Once absorbed, the penicillinase-resistant penicillins bind to serum protein, mainly albumin. The penicillinase-resistant penicillins vary in the extent to which they are distributed in the body fluids . With normal doses, insignificant concentrations are found in the cerebrospinal fluid and aqueous humor. All the drugs in this class are found in therapeutic concentrations in the pleural, bile and amniotic fluids. The elimination half-life for dicloxacillin is about 0.7 hour.
Nonrenal elimination includes hepatic inactivation and excretion in bile.