News Finding: "The amount of BPA we fed the mice was equivalent to levels ingested by the average person," Prins said.
Paper Finding: Similar to estradiol-17 (E2), BPA increased stem-progenitor cell self-renewal and expression of stem-related genes in a dose-dependent manner.
News Context: "The findings of adverse effects of BPA in human tissue are highly relevant and should encourage agencies like the Food & Drug Administration to re-evaluate their policies in the near future." "The amount of BPA we fed the mice was equivalent to levels ingested by the average person," Prins said. "We didn't feed them exorbitantly high doses."
Paper Context: Similar to estradiol-17 (E2), BPA increased stem-progenitor cell self-renewal and expression of stem-related genes in a dose-dependent manner. Further, 10 nM BPA and E2 possessed equimolar membrane-initiated signaling with robust induction of p-Akt and p-Erk at 15 min. The incidence of prostate intraepithelial neoplasia (HG-PIN) and adenocarcinoma markedly increased from 13% in oil-fed controls to 33-36% in grafts exposed in vivo to BPA (P<0.05).