Tissues treated with photodynamic therapy often show platelet aggregation and vessel constriction leading to blood flow stasis. As indicated in the figure, vessel constriction occurs early in treatment and involves formation of platelet aggregates. A new recnnique was aevelopea to evaLuate tnejormation ojgaps between endothelial cells in blood vessels. Animals were given an injection of smallfluorescent microspheres that bind the areas of newly formed gaps between endothelial cells. The location of microsphere binding represents areas that vessel damage has occurred.
Spots represent areas with increased generation of receptors for leukocyte and tumor cell adhesion.
Expression of chemokine receptors along the vascular network in muscle. This image shows that the expression of this receptor is limited to postcap illary venules. Expression was not observed in capillaries or in larger venules. Vascular effects of photodynamic therapy. I protein on pulmonary endothelial cells in vivo.