Embedded in the sclerotic tissue were remains of schistosome eggs. On right is a liver section from an experimental infection showing the initial granulomatous response to schistosome eggs which can progress to portal fibrosis. Bugs Database the fibrotic reaction to schistosome eggs in the hepatic portal circulation is the probable cause of obstructured portal circulation and portal hypertension. Because adult S. mansoni deposits eggs in veinules surrounding the gut, portal cirrhosis and hypertension are uncommon manifestations of schistosome infection. Hepatosplenomegaly is a common sign of S. mansoni infection.
Portal hypertension is the probable cause of the esophageal varices.
The intact liver parenchymal cells and normal liver function tests are usual in hepatosplenic schistosomiasis. In considering the treatment of this patient, which of the following statements is NOT applicable. There is an effective drug and the prognosis is excellent. Antihelminth drug treatment is necessary to stop egg production and progressive disease. With complete eradication of infection, the esophageal varices and other sequelae would quickly regress.