These symptoms are reversible. Cisplatin causes a large-fiber sensory neuropathy by damaging dorsal root ganglia. Symptoms often begin several weeks after completion of cisplatin therapy and progress for several months. Loss of proprioceptive sensation may be severe enough to prevent the patient from walking and effectively using his or her hands. Pinprick and temperature sensations are normal, and motor power is spared.
Some patients recover.
Proximal muscle weakness may complicate the disorder. The neuropathy may resolve even with continuation of therapy and is rarely a disabling problem. Respiratory muscles may be affected. The myopathy usually resolves when the drug is discontinued. High-dose cyclophosphamide is sometimes associated with acute delirium.