Results should be reported to the Health Department. Consult with infectious disease physician before resuming any aerosolized treatment. Repeat AFB culture if persistently positive, and consult infectious disease specialist. Rifampin negates the effects of oral contraceptives. Women using orals will need to switch contraceptive methods in order to avoid hepatotoxicity and achieve contraceptive efficacy.
Rifampin is contraindicated during treatment with all protease inhibitors.
Patients may be placed on rifabutin, as a rifampin substitute, along with indinavir. Continue treat-ment for at least 6 months and 3 months beyond culture conversion. Consult a TB medical expert if the patient is symptomatic or smear or culture positive after 3 months. Consult a TB medical expert if the patient is symptomatic or smear or culture positive after 3 months. The strongest evidence from clinical trials is the effectiveness of all four drugs administered for the full 6 months.