An initial biopsy is undertaken to determine the diagnosis. Chemotherapy is often then administered prior to definitive surgery in an attempt to make the surgical resection easier. The tumor response to chemotherapy has prognostic significance. Chemotherapeutic agents commonly used in the treatment of osteosarcoma include methotrexate, adriamycin, cisplatin, ifosphamide, and other agents. Several of these medications are often given in combination.
Surgical management requires complete removal of the tumor with a margin of normal tissue.
Two main surgical approaches are used, amputation and limb-salvage procedures. The choice of technique must be individualized and is based on the ability to obtain a complete tumor resection as well as functional considerations. The information provided through OncoLink should not be used for diagnosing or treating a health problem or a disease. It is not a substitute for professional care. If you have or suspect you may have a health problem, you should consult your health care provider.