Use gene therapy to restore these genes. Increased amounts in the stromal layer of intestinal polyps in animals. MF-tricyclic inhibits polyp formation in mice with an APC defect. Want to develop agents that act as antagonists in breast and uterus but act as agonists in bone and heart. Estrogen agonist tamoxifen suppresses mammary carcinogenesis but is estrogenic in the uterus.
Tamoxifen also blocks formation of second primary tumors in the other breast.
New drugs like raloxifene prevents breast cancer in animals without effects on uterus. Also useful in preventing osteoporosis is postmenopausal women. Estrogen analogs also help to prevent prostate cancer. C. Retinoid receptors - 6 receptors that are transcription factors that regulate gene expression. D. Differentiating agents - cause differentiation of tumor cells and an inability for further growth.