Don't use on sick or debilitated animals without veterinarian approval. Don't use in animals with liver or kidney disease. Drug and Food Interactions Don't use with laxatives as these reduce the time the drug is in contact with the parasite and reduces the effectiveness. Diarrhea will also decrease the time the medication is in contact with the parasites. No known food interactions.
Piperazine does have a wide margin of safety.
Contact your veterinarian or the Animal Poison Control Center if you think your pet may have accidentally received or been given an overdose of the medication. Special Note Roundworms, hookworms, and tapeworms are zoonotic, meaning they can infect humans. Multiple species carry the roundworm parasite including dogs, cats, raccoons, and pigs. These eggs contaminate the ground where the animal has defecated. Children who play in the area and don't wash their hands before eating or putting their hands in their mouth or who eat dirt contaminated with the eggs are most at risk of becoming infected.