News Finding: If you're drinking from a water bottle or eating from a plastic container, chances are you're consuming it right now.
Paper Finding: This carcinogenic rate further increased to 45% when developmental BPA exposure was extended to in vitro stem cell cultures, implicating the stem-progenitor cells as the direct BPA targets, a hypothesis supported by the in vitro studies discussed above.
News Context: "Our research provides the first direct evidence that exposure to BPA during development, at the levels we see in our day-to-day lives, increases the risk for prostate cancer in human prostate tissue," Gail Prins, a professor of physiology and lead author of the paper, said in a press release. If you're drinking from a water bottle or eating from a plastic container, chances are you're consuming it right now. According to the study authors, avoiding the chemical altogether is a next-to impossible feat.
Paper Context: In vivo BPA exposure during the time of stemprogenitor cell lineage commitment, differentiation and formation of glandular epithelium significantly boosted the rate of T+E driven carcinogenesis from 13% in vehicle exposed hosts to 33-36% malignancy. This carcinogenic rate further increased to 45% when developmental BPA exposure was extended to in vitro stem cell cultures, implicating the stem-progenitor cells as the direct BPA targets, a hypothesis supported by the in vitro studies discussed above. That these malignant lesions arose from normal prostate epithelium in the relatively short time frame of 2-4 months, as compared to decades in humans, is particularly noteworthy and highlights the potent nature of this EDC on augmenting carcinogenic susceptibility.