Also if the city is really organized, the address will tell you exactly where to go. For example, here in Minneapolis, a building at 350 4th Avenue is on 4th Avenue, halfway between 3rd and 4th streets. Of course there are places where it gets completely mixed up. There is a spot in Minneapolis where you can stand at the corner of Washington Avenue and Washington Avenue and give directions to Washington Avenue which is one block over. Because the streets replaced the cow paths.
Some streets can be miles long with signs only at the very beginning and the very end.
This is the names of the closest intersecting roads. For example Washington Street and 44th Street. If you're in the US long enough to buy your own car, you will have the option of getting car insurance that covers rentals. Check with your credit card company about this, as hell will freeze over before car rental companies disclose this kind of information. The benefit of buying the insurance when renting a vehicle is that generally it covers everything.