Modulate keratinocyte differentiation. Have been shown to reduce risk of skin cancer formation in renal transplant patients. Makes keratinocytes in sebaceous follicles less adherent and easier to remove. Administer as in adults Contraindications Documented hypersensitivity Interactions Toxicity increases with coadministration of benzoyl peroxide, salicylic acid, and resorcinol Pregnancy C - Safety for use during pregnancy has not been established. Etretinate is main metabolite and has demonstrated clinical effects close to those seen with etretinate.
Mechanism of action is unknown.
Keratolytics - Cause cornified epithelium to swell, soften, macerate, and then desquamate. By dissolving the intercellular cement substance salicylic acid produces desquamation of the horny layer of skin, while not affecting structure of viable epidermis. Adult Dose Hydrate skin and enhance effects of medication by soaking affected area in warm water for 5 min prior to use. Remove any loose tissue with brush, wash cloth or emery board and dry thoroughly. Improvement should generally occur in 1-2 wk.