Therapeutic options are limited.
The pathophysiology of HHT has been suggested to be due to a dysregulation of angiogenesis. Patients maintained a daily diary throughout the study including a two-week observational period prior to treatment. Hemoglobin levels were obtained in all patients with GI bleeding monthly. Urinary genistein levels were measured before SPI and after the first month. Nine patients were enrolled and a tenth took an alternate soy product off protocol.