If this is not your name, click here. Other Ophthalmic Surgery Organ Transplantation Orthopaedics Other Osteoarthritis Osteoporosis Otitis Otorhino. The study was conducted by Dr. Marcia R. Cruz-Correa, a clinical fellow, and her colleagues at Johns Hopkins University, Baltimore, Maryland. Other studies followed showing similar results. Why sulindac reduces the number of polyps in FAP is not really known.
Some studies suggest apoptosis.
The Johns Hopkins team conducted this study to determine the long-term efficacy and safety of sulindac in this patient population. Twelve FAP patients who had undergone ileorectal anastomosis and had rectal segments free of adenomas were enrolled into the trial. Doses of drug were adjusted to determine the minimal effective dose for reducing polyps. Every four months, the investigators assessed the number, size, and histologic grade of any polyps that appeared, and assessed medication side effects and patient compliance. Compliance with drug treatment was excellent and the most common side effects were relatively mild, Dr. Cruz-Correa said.