H. pylori infection leads to approximately 80 percent of peptic ulcers in the United States. Regular use of these medications, including aspirin, ibuprofen, naproxen and ketoprofen, inhibits production of an enzyme that produces prostaglandins. These substances protect your stomach lining from chemical and physical injury. Without prostaglandins, stomach acids can erode the lining, causing bleeding and ulceration. This potent chemical in tobacco increases the volume and concentration of stomach acids, doubling your risk of an ulcer.
Smoking also slows healing during ulcer treatment.
Excessive use of alcohol can irritate and erode the mucous lining in your stomach and intestines, causing inflammation and bleeding. It's unclear, however, if alcohol alone leads to an ulcer, or if other factors, such as H. pylori, are involved. If you have symptoms that suggest an ulcer, see your health care provider for evaluation and treatment. An ulcer is a condition that is best managed with your doctor. It's OK to take an H-2 blocker for up to 10 days.