Others suspect loss of hyaluronic acid, which balances tissue electroytes and elasticity. Others suspect increased elastase-type proteases digesting the elastin. Metabolic activity per some is increased, indicating that the skin is not atrophic, but hyperactive, and varies according to the stage of disease. Others found no difference in HLA-A or B levels. LS can be familial, especially associated with B40 and B44.
Progesterone helps about half also.
Cryosurgery also no good. All ages, always with itch. It may be. Elevated white plaques of epithelium may be diffuse or patchy localized, usually bilateral, mostly labia majora, but no resorption. Hyperkeratosis causes white epithelium.