Run a few plays on both sides of the ball and familiarize yourself with the controller you're playing with, the button commands, and the overall speed and dynamics of the game. There are many more button commands that are useful such as, Coach's Cam, Flip Plays, Pump Fake, etc. Set your offensive and defensive audibles with high percentage plays you are comfortable with. On offense, mix it up with both running and passing plays, long and short. On defense, pick some blitz packages and some sets that feature multiple defensive backs.
Variety is the key.
For example, if your team features a solid running back, feed him the ball about 30 times a game. If you're playing against a team with a scrambling quarterback, put your linebackers in position to contain him in the pocket. If you have a kicker with a strong leg, then you know you can attempt a field goal from 50 yards away rather than punting. It's the little things that could turn your season into a winning one. In order to make it to the title game, you must dominate the field on both sides of the ball.