No fetal effects at rates below NOEL for adults. No reproductive effects were noted. Rotenone did not induce gene mutations in bacteria or yeast, but it increased the frequency of gene mutations in mouse lymphoma cell in vitro without met.bolic activation. No mutations were induced in mice in vivo by rotenone. No chromosomal effects were observed in rats or mice treated with rotenone, and yeast treated with rotenone did not show increased mitotic recombination or mitotic gene conversion.
Rotenone is an inhibitor of oxidative phosphorylation.
Currently, use of rotenone or derris or cube roots on growing crops is exempt from the requirement of tolerances, and neither tolerances nor exemptions exist for rotenone residues in animal commodities. Cranberry and piscicide uses are classified for restricted use. Users must consult their State Fish and Game Agency before applying rotenone products. Because of significant data gaps on the effects of rotenone in upland game birds, waterfowl, estuarine and marine organisms, a statement is required on all end-use products giving directions for use for killing fish. The statement requires mandatory consultation with state or federal fish and wildlife agencies and will minimize effects on non-target organisms.