Zoo blots are one tool used in locating genes for specific human genetic diseases.
Give some evidence for why we think cancer is caused by genetic changes in the DNA and not just epigenetic changes in cellular physiology. Describe the basic structure and life cycle of a retrovirus. One way that oncogenes were initially found was by transfecting DNA from a bladder carcinoma into mouse 3T3 tissue culture cells. Describe this experiment and tell how the actual oncogenes were isolated.