I would like to take SAMe for depression. The drug works by blocking the effects of the hormone estrogen on breast cancer cells but acts like estrogen elsewhere in the body, and may also have some positive side effects such as lowering cholesterol and slowing the bone loss associated with osteoporosis later in life. A number of studies suggest that SAMe works as well as antidepressant drugs to counter depression. Even better, it often takes effect within a week, while antidepressants can take up to a month to kick in. But like antidepressants, SAMe doesn't work for everyone.
SAMe is unlikely to interfere with the effectiveness of tamoxifen.
Pharmacist Kathy Grant, a colleague at the University of Arizona, tells me that while SAMe functions almost everywhere in the body, it doesn't seem to affect sex hormones or their receptors, the targets of the tamoxifen you're taking. For this reason, I see no reason why you shouldn't try SAMe. You should be aware that there are still questions about whether SAMe is absorbed by the body when taken orally. If you try SAMe, be sure to take it on an empty stomach. Buy the least expensive product you can find.