Diazoaminobenzene was recommended by the National Institute of Environmental Health Sciences for toxicological testing based on the potential for worker exposure and the lack of adequate toxicological data. Several structural analogs of Diazoaminobenzene are carcinogenic, suggesting the possible carcinogenicity of Diazoaminobenzene, as well. It is mutagenic in Salmonella. Published carcinogenicity studies in mice are considered inadequate and none have been conducted in rats. Plans are underway to develop protocols for toxicity and carcinogenicity studies.
Plans are underway to develop protocols for toxicity and carcinogenicity studies.
NMF was nominated only for genotoxicity testing and was found to be negative in the salmonella assay. Formamide was nominated by the NCI for carcinogenicity testing. The limited information available on formamide indicates that it is metabolized to formate. Since rodents metabolize formate much more efficiently than primates, they may be insensitive to formamide toxicity. Therefore comparative metabolism of formamide will be evaluated in rat, mouse, and human liver slices studies prior to any pre-chronic studies.