Estrogen taken alone, called unopposed estrogen, caused a high rate of endometrial hyperplasia. Topical natural progesterone products have not been well studied although they are commonly used to treat a variety of conditions. These include premenstrual syndrome, anovulatory cycles, dysfunctional uterine bleeding, endometriosis, uterine fibroids, heavy menstrual bleeding and menopausal symptoms. He asserts that his study showed a reduction in fracture rate, an increase in bone density, and the safety of using natural progesterone. This point of view is controversial in the prevention of osteoporosis.
Wild yam is used in tincture form, topical creams and gels, capsules, teas, tablets, and sublingual.
Its therapeutic value was stated earlier but is currently in common use for the treatment of PMS, uterine cramps, abdominal colic, and menstrual irregularity.