We investigate interactions of biological macromolecules. Our particular interests are biosensors, immunoassays, nucleic acid microchip devices, and other protein and nucleic acid methodologies for diagnostic applications. Understanding these interactions is essential for designing and optimizing rapid, convenient, and sensitive tests for medical and environmental applications.
Recent research focuses on solid-phase nucleic acid hybridization.
Kinetic analyses compared hybridization rates for microparticles coated with oligonucleotide at various surface densities. Ongoing research at Argonne National Laboratory focuses on protein engineering. Through phage display and mutagenesis technologies, enzymes and antibody fragments are modified for novel applications. Wilkins Stevens P, Henry MR, and Kelso DM. 1999. Nucleic Acids Research 27, 1719-1727.