In particular, eliminate places where mice can find shelter. They cannot survive in large numbers if they have few places to rest, hide, or build nests and raise their young. Total elimination of mice through sanitation, however, is almost impossible. Mice can survive in small areas with limited amounts of food and shelter. Mouse-proof construction is the most successful and permanent form of house mouse control.
Steel wool makes a good temporary plug.
Seal cracks in building foundations and openings for water pipes, vents, and utilities with metal or concrete. Doors, windows and screens should fit tightly. Cover the edges of doors and windows with metal to prevent gnawing. Latex, plastic, rubber, wood, or other gnawable materials are unsuitable for plugging holes used by mice. Trapping is an effective control method for controlling house mice.