Ultimately the parasites invade the brain, causing first behavioral changes such as fear and mood swings followed by headache, fever, and weakness . Simultaneously the patient may develop myocarditis . Death may occur within 6 months from cardiac failure or infection if the person is infected with rhodesiense. Gambiense infection may require up to 2 years before symptoms of infection in the central nervous system appear. Gambiense-infected people develop drowsiness during the day but insomnia at night.
Sleep becomes uncontrollable as the disease progresses until the patient becomes comatose .
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