If the notebook will be a substitute for a desktop PC, a heavy one with all the bells and whistles would probably be the best choice. If it is to be shared by many users for a few hours at a time, legacy ports, a floppy drive and a CD-ROM drive may be unnecessary. And if a notebook PC is for traveling, especially by air, weight will matter, as will the ability to swap devices such as a floppy drive, or a second or even third battery. But the buying rules are different for computers that will be carried through airports than from computers that will sit on sturdy desks. Even if money is no object, weight and battery life always are.
Some choices are easy.
A 12G hard drive is almost always a better choice than a 6G drive because it won't really weigh more. Memory size and the power it uses also are important. For notebooks, higher clock speeds kill battery life. If you max out on power-hungry options, even those that don't weigh much, it might mean carrying an extra battery, and that's a lot of extra weight. Screen size isn't an easy choice, either.