The roots and bark of these plants also have medicinal uses. A comb-like wooden tool was used historically for harvesting the berries. The fleshy fruit of this understory tree ripens in September and October but is best harvested only after the first frost. Pawpaw bark fiber was used by the Menominee and Potawatomie for weaving bags. Grape vines prefer dry, sandy, mediacid soil.
Some species prefer the open, others more shaded areas.
Grape fruits are eaten fresh or dried. The stems were used for cordage and sap from the plant was used as a beverage. Tea made from grape twigs was used for medicine. Plum fruits were eaten fresh or dried. Sometimes the dried fruit was powdered and used as an ingredient in stews.