Nuclei are so hyperchromatic and irregular that nucleoli are rarely visualized. Although there are fusiform, oat, and intermediate cell types, no difference in outcome. Dense core neurosecretory granules. May stain with chromagranin, neuron specific enolase, or synaptophysin. Highly aggressive neoplasms that frequently present with evidence of metastatic disease.
Treatment depends on chemotherapy.
Robbins Pathologic Basis of Disease. Search Medline at National Library of Medicine Please be patient during transfer. Medline will open in a new window.