Changes most pronounced in frontal lobes and hippocampus. Mania Elevated and euphoric mood. Bipolar disorder Cycling depression and mania. Norepinephrine - mainly produced by raphe nuclei in brain stem. Serotonin - mainly produced by locus ceruleus in brain stem.
Trycyclic antidepressants relieve depression by blocking reuptake of monoamines.
All of the above contribute to the biochemical basis of depression. Lithium - a form of salt which serves to normalize mania and depression in bipolar disorders. Alters the sodium and potassium levels within the body. Also affects brain catecholamines by increasing reuptake of norepinephine. Little know as to the neurochemical basis.