The space ship is now controlled by a computer which has evolved organically. In addition to this, the human inhabitants cannot have children and are affected by a plague, the Morbus Gravis, which causes them to mutate horribly. Picture this if you will. You're on board a decaying spaceship. In eurocomics she goes out and hustles.
Trouble is it's a nasty and dangerous world out there.
Druuna frequently loses her clothes and has to indulge in all manner of sexual adventures with lovers, bandits, mutants, scientists and the like. Druuna is also a feistier heroine in this story. The plot gets more complex when another space ship arrives. On board is old Serpieri himself . Later Druuna adventures become more sexually explicit but arguably less dramatically interesting - if you care.