Women with CIN II or CIN III have a finite risk for progression to invasive cancer if these areas are not removed. Treatment for Adenocarcinoma in Situ . Some controversy exists over the treatment of adenocarcinoma in situ. Adenocarcinomas originate in glandular cells. This cancer tends to be more aggressive than the more common squamous carcinoma in situ.
Some evidence suggests that it develops in numerous sites rather than a single location.
Hysterectomy is generally recommended. In women who wish to retain fertility, cone biopsies may be performed, although this procedure sometimes causes sterility and it does not always remove all adenocarcinomas. A local anesthetic is applied to the cervix, and a wire loop is inserted into the vagina. A button-sized slice of tissue is removed from the cervix for examination. A deeper slice is used to evaluate the endocervical canal.