Seizures, cerebrovascular accidents, CNS lymphoma, and meningitis may also develop. Children may do well for several years. Behavioral changes associated with chronic disease, interaction with peers, or frequent medical visits may mimic neurologic changes. Zoster and varicella infections can be severe. Eye manifestions include frequent conjunctivitis and blepharitis.
Severe retinopathies are uncommon.
ENT manifestations include chronic otitis media and sinusitis. Eradication of these infections may be difficult. These children are at risk of developing mastoiditis. Tonsillar and adenoidal hypertrophy may result along with generalized lymphatic hypertrophy. Oral infections include thrush, periodontitis, severe dental caries, parotitis, and cervical lymphadenopathy.