Adenylate cyclase, phosphoinositide-mediated regulation, phosphodiesterases and protein kinases. Review of biological effects of free radicals and reactive oxygen and nitrogen species with a view toward pharmacological intervention. Analysis of literature implicating free radicals in disease processes. Processes important to nervous system functioning emphasized. Includes receptors, theories of receptor activation, chemical transmission, membrane potential, membrane responsiveness, transmembrane signaling, membrane ion pumps, voltage-operated channels, and drug absorption, distribution, metabolism, and elimination.
Student reads articles published on each topic.
Emphasis on practical problem solving, data analysis, and presentation of methods important to understanding published data and designing new experiments in this area of research. Emphasis on experimental problem solving, data analysis, and presentation. Emphasis on practical problem solving, data analysis, and presentation methods important to modern scientific work. Emphasis on mechanisms whereby drugs and other foreign organic chemicals affect dysmorphogenesis, functional abnormalities, and other types of permanent and semi-permanent embryotoxic effects. Emphasis on critical evaluation of research and development of presentation skills.