These tumors occur twice as frequently in females as males. Signs include bilaterally symmetric hair loss, usually starting at the tail base and progressing up the body. There may be a history of hair loss and spontaneous regrowth. Itching is often reported as well as dryness of the skin. An enlarged vulva may be present in females, loss of muscle tone and weakness may be present.
Treatment involves surgically removing the tumor.
Adrenal tumors are rarely metastatic. The most commonly affected organs are the spleen, liver, and, lymph nodes of the chest and extremities. Clinical signs are dependent upon the organs affected. Signs include weight loss, enlarged spleen, lethargy, difficulty breathing, enlarged lymphnodes, and skin tumors. Ferrets have dramatic seasonal changes in the hair coat length, thickness, and color triggered by photoperiod changes.