In Humans acute OP poisoning can lead to cholinergic crisis. OP poisoning also leads to Intermediate Syndrome and Peripheral Neuropathy. Thus incidence and severity of pesticide exposure and poisoning is assessed with methods of diagnosis. Measurement of acetylcholinesterase enzyme activity forms a funtional index of toxicity in OP exposure. Information transfer in the neurons in the brain is accomplished by release of the chemical-neurotransmitters, at the nerve endings.
Toxic stress has a significant impact on neurotransmitters.
Alteration in neurotransmitter level also reflects on the toxic effect of the test compound. Neurotransmitter changes, acetylcholinesterase enzyme activity and biochemical studies were thus conducted to study the toxic effect of the test compounds aluminium chloride and acephate.