Fever tends to wax and wane in 48-72 hour cycles, though cycles may be irregular, especially with infection by P. falciporum . Onset may also be insidious, with less dramatic symptoms such as fever, headache, dyspnea, abdominal pain, nausea, diarrhea, myalgias, and splenomegaly. P. falciporum may cause parasitemia resulting in a life-threatening condition characterized by hemolysis, jaundice, anemia, acute renal failure, and hemoglobinuria. Cerebral malaria, also life-threatening, is characterized by gradual onset of severe headache, drowsiness, delerium, and coma. Seizures may also occur and are most common in children.
Treatment depends on the organism, immune status of the patient, and severity of the attack.
Oral chloroquine is a mainstay of treatment except for infection with chloroquine-resistant P. falciporum . Combination drug treatment is common, e.g., mefloquine combined with artesunate for multidrug-resistant strains as described in the full discussion. Acute septicemic melioidosis is most common among debilitated persons. Chronic suppurative disease may involve virtually any body system. Recrudescence may occur many years after the initial infection.