In situations such as hemorrhagic shock, myocardial infarct, and organ transplantation, where tissue is rendered temporarily hypoxic, serious damage can occur upon reperfusion. Leukocytes contribute to this damage by adhering to vascular endothelium and releasing cytoxic substances.
Tetracyclines can inhibit the adherence and activation of leukocytes in vitro .
Postoperative pain can be a significant deterrent to dental treatment. We are interested in investigating new analgesic regimens that offer significant pain relief with minimal side effects. Doxycycline reduction of F-actin content of human neutrophils and fibroblasts. Protective effects of doxycycline in mesenteric ischemia and reperfusion. A comparison of two regimens for control of postoperative periodontal discomfort.