However, all the enrolled patients had been resistant to multiple previous treatments. Additionally, they are all adults with stable lesions. There were no complaints about burning or irritation. It is well known that keratinocytes produce and are a target for vitamin D3. Because definitive understanding and treatment of vitiligo is not complete, several other theories and therapeutic trials have been studied.
Some investigators state that arachidonic acid and prostaglandins are stimulants of melanization.
This activity appears to be enhanced by exposure to UV light, because of the ability of light to isomerize 7-dehydrocholesterol into cholecalciferol that stimulates the liberation of arachidonic acid. E is one of the most potent activators of tyrosinase 6. Endocrine factors as effectors of integumental pigmentation. Parsad D, Saini R, Verma N. Combination of PUVAsol and topical Calcipotriol in Vitiligo. A preliminary Study.