This is initially dependent on the dynamic activity of the actin cytoskeleton, which will polymerize at the site of contact and provide a means for the recruitment of other surface receptors which stabilize the contact between cells. It also provides a means for the changes in membrane shape that occur as the cell makes contact and gains mobility. At the plasma membrane, bound to lipid, is an actin binding protein called profilin. Once the cell receives a signal through its receptor, profilin is released from the lipid and can now bind actin monomers. Myosin is a motor protein with a globular head that interacts with both ATP and actin.
Microtubules also form a dense network within most eukaryotic cells.
They are remarkable structures called by some the 'conveyer belts' of the cells. They are composed of tightly bound dimers of a and b tubulin. These dimers will assemble into profilaments that will gather into groups of thirteen that form a tube of tubulins. It consists of two assemblies of microtubule triplets at right angles to each other. Colchicine and taxol, plant-derived toxins, both work by inhibiting microtubule function.