Hematopathology Hematopathology Hemoglobin C Disease Homozygous hemoglobin C disease is a mild hemolytic anemia with splenomegaly. It often is asymptomatic but may cause abdominal discomfort due to splenic enlargement and jaundice due to increased red cell destruction. Red cells are normocytic to microcytic.
Target cells are common.
Sometimes, especially after splenectomy, hexagonal to rod shaped crystals may be seen in red cells. There is a mild increase in reticulocytosis.