SAMe contains a compound that all living cells produce.
In Europe, where it is a prescription drug, SAMe is widely used to treat depression. However, while study results are impressive, most of the trials thus far have been small, involving fewer participants than depression drug studies. Bear in mind that, like antidepressant drugs, SAMe doesn't work for everyone. Look for tablets with enteric coatings which improve absorption, and also go for the new butanedisulfonate form. Be aware, however, that some experts feel none of the brands of SAMe on the market provide enough of the compound in usable form.