Test code links throughout this Guide refer to the corresponding test in the User's Guide. These include aseptic meningitis, encephalitis, flaccid motor paralysis, exanthems, generalized disease of the newborn, and neonatal diarrhea. Because of the large number of potential serotypes, serology is of limited use in diagnosis.
Viral isolation is the preferred laboratory method.
A fourfold or greater rise in titers in sera bracketing the illness is much more convincing proof of disease association. In Manual of clinical laboratory immunology , 4th ed. NR Rose, et al, eds. In Manual of clinical microbiology , 7th ed. PR Murray, et al, eds.