Check out your local listings to find sliding scale counseling centers. There are nationwide resources for support groups and counseling for members of the adoption community. Assure him that just because he has mental illness and disease in his family, it does not mean that he is doomed to suffer the same fate. He should however be extra vigilant about his health and use of substances. Let him know that it is ok to cry.
Real men do cry.
Remind him that there is hope and that he is never alone. There are many other adoptees who feel or have felt just as he does. Good Luck, and be patient with him. Patience and love is what he needs right now. This question was answered by by Kasey Hamner.