Phlebitis, pain or inflammation at the infusion site. Diarrhea, colitis, nausea, and vomiting, Drug fever, rash, pruritus, urticaria, and rarely Stevens-Johnson's syndrome. Decreased prothrombin activity Eosinophilia, neutropenia, thrombocytopenia, hemolytic anemia, and positive Coombs' test. Headache, lightheadedness, and seizures Cholestatic jaundice and slight elevation in LFTs. No clinically significant interactions have been reported.
Potential interaction involves high dose probenecid decreasing cefepime renal clearance.
Cephalosporins, carbapenems, and monobactams. Infect Dis Clin North Am. Giamarellou H. Fourth generation cephalosporins in the antimicrobial chemotherapy of surgical infections.