Practice, even before you begin. There is no reason to expect any of us to know how to manage these medications from the get go. Success requires a complex package of information, skill and reorganization of our lives. Like any complex task, there is a learning curve and usually a period of making frequent mistakes. Make a plan.
Some people find a detailed plan works best, with cues to different events in daily life schedules.
Others find just a simple and general one enough. Look into mechanical aids. There are pillboxes, timers, beeper systems, refrigerator notes and a host of other little devices that can help remind a person of the time to take pills, or to stop or start eating in preparation. Some have proposed, and are planning, residential programs for a few weeks at the start of combination therapy for those whose success will depend on making and sustaining some significant changes in their lifestyles and habits. Support groups of people who are all dealing with new combination therapy regimens can help.