Question: What makes a molecule amphiphilic?
About the article "Biochemistry", section "Lipids_1".

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 Janus-faced molecule, used to describe a molecule whose effects on organisms can vary between beneficial and toxic Janus particles, amphiphilic particles having one half hydrophilic and the other half hydrophobic Janus Experiments, a series of experiments on radio-sensitivity in mice and dogs Janus kinase, an intracellular signaling molecule; component of the JAK-STAT signal system  
A Langmuir monolayer or insoluble monolayer is a one-molecule thick layer of an insoluble organic material spread onto an aqueous subphase.
Traditional compounds used to prepare Langmuir monolayers are amphiphilic materials that possess a hydrophilic headgroup and a hydrophobic tail.
Since the 1980s a large number of other materials have been employed to produce Langmuir monolayers, some of which are semi-amphiphilic, including macromolecules such as polymers.
Langmuir monolayers are extensively studied for the fabrication of Langmuir-Blodgett film (LB films), which are formed by transferred monolayers on a solid substrate.
A Gibbs monolayer or soluble monolayer is a monolayer formed by a compound that is soluble in one of the phases separated by the interface on which the monolayer is formed. 
Amphiphile (from the Greek αμφις, amphis: both and φιλíα, philia: love, friendship) is a term describing a chemical compound possessing both hydrophilic ("water-loving", polar) and lipophilic ("fat-loving") properties.
Such a compound is called "amphiphilic" or "amphipathic."
This forms the basis for a number of areas of research in chemistry and biochemistry, notably that of lipid polymorphism.
Organic compounds containing hydrophilic groups at both ends of a prolate molecule are called bolaamphiphilic.
Common amphiphilic substances are soaps, detergents and lipoproteins. 
Surface pressure can also refer to the change of surface tension as a function of the area of water surface available to each molecule in a solution.
The measurement of surface pressure is key in determining the monolayer properties of an amphiphilic material.
The surface pressure describes the depression of the surface tension below the value for an uncontaminated interface.
See also: Pressure: Surface pressure. 
The FluidCrystal NP delivery system can be administered via injection, transdermally, or orally.
The nanoparticle system allows for high drug payloads.
In addition, the unique liquid crystal interior combined with the large exterior surface area makes the particles suitable for transporting amphiphilic and lipophilic drug compounds that would normally suffer from solubility issues.
This delivery system also serves to encapsulate fragile peptide and protein compounds.
The transdermal delivery route specifically improves the availability of small molecule drugs and peptides by facilitating efficient transport across the dermis.
Finally, the oral delivery route improves the availability of small molecule drugs and peptides by preventing their degradation in the gastrointestinal transport.
In addition, the system offers controlled release of the drug compound to improve absorption and pharmacokinetics.