4-AP dose not appear to benefit cognitive functions. We report three cases of 4-aminopyridine overdose resulting in seizure activity. All patients were on therapeutic regimens for the treatment of multiple sclerosis. All patients were responsive to intensive supportive care, although the length of toxicity was prolonged more than 24 hours in one patient. Seizure activity was responsive to benzodiazepine and phenytoin therapy.
Side effects continue to be a problem.
University referral center. Neurophysiologic variables for nonresponders, neurologic functions and symptoms on a visual analogue scale for responders, and side effects for both groups. Hospital Amsterdam The Netherlands. OK, now you have all the data that is currently available. There is some modest improvement but it is not without risk.