My work focuses on the statistical identification of major genes which impact on the expression of common diseases. Most recently my work has primarily focused on the genetics of obesity and how these genes may also increase an individuals risk for the development of other diseases such as diabetes and coronary heart disease. To date my work in obesity has utilized data from Mexican American family members participating in the San Antonio Family Heart Study . A major quantitative trait locus determining serum leptin levels and fat mass is located on human chromosome 2. Shared and Unique Genetic Effects Among Seven HDL Phenotypes.
Triiodothyronine exerts a major pleiotropic effect on reverse cholesterol transport phenotypes.
Genetic and environmental correlations among hormone levels and measures of body fat accumulation and topography. A major gene with sex-specific effects influences fat mass in Mexican Americans. Last modified 1 Feb 2000.