Students solve problems to apply these relationships to real systems to show their relevance and utility. This course provides background necessary for the design of experiments, the interpretation of results, and the promulgation of new theory regarding pharmaceutical systems that involve liquids. A survey of the performance and processing of solid dosage forms. As most pharmaceuticals are prepared from powders, emphasis is on identifying, measuring, and controlling those properties that decide the processing characteristics of powdered materials. Recent explosion in biotechnology has led to emergence of novel molecules, including proteins, peptides, and antisense compounds.
Students make an oral presentation on a preselected topic agreed upon by the instructor.
Topics include medicinal chemistry, pharmaceutics, pharmacology and toxicology, and pharmacokinetics. A computer laboratory is associated with molecular modeling aspect. A detailed study of the principles of drug transport, distribution, biotransformation, binding and excretion, with emphasis on quantitative aspects and measurement of these processes. Topics include targets of biologically active molecules, approaches to studying ligand and target interactions, overview of drug discovery, agents acting on specific targets, combinatorial chemistry, computation chemistry, and structure-activity relationships. It is a logical extension of PHAR 701 with a primary focus on disperse heterogeneous systems.