Two or more blisters may join to form a large one. The blisters usually burst leaving a raw surface. These heal over a few days. In cattle, the earliest signs are dullness, poor appetite, fever. Salivation and lameness may be seen.
Vesicles appear inside the mouth on the tongue, cheeks and gums, lips and palate.
Vesicle may form between the claws of the feet and along the coronary band. Mortality in adults is usually very low. In pigs, the main sign is lameness. There is also fever and loss of appetite. Vesicles form along the top of the foot, on the heels and between the claws.