Aggression tends to be a problem encountered in certain breeds more than others. Pure psychotic aggression, in my opinion, cannot. Always seek professional help with aggression. Abnormality seems to be psychological. The animals I have seen seem to be almost autistic.
Some dogs are non-responsive, while others just seem depressed.
In many cases the dog has developed this way from either a series of negative experiences during development, or it is in an improper household and just shuts down the dog emotionally. There are human social styles that correspond with the dog social styles and that can help with pairing dogs and owners. Most savvy breeders will do this for you so ask for their help in selection. In the wild animal field, zoological gardens have just been acknowledging the useful tool training can be for their animals. Unfortunately they have swung from the far side of the spectrum of not handling the animals to the other, which is that you should control them through operant training.