While the therapeutic administration of proteins in various forms is currently possible, the short biological half-life in vivo and costly manufacturing and storage issues limit this technology. Gene transfer, however, is an extremely versatile technology allowing the production of proteins in the form of growth factors, anti-cytokine molecules, and transcription factors, to name a few possibilities, through which the augmentation of orthopaedic procedures may occur. To date, numerous tissues of the musculoskeletal system, including articular cartilage, meniscus intravertebral disk, bone, tendon, ligament, synovium, and muscle, have been utilized in gene transfer protocols. This presentation will outline current genetic manipulations possible in these musculoskeletal tissues as well as provide a future perspective for the use of gene transfer in orthopaedic surgery. Identify yourself as a Cambridge Healthtech Institute conference attendee to receive the reduced room rate.
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