It is okay to start a new contraceptive if it less than 13 weeks since last shot. May lead to improvement in PMS, depression or symptom from endometriosis. Good for women who cannot use estrogen-containing contraceptives. Disadvantages Depo-Provera injections can lead to very irregular periods, or your period may stop altogether. If your bleeding pattern is bothersome to you, there are medications which can be given to you which may make you have a more acceptable pattern of bleeding.
Some women gain weight.
To avoid weight gain, watch your calories and get lots of exercise. You have to return every three months for your injection. Depression and premenstrual symptoms may improve or become worse. It may be a number of months before your periods return to normal after your last shot. It may be four months to two years before your fertility returns to normal after your last shot.