Traditional synthetic strategies have typically produced 10-20 new candidate drug molecules per synthetic chemist per year. Combinatorial techniques aim to increase this number to 1000-2000 per year. However, utilization of this strategy for combinatorial product characterization would require increasing analytical staffs, instrumentation and space by 100 fold. MW information provides for characterization of each mixture component. An on-line UV detector provides purity information for each mixture component.
Networked information handling effectively handles large quantities of data.
Automation of sample preparation utilizes Zymark Master Lab, System 5 and Easy-Fill modules. Autosampler systems provide for unattended instrumental analysis. Productivity enhancement has been benchmarked at 18 times traditional approaches. Although small drug molecules and biomolecules differ significantly in structure, we have successfully applied many of our small molecule analysis strategies for biomolecule characterization. The system provides for complete automation of sample cleanup and analysis.