Here we have observed that imposed behaviour, i.e. a requirement to observe a normal day in terms of sleep, work and meal times, appears to maintain synchrony of physiological rhythms with the 24 hour day whereas reports from other bases with no such impositions show subjects uncoupled from 24 hours. On Halley we showed for the first time that light pulses of sufficient intensity will shift human circadian rhythms. Recent developments from this observation have included the use of timed light pulses to hasten adaptation to a normal day after shift work. This work has implications inter alia for large sections of the world's population in winter light conditions. The profits from this exercise support research in the section at all levels.
Shift workers complain of sleep disturbance and problems of gastro-intestinal function.
Their work has concentrated on the development of strategies for preventing loss of essential immunoglobin chromosomes using the rabbit and the sheep as experimental models and monitoring the presence of non-murine DNA in the murine genome. Recently their work has been extended to the development of chimaeric bispecific antibodies for use in homogeneous immunoassays. With Dr. J. Chakraborty, Mr. S. Frost completed a PhD on the analytical applications of liposomes in immunoassay and Mr. Graham Lawson continues investigations on the metabolism of 6-methylprednisolone in man. Co Durham under the trade name Prosep . Much of this material is currently being used, at process-scale, for the purification of antibodies destined for human therapeutic use.