News Finding: Compared with unvaccinated lesions, the vaccinated lesions had evidence of lymphoid cell proliferation.
Paper Finding: Within-subject increases in tissue CD8 + T cells were significantly greater than the increases we have reported previously in unvaccinated subjects followed over the same time frame (P = 0.0300, fig.
News Context: Cervical tissue after vaccination had organized lymphoid-like structures within the surrounding connecting tissue adjacent to the lesions. Compared with unvaccinated lesions, the vaccinated lesions had evidence of lymphoid cell proliferation. The researchers also detected an immune signature within the dysplastic epithelium.
Paper Context: These infiltrates were localized in foci of residual dysplasia, not in immediately adjacent normal mucosa. Within-subject increases in tissue CD8 + T cells were significantly greater than the increases we have reported previously in unvaccinated subjects followed over the same time frame (P = 0.0300, fig. These infiltrates included increased absolute numbers of Tbet + cells, suggestive of an effector T cell response.