For a humanities major, just about everything. The problem for the humanist is not the questions so much as the answers. Science has as its goal the discovery of these explanations. The sciences exist to examine the phenomena of nature.
Scientists begin their work by forming a question, or hypothesis, about the phenomena of nature.
They then devise an experiment that they hope will measure the behavior of the phenomenon in question. Scientists understand that many things might influence an event. Scientists understand that even the misses are worth investigating and reporting, because they can rule out certain hypotheses, thereby taking the sciences one step closer to the truth. Truth in the sciences is crafted out of fact. She tests them.