With ecstasy and amphetamine the rush can make people want to dance and never stop. Depressant drugs, including alcohol, dull the central nervous system so the heart beats more slowly and this can give people a feeling of well-being, relaxation and loss of inhibitions. Drugs with hallucinogenic effects take an hour or so to act and they change the way people see the world. These drugs can take hours to wear off. It's asking for big trouble to take any drug unless you're sure what it is and where it's come from.
Stimulants can cause overheating and dehydration.
And, remember, every time you go up you have to come down and the comedown can be nasty. How you'll react to a drug depends only partly on what's in it. But reactions to the same drug can also vary from time to time and in different situations. If you're somewhere you don't like or with people who make you feel uncomfortable, you're more likely to have a bad experience. And the higher you go, the harder you fall.