Although it has more side effects than more recent drugs, it is still very beneficial and more effective than conventional neuroleptics in reducing symptoms, including those resistant to the older drugs. The drug reduces aggressive behavior and suicidal impulses and may even improve negative symptoms. The effects on symptoms may not be evident for up to nine months, however. It is particularly useful in younger people, although side effects are common, and newer atypical drugs may prove to be better choices. There are some serious side effects, including seizures, blood abnormalities, and injury to heart muscle.
Older women are at higher risk, and it can be reversed if the drug is withdrawn at once.
Of additional concern are a few reports of sudden death from heart muscle injury associated with initial usage of the drug. The drug appears to increase triglyceride levels. People taking clozapine should have both triglyceride and blood glucose levels monitored frequently, especially in people with or at risk for diabetes. Like clozapine, risperidone may have a beneficial effect on negative symptoms as well as psychosis. Risperidone may also improve verbal memory and the quality of sleep.