In toxemia of pregnancy during the 2 hr prior to delivery. Flushing, hypotension, circulatory collapse, depression of the myocardium. Suppression of knee jerk reflex can be used to determine toxicity. Respiratory failure may occur if given after knee jerk reflex disappears. Hypocalcemia with signs of tetany secondary to magnesium sulfate when used for eclampsia.
Serum levels can predict symptoms of toxicity.
Hemodialysis and peritoneal dialysis are effective. IV Infusion Anticonvulsant. Oral Solution Laxative.