This is from a raised, ulcerated leg lesion from an elderly diabetic male who is a renal transplant recipient. The cerebrospinal fluid was normal as was the chest roentgengram. Infiltrate of activated histiocytes. Round and oval defects contain faintly basophilic organisms that vary in size.
Organisms tend to marginate at the periphery of defects.
Individual organisms separated from neighbor inflammatory cells by symmetrically rounded clear space. Organisms centrally are in cytoplasm of giant cell. Organisms with narrow-based buds are represented. Some of the organisms are concave along one surface. The capsule of the organisms is mucicarminophilic.