Introduction to toxicology covering basic principles, dose-response, toxicity testing, chemical metabolism, mechanisms of toxicity, carcinogenesis, interpretation of toxicological data for risk assessment and target organ toxicity. Current topics in research on chemical effects on biological systems. May be repeated for credit. This course provides a quantitative framework for estimating exposure and dose to occupational and environmental toxicants. Statistical theory is applied to describing exposure variability over time, and to organizing efficient exposure monitoring programs.
Statistical issues involving simultaneous exposure to multiple toxicants are also explored.
Mathematical theory is applied to the prospective and retrospective estimation of exposure intensity. The same theory is applied to physiologically-based pharmacokinetic modeling and estimation of the dose received at target tissue sites in the body. 270B, 254A or equivalent course recommended, or consent of instructor. The purpose of this course is to teach the skills of quantitative risk assessment by means of lectures and a group risk assessment project. This course provides students the opportunity to learn in detail how these fields are integrated within the process of quantitative risk assessment.