Detection limits vary depending on the compound of interest but are generally in the range of 50ng full scan and can be as low as 10ng. By using selected ion monitoring, detection limits can be lowered to 200pg. A typical sample injection volume is 1 to 3 ul. It can be temperature programmed from -70 to 400 degrees Centigrade. The mass spectrometer can be operated in either the electron ionization or chemical ionization modes and can acquire data on positive or negative ions.
Molecular weight allows confirmation of elemental formulae.
The fragment ions provide information necessary for structure elucidation. Comparison of retention time and spectra with standards is required for positive identification. Quantitative results can be obtained using external or internal standards.