There are no side effects reported with spirulina. However, since spirulina can accumulate heavy metals from contaminated water, consuming spirulina from such areas can increase the body's load of lead, mercury, and cadmium. There are a few reports of allergic reactions to spirulina. Many doctors of natural medicine do not advocate using caffeine or caffeine-life substances to reduce weight. Ephedra , commonly known as ma huang, is a diuretic and central nervous system stimulant.
Studies show that ephedra, particularly when combined with caffeine, promotes weight loss.
However, many nutritionally oriented doctors discourage the use of ephedra as a weight loss aid because of the many side effects that can occur with its use, especially since many of the side effects are intensified when ephedra is combined with caffeine. Guaran should be avoided during pregnancy and lactation. Long-term use may cause decreased fertility, cardiovascular disease, and several forms of cancer according to epidemiological studies of caffeine use. Ephedra has a long history of safe use at the recommended amount. Anyone with high blood pressure, heart conditions, diabetes, glaucoma, and thyroid disease and those taking MAO-inhibiting antidepressants should consult with a physician before using any type of product with ephedra.