Because an enzyme that acts on many other drugs metabolizes sildenafil, there is the potential for many drug interactions. Some drugs that may increase the levels of sildenafil in the body are the antibiotic erythromycin, several protease inhibitors used in the treatment of HIV , some drugs used to treat fungal infections , and several antidepressants. It is important to discuss the potential for side effects alone or with any other medications you are taking with your physician. In this usually congenital condition, the opening of the prepuce is too small for retraction over the glans penis. Forcible retraction of the foreskin may lead to constriction, swelling and pain of the glans penis.
Treatment is usually circumcision.
Success is dependent on the presence of a normal supple foreskin and parental compliance. Hypospadias This congenital anomaly results from improper development of the external genitalia. The urethral opening is located on the underside of the penis. This condition is also associated with undescended testicles and curvature of the penis. Surgical repair is to straighten the penis and locate the urethral opening centrally, if possible.