Throughout pregnancy the mother had taken phenobarbital and dilantin. Only 1 of the twins had signs of the fetal hydantoin syndrome. In all 4 cases, the mother was receiving phenytoin monotheraphy, and, after birth, the infants had clinical findings compatible with the fetal hydantoin syndrome. Congenital Hydantoin Syndrome Dilantin Syndrome Fetal Dilantin Syndrome Fetal Phenytoin Syndrome Hydantoin Syndrome Multiple abnormalities in infants whose mothers were treated for epilepsy with hydantoin anticonvulsants during pregnancy. The abnormalities include disorders of growth and mental development, dysmorphic facies, and osteoarticular, cardiovascular, and other anomalies.
Neoplasms complicate some cases.
Blepharoptosis, mild hypertelorism, and strabismus. Widely spaced nipples. Umbilical or inguinal hernia. Dermatoglyphic abnormalities consist of abnormal palmar creases. Neuroblastoma, mesenchymoma, and Wilms tumor have been reported in some infants.