Large doses of PCP may result in a convulsive seizure, coma and death. Mood disorders occur and the user may become violent, irrational and potentially harmful to self and others. The user may experience panic, confusion, anxiety, depersonalization and loss of control. While relatively rare, flashbacks, the spontaneous reappearance of the drug experience after use has ceased, may occur. In order to avoid the abstinence syndrome, the addict becomes preoccupied with acquiring the drug.
Tolerance develops rapidly.
The use of cocaine can cause death by cardiac arrest or respiratory failure. Stimulants are addictive and while withdrawal from stimulants is less dangerous than with depressants, depression can make a person vulnerable to suicide. THC is fat-soluble and can remain in the body up to three weeks after smoking one marijuana cigarette. Consequently, even the occasional user can be detected through urinalysis. Research indicates that regular use may have long term effects on the user's brain, heart and reproductive organs.