If untreated, the neonatal thrombocytopenia normally lasts 2-3 weeks, resolving spontaneously. Other entities that need to be part of the differential diagnosis include infection induced thrombocytopenia, maternal idiopathic thrombocytopenic purpura, maternal drug exposure, and other rare causes of neonatal thrombocytopenia. Neonate hemoglobin levels may be decreased secondary to bleeding. The different methods available include platelet immunofluorescence test, solid- phase red cell adherence assay, monoclonal antibody immobilization of platelet antigens. Therapeutic intervention Postnatal treatment focuses on increasing the neonate's platelet count.
Therapeutic intervention involves IVIG and platelet transfusions.
Genetic counseling as well as obstetrical high risk support for future pregnancies is strongly recommended once the diagnosis has been established. The first issue, with regards to genetic counseling is to determine the father's zygosity. If the fetus is found to be PL A1 negative, no further diagnostic testing is indicated. If the fetus is found to be PL A1 positive, cordocentesis should be considered to determine the fetal platelet count. Prenatal and perinatal management of alloimmune cytopenias.