I. None will be histocompatible with parents. I. New haplotypes may arise due to rearrangement of genes. Peptide derived from endogenous intracellular proteins. Binding cleft is closed end. Peptide are derived from exogenous proteins Binds to peptide of 13-18 amino acid residues.
Peptide binding cleft is open end.
Generally encode a chain and b microglobulin. Expressed as low concentration and less polymorphic. However several b chains are encoded by these regions. Class-I MHC Expressed by all nucleated cells. Heterozygous animals express both maternal and paternal haplotypes.