Although the salivary glands are virtually always affected, biopsy of a major salivary gland is rarely necessary. The histopathological features seen in minor salivary glands are similar to those seen in the major salivary glands, although the myoepithelial hyperplasia is absent. The seromucinous glands of the larynx may be involved, leading to inflammation of the larynx similar to that seen in the salivary glands. Clinically, this involvement produces edema, erythema, dryness, crusting, and hence, chronic hoarseness. Biopsies of the larynx reveal histological findings similar to those seen in the salivary glands.
Treatment is symptomatic, and antireflux and anti-inflammatory medications are sometimes prescribed.
Oropharyngeal angioedema associated with the use of angiotensin-converting enzyme inhibitors. Laryngeal involvement in toxic epidermal necrolysis. Head and neck manifestations of autoimmune disease. Rheumatoid nodules of the larynx. Upper aerodigestive tract manifestations of cicatricial pemphigoid.