Patients on warfarin should be monitored for possible enhanced anticoagulant effects when influenza vaccine is administered. Increased serum concentrations of theophylline have been reported after vaccination. Patients on this medication should be observed for toxicity. The most frequent adverse effects of influenza virus vaccine are local effects including soreness, tenderness, erythema, and induration at the injection site. These local reactions generally are slight to moderate in severity and persist up to 2 days.
Potency is destroyed by freezing.
Although it has been administered subcutaneously in prior years, IM injections are preferred. Store between 2 - 8 C. Do not freeze. Influenza vaccine response in HIV patients. Thompson C. HIV RNA changes in HIV-positive patients following influenza vaccination. J Infect Dis.