Examples of hereditary disorders include hereditary hemorrhagic telangiectasia, Ehlers-Danlos syndrome, Marfan's syndrome, osteogenesis imperfecta, pseudoxanthoma elasticum, and homocystinurea. Acquired vascular disorders result from insults to the vascular blood interface. Examples of these include malignant paraprotein disorders, amyloidosis, lupus, scleroderma, rheumatoid arthritis, Cushing's syndrome. Platelet disorders are characterized by petechiae, purpura, mucosal membrane bleeding, and bruisibility. Examples of congenital platelet disorders include Thrombocytopenia absent radius syndrome, Amegkaryocytic Thrombocytopenia, Glanzmann's Thrombasthenia and Bernard-Soulier Syndrome.
Viral infections are a common cause of immune and infectious thrombocytopenia.
Aspirin and other cyclooxygenase inhibitors are the most common cause of drug induced platelet dysfunction. A potent stimulator of platelet activation. Hemophilia A and von Willebrand's Disease are the most common congenital coagulation disorders and both involve different components of factor VIII macromolecule. VW resulting in impaired platelet adhesion. This disorder is inherited as a autosomal dominant and is characterized by bleeding from mucocutaneous surfaces.