A prospective, uncontrolled study was conducted over 6 years. Blood samples were analyzed by using a fluorescence polarization immunoassay analyzer TDx model by Abbott Laboratories. A university-affiliated district hospital. Serum phenytoin concentrations on intravenous and oral phenytoin. Contrary to data in the current literature, reliable serum concentrations in premature neonates were achieved by oral administration of phenytoin suspension.
Oral therapy offers a number of advantages and considerably reduces the cost of therapy.
Due to substantial variations in phenytoin pharmacokinetics in neonates, close monitoring of serum concentrations is required. Further investigation is required to confirm these results, especially in neonates younger than 20 days' postnatal age and those receiving products other than Epanutin.