Affects the skin, eyes, GI tract and heart. Diagnosis is made by skin biopsy. Higher incidence of optic disc drusen 2. Dx made by elevated serum alkaline phosphatase and urine calcium. Varying reports but angioid streaks are found in approx.
Patients have hyperextendable skin and loose joints.
Usually asymptomatic but visual loss from associated complications occurs with time. RPE detachment 4. Safety glasses and no contact sports 2. No prospective randomized controlled trials of laser photocoagulation for CNVM associated with angioid streaks. Myopia and lacquer cracks, Histoplasmosis, Toxoplasmosis, Choroidal rupture, Choroidal folds References 1.