Other formulations of saquinavir are available. Dosing may vary. The AUC of saquinavir was increased to 220 percent when double-strength grapefruit juice was given. Saquinavir soft-gel should be taken with a meal or up to 2 hours after a meal. Saquinavir soft-gel capsules should be refrigerated at 36 to 46 F in tightly closed bottles until dispensed.
Refrigerated capsules remain stable until the expiration date printed on the label.
Once brought to room temperature capsules should be used within 3 months. Saquinavir hard-gel capsules may be stored at room temperature. The most common side effects seen with saquinavir are gastrointestinal disturbances including nausea, bloating and diarrhea. Elevated liver function has been noted with saquinavir. Resistance and cross-resistance.