The eruption may be preceded by vaccination or an upper respiratory or gastrointestinal infection. Headache, myalgias and arthralgias are common. Skin Typical skin lesions are reddish-blue or violaceous papules, plaques, or nodules. Massive subepidermal edema sometimes produces a deceptively vesicular appearance. Lesions may be studded with pustules.
Papules often coalesce into circinate or arcuate plaques.
The face and extremities are primarily affected, characteristically in an asymmetric distribution. Ulcers and bullae are more common in malignancy-associated disease, may be extensive and are generally harder to treat. Mucosal lesions Oral lesions can occur but are not common. Conjunctivitis and episcleritis may also occur and are the most common eye manifestations. Sweet syndrome has the potential to involve several other organ systems.