Thalassemia minor has less prominent symptoms.
Have erythroblastemia and marked changes in the size and shape of the red blood cell. The treatment is splenectomy. A generalized osteopenia is seen with decreased trabecular prominence, a widened medullary space, and thin cortices. These findings are most marked in the hands and femurs. Twenty-three percent of patients greater than 10 years old have premature epiphyseal fusion.