Selenium Metabolites Selenium Metabolites Certain Astragali act as accumulators of selenium. Selenium is a required mineral for most animals.
Toxicity tends to be chronic and result in alkali disease and blind staggers .
When intake exceeds excretion for a long enough period of time, toxicity occurs. Its highest tissue concentrations are found in the liver, red blood cells, spleen, heart, nails and tooth enamel, implying that during toxicity this is where most damage will occur.