The gender dysphoria can be extreme and it's not uncommon for transsexuals to turn to suicide or self-mutilation. Some transsexuals may cross-dress but for the majority, this alone is not enough and they turn to hormone treatment and sometimes, sex reassignment surgery. Transsexuality is about a person's sense of their gender. Homosexuality concerns sexual orientation. People in transition are aware of the discomfort that others feel and try to work out the best accommodations for everyone involved.
Many transgender people pray their whole life for a cure one way or another.
Finally they have to accept that there is none. Transphobia - is a hatred or fear of transsexuals. Transvestite - heterosexual man who sometimes dresses in women's clothing. Intersex - conditions in which genitalia are not clearly male or female. This includes hermaphrodites and persons with XXY chromosomes.