See drug interactions. Pernicious anemia, anticonvulsants, anemic. Oral contraceptives, alcohol, cholestyramine, barbiturates, diphenylhydantoin, sulfasalazine, and ant-acids can interfere with the absorption of folic acid. Folic acid may reduced plasma-phenytoin concentration levels. Chloramphenicol can produce a folic acid deficiency.
Tobacco decreases the absorption of folic acid.
Chronic alcohol consumption can produce a folic acid deficiency. Daly L.E., Kirke P.N., Molloy A., et al. Folate levels and neural tube defects. Shaw G.M., O'Malley C.D., Wasserman C.R., et al. Maternal periconceptional use of multivitamins and reduced risk for conotruncal heart defects and limb deficiencies among offspring.