Yet the male response to the drug is not as pronounced as that seen in women. However, the results from clomiphene trials are extremely variable, with differing success rates for conception. Therefore, more clinical data are needed to confirm the effectiveness of this drug. Tamoxifen Tamoxifen, like clomiphene citrate, is an oral anti-estrogen compound that has been used to treat male infertility. But, unlike clomiphene, tamoxifen has no estrogenic activity.
Tamoxifen stimulates sperm output by increasing the release of gonadotropins.
In current studies, the most common oral dosage is 20 mg daily. Recent findings suggest that pregnancy may occur in up to one-third of couples in whom the male partner has received tamoxifen therapy. Gonadotropins Gonadotropins are gonad-stimulating hormones. Both HCG and HMG stimulate testosterone synthesis, which, in turn, improves sperm production and pregnancy rates. Antibiotics Antibiotics frequently are prescribed to eliminate infections that could impair fertility, such as infections of the urinary tract and prostate.