All the 100 patients under study had at least one episode of haematuria, which was the commonest symptom. T 1 with Tis. Well differentiated cells with their fibrovascular stalk, thickened urothelium, having more than 7 cell layers with slight anaplasia, pleomorphism and mitotic figures with increased nuclear to cytoplasmic ratio and prominent nuclear membrane. Moderately differentiated cells with wider fibrovascular stalk, greater disturbance of the base to the surface cellular maturation, loss of cell polarity. Nuclear to cytoplasmic ratio is higher with more nuclear pleomorphism and prominent nucleoli.
Mitotic figures are frequent.
Poorly differentiated cells without any differentiation of base to surface cellular maturation with marked pleomorphism, high nuclear to cytoplasmic ratio and more frequent mitotic figures. A strong co-relation do exist between the stage and grade of the tumors. . Higher the number, higher was the grade without any statistical significance. Table II shows the relationship between the stage and grade of our 100 patients. The response to treatment was evaluated by referring to the duration of disease free survival, the number of recurrences and time interval and progression of the disease.