Most produce a mucus-like substance that may be seen in the urine. Primary Vesical Adenocarcinoma commonly affects either the bladder base or dome. Like SCC, primary vesical adenocarcinoma may arise after long-term irritation and inflammation, and it may occur in some individuals who have been infected with Schistosoma haematobium . Most primary vesical adenocarcinomas are locally aggressive and invasive. Patients often have poor prognoses and do not respond well to radiation therapy or chemotherapy because their tumors are diagnosed too late.
Urachal carcinoma is a rare tumor that affects the outside of the bladder.
Like primary vesical adenocarcinomas, urachal carcinomas usually do not respond well to radiation therapy, chemotherapy, or surgical therapy. Metastatic adenocarcinoma is a rare bladder tumor caused by cancer cells that have broken off from a primary cancer somewhere else in the body. Before metastatic adenocarcinoma is treated, the patient must be evaluated to detect the primary cancer and any other metastatic tumors that may be present. If small cell carcinoma of the bladder is confirmed, the patient should be evaluated for a primary lung cancer. Primary small cell carcinoma of the lung may have metastasized to the bladder and may look like undifferentiated carcinoma.