The most common crosslink of cisplatin involves the intrastrand linkage between two adjacent guanine bases. Note the different limiting toxicities of each compound. It has been suggested that exposure to cisplatin can lead to a multi-drug resistant phenotype. Neutralizing radicals formed on biomolecules. The goal of radiation therapy is to selectively target the tumor.
Radiation generates large numbers of radicals along the flight path of the particle or photon.
A common feature of radiation is breakage of chromosomes.