Research Techniques Renal physiology with a focus on the neural and endocrine control of kidney function in various physiological and pathological states. Studies using various animal models and man Have developed a model of essential hypertension in the miniature swine Studies involve chronically instrumented conscious animals Experiments may involve or utilize acute or chronic exercise Research Summary My laboratory research focuses on renal and cardiovascular function in a wide variety of physiological and pathophysiological states. Studies involve the delineation of the functions of the renal nerves and renal endocrines in hypertension, cirrhosis, an d during an exercise stress. At present, work involves the role of nitric oxide as a modulator of renal sympathetic nerve activity, and also, the effects of prolonged hypertension on left ventricular hypertrophy.
Nitric oxide attenuates the renal hemodynamic responses to increased sympathetic nerve activity.
Nitric oxide inhibition causes an exaggeratd pressor response in Yucatan miniature swine.