The conversion of Factor X to Xa changes prothrombin into its active form, thrombin, which then accelerates the formation of fibrin. Clinical Features - similar to previously described thrombophilic defects A. Increased risk of venous thrombosis and pulmonary embolism.
Venous thrombosis occurs most frequently in the deep veins of the lower extremities.
B. Thrombotic events begin in mid-late teenage years. D. Cerebral vein thrombosis can occur. F. Arterial thrombotic events are not increased. Diagnosis and Treatment A. Diagnosis of the Prothrombin 20210 mutation is made by PCR analysis of the DNA from patients suspected of having thrombophilia. B. Treatment of Prothrombin 20210 Defect 1.