HPS is characterized by a flu-like febrile illness that rapidly progresses to shock and adult respiratory distress syndrome with thrombocytopenia, hemoconcentration, and leukocytosis. Treatment is supportive as discussed below. Ventilation may be necessary within 24 hours of onset. Incubation in South American HFs ranges from 7-14 days. South American HFs are characterized by the gradual onset of fever, myalgia, and signs and symptoms as described above under general signs and symptoms.
Treatment is supportive and also includes ribavirin as discussed below.
Incubation of Lassa fever ranges from 7-21 days. Presentation of Lassa fever varies. Common early symptoms are gradual onset of fever, malaise, headache, and abdominal pain. Other symptoms are conjunctivitis, facial swelling, sore throat, non-productive cough, retrosternal pain, nausea, vomiting, diarrhea, back pain, and myalgia. Respiratory rate, temperature, pulse rate are increased and blood pressure decreased.