The festival, at the Roxie, is in the Mission neighborhood in 16th Street between Valencia and Guerrero. This is fairly close to downtown, or to the Tenderloin or Polk Street neighborhoods.
Some major hotels have pick-up services.
There is a shuttle to Bart which takes you into San Francisco. Please note that there are not necessarily reviewed or recommended here, but this list covers a range of accomodations. Guest Houses Noe's Nest-Lovely Bed and Breakfast in a neighborhood near the Mission where the Roxie is located. Youth Hostels Hostel Intl.