copenlu/druid huggingface dataset:
Claim: Moderna was already producing COVID-19 vaccines before the beginning of the pandemic (Instagram users, 2023-02-09)
Evidence (2024-10-07): After SARS-CoV-2 (the virus that causes COVID) was discovered, vaccine development moved very quickly. In February 2020 the first batch of vaccines was completed (from Moderna) and the first clinical trials began in March. [...] While scientists had been working on mRNA vaccines for decades before the COVID pandemic, the COVID shots from Pfizer/BioNTech and Moderna were the first mRNA vaccines to be approved for human use. [...] Developing vaccines for COVID was a huge challenge, but one that can mostly be judged a success. Research has estimated COVID vaccines saved 14.4 million lives across 185 countries in just their first year.
Claim: Moderna was already producing COVID-19 vaccines before the beginning of the pandemic (Instagram users, 2023-02-09)
Evidence (2024-08-22): HCoVs have been circulating in the population for decades, and no licensed CoV vaccine was available until December 2020 as a direct consequence of the COVID-19 pandemic. Before the pandemic, a few vaccine candidates against MERS-CoV, MVA-MERS-S, GLS-5300 DNA, and ChAdOx1-MERS were tested in phase I clinical trials82,83,84,85,86. Nevertheless, none were entered into phase II or III trials and approved for human use by the US FDA (United States Food and Drug Administration). [...] Since developing a vaccine that protects against all CoVs is likely difficult to achieve due to its genetic variability, as discussed above, a tiered approach likely has a higher chance of success, beginning with COVID-19 vaccines, which can protect against all VOCs, to pan-sarbecovirus vaccines, to pan-betacoronavirus vaccines, to universal or pan-coronavirus vaccines139. Both Pfizer and Moderna have developed bivalent vaccines targeting ancestral SARS-CoV-2 and Omicron. Compared to the monovalent booster, these second-generation vaccines have moderately higher or similar effectiveness in inducing neutralizing antibody responses against Omicron variants in vaccinated infection-naïve cohorts140,141,142. However, immune imprinting and the antigenic variation within Omicron limit the induction of neutralizing antibody responses against newer variants143,144,145,146,147. A recent study carried out on serum samples obtained from participants who had received one or two monovalent boosters or the mRNA bivalent booster indicated that the neutralizing antibody responses are lower against BA.1, BA.5, BA.2.75.2, BQ.1.1, and XBB as that of the ancestral strain WA1 in all three cohorts148.
Claim: Moderna was already producing COVID-19 vaccines before the beginning of the pandemic (Instagram users, 2023-02-09)
Evidence (2023-09-18): FULL CLAIM: Moderna was already producing COVID-19 vaccines before the beginning of the pandemic; its CEO, Stéphane Bancel, predicted the pandemic [...] Another iteration of that type of claim is that Stéphane Bancel, CEO of the COVID-19 mRNA vaccine company Moderna, declared that Moderna was already producing 100,000 doses of COVID-19 vaccines in 2019, prior to the pandemic. This declaration would have occurred during a panel titled "The state of the pandemic" at the World Economic Forum in Davos on 18 January 2023. However, this is a misinterpretation of Bancel’s declaration, as we explain below. [...] Never did he specify that he was talking about COVID-19 vaccine doses. In fact, Bancel was commenting on the general Moderna manufacturing capacity in 2019 for any kind of vaccines. Moderna has been producing mRNA therapeutics since 2010 and was already working on mRNA vaccine candidates for other diseases in 2019. Moderna’s report to investors for the third quarter of 2019 shows that Moderna’s pipeline had at least three mRNA vaccine candidates, for Zika, RSV, and CMV. Furthermore, nowhere in the report is mentioned the development or production of mRNA vaccines for any coronavirus.
Claim: Moderna was already producing COVID-19 vaccines before the beginning of the pandemic (Instagram users, 2023-02-09)
Evidence (2021-06-14): Alarmist articles are circulating online claiming that newly revealed "secret documents" show that the U.S. government had coronavirus vaccine candidates from Moderna in development weeks before the COVID-19 outbreak, and thus proves that the pandemic was planned. [...] Another article on a website called GreatGameIndia.com claimed: "Secret Docs Reveal Moderna Sent Coronavirus Vaccine To North Carolina University Weeks Before Pandemic." [...] GreatGameIndia.com, Secret Docs Reveal Moderna Sent Coronavirus Vaccine To North Carolina University Weeks Before Pandemic, June 20, 2021
Claim: Moderna was already producing COVID-19 vaccines before the beginning of the pandemic (Instagram users, 2023-02-09)
Evidence (2023-02-12): An article published on the website News Punch on Feb. 10 said, "Moderna CEO Stéphane Bancel has been caught admitting to his friends at the World Economic Forum that his company produced 100,000 doses of Covid-19 vaccine doses in 2019 – before the pandemic started." [...] An article and Instagram posts claim Moderna CEO Stéphane Bancel said the company produced 100,000 doses of the COVID-19 vaccine before the pandemic. [...] Health Feedback, Moderna didn’t already produce COVID-19 mRNA vaccines before the pandemic; statement by CEO of Moderna misinterpreted, Feb. 14, 2023
Claim: Moderna was already producing COVID-19 vaccines before the beginning of the pandemic (Instagram users, 2023-02-09)
Evidence (2021-07-03): What people might not understand is that extensive research was being done on mRNA technology and other mRNA vaccines for years. That decade plus of experience and the innovation of mRNA technology itself is what allowed Moderna to produce its Covid mRNA vaccine so quickly as the pandemic struck. And it could also change the future of medicine. [...] Moderna delivered the first doses of its Covid-19 vaccine to the NIH for testing on Feb. 24, 2020, and "the first Moderna shot went into a volunteer's arm in Seattle on March 16, 2020," according to Afeyan. [...] One of the reasons Moderna's mRNA Covid vaccine development moved so quickly is because scientists had been working with mRNA for years.
Claim: Moderna was already producing COVID-19 vaccines before the beginning of the pandemic (Instagram users, 2023-02-09)
Evidence (2024-07-17): - ^ "Moderna Announces Primary Efficacy Analysis in Phase 3 COVE Study for Its COVID-19 Vaccine Candidate and Filing Today with U.S. FDA for Emergency Use Authorization". Moderna, Inc. (Press release). 30 November 2020. Archived from the original on 30 November 2020. Retrieved 30 November 2020. [...] - ^ "COVID-19 Vaccine Moderna EPAR". European Medicines Agency (EMA). 4 January 2021. Archived from the original on 12 March 2021. Retrieved 20 January 2021. [...] - ^ "COVID-19 Vaccine Moderna". Union Register of medicinal products. Archived from the original on 24 January 2021. Retrieved 14 January 2021.
Claim: Moderna was already producing COVID-19 vaccines before the beginning of the pandemic (Instagram users, 2023-02-09)
Evidence (2021-01-11): Bancel said that he wanted to launch a project to use mRNA to attempt a vaccine against the new coronavirus. At that point, Moderna had more than 20 drugs in development but none had even reached the final stage of clinical trials. Nevertheless, Afeyan instantly authorized him to start work. "Don’t worry about the board," he said. "Just get moving." Lacking Pfizer’s resources, Moderna had to depend on funding from the U.S. government. Anthony Fauci, head of the National Institute of Allergy and Infectious Diseases, was supportive. "Go for it," he declared. "Whatever it costs, don’t worry about it." [...] The COVID-19 pandemic that killed more than 1.8 million people in 2020 will not be the final plague. However, thanks to the new RNA technology, our defenses against most future plagues are likely to be immensely faster and more effective. As new viruses come along, or as the current coronavirus mutates, researchers can quickly recode a vaccine’s mRNA to target the new threats. "It was a bad day for viruses," Moderna’s chair Afeyan says about the Sunday when he got the first word of his company’s clinical trial results. "There was a sudden shift in the evolutionary balance between what human technology can do and what viruses can do. We may never have a pandemic again."
Claim: Moderna was already producing COVID-19 vaccines before the beginning of the pandemic (Instagram users, 2023-02-09)
Evidence (2024-08-30): Important Information About the Correct Dosage and Administration of Moderna COVID-19 Vaccine (2023-2024 Formula) for Individuals 6 Months Through 11 Years of Age [...] The FDA announced revisions to the patient and provider fact sheets for the Moderna and Pfizer-BioNTech COVID-19 vaccines regarding the suggested increased risks of myocarditis (inflammation of the heart muscle) and pericarditis (inflammation of the tissue surrounding the heart) following vaccination; and reached a milestone of approving 1,000 original and supplemental generic drug applications to help in the treatment of patients with COVID-19 since the start of the pandemic. [...] Discussing data for Moderna’s COVID-19 Vaccine for children 6 through 17 years of age, Moderna's COVID-19 Vaccine for children 6 months through 5 years of age, and Pfizer-BioNTech's COVID-19 Vaccine for children 6 months through 4 years of age
Claim: Moderna was already producing COVID-19 vaccines before the beginning of the pandemic (Instagram users, 2023-02-09)
Evidence (2021-02-11): As of February 5, 2021, the U.S. had over 26 million cumulative reported cases of COVID-19 and about 449,020 reported deaths, according to the Centers for Disease Control and Prevention. The country also continues to experience serious economic repercussions, with the unemployment rate and number of unemployed in January 2021 at nearly twice their pre-pandemic levels in February 2020. In May 2020, OWS was launched and included a goal of producing 300 million doses of safe and effective COVID-19 vaccines with initial doses available by January 2021. Although FDA has authorized two vaccines for emergency use, OWS has not yet met its production goal. Such vaccines are crucial to mitigate the public health and economic impacts of the pandemic.
Claim: Moderna was already producing COVID-19 vaccines before the beginning of the pandemic (Instagram users, 2023-02-09)
Evidence (2024-09-26): These latest COVID-19 vaccines are produced by the drug companies Moderna, Novavax, and Pfizer-BioNTech. [...] The Pfizer and Moderna vaccines are a type known as an mRNA vaccine. (Read more about COVID-19 vaccine types.) For people ages 12 and older who are unable to get an updated mRNA vaccine, or choose not to, another type of vaccine, made by the biotech company Novavax, is available. The Novavax product is a protein subunit vaccine. Two doses are recommended three weeks apart if you haven’t been vaccinated for COVID-19 before. [...] As of September 2023, the updated COVID-19 vaccine formulations produced by Moderna and Pfizer are fully approved for use as a single dose for people ages 12 and older, and have emergency use authorization for use in children 6 months through 11 years. (Note that the total number of shots differs for infants, very young children and some people with highly weakened immune systems.) Novavax’s COVID-19 vaccine is available under emergency authorization as a two-dose initial series or a single booster six months later for people 12 and older.
Claim: Moderna was already producing COVID-19 vaccines before the beginning of the pandemic (Instagram users, 2023-02-09)
Evidence (2020-12-10): The COVID-19 vaccines coming soon to the United States and already approved in the U.K. and Canada are the fastest vaccines ever created. [...] The COVID-19 vaccines from Pfizer, Moderna and AstraZeneca make use of two of these new strategies, or "platforms," which makes them unlike any other commonly used vaccines. Most familiar vaccines — against flu, measles or tetanus, for example — rely on inactivated viruses (flu and tetanus) or weakened virus strains (measles, mumps), says Dr. Yang. Some vaccines, such as the one for hepatitis B, employ artificial proteins created in a lab. Each of these strategies requires development specific to the exact virus or bacterium. [...] The Pfizer and Moderna vaccines are based on the messenger RNA, or mRNA, platform. Hungarian biochemist Katalin Karikó — now a senior executive with BioNTech, Pfizer’s partner on the COVID-19 vaccine — started developing mRNA therapies in 1990 while a professor at University of Pennsylvania Medical School.
Claim: Moderna was already producing COVID-19 vaccines before the beginning of the pandemic (Instagram users, 2023-02-09)
Evidence (2021-11-13): Since the beginning of the pandemic, healthcare workers have administered billions of COVID-19 vaccine doses. In this Special Feature, we speak with medical experts about how scientists made coronavirus vaccines so rapidly without compromising safety. [...] The Pfizer and Moderna COVID-19 vaccines were the first mRNA vaccines that humans received outside of clinical trials. [...] The pandemic has ushered in a new era of vaccine research. The combination of the global collaboration of scientists and the development of mRNA vaccines is akin to the "landing-on-the-moon moment," according to Dr. Yager.
Claim: Moderna was already producing COVID-19 vaccines before the beginning of the pandemic (Instagram users, 2023-02-09)
Evidence (2023-10-06): - On Monday, Sept. 11, 2023, the FDA took action authorizing and approving the updated 2023–2024 monovalent XBB.1.5 variant mRNA COVID-19 vaccines by Moderna and Pfizer-BioNTech. On September 12, 2023, CDC recommended use of these updated 2023–2024 COVID-19 vaccines in all individuals ages 6 months and older. [...] With these FDA and CDC actions, the CDC COVID-19 Vaccination Program ended as of September 12, 2023, as it applied to the administration of the bivalent Moderna and Pfizer-BioNTech mRNA COVID-19 vaccines previously provided by the US Government (USG). Now, with FDA’s authorization on October 3, 2023, of the 2023–2024 Novavax COVID-19 Vaccine, Adjuvanted, the CDC COVID-19 Vaccination Program has fully ended as of October 3, 2023. All authorized/approved doses of COVID-19 vaccine in the United States are now the 2023–2024 formulas. [...] Bivalent (Original and Omicron BA.4/BA.5 variant) Moderna and Pfizer-BioNTech mRNA COVID-19 vaccines and ancestral (Original) Novavax COVID-19 vaccines should no longer be administered; 2023-2024 versions should be administered instead.
Claim: Moderna was already producing COVID-19 vaccines before the beginning of the pandemic (Instagram users, 2023-02-09)
Evidence (2020-12-10): The VRC worked with a company called Moderna to use this information to quickly customize their prototype approach to the SARS-CoV-2 spike protein. By early February, a COVID-19 vaccine candidate had been designed and manufactured. This vaccine is called mRNA-1273. By March 16, 2020, this vaccine had entered the first phase of clinical trials. Other vaccines, including a similar one from Pfizer and BioNTech SE, entered clinical trials not long after. On December 18, 2020, after demonstrating 94 percent efficacy, the NIH-Moderna vaccine was authorized by the U.S. Food and Drug Administration (FDA) for emergency use. Just days earlier, the similar Pfizer/BioNTech vaccine had become the first COVID-19 vaccine to be authorized for use in the United States. [...] Moderna, Inc. (n.d.). Moderna’s Work on a COVID-19 Vaccine Candidate. Retrieved December 10, 2020, from https://www.modernatx.com/modernas-work-potential-vaccine-against-covid-19
Claim: Moderna was already producing COVID-19 vaccines before the beginning of the pandemic (Instagram users, 2023-02-09)
Evidence (2023-03-15): Moderna Therapeutics begin the first human trials of a vaccine to protect against COVID-19 at a research facility in Seattle, Washington. [...] Moderna’s COVID-19 vaccine is found to be 95.4% effective in its clinical trial. [...] FDA fully approves the Moderna COVID-19 vaccine for all people ages 18 years and older. Full FDA approval further reinforces that the Moderna COVID-19 vaccine has been shown to meet the agency’s high standards for safety, effectiveness, and consistent quality in manufacturing. To date, COVID-19 vaccines are estimated to have saved at least a quarter of a million lives and prevented more than 1 million hospitalizations.
Claim: Moderna was already producing COVID-19 vaccines before the beginning of the pandemic (Instagram users, 2023-02-09)
Evidence (2024-04-04): Chinese scientists share the first genetic sequence of SARS-CoV-2 with the NIH database GenBank. Scientists from NIH and Moderna quickly pivot from studies of other viral vaccines to focus on a vaccine candidate for COVID-19, mRNA-1273, to respond to the outbreak. Source 1, Source 2 [...] The FDA grants an EUA of the Moderna and Pfizer-BioNTech COVID-19 vaccines to authorize bivalent formulations for use as a booster dose. These updated boosters contain mRNA components for both the original strain of SARS-CoV-2 and its Omicron variant. Source The FDA grants an EUA to the Pfizer-BioNTech and Moderna bivalent COVID-19 vaccines for children age 6 months or older. Source
Claim: Moderna was already producing COVID-19 vaccines before the beginning of the pandemic (Instagram users, 2023-02-09)
Evidence (2022-01-17): Many COVID-19 vaccine clinical trials are in process. Researchers take what was previously learned from vaccine studies of SARS-CoV, MERS-CoV and other viruses to develop vaccines that prevent COVID-19. Researchers also study COVID-19 symptoms, long-term effects, diagnostic tests, antibody tests, treatments and drugs. [...] The FDA gives emergency use authorization to two mRNA COVID-19 vaccines, the Pfizer-BioNTech and the Moderna COVID-19 vaccines. Because there is an urgent need for COVID-19 vaccines and the FDA’s vaccine approval process can take months to years, the FDA first gave emergency use authorization to COVID-19 vaccines based on less data than is normally required. The data must show that the vaccines are safe and effective before the FDA can give emergency use authorization or approval. Vaccines have gone through — and continue to go through — extensive safety monitoring. Millions of COVID-19 vaccines have been given since December 2020. Researchers at Mayo Clinic and other medical centers continue to study more vaccines that prevent COVID-19.
Claim: Moderna was already producing COVID-19 vaccines before the beginning of the pandemic (Instagram users, 2023-02-09)
Evidence (2021-08-03): According to data by the CDC, Moderna’s COVID-19 vaccine induces rare anaphylactic reactions in a small number of people, similar to that found in recipients of the Pfizer/BioNTech vaccine. Reported by STAT, the CDC estimated a prevalence of 2.1 cases of anaphylaxis per million doses of the Moderna vaccine and 6.2 cases per million doses of the Pfizer vaccine. [...] Moderna will test 2 COVID-19 booster shots designed to be more effective against emerging variants, with one targeting the South African variant and the other to fight new mutations. The move comes amid reports that its approved vaccine was less potent against the variant identified in South Africa. [...] A small number of people who received Moderna’s COVID-19 vaccine experienced delayed, large, localized skin irritations around the injection site. Although the symptoms were reported to have cleared up in a median of 8 days, physicians should be made aware about the potential adverse effect in order to navigate proper treatment and guidance, according to researchers.
Claim: Moderna was already producing COVID-19 vaccines before the beginning of the pandemic (Instagram users, 2023-02-09)
Evidence (2021-09-14): Hundreds of scientists had worked on mRNA vaccines for decades before the coronavirus pandemic brought a breakthrough. [...] The lightning-fast quest for COVID vaccines — and what it means for other diseases CureVac COVID vaccine let-down spotlights mRNA design challenges
Claim: Moderna was already producing COVID-19 vaccines before the beginning of the pandemic (Instagram users, 2023-02-09)
Evidence (2024-10-08): Guidance for adults who have had a COVID-19 vaccine before [...] - Get 1 dose of the 2024-2025 Moderna or Pfizer-BioNTech COVID-19 vaccine, or - Get 2 doses of the 2024-2025 Novavax COVID-19 vaccine at least 3 weeks apart [...] If you have had a COVID-19 vaccine before, get 1 dose of the 2024-2025 Moderna, Pfizer-BioNTech, or Novavax vaccine. You may also be eligible to get additional doses of one of these vaccines. Ask your provider how many doses they recommend for you.
Claim: Moderna was already producing COVID-19 vaccines before the beginning of the pandemic (Instagram users, 2023-02-09)
Evidence (2023-04-06): Moderna’s CEO said in January that the company’s total production in 2019 was "100,000 dose," referring to all its vaccines and therapeutics. Online posts distorted the remarks to falsely claim Moderna made COVID-19 vaccines "before the pandemic started." Moderna’s first batch of COVID-19 vaccines wasn’t ready until February 2020. [...] But social media posts misrepresented Bancel’s remarks, falsely claiming that he said the company was making the vaccine before the pandemic was recognized. "URGENT — Moderna CEO Stéphane Bancel Admits Company Produced 100,000 COVID-19 Doses in 2019 Before The Pandemic Started," read an Instagram post on Feb. 9. [...] Reuters Fact Check. "Fact Check-Moderna CEO did not say company made 100,000 COVID-19 vaccine doses before the pandemic started." Reuters. 10 Feb 2023.
Claim: Moderna was already producing COVID-19 vaccines before the beginning of the pandemic (Instagram users, 2023-02-09)
Evidence (2023-03-10): The federal government has so far purchased 1.2 billion doses of Pfizer and Moderna COVID-19 vaccines combined, at a cost of $25.3 billion, or a weighted average purchase price of $20.69 per dose. In mid-2020, months before any COVID-19 vaccine was yet authorized or had even completed clinical trials, the federal government purchased an initial 200 million vaccine doses from Pfizer and Moderna (100 million each), at a price of $19.50 per dose and $15.25 per dose, respectively. This guaranteed an advance market for these vaccines, should they prove safe and effective and receive emergency use authorization (EUA) from the Food and Drug Administration (FDA), as each did in December 2020. In total, the federal government has made six different bulk purchases from Pfizer, totaling 655 million doses, and five bulk purchases from Moderna, totaling 566 million doses, for a total of 1.2 billion doses. Subsequent federal government purchases were made at a higher price per dose, with a weighted average across these purchases of $20.69. (See Figure 1 below and Tables in Appendix.) [...] - https://www.medicalcountermeasures.gov/app/barda/coronavirus/covid19.aspx - https://www.medicalcountermeasures.gov/newsroom/2020/modernamanufacturing - https://investors.modernatx.com/news/news-details/2020/Moderna-Announces-Supply-Agreement-with-U.S.-Government-for-Initial-100-Million-Doses-of-mRNA-Vaccine-Against-COVID-19-mRNA-1273/default.aspx - https://www.medicalcountermeasures.gov/newsroom/2020/moderna/ [...] - https://investors.modernatx.com/news/news-details/2021/U.S.-Government-Purchases-Additional-100-Million-Doses-of-Modernas-COVID-19-Vaccine/default.aspx - https://investors.modernatx.com/news/news-details/2021/U.S.-Government-Purchases-Additional-200-Million-Doses-of-Modernas-COVID-19-Vaccine/default.aspx - https://www.hhs.gov/about/news/2022/07/29/biden-harris-administration-secures-66-million-doses-modernas-variant-specific-covid-19-vaccine-booster-for-potential-use-in-fall-winter-2022.html