News Finding: "We believe that BPA actually reprograms the stem cells to be more sensitive to estrogen throughout life, leading to a life-long increased susceptibility to diseases including cancer," Prins said.
Paper Finding: As previously observed (28), progressive malignancy incidence was noted over time with highest HG-PIN and cancer incidence present at 4 months.
News Context: Prins found that a third of tissue samples taken from mice fed BPA had either pre-cancerous lesions or prostate cancer, compared to only 12 percent in a control group of mice fed oil. If the prostate stem cells were exposed to BPA before implantation and again as they produced prostate tissue in the mice, 45 percent of the tissue samples had pre-cancerous lesions or cancer. "We believe that BPA actually reprograms the stem cells to be more sensitive to estrogen throughout life, leading to a life-long increased susceptibility to diseases including cancer," Prins said.
Paper Context: Together, these results document that levels of bioactive BPA in the present study are similar to levels found in human umbilical cord blood and newborns in the general population . As previously observed (28), progressive malignancy incidence was noted over time with highest HG-PIN and cancer incidence present at 4 months. Examples of HG-PIN and prostate adenocarcinoma as well as benign lesions of hyperplasia and SQM are shown in Fig 5 with PSA immunostaining to confirm their human origin and lack of basal cell staining to confirm carcinoma.