Prior surgical resection is permitted. Patients will undergo exploratory laparotomy with a total omentectomy and total excision of all visible peritoneal, retroperitoneal and pelvic disease. Patients will then be treated with intraperitoneal chemotherapy over a three to six month period followed by second look surgery. At the time of the second surgery patients will receive intraoperative heat treated chemotherapy. Radiation therapy will follow the second look surgery.
Trial is currently under development and projected to open shortly.
These treatments will take place at twenty-eight day intevals. Phase II Study in Collaboration with the Southwest Oncology Group of Gemcitabine and Cisplatin for the treatment of Pleural Mesothelioma. Unresectable malignant mesothelioma of the pleura. No prior chemotherapy . No prior radiation therapy Patients will be treated on an outpatient basis with both intravenous Gemcitabine and Cisplatin.