Renal function tests may be altered, and temporary renal shutdown may occur. Hepatotoxicity has also been reported. For best results, the usual preliminary measures for cholecystography are recommended, particularly in cholecystectomized patients, i.e., a low residue diet on the day before examination and administration of castor oil the night before or neostigmine at the time of examination to dispel intestinal gas, unless contraindicated. After warming to body temperature, meglumine iodipamide is given by slow i.v. injection, following the usual precautions for i.v. administration. It is important that the injection be made over a period of 10 minutes during which the patient should be watched for untoward reactions such as a feeling of warmth and flushing, occasionally nausea.
Nausea indicates that the injection rate is too rapid.
For additional details, see package insert. The appearance of the solution may vary from essentially colorless to light amber. Solutions which have become substantially darker should not be used. Discard unused portion. Vials of 20 mL with sufficient excess for sensitivity testing included.