The clinical features of neuroblastoma depends on the size and location of the tumor 17 . Primary tumors that arise in the head and neck may show as a palpable mass. Horner syndrome is sometimes found. There may be abdominal pain and a palpable mass. Lower thoracic tumors often have no symptoms.
Tumors located in the pelvis can cause constipation and urinary retention.
A presacral mass may be discovered on rectal examination. Numerous symptoms can be found with tumors that arise in the paraspinal area. Disease that has spread to the lymph nodes usually brings about an increase in size of the nodes. Bony disease commonly shows as pain. Esthesioneuroblastoma is the name given for tumors that arise in the olfactory bulb, a structure that contains several types of nerve cells that provide us with the sense of smell.