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We are faced with the facts that educational resources have become progressively scarcer, clinical teachers have less time for teaching, and patients with classical presentations are not available when the curriculum calls for them. When I was a medical student, I received my information from lecture and books, then I converted the information to knowledge at the bedside and in the laboratory. It is this latter activity which is threatened most by the resource shortage. While I do not propose that CAI can replace the actual clinical experience, I propose that appropriately designed programs can supplement reduced clinical exposure. A concise theoretical framework of the different diseases and their investigation is provided.