The study of the physical structure and physical chemistry of biologically important molecules. The goal is to understand molecular function, understand the genesis of genetic diseases, and guide rational modification of molecules or creation of drugs. True basics Proteins have structure. They are not fluid blobs. Protein structure is determined wholly by amino acid sequence, which is genetically predetermined, and post-translational modifications, which are frequently predetermined.
Proteins recognize the shape and surface properties of other molecules.
The amino acid sequence. Secondary structure, in and of itself, tends not to be stable. The association of several proteins to create a supramolecular assembly. An attraction between an electronegative atom in one molecule, and a hydrogen bound to an electronegative atom in another. The side-chains fold away from the aqueous environment to prevent these energetically unfavorable events.