News Finding: Hormones keep on surprising us. Wonderful collaborative effort from the lab shows that estrogen receptor signaling in the breast epithelium is much more complex than we previously thought. Time to revisit some of our models!    #BriskenLab #EPFL 
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Paper Finding: In contrast to the present finding that ERαAF-1 0 mammary epithelia fail to develop alveoli, some of the ERαNeoKO epithelial grafts grew during pregnancy and developed alveoli .
News Context: Hormones keep on surprising us. Wonderful collaborative effort from the lab shows that estrogen receptor signaling in the breast epithelium is much more complex than we previously thought. Time to revisit some of our models!    #BriskenLab #EPFL 
  @username 
Paper Context: In addition to changes in the levels of the ligands the concomitant loss of PgR expression, which opposes many ERα actions may have a role to play. In contrast to the present finding that ERαAF-1 0 mammary epithelia fail to develop alveoli, some of the ERαNeoKO epithelial grafts grew during pregnancy and developed alveoli . It is conceivable that complete loss of ERα function in some MECs accounts for this; the activity of the resulting E1 ERα variant protein in the ERαNeoKO mice is animal and celltype dependent .