The newest version, at the time of this writing, is 4.52. If you're using an older one, it's a good idea to upgrade, since the newer versions contain new features, as well as bugfixes. Go through the entire Configuration dialog, and set it up the way you like it. If you don't understand what an option does, consult the manual. This may take you 15 minutes, but the program will work the way you want it afterwards.
Some suggestions follow.
Since Commander's strength is in its keyboard usability, the toolbar will probably be of little use. Keep the function key buttons until you learn them and no longer need to look at the buttons to see what each one does. If you really like icons, Only standard symbols is a good choice, since you won't be slowed down by the process of retrieving the icons from each file. Use a fixed-width font for the File list font and Main window font settings. Some good choices are Courier New and Lucida Console.