All six children have died. One was a half-sister of the infant in Case 4. One is the other half-sister of the infant in Case 4. Eight are male. Of the nine mothers for whom information is available, seven are reported to be intravenous drug abusers.
None is Haitian.
The infants lacked the congenital anomalies associated with Di George's syndrome. The occurrence of immune deficiency in the infant in case 4 and in her half-sisters raises the possibility of an inherited disorder. However, inheritance would have to have occurred in a dominant manner, an inheritance pattern not previously described for immunodeficiency resembling that seen in these half-sisters. Case 2 had essentially normal T-cell responses to mitogens in vitro. Cases 2-4 were less than 6 months old when they had serious opportunistic infections.