Adenitis, lymphoplasmacytic, multifocal, mild. Mice have one set of teeth that grow and erupt continuously throughout life. Destruction and inflammation of the tooth pulp results in proliferation of odontoblasts, cementoblasts and osteoblasts that produce disorganized masses of dental material in an attempt to repair the tooth. Factors that have been associated with development of dental dysplasia are consumption of powered feeds, malocclusion, frequent trimming, trauma, chronic inflammation and increased age. Maxillary incisors are more prone to dysplasia than mandibular incisors as they are seated in softer bone.
Some sections contain significant inflammation in association with the dental dysplasia.
This may support the theory that dental dysplasia develops in response to chronic inflammation. In addition, some sections contain benign proliferative lesions of the Harderian glands. One examined in conference contained a papillary cystadenoma. Dental Dysplasia in rats and mice. Administration of the chemical by gavage for 2 years resulted in a dose-related increase in the incidence of hyperplasia and benign and malignant neoplasms of the glandular stomach.