Drug description Methotrexate is used alone or in combination with chemotherapies, surgery or radiation for treatment of cancers, lymphomas, leukemias, rheumatoid arthritis, and severe psoriasis. Side effects Treatment with methotrexate, as with other chemotherapy agents, can have many side effects such as upset stomach, nausea, vomiting, liver toxicity, anemia, leukopenia, and thrombocytopenia. Some drugs, such as anti-inflammatory agents and acyclovir , can increase the toxicity of methotrexate. Dosage Dosage reduction is required if you have any kidney impairment.
Treatment is by mouth, intramuscular or intravenous injection, or injection into the spine.
Dosage depends on the condition being treated. How long it may take to work Effectiveness of treatment can be seen in improvement of blood markers in leukemia, decrease in size and spread of non-Hodgkin s lymphomas and other solid cancers, resolution of skin lesions in severe psoriasis, decreased joint pain and swelling, and improved mobility if you are being treated for rheumatoid arthritis. Managing side effects Drink at least 2 quarts of high calorie fluids such as juices and nectars per day. If treatment is in pill form, take 1 hour before or 2 hours after meals. Report any unusual bleeding to your doctor.