Microscopic examination of a tissue specimen from a person with sarcoidosis reveals granulomas. These granulomas may eventually disappear completely or become scar tissue. Granulomas commonly appear in the lymph nodes, lungs, liver, eyes, and skin, and less often in the spleen, bones, joints, skeletal muscles, heart, and nervous system. Symptoms Many people with sarcoidosis have no symptoms, and the disease is discovered during a chest x-ray that's being taken for other reasons. Most people develop minor symptoms that don't progress.
Serious symptoms are rare.
The symptoms of sarcoidosis vary greatly according to the site and extent of the disease. Fever, weight loss, and aching joints may be the first indications of a problem. Enlarged lymph nodes are common but don't often cause symptoms. A fever may recur throughout the illness. The organ most affected by sarcoidosis is the lung.