Thin, less indurated lesions can be confused with nummular eczema. Squamous cell carcinoma should be considered as the diagnosis if an isolated area of presumed psoriasis or eczematous dermatitis is unresponsive to therapy. Rarely, squamous cell carcinoma of the skin may metastasize to regional lymph nodes and to other organs. The likelihood of metastasis is dependent on both the etiologic factor that predisposed the patient to the development of tumor, and on the anatomic location of the tumor. Diagnosis and Treatment Squamous cell carcinoma is best diagnosed histologically, with a biopsy of the suspected lesion.
Surgical removal is the therapy of choice for squamous cell carcinoma.
Options include excision or Moh's surgery, depending on the characteristics of the tumor and the location.