Cyclooxygenases catalyze the conversion of arachidonic acids to prostaglandins. Both work equally well, but Naproxen causes ulcers. Ro 31-7453 is an orally active cell cycle inhibitor and apoptosis inducer. The inhibition of the cell cycle by Ro 31-7453 is reversible for some time simply by washing out the drug. The drug works in a wide array of in vivo cancer models, causing regression of the tumor in some.
Toxicity is seen in the bone marrow, lymphoid organs, intestines, liver and testes.
The toxicities were reversible upon cessation of treatment. Two active metabolites are formed, each of which form inactive secondary metabolites. One of these metabolites is formed by hydroxylation of one of the methyl groups. HER2 Targeted Monoclonal Antibodies Robert Mass, Ph. D., Genentech. It s over expression correlates with poor survival.