Frank blindness subsequently develops, which can respond to immediate therapy. However, even with prompt treatment, complete loss of vision is a common sequela. Thus there is a compensatory increase in the respiratory rate. Respiratory suppression may ensue, requiring intubation. In addition to the progression from drowsiness to stupor and to coma, ocular findings are prominent on careful neurological examination.
Visual complaints necessitate a thorough examination of the fundi.
Optic disk hyperemia occurs early in the course of the methanol intoxication. The pupillary response to light is compromised and subsequently is lost. Little to no retinal damage is observed. Accidental overdose can be seen in children. Methanol is commonly found in antifreeze, perfumes, paint solvents, photocopying fluid, and windshield washing fluid.