Rarely, patients with WM have lytic bone lesions. Absolute lymphocyte count exceeding 5,000 cells per cubic millimeter. CLL must be differentiated from the lymphoplasmacytosis that may occur as a peripheral blood manifestation of WM. 4. When a lymph node biopsy demonstrates the pathologic characteristic of a lymphoma, this becomes the diagnosis. Chronic cold agglutinin disease.
Patients have a high cold agglutinin titer and no morphologic evidence of neoplasia.
These patients often have a hemolytic anemia that is aggravated by cold exposure. These patients are asymptomatic and should not be treated. A Southwest Oncology Group Study. Tricot G, Barlogie B, Jagannath S, et al. Rajkumar SV, Fonseca R, Lacy MQ, et al.