No warranties, either express or implied, are made with respect to its accuracy, completeness, or timeliness. The material does not necessarily reflect the current or past opinions of members of the UTMB faculty and should not be used for purposes of diagnosis or treatment without consulting appropriate literature sources and informed professional opinion. Beta lactam ring Connects to a variable side chain. Natural penicillins extracted from Penicillium chrypogenum. Synthetic penicilllins prepared by incorporating precursors in mold culture, by modifying a natural penicillin, or by adding side chains to 6-aminopenicillanic acid.
Penicillins exert their action on actively dividingcells by causing abnormal cell wall development.
They inhibit the 3rd stage of cell wall synthesis i.e. the crosslinking of peptidoglycan polymers via peptide bonds. Neisseria gonorrheae, N. meningitidis. Pasteurella multocida, Streptobacillium moniliformis, spirilium minor. Bacteroides sp., except B. fragilis, Fisobacterium, Peptostreptococcus. Produced by fermentation of Streptomyuces clavuligerus.