They have a strong since of curiosity and once out, they will sniff and investigate until they are totally lost. Make sure there isn t any way for him to get outside. Check out dryer vents, heat vents, pet doors, there are numerous ways for a little skunk to get out. It is extremely rare that a lost skunk is ever found. Other things you need to do to skunk proof your home is to put child proof latches on all the cupboards that could contain dangerous materials or things you don't want the skunk to get into.
Skunks love to dig, keep the potted plants out of reach.
Look around at your low tables. Skunks front feet are very much like hands, they have quite the reach on them and can pull things down from tables and get injured. Make sure the skunk has plenty of fresh water available to him at all times. Skunks need a very nutritious diet. Feed them fresh, cooked and raw vegetables that are washed.