In these instances, a narrowly focused CTL response selects for escape variants in a manner similar to single-agent antiretroviral therapy. It is premature to draw generalized conclusions from these studies regarding the exact role CTLs play in maintaining the asymptomatic state or which responses may be the most beneficial. With mounting evidence that the HIV-specific CTL response plays some role in limiting viral replication, and that the response is vigorous enough to exert selective pressure, it seems reasonable to assume that having a broadly directed response in place early in infection would lead to a longer asymptomatic period. These findings also stress the importance of developing vaccines designed to stimulate virus-specific CTL responses. Walker BD, Chakrabarti S, Moss B, et al.
T lymphocytes in seropositive individuals.
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