Many people with HMSN experience fatigue. This may further affect an individual's balance or ability to bend over. Hammer toes or clawed toes may develop. Weakness, accompanied by tremors may be experienced in the hands and forearms, usually in later stages. The intrinsic muscles of the hand can atrophy and the fingers can claw.
Wrist drop can occur.
As a result, fine manipulatory acts may become difficult. For some, numbness may be a problem in both hands and feet, resulting in an increased risk for affected individuals to injure themselves without realizing it. Painful sensations on the soles of the feet and palms may be a problem and sciatic nerve pain is not uncommon. Some individuals may experience breathing difficulties, re-sulting from weakness in the muscles of the diaphragm. Shortness of breath, dizziness, morning headaches, fatigue and pain in the rib area may result.