The nation's leading supporter of biomedical research on disorders of the brain and nervous system. Symptoms of HSP may occur alone or, in more complicated forms of HSP, may occur in combination with a number of other neurological symptoms. Generally, the primary feature is severe, progressive, lower extremity spasticity. There is no specific treatment to prevent, slow, or reverse HSP's progressive disability.
Treatment is symptomatic.
The prognosis for individuals with HSP varies greatly. Some cases are seriously disabling while others are less disabling and are compatible with a productive and full life. The majority of individuals with HSP have a normal life expectancy. The goals of these studies are to increase scientific understanding of these disorders and to find ways to prevent, treat, and cure them. Advances in hereditary spastic paraplegia Current Opinion in Neurology.