Drink plenty of fluids. Avoid tight clothing. Do not sit with your legs crossed at the knees. This will return to normal when you stop taking medroxyprogesterone. You may gain or lose weight due to a change in appetite.
Weight gain is more common.
Your appetite will return to normal when you stop taking medroxyprogesterone. Sugar control may be affected in diabetics. Check your blood sugar regularly if you are diabetic. Your skin may darken in some areas. This will slowly return to normal once you stop treatment with medroxyprogesterone.