News Finding: Indeed, using transcript analysis, the researchers found that, like cancer cells, senescent cells have increased expression of "pro-survival networks" that help them resist apoptosis or programmed cell death.
Paper Finding: Similar to cancer cells, here we demonstrated that silencing EFNB ligands induces apoptosis selectively in senescent as compared to nonsenescent cells.
News Context: "It may eventually become feasible to delay, prevent, alleviate or even reverse multiple chronic diseases and disabilities as a group, instead of just one at a time." Indeed, using transcript analysis, the researchers found that, like cancer cells, senescent cells have increased expression of "pro-survival networks" that help them resist apoptosis or programmed cell death. This finding provided key criteria to search for potential drug candidates.
Paper Context: EFNB ligands can participate in dependence networks that constrain both the cells they are located on and adjacent cells from undergoing apoptosis . Similar to cancer cells, here we demonstrated that silencing EFNB ligands induces apoptosis selectively in senescent as compared to nonsenescent cells. Silencing EFNB3 expression down-regulates AKT in cancer cells .