Increase the dose deliberately till mood returns to normal. As you proceed, keep your doctor informed about your dose and your mood to get the best possible guidance in your search for the best dose. Families often know before the MSer does, when the right dose has been reached. Behavior changes dramatically when blood and tissue concentrations reach a therapeutic level. But even after depressed behavior has ended, depressed thoughts linger.
Thoughts are still depressed.
The person may still be mulling over inconsequential events from the past but does not recognize that these thoughts are no longer accompanied by the temper tantrums of a few weeks ago. It often takes another two to six weeks before the MSer realizes that Depression has disappeared. It is important to remember the delay between improved behavior and improved thought. The family is the first to know when the dose is right. They are the only accurate barometer of future blue skies or storm clouds.