E. A second major focus is studying the role of specific lipoproteins in atherogenesis in animal models and humans.
Several areas are under investigation.
ApoE is a polymorphic protein arising from three alleles at a single gene locus. The three major isoforms, apoE4, apoE3, and apoE2, differ from one another only by single amino acid substitutions, but these changes have profound functional consequences at both the cellular and molecular levels. Role of ApoE in Lipoprotein Metabolism and Type III HLP Type III HLP is a genetic disorder of lipid metabolism characterized by the accumulation of remnant lipoproteins in the plasma and the development of premature atherosclerosis. Yadong Huang and Zhong-Sheng Ji coordinate this component of the research program. Type III HLP can be transmitted as either a recessive or a dominant trait.