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Subclinical hypothyroidism is the most common disorder.
This is the most common cause of thyrotoxicosis in all age groups. Autoantibodies directed at the TSH receptor stimulate both thyroid hormone synthesis and thyroid growth. ATD are first line therapy for most patients since Graves disease most commonly presents in younger women. ATD are safe but agranulocytosis and hepatitis may rarely occur. Both appear to be dose related and reverse upon discontinuing the drug.