News Finding: KCNA2 can cause epileptic encephalopathies after gain-of-function or loss-of-function mutations 
Paper Finding: Comparing the allele frequency of the 6 KCNA2 nonsynonymous variants in our validation cohorts (6/(354 × 2); excluding the first mutation encoding p.Pro405Leu detected in the discovery cohort of 33 patients) with those of missense and nonsense variants reported in the largest available control database (ExAC; 144/122,828) showed a significant enrichment of KCNA2 variants in our patient cohorts using Fisher's exact test (P = 2.6 × 10 −4 ).
News Context: KCNA2 can cause epileptic encephalopathies after gain-of-function or loss-of-function mutations 
Paper Context: Similarly, patient 7 carrying the de novo mutation c.890G>A (encoding p.Arg297Gln) presented with a more severe phenotype consisting of moderate intellectual disability, moderate to severe ataxia and pharmacoresistant seizures. Comparing the allele frequency of the 6 KCNA2 nonsynonymous variants in our validation cohorts (6/(354 × 2); excluding the first mutation encoding p.Pro405Leu detected in the discovery cohort of 33 patients) with those of missense and nonsense variants reported in the largest available control database (ExAC; 144/122,828) showed a significant enrichment of KCNA2 variants in our patient cohorts using Fisher's exact test (P = 2.6 × 10 −4 ). Further statistical evidence is provided in the Supplementary Note.