601 Elmwood Ave., Box 712, Rochester, NY 14642. Applicants should send three letters of recommendation and be prepared to speak on their thesis work. BACK TO TOP Postdoctoral Positions with Dr. Maquat Postdoctoral positions are available to study the mechanism by which nonsense codons elicit mRNA decay in mammalian cells . Nonsense codons, caused by either frameshift or nonsense mutations, are responsible for an estimated one-third of inherited genetic diseases. If the resulting premature termination of translation can be abrogated even slightly so as to increase the amount of full-length protein synthesized, then the abnormal phenotypes of many diseases can be abrogated.
Significant projects are available in molecular biology, biochemistry and cell biology.
Successful candidates will join a well-equipped group of interactive lab members with diverse backgrounds and expertise in newly remodeled labs. The University of Rochester is unique for its sizeable community of RNA researchers and its interest in clinical approaches to modify disease-associated gene expression by modifying RNA metabolism. It is effective against a wide range of diverse drugs. In AIDS, P-glycoprotein is important because it causes poor absorption and low efficacy of protease inhibitor drugs. A new yeast expression system recently perfected by our laboratory is facilitating progress.