Can not passively diffuse across the cytoplasmic membrane, and 3. Requires active transport by aerobic respiration. 3 modes of resistance. Preferential uptake by bacteria. Similar in action to erythromycin- prevents translocation Little clinical resistance at this point.
Peptide synthesis is blocked midcourse.
Neutral compound at physiological pH. Inhibits the activity of the peptidyltransferase, leads to ribosome binding to mRNA and translocating along it without making protein. Antagonizes aminoglycosides by releasing the nonsense proteins being synthesized under the influence of the aminoglycosides. Plasmid-mediated chloramphenicol acetyltransferase. Neutral at pH 7, orally active, competitive inhibition with chloramphenicol and clindamycin. Know principles of antimycobacteria therapy.