A set of criteria for evaluating the quality of heavy-atom partial solutions in macromolecular crystallography have been developed. These have allowed the conversion of the crystal structure-solution process into an optimization problem and have allowed its automation. This 1999 report from Acta Crystallographica D was cited 20 times in current journal articles indexed in the ISI database during January-February 2001. No other chemistry paper published in the last two years, aside from reviews, collected more citations during that two-month period.
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