This rapid emergence and development allows hemp dogbane to compete strongly with row crops. Corn withstands hemp dogbane competition better than sorghum or soybeans. An alfalfa stand cut three times a year for three years will substantially reduce stands of hemp dogbane. Competition from alfalfa and the frequent cuttings deplete the weed's root system. Including winter wheat in a crop rotation helps control hemp dogbane.
Winter wheat grows rapidly in the fall and early spring when hemp dogbane is inactive.
Periodic summer tillage after harvest and before wheat seeding further weakens the weed. A single winter wheat crop will not eliminate hemp dogbane, but will reduce infestations. Preventing seedling establishment is an important part of controlling hemp dogbane. Cultivation or an application of 2,4-D will control hemp dogbane during the seedling stages. It is much more difficult to control after buds have developed on the roots.