Current U.S. sponsors Western Chemical Co., Argent Chemical Laboratories, and Natchez Animal Supply were asked to amend their NADAs to include the control of certain fungi on the eggs of all finfish and certain external protozoa and monogenetic trematodes on all finfish. INAD holders have been invited to submit data that has been generated to extend the NADA for the control or prevention of mortalities associated with saprolegniasis on all cultured freshwater fish. Two meetings were held in July and August 1996 to discuss the development of the Phelps Dodge product. The human food and environmental safety requirements have been met. Efficacy data have been generated by the State of Iowa.
Several facilities are interested in developing efficacy data.
The compound is near approval in Canada. Efforts are underway to use the U.S.-Canada Harmonization on Aquaculture Drug Approvals to gain U.S. approval of the drug for the same use. UMSC developed efficacy and target animal safety data on its use to control or prevent mortalities associated with saprolegniasis on fish eggs and is developing pivotal efficacy and target animal safety data for its use to control or prevent mortalities associated with saprolegniasis on freshwater fish. UMSC is assessing its use to control or prevent mortalities associated with external flavobacterial infections and its use to control or prevent external parasitic infestations on cultured freshwater fish. Several researchers are determining the drug's potential to control or prevent hamburger gill disease in catfish and whirling and proliferative kidney diseases in salmonids.