We have several projects we are pursuing, related to our major interest in understanding the roles of tumor suppressors and oncogenes in the development and progression of maligant tumors. Function of the breast cancer suppressor gene BRCA1. We have also found that the BRCA1 gene product regulates the response to DNA damage in human breast and prostate cancer cells. Thus, cells harboring a BRCA1 mutation may be resistant to genetic damage and may fail to limit their response to proliferative stimuli such as steroid hormones like estrogen.
Scatter factor protects epithelial and cancer cells against apoptosis.
Recent publications Fan S, Wang JA, Meng Q, Yuan R-Q, Ma YX, Erdos MR, Pestell RG, Yuan F, Auborn KJ, Goldber ID, Rosen EM . BRCA1 inhibits estrogen receptor signaling in transfected cells. Implications for understanding how normal tissues and tumors respond to therapeutic radiation. Modulation of proliferation, damage responses, and expression of regulatory proteins. Fan S, Wang JA, Yuan R-Q, Rockwell S, Andres J, Zlatapolskiy A, Goldberg ID, Rosen EM .