Not a particularly swift animal, skunks don't need good distance vision to locate prey species which have little or no mobility. The ability to see a predator at a distance is not necessary either, as the threat of spraying its musk will usually deter all but ignorant predators, who soon receive a lesson. Skunks usually give ample warning before they spray their musk. Spraying is a defense mechanism and used only when the animal feels that it is necessary to protect its own life. Warnings usually include a lifting of the tail, a turning of the back towards the danger, and sometimes, a pounding of the front feet in a drummer-like fashion.
Spotted skunks are more agile than striped skunks.
Their territory sizes are similar to striped skunks. This species can climb very well, and they descend trees head first. When threatened, spotted skunks commonly do handstands, balancing on their front feet while they lift their bodies into the air. This balancing act usually lasts for about 5 seconds at a time. The species can spray an offender from this position.