Question: Who first applied chemical theory?
About the article "Chemical reaction", section "History".

Candidate passages:
The first development of "quantum electrochemistry" is somewhat difficult to pin down.
This is not very surprising, since the development of quantum mechanics to chemistry can be summarized as the application of quantum wave theory models to atoms and molecules.
This being the case, electrochemistry, which is particularly concerned with the electronic states of some particular system, is already, by its nature, tied into the quantum mechanical model of the electron in quantum chemistry.
There were proponents of quantum electrochemistry, who applied quantum mechanics to electrochemistry with unusual zeal, clarity and precision.
Among them were Revaz Dogonadze and his co-workers.
They developed one of the early quantum mechanical models for proton transfer reactions in chemical systems.
Dogonadze is a particularly celebrated promoter of quantum electrochemistry, and is also credited with forming an international summer school of quantum electrochemistry centered in Yugoslavia.
He was a main author of the "Quantum-Mechanical Theory of Kinetics of the Elementary Act of Chemical, Electrochemical and Biochemical Processes in Polar Liquids".
Another important contributor is Rudolph A. Marcus, who won the Nobel Prize in Chemistry in 1992 for his "Theory of Electron Transfer Reactions in Chemical Systems". 
The Herman Skolnik Award is awarded annually by the Division of Chemical Information of the American Chemical Society, "to recognize outstanding contributions to and achievements in the theory and practice of chemical information science".
the award is of 3,000 US dollars.
It is named for Herman Skolnik (1914-1994), who was a co-founder of the then ACS Division of Chemical Literature in 1948 and a key figure in the Division.
The first award was made to him. 
Canonical Theory (also named the "canonical form") is a molecular theory developed by Joel E. Keizer and coworkers which claims to explain many physical, chemical, and biological processes in an unified and canonical way.
Ronald F. Fox and Keizer showed the application of the canonical theory to chaos.
Keizer used the canonical form for the first formulation of statistical thermodynamics valid in far from equilibrium regimes, where the Onsager reciprocal relations and the Einstein formula for the fluctuations do not work.
Keizer also provided fluctuating generalizations of the Boltzmann equation and of hidrodynamics (fluctuating hydrodynamics).
The applications of his work to biology are the reason that he was considered as one of the pioneers in the field of computational biology.
Cosma Shalizi wrote: ""Chapter five applies the canonical theory to various chemical and electrochemical processes.
There is a detailed comparison of a model based on the formalism to actual experimental data for a calcium-regulated potassium channel in muscle cells, yielding remarkably close agreement (especially since the channel is really just a single molecule!)...
Keizer was, until his premature death in May, 1999, an active and talented scientist who played a significant role not merely in the development of the formal structure of far from equilibrium thermodynamics, but also in its application to experiment, especially in biology.
Unlike a number of others who have attempted such cross-overs, he made it work".
"Besides the unification of disparate topics as chemical reactions, hydrodynamics, or heat transport in solids, the canonical theory has been applied to solving the problems of traditional disciplines as statistical mechanics. 
Kier built one of the first models in which molecular orbital theory was applied successfully to drug design and development.
In this model, he and his colleague developed what is now called the "Kier-Hall Index" to describe molecular connectivity.
His particular expertise in the question “How do chemical modifications affect particular physical properties of drugs?” has been used to develop the theory of the interaction of general anesthetic gases with the body, and the theory of taste (and in particular, sweetness).
Professor Kier is the author or co-author of eight books: "Molecular Orbital Theory In Drug Research;" "Molecular Connectivity In Chemistry and Drug Research;" "Molecular Connectivity in Structure Activity Analysis;" "Molecular Structure Description: The Electrotopological State;" "Medicinal Chemistry and Physics for Nurse Anesthetists; " "Cellular Automata Modeling of Chemical Systems;" and "Science and Complexity for Life Science Students."
The theory of dosage, set, and setting is a useful model in dealing with the effects of psychoactive substances, especially in a controlled therapeutic setting as well as in recreational use.
Dr. Timothy Leary, based on his own experiences and systematic observations on psychedelics, developed this theory along with his colleagues Ralph Metzner, and Richard Alpert (Ram Dass) in the 1960s.
Dosage The first factor, dosage, has been a truism since ancient times, or at least since Paracelsus who said, "Dose makes the poison."
Some compounds are beneficial or pleasurable when consumed in small amounts, but harmful, deadly, or evoke discomfort in higher doses.
Set The set is the internal attitudes and constitution of the person, including their expectations, wishes, and fears.
This factor is especially important for the hallucinogens, which have the ability to make conscious experiences out of the unconscious.
In traditional cultures, set is shaped primarily by the worldview that all the members of the culture share.
Setting The third aspect is setting, which pertains to the surroundings, the place, and the time in which the experiences transpire.
This theory clearly states that the effects are equally the result of chemical, pharmacological, psychological, and physical influences.
The model that Timothy Leary proposed applied to the psychedelics, although it also applies to other psychoactives.