Serious interaction can occur with concurrent use of MAO inhibitors, Prozac, Zoloft, Paxil, Effexor, Celexa, Luvox, Imitrex, demerol, talwin, tricyclic antidepresssants, dextromethorphan, Tryptophan and Phentermine. Increased level of Meridia can occur with the concurrent use of Erythromycin or Ketoconazole. Under 16 years of age Concurrent use of other drugs as mentioned above. Phentermine acts by stimulating the release of norepinephrine and thus stimulating the metabolism. It also suppresses appetite.
Tolerance can develop, requiring an increase in the dose.
Heart disease Uncontrolled hypertension Hyperthyroidism Glaucoma Agitated state Within 14 days following the adminstration of MAO inhibitors Pregnant or nursing mothers Under the age of 16 Phenylpropanolamine Phenylpropanolamine acts by suppressing appetite. Ephedrine is an adrenergic drug and primarily has been used in the treatment of asthma. Ephedrine can raise blood pressure and increase heart rate and even induce heart arrhythmia which can result in death.