The action of aspirin is also supported by studies on an anti-inflammatory agent, sulindac, which causes regression of benign tumors. However, with chronic aspirin use, there may be increased gastrointestinal irritation and bleeding. If confirmed, this new generation of selective COX-2 inhibitors may work to prevent cancer with fewer side effects. A mildly to moderately elevated blood homocysteine level is a substantial risk marker for death from all causes. An increase in mortality hazard ratios was associated with rising homocysteine levels.
Soybeans are unique among beans because they are a concentrated source of isoflavones.
Isoflavones are weak estrogens, such as genistein, which influence the transmission of signals. Soyfoods and isoflavones have received considerable attention for their potential role in preventing and treating cancer and osteoporosis. The low breast cancer mortality rates in Asian countries and the anti-estrogenic effects of isoflavones suggest that soyfood intake may reduce the risk of breast cancer. Recent data support this hypothesis, including the risk of postmenopausal breast cancer. The lower mortality from ischemic heart disease among vegetarians was greater at younger ages and was restricted to those who had followed their current diet for more than 5 years.