I'd rather not do that if at all possible. Paleface Dear Paleface, You do have significant anemia. You should work with your physician to find the exact cause or causes. It is doubtful the nelfinavir would cause this type of side effect. Treatment of your anemia is definitely warranted.
Transfusion is an option but it does carry some risks.
You should talk with your doctor about switching off combivir. You could consider D4T, 3TC, and stay with Nelfinivir if you're otherwise doing well on this combination. In addition you could try Procrit 40,000 units injected once per week. It will take several weeks for this medication to kick in. However it is safer than a blood transfusion.