The suggested dose is 400 to 800 mg twice a day. SAMe is currently sold as a dietary supplement in the United States. They concluded that the elevated homocysteine levels are directly related to symptoms of fatigue found in both FMS and CFS patients. Acupuncture may be of variable benefit with its greatest impact upon treating painful muscle. In the experience of many complementary physicians, orthomolecular therapy with the intravenous administration of up to 50 mg of vitamin C 2 to 3 times a week for 4 to 24 weeks may be helpful.
Some patients benefit from chelation therapy.
Oral or intravenous NADH has also been found to be clinically useful. Dr. Ed McDonagh also considers natural hormone replacement, DHEA, immune enhancers such as thymus and rejuvenators such as cell therapy, medications to control yeast or other bacteria if present, allergy desensitization if indicated, thyroid replacement if necessary, and Heidelburg testing if gastric dysfunction is suspected. Patients can use it for a long time without developing serious withdrawal symptoms when the drug is discontinued. The drug is virtually unknown among most physicians. Of special interest, particularly since depression compounds and confounds FMS, buprinorphine is a very rapidly acting antidepressant that works when other antidepressants fail.