As most insecticides are toxic to honey bees and other pollinating insects, applications should be made in late evening and directed to the base of plants. If only a few vines are present, keep a close check on them. Should any wilting occur, check the base of plants for signs of excrement and borer damage. If there is evidence of borer activity, remove the borer by slitting the vine with a sharp knife and removing the larva. Then cover the injured area with moist soil.
Some gardeners put a shovelful of soil at one or more locations along each vine.
This is to encourage the plant to develop a supplementary root system and thus overcome squash vine borer attacks at the base. Treat plants before first bloom. 50WP 2 tbsp. Repeat at weekly intervals as needed. The base of the plant is the critical area.