This 15 year multicenter randomized clinical study is designed to evaluate the alternative therapies currently used for the management of choroidal malignant melanoma. The medium tumor substudy is still enrolling patients. Here, patients with tumors up to 16mm in diameter and up to 10.0mm in elevation are randomized between enucleation and radioactive I125 episcleral plaque application. Patients are followed for 10 years. Perspective patients are given a complete evaluation and offered entry into the study.
Treatment is available outside of the study.
Since August of 1996 the Oculoplastics Service has been the major research center for the use of bovine pericardium in oculoplastic surgery. This thin, pliable and non-reactive collagen material is used for wrapping hydroxyapatite orbital implants, and in a variety of eyelid reconstructive procedures. The Oculoplastics Service has been evaluating the use of the Holmium laser in the use of canalicular reconstruction since 1994. Patients with canalicular obstructions from trauma, infection, surgery, and congenital atresia may be eligible for this procedure. Duke University Eye Center, All Rights Reserved.