Genetics Stanford University School of Medicine Dr. Sun obtained his Ph.D. from Shanghai Medical University in China in 1988. In particular, he is interested in understanding androgen independence in prostate cancer and mechanisms that govern growth and proliferation in tumor development. Recently, he joined the department of Surgery and Genetics at Stanford as an Assistant Professor. Dr. Sun focused on understanding the transcriptional processes that govern the transformation of normal mammalian cells to neoplastic state.
Transcriptional control is a key step in the regulation of eukaryotic gene expression.
Our laboratory is focused on understanding the molecular mechanisms of transcription factors that govern the transformation of normal mammalian cells to neoplastic state, with a special focus on nuclear hormone receptors. Current efforts in the laboratory are focused on studying the biological roles of these factors in both in vivo and in vitro systems. The long term goal is to determine whether these interacting proteins can be targeted for the development of novel diagnostic and therapeutic strategies for related human diseases. Androgen Receptor interacts with a novel MYST protein, HBO1. Smad3 represses androgen receptor mediated transcription.