There are no adequate and well-controlled studies in pregnant women. Gadodiamide should be used during pregnancy only if the potential benefit justifies the potential risk to the fetus. Because many drugs are excreted in human milk, caution should be exercised when gadodiamide is administered to a nursing woman. No specific precautions other than those pertinent to MRI and gadodiamide in general are applicable for elderly patients. The majority of these adverse reactions were of mild to moderate intensity.
Treatment is symptomatic.
There is no antidote for this contrast medium. In patients with delayed elimination due to renal insufficiency and in patients who have received excessive doses, the contrast medium may theoretically be eliminated by hemodialysis. If nondisposable equipment is used, scrupulous care should be taken to prevent residual contamination with traces of cleansing agents. Contrast-enhanced MRI should start shortly after administration of the contrast medium. Optimal enhancement is generally observed within 45 minutes after injection of gadodiamide.