A. Inhibits topoisomerase II, an enzyme which cleaves both strands of double helical DNA, allowing passage of part of the intact double strand through the resulting gap. B. Inhibits topoisomease I, an enzyme which cuts one of the two strands of double helical DNA, allowing the other strand to swivel which allows DNA unwinding to occur. C. Inhibits the depolymerization of microtubules. D. None of the above. D. All of the above.
Tamoxifen is a nonsteroidal agent that has shown potent antiestrogenic properties.
For the palliative treatment of advanced breast cancer in postmenopausal women. For the palliative treatment of advanced prostate cancer in men. D. None of the above is correct. B. Other tubulin interactive agents like vinblastine and taxol. C. Other DNA-interactive drugs like cyclophosphamide and mechlorethamine D. None of the above.