I can access and edit my store from anywhere on the Internet. The Store Manager is loaded with all kinds of easy to use tools, from Excel spreadsheet exports to email forwarding to charts of my hits and sales. But that's not even the good part. Picture, description, price and all. No banner ads, no email campaigns, no search engine positioning.
Smaller stores are better.
Focus on a single product line, sell name brands, market to a niche. Your keywords will work better that way too, if they all relate to the same product line. However, it's nice if you can make money right off the bat while you wait for your site to rise in the rankings. They don't even know I exist. I'm telling you this because it works for us, and I believe it will for you, too.