Plans are underway to develop protocols to investigate the toxicity and carcinogenicity of Isoeugenol. It is a know Michael acceptor and is expected to react with either food stuffs or proteins in the target tissues. Toxicology data is very limited. There is a CAS number for Methyl Styryl Ketone that refers to unspecified isomers of Methyl Styryl Ketone. Metabolism studies are underway.
Plans are underway to develop protocols for comparative disposition and short-term toxicity studies.
For most of these solvents, there was evidence for human health risks particularly occupational cancers and respiratory toxicity found in epidemiology studies, from cases reports, from acute and subacute testing in animals from inadequate chronic exposure studies. Stoddard solvent is a mixture of numerous hydrocarbons derived by refining crude oil. There are various types of Stoddard solvent with different flash points and composition of linear alkanes, cycloalkanes, and aromatic hydrocarbons. In 1990, production volume was about 38 million pounds. NTP is developing protocols for toxicity and carcinogenicity studies.