Even if the dog get wet occasionally, ProTICall retains most of its control. Program works as a insect growth regulator and does not actually kill adult fleas at all. Instead the active ingredient benzol phenyl urea lufenuron acts as a chitin synthesis inhibitor, causing mortality in hatching eggs and molting larva. Hatching fleas are unable to get out of their eggs due to the egg tooth not being formed due to the Adult fleas ingesting the IGR and thus passing on a genetic defect. The active ingredient Fripronil is a nervous transmission interrupter, causing rapid death to fleas and ticks.
Ticks die before attachment and repels further for up to three months.
The good news on Frontline is that it is safe for dogs, cats, kittens and puppies as well. The combination of these two compounds provides a convenient preventive medication for a variety of parasitic problems seen in dogs. It is a permethrin formula that kills and repels fleas, ticks, mosquitoes, and lice for four weeks. You apply it to the skin along the back of the neck once a month or after each bathing. The same with other topical insecticides, one vial is used on dogs under 33 lbs, and two vials for larger dogs.