Edgerton's Raney was like this for me. Humor can be written in most any genre. For example, Douglas Adam's Hitchhiker's series is really considered Sci-Fi. The Kinky Friedman series are hard-boiled detective novels, and A Confederacy of Dunces is award winning literature. These books are so quotable that you can barely get by a page without heralding whomever is around you with yet another one-liner.
Some writers write about odd characters in some fairly normal situations.
Crazy in Alabama takes place in 1965, the height of the racial tension. Told from the point of view of a childhood memory, Aunt Lucille makes for some fairly hysterical antics. Or take Mack Green , in The Bookmakers , he owns some very unconscious decisions, but the plot turns hilarious as we watch some very ruthless people at work. When the books are this funny, you don't see people feeling sorry for themselves in that redeeming way Oprah likes. OK, they may feel sorry for themselves - Samuel Karnish , Ignatius Reilly , Pamela Trowell , certainly do, but their logic is so honestly deceptive, we can't help but laugh.