In contrast, LSD is a man-made substance, first developed by a legitimate pharmaceutical company in 1938. Today, most hallucinogens are used experimentally rather than on a regular basis, with only single or several uses per year reported by most users. LSD is an extremely potent hallucinogen with only minuscule doses required to produce effects. Such experiences typically occur during times of increased stress and tend to decrease in frequency and intensity if the individual abstains from use of the drugs. The abuse of cocaine has strikingly increased in recent years.
Smoking produces an instant and intense euphoria attractive to abusers.
Other effects include local anesthesia, potent CNS stimulation, feelings of increased confidence, energy, accompanied with decreased inhibitions. Both tolerance and dependence may occur with chronic use of cocaine. The drug is considered both physically and psychologically addicting. Regular users may exhibit mood swings, depression , sleep problems, memory loss , social withdrawal, and loss of interest in school, work, family, and friends. Amphetamines During the 1950s through 1960s, amphetamines were commonly prescribed for conditions such as fatigue , obesity , and mild depression.