In addition, patients and families should monitor the patient's degree of weight gain while on mirtazapine to ensure that it does not become excessive. Management of Overdose Another advantage of mirtazapine in the adolescent population is the minimal risk of toxicity with an overdose. Although there is still only limited experience with mirtazapine overdoses, all patients reported have experienced a full recovery. Signs and symptoms associated with overdosage include sedation, disorientation, and tachycardia. At this time, there are no reports of mirtazapine causing other arrhythmias, seizures, or coma.
Treatment is supportive.
Patient management should include a careful history to identify a multiple-drug ingestion which might include a more toxic agent. Dosing Recommendations Mirtazapine is marketed as Remeron by Organon. The 15 and 30 mg tablets are scored for dose titration. The recommended starting dose for adults is 15 mg per day in a single dose. This dose is usually given at bedtime to avoid excessive daytime sedation.