The chancres usually heal after 3 to 6 weeks even when untreated. The Secondary stage begins within a few days or up to 8 weeks after the ulcers appear. Symptoms include headache, nausea, vomiting, fatigue, appetite and weight loss, sore throat and slight fever. A rash can occur on arms, palms, soles, face and scalp. Drainage that occurs from this rash is highly contagious.
Some people experience hair loss.
In the Latent stage , physical signs and symptoms are usually absent. The rash may reoccur during this stage. In the Late stage , symptoms depend on which organs the disease has invaded. If it has invaded the nervous system, headache, dizziness, sleeplessness, seizures and psychosis may develop. Lesions, called gummas, may occur on the skin, bones or any body organ.