Cross cell membranes easily. Iodine-containing molecules derived from tyrosine. Biosynthesis of Hormones. Synthesized on rough endoplasmic reticulum . Initially synthesized as larger protein molecules, called preprohormones , based on the nucleotide sequence of a specific gene.
Synthesis takes place through the processes of transcription and translation.
Signal peptide is removed by enzymatic action. Remaining protein is called a prohormone. Protein precursor to a peptide hormone or hormones. Packaged into secretory vesicles. Prohormone is enzymatically cleaved within secretory vesicles, yielding one or more hormones and other peptide fragments.