You can't calibrate a joystick if it isn't plugged in. Finally, you can adjust the sensitivity of your mouse and joystick. The defaults are listed in Command Options. Just click on the action, then type the key you want assigned to it. It's as easy as that.
Some setups work better for some people.
The defaults are set to provide a good frame rate and optimum settings. More RAM and a faster CPU will help you move these options up without a noticeable decrease in responsiveness. This is where you can choose hardware acceleration if you have the required hardware. Moving options down is preferable to moving them up. The settings on this page are preset according to your system's available memory.