Some follow a modified vaccine schedule or use only killed single vaccines in minimal doses. Others use homeopathic nosodes. Many give only a modified puppy series and skip the annual boosters. Your decision will be based on your level of comfort as well as your animal's overall condition. Homeopathic nosodes are substances prepared from the infected tissue, disease discharge, or casual organisms of the particular disease of concern.
Some people seek assurances of immunity by checking antibody titers for the disease of concern.
Nosodes do not build antibody titers, so checking titers for nosode effectiveness is not productive. If you decide to check your animal's titers, be sure the lab does post-vaccinal titres so that the numbers accurately reflect your animal's titers.