They are not a cure, they merely treat the symptoms. They all have side effects, some of which can be worse than the reflux itself. I highly recommend altering your diet before trying the medications, and consider performing medical tests before trying medications. Some people have had success with alternative medicine. As with anything, you should always research anything you're considering and talk to your doctor about it.
Slippery elm is an herbal remedy that has helped many adults and babies.
Chiropractic adjustment has been known to be helpful for some babies, but be sure to find a practitioner who is experienced in working with infants. Cranio-sacral therapy is another option. Homeopathic remedies are a safe, often effective treatment, too. Check your local health food store, but consider consulting a homeopathic doctor for a more specialized treatment. Acid-Ease is another herbal remedy that has been helpful for some babies.