The expression of these genes is developmentally regulated and specific to certain cell types. Our studies suggest involvement of the novel PLA2 in diseases such as asthma and skin disorders. Further studies are aimed at understanding the complex biology involving these enzymes. Chromosome instability contributes to loss of heterozygosity in mice lacking p53. Altered gene expression in kidneys of mice with 2,8-dihydroxyadenine nephrolithiasis.
Mitotic recombination produces the majority of recessive fibroblast variants in heterozygous mice.
The functions of five distinct mammalian phospholipase A2s in regulating arachidonic acid release. High frequency in vivo loss of heterozygosity is primarily a consequence of mitotic recombination. A reassessment of the low molecular weight phospholipase A2 gene family in mammals.