Somatotropin pulse frequency and basal concentrations are increased in acromegaly and are reduced by successful therapy. This guideline was developed after a detailed scientific review of the literature. In areas where evidence was inconclusive, the guideline was based on expert opinion in consultation with the Divisions of Endocrinology at the University of Alberta and the University of Calgary. Reference ranges are based on 95 percent of the population. Therefore, results for 5 percent of normal individuals will fall outside the reference range.
Reference ranges are specific to each laboratory.
The diagnosis of endocrine disorders relies heavily on appropriate clinical assessment and interpretation of laboratory results. This guideline is strictly for laboratory testing not clinical practice and management. The Alberta Clinical Practice Guidelines Program promotes appropriate, effective and quality medical care in Alberta by supporting the use of clinical practice guidelines. The program is administered by the Alberta Medical Association under the direction of a multi-stakeholder steering committee. The team encourages your feedback.