Since histamine is the major chemical agent in allergic reactions, this often provides relief. Antihistamines have been around for a long time. Unfortunately, the older antihistamines also affect one's brain, making you very sleepy. There are newer antihistamines available that do not sedate you nearly as well as the older agents. Steroids Steroids, which are hormones normally produced by your body, help regulate many bodily functions including inflammation.
Steroids have their drawbacks.
Your body must make steroids all the time for many processes to work right. We can use oral steroids to relieve allergic rhinitis. However, we try not to do so unless someone is really miserable. I use nasal steroids on myself mainly before and during the ragweed-pollen season, when my allergies are at their worst. The mast cells release many different substances when they are stimulated, including histamine.