Nuclear functions charge ahead.
Inside out regulation. Nuclear tRNA aminoacylation and its role in nuclear export of endogenous tRNAs in S. cerevisiae . Competition between a sterol biosynthetic enzyme and tRNA modification in addition to changes in the protein synthesis machinery cause altered nonsense suppression. Overall goals Our research focuses on the intersection of genetics and eukaryotic cell biology. Using budding yeast as a model system we employ a multidiscliplined approach to study pre-RNA processing and mechanisms of subcellular distribution of RNAs and proteins.