Avoid having skin that is exposed during the peak mosquito times - dawn and dusk. The Anopheles mosquito feeds at night. Use long-sleeved shirts and pants with socks and button up the collar if possible. Sleep in places where mosquito netting is available, as well as having your own personal netting. You can use Permethrin to spray sleeping areas and clothing to keep the mosquito away as well.
Travelers can still develop the disease regardless of how many medications they take.
The parasite has developed resistance to antibiotics over time. Chloroquine used to be the drug of choice but now there are many strains of the parasite that have developed a resistance to this drug. The drug is generally safe but there are some side-affects like nausea, diarrhea and upset stomach. The oral drug is taken once a week for two weeks before entering the endemic area, once a week while in the area and for four weeks after leaving the area. Mefloquine is now the most widely used drug for areas that have parasites resistant to Chloroquine.