Resistance can develop quickly. It is very important to take protease inhibitors according to instructions, on schedule, and not to skip or reduce doses. The capsules are 200mg, so you will take 6 capsules every 8 hours. Researchers are studying twice a day dosing of saquinavir. Some physicians prescribe saquinavir in combination with another protease inhibitor, ritonavir.
Studies are underway using a single daily dose of saquinavir taken with a small amount of ritonavir.
Saquinavir should be taken within two hours after a full meal or a large snack. Your pharmacist should keep saquinavir refrigerated. The side effects of saquinavir are usually mild. Most people can take it with no problems. However, some people get nausea, diarrhea, upset stomach, and heartburn.