The viremic phase generally marks the end of the infection but an occasional neurologic phase can lead to more severe and permanent problems. These viruses adsorb only to intestinal epithelial cells and motor neuron cells of the central nervous system. There are over 100 serotypes of Rhinoviruses and they produce the common cold. A variety of syndromes are possible, ranging from trivial to severe. Infection results via the nasopharynx by direct contact.
Viral replication leads to inflammation and edema, symptoms of the common cold.
Inapparent infection is common. Interferon is effective against these viruses. More specifically, IgA antibodies in the intestine and saliva are protective. Susceptibility to the Rhinoviruses is dependent on prior exposure. Antibody of the IgA and IgG classes is important.