Stocks are imported by hysterectomy rederivation or embryo transfer, and the health status of rederived mice is monitored by The Jackson Laboratory's Laboratory Animal Health program.
Mutant mice model various aspects of mammary gland morphogenesis and carcinogenesis.
Some mutations result in hyperplasia and tumor development, others result in impaired ductal or alveolar development and lactation. Mutations affecting mammary involution and apoptotic pathways are also included. Null mutations of genes encoding signal transduction molecules known to participate in mammary carcinogenesis are also represented.