The answers given are a summary and combination of the doctors' replies. Therefore, even a patient who got pregnant immediately after going off of these drugs would probably be safe, especially since the fetus is not at its most vulnerable to their effects in the earliest part of pregnancy. However, to be on the safe side, we recommend patients go off of the medication for three cycles before trying to conceive. Usually, however, the body can compensate for this effect. We can see the relationship between cortisol and insulin resistance in sleep apnea.
Sleep deficits increase cortisol levels which increase insulin resistance.
In turn, insulin resistance may worsen sleep apnea. However, it should be noted that there is very large inter-individual variation in the potential for drug interactions. Due to cancer, I had a total hysterectomy and an oopherectomy ten years ago. The metabolic abnormalities that characterize PCOS are not dependent on ovarian presence. For example, the adrenal glands can be an androgen source just as easily as the ovaries can.