Prepare for interviews by thinking about anecdotes that show how you perform under pressure, how you deal with difficult situations and what skills you've picked up in the past two years. Try having a mock interview with a friend or trusted colleague. If possible, ask an interviewer who rejected you how you could improve your chances for the future. If your interviews seem to go well, check your references. If you notice tension when checking with one of your references, it might mean that person isn't helping you all that much.
Some former bosses give wonderful references, but others can be awfully lukewarm.
By all means, set tough goals for yourself, but realize that some top employers demand a lot of experience before they'll hire anyone. We all want to be millionaires overnight, but sometimes it can actually take a week or two. If you're in a dying industry or tight market, you might get turned down many times before landing a job. Make sure your past failures don't lead to future ones. If you walk in looking like a loser, that's just how you'll walk out.