Avoid sitting with your legs crossed. Make sure your doctor checks your feet at each visit. If you are unable to care for your feet, ask to be referred to a podiatrist. Several drugs are under study, but not ready for humans yet. One is myoinostol, which is thought to be missing in the nerves of diabetic animals and humans.
Supplements increase the levels in research animals.
Another is the drug aminoguanidine which in animals blocks cross-linking of proteins that occur more frequently than normal in tissues exposed to high levels of glucose. ARI's are a class of drugs that are thought to block the formation of the sugar alcohol sorbitol which is thought to damage nerves. So far clinical trials have shown that these drugs cause major side effects so they are not available for clinical use. Recent research shows that antidepressants and anticonvulsants have similar efficacy in neuropathic pain, although side effects were more of a problem with the former. The article is in the December Journal of Pain and Symptom Management, by Dr. Henry McQuay.