It will build up in your urine and will stay in your bladder too long. Some doctors recommend emptying your bladder in the middle of the night at least once, even if it means setting an alarm clock to do so. If you accidentally take too much, contact your doctor right away to receive an antidote. Do not drink alcohol while taking this drug, because it can make any liver problems worse. Contact your doctor before you take any other medicines, especially antibiotics.
Some antibiotics can make methotrexate much more toxic.
Tips for taking these medications Taking your medication incorrectly can result in serious side effects. Find out all you can about the medicine you're taking, its risks and its benefits. Talk to your doctor about the drug and read the package insert that comes with the drug. If you accidentally take too much, contact your doctor at once. If you vomit shortly after taking a dose or miss a dose for other reasons, check with your doctor to find out when to take another dose.