Skunk vine is a woody vine. Its stems , climbing or prostrate, are reported to grow to 30 feet long . The leaves and stems have a skunk-like odor, especially when crushed. There is much variation in the shapes and sizes of the leaves. Leaves may be opposite on the stem or, rarely, in whorls of three.
Stipules are conspicuous.
Skunk vine flowers are smallish, light grayish pink or lilac, with red centers. The fruit are small, shiny brown orbs having 2 black seeds. University of Florida researchers are investigating Paederia foetida's role in Florida ecosystems, especially its ecophysiology and management.