Late Neonatal Period Iatrogenic. Vitamin E deficiency hemolytic anemia. Possible folate and Vitamin B-12 deficiencies. Bone marrow failure. Half-life is about 13 days.
Young cells have normal activity while old cells are grossly deficient.
Thus, after an acute hemolytic event, G6PD levels are normal in this variant. Unlike Gd A-, these individuals cannot make RBCs with adequate activity and require multiple transfusions to stop the hemolytic crisis. Syndrome includes microcephaly, microphthalmia, absent thumbs, hyperpigmentation, cafe au lait spots, short status, renal anomalies, and heart anomalies. Associated with leukemia. Associated with thrombosis, web neck, cleft lip, short stature, increased fetal Hgb, pure red cell aplasia, leukemia.