One is BCNU combined with O6BG and the other is CPT-11 combined with Taxol. Either one would be administered at the U of C. BCNU is related to CCNU, which is the pill that Paul took once a month as part of the PCV chemotherapy, and was the primary cause of his low blood counts. O6BG is a drug that is used to help overcome tumor resistance to chemotherapy. They are both given by IV every 6 weeks. The first time he would be in the hospital 2 nights and after that it would be on an out-patient basis.
Side effects are likely to be low blood counts.
This may not actually be a possibility because the first opening that they have is Oct. 22, and Dr. Nicholas doesn't want to wait that long to begin treatment. They have already decided the optimum dose to give, so if Paul got in this one, it would actually be like being in a phase 2 trial. They are both given by IV also. Dr. Nicholas didn't know how often. Side effects are likely to be low blood counts.