Two or more cytokines in combination cause greater or a different effect. Synthesis of acute phase proteins 6. Inhibition of viral replication 7. The characteristic features of cytokine receptors 1. Large extracellular ligand binding domain with very little cytoplasmic tail.
Many cytokine receptors consist of subunit structure.
Cytokines posses specific high affinity binding receptors, but share common signal transducing secondary unit. The receptors in this family have approx. 200 amino acids. 2. 2 cysteine residues separated by 7 amino acids in the amino- terminal part. Receptors in this family have variable repeats of cysteine rich domains, each containing six conserved cysteine residues.