Outbreaks of disease are most common and most severe during periods of extended rainy weather. Abscesses form directly above the hoof. The abscess contains thick, foul-smelling pus. Infected caribou often limp. Abscesses may also be found in other locations, such as the liver, lungs or mouth.
People are theoretically susceptible to infection.
However, there have never been any human cases of this disease reported in Alaska. Humans should avoid direct contact with pus-filled abscesses. If possible, wear rubber gloves when butchering a caribou with abscesses on the hooves. The meat of caribou with hoofrot is safe to eat. Discard the infected leg.