Therefore, the difference in the incidence of infection may reflect the extent of impregnation on the catheters, in addition to the difference in active ingredients. These studies suggest the potential for resistance against the antimicrobial agents used to impregnate these catheters as their clinical use becomes more widespread. A formal cost-benefit analysis has not been published. However, use of this device led to fourfold reduction in the incidence of infections, and the device would most likely be cost-effective when used with central venous catheters in place for approximately 2 weeks. However, the currently marketed device has been modified, and entry of iodine into the bloodstream with daily use has not been reported.
Several strategies reduce the risk for catheter-related bloodstream infection.
Some of the nontechnologic interventions aimed at reducing the risk for catheter-related bloodstream infection, such as quality improvement programs, depend on changes in human behavior. Once implemented, whether they remain effective over the long term remains to be seen. Future Strategies Greater understanding of the pathogenesis of intravascular-related infections will help prevent such infections. He was chief medical resident at St. Louis University Hospitals and infectious disease fellow at the University of Wisconsin Hospitals. Richet H, Hubert B, Nitemberg G, Andremont A, Buu-Hoi A, Ourbak P, et al.