A disorder of unknown cause in which insoluble protein fibers become deposited in tissues and organs impairing their function. It is found in association with chronic infection or chronic inflammatory disease. The exact mechanism that causes secondary systemic amyloid is unknown. The risk factors are the presence of chronic inflammatory or infectious diseases.
Symptoms are the same as in primary amyloidosis .
The symptoms are related to the organs that become affected with the deposits. The affected organs exhibit reduced function. The incidence is less than 1 our of 10,000 people. It is very rare in children. The physical examination or abdominal ultrasound shows an enlarged liver or spleen.