In such a case, you'd be concerned not only with whether the gage could handle the measurement, but also whether it could survive it. As far as measurement is concerned, you should have no difficulty fitting an engine block into the modular gage and making measurements. It would be the method of delivering the part into the gage that you'd have to be careful about. In this instance, steel blocks and locators can stop the engine block. Once it is positioned into place and stabilized, the gage can do its job.
Modular gages are surprisingly hardy.
The operator should be able to insert parts, make measurements, unload parts, and retool within minutes. For the best accuracy, the contact elements should be kept as clean as possible. As with all gages, measurement will be influenced by any dirt, oil, or other contaminant that gets on the element. Modular gaging is not for everyone. Because the gages are designed for quick shop floor inspection, they're not going to provide the highest level of accuracy possible.