The lesions start as erythematous macules which quickly transform into pustules, and usually involve exposed skin such as the hands and face. The characterisic feature is accumulation of neutrophils under the stratum corneum, often forming a subcorneal pustule. The presence of bacteria in these areas can be demonstrated with special stains.
Transmission involves direct contact or autoinoculation.
They may spontaneously regress within 6 months to 2 years, although various therapies are available. Gross These lesions can occur anywhere, but are most frequently found on the hands. They appear as gray-white to tan, fat to convex papules with a rough surface. EM reveals numerous intranuclear viral particles. The most common therapies are salicylic acid preparations and liquid nitrogen.