Patients with long-standing ulcerative colitis and sclerosing cholangitis occasionally develop cholangiocarcinoma. Hepatoblastoma is a common cancer in infants. It occasionally presents with precocious puberty caused by ectopic gonadotropin production, but it is usually detected because of failing systemic health and a right upper quadrant mass. The rare angiosarcoma has attracted attention because of an association with industrial exposure to vinyl chloride. Diagnosis of these tumors is based on histology.
Therapy is usually of little value, and the prognosis is poor.
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