And only finally, and later, is the production of a definitive fibrin clot. We ve simplified this so that we only have the relevant factors sitting around there. There are no white cells or red cells or anything like that. But what you have here is the circulation of platelets in a discoid configuration, some fibrinogen and von Willebrand gram factor. Well, let s start putting this to work.
Vascular disorders leading to bleeding are unusual.
Two are listed here, Ehlers-Danlos, which is the disorder of collagen, and scurvy which is vitamin C deficiency. Chances are you won t see this too often in your pediatric practice. But you will see problems in the formation of the platelet plug. As I mentioned, the carboxyl residues form one side of the sandwich. The von Willebrand factor is the meat, and the platelets are the other piece of bread.