A second major interest is the relationship of the control of human mitochondrial replication by a nuclear gene and the relationship of this gene to the lethal human disease call mitochondrial myopathy. This form of mitochondrial myopathy is autosomal dominant and is manifested as a deletions of mitochondrial DNA from a fixed site from near the putative replication terminus. One of the exciting goals of our laboratory is to clone the myopathy gene, purify the encoded protein and study what role this protein plays in the control of human mitochondrial DNA replication.
Students participate in all aspects of the projects.
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