Mexican buckeye presumably provides cover for a variety of wildlife species. Trees may also produce shade for domestic livestock. However, in view of its toxicity to rats in laboratory studies, this use should probably be discouraged. However, results of laboratory tests with rats soon put an end to these culinary experiments. Each plant produces an abundance of seed annually.
Some seed falls from the plant when fruit first ripens in the fall.
Seedlings grow well in full sun on warm, damp soil. Those grown in even partial shade may appear stunted and eventually die. Conditions necessary for seedling establishment, such as warm, but moist soil and full sun, may be rare in the desert Southwest. Seedling establishment generally occurs only in years with unusually abundant late summer and early fall rainfall. Mexican buckeye grows in a number of riparian woodland communities.