Yet there has been no common forum to facilitate the dissemination of new knowledge to such an heterogeneous group of investigators. Sepsis is an international journal that promotes the interdisciplinary exchange of knowledge and ideas in this rapidly evolving field. Through a series of invited reviews, each focusing on a particular aspect of the study of the host septic response, Sepsis brings together the insights and perspectives of acknowledged authorities with the objective of facilitating the creative exchange of ideas and perspectives. The results of clinical trials designed to apply insights derived in the controlled circumstances of the laboratory to the management of critically ill patients have been disappointing and argue for a careful re-evaluation of many of our assumptions in this complex field. Sepsis strives to be not only informative, but provocative, iconoclastic, and integrative in the belief that scientific progress occurs best through collaboration, dialogue, and a willingness to challenge concepts that have become outmoded.
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