Studies on non-CC resistant patients have shown that up to 80 percent of the patients who undergo ovarian drilling ovulate and 60 percent conceive. These patients also display increased CC sensitivity and show minimal adhesion formation. A recent small-scale study on 20 CC resistant patients showed that 70 percent of the patients ovulated after ovarian drilling, and 60 percent of these patients conceived. Ovarian drilling can thus be quite effective but is probably best reserved for patients who wish to avoid gonadotropins and those who are already planning to undergo laparoscopy for other indications. Diet and exercise modification to induce weight loss .
Some patients respond positively to even minimal weight loss.
The response varies widely, however, from patient to patient. In some cases, weight loss alone may not suffice, but it may increase the efficacy of other therapies. Other considerations CC resistant patients are not the only group which ultimately have to consider other therapies. That is, a patient who ovulates on a 50 mg dose of Clomid has a higher chance of conceiving on Clomid than a patient who does not respond until 150 mg. Although some doctors will consider Clomid for up to six months, it is not unreasonable to start examining other therapies after three ovulatory cycles.