With the financial support of a major benefactor, George Blake, the school purchased the land now known as Blakefield in 1933. A year later, classes were held there for the first time for upperclassmen, while the freshmen continued meeting downtown. In 1941, the downtown campus closed. The seventh and eighth grades were added to the school in 1981, followed by a sixth grade level in 1988. The school was known as Loyola High School, Blakefield, until recent years, when the name was changed to Loyola Blakefield, to further identify Loyola as a school that enrolls students in grades six through twelve.
Several buildings are on the school's sixty-acre campus.
The main building is Burk Hall, opened in 1996. The departments of Religious Studies, Art, History, Math and Computer Science are located here as are the offices of the Headmaster, College Counselor and Guidance Counselor. The Chapel of Our Lady of Montserrat, with seating for 250 persons, also opened in 1996. Burk Hall and Our Lady's Chapel resulted from an unprecedented collaboration between faculty and alumni who designed and built the structure. The principal benefactors were Henry J. Knott Sr.