Corticobasal degeneration progresses gradually. The patient is unable to walk.
Symptoms vary among patients.
There is no treatment available to slow the course of corticobasal degeneration, and the symptoms of the disease are generally resistant to therapy. Antiparkinsonian drugs do not produce any significant or sustained improvement. Clonazepam may help the myoclonus. Occupational, physical, and speech therapy may help in managing disability. The course of corticobasal degeneration is one of inexorable progression until death, usually 6 to 8 years after diagnosis.