Abnormal reflexes may be present. There may be an increase in the deep tendon reflexes. The goals of treatment are to cure the infection and to reduce progression of the disorder. Treatment of the infection reduces new nerve damage and may reduce symptoms but does not cure existing nerve damage. This is then followed by benzathine penicillin, 2.4 million units IM once a week for 3 weeks.
Symptomatic treatment is required for existing neurologic damage.
Rehabilitation, physical therapy, occupational therapy, or other interventions may be appropriate for people with muscle weakness . Analgesics may be required to control pain. Progressive disability is possible if the disorder is left untreated. People with late syphilis infections are at greater risk for other infections and diseases. Call your health care provider if loss of coordination , loss of muscle strength, or loss of sensation occurs, particularly if there is a known history of syphilis infection.