Stefan Hohmann lab Stefan Hohmann, Ph.D., Visiting professor.
Yeast cells adapt internal osmolarity by altering their glycerol content.
This signalling cascade appears to respond to changes in osmolarity and to control a number of cellular processes in osmoadaption, including glycerol production. Recent results indicate that osmotic regulation of the expression of GPD1 is a much more complex process than previously anticipated. Most probably different pathways are involved in the rapid induction and repression of the GPD1 mRNA levels during changes in external osmolarity. We have recently identified a channel protein, Fps1, which promotes glycerol diffusion through the membrane. Fps1 is strongly regulated by changes in external osmolarity.