Pancreatitis is an inflammation of the pancreas, an abdominal organ that produces digestive enzymes. The condition has been most often associated with ddI. Severe inflammation of either the liver or pancreas may be fatal. Kidney stones are accumulations of material such as drug crystals in the kidneys and urinary tract. They are characterized by severe back or groin pain. Kidney stones have been associated with the use of indinavir.
Some side effects affect the nervous system.
Peripheral neuropathy is damage to the nerves, most often in the feet and hands, but sometimes also in the legs, arms and face. Such nerve damage may lead to tingling or burning sensations, pain or numbness. Peripheral neuropathy may also result in weakness or partial paralysis. The condition is most often associated with the use of ddC, ddI and d4T. Paresthesias are unusual sensations such as prickling or tingling. Tingling around the mouth is associated with the use of ritonavir.