Introduction One of the fundamental questions in cell biology is how proteins are transported to the correct destination within the cell. Even thogh our primary goal is to understand basic cell function there is a medical background.
Transport defects within the cell constitute the molecular basis for some inherited human diseases.
As transport vehicles the cells use membrane vesicles which bud from the donor membrane and fuse with the target membrane. We are interested in the proteins which are required for recognition between transport vesicle and target membrane and for their subsequent fusion. As model systems we work with baker's yeast, mouse cell lines and tissues and plan to generate mouse knock out models. A position for a PhD. student is currently open. Applicants should have experiences in molecular biology or biochemistry.