In addition the electronegativity of the fluorine group will also change the electron density of the molecule. These changes, at active or inactive sites of a molecule will influence the receptor binding and the drug's properties. This can often be accomplished with reagents other than elemental fluorine or hydrogen fluoride. My experience with selective fluorination, by fluorine sources other than hydrogen fluoride or elemental fluorine, can be used to create these new chemical entities. Top Patent Strategies Intellectual property is a critical issue today.
Patent protection needs to be as broad as possible and defended by the patent holder.
I have worked with patent counsel to provide the broadest coverage possible on patent applications and have helped patent counsel successfully defend these positions against the patent examiner's repeated rejections. In the course of my career I have had opportunity to attend many different symposiums and write papers on a variety of topics. For a complete list, click here .