I find I must screen all phone calls and, on occasion, refuse to answer the door to minimize the interruptions. Also, family members constantly are asking me to run errands, etc., that they can't attend to because they're working. I do try to accommodate these requests as much as possible if they will not significantly affect my ability to get the work done. At times, balancing work and home responsibilities is my toughest personal obstacle. My son is only 3 and requires a lot of hands-on supervision.
Work has to come first.
I can definitely say my house is quite a bit messier than when I used to work outside the home. In my opinion, however, this is a small sacrifice compared to the benefits of working at home. I had no idea what this would be like, and it was a very difficult transition. Once I made the transition and had renewed confidence in my abilities, things went much, much smoother. It is very hard at times with all the interruptions, family obligations, and job pressures to keep yourself sane and to get enough rest.