There may be impairments in mental and physical development, hand-eye coordination, and visual and auditory memory. Hydrocephaly may also occur. In mild cases, symptoms such as seizures, repetitive speech, or headaches may not appear for years. ACC is also sometimes associated with complex multi-system malformations and with several chromosomal anomalies, including trisomy 13 and 18. There are non-nervous system malformations that may occur both with and without chromosomal aberrations such as midline facial defects.
Treatment usually involves management of symptoms such as hydrocephaly and seizures if they occur.
ACC does not cause death in the majority of patients. Mental retardation is nonprogressive. This fact sheet is in the public domain. You may copy it.