The plaques are too small to be visualized in the brain of the living human being. The voxel size required to optimally visualize the plaques is 40 m x 40 m x 40 m. To distinguish plaques from blood vessels we produced a 3D view of the tissue slab. The remaining brain tissue has been rendered transparent. The solid yellow line represents the path of a vessel.
Yellow dots represent the individual plaques.
Viewing the volume from different angles help distinguish plaques from vessels. A quicktime animation of the volume is motion is available. The figure below shows such a comparison. MRM can be recognized on the Microwave King Silver stained section.