Future studies of NSE in large populations of patients with SE are necessary. If the evidence holds, new drug regimens in the treatment of SE may utilize such a marker in addressing efficacy. Correlating specific markers of neuronal injury with cognitive outcome, quality of life, and duration of SE will provide increasing awareness that SE, including complex partial SE, is a medical emergency requiring prompt treatment. References Meldrum S. Metabolic factors during prolonged seizures and their relation to nerve cell death. Advances in Neurology, 34.
Status epilepticus in well-oxygenated rats causes neuronal necrosis.
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