Early recognition, empirical treatment with antibiotics, and surgical debridement is essential for lower morbidity and mortality. Ideally, first-line therapy for diaper dermatitis is zinc oxide ointment. The safest OTC emollient available for newborns is pure white petrolatum ointment. It is more expensive than pure white petrolatum ointment. Plays significant role in wound healing with low risk for allergic or contact dermatitis.
Zinc oxide is easier to clean with mineral oil than soap and water.
Commonly used topical antifungal agents are nystatin cream or ointment and econazole nitrate cream. Effective against various yeasts and yeastlike fungi. Changes permeability of fungal cell membrane after binding to cell membrane sterols, causing cellular contents to leak. Interactions None reported Pregnancy C - Safety for use during pregnancy has not been established. Interferes with RNA and protein synthesis and metabolism.