Thus, if the two occur together, the combined effect would be greater than the sum of either occurring alone. It is a phenomenon well known in pharmacology, but it does not appear to have been seriously considered in connection with fluoride from the medical point of view. A large number of pesticides, chiefly organic phosphates and carbamates, act in the body by blocking this enzyme action, thus allowing excessive amounts of the muscle stimulator to accumulate. Once fluoride has been absorbed by the blood it is dispersed rapidly to all of the body's organs. Approximately one half is stored in the skeletal tissues.
Some fluoride is deposited in the teeth while they are calcifying.
The mechanism involved is the replacement of hydroxyapatite by the less soluble fluorapatite in the crystalline structure of tooth enamel. Reprinted from the Santa Clara Lawyer, Vol. Existing data indicate that subsets of the population may be unusually susceptible to the toxic effects of fluoride and its compounds. Impaired renal clearance of fluoride has also been found in people with diabetes mellitus and cardiac insufficiency. Fresh or unprocessed foods available in the U.S. have fluoride concentrations to 2.0 ppm.