Department of Pharmacology and Toxicology.
Prostate cancer is one of the major malignancies of men in the Western World.
In 1996, over 140,000 men will be diagnosed with prostatic cancer and 33,000 will die from this cancer. Yet, Asian men, consuming a traditional diet high in soy products have a low incidence of prostate cancer. Asians who emigrate to the United States and adopt a western diet lose this protection. One of the components of soy, genistein has been reported to inhibit protein tyrosine phosphorylation in vitro. Accordingly we have investigated the potential of genistein in the diet, to inhibit tyrosine phosphorylation in the prostate of Lobund-Wistar rats.