Many samples may be taken, depending on the size of the area. There is no special preparation. The procedure may be more comfortable if you empty your bladder and bowel beforehand. You should not douche or have sexual intercourse for 24-hours before the exam. A colposcopy is painless.
Some women feel a slight stinging sensation caused by the vinegar solution.
The biopsy may feel like a pinch each time a tissue sample is taken and may have some cramping with it. Any pain or cramping occuring during the biopsy may be helped by relaxing and taking a few slow deep breaths. This is usually performed after a positive pap smear to help identify the abnormality.