So within a short time, there will be millions of germs resistant to penicillin. In this kind of instance, the information to resist the antibiotic was already there in the bacterial population it did not arise by itself, or in response to the antibiotic. That some germs were already resistant to man-made antibiotics before these were invented is common knowledge to microbiologists. Soil samples from villages where modern antibiotics had never been used show that some of the germs are already resistant to drugs like methicillin which have never existed in nature. Bacteria revived from the frozen intestines of explorers who died in polar expeditions carried resistance to several modern antibiotics, which had not been invented when the explorers died.
Some germs directly transfer their resistance to others.
In an amazing process, the closest thing to sex in bacteria, one germ inserts a tiny tube into another, and a little loop of DNA called a 'plasmid' transfers from one to another. This sort of gene transfer, which can obviously pass on information for resistance to a drug, can even happen between different species of bacteria. Notice, again, that the information for the resistance must already exist in nature before it can be passed on. There is no evidence of anything totally new arising that was not there before. This is information transfer, not information creation.