Alcohol is high on calories with no real food value. Your blood pressure will also go up, increasing the chance of having a heart attack and some kinds of stroke. You'll also risk liver damage. Other risks faced by long-term, heavy drinkers are cancer , especially cancers of the mouth and throat. If you drink heavily and smoke, you're 150 times more likely to develop throat cancer than people who don't.
Women also risk having problems if they want to become pregnant.
Men and women can develop psychological and emotional problems, including depression and an inability to relate to people properly. And that's nothing to laugh about.