Its active components consist of heparan sulfate, dermatan sulfate and chondroitin sulfate. 1,2 Danaparoid is primarily eliminated via the kidneys. Ancrod represents a distinct anticoagulant that is derived from snake venom. 4 Ancrod acts to reduce fibrinogen levels, thereby decreasing plasma viscosity. As well, ancrod may not be useful in patients who are already hypofibrinogenemic.
Warfarin represents a third distinct anticoagulant.
However, its onset of action is slow, taking up to 5 days for full anticoagulant effect. However, if after 48 hours following cessation of heparin and the initiation of danaparoid the platelets do not increase, the possibility of cross-reactivity should be considered and therapy switched to ancrod. SC q8h or 1250 units SC q12h Table 3. Unlike ancrod, administration of danaparoid does not require routine laboratory test assessment for anticoagulation. Danaparoid in the prevention of thromboembolic complications.