If virologic failure is confirmed, a new regimen is chosen and prescribed at the first visit after resistance test results are available. If virologic failure is not confirmed, the current drug regimen is not changed. Otherwise, on-site study visits occur every 4 weeks until Week 24 and then every 8 weeks thereafter through Week 48. Quality of life is assessed at baseline and then every 16 weeks through Week 48. Currently be virologically failing their second, third, or fourth antiretroviral regimen which includes 3 or more drugs in combination.
Virologic failure is defined based on viral load criteria in the protocol.
Have written consent of a parent or guardian if less than 18 years old. Stable current 3 or more drug combination antiretroviral regimen for at least 8 weeks before study entry. Brief use of corticosteroids for Pneumocystis pneumonia or asthma. Hydroxyurea or adefovir, including at a time when they were investigational. Brief use of corticosteroids for Pneumocystis pneumonia or asthma.