Take salsalate with milk, food, or an antacid to lessen stomach upset. Do not take salsalate more often than every 4 hours, and do not take more than is recommended. If your condition does not improve within 3 to 4 days, seek medical attention. Do not take any salsalate that smells strongly of vinegar. This smell means that the drug has begun to break down.
Store salsalate at room temperature away from moisture and heat.
If more than 2 hours have passed since the missed dose, skip the missed dose and take only your next regularly scheduled dose. Do not take a double dose. If you are taking salsalate on an as-needed basis and you miss a dose, take it as soon as you remember and do not take another dose for at least 4 hours. Seek emergency medical attention. Symptoms of an salsalate overdose include ringing in the ears, headache, nausea, vomiting, dizziness, confusion, hallucinations, coma, seizures, rapid breathing, and fever.