A repeat CT scan 12 days later showed progression of the lesions despite continuation of antitoxoplasmosis treatment. These findings are suggestive of CNS lymphoma. Discussion Features of CNS pathologies in AIDS AIDS continues to be one of the most important causes of morbidity and mortality, especially in the age group between 20 and 45 years. Treponema pallidum, Cytomegalovirus, Nocardia, Actinomycosis, Candida and others, metastatic lymphoma, and Kaposi s sarcoma. However none of these findings favour lymphoma or any of the opportunistic infections.
Serology is fairly sensitive, but nonspecific.
Rapid progression in short intervals also favours lymphoma. Enhancing lesions in the basal ganglia or the corticomedullary junction are more likely due to Toxoplasma gondii. In AIDS patients with primary CNS lymphoma this approach has a significantly negative impact on morbidity and duration of survival, as these patients have only an average survival time of 4 months with radiation therapy. and 1.5 months without radiation therapy. A fast and accurate differentiation between lymphoma and infectious causes is of vital importance for this patient group. Malley et al.