A calpain-10 gene polymorphism is associated with reduced muscle mRNA levels and insulin resistance. Genetic variation in the gene encoding calpain-10 is associated with type 2 diabetes mellitus.
Novel gene is linked to obesity, diabetes.
Altshuler, D., M. Daly, and L. Kruglyak. Guilt by association. Cox, N.J., et al . Duggirala, R., et al . Linkage of type 2 diabetes mellitus and of age at onset to a genetic location on chromosome 10q in Mexican Americans.