It is critically important to see a doctor and get diagnosed early. It is also important for doctors to aggressively treat infections with prolonged high doses of antibiotics. To prolong infection-free periods, physicians often prescribe continuous preventive oral antibiotics, such as trimethoprim combined with sulfamethoxazole. Abscesses often require surgical drainage. The granulomas ultimately resolve with long-term antibiotic therapy.
Steroids reduce the gastrointestinal and genitourinary tract obstructions.
Patients with anemia may require whole blood transfusions. Patients have been treated successfully with bone marrow transplantation, and this may be an option if a suitable donor can be found. Gene therapy is under investigation. They also developed the approved CGD treatment that uses gamma interferon. This treatment reduces the number of serious infections by up to 72 percent.