Outbreaks most often occur in winter and spring, but a person may become ill with fifth disease at any time of the year.
Symptoms begin with a mild fever and complaints of tiredness.
After a few days, the cheeks take on a flushed appearance that looks like the face has been slapped. There may also be a lacy rash on the trunk, arms, and legs. Not all infected persons develop a rash. Most persons who get fifth disease are not very ill and recover without any serious consequences. However, children with sickle cell anemia, chronic anemia, or an impaired immune system may become seriously ill when infected with parvovirus B19 and require medical care.