Click here for homepage. He worked at The University of CA, Santa Barbara as an assistant professor for 6 years and at Cornell University in Ithaca, NY as a research associate for 3 years. He joined the faculty at University of Memphis in 1976.
Signal transduction is studied using platelets from knockout mice and human platelets.
A scanning electron micrograph of a resting platelet Approximately 2 m in diameter in the resting state, platelets do not exhibit homeotypic cell-cell aggregation or adhesion to the vessel wall. A platelet is an anucleate cytoplasmic fragment of a bone marrow megakaryocyte, specialized to play a crucial role in hemostasis. Platelets are rich in myosin and actin cytoskeletal elements which facilitate a dramatic shape change phenomenon upon activation. Shape change occurs as a result of agonist stimulation. Contact with collagen fibers causes platelet activation.