Although aggressive surgical intervention is required, patients also should receive adjuvant antifungal therapy. Antifungals - Their mechanism of action may involve an alteration of RNA and DNA metabolism or an intracellular accumulation of peroxide that is toxic to the fungal cell. Drug resistant species of have been isolated in patients receiving prolonged therapy. Serial imaging and evaluation is preformed as needed to assess the extent of the disease and to decide if reoperation is necessary. After amphotericin B is discontinued, close assessment for recurrence needs to be performed.
Treatment often is long term and disfiguring.
Closely manage the patient's underlying medical condition and medications. Reconstructive surgery, if necessary, can be considered only after complete resolution of infection. Over the last 40 years, prognosis has improved greatly. Immediately evaluate patients at risk if any signs or symptoms develop. The clinician must retain a high clinical suspicion for mucormycosis in patients at risk.