IgG heavy and light chains expressed in MS plaque-periplaque white matter. This characterization of the IgG repertoire found in MS brain will allow potential disease-relevant sequences to be identified. Recombinant antibodies prepared from these heavy and light chain variable regions will then be analyzed for specific binding to antigens in MS brain and used to screen MS cDNA libraries. Extraction and purification of active IgG from SSPE and MS brain. Identification of simian varicella virus homologues of varicella zoster virus genes.
Transcription start site and promoter region.
Restricted use of V H 4 germline segments in an acute multiple sclerosis brain.