The largest enterprises are concentrated in Kazlu-Ruda and Kalvarija, though are a lot of enterprises in other places too. Since ancient times, the district has been famous for its high agricultural development. The district of Marijampole has deep and ancient traditions of amateur art and ethnic culture. There are over 150 schools, a seminary for teachers, the Marianen gymnasium, the Rygiskiu Jonas gymnasium and several agricultural colleges. Festivals of the arts, with local orchestras, as well as amateur theatricals, are held by Lake Orija.
Tourism is developed.
The town of Marijampole is the administrative centre of the district. The Town Board and Town Council are the administrators. The district is divided into 10 offices called seniunija. The municipality of Marijampole is on friendly terms with the officials of T ringen in Kyff-hauser, Germany. The municipality is seeking investments for the modernization of the municipal economy, and the protection of the environment.