A large number of different planets in the Tenth House indicates a person who has many different energies directed towards the goal of success. The Twelfth House is difficult to understand. It is related to anything which is hidden, such as secrets, secret enemies, or people who betray us. It also has a link to hospitals, prisons, or other places of confinement. On a slightly different tack it is related to self-sacrifice, and to subconscious, repressed and unintegrated energies and emotions.
Some astrologers link it to negative karma.
The planets in the Twelfth House show those energies in our psyche which are suppressed, and which we have not yet integrated into our conscious experience. Second, Fifth, Eight, Eleventh. Planets in these indicate that you have stability,willpower and fixity of purpose. Planets in these houses indicate that you are mentally active and communicative in your ideas. These are the First House of energy and vitality, the Fifth House of creativity and offspring, and the Ninth House of learning and conviction.