Use lowest effective dose for shortest period possible. Tinnitus may be a difficult and unreliable indication of toxicity due to age-related hearing loss or eighth cranial nerve damage. CNS adverse effects may be observed in the elderly at lower doses than younger adults . Symptoms of overdose include tinnitus, vomiting, acute renal failure, hyperthermia, irritability, seizures, coma, and metabolic acidosis. For acute ingestion, determine serum salicylate levels 6 hours after ingestion.
Treatment is based upon symptomatology.
Hypersensitivity to salicylates or any component or other nonacetylated salicylates. Treatment can also be based upon symptomatology. Used in the treatment of hypercalcemia, as immunosuppressive agents including use in organ transplantation. Management of respiratorydiseases including asthma, neoplastic diseases, and allergic disorders. Selected agents have been used in postherpetic neuralgia, meningitis, alcoholic hepatitis, and adult respiratory distress syndrome.