IgE - monomer, binds to mast cells and basophils, provoking histamine release. Attenuated whole-agent vaccines are made from living, mutated, weakened microbes. MMR, Sabin polio, old Pertussis. Inactivated whole-agent vaccines are made from killed microbes. Salk polio, rabies 3.
Subunit vaccines contain only the antigenic fragment of the microbe.
Hepatitis B, new Pertussis 4. Conjugated vaccines have the above subunit attached to proteins to stimulate better response, especially in infants. Haemophilus influenza B 5. Nucleic-acid vaccines contain naked DNA, which stimulates response.