This schedule has not been associated with major dermatologic toxicity. Physicians who use hydroxyurea to treat diseases should consider this intermittent administration schedule. B.J. Kennedy, MD University of Minnesota Minneapolis, MN 55455 References 1. Hydroxyurea-induced leg ulceration in 14 patients. Ann Intern Med.
Skin changes secondary to hydroxyurea therapy.
The evolution of hydroxyurea therapy in chronic myelogenous leukemia. Their conclusion that cessation of hydroxyurea therapy is necessary to achieve healing is nevertheless questionable. Because hydroxyurea is used to treat serious underlying systemic disorders, this approach is often impractical, as illustrated by a patient we recently treated at our wound care center. The potential association with hydroxyurea therapy was recognized, and we considered discontinuing this therapy or decreasing the dose. The opinion of the treating hematologist was not to change the dose, however, because the hemoglobin level was still high.