Extensive oral involvement may cause tooth loss, pain and ulceration. Pulmonary KS presents with intractable cough, bronchospasm, hemoptysis, chest pain, and dyspnea. Findings will include subcutaneous nodular lesions on the skin or oral cavity. This disease is usually asymptomatic, except when it presents with intestinal obstruction or GI bleeding. It may also cause protein-losing enteropathy.
Visceral disease is uncommon in absence of extensive cutaneous disease.
Lymphedema associated with KS usually appears in patients with visible cutaneous lesions, causes edema out of proportion to the extent of visible lesions. Common sites include the face, neck, penis, scrotum and lower extremities, and usually a whole contiguous area is involved. Disease may be striking and rapidly progressive. CXR typically shows diffuse interstitial infiltrates, often accompanied by nodules and pleural effusion. In the presence of constitutional symptoms, negative cultures for infectious agents.