However, in contrast to HIV, three doses of a subunit vaccine provide good protection against the virus. This has resulted in some question as to the advisibility of mandatory vaccination of babies that are not at risk. The virus has a long incubation period and an insidious onset. Early symptoms include fever, malaise, and anorexia. Jaundice, dark urine, and pale stools follow.
Recovery is indicated by a decline of fever and renewed appetite.
Coinfection with HDV produces fulminant infection in both acutely and chronically infected individuals.