This is an important distinguishing feature of epitheliotropic versus nonepitheliotropic cutaneous lymphomas. High power section of Fig. 3 showing a nodular to dense perivascular collection of lymphocytes in the deep dermis. The lymphocytes are small, well differentiated and have little cytoplasm. In humans, CTCL follows a chronic, progressive, and indolent course, eventually developing into fatal lymphoma or a leukemic form called Sezary s syndrome.
Visceral metastasis occurs in both the lymphoma and leukemic form.
In this regard, canine MF differs from human MF, in which a CD4 immunophenotype predominates. However, Done et al. noted that the most common clinical signs seen in African hedgehogs at the Baltimore Zoo were anorexia and weight-loss 4 . Most reports of neoplasia in African hedgehogs describe hematopoietic neoplasms. Hruban et al. Raymond et al.