Fever should be managed by means of external cooling. Before prescribing medication to suppress or modify cough, it is important too ascertain that the underlying cause of cough is identified, that modification of cough does not increase the risk of clinical or physiologic complications, and that appropriate therapy for the primary disease is instituted. Overdosage of sympathomimetics in this age group may cause hallucinations, convulsions, CNS depression, and death. It may also falsely elevate the VMA test for catechols. Administration of this drug should be discontinued 48 hours prior to the collection of urine specimens for such tests.
Pseudoephedrine is excreted in breast milk.
Use of this product by nursing mothers is not recommended because of the higher than usual risk for infants from sympathomimetic amines. Beta-adrenergic blockers and MAOI may potentiate the pressor effect of pseudoephedrine. Concurrent use of digitalis glycosides may increase the possibility of cardiac arrhythmias. Sympathomimetics may reduce the hypotensive effects of guanethidine, mecamylamine, methyldopa, reserpine and veratrum alkaloids. Concurrent use of tricyclic antidepressants may antagonize the effects of pseudoephedrine.