In addition, pulmonary hypertension may worsen considerably when NO is discontinued after as little as 24 hours of inhalat ion.
Researchers are only beg inning to understand how and why NO w orks.
Known to be a potent oxidant that can damage the lung, NO appears to work through increasing concentrations of a messenger molecule called cyclic GMP in the smooth muscle cell. His research program is funded by the National Institutes of Health, and his specific interests include regulation of nitric oxide synthase activity in neuronal cells and pulmonary vasular endothelial cells. Robert Dettman, PhD , received his PhD from Indiana University and completed postdoctoral training at the University of California, San Francisco. He is a recent recipient of the Richard D. Rowe research award from the Society of Pediatric Research. His interests focus on determining vascular precursors in the developing heart.