In addition, when agents are administered at convulsive doses the animals not sacrificed following the convulsion regain consciousness after the convulsive event within minutes. Such situations are accompanied by a high degree of stress and discomfort for the animal. Antimicrobial Prophylaxis and Therapy Registration and regulatory authorities require antimicrobial agents to be tested routinely in animal challenge models. Therapy of Septic Shock Septic shock is a major cause of death in patients in intensive care units. The protective activity of substances against septic shock is tested initially in a pharmacological animal model.
Septic shock is induced in experimental animals e.g. by the application of endotoxin.
Animals are also used in research on reducing pain in septic shock victims.