In cases where the disorder progresses to a chronic condition, the prognosis is less favorable. This condition involves brain degeneration and is a difficult process to reverse. Early diagnosis and treatment greatly improves the prognosis. Genetic factors often play a significant role in the development of schizophrenia. Spinal injury and other forms of somatic dysfunction are important etiological factors in the production of psychotic symptoms.
Stress is often an important etiological factor in the production of schizophrenic symptoms.
The human body contains interfaces with spiritual and mental dimensions of reality. Chemical imbalances or injury to these systems can disrupt these centers producing the psychotic symptoms associated with schizophrenia. The treatment of schizophrenia requires a holistic perspective which typically involves spiritual, mental, and physical interventions. These therapies include osteopathic or chiropractic treatments, massage, electrotherapy, diet, companionship, therapeutic milieu, hypnotic suggestion, exercise, and pharmacology. Cayce's holistic perspective involves spiritual and metaphysical constructs such as karma and spirit possession.