News Finding: "Kv1.2 channels efficiently repolarize a nerve cell following an action potential.
Paper Finding: The panel used to screen the pilot cohort of 33 patients (including the index patient) comprised 485 known and putative epilepsy-related genes (Supplementary Table 1) .
News Context: In six children, the researchers found so far unknown spontaneous mutations in the KCNA2gene that have not been present in the genome of their parents. "Kv1.2 channels efficiently repolarize a nerve cell following an action potential. It is hence not so surprising that mutations that render this channel dysfunctional can lead to hyperexcitation of the brain.
Paper Context: Clinical genetic studies and correlation with functional investigations from additional patients with further mutations are needed to confirm this genotypephenotype relationship. The panel used to screen the pilot cohort of 33 patients (including the index patient) comprised 485 known and putative epilepsy-related genes (Supplementary Table 1) . The comparison of normalized peak areas for the test individual and the average of seven control individuals yields target amplicon doses indicating the copy number of the target amplicon (using the in house-developed MAQ software).