The toenail disorder seen in the IWS is not at all well understood. It seems to appear in young adults who may begin to manifest symptoms by chewing on the feet. The problem can occur in dogs whose feet are regularly trimmed. The disease will progress even if infection is not present. One or many toes may be affected.
Some owners report satisfactory treatment by eliminating dietary allergens.
Others have opted to have the dog's toes removed. Treatment is necessary to avoid suffering. A genetic component is suspected due to occurrence in related individuals, but very little is known of this condition. Since several of the disorders mentioned above are physiologically interrelated, an explanation is included here. The immune system protects the body from foreign substances, including infectious agents like bacteria and viruses.