Timentin should only be used during pregnancy if the anticipated benefit to the mother justifies the potential risk to the fetus. Penicillins have been shown to be excreted in human breast milk. It is not known whether clavulanic acid is excreted in breast milk. Nursing should be avoided during treatment with Timentin. Timentin should not be mixed with an aminoglycoside in the same container.
Penicillins can cause substantial inactivation of aminoglycosides.
Probenecid interferes with the renal tubular secretion of ticarcillin, thereby increasing serum concentrations and prolonging serum half-life of the antibiotic. However, probenecid has no effect on the renal clearance or serum concentrations of clavulanic acid. The presence of clavulanic acid in Timentin may cause a non-specific binding of IgG and albumin by red cell membranes leading to a false positive Coombs test. Prolongation of prothrombin time and bleeding time. Reduction in serum potassium and uric acid.