RAD50 and RAD51 define two pathways that collaborate to maintain telomeres in the absence of telomerase. Mol Gen Genet. Mol Cell Biol. Chromosome break-induced DNA replication leads to nonreciprocal translocations and telomere capture. Minisatellite origins in yeast and humans.
Telomere maintenance is dependent on activities required for end repair of double-strand breaks.
Expansions and contractions in a tandem repeat induced by double-strand break repair. Genetic analysis of yeast RPA1 reveals its multiple functions in DNA metabolism. Mcm1 regulates donor preference controlled by the recombination enhancer in Saccharomyces mating-type switching.