It recommends that you perform each in order, if you use it at all. This may be an excellent and safe utility, but I recommend a verified backup of all critical applications and data immediately before using this function. There are some times, however, that the registry is causing problems and needs to be disciplined. The Wizard is your man. Before you go any further, backup your registry.
Some additional choices are available under the advanced button.
Click finish and a bell sounds when things are done. Repair says it will deal with registry entries for files that have been moved or no longer exit. You can look at the advanced screen, but I didn't feel confident changing anything there. Click on repair all, next. After some more disk activity, a highlighted list of files appears with a caption of blank out of blank orphans found.