If further studies indicate that cells obtained in this fashion are useful in our research, a reduction in the amount of fetal tissue from elective abortions needed for the research is possible. Howard E. Gendelman, M.D. Only a handful of institutions in the world have ever been able to successfully isolate cells from rapid autopsies, he said. The first procedure, which was performed several weeks ago at Nebraska Health System University Hospital, allowed the scientists to obtain astrocytes and microglia, two of the three cell types UNMC is using in its research. However, Dr. Gendelman said new technologies are being developed which hold potential in this area. Astrocytes and microglia are the support cells for neurons and constitute the brain tissue.
Neurons are the most critical cells for brain function.
They work to receive and send out electrical signals throughout the body and are instrumental for normal thinking and motor function. Although pleased with the early success of the rapid autopsy program, Dr. Gendelman said much more work needs to be done. Determining exactly how many rapid autopsies would be required to give the UNMC research team the cells they require. There is limited scientific evidence that miscarriages, tubal pregnancies and stillbirths would yield the cells we need, so we are going to focus our resources on rapid autopsies for the immediate future. These expenditures include the purchase of a microscope that is now being used as well as the hiring of support personnel to help meet the increased workload resulting from the use of alternative sources.