Numeric-only bar codes such as Interleaved 2 of 5 can encode many more numbers in a given space than a more flexible symbology such as Code 128. In many cases this is critical. Even if one symbology is capable of making a bar code of the required size, you may get a better first read rate using a different symbology. Note that some scanners, particularly wands, are built for a particular density. Make sure that your input device matches the density of the bar code you will use.
Some bar codes are inherently more readable than others.
This is a case where the symbology is better in nearly every way than the competition. In other cases, you may sacrifice readability for some other requirement. Always use the most readable symbology you can, and test it using the actual equipment you plan to use. Durability Some symbologies are more durable than others. As a rule of thumb, those with better readability are more durable than others.