Hailey-Hailey disease is a dominantly inherited disorder that may resemble pemphigus vulgaris and begins in the second or third decade of life. Intertriginous areas such as the axillae, the side of the neck, and the groin are typically involved.
Spontaneous remission followed by exacerbation during the warm season is characteristic.
The differential diagnosis includes pemphigus vulgaris, pemphigus vegetans, subcorneal pustular dermatosis, and Darier's disease. In contrast to pemphigus vulgaris, no circulating or tissue-bound antiepithelial antibodies have been detected by immunofluorescence testing. Treatment includes topical and systemic antibiotics and topical glucocorticoids.