It is often related to my failed marriage and the feeling that I failed my children. I am not miserable with guilt. Knowing God accepts me helps. But I also see guilt as being similar to physical pain. Guilt, like physical pain, is a warning of possible damage to your body.
Some men wish to destroy their consciences.
This is like the lepers who loose their fingers and toes after their extremities become numb, bumping into things and burning themselves without noticing. Questions in matters of faith can also be uncomfortable. On the one hand, I entertain differences. Whenever I study the Bible, I read commentaries by Liberal and Conservative writers. This stirs up a lot of questions.