2 An associated laboratory abnormality seen in most patients is paraproteinemia. The paraproteinemia most commonly seen is a monoclonal lgG gammopathy, almost always attributable to light chains. The monoclonal gammopathy is benign, and the level of abnormal globulin does not correlate with the extent or prognosis of the disease. Spontaneous regression has been described, yet the disease most often runs a chronic progressive course. Treatment of lichen myxedematosus is often difficult.
Topical therapy is unsatisfactory.
Lichen myxoedematosus with rapid spontaneous regression. Br J Dermatol. J Invest Dermatol. The dermal mucinoses. Br J Dermatol.