A congenital heart defect in which the position of the two major vessels that carry blood away from the heart, the aorta and the pulmonary artery, is transposed. Prenatal factors that are associated with a higher than normal incidence of the disease include maternal rubella or other viral illnesses during pregnancy , poor prenatal nutrition, maternal alcoholism , maternal age over 40, and diabetes . In transposition of the great vessels, there is no communication between the pulmonary circulation and the systemic circulation. There is usually an associated defect that permits the mixing of the systemic and pulmonary circulation to provide some oxygenated blood to the body. Without such a defect, the condition is fatal.
Symptoms appear at birth or very soon afterwards.
The severity of the symptoms depends upon the type of associated defect and the resulting amount of oxygenated blood supplied to the general circulation. The condition affects approximately 40 out of 100,000 infants. The information provided herein should not be used for diagnosis or treatment of any medical condition. A licensed physician should be consulted for diagnosis and treatment of any and all medical conditions. Inc. Any duplication or distribution of the information contained herein is strictly prohibited.