There is an increased risk of hypercalcemia in patients who are immobilized or who have breast cancer. Testosterone should be discontinued if hypercalcemia occurs. Patients with cardiac, hepatic or renal dysfunction are at increased risk of edema that may or may not be accompanied by congestive heart failure. Use with caution in post-pubertal men as testosterone stimulates bone maturation without a concomitant increase in linear growth. Use with caution in patients with benign prostatic hypertrophy as urinary obstruction may develop.
Testosterone increases cyclosporine concentration increasing the risk of nephrotoxicity.
Heparin doses may have to be reduced. Testosterone increases the effects of warfarin. Warfarin doses may have to be reduced.