Alcohol intolerance can occur with any sulfonylurea. People taking chlorpropamide or tolbutamide are particularly susceptible. It's less of a problem with glyburide, glipizide, and glimepiride. To avoid future reactions, simply avoid alcohol. Check your medications, too.
Some cold remedies contain as much alcohol as wine.
Skin Sulfonylureas may cause mild skin reactions, including rash, itching, and hives. Skin reactions usually disappear after taking the medication regularly for a few weeks. If you have severe or persistent reactions, contact your doctor. You may be more sensitive to sunlight if you take a sulfonylurea. As with insulin therapy, weight gain with sulfonylureas can be a big problem for some people.