It works on all kinds of depression including endogenous, and it works fast - within 4 days for most people. Response time varies from 1 day to 5 weeks. SAMe single-handedly normalizes liver function. Alzheimer's patients have severely depressed levels of SAMe in their brain. SAMe is possibly the safest and most effective substance yet discovered for arthritis, especially osteoarthritis.
SAMe stimulates cartilage growth and reverses the underlying cause of arthritis .
It also stimulates bone growth, important for arthritis and osteoporosis. SAMe also relieved the suffering of fibromyalgia patients in one study. It has also been mentioned in connection with migraines. The suggested dose is 200 mg 4 times daily or 400 mg twice daily. Do not combine SAMe with other antidepressants without consulting your doctor.