Ken Woodside, BS The Effects of HLA Mismatch and Crossmatch Status on Early Liver Allograft Function and Survival Preformed antibodies can lead to the rejection of kidney and other allografts. While these tests have predictive value in kidney transplantation, there has been long standing controversy on their predictive value in liver transplantion. Liver allografts seem to be substantially more hearty then other abdominal allografts. It has been suggested that this is due to the organ's relative size or the phagocytic ability of hepatic macrophages and other cells. Unlike other solid organ allografts, the liver can be transplanted across HLA type and against a positive crossmatch.
Preliminary results indicate that none of the criteria have significant effects.
This project is funded internally.