By measuring one or more of the subsystems, one can gain information and update the state estimate for the remaining subsystems with the quantum version of the Bayes rule. Using this rule. This triggers phagocytosis and elimination of RBCs from the circulation by splenic macrophages. We show here that clearance and phagocytosis of opsonized RBCs is also regulated by CD47-SIRP alpha. Sarcopenia is believed to play a major role in the pathogenesis of frailty and functional impairment that occurs with old age.
Progressive muscle wasting occurs with aging.
There is a disproportionate atrophy of type IIa muscle fibers with aging. There is also evidence of an age-related decrease in the synthesis rate of myosin heavy chain proteins, the major anabolic protein. Motor units innervating muscle decline with aging, and there is increased irregularity of muscle unit firing. The role of the physiologic anorexia of aging remains to be determined. Decreased physical activity with aging appears to be the key factor involved in producing sarcopenia.