Investigations include the cloning of previously unknown genes involved in lipid transport. HDL Deficiency States Deficiency of high density lipoproteins often is associated with substantially increased risk of arteriosclerosis. Studies are directed at disturbances of molecular structure and metabolism associated with HDL deficiency in individuals and affected families. The effectiveness of potential treatments is also under study. Disorders of Triglyceride and Cholesterol Metabolism Individuals and members of affected families in which abnormalities involving blood cholesterol or triglycerides are recognized are studied in order to find underlying genetic and biochemical abnormalities.
Studies are in progress to determine appropriate treatments for newly recognized disorders.