Drug and active metabolites decrease the viscosity of blood and improve erythrocyte flexibility. Results in increased blood flow to the microcirculation and an increase in tissue oxygen levels. Significant first-pass effect. Excreted in the urine.
Night cramps symptomatic of peripheral vascular disease.
Intolerance to pentoxifylline, caffeine, theophylline, or theobromine. Recent cerebral or retinal hemorrhage. Safety and efficacy in children less than 18 years of age not established. Geriatric clients may be at greater risk for manifesting side effects. Angina, chest pain, hypotension, edema.