Intranuclear inclusion bodies found with herpes, adenovirus and parvovirus. Many inclusion bodies are accumulations of viral structural components. May be masses of viral nucleocapsids. Effects of Virus on plasma membrane. Polarity of Budding.
Viruses insert viral glycoproteins into the plasma membrane in the course of their replication.
Viral glycoproteins are not inserted at random. Viruses exploit cellular pathways for the synthesis of glycoproteins and their insertion into the membrane. The programmed addition of sugars occurs sequentially as the protein moves in vesicles from the RER to the Gogli complex, and then to the plasma membrane. The side chains of viral envelope glycoprotiens are generally mixtures o simpel and complex oligosaccharides, which are usually N-linked to asparagine, and less commonly to serine or threonine. The type of glycoprotein is determined by the glycsyltransferases prevelent inf the type of cell in which the virus is growing.