Vascular diseases represent one of the major cause of morbidity and mortality in western countries.
Ischemic diseases are mainly due to thrombotic events, aterosclerosis, or other phenomena such as restenosis after angioplasty. In addition, vascular changes leading to neovascularization are observed in most solid tumours, which require new blood vessel formation to support cancer growth. Therefore, molecules active in controlling the growth of vascular cells and vessel walls, are largely investigated for the potential benefit in a variety of socially relevant diseases. The aim of the current project is to design active peptidomimetic molecules by using peptides, known to be active, as template . The effectiveness of the designed molecules will be validated by synthesising them and performing biological tests in vitro.