There is also accumulating evidence that free radical generation plays an important role in ototoxicity. This information is the basis of experimental treatments to prevent ototoxicity. The rotatory chair test is essential to document the characteristic reduced responses of both ears to motion. Other diagnostic studies may be helpful. A chest X-ray and ACE test may be done if sarcoid is thought likely, and a Lyme titer may be obtained if there has been exposure.
Treatment involves determining the cause and treating it, if possible.
This is a condition that realistically causes some permanent disability. In patients with gentamicin induced ototoxicity, the symptoms generally peak at three months from the last dose of gentamicin. Most individuals are able to continue to work productively in spite of complete or near-complete loss of vestibular function. While crutches, canes, walkers and wheelchairs may be necessary in the first three months, appliances are rarely needed after a year has passed. After 20 years, most patients have returned to near normal for their age.