Analytical study of cells in cervical squamous cell cancer. Relation of histologic factors to the response of Stage I epidermoid carcinoma of the cervix to surgical treatment. Zaino RJ, Ward S, Delgado G, et al. Grading is based in the degree of architectural differentiation, characterized by the amount of gland formation. The tumor contains well-formed regular glands with papillae.
Mitotic figures are infrequent.
The glands vary from small and round, though angulated shape is characteristic, to large and irregular with complex outlines. Papillary processes are lined by stratified or pseudostratified cells with sporadic mucin and minimal atypia. The tumor contains complex glands with frequent bridging and cribriform formation. Solid areas are more common, but these make up less than half of the tumor. Mitoses are more frequent.