Group B rotaviruses are the only rotaviruses which cause syncytia or the fusion of infected cells. Group C Rotaviruses 1. Like Group A strains are also the cause of primarily childhood diarrheal illness. Group C rotavirus infections are primarily associated with food-borne institutional outbreaks of childhood diarrhea and recent Group C outbreaks have occurred in Japan and England. Group A Rotaviruses are the predominant cause of rotavirus disease throughout the world.
Severe dehydration is the primary cause of morbidity and mortality.
SubGroup Group A rotaviruses can be subtyped by monoclonal antibodies. Based on VP6-specific antibodies. All human subgroup I Rotaviruses are G-serotype 2. Serotype Rotavirus Serotypes 1. Originally based on cross-neutralization of viruses by sera from animals hyperimmunized with purified rotaviruses.