Any general information about driving a motorcycle would be helpful. Thinking about buying one in U.S., driving into Mexico, and using it as my only means of transportation.
Urban conditions can be very congested and road and street conditions are quite variable.
Expect to find potholes, sand, speed bumps, livestock, pedestrians, etc. Some highways have heavy traffic, remember that most everything moves by truck or bus. In addition, there aren't nearly as many motorcycles in Mexico as the US, so drivers won't expect them. All of that increases the risk. On the other hand, most of the autopistas that I've traveled have had relatively light traffic.