In fact, a 14-day washout period should be used when transferring patients from one treatment to another. Seizures partially related to blood levels have been reported with the use of Wellbutrin. All doses should be given six hour apart, and no more than 150 mg should be given at one time. One advantage of Trazodone in the treatment of elderly patients is that no dosage alternation is required. In addition, its major metabolite also blocks alpha receptors and may account for the adverse reactions of dryness of the mouth and orthostatic hypotension.
Trazodone has strong sedative properties but little anticholinergic effect.
However, it may cause arrhythmias in patietns with prexisting cardaic disease. However, patients who have major depressive disorder with atypical features or those with a family history of a response to MAO inhibitors may benefit from these agents. Partial responders after treatment for 4-6 weeks should be on maximum doses without intolerable side effects before switching to another agent. Medication underdosing is the most common problem in the partially responsive patient. Non-responders on adequate doses for 6 weeks should be tried on a different class of antidepressants.