Young plants are thinned and kept shaded and protected from wind. As the plants grow shading is slowly removed. When approximately 9 inches they are transplanted to permanent fields. Young trees are planted 2 feet apart. The closeness offers wind protection and prevents undergrowth competition.
Organic fungicides keep branch canker in check.
In the 10th year, when quinine content is the highest, the trees are harvested. Trees may be partially stripped and bound with moss for protection. The moss also facilitates the growth of new bark. The replacement bark normally gives a higher yield of quinine. Barks from trunks, roots and branches are all used.