Others function in the severe range. Although it is not possible to predict intellectual outcome at birth, intelligence appears to be stable over the life span of most individuals. Seizures occur in about half of all boys with Lowe syndrome. These do not usually require medication unless they recur. In older boys, seizures are usually of a major-motor or generalized type.
Some individuals develop refractory epilepsy or seizures that are difficult to control.
This device consists of an implanted generator and a nerve stimulation electrode which transmits antiepileptic electric signals to the brain through the vagus nerve in the neck. Although boys with Lowe syndrome are often happy, loving, and sociable, many also have a characteristic pattern of behaviors that may interfere with everyday functioning. Some individuals may become violent and self-abusive. These behavioral patterns are thought to be a specific feature of Lowe syndrome. Some studies indicate that for many individuals, the most difficult period for behavior problems is between the ages of 8-13 years.