The plant matter can be infused into a tea, ground into a paste and rubbed topically onto the skin, smoked, or eaten. The physical effects include severe and often uncomfortable dizziness, parched mouth and throat, increase in heart pressure and heart rate, painful urination, etc. A student reported to me a long term negative effects on the eyes' ability to focus from one use of smoked leaves, reversing itself after 8 months. The effects can last anywhere from 12-48 hours after entering the bloodstream. Subjective effects include severe visual distortions and hallucinations, amnesia of the experience, and a complete break with reality during use.
Users are often quite violent.
It is hairy, has funnel shaped flowers whose sections taper to thorny, gangly points, and one heck of a stink. All in all, very much unlike a tomato. I don't believe the chemical causes any permanant physical problems, in and of itself. Of course, please note that the drug can cause death, which is a very serious permanant physical problem. Most emergency room cases or overdoses are due to the inconsistency of the drug between plant parts and between plants.