TI - Pharmacokinetic optimization of therapy with newer antidepressants. In addition, there is a series of antidepressants with unique structures. The newer MAOIs are a significant addition to therapy, as the rapid binding action of these medications increases their safety margin with regard to tyramine interactions. Further information in this area is required. Once a therapeutic blood concentration is established, linearity is helpful in avoiding the small dose changes and repeated rechecking of concentrations of medications that would be required for those agents with nonlinear pharmacokinetics.
Sertraline stands out as having the best effects on behavior among all antidepressants.
However, fluoxetine and fluvoxamine are least likely to penetrate into breast milk. Amfebutamone has the benefits of linear pharmacokinetics with potential for defined therapeutic blood concentrations, lack of effect of liver enzymes on metabolism of the drug, and lack of significant effects of either aging or hepatic dysfunction on elimination of the drug. TI - Excretion of psychoactive drugs into breast milk. Pharmacokinetic principles and recommendations. AB - The postpartum period is a time of great physical and emotional changes.