This is a by-product of abnormal energy production by the cells. It may be caused by damage to the mitochondria. See Fact Sheet 554 for more information on mitochondrial toxicity . Lactic acidosis can cause severe damage to the pancreas and liver. Symptoms of lactic acidosis can include weight loss, abdominal pain, and severe fatigue.
T is more effective if taken with other antiviral drugs.
Pregnant women should not take d4T and ddI at the same time due to an increased risk of lactic acidosis.