Aminosalicylic acid Treatment of multi-drug resistant pulmonary tuberculosis. Bacteriostatic in action.
Mechanism of action is similar to that of sulfonamides.
Prevents the synthesis of folic acid in susceptible organisms by competitively blocking the conversion of aminobenzoic acid to dihydrofolic acid. The activity of aminosalicylic acid is partially blocked by aminobenzoic acid. Active only against M. tuberculosis. Resistant strains of initially susceptible organisms develop rapidly if aminosalicylic acid is used alone in the treatment of clinical tuberculosis. This can be delayed or prevented by concurrent treatment with other antituberculosis drugs.