Heavy use of MDMA causes a prolonged increase in body temperature and dehydration. Users have also experienced severe depression and feelings of suicide after this drug's effects subside. MDMA impacts dopamine production, which can lead to motor coordination disturbances. PMA strongly stimulates the CNS, and at higher doses can lead to convulsions, coma and death. Ketamine was developed primarily for use in veterinary medicine, though it is also used as a pain killer in humans.
Users report hallucinations and feeling disconnected from their bodies.
Short-term paralysis, though rare, has occurred with its use. As with other hallucinogens, tolerance to this drug develops rapidly.