Uniting ourselves with the God-man, Christ Jesus, is the lofty purpose of our lives on earth. We are sharing now in his life, passion and triumph over death, and if so we will come to share in his own divine nature even now in this life but fully in heaven. During our life on earth we are being allowed to share in various ways in Jesus' own life and in his sufferings. Our way to God is then to try to peacefully accept and cooperate with God in our daily lives as God has planned them for us, as he permits them to be. This includes both the good things which are so abundantly present as well as the difficulties which eventually get resolved.
Some burdens seem to be always a part of our lives.
We can accept these and offer them to God with and through Jesus Christ not only for ourselves but for others too, the whole needy world. Jesus gave us his example to follow always, but especially during the difficult times. Difficulties are part of everyone's life, but I think that Jesus has shown us what our basic response should always be. Certainly we must, first of all, do our reasonable best to correct or to alleviate any illness or disability, for instance. But when our best efforts fail, it seems to me that we ought to recognize God's hand in the situation.