Proteus Syndrome is a variable and complex disorder characterized by multifocal overgrowths affecting any tissue or structure of the body. As of 1999, roughly 120 cases had been reported in the literature. The aetiology of this syndrome is unknown. Currently it is thought to be secondary to mosaicism of a post-zygotic early mutation.
Treatment involves orthopaedic and plastic surgery intervention.
Our patient demonstrated asymmetrical features, macrodactyly and overgrowth of the hands and feet, numerous vascular and soft tissue malformations, and scoliosis. Therefore, we conclude that our patient most likely has a forme fruste of the syndrome. Scoring System for diagnosis of Proteus Syndrome. Proteus syndrome and hamartoses with overgrowth. My thanks to Drs.