Automated Prep Purifications PDR-Chiral has developed a software and hardware system that can automatically control purification valve timing during chiral separations. The software normalizes and synchronizes the UV and ALP signals, and then divides the resulting ALP signal by the resulting UV signal. The resulting function always has an absolute value less than or equal to 1. This results from the fact that the UV signal is the sum of the 2 enantiomers while the ALP signal is the difference of the 2 enantiomers.
Users can adjust the range of the acceptance windows to optimize, for example, purity vs throughput.
The resulting system is easy to use and intended to operate automatically and unattended for long periods of time. The improvements to overall purification efficiency are typically dramatic.