Let your veterinarian make sure your pets vaccinations are completely up to date since your pet will be exposed to many other animals along the road. You will want to check with your veterinarian to find out if the area you are traveling in may have some unique problems. Many other areas of Canada and the U.S. will expose your pet to heartworms. These parasites will gain access to your pet through the bite of a mosquito. There are areas which have a tick population which may expose your pet to Lyme's disease.
Pets frequently become very nervous when traveling and can suffer motion sickness as well.
Prior to your trip, if your pet is not used to traveling, take several short trips to get it used to the car and its motion. A pet with a large meal in its stomach may be more prone to motion sickness. If motion sickness is a real problem, your veterinarian can prescribe a mild tranquilizer or motion sickness medication. If you plan to stay in motels or hotels, check to make sure they allow pets. During your trip stop often and plan to take along a good leash and collar so that you can have control of your dog when making rest stops along busy highways.