They'll be there when you need them. You won't even be able to leave them behind if you take the computer somewhere else. Accessing a disc that happens to be the one currently loaded is exactly like accessing the disc in a regular 8X CD-ROM drive. If you want to access a disc that isn't already loaded, you have to wait for a few seconds while the changer chunka-chunks the old disc out and the new disc in. The changing and spin-up process only takes from four and a half to five seconds, depending on how many slots the changer has to traverse.
Problems There are some caveats.
The C68E takes about 30 seconds to chunka-chunk its way through all six discs. This doesn't make the problem go away, but it gets it over with when I boot the computer. I think an extra six CD-ROM drives is well worth a 30 second slower system startup time. If you're running two or more applications which simultaneously want to access different discs in the changer, it would flog hopelessly. Realistically, though, I don't know how this could happen, except in a network server with many people accessing its resources.