It is not active against vegetative forms of E.hystolitica and is thus not effective in acute intestinal amoebiasis. Orally administered diloxanide furoate is hydrolysed by intestinal esterases and absorbed as diloxanide, which is excreted mainly in urine. Occasionally - nausea, vomiting, diarrhoea, pruritus and urticaria. A course may be repeated if necessary. Available from the company on request.
Minimal absorption occurs after inhaled use.
Saline solutions should not be used for reconstitution as they cause precipitation. The recommended diluent is Water for Injection. Co-trimoxazole has been found more effective as prophylaxis against P. carinii pneumonia in AIDS patients. A specific parenteral preparation is not currently available. As for trypanosomiasis.