In most places the prevalence is about 4-6 per 100,000. In many cases, the causes remain to be identified. In the absence of this gene, none of the male traits can develop. Affected women look like normal females, but they do not have a womb. Breast development is normal and the body form is distinctly feminine, but the vagina ends as a blind pouch.
Psychosexual development is that of a normal female.
A neural tube defect characterized by absence of the forebrain, front part of the skull and overlying skin. Affected infants are stillborn or die within hours of delivery. Can occur in families with spina bifida, but the mode of inheritance is not understood. Neural tube defects can be diagnosed during pregnancy. In some cases, the disorder is found in children who have inherited both chromosomes 15 from the father and who lack a maternal 15.