Avoid vitamin and mineral supplements for rickets. The traditional defects of vitamin D metabolism are not present in hypophosphatasia, and excessive vitamin D can cause hypercalcemia. Activity in children may be hampered by difficulties with gait. While no distinct guidelines have been established, avoidance of contact sports and adequate protection of the teeth would be prudent. Complications of the more severe forms usually involve the respiratory system.
Skeletal deformities can predispose an infant to respiratory compromise or pneumonia.
In the infantile form, craniosynostosis can lead to increased intracranial pressure. The perinatal form is considered lethal. Longevity studies have not been conducted for the infantile and childhood forms. Individuals with the adult and odontohypophosphatasia forms are believed to have normal lifespans. Genetic counseling is important for all families who have affected children.