The author obtained good results in vitro and in vivo with tumor lines overexpressing tyrosine kinases of some growth factors and their receptors. These enzymes might be considered as interesting new targets for antitumor agents for some tumors overexpressing these enzymes. He studied NAD analogues as a new class of inhibitors for NAD- dependent enzymes. Thymidylate synthase is a long-standing target for chemotherapeutic agents due to its central role in DNA synthesis. It is still an excellent target for antitumor and antiviral agents.
Thymidine is a biomodulator of alkylating agents.
It protects the cellular immune response and organ function from alkylating agents through modulating DNA repair enzymes. Thus it protects from toxicities and potentiates treatment efficacy. Many research centers are active in search for tumor-specific antigenes as a promising route, not only to immunotherapy, but also for tumor chemotherapy. They also developed a new theory concerning the molecular mechanisms of the mediation by anthraquinone antitumor agents of one electron transfer, inducing peroxidation effects and cardiotoxicity. Also very important results on molecular aspects of rational design of anthraquinone antitumor agents overcoming MDR were shown.