Flexible formatting allows sandwich, direct, and competitive assay designs for use in immunoassays, quantitation of nucleic acids, receptor-ligand binding, and measurement of viruses and bacteria. Paramagnetic beads, microns in diameter, act as the solid phase and facilitate rapid assay kinetics.
Voltage is applied and resulting luminescence is measured.
Due to the variety of immune responses elicited by G-CSF, clinical therapies are being pursued aimed at increasing neutrophil levels in patients who have developed granulopenia as a side effect of chemotherapy or immunosuppressive treatment regimens. APP is highly enriched in many tissues, including the brain during development, and many different cell types have been shown to synthesize it. GM-CSF was originally thought to function in proliferation and differentiation of granulocytes and macrophages, but has since been demonstrated to induce these activities in a number of other cell types, including cells of erythroid and megakaryocyte lineages. The different effects of IL-2 have generated interest in the regulation and levels of this lymphokine. Due to the variety of responses by the immune system as a result of the presence of IL-2, therapies designed to augment or suppress production of this lymphokine are either already in the clinic or are actively being pursued in basic research laboratories.