MSH, ACTH and b -lipoprotein are able to influence skin pigmentation. Melanocytes express numerous receptors that allow interaction with other cells in their microenvironment, including keratinocytes and the immune component of the skin Langerhans cells . The inherited disorders of keratin include epidermolysis bullosu simplex causing cell degeneration within the basal layer. Sunlight and ultraviolet radiation from artificial light sources could be tonic or toxic to human skin. The harmful effects of solar radiation are skin cancer, photosensitivity diseases, sunburn, photoallergy, photoimmunologic alterations, cataracts, mutations, skin aging and phototoxicity.
Sunscreen chemicals protect the skin against ultraviolet radiation.
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