News Finding: They found that resistance to PARP inhibitors cause some cancer cells to develop vulnerabilities to alternative cancer treatments, including radiotherapy or platinum-based chemotherapy.
Paper Finding: 4a ) 33 .
News Context: But when Shieldin levels are low, patients can develop resistance to these drugs." Mice had low levels of Shieldin originally and didn't respond to the PARP inhibitors. They found that resistance to PARP inhibitors cause some cancer cells to develop vulnerabilities to alternative cancer treatments, including radiotherapy or platinum-based chemotherapy.
Paper Context: TRF2ts inactivation at higher temperatures results in deprotected chromosome ends and causes NHEJ-mediated telomere fusions ( Fig. 4a ) 33 . Strikingly, through the use of short-hairpin RNA (shRNA) mediated mRNA silencing, we found that such chromosome fusions were diminished by FAM35A or C20orf196 depletion, like that elicited by MAD2L2 depletion ( Fig.