Conditions associated with elevated estrogen levels such as uterine fibroids, endometriosis and premenstrual syndrome may be prevented by normal systemic levels of melatonin. The pineal, primarily through melatonin, acts as a synchronizing and stabilizing organ. Nighttime melatonin levels are low in people with major depressive and panic disorders. Individuals with noticeable mood swings or are melancholy also have depressed melatonin levels. Both seasonal affective disorder and non-seasonal cyclic depressions are related to the peaks and valleys of melatonin levels.
Older individuals have a reduced ability to produce melatonin.
The relationships of endocrine rhythms, mood, sleep and the biological effects of light are complex. Since melatonin secretion declines with age, many researchers believe that it may help prevent age-related and free radical mediated brain damage. Melatonin appears to mediate the entire aging process. The usual recommended range is from one to five tablets from about thirty or forty-five minutes before bedtime. Somniset is not a drug but a natural supplement supportive of natural metabolic rhythms so several days supplementation may be needed to begin seeing results.