The mode of inheritance is not yet known. Physical examination findings are also those of CRF including dehydration, stomatitis, pale membranes and small, irregular kidneys. Laboratory findings include azotemia, hyperphosphatemia, non regenerative anemia, acidosis and isosthenuria. Proteinuria is usually mild or absent but occasionally can be severe. Although treatment with DMSO or colchicine may reduce the rate of amyloid deposition, experience is limited.
Treatment is primarily supportive treatment of chronic renal failure .
Familial renal amyloidosis in the Sharpei dog is also called Sharpei fever or Sharpei hock syndrome as it begins with episodes of fever and swollen hocks. The fever and joint swelling are self limiting but often reoccur. Signs may develop in pups or adults. Renal and hepatic amyloid deposition leads to renal or hepatic failure. Renal amyloid deposition may be medullary or glomerular.