If inflammation persisting for months of years due to the wound being chronically sealed by necrotic tissue, is contaminated with pathogens of foreign material that cannot be phagocytized. Epithelialization Mobilization of the epidermal cells. Epithelial cells migrate from the border in a leap frog fashion or in a train like fashion. Must have a free edge. Provides a protective barrier to prevent fluid and electrolyte loss and reduce the chances of infection.
Wound contracture is initiated during re-epithelialization.
Pulls the edges together. Which are responsible for wound contraction. Collagen synthesis - The integrity of the wound depends upon this. They secrete the substance known as ground substance as well as lay down collagen to support the neovascularization and to fill the space. Endothelial cells will then form buds at the end of the intact capillaries and grow into the wound joining others to form a capillary network.