This Publication Is Searchable The Merck Manual of Diagnosis and Therapy Section 11. Hematology And Oncology Chapter 134. Hypergammaglobulinemic purpura is a syndrome that primarily affects women. These lesions leave small residual brown spots.
Vasculitis is seen on biopsy.
Periorbital purpura or a purpuric rash that develops in a nonthrombocytopenic patient after gentle stroking of the skin should arouse suspicion of amyloidosis. In some patients a coagulation disorder develops, apparently the result of adsorption of factor X by amyloid. All rights reserved.