That generally means more snow and ice for the Midwest and Northeast, and colder conditions in the South. Staying safe is as simple as being prepared and knowing how to react.
Tires are important.
Make sure they have adequate tread. All-weather radials are sufficient for most winter conditions. Maintain at least a half tank of gas during the winter season. Pay attention to the latest road conditions by listening to the radio, watching TV, or using the Internet. Travel by daylight and take at least one other person, if possible.