Ulcerative colitis almost always begins in the rectum and extends up the colon for a variable distance. Ulcerative colitis has been reported in infants, but these reports may have been actually misdiagnosed milk protein intolerance. Bloody diarrhea with mucus is the most typical first symptom of ulcerative colitis. The generalized or systemic signs of anorexia, weight loss, and growth failure may be present, these are more typical of Crohn disease.
Ulcerative colitis is characterized by unpredictable flareups.
It usually may be quieted with medications, but eventually it recurs. Occasionally, the colitis becomes intractable and may then require surgical treatment. Treatment is aimed at controlling symptoms and reducing the risk of recurrence. It has been used extensively over many years, and its effects and side effects are well known. It is the only drug known to prevent relapses.