Squirrel houses should be placed away from human dwellings at least 15'above the ground. They should face south and away from prevailing winds. Boxes can be cleaned in mid to late summer if there are no babies present. Many people decide that they just can't live with the squirrels. The squirrels may be doing too much damage to electrical wiring, in the garden, or to human structures.
Squirrels can be live trapped.
Be sure to check with your state agencies for any regulations that may apply to trapping animals. One problem with relocating is that if the squirrel is relocated to an already populated area, the newcomer may create a disruption. The disruption could cause the relocated squirrel to be driven out of the area by more aggressive squirrels or be the cause of existing squirrels being driven out. This can result in either one being homeless and without adequate food source. Some squirrels have been known to be traumatized to the point of death during transportation.