The pronghorn is found only in sagebrush, low sage, bitterbrush, grassland, pinyon-juniper, riparian, and alkali desert scrub habitats. Also use shrubs and rolling topography for cover. Low rolling terrain and open vegetation used for reproduction. Free water apparently necessary. The amount of water consumed varies inversely with the quantity and succulence of green vegetation consumed.
Pronghorns prefer low, rolling topography in open grassland and sagebrush communities.
Mostly crepuscular, but may be active day or night. Pronghorns may migrate between summer and winter ranges. In spring, winter herds break up into smaller groups. Home ranges are extremely variable, depending on habitat, year, and location. During periods of extreme winter weather may restrict activity to very small areas.