Our laboratory is interested in utilizing immunologic and molecular techniques to investigate prostate cancer. In this funded project, we are examining a transgenic mouse model developed by Dr. Norman Greenberg which was developed by linking SV40 T antigen to the rat probasin promoter. RWVs are bioreactors which rotate at low speeds and simulate microgravity conditions. It is hypothesized that this environment, in which three-dimensional growth is possible, may better simulate in vivo growth. Examination of members of the TNF receptor family and their role in apoptosis in human prostate cancer.
Several proposals are currently under review.