IMP Our studies focus on the mechanisms that regulate the immune response. We are pursuing three areas of investigation. First, the factors that maintain tolerance of T cells to secreted and nonsecreted self proteins are being identified using transgenic mouse models. Third, we are testing whether the information learned in the above studies can be used to treat autoimmune diseases and transplantation.
T lymphocytes regulate the induction and maintenance of oral tolerance.
R.L. Hunter and J.A. Kapp. 1997. Nonionic triblock copolymers facilitate delivery of exogenous proteins into the MHC class I and II pathways. J.R. Maleckar, T.L. Kirley, J.W. Thomas and J.A. Kapp. 1997. All Rights Reserved.