Samples should be cultured within 24 hours of being taken to maximize the chances of isolating the organism. This regimen is repeated for five consecutive days. Some mares might require several courses of treatment before the organism is eliminated. Surgical removal of the clitoral sinuses may have to be resorted to in some of these mares to eliminate the carrier state. For males contaminated with the organism, all smegma is removed from the external genitalia while the penis is fully extruded.
Treatment is repeated daily for five days.
One course of treatment usually is adequate to eliminate the organism from the reproductive tract of the stallion. These Codes of Practice are based on comprehensive bacteriological examination of the stallion, and test breeding the stallion to two susceptible mares to check for transmission of T. equigenitalis . Any mares or stallions confirmed positive for CEM should be quarantined and isolated until treatment has proven successful and the animal is proven free of the organism.