Pyrantel can be used in the presence of Dirofilaria immitis . Pyrantel can be used in pregnancy, nursing, weanlings, and males used for breeding. Organophosphates The adverse effects are discussed with special reference to dichlorvos. Those of other organophosphates will be very similar. Signs typical of acetylcholinesterase inhibitors include evidence of excessive acetylcholine at muscarinic and nicotinic receptors.
Treatment is with atropine and pralidoxime.
Formulations of organophosphates are very specific for the target species , especially in flea collars and in the resins intended for oral administration. Two principle difficulties associated with dichlorvos are overcome by resins. First, they decrease the toxicity of the volatile, toxic drug. Second, they protect the drug within the vehicular reservoir from moisture to slow hydrolytic degradation. Dichlorvos is formulated in resins to make a slow release dose form.