Because of low plasma levels, only peak concentrations could be accurately compared for a ponsinomycin effect. These data are consistent with an increase of DHE bioavailability in the presence of ponsinomycin, probably related to a reduction of its first-pass elimination. 3 MEZZ AN 86298383. TI Comparison of pharmacodynamic effects and plasma levels of oral and rectal ergotamine. AB Plasma levels and the vasoconstrictive effect of 1 mg ergotamine tartrate given as tablets or suppositories were compared.
Rectal ergotamine is thus more biologically active, for the factor used, than oral ergotamine.
We suggest that a rectal dose of 1 mg ergotamine tartrate should be tried as the initial dose in the treatment of migraine attacks. In contrast, similarly prepared F1 recipients rejected BN SBT, thus demonstrating donor specificity. Ag in MLR while they maintained normal alloreactivity to BN stimulators.