If humanity had obeyed God, nature would have obeyed humanity. To understand the tragedy, consider the power of a policeman. While he is submitted to his superiors, people obey him. But if he rebelled he would be ejected from the police force and people would then ignore his orders. To make people obey he would have to resort to violence.
People kill grubs, flies, weeds and so on.
Like an abused child, nature writhes in agony at the hands of its sinful overlords. If its oppressors are out of control, little wonder that nature is often out of control. Although individuals can, through Christ, restore the shattered union with the Lord of creation, God in his loving patience still allows people to reject him and so nature s woes continue. Then unhappiness will vanish, along with everyone opposed to Christ s rule. Though renowned for his humility, he professed to be humanity s only hope.