Osteosarcomas tend to metastasize to the lungs, but respiratory distress may not develop for months. Decreased appetite and decreased desire for physical activity are additional signs. Radiographs to include at least two views of the suspected site. Fine needle aspiration or surgical biopsy may also be used to diagnose osteosarcoma. Chest x-ray and or bone scans may be in order to determine if metastasis has occurred.
Successful treatment includes control of the primary tumor as well as prevention of metastasis.
The standard treatment for osteosarcoma of a leg bone is amputation of that leg. Even large and giant breeds can function well after limb amputation and most owners are pleased with their dog's mobility and quality of life after this surgery. In addition to surgery, chemotherapy involving a combination of drugs may be prescribed. Commonly used drugs are adriamycin, vincristine, cytoxan and cisplatin. Cisplatin and adriamycin are the most effective.