Therapy should be continued for at least 24 to 48 hours after symptoms and fever have subsided. If i.v. therapy is given over prolonged periods of time, thrombophlebitis may result. Clinical experience with the parenteral administration of doxycycline i.v. Exceeding the recommended dosage may result in accumulation of the drug with an increased incidence of side effects. The further diluted reconstituted solution of doxycycline i.v. should be infused directly into the vein at a rate not to exceed 200 mg over a 30 minute period.
Rapid administration is to be avoided.
Caution should be taken to avoid the inadvertent introduction of the i.v. solution into the adjacent soft tissues. Doxycycline i.v. should not be injected i.m. or s.c. Reconstitute 100 mg vials with 10 mL Sterile Water for Injection. Any unused portion should be discarded. Because of possible incompatibility of doxycycline i.v. with such mixtures, it is strongly suggested that this product be infused separately.