Failure to ovulate at 150-200 mg daily for 5 days usually necessitates use of other induction agents. The discrepancy may result from other causes of infertility as well as clomiphene citrate's potential ad verse effects on the cervical mucus and endometrium. Preg nancy will usually occur within four to six ovulatory cycles, and other regimens should be considered if clomiphene fails after this interval. Although clomiphene is generally well tolerated, side effects can Menotropins. Although human menopausal gonadotropin has been used to treat women who fail to ovulate or to Treatment cycles with human menopausal gonadotropin and urofollitropin must be carefully monitored with serum estrogen measurements and ultrasonographic evalu ation of follicular growth.
Transvaginal ultrasonography adds information on follicle number and size.
Treatment with human menopausal gonadotropin or urofollitropin is Most pregnancies occur within four to six cycles of therapy. The success of ovulation induction with menotropin varies with the etiology of anovulation. Women with hypothalamic amenorrhea have a Gonadotropin-Releasing Hormone. Although primary hypothalamic amenorrhea is the only approved indication for pulsatile GnRH administration, it has also been used suc cessfully to induce ovulation and pregnancy in women with other forms of anovulation.