News Finding: In tissue samples taken from a control group, the figure was 12 percent.
Paper Finding: The incidence of prostate intraepithelial neoplasia (HG-PIN) and adenocarcinoma markedly increased from 13% in oil-fed controls to 33-36% in grafts exposed in vivo to BPA (P<0.05).
News Context: The team found that about one-third of tissue samples taken from mice fed BPA showed signs of prostate cancer or precancerous lesion. In tissue samples taken from a control group, the figure was 12 percent. "The findings of adverse effects of BPA in human tissue are highly relevant and should encourage agencies like the Food & Drug Administration to re-evaluate their policies in the near future," Prins said of the results.
Paper Context: Together, the present findings demonstrate that human prostate stem-progenitor cells are direct BPA targets and that developmental exposure to BPA at low-doses increases hormone dependent cancer risk in the human prostate epithelium. The incidence of prostate intraepithelial neoplasia (HG-PIN) and adenocarcinoma markedly increased from 13% in oil-fed controls to 33-36% in grafts exposed in vivo to BPA (P<0.05). Continuous developmental BPA exposure through in vitro (200 nM) plus in vivo (250 µg/kg BW) treatments increased HG-PIN/cancer incidence to 45% (P< 0.01).