We supply the programs on these HD 3.5 inch disks. It is similar to the algorithm of Mallet, but runs on PC's. It can compute both volume and bioavailability from mixed oral and IV dosing when appropriate serum level data is available for each route. It is designed to accept a population containing up to 999 such files. It can utilize appropriate clinical data including only a single serum level per patient.
Output consists of plots of the marginal PDF for each parameter.
3D plots can be made of the joint marginal PDF for any parameter pair. It also computes traditional mean, SD, mode, median, skewness and kurtosis, and the covariance and correlation coefficients between parameters. In addition, the full joint PDF can be written to a Matlab file for use in RMultiple ModelS adaptive control prototype new software for more precise stochastic design of drug dosage regimens. The program now runs about 30 times faster than previous versions, due to implementation of various methods for accelerating the computations. Drugs include aminoglycosides, vancomycin, TMP-SMX for PCP, digoxin, digitoxin, lidocaine, procainamide, theophylline, quinidine, and gentamicin in newborns.