The role of glutamate transmission in the substantia nigra pars reticulata in the control of posture and movement. In the behaving rat, inhibition of the SNpr with GABA agonists or Glutamate antagonists has been shown to produce postural asymmetry and contra-laterally directed locomotions. The aim of this study was to determine to what extent inhibition of the glutamate transmission in the SNpr might reproduce the effects of GABA agonist in the monkey. Therefore, we conclude that glutamate transmission in the SNpr is not involved in the suppression of contra-lateral limb dyskinesia. More protection against seizures without neurotoxicity afforded by higher ketogenic ratios.
Starvation is a means to control seizures.
The ketogenic diet, although its mechanism is unknown, has been proven useful in the elevation of seizure threshold. Also, unlike other antiepileptic drugs, the ketogenic diet does not appear to cause adverse side effects. There is a direct relationship between the ketogenic ratio and seizure threshold. A TD 50 value for the ketogenic diet could not be determined.