3' NTR makes strand initiation and is not poly-adenylated. RNA replication machinery cleaves specific proteins. NS5B - membranes associated for RNA replication. Infected cell death. Infecting genotype may influence pathogenesis, sensitivity to therapeutics.
Rapid evolution leads to immune escape and persistence as well as therapy-resistant variants.
Combination therapy is the most effective for treatment. Multivalent vaccine is probably required for global protection. Highly conserved, basic. Nuclear localized forms. Anchorage independent growth.