Stroke is the major cause of adult brain dysfunction.
TrkB immunoreactivity in scattered neurons, distant from the infarct, in ipsilateral and contralateral cortices at 24 and 48 h after MCA occlusion. We next studied the regulation of TrkB expression by BDNF, after ischemia, and its neuroprotective effects in vivo. TrkB immunoreactivity in neighboring astrocytes. Interestingly, ischemic animals grafted with the mock-transfected cell line did not show any further regulation of TrkB receptors. TrkB expression in neurons located in the internal border of the infarct.