Soto's syndrome is a rare genetic disorder characterized by excessive physical growth during the first 2 to 3 years of life. Clumsiness, an awkward gait, and unusual aggressiveness or irritability may also occur. Although most cases of Soto's syndrome occur sporadically, familial cases have also been reported. There is no standard course of treatment for Soto's syndrome.
Treatment is symptomatic.
Soto's syndrome is not a life-threatening disorder and patients may have a normal life expectancy. The initial abnormalities of Soto's syndrome usually resolve as the growth rate becomes normal after the first few years of life. Developmental delays may improve in the school-age years, however, coordination problems may persist into adulthood. The knowledge gained from these fundamental studies provides the foundation for understanding how this process can go awry and, thus, may eventually give clues to understanding disorders such as Soto's syndrome. Dictionary of Medical Syndromes.