Osteoblastic osteosarcoma has abundant osteoid ranging from a lace like matrix to thickened trabecular bone. Chondroblastic osteosarcoma has cartilage production and the fibroblastic form has a spindle cell stroma with focal osteoid. Treatment of osteosarcoma is complex. A biopsy must be performed for diagnosis. A chest CT scan and whole body bone scan are performed to rule out metastases.
Preoperative chemotherapy is undertaken before resection.
Post-operative chemotherapy completes the regime. Osteoblastic, chondroblastic and fibroblastic subtypes all have similar prognoses based on tumor size, extent and location. Treatment and Prognosis , W.B. Saunders, Co., 1991.