Intolerance to contact lenses may develop. Conjunctivitis, optic neuritis, corneal opacities, dry eyes, decrease in acuity of night vision, photophobia, eyelid inflammation, cataracts, visual disturbances. Flushing, palpitation, tachycardia. White cells in urine, proteinuria, nonspecific urogenital findings, microscopic or gross hematuria, abnormal menses. HDL, RBC parameters, WBC counts.
Symptoms are transient.
Symptoms are quickly resolved with drug cessation or decrease in dose. If necessary, a second course of therapy may be instituted after a rest period of 2 months. Prevent second tumors in squamous-cell carcinoma of the head and neck.