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Sleep disturbances are common in people with either mania or depression.
Specifically, the difference between daytime and nighttime levels was much smaller in SAD patients. Together, these observations would suggest a role for melatonin in various forms of depression. Artificial light can also impact blood melatonin levels. Appropriately timed light therapy is reported to be efficacious in the treatment of seasonal affective disorder. Blood melatonin appears to respond to other environmental cues such as seasonal and temperature changes.