Massachusetts Institute of Technology, Cambridge, Massachusetts 1983 - Present. The Johns Hopkins University, Baltimore, Maryland 1997 - Present.
Structure is determined, essentially, by the underlying amino acid sequence.
As the gap between the number of known sequences and known structures continues to widen, interest in computational methods to predict structure from sequence has heightened. The native structure is expected to be that of minimum energy and the problem is locating this minimum in the high-dimensional, rugged space defined by the possible polypeptide geometries. Specifically, our work is directed at developing a molecular model of the peripheral-type benzodiazepine receptor and an automated procedure for the prediction of its interactions with cholesterol and other hydrophobic molecules. The peripheral-type benzodiazepine receptor and adrenal steroidogenesis. Wake Upsets, AIAA Journal of Aircraft, V11-3, March 1974.