By recycling it back into action it gradually builds up the level of SAMe in the body. It might be expected that the results of this process, if it works, will take more time than ingesting SAMe itself. Methyl groups are made originally by folic acid. TMG , the amino acid methionine becomes methylated. Throw in some ATP and the body makes SAMe .
SAMe distributes the methyl groups to DNA, proteins, neurotransmitters, fats and much more.
Insufficient methylation means poor health. The effective dose ranges from 800 mg to 1600 mg per day. Suggested is 400 mg twice daily. A third tablet may be added at noon if depression doesn't resolve within 2 days. A fourth dose may also be added.