Introduction to Immunology Tutorial Introduction to Immunology Problem 7. IgE IgE binds to the surface of a class of white blood cells called mast cells. The presence of antigen that binds to the IgE leads to the release of granules by the mast cells that contain a number of mediators of inflammation, including histamine.
Some humans are more likely to make an IgE response to non-pathogenic antigens, including pollens.
These individuals suffer from allergies caused by IgE-stimulated mast cell degranulation. All rights reserved.