Be certain the floor is not weak anywhere. Find and remove any sharp points or hooks which may cut or hang the llamas. Do not have anything protruding into areas where animals will be standing or laying. Make sure all sides are solid so that no legs will get caught in holes or slats. Secure all items stored in the vehicle so they will not shift into areas where the animals are riding.
Temperature is always the first thing to consider when transporting llamas.
High temperatures are a serious concern with llamas. Riding in a trailer with little air circulation over hot pavement with a wool coat one can be deadly as well as uncomfortable. Temperatures of 80 to 85 degrees or less can become a problem. Increased humidity will cause difficulty with the heat at much lower temperatures than would be expected otherwise. Travel during the night or the early morning hours and avoid traveling during mid-day and afternoon.