News Finding: Researchers now hope these new insights will be able to lead to new treatment opportunities for patients with these conditions.
Paper Finding: The absence of altered collagen IV mRNA levels provides evidence that PBA is acting through its chemical chaperone activity.
News Context: Research will also be developed to explore how, and if, a similar treatment strategy could be applied to humans with brain bleeding caused by these genetic alterations. Researchers now hope these new insights will be able to lead to new treatment opportunities for patients with these conditions. This work has identified a potential treatment strategy in mice and is the first step in translating this to patients.
Paper Context: Besides a chemical chaperone PBA can also act as a histone deacetylase inhibitor . The absence of altered collagen IV mRNA levels provides evidence that PBA is acting through its chemical chaperone activity. In addition, although PBA has been shown to be able to reduce blood pressure in hypertension (44), it did not affect blood pressure in our model, indicating its effects on ICH is independent of blood pressure.