News Finding: These different concentrations of interleukin 2 signaling drive the cells to turn on different gene programs and develop gene programs similar to those from either effector or memory T cells.
Paper Finding: This creates a scenario where metabolically regulated changes in CTCF association and genome interactions might be interpreted in a cell-type-or context-dependent manner depending upon the enhancer landscape present.
News Context: Thus, control sites used during embryo growth were also likely being used to control T cell changes after an immune challenge. These different concentrations of interleukin 2 signaling drive the cells to turn on different gene programs and develop gene programs similar to those from either effector or memory T cells. They found that adding permeable alpha-ketoglutarate to the low interleukin 2 condition induced about a third of the gene program induced by high interleukin 2 relative to low interleukin 2 in T cells, while it inhibited about 10 percent of the genes that were more highly expressed in low interleukin 2 relative to high interleukin 2 conditions.
Paper Context: In order for changes in CTCF binding events that influence genome organization to exert a functional outcome on gene expression, an active enhancer landscape would need to be present in that region. This creates a scenario where metabolically regulated changes in CTCF association and genome interactions might be interpreted in a cell-type-or context-dependent manner depending upon the enhancer landscape present. The IL-2-and aKG-sensitive effector genes in Th1 cells tended to contain regions of H3K27Ac in proximity to the genes that were actively expressed ( Figures 7B and S7B) .