At this stage, little venom is injected and the bite is not noticed by the patient or reported to a doctor. Second category is characterized by a local cytotoxic reaction. Mild to severe pain usually develops 2-8 hours after the initial bite. Within 3-4 days necrosis develops and a dark eschar develops which gradually hardens. By the 7-14 day the wound edges become uneven and the center of the wound sinks and the eschar sloughs, leaving a painful ulcer.
Third category consists of systemic loxoscelism.
This may occur as early as 24-72 hours after the bite. Children are especially vulnerable. Symptoms are directly proportional to the amount of envenomation. The most common cause of death is massive hemolysis. The diagnosis of a BR spider is often difficult and delayed.