Symptoms Syphilis has three stages, each with different symptoms. It usually doesn't hurt, and many people don't even notice it. Even though this sore goes away in 1 or 2 months without treatment, the infection will remain. During this stage, the germs can be spread to others during sex. The second stage occurs about 6 to 12 weeks after infection.
Many people also have swollen glands, headache, fever, upset stomach, a stiff neck, and fatigue.
During this stage, the infection can be spread to others. The third stage, which may take place years later, can include many different symptoms such as skin sores and pain in the bones. If the infection spreads to the brain, a person may lose the ability to think clearly. Some people have heart problems. During this stage, the infection cannot be spread to others.