It is in a class of drugs known as phenothiazine neuroleptics. Taking lithium medication at the same time as phenothiazine drugs might increase the risk of nerve damage resulting in delirium and seizures. Until more information is available, people taking perphenazine should exercise caution when supplementing with products that contain lithium. Coenzyme Q10 Phenothiazine drugs similar to perphenazine can cause changes in heart activity in some people, which might be prevented by supplementing with coenzyme Q10. Therefore, some health practitioners may recommend coenzyme Q10 supplementation to people taking perphenazine.
Vitamin C Taking phenothiazine drugs can stop menstruation in some women.
Two women taking phenothiazines similar to perphenazine began menstruating following supplementation with 6 grams of vitamin C each day. 5 Controlled studies are needed to determine whether vitamin C supplementation might benefit women specifically taking perphenazine who are experiencing menstrual changes. Until more information is available, some health practitioners might recommend vitamin C supplementation to women who stop menstruating while taking perphenazine. Vitamin C might also enhance the effectiveness of neuroleptic drugs such as perphenazine in the treatment of schizophrenia . One uncontrolled study showed that 10 of 13 individuals experienced a reduction in disorganized thoughts, hallucinations, and suspicious thoughts when 8 grams of vitamin C was added to their daily drug therapy.