Few of the current options are completely avoided due to side effects, and even our best options might have side effects in some. One key issue that makes this complex is that there is an unpredictable component of side effects. On the other hand, as an example of this variability, one of the men I care for finds on that same dose he gets no nausea at all even when taken on an empty stomach. And there is no way to predict in advance who will feel well, versus who will have a side effect. So we deal with averages, keeping in mind that this is only of some help.
Some issues are more clear.
In addition, many although not all studies suggest that there is some contribution of some if not all of the nucleoside antivirals in fat loss, and that there are differences observed between the meds in how much this happens. The idea here is to have some periods of time when the meds are stopped and hopefully give our cells a rest from whatever these side effects are, while keeping the CD4 count out of the danger zone. The time off can vary from a week to years depending on the approaches being taken - and so far no right answers to this new strategy. But all of these strategies start with someone whose viral load is suppressed initially. And that means putting your nickel down somewhere.