Pain and photophobia are common ocular findings, which result from purulent conjunctivitis. This usually begins 1-2 days prior to the onset of the rash. The oral mucosa is especially susceptible to inflammation, blistering and erosion. The vaginal tract epithelium may also be involved. Eye involvement may result in bilateral purulent conjunctivitis, which manifests as edema, crusting and ulceration with pain and photophobia.
Many patients require ventilatory support for respiratory failure.
Although the exact pathogenesis of TEN is not understood, most experts agree that it represents an idiosyncratic reaction to a drug or chemical agent. No definitive or specific emergent laboratory tests are indicated. Basic laboratory tests may be helpful in symptomatic or supportive therapy. Leukopenia of uncertain cause may occur. Significant fluid loss may occur.