Read the Hotel section for the best of the hotel choices. Taxis are easy to come by. Parking is becoming next to impossible on weekends. If you are driving, valet park your car at some central restaurant or hotel like the Delano, if the town parking lots are full, and take taxis to get around. October and November especially.
Thanksgiving is quite popular with the elite homosexual crowd.
Weekdays are more sane than weekends. Drugs are a big part of the club culture. Coke, ecstasy, heroin, pot, whatever. Keep it in mind if you plan on picking someone up. That warm and fuzzy vibe you are picking up from some model wannabe may be more a product of the ecstasy than how much he or she really digs you.