The presence of oral lesions indicates systemic CMV involvement that necessitates intravenous therapy with gancyclovir. NUP is characterized by rapid localized destruction of alveolar bone and periodontal tissue. Petechiae-like patches on the attached gingiva often are associated with spontaneous gingival bleeding. Necrotizing gingivitis has a clinical appearance of localized cratering and necrotic ulceration of interdental papillae and marginal gingiva. In the actue stage, the alveolar bone is not involved.
Treatment involves scaling of affected areas and debridement of necrotic tissue.
The use of antibacterial mouthrinses is often helpful. Systemic antibiotics are effective in managing NUP and necrotizing gingivitis. Home care and systematic followup are very important. 2 tablets immediately, then 1 tablet 4 times per day. Neoplasms Oncogenic viruses probably are rendered more effective by failure of some part of the immune system, such as the tumor-surveillance mechanism.