Demonstrated that epidemiological and experimental human data do not support that arsenic methylation protects from low dose effects. Identified a dose-response relationship between arsenic exposure and bladder cell micronuclei, a genotoxic marker of effect. Identified a preliminary dose-response relationship between arsenic concentration in well water in India and the occurrence of keratoses and hyperpigmentation. Studies currently underway in India, Chile and the US , will allow projection of cancer risks with individual exposure data.
Studies are currently underway to identify nutritional and genetic suceptibility to arsenic effects.