Set your mouse speed at about the middle range. Reduce the time spent using the click and drag feature of the mouse as this puts strain on the forearm and hand. Software is available which will convert an extra mouse button to one which performs the click and drag function, or the double click function. Newer computer furniture makes specific allowances for mouse position. Alternatives to a mouse are increasing with the advancement of technology.
Trackballs are a common alternative.
They should have a minimum diameter of 7.5 cm. As well, gliding touch pads are available which are activated by the movements of the finger. The advantages and disadvantages of these various input devices have not been well studied, and should be experimented with before purchase. Wrist Support Foam pads placed in front of the keyboard known as wrist supports remove sharp, uncomfortable edges. These are recommended for frequent VDT users.