Recommended as a component of proposed state rivers system. The San Francisco River Box, Canyon Hot Springs and Natural Bridge are identified as a significant natural area. The upper reaches are noted for deep canyons with stands of ponderosa pine, juniper, cottonwoods, box elder, and Arizona sycamore. Principal recreation uses are hiking, photography and scenic vistas. Wildlife includes bighorn sheep, whitetail or Coos deer and Rocky Mountain mule deer.
Many hot springs occur on lower reaches and are popular for recreation.
Other recreation uses include hiking and fishing. Prehistoric remains are evident in canyon walls, cliffs and caves. Rock art is also evident. Wildlife includes bighorn sheep and desert mule deer. Channel and flathead catfish, carp and suckers are plentiful.