We shall describe how we simulate it for father, simulating the distribution for mother is analogous. Simulating uninformative sharing. The only ways in which we get uninformative sharing for father is if the father is homozygous or if both parents are heterozygous with same pair of alleles. Since we are free to assign alleles at sharing locus, we can make sure that the second case never happens. Simulating known sharing.
Sharing is achieved if both sibs have same alleles.
It is a way to make sure that results of sibships of large size do not make the significance of results of smaller size negligible. We can further restrict these sibpairs according to their affection status. This is the desirable option when we have enough sibpairs that are affected. It is provided for completeness and to incorporate the case where the user wishes to use the WP statistic to weight the sibpairs according to their affection status and size of sibship. We can use the subsets defined with respect to the binning loci in two distinct ways to do ASP analysis at the sharing locus.