You might find it slightly tiring on your voice-box at first, as you are unused to speaking in that register, but it should become comfortable with a little practice. If it does not, then you are probably trying to force your pitch up too high. With the glottis firmly closed, all the air is forced over the vocal cords, producing a fully-voiced and typically male voiced sound. Then try to learn to always use that half-open position for all voiced sounds. This is simply a matter of practice.
Upward intonation places emphasis.
On the whole, women enunciate much more clearly and precisely than men. Do not 'swallow' pronouns, articles or other 'little words' at the beginning or end of sentences. Women usually start a sentence more softly. Women tend to concentrate more on thoughts and feelings, while men concentrate on objects and actions. Men generally use more 'short cuts', colloquialisms and bad language, too.