It seems to be more effective and have fewer undesirable side effects. Potassium bromide works by competing with chloride ions for access to brain tissues. As bromide levels in the brain rise and chloride levels drop, electrical activity in the central nervous system is inhibited thus making the initiation of a seizure difficult. This medication is generally reserved for dogs who cannot tolerate phenobarbital for seizures control due to unacceptable side effects or lack of effectiveness. It is generally mixed in water and provided as a liquid solution.
Some nausea is associated with the administration of potassium bromide.
This is generally controlled by giving the medication with food. Since potassium bromide is a salt, excess thirst and urination can be observed with this medication. Drowsiness or grogginess, which can be marked, is not abnormal during a loading period when potassium bromide therapy is started. It is important not to give more potassium bromide to a groggy pet even if another dose is due. For this reason bromide levels are monitored periodically.