Of importance, Brachyury is involved in the morphogenetic switch that permits archenteron invagination. Current efforts are examining the mechanism of these signals and other molecular events that contribute to germ layer specification. We dissect neural tubes of mice as they form. Current analysis examines the detailed molecular adhesion transitions that assist in the folding of the neural tube. The normal morphogenesis is being compared to several mutants with a high penetrance of neural tube defects.
Trainees participate in every aspect of the study.
When they rotate in the lab they have the choice of topic. If they select my lab for research, topic choice is theirs. Through journal clubs, seminars, and discussions of the research, trainees acquire the knowledge and experience necessary for an independent career. See a picture of Dr. McClay's research in our Gallery . Site credits and contacts.