This results in more dopamine in the synapse, and more dopamine receptors are activated. In a closer view, show how this affects the function of the cell. The increased activation of dopamine receptors causes increased production of cAMP inside the post-synaptic cell. This causes many changes inside the cell that lead to abnormal firing patterns. Indicate that with continued use of cocaine, the body relies on this drug to maintain rewarding feelings.
Scientists have the ability to see how cocaine actually affects brain function in people.
The scans show where the cocaine interferes with the brain's use of glucose - or its metabolic activity. The left scan is taken from a normal, awake person. The right scan is taken from a cocaine abuser on cocaine. It shows that the brain cannot use glucose nearly as effectively - show the loss of red compared to the left scan. There are many areas of the brain that have reduced metabolic activity.