Field theory, Quantum mechanics, Thermodynamics. The list is endless. All these subjects are abstract representations. Students learning them are required to place themselves in hypothetical positions, and imagine the dynamics of the system. An artificial imagination would be invaluable for the study and investigation of these disciplines.
Several problems exist.
Many of these unexploited subjects include representations which require the definition of dynamic objects, normally surfaces. Current VE toolkits do not strongly support objects which change geometry. Hopefully this will change. A more fundamental problem is created by the nature of these subjects. The mathematical definitions are complex, requiring massive computation.