If you let your personal life dictate your business activities you might not have a business to worry about. Everyone needs to understand that there are times when you are not to be disturbed. This might mean a closed door or some sort of signal . One person I know has a special hat that he wears when he wants to let his family know that the do not disturb sign is out. Decide when your body clock is at its optimum.
Some people are more productive in early morning, others late at night.
Find out when you do your best work and then schedule that time for office hours. Don't let neighbors and friends or associates steal your time or ask you to do favors because you just happen to be home during the day. This can become a real time thief if you allow friends and family to think that because you are running a business out of your home you are available to drop everything for a cup of coffee or to do them a favor. Don t answer the home phone during business hours. If you don t already have one, get an answering machine or voice mail system for the home phone.