Studies the role of protein tyrosine kinases in the regulation of cell proliferation. Designs novel protein tyrosine kinase inhibitors as possible chemotherapeutic agents. Designing and testing inhibitors of cancer cell metastasis that target sites of cell adhesion.
Research focuses on reducing toxicities of chemotherapy in children and on supportive-care issues.
Is a member of the American Association of Colleges of Pharmacy, American Society of Hospital Pharmacists and American Pharmaceutical Association. Is member of Indiana University Cancer Center. Has received grants from the National Cancer Institute, American Cancer Society and American Institute for Cancer Research. Has discovered how to construct modified nucleobases that can be used to create probes for the detection of DNA sequences found in genetic diseases, cancer and pathogenic infections. Developing a comprehensive diagnostic system that will be capable of detecting virtually all of the significant genetic mutations that occur in cancer.