There is an oral lesion known as peripheral giant cell granuloma or giant cell epulis that is thought to represent a reparative or reactive process.
Ossification can be present, and such lesions can, uncommonly, recur.
Such lesions have a prominent fibrovascular background containing giant cells, occasionally of osteoclastic type. The most dense collagen bundles are formed in the base of the lesion, and these collagen bundles arborize above the base. It is near the base that the ossification occurs. Cellular fibrovascular areas that contain numerous giant cells are between the collagen bundles above this zone, and the lesion becomes less cellular towards the periphery. In this particular case, the surface is eroded and lined by ordinary granulation tissue.