Deficiencies of pyridoxine lead to anemia , poor growth, kidney stones, tooth cavities, skin lesions, and in advanced cases, death. There are no known toxicities. They are necessary for the bone marrow to produce red blood cells , and a deficiency of either can lead to advanced anemia. The quantity of white blood cells may also be reduced. Both vitamins are usually included in the diet and are found in organ meats.
Toxicities are of no concern.
Biotin is one of the most discussed of all vitamins, primarily because of its role in maintaining healthy skin and hair. It does much more than this, as it is necessary for growth, digestion, and muscle function. In some animals, it has been linked to litter size. Biotin deficiencies have been reported following the ingestion of raw egg whites. Raw egg whites contain an enzyme called avidin that acts to destroy biotin.