When the couple shares DQ alpha antigens in common, the G molecule put on the placental cells by the father is too similar to the G molecule that the woman's father put on her placenta to sustain her in her mother's uterus. Consequences Inadequate blocking antibody formation. Ineffective camouflage of placenta.
Placental cells fail to grow and divide.
Death of placental cells. Message sent from father to stimulate blocking antibody. Please see A Consumer's Guide for Lymphocyte Immune Therapy for more information on paternal and donor lymphocyte immunization. Copyright 1998-2000 Finch University of Health Science, Chicago Medical School.