For long term therapy, the dose of prednisolone should not exeed 10 mgs per day. Contra Indications Prednisolone is contraindicated in peptic ulcer, acute psychosis, cushing's syndrome, herpes simplex keratitis, CHF and in lactation. Precautions Precaution has to be taken in diabetes, hypertention, Psychological disturbances, osteoporosis, post menopausal women, pregnancy and in chronic nephritis. Longterm use of Prednisolone can cause cushing's habitus, hyperglycemia, muscular weakness, increased susceptibility to infection, delayed wound healing, and psychiatric disturbances. Interactions Efficacy of prednisolone is reduced by Aminoglutethimide, Antacids, Barbiturates, Carbamazepine, Griseofulvin, Mitotane, Phenylbutazone, Phenytoin, Primidone and Rifampin.
Prednisolone reduces the amount of potassium in the blood.
Digitalis can cause Cardiac arrhythmias if hypokalemia occurs. Immunization should be done very carefully. Prednisolone causes edema, excess sodium may cause hypernatremia, hypertension, and water retention. All rights reserved.