Use with caution in patients with PVCs. May take 2-4 weeks to become effective. Monitor CBC and liver enzymes regularly. Problematic side effects. For short term management of insomnia, anxiety, and agitation.
Regular use can lead to tolerance, addiction, depression, and cognitive impairments.
For treatment of clinically significant depression that presents as a primary or comorbid condition. Selection is usually based on previous treatment response, tolerance, and taking advantage of potentially beneficial side effects, e.g. sedation vs. activation. A full therapeutic trial requires at least 4-8 week. After 9 months, reassess need for medications by dose reductions. Discontinuing medication over 10-14 days limits withdrawal symptoms.