Recent evidence from our laboratory indicates that the depletion of tissue glutathione levels fundamentally changes the nature of inflammatory gene expression in mice challenged with either bacterial endotoxin or live Gram-negative bacteria. Moreover, infection progressively depletes glutathione levels within certain tissues by a process that is independent of nitric oxide production. It is the ultimate objective of this research to define the relations that exist between cellular redox status and host responses to infection as a means of developing novel strategies for promoting protective responses and reducing host tissue damage. M.J. Parmely and S.W. Russell. Parmely, M.J .
Mononuclear phagocytes can utilize plasminogen activator to regulate human interferon- g .
Parmely, M.J ., W-W. Zhou, C. Edwards, D. Borcherding, R. Silverstein and D.C. Morrison. 1993. Adenosine and a related carbocyclic nucleoside analog selectively inhibit TNF- a production and protect mice against endotoxin challenge. Duval-Jobe, C., M. Leeson, A. Rawitch and M.J. Parmely . Regulation of plasminogen activation by human U937 promonocytic cells. Parmely, M.J. , S.-Y. Hao, D.C. Morrison, and J.L. Pace. 1995.