More interesting was the Delaware use of hops as a sedative, drinking hop tea several times a day to alleviate nervousness. Cherokee, Mohegan, and Fox also used the plant as a sedative. George III is said to have slept on a pillow stuffed with hops to alleviate some symptoms of his porphyria. Toxicity Hops dermatitis has long been recognized. Not only hands and face, but legs have suffered purpuric eruptions due to hop picking.
Many varieties are available.
Morphological studies indicate that Japanese, European and American plants may be characterized by their hairy behavior at node part of stem. Varieties may also be classified into early, midseason, and late. Some triploid varieties grown in Europe are seedless. Resin content is controlled by many pairs of genes. Disease resistance is found in some tetraploids.