Side effect of note is diarrhea. Cladribine is used to treat hairy cell leukemia, beta cell lymphoma and is associated with fever and sepsis. Topotecan is relapsed ovarian cancer where it can be quite effective and it causes diarrhea and dyspnea in some cases. Now we talk about new chemotherapy agents again, if we look at Taxol or paclitaxel, it works on the microtubules. Its cancer use is ovary, bladder, lung and breast.
Side effects are myelosuppression, neurologic symptoms and fatigue.
Vinorelbine or Navelbine, microtubule assembly. Lung, breast, myelosuppression and some neuropathy. Gemcitabine is one we re quite excited about. It can cause fever and lethargy and myelosuppression. I ll just sum up to point out that gemcitabine, as I mentioned, doesn t have a very high incidence of helping in these diseases.