If you have no network, you loose that. If you are homebound, again, your F2F network is limited. Online can provide connections. I would say that there are people for whom online life is a poor substitute for offline life. Timid, adolescent, tempted to spend more time online where you have more control of relationships.
Some people use it pathologically, but way too much has been made of that.
Circumstances exist where people do get together offline and form f2f relationships, especially when they are geographically proximate. Look at how people have used online tools to advocate, organize, and recruit. Liverpool used to be the major port for England. Dock authorities offered a buyout package to close the port for commercial traffic. The dock workers went on strike, and used the web to mobilize other dock workers worldwide.