We investigate organic structures and reactions using both organic synthesis and computational chemistry.
Synthetic results lead to improved calculations, which then inspire new experiments.
This should lead to a better understanding of selectivity and to the design of new reagents. These are applied to problems of drug design, especially the structure and activity of peptides and constrained analogues. Rapid conformation searching. Soc., Perkin Trans. Genetic Algorithms in Conformational Analysis J. Chem.