No surgical pathology report is received with the specimen. The specimen consists of a fragmented needle core biopsy of liver. The normal lobular architecture appears intact and that the normal spacing between portal tracts and central veins is maintained in most areas. However, in some regions, there is a vague intralobular nodularity and thickening of the plates, suggestive of mild focal nodular regenerative hyperplasia-type changes. This impression is confirmed on the reticulin stain.
Trichrome stain shows minimal focal portal fibrosis.
The portal tracts show mild mononuclear inflammatory cell infiltrate with minimal evidence of duct damage and only focal mild interface activity. The Kupffer cells appear to contain a slight increase in iron pigment. No definite viral inclusions or ground glass cells are seen. In addition, there are mild focal nodular regenerative hyperplasia- type changes. This can be related to the viral disease, or has been described in association with azathioprine therapy in liver allograft recipients.