Fitzsimmons, D., Hodsdon, W., Wheat, W., Maira, S.-M., Wasylyk, B. and Hagman, J . 1996. Fitzsimmons, D. and Hagman, J. 1996. Opinion Immunol . For a list of all publications since 1986, click here. Schematic illustration of the expression patterns of the mb-1 and M17 genes.
Solid arrows indicate expression at stages of differentiation shown above.
Pax-5 is a member of the Pax protein family, which has been implicated in the regulation of cellular differentiation and morphogenesis. Pax proteins recognize DNA via their paired domains, a structure that comprises two separate DNA-binding motifs. In support of this hypothesis, observations in our laboratory provided the first report of interactions between a Pax protein and multiple members of the Ets proto-oncogene protein family. Functional binding sites for BTCs are important for mb-1 transcription in early B cells. Although interactions between transcription factors are quite common, the structural bases for complex formation has only been determined for a very small number of examples.