Check the alignment of your wrist, and then set at the angle of the keyboard as needed. If you use a keyboard tray, it should be wide enough for your pointing device. Wristrests can be used to provide neutral wrist position. Make sure the wrist rest is the proper height and is made of a comfortable material. Wrist rests come in all shapes and materials.
Smooth surfaces are often easier to glide across when working.
If you use a wristrest, use the wrist rest to support your arms when pausing between keying. Do not place your wrists on the rest and turn your wrists from side to side to key. This increases the strain on your wrist. Your pointing device should be positioned within easy reach.