He found circumstantial evidence that indomethacin may reduce nitric oxide, and therefore vasodilation, in the cerebral circulation.
Nitric oxide is implicated in a number of headache syndromes.
A group in Europe is testing nitric oxide antagonists in the treatment of migraine, Dodick said. Dodick prescribes indomethacin for patients with unilateral headaches that occur up to 30 or 40 times a day and are accompanied by autonomic symptoms such as tearing or redness of the eye on the affected side and a runny nose. That's where my interest lies. All rights reserved. Republication or redistribution of Reuters content, including by framing or similar means, is expressly prohibited without the prior written consent of Reuters.