Postoperative chemotherapy and delayed radiation in children less than three years of age with malignant brain tumors. Carboplatin and vincristine for recurrent and newly diagnosed low-grade gliomas of childhood. The usual treatment of children with diffuse, intrinsic brain stem glioma is radiation therapy to the involved area. Ongoing studies are evaluating the efficacy of various radiosensitizers as a means for enhancing the therapeutic effect of this modality. To date neither adjuvant or neoadjuvant chemotherapy nor immunotherapy when added to radiation therapy has been demonstrated to improve survival for children with diffuse intrinsic tumors.
Studies using chemotherapy with radiation are ongoing.
Patients with extensive resection may be observed prior to the initiation of further therapy, preferably as part of a prospective clinical study. I and brain stem gliomas may have a different prognosis than other patients who have intrinsic lesions. A report of the Children's Cancer Study Group. Postoperative chemotherapy and delayed radiation in children less than three years of age with malignant brain tumors. Vandertop WP, Hoffman HJ, Drake JM, et al.