Bar S . These studies involve the use of several well-characterized clones of cultured human and bovine endothelial cells, model endothelial cell membranes, organ perfusion systems and intact animals. Joseph S . Dillon Joseph S . Dillon S .
Obesity is associated with hyperinsulinemia and increased islet cell insulin secretion.
This compensatory mechanism is lost with the onset of diabetes. The signal from adipose cells to b cells is unknown. Dr. Dillon is exploring the effects of adipose tissue secreted substances, such as leptin, TNF g and fatty acids, on insulin secretion and gene expression in the b cell. Ngozi E . Erondu Ngozi E .