Antimetabolites act as false building blocks in a cancer cell's genes, causing it to die as it gets ready to divide. Fluorouracil, or 5-FU, is an antimetabolite. Antimiotic agents or natural agents inhibit the ability of cellular genes to replicate during division. Antimicrotubule or natural agents interfere with cell structure and cell division.
Tamoxifen is the most widely used anti-estrogen or hormonal medication in adjuvant therapy.