You should be designing for the standards, not for specific browsers.
Standards are browser-neutral.
More information is available at the Viewable at Any Browser Campaign . This site, NewZilla, is designed towards the standards. This is not always the case, but descreppencies are minor the majority of the time. Problems can also be minimized with simple and efficient coding. If you want to be able to build your sites for multiple browsers using different Cascading Style Sheet files, you can use this wonderful piece of JavaScript provided by Netscape's DevEdge Online .