Those who have been vaccinated, but more than 5 years previously, should receive a single booster dose of vaccine. Prophylaxis should be given as soon as possible, at least within 48 hours after exposure. After 48 hours the efficacy of prophylaxis drops markedly and protection will only be partially successful. There is little value in prophylaxis after 10 days after exposure. Subsequent doses should then be given a month later and 6 months later.
Vaccine is given intramuscularly in the deltoid region.
Antiretroviral therapy should also be commenced as soon as possible. Subjects should be monitored at 2 weeks with a full blood count and liver function tests. A reductase inhibitor used for lowering cholesterol. This agent is structurally distinct from the other cholesterol-lowering agents, pravastatin, lovastatin, and simvastatin, all of which are derived from a fermentation product of Aspergillus terreus . Synergy studies with amphotericin B demonstrated an additive effect.