The British medical profession has accepted George III as a bona fide case, on the basis of his symptoms. Prince Charles is reported to believe that it exists somewhere in the extended royal family today. Rumors have circulated that the royals have had themselves tested, but there is no evidence for this, nor is there any evidence of any symptoms of porphyria in living family members. The range of severity of a disorder among those who manifest it. Since porphyria is an autosomal dominant trait, one of George III's parents must have had the mutation, but there were no discrete symptoms.
Some historians think so.
James I, Mary's son, was known to fly into irrational rages. His daughter, Elizabeth, married the King of Bohemia, thereby starting a long series of marriages with German nobility and a German branch of the royal family that at least equals the British branch in size. He also forged the Prussian Army that later unified the German Empire. George's children Of George III's 15 children, seven or eight should have inherited the mutation, according to Mendelian predictions. Most of George's 13 surviving children, including George IV and Edward, Queen Victoria's father, seem to have had porphyria-like symptoms, though it is difficult to make a diagnosis against a background of other illnesses.