copenlu/druid huggingface dataset:
Claim: AIDS was cured in more than a dozen patients (Alfredo Bowman, 2019-04-01)
Evidence (2020-03-10): With second patient cured of HIV, doctors seek clues to a future AIDS treatment [...] Twelve years passed after the announcement of the Berlin patient's cure, and those were years spent wondering whether Brown had benefited from a freak accident of treatment, Johnston said.
Claim: AIDS was cured in more than a dozen patients (Alfredo Bowman, 2019-04-01)
Evidence (2024-07-18): A German man has probably been cured of HIV, a medical milestone achieved by only six other people in the more than 40 years since the AIDS epidemic began. [...] As with all previous cases of potential HIV cure, experts are eager to temper public excitement with a caveat: The treatment that apparently thwarted the virus in the seven patients will ever be available to only a select few. All contracted HIV and later developed blood cancer, which demanded stem cell transplants to treat the malignancy. [...] In five of the seven cases of definite or possible HIV cure, doctors found donors who had rare, natural defects in both copies of a gene that gives rise to a particular protein, called CCR5, on the surface of immune cells. Most HIV strains attach to that protein to infect cells. Without functional CCR5 proteins, immune cells are HIV-resistant.
Claim: AIDS was cured in more than a dozen patients (Alfredo Bowman, 2019-04-01)
Evidence (2024-07-26): Seventh patient ‘cured’ of HIV: why scientists are excited
Claim: AIDS was cured in more than a dozen patients (Alfredo Bowman, 2019-04-01)
Evidence (2024-09-10): Berlin patient – The first known case of HIV cure was Timothy Ray Brown, who had been living with HIV for over a decade when he developed acute myeloid leukemia. He received chemotherapy, total body irradiation, and two stem cell transplants. Each transplant came from the same donor, who had the CCR5 delta32 genetic mutation. The case was published in 2009 and was subject to intense scrutiny before scientists agreed he was likely cured. Although he remained free of any signs of HIV infection, Timothy passed away in September 2020 following a relapse of his leukemia. [...] Second Berlin patient – Researchers at AIDS 2024 announced that an adult German male born in 1964, who wishes to remain anonymous, likely joins the six other individuals listed above who have been cured by a stem cell transplant. The second Berlin Patient provides new evidence that the CCR5 delta32 gene mutation might not be the only path to a cure. The patient has been in sustained HIV remission for five and a half years without ART after a stem cell transplant of donor cells with only a single "heterozygous" gene mutation for CCR5. In this case, the donor cells were fully susceptible to HIV infection, but the research team could find no residue of HIV after years of monitoring. Researchers are now investigating what healing mechanisms may be at work in this case.
Claim: AIDS was cured in more than a dozen patients (Alfredo Bowman, 2019-04-01)
Evidence (2022-10-05): Scientists have cured a handful of people of HIV by piggybacking on treatments they received for blood cancer. But does that bring a widespread cure any closer? Over the past year, news of two new people cured of HIV grabbed headlines, stirring hopeful talk of what these scientific wonders might portend for the four-decade fight against the virus. [...] In July, at the International AIDS Conference in Montreal, researchers announced the case of a fifth person possibly cured of HIV. Diagnosed with the virus in 1988 and 63 years old at the time of his stem cell transplant three years ago, the American man is the oldest to have achieved potential success with such a treatment and the one living with the virus for the longest. Because of his age, he received reduced intensity chemotherapy to treat his AML. Promisingly, he still beat both the cancer and the virus.
Claim: AIDS was cured in more than a dozen patients (Alfredo Bowman, 2019-04-01)
Evidence (2022-07-27): A man who has lived with HIV since the 1980s seems to have been cured in only the fourth such case, say doctors. [...] She said there had been a "handful of individual cure cases before" and they provided "continued hope for people living with HIV, and inspiration for the scientific community."
Claim: AIDS was cured in more than a dozen patients (Alfredo Bowman, 2019-04-01)
Evidence (2020-03-10): Second patient cured of HIV, say doctors [...] In 2011, Timothy Brown, the "Berlin Patient" became the first person reported as cured of HIV, three and half years after having similar treatment.
Claim: AIDS was cured in more than a dozen patients (Alfredo Bowman, 2019-04-01)
Evidence (2022-07-27): Two new cases presented Wednesday at the International AIDS Conference in Montreal have advanced the field of HIV cure science, demonstrating yet again that ridding the body of all copies of viable virus is indeed possible, and that prompting lasting viral remission also might be attainable. [...] Over four decades, just five people have been cured or possibly cured of HIV. [...] The first person cured of HIV was the American Timothy Ray Brown, who, like the City of Hope patient, was diagnosed with AML. His case was announced in 2008 and then published in 2009. Two subsequent cases were announced at a conference in 2019, known as the Düsseldorf and London patients, who had AML and Hodgkin lymphoma, respectively. The London patient, Adam Castillejo, went public in 2020.
Claim: AIDS was cured in more than a dozen patients (Alfredo Bowman, 2019-04-01)
Evidence (2018-10-24): Weill Cornell Medicine’s more than 30 years of HIV/AIDS clinical trial expertise will be particularly helpful in advancing work the team is doing with the Believe in a Cure Martin Delaney Collaboratory funded by a $28 million grant from the National Institutes of Health. The NIH awards the highly competitive grant to investigators with proven experience in innovative vaccine and immunotherapy research. Dr. Nixon is the principal investigator of the project and he and Dr. Jones collaborate with more than a dozen other scientists from Mexico, Canada and Brazil to find and advance the most promising approaches to an HIV cure. Existing therapies for HIV can keep the virus in check and eliminate many of the symptoms associated with advanced AIDS, but if patients stop taking the medications the virus and symptoms come back. A cure would completely eliminate the virus or prevent it from causing symptoms, and may allow patients to discontinue HIV medications and avoid their side effects.
Claim: AIDS was cured in more than a dozen patients (Alfredo Bowman, 2019-04-01)
Evidence (2010-01-21): The neglected tropical diseases (NTDs) represent a group of more than a dozen major chronic infectious diseases, most of them parasitic infections, with high endemicity in the developing countries of Africa, Asia, and the Americas. The conceptual framework of the NTDs was formulated in the years following the 2000 launch of the Millennium Declaration (Hotez, 2006, 2008a, 2011; Hotez et al., 2006a, 2007; Molyneux et al., 2005). Both the Millennium Declaration and its eight Millennium Development Goals (MDGs) for sustainable poverty reduction were instrumental in shaping global health policy over the next decade, and they provided a platform and basis for large-scale donor support from both public and private sources. Indeed, MDG 6, "to combat AIDS, malaria, and other diseases," helped to galvanize a new awareness for the impact of HIV/AIDS, malaria, and to some extent tuberculosis and stimulated the establishment of the Global Fund to Fight AIDS, Tuberculosis and Malaria (GFATM), the U.S. President's Emergency Plan for AIDS Relief (PEPFAR), and the U.S. President's Malaria Initiative (Hotez, 2011), in addition to increased research and development support from the National Institutes of Health and the Bill & Melinda Gates Foundation, among others.
Claim: AIDS was cured in more than a dozen patients (Alfredo Bowman, 2019-04-01)
Evidence (2022-02-16): An American research team reported that it has possibly cured HIV in a woman for the first time. Building on past successes, as well as failures, in the HIV-cure research field, these scientists used a cutting-edge stem cell transplant method that they expect will expand the pool of people who could receive similar treatment to several dozen annually. Their patient stepped into a rarified club that includes three men whom scientists have cured, or very likely cured, of HIV. Researchers also know of two women whose own immune systems have, quite extraordinarily, apparently vanquished the virus. [...] In the first case of what was ultimately deemed a successful HIV cure, investigators treated the American Timothy Ray Brown for acute myeloid leukemia, or AML. He received a stem cell transplant from a donor who had a rare genetic abnormality that grants the immune cells that HIV targets natural resistance to the virus. The strategy in Brown’s case, which was first made public in 2008, has since apparently cured HIV in two other people. But it has also failed in a string of others.
Claim: AIDS was cured in more than a dozen patients (Alfredo Bowman, 2019-04-01)
Evidence (2018-10-29): Nixon is the principal investigator of the project; he and Jones collaborate with more than a dozen other scientists from Mexico, Canada and Brazil to find and advance the most promising approaches to an HIV cure. Existing therapies for HIV can keep the virus in check and eliminate many symptoms associated with advanced AIDS, but if patients stop taking the medications, the virus and symptoms come back. A cure would completely eliminate the virus or prevent it from causing symptoms, and may allow patients to discontinue HIV medications and avoid their side effects.
Claim: AIDS was cured in more than a dozen patients (Alfredo Bowman, 2019-04-01)
Evidence (2023-01-20): The FDA has approved more than two dozen antiretroviral drugs to treat HIV infection. They're often broken into six groups because they work in different ways. Doctors recommend taking a combination or "cocktail" of at least two of them. This is called antiretroviral therapy, or ART.
Claim: AIDS was cured in more than a dozen patients (Alfredo Bowman, 2019-04-01)
Evidence (2011-07-12): "A critical factor to finding a cure for AIDS is to solve the problem of HIV latency," said Warner Greene, MD, PhD who leads all virology and immunology research at Gladstone. "If we can inhibit latency, then a cure for HIV-infected patients could be within our reach." AIDS has killed more than 25 million people around the world since first being identified some 30 years ago. In the United States alone, more than one million people live with HIV/AIDS at an annual cost of $34 billion. Patients require lifelong treatment for AIDS because the HIV virus persists in a dormant and drug-insensitive form. Better understanding this latency, and developing new ways to attack it, could finally make it possible to cure HIV-infected patients.
Claim: AIDS was cured in more than a dozen patients (Alfredo Bowman, 2019-04-01)
Evidence (2014-11-01): While the intensive virostatic combinations applied according to the conventional models (such as HAART), based only on the attacks of two HIV-1 targets, retrotranscriptase and protease, and applied in a long and continuous fashion, a) are notably toxic, b) do not correct completely the abnormal immunologic parameters, and c) are followed by particularly severe and poorly sensitive relapses in case of discontinuation, we propose to the 'AIDS treatment headquarters' to include in their failing strategy the two original features which we have included in the treatment of a cohort of a dozen patients, treatment applied at all but one AIDS stage. We attack one more HIV-1 target than the conventional protocols do, by adding inhibitors of integrase; we apply the combinations of virostatics, comprising inhibitors of the three targets, in short sequences (of 3 weeks), between which the analogues are changed inside each series. The first patient of the cohort started his treatment 8.5 years ago, and the entries of the others into it have been at random and not randomized. All patients are alive today and in excellent condition.
Claim: AIDS was cured in more than a dozen patients (Alfredo Bowman, 2019-04-01)
Evidence (2024-07-30): The first person to be cured of HIV was Timothy Ray Brown, an American who received a pioneering stem cell transplant back in 2007, six years before Franke. There are now seven patients who have been cured. The latest case was revealed at AIDS 2024, the 25th International AIDS Conference, in Munich last week, although this patient has requested anonymity. [...] Finally, and most important, in many cases, such stem cell transplants do not eliminate the virus from the body. An international collaboration called IciStem has begun collecting tissue from the dozens of HIV patients who have received such transplants. The goal is to understand more about why individuals like Franke have been cured while others were not. "The question is why was it successful in these seven cases?" says Christian Gaebler, the doctor at Berlin’s Charité hospital who presented data on the latest patient to be cured at AIDS 2024. "Were there features in the patient which gave them a better starting point to achieve HIV remission or was there something unique about the immune responses of the donor, which created a better chance of depleting these HIV reservoirs."
Claim: AIDS was cured in more than a dozen patients (Alfredo Bowman, 2019-04-01)
Evidence (2024-02-08): As of 2022, PEPFAR has enabled more than a dozen countries to control the spread of HIV or reach the Joint United Nations Programme on HIV/AIDS (UNAIDS) 2025 AIDS targetsExit Disclaimer, even without a vaccine or a cure, advancing global progress toward achieving the UN Sustainable Development Goal of ending the AIDS epidemic as a public health threat by 2030.
Claim: the IPCC is wrong − the sun, not CO2, drove modern global warming (Roger Higgs, 2020-03-11)
Evidence (2020-03-11): This article presents a long list of inaccurate claims, but focuses on the idea that the Sun—rather than human-caused greenhouse gas emissions—is responsible for global warming. The available evidence and research clearly shows that this claim is incorrect. Measured patterns of warming, and monitoring of incoming solar energy, rule out the Sun as the source of warming.
Claim: the IPCC is wrong − the sun, not CO2, drove modern global warming (Roger Higgs, 2020-03-11)
Evidence (2021-08-09): The report shows that emissions of greenhouse gases from human activities are responsible for approximately 1.1°C of warming since 1850-1900, and finds that averaged over the next 20 years, global temperature is expected to reach or exceed 1.5°C of warming. This assessment is based on improved observational datasets to assess historical warming, as well progress in scientific understanding of the response of the climate system to human-caused greenhouse gas emissions. [...] The report also shows that human actions still have the potential to determine the future course of climate. The evidence is clear that carbon dioxide (CO2) is the main driver of climate change, even as other greenhouse gases and air pollutants also affect the climate. [...] Thousands of people from all over the world contribute to the work of the IPCC. For the assessment reports, IPCC scientists volunteer their time to assess the thousands of scientific papers published each year to provide a comprehensive summary of what is known about the drivers of climate change, its impacts and future risks, and how adaptation and mitigation can reduce those risks.
Claim: the IPCC is wrong − the sun, not CO2, drove modern global warming (Roger Higgs, 2020-03-11)
Evidence (2022-04-04): Global emissions of CO2 would need to peak within three years to stave off the worst impacts. [...] To avoid that fate, the world must keep the rise in temperatures at or under 1.5C this century, say researchers. [...] To put it in context, the amount of CO2 that the world has emitted in the last decade is the same amount that's left to us to stay under this key temperature threshold.
Claim: the IPCC is wrong − the sun, not CO2, drove modern global warming (Roger Higgs, 2020-03-11)
Evidence (2021-08-09): Today, the Intergovernmental Panel on Climate Change (IPCC) released the Physical Science Basis report from Working Group 1, a major part of their sixth Assessment Report. This report includes the most up-to-date understanding of the climate system and climate change, providing the best scientific evidence in order to understand the past, present, and future changes to our planet from global warming. The conclusions are clear: climate change is already affecting nearly every part of the planet, and human activities are unequivocally the cause. The report, co-authored by 234 scientists from around the world, finds that we are now around 2.0°F (1.1°C) warmer than in 1850-1900, warming at a rate without precedent in at least 2000 years, possibly longer. This report confirms that the climate-driven changes occurring around the world are widespread, rapid, and intensifying. Our influence on the climate is making extreme weather and climate events—like heat waves, heavy rain, and droughts—more frequent and severe, putting more people, property, and natural resources in harm’s way. Unless there is a rapid and large-scale reduction in greenhouse gas emissions, limiting warming to a 2.7°F (1.5°C) threshold will be beyond reach. Scientists warn that the more humans drive Earth’s average temperature above this threshold, the more frequent and severe extreme weather and climate events will become.
Claim: the IPCC is wrong − the sun, not CO2, drove modern global warming (Roger Higgs, 2020-03-11)
Evidence (2021-10-28): The recently published Intergovernmental Panel for Climate Change (IPCC) Synthesis Report, says "it is unequivocal that human influence has warmed the atmosphere, ocean and land", and warns that the Paris Agreement goals of 1.5°C and 2°C above pre-industrial levels will be exceeded during this century without dramatic emissions reductions. [...] Read more: 99.999% certainty humans are driving global warming: new study [...] If human factors are removed from the data set and only volcanic and solar factors are included, then global average surface temperatures since 1950 should have remained similar to those over the preceding 100 years. But of course they haven’t.
Claim: the IPCC is wrong − the sun, not CO2, drove modern global warming (Roger Higgs, 2020-03-11)
Evidence (2020-08-27): The accumulation of carbon dioxide in the atmosphere, caused primarily by the burning of fossil fuels, had been worrying scientists since the 1970s. The discovery of the "ozone hole" above Antarctica had given atmospheric scientists enormous credibility and clout among the public, and an international treaty banning chlorofluorocarbons, the chemicals causing the problem, was swiftly signed. [...] Thanks to COVID-19, the next IPCC assessment report probably won’t be delivered before the delayed conference in Glasgow at the end of 2021. There probably won’t be anything in it that tells us more than what we already know – CO₂ levels are rising, the consequences are piling up, and campaigns for delaying meaningful action have been spectacularly successful for the last 30 years. Some scientists, including Columbia University professor James Hansen, argue that the agonising efforts of scientists to avoid provoking accusations of alarmism have led to an innate optimism bias. The official science reported by the IPCC may in some cases be a cautious underestimate. It’s likely worse – much worse – than we think.
Claim: the IPCC is wrong − the sun, not CO2, drove modern global warming (Roger Higgs, 2020-03-11)
Evidence (2023-12-01): The world is already more than 1 °C warmer on average than it was before industrial times, owing to greenhouse gases released from human activities. And that value is rising. The Intergovernmental Panel on Climate Change (IPCC) projects that there is at least a 50% chance that long-term global warming will overshoot 1.5 °C in the next decade, even with ambitious emissions cuts. [...] Source: analysis by R. A. Betts et al. [...] We encourage the IPCC to tackle this issue in a Special Report ahead of its seventh assessment report (AR7), which is not expected to be published until about 2030 — by which time, global warming might already have exceeded 1.5 °C or be close to doing so.
Claim: the IPCC is wrong − the sun, not CO2, drove modern global warming (Roger Higgs, 2020-03-11)
Evidence (2022-02-28): This report from the IPCC is the second of three reviews from the world's foremost body of climate researchers. [...] But the authors say that there is still a brief window of time to avoid the very worst. [...] The report is disdainful of technological fixes like deflecting the Sun's rays or removing carbon dioxide from the air, saying they could make things worse.
Claim: the IPCC is wrong − the sun, not CO2, drove modern global warming (Roger Higgs, 2020-03-11)
Evidence (2021-01-01): Human activities have Earth's climate by more than 1°C since the late 19th century, and the effects on our climate are . We are increasingly feeling the consequences in every inhabited , and the changes we experience become the more the Earth warms. People in all regions will be affected in ways. We're already seeing more severe and frequent . Future emissions will determine global warming. With higher emissions, becomes less efficient in absorbing the carbon we emit. Some changes cannot be avoided, but by limiting warming we can , and even stop, many of them. The is that reducing our emissions quickly can limit global warming.
Claim: the IPCC is wrong − the sun, not CO2, drove modern global warming (Roger Higgs, 2020-03-11)
Evidence (2021-08-09): IPCC climate report: Earth is warmer than it’s been in 125,000 years Landmark assessment says that greenhouse gases are unequivocally driving extreme weather — but that nations can still prevent the worst impacts. [...] Modern society’s continued dependence on fossil fuels is warming the world at a pace that is unprecedented in the past 2,000 years — and its effects are already apparent as record droughts, wildfires and floods devastate communities worldwide — according to a landmark report from the United Nations on the state of climate science. The assessment from the UN’s Intergovernmental Panel on Climate Change (IPCC) says things are poised to get worse if greenhouse-gas emissions continue, and makes it clear that the future of the planet depends, in large part, on the choices that humanity makes today.
Claim: the IPCC is wrong − the sun, not CO2, drove modern global warming (Roger Higgs, 2020-03-11)
Evidence (2022-04-04): GENEVA, Apr 4 – In 2010-2019 average annual global greenhouse gas emissions were at their highest levels in human history, but the rate of growth has slowed. Without immediate and deep emissions reductions across all sectors, limiting global warming to 1.5°C is beyond reach. However, there is increasing evidence of climate action, said scientists in the latest Intergovernmental Panel on Climate Change (IPCC) report released today. [...] The Intergovernmental Panel on Climate Change (IPCC) is the UN body for assessing the science related to climate change. It was established by the [...] Thousands of people from all over the world contribute to the work of the IPCC. For the assessment reports, experts volunteer their time as IPCC authors to assess the thousands of scientific papers published each year to provide a comprehensive summary of what is known about the drivers of climate change, its impacts and future risks, and how adaptation and mitigation can reduce those risks.