Identification of a genetic marker of risk might allow screening for the disease and early diagnosis.
Molecular studies can identify predisposing genes and elucidate their function.
Such information is of general importance, as more common, non-familial, forms of such cancers may involve somatic mutation of the same gene. While most breast cancers appear to be sporadic, some families have an inherited susceptibility to the disease that can be traced through consecutive generations. Moreover, these families often have a high incidence of other cancers, such as ovarian cancer. The aim of the Programme is to locate and identify genes involved in susceptibility to breast cancer, and to evaluate the biological significance of the hereditary component in the disease. As genetic markers for the disease become available, the feasibility of DNA screening for breast cancer susceptibility in high-risk families will be evaluated.