The disorder results in an abnormal skull and head shape.
Most cases are sporadic, although there are several genetic syndromes with craniosynostosis.
Disorders of the fibroblast growth factor receptor molecule have been recently found in some cases of hereditary craniosynostosis. Rarely, symptoms of increased pressure in the head such as headaches, decreased appetite, vomiting, or even developmental delays or mental retardation may occur. The skull bones, coupled with the sutures, form a protective shield for the brain. As the brain grows, the sutures allow the skull to expand rapidly. If for any reason one or more of the sutures closes too early, the skull grows in a different direction where the bones are not resisting growth, thereby resulting in skull deformities.