We become human doings instead of human beings. We lose our sense of self. We get so busy running here to there, when someone gets in our way they become an impediment to our doing. We've gotten on a treadmill. We spend a lot of money doing lots of things, and we've grown up with this sense that it's almost necessary to do that.
Stress takes an enormous physical toll.
Our bodies react to stress with an instinctive adrenaline surge. It also accelerates the development of heart disease, and increases the risks of developing blood clots. This explains why individuals subjected to an acute stressful event can have a heart attack. We can look at it with a blood test. Many symptoms of stress mirror the symptoms of depression.