When Rb is phosphorylated it releases a transcription factor that regulates expression of genes encoding proteins critical for DNA replication . Histone phosphorylation helps to induce the higher order condensation required for mitosis. It is thought that cyclins focus direct the activity of the kinases on the proper substrates. They disappear rapidly after their job is done. Disappearance is a consequence of phosphorylation and protease activity.
Oncogenes are genes encoding proteins that can induce such dysregulation.