Constipation and small pupils are the last. Although the feelings of euphoria lessen, the drug provides enough pleasure to be reinforcing. The signs of withdrawal include, watery eyes, runny nose, yawning and sweating. Heavy users experience mild withdrawal as soon as the most recent dose wears off. As withdrawal continues the user feels restless and irritable and loses his appetite.
Symptoms are similar to that of the flu.
At peak the symptoms include diarrhea, shivering, sweating, general malaise, abdominal cramps, muscle pains as well as difficulty sleeping. The craving for heroin will last for months, long after the physical symptoms of withdrawal have ceased. There are so many factors that affect the action of the drugs, that it is impossible to accurately consider them all. They include, but are not limited to, the user's mood, body chemistry, other medications or illnesses, and psychological history. Even a medical professional would not be able to say for sure what the effect of an interaction will be.