This study investigates the effects of exogenous testosterone administration on immunological parameters which may underlie the pathogenesis of Alzheimer s Disease. This research project addresses molecular pathogenesis of one of the major age-related diseases, postmenopausal osteoporosis. The study focuses on phenotype expression by osteoblasts at the gene transcription level. Parathyroid Hormone Induces Novel Primary Response Genes in Osteoblasts Sotirio Tetradis, DDS, PhD, Principal Investigator Parathyroid hormone has been shown to have anabolic effects on bone metabolism and has been used with promising results in the treatment of bone diseases of the elderly, such as osteoporosis. Understanding the molecular basis of the effects of parathyroid hormone on bone quantity and quality might allow the design of more effective pharmacological interventions and ultimately lead to improvements in clinical outcomes.
Sex hormones have profound influences on many aspects of health and disease.
This study will investigate the expression and function of estrogen receptors on T lymphocytes and immune function. Investigating Nutritional Care Staffing in Nursing Home Rebecca D Amato, PhD Operations Research Associate, RAND Corporation Undernutrition among nursing home residents has been associated with poor health outcomes, including death. While nursing home staff members may provide assistance to residents to increase their nutritional intake, insufficient staff capacity may lead to unacceptable abbreviation or omission of this labor-intensive task. This study will aim to develop a model that explores the impact of staffing ratios on patient time spent waiting to receive nutritional care. MD Assistant Professor of Medicine Diabetes, a highly prevalent condition among the elderly leading to functional decline, can be influenced by behavior change and self-management skills.