Very occasionally, i.v. injection of desmopressin has produced local erythema, swelling or burning pain along the course of the vein. In such cases, the dosage should be reduced, frequency of administration decreased, or the drug withdrawn according to the severity of the condition. There is no known antidote for desmopressin. If desmopressin injection is used preoperatively, it should be administered 30 minutes prior to the scheduled procedure. The peak effect is obtained 1 hour after administration.
Response is immediate for bleeding time reduction.
The necessity for repeat administration of desmopressin or use of any blood products for hemostasis should be determined by laboratory response as well as the clinical condition of the patient. Side effects may be decreased by slow infusion. Blood pressure and pulse rate should be monitored during infusion. Ampuls of 1 mL, cartons of 5. It is recommended that the storage of the diluted solutions at room temperature does not exceed 24 hours.