Depo-Provera suppresses or lessens the frequency of erection and ejaculation and also lessens the feeling of libido and the mental imagery of sexual arousal. Antiandrogenic Effect of Depo-Provera. Antiandrogen inhibits the release of androgen, the so-called male hormone, from the testicles.
Some progestinic hormone is normally present in the male body, but at a very low level.
Increasing the level allows progestin to compete with androgen and to take over. Androgen is a sexual activator. Progestin in the male is sexually inert. It therefore induces a period of sexual quiescence in which the sex drive is at rest. Mode of Endocrine Action.