It's OK to start a new contraceptive if fewer than 13 weeks have passed since the last shot. Depo-Provera may improve PMS, depression and symptoms from endometriosis. Can prevent ectopic pregnancies Unlike combined pills, Depo-Provera is not less effective if you take medicines that affect the liver. Depo-Provera injections can lead to very irregular periods. If your bleeding pattern is bothersome to you, you can take medications which may give you a more acceptable pattern of bleeding.
Some women gain weight.
To avoid weight gain, watch your calories and get lots of exercise. Depo-Provera does not protect you from HIV or other infections. Use condoms if you are at risk. You must return to the clinic every three months for your injection. Depression and premenstrual symptoms may become worse.