The concentrations of a number of synthetic hormone agonists and antagonists measured in the U.S. human population today are well within the range and dosages at which effects are seen in wildlife populations. Unless the environmental load of synthetic hormone disruptors is abated and controlled, large scale dysfunction at the population level is possible. For example, many sex- related characteristics are determined hormonally during a window of time in the early stages of development, and can be influenced by small changes in hormone balance. Evidence suggests that sex- related characteristics, once imprinted, may be irreversible. The British publisher, Elsevier Applied Science, will publish a book on this subject by next fall.
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