Nonallergic patients without evidence of neurosyphilis should be treated with the following regimen. Other Management Considerations Patients with symptomatic late syphilis should undergo CSF examination before therapy.
Some experts treat all patients who have cardiovascular syphilis with a neurosyphilis regimen.
The complete management of patients with cardiovascular or gummatous syphilis is beyond the scope of these guidelines. These patients should be managed in consultation with experts. There is minimal evidence regarding follow-up of patients infected with late syphilis. Clinical response depends partly on the nature of the lesions. Management of Sex Partners Refer to General Principles, Management of Sex Partners.