In a double-blind prospective trial of 20 patients with established OA, oral glucosamine was tested against placebo for six to eight weeks. 7 Articular pain, joint tenderness and restricted movement were alleviated more rapidly and more significantly with glucosamine therapy than with placebo. However, patients taking glucosamine had a greater reduction in pain after eight weeks of therapy. Claims have also been made that glucosamine protects the joints by making synovial fluid thicker and more gelatinous, thereby providing a better cushioning effect. The symptom reduction rate was 50 per cent in the glucosamine group versus 30 per cent in the placebo group.
Pharmacists can play an important role in advising patients about glucosamine.
Before patients begin self-medication with glucosamine, they must understand the symptoms of OA, and the risk factors for the disease. The incidence of OA is related to heredity, excess weight and traumatic injury to a joint. Anyone who suspects they have OA should consult their physician without delay. Self-medication for OA may not be necessary or can be limited if the patient makes lifestyle changes. These programs can alleviate joint stiffness and pain.