Tumor cells in a low pH environment are the most difficult to eradicate during therapy. This would enable us to learn how to manipulate ion transport in these cells to selectively lower intracellular pH, which compromises cell viability, to make cancer therapy more effective. We also examine the effects microenvironmental pH and bicarbonate concentration on gene expression using differential display of mRNA transcripts to identify new therapeutic targets.
Ongoing work includes melanoma, breast cancer, and brain tumor cell lines.
Effects of 42EC Hyperthermia on intracellular pH in ovarian carcinoma cells during acute acidification or chronic exposure to low extracellular pH. Int. Temporal association between alterations in proton extrusion and low pH adaptation. Intracellular pH Regulation in a Non-malignant and a Derived Malignant Human Breast Cell Line, J. Cellular Physiology, in press, 2000. All Rights Reserved. The Thomas Jefferson University web site, its contents and programs, is provided for informational and educational purposes only and is not intended as medical advice nor is it intended to create any physician-patient relationship.