News Finding: Then the team identified 27 unique bacterial features unique to the gut microbiomes, and thus stool, of people with NAFLD-cirrhosis.
Paper Finding: This study leverages from a unique and well-characterized cohort including participants with NAFLD-cirrhosis which allows studying the specific gutmicrobiome signature of this extreme and well-defined clinical phenotype.
News Context: In addition, they observed that people with extreme forms of NAFLD had less diverse and less stable gut microbiomes. Then the team identified 27 unique bacterial features unique to the gut microbiomes, and thus stool, of people with NAFLD-cirrhosis. The researchers were able to use this noninvasive stool test to pick out the people with known NAFLD-cirrhosis with 92 percent accuracy.
Paper Context: Hence, this conveniently assessed microbial biomarker could present an adjunct tool to current invasive approaches to determine stage of liver disease. This study leverages from a unique and well-characterized cohort including participants with NAFLD-cirrhosis which allows studying the specific gutmicrobiome signature of this extreme and well-defined clinical phenotype. The fundamental difference between the previous study and the present study is the clinical context of use of the gut-microbiome signature.