WinNonlin Enterprise has a new tool in the toolbox, Deconvolution. The most common application of the deconvolution drug model is in the evaluation of drug release and drug absorption from orally administered drug formulations. For these types of problems, the measured concentration data is the convolution of the absorption rate with the unit impulse response function, and the user is interested in determining the absorption rate. Deconvolution is available in WinNonlin as a command on the Tools menu. It is also fully accessible via scripting.
Plots remain an output option, displayed in the chart window.
When a user selects Transpose Final Parameters, the Secondary Parameters are now automatically transposed as well. The results from version 3.1 will match the Type III results from version 3.0. The default method is for the chart legend to display only the group variable value. An option provided in the Chart Wizard, Use group headers, changes the way that those variables are displayed. It has the ability to guess whether the file has headers in the first row and what the delimiter for the file is.