The vaccine may be considered for persons in areas of high or moderate risk but whose exposure to tick-infested habitats is neither frequent nor prolonged. ACIP recommendations for the use of Lyme disease vaccine were published in June 1999. Maximum protection from the vaccine requires three doses. The first two doses are given a month apart, and the third dose should be given 11 months after the second. Ideally, all 3 doses should be completed one month prior to the anticipated tick-exposure.
Studies are underway.
The need for booster doses has not yet been determined. Studies are ongoing. The safety of Lyme disease vaccine administered during pregnancy has not been established. Vaccination of women who are known to be pregnant is not recommended. Lyme disease is the most common insect-transmitted disease in the United States.