Good therapeutic effect was obtained in 40 cases. A combination of antimicrobial and tissue healing properties is probably responsible for the observed effects. Marigold's essential oil has strong bacteriostatic activity, inhibiting the growth of numerous strains in a nutrient broth, including Staphylococcus aureus, Sarcina citrea, S. Rosa, S. beige, Bacillus subtilis, B. anthracis., and Salmonella enteritdiis. In a final extract concentration of 1 to 2 mg crude drug per 1 cubic centimetre, marigold significantly raised the tonus of the uterine preparation. In fact, among the plants so tested, marigold ranked second only to chamomile in this regard.
Whole marigold possesses spermicidal activity in vitro against rat sperm.
Marigold leaf extract exhibits such activity against human sperm. It should be noted that anti-inflammatory activity of marigold can be seriously inhibited by phenobarbital and certain other sedatives and hypnotics, such as chloral hydrate and meprobamate. This is also true of beta-adrenergic blocking agents, such as propanolol. Marigold - Safety Factors and Toxicity Marigold has exhibited no toxic properties, but there is a chance sensitive people may be allergic to it. It is not intended to replace the advice or attention of health care professionals.