For biopsy findings, see Histologic Findings. Lesions of bullosis diabeticorum have a heterogeneous histologic presentation. The blister plane may appear in a subcorneal, intraepidermal, or subepidermal location. The variable blister plane likely is related to the blister age, as reepithelialization can occur within days of blister onset. Anchoring fibrils and hemidesmosomes are reported absent or decreased in early blisters.
Specific treatment is unnecessary since the condition is self-limiting.
Lesions often recur and secondary infection may develop, but the prognosis typically is good. Unroofed blister on the leg. Note the irregular shape. A case report and literature review. Idiopathic bullae in diabetics.