Or maybe it just involves a lot of talking about drug abuse and casual sex. It's hard to tell. If you think all of this sounds weird, you should see how it looks. House of Leaves is a virtual encyclopedia of typographical gimmicks and stunts. Extensive passages appear with a line through them, or are crossed out to indicate Zampano's efforts to burn or obliterate the text.
Whole chapters are nothing but commentary and exegesis.
Looked at from this angle, the hero of the story is Johnny Truant. Small comfort, that. Most recent experimental fiction is characterized by obsessive inwardness and irony. But it might indicate a small progression too. Indeed, to be truly postmodern it should provide as many different explications as possible.