Most patients will eventually be free of symptoms. However, in some patients, the symptoms are more severe, the duration of the illness may be longer, and the expected recovery may not occur. Careful study of individuals with orthostatic intolerance indicates that the disorder takes a significant toll on lifestyle and work capacity. It is thus very important that physicians attain a better understanding of the causes and treatment of orthostatic intolerance. Probably there are multiple causes for the disorder, including an autonomic nervous system disease.
More research is needed to elucidate causes and identify better therapy for orthostatic intolerance.