Tissue damage is widespread. Get an intense cellular infiltration. Get goiter and then atrophy. Iodine uptake decreases. Get unregulated, overstimulation of the thyroid.
T cells infiltrate the pancreas and destroy the beta-cells in the islets of langerhans.
Antibodies are also involved. Virus infection may precipitate. T-cells attack the myelin sheath of nerve fibers resulting in progressive muscle weakness and visual disturbances. Complexes accumulate in the joints. Joint cartilage destroyed.