Internet Explorer will give molecular images with Chime in some of the UMass Resources, but rarely works properly. On both Windows and Macintosh, it is perfectly OK to have both Internet Explorer and Netscape installed, or even multiple versions of each. You can then use whichever is better for a particular application. The problem with Internet Explorer is that Microsoft has never provided full plug-in support. More complicated ones, including all UMass Chime Resources, don't work properly.
Some controls fail or give incorrect results or incorrect images.
The biggest thing that Microsoft has not implemented is the best way for the browser to control Chime, called LiveConnect. Draw your own conclusions. Alternatively, future changes in Chime or javascript programming methods may allow better use of Chime in IE, but these are problematic and uncertain. Some of the earlier UMass resources will work with Chime 1, while the more recent ones require Chime 2. Those that require Chime 2 are listed in the Chime 2 section, and they check browser and Chime compatibility before starting.