This study evaluated the potential for interaction with natural products and cytochrome P450 isozymes by ground cloves, ginger, oregano, sage, thyme, turmeric, chamomile, echinacea and goldenseal, echinacea special, feverfew, Siberian ginseng, goldenseal, and soybean. Aliquots were tested alone and with protease inhibitors against positive controls against the P450 isozymes CYP2C9, CYP2C19, CYP2D6 and CYP3A4. The crude extracts were less active than saquinavir or ritonavir. In combination studies the natural products potentiated the inhibitory activity of the protease inhibitors. The infusions also had significant activity against the isozymes.
Natural products used for their perceived benefit to health can affect the four isozymes studied.
The total daily combined ingestion of spices, teas, soybean, and therapeutic agents could result in clinically significant drug interactions affecting the safety and efficacy of these products. The effect of these products on clinical outcome needs to be studied. Alkaline extraction of wheat bran fraction prepared by a novel pre-processing gave a nonstarch polysaccharides. N1G 2W1, Canada. However this requires knowledge of the response factors of the PAD detector.