The key discriminating features are described below. Avoidance of things that cause excessive heat such as exercise, prolonged sun exposure and topical irritants is advisable. Potent topical corticosteroids may occasionally be effective in diminishing inflammation and may be useful in controlling itching. Menthol or pramoxine-containing lotions may also be helpful for itching. Oral corticosteroids, UVB exposure, PUVA, grenz radiation and methotrexate have all been reported to be effective be in severely resistant cases.
Some cases are refractory to virtually all forms of therapy, however.
Grover disease is unaffected by diet. These activities should be avoided. The goals of pharmacotherapy are to reduce morbidity and prevent complications. Retinoids - Decrease cohesiveness of abnormal hyperproliferative keratinocytes and may reduce potential for malignant degeneration. Effect keratinocyte differentiation.