It may infect the brain, heart, eyes, nerves, and bones. Many years later, the person may develop tertiary syphilis. Primary syphilis can cause one or more painless ulcers, or sores, at the point where the bacteria entered the body. These sores are usually on the genitals. They may also be found around the anus, in the rectum or vagina, on the lips, and in the mouth.
Secondary syphilis involves a generalized rash that usually appears on the palms and soles.
The usual rash appears as red spots that can be flat or raised. However, many different skin rashes can occur. Sometimes people can develop meningitis , which is an inflammation of the membrane lining the brain and spinal cord. Secondary syphilis may cause may cause eye, kidney, or liver problems. Tertiary syphilis can involve any organ of the body.