There may be a history of inflammatory process involving the skin preceding development of loose folds of skin. Patients may have a family history of skin disorder. There may be a history of prior penicillin or penicillamine use. Skin - Primary lesion Skin is loose, inelastic, and hangs in folds. Loose pendulous skin gives appearance of aging, so patients appear much older than their actual age.
Skin demonstrates decreased elastic recoil on stretching.
Underlying cause of CL is unknown and probably variable. Although there are no routine laboratory findings in CL, CBC may reveal normochromic, normocytic anemia, while total protein and beta-2 microglobulin may be elevated. Additionally, serum protein electrophoresis and quantitative immunoglobulins can be performed to assess for myeloma. Direct immunofluorescence studies for IgG, IgA, IgM, C3, C1q, and fibrin may be performed to assess for related conditions such as lupus erythematosus. ANA levels can be measured.