MOP was the one you re probably most familiar with. The advantages of these are they are felt to have a lower incidence of fertility problems and a lower incidence of secondary leukemias. At the University of Nebraska, we re now using a regimen called Stanford 5 in which the chemotherapy is all administered weekly and it s finished in twelve weeks rather than over Non-Hodgkin s lymphoma . For treatment of low grade lymphoma, patients with localized disease will generally get radiation, perhaps with a short course of chemotherapy. There is no consensus on treatment of patients with disseminated disease.
Some people recommend observation.
These people have low grade, indolent, slow growing asymptomatic disease and sometimes we recommend a watch and wait approach. Other patients will receive single agent or combination therapy. For advanced disease, Stage II, III or IV, non-Hodgkin s lymphoma, there are any number of chemotherapy regimens that have been recommended. This is just a short list of the regimens that have been recommended. Stage I, they get a short course of chemotherapy and radiation.