Get the best daycare you can afford so you won't be wracked with worry while you work. Stagger shifts with your spouse. If one works days and another works nights you'll never need daycare. I know couples doing this and they like it. Often the charges decreas as a child gets older.
Some providers give a discount for more than one child.
You and your provider share a powerful responsibility in caring for the children. It is important to have a good relatioship. So, our most expensive time with 2 kids three years apart was when the older was a 3-4 year old toddler and the younger was an infant. For that kind of money, we could have had a very good nanny at home if we'd found one we liked. Without a discount, it would more than double.