Doing so will also call your attention to interesting points, warnings and troubleshooting hints. Flag those by putting a sticky note on the top or side edge of the page with a brief description of what is on the page. The notes may provide a quick way of finding what you need the next time you have to consult the manual. Uninstall, never delete. If your computer came with programs you won't use, uninstall them.
Some programs come with their own uninstall utilities.
If the program does not have an uninstall option, use the Windows Remove utility. These programs are often far more thorough than Windows Remove. And never just delete a program. Just zapping it could cause difficulties later on. Respect the shut-down process.