The bone that forms is poor in quality and allows for fractures. Note the expansion of the jaws in the models to the right compared to the normal patient on the left. Note the ground glass pattern on the radiographs and the loss of the lamina dura. Also, note the hypercementosis on the premolar tooth. The top histology specimen shows hypercementosis with Paget's bone to the left having replaced the normal bone and periodontal ligament.
Treatment is empirical with calcitonin giving help to some patients.
These patients may also have giant cell lesions of the bone. Some patients develop sarcomas of the bone.