In the sorghums, leaf blades normally contain higher prussic acid levels than leaf sheaths or stems, the heads are low in prussic acid, and the seeds contain none. Upper leaves have more prussic acid than older leaves. Highest prussic acid levels are reached before the boot stage. As plants mature, the stalks make up a greater proportion of the plant, causing prussic acid content in the total forage to decrease. However, the hazards associated with poisoning may decrease only slightly with age if animals selectively graze those plant parts that are high in prussic acid.
Severe drought is probably the most common cause of prussic acid poisoning.
Drought-stricken plants are hazardous to feed because they are mostly leaves. Sorghum grazed or fed as green chop in the heart of a drought may retain high levels of this poison. Cold weather may kill only the tops of sorghum plants, leaving the lower portion alive. The unbound prussic acid in this forage does not decline until wilting begins. The forage is usually considered safe to pasture or feed as green chop 5-6 days after a killing frost.