In fact, most dentists and hygienists will advise patients to remove their dentures overnight. This gives the soft oral tissues time to recover from the friction or irritation that dentures may cause. Also, the dentures and the underlying tissue should be thoroughly cleaned every day. From your description above, I suspect you may have denture stomatitis. Denture stomatitis, also called denture sore mouth or chronic atrophic candidiasis, occurs in approximately 65 percent of patients who wear complete upper dentures.
Women seem to be more susceptible than men.
Poor fit, poor relationship of upper and lower teeth, and failure to remove the appliance at night can all contribute to this condition. The clinical appearance can vary somewhat, although it is typically bright red with a velvety to pebbly surface. White patches may also be evident. Removing the source of the infection may be as simple as removing and cleaning the appliance nightly. Cleaning the denture with antifungal cleanser may be helpful.