A history of sensitivity to iodine per se or to other contrast agents is not an absolute contraindication to the use of iodipamide, but calls for extreme caution in administration. In the presence of severe liver damage, the contrast agent is excreted by the kidneys. If liver function is severely impaired, adequate renal function must be ascertained before injecting this contrast material. Because of the increased risk of hepatic and renal damage, the examination should not be repeated for at least 24 hours. Swollen eyelids, laryngospasm, respiratory difficulties, hypotension, cardiac reactions and cyanosis have been reported.
Severe reactions are a possibility.
Such reactions, which may require emergency measures, may take the form of a cardiovascular reaction characterized by peripheral vasodilatation with resultant hypotension and reflex tachycardia, dyspnea, agitation and confusion and cyanosis progressing to unconsciousness. Ventricular fibrillation or cardiac arrest may also occur. Renal function tests may be altered, and temporary renal shutdown may occur. Hepatotoxicity has also been reported. For best results, the usual preliminary measures for cholecystography are recommended, particularly in cholecystectomized patients, i.e., a low residue diet on the day before examination and administration of castor oil the night before or neostigmine at the time of examination to dispel intestinal gas, unless contraindicated.