Evidence of severe cardiac disease or fluid overload. Renal impairment, consider lower dose. Suspected delivery within next 2 hours. Circulatory depression or collapse. To facilitate delivery and maintain more constant flow rate medication may be mixed to produce an IV infusion.
Toxicity usually occurs after long term use and high maintenance doses.
Calcium Chloride may be used as antidote if respiratory depression or heart block should develop. If delivery follows Magnesium Sulfate administration within 24 hours, anticipate newborn to show signs of toxicity.