The biological information in genomic DNA is not intelligible on primary sequence level. Therefore, functional interpretation of the raw sequence data is a prerequisite for any kind of sequence-based functional genomics .
Transcription absolutely requires anchorage of genomic DNA to the nuclear matrix.
Anchoring of regulatory elements like promoters and enhancers to the nuclear matrix. Ensuring long term activity of promoters and enhancers in chromatin. Insulation , rendering a functional domain insensitive to position effects. Genomatix is conducting a research project to define and detect MARs by computer-analysis. LCRs act to open up a chromatin domain which is necessary for active transcription and sometimes act as enhancers of transcription themselves.