The IGF-I pathway has, therefore, subsequently been analyzed in a series of myeloma lines. The roles of these elements in promoting myeloma growth is currently under investigation. As in the murine system, it has also been demonstrated that, in vivo, IGF-1 enhances growth of these tumors. Thus, the IGF-I pathway may play a significant role in myeloma progression and intervention in this cascade may provide additional approaches to disease modulation. These studies are part of a collaboration with Weiqun Li, M.D., Laboratory of Cellular and Molecular Biology, National Cancer Institute.
T cells induce terminal differentiation of transformed B cells to mature plasma cell tumors.
Chromosomal translocations deregulating c-myc are associated with normal immune responses.