The kidney perceives the decrease of fluid in the blood and aggressively retains as much fluid and salt as it can. This contributes to the body s fluid-overload state. Nephrotic-related swelling makes tissue puffy, soft, and impressionable to the touch. Edema is most common in the legs and feet, especially after standing all day. It can cause feelings of tightness in the extremities and may affect mobility.
Some people gain weight after fluid builds up in their bodies for a long time.
In addition to albumin, other important enzymes involved in cholesterol metabolism slip through the glomeruli, which contribute to high blood cholesterol. Complications Nephrotic syndrome is associated with renal failure. The disease that causes NS can damage the glomeruli and can interfere with their ability to clean the blood. The edema that is present in the legs may also be occurring in the kidney tissue itself and can interfere with the kidneys ability to clean the blood. This means that they are at risk for developing a blood clot in the legs or in the renal veins that transport blood from the kidney.