It has been shown that these solutions are toxic to human fibroblasts, thereby inhibiting collagen synthesis and the formation of granulation tissue. These same solutions are also cytotoxic to lymphocytes and should not be used as a means to control or treat wound infections. Therefore these solutions are not recommended for cleansing wounds or moistening gauze dressings. When the wound requires a greater cleansing capacity, commercial wound cleansers containing surfactants may be indicated.
Surfactants are reactive chemicals than can harm cells.
Generally, the stronger the cleanser, the more toxic it is to cells. Thus, as the wound becomes cleaner, saline could be substituted for the wound cleanser. Clinicans need to exercise cautionin selecting a wound cleanser as several have been shown to be toxic to human fibroblasts.