Adrenergic side effects such as postural hypotension and sinus tachycardia tend to diminish with continued dosing. Extrapyramidal symptoms do not exceed those of placebo. There appears to be no tendency to increase or initiate tardive dyskinesia or akathisia. There is some evidence to suggest short-term prolactin increases in some, patients. These are not generally clinically significant.
Weight changes are of major concern to many patients taking antipsychotics.
The QT interval on ECG may be prolonged. Cautions Sertindole is contraindicated with drugs known to prolong the QT interval like terfenadine, astemizole, thioridazine, quinidine, procainamide, betrylium, sotalol, tricyclic and teteracyclic antidepressants. Administration is once daily. Update Presentations on Sertindole from the Lundbeck Schizophrenia Congress, Vittel, France, September 24th-26th 1996. The novel antipsychotics had therefore a goal of a separation between the dose-response curve for antipsychotic and EPS inducing curves.