For an image demonstrating this project, click here . This is a collaborative project with Profs. Peter So and Roger Kamm of the MIT Center for Biomedical Engineering. For updated information on our single cell signaling project, see MIT graduate student Hayden Huang's home page . Small mechanical strains selectively suppress matrix metalloproteinase-1 expression by human vascular smooth muscle cells.
Mechanical strain suppresses inducible nitric oxide synthase in cardiac myocytes.
Matrix metalloproteinase inhibition attenuates early left ventricular enlargement after experimental myocardial infarction in mice. The transcriptional profile of mechanically-induced genes in human vascular smooth muscle cells. Targeted Deletion of MMP-9 Attenuates Left Ventricular Enlargement and Collagen Accumulation after Experimental Myocardial Infarction. Regulation of Cardiomyocyte Mechanotransduction by the Cardiac Cycle. The Impact of Calcification Upon the Biomechanical Stability of Atherosclerotic Plaques.