Reserpine, from species of the genus Rauvolfia , has potent hypotensive activity. The alkaloid produces sedation and tranquilization. It also is a stimulator of prolactin release and may be carcinogenic. Strychnine, a class 1 indole alkaloid, has a portion based on malonyl CoA linked to the molecule. It is well known to be toxic and has been employed as a rotenticide.
Strychnine excites the nervous system and binds to the glycine receptor.
It is not in present medical use. The compound is best known from Strychnos nux-vomica of the Loganiaceae. The dimethoxy-derivative brucine is even more toxic. Class 3 monoterpene-derived alkaloids Vincamine, a Class 3 indole alkaloid, in only found in the Apocynaceae, mostly in Vinca minor. It is used to treat headaches and vertigo.