The vulva was normal in size and new hair was already growing at the rump and base of the tail area. Lupron depot is safe. It was purple striae on the caudal, ventral abdomen that resolved in a few days. Lupron does not lower cortisol levels or glucose levels. Unfortunately it does not work as well in cases of carcinomas, but it works well in hyperplasia and adenomas.
Preliminary results verify a reduction in the sex steroids and androgen levels.
To do a biopsy study would require surgery. This a drug for ferrets that are not good surgical cases or where owners object to surgery. Thus no biopsy studies have been done. Ultrasound is not an accurate enough test for adrenal gland disease. In addition you would need a control group that was left untreated to compare adrenal gland size differences with.