Whether people who are taking thioridazine for other mental health problems might benefit from niacin supplementation is unknown. Coenzyme Q10 Phenothiazine drugs like thioridazine can cause changes in heart activity in some people, which might be prevented with coenzyme Q10 supplementation. Therefore, some doctors and pharmacists may recommend coenzyme Q10 supplements to individuals taking thioridazine. One study reviewed four cases in which individuals stabilized on lithium medication developed side effects such as delirium, seizures, and abnormal electrical activity in the brain when thioridazine was added. 5 Further research is needed to determine whether similar side effects might occur in individuals taking thioridazine and supplemental lithium.
Vitamin C Taking phenothiazine drugs can stop menstruation in some women.
6 Controlled studies are needed to determine whether women taking thioridazine, who are experiencing menstrual changes, might benefit from supplemental vitamin C. Vitamin C might also enhance the effectiveness of neuroleptic drugs, such as thioridazine, in the treatment of schizophrenia . One uncontrolled study showed that 10 of 13 individuals experienced a reduction in disorganized thoughts, hallucinations, and suspicious thoughts when 8 grams of vitamin C was added to their daily drug therapy. 7 Controlled studies are needed to determine whether people taking thioridazine for schizophrenia might benefit from vitamin C supplementation. Effects of medication on plasma vitamin A concentrations. Ventricular arrhythmias associated with use of thioridazine hydrochloride in alcohol withdrawal.