Serum cholesterol concentration and total lipids usually are increased. Serum lipoproteins are increased, mainly because lipoprotein-X is present. Serum albumin is normal early in the course of the disease, but the globulins usually increase the serum IgM often to very high values. The course of PBC varies greatly. It may not diminish the quality or the duration of life.
Slow progression suggests prolonged survival.
A rising serum bilirubin, associated with autoimmune disorders, and advanced histologic changes indicate a poor prognosis. PBC is one of the best indications for liver transplantation.