Acetonitrile metabolizes into cyanide over 2 to 8 hours, so symptoms or signs of toxicity may be delayed after significant exposures. Consider cyanide antidote as clinically indicated, such as sodium thiosulfate and sodium nitrate. Monitor cyanide levels, arterial blood gases, and acid-base balance. Contact with strong oxidizers may cause fire. Above flash point, vapor-air mixtures are explosive within flammable limits noted above.
Vapors can flow along surfaces to distant ignition source and flash back.
Sealed containers may rupture when heated. Sensitive to static discharge. Dry chemical, foam or carbon dioxide. Water spray may be used to keep fire exposed containers cool. If a leak or spill has not ignited, use water spray to disperse the vapors, to protect personnel attempting to stop leak, and to flush spills away from exposures.