The City of Gainesville is laid out in quadrants. Avenues run East-West.
Streets run North-South.
Zeroth avenue, aka University Avenue, divides the city into North and South. Zeroth street, aka Main Street, divides the city into East and West. There are multiple access points to the UF campus. At airport ask for directions to I-75 northbound. The Florida Turnpike will eventually merge with I-75 northbound.