Animal bioassay data are frequently used to estimate risks to humans from environmental and occupational exposures.
Rodent liver is a common target organ in cancer bioassays.
EAF are adaptive in nature and EAF hepatocytes have an altered metabolism, which confers resistance to toxic effects of xenobiotics. Another characteristic is a high rate of cell replication and apoptosis in EAF hepatocytes. The major efforts of the section are to study the regulation of cell cycle control and apoptosis in EAF during chemical carcinogenesis. The primary aim of this research is to facilitate risk assessment and to reduce uncertainties associated with cancer risk assessment especially in extrapolating from animal species to humans and to low doses.