Departmental Intranet Access your Outlook Mailbox Dept. He has demonstrated that mature B and T lymphocytes proceed spontaneously into apoptosis unless apoptosis is inhibited by external agents, which include ligands for CD40 or the IL-4 receptor.
Single base changes profoundly alter activity.
Mitogenic activity is enhanced by simultaneous inhibition of apoptosis. Closely related motifs block the effects of stimulatory motifs. The mechanism of action of these inhibitory oligonucleotides is the focus of current research. J. Minn. Acad. Yi, A., Chang, M., Peckham, D.W., Krieg, A.M., and Ashman, R.F. CpG Oligodeoxyribonucleotides Rescue Mature Spleen B Cells From Spontaneous Apoptosis and Promote Cell Cycle Entry.