Treatment is surgery only. There is an intermediate risk for disease recurrence in these patients, although it is not clear that postoperative radiation therapy improves survival. It does, however, decrease the risk of local relapse. Following surgery, it is important that patients be given the opportunity to participate in clinical, postoperative radiation therapy trials. Following surgery, vaginal cuff radiotherapy with or without pelvic or whole abdominal radiation may increase a woman's chances of survival.
Progesterone is used for metastatic endometrial cancer.
This group of women have distant spread of the disease at the time of diagnosis. The chance of cure in this group is, unfortunately, low. If possible, patients can participate in a clinical trial. Palliation of symptoms can include hormones, chemotherapy, or radiation. Recurrent disease Recurrence is more likely in women with advanced disease and in those whose tumor had certain high-risk features.