The methods are similar to Study 13 above. The effect of these substances on the so-called imipramine receptor is also studied. Pure hypericin and pure Kampferol did not have as much effect as the full hypericum extract. It therefore seems obvious that these substances alone do not explain the effect of hypericum. Researchers' comments Because we do not know the therapeutic concentrations in the brain of the leading substances in hypericum extract and which substances make the effect, it is hard to conclude whether or not these results explain how hypericum works.
More research is needed.
It seems likely that hypericum works on both norepinephrine and serotonin reuptake. Recent studies have confirmed that a combination of serotonin reuptake inhibitors and MAO-inhibitors can be very powerful, even at low concentrations.