An IV should be placed and benzodiazepines should be administered in the severely agitated patient. If poor venous access or severe agitation preclude intravenous placement, intramuscular lorazepam or midazolam should be considered. IV hydration and sedation are initial management considerations. Rule out hypoglycemia via a Dextrostix. Activated charcoal will minimize the entero-hepatic circulation of the drug.
More specific therapy is case specific.
Hyperthermia may be treated by external cooling methods. Seizures respond well to IV benzodiazepines. Phenobarbital or pentobarbital constitute adjunctive therapy. Hypertensive crises may require nitroprusside or other vasoactive substances. Rhabdomyolysis is treated with IV hydration, urine alkalinization and diuretics.