If there is any possibility at all that your partner may have HIV or another STD, I strongly encourage the use of condoms every time you have sex. Besides STD's, anal sex can have other health concerns as well. There can be physical trauma to either partner during anal sex. This is because there is a lot of friction that occurs during this activity. If either partner finds anal sex too painful or uncomfortable, they may choose not to engage in this activity.
Some people can also have physical reactions to semen during anal sex.
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