Speed, fatigue and alcohol kill. Easy to remember - hard to follow. Jet lag is never fatal unless mixed with a rental car. Caffeine is no substitute for sleep. Plan your route in advance.
Maps are hard to read.
Especially when you're cruising along in the left lane of a rain soaked freeway. Beware dangerous lively drivers. Ask a speedy cab driver to slow down - or order him to stop so you can get out and get in another cab. Beware of rental cars. Sometimes hiring a car and driver is the safest thing to do in an unfamiliar city, especially when you're tired.