Move the mouse. Most new systems ship with a PS2 mouse installed using IRQ12. This tip may not work in your machine. BIOS will still reserve IRQ 12 for a PS2 mouse. Take control of your sound card.
Some systems come with a sound card that is on multiple IRQs.
This can be very frustrating, but I have found a fix for this that works on most systems. This is usually the primary resourses of the card. I have discovered that you can go into device manager and disable the secondary IRQ and still have a fully functional sound card. Here is what you do. Go back into device manager and check out the IRQ listing.