Most patients heal within four weeks.
Some patients may require an additional four weeks of therapy. Omeprazole delayed-release capsules, in combination with clarithromycin, are also indicated for the treatment of patients with H. pylori infection and active duodenal ulcer to eradicated H. pylori. In patients who fail therapy, susceptibility testing should be done. If resistance to clarithromycin is demonstrated or susceptibility testing is not possible, alternative antimicrobial therapy should be instituted. The efficacy of omeprazole used for longer than 8 weeks in these patients has not been established.