Irreversible binding implies that, until we make new enzymes, we will have excess acetylcholine. But beware of spreading the contamination. May need to maintain for long periods of time. Similar symptoms, but fewer CNS sequelae and shorter duration.
Treatment is similar regarding decontamination, use of atropine, but pralidoxime is contraindicated.
Symptoms of the purified muscarine are those of cholinergic poisoning, especially of course at muscarinic receptors. These are not my exam questions about cholinergics. . . The selective use of organophosphate and carbamate compounds depends primarily upon the pharmacokinetic differences between humans and insects. Pharmacokinetic differences are also important in the toxicity of pyrethrum and its analogues. Pyrethrum - massive CNS excitation, increase in sodium influx poorly absorbed, rapidly metabolized in humans.