Chronic exposure to rats has resulted in renal papillary necrosis, renal pelvic hyperplasia and atypia. Use of acetylsalicylic acid has been correlated with increased risk of renal cancer in humans. See information on salicylates. Additional effects include platelet dysfunction, hypoprothrombinemia, thrombocytopenia, hypoglycemia, and hypokalemia. Hypersensitivity reactions resulting in angioneurotic edema, hives, laryngeal edema, urticaria, rhinitis, asthma, asphyxia, and shock.
Some salicylates alter prostaglandin synthesis.
In addition to the effects from acute exposure, irritation with gastric perforation and mucosal injury, hematemesis, diarrhea, melena, gastrointestinal hemorrhages, gastric ulcers, and pyloric spasms have been reported. May cause abnormal retinal bleeding, papilledema, dimness of vision and skin reactions including eruptions, petachiae, and ecchymoses. Other effects include headache, deafness, thirst, confusion, restlessness, incoordination, drowsiness, faintness, and psychosis. Some salicylates may cause blood effects including prolongation of bleeding time, leukopenia, pancytopenia, shortened erythrocyte survival time, acute intravascular hemolysis, and anemia. Hypoxia, hypocapnia, decreased plasma iron concentration, hypertension or hypotension, increased heart rate, movement disorders, vasomotor depression and anorexia have been reported.