A Shabbos stay in a non-Jewish setting can be physically and spiritually trying. When you are traveling, the ideal is to find an observant Jew to invite you for Shabbos or at least for meals. Jews around the world will be more than happy to have you as a guest when you visit their city. If at all possible, try to locate yourself near a shul, so that you daven with a minyan. Of course, this is the ideal during the week as well.
Some laws concerning prayer are time-sensitive.
When traveling, check the earliest and latest local times for saying Shema and Shemoneh Esreh. Be extremely careful to ascertain the proper time for lighting candles Friday night. And remember to bring Shabbos candles with you. Staying in a hotel for Shabbos raises specific issues. Many hotels have switched from a manual key system to an electronic card system for their room doors.