Menadione A form of vitamin K 2 . It is water-soluble which causes high toxicity. It used to be used in infant formulas, which caused an increase in hemorrhagic disease of the newborn. It is NOT used any more. It also causes liver damage and anemia from high doses of vitamin K 2 .
Vitamin E antagonizes vitamin K and causes hypersensitivity to coumarin anticoagulant drugs.
With megadoses of vitamin E, the PT increases. With megadoses of vitamin E, it worsens clotting defects in vitamin K deficiencies. Biological Activity Vitamin E seems to have anti-oxidant activity, i.e., it protects lipids in membranes from forming highly reactive peroxides. These would destroy the membrane and, hence, the function of the cell or cells. Absorption, Transport and Storage Absorption is dependent on same as the other three fat-soluble vitamins.