There is no data to suggest that using more than one SU at the same time is of any greater benefit than using one. Side effects other than hypoglycemia are rare. Occasionally, chlorpropamide, and more rarely other sulfonylureas, can interact with alcohol to cause vomiting and flushing. There are many sulfonylurea pills available. They are sometimes stronger than first-generation drugs, but mainly have fewer side effects.
Some pills are available as lower-priced generics, others are only available as the branded version.