It becomes like a snowball going downhill. One doesn t necessarily care what the little pea was that caused all this shit. And below the waterline the ship is full of holes and they re sinking. You keep plugging holes, but they re still sinking. If I disregulate your immune system, and that disregulates your brain and injures it, and the injured brain now makes hormones that become toxic to you, which further injure you so that your natural killer cells drop and allow the reactivation of viruses you caught in childhood, which further injure you we now have about seven holes below the waterline.
Systems break down, problems beget problems.
After a while, what is wrong with you is more important than what started the avalanche. But we need a new way of thinking. This disease is made up of complex networks of interacting systems. But we may never find the bug. And even if we find it we may never be able to do anything with it.