Interlobular arteries show intimal thickening that is loose, myxoid and edematous. Fibroblasts and red cell fragments may be present in the thickened intima. Fibrin thrombi may occlude lumens. Chronic or healed arterial lesions show concentric intimal fibroelastosis. The disease is manifest by excess fibrosis in organs throughout the body.
Tissues frequently involved are skin, gastrointestinal tract, kidneys, heart, muscles and lungs.
Robbins Pathologic Basis of Disease. Renal Disease, 2nd edition, Churg et al. Search Medline at National Library of Medicine Please be patient during transfer. Medline will open in a new window.