Usually see thick course white epithelium with punctuation, mosaic patterns and vascular congestion. Neovascularity suggests early invasion. BiChloro Acetic acid, TriChloro Acetic acid. Repeat every three weeks until clear. Need 3mm margin to decrease recurrence.
Recurrences usually occur in untreated areas.
Furthermore, since in situ disease is commonly multifocal and invasive cancer is usually unifocal, it seems unlikely that many foci will regress to leave only one area of invasive disease. Thus, the frequency with which in situ vulvar neoplasia will progress to invasive cancer is unknown, but certainly does not compare with similar lesions of the cervix.