They are scaffolds for other cells to function on. Using human fibroblasts as an experimental model system, we are identifying genes that are upregulated by oxidants using genomic and proteomic approaches. These approaches in combination with classical molecular techniques allow us to searching for the critical molecules that control a series cellular changes resulting from oxidant exposure such as premature senescence and apoptosis. The Relationship between Cellular Senescence and Carcinogenesis. The risk of cancer increases exponentially with age for humans after 40 years old.
Statistics also shows an increased mortality rate of cancer with age.
To understand the contribution of aging to cancer, we have developed a co-culture system to study the role of cellular senescence in tumor promotion based on the concept of the multistage carcinogenesis. We have found that senescent cells or senescent-like cells benefit the growth of initiated cells, indicating that these cells may function like an endogenous tumor promoter. We are exploring the mechanism and implication of this phenomenon. The Role of Oxidative Stress in Heart Failure. Cardiovascular disease is the number one killer worldwide.