Human uveal melanoma cells produce macrophage migration-inhibitory factor to prevent lysis by NK cells. Cytolytic T lymphocytes raised against a human bladder carcinoma recognize an antigen encoded by gene MAGE-A12. High frequency of autologous anti-melanoma CTL directed against an antigen generated by a point mutation in a new helicase gene. High frequency of autologous anti-melanoma CTL directed against an antigen generated by a point mutation in a new helicase gene. Engagement of the OX-40 receptor in vivo enhances antitumor immunity.
Tumors promote altered maturation and early apoptosis of monocyte- derived dendritic cells.
Induction of potent antitumor CTL responses by recombinant vaccinia encoding a melan-A peptide analogue. Expansion of tumor-T cell pairs from fine needle aspirates of melanoma metastases. Signaling Molecules in Metastatic Melanoma Patients' T Lymphocyte Subsets Expressing Distinct TCR Variable Regions. Functional analysis of antigen-specific T lymphocytes by serial measurement of gene expression in peripheral blood mononuclear cells and tumor specimens. T lymphocyte subsets expressing distinct TCR variable regions.