This technique was subsequent modified to determine optimal substrates for protein kinases. These studies have also allowed predictions of intracellular targets of signaling proteins on the basis of primary sequence data banks. The yellow stick figures indicate the diacylgylcerol component of the the lipid anchoring into the inner leaflet of the 'green' plasma membrane. Cell 97, 817. Projects Phosphoinositide signaling pathways SH2 and SH3 Peptide Libraries.
Peptide libraries to discover structural basis of protein protein interactions.
Structural basis for regulation of protein kinases. Cell 91, 961-971. Nature 390, 192-195. Recognition of Unique Carboxyl-terminal Motifs by Distinct PDZ Domains. Science 275, 73-77.