One cannot foresee the future, so one must look at the present. Since 'nothing is certain, nothing is impossible' you are free and nobody belongs to you. I was sent here for a reason I have not yet been able to fathom. I have no money, no resources, no hope. The first responsibility is to take care of oneself, so as not to be a burden to others.
Progress is made by adapting to one's own nature.
Rabelais treats this in a very positive light. The implication is not to seek after some ideal far removed from your own needs. You have no involuntary obligations. Discover your real needs, fulfil them, and rejoice in so doing. In this approach people make their own choices, and are responsible for the consequences.