Signs include rippling skin on the cat's back just above the tail, widely dilated pupils, staring into space, persistent loud meowing, and sudden bouts of dashing off madly and aimlessly around the house or yard. Frequently a specific event is triggered while a cat is experiencing what she loves the most being petted by her owner. Although occurring with no observable pattern or predictability, an episode may be initiated when the cat's lumbosacral area near the tail is stroked. For some reason this sets off motor activity, possibly similar to a pain response. Since feline hyperesthesia syndrome is not a specific disease, but rather a set of signs, treatment cannot cure an afflicted cat, but merely mitigate the severity of these signs.
Some cats respond well to corticosteroids.
Others respond to anticonvulsant medications. In any case, a cat suffering repeated episodes should be taken to a veterinarian for a complete physical examination, including a neurological work-up, as the first step in making the correct diagnosis and relieving the cat from this mysterious affliction. We have links about cat health on our Cat Health-Related Links page. I'll give you a link to it here.