I m familiar with the positive benefits of methylation agents such as SAMe and trimethylglycine and use the products myself. I ve also been reading cancer research articles about DNA hyper-methylation. I ve done an Internet search and have not been able to find anything specific on this subject. It is not possible to over methylate DNA in healthy cells with methylation enhancement. The body has built-in mechanisms for disposing of unneeded methylation.
Most cancers are methionine-dependent.
Patients with cancer should never take supplemental methionine and should eat a low methionine diet.