If you have only one vehicle, it is best to park it near the trailhead where you exit the canyon. Be sure not to drive off-road, block another vehicle, or otherwise obstruct traffic when you park. The Bright Angel Lodge offers a storage service for valuables for a fee on a space available basis. The canyon is home to a variety of snakes and scorpions, some of which are poisonous. A good rule to follow is to always be aware of where you place your hands and feet.
Snakebites are rare, occurring mostly when people attempt to handle snakes.
Do not attempt to capture or otherwise molest any wildlife. If bitten, contact a ranger by signaling or sending someone for help. Although snakes often do not inject venom when they bite, any animal bite should be examined by a physician and monitored for signs of infection. Scorpions are common in the canyon and stings occur with regularity. While scorpion stings are painful, they rarely cause serious health problems.