Individuals successful at long-term maintenance. With this combination of diet and medication, weight loss peaks in 6 months. Less weight is regained with the combination of diet and orlistat than with a control group on diet and placebo in a 2-year trial. For sibutramine, only 1-year treatment data are available. The effect is dose dependent, and patients with type 2 diabetes lose less weight.
Weight is regained when either drug is discontinued.
Orlistat, which acts locally, may be associated with localized adverse effects, whereas sibutramine acts centrally, inhibiting serotonin and noradrenaline reuptake, and can use cause systemic effects. Better than slim chances for orlistat and sibutramine to promote weight loss.