Eyelid ptosis in early childhood is a harbinger of eyelid neurofibroma or plexiform neuroma. Optic nerve gliomas , neurofibromas, schwannomas, and optic nerve sheath meningiomas may involve the globe and surrounding soft tissues. Glaucoma is a rare complication. Intracranial and spinal tumors . The intracranial tumors associated with neurofibromatosis include optic gliomas, other astrocytomas, neurilemomas, acoustic neuromas, neurofibromas, and meningiomas.
Spinal tumors are usually meningiomas or neurofibromas.
These secondary tumors are most often sarcomatous, although other forms have been reported. Other neoplastic entities, such as leukemia, malignant schwannoma, Wilms' tumor, and pheochromocytoma, have also been reported in increased association with neurofibromatosis. Osseous defects and congenital dislocations . These lesions all relate to neurofibromas near or within the affected bone. Oral Pathology .