Usually a febrile illness. Children important in transmission.
Values are only approximate because category includes large numbers of coxsackie and echo viruses.
Most are mild. Many infections are asymptomatic and most infections not confirmed by virology. Exclusion may be necessary in rare outbreaks of serious infection, eg. Campos G. Aseptic meningitis due to echovirus 4 in Panama City, Republic of Panama. Couch RB, Douglas RG, Lindgren KM, Gerone PJ, Knight V. Airborne transmission of respiratory infection with coxsackievirus A type 21.