As long as ferrets are fixed, it does not matter what combinations of sexes you keep. Descenting is not necessary for a ferret. Ferret's coats are oily and musky from being intact but neutering and baths will fix that. It will not stain or permanently mark your household. We recommend that you keep your ferret caged or confined to a single room of the house while no one is home.
Wire cages with levels are what ferrets prefer.
Caging protects the ferret as well as your house. Ferrets are inquisitive, fearless, and capable of getting into places that you never imagined. If their head can fit into something, then the body can follow. To ferret proof your home, we suggest that you start with getting potted plants out of their reach. Ferrets love to dig in dirt.