The pulp chamber also appears to be enlarged. The incisors tend to be the most affected. Currently, no medical therapy is available. Various treatments have been attempted including zinc, magnesium, cortisone, plasma, and enzyme replacement therapy. The results have been inconsistent.
Supportive care is necessary to decrease the morbidity associated with hypophosphatasia.
Examine infants and children regularly to check for evidence of increased intracranial pressure. Follow fractures closely. Adult pseudofractures may require orthopedic care in order to heal properly. Rachitic deformities and gait abnormalities require orthopedic evaluation. In order for them to heal completely, pseudofractures of the adult type may require rod placement.