However, such surgery is especially challenging because of the delicate nature of the retina. In collaboration with Dr. Jorge Arroyo , he is developing new surgical techniques to remove scar tissue caused by AMD and to repair retinal detachments that often result when diabetic retinopathy goes untreated. Drug treatments may become a powerful weapon in the fight against AMD and diabetic retinopathy. They are now working with pharmaceutical companies testing drugs to block VEGF and to prevent these blood vessels from forming. In addition to looking for a VEGF inhibitor, these physician-scientists are exploring new ways of delivering drugs to the retina which would offer both greater effectiveness, and protection from side effects.
Some evidence exists that macular degeneration is, in part, an inherited disease.
In collaboration with investigators at three other institutions, they are applying new strategies to the search for additional genes. Dr. Seddon's team of researchers has also demonstrated that cigarette smoking contributes to the development of AMD, and that diets rich in antioxidants may be beneficial in slowing or stopping its progression. The Institute hopes to accelerate the pace of discovery by recruiting additional retina experts to work with the Infirmary's highly respected team of physician-investigators on these and other pioneering research initiatives. Eight thousand square feet of new laboratory space, equipped with the latest technology, will be renovated to accommodate approximately 12 Retina Research Institute physician-investigators and scientists. A key member of the Institute's team will be a senior faculty investigator with expertise in the molecular biology and biochemistry of the retina.