In very large doses Hydrastis may cause convulsions and over-stimulation of the nervous system. Long term use of high dosages have caused leucocyte buildup. Signs of toxicity take the form of irritation of the mouth and throat, diarrhea and vomiting. Doses over 2 grams per day should not be taken during pregnancy or in cases of hypertension. Extended consumption of large amounts of this herb have been shown to lower B vitamin absorption and utilization.
Ulceration can occur internally and externally with severe overdosing.
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