Readily treated with intravenous fluids and trendelenburg position. Bradycardia results from vagal stimulation. This is a rare problem if medicine administered in increments with BP monitoring. Therefore, important to monitor rate. Miscellaneous Effects -Can cause significant nausea and vomiting even in small doses.
Metabolism is much slower, so can accumulate.
Depth of respiration decreased as opposed to rate as seen with narcotics. All with rapid onset IV with sedation in 3 - 5 minutes. Onset of lack of recall delayed 20 - 30 minutes. Potentiates respiratory depression of narcotics. In sedative doses can produce mild respiratory depression with decrease in tidal volume with small increase in rate.