The TOR signaling cascade regulates gene expression in response to nutrients. Protein kinase activity and identification of a toxic effector domain of the target of rapamycin TOR proteins in yeast. TOR kinase homologs function in a signal transduction pathway that is conserved from yeast to mammals.
Signal transduction cascades as targets for therapeutic intervention by natural products.
Mammalian RAFT1 kinase domain provides rapamycin-sensitive TOR function in yeast.