The model system most commonly used is the induction of plasma cell tumors by introducing materials such as paraffin oils, silicone gels, or solid plastic objects into the peritoneal cavities of genetically susceptible mice. These materials induce chronic inflammation on peritoneal surfaces and connective tissues. Plasmacytomas develop and progress in these microenvironments, which provide an experimental system for exploring the relationship of chronic inflammation and neoplastic development. Research efforts focus on three aspects of this complex problem. Most other strains of mice are resistant.
Work is directed toward explaining the pathogenesis of chromosomal translocations.
The major plasma cell neoplasm in humans is multiple myeloma. While peritoneal plasmacytoma development in mice has notable differences from multiple myeloma, it nonetheless provides a model system for understanding the pathogenesis of plasma cell neoplasia. Hopefully, such a system will be useful for finding means to arrest the progression of these tumors or to prevent them entirely. Cancer Res .