My mother who is in her mid-seventies is going through a deep depression in addition to electroshock she is being given thorazine. It seems to help. Thorazine is a major tranquilizer, used to suppress agitation and thought disorders. It is usually used after lesser strength drugs have been effective. This is an involuntary smacking of the lips and grimmacing which is completely irreversible once it occurs.
Some patients also experience malignant hyperthermia.
This is uncontrolled temperature regulation of the body and can be fatal. This usually occurs right away or not at all. But, occasionally will occur after time on the drug. Thorazine is a major sedative used to treat psychosis generally. I was having a severe reaction to the Septra and an itchy beet red rash all over my body.