Dosage works immediately. Must move to the small intestine before being absorbed into the bloodstream. After absorption, it passes through the liver, where much is biotransformed into other chemicals. Moves directly to the bloodstream through the lungs. Dosage can be adjusted.
Smoking allows patients to match usage to their symptoms, meaning smaller doses.
Psychoative side effects are greater with oral THC due to changes in the liver and the lack of other cannabinols which may serve as buffers. Psychoactive side effects are minimal due to patient control over dosage and the presence of other cannabinols which occur naturally in marijuana. Heavy psychoactive effects may create unpleasant reaction, especially in older patients. Lighter psychoactive side effects may benefit patients by producing mild euphoria and sense of well being. Natural marijuana contains other elements and natural compounds besides THC which work synergistically and offer unique therapeutic benefit Marinol and other similar medications are often not as effective as whole marijuana.