Some users can also develop hypertension.
Some studies have also observed a decreased incidence of colon cancer among women taking supplemental hormones. According to the American Cancer Society, estrogen replacement for only a year resulted in less deaths from colon cancer, the third leading cause of cancer deaths among women. While the women on placebo gained an average of 4.6 lbs., the women taking estrogen alone gained 1.5 lbs. The women taking estrogen along with a progestin, either cyclically to approximate a natural cycle or continuously also gained weight- 2.9 lbs. with cyclical medroxyprogesterone acetate and 2.0 lbs. Those assigned to micronized progesterone gained 2.9 lbs.