Self Test Set 2. Fall 2000 Self Tests, Set 2. Of course you need to write out your answers to these questions, to make effective use of the questions. Answer questions 32-39 from last year's midterm. Lymphocytes undergo a phase of antigen-independent development in the thymus or bone marrow.
Sharks have only a single type of heavy chain constant region, whereas humans have eight.
We understand that the single heavy chain locus present in the human genome contains a single constant region gene segment for each of the types. Antibody diversity is explained in part by combinatorial diversity, in part by junctional diversity, and in part by inherited diversity. Explain each of the three types, and make sure that your answer makes clear the difference between the three. An explicit evo-devo connection we made in the course was between this character in a body fish, and the only skull present in a shark. Explain the significance of skull fenestration for understanding tetrapod relationships.