Most scientists usually say there are no potential toxic effects of consuming carotenoids.
This is clearly not the case. It is now known that people with pre-existing liver disease can be harmed by excess carotenoids. Therefore, people with hepatitis or alcoholic liver disease should not take large amounts of carotenoids. Drink enough carrot juice and the same effect is possible without underlying liver disease. At least one death from liver failure has been caused by excess carrot juice.