During the 1920's plans to construct the railroad into North Carolina were abandoned when existing lines were purchased by the railroad. Most of the NRT is very isolated - so use caution and do not exceed your skills. The local government agencies support and provide excellent emergency services - don't risk their lives by risking yours. Horses with and without riders and hikers are common. Use caution when approaching and overtaking horses.
Wildlife is plentiful and protected.
Limited access is provided to safe water - carry your own or filter. Poisonous plants border the trail in several locations. The locals take trespassing serious - ask before camping. Summers in the New River Valley are hot and humid. Sudden releases of water can occur from the dams.