None of these agents has successfully demonstrated convincing evidence of clinical efficacy. Better strategies to inhibit endotoxin effects, modulate nitric oxide synthesis, attenuate coagulopathy, and regulate the immune response to sepsis indicate that improved therapies for sepsis may be available within the next few years. It is hoped that improvements in supportive care, vasopressor and fluid management, and treatment strategies to disrupt the pathophysiology of sepsis will prove beneficial to septic patients in the near future.
Septic shock remains a major challenge in the current management of critically ill patients.
Improving the outcome of this syndrome requires a concerted effort by scientists, clinical investigators, and dedicated clinicians.