Higher doses produce a withdrawn catatonic state, ataxia, dysarthria, muscular hypertonicity, and myoclonic jerks. Unusual rotatory and vertical nystagmus is often present and aids in the diagnosis. Cardiovascular status is usually unaffected. Prolonged psychotic states are reported to occur after PCP use. Treatment Diazepam 10 to 20 mg po often helps diminish anxiety and is mandatory when seizures occur.
Some clinicians believe that haloperidol is useful.
Hypotension may occur when chlorpromazine is used. Diazoxide may be used when severe hypertension is present. PCP is highly lipid-soluble, and it and its metabolites may remain in the CNS for long periods. Because PCP in solution is alkaline, large amounts of it are secreted into the stomach and have been recovered with prolonged gastric lavage. All rights reserved.