These creams are usually applied twice daily. They should be started before the symptoms begin and continued through day 2 or 3 of the menstrual period. For more severe PMS, prescription strengths of natural progesterone will be required. When discussing this with your doctor, make sure to clearly express your desire for natural progesterone. Synthetic progesterone-like substances, known as progestogens will make PMS worse by inhibiting the production of natural progesterone by the body, thereby worsening the hormonal imbalance.
Side effects appear negligible.
It doesn't affect cholesterol levels, it doesn't affect Mother Nature-basically, it is a wonderful thing.