The heart finds it difficult to keep up with your body's demand for blood when you exert yourself. When amyloidosis affects the electrical system of your heart, your heart's rythym may be disturbed. Amyloid also may affect your nerves. This occurs when the nerve that supplies the fingers is compressed. This may cause pain, numbness and tingling of the fingers.
Symptoms are particularly worse at night.
You may require wrist surgery to relieve pressure on the nerve that supplies the hand. This often provides significant relief. When amyloid deposits in the nerves to the feet, you may experience numbness, lack of feeling in the toes and soles of the feet, or burning sensation due to nerve irritation. Over a period of time, this can make both legs weak. Sometimes amyloidosis affects nerves that control bowel function resulting in periods of alternating constipation and diarrhea.