Such supplementation can cause hyperkalaemia. Spironolactone may enhance the effects of other antihypertensive agents the dose of which may need to be reduced. It should be given with caution with other potassium sparing drugs. Serum electrolytes should be estimated periodically. The symptoms of overdosage are hyperkalaemia clinically characterised by paralysis, or muscle spasm.
Treatment is symptomatic with emphasis on potassium excretion.
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