News Finding: But if it does, future vaccines could try to mimic the effect of bacteria to prompt a bigger immune response.
Paper Finding: We found fewer TIV-specific IgG + ASCs and lower serum IgG in antibiotic-treated mice at day 5 after boost injection (Figures 3G and 3H) .
News Context: He cautions that the group would need to expose the mice to flu after vaccination to confirm that bacterial signals influence the vaccine-induced resistance to the virus. But if it does, future vaccines could try to mimic the effect of bacteria to prompt a bigger immune response. The results also raise questions about the role of antibiotics in vaccine response, says Paul Thomas, an immunologist at St. Jude Children's Research Hospital in Memphis, Tennessee.
Paper Context: These results suggest that TLR5 signaling plays an important role in differentiation or function of memory B cells following vaccination with TIV. We found fewer TIV-specific IgG + ASCs and lower serum IgG in antibiotic-treated mice at day 5 after boost injection (Figures 3G and 3H) . A pairwise analysis between the corresponding serum ELISA and B cell ELISPOT samples revealed a positive correlation between the frequency of ASCs and the magnitude of TIV-specific IgG antibodies in the serum (Figure 3I ).