Additionally, we are identifying the beta cell antigens recognized by our TCR transgenic using peptide mimics. More recent studies focused on another autoimmune disease, experimental autoimmune encephalomyelitis. The studies turn on the identification of antigens released during the relapse and remitting phase of disease. Genetic control of diabetes progression. Beta cell apoptosis in T cell-mediated autoimmune diabetes.
T cells induce acute pancreatitis and diabetes in immune-compromised NOD mice.
Katz JD, Benoist C, Mathis D. T helper cell subsets in insulin-dependent diabetes. Mathis D. Following a diabetogenic T cell from genesis through pathogenesis.