We have found that HLA-DR2 gene from a Japanese population implicated in negative association with rheumatoid arthritis can protect mice from arthritis. The DR3 gene which is not a 550 created with RA does not influence the disease. HLA-DQ6 genes which are not linked to RA in humans, were found to be resistant to collagen arthritis, while an F1 between DQ8 and DQ6 are susceptible to arthritis with intermediate severity. We are currently making various combinations of double transgenic mice to simulate the potential human haplotypes. Role of HLA-B27 in spondyloarthropathy.
Studies are underway to understand the mechanism.
We have identified epitopes on allergens such as house dust mite, ragweed and rye grass, which are presented by HLA molecules. We have also generated an in vivo model with the HLA transgenic mice for asthma. Role of HLA genes in multiple sclerosis is being studied using EAD as a model in these mice. Both the DR3 and DQ8 gene play a role in disease. Mayo Foundation for Medical Education and Research.