Limited functionality of some software compared to individual copies running on individual or locally networked machines. The cost of customizing can be high. If you can't afford the additional costs, you may be forced to use the 'standard' applications, which may not accomplish the job. There may be a long time delay while the ASP applications are integrated into your company system. Off-site technical support and help staffs may not be sensitive to your customers and their needs.
Monthly fees can be high if paying on a per user basis.
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