All patients were followed at three-month intervals for at least six months, and advised to return if any occurrence was noted. Average follow-up ranged from two to thirty months. Postoperative urethral meatal calibration failed to reveal any stricture formation in patients with distal urethral and meatal lesions. Erythroplasia of Queyrat has been followed after CO 2 laser vaporization for thirty-six months and fourteen months respectively, with no recurrence. Comment Condyloma acuminatum has been considered by many to be a disease of minor importance, even though it may be a premalignant lesion and could assume major proportions.
Successful treatment requires accurate determination of the location and extent of involvement.
Although the efficacy of this modality is well appreciated, our personal experience has been disappointing since patients tend to complain of severe pain and irritation in the perimeatal and distal urethral region which prompts discontinuation of treatment. In 1982 we reported on the guidelines for the treatment of condyloma acuminata 7 with CO 2 lase with successful eradication with one single treatment in 96.6 per cent of 22 cases treated. In 1975, Dretler et al. 12 reported on the use of topical 5-FU recommending a twice daily application, preferably under foreskin or condom occlusion for a period of four to five weeks. Marked erythema, edema, burning, and stinging required temporary discontinuance of therapy. In 1980, Rosemberg et al. 9 reported on the first case of erythroplasia of Queyrat successfully treated with CO 2 rapid superpulse laser, with complete disappearance and excellent functional and cosmetic results.