Barb, Mike, Lisa and Paola in the lab. Barb and Lisa with pharmacological probes. Jun playing with his food, while Sam, Mohamad and Lisa pretend not to notice. Bodyguards Kapatos and Kuhn keep a close eye on Chris Whitty, who offers his first-born to the 'Godfather' .
Special emphasis is placed on the dysfunction of neurotransmission in neuropsychiatric disorders.
The laboratory provides an active, highly collaborative teaching environment in which animal models, cell culture models and human postmortem material, and a combination of neurochemical, anatomical and molecular biological approaches are employed. We have cloned the promoter region of the DATgene, and are determining the transcription factors that enhance and silence its expression. In parallel, changes in gene expression of DAT and its regulators is being assessed in human postmortem brain from drug abusers. These newly discovered proteins may play a key role in desensitization, such as occurs after repeated drug exposure. We and our colleagues Drs.