Although usually asymptomatic, sarcoidosis granulomas are often scattered throughout the spleen. Liver Up to three-fourths of patients develop granulomas in the liver that rarely create symptoms. Granulomas in the liver can also be due to cirrhosis, tuberculosis, and Hodgkin s disease. Neurological symptoms Sarcoidosis can affect any part of the nervous system. Granuloma involvement in the hypothalmus can lead to diabetes insipidus.
Sarcoidosis can also lead to obstructive hydrocephalus.
Like many other organs, sarcoidosis granulomas on the heart are usually asymptomatic. Heart problems can arise, however, usually as secondary complications due to granulomas in the lung. At its worst, sudden cardiac arrest can occur. Bones, joints, and muscles Bones, joints, and muscles can be affected by sarcoidosis. The bones in the hands, feet, and nose may be affected and the joints in the hands and feet may swell.