There is some mild proliferation of bile ducts. For the most part, these are unremarkable, although a small amount of bile duct damage is seen. Only a few central veins are present and appear normal. The hepatocytes show moderate macrovesicular steatosis. Ground glass hepatocytes and inclusions are not seen.
Some areas have somewhat of a reactive appearance with larger binucleate forms present.
Mallory's Hyaline is not seen. In addition to the above fibrosis, a focal small amount of sinusoidal fibrosis. Reticulin stain indicates that the sinusiodal architecture is preserved in the majority of the biopsy with thickened and irregular plates present in one of the biopsies. Pas positive inclusions are not seen and iron stains do not demonstrate parenchymal iron. Overall the liver biopsies show a chronic hepatitis with mild piecemeal necrosis and severe fibrosis, bordering on early cirrhosis in some portions.