Of course, the primary things that are going to offend the Holy Spirit are the things that are unholy. When we think of unholy we usually think of sexual lusts and perversions first. Undoubtedly these are offensive to God, and the Scriptures are clear that the wrath of God will come because of them. And be kind to one another, tenderhearted, forgiving each other, just as God in Christ also has forgiven you. God is love, and anything that is not done in love does grieve Him.
Sexual sin is a sin because lust is the counter-power to love.
Sex was created for love, not love for sex. However, all of the counter-powers to love, such as bitterness, wrath, anger, slander, malice, grieve and offend the Holy Spirit. If there is a resolution that we make for this coming new year, let it be to be filled with the Holy Spirit, to walk in the Spirit, and do nothing that would cause the Spirit to depart from our life. Before the end there will be a people who walk and abide in the Spirit. Because they walk in love they will be entrusted with unprecedented power.