Papules often coalesce into circinate or arcuate plaques. The face and extremities are primarily affected, characteristically in an asymmetric distribution. Ulcers and bullae are more common in malignancy-associated disease, may be extensive and are generally harder to treat. Mucosal lesions Oral lesions can occur but are not common. Conjunctivitis and episcleritis may also occur and are the most common eye manifestations.
Sweet syndrome has the potential to involve several other organ systems.
Pulmonary manifestations are the most common extracutaneous findings and may manifest as a chronic cough or pulmonary infiltrates on chest x-ray. Proteinuria, hematuria and decreased creatinine clearance have been reported. Cerebral spinal fluid pleocytosis has also been described, as has a sterile chronic recurrent multifocal osteomyelitis in children. Lesions occur in areas of trauma such as bites, scratches and venipuncture. Hematologic malignancy Myelodysplasia and chronic myelogenous leukemia may be associated with Sweet's syndrome.