Any isotype or allotype target would recognize large numbers of normal B-cells as well as the tumor. They are both purely chemical responses to caustic irritants. They are both referred to as allergic contact dermatitis and are both cell-mediated immune reactions. Neither is a cell-mediate immune response. They both depend on humoral as well as cell-mediated immune responsiveness.
Traumatic injury can increase the risk of disease.
Pigs are not inbred. The contribution of traumatic damage of this kind has long been recognized to be associated with human disease as well. Different cells within a single tumor are likely to be fairly homogeneous in their levels of expression of cell surface antigens. This heterogeneity has many implications for diagnosis and therapy. Antigenic competition generally has the effect of increasing immune responses.