Talk to your doctor about it if you have bone or joint pains. Also, consider gout which produces very acute arthritis involving only one joint. Hope this helps. These are molecules that arise from DNA and RNA released by cells when they die. Patients with MPD turnover a lot of bone marrow cells when they are in a proliferative phase and, thus, produce a lot of uric acid.
Uric acid is cleared from the blood by the kidney.
When levels of uric acid are high in the plasma there may be crystallization of uric acid in the joints. This is what produces gout. When a lot of uric acid has to be cleared by the kidney uric acid may crystallize in the kidney tubules, causing kidney stones or sludge that may damage the kidney. In patients who have a lot of uric acid production it is advisable to interrupt uric acid metabolism at the step before it is produced from a precursor called hypoxanthine. This is a more soluble molecule that does not precipitate in joints or kidneys and is cleared more readily by the kidney.