I would try to avoid taking the 300mg dose very often, as it will affect your daytime performance because of the hangover effect your doc mentioned. I hope that this is of some help. Trazodone is not used much as an antidepressant anymore because it is far too sedating. The serotonin syndrome is definitely dose related. When we lowered the trazodone to 25mg, the symptoms of serotonin syndrome went away.
Trazodone is one of the safest sleeping pills for seniors, as well.
I would try to avoid taking the 300mg dose very often, as it will affect your daytime performance because of the hangover effect your doc mentioned. I hope that this is of some help.