Kurumi's SignMaker Create your own freeway signs using this cool Java applet. Interstate 57 I-57 is the backbone of Southern Illinois. US highways Several national routes pass through Southeast Missouri, including US 60, US 61, US 62, US 67, US 160, and US 412. While not an interstate, US 60 does serve as the east-west backbone of Southern Missouri.
Some sections are at or near interstate grade, while some are still two lanes.
It joins I-57 near Charleston. US 60 bypasses Dexter and Poplar Bluff, joins US 67 for a stretch, and then branches off as a two-lane road, bypassing Ellsinore, Van Buren, and Winona on its way westward to Springfield. US 62 US 62, one of the lesser known highways, criss-crosses the Bootheel on a rather haphazard alignment. It joins US 61 southward to New Madrid, and then turns due west to Malden and Campbell, before sliding into Arkansas near Piggott. US 67 US 67 is a major highway that connects Little Rock, AR with St. Louis.