No clinical manifestations None needed Factor XIII Autosomal recessive Bleeding from umbilical stump, poor would healing. Platelets in Liver Disease Decreased platelet number due to sequestration by spleen. Decreased platelet number with underproduction due to folic acid deficiency, acute alcohol ingestion, sepsis. Abnormal platelet function due to FDP, etc. Thrombin clottable protein Significant reserve depressed only when liver failure severe.
Thrombin catalyzes fibrin formation and results in consumption of fibrinogen.
Thrombin activates coagulation proteins V and VIII and, by cleaving protein C, promotes their inactivation. Thrombin aggregates platelets, resulting in thrombocytopenia. These effects result in diffuse hemorrhage and microthrombus formation. DIC is a common syndrome due to diverse etiologies which initiate thrombin formation by various mechanisms. Self-evident Fluids, blood, respiratory care, pressors, etc.