Make sure the screws are tight or this will cause reduced sustain of the string. Use hard materials for the Bridge and Nut parts that are in contact with the string. For my own strat, I made a new Nut out of an old brass tap. This replaced the plastic one supplied with the guitar I bought in 1972. Lower the pickups to increase the distance between the pole pieces and strings.
Some people raise the pickups to produce maximum drive to the amplifier.
Unfortunately, pole pieces are magnetic, and close proximity to strings will dampen their vibration. Use a high output pickup. Seymour Duncan have a strat single coil replacement that is very resonant. Easy to get feedback just above middle pitches but at the expense of losing the high 'top' you expect from strat's. When an amplifier overloads it clips the signal, high overload simply causes the output waveform to eventually switch between two voltage levels of a value determined by the internal power supplies.