Combination of interstitial, intracavitary, and external-beam radiation therapy. Rarely, surgery may be combined with the above. Boronow RC, Hickman BT, Reagan MT, et al. Results, complications, and dosimetric and surgical considerations. Squamous cell carcinoma Patients should be considered candidates for one of the ongoing clinical trials to improve therapeutic results.
Standard treatment is inadequate.
Adenocarcinoma Patients should be considered candidates for one of the ongoing clinical trials to improve therapeutic results. In a large series only five of fifty patients with recurrence were salvaged by surgery or radiation therapy. All five of these salvaged patients originally presented with stage I or II disease and failed in the central pelvis. In centrally recurrent vaginal cancers, some patients may be candidates for pelvic exenteration or irradiation. Clinical trials are also appropriate and should be considered.