They are effective antidepressants, but they also affect many other receptor systems, which may cause a wide range of side effects, as well as toxicity in overdose. Side effects may include dry mouth and constipation. However, they are less toxic in overdose. At standard doses, side effects are similar to those seen with SSRIs. Commonly reported side effects include drowsiness, excess sedation, weight gain and dry mouth.
Side effects can include dizziness, insomnia, dry mouth, urinary retention, sweating and headache.
Every individual is at risk for depression at some point in his or her lifetime. With increasing prevalence of depression-related disabilities and deaths, ongoing education is critical in alleviating many of the misunderstandings surrounding this serious and chronic disease. World Health Organization 2. Improving Outcomes in Depression. NIH web page 8.