Traveling with a dog by air is another consideration. Unless it's a seasoned traveler, your dog will probably find flying stressful, so you may want to think twice before subjecting it to the friendly skies. Each airline seems to have its own rules and regulations for canine passengers. You must check with the airline well in advance of your trip. All will require a regulation crate, however, and some sort of documentation from a veterinarian certifying the dog is in good health.
Many people prefer to tranquilize their dogs prior to travel.
Bear in mind, however, that tranquilization may not be absolutely necessary. In fact, because of certain medical considerations, tranquilization may be contraindicated for your dog. Ask your veterinarian for his or her advice in seeing your dog safely to the destination. The above is an excerpt from the American Kennel Club Dog Care and Training Book.