They're filling out the details of why the cell divides even without an androgen molecule. And they're looking for drugs to repair these mistakes. CapCURE's researchers are working on several pathways that bypass hormone control. It is located at chromosome 17q21. In some prostate cancers, the gene is also overproduced, but the DNA is not repeated, and reports on its significance have been conflicting.
Tyrosine kinases are a class of enzymes that are implicated in a range of cancers.
Biochemically they phosphorylate certain proteins at the tyrosine. It's a major mechanism by which the proteins in these cascades are turned on and off. The phosphatases work in the other direction. They take the phosphate off tyrosine. So the kinase is the on switch, the phosphatase is the off switch.