Adjuvant therapy for resected pancreatic cancer. Patients are randomized to treatment with 5-FU and radiation, versus gemcitabine and radiation. Randomization is between oral topotecan versus IV CPT-11. Patients with pancreatic cancer who have progressed following standard chemotherapy are treated with the experimental drug GBC-590. For patients with anaplastic oligodendrogliomas.
Treatment consists of either radiation alone versus chemotherapy plus radiation.
Patients with advanced head and neck cancers with underlying medical problems not allowing them to receive cisplatin chemotherapy are randomized to methotrexate versus Taxol. Patients are randomized to CHOP versus alternating chemotherapy combinations. Patients with widespread prostate cancer are treated with intermittent hormone therapy. Patients with prostate cancer following radical surgery are treated with radiation therapy plus or minus hormonal therapy. Patients with prostate cancer who have progressed following radiation treatment are treated with surgery.