The list of indications has expanded to include many conditions. It is reported that in inflammatory diseases of the bowel, Ozone promotes healing and restores the floral balance distrubed by harmful germs. In a typical treatment, daily insufflations are applied starting with 50 ml and increasing as tolerated in increments until 500 ml are administered. Although the above techniques of ozone administration represent the majority of hospital or office based procedures, others deserve mention. Listed indications include asthma, acne, some allergic conditions and some cases of arthritis.
Ozone is approximately ten times more soluble in water than oxygen.
It may be rinsed orally in conditions such as thrush and periodontal disease, swallowed in cases of gastritis or stomach cancer, or irrigated in chronic bladder inflammation. Ozonated olive oil provides long term, low dose exposure of Ozone to tissues, and it may be used topically or consumed by drinking small amounts of used on salads. For the reason that below 0.30 ppm the probability of Ozone traversing the respiratory epithelium and entering the systemic circulation is so low, very few studies have attempted to measure these effects. The techniqe of major autohemotherapy and others that involve the direct introduction of Ozone in the circulation, shows that Ozone exposure increases metabolic activity of red blood cells. Although the inhibition and lethal effects of Ozone on disease producing organisms have been observed since the latter part of the nineteen century, these actions have not yet been completely explained.