We predict that treatments that interfere with the integrity or function of these cells will also reduce susceptibility of animals to infection by blocking replication in lymphoid tissues. These data suggest that PrP conformational changes associated with spongiform encephalopathies are reversible and provides a valuable tool to study the role of PrP conformation in the pathogenesis of the disease. Furthermore, our findings suggest that b-sheet breaker peptides or derivatives thereof could be used as a novel therapeutic approach to prevent and reverse the PrP conformational changes associated with the pathogenesis of spongiform encephalopathies. Please call the hotel directly to make your room reservation. Identify yourself as a Cambridge Healthtech Institute conference attendee to receive the reduced room rate.
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