Typical situations for women involve death of a parent. But, even death of a parent she did not completely care for can bring up issues. Often today's midlife women have done more than their share of tending to older parents, yet they grew up in families where their brothers were favored. This gap causes unresolved conflict that may bubble up at the parent's death. And any unresolved issues with parents can lead to this.
Unexpressed anger can turn towards the self and lead to depression.
Another common situation for women is death of a child through violence, suicide or accident.