Block uptake of norepinephrine into the central nervous system synapses. Increase HR, may cause hypotension. Increase HR, decrease BP or stable, increase risk for arrhythmias. Blocks beta-receptors of the sympathetic nervous system.
Some agents act primarily on beta receptors in the heart.
These are called cardioselective. Beta- blockage results in decreased heart rate, blood pressure, and contractility of the heart. Therefore, reducing the demand for oxygen by the heart. Angina pectoris, hypertension, previous MI patients, arrhythmias, migraine headaches. May increase HR, may produce arrhythmia, BP effect will vary.