Negative imaging studies and the lack of symptoms in other parts of the body, tended to exclude the possibility of metastatic disease. A bone biopsy was done which had the following appearance. An amputation of the lower extremity was done. The following photo shows the lesion. Note that the tumor has a variable appearance.
Some areas seem to be making more bone-like material than others.
There were firm, pale lesions in many of these vertebrae. Assuming that they represented malignancy, suggest a plausible cell of origin.