The endothelial-cell receptor to which the GP binds has not yet been identified. The glycoprotein might not always be necessary to cause severe symptoms. Results from the Reston-infected monkeys indicate that there was less endothelial cell involvement with the Reston subtype than with other Ebola subtypes. Sudden onset of fever and malaise, with extreme prostration and weight loss. Excessive effusions from internal organs occurs, followed by pulmonary interstitial edema and renal dysfunction.
Some patients become jaundiced.
Within 7 to 10 days, patients who will survive begin to recover. Recovery can take 5 weeks or more, and is marked by prostration, weight loss, and amnesia for the period of acute illness. Patients who are at greatest risk of dying experience diffuse or extensive hemorrhage into the skin, mucous membranes, and internal organs, including the cavities of the stomach and intestines. Swelling of the spleen, lymph nodes, kidneys, and brain occurs. In addition, there is usually evidence of interstitial pneumonia and sometimes of pancreatitis and inflammation in the eyes.