Nothing in, then it is empty. Empty cannot make anything. Because Space dont have form, what we can understand. It is so huge, and this huge is in something. And because we cannot sense it, because our senses are material thing, we cannot say, what kind is it.
Science can only be basic at material space, which dont have form, size, born-time.
Believe or not. We can only speak and do that what we can see. Human race want to study space, travell there. It is only equipment. That is humanity issue.