The Home resides on a beautiful, wooded site inside the city limits, just off Highway 425. At the first traffic light South of the US 425 and US 278 intersection in Monticello, turn right onto Old Warren Road. Vera Lloyd Home nestles in the tall pines and hardwoods on the left. Turn left at the second campus entrance, just past stately Williamson House, and follow the road to the gymnasium.
Staff offices are in the front of the building.
University Avenue can be reached from Interstate 630 or from Cantrell Road.