The thrower attempts to lead the deep runner. If possible, thrower should make some fakes first. Works on timing and communication between thrower and receiver. Thrower has to lead catcher. Thus, weaker throwers should throw very early, and forget about trying to throw all the way into the end zone.
Stronger throwers can wait longer.
Faking will prevent the thrower from setting up properly. Thrower can line up at center field as well. A1 cuts, B1 throws and then immediately cuts for A2's throw. Meanwhile, A1 clears to back of B stack. Lots of teams use it.