Thrombosis is a significant concern when artificial surfaces are implanted in contact with blood.
Few quantitative studies of the coated surfaces under defined flow conditions have been published. The protein, TFPI, has a demonstrated affinity for artificial surfaces. Determine the inhibitory activity of immobilized TFPI under applied flow. Develop a computational model to simulate surface-bound TFPI inhibition of coagulation. Inhibition of this pathway by TFPI could significantly reduce the incidence of thrombotic complications in these and related processes.