Hepatotoxicity is the most serious adverse reaction associated with anabolic steroid therapy. Reversible increase in BSP retention occurs early and appears to be directly related to the dose. Clinical jaundice, which is reversible when the drug is discontinued, may occur. The histologic picture is one of intrahepatic cholestasis with little or no cellular damage. Continued therapy may be associated with hepatic coma and death.
Virilization is the most common undesirable effect associated with anabolic steroid therapy.
Acne occurs frequently in all age groups. The first signs of virilization in the prepuberal male are phallic enlargement and an increase in frequency of erection. Hirsutism and increased skin pigmentation may also occur. Gynecomastia and testicular atrophy may occur. Chronic priapism, male pattern of hair loss, epididymitis and bladder irritability have been reported.