The most evident lesions which characterizes MCF are epithelial necrosis of the gastrointestinal, urinary, and respiratory tract.
Secondary lesions consist of inflammation, lymphoproliferation and vasculitis.
Oral lesions Bladder Abomasum courtesy of WCVM Pathology Department courtesy of WCVM Pathology Department courtesy of WCVM Pathology Department Most lymphnodes are hyperplastic, swollen, and edematous. Hemorrhage and necrosis may occur in the lymphnodes during the terminal phases. There is a marked lymphacytic infiltration into the interstitium of various organs, such as the heart, liver, meninges, adrenal gland and kidney. Vascular lesions are evident throughout the body and can range from slight transmural lesions to thrombosis and hemorrhage. Material for a complete histological evaluation should consist of brain, lymphnode, adrenal gland, kidney, liver, and alimentary tract mucosa.