The exact mechanism that causes secondary systemic amyloid is unknown. The risk factors are the presence of chronic inflammatory or infectious diseases.
Symptoms are the same as in primary amyloidosis .
The symptoms are related to the organs that become affected with the deposits. The affected organs exhibit reduced function. The incidence is less than 1 our of 10,000 people. It is very rare in children. Secondary prevention includes aggressive treatment and control of diseases known to predispose to the development of amyloid .