Science is explanatory, and the use of natural regularities is necessary for this purpose. Science makes predictions, and the use of natural regularities is necessary for this purpose. Science looks for testability. This has two aspects. E.g., if a planet were discovered going in squares, then the laws would have been shown to be incorrect.
Science is tentative.
A scientist must be prepared to reject his theory. Science should strive for simplicity and unification. Scientists should be intellectually honest. Nor is it clear to me that explanation is necessary for science, although if science is often explanatory. In 4, Ruse should not claim that theories are open to logical falsification.