Its action is enhanced by the detergent effect of bile. In April 1999, the FDA approved orlistat as a treatment for obesity. Orlistat inactivates pancreatic lipase. About one-third of ingested fats fails to be broken down into absorbable fatty acids and monoglycerides and simply passes out in the feces. These are immediately converted into the proteolytic enzymes trypsin and chymotrypsin.
Trypsin cleaves peptide bonds on the C-terminal side of arginines and lysines .
This enzyme removes, one by one, the amino acids at the C-terminal of peptides. The small intestine Digestion within the small intestine produces a mixture of disaccharides, peptides, fatty acids, and monoglycerides. The final digestion and absorption of these substances occurs in the villi . Several aminopeptidases are incorporated in the plasma membrane of the cells of the villi. Fructose simply diffuses into the villi, but both glucose and galactose are absorbed by active transport .