2 main groups, cutaneous and mucosal, a substantial number infect the anogenital tract and may cause penile, vulval, and anal warts and penile vulval and cervical cancer. Transmission of these papilloma viruses is sexual and the diseases are sexually transmitted. These infections are very rare in virgins. Infection is directly correlated with the number of partners a couple has had unprotected sex with. The oral mucosa similarly sensitive to these genital viruses.
Several viruses are exclusively infect the oral mucosa.
E7 is a cytoplasmic serine phosphoprotein, and has been shown to be a transcriptional transactivator and transforming protein. E7 binds Rb protein-presumably moves to nucleus. E6 binds to a cellular protein called E6-Ap. This complex then binds to p53. E6-Ap is a ubiquitin ligase.