Each simulator investigates another force potentially stopping the long-term effects of slightly deleterious mutations. The simulator available simulates deleterious mutations in a finite population to estimate the amount of damage Mullers Ratchet can to to a single asexual population. See also the description of scientific background .
Simulators currently use individual based modeling for their stochastic simulations.
This means that each individual gets its own place in RAM main memory. We do not recommend calculation of models that need more memory than physical RAM is available, as usage of virtual memory excessively slows down computation . Thus, the more individuals are simulated, the more RAM is needed, and the longer does it take to calculate the results, as each individual has to be computed for each moment in the simulated history. You can choose the amount of RAM and CPU-time you are willing to commit, so that you get a simulation you actually will be able to handle on your computer. To do that, just select the corresponding keys from the pages listed here .