Sensitization increases the rewarding properties of addictive drugs.
These expression patterns suggest functional changes that could contribute to increased dopamine release seen in nucleus accumbens with cocaine sensitization. Array studies, in combination with pharmacological, genetic and biochemical approaches, are currently being used to functionally link the regulation of specific genes to behavior of sensitization. We are studying patterns of gene regulation following acute ethanol exposure that correlate with long-term behavioral responses. Studies to date have identified a prominent role of prefrontal cortex in acute responses to ethanol. The gene expression patterns suggest several distinct targets of ethanol action.