Many products contain salicylates.
Those listed below are only a small sample. Initially, central respiratory stimulation leads to respiratory alkalosis. Later, through interruption of the Krebs cycle, uncoupling of oxidative phosphorylation, stimulation of gluconeogenesis, increases in lipid metabolism, increased tissue glycolysis, and inhibition of amino acid metabolism, metabolic acidosis may develop. Younger children, patients with chronic salicylate exposures, and patients with very large ingestions generally develop metabolic acidosis with respiratory compensation. Older children and most adults with mild to moderate ingestions usually develop respiratory alkalosis.