The half-life of MSM is only 12 hours when consumed within the body. Therefore supplementation with MSM should be repeated both morning and again in the evening. I have had patients take MSM and tell me it did not cure the complaint they were hoping for, but when asked how the rest of their body was doing, I would always find out that some other, more important bodily need, was now for the better. I have not seen any overdose of MSM with any of my patients. MSM is considered very safe.
Toxicity is extremely rare.
MSM is generally non-allergenic. MSM can be taken in bulk form. Its appearance is like a crystalline or flaky, pure white salt. Then one day I overheard an older fellow taking with some friends. These were people I had been working with every week for a long time in a church calling.