Because prednisone is very hard on the gastrointestinal system, most people will be put on Zantac or a similar drug. With the prednisone I took 150mg of Zantac twice a day while on the prednisone and two weeks after as well. When doing that I never had a problem. If I stopped taking the Zantac early my stomach revolted. Your mileage may vary.
Prednisone can cause mood swings.
Eventually we lowered the dosage per day so that I took it for more days, and I also took it all by lunchtime so that I could sleep at night. I took prednisone. This drug is nasty. It makes you hungry when you are so tired you can't exercise. By my experience and the polls I've taken, the average weight gain on prednisone is 30 pounds over 6 months.