Protect your e-mail address. Devoted spam-despisers provide tips on constructing filters that automatically remove spam from your inbox. See Engst, MacWeek xxxx. It doesn't do any good to ask to be taken off the mailing list. Your reply merely indicates that you exist, and is an open invitation for more spam.
Some companies exist merely to sell e-mail addresses to spammers.
Usually this does no good, but certain ISP s will act on preventing their subscribers from sending spam. Chase the spammer. OK, this is difficult and ineffective, but potentially satisfying. There ARE ways of tracking them down. Articles in electronic journals can be in color, and include pictures, graphs, and lots of accessory data.