Bupropion has been associated with a number of other neuropsychiatric signs and symptoms, such as delusions, hallucinations, psychotic episodes, confusion, and paranoia. Causal effect may be uncertain as trials were not always conducted with adequate controls. However, some effects are found to resolve upon dose reduction or discontinuation of therapy. Other neurological adverse events include headache, and tremor. Bupropion appears to initiate weight loss.
Weight loss contrasts with a high incidence of weight gain for tricyclic antidepressant use.
Bupropion has some anticholinergic effects. Constipation is another frequent adverse reation. Some patients reported dysgeusia. Twice as many patients taking bupropion reported libido decrease compared to patients taking placebo. Other adverse reactions that occur infrequently with bupropion use include pruritus, and maculopapular rash.