Robert Nibbs Figure 1 Lymphatic vessels staining with a monoclonal antibody specific for D6. The D6 antibody is detected as the red staining. Nuclei are stained with haematoxylin.
Stars indicate the lumen of the vessels.
Our current research focuses on the biological and pathological consequences of interactions between chemokines and their receptors, and additionally aims to develop therapeutic strategies targeting these molecules. Chemokines are central to leukocyte chemoattraction and consequently affect immune responses during infection, allergy, autoimmunity and tumour development. Moreover, chemokine receptors can act as co-receptors for entry of HIV into its target cells, as well as having a role in development and neuronal function, and, of particular interest to us, in endothelial cell biology. We have applied a broad array of molecular and cellular biological techniques to two central areas of research. Modified forms of these proteins have been synthesised with enhanced activity that may have potential therapeutic application.