Contraindications Avoid use in breast feeding women. A. Interactions Toxicity may occur with vitamin A coadministration. Pseudotumor cerebri or papilledema may occur when coadministered with tetracyclines. Isotretinoin may reduce plasma levels of carbamazepine. Alcohol may increase the toxicity of isotretinoin.
Precautions Avoid if possible in women of child-bearing age.
May decrease night vision. Hepatitis may occur. Diabetes patients may experience problems in controlling their blood sugar and plasma triglyceride concentrations while on isotretinoin. Also proceed with caution in patients with preexisting or a family history of hypertriglyceridemia. Avoid exposure to UV light or sunlight until tolerance has been achieved.