To prevent evaporation from the skin use products suggested above. Do not use scrubbing devices to scrub off dead skin cells as these act as barriers. It takes two weeks for a new skin cell to go from the basal layer up to the dead skin layer. When the barrier is removed, moisturizer needs to be applied. If prone to cuts and nicks, use the steri-stripping method rather than sutures.
Some patients become sensitized to the hormones through topical application.
It has not been shown that HRT will increase the collagen level to baseline levels, but approach the level before menopause. HRT can begin when menopause starts. Therefore HRT also increases bone density as well as collagen levels throughout the body. Skin collagen content has also been found to correlate with uretheral pressure.