Going to a conference is a big deal. Continuing education can be hard to arrange as well, although with online courses becoming more popular, that is easing some. Another negative is compensation. Currently, I am not paid as well as my cohorts in the United States are. Some of this differential is because of the current dollar to French franc exchange rate.
Salaries vary greatly from school to school.
In my experience, this is based not on the cost of living in these areas but on the availability of teachers. However, as I've done this for 20 years, I obviously feel that the positive outweighs the negative. The school population is really exciting. Many students are true global nomad. They've lived all across the world.