Edelman JM, Turpin JA, Bronsky EA, Grossman J, Kemp JP, Ghannam AF, et al. Oral montelukast compared with inhaled salmeterol to prevent exercise-induced bronchoconstriction. A randomized, double-blind trial. Exercise Study Group. Ann Intern Med.
Several questions come to mind.
My last concern is that a journal that is held to high standards by its subscribers should print an article that raises such questionable ethical concerns, especially when the benefit from the knowledge gained from the study is negligible. When issues such as these get past institutional review boards, peer-reviewed publications are obligated to weigh the risks versus the benefits of medical research. Eric P. Brestel, MD Greenville, NC 27858 References 1. Edelman JM, Turpin JA, Bronsky EA, Grossman J, Kemp JP, Ghannam AF, et al. Oral montelukast compared with inhaled salmeterol to prevent exercise-induced bronchoconstriction.