I'm Dr. Gabe Mirkin on Fitness. The patients had clinical disease with or without diagnostic antibody titers to B, burgdorferi. VP Mursic, W Marget, U Busch, DP Rigler, S Hagl. Kill kinetics of Borrelia burgdorferi and bacterial findings in relation to the treatment of lyme borreliosis. Patients with erythema migrans can fail to respond to antibiotic therapy, Persistent or recurrent erythema migrans, major sequelae such as meningitis and arthritis, survival of Borrelia burgdorferi and significant and persistent increase of antibody titres against B. burgdorferi after antibiotic therapy are strong indications of a treatment failure, Most, if not all, antibiotics used so far have been associated with a treatment failure in patients with erythema migrans, Roxithromycin and erythromycin are definitely or probably ineffective.
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Treatment failure in erythema migrans - A review. Antibiotic treatment is the cornerstone of Lyme arthritis treatment. MA Cimmino, GL Moggiana, M Parisi, S Accardo. Treatment of Lyme arthritis. A ''minority'' opinion about the diagnosis and treatment of Lyme arthritis.