Heavy chain of 215 kD. Head region like other myosins. Protein from chick brain forms dimers but not filaments. I that bind calmodulin. Similar to a yeast gene, MYO2 . Mild alleles have light coat color because melanocytes do not have proper dendrites to deliver pigment granules into hair shafts.
Severe alleles have nervous system defects suggestive of neuron malfunction.
Null mutation is lethal. Ts mutation on shift to restrictive temperature shows no growth of bud. Protein at tip of bud. Mutant accumulates abnormal vesicles - identity unknown, not an obvious backup at one position along the secretory pathway. The second member of the myosin-V family in yeast.