For example, models may differ with respect to the dependence of substitution rate on effective population size. This is an area of great interest and expertise in the Wakeley lab , and I am just coming up to speed. I am particularly interested in the effect of population structure on fixation probabilities in the presence of selection. My interest in this question is oriented toward microbial populations, for which estimates of effective population size are often many orders of magnitude smaller than estimates of actual population size. Population structure is often invoked to explain this observation.
Physical limits are one consideration.
Enzymes, for example, cannot do much better that the diffusion limit. Publications Most of my publications are listed in Medline and can be viewed here . Before starting here in April of 2001, I was a postdoc at the University of Utah in the Department of Biology .