This polymerase is composed of two polyproteins translated from the 5' two-thirds of the. Because the genomic information for the two polyproteins overlap, translational frame-shifting occurs. RNA polymerase helps transcribe a full-length minus sense RNA, which serves as a template for new plus strands and a group of 3' nested set of subgenomic mRNAs. The capped leader RNA dissociates from the template and reassociates with a complementary sequence to start copying the template through to its 5' end Each product is unique because only the unique sequence toward the 5' end is translated. Envelope protein M is directed to the cisternae of the endoplasmic reticulum and the Golgi complex.
Virions bud from the regions.
Virions are transported in vesicles to the plasma membrane for exocytosis. Discontinuous transcription makes the 5' segment of each nested transcript the same. Sullivan E. Hensley L. Yount B. Chen W. Persistent infection promotes cross-species transmissibility of mouse hepatitis virus. Journal of Virology. Receptor homologue scanning functions in the maintenance of MHV-A59 persistence in vitro.