This proportion is in turn influenced by genetics and by the amount of certain substances in the diet, particularly cholesterol and saturated fat. Because the production of these lipoproteins is complex, several points can be targeted for action by various drugs. Decreased cholesterol formation results in a reduction in VLDLs and hence LDLs. These drugs also stimulate receptor-mediated clearance of LDLs.
Recent studies suggest a reduction in osteoporosis as a result of treatment with statin drugs.
This enzyme is an extracellular species present in the blood and gut. Effects on other lipase enzymes may account for the nausea common to this drug. Cholesterol production in the liver is reduced, probably as a secondary effect due to lower VLDL levels, while fecal cholesterol excretion is enhanced. Clofibrate is fairly toxic and may be carcinogenic. 6 oils Modifications in diet can alter blood fat and cholesterol levels significantly.