Thicker film columns have higher solute capacities. When one solute is present in significantly higher amounts, the resulting broad peak may interfere or co-elute with an adjacent peak. Changing to a thicker film column may reduce peak broadening, thus co-elution. Table 6 lists typical capacity ranges for a variety of film thickness. Column Film Thickness Selection Summary 1.
Thick columns are more inert and have higher capacities.
Thick film columns exhibit higher column bleed and decreased upper temperature limits. Thin columns are less inert and have lower capacities. Thin film columns exhibit lower column bleed.