Beta-blockers leave the vasoconstricting effects of Alpha receptors unopposed. Increased airway resistance. Beta-blockers leave the constricting effect of the parasympathetic system on airways smooth muscle unopposed. Blood lipid effects. Nadolol may increase plasma triglycerides and decrease HDL-cholesterol, which theoretically could contribute to atherogenesis.
Nadolol is effective in treating mild to moderate hypertension.
In severe hypertension, it is useful in preventing the reflex tachycardia that often results from treatment with direct vasodilators. Due to the indirect vasospastic effects of beta-blockers they can aggravate or precipitate angina with a vasospastic component. Peripheral vascular insufficiency. Slow heart rate or AV node conduction problems. Insulin dependent diabetes.