In addition, elevated concentrations of CGRP were found in cerebrospinal fluid. Significant increases of HWLs were measured in rats treated by intrathecal administration of the CGRP antagonist, CGRP 8-37 . These effects were reversed by intrathecal administration of naloxone and by treatment with selective opioid antagonists directed towards g and 8 receptors. In other studies, intrathecally applied NK1 and NK2 receptor antagonists were followed by increased HWLs. The use of a non-peptidergic tachykinin receptor antagonist showed similar effects.
Thermal injury induces severe inflammatory reactions.
Our studies demonstrate a contributory role of the nervous system and the release of sensory neuropeptides. By modulation of activity in the nervous system both edema formation and nociceptive transmission can be reduced. The knowledge may lead to the development of new treatment strategies.