The incidence was 0.52 in never users, 0.51 in former users and 2.1 in current users. Therefore, ERT decreased cardiovascular mortality but not morbidity. ERT did not increase the risk of breast cancer, although the risk of endometrial cancer was increased. It is important to note that this study only investigated unopposed estrogen use. Raiha I, et al.
Warfarin has a narrow therapeutic range.
An inadequate anticoagulant effect is associated with decreased efficacy, and an excessive anticoagulant effect may lead to increased bleeding. In order to achieve the anticoagulant effect quickly but safely, various warfarin loading doses have been suggested. A study was conducted to prospectively evaluate the efficacy of 5 mg vs. 10 mg warfarin loading doses in achieving a therapeutic INR for two consecutive days. Patients were randomized to receive an initial 5 mg warfarin dose or 10 mg warfarin dose on days 1 and 2 of the study. Warfarin dose adjustments were made on subsequent days based on dosing algorithms.