A strong case is made that burn centers are adept in all the facets of wound care, line management, nutrition, and prevention of pulmonary complications that these immunosuppressed patients require. Nov 4 2000. The role of drug metabolism and reactive metabolites that cause serious cutaneous and systemic reactions is the focus of this excellent review. Lyon, Calum C. Carmichael, Andrew J. Toxic epidermal necrolysis and paraneoplastic pemphigus. The need to consider paraneoplastic pemphigus in the differential diagnosis of TEN is illustrated well by this case report.
Skin biopsy is considered essential in establishing the correct diagnosis.
Incidence and etiology of Stevens-Johnson syndrome and toxic epidermal necrolysis in AIDS patients. Journal of Investigative Dermatology. The pathophysiology of this increased risk is considered, with roles for co-medication as well as depletion of metabolic substrates. Archives of Dermatology. July 1997 Apoptotic keratinocytes are described by the authors as occuring in several skin diseases, but most specifically in erythema multiforme and Stevens-Johnson syndrome.