You can certainly use the Jacketed bullets fine, but don't look for incredible speeds. Bullseye is a bit fast for this big cartridge and I don't especially recommend it, but it will work. Unique is better. Reference to Powder UP and Powder DOWN is to actually shake the gun in an up or down position before firing each round and gently bring the gun to the horizontal and shooting. In the large .45 case, a large difference has been noted in speeds.
Normal powders vary quite a bit and also have a larger spread between shots.
For example, No. 9 with 15 gr. With Accurate's 5744 the speeds with 17. 0 were 853 fps UP and 802 DOWN, but spreads were much better at 45 fps and 16.6 fps respectively. So both the up and down positions were closer in speeds and the spreads were noticeably closer. I would conclude this powder is much more consistent in speeds than others that I have tried in the .45 Colt. A Modern rifle should handle these loads equally as well, such as the Winchester Model 94.