The arrival of a large number of females to the Web is a great thing. The only reason people go to these sites is to get some content that the mindless mainstream doesn't have. Sometimes design clouds the content, sometimes design is used to cover-up the fact that there is no content. When it comes to design and content, the person creating a site really has to feel and know what the core content is. Everyone has a unique voice that, in the case of a indie site created by one or two people, is often the core content.
Many people seem scared to embrace and deliver their voice.
They try to cover it up, try to present content in a way that is distracting from focusing on the voice. Nobody has time for this type of insecurity. The audience deserves the voice, the truth, or the site shouldn't exist. I use Netscape and IE 4.0 and I have all the major plug-ins installed. But some of the positive email about my site are often coming from Web TV or a kid in Norway with Netscape 2.0.