Benzoyl peroxide is best at killing P. acnes and may reduce oil production. Resorcinol, salicylic acid, and sulfur help break down blackheads and whiteheads. Salicylic acid also helps cut down the shedding of cells lining the follicles of the oil glands. Topical OTC medications are available in many forms, such as gel, lotion, cream, soap, or pad. In some patients, OTC acne medications may cause side effects such as skin irritation, burning, or redness.
Some people find that the side effects lessen or go away with continued use of the medication.
Severe or prolonged side effects should be reported to the doctor. OTC topical medications are usually moderately effective in treating acne when used regularly. Patients must keep in mind that it can take between 4 and 8 weeks before they notice an improvement in their skin. Prescription and OTC benzoyl peroxide work in the same way. Isotretinoin is an oral drug and is usually taken once or twice a day for 16 to 20 weeks.