Appropriate treatment of a secondary exacerbating condition has not provided adequate symptom relief.
Symptoms interfere with quality of life.
Patient desires drug therapy. The pharmacologic management of restless legs syndrome is often a rewarding experience for both the patient and the physician. There are a number of established therapies that work in most cases of RLS and some secondary medications that are helpful in at least some cases. Because RLS is a diverse, chronic, and progressive disease, the treating physician must be aware that different types of patients will require different medications and that, in the course of a patient's illness, it may become necessary to modify therapy several times. With suitable treatment, almost all patients can achieve a substantial relief from their symptoms, with a resulting significant improvement in their quality of life.