This is because of conservation of immunoglobulin sequences between species. The project is my own academic initiative prompted by my research and teaching interests in the field of therapeutic immunology. I intend to develop the project and publish the results on these web pages in a way which makes the data transparent to the reader and thus of use to the wider academic community. This project will be updated and continued as and when I can find time from my other teaching and research duties. I intend to work only from therapeutic antibody sequences which are publically available and thus verifiable.
Suitable sources are the scientific literature and published patents.
Hopefully most sequences will be in electronic format and easily downloaded from the main databases. After obtaining the sequences my initial analysis will be to quickly identify the Variable region sequences of the antibodies by reference to the immunoglobulin sequences from the Kabat and the IMGT databases and using the alignment resources from Andrew Martin . This resource also gives an indication of how common these different germline genes are in the human population. I plan to identify homologies for VH and JH segments and also for VK and JK or VL and JL separately. At present I plan to ignore identification of the the DH region sequence which contributes to the heavy chain CDR3.