Occurs in shrub and brush habitats with moderate canopy-closure. Also inhabits open forest and woodland with scattered openings, and riparian habitats.
Spotted skunks are omnivorous.
Diet is primarily insects and small mammals, along with reptiles, birds, eggs, carrion, fruits, and grains. Forage on ground, dig in earth, occasionally climb into low trees and shrubs, and may forage in shallow water. Little information available. These skunks can live in dry areas, but may require drinking water. Lactating females in captivity drank daily.