The analgesic effect is short lived, but the neuroactive metabolite is toxic. Accumulation of this metabolite produces increased cardiac stress due to relative depression of output, as well as an increased risk of seizures. Meperidine should not be used around the clock for more than 48-72 hours. TOP Tramadol Tramadol is a unique non-opioid analgesic that acts on opiate receptors as well as producing serotonin reuptake inhibition. There is no apparent addictive potential.
Nausea is the most common side effect.