Signs can be respiratory distress with a purulent nasal discharge. Generally these are problems with the upper respiratory tract. This material is highly infectious to other birds. If left untreated this can be fatal. In most situations swabbing the birds prior to treatment to obtain a culture and sensitivity result is a very wise move.
Treatments used are varied.
In most cases fanciers prefer to use antibiotics that are effective against the Mycoplasma. Latently infected birds and failure of a response to treatment can be seen. Some birds will not imbibe sufficient water to achieve therapeutic success. All of these are effective against the Mycoplasma. The second bacterial infection is of concern in many species and has human health implications.