The data also suggested that the mechanism is related to caffeine intake and not to other nutrients contained in coffee. The odds were tripled when the apnea-hypo apnea index exceeded 15 events per hour. It was concluded that sleep-disordered breathing could be responsible for a substantial number of cases of hypertension and its sequelae, such as cardiovascular and cerebrovascular morbidity and mortality. All results were adjusted for hypertension risk factors such as body mass index, age, sex, and alcohol and cigarette use. Over 5 million Americans have type 2 diabetes and hypertension.
Uncontrolled hypertension can lead to stroke, heart failure, and kidney failure.
The advisory presented results from several studies showing that efforts to lower high blood pressure in patients with type 2 diabetes produces dramatic results. Dr. Fred Reno is running the toxicology program in anticipation of an IND submission in the not too distant future. The progression of pulmonary hypertension is characterized by increased serine elastase activity and the deposition of tenascin-C, a smooth muscle cell survival factor. Recent studies have suggested that elastase inhibitors can suppress the activity of tenascin-C, resulting in smooth muscle cell apoptosis. To examine if elastase inhibitors could play a therapeutic role in pulmonary hypertension, the oral serine elastase inhibitors, M249314 and ZD0892, were administered to a series of rats beginning 21 days after the induction of pulmonary hypertension with monocrotaline.