He was a Research Associate at University of Rochester and Stanford University. He joined the Laboratory of Molecular Biology in 1971. In 1994, Dr. Adhya was elected a member of the National Academy of Sciences. Dr. Adhya has also been an AdjunctProfessor in the Department of Genetics at George Washington University since 1987. Virtually every adaptation and developmental process originate at the level of gene regulation by transduction of extra- or intracellular signals.
Transcription is the major target of regulation of gene expression.
Escherichia coli I . Presumably because of the amphibiotic nature of the biochemical pathway in carbon metabolism, the operon shows a multitude of controls even at the level of transcription initiation, and has been a paradigm system for studying control of transcription. The major highlight of our work in the past two years is the revelation that GalR alone exerts control on the two promoters in a multivalent way. Regulation by DNA looping. P 1 and P 2, creates a DNA loop which inhibits transcription initiation from the gal promoters.