John has Pluto in Virgo in the 8th House. The traditional solution to the Nodal dilemma is to balance them. Neither node is inherently wrong, however to have one function to the exclusion of the other is very distressing. Neither John nor Jane is happy. It's not enough now, though.
Nodal positions are unconscious.
This appears to be a fact of life. The Moon is our unconscious emotional patterns and the South Node particularly is difficult to examine. I have found that any transit to either node opens a window of opportunity for growth. Unless it's a conjunction or serious opposition however, it must be consciously explored. Research everything you can find about the sign and house position of your nodes.