The single cells show large, hyperchromatic nuclei, prominent nucleoli and scant cytoplasm. The intervening stroma contains inflammatory cells. The presence of some tubular structures makes this a poorly differentiated adenocarcinoma. The tubular structures are not as well developed as they would be in a well differentiated adenocarcinoma, but are nevertheless present. Undifferentiated carcinomas do not have glandular structures.
Undifferentiated carcinomas require immunohistochemistry to help in making the diagnosis.
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