Each page is initially copied from a master template page which has the header and footer areas, but not much body text. Hopefully, no horizontal scrolling is required. Of course vertical scrolling is to be expected, although I have tried to minimize it on the main page. I use a consistent color scheme of blue with red highlights. The text is black on white, because that provides the most contrast and works well on high resolution monitors.
Unvisited links are red so they stand out, and visited links are blue to blend in.
No doubt you've noticed that this site uses tables to provide a consistent layout grid. Tables work very well for this, but they have the unfortunate side effect of leaving areas of the screen blank until the entire table is loaded. To help solve this, the pages are broken up into several smaller tables for the header, the body area, and the footer. If the body is a bit long I break it up into several tables, usually at the sub-headings. See my CA-Clipper Coding Guidelines page for an example.