News Finding: We hope that it will be possible in the future to target microglia subsets in harmful state."
Paper Finding: Overall, our results suggest that unique microglia subpopulations, characterized by distinct signatures, emerge under defined disease conditions.
News Context: "In MS patients, we managed to characterize microglia in a state that is specific for multiple sclerosis. We hope that it will be possible in the future to target microglia subsets in harmful state." "It is extremely exciting to see how flexible the microglia can be," says Prof. Prinz.
Paper Context: 3d (Fig. Overall, our results suggest that unique microglia subpopulations, characterized by distinct signatures, emerge under defined disease conditions. Unbiased hierarchical clustering revealed four major clusters, hereafter referred to as healthy human clusters 1 to 4 (HHu-C1 to HHu-C4) (Extended Data Fig.