The current user interface paradigm wastes screen real estate. While useful, neither fully utilizes the scarce pixels they consume. One of the biggest wastes is the vast expanse of gray background material between the controls of current GUIs. Future GUIs will put the user in charge of screen real estate usage. Current GUIs allow users to move and resize windows.
Some current applications allow users to scroll inside the windows.
Beyond that, with few exceptions, the application designer is in charge of what the user sees. The layout within each application window is so important that product success can depend on it. In the future, applications success will depend on how flexible and configurable window real estate is. They will transcend window boundaries and involve multimedia, multiple windows and multiple applications. Whether the hypothesis truly represents brain physiology is beside the point.