However, Smad proteins are substrates not only for the receptors, but also for other kinases. These kinases and their impact on the TGFb and BMP signalling are under investigation. Smad dependent changes have been found. Identification of Smad interacting proteins is in scope of our interest as well. It was shown that TGFb treatment of cells led to activation of different regulatory pathways without involving Smad proteins.
Regulatory pathways related to the progression of tumorigenesis, are of special interest.
We are interested in the role of the components of TGFb signalling on different stages of carcinogenesis. As a model, we use human colorectal and breast cancers. Elucidation of this involvement is of our high interest. Interaction of the TGFb signalling with pathways shown to play important role in development colorectal and breast cancers is another high priority aim of our group. Proteomics in application to TGFb signalling Less than two percent of human diseases can be linked to only one gene mutation.