These diseases are characterized by an imbalance between bone formation bone resorption. The molecular pathways that lead to this imbalance are being probed with a combination of cell culture and animal models. Ultimately, this research will lead to new strategies for treating and, ideally, preventing these socially and economically important conditions. We use histomorphometry, radiography, densitometry , and immuno-histochemistry with the aim of improving treatment options in children with cancer. Accrual of bone mass while young may depend on the type and amount of exercise.
Related factors seem to be age and hand dominance.
Structural changes and mechanisms are being studied using DXA and pQCT to understand the mechanical controls of bone remodeling. We perform quantitative gait and motion analysis on subjects to evaluate the effects of surgery, physical therapy, or other treatments. Examples of patient populations include pediatric patients with cerebral palsy and adult patients with soft tissue sarcomas.