The cause of the discomfort is that God is flooding us. Painful things in our past surface again. If something you thought you had healed comes up again, the reason is because you are still in need of more healing. The level of distress caused varies. If the distress is great, seeing a therapist of some kind may be necessary.
Many people undergo a great transformation sometime around mid-life.
Things they placed their trust in no longer provide them with the security they had up to now. We become more passive, God becomes more active in our lives and we lose control. No one makes this transformation easily, everyone messes it up because we have conscious or unconscious resistance. It is like being back in school again. There are some things in our life that we will not be able to change.