We are interested in the design, synthesis and evaluation of allosteric modulators of ion channel function. Currently, most of our research involves studying allosteric modulators of GABA A receptors. We have prepared two different classes of compounds having unique pharmacological properties at GABA A receptors.
Research projects provide opportunities for training in medicinal chemistry.
Through the participation of collaborating laboratories, students also may obtain additional training in a variety of pharmacological, physiological and biochemical techniques. Hu Y, Wittmer LL, Kalkbrenner M, et al. Reddy PA, Woodward KE, McIlheran SM, et al. Williams KL, Tucker JB, White G, et al. Lactone modulation of the GABA A receptor.