No clinical history is provided. Review of outside material. No surgical pathology report is received with the specimen. The normal lobular architecture is mildly distorted because of mild portal expansion because of edema, minimal fibrosis and a mild inflammatory cell infiltrate, focally enriched with neutrophils. There is duct and cholangiolar proliferation and acute inflammatory cells can be seen in between the biliary epithelial cells and in the ductal lumen.
Similar changes are present in a small septal duct at one end of the needle core.
This portal tract in particular shows periductal edema and a neutrophilic and eosinophilic inflammatory response. Throughout the lobules, there is marked centrilobular hepatocanalicular cholestasis and Kupffer cell hypertrophy. Occasional acidophilic bodies are seen, but these are not plentiful. No viral inclusions or ground glass cells are seen however, there is an increased mitotic rate within the lobules, which is suggestive of recent hepatocellular turnover. Prominent pigment deposits are present.