The University of Missouri-St. Louis is situated on 250 acres of land with 42 buildings.
Most residential housing is located on south campus.
Police jurisdiction is shared between University of Missouri-St. Louis Police Department and the St. Louis County, Normandy, Bel-Nor and Cool Valley Police Departments. Organizations affiliated with the University that maintain off-campus facilities come under the jurisdiction of their local police department. It is the policy of the University of Missouri-St. Louis that, except during normal working hours, all buildings shall be locked in order to maintain the security of both the buildings and their contents.