Theophylline distributes in all body compartments.
Liver is the primary site of metabolism. Therefore, the optimum therapeutic maintenance dose should be determined by individual titration. Slo-Bid is a controlled release formulation which produces peak blood levels between 5 and 8 hours post dose. Once the steady state has been achieved, therapeutic blood levels persist for 12 hours in most adult patients. For the symptomatic treatment of reversible bronchoconstriction associated with bronchial asthma, chronic obstructive pulmonary emphysema, chronic bronchitis, and related bronchospastic disorders.