In private-label nutritional supplements, where container runs can be extremely small, the redesign of a label or even just a tiny alteration to it was once prohibitively expensive in relation to sales. You can go as elaborate as you want, and it won't cost you nearly as much as traditional printing. People who buy small units will benefit most. I can tell my smaller customers to go nuts with their design. But it might be at 5000 to 10,000 pieces, depending on how elaborate the design is.
Setup time is nonexistent on the digital side.
For private-label products, there's usually not a lot of advertising behind them. They often have to catch the shopper's attention without the benefit of a national advertising campaign. In fact, there are examples of private-label products leapfrogging the national brands in package fabrication. We continue to use 16-point solid bleached sulfate paperboard, while some of the national brands are using inferior board. This helps sell my clients' products.