Large sheets of epidermis are not seen separating from the underlying dermis. Vesicobullous diseases such as pemphigus or bullous pemphigoid. Withdraw all medications that are not absolutely necessary, especially if begun within 1 month of the onset of the eruption. Do not rechallenge the patient with suspect medications. Skin biopsy may be useful to confirm the diagnosis and rule out other blistering diseases.
Surveillance cultures are often useful in monitoring for infection.
Ophthalmologic care to minimize ocular damage is essential. Aggressive pulmonary toilet has been advocated.