Gestation lasts only 28 days, and litters are made up of about three young. Desert cottontails produce only about 5 litters per year. A female builds a nest by digging a hole in the ground, then are lined with a layer of dried grasses, and the inside is filled entirely with rabbit fur. Their eyes open by day 10, and they leave the nest at the age of just under two weeks. They remain near the nest for another three weeks.
Sexual maturity is achieved by the age of three months.
Diet Grass, fruits, nuts, and vegetables when available. The life span is 2 years or less.