There are no studies in humans, and the significance of these findings to humans, if any, is not known. Parafon Forte C8 should be used during pregnancy only if the potential benefit justifies the potential risk to the fetus. Dependence and withdrawal signs have been reported in newborns whose mothers took opiates regularly during pregnancy. These signs include irritability, excessive crying, tremors, hyperreflexia, fever, vomiting, and diarrhea. Signs usually appear during the first few days of life.
Narcotic analgesics cross the placental barrier.
The closer to delivery and the larger the dose used, the greater the possibility of respiratory depression in the newborn. Narcotic analgesics should be avoided during labor if delivery of a premature infant is anticipated. If the mother has received narcotic analgesics during labor, newborn infants should be observed closely for signs of respiratory depression. The effects of codeine, if any, on the later growth, development, and functional maturation of the child is unknown. Chlorzoxazone, acetaminophen with codeine is not recommended during lactation because safety in nursing mothers has not been established.