Used to treat bi-polar depression 2. Exposure during the first trimester presents an increase in risk for fetal heart malformations, particularly Ebstein's anomaly. Alterations in cognition or behavior have not been noted in prenatally exposed children. Use around time of delivery may result in lithium toxicity in the neonate including neurological, cardiac, and hepatic dysfunction, goiter. Secreted in breastmilk in significant amounts.
Symptomatic manifestations are much less frequent in infants of women with recurrent infections.
G. Cocaine 1. Obstetrical complications such as pregnancy loss, IUGR, premature delivery, abruption. Anomalies of the genitourinary system, cardiac malformations, brain infarcts, and necrotizing enterocolitis have also been reported in exposed fetuses. Maternal use in the third trimester has been associated with problems in the newborn period such as jitteriness, abnormalities in muscle tone, difficulty feeding, and impaired maternal-infant bonding. Cocaine is excreted in breastmilk in relatively large amounts, and cocaine toxicity has been reported in infants exposed via nursing.