But this could reflect problems in Brodmann s classification. Afterall, he did that work almost 100 years ago. Cytochrome oxidase is an enzyme used in metabolism. In recent years, have observed particular patterning in visual cortex when stain for cytochrome oxidase. Sure enough cytochrome oxidase shows clear differences between functional visual areas.
Supports hypothesis that functional areas correspond to differences in cytoarchitecture.
Some connections easily visible with naked eye, e.g., visual pathway from eye to V1 Association bundles Each of the major white matter bundles is called a fasciculus. Then sacrifice animal and stain for the tracer. Because of the injection site, only certain cell types in a certain retinal location get stained. Some go to parietal lobe and some go to temporal lobe. Clinical observations have provided us with most info on this.