However, these techniques require a large scale sample preparation. These are great advantages of MS in the structural characterization of a protein. In the present commentary, it will be described how to study the tertiary structure of proteins using hydrogen-deuterium exchange in conjunction with mass spectrometry. J. Mass Spectrom. As the development of X-ray crystallography and NMR, tertiary structure of proteins has come to be investigated more precisely than before.
Mass spectrometry is also an effective tool to analyze the structure of large biomolecules.
In addition, computational chemistry enables to study the protein-ligand interaction. This commentary explains how effective mass spectrometry and computational chemistry are in the analysis of structure-function relationships of biomolecule networks, indicating the resutls of mass spectrometric characterization of immunoglobulin G2b and analysis of computational chemistry of the binding of immunoglobulin G2b and its receptor. J. Mass Spectrom. In PSD analysis most of the expected product ions succeeding from the precursor GPI-anchored peptide were fully obtained. 2000 Presolar grains are defined as grains which had formed in the circumstellar envelope or supernova ejecta and remain intact during the formation of the solar system.