Heroin wears off after a couple of hours, thus requiring several hits each day. Methadone, on the other hand, lasts anywhere between 24 and 72 hours, depending on the dose taken and individual metabolism. DTF - 1 mg in 1 ml. Occasionally, chemists will be broken into and pharmaceutical methadone powder will come onto the market. This stuff is very strong, so if you ever happen to come across it, be extremely careful with how much you use, especially if you are only used to street smack.
Many users claim that the problem with methadone is that it lacks heroin's intensity.
In blind trials, users who were given both drugs orally were unable to distinguish between the effects of the two drugs. Where heroin does have a real advantage over methadone is in withdrawal. Withdrawal from heroin should be over after seven to ten days. Withdrawal from methadone though can take up to a month or even longer. From what I have been told Doloxine seems to be a somewhat psychotic way to detox.