You should space the tobacco plants about 2 ft. Always transplant outside in late evening or when it is cloudy and overcast. Water plants thoroughly after transplanting and water daily each day until plants have become established. When growing in tubs, limit the number of plants grown. Tobacco plants need to be exposed to full sun while growing.
Tobacco roots grow quickly and often close to the surface.
Be careful around plants when hoeing or cultivating around them. Try not to disturb the soil anymore than necessary. As the plant begins growing, remove all suckers as they will sap the plants growth. Tobacco plants suffer from several diseases and are attacked by several leaf chewers. I recommend using sevin dust to control insects.