RNA cleaving agents which are structure-specific are being developed as well. Combinatorial Chemistry in Ligand Design. Ligand-ligand interactions are important in dictating geometry and stability of metal ion complexes, yet the influence of these interactions on metal ion properties is frequently difficult to predict. We have turned to dynamic combinatorial chemistry to aid us in our design of new ligands. Selection of the desired metal ion complex may be accomplished by a variety of methods.
Recent efforts focus on liquid-liquid extraction.
New mixed ligand complexes are selected that have properties superior to those of complexes with a single type of ligand, demonstrating that there is a cooperative effect between ligands. These results suggest that new ligands and combinations of ligands can be readily obtained from virtual libraries. RNA Cleavage and Phosphate Diester Transesterification by Encapsulated Lanthanide Ions.