Failure to properly regulate apoptosis can have catastrophic consequences. Excessive estrogens can cause fluid retention, weight gain, migraines and over stimulation of the breasts, ovaries and uterus, leading to cancer, endometriosis, polycystic ovaries, uterine fibroid tumors . Insufficient estrogen levels or fluctuations of estrogen can lead to hot flushes, vaginal dryness, rapid skin aging, urinary problems, excessive bone loss and possible acceleration of dementia. An excess of estrogen, relative to testosterone, is thought to play a role in the development of prostate problems in men. Most scientists now agree that by-products of estrogen metabolism are the cause of breast cancer , ovarian cancer and prostate cancer .
Progesterone is a hormonal balancer, particularly of estrogens.
It enhances the beneficial effect of estrogens while preventing the problems associated with estrogen excess, which includes Polycystic Ovaries. Natural Progesterone also helps regulate apoptosis. Progesterone also helps create a balance of all other steroids. It also has intrinsic calming and diuretic properties. It is important in women, but it's importance in men for the maintenance of prostate health is only now being appreciated.