Beta-blockers have also been reported to lower natural CoQ10 levels. CoQ10 is generally well-tolerated. Nausea has been noted and other gastric disturbances may occur, such as diarrhea or loss of appetite. Insomnia has been reported with higher dosages. Adults with heart failure may take 50-200mg daily with a fatty meal to maximize absorption.
Potency can vary substantially from manufacturer to manufacturer.
CoQ10 appears to have increased bioavailability if taken with fats. Oil-based soft gel capsules may have a higher oral bioavailability than tablets or capsules produced from dry powder. Before and after the treatment period, a right heart catheterization was done, including a 3 minute exercise test. These results suggest improvement in left ventricle performance. Patients with congestive heart failure may benefit from additional treatment with CoQ10.