This article highlights some of what we've learned so far about this important emerging area of research. It also provides some basic guidelines on things to consider if and when you face these decisions. One consideration is whether to switch to a regimen without a protease inhibitor. Another reason for switching drugs in a regimen is to lower cholesterol and triglyceride levels. However, there's conflicting information on whether switching helps reverse the fat redistribution in people with lipodystrophy.
People also consider switching therapies because of side effects or treatment fatigue.
In either case, it's important to talk with your doctor to determine if switching is the best option. For instance, side effects may subside over time or they may be managed in other ways. For treatment fatigue, switching to a regimen with fewer pills or one that's less demanding in terms of timing and food restrictions may be a viable option. Whatever the decision, talk with your doctor to jointly determine personal goals. Keep in mind that guidelines are important.