Decrease in estrogen-androgen ratio causes acceleration of groth of facial hair. Androgens continue to be produced mostly by the adrenal cortex. Androstenedions is converted to estrone in the peripheral body fat and its rate conversion increases with age. A percentage of androstenedions are converted to estrone. The more body fat, the more estrone is produced by conversion.
Menopausal women develop thin and wrinkled skin.
It was shown in a randomized clinical trial that women who used estrogen replacement after menopause maintained their premenopausal skin thickness whereas the placebo group had progressively thinner skin with less collagen in the dermis as they aged. Women who replace estrogen after menopause are also less likely to lose teeth in both upper and lower jaw and less likely to require dentures than women who don't take estrogen. Atrophy can also affect the bladder and result in incontinence, urinary frequency, dysuria and nocturia. Other systemic symptoms include anxiety, dpression and irritability and fatigue due to estrogen deficiency. B-lipotrophin modulates endorphin levels which are associated with depression.