If you are driving to Kasane from the south you must fill at Francistown and Nata, or Gaborone, Kang and Maun, and in between. If driving from Vic' Falls it is only 80 - 90 km to Kasane where you can fill. Most of the National Park areas are unfenced and thus game can often be seen crossing roads. Be especially aware of elephant and warthog near dusk and during the evening. Road laws in Botswana are strictly enforced.
Seat belts are compulsory.
Ensure that your vehicle is licenced and that you have the paperwork from the border control to show it is taxed for Botswana for the period of your stay in Botswana. Fire is a major hazzard in Botswana during late August and September at the end of the dry season - exercise caution. Advance booking through your national AVIS central bookings or the Internet is required. AVIS say they will move cars to the Mowana station at no extra charge. They do not like you taking their cars across borders.