There are possible elevations in blood fat, triglycerides, and possible abnormalities in liver function tests, which I have seen personally. Stopping Accutane reverses these. There are a number of minor side effects with Accutane. Nearly everyone has dry skin and especially dry lips. Some people have dry eyes, and cannot wear contacts during their course of Accutane.
Some people have sun sensitivity.
Some complain of aching joints and muscles. A few complain of hair loss, but this is unusual in my experience. There are extremely rare cases of night blindness which have been reported. That absolutely demands to be made clear, and I hope that future studies make this clear. But it doesn't affect sex drive that we know of.