Key search terms included famotidine, schizophrenia, and histamine.
Schizophrenia is a complicated disorder associated with high morbidity if left unmanaged.
An evaluation of studies focusing on famotidine in the management of schizophrenic symptoms was conducted. Famotidine can improve schizophrenic symptoms that were otherwise refractory to typical antipsychotic agents. Further studies should be conducted to determine if other H 2 -antagonists are also effective.