In 1990 the New England Journal of Medicine urged further study on the condition, but no research is being done at present. Many patients demand treatment despite the lack of research because it is empirically effective, and other, more conventional approaches failed. Other practitioners have tried these measures and reported the same positive results. This is recognized as a side-effect of antibiotic use, which patients often link to the onset of their symptoms. The severity of symptoms and their response to treatment is variable.
Some patients report a complete recovery.
Those who have been sick longer may report improvement, but remain unwell. A history of repeatedly or extended exposure to antibiotics prior to developing symptoms supports the diagnosis. I therefore cannot cite an effective treatment. I will summarize what practitioners have reported as effective in the various books on the subject. Doctors who recognize CRC vary in how they treat it, based on their own experience.