Avoid becoming pregnant while taking PEG-Intron. In some patients who already have an autoimmune disease, the disease worsens on PEG-Intron. You can reduce some of these symptoms by injecting your PEG-Intron dose at bedtime. Many patients become extremely tired while on PEG-Intron. Nausea, loss of appetite, and weight loss, occur commonly.
Some patients develop changes in the function of their thyroid.
Symptoms of thyroid changes include the inability to concentrate, feeling cold or hot all the time, a change in your weight and changes to your skin. Some patients develop problems with the way their body controls their blood sugar and may develop high blood sugar or diabetes. Redness, swelling, and itching are common at the site of injection. If after several days these symptoms do not disappear contact your doctor. You may get a rash during therapy.