Treatment consists of gastric lavage and general supportive measures.
Acidification of the urine will increase renal elimination of trimethoprim. Peritoneal dialysis is not effective and hemodialysis only moderately effective in eliminating the drug. If signs of bone marrow depression occur, trimethoprim should be discontinued and the patient should be given leucovorin 3 to 6 mg intramuscularly daily for three days or as required to restore normal hematopoiesis.