Models for well-studied targets such as reverse transcriptase and proteases are not advocated, whereas models for promising new targets such as the nef protein are encouraged. Cell Culture Assays. It is desirable that new cell culture models be developed for HIV replication and AIDS-related malignancies that more closely simulate the in vivo state. In Vivo Models. Models that reflect the current state of knowledge of HIV pathogenesis and are simpler, safer, more relevant and less expensive than currently available models are urgently needed for the evaluation of therapiesfor HIV disease and AIDS-related malignancies.
Novel approaches using transgenic and gene knockout animals are especially encouraged.
Research support mechanism for this PA is the NIH investigator-initiated research project grant R01. The level of support is dependent on the receipt of a sufficient number and diversity of applications of high scientific merit and the availability of funds. The total project period for applications submitted in response to this PA may not exceed five years.