If this occurs over a few days of continuous riding, check the set up of your bike. Don't ride long distances on successive days if your hands are constantly going numb. Sort the problem out. Prevent numb feet on long rides by wearing shoes with a stiff sole, which fit properly and don't pull the laces or velcro too tight. Sometimes an inner sole helps to spread pressure over a wider area.
Saddle sores are painful lumps which can develop in people who put in long hours of heavy training.
They result from prolonged and repeated pressure causing chronic changes in the subcutaneous tissues of the perineum. If neglected these will grow and become more painful. Corn plasters placed over the nodule when it is first noticed will generally take the weight off the nodule when you ride, and allow it to settle. If it doesn't settle then stop riding for a few days. These can become a real problem if neglected, so don't ignore them.