There is no vehicular access to the Kalaupapa Peninsula. Most accidents that occur are slips and falls while hiking down the trail. The trail is accessed off Hwy. 470 near Palaau State Park and the Kalaupapa overlook. The park can be reached by air through commercial and charter flights from Honolulu, Oahu, from Maui, and from Hoolehua, Molokai.
Some visitors arrive by private boats.
Inc. Damien Tours, owned and operated by a Kalaupapa resident, offers the commercial tour of Kalaupapa. The administration of the Hansen's disease settlement and control of public access into the area are still under the jurisdiction of the State Department of Health. All visitors to the park must receive a permit from the Department of Health to enter the Kalaupapa settlement. The commercial tour company arranges the permit for their customers. Guests of residents have their permits arranged by their sponsor.