We have found that a main reason for the surfactant dysfunction to develop is an inhibition by plasma proteins invading the airways. We conclude that an important reason for symptoms of asthma to develop is the characteristic inflammation causing a surfactant dysfunction. PLA2 originating from macrophages and PLB from eosinophiles. Another study angle will be to investigate if the concentration of the apoprotein SP-A is so low in the asthmatics that it will not fulfill its normal function of counteracting protein inhibition. B.A. Disruption of pulmonary surfactant s ability to maintain openness of a narrow tube.
Surfactant dysfunction develops when the immunized guinea pig is challenged with ovalbumin aerosol.
Ozone affects breathing and pulmonary surfactant function in mice.