Rarely, cases are complicated with meningoencephalitis, myocarditis, pulmonary edema and death. Exclusion from school is generally not required. Good hand-washing technique is necessary to reduce potential spread of disease. Do not rupture blisters to reduce viral spreading. Lower lip shows an ulcer with erythematous halo.
Tongue shows ulcer with erythematous halo.
Classic cutaneous lesion shows a elliptical vesicle surrounded by an erythematous halo. Long axis is oriented along the skin lines. The Exanthematous Diseases of Childhood. Medicine is a constantly changing science and not all therapies are clearly established. New research changes drug and treatment therapies daily.