Larger doses will not have any greater effect, but serious side effects could result. Use caution when driving, operating machinery, or performing other hazardous activities. If you experience dizziness or drowsiness, avoid these activities. Side effects of selegiline Selegiline is generally very well tolerated. Because it is metabolized to amphetamine derivatives, it is typically administered in the morning and at midday rather than in the evening to minimize the potential for insomnia.
Some patients experience gastrointestinal side effects.
Unusual side effects include increased liver enzymes and aggravation of peptic ulcer disease. When administered concurrently with levodopa, the most common side effect is an exacerbation of dopaminergic adverse effects. The physician should then lower the levodopa dose to alleviate these symptoms. This will allow an opportunity to reduce the levodopa dose in response to a worsening of side effects as the selegiline dose is escalated. In case of the following less serious side effects , continue to take selegiline and talk to your doctor.