Prostaglandin D2 and E2 are somnogenic and pyrogenic and immuno-suppressive substances in mammals. Our finding challenges the conventional pathology that major malaria symptoms are caused by the host-produced prostaglandins. On the other hand, the parasite may take an advantage by producing prostaglandin E2 to inhibit the TNF production by the host cell that is harmful to the parasite proliferation. Development of anti-malarials by drug design. Using purified DHFR, the inhibitory effects of folate analogues are being assayed in an in vitro enzyme reaction.
Structural information is collected for computer drug design.
Molecular mechanisms underlying the intraerythrocytic proliferation of P. falciparum Malaria is clinically manifested only when the malaria parasite enters the intraerythrocytic cycle in human host. Elucidation of the molecular mechanisms underlying the intraerythrocytic proliferation of the parasite is of great importance to reveal the parasite feature that would be a basis for rational development of new drugs for malaria therapy.