There were no clinically significant lab abnormalities detected. The data from the 4S trial was used as the basis for determining cost effectiveness. Simvastatin was cost effective in both men and women, young and old. Obese subjects lost significant body fat, increased exercise capacity, improved lipid profiles, improved scores for anxiety, depression, somatization and quality of life. Non-obese patients experienced an even greater increase in exercise capacity.
Weight reduction is associated with greater benefit of cardiac rehab.
Ten healthy normocholesterolemic subjects were studied. Two were receiving treatment with an HMG Co-A reductase inhibitor for borderline hypercholesterolemia. Blood pressure, heart rate and endothelial function was measured hourly for 6 hours. Fasting LDL was inversely correlated to preprandial flow-mediated vasoactivity. The recent decline in mortality from coronary heart disease, 1980-1990.