X-ray fluorescence 2. Thinks the most difficult part of this project is getting the protein itself - need to think very hard about this. Structures could help in defining these libraries. I warn you against overselling the value of structural genomics in pharmaceutical design - structure has limited value in pharmaceutical development Can possibly be valuable to assign function and folds. Many times - proteins can serve multiple functions.
Structures can provide useful clues regarding how to design compound libraries for screening.
B. Honig - Computational tools for deducing function from structure are developing. Need many more structures. Structures of human proteins will be very valuable for designing pathogen-specific molecules. Broad public utility 2. Value to health and agriculture 3.