The dose tends to give a more consistent and predictable level in the blood. An extra step is required before absorption. It takes longer for the drug to start working. You don't always get same level in the blood with the same dose. Bioavailability Proportion of drug that is delivered to the transplanted organ.
More drug reaches the transplanted organ.
The amount of time for half of a constant drug concentration to be eliminated from the body. The drug takes longer to be eliminated. May lead to more frequent drug toxicity if the dose is not adjusted. Patient variability Extent to which certain characteristics of a drug vary among or within patients. Both types often result from varying absorptions, bioavailabilities, half-lives, formulations, food effects, etc.