No gross or microscopic hepatic lesions were found. Both parameters were normal in the animals sacrificed 30 days later. The formation of this metabolite is enhanced by induction of liver enzymes. The study is well-designed and clearly reported, but of short duration with a limited number of animals. The desired range of toxicity parameters is missing, since the study was designed primarily to investigate liver enzyme induction.
Medium confidence is assigned.
Additional studies pertaining to subchronic or chronic toxicity were not found. However, a great deal of information is available on the metabolism and mechanism of toxicity of brominated benzenes which qualitatively supports this risk assessment. Thus, the data base rates low confidence. Low confidence in the RfD follows. The Health and Environmental Effects Profile for Bromobenzenes received an Agency review with the help of two outside scientists.