Reported metastatic sites include lung, brain, ovary, liver, kidney, lymph nodes and eye. Of the domestic animals, carcinoma of the endometrium is reported more frequently in cattle. The tumors may be single or multiple, nodular masses in the uterine wall. The serosal surface is often umbilicated. Metastasis occurs to regional lymph nodes and the lungs.
Uterine adenocarcinoma is the most commonly encountered spontaneous neoplasm in rabbits.
Metastasis and tumor implantation within the liver and lung are similar to the primary neoplasm, often with a prominent stromal component. Conference participants cited tissue identification as the most challenging aspect of this case. Urinary bladder and prostate were considered by many. When given the animal's gender, conference participants had little trouble with the diagnosis.