Hormonal therapy Hormones, particularly progesterone, can be used to treat metastatic endometrial cancer, but their effectivness is not very great. Back to Top Chemotherapy Studies have not yet produced clear results on the effectiveness of chemotherapy to treat endometrial cancer. Chemotherapy is potentially most useful for cancers that have spread to distant parts of the body. Stages I and II Hysterectomy and bilateral salpingo-oophorectomy plus radiation, depending on the grade of the tumor and whether it has invaded the myometrium. Usually there is a low risk of disease recurrence, therefore radiation therapy is not used.
Treatment is surgery only.
There is an intermediate risk for disease recurrence in these patients, although it is not clear that postoperative radiation therapy improves survival. It does, however, decrease the risk of local relapse. Following surgery, it is important that patients be given the opportunity to participate in clinical, postoperative radiation therapy trials. Following surgery, vaginal cuff radiotherapy with or without pelvic or whole abdominal radiation may increase a woman's chances of survival. Progesterone is used for metastatic endometrial cancer.