In normal arteries, the release of acetylcholine is a signal that causes the tissue lining the arteries to release nitric oxide, which causes the arteries to dilate and that is one of the important mechanisms of blood pressure regulation. In fact, the first thing that has been found in the development of atherosclerosis, long before there is any visible plaque or fatty streak, is that the arteries fail to dilate in response to acetylcholine and this is the first indication that atherosclerosis is developing. It is possible to reverse that failure with arginine. Nitric oxide was originally discovered to be physiologically important in dilating arteries as a substance called EDRF - endothelium derived relaxing factor. Scientists who discovered that nitric oxide is endothelium derived relaxing factor got the Nobel prize for it.
Nitric oxide is an important regulator of blood pressure.
There are some cases of hypertension that are not related to lack of nitric oxide but many cases of hypertension are caused by inadequate production or release of nitric oxide. In fact, all mammals use these nutrients, so there are many pathways in the body for handling these substances that have been conserved by evolution, not like xenobiotic materials such as herbs or drugs that you have to use with much more caution. After hundreds of millions of years, the biochemical bugs in these metabolic pathways have been pretty well worked out.