News Finding: The results from this study at Marshall University demonstrate that the Na/K-ATPase oxidant amplification loop in adipocytes, or cells specialized for fat storage, when impaired, could cause adipocyte dysfunction, worsening obesity and potentially increasing the severity of related diseases.
Paper Finding: In this study, our results showed that targeting of NaKtide specifically to adipocytes was still able to reverse WD-induced changes in metabolic profile, oxidative stress, and inflammation.
News Context: "I am very excited about the work in the current Scientific Reports article and the clinical relevance it presents for the role of adipocytes in obesity and other disease states," said Komal Sodhi, M.D., senior author, and associate professor of surgery and biomedical sciences at the Joan C. Edwards School of Medicine. The results from this study at Marshall University demonstrate that the Na/K-ATPase oxidant amplification loop in adipocytes, or cells specialized for fat storage, when impaired, could cause adipocyte dysfunction, worsening obesity and potentially increasing the severity of related diseases. The basis of the research examined more closely the role of the adipocyte in obesity, including how it impacts oxidative stress, inflammation, neurodegeneration and NASH.
Paper Context: S6 B-F. N = 12-14/group; *p < 0.05 vs. CTR, **p < 0.01 vs. CTR, # p < 0.05 vs. WD, ## p < 0.01 vs. WD. In this study, our results showed that targeting of NaKtide specifically to adipocytes was still able to reverse WD-induced changes in metabolic profile, oxidative stress, and inflammation. This highlights the importance of the Na/K-ATPase oxidant amplification loop within the adipocyte as well as the importance of adipocyte biology itself.