Once injected, the material elicits a low-grade inflammatory reaction. The carrier is removed by the body and excreted by the kidneys. Collagen encapsulates and localizes the silicone, and animal studies have shown no evidence of foreign body migration. Therefore, overcorrection is not advised. Case series have reported no major complications with Bioplastique other than overcorrection.
Subcutaneous placement is recommended to avoid palpable nodularity.
Arteplast Arteplast was introduced in Europe in 1991. Gelatin is resorbed and replaced by native collagen. A rat model has shown that collagen deposition is detected at 3 weeks, and the density of collagen increases thereafter. The decrease in space between microspheres is believed to be the result of collagen deposition and consolidation, leading to loss of volume correction. PMMA beads average 20-40 m m in size and theoretically are subject to phagocytosis.