Initial preclinical and Phase I healthy adult studies reported in the literature were performed with rBPI-23. Bacteremia means the detectable presence of bacteria in the bloodstream. Meningococcemia is a septicemia caused by meningococcal bacteria. Septic shock refers to the dangerously low blood pressure caused by sepsis. The order in which amino acids occur in a protein or peptide.
Sequences uniquely define a particular peptide or gene sequence and can sometimes be patented.
In autoimmune diseases T cells mistake the body's own cells for foreign cells and attack them. Peptide molecules that bind to T cell receptors and reduce the autoimmune response have shown potential in treating autoimmune disease. Normally, a population of bacteria live harmlessly, even helpfully, inside our lower GI tracts. Under certain circumstances, such as hemorrhage, surgery or shock, the gut becomes more permeable and bacteria and their components or by-products leak into the body and enter the general circulation, where they can trigger infectious complications. This is distinct from leakage caused by a penetrating injury, ulcerated infections or other physical breach in the integrity of the intestinal wall, which can also cause serious infections.