Nabumetone should be taken with a glass of water. If stomach upset occurs, take with food. Nabumetone should be avoided in those with a history of peptic ulcer or GI bleeding. Use during the third trimester of pregnancy is not recommended. Nabumetone is not recommended for use in nursing mothers.
Nabumetone can increase the effect of anti-coagulants.
Because of the potent nature of this medicine, be sure to tell your doctor about any other medicines you are taking, including nonprescription medicines and vitamins. The most frequently reported side effects include diarrhea or constipation, dizziness, drowsiness, gas, headache, increased sensitivity to sun or ultraviolet light, and nausea. More serious side effects that you should report right away include blood in urine, black, tarry stools, chest pain or irregular heartbeat, difficulty breathing, skin rash, redness, blistering, peeling or itching, stomach pain or cramps, unusual bleeding or bruising, red spots on the skin, unusual tiredness or weakness, yellowing of the eyes or skin, ringing in the ears, vomit that looks like coffee grounds and any other unusual gastrointestinal symptoms. Signs of a possible allergic reaction are rash, swelling and difficulty breathing. These symptoms should be reported immediately.