Tendon and muscle rupture can also occur. At birth, clubfeet are common. Premature aging of the skin of the hands and feet, called acrogeria, is also a common sign. Other symptoms may occur such as varicose veins, arteriovenousfistula, pneumothorax and pneumohemothorax, carotid-cavernousfistula, and wound dehiscence, especially during and after surgery. In the phenotype, the most severe, frequently results in the loss of the ability to walk in the 20's and 30's.
Scleral weakness can lead to the rupture of the ocular globe after a minor injury.
Diminished amount of bone tissue, abnormally small cornea, and Marfan like features may also be present. Kyphoscoliosis Radio logically mild osteopenia 6. The ability for wounds to heal is not impaired and scars are not atrophic. Umbilical and inguinal hernias can also occur. There is a small amount of people with this type of Ehlers-Danlos Syndrome.