We've seen the effects of not seeking God. Satan told Eve the fruit of the Tree of Knowledge of Good and Evil would make her wise. She got a kind of wisdom all right, but not the kind she was looking for. It's this knowledge of guilt that gives us a problem with the past, meaninglessness in the present and hopelessness for the future. Not only does Genesis give us a look at the past, it looks forward to the future.
Prophecies abound throughout the book.
A study of the prophecies and their fulfillments would be rewarding. We've noted several references to a coming of Someone through whom all nations of the earth would be blessed - the Messiah, Christ. Abraham, Isaac, Jacob and Judah are all told of the Blessed One who would come through their lineage. He will provide redemption to all who seek to be redeemed to God. With that redemption comes a freeing of guilt from the past, meaning for the present and hope for the future.