Our main aim is to work out some of the peripheral mechanisms which underlie the increased sensitivity to pain which results from nerve damage. With Dr Liu Tao, we are using behavioural measures of pain thresholds in rats to examine the pharmacological effects of inflammatory mediators and their antagonists on hyperalgesia due to nerve damage. Recent Publications 44.
Zinc alleviates thermal hyperalgesia due to partial nerve injury.
NeuroReport 10, 645-649. Hyperalgesia due to nerve damage - role of nerve growth factor. Pain 81, 245-255. Hyperalgesia due to nerve injury - role of prostaglandins. Neural basis of chronic pain - peripheral and central mechanisms.