This product contains the antihistaminic agent diphenhydramine. Since the depressant effects of antihistamines are additive to those of other drugs affecting the CNS, patients should be cautioned against drinking alcoholic beverages or taking hypnotics, sedatives, psychotherapeutic agents or other drugs with CNS depressant effects during antihistamine therapy. Diphenhydramine has an atropine-like action which should be considered when prescribing this product. As this product contains pseudoephedrine, do not use in cases of high blood pressure, heart or thyroid disease, diabetes, prostatic hypertrophy, or glaucoma, except on the advice of a physician. Drowsiness, dizziness, dryness of the mouth, nausea, nervousness, palpitation and, rarely, allergic reactions may occur.
Paradoxical excitation is especially likely to occur in pediatric patients.
Single or repeated therapeutic doses of acetaminophen have no effect on the cardiovascular and respiratory systems. It was found not to produce gastric irritation, erosion or bleeding that may occur after salicylates administration. With regular use of acetaminophen, a slight increase in prothrombin time can occur in patients receiving oral anticoagulant treatments. However, clinical significance of this effect is not yet clear. With the majority of patients, symptoms of an overdose of acetaminophen high enough to cause hepatic toxicity will appear promptly.