New world tarantulas can cause a skin rash to develop if handled either frequently or improperly. The rash is due to the urticating hairs on the spider's abdomen. The hairs are frequently raked off by the hind legs of the spider as a defense mechanism against predators in the wild. Handling is also risky for the spider because a drop from even a relatively low height may rupture the fragile abdomen and means almost certain death for the spider. Unless it is absolutely necessary, tarantulas should not be handled.
Tarantulas are fairly undemanding creatures to keep, provided that their basic requirements are met.
A good suggestion in their captive husbandry is to find out the tarantula's native region and try to duplicate the environment found there. In effect, this will give almost all of the information required to maintain it and to have it flourish in captivity. When all preconceived notions are put aside, tarantulas can make fascinating display animals.