Nausea and vomiting Nausea and vomiting are often associated with attacks that involve an overall systemic reaction, such as anaphylaxis. Some people also are nauseated on a more regular basis. Bones Osteoporosis Osteoporosis means literally, porous bones. In mastocytosis this can occur as a result of the presence of mast cells in the bone. It can also be caused or made worse by malabsorption of calcium and bone-building minerals.
Osteoporosis causes bone breakdown, that can lead to multiple fractures and tooth loss.
Although osteoporosis is a more normal finding in post menopausal women, it is found in both men and women with mastocytosis and can appear long before it would be expected in healthy adults. It is diagnosed using several different radiological tests, including bone density scan and x-ray using radiographic dyes. Some mastocytosis patients experience bone pain that ranges from uncomfortable to debilitating. This is thought to be related to the presence of mast cells in the bone. A research project being run by the Mayo Clinic is currently running a study on management of bone pain.