In most cases, the infection is not severe and can be treated with painkilling drugs and a topical antibiotic to prevent secondary bacterial infection. Even after the blisters resolve, there may be some persistent weakness for a few days or weeks. Oral acyclovir and famciclovir antiviral drugs are an effective form of treatment when used in the first 48 to 72 hours after infection. Painkilling medications are often required during the acute phase. Post-hepatic neuralgia is a condition that is characterized by continued shooting pain along the path of the nerves, which can occur after the acute attack of shingles is over.
Treatment can be difficult, and the pain severe, but it usually diminishes over time.
Early treatment with acyclovir or famciclovir may reduce the incidence of post-hepatic neuralgia.