Also, while it is true that Anne's extra finger was considered evidence of her being a witch, if was mostly a trumped up adultery and treason charge that got her beheaded. While I know this doesn't refute your using her as a correlation of how folk with birth defects were treated as satanic, it might be better if you're armed should someone decide to dispute you on this. Perhaps you simply require a short series of night classes to catch up with the events of recent centuries. It is easy to fall behind. This indicates that this condition is a deviation from a biological pattern, and influenced by cultural conditions.
Transsexuals are people burdened with a severe handicap.
Since the brain is the seat of the identity, the driver and master of the body, and the body the vehicle of the brain, then having the wrong vehicle, one which cannot be driven correctly is a grave problem. The only rational correction for this horrific situation is to address the birth defect and correct the body. It is also the only possible solution, for if it were possible to change the brain, it would mean the death of the identity, to be replaced with a new person, which would be murder. Birth defects other than transsexuality are caused by stress on the mother, which in turn affects fetal development in the womb. This is clearly a case of mutation, a deviation from the biological norm, caused by social effects, in this case, religious beating.