Class I cells are believed to be the main projection neurons of the BLA, whereas class II cells may be local interneurons and class III are neurogliaform cells. Class I pyramidal neurons are reported to be the predominant cell type. Rainnie et al. Class I pyramidal neurons, Class I stellate neurons, and Class II stellate neurons. Late-firing cells showed a hyperpolarized resting membrane potential relative to the others.
Pyramidal neurons are immunoreactive for glutamate and aspartate.
Non-pyramidal cells contain GABA, choline acetyltransferase and neuropeptides. Colocalization of these substances is reported as well. Seizures are a behavioral manifestation of abnormal synchronous firing of neurons in the central nervous system, whereas epilepsy is a neurological disorder characterized by the repeat occurrence of seizure activity. In contrast to simple partial seizures, complex partial seizures involve the loss of consciousness. The kindling model has been extensively use to investigate the cellular changes associated with epilepsy.