Both soft tissue masses and intrabony radiolucencies have been observed. Several unusual characteristic have been ascribed to myofibromas, including rapid enlargement after incisonal biopsy, spontaneous resolution of congenital tumors, and familial cases with autosomal-dominant inheritance. Histologically, myofibromas demonstrate a biphasic pattern formed by nodules of spindle cells in short bundles and whorls separated by more cellular hemangiopericytoma-like zones. The spindle cells have microscopic features reminiscent of both smooth-muscle cells and fibroblasts. The cellularity and infiltrative nature of the tumors can result in the mistaken microscopic impression of a sarcoma.
Treatment consists of local excision or curettage, which is usually curative.
Recurrence is occasionally noted but does not appear to affect the long-term cure of these tumors. Deaths due to tumor are seen only in infants with extensive visceral organ involvement. Ossifiying Fibromyxoid Tumor. While most OFTs occur in the upper and lower extremities, cases affecting the head andneck region have been documented. Clinically, most patients present with an asymptomatic, slow growing nodular mass.