Abstract Leukaemia inhibitory factor is a pleiotropic cytokine required for blastocyst implantation in mice. Uterine expression of LIF and that of its receptors have been demonstrated in a number of mammalian species indicating that it may have widespread importance in the establishment of pregnancy. The variations in the reaction of the uterus in preparation for and during implantation is considerable between species and understanding the differences and similarities assists in the interpretation of how this cytokine functions. Recent studies suggest that reduced endometrial leukaemia inhibitory factor contributes to human infertility.
Studies also demonstrate a potential role in placentation and fetal development.
Thus, leukaemia inhibitory factor has become an important cytokine warranting further investigation in the human. It is anticipated that when the mechanisms underlying normal embryonic and endometrial development are elucidated, fertility and infertility will be more precisely understood and hence able to be effectively controlled. If you have not previously downloaded PDF files we suggest you access our Advice page for further information. Journal of Endocrinology Return to the Contents List - Vol.