Therefore, we are investigating the possibile synergy between estrogen and SSRI's in changing serotonin receptor signaling. Activation of hypothalamic post-synaptic serotonin receptors stimulates the secretion of ACTH, corticosterone, prolactin, renin and oxytocin. Therefore, the magnitude of increases in plasma hormone levels after injections of serotonin agonists can indicate the functional state of hypothalamic serotonin receptors. We are investigating the molecular neurochemical and functional correlates of these hormone responses to selective serotonin agonists. These data will provide a foundation for future diagnostic test in patients with serotonin related mood disorders.
Stress increases the secretion of all hormones listed.
The neural pathways and specific neurotransmitters that mediate the effects of stress on ACTH, renin, prolactin and oxytocin are being studied. Psychostimulants adversely influence neurotransmitter systems. Hormonal responses to specific drugs that activate serotonin receptors are used as markers to understand how psychostimulants influences serotonergic neurons.