I' like all of us to keep in mind as we reflect on the presentations already given and those that will follow mine. Genomic studies can be analyzed at many different levels. Things that are true at the molecular level do not necessarily translate into public health issues. Inclusiveness cannot be assumed at any stage in the scientific endeavor. Exclusiveness is often the rule in American biomedicine and the pattern of sampling often reflects power relationships.
Scientists are products of their culture.
For example, consider the case of Celera. Celera, in its race with the Human Genome Project to sequence the human genome, relied on only one individual sequenced three times. Science is full of imbedded cultural assumptions. As long as there is no competition, the real purposes of mega efforts often become clear. Remember from your geometry, it takes two points to make a line.