Case reports also exist of SCC of the thymus and vulva and of poorly differentiated SCC of the cervical lymph nodes with an unknown primary tumor. Rare associated cancers reported include anaplastic small cell carcinoma of the lung and adenocarcinoma of the uterus. Physical examination may indicate the need for specific laboratory studies in the search for underlying malignancy. Other screening laboratory studies may reveal evidence of GI or renal malignancies. Some authors have noted vacuolar degeneration of the basal cell layer with occasional bullae formation.
Treatment depends on the type and stage of the underlying neoplasm.
Often, treating the neoplasm improves the cutaneous disease. If the neoplasm is cured, skin signs abate. While specific treatment of the skin improves the eruption, this usually is not curative. Topical corticosteroids may improve scaly lesions. Therapy with cholecalciferol also has been reported to be of benefit.