Case reports show delayed absorption, causing levels to peak as late as 72 hours. Mild ingestions present with vomiting, drowsiness, ataxia, slurred speech, nystagmus, dystonic reactions, and hallucinations. Severe intoxications may produce coma, seizures, respiratory depression, and hypotension. Hyperthermia may be seen as a part of neuroleptic malignant syndrome. Neurologic effects Ataxia, slurred speech, nystagmus, dystonia and other extrapyramidal movements, and various degrees of central nervous system depression are common.
Seizures are common in children with epileptic disorder.
In severe cases coma, seizures may be seen. Neuroleptic malignant syndrome and transient ophthalmoplegia also are associated with carbamazepine overdose. Respiratory effects Respiratory depression or apnea requiring mechanical ventilation may be seen within first 24 hours of presentation. Pulmonary edema or aspiration pneumonia may occur. Cardiovascular effects Cardiovascular effects are rarely seen in children.