When a potential signal is detected, various actions may occur. This may involve a search for similar cases in other databases such as the WHO database. The WHO Programme on International Drug Monitoring, in which Canada is a participating country, pools reports from over 50 countries in one database. This pooling of data enhances the ability to compare and identify trends in ADR profiles, and to identify rare, serious, unexpected reactions as early as possible.
Signals are essentially suspicions.
Assessment of all available data is required to improve rational decision-making in pharmacovigilance. Therefore, a good quality case report is important for the ongoing surveillance of drug safety. Principles of signal detection in pharmacovigilance. Edwards R, Biriell C. Harmonisation in pharmacovigilance. Wood S. Spontaneous reporting outside the United States.