New drivers rarely receive a route immediately. In the beginning, they fill in for other drivers or take special trips. It may take several years until they get a regular run. Senior workers may be able to choose their route. All states require school bus and city transit bus drivers to have a commercial driver's license.
Requirements vary by state.
Interstate bus drivers must meet the above requirements as well as be at least 21 years old and pass a physical exam. For more information, contact your state Department of Motor Vehicles.