However most dogs will tolerate it after the first 48 hours. Estolate may be used instead of stearate. Estolate may be given with food that reduces the incidence of vomiting while stearate should be given on an empty stomach. Start with a lower dose and then increase to the full dose in 2-3 days. It is more expensive than erythromycin but easier to dose for small dogs.
Vomiting is less common than with erythromycin.
It should be given on an empty stomach. Cross-resistance with erythromycin is common. Cross-resistance with lincomycin is common. It is indicated for deep infections especially in patients with infections in deep fibrotic tissues. Resistance develops rapidly and bone marrow suppression has been reported as a possible side effect.