In the US, I of every 4 deaths is from cancer. Since 1990, there have been approximately 5 million cancer deaths. Despite the advances made in cancer chemotherapy in recent decades, many anticancer drugs display relatively poor selectivity for cancer cells.
Solid tumors are particularly resistant to radiation and chemotherapy.
Prodrug approach has been applied to alleviate toxicity of the anticancer drugs and to improve their target specificity. The proposed compounds will be evaluated for their potential cytotoxicity against established tumor cell lines in vitro.