Viral infection is typical of other cell associated herpes viruses.
Cell free enveloped virions enter susceptible cells by convention absorption and penetration. Cell to cell transfer of infection via formation of intracellular bridges is the principle mode of virus spread. There are three types of virus cell interaction. Productive Infections Productive infections are those in which the replication of viral DNA occurs, antigens are produced and virus particles are synthesized. There may be more than 1200 particles produced per infected cell.