In turkeys, the symptoms are usually mild and may be unnoticed unless nervous disorders develop. During an outbreak, turkeys will produce eggs with a chalky white shell. Reduced production in breeder flocks is the main economic loss from this disease in turkeys. The flock history, signs of a respiratory nervous disorder and other typical lesions often may be sufficient to allow a tentative diagnosis. Usually, however, the disease cannot be differentiated from infectious bronchitis and some of the other respiratory infections, except by laboratory methods.
Vaccination is practiced widely and is the recommended method for prevention.
Several types of vaccines are available but the most successful and widely used is the mild live virus vaccine known as the B1 and La Sota types. The vaccines may be used by drops into the nostril or eye, addition to the drinking water or applied in spray form. Broiler chickens are usually vaccinated when seven to ten days of age. Chickens kept for egg production are usually vaccinated at least three times. The vaccine is given when birds are approximately seven days, again at about four weeks and a third time at about four months of age.