The factors associated with insulin resistance discussed here are obesity, inactivity and diet. NF-alpha is produced in proportion to the amount of fat a person has, and excessive amounts can be produced from adipocytes. TNF-alpha cannot, however account for hepatic insulin resistance. Regular physical activity is thought to help manage and protect against insulin resistance. Likewise, epidemiological studies suggest that inactivity and a sedentary lifestyle promote insulin resistance.
Vigorous exercise increases glucose transport to skeletal muscles and increases glycogen synthesis.
The effect can last up to 48 hours after acute exercise, says Dr. Marleen van Baak of Maastricht University, in the Netherlands. The Role of Diet Dietary contributors to Insulin Resistance Diet can profoundly influence the extent to which insulin resistance is manifested. There is increasing evidence that diet has an important role in the development of insulin resistance. Despite this, the relative importance of fat and carbohydrate in the expression of reduced insulin sensitivity remains controversial. Complex carbohydrates especially those with a low glycemic index may have a beneficial effect on insulin action, although there is no evidence for a direct effect, says Dr. Len Storlien of the University of Wollongong, in Australia.