News Finding: "We believe that BPA actually reprograms the stem cells to be more sensitive to estrogen throughout life, leading to a life-long increased susceptibility to diseases including cancer," Prins said.
Paper Finding: Similar to the prostasphere assay, 1-10 nM E 2, but not 100 nM, significantly increased the percentage of stem-like cells in primary cultures indicating a stimulation of their self-renewal capacity (Fig 1C) .
News Context: "The findings of adverse effects of BPA in human tissue are highly relevant and should encourage agencies like the Food & Drug Administration to re-evaluate their policies in the near future." The amount of BPA given to the mice was equal to the levels an average person ingests. "We believe that BPA actually reprograms the stem cells to be more sensitive to estrogen throughout life, leading to a life-long increased susceptibility to diseases including cancer," Prins said.
Paper Context: As shown in Fig 1A, (Fig 1B) . Similar to the prostasphere assay, 1-10 nM E 2, but not 100 nM, significantly increased the percentage of stem-like cells in primary cultures indicating a stimulation of their self-renewal capacity (Fig 1C) . Collectively, these findings show that estrogen stimulates human prostate epithelial stem cell self-renewal and progenitor cell amplification (prostasphere size), with greatest effects observed at lower E 2 doses.