The structural relationship between the thymic peptide and the antigen-derived peptide is a fundamentally important and yet unresolved issue. Control and induction of autoimmunity. During the past year we rigorously investigated the popular hypothesis that antiMBP TH1 cells are encephalitogenic while TH2 cells are protective. Our data indicate that the differential effect of antiMBP TH1 vs TH2 cells seem to stem more from differential homing capabilities of these T cell subsets rather than differential cytokin production. Xu, M., Moratalla, R., Gold, L.H., Hiroi, N., Koob, G.F., Graybiel, A.M., and Tonegawa, S. Dopamine D1 Receptor mutant mice are deficient in striatal expression of dynorphin and in dopamine-mediated behavioral responses.
T lymphocytes in normal mice.