Hunting skunks is not very popular. Many skunks are killed on the road every year, because they will not run away from a confrontation. They may try to spray the car, or are in the act of warning when they get hit. Sometimes, especially in residential areas, skunks become pests. They will go through a trashcan, and they may dig holes in someone's yard in search of food.
Skunks also carry rabies.
If you ever see a skunk in the day- time, beware. The disease could have disoriented the skunk, and it will abandon its usual habits. Skunks are not necessarily aggressive animals, so a failure to avoid confrontation is also an indicator that the skunk is sick. Some people keep skunks as pets. They are de-scented at four weeks of age, and have no other unpleasant qualities.