It strongly inhibits the reuptake of both serotonin and norepinephrine. Before taking action, whether the sexual dysfunction is a result of the antidepressant or the under-lying depression must be clarified. Treatments that may be considered include neostigmine, cyproheptadine, and yohimbine. Many antidepressants are prone to induce this symptom. Sedation often diminishes in the first weeks of treatment, and persons experiencing only minor difficulty from this side effect should be encouraged to allow some time to pass before changing antidepressant agents, all other factors being equal.
Some patients tolerate their medication better when it is given as a single dose before bedtime.
While MAO inhibitors are not anticholinergic, their side effects may resemble anticholinergic symptoms. The most common undesirable consequences of cholinergic blockade are dry mouth, impaired ability to focus at close range, constipation, and urinary hesitation. Buproprion, fluoxetine, sertraline, and trazodone do not usually induce weight gain. Psychotherapy In general, psychiatrists agree that severely depressed persons do best with a combination of medications and psychotherapy. Medications relieve the symptoms of depression quickly, while psychotherapy can help the person deal with the illness and ease some of the potential stresses that can trigger or exacerbate the illness.