Dr. Shay's expertise lies in understanding how the availability of nutrients affects gene expression and metabolism. Research in Dr. Shay's lab has been focused on understanding changes in metabolism that accompany such deficiencies. For example, the hypothalamus has long been recognized to be an important part of the appetite regulation system. The action of specific neuropeptides, including neuropeptide Y, galanin, orexin, and leptin are an important part of this system. Dr. Shay has been studying the expression, processing, and secretion of these peptides during the anorexia caused by zinc deficiency.
Zinc deficiency reduces the production of leptin, an important signaling molecule.
Reduced leptin levels during zinc deficiency may be a part of reproductive problems associated with this nutrient deficiency. Studies have focused on non-protein components of these food sources, such as isoflavones. Other research has shown that the amino acid composition of dietary protein may influence lipid metabolism in the body. Projects have been undertaken to determine which component or property of soy protein is more important as a factor affecting blood lipid levels. His lab typically includes graduate, post-doctoral, and undergraduate students.