Booster Doses Booster doses may be given every 6 months if necessary for travel or for residence in highly endemic, unsanitary areas. In areas where cholera occurs in a 2-3 month season, protection is best if the booster dose is given at the beginning of the season. The primary series does not need to be repeated for booster doses to be effective. Vaccination often results in 1-2 days of pain, erythema, and induration at the site of injection. The local reaction may be accompanied by fever, malaise, and headache.
Serious reactions following cholera vaccination are extremely rare.
If a person has had a serious reaction to the vaccine, revaccination is not advised. However, some countries may quarantine such unvaccinated persons or place them under surveillance if they come from areas with cholera. No specific information exists on the safety of cholera vaccine during pregnancy. Its use should be individualized to reflect actual need. Brennemann's practice of pediatrics.