We are all guilty in God's eyes and worthy of hell and eternal damnation because of the sin we are born with as well as the sin we actually commit. This guilt is removed and replaced with righteousness because of the death and resurrection of Jesus. This we know as justification. The second effect of sin is pollution. We are all born with sin, the curse of sin, the effects of sin.
Sin is to be found in every part of our existence.
This pollution of sin is removed in sanctification by the operation of the Holy Spirit. The doctrine of sanctification means that God's Holy Spirit has a goal in mind for us saints, for each of us who are God's children. It is a grand, sweeping, wonderful goal. It is a goal impossible for man on his own to accomplish. The Holy Spirit's goal for our life is perfection.