It helps your body's system relieve pain in two important ways. Ultram is a centrally acting synthetic analgesic compound that is not derived from natural sources nor is it chemically related to opiates. Norepinephrine and serotonin are the two major amines responsible for pain sensation. Norepinephrine is involved in the transmission of impulses from the end of one nerve fiber to the next.
Serotonin acts as an important nerotransmitter in the brain.
Another role of serotonin is regulation of stable mental processes. Racemic Ultram is rapidly and almost completely absorbed after oral administration. Taking Ultram with food does not significantly affect its rate or extent of absorption. Therefore, it can be administered without regard to food. The mean peak plasma concentration of racemic Ultram occurs about two hours after a single 100 mg oral dose in healthy subjects.