Problem Statement Quantitative reliability measures for software remains an elusive goal.
Software systems continue to be a major source of security and safety catastrophes.
To make matters worse, software systems are growing in size, complexity, and importance. We are becoming more reliant on software systems in our everyday lives. Furthermore, software systems are increasing in vulnerability to malevolent attack. The Systems Immunology TM research contains low-risk, medium payoff activities and is innovative in nature in addressing today's problems with immediate application and realization of benefit for high consequence operations. This area has a systems immunology focus and will produce methods and techniques to render today's systems safer, more secure and reliable.