In most patients, however, only a single lesion is felt. Because we are not certain of the reason for Peyronie's disease, it is difficult to plan any treatment that is universally effective. There is no definite cure for Peyronie's disease. Spontaneous regression and disappearance of Peyronie's disease and all of the symptoms does occur in some patients, and therefore, therapy which is not particularly risky or aggressive is justified. Occasionally these drugs will soften the plaque and relieve the symptoms.
Vitamin E is safer and cheaper and has no side effects.
It is far and away the most common initial treatment plan. We usually use 400-500 units two times a day. Failure to resolve the symptoms in 12 months usually means that this treatment will not be effective. Treatments that have been recommended or tried in the past include steroid injections into the plaque, ultrasound, and radiation therapy. None of these treatments have been uniformly effective.