News Finding: The mice could no longer recognize a familiar object.
Paper Finding: Among 84 genes analyzed, AdFNDC5 rescued Aβ O-induced changes in expression of six genes, whose expression levels were independently validated by qPCR.
News Context: Next, the researchers showed that irisin is both necessary and sufficient for protecting memories from degradation. The mice could no longer recognize a familiar object. The irisin blocked the memory loss that was caused by the amyloid b aggregates.
Paper Context: Infection with AdFNDC5 led to increases in FNDC5/irisin mRNA expression and protein levels in the cortex (Fig. Among 84 genes analyzed, AdFNDC5 rescued Aβ O-induced changes in expression of six genes, whose expression levels were independently validated by qPCR. 7 ), indicating possible protective actions of FNDC5/irisin against aberrant expression of synapse-related genes.