Erythema multiforme is an allergic reaction with many different causes. It can affect people of all ages and is often more severe in children and young adults. Erythema multiforme often starts as a red rash on the palms, soles, and back of the hands. It can spread to the trunk, face, and mouth in severe cases.
Some people only have erythema multiforme in the mouth.
As the skin lesions age they often look like small targets with purple to dusky centers surrounded by red rings. The condition can be associated with fever, muscle aches, and not feeling well. Erythema multiforme is not contagious. Some people have recurrent episodes of erythema multiforme, usually due to cold sores or herpes infection. A mild cortisone applied directly to the irritated skin areas, colloidal baths, and wet compresses may be helpful to facilitate the clearing of the lesions.