Small fluid filled blisters called vesicles appear on the hands and feet. They are most common along the edges of the fingers, toes, palms and soles. The vesicles produce intense itching .
Scratching leads to skin changes with thickening and an eczematoid appearance.
Scratching may also lead to secondary infections . Uninhibited scratching and skin trauma may lead to an eczematoid type reaction which is more difficult to treat and has a longer healing time. The cause is unknown but may be aggravated by exposure to skin irritants such as solvents, detergents, and frequent washing. This condition was once thought to be caused by trapping of sweat in the skin, forming vesicles or bullae, and causing inflammation, typically with severe itching. Pictured here is the classic involvement of the sides of the fingers also with palmar vesicles and bullae.