Study special forms of the disease. Study small populations that had a bottleneck. A. Anatomy Dopamine pathways need to be re-explored because previous studies did not necessarily use good methods. Good methods, which use the dopamine transporter to label the pathways, are now available. Both surveys and focal studies should be done.
Surveys have trouble being funded, even though they are probably useful.
The brain and the spinal cord, especially descending dopamine pathways, should be explored. All pathways into and out of the hypothalamus should explored, because these are important regions for sleep disorders. Particular attention should be paid to dopamine pathways, but opiate and orexin pathways should also be considered. Neuroanatomic studies should be functional, not merely tract-tracing. Receptors need to be considered.