We thus propose that the APAF1 p.Q579X nonsense mutation is the functional equivalent of the Apaf1 knockout. For example, the milk produced as a result of a successful pregnancy and the number of complete gestations in a cow's lifetime are essential to maintaining the profitability of a modern dairy operation. If reproductive performance decreases, financial losses accrue because of reduced milk production of the herd and the need for replacement animals to maintain herd size.