Many of the other 12 cranial nerves may also be affected, including the 3rd, 5th, 8th, 9th, 11th and 12th. The most apparent symptoms are related to facial expressions and function. In newborn infants, the first sign is an impaired ability to suck. Excessive drooling and crossed eyes may be present. In addition, there can be deformities of the tongue and jaw, and even of some limbs, including club foot and missing or webbed fingers.
Most children have low muscle tone, particularly of the upper body.
Speech problems often respond to therapy, but may persist due to impaired mobility of the tongue and lips. As children get older, the lack of facial expression and an inability to smile become the dominant visible symptoms. Moebius Syndrome is sometimes accompanied by Pierre Robin Sequence and Poland's Anomaly. Some internal anomalies exist including stomach or kidney reflux. Unusually short broad head, unbalanced appearance to the head, Hypertelorism, droopy eyelids, short fingers, webbed fingers.