Physical dependence to a drug occurs when an individual's tissue cells get used to a certain level of intoxication. This means the body physically changes, needing the drug in regular doses to maintain its chemical balance. Psychological dependence to a drug occurs when a person needs regular doses of the drug to maintain mental and emotional stability. In either case, a drug dependent person will experience some form of withdrawal symptoms when drug use is discontinued. Physical dependence to inhalants can occur among chronic, heavy users.
Withdrawal symptoms can include chills, cramps and hallucinations.
Psychological dependence can occur with the use of any of these drugs. Freon and butane, often used in aerosol sprays, are also included in this group. Many solvents are petroleum-based. The initial effects of solvent intoxication resemble that of alcohol. Early on, users feel uninhibited and may become impulsive, violent or engage in sexually unrestricted behavior.