The maximum single IM dose for a dog or a monkey is 3.0 ml for animals greater than 6.0 kg. The maximum single IM dose for swine is 5.0 ml for animals greater than 10.0 kg. A large intramuscular injection into a small muscle mass may force the dose into fascial planes and subcutaneous tissues that may accelerate lymphatic drainage and may also cause pressure necrosis or nerve damage. For studies requiring repeated parenteral dosing, the same site should not be used for two consecutive administrations. In addition to volume of administration, one must also consider the character of the solution.
Volumes listed previously are for maximum daily cumulative administrations.
Foster, H.L., Small, J.D., and Fox, J.G., The Mouse in Biomedical Research , Vol. III, Academic Press, 1983. The Rhesus Monkey , Vol. I, Academic Press, 1975. Methods of Animal Experimentation , Vol.