The only negative aspect of a single deck game is that it generally draws more attention from pit bosses because they know card counters can beat single deck games more readily compared to multiple deck games. The first thing you must do is evaluate the rules of the single deck game because some games have good rules and other not so good. The best rules allow unrestricted doubling or replace the double down rule with resplitting of aces. As a general rule, you'll find more single deck games with favorable rules in Las Vegas than elsewhere. Another very important variable that determines whether a single deck game is worth your time is the penetration or percentage of cards that are dealt from the deck prior to the shuffle.
Some casinos offer single deck games but shuffle after one or two rounds.
Forget these games. The more cards that you see prior to the shuffle, the greater will be your advantage with card counting. This is very important so shop around for the best penetration. You also do not want to play single deck games at a crowded table. The reason you want to play at un-crowded tables is that you'll be getting more hands between shuffles and getting down more bets per unit of time compared to a crowded table.