Ischemic strokes represent approximately 85 percent of all strokes. TPA has been proposed as a treatment for an ischemic stroke of any source. TPA can be an effective means for dissolving the blood clot and restoring blood flow to the brain in patients with ischemic stroke if it is given as part of a rigorous protocol under the appropriate conditions, says Dr. Chiu. TPA is not an option for hemorrhagic strokes. A major concern with TPA is its very specific window of time.
Timing is critical.
There is a higher risk of bleeding in the brain beyond three hours. The benefits of TPA can be dramatic. However, the risks are very real. If the proper protocol is not followed, the risks may outweigh the benefits. Other emergency intervention therapies are currently in the research phases, including a category of drugs called neuroprotective agents.