The second line of research explores viral gene transfer methods to enhance the survival and differentiation of neural cells. Genetically engineered cells are studied in culture and after transplantation to the nervous system of rodents with the intent to restore damaged neural pathways. Cellular and molecular neurobiology techniques are used in combination with immunocytochemistry as investigative tools. Ciliary neurotrophic factor promotes the terminal differentiation of v-myc immortalized sympathodrenal progenitor cells in vivo. Developmental Brain Res.
Trophic factors reduce the incidence of programmed cell death in a sympathoadrenal cell line.
The components of cell and gene therapy for neurological disorders.