The underlying pathophysiology explains this apparent discrepancy. Lastly, increased attention and awareness required during exercise may confer an antiepileptic effect. How increased awareness might protect against seizures is unknown. Overall fitness and a feeling of well-being have been shown to help reduce seizure frequency. How Epilepsy Treatments Affect Exercise Pharmacologic treatments.
Some medications contribute to poor physical fitness.
Valproic acid and lamotrigine may cause weight gain, but a regular exercise program may cancel this effect. Antiepileptic drug selection must consider individual concerns. A drug such as valproic acid may be an appropriate choice for a marathon runner, but not for an ice skater or gymnast. Thus, serum AED levels of patients participating in regular exercise programs should be monitored closely, especially in the first few months of training. There is no consensus regarding the clinical significance of exercise-induced hepatic enzyme activity.