The virus was isolated from the peripheral blood mononuclear cells from 6 adults with immunosuppressive conditions, including AIDS, lymphoma, and leukemia.
Roseola is a benign illness and is a major cause of febrile illness in young children.
Its significance is its ability to mimic more serious causes of high fever and its role in inciting febrile seizures. The fever then ceases abruptly, and a characteristic rash may appear. Mild lethargy and irritability may be present, but generally there is a dissociation between systemic symptoms and the febrile course. The pharynx, tonsils, and tympanic membranes may be injected. Conjunctivitis, coryza, cough and pharyngeal exudate are notably absent.