The facility is located in rooms 357 and 363, Animal Sciences Laboratory and occupies 696 sq. Animals are housed in the Animal Care Facility of the Office of Lab Animal Resources in the basement of the Edward R. Madigan Laboratory within a specific pathogen free area. The facility is staffed with a director and one full-time research specialist. The methodology employed in the production and subsequent evaluation of transgenic mice is presented schematically. Add the two pictures, the one showing the dish on the microscope and Melissa looking into the microscope both back into the page, if there is room.
Transgenic animals are among the most useful and exciting research tools in the biological sciences.
These animals have a foreign gene incorporated into their genome which is passed on to their offspring. Transgenic mice were first produced in 1980, and have become a research tool in many disciplines. Although there are several methods of producing transgenics, the most widely used is microinjection of the DNA is injected into single cell embryos. These are then transferred into pseudopregnant recipient mice. After the pups are born, they are screened for the presence of the new gene.