The vaccine also interferes with interpretation of titers possibly for years after vaccination. However, there are some kennels that require Bordetella vaccinations before the dog can be boarded. The intranasal vaccine seems to provide marginally better protection than the injectable form. The dog should receive a booster 2-4 weeks after the initial vaccination, if given the killed injectable vaccine. A single dose of the intranasal vaccine is likely to be sufficient in a puppy older than 14 weeks of age, when the maternal antibodies have dropped to undetectable levels.
Protection seems to be incomplete regardless of vaccine type.
As the intranasal vaccines are modified live, they have the advantage that they elicit a much better, longer lasting immune response. Intranasal vaccines are also quicker in breaking through the maternally derived immunity and are not associated with fibrosarcomas. The disadvantage is that some cats will show mild signs of disease, which may upset the owner, but rarely require veterinary intervention. Chronic ulcerative gingivostomatitis is a hypersensitivity reaction to persistent caliciviral carriage. Thus, we do not recommend boostering repeatedly, as it may lower the protective titer leading to prevention of clinical signs but not eliminating the virus.