These molecular and genetic studies in mice may reveal potential sites of drug actions on central nociceptive pathways and thus aid in the new pharmacological strategies for pain relief. Chen Z-F, Guenther T, Kim J, et al. Genetic ablation of parathyroid glands by targeted mutation of Glial cells missing2 reveals an auxiliary source of parathyroid hormone secretion. Nature 2000 Forthcoming. Neurogenin1 is essential for the determination of neuronal precursors for proximal cranial sensory ganglia.
Twist is required in head mesenchyme for cranial neural tube morphogenesis.