Each piece comes with detailed instructions by industry makeup artist Scott Ramp. Scott has taught this stuff professionally for over a dozen years. He prides himself on being able to teach this to literally anyone. Yes, with proper care. Follow the removal and storage directions included.
Patience is a virtue, remember.
Depending on your choice of application, these can be worn for hours and hours. Prosthetics are worn on movie sets all day. Not that anything bad will happen, but you'll mess up your pillows and freak out if you look at yourself in the middle of the night in the bathroom mirror. If you know positively that you are allergic to makeup or adhesive, you probably want to steer away from this type of thing. However, most people who are allergic to adhesives are NOT allergic to the mild adhesives on double sided tape and most medical adhesives are designed for the most sensitive of skin.