Go to Main Page. If TSH is abnormal, L-thyroxine should be used in sufficient doses to bring TSH into the normal range around 1 microgram per pound of body weight. Referral to endocrinology may be required depending on clinical status.
Several studies support the second strategy.
However, there are no data on direct comparison of lithium versus valproate or carbamazepine for rapid cycling. Finally, most studies of rapid cycling derive from tertiary care clinical centers that tend to select for nonresponse to conventional or conservative treatment. This is a conservative stance, taken in recognition that definitive studies of anticonvulsants in this disorder are yet to be done. Kukopulos et al. I IIa A C Valproate Calabrese et al.