In trouble with the law, with society, with your family, neighbors, and friends. Into drugs, alcohol, or gambling. Troubled in conscience, heart, and mind.
Trouble is common to the flesh.
All of our sorrow, trouble, and difficulties come from one problem - we are in trouble with God. God is truth, God is life, God is light, God is love, and God is our hope and peace. If we have not God we have none of these things. Because of our sins we are without God, without help, and therefore without hope in this world. Man hasn't always been in this condition.