Lethargic does may begin eating and become more active and alert within 12 hours. Tetany usually subsides in 30-60 minutes after treatment. Correction of the calcium imbalance is necessary. A low calcium level during late pregnancy will help to control the problem. 25 Polioencephalomalacia Also known as cerebrocortical necrosis.
Thiamine is produced in the rumen.
In PEM, thiaminase, an enzyme that destroys thiamine, is thought to be produced by certain bacteria within the rumen and thiamine deficiency develops. A thiamine - analogue is also produced within the rumen which may replace thiamine in important metabolic reactions in the brain. Necrosis of the brain occurs. Young animals on high grain diets are affected more often. Older animals and pastured animals may be occasionally involved.