I break out in a rash that lasts at least two weeks and itches real bad. Usually where the rash is it will make my glands in that area swell up. Unless you are still taking tetracycline, this is unusual. I'd have your physician check for other problems like lupus, porphyria, etc. There has been a lot of media coverage lately concerning bacteria which have developed a resistance to antibiotics.
Viruses also develop resistance to antibiotics like bacteria.
This is especially seen in treating HIV patients where the virus can easily develop resistance to some of the treatment drugs. However, this is to antibiotics not vaccines. There does not appear to be much resistance to this mode of attack. There is a marked difference between resistance to chemicals and resistance to antibodies. My doctor surgically removed a small, dark freckle from my skin, thinking it might be cancerous.