However, the dosage should be administered in not less than 3 to 5 minutes. Local erythematous streaking along the vein as well as facial flushing may be indicative of too rapid administration. A burning or stinging sensation may be indicative of perivenous infiltration and the infusion should be immediately terminated and restarted in another vein. Perivenous infiltration may occur painlessly. Unless specific compatibility data are available, mixing idarubicin with other drugs is not recommended.
Precipitation occurs with heparin.
Prolonged contact with any solution of an alkaline pH will result in degradation of the drug. Personnel preparing idarubicin solutions should wear PVC gloves, safety glasses and protective clothing such as disposable gowns and masks. If idarubicin contacts the skin or mucosa, the area should be washed with soap and water immediately. Personnel regularly involved in the preparation and handling of antineoplastics should have blood examinations on a regular basis. Avoid contact with skin and inhalation of airborne particles by use of PVC gloves and disposable gowns and masks.