Pathological conditions associated with FHC, ischemia and stunning are linked to structural remodeling of cardiac myofilaments. Such remodeling, caused by mutations, proteolytic clipping or changes in isoform expression, can have a major impact on myofilament function through changes in protein-protein interactions. Selected Publications Biographical Information Chandra, M. , W.-J. Dong, B.S. Pan, H.C. Cheung, and R.J. Solaro. D.E. Montgomery, J.J. Kim, and R.J. Solaro.
T is essential for maximal activation of cardiac myofilaments.
Chandra, M. , J.J. Kim, and R.J. Solaro. An improved method for troponin exchange in detergent skinned rat cardiac fiber bundles. Pearlstone, J.R., M. Chandra , M.M. Sorenson, and L.B. Smillie. V. McManus-Rundell, J. Tardiff, L.A. Leinwand, P. de Tombe, and R.J. Solaro. J. Physiol .