I have not been able to find anything in the literature about aggravation of depression by antidepressants, and my wife's doctors are perplexed. It is not unusual for people to claim that they are feeling much better after only a few days on a antidepressant, however this is much too quick a time frame to expect any response. Antidepressants have to be taken on a regular basis and only start to work on depressive symptoms after 3-6 weeks of treatment. Side effects, such as sedation, will be experienced quickly and this is usually what people associate with improvement. Serzone and Imipramine have some sedating properties that some people find beneficial against anxiety or insomnia, however that is not a true antidepressant effect.
Sedation usually wears off as the antidepressant effect starts to kick in.
It seems to be too strong right after I take it. My thinking is fuzzy but it does wear off. Taking 1 tablet a day is not enough either. This will not create a large problem for most people but some may find that it is slightly over-stimulating and may increase their anxiety levels. As well, people with a seizure disorder should be very careful because absorbing too much bupropion can be associated with triggering seizures.