The new synapses might then be incorporated into new networks to support new memories. Future goals are to develop animal models and add molecular biological tools to these structural and physiological approaches to investigate the synaptic basis of normal learning and memory as well as mental retardation. Developmental onset of long-term potentiation in area CA1 of the rat hippocampus. Cellular specializations that impart stability and flexibility to synaptic function. Synaptogenesis via dendritic filopodia in developing hippocampal area CA1.
Slices have more synapses than perfusion-fixed hippocampus from both young and mature rats.
Three-Dimensional Relationships between Hippocampal Synapses and Astrocytes. Dendrites are more spiny on mature hippocampal neurons when synapses are inactivated. Structure, Development, and Plasticity of Dendritic Spines.