There may, however, be value in the results of in vitro testing for presumptive information. Even in the absence of controlled clinical trials, determination of MICs in broth can serve the clinician by excluding drugs with adverse side effects, to which the patient's isolate is definitely resistant. The rapid growing mycobacteria may cause human infections that are found most often in skin, soft tissue, or sternal wounds. Pulmonary, skeletal, and serious disseminated infections have been reported. M. marinum is predictably susceptible to rifampin and ethambutol.
Susceptibility results to other antibiotics vary, making laboratory testing necessary.
If an isolate is resistant in vitro , therapy of drug combinations including rifampin for M. kansasii infections is less successful and must be prolonged. These procedures do not use serial dilutions to provide quantitative MIC values. The patient's physician will be provided with MIC values for interpretation. Guthertz LS, et al. Quality control of individual components used in Middlebrook 7H10 medium for mycobacterial susceptibility testing.