It's also a major problem in Europe and many other parts of the world. Approximately 4 million Americans are infected with this virus, which is currently the leading cause of liver transplants. Many people who have Hep C have had it for over 20 years before finding out.
Some folks have no symptoms at all.
Others have severe fatigue and signs of immune activation similar to those of Chronic Fatigue Syndrome. This includes plasma, shots or IV infusion of gamma globulin, and treatment with clotting factors. Needle sticks are the most likely route, but anyone providing bedside care can potentially have blood exposure through cuts or chapped skin. Persons who have unexplained abnormalities in liver function tests. Sometimes a pregnant woman who is infected can pass the virus to the fetus.