Often, when you are afflicted by a strange, recurring problem, or when you can't find a special encounter that the hint book tells you is there, you need to reinstall the game. This helps more often that you might think. Unfortunately, sound and display drivers can become corrupted or out of date. Contact your computer's manufacturer or go to their web site and get the most up to date drivers. Reinstallation of the game and the latest sounds and display drivers fix the vast majority of strange problems.
Sound effects are one of the most common causes of problems.
Turn off sounds in the Preferences window. If a Character or Scenario Editor was running at the same time as the game, this can cause problems. Quite both programs, and run the game again. In the Exile games, if you get crashes while targeting a spell, select No Targeting Line from the Preferences. Tragically, this feature was left out of v1.0 of Blades of Exile for Windows.