I Allergic Response Allergic response Anaphylaxis IgE binds to mast cells, histamine released. IgE involvement leading to an immediate systemic response and histamine release. Asthma with bronchial constriction and edema Histamine release causes widespread edema and vascular congestion.
Vasodilation leads to hypovolemic shock.
Type II Cytotoxic Response Transfusion reaction Antibody in donor blood attaches to RBC, making it a target for the immune system. IgG and IgM cause direct cell damage. As the RBC is destroyed, hemoglobin is filtered through the kidneys. Type III Immune Complex Response Arthus vasculitis Organ damage of SLE Glomerulonephritis Ulcerative colitis Hyperacute graft rejection Chronic graft rejection IgG and IgM bind to antigens in epithelial lining of blood vessels. The complement system is initiated.