When severe enough, cirrhosis leads to ammonia toxicity .
Therapy depends on the cause and severity of the disease.
Limited thoracic expansion due to hepatomegaly or ascites and endocrine changes such as menstrual irregularities, testicular atrophy, gynecomastia, and loss of chest and axillary hair may also be present. Daily weights are obtained, fluid and electrolyte balance is monitored, and abdominal girth is measured. The ankles, sacrum, and scrotum are also assessed for dependent edema. The stools are inspected for color, amount, and consistency. Stools and vomitus are tested for occult blood.