My undergraduate years were spent at McGill University, Montreal, Canada. As part of my Biochemistry honors course, I did research in Dr. Gordon Shore's laboratory in the Department of Biochemistry at McGill University. Work in the Shore laboratory focuses on the mechanisms involved in apoptosis. I did a research project in studying the role of the Bap31 complex, in the endoplasmic reticulum, in regulating the activation of initiator caspases. I came to the BCMB program in August 1998.
Microtubules play a key role in the cytoskeleton and MAPs regulate microtubule dynamics.
Work done earlier in the lab indicated that neurofilament proteins have protein domains that can behave as entropic bristles. Since there are protein domains in MAPs that bear structural similarity to the side-arms of neurofilaments, we are asking whether MAPs too contain domains that have the ability to behave as entropic bristles. Copyright, 1997-1999, Johns Hopkins University. All rights reserved.