X-ray microscopy provides high resolution images from thick objects, like entire cells, at atmospheric pressure.
Samples can be in a liquid environment, similar to their preparation for visible light microscopy.
Our projects are the first to solve biological problems using x-ray microscopy. Among other findings, we have gained new insights in the development of malaria, examined the chromatin organization of sperm, recorded an initial series of parasite development, and imaged metal contents in alga. The repetitive 48-hour life cycle of the intraerythrocytic infection is responsible for the morbidity and mortality of malaria. Efforts to control this deadly disease must be based on an understanding of the parasite's development in the red blood cells. These images established the base for studies of the parasite's development in unfavorable environments.