You may discover a great deal from their answer to this question. People rarely expect such a question in a professional interview and you see a bit of the real person. Ask about long hours. Watch and observe their response. Talk about skills.
Skills are important, but skills can be taught or enhanced.
It is the intangibles of character, of adaptability, and of work ethic that generate success. Ask candidates what management style they find most productive for themselves. Certainly if they respond that they can't stand being micro-managed you have a key that they may or may not fit into the environment or culture that you have to offer. A key to a good interview is to create silences that the candidate has to fill. Brief questions, with no annotation, are extremely effective.