To that end, we have developed two collaborative projects with clinicians at Emory. The goal of one project is to develop methods for transplantation of encapsulated, xenogeneic islets for the treatment of diabetes. The second project is to develop techniques for transplanting allogeneic, retinal pigmented epithelial cells to treat macular degeneration, the leading cause of blindness in people over the age of 65. Exogenous antigen gains access to the MHC class I processing pathway in B cells by receptor-mediated uptake. J Exp Med.
T lymphocytes regulate the induction and maintenance of oral tolerance.
CTLA4-Ig prolongs survival of microencapsulated neonatal porcine islet xenografts in diabetic NOD mice. Antigen is required for activation but not for maintenance of cytotoxic T lymphocytes. J Exp Med. The role of TCR Bearing T cells in oral tolerance. Opium alkaloid noscapine is an anti-tumor agent that arrests metaphase and induces apoptosis in dividing cells.