When your ovaries stop producing estrogen, your risk of heart disease increases. Hormone replacement therapy may play a role in preventing heart disease. Estrogen, alone, may increase a women's risk of endometrial cancer. Progestin Taken with Estrogen Reduces Risk of Endometrial Cancer Progestin is a man-made form of progesterone. Progesterone is another female hormone which, like estrogen, is released during your menstrual cycle.
Progestin helps prepare the lining of the uterus for a potentially fertilized egg.
Progestins are taken in combination with estrogen to protect you from the development of endometrial cancer. Women who take both progestin and estrogen have a lower risk of endometrial cancer than those women who take no hormones. It is known that estrogen, alone, reduces a woman's risk for heart disease. However, research has not yet been conducted to determine if the combination therapy of estrogen and progestin is as effective in preventing heart disease.