The nature of the signal pathway is currently being studied. In studies using normal, transgenic and gene knockout mice, we have shown that intravenous infection of viable allogeneic lymphocytes can lead to inactivation of T cells, and are investigating whether tolerance is produced by veto cells. Preliminary data suggest that NK cells exist in subsets differing in specificity that are subject to selection during ontogeny.
Studies use short term tissue culture and long term cell lines.
R.G. J. Immunol.