Among chronic users, the reappearance of disorientation and visual, memory, and speech disorders has been noted. The drug accumulates in the body. As with other hallucinogenic drugs, PCP does not cause physical dependence. Both Ketamine and PCP have mild effects including feelings of detachment from the surroundings, emotional swings and an altered sense of space and time. Higher doses cause visual distortions and illusions.
Users can also feel a separation from their bodies.
Most users do not have psychotic episodes, but PCP especially is extremely unpredictable. The PCP user exhibits emotional instability, excited intoxication, lack of coordination, and is often impervious to pain. At high doses, PCP is highly toxic and can cause convulsions and coma. Physical effects of PCP include high blood pressure, increased deep-tendon muscle reflexes, respiratory depression, dangerously high body temperature and muscle rigidity. The physical effects of Ketamine are similar but are much milder.