The women must be between ages 18-40. Metformin 500mg 3 times daily. Check a fasting blood sugar at least once. If P4 indicates ovulation, check HCG and P4 if no menses by 12 days after elevated P4. If not pregnant, check weekly P4 levels again beginning about day 20-25 of next cycle.
Patients are to keep menstrual calendars with all bleeding days and days of intercourse recorded.
This protocol will change over time as we get more experience with metformin and ovulation induction.