The Galiuro Wilderness lies in the western portion of the Safford Ranger District in southeastern Arizona. The Galiuro Mountains are a very rough and brushy sample of the block-like uplifts rising abruptly from relatively level plains that are characteristic of southern Arizona. Natural geological erosion has produced many rugged cliffs and steep slopes which have brightly colored exposed soils and rocks. The mountain is a double range bisected by two main canyons, Rattlesnake and Redfield. The wilderness boundary generally follows the forest boundary on the west and approximately 1 mile east of Trail 287 on the east.
Vegetation ranges from semi-desert grassland to mixed conifer.
Riparian areas are found in canyons throughout the wilderness. There are few dependable water sources. Outstanding opportunities exist for solitude, viewing mountain scenery and primitive outdoor recreation. The majority of the wilderness is steep rocky and brushy. Because of the rugged terrain, travel by foot and horseback is limited.