Since the introduction of PIs, a greater awareness of the relationship between optimal suppression of viral replication, genotypic resistance, and viral rebound has led to the design of more potent antiretroviral drug combinations. Although this drug combination is logical, there is limited PK data to guide the dosing selection. Before each PK testing, volunteers complete an Adherence Questionnaire.
Volunteers maintain a food diary.
14 volunteers will be enrolled in each of five arms. No reproductive potential, if a woman, defined as post-menopausal or surgically sterile by hysterectomy, bilateral oophorectomy, or tubal ligation as documented by medical records. Within normal limits. Within normal limits. Within normal limits.