Progesterone works to stimulate bone production, even when estrogen activity is low or absent.
Estrogen helps to slow bone loss, but progesterone is proactive through its stimulatory effect on the osteoblasts and thus directly encourages bone build-up. Synthetic progestins diminish the supply of natural progesterone, which further accelerates the osteoporotic changes within the bone. A and E cream for atrophic vaginitis is much safer that the synthetic estrogen creams so frequently prescribed by many medical doctors. Of much greater concern, however, is the fact that Premarin consists of estrone and estradiol, which have been shown to be carcinogenic. Fortunately, there are companies who make the natural progesterone cream that works wonders for vaginal dryness and many other conditions.