We have demonstrated that the ligation of specific macrophage receptors can exert a profound influence on cytokine production by these cells. Studies to determine the mechanism whereby receptor ligation influences cytokine production are underway. The goal of these studies is to determine whether we can predictable and reliably influence cytokine production by targeting antigen to specific cellular receptors on antigen presenting cells, such as macrophages or dendritic cells. Dr. Mosser is a Section Editor of The Journal of Leukocyte Biology and an ad hoc reviewer for several journals, including The Journal of Immunology and Infection and Immunity . He is on the Council of The Society of Leukocyte Biology and he is a member of the National Institutes of Health, Division of Allergy and Infectious Diseases Study Section on Bacteriology and Mycology.
Serum complement is responsible for the intracellular survival of Leishmania major .
Mosser, D.M. , Vlassara, H., Edelson, P.J. and Cerami, A. 1987. Leishmania promastigotes are recognized by the macrophage receptor for advanced glycosylation end-products. Noel, G.J., Mosser, D.M. and Edelson, P.J. 1989. Mosser, D.M. , Springer, T.S. and Diamond, M.S. 1992. Moors, M.A., Stull, T.S., Blank, K.J., Buckley, H.R. and Mosser, D.M. 1992.