The soul is capable of enjoying the friendship of God and of reciprocating His love. The body is compared to the house, and the soul to him that lives in the house. Man is more noble than the house he lives in, so is the soul more noble than the body. As clothing is worth less than the body, so the body is worth less than the soul that it covers. Even so the soul is more honorable than the body.
Sin is what causes a soul to be lost.
Sinning against God is what ruins the soul and causes it to be sent away from God. Sin is what makes the soul hateful in the eyes of Divine Justice. A soul is lost when it is separated from God and His favor and is under His curse and wrath. These words of Paul express the second death and the torments of Hell. Unless satisfaction is made for the sins of the soul by the blood of Christ, this is to be the future condition of every sinning soul on earth.