Body weight and food intake were quantitated. Ten weeks after inoculation, the study was terminated, primary tumors were weighed, and lymph node metastases were observed. Dietary soy products did not significantly alter the food intake or final body weight. Dietary soybean components had no significant effects on serum insulin-like growth factor 1 or testosterone levels. Orthotopic growth and metastasis of prostate tumor in the SCID mouse provides a clinically relevant animal model for studying the effects of dietary treatment on growth and metastasis of prostate cancer.
Soy products warrant further investigation in prostate cancer treatment and prevention.