If it is still visible, or if dry flaking occurs from the gel within a minute or so, you are using too much. Try to keep the medication away from the corners of the nose, mouth, eyes and open wounds. Spread it away from these areas when applying. In the first few weeks, you are likely to see Tretinoin working to dislodge blackheads. During the early days of treatment, there may also be some mild burning, stinging, feeling or warmth or peeling.
Some patients also notice their skin begins to take on a reddish blush.
These reactions will usually disappear within two to four weeks. Do not stop using your medication. By about three to six weeks, some patients notice a sudden appearance of new papules and pustules. That is a sign that your medication is working - not that your acne is getting worse. After about six weeks of therapy, you should notice a continued improvement in your appearance.