Summary The ability of the rodent brain to support plasticity-related phenomena declines with increasing age. A decreased coordination of genes implicated in brain plasticity may be one factor contributing to this decline.
Synaptic rearrangement occurs after seizure activity is regarded as a model of brain plasticity.
In addition, at the peak induction the TPA transcripts were restricted to certain cortical layers of the older rats. Aberrant immunolabeling of MAP1B occurred in cortical layer VI of the aged rats where, unlike in young rats, there was heavy staining of neuronal somata.