Pharmacological Aspects Instead of using phosphate buffer to solubilize the drug, citrate buffer is used to improve the stability of the fusion protein. To improve the overall drug profile, the fusion protein was truncated from 486 amino acids to 389 amino acids. In the field of cancer immunotherapy, various approaches are in current use or under development. As discussed previously, immunotoxins target tumor antigens in cancers. Therefore systemic administration of cytokines can lead to life-threatening consequences.
More research is needed to improve the specificity of the target.
No. 2, January 1995, pp.399-405.