An argument may work with one category, but not with the others. Therefore, we need to develop arguments which can fit with each of these groups. We have also to consider which kind of society we deal with. Western Society can be more receptive to scientific arguments. Jewish and Muslim Societies, where circumcision is based on religious arguments, we need first to have this argument reversed.
Religion is first.
Humour and sarcasm With religious leaders, exegeses can be helpful, but there is few chance that these leaders change their mind. With the people, we have to find a way to help them escaping the authority of the religious leaders and texts. Rudiment scientific data will help. But humour or even sarcastic arguments should not be forgotten. Animals do not laugh.