Thus, Natural Progesterone is safe for you to use in a very large therapeutic window. Large or small amounts are relatively safe. The cream can be applied to any part of the skin with good circulation. The area may be on the neck, chest, legs, arms, thighs, palms, or soles of the feet. The cream is applied once in the morning and once before bedtime.
Some patients experience mild drowsiness after application of the cream.
If so, one application before bedtime is fine. Since progesterone is an oil soluble molecule, it is absorbed into the body fat. The body fat acts like a reservoir or sponge and soaks up the progesterone. Thus, women who have much body fat may need to take greater amounts of progesterone for it to work. Skinny women may need to take less progesterone.