Smokers and premature infants are at risk for deficiency. Individuals with hereditary red blood cell disorders like sickle-cell anemia are also at risk. Individuals who have a hard time absorbing fat, like those with cystic fibrosis, are at risk. It is possible that large doses of vitamin E can interfere with vitamin K's blood-clotting abilities. Other Facts Vitamin E is fat-soluble.
Vitamin E is actually a family of compounds including the tocopherols and the tocotrienols.
High levels of vitamin E are present in lungs, where oxygen is concentrated. The RDA is based on alpha-tocopherol equivalents. According to the Department of Epidemiology at Harvard, the only large, randomized trial found no significant reduction in the risk of coronary heart disease with the ingestion of 50 IU of vitamin E daily. Epidemiologic evidence suggests that high doses of vitamin E may reduce the risk of coronary heart disease. Am J Clin Nutr, Dec. 1995.