There they may be swallowed and have an opportunity to infect the GI tract as well. Eyes, including lacrimal glands 4. Genital tract, both male and female 5. Local spread in the sub-epithelial connective tissue . This tissue normally has a gel-like consistency, making it harder for microbes to move through it.
Some organisms can liquefy it by producing hyaluronidase.
Streptococcus pyogenes 2. Spread via the lymphatic vessels A. Extracellular fluid is normally drained by the lymphatic system. Therefore, any microbes present in the extracellular fluid are likely to be carried into the lymphatics. From the peripheral lymphatics, the microbes go through the nearest regional lymph node. If not sequestered in that node, they may go through other nodes, and ultimately to the thoracic duct.