Antigen Source Drug hapten complex of digoxin covalently linked to human albumin Production Process Healthy sheep are immunized with a digoxin-albumin conjugate. The plasma is harvested and after fractionation, the antibodies are isolated by affinity chromatography Indications For treatment of life threatening acute digoxin and digitoxin intoxication. Digoxin Fab binds molecules of digoxin, thus reducing the amount of free digoxin available to bind to its receptor. The dose amount varies according to the amount of digoxin or digitoxin to be neutralized. For adults about 240 mg is enough to reverse most cases of toxicity.
Most allergic reactions are rare.
The plasma is fractionated. Indications For post-exposure prevention of hepatitis B infection. Hepatitis B Immune Globulin functions to neutralize the hepatitis B virus. Dosage and Route Given immediately after exposure, preferably within 7 days and repeat 28 to 30 days after exposure. Antigen Source Inactivated Rabies virus.