We are particulalry interested in the cross talk that occurs between the major signal transduction pathways. The basic information gained from these studies will allow us to understand more about diseases such as Cystic Fibrosis and Sjorgren's Syndrome. The role of cGMP and cADPR in muscarinic regulation of cAMP accumulation. Identification and regulation of the enzymes involved in cAMP synthesis and degradation. A second area of interest is in determining whether GTP-binding proteins located on secretory granule membranes play a direct role in the exocytotic process.
Regulated secretion requires proteins to confer membrane specificity and control fusion.
Recent evidence suggests that GTPgS stimulation of secretion occurs downstream from the G proteins that activate effector systems, and can be mimicked by smg peptides. Identification of muscarinic receptor subtypes in mouse parotid gland. The measurement of mandibular cortical bone height in osteoporotic vs. non-osteoporotic postmenopausal women. Biphasic effects of carbachol on isoproterenol-stimulated cAMP accumulation in mouse parotid acini.