Research Dr Milne Pharmacoeconomics is the application of microeconomic methods and epidemiology to healthcare delivery, especially drug therapy. Dr Milne has developed economic models for cardiovascular therapies, contraception, treatment of menorrhagia, treatment of leg ulcers, rectal surgery and metastatic breast cancer. He has participated in developing clinical guidelines for management of dyspepsia. Alzheimer's disease and leg ulcers. Diseases related to reproduction have devastating consequences for individuals and the community at large.
Preterm birth is one of the major healthcare problems of the western world.
Rates of preterm birth have remained unchanged over recent decades and current treatment approaches are limited. Other major diseases studied are preeclampsia and spontaneous recurrent abortion. We are actively studying the role and mechanism of action of these prostanoids in induction of apoptosis in fetal membranes leading to loss of structural integrity and premature membrane rupture. In addition we are trying to identify novel receptors and binding proteins for these prostanoids, and explore their anti-inflammatory effects in placental tissues.