The earliest identifiable change in Fox-Fordyce disease is the keratinous obstruction of the upper portion of the apocrine duct. It is followed by the rupture of the intraepidermal portion of the apocrine duct with local microvesiculation and acanthosis. These intraepidermal changes separates Fox-Fordyce disease from asymptomatic apocrine sweat retention. Other histopathologic findings are spongiosis and acanthosis of the epidermis in the region of the duct and mucinous and inflammatory infiltration of the adjacent dermis and secretory tubule of the apocrine gland. Although the disease is usually seen after puberty, there are prepubertal case reports.
Treatment is usually unsatisfactory.
The history, clinical appearance and histological findings confirmed our diagnosis as Fox-Fordyce disease. Excessive exercise in the army may have led to excessive sweating and secondary bacterial infection. The lesions responded well to antibiotic therapy within a week and then the treatment was continued with retinoic acide gel. Dermatology in general medicine. Disorders of sweat glands.