20-30 mls clear, fresh, sterile amniotic fluid. Analysis of at least 20 metaphases for numerical and structural abnormalities, and preparation of 2 karyograms. 7-15 days turnaround Analysis of at least 60 metaphases for fragile X using two induction media. Includes karyotype analysis at the 400-600 band level of 20 additional metaphases for numerical and major structural abnormalities, and preparation of 2 karyograms. Bone marrow specimens are more desirable, but when it is not possible, this test may be substituted.
Success is contingent on the presence of mitotic immature granulocytes in the peripheral blood.
Analysis of at least 50 metaphases from each treated and untreated culture for both the patient and a control. Metaphases are scored for chromosome breaks and rearrangements. This test does not include full karyotype analysis, but will detect major structural abnormalities. 1-6 days turnaround Karyotype analysis of metaphases from direct and 24 hour harvests of bone marrow. Analysis of at least 20 metaphases for numerical and structural abnormalities and preparation of 2 karyograms.