If the presentation is with a febrile seizure, a seizure workup may be indicated. Typical ballooning cells may be seen in any affected organ system with HHV-6 infection. At present, there is no medical antiviral therapy for the HHV-6 infection that causes roseola. Thus, treatment is supportive. It is not recommended that infants who have had a febrile seizure secondary to roseola receive acute or chronic anti-seizure medications.
Pediatric consultation is recommended for the infant with febrile seizures.
Inpatient care consists of support with antipyretics and treatment of gastroenterologic, respiratory, hematologic or CNS complications. The infection is spread through saliva in both acute and chronic phases. In roseola, there are rarely complications. Given that seroconversion is practically universal, it is rare to find any of the complications that have been reported in the gastrointestinal, central nervous system, pulmonary and hematopoietic systems. It is not expected that children who have seizures with roseola will have further febrile or non-febrile seizures.