They are sometimes solitary at first, but with repeated attacks new lesions may appear and existing ones may increase in size. Lesions may occur around the mouth or the eyes. The genitals or inside the mouth may be involved in association with skin lesions or on their own. As healing occurs, crusting and scaling are followed by a persistent dusky brown colour at the site. This may fade, but often persists between attacks.
Pigmentation tends to be more extensive and pronounced in people with brown skins.
Pigmentation from FDE fades when the causative drug is avoided. Non-pigmenting fixed eruptions have been reported with pseudoephedrine and piroxicam. Local or general symptoms accompanying an FDE are mild or absent. Drugs involved The number of drugs capable of causing fixed eruptions is large. If you have any concerns with your skin or its treatment, see a dermatologist for advice.