News Finding: When the program ended, the participants experienced a reduction of risk factors related to several illnesses including cancer, heart disease, diabetes and aging.
Paper Finding: These concerns point to the need for dietary interventions that induce PF-like effects while minimizing the risk of adverse effects and the burden of complete food restriction.
News Context: It provided them with around 34 percent to 54 percent of their normal calorie intake made up of 11 percent to 14 percent of proteins, 42 percent to 43 percent of carbohydrates and 44 percent to 46 percent of fat. When the program ended, the participants experienced a reduction of risk factors related to several illnesses including cancer, heart disease, diabetes and aging. "This is arguably the first non-chronic pre-clinically and clinically tested anti-aging and healthspan-promoting intervention shown to work and to be very feasible as a doctor or dietitian-supervised intervention," Longo said.
Paper Context: In humans, IF and less-severe regimens (e.g., consumption of approximately 500 kcal/day for 2 days a week) have beneficial effects on insulin, glucose, C-reactive protein, and blood pressure . These concerns point to the need for dietary interventions that induce PF-like effects while minimizing the risk of adverse effects and the burden of complete food restriction. PF cycles extended both medium and maximum chronological lifespan (Figures 1A and 1B) and increased the number of yeast cells that survive hydrogen peroxide treatment by more than 100-fold ( Figure 1C) .