News Finding: "This strategy is super cool and it works great," he says.
Paper Finding: We observed a similarly dramatic reduction in GOA-1 protein levels in this strain ( Figure  4B , compare protein levels in lanes 3 and 4).
News Context: The advance should allow deeper insights into protein function, Chase says, "because we can only get a true understanding of what that single protein does when we isolate its function in a living organism. "This strategy is super cool and it works great," he says. "We've already used it to tease apart some of the mechanisms of dopamine signaling, but the strategy can be adapted to study the function of any protein involved in any biological process."
Paper Context: In stark contrast, when we restored NMD activity in smg-5 goa-1 animals to all cells that also expressed the tagged transgene, using an integrated untagged goa-1p::SMG-5 transgene, we found that the abundance of tagged transgene mRNA was reduced by .87% compared to goa-1p::GOA-1::let-858 mRNA levels in smg-5 goa-1 double mutants that did not express the untagged goa-1p::SMG rescue transgene ( Figure  4A , compare bars 3 and 4). We observed a similarly dramatic reduction in GOA-1 protein levels in this strain ( Figure  4B , compare protein levels in lanes 3 and 4). Indeed, expression of the untagged goa-1p::SMG-5 transgene reduced GOA-1 mRNA and protein expression to near null levels, which correlated well with null-like behaviors observed in this strain as shown in Figure 3 ( Figure 4A , compare bars 2 and 4 and protein levels in Figure 4B , lanes 2 and 4).