Nothing is as simple and direct as giving cash.
You can make a general donation to the Sigma Alpha Epsilon Foundation, which we usually direct toward our greatest current need. Stocks or other investments that have grown in value and that you have held for more than one year can become a substantial gift made at a low-net cost to you. You receive a charitable deduction for the donation of these assets, and its based on their fair market value on the date of the gift. But there is a bonus - you avoid all federal capital gains tax that would otherwise be due on a sale of the assets. Or take a capital loss yourself.