A course of treatment lasts 6 months. Nafarelin, available as a nasal spray called Synarel, relieves symptoms and helps shrink endometrial lesions. Six months after treatment, however, symptoms reappeared in half of those who had been helped. Possible side effects are similar to some of the discomforts of menopause, including hot flashes, vaginal dryness, and lighter, less frequent, or no menstruation. Other effects include headaches and nasal irritation.
Treatment consists of one injection a month for six months.
In clinical studies, the effectiveness of leuprolide has been found to be about the same as that of danazol, according to the manufacturer. Potential side effects are similar to those caused by nafarelin. These drugs, called nonsteroidal anti-inflammatories include Naprosyn, Feldene, Ponstel, Rufen, Clinoril, Motrin, Nalfon, Dolobid, Meclomen, Tolectin, and Indocin. Narcotic pain-killers such as codeine, oxycodone, meperidine and morphine, as well as narcotics combined with other pain relief drugs, may also be prescribed. GNRH agonists Hot flashes, vaginal dryness, calcium loss from bone, mood swings All medications that change your hormonal balance need to be monitored closely by both you and your doctor.