Main Outcome Measure Occurrence of major congenital malformations. However, exposed women who had a previous miscarriage had rates of major malformation that were similar to exposed women who had no previous miscarriage. Conclusions Occupational exposure to organic solvents during pregnancy is associated with an increased risk of major fetal malformations. This risk appears to be increased among women who report symptoms associated with organic solvent exposure. Women's exposure to organic solvents should be minimized during pregnancy.
Symptomatic exposure appears to predict higher fetal risk for malformations.
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