These cytokines and other factors that are present in disease process may induce or suppress, pro, anti-coagulant and fibrinolytic protein factors. The disruption of balance between these factors leads to thrombotic and hemorrhagic complications.
Tissue factor is the principal physiological initiator of the coagulation cascade.
Tissue factor gene is not normally expressed in vascular cells that come in contact with blood. Many stimuli that are elaborated in inflammation and cancer induce tissue factor expression in these cells. My research focusses upon investigating the promotion or suppression of tissue factor, tissue factor pathway inhibitor and fibrinolytic proteins gene expression in various cell types in response to cytokines and other inflammatory stimuli. Current Projects Cell specific expression of coagulant, anticoagulant and fibrinolytic proteins in response to cytokines and inflammatory stimuli with a particular emphasis on their role in lung injury. Pendurthi, U.R., Williams, J.T. and Rao, L.V.M. Inhibition of tissue factor gene activation in cultured endothelial cells by curcumin.