The cardiac stimulating properties of sympathomimetics can aggravate the cardiac symptoms of hyperthyroidism. Also, central nervous system stimulation causes an increased secretion of thyroid hormone which is potentially dangerous to a hyperthyroid patient. Antidepressants Oral decongestants are contraindicated in patients taking MAO inhibitor antidepressants. Concurrent use may cause cardiac arrhythmias, severe hypertensive crisis and even death. A two week wash out period is required for MOA inhibitors and 2 days for moclobemide.
Tricyclic antidepressants facilitate and increase the sympathomimetic response of phenylephrine.
Increased cardiovascular eflects can lead to arrhythmias, tachycardia and hypertensive crisis. Phenylephrine should be avoided by those taking tricyclic antidepressants. Hot fluids seem to work better but avoid those containing caffeine. Increase humidity with humidifiers or vaporizers. Take frequent showers and keep the door closed to increase humidity.