Research relating to the utility of these models for the design and analysis of laboratory and epidemiology studies and for risk estimation is planned. Applicants should have a strong background in computer modeling and some experience in modeling biological systems. The molecular mechanisms of cellular senescence are being investigated. Candidates should have experience in studying the mechanisms of cellular senescence as documented by outstanding publications in this area. The inositol polyphosphate phosphatase compartmentalized in the lumen of endoplasmic reticulum has been cloned.
Some studies use luciferase constructs to study upstream regulatory elements.