In the cover letter, list the position title and the HNV number. Minorities, women, and handicapped individuals are encouraged to apply. Positions are open until filled. Study of the regulation of gene expression during differentiation and the mechanism of action of retinoids is being conducted. The role of nuclear receptors and other transcriptional factors in the control of gene transcription is being investigated.
Studies involve characterization of promoters of several genes.
Applicants must have experience in molecular biology techniques. We use fluorescent substrates, confocal microscopy, and image analysis to characterize xenobiotic transport mechanisms in renal and nonrenal epithelial tissues. The focus is on understanding the specificities, energetics, and regulation of both plasma membrane transporters and intracellular mechanisms, such as vesicle-mediated transcytosis. Experience in the biochemistry and physiology of membrane transport is expected. The signal transduction pathways regulating the expression of neuropeptide and cytokine genes in neural and glial systems are being investigated.