All parts of Jimsonweed are poisonous. Leaves and seeds are the usual source of poisoning, but are rarely eaten do to its strong odor and unpleasant taste. Poisoning can occur when hungry animals are on sparse pasture with Jimsonweed infestation. Most animal poisoning results from feed contamination. Jimsonweed can be harvested with hay or silage, and subsequently poisoning occurs upon feeding the forage.
Seeds can contaminate grains and is the most common poisoning which occurs in chickens.
Poisoning is more common in humans than in animals. Children can be attracted by flowers and consume Jimsonweed accidentally. In small quantities, Jimsonweed can have medicinal or haulucinagenic properties, but poisoning readily occurs because of misuse. Ingestion of Jimsonweed caused the mass poisoning of soldiers in Jamestown, Virginia in 1676. Jimsonweed toxicity is caused by tropane alkaloids.