The aim this project is to provide a test set of biochemically characterised proteins, their coding sequences and their genomic context. This test set can then be used to calibrate gene prediction tools. The choice of the start codon depends on position and on context. The project aims to provide a test set of proteins for which there is biochemical evidence about the translation initiation site. P06349 Signal Peptides Implemented in 1999.
Many proteins contain signal peptides at the beginning which are cleaved off afterwards.
The aim of the project is to provide a test set of proteins for which the existence and length of the signal peptide has been biochemically characterised. The test set will then be used to calibrate prediction programs which predict these signal sequences. Further reading Rolf Apweiler, Alain Gateau, Sergio Contrino, Maria Jesus Martin, Vivien Junker, Claire O'Donovan, Fiona Lang, Nicoletta Mitaritonna, Stephanie Kappus, and Amos Bairoch. Proceedings of the Fifth International Conference on Intelligent Systems for Molecular Biology Bairoch A., and Apweiler R. 1997. Nucleic Acids Res.