Spread it over the stained area. Leave to sit for about 2 hours. Then, wash the shirt in the normal wash. To remove the smoke smell out of clothes, add a cup of vinegar to a bath tub of hot water and hang the clothes above the steam. About every 6 months, poor a gallon of bleach in and run it through the complete full load cycle.
Some people use a cup of bleach once a month.
Also a gallon of vinegar can work. It's supposed to be good for the machine and your drains. If you have hard water at your house, instead of spending lots of money on a water softener, buy a bag of water softener salt and throw 3 or 4 rocks into the washing machine with your laundry. Your water will be soft and your clothes will be cleaner. To remove felt tip pen stains, rub the stain with soap and a toothbrush.