It proceeds through successive stages of well defined and coordinated sub-processes. Polo is an evolutionarily conserved kinase, active during mitosis.
Meiotic spindles found in mutant testes are generally irregular in shape and structure.
One must look to research in other organisms for an answer to this question. Studies in yeast suggest additional roles for a Polo-like kinase. In addition, mutation can also result in the failure of septation following the completion of nuclear division. In the latter case, cells show a failure both in the formation of a filamentous actin ring, and in the deposition of septal material, suggesting that PLO1 protein is required high in the regulatory cascade that controls septation. Overexpression can also induce septum formation in G2 cells.