Go easy on tea and coffee, which can contribute to dehydration and sleeplessness, and can aggravate digestive problems. If you use alcoholic beverages, do so sparingly, if at all. Alcohol increases the risk of dehydration and stomach upset. There is an American-operated hospital in Istanbul. Luxury hotels often provide North American-style 110 volts as well.
Turkey is on Eastern European time, seven hours ahead of New York.
When it's noon in Turkey, it's 5 am in New York and 2 am in Los Angeles. Turkish clocks are turned ahead one hour from late March to late September for daylight saving time. Customs agents spot-check bags on departure. Enforcement is strict and penalties are severe. Be sure to inquire about rates and surcharges at your hotel before you call.