News Finding: "I am very excited about the work in the current Scientific Reports article and the clinical relevance it presents for the role of adipocytes in obesity and other disease states," said Komal Sodhi, M.D., senior author, and associate professor of surgery and biomedical sciences at the Joan C. Edwards School of Medicine.
Paper Finding: This was prevented by lenti-adiponectin-GFP-NaKtide treatment ( Fig.
News Context: "I am very excited about the work in the current Scientific Reports article and the clinical relevance it presents for the role of adipocytes in obesity and other disease states," said Komal Sodhi, M.D., senior author, and associate professor of surgery and biomedical sciences at the Joan C. Edwards School of Medicine. The results from this study at Marshall University demonstrate that the Na/K-ATPase oxidant amplification loop in adipocytes, or cells specialized for fat storage, when impaired, could cause adipocyte dysfunction, worsening obesity and potentially increasing the severity of related diseases. The basis of the research examined more closely the role of the adipocyte in obesity, including how it impacts oxidative stress, inflammation, neurodegeneration and NASH.
Paper Context: Expression of the α1 subunit of the Na/K-ATPase was significantly down regulated in visceral fat of mice fed a WD. This was prevented by lenti-adiponectin-GFP-NaKtide treatment ( Fig. Conversely, the up-regulated expression of the α2 subunit in mice fed a WD was significantly attenuated by lenti-adiponectin-GFP-NaKtide ( Fig.