The disease is usually chronic, with repeated periods of flare-ups and remission. There is also an appreciable increase in frequency during fifth and sixth decades of life. Although all ethnic groups may develop the disease, it is most prevalent among people of Jewish descent. The exact cause of ulcerative colitis is unknown. The disorder may be related to an autoimmune factor or immunological agents, or it may be caused by an unknown environmental agent.
Ulcerative colitis seems to run in families.
A family member of a person with inflammatory bowel disease has an increased risk of developing the disease, suggesting a genetic predisposition. Stress may aggravate the condition, but it is not considered a cause. For more information on ulcerative colitis or other autoimmune disorders, please click on the request information icon below. It is vital that persons diagnosed with, or suspected of having, an autoimmune disease consult with their physician or with the appropriate division at a major teaching hospital, to assure proper evaluation, treatment and interpretation of information contained on this site.