Make unavoidable changes as gradual as possible. Avoid if possible. Generally, they are preferred to uneven walls. Tiny through holes are expensive to tool and produce. Be as generous as possible.
Sharp corners are difficult to extrude and provide stress risers.
The tighter they are, the more expensive the extrusion. Indicate the truly important dimensions. Show how the part will be used. Some materials are easier to extrude than others. Some are more forgiving when design rules are broken.