The fibers then break at the nodes of Ranvier and the Schmidt-Lanterman clefts . Bands of Bungner are longitudinally continuous columns of Schmwann cells which proliferate within the basal lamina after the loss of myelinated fibers. Reich granules are in myelinate fibers only. If they are found in a Remak fiber , this implies conversion to a non-myelinating phenotype. Axonal regeneration Regenerating axons sprout from the tips of interrupted axons or from preterminal nodes of Ranvier and grow along bands of Bungner.
New internodes are of equal length, but shorter than the original.
Regenerating clusters may form clusters of Remak cells around a central myelinated fiber. Mellitus is one of the most common causes of neuropathies. The majority of patients have an antecedent infection 1-4 weeks before developing symptoms, which are predominantly motor and usually symmetrical. Distal and autonomic symptoms are also present. There is a characteristic increase in CSF protein without pleocytosis .