Valsartan is rapidly absorbed with maximum blood levels occurring one to two hours after taking the drug. Half-life is about 8 hours and most of the drug is excreted in the stool. Dose should not be more than 80 mg daily in patients with weak liver function. Valsartan should not be used in patients with severe liver dysfunction. No important drug interactions have been seen yet.
Valsartan reduces blood pressure.
Starting dose is 80 mg once daily. If required, the dose may either be increased to 160 mg once daily or hydrochlorothiazide may be added. Valsartan in Heart Failure Trial. Quality of life is best measured in trials by questionnaire. Disease progression is measured by measuring mortality and hospitalizations.