Among the other abnormalities reported were limb anomalies, visceral defects, and visual changes. In animal tests, teratogenic effects were found in rabbits and guinea pigs and were absent in mice, rats, dogs, and monkeys. Quinine sulfate is contraindicated in women who are or may become pregnant. If this drug is used during pregnancy, or if the patient becomes pregnant while taking this drug, the patient should be apprised of the potential hazard to the fetus. Since thrombocytopenic purpura may follow the administration of quinine sulfate in highly sensitive patients, a history of this occurrence associated with previous quinine sulfate ingestion contraindicates its further use.
Recovery usually occurs following withdrawal of the medication and appropriate therapy.
This drug should not be used in patients with tinnitus or optic neuritis or in patients with a history of blackwater fever. Repeated doses or overdosage of quinine sulfate in some individuals may precipitate a cluster of symptoms referred to as cinchonism. Quinine sulfate should be stopped immediately if evidence of hemolysis appears. If symptoms occur, drug should be discontinued and supportive measures instituted. Cutaneous flushing, pruritus, skin rashes, fever, gastric distress, dyspnea, ringing in the ears, and visual impairment are the usual expressions of hypersensitivity, particularly if only small doses of quinine sulfate have been taken.