The locus ceruleus, located in the 4th ventricle of the brain, with its numerous connecting pathways to the rest of the brain, is thought to be an important mediating center. Also to be ruled out are hyperthyroidism and pheochromocytoma. Skin rash, nausea, headache, impaired sexual function and vertigo. Also, drowsiness and ataxia. There are reports of paradoxical effects such as increased levels of anxiety, psychotic episodes and suicidal impulses.
Withdrawal symptoms can occur after several months of use.
The Shen encompasses man's emotional and mental aspects. Through an adequate supply of Yin and Blood, the Heart houses the Shen. If these are deficient the Shen has no root and becomes Disturbed. The patterns of Blood Deficiency, Yin Deficiency or Disturbed Shen may cause anxiety. Conversely, anxiety can injure the Blood, Yin or Shen.