It is consistently effective in treating pain associated with endometriosis. At this time, Danazol is not used much since equally effective medications are available and the side effects of Danazol can be undesirable. Most young reproductive age women find these sort of side effects to be highly unattractive and prefer to use one of the other available medications if medical management is chosen for treatment. There is no known benefit for the treatment of infertility associated with stage I or II endometriosis. Surgical considerations in treating the pain associated with endometriosis should encorporate what is known about the nerve supply to the affected pelvic structures.
Sensory nerves help to carry the signal of pain to the brain.
If there are no sensory nerves functioning in an area of the body then this area is incapable of feeling pain. The sensory nerve supply to the pelvis can differ in amount between different women. Surgical transection or removal of the nerves that carry pain sensation from the pelvic structures most commonly associated with endometriosis has been performed for some time. I have generally had good results with the aggressive removal of all visible foci of endometriosis. For women with little relief or recurrent endometriosis, the uterosacral ligament transection and presacral nerve ablation can be considered.