Computer analyses indicated that all these 20 bp sequences are the bend centers in the long stretch of AT-rich DNAs. This is strikingly similar to our findings in the bacterial model system. It appears that DNA bending may be an important regulatory element conserved for the control of gene expression in all species including human. To explore this possible mechanism, genetic, biochemical, and biophysical approaches are employed. Pharmacologically, the identified DNA structural elements are potentially important therapeutic targets for providing treatments to many genetic diseases.
Transcription generates positively and negatively supercoiled domains in the template.
A promter relay mechanism for sequential gene activation. AT rich DNA sequence element functions as a bacterial gene silencer J. Biol.