Antihistamines Enhanced sedative effect, drowsiness and lack of alertness, dizziness. Antihypertensives Enhanced hypotensive effect, sharp reduction in blood pressure. Antiulcer medications Increases the availability of alcohol, even in small intakes of alcohol. Prolonged release capsules The capsule dissolves more rapidly, active ingredient released without delay. Hypnotics Strong enhancement of effect of hypnotics depressing central nervous system.
Tranquillizers Enhances sedative effect, impairs alertness and judgement.
Isoniazide and rifampicin are used for the treatment of tuberculosis. Ingestion of AC reduces the availability of isoniazide in the blood, whilst CC reduces that of rifampicin. In both cases efficacy of treatment is reduced . The mechanism of these interactions are still not understood. Tyramine is found in some wines and beers, and interacts with some antidepressants, such as monoamine oxidase inhibitors provoking a sharp increase in blood pressure .