They observed a wide spectrum of morphologic intergrades between nevi and fibrous papule and believe this is strong circumstantial evidence of a pathogenic relationship between these entities. Several studies have shown that fibrous papule did not stain for S-100 protein. One explanation is that the lesions could represent nevi that have degenerated or changed to the point that they do not synthesize S-100 protein. Others studies found that the dermal stellate cells of the fibrous papule contain factor XIIIa, which suggests that they are of fibrohistiocytic lineage or possibly derive from dermal dendrocytes. The lesions are benign.
Treatment is usually surgical with excision or curettage.
Reassure the patient. Histopathology of fibrous papule showing focal fibrosis and vascular proliferation in the upper dermis. Report of two cases associated to psoriasis and fibrous papule of the nose. Fibrous papule of the face. Phenotypic characterisation of stellate and giant cells in giant cell fibroma by immunocytochemistry.