Face flushes, head and neck perspire. Blood pressure is reduced and heart rate accelerates which produces a rushing sensation. The reduction in blood pressure can result in loss of balance and fainting, especially if people are involved in physical activity like dancing. The likelihood of accidents is increased and people with heart or blood pressure are more at risk. Poppers increase pressure within the eyeball and should not be used by anyone with glaucoma.
Regular use can also lead to problems around the nose and mouth.
Swallowing a large quantity can lead to unconsciousness. Some deaths have occurred this way. Long term use can lead to nausea, dizziness, delirium and impaired respiration. Headache flushing of the face decreased in blood pressure increase pulse dizziness relaxation of involuntary muscles especially the blood vessel walls and the anal sphincter. In the UK amyl nitrates are medicines controlled under the medicines act.