Whether physical dependence develops in unresolved at this time. Reports of withdrawal effects in humans are rare and are associated with very high use levels. In animal studies, given THC does not relieve withdrawal. On the whole, THC is not considered an addictive agent. Other THC side effects include suppression of the immune system, lower testosterone levels and lower sperm count.
Tolerance does develop, but only to a minor degree.
Cross tolerance has been shown among the other cannabinoids and various CNS depressants. Adulterants and additives do pose a potential problem. Street marijuana may be laced with a variety of adulterants. UNIT 11 TEST 1. The publication of the LaGuardia report b.