Muscle biopsy shows variation in fiber size, necrosis, regeneration, and sometimes, inflammatory cell infiltrates myopathy, miopathy. Usually in the setting of acute weakness in the intensive care unit, frequently discovered because of problems weaning from the respirator. The occurrence of weakness is markedly increased when neuromuscular blocking agents are used in conjunction with steroids for severe asthma. A retrospective study designed to determine the most important predictors of acute weakness of weakness developing in patients with severe asthma requiring mechanical ventilation. The dose and type of blocking agent used was not significantly associated with the occurrence of myopathy.
Pathological findings consist of loss of myosin filaments.
Similar pathological findings have been reported in acute quadriplegia following liver transplantation 2 and autologous stem cell transfusion for breast cancer. Statins Coenzyme A reductase inhibitors have been used for more than 10 years to reduce cholesterol and improved outcome from cardiovascular disease. The mechanism for the myopathic effect is uncertain, although its main mode of action, inhibition of mevalonate, a precursor of ubiquinone which is a central compound of the mitochondrial respiratory chain, implicates a mitochondrial origin. Therefore, although anecdotal reports frequently encounter elevations of CK in patients being treated with statins, studies screening for adverse effects find few patients with this complication. However, no studies specifically monitoring for weakness, CK, and physiological findings have been performed.