For me the hardest part is the way my body reacts to medication. I find one that works, and over time it stops as my body becomes accustomed or resistant to it. Then we either increase the dose, add a second med, or change them all together. Sometimes I feel like a walking pharmacy. Well, meds help, when they are working as they ought.
Therapy is good too.
But for me, support has been the best of all. Actually, I have found the medical field to be supportive of treating depression. Unfortunately, I think a lot of general practitioners prescribe antidepressants to quick and too much. My doctor didn't know that grinding your teeth is a side effect of Zoloft-a very commonly prescribed drug. I lone her.