Hydrocarbon insecticides can be carcinogenic and teratogenic and are well absorbed through the skin and GI tract. DDT affects neuronal conduction by lengthening the time that the sodium channel is open. It also appears to alter the metabolism of acetylcholine, norepinephrine, and serotonin. Organochlorine poisoning accounts for only a small fraction of pesticide poisoning. In the US, fatalities are limited.
Toxic doses are variable and reports of poisonings are limited.
There may be an initial euphoria with auditory or visual hallucination and perceptual disturbances. Due to the high lipid solubility, the duration of toxicity can be prolonged. Life-threatening complications are secondary to seizures and respiratory effects of CNS stimulation. Gastrointestinal and dermal decontamination are a priority. Charcoal is helpful for gastrointestinal decontamination.