News Finding: "We believe that BPA actually reprograms the stem cells to be more sensitive to estrogen throughout life, leading to a life-long increased susceptibility to diseases including cancer," Prins said.
Paper Finding: Similar to estradiol-17 (E 2 ), BPA increased stem-progenitor cell self-renewal and expression of stem-related genes in a dose-dependent manner.
News Context: "The findings of adverse effects of BPA in human tissue are highly relevant and should encourage agencies like the Food & Drug Administration to re-evaluate their policies in the near future." The amount of BPA given to the mice was equal to the levels an average person ingests. "We believe that BPA actually reprograms the stem cells to be more sensitive to estrogen throughout life, leading to a life-long increased susceptibility to diseases including cancer," Prins said.
Paper Context: Together, the present findings demonstrate that human prostate stem-progenitor cells are direct BPA targets and that developmental exposure to BPA at low-doses increases hormone dependent cancer risk in the human prostate epithelium. Similar to estradiol-17 (E 2 ), BPA increased stem-progenitor cell self-renewal and expression of stem-related genes in a dose-dependent manner. Further, 10 nM BPA and E 2 possessed equimolar membrane-initiated signaling with robust induction of p-Akt and p-Erk at 15 min.