Normal rhizome depth is apparently inversely related to the thickness of organic soil. Also sprouts from the stem base when disturbances such as fire destroy only portions of the aboveground foliage. Self-sterile, requiring insect pollination for fruit set. In commercial blueberry fields containing both velvetleaf and late low blueberry, yields are often lower than in fields made up of only late low blueberry. Cross pollination apparently results in reduced fruit set.
Seeds can germinate on mineral or organic soils when moisture and aeration are adequate.
Seed dispersal by various birds and mammals. The American robin is a particularly effective dispersal agent. Fruit typically ripens just as birds are preparing for seasonal migrations. Seedling establishment typically slow wherever significant competition is present. Berry production fluctuates annually according to the genetics of the individual clone, weather conditions, and insect availability.