Microphthalmia, hypertelorism or hypotelorism, coloboma, retinal dysplasia, and orbital colobomas in some cases. Cleft lip or palate. Umbilical hernia and single umbilical artery. Polydactyly of the fingers and toes, ectrodactyly, and valgus deformity. Hyperconvex narrow fingernails.
Seizures are common.
Atrial septal defect, ventricular septal defect, coarctation of the aorta, and bicuspid aortic valve. Meckel diverticulum, intestinal malrotation, and mobile cecum.