Emerging Rotavirus Vaccines . Several studies have documented that G types 1-4 are the predominant serotypes causing human disease worldwide. The diversity of strains in these countries may be important for vaccine development. The lower efficacy of candidate rotavirus vaccines in developing countries is not fully understood and is likely to be due to many factors. One explanation may be disease caused by VP7 serotypes not covered by current vaccine candidates, alternatively the lack of incorporation of a human P type in the tetravalent rhesus rotavirus vaccine.
Rotaviruses are also a major cause of mortality in calves, piglets, etc - highly infectious.
Similar in many respects to Orthoreoviruses. Transmitted by midges, ticks. No vaccine yet. Acute febrile illness, usually without lasting consequences.