Test code links throughout this Guide refer to the corresponding test in the User's Guide. Treatment with OKT3, however, may lead to the development of inactivating antibodies directed against the mouse protein. Levels will fall before CD3 positive lymphocytes appear in the circulation.
Values are often lower during the first few days of therapy.
Early, abnormal consumption of OKT3 by host anti-OKT3 antibodies can be detected by a drop in plasma OKT3. Hammond E, et al. Wittwer CT, et al. The quantitative flow cytometric plasma OKT3 assay.