Juvenile Xanthogranuloma is a benign cutaneous histiocytic proliferation initially described by Adamson in 1905. Clinically, the lesions are typically small. A recent series of 34 cases showed a bimodal age distribution, with one peak occuring at less than one year's age, and another peak in the 3rd decade. The overlying epidermis is typically flattened.
Ulceration is rare.
Lymphocytic epidermotrophism is a frequent finding. One series of nine juvenile xanthogranulomas examined the lesions for immunohistochemical staining patterns. Staining for S100 and CDla, on the other hand, was negative in all cases. They are benign and usually involute gradually. It is crucial to distinguish juvenile xanthogranulomas from the X-histiocytoses.