A systemic retinoid, approved only for recalcitrant cystic acne. Systemic retinoic acid derivatives are also demonstrating efficacy in the treatment of adult T cell leukaemias. A systemic retinoid that is used in psoriasis. Its warnings and precautions are the same as those for isotretinoin. A topical retinoid used in the treatment of Kaposi's sarcoma.
Side effects are similar to the other retinoic acid derivatives.
NOTE that patients with T-cell lymphoma are less responsive. The recommended dose is applied twice daily, but application may increase or decrease dependent upon the patient. Also NOTE that if the patient has more than 10 new lesions monthly or if systemic lesions appear, then alitretinoin therapy is inappropriate. These agents selectively digest necrotic soft tissues by proteolytic actions. They dissolve and facilitate the removal of necrotic tissue and purulent exudates that impair the formation of granulation tissue, which would delay healing.