Dear Sir Humate P is a concentrate of Factor VIII, also rich in von Willebrand factor, made from human plasma. The viral-inactivation method of heating in solution, also called pasteurization, has been very effective. Humate P has been used now for about 20 years with transmitting HIV to anyone. There have been a very few cases of hepatitis which occurred in people using Humate-P, but it is not clear that Humate P was the responsible agent. There is no such thing as a perfectly safe concentrate, or any perfectly safe medication, but Humate P has an outstanding safety record.
Many doctors do use both agents together.
More frequent use is NOT advised because of the possibility of excess water retention. It is very reasonable to require that you remain on the hospital for a few days after nasal surgery. That area is prone to hemorrhage in persons with von Willebrands disorder.