If you let your personal life dictate your business activities you might not have a business to worry about. Everyone needs to understand that there are times when you are not be disturbed. This might mean a closed door or some sort of signal. One person I know has a special hat that he wears when he wants to let his family know that the do not disturb sign is out. Decide when your body clock is at its optimum.
Some people are more productive in early morning, others late at night.
Find out when you do your best work and then schedule that time for office hours. Again for home-based businesses, don't let neighbors steal your time or ask you to do them favors because you just happen to be home during the day. This can become a real time thief if you allow friends and family to think that you're running a business out of your home means that you are available to drop everything for a cup of coffee or to do them a favor. And if you office outside the home, be careful of those corporate-world buddies wanting you to get together for lunch, take an afternoon for golf or just chat on the phone. While their boss still pays them to buddy around, most likely those times can cost you big time in lost income dollars.