If this should happen the structure and shape of the enzyme is altered so drastically that the active sites no longer can accept the substarte molecules because of their distortion. Changing the pH disrupts intramolecular binding forces that keep the enzyme in a specific shape. Disrupting those forces will unravel the protein and render the active site distorted. We have already discussed how competitive inhibitors can affect the enzyme activity. Toxicology and Enzyme Inhibition Toxicolgy is the study of toxic agents.
Toxic agents is a little disceptive.
Most people think of something that is toxic as something that will cause certain death. This is not always the case. Toxicity depends on a number of factors. The body weight of the organism has to be considered. The tolerance level of the toxin in the organism is a factor.