Each patient had bilateral anterior chamber cells. Biopsy of an iris nodule from a patient who had undergone cardiac transplantation confirmed the diagnosis of PTLD, but no signs of systemic PTLD were found. Ocular signs improved slowly after reduction of immunosuppressive drug therapy. Conclusions Posttransplant lymphoproliferative disorder should be considered in the differential diagnosis of uveitis after organ transplantation. Anterior chamber cells and iris nodules are the most common ocular signs, but the posterior segment can be involved.
Ocular involvement can occur without evidence of systemic disease and can be asymptomatic.
Reduction of immunosuppressive drug therapy is an appropriate treatment. Accepted for publication August 16, 2000. Dr Holland is the recipient of a Research to Prevent Blindness Inc, Lew R. Wassermann Merit Award. Fei Yu, PhD, of the Department of Ophthalmology and the Jules Stein Eye Institute Center for Eye Epidemiology, UCLA School of Medicine, and William G. Cumberland, PhD, of the Department of Biostatistics, UCLA School of Public Health, provided assistance with the statistical analysis of data. All rights reserved.