Keep the tablets out of light, somewhere cool. Use under medical supervision. The manufacturing of SAMe is a difficult process involving substantial costs. Do not use it to treat manic depression or severe depression. All depressed patients should seek advice from their physician before using any drugs or supplements.
Side effects are rare and mild.
These may include gastric upset with nausea and vomiting. If used at high concentrations it may also cause dry mouth, restlessness and, rarely, anxiety. Reducing the dose usually helps avoid these side effects. SAMe methylates molecules within neurons and keeps these in active condition. It is a valuable agent in treating depression and other age-related diseases.