When the inflammation is severe it spreads from one villus root to another and there is inflammation between them. Category 4 Patients Category 4 patients have both antiphospholipid antibodies and anti-DNA antibodies and show changes in the placenta characteristic of both. They also damage the decidual cells that the placenta attaches to. They can be counted and evaluated. These latter hormones are Serotonin, Endorphins and Enkaphlins.
Necrosis refers to death of a cell or tissue.
The culprits are the Natural Killer Cells mentioned above. In addition at the end of the pathology report the numbers of Natural Killer Cells in the placenta that are actively killing are counted. The treatment for this problem is preconception IVIg . These cells are of different types. They are called Monocytes, Lymphocytes, Plasma Cells, Granulocytes.