The good news is that new combinations of anti-HIV drugs can shut down HIV very effectively. A strong combination of anti-HIV drugs stops HIV from making billions of new viruses every day, and can reduce the amount of virus in the body to very little. The less HIV being made, the less chance of random mutations happening. The less mutations there are happening, the less chance that a drug resistant mutation will happen. This is why researchers think that strong anti-HIV drugs like protease inhibitors need to be taken on schedule, and at the right dose.
Researchers also recommend combinations of anti-HIV drugs for the same reason.
Keeping HIV production in the body at a minimum lessens the chance of a drug resistant HIV virus being made. And if a drug resistant HIV virus doesn't get made, the anti-HIV drugs can keep working much longer. This information does not intend to promote or endorse any specific treatment for any health related condition.