Doses are adjusted downward if renal dysfunction occurs, and blood levels are used as approximate measures of adequate dosage. Children often require higher doses to maintain adequate blood levels. If biliary drainage via a T tube is used postoperatively, then higher doses may be required because of the loss of cyclosporine via the bile. Mild acute rejection episodes may be self-limited. Jaundice and elevated serum levels of hepatic enzymes are corroborative findings.
Needle biopsy can provide pathologic confirmation.
A variety of complications must be expected, including those attributable to the complex operation itself, in addition to rejection and the consequences of attempts to control it. All rights reserved.