Confirm that this indeed is the problem with your hand. Prescribe therapy as above. Perform surgery to remove the abnormal tissue, usually through zig-zag cuts in the palm. Surgery may require skin grafts or other tricks to correct the tightness of the skin of the palm. Surgery is usually recommended to help straighten out bent fingers rather than to prevent the fingers from becoming bent.
Surgery is currently the only reliable treatment.
A variety of medications have been tried over the years, but a medical cure is not yet available. The most exciting prospect of current research involves injection of collagenase, an enzyme which dissolves the main protein found in Dupuytren's tissue. This treatment has not completed testing, but might be available as early as 2001. It depends on how bad the problem is, as well as the person's age, sex, and other medical problems. Most people who have had surgery for Dupuytren's feel that they made the right choice to have surgery.