In fact, menstrual bleeding under 2 years of age has been the first symptom of McCune-Albright syndrome in 85 percent of patients. Although ovarian cysts and irregular menstrual bleeding may continue into adolescence and adulthood, many adult women with McCune-Albright syndrome are fertile, and can bear normal children. The precocious puberty in McCune-Albright syndrome has been difficult to treat. After surgical removal of the cyst or of the entire affected ovary, cysts usually recur in the remaining ovary. A progesterone-like hormone called Provera can be given to suppress the menstrual bleeding, but does not appear to slow the rapid rates of growth and bone development, and may have unwanted effects on adrenal functioning.
Some patients have subtle structural changes detected only by ultrasonography.
Growth Hormone Excessive secretion of pituitary growth hormone has been seen in a few patients with McCune-Albright syndrome. Therapy has included surgical removal of the area of the pituitary which is secreting the hormone, and use of new, synthetic analogs of the hormone somatostatin, which suppress growth hormone secretion. Although rare, adrenal enlargement and excessive secretion of the adrenal hormone cortisol is seen in McCune-Albright syndrome. This may cause obesity of the face and trunk, weight gain, skin fragility and cessation of growth in childhood. Treatment is removal of the affected adrenal glands, or use of drugs which block cortisol synthesis.