The disorder affects mostly people under age 50. Membranoproliferative GN 1 may present in several forms. The glomerular membrane disruption causes a change in urine filtration, making the glomerulus permeable to protein and blood cells. This is manifested as acute nephritic syndrome , nephrotic syndrome , or abnormal urinalysis without symptoms. White blood cells may be excreted in the urine, causing it to have a cloudy appearance.
Urine output decreases because of reduced glomerular filtration rate.
Swelling may occur as sodium and water are retained in the body. Protein in the bloodstream keeps fluid within the blood vessels. Edema is increased when protein is lost because fluid leaks out of blood vessels into the tissues. The disorder is often progressive and eventually results in chronic renal failure . Prevention is often not possible.