E. Any unusual spells of confusion. F. Headache especially if with stiff neck. On X-ray using a barium exam, the findings may mimic acute Crohn's disease with aphthous ulcers, collar button ulcers, or a granular appearance to mucosa. The GI involvement can range from a mild inflammation of the rectum to include the total colon and the esophagus. Complications may include perforation, a fistula formation and hemorrhage.
Treatment is symptomatic and empirical.
In cases of skin involvement, vasculitis or the eye disease, uveitis, steroids are usually used. However in cases of posterior uveitis, CNS involvement or arteritis, a combination of steroids and chlorambucil is recommended. Indomethacin has been tried and reduced the severity of joint inflammation and pustular skin lesion but controlled studies are needed. There are early reports of the beneficial use of cyclosporine A in uveitis.