Death is usually a sudden, unexplained event, presumably due to some sort of brain dysfunction. Back to top Fragile X syndrome Fragile X syndrome is linked to the X chromosome and occurs only in males. It is the second most common cause of mental retardation after Downs syndrome. Boys with Fragile X often have a long face with a large chin, large floppy ears, and enlarged testes. Many researchers believe that there is a relationship between Fragile X syndrome and autism since they share some of the same neuroanatomical features, including abnormal cerebellar development and signs of brain stem dysfunction.
Some individuals develop seizure disorders.
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