Periodic Paralysis Association PPRC Metabolic Disorders Metabolic disorders include a long list of diseases that involve nearly every organ system. Many of these fall into the category of Mitochodrial Disease.
Mitochodrial diseases are quite variable in their features.
This is referred to as clinical heterogeniety. The variability of the mitochondrial disorders is due to the varying amounts of abnormal mitochondria present in involved tissues. Metabolic disorders are considered whole body disorders. All cells are subject to the mutations and damage that can result in this class of disease. It is the distribution, or concentration of the defective cellular component that results in the varying features of disease from individual to individual.