Patients should be warned to keep Nicorette Plus out of the reach of children and pets. Simultaneous smoking and chewing of Nicorette Plus should be avoided. In patients with certain cardiovascular and endocrine diseases, the risks of using nicotine should be carefully weighed against the benefits of including Nicorette Plus in a smoking cessation program. Cigarette smoking is felt to play a perpetuating role in hypertension and peptic ulcer disease. Women of childbearing age should be advised to take adequate precautions to avoid becoming pregnant while using Nicorette Plus.
Nicotine passes freely into the breast milk.
Nicorette Plus should be used with caution in patients with oral or pharyngeal inflammation and in patients with a history of esophagitis or peptic ulcer. The Nicorette Plus dosage form dictates that it be used with caution in patients whose dental problems might be exacerbated by chewing gum. In such patients, prior dental evaluation may be advisable. Nicorette Plus is sugar-free and has been formulated to minimize stickiness. As with other gums, however, the degree to which Nicorette Plus may stick to dentures, dental caps or partial dentures may depend on the materials from which they are made and other factors such as amount of saliva produced, possible interaction with denture adhesives, denture cleaning compounds, dryness of mouth due to other causes and salivary constituents.