TOR signalling and control of cell growth. TOR2 is part of two related signaling pathways coordinating cell growth in Saccharomyces cerevisiae . Cell wall integrity modulates RHO1 activity via the exchange factor ROM2. The RHO1 effector PKC1, but not BNI1, mediates signalling from TOR2 to the actin cytoskeleton. The TOR nutrient-signalling pathway phosphorylates NPR1 and inhibits turnover of the tryptophan permease.
Starvation induces vacuolar targeting and degradation of the tryptophan permease in yeast.
J. Cell Biol. Cell wall stress depolarizes cell growth via hyperactivation of RHO1. J. Cell Biol. The TOR signalling pathway controls nuclear localization of nutrient-regulated transcription factors. Analysis of deletion phenotypes and GFP fusions of 21 novel Saccharomyces cerevisiae open reading frames.