However, with time, the clear spaces become involved with opacity. This later onset opacity in the previously clear spaces is usually much more superficial than the longstanding, dense white granules. The vision declines dramatically when the clear spaces opacify. When a corneal transplant is performed, the specimen is submitted for histopathologic evaluation Masson trichrome stains deposits bright red. Masson trichrome stains deposits bright red.
Some physicians treat recurrent erosions with frequent antibiotic ointments while awake.
Excimer laser PTK is quite effective at removing opacities from the superficial cornea. When deep opacities are causing significant visual symptoms, corneal transplantation may be required. Excimer laser PTK removes superficial opacities, smoothens the corneal surface, and allows the epithelium to re-adhere more tightly. If the visual acuity drops and most of the opacities are deep, lamellar or full-thickness corneal transplantation can be performed. Although the success rate for corneal transplantation is very high, granular deposits recur with time.