It is best to use birth control while being treated with methotrexate. Tell your doctor right away if you or your partner becomes pregnant. Do not breast feed during treatment. Tell doctors or dentists that you are being treated with methotrexate before you receive any treatment from them. It is more common with higher doses and may last for 24 hours.
Most people have little or no nausea.
Drink plenty of liquids. Eat often in small amounts. Your white blood cells will decrease 1-2 weeks after you start taking methotrexate. They will return to normal 2-3 weeks after your last dose. When they are low, you are at greater risk of having an infection.