Don't forget to note the similarities here with the fourth trumpet. This again shows God using nature to bring about repentance. However, these ungodly people are not going to repent, even under God's harshest judgments. Some men repent and turn to God under hardships, others bow their necks and rebel all the more. Back in Egypt God's message hardened Pharaoh's heart.
Some sinners are beyond repentance.
The fifth bowl of wrath is upon the Beast himself. Here is the complete collapse of Rome under the heavy weight of her own moral decadence. The sixth bowl of wrath is upon the Great River Euphrates, which symbolizes the complete destruction of Rome by invading armies. This symbols of this chapter are connoting the fact that Rome will not give up without a fight. They deceived the kings of all the earth.