In addition to finding novel functions for previously described proteases, we have isolated novel enzymes and factors which affect the rate of breakdown of cellular proteins. We are also studying several compounds which accelerate or retard the rate of protein synthesis and degradation in mammalian cells and tissues.
Sepsis increases oxidatively damaged proteins in skeletal muscle.
Archives of Surgery. Activation of the multicatalytic endopeptidase by oxidants. Effects on enzyme structure. ATP-stimulated degradation of oxidatively modified superoxide dismutase b cathepsin D in cardiac tissue extracts.