Methylation is a mover and shaker. It makes adrenaline from norepinephrine, and melatonin from serotonin. It is crucial for the transcription of DNA, and other entities. The only methylation reaction that doesn't require SAMe is the conversion of its own by-product back to methionine. Once SAMe is created, important things happen.
Scientists are aware that chemicals create free radicals that cause cancer.
Scientists also know that cancer cells have abnormal methylation. The connection between abnormal methylation and free radicals was put together when researchers at Northwestern University showed that if you oxidize a little section of DNA, it causes abnormal methylation. Free radicals attach themselves to nucleic acids and alter methylation. Methylation is a biochemical process that starts with methionine. When methionine reacts with ATP, SAMe is formed.