Special attention is focused on the calcium release protein of the sarcoplasmic reticulum.
The effects of sulfhydryl oxidizing and reducing agents has been used to unravel the mechanism by which this protein gates and controls the contractile state of muscle. The mechanism of oxidative damage induced by ischemia and old age is also presently being examined as are the effects of cardioprotective agents used in cancer therapy. Feng,W., Liu, G., Abramson, J. Xia, R., and Pessah, I.N. Site-selective Modification of Hyperreactive Thiols on Ryanodine Receptor Complex by Quinones. J. Applied Physiol. J.J. Reactive oxygen species activate calcium release from skeletal muscle sarcoplasmic reticulum.