In each case, we found a peak at the expected size of the protein molecule. In many cases, we also found peaks at smaller sizes which could be identified with known subunits of the proteins, and in some cases we found aggregates corresponding to two or more monomers. This work establishes a new method of size analysis of large molecules, having a very large molecular weight range along with advantages of sensitivity, speed, and long-term stability over other methods. We have used the same apparatus to analyze other biomolecules such as DNA oligomers, as well as some other nanometer-range entities such aggregates, emulsions and sols. Contact Nick Hill for further information or specific application questions.
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