M.D. It now appears that infections are a major cause of kidney stones. Doctors failed to find infections in kidney stones before because nanobacteria are so small that they cannot be seen by conventional microscopes, but can be seen through the super powerful electron microscope, they do not stain with conventional bacterial stains and they do not grow in conventional laboratory agar and grow very slowly on special media. Nanobacteria cause calcium, phosphorus and other minerals to form carbonate apatite as a shell around them, that is a major component of kidney stones. Antibodies that bind to nanobacteria have been found in all 30 stones tested.
Tetracycline antibiotics accumulate in the calcium shell, and have been shown to kill nanobacteria.
There are no studies to test whether daily intake of doxycycline prevents kidney stones, but these tests should be started soon. I treat my patients with kidney stones with doxycycline 100 mg twice a day for many months. A Yuce, M Yucesoy, K Yucesoy, T Canda, M Fadiloglu, A Gure, N Yulug. Ureaplasma urealyticum induced urinary tract stones in rats. Proceedings of the National Academy of Sciences.