Rare instances of esophagitis and esophageal ulcerations have been reported in patients taking the tetracycline-class antibiotics in capsule and tablet form. Maculapapular and erythemataus rashes, exfoliative dermatitis has been reported but is uncommon. Fixed drug eruptions, including balanitis have been rarely reported.
Photosensitivity is discussed above.
Hemolytic anemia, thrombocytopenia, neutropenia and eosinophilia have been reported. Dizziness, tinnitus, and visual disturbances have been reported. Myasthenic syndrome has been reported rarely. No abnormalities of thyroid function studies are known to occur. Because the tetracyclines have been shown to depress plasma prothrombin activity, patients who are on anticoagulant therapy may require downward adjustment of their anticoagulant dosage.