Results from a number of studies suggest that amprenavir can be used effectively as part of a three-drug combination therapy regimen.
Resistance develops more quickly if viral load is still detectable while using treatment.
Like other approved protease inhibitors , amprenavir directly inhibits the HIV protease enzyme, one of the key enzymes that HIV needs in order to reproduce. The most dramatic effects seen with amprenavir to date have been in people who used amprenavir in combination with two nucleoside analogue drugs. Combinations with other drugs may prove equally potent or more potent as additional studies are conducted. When comparing the results achieved with different drugs, it is critical to know which form of analysis is being used since the numbers vary so widely between the different types of analysis used. Both forms of analysis provide a useful but incomplete picture of a drug's effectiveness.