When you register at the convention, you'll receive a program guide, and a schedule of videos and events. If you're feeling industrious, work out your whole weekend schedule. Descriptions of all the videos, panels, and events can be found in the program, so look up info on something you are unsure of. Taking a little time early to plan ahead will save you more time later, and you'll miss less stuff. It gets the prime Saturday evening time slot, and it is probably the most heavily-attended event at the convention.
Some people line up hours in advance to get good seats.
Two other events we suggest are Mystery Anime Theater 3000, and the Music Video Contest. These are also very heavily attended events, and are always fun to watch. For those who like music, there is a dance on Saturday night featuring dance, anime, and techno music. The con suite is a mystery to some newcomers. What it is is a room you can go to to relax, sit on a nice comfy soda, and eat free food and soda.