Poorly differentiated or high grade tumors have pleomorphic cells, abundant mitoses and hyperchromic nuclei. They metastasize early. The cellularity of the tumor is generally in inverse proportion to the collagen production. Tumors are graded from 1 to 4 on cellularity, nuclear atypia and mitoses with high grades carrying a worse prognosis. Treatment of fibrosarcoma includes radical surgical excision and adjuvant radiation therapy.
Prognosis is largely dependent on the tumor grade.
Treatment and Prognosis , W.B. Saunders, Co., 1991.