Antibiotic resistance or resistance development. Non-multiplying bacteria are not sensitive to most antibiotics. L-forms of bacteria. Cell wall deficient bacteria are not susceptible to B-lactam antibiotics. Encapsulated bacteria effect oposinization and phagocytosis.
Some antibiotics are detrimental to phagocytosis.
The host fails to clear infection suppressed by the antibiotic, reinfection occurs from the teat canal, or inch susceptibility to reinfections due to inflammation of the gland. Antibiotic susceptibility testing is questionable and should be used to selectively eliminate drugs to which the organisms is not sensitive, not to select drugs considered likely to be successful. Nat Mast Council meeting, 1986. Craven N. Efficacy and financial value of antibiotic treatment of bovine clinical mastitis during lactation - A review. Economic evaluation of Staphylococcus aureus reduction strategies in 3 herds.