This causes paralysis which is morphologically correlated to a severe demyelination of the peripheral nervous system. Northern blots for mRNA encoding P 0 protein, the major protein component of peripheral nervous system myelin, show that collapse of the myelin sheath is secondary to downregulation of this and other genes coding for components of myelin. The upregulation of mRNA for P 0 protein after the 9 th day correlates with remyelination by these newly formed Schwann cells. Thus, molecular biological approaches give insight into the pathophysiology of neurological disorders. .
Tellurium causes dose-dependent coordinate downregulation of myelin gene expression.
Control of cholesterol biosynthesis in Schwann cells. Gene expression in brain during cuprizone-induced demyelination and remyelination. Myelin formation, structure, and biochemistry. Raven Press, pgs.