Abortion is common. Mortality in piglets can be high. In sheep and goats, the disease is usually milder with fewer lesions. Affected sheep are depressed and reluctant to stand. Some animals may get a sudden lameness.
Vesicles form around the top of the foot and between the claws.
Lesions may develop on the tongue and dental pad, but can be hard to detect. Significant mortality can occur in lambs. In addition to the lesions described above, vesicles may also be present in the rumen. For example from live animals collect vesicular fluid, vesicular fluid epithelium, oesophageal-pharyngeal fluid and whole blood. From dead animals tissue specimens should be taken lymph nodes, thyroid, adrenal, kidney, spleen and heart.