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Some recommendations suggest to take it before eating.
Others suggest to take it with meals. The Natrol web page for their Tonalin CLA product says to take it preferably with lowfat or nonfat milk for maximum protein absorption. Some people report feeling slightly green or nauseous after taking their CLA, or isolated cases of gastrointestinal upset or loose stools. I also noticed that my appetite was somewhat reduced. I had two or three days my first week when I felt a bit green after taking my CLA, but I began to take it with a bit of milk, which eliminated that problem.