These skin lesions coalesce and then slowly ulcerate leading to necrosis. This is often accompanied with cerebral infarction. Overall, this condition is usually fatal. This is a condition also associated with congenital Protein C Deficiency. Skin and fat necrosis occurs when warfarin is given.
Treatment is by stopping warfarin and instituting heparin.
B. Acquired Protein C Deficiency 1. Clinical features are similar to congenital Protein C deficiency and Antithrombin III deficiency. Protein C Deficiency A. Acute thrombosis should be treated with heparin. B. Long term prophylaxis can be undertaken with warfarin. When starting warfarin, very low doses must be used initially to prevent skin and fat necrosis.