Avoid overuse of your thumb when using a trackball. Use caution before purchasing a trackball that uses the thumb to roll the ball. If your work requires repeated button clicking, try using a trackball that requires low force levels to activate the button. The KeytronicsTrak 101 keyboard allows the user to program keys to use as buttons. The left hand can be used to activate the button, while the trackball is operated with the right hand to divide work between both hands.
Trackballs are available with foot pedal options to reduce the load on the fingers.
Drag-lock features are available on most trackballs. This option allows you to click on an object and hold without depressing the button. The held object can be released when a second click is executed. Select a pointing device that is the right size for your hand. A painful ring or little finger may result from a pointing device that is too large or too small for you.