The blisters usually burst leaving a raw surface. These heal over a few days. In dairy cattle, a sudden drop in milk yield. In cattle, the earliest signs are dullness, poor appetite, fever. Salivation and lameness may be seen.
Vesicles appear inside the mouth on the tongue, cheeks and gums, lips and palate.
Vesicles may form between the claws of the feet and along the coronary band. They may also appear on the teats and udder - reduced lactation, mastitis and abortion are common. Mortality in adults is usually very low. In pigs, the main sign is lameness. There is also fever and loss of appetite.