Although such a risk is not verified for roxithromycin, combination of roxithromycin with such drugs is not recommended. It is prudent practice to monitor INR during combined treatment with roxithromycin and vitamin K antagonists. Consequently ECG and. if possible, disopyramide serum levels should be monitored. Caution should be exercised with patients receiving concomitant theophylline therapy as roxithromycin may increase serum theophylline levels, which may lead to theophylline toxicity. Concomitant administration of roxithromycin and ranitidine does not alter the pharmacokinetic parameters.
Treatment is symptomatic and supportive.
Blister packs of 10 and 100 tablets. Protect from light. Keep out of reach of children.