E-IPV given to infants and children, OPV later to control widespread outbreaks. B. Rabies Fig 22.11, 22.12 1. Bullet shaped rhabdovirus produces a fatal encephalitis 2. Acquired from bite of infected animal. Virus can also cross mucous membranes and there have been reported cases of rabies in cave explorers evidently from airborne virus in the moist cave environment 3.
Virus enters via bite, multiples locally in muscle and connective tissue.
Then enters and travels along peripheral nerves to CNS and produces encephalitis. This is why bites on nerve-rich areas such as the face are more dangerous and have a shorter incubation 5. In animals - some get a form of paralytic rabies 6. After death - fluorescent ab on brain tissue will detect rabies virus includsions. Now there is a human diploid cell vaccine administered in 5 or 6 injections over a month.