Interactions None significant for this infection Pregnancy C - Safety for use during pregnancy has not been established. Precautions Monitor CBC, blood urea nitrogen, serum creatinine, alkaline phosphatase, and transaminases. Common adverse effects are nausea, vomiting, diarrhea, rash, central nervous system disturbance, anemia, leukopenia, and thrombocytopenia. Adjust dose in renal failure. Although it has fewer toxicities than the preceding drugs, there are insufficient data and enough concerns about efficacy that fluconazole must remain a second-line drug for this infection.
Rifampin increases fluconazole metabolism.
Pregnancy C - Safety for use during pregnancy has not been established. Precautions Cardiac arrhythmia may occur when used with cisapride, terfenadine, or astemizole. May cause nausea, headache, rash, vomiting, abdominal pain, hepatitis, cholestasis, and diarrhea. Adjust dose in renal failure. Arrange for transfer if the appropriate resources are not available.