However, because the production of Autoimmune Antibody is independent of the Pituitary gland the -ve feedback system has no effect. Antibody will continue to be produced, and Thyroid hormones will be continually released, causing physiological damage. Some types of HLA, if present, increase the likelihood of the disease appearing. Gender Female susceptibility is 3 times greater than for males, hinting at a hormonal link. Especially the 'Group A' Streptococci, which seem to cause Rheumatic heart disease.
Viruses Especially Reteroviruses.
L-Dopa is implicated in Systemic Lupus Erythematosus , and also Good Pasteurs syndrome .