Most members we contacted were eager to go on The Today Show to talk about their results with DHEA replacement therapy. What surprised us was the high percentage of very satisfied DHEA users. We were so surprised by the enthusiasm of these members that we continued to make calls to get a larger sample of DHEA users. We ride our bikes 100 miles a week. This conclusion shouldn't be surprising.
Medical journals are almost always extremely conservative in their recommendations.
A contradiction appearing in the NEJM article on melatonin was its criticism of people who ingest more than 300 to 500 mcg a night of melatonin, thus increasing their serum levels by 10 to 100 times the normal level found in a young person. There is evidence from experimental studies that melatonin influences the growth of spontaneous and induced tumors in animals. Pinealectomy enhances tumor growth, and the administration of melatonin reverses this effect or inhibits tumorigenesis caused by carcinogens. Data on the relation between melatonin and oncogenesis in humans are conflicting, but the majority of the reports point toward protective action. The mechanism by which melatonin may inhibit tumor growth is not known.