Currently, the focus is on finding out how estrogen up-regulates the expression of estrogen receptor gene. The work is supported by National Science Foundation and USDA grants. J. Steroid Biochem. Oestradiol up-regulates oestrogen receptor and cyclophilin mRNA concentrations in endometrium, but has opposite effects in liver. J. Steroid Biochem.
Tamoxifen acts as an oestrogen agonist in endometrium of the ewe.
Ing, N. H. and B. W. O'Malley. New York, Raven Press. Making use of complementary DNA libraries to study growth mechanisms. Steroid hormone receptors. Encyclopedia of Reproduction.