After t 2 the number of cells that are X m is recorded for each of the m replicates and thus we obtain the distribution of blood cells that are maternally inactivated in m individuals. I believe that the estimates of the initial number of HCS precursor pool n 0 are unreliable. I believe that a 5 th stage should added to the program at which a sample from the s 1 blood cells is taken by the researcher to examine inactivation patterns. Possible scenarios of how skewed XCI can arise and how these can be simulated. Variable Clonal hematopoiesis Change the initial assignment of XCI states from random to that of your choice in the input.
X m is relative.
If the same seed for the random number generator is entered in the program, the same results will be in the output.