Autoimmune diseases can be life-threatening without prompt medical attention. Pemphigus is characterized by production of antibodies against the intercellular cement substance of the skin. Frequently affected areas include the gums, lining of the mouth, nasal region, the facial zone, nails, and surface of the skin. The loss of intercellular cohesion leads to the formation of blisters within the affected skin layer. Veterinary treatment of feline pemphigus can be difficult, requiring large doses of glucocorticoids, with or without other, more potent drugs.
Side effects can be severe, and close physical and laboratory monitoring of the patient is critical.
Often, therapy must be maintained for the life of the animal.