Each of the known ovarian and adrenal steroid sex hormones plays numerous roles in maintaining the harmonious workings of the entire self. Studies of post-40 year old women on HRT have been reviewed to assess the benefits and risks of various regimens. Given diverse regimens of both natural and synthetic hormones, physicians should consider results of each study as specific to the type and pattern of hormone use and only generalize with caution. The harmonic nature of the fertile reproductive system forms the background against which HRT can be understood to best serve women. Not all hormonal replacement therapies and wellness regimens serve women well.
Some regimens profoundly improve the quality of life for many women.
Some women do not need or want such regimens. All sex hormones affect physiologic systems including the cardiovascular system, bone metabolism, cognitive function, sexual response, and sexual attractiveness. The complex contributions to the overall health of a woman may not always be understood. One in 2 American women is offered a hysterectomy, a rate 5 times higher than that of the European countries for which data are available. No efficacy data exist that suggest that elective hysterectomy works better than the alternative approaches that do not induce these side effects.