Examination of the antidepressant molecule within its receptor cavity allows scientists to predict those areas of the receptor that may be affected by the drug. These sites of interaction can then be changed or mutated. Examination of a number of these mutant receptors with a number of different antidepressant drugs will help isolate the part of the molecule that reduces depression only, and does not produce side effects. A similar processes can be used to develop or improve other drugs. Mental illness research in the U.S. has in the past been funded primarily by the National Institute of Mental Health.
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