In one comparison study, it produced the least weight gain of all the atypical agents. Other Atypical Drugs. Studies have not shown any significant difference in benefits among these drugs. The beneficial impact of these drugs is greatest on psychotic symptoms, particularly hallucinations and delusions in the early and midterm stages of the disorder. Side Effects of Neuroleptics.
Neuroleptics can have adverse side effects related to many organs and systems in the body.
Sleepiness and lethargy commonly occur in the beginning of therapy, but they usually decrease over time. Other side effects include dry mouth, eye problems, allergic reactions, weight gain, and menstrual irregularities in women. Sexual dysfunction resulting from treatments is a common reason for noncompliance, although the drug amantadine may help offset this side effect. A much more serious but rare side effect is the neuroleptic malignant syndrome, in which dangerously high body temperatures occur. Sometimes the effects of the drugs mimic schizophrenic symptoms, such as agitation, slow speech, and retarded movement.