The histological diagnosis was grade 3 transition- al cell carcinoma. Immunohistochemical analysis showed CA19-9 to be expressed not only in the cancer cells but also in the normal transitional cell epithelium of the renal pelvis. We report a case of transitional cell carcinoma of the fossa navicularis in an elderly white male. The patient presented in urinary retention, with a large exophytic mass at the external urethral meatus. Both the pathogenesis and natural history of this highly unusual tumor are unclear.
Treatment depends on grade and stage of disease.
Transurethral resection and fulguration have been successfully used to treat superficial lesions. The role of chemotherapy for advanced disease is unknown. The histopathological diagnosis was squamous cell carcinoma of the ureter, G1 INF beta, pT2, pR0, pV1 and pL0. Three cycles of chemotherapy were performed postoperatively with cis platin and 5-fluorouracil. No evidence of the tumor relapse was found 7 months after irradiation.