Monotherapy with any of these drugs is strongly discouraged because of the high likelihood of drug resistance developing. Given the prevalence of tuberculous infection in the community, many who are seropositive for HIV are likely to have been infected by M. tuberculosis and to have been, or still be, positive to the tuberculin test. Such persons are at risk of acquiring tuberculous disease and of spreading it to others. Since HIV infection can lead to anergy, a chest x-ray is recommended for those who are HIV seropositive and tuberculin test negative. If illness supervenes, tuberculosis should be excluded regardless of the tuberculin status.
Tuberculosis is a reportable disease.
Consultation with TB Control should be sought. Mycobacterium Tuberculosis Treatment Tuberculosis is a reportable condition and should be managed in consultation with an experienced specialist. Drug susceptibility assays will be routinely performed. For cases of previously treated tuberculosis, two drugs to which the patient has not been previously exposed should be added. Drug interactions may complicate therapy.