If you have a history of heart trouble or swelling in the legs, consult your doctor because glucocorticoids may affect such conditions. You may feel nervous and have trouble sleeping, especially if you take your dose later in the day. If you have a history of serious mental health problems, consult your doctor about how to deal with these risks. Occasional Side Effect Occasional side effects may occur in people who take glucocorticoids for weeks to months, especially at moderate to high dosages. Information should be discussed with your medical team to review all aspects of the medications.
Side effects do occur in some people taking methotrexate.
At the low weekly doses used to treat rheumatoid arthritis, however, serious side effects are rare. The most common side effects include upset stomach, nausea, vomiting, loss of appetite, diarrhea or mouth sores. If these develop, you should contact your doctor immediately. A change in the dose or in how you take your methotrexate may reduce these side effects. Occasionally, side effects such as headaches, dizziness, mood alterations, skin rashes or unexplained weight loss may occur.