MDMA causes the brain to release all of its neurotransmitter serotonin at once, causing a sense of profound well-being and love for all, combined with agitation, energy, altered visual perceptions and heightened tactile sensation. Effects wear off after 4 hours. In rare cases, dehydration, seizure and hyperthermia, leading to strokes, heart attack or death. Dangerous side effects can intensify when mixed with other drugs or alcohol. MDMA users may experience post-use depression, panic attacks, insomnia or anxiety.
Users can develop a tolerance to the drug or psychological dependence.
Long-term use has been connected with memory impairment and mood disorders due to damage to the nerve endings that release serotonin. Investigated by a German pharmaceutical company in 1912 for medical use, never marketed due to adverse side effects. It is not legal anywhere in the world. Explored in 1970s as a marriage therapy tool in the United States. Made illegal and put into most serious class of narcotics in 1985.