The highest dose caused 10 of 18 volunteers to drop out of the study because of the large volumes that had to be injected. Two people lost 35 pounds in 24 weeks, one gained 20 pounds, but most lost only small amounts. The mice helped by leptin have a genetic abnormality in which they do not produce leptin. Only a handful of humans have been identified who produce no leptin. We still do not know the role of leptin in humans, but research will continue.
Obesity is a complex condition that has resisted simple, magic bullet solutions.
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