Atopic subjects do not show a predisposition for sensitization. IgE-dependent mechanism, the betalactamine molecule is an hapten.
Subject becomes sensitive during the preparation or use of the product.
Classic asthma sometimes with severe attacks associated with conjunctivitis, rhinitis and even urticaria. Anaphylactic episodes are possible when the drugs are ingested by subjects who are already sensitive. Eczema is rarely associated with asthma in such cases. Skin rashes are associated with handling of antibiotic powders. Diagnosis References Skin prick tests with allergens conjugated for minor and major determinants.