The accuracy of male urethral specimens is higher than that for female cervical specimens. Bacterial cultures have better sensitivity for these 3 groups. Alternatives to Gram stain and culture have not been studied in an asymptomatic population. Epidemiological and case-control studies have found that consistent condom use reduces frequency of gonorrhea. There is some epidemiological evidence that spermicidal preparations help prevent infection.
Oral amoxicillin is an effective and inexpensive antibiotic if a non-resistant strain is involved.
Quinolones and cefixime can be administered orally. Citations in support of individual recommendations are identified in the guideline text. This report was externally peer-reviewed. The 1989 U.S. Preventive Services Task Force recommended routine cultures for persons at high risk. The U.S. Centers for Disease Control recommend diagnosis by culture, and treatment for uncomplicated urogenital or rectal infection with one intramuscular dose of ceftriaxone 250 mg, plus doxycycline 100 mg oral twice daily.