The Monito gecko's diet and foraging behavior is unknown. No data are available on home range or whether the species establishes a territory. This species is non-migratory and restricted in range to Monito Island. Whether lizards prefer these sites, or have a specific habitat association, is unknown. A complete assessment of specific environmental requirements of the species has not been performed.
Some information is available from data collected during surveys.
All refugia examined were in areas of little or no cover. Information on parental care is unavailable for this species. This behavior has never been documented for any Puerto Rican Sphaerodactylus. There appears to be a predator-prey relationship between geckos and rats. More data on this relationship is needed.