PPT Slide Slide 26 of 31 Antiestrogens reduce plasma levels of endothelin-1 without affecting nitrate levels in breast cancer patients.
Tamoxifen protects against myocardial infarction through mechanisms that are poorly understood.
We studied the effects of tamoxifen and another antiestrogen, toremifene, on the production of vasoconstrictive endothelin-1 and of vasodilatory nitric oxide in 44 postmenopausal patients with breast cancer. Our data predict that toremifene and tamoxifen at the doses studied here will provide similar cardiovascular protection.