Vesicles appear inside the mouth on the tongue, cheeks and gums, lips and palate. Vesicle may form between the claws of the feet and along the coronary band. Mortality in adults is usually very low. In pigs, the main sign is lameness. There is also fever and loss of appetite.
Vesicles form along the top of the foot, on the heels and between the claws.
Vesicles may also be form on the snout, but tend to rupture quickly. Abortion is common. Mortality in piglets can be high In sheep and goats, the disease is usually milder with fewer lesions. Affected sheep are depressed and reluctant to stand. Some animals may get a sudden lameness.