The glutathione family of compounds and Taurine are important for liver detoxification reactions. Paradoxically, although Cysteine can be obtained from the diet, some researchers argue that the main source of cysteine used by the body in the production of glutathione is actually SAMe, and not cysteine. It should be added that at least some of the sulfur liberated by SAMe is contributed to the sulfuration of glucosamine and the chondroitin sulfates to produce the building blocks needed for the synthesis of cartilage, ligaments, tendons, the bone matrix, etc., that is, in all tissues that contain collagen and chondroitin sulfates. Spermidine and spermine are important polyamines which have roles in cell and tissue growth. An important, if indirect, function of SAMe in the body, therefore is the control of pain and inflammation.8 Usage and Safety SAMe is extremely safe and suitable for long term supplementation.
Side effects are extremely rare and appear to be limited to gastrointestinal disturbances.
The only contraindication that has been suggested to date is based on purely theoretical concerns, i.e., no clinical instances have been found. In clinical trials, a loading dosage of 1,200 mg is sometimes used for three weeks, and then a maintenance dose of 400 to 600 mg per day is followed References 1. Harpers Biochemistry, 24th edition. McCully, Kilmer S., The Homocysteine Revolution. Paul and Madsen, Fred, Stop Homocysteine Through The Methylation Process.