Tricyclic antidepresants have a tendency to worsen neuropathy so, in males, they may cause or aggravate or trigger impotence. These people may have their libido come back, but they find out that there is no erection. Occasionally, we have to discontinue these type of medications because of this side effect that is much more common in males. They work faster in the symptoms of depression. It usually takes them 4 to 5 days for the patient to start feeling better.
Side effects are different.
They do not tend to aggravate the impotence caused by neuropathy. On the other hand, they tend to increase the time between the beginning of excitement and climax. This is more of a problem with women, since most men can use a little prolongation in their role. The problem ends up then as being a very delayed or impossible orgasm in some women. There is no scientific evidence that oral agents cause or aggravate depression.