Oxaprozin should be avoided in those with a history of peptic ulcer or GI bleeding. Oxaprozin should be used with caution in those with liver problems. Oxaprozin should be used with caution in those with a history of heart problems, high blood pressure or fluid retention. Oxaprozin is not recommended during pregnancy or in nursing mothers. Safety and effectiveness of oxaprozin in children have not been established.
Oxaprozin can increase the effect of anti-coagulants.
Daypro may blunt the effectiveness of blood pressure medicines. Because of the potent nature of this medicine, be sure to tell your doctor about any other medicines you are taking, including nonprescription medicines and vitamins. The most frequently reported side effects include diarrhea or constipation, dizziness, drowsiness, gas, headache and nausea. More serious side effects that you should report right away include blood in urine, black, tarry stools, chest pain or irregular heartbeat, difficulty breathing, skin rash, redness, blistering, peeling or itching, stomach pain or cramps, unusual bleeding or bruising, red spots on the skin, unusual tiredness or weakness, yellowing of the eyes or skin, ringing in the ears, swollen ankles or feet, vomit that looks like coffee grounds and any other unusual gastrointestinal symptoms. Signs of a possible allergic reaction are rash, swelling and difficulty breathing.