When you start any antiviral treatment you may have temporary side effects such as headaches, hypertension, or a general sense of feeling ill. These side effects usually get better or disappear over time. The most common side effects of ddI are diarrhea, headaches, vomiting and rash. Diarrhea, caused by the buffer in the tablets, is sometimes severe. The most serious side effects of ddI are peripheral neuropathy, pancreatitis, and lactic acidosis.
Peripheral neuropathy is a form of nerve damage.
It usually shows up as tingling, numbness, or a sharp burning sensation in the feet, legs, or hands. The nerve damage is usually temporary and will go away if you stop taking ddI, or reduce the dose. If you continue to take ddI after nerve damage shows up, it may become permanent. See Fact Sheet 553 for more information. Pancreatitis is an inflammation of the pancreas, a large gland located behind the stomach.