An upshot of this line of research requires identification of genes specific for ovarian cancer . With the recent explosive progress in molecular biology techniques, new methodology is developed to identify rare ovarian cancer-restricted genes. Bast RC, Jr. 1991 Synergistic antitumor activity of different alkylating agents against ovarian cancer . In Vitro Expression of the Diphtheria Toxin A-Chain gene under the control of the hCG gene promoters as means of directing toxicity to ovarian cancer cell lines . Understanding of molecular mechanisms of uterine contraction and preclamsia in women .
Premature labor is a major cause of neonatal handicap and morbidity.
It is as important that the uterus is maintained relatively quiescent until labor, as it is that it contracts in labor. Much good could therefore be done if we understand the cause of these two conditions that is how uterine contractions are initiated. Although many genes for ion channels, G-proteins, hormones and their receptors have been implicated in inducing the labor, none could, either acting as alone or in combination, induce the full magnitude of labor. Our goal is to isolate, clone and study these de novo expressed genes, and to ascertain its functional role in the initiation of labor. To this end, we are currently engaged in construction of a cDNA subtraction library that will mainly consist of de novo expressed genes by preferentially eliminating the genes of non-laboring uterus from the laboring uterus.