Ipriflavone, another isoflavone, slows bone reabsorption and stimulates Collagen synthesis in bone. Work in Finland has found a significant inverse relationship between isoflavone intake and coronary heart disease in both women and men. A similar study in male health professionals in the United States has not demonstrated any statistically significant correlation between coronary diseases rates and isoflavone intake. However, a recent meta-analysis found that high soy intake correlates well with an improved lipid profile in the United States population. As yet there have been no interventional studies published on the impact of isoflavones on menopausal symptoms such as hot flashes, dyspareunia, and vaginal dryness.
Several trials are currently in progress.
Foods rich in phytoestrogens have benefits that range far beyond the treatment of menopausal symptoms. Soy products are an excellent source of plant proteins, and their use as a substitute for red meat in the diet may provide considerable improvement in lipid profile and cardiac risk. If they prove to ameliorate menopausal symptoms and mitigate cardiac and cancer risks, health professionals should actively advocate their increased consumption. Yams, to have a significant biologic effect, need to be eaten raw and in huge quantities, and are not a viable source of hormonal supplementation. Alternatives to Conventional Hormone Replacement Therapy Valente M, Bufalino, L Castiglione GN, et al.