Assessment was based on score marks shown in Table 1. Acupuncture with needle dipped in placentrex. The result conclusively suggests that acupuncture with the needle dipped in placentrex solution produces significantly better improvement in vitiligo. In the present study whereas there was no apparently significant improvement with acupuncture alone in 26 patients for a period of 3months, significant improvement has been observed in 21 patients receiving acupuncture with the needle dipped into placentrex solution compared with acupuncture as such in 18 patients treatment lasting for 3 months. In man MSH stimulates melanogenesis and an increase in the pigmentation of skin is seen in a number of disorders where there are elevated level of this polypeptide.
Melanin is a quinonoid of some what uncertain structure.
Tyrosine is a Cu containing enzyme which plays a vital role in converting tyrosine into DOPA which inturn acted upon by tyrosinase forming melanin. Recently placentrex solution has been introduced for local application in vitiligo. Mechanism of action of melanin. Harrison's principles of internal medicine. Bersani G. - Vitiligo and autoimmune poly endocrine deficiencies with auto antibodies to melanin producing cells.