There are usually regular stops along each route at the major intersections. If you are on the bus and want the driver to stop, push the tape that is along the bus walls at regular intervals. You have to enter the bus from the front and it's best to exit from the rear, unless you happen to be near the front or if the bus is empty. If you or someone with you uses a wheelchair, you can only enter through the rear. All buses are wheelchair-accessible and the driver will lower and raise the special apparatus for you.
Some buses run express from the boroughs into Manhattan during rush hour.