J Biomech Eng. Christian P. Larsen, M.D., Department of Surgery, Emory University Analysis of a single-center experience with mycophenolate mofetil based immunosuppression in renal transplantation. Analysis of expression and function of the costimulatory molecule 4-1BB in alloimmune responses. Transplantation of the bone marrow microenvironment leads to hematopoietic chimerism without cytoreductive conditioning. Vigorous allograft rejection in the absence of danger.
T cells play a critical role in costimulation blockade-resistant allograft rejection.
J Clin Invest. 4-1BB ligand, a member of the TNF family, is important for the generation of antiviral CD8 T cell responses. CD40-CD40 ligand costimulation is required for generating antiviral CD4 T cell responses but is dispensable for CD8 T cell responses. Whitmire JK, Flavell RA, Grewal IS, Larsen CP, Pearson TC, Ahmed R. J Immunol. Robert M. Nerem, Ph.D. Parker H. Petit Institute for Bioengineering and Bioscience and School of Mechanical Engineering, Georgia Institute of Technology Dynamic mechanical conditioning of collagen-gel blood vessel constructs induces remodeling in vitro.