The mechanism of MAOI can be used to potentiate most classes of tryptamines as well as many other classes of drugs. There is current worldwide interest in Ayahuasca for entheogenic exploration. We aim to reduce harm and promote safety by expounding on potential contraindications of MAOIs with foods and pharmaceuticals. Entheogenic tryptamines are orally activated by MAOI's inhibition of the enzyme monoamine oxidase in the gut.
Sufficient exposure can therefore cause a norepinephrine surge resulting in hypertension.
Symptoms include nausea, occipital headache, and even intracranial hemorrhage. Increased norepinephrine release is also compounded by stimulants, including amphetamines and other amines. Of course, those with psychiatric preconditions, especially prior psychotic breaks, should avoid entheogens, except when mediated by a professional. Those considering self-induced exploration should be aware of its complications and make an informed decision. The restrictions here delineated are not meant to be all-encompassing but, rather, are meant to provide general guidelines.