There is no guarantee that an experimental treatment will help. Some trials require that you stop current treatments. If you are stable on your current regimen, changing it is probably unwise. On rare occasions these unanticipated side effects can be serious, and on very rare occasions they can even be life-threatening. Clinical trials that entail significant costs to participants should generally be avoided.
Trials can be inconvenient.
They usually require extra visits to the doctor's office or to a clinic or hospital. Some may even require you to be admitted to the hospital for a time. Ask if any of these costs are covered by the trial. Trials can be unpleasant. They may require that you undergo a lot of tests, and these tests may be uncomfortable or even painful.