It's probably because his characters have so often lacked conventional screen emotions that his movies seem cold. Biology seems to motivate them more than humanity. They seem like just a higher level of animal, acting according to instinct. Cronenberg seems to think so. He also seems to think that we want to view our existence as something more than that.
Nature is in the past.
Evolution is in our own hands. It's weird twist on existentialism. Instead of creating our own values, we're creating our own bodies. In the movie, the game pod is almost like an organ. This one of his signature fantasies.