Two-door vehicles sometimes require an adult to be a contortionist to get into the back seat. If your rear passenger will be a small child, check to see if the vehicle offers an integrated child seat. You'll quickly see why two-door sporty cars and trucks don't make good family cars. Some trunks are very deep, or have high sills, forcing you to lift items over the back end of the car and down. Because of this, it can be a strain to put things in and take them out of the trunk.
Many vehicles have an adjustable seat belt mount for driver and front passenger.
Your physical height determines whether or not these blind spots are a hazard. If the vehicle you're considering requires serious shifting, be sure to check the visibility of the tachometer. Many cars are placing the radio above the heater controls, knowing it is accessed far more frequently. A frantic search for the channel knob can have fatal results.