This method is especially suited for the diagnosis of numerical chromosome aberrations. Two hundred and forty human sperm metaphases have been studied by the hamster technique. The rate of abnormalities in sperm cells corresponds to data currently available. We observed a discordance between the incidence of structural and numerical abnormalities in human spontaneous abortions and human sperm analyzed by in vitro hamster-egg fertilization. Oocytes General aspect It has been shown over the last few years that maturation in the follicle may be independent of ovulation.
Oocyte ageing before fertilization is the main factor responsible for chromosomal anomalies.
In IVF practice, hazardous manipulation may lead to such anomalies. It is very difficult to estimate the quality of oocytes at the time of ovum retrieval as there is no correlation between cumulus maturation and true oocyte quality. Mainly small chromosomes were involved. These findings have been confirmed in our own research. The results of this last study and our data are inconsistent with the correlation reported between maternal age and the rate of abnormalities.