Histologically, the lesions present as branching, finger-like, papillary connective tissue stroma covered by thickened, hyperplastic epithelium, which may show excessive surface keratinization. Koilocytes may be noted in the superficial zone of the epithelium. Cellular atypia is absent. This occurs in secondary syphilis and develops 2 to 8 weeks after the primary chancre. It is highly infectious and presents as gray-white to erythematous, painless, broad, moist plaques.
White plaques are present on the skin of the shaft and prepuce.