After an incubation period of 3 to 5 days, the infection results in flat small blisters on the hands and feet, and oral ulcers. These are sometimes painful, so the child eats little and frets. There may be a mild fever. Sometimes in young children there is a rash on the buttocks. Blisters on an infant's foot After a few days the blisters and mouth ulcers settle leaving no scars.
Second infections are rare.
Specific treatment is not necessary. Antiseptic mouth washes and simple analgesics such as paracetamol relieve the discomfort of eating.