Sherman's fox squirrels primarily utilize dreys. A study on the White Oak Plantation in Florida revealed that primary or winter dreys were built of mostly longleaf needles and generally located high in longleaf pines. The secondary, or summer, dreys were generally built of twigs and leafs and found in hardwood trees. Both dreys are waterproof, but the winter drey is always more elaborate than the summer drey. The Sherman's fox squirrel has a life span of seven to eight years.
Some females produce a litter each breeding season but one litter per year is more common.
The normal litter contains two to four young. The young strike out on their own at about eight months. Some may travel five miles or more before establishing a home range. These squirrels have a large home range. Home ranges for males average 200 acres and females average around 80 acres.