Some additional studies are also concerned with contractile processes involving the cytoskeleton.
Most of my research involves the use of permeabilized cells of muscle which allow the investigator to control the intracellular concentration of ions, and proteins surrounding the regulatory and contractile proteins. In addition we are able to selectively remove regulatory proteins and to replace them with other regulatory proteins which have been genetically and modified or labeled with fluorescence probes. Collaborative studies with other investigators are concerned with the role of protein kinase C, cyclic ATP dependent protein kinase, caldesmon, IP3, diacylglycerol, and other regulatory factors play in the regulation of muscle contraction and cell motility. Pijuan V, Sukholutskaya I, Kerrick WG, Lam M, van Breemen C, Litosch.