Following completion of this initial treatment, patients will undergo MRIs to determine the tumor's response to CPT-11.
Patients then receive radiation therapy.
This therapy is given once daily, Monday through Friday, and lasts for five to six weeks. Patients will then have a month off without therapy. MRIs will again be obtained one month after completion of radiation therapy. Finally, patients will start the last part of the protocol, which involves six cycles of oral temozolomide. The drug is given for 5 days and repeated every 4 weeks for a total of six months.