Pre-existing need for aspirin following coronary artery bypass grafting, percutaneous transluminal coronary angioplasty, or carotid endarterectomy. Low doses of aspirin and warfarin to reduce the risk of a second heart attack. Hypersensitivity to salicylates. Clients with asthma, hay fever, or nasal polyps have a higher incidence of hypersensitivity reactions. Severe anemia, history of blood coagulation defects, in conjunction with anticoagulant therapy.
Salicylates can cause congestive failure when taken in the large doses used for rheumatic diseases.
In pregnancy, especially the last trimester as the drug may cause problems in the newborn child or complications during delivery. In children or teenagers with chicken-pox or flu due to possibility of development of Reye's syndrome. Also, controlled-release products are not recommended for children less than 12 years of age and in children with fever accompanied by dehydration. The toxic effects of the salicylates are dose-related. Bronchospasm, asthma-like symptoms, anaphylaxis skin rashes, angioedema, urticaria, rhinitis, nasal polyps.