The course emphasizes the molecular control of vertebrate embryogenesis. Advanced treatment of the principles and methods of the molecular biology of eukaryotes, emphasizing the organization, expression, and evolution of eukaryotic genes. Topics include reassociation and hybridization kinetics, gene numbers, genomic organization at the DNA level, mechanisms of recombination, transposable elements, DNA rearrangements, gene amplification, oncogenes, recombinant DNA techniques, transcription and RNA splicing. Students participate in discussions of problems sets on the current literature. A survey of laboratory methods used in research.
Students rotate through the major laboratories of the department.
Required for first year Genetics and Development students. This course is designed to illustrate how genetic systems have played a fundamental role in our understanding of basic biological problems. Continuation of Genetics G6210x. Basic principles and current areas of interest in mouse and human genetics. One hour lecture once a week, followed by student presentations and discussion of papers from the literature.