However the ensuing chronic infection may cause significant destruction of regional lymph nodes and perigenital tissue. Early and prolonged treatment is required to reduce the chronic phase of infection. Patients with LGV must be screened for other STIs, especially syphilis. LGV may facilitate the transmission of HIV infection. TOP OF PAGE Aetiology and epidemiology Lymphogranuloma venereum is a systemic disease caused by Chlamydia trachomatis , predominantly serotypes L1, L2 and L3.
Transmission is through direct contact with open lesions, usually during sexual activity.
The primary genital lesion starts as a small blister which breaks down to form a is a transient ulcer which is commonly unnoticed. Spread from the primary site to regional nodes cause lymphadenitis and constitutional symptoms. The organism predominantly targets lymphatic tissue rather than skin and mucous membranes. Lymphogranuloma venereum has become rare in developed countries since the 1960s. It occurs worldwide, especially in tropical and subtropical countries.