However, this carries the risk of virus transmission. A single infusion is enough to control mild bleeding. If bleeding persists, repeat the infusion every 12 hours. If neither of these modalities works, consider platelet transfusion. Rare Defective activation or secretion .
Storage pool defects.
Can treat these with platelet transfusion. Bleeding caused by quantitative platelet disorders. In these states platelets are often poorly functioning with abnormal aggregation leading to a bleeding disorder. Causes include decreased production, increased splenic sequestration, or increased platelet destruction. Infiltration secondary to malignancy or fibrosis.