An elevation of liver enzymes occur in some patients. Most will recover completely, but 3 per 10,000 may die. We emphasis that these liver problems do not occur with the powder or ointment or any other benzo-pyrones . These may be substituted for the tablets if one uses 5 ml per day of the ointment or 10 ml per day of the powder. Since these amounts are rather large, we suggest applying half of them twice a day.
Many countries permit the importation of drugs for personal use.
The F.D.A. has now authorised it for clinical trial use. Capsules contain Melilotus extract, standardized to 5 mg of coumarin, with 25 mg of rutin. Some find the bioflavonoids upset their stomachs, so we advise patients to start with smaller doses and work up. We also advise them to split the dose up into halves. Double this may work better.