May see a residual calcified lung nodule, and a positive histoplasmin skin test. Multiple small parenchymal granulomas . Solitary large histoplasmoma . Meningitis , characterized by fibroblastic proliferation, and hydrocephalus . Diagnosis made by a variety of techniques.
Skin test is usually positive.
Chest XRay shows a Ghon focus . CSF reveals a m ild pleocytosis , elevated protein, low glucose. Fungus may be seen if the sediment is spun and stained with Giemsa or Wright's stain . Surgical resection of isolated intraparenchymal histoplasmomas . Amphotericin B .