Although PGE 1 had been administered for 28 days, it had no effect at least 3 days after the start of administration. Blastic crisis occurred 1 year after developing ulcers, but the relation between the ulcers and blastic crisis is unclear. The results of this study indicate that HU administration should be interrupted to allow for healing of ulcers. References 1 . Sarcoma 180 screening data.
Skin changes secondary to hydroxyurea therapy.
Abstract 3 . Stahl LR, Silber R. Vasculitic leg ulcers in chronic myelogenous leukemia. Masuoka H, Kobayashi M, Kaito K, Yoshida M, Sekita T, Saeki A, et al. Bilateral ankle ulcers associated with hydroxyurea therapy for chronic myelogenous leukemia. Abstract 5 .