This is spoken metaphorically. Were it only an angel, we should not grieve him, much less the Spirit of God. A sinner tramples upon God's law, crosses his will, does all he can to affront, yea, to spite God. Sin would not only unthrone God, but un-God him. If the sinner could help it, God would no longer be God.
Sin is an act of disingenuity and unkindness.
Some are sick of pride, others of lust, others of envy. It is with a sinner as with a sick patient, his palate is distempered, the sweetest things taste bitter to him. This is a disease, and nothing can cure this disease but the blood of the Physician. It makes a man act not only wickedly, but foolishly. As Lysimachus, who, for a draught of water, lost a kingdom.