Hypersensitivity reactions caused by wine can also be related to chemical additives or histamine. The origin is not clear but it may have come about as a hybrid of the pomelo tree and sweet orange. Tangelo is a hybrid product between grapefruit and orange. It originated in China 4000 years ago and may have resulted from insect born pollination between pomelo and mandarin orange. Grapefruits are eaten fresh, processed into juice and canned.
Tangelos have a less bitter taste than grapefruit.
These authors found that the fruit allergens tested, including lemon, had a high correlation with each other. The fruit originated from Latin America and was a favourite food of the Aztecs and Incas. It is cultivated in the southern US and has been introduced into West Africa. It grows on a low growing, bushy tree with fragrant flowers. The sweet yellow fruit from some varieties is eaten fresh.