I was on the pill, and it did help. However, my neurologist took me off it due to a borderline pseudotumor. If PMS is diagnosed by your physician after looking at your cycle for a few months, then medicines called SSRI, serotonin-specific reuptake inhibitors, meaning drugs such as Zoloft, Prozac and Paxil may be hepful. SSRI medication such as Prozac and Zoloft and the whole family of drugs similar to those have a lot less side effcts than the older anti-depressant medications. However, they do have the potential for side effects.
Some women notice a decrease in libido or difficulty reaching orgasm.
But in my experience most women who get relief from these medications continue with them and if they have occassional side effects, they don't seem to mind them compared to the benefits they are gaining. Prozac is mainly for psychological symptoms but some physical symptoms do get better as well. Then about 8-10 days of normalcy. This is getting worse, she has tried hypericum, seen psychologists with only minimal relief. She probably should be seen by a doctor who has experience with PMS since your wife has already seen other physicians.