You want to tackle something that requires a little more thought on your part. InDesign gives you two options for automatic kerning, metrics and optical. Basically, the spacing between character pairs is predefined by the font. Metrics kerning relies on that font-provided information.
Some fonts contain information for a large number of kern pairs.
Other fonts offer only limited support, and in that instance, the metrics kerning won't really affect the character spacing. In the second You, the o is placed closer to the Y, resulting in a smoother appearance. You don't have to worry about whether the font you choose has 30 kern pairs or 300, because those predefined pairs are not needed when optical kerning is selected. It' s easy to switch between the two types of automatic kerning. Go to the Character palette and select the Kerning menu.