Dr. McNamara's primary interest is in pharmacokinetic and pharmacodynamic research with a particular emphasis on drug transport.
Transporters play a pivotal role in the movement of drugs across biological membranes.
As such, these proteins can dominate the tissue specific distribution of drugs altering their cellular pharmacokinetics. Transporters may also govern the systemic clearance and bioavailability of drugs. Hence, membrane transporters can control drug efficacy and toxicity. The research utilizes current technology including cell culture, molecular biology, whole animal and clinical studies studies, microdialysis, high performance liquid chromatography, computer model fitting and simulations. Active transport of cimetidine into human milk.