MAO inhibitors and beta-adrenergic blockers potentiate the sympathomimetic effect of pseudoephedrine. Adverse reactions may include gastrointestinal upset and nausea. Individuals may display ephedrine-like reactions such as tachycardia, palpitations, headache, dizziness or nausea. Sympathomimetic drugs have been associated with reactions such as, confusion, fear, anxiety, tenseness, restlessness, tremor, weakness, pallor, respiratory difficulty, dysuria, insomnia, hallucinations, convulsions, CNS stimulation, arrhythmias and cardiovascular collapse with hypotension. Children and the elderly may be more susceptible to systemic effects of the drug than are adults.
Treatment is symptomatic and directed towards supporting the various bodily systems.
Gastric lavage should be performed at the discretion of the attending physician. Assisted respiration may be required. Acidify the urine to enhance elimination and institute general supportive measures. If CNS stimulation is prominent, an anticonvulsant may be administered. Heart signs and electrolytes should be monitored.