Because of other CNS effects, such as dizziness, lightheadedness, nervousness, fatigue, and headache, caution should be exercised in the undertaking of tasks requiring mental alertness until the effects of the drug are known. Some CNS side effects occur during the first few weeks of therapy, and tolerance can develop after 1 or 2 weeks. Muscle tremor and musculoskeletal aches and pains have been reported during therapy with trazodone, which may due to weak skeletal muscle-relaxant activity. Blurred vision during therapy with trazodone may be an anticholinergic effect. Patients experiencing ocular changes should have an ophthalmological examination.
Trazodone is chemically different from other antidepressants.
It can help patients whose depression has not responded to other medications, or who have experienced limiting side effects with other antidepressants. Generic trazodone tablets are not yet available. Take trazodone tablets by mouth. Follow the directions on the prescription label. Swallow the tablets with a drink of water.