Remissions for nodal forms of two years or more are possible. Side effects of chemotherapy found in human patients are often absent in the dog. However, evaluation of hematology parameters are important to monitor toxicity. Without therapy most lymphoma patients succumb within 2 months of the diagnosis. Therapy for extranodal lymphoma usually requires surgery, chemotherapy and, or radiation with follow up diagnostics checking for reoccurrence.
Success is dependent on the location of the extranodal lymphoma.