Tolerance develops to the respiratory depressant, sedative, analgesic, emetic and euphorigenic effect. Injecting can be a risky business in prohibitionist society. This is because hygiene is difficult, education is minimal, and fluctuations in quality can lead to accidental overdose. The teeth have rotted out, the appetite is lost, and the stomach and intestines don't function properly. Good traits of character disappear and bad ones emerge.
Sex organs become affected.
Veins collapse and livid purplish scars remain. Imaginary and fantastic fears blight the mind and sometimes complete insanity results. Heroin is sometimes smoked with crack cocaine. This is an even more intensely rewarding experience than taking either drug alone. Yet in a clinical setting and among the terminally ill, the simultaneous use of cocaine, methylphenidate or amphetamines with heroin or morphine can augment the opioid's analgesic and anxiolytic effect while allowing its dosage to be lowered.