We are working with Dr. Pamela Kling, M.D., University of Arizona Medical Center, examining the effects of iron loading via erythrocyte transfusions on the levels of these proteins in the plasma and blood cells of premature infants. A second area of clinical reseach we have initiated is the study of the effects of iron particulates, free radicals and related compounds in air pollution and cigarette smoke on oxidative damage of human lung cells. We are in the process of evaluating Manduca sexta as a potential biological model that will allow us to conduct whole animal studies to evaluate the effects of iron overload on iron metabolism. We also are studying the adaption of Aedes aegypti to iron loading provided during blood feeding. Increased knowledge of iron metabolism in blood- feeding insects that act as disease vectors could suggest new strategies for vector or infectious agent control.
Transcriptional control is relevant in the modulation of mosquito ferritin synthesis by iron.
Dianzhang Zhang, George Dimopoulos, Anna W. Smith, Fotis C. Kafatos and Joy J. Winzerling. Molecular Characterization of Two Mosquito IRP1 Genes. Manuscript in Preparation. Currently in Revision. Currently in revision.