Such loss may cause paresis and affect both vision and psychic functions. Individuals with the DR2 variant of MHC genes are most susceptible to the disease. The disease affects mainly individuals carrying the DR4 variant of MHC genes. This feature can now be used both to make better prognoses and in aiding efforts to change immune reactions that involve the DR4 variant while leaving other reactions intact. Towards Novel Vaccines.
Vaccination is the most important way to make use of the immune system in medicine.
By vaccination we prepare the immune system to respond earlier and more efficiently against the antigen in question. The discovery of Doherty and Zinkernagel has taught us important things to consider in the design of future vaccines. It has led to the search for the critical components of viruses and bacteria as well as cancer cells that are recognized together with MHC molecules. We also understand that the MHC molecules of the vaccinated individuals can influence the result. Attempts are now being made to vaccinate against recurrence and spread of certain forms of cancer within the body, metastasis.