Activation of several of the coagulation proteins occurs on the platelet surface. Gammaglobulin Danazol Platelet transfusions are indicated for life threatening and serious hemorrhagic episodes. Thrombotic Thrombocytopenic Purpura A fulminating, often lethal disorder. Characteristic features include thrombocytopenia, hemolytic anemia, fever, renal failure, fluctuating neurologic manifestations. Widspread hyaline occlusions in small vessels.
Therapy includes plasmapheresis, plasma transfusions, steroids.
The bleeding time is usually prolonged. Clinical features highly variable and consist of mucocutaneous bleeding manifestations. May be acquired or congenital. Acquired disorders of platelet function are more common than inherited varieties. In response to platelet stimulation with ADP, thrombin and collagen, no aggregation is noted.