The purpose of this project is to investigate approaches by which such information could be exploited. Development of methods for measuring the structure of proteomes. These might be based on a mathematical comparison of distance matrices, or by graphical approaches. Work has now begun on developing algorithms for the former approach, comparing prokaryotic organisms on a pairwise basis. Development of graphical visualisation of proteome comparison.
Various tools exist for visualisation of complex information.
Development of a phylogeny based on proteome structure. This represents the 'holy grail' of this project. An interest in protein families, and the relation of protein structure to function, is essential for this project. Some familiarity with computer programming is also required. Any specialist knowledge concerning phylogentic analysis would be welcome but is not essential.