Moisture in the air will condense and then freeze, which can possibly prevent the flow of gasoline to your engine. Winter weather can cause delays, so you need to account for that. Leave more stopping distance than normal between you and the car in front of you. Snow and ice will make stopping more difficult than on perfect roads. Pay extra attention to your surroundings.
Snowy conditions can make visibility go way down.
Watch carefully for flashing lights indicating slow-moving vehicles ahead of you. Slow down your driving. Just because the speed limit says 65 mph doesn't mean you should drive that fast, especially in winter weather. Snow and ice can change road conditions drastically, and you need to adjust your driving because of that possibility. Travel during daylight hours, if possible.