Once glued to the placental cell, it sprays Tumor Necrosis Factor on the cell and kills it. Natural Killer Cells are activated by a pregnancy that fails or a fertilized embryo that degenerates. They produce large quantities of Tumor Necrosis Factor locally that kills the placental cells and the fetal cells. When the levels are this high entering into a cycle of conception, it is recommended that IVIg be administered on day 7,8 and 9 of that cycle. It is not true that the numbers always come down with treatments.
Some patients become professional number counters.
This will make you crazy if you expect the numbers to come down, and they do not. This test determines the amount of IVIg to be given. The Natural Killer research test simply separates NK cells from the patient and asks them to perform their aggressive roles in the test tube. We then add varying concentrations of IVIg to the test tube to determine how much is necessary to prevent killing. They may rarely elevate in women with miscarriage and infertility.