Asimov's first law prohibits harming humans. Even merely detecting whether a nearby object is a human is not an entirely solved problem. Asimov's second law prohibits inaction that allows humans to come to harm. Humans are in peril everywhere. Moreover, this law requires predicting the future.
Perfect prediction is impossible.
Asimov's third law requires obeying human directives. The state of the art in natural language understanding is still far from understanding arbitrary directives, let alone obeying them. Nonetheless, it is fun, challenging, and possibly useful to view Asimov's laws as a technical challenge.