Although maternal and neonatal morbidity and mortality has been decreasing over the last 2 decades, there are still some increased risks for both. With careful management, there is no reason that women with sickle syndromes cannot have children. All patients should receive accurate information at puberty and periodically throughout their reproductive lives about risks of pregnancy, genetic transmission of sickle syndromes, methods of contraception, prenatal diagnosis, prevention of sexually transmitted disease and the increased responsibility of raising children. Clinical Findings Subjective Data Present Illness . Patient usually present with amenorrhea and associated symptoms of breast enlargement and tenderness, morning sickness, change in pigmentation, fatigue, and quickening.
Menstrual irregularity is common in patients with sickle syndromes.
Past Medical History . Characterization of menstrual history and sexual activity is important. Occurrence, outcome, and management of previous pregnancies should be determined. Past episodes of sexually transmitted diseases is sought. Previous transfusions, occurrence of alloantibodies, and transfusion reactions are documented.