These toxins are used by extracting the microbe or using whole organisms. See Biological Control below. Field results in landscapes have not been consistent in efficacy. Botanicals are plant extracts, usually alkaloids, which have insecticidal properties. Many of these chemicals have not been fully tested and many have striking adverse affects on mammals.
Some people are very allergic to the compounds.
Highly toxic to fish, and it was used originally by South American Indian to collect fish from lakes and rivers. Very toxic to pigs. Though having low dermal toxicity, it is a powerful irritant which if inhaled can cause severe circulatory and respiratory failure. In spite of some magazine articles, this product is only registered for vegetable pests. Neem is used as a general cleaning chemical and is found in tooth paste.