We still need to prove that raloxifene prevents bones fractures or lowers the risk of heart disease. Raloxifene doesn't seem to increase the risk of cancer of the uterus or breast. Raloxifene is taken as a tablet once a day. It can be taken with or without food. And you shouldn't take estrogen at the same time, in injections, pills or patches.
Most side effects are mild.
The most common effects are hot flushes and leg cramps. A rare but serious side effect is blood clots in the veins. You have or have had blood clots. You have liver disease or are allergic to raloxifene or any of its ingredients. This handout provides a general overview on this topic and may not apply to everyone.