When it goes down - you lose water. Central nervous system depressant not exactly how it works. So it must depress inhibitory centers of the brain. Make sure you understand this. Long term effects atrophy of the brain.
Tolerance develops - through increases in liver enzymes .
During pregnancy leads to FAS - fetal alcohol syndrome. 1-2 drinks a day doesn't have an effect. Mental retardation - FAS is 3rd highest known cause of mental retardation. May be on it. 3x as potent as morphine.