Nicotine nasal spray 4. Bupropion C. Antihypertensives 1. Optimal duration of treatment not known. Can be minimized by rotating application site. Nortriptyline may be effective in treating some of the depressive symptoms seen during withdrawal 4.
Noradrenergic activity affects nicotine withdrawal.
Alpha-adrenergic agonist that decreases release of norepinephrine. Not shown to be efficacious for nicotine withdrawal. Antihypertensive that blocks nicotine receptors. Two studies showed an increase in smoking as if to compensate for nicotine blockade. Sufficient evidence is lacking at this time to recommend treatment, but is considered promising.