T H T is the heterozygosity with HWE using average allele freqs pbar and qbar across subpops. For each locus, p i is the freq of the allele that is homozygous. F ST is the fixation index among subpopulations in the larger whole, typically a major racial group. Right side of eqn is per locus genotype freq taking FST into account. This assumes no natural selection takes place.
Selection can alter allele freqs.
I is the freq of heterozygous genotypes in an inbred subpop F or the inbreeding coefficient . The above eqns allow comparisons between genotype freqs in inbred vs random mating subpopulations.