At the present time, there is no cure for Sanfilippo syndrome. Enzyme replacement therapy and gene therapy are the two treatments that researchers have been focusing on to eventually cure Sanfilippo syndrome and other MPS diseases. There are a number of research institutions around the world working on finding a cure for the MPS diseases including facilities in the United States, Canada, England, and Australia. What to Expect Sanfilippo syndrome is a progressive disorder, however, the rate at which the children deteriorate varies from one individual to another. In stage 2, the child may become extremely active, restless, and often have very difficult behavior.
Some children have sleep disturbances.
Many like to chew on their hands, clothes, or other accessible items. Language and understanding will gradually become lost. Some children never become toilet trained and those who do will eventually lose the ability. In stage 3, the child will begin to slow down. They have more difficulty when walking or running and fall often, eventually losing the ability to walk altogether.