SC Highway 93 is four lanes adjacent to and through the University campus, between Perimeter Road and US Highway 76. From US 76 to US 123, SC 93 is two-lanes, but is slated to be expanded to at least five lanes by the SC Department of Transportation. SC 93 from US 123 to Central city limits already has been expanded to five lanes. The automobile is the predominate mode of travel in Clemson, followed by bicycle and pedestrian travel. Shuttle services exist for some human agency programs and for the Downs retirement community.
Some apartment complexes provide shuttle service to the university on a regular schedule.
In addition, the City operates a shuttle system which transports commuters from remote campus parking lots to shuttle stops around campus. Expansion along this stretch of Highway 93 accounts for increased traffic counts and also may have something to do with fluctuations along Berkeley Drive in recent years. Rail service is provided to the area by Norfolk and Southern Railways and a subsidary of the National Railway Utilization Corporation called the Pickens Railroad Company. In addition, there are 47 authorized motor carriers servicing the County. The area is served primarily by three aviation facilities, Greenville-Spartanburg Jetport located 45 miles away, Anderson County Airport 18 miles away, and the Oconee County Airport located within a mile of the City's western boundary.