When lithium salts are taken in combination with thiazide and loop diuretics, there are increased plasma lithium concentrations with the risk of toxicity. Inappropriate use Diuretics are over-prescribed in the elderly. They are used at too high a dose, for too long and are often used for inappropriate indications, such as gravitational oedema, which usually responds to activity such as walking. Lack of monitoring in this age group results in the appearance of more side-effects and pharmacists play a useful role in being alert and referring to the GP where appropriate. Diuretics are also used by women to relieve fluid retention often associated with hormonal changes in the menstrual cycle.
Some women use diuretics in the misguided notion that they reduce weight.
Pharmacists should be alert to this abuse and discourage it.