Severe disease in one eye leading to an RAPD will not lead to anisocoria. Some conditions will lead to a marked reduction of visual acuity with an RAPD, while others spare the central vision. Usually there will be a loss of vision or a horizontal cut in the visual field. This includes direct ocular trauma, orbital trauma, and even more remote head injuries which can damage the optic nerve as it passes through the optic canal into the cranial vault. Optic nerve infections or inflammations - Cryptococcus can cause a severe optic nerve infection in the immunocompromised.
Sarcoidosis can cause inflammation of the optic nerve.
Lyme disease can affect the optic nerve. Usually retinal disease has to be quite severe for an RAPD to be clinically evident. An RAPD can often be seen if the macula is detached, or if at least two quadrants of retina are detached. If unilateral and severe, an RAPD can be seen. Intraocular tumor - Retinal and choroidal tumors including melanoma, retinoblastoma, and metastatic lesion could lead to an RAPD if severe.