Simply stated, TAD is a molecular weapon designed to confront the AIDS pandemic head-on. Second, the Defensins have been selected through Evolution to kill cells by penetrating biological membranes, and attacking chromatin. When drugs are administered that only partially inhibit HIV-1 replication, the resulting evolutionary pressure selects for resistant strains. The potency of TAD would provide the lowest rate of production of resistant genotypes. Additionally, proactive and reactive switching or a TCM approach to therapeutic application may provide significant protection from resistance.
TAD enters the cell, following delivery by an appropriate vector .
Rev exports unspliced mRNA having both RRE and introns. Since the Defensin is translated in the absence of the protective propiece peptide, the toxin bores into the inner nuclear membrane and destroys heterochromatin. The translation of the toxin into the ER lumen is the essential biosynthetic pathway for Defensin peptides, albeit the protective shell is present during the transit to the Phagocytic granules. The increate presentation is not intended to be a pretentious commercial advertisement. TAD is merely a theory, and the site is designed for the Research and Medical Scientist audience.