CNS toxicity is related to rate of metabolism of meperidine to normeperidine. Or a serum ratio of normeperidine to meperidine with ratio greater than 1.0 increasing the possibility for seizures. Naloxone is contraindicated due to its action to remove the depressive effect of meperidine. This may precipitate convulsions. Narcan has no effect on normeperidine.
Seizures are usually of short duration.
Otherwise, treat the patients needs. Meperidine-Induced Generalized Seizures With Normal Renal Function. RF Kaiko et al. Central Nervous System Excitatory Effects of Meperidine in Cancer Patients. Vincent F. Mauro.