The contrast with normal skin accentuates the thickened dermis and collagen alterations seen in collagenomas. Positional cloning of the gene for multiple endocrine neoplasia-type 1. Clinical features and screening. Perivascular cells harboring multiple endocrine neoplasia type 1 alterations are neoplastic cells in angiofibromas. Medicine is a constantly changing science and not all therapies are clearly established.
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