The administration of Tham also increases urine output through osmotic diuresis. Excretion of electrolytes and CO 2 is also increased. Tromethamine is indicated for the correction of metabolic acidosis. Most reported adverse reactions are local and occur from the administration of an alkaline solution. Local adverse effects may include irritation at the injection site, chemical phlebitis, and venous thrombosis.
Subsequent doses are base on additional laboratory values and patient condition.