Interferes with RNA and protein synthesis and metabolism. Disrupts fungal cell-wall membrane permeability, causing fungal cell death. Contraindications Documented hypersensitivity Interactions None reported Pregnancy C - Safety for use during pregnancy has not been established. Pregnancy C - Safety for use during pregnancy has not been established. The first oral allylamine antimycotic agent to be released, having a different mode of action than the azoles, considered to be fungicidal, rather than fungistatic.
Terbinafine inhibits the enzyme squalene epoxidase in the sterol synthesis pathway.
These doses are for onychomycosis. No definite contraindications have been established. No significant drug interactions have been identified. Pregnancy C - Safety for use during pregnancy has not been established. Corticosteroids - Treat noninfectious causes of onycholysis.