ProMale is rubbed on the skin as a percutaneous gel preparation. Over a period of several days, the testosterone precursors enter the body and are slowly released into circulation via the lymphatic system. Tests have shown it takes about three days to reach peak steady state levels. This is a true time release technology. Percutaneous gel application of hormones only need be applied to the skin once daily.
Studies show that elevations in plasma levels remain constant throughout the day.
The adequacy of the dose can be checked by one blood or saliva sample. Where the matrix of the transdermal patch acts as a reservoir for hormone delivery, percutaneous gels use the natural reservoir of the skin to deliver a continuous flow of hormones into the body between applications. Variances in individual plasma levels due to differences in skin absorption can easily be corrected by adjusting the volume or strength of the gel used for the optimal physiological effect. Combinations of 2 or more hormones can be combined into a single dose. There is no problem with skin irritations as is sometimes seen with transdermal patches especially in warm and humid climates.