The cell of origin of granular cell tumors is still controversial, but schwannian origin is favored by most investigators. 8 Granular cell tumors mostly follow a benign course. Nevertheless, some authors recommend complete excision with uninvolved surgical margins to prevent clinical recurrence. A significant number of neoplasms of diverse lineage that occasionally show granular features must also be excluded, including xanthoma, granular cell epulis of infancy, granular basal cell carcinoma, granular cell dermatofibroma, rhabdomyoma, and rhabdomyosarcoma. Virchows Arch A Pathol Anat Histopathol.
Soft tissue tumours.
Textbook of Dermatology. Lack EE, Worsham GF, Callihan MD, et al. J Surg Oncol. Granular cell myoblastoma. Horowitz IR, Copas P, Majmudar B. Granular cell tumors of the vulva.