It does not have hepatic toxicity and seems to be absorbed through the lymphatics. Hirsutism, does not seem to be a problem. Climacterone is another drug that is available. It is an injectable preparation that consists of testosterone enanthate, estradiol benzoate and estradiol dienanthate. It is given as a deep IM injection every 4-8 weeks at a dose of 1 ml.
Patients have a feeling of well being and there is a positive anabolic effect.
The concern with Climacterone is that there have been case reports of increased hirsutism. Moreover long term use has a marked effect on the lipids and cardiovascular system. It is a steroid that seems to have combined estrogenic, progestenic, and androgenic effects. It has been used in Europe for ten or more years with good success. It comes in a 2.5 mg tablet, taken daily, and seems to help with suppression of vasomotor symptoms, re-establishment of normal endorphin levels, suppression of the hypersecretion of gonadotrophins and prevention of postmenopausal bone loss.