Without intrinsic factor pernicious anemia will develop. Gastroferrin - binds preventing formation of insoluble iron salts and phosphates. Food reaches the stomach eliciting distension and raises luminal pH. Phase 3. Activation of stretch, osmo- and nutrient receptors 1. Major Mechanisms for Stimulation of Gastric Acid Secretion 2.
Signals originate from duodenum.
There are three primary enteric mechanisms which can act to inhibit gastric secretions. The gastric mucosal barrier is critical for protection against ulceration of the epithelia by HCl. The barrier is dependent on competent surface mucosal cells connected by tight junctions, and covered with mucus trapping an alkaline fluid at the cell surface. Any substances which disrupt these interactions will lead to deleterious effects on the Epithelial Lining. Bile salts and lysolecithin are biological detergents which can solubilize the mucus barrier and cell membranes.