The object is to arrange falling vitamins one by one, stacking them in columns inside a pill bottle. If you chain four same-colored vitamins, they vanish and a virus is destroyed. In a typical game, you destroy 10 viruses to win. At first it's simple, giving you plenty of time to think and arrange the vitamins. But the action steadily picks up.
Vitamins come faster and faster.
The only twists are a few new formats in which to play. There's a story mode, too. It's flu season and someone is trying to steal Mario's mega-vitamins. To move the story forward, you must defeat opponents by clearing all the viruses before they do. But the story is pretty lame, with two-dimensional characters confined to a tiny portion of the viewing screen.