Shelly, based on the observations of follicular occlusion, proposed topical tretinoin cream therapy in 1972. Reports of success with topical retinoids followed, along with reports of success with topical steroids, antibiotics, clindamycin in alcoholic propylene glycol solution, hormonal therapy in women, ultraviolet light, dermabrasion, and surgical excision. Usually these therapies were not curative and often complicated by intolerable irritation. Consultation with a dermatologist usually is recommended. Activity that leads to sweating is counterproductive.
Swimming is the preferred form of exercise.
Topical steroids have not been useful. Topical retinoids have been irritating, which has limited their long-term use. Miller reported treatment of Fox-Fordyce disease with topical clindamycin solution in 1995. Hormonal therapy with high-estrogen oral contraceptives, estrogen creams, and testosterone cream has been reported, sometimes with success and often with failure. Consider therapy with alternative retinoids as they become available.