Using the patch clamp recording technique, we have characterized a number of voltage-dependent ion channels in dissociated taste receptor cells from the rat tongue and investigated how these currents are modulated by the cyclic AMP and the inositol trisphosphate second messenger systems. Additionally, we have recently identified the neuropeptide cholecystokinin within some taste cells within the taste bud and demonstrated that its release affects the electrical excitability of taste cells. We are pursuing many of these observations with modern molecular techniques. Electrophysiological actions of quinine on dissociated rat taste receptor cells. Cyclic AMP and forskolin inhibit potassium currents in rat taste cells by different mechanisms.
Serotonin inhibits calcium-activated potassium currents in rat taste receptor cells.
Cellular Mechanisms of Taste Transduction. Characterization of chloride currents and their noradrenergic modulation in rat taste receptor cells.