The remyelinization process occurs slowly, with function returning in a proximal to distal pattern. There can be four different presentations Ascending GBS- Most common presentation. Usually no loss. Clinical presentation- Recent history of viral infection, some may have recently received vaccination. GBS is characterized by muscle weakness and areflexia.
Symptoms tend to be symmetrical and ascending from legs to trunk and arms.
Respiratory failure is attributed to mechanical failure and fatigue of intercostals and diaphragm. GBS does not affect level of consciousness, cognitive function or pupillary signs. Diagnosis is based on clinical picture. Insidious onset, unilateral, unknown etiology. Clinical Presentation- Symptoms develop slowly, so years may pass before a diagnosis is established.