Before you make your choice, be sure to factor in any human considerations. On the other hand, keep in mind that software in general, and database software in particular, is getting easier to use. Don't let lack of experience keep you from trying a database. It's easier than you think. Summary In summary, databases allow for better error checking, for better integration of data from multiple sources, and for better handling of very large files.
Spreadsheets are faster to get up and running, which can be an advantage for small tasks.
Spreadsheets also have an advantage when there are repetitive patterns in the data. It may come down to how large and complex your data set is. The bigger and messier the data, the more a database can help .