Properties considered include compositional biases, clusters and runs of charge and other amino acid types, different kinds and extents of repetitive structures, locally periodic motifs, and anomalous spacings between identical residue types. Statistically significant sequence features highlighted by SAPS in the input sequence may suggest promising regions for experimental investigation. The program also finds application in the description of conserved features of families of proteins, as well as in the inverse problem of deriving protein groupings based upon sequence features.
Short sequences are subject to larger statistical fluctuations than longer sequences.
The statistical evaluations of SAPS are reliable only for sequences of at least about 200 residues. For the most recent version of the software, please contact supplier .