Pick the best seat for you in your class and then check on upgrades available at check-in. If you think you ll need them, grab a pillow and blanket as soon as you get on the plane, they go fast. Dress in layers so you can peel off or add to as necessary. Take a bathroom break, even if it s just to get up and move around a little. Washing your face can help you feel refreshed.
Most people are perfectly comfortable flying on planes.
If you ve never flown before and fear sickness, see if your doctor can find something that could help if you need it. You probably won t, but once you re on the plane it s too late and you might have trouble contacting your doctor before the flight home. Booking a seat in the middle of the plane next to the wings will provide a smoother ride. The planes are pressurized, but your ears are still sensitive to the change in altitude. The landing is usually worse than the take off.