As PI of the local site, I serve on the national steering committee to develop projects suitable for large multicenter clinical trials in this important disease. ALA and local funding. Promising new animal studies indicate that retinoic acid may be useful in the treatment of emphysema. Together with Columbia, we have been named as one of five nationwide centers to develop a clinical protocol to determine if retinoic acid has a role in treating emphysema. I serve on the national steering committee for this project and am engaged in developing several substudies.
Scorpion venom leads to gastrointestinal ischemia in spite of increased oxygen delivery in pigs.
Effect of chronic resistive loading on hypoxic ventilatory responsiveness. Effects of periodic obstructive apnoeas on superior and inferior venous return in dogs. Comparative hemodynamic effects of periodic obstructive and simulated central apneas in sedated pigs. Scharf SM , Rossoff L, Graver LM, McKeon K, Graham C, Steinberg H. Changes in pulmonary mechanics following lung volume reduction surgery. Right ventricular overload causes the drop in cardiac output following nitric oxide synthesis inhibition in endotoxemia.