An address like william179blinn would be virtually impossible for anyone to construct but would also be ugly. So there's no good to be gained by insulting the person you complain to. Those you're complaining to will almost always want to make their servers unavailable to spammers if for no other reason than the spam traffic slows down their networks. In many places, the same person receives mail to either address. I'm less interested in the e-mail account, though, than in the Web site.
Spammers simply open a new e-mail account or steal services from another open relay.
The best thing, if they mention a Web address is to get that shut down. Note, though, that some spammers list Web sites that aren't theirs in the spam. Their goal is to send you after the wrong person. Before you report a Web site, make sure it really belongs to the spammer. Keep moving upstream until you find somebody who cares.