Spaying and Neutering Female bunnies MUST be spayed. A leading cause of death in female bunnies is cancer of the uterus. This cancer is completely preventable by having the bunny spayed between 6 months and 2 years of age. This procedure also helps prevent the occurrence of breast cancer later in life. Rabbits have very active sexual drives and it takes only a moment for a male to impregnate a female.
Some male bunnies become very aggressive when they reach sexual maturity.
This may include biting and the spraying of urine. The best solution for these behavioral problems is neutering. This procedure is recommended any time after 5 months of age. Neutered rabbits are healthier, calmer, and easier to housetrain, less aggressive and less destructive.