They may also prolong and complicate labor and delivery. Studies in animals have shown that ASA and caffeine causes birth defects. ASA and opioid analgesics cross the placenta. Salicylates should be administered with caution to patients with asthma and other allergic conditions, with bleeding tendencies, or with hypoprothrombinemia or in patients prone to dyspepsia or known to have a lesion of the gastric mucosa. Caution is necessary when renal or hepatic function is impaired.
Salicylates can produce changes in the thyroid function tests.
ASA may precipitate or worsen attacks of gout. Opioid analgesics may cause dryness of the mouth. For temporary relief, use sugarless candy or gum, melt bits of ice in your mouth, or use a saliva substitute. If dry mouth continues for more than 2 weeks, check with your dentist. Do not take this medicine for 5 to 7 days before any surgery, including dental surgery, unless otherwise directed by your physician or dentist.