You can't even use threads in Perl without breaking half your code and worrying about the next release changing how it works. As you may have noticed, I've gotten into Zope . It's a killer app. Python hasn't really had any killer apps that businesses can really take advantage of. Zope is unique in that it is very useful and really shows the coolness of Python.
Web programming tends to be redundant.
Zope removes much of this drudgery of web programming, and does it in a nice OO way. It's really slick. The web or http protocol is not some sort of great plan to make networked applications accessible to everyone. If it were, it would be far easier to actually write applications for. The fact is, it's a document exchange protocol.