News Finding: These principles are illustrated in the review and supported with recent examples of discovery projects against a range of potential antibiotic targets.
Paper Finding: In general, no particular technique can be regarded as a "bestin-class" solution, but it is useful to be aware of and consider all available options.
News Context: These principles are illustrated in the review and supported with recent examples of discovery projects against a range of potential antibiotic targets. Because the fragments are small, they are more likely to fit into a binding site and each fragment represents a huge number of potential compounds.
Paper Context: It also has high requirements for the solubility of the ligand (if titrated). In general, no particular technique can be regarded as a "bestin-class" solution, but it is useful to be aware of and consider all available options. Each of the techniques also has particular requirements in terms of the solubility of the protein and the solubility of the ligands screened and can robustly detect different dynamic ranges of binding affinity.