Relapses also become more severe with time. In this form of the disease, relapses become more severe while remissions are less complete, shorter in duration, and eventually non-existent. The course of MS becomes steadily progressive. There is no history of relapse in these patients. Disease begins with a slow progression of neurologic deficits.
Problems appear and gradually worsen over time.
Common problems include spastic paraparesis, cerebellar ataxia, urinary incontinence.