If the Cushing's Syndrome is curable, or if iatrogenic Cushing's Syndrome must remain, these individuals will have to cope with persistent fatigue, muscle weakness, abdominal and facial weight gain, depression, mood swings, and all the other signs and symptoms mentioned earlier. Regular visits to a physician for examinations, blood tests, and treatments of infections and complications will be necessary and are often viewed as a sever burden. Iatrogenic Cushing's Syndrome is generally managed by the physician prescribing the steroid hormones for the primary illness, such as asthma, arthritis, or inflammatory bowel disease. Sometimes physicians are able to decrease steroid doses by using other drugs in the treatment of these diseases. Finding the correct diagnosis often requires prolonged testing and even repetition of tests.
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Referrals for surgery or radiation should be coordinated by the endocrinologist, who will also be directly involved in managing the patient afterwards.