Affected children have difficulty controlling fevers and mild illness may produce extremely high fevers, because of absent temperature regulation by sweating . Affected adults are unable to tolerate a warm environment and require special measures to maintain a normal body temperature . Mucus membrane involvement results in chronic nasal infections with foul-smelling discharge and increased respiratory infections. Hair may be absent or very scanty. The skin is thin with light pigmentation.
Teeth develop abnormally and many teeth are missing.
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