Although glassy cell carcinomas may have focal squamous or adenocarcinmatous differentiation, a prominent component is not usually seen. Although these tumors may show a plasmacytic and eosinophilic infiltrate, the glassy cell carcinoma often has an extensive eosinophilic infiltrate which is characteristic. Alveolar soft part sarcoma is a well circumscribed tumor with an alveolar pattern and PAS positive crystals within the cytoplasm. The clinical course is that of an aggressive tumor with a tendency to metastasize early. Patients who present with smaller, exophytic masses tend to be diagnosed earlier, and when treated aggressively, fare better than those patients who present with endophytic tumors.
Treatment is aggressive with radical hysterectomy and adjuvant irradiation.
The biologic behavior of glassy cell carcinoma is similar to the other poorly differentiated carcinomas mentioned above, but it distinguishes itself by affecting younger patients, making early recognition extremely important. Glassy cell carcinomas have also been reported in the endometrium and colon. Glassy cell carcinoma of the colon with human chorionic gonadotropin production. A case report with immunohistochemical and ultrastructural analysis. American Journal of Surgical Pathology.