It is hoped that with this more broadly based information, scientists will be able to make important connections. Having made the connections, perhaps greater strides can be made in understanding and protecting our environment, and at the same time, improving human health. This annual review issue has 16 articles. Two articles deal with the field of endocrine disruption. Environmental signaling is reviewed by Cheek et al., whereas Crisp et al. present the U.S. EPA assessment and analysis of endocrine disruption.
Several articles discuss the urgency of developing a rapid method to identify carcinogens.
The use of transgenic animals to address this need is discussed in three papers. Yamamoto et al. introduces the ras H2 mouse as a rapid carcinogenicity testing system. Approaching the issue from a regulatory standpoint, Contrera and DeGeorge discuss the use of transgenics in bioassays of pharmaceuticals. The potential role of transgenics in the U.S. National Toxicology Program is presented by Eastin. Three articles explore models of diseases.