Instead, they get their start when a plaque breaks away from the wall. When a plaque ruptures, it often releases certain proteins that make the blood clot. The blood clot can then travel through the blood stream toward the heart or brain. If it's big enough, it may eventually plug up an artery, triggering a heart attack or stroke. In its earliest stages, atherosclerosis is a silent disease.
Some people never have symptoms, even as they approach the brink of a heart attack or stroke.
Most people, however, will notice some warning signs. The symptoms may be subtle or severe, but they should never be taken lightly. Clogged arteries in your lower extremities can cause pain, especially in your calves and your feet. The pain usually strikes during exercise and disappears when you rest. If an artery becomes completely blocked, your foot may become pale, cold, and painful.