This progesterone prepares the uterine lining for implantation. It binds to estrogen receptors and causes the brain to think that estrogen levels are much lower than they actually are. Because of this mechanism, a good response to CC requires relatively normal hypothalamic, pituitary, and ovarian function. The twenty percent of patients who do not respond to CC with ovulation are considered to be CC resistant. There are multiple treatment options for these patients and they may take one of several pathways.
Some options involve trying stronger stimulation in order to overcome CC resistance.
Extended CC therapy . The basic idea behind this therapy is simply to use more Clomid. In one approach, the patient takes 250 mg for eight days and then received hCG six days later. In a small scale trial, this approach resulted in ovulation for eight of 12 patients, and three of these eight patients conceived. These results have not, however, been replicated in a larger group of patients.