Non-covalent binding results from a toxicant physically binding to a molecule. The relative quantitative significance of toxicity is identical to the biological significance. Sec 2 Toxicity may be classed as reversible or irreversible. Open organelles in a cell are good for the cell. Type B reactions are pharmacologically predictable.
Scientists can test as to whether a drug causes lipid peroxidation in the lab.
Lipid peroxidation produces malondialdehyde and singlet oxygen but not conjugated dienes. Type B toxicities often occur due to the action of a metabolite. All toxicities are considered emergencies. 3 Free radicals must travel to result in local damage. Covalent binding is generally a problem of reactive metabolites.