There first treatment attempts, however, were hampered by technological difficulties. Medical Ozone generators have since been developed and refined. They differ from industrial generators in their capacity to deliver the purest Ozone-Oxygen mixtures in needed amounts. A critical advance in medical ozone technology was the development, in the early 60's of plastics which could adequately carry this mixture and permit proper administration to patients. In the last few years Ozone treatment has seen growing interest from diverse therapeutic groups.
Ozone is a powerful oxidant.
Of importance to biological systems is Ozone's interaction with tissue, especially blood. In this manner, it is calculated that the dose of Ozone administered will perform its therapeutic functions without disrupting blood composition. The production of Ozone-Oxygen mixtures for human and veterinary applications is subject to important technical consideration. It is the nitric oxide which at one time was considered toxic, but in actuality plays an important role in bringing about the health of the immune system and the maintenance of optimum health. Caution is needed not to mix ether and ozone, an especially reactive mixture.