There may also be seasonal differences in some species. Included in the animal's normal behavior is the normal response to being handled and examined. Most normal, healthy laboratory animals have a smooth, clean, well-groomed hair coat. Lack of grooming is usually a reliable indicator of dysfunction. Body condition can be assessed from observing the shape and posture of the animals.
Normal animals eat and drink, and void waste products, on a daily basis.
An understanding of the normal food and water consumption, and the nature and amount of urine and feces produced daily are an important aspect of the knowledge of the normal healthy animal. The behavior of animals when eating or drinking should also be noted. In general, most healthy small laboratory mammals are active, alert and inquisitive when they are approached. Normally any disturbance of the animals should produce a response. When handled the animals should feel warm to the touch.