Aggression tends to be a problem encountered in certain breeds more than others. Pure psychotic aggression, in my opinion, cannot. Always seek professional help with aggression. Abnormality seems to be psychological. The animals I have seen seem to be almost autistic.
Some dogs are non responsive, while others just seem depressed.
In many cases the dog has developed this way either from a series of negative experiences during development, or it is in a poisonous household and they just shuts down emotionally. To help owners understand some of the difficulties and frustrations they are having and why. There are numerous books and seminars you can attend if you really want to know more. The owner work takes much more time and energy. Most owners have unrealistic expectations of dog training.