Nutritional factors may also play a role. Deficiencies of vitamin B12, folic acid, and iron may play a role in the cause of RAUs. Forms of treatment vary. They are certainly not cures. Since an immunological cause seems likely, regulation of the immune response may be the most successful treatment.
Topical corticosteroids are generally sufficient for effective treatment.
In patients who are severely affected, systemic corticosteriods may be necessary. For individual, persistent lesions, intralesional injection of a drug called triamcinolone may be helpful. Systemic steroids should be carefully administered. Immediate control of severe RAU can be gained by use of low to moderate dosages of prednisone. Other types of drugs, such as antibiotics, anti-inflammatories, and retinoids, may also be beneficial.