Not cross-resistant with other alkylating agents. Rapidly cleared from plasma and metabolized.
Wafers are biodegradable in the brain when implanted into the cavity after tumor resection.
Released carmustine diffuses into the surrounding brain tissue. Delayed bone marrow toxicity may be observed. Safety and effectiveness have not been established in children. Renal failure, azotemia, decrease in kidney size. Reversible increases in alkaline phosphatase, bilirubin, and transaminase.