If you have a chronic infection, it must be treated because as time goes on and the disease progresses, your immune system has less capacity to fight-off the illness. People that have mycoplasma infection can be treated with suitable antibiotics. The therapy can take over one year. The illness starts off as a pneumonia-like illness or lung infection that just won't go away. Often described as a flu-like illness.
Symptoms can wax and wane.
It is believed that the host is responding to an infectious agent. The mycoplasma carries some of the antigens and host antigens with it. Mostly they are inside cells but when they leave the cell it carries some antigens with it and then the host can respond against it. When it does that some of the cells respond against the host cells resulting in chronic neurologic problems where the antibodies or autoimmune system destroys nervous tissue. Classic PCR cannot detect the bacteria.