The drug is also contraindicated in severe renal insufficiency and in patients with an active peptic ulcer. Fluotic is not intended for dental use. Mild reactions consisting of gastrointestinal complaints, musculoskeletal pain and skin rash may occur. Initial symptoms are secondary to the local action of sodium fluoride on the mucosa of the gastrointestinal tract. Salivation, nausea, abdominal pain, vomiting, and diarrhea are frequent.
Systemic symptoms are varied and severe.
The patient shows signs of increasing irritability of the nervous system, including paresthesias, a positive Chvostek sign, hyperactive reflexes, and tonic and clonic convulsions. These signs are related to the calcium binding effect of sodium fluoride. Hypocalcemia and hypoglycemia are frequent laboratory findings. The signs may be delayed for several hours. Pain in various muscle groups may occur.