Changes in blood flow by progressive obliteration of vascular lumen induced by a radiation repair reaction. Experimental study of central and peripheral nervous system tolerance to radiation. This tolerance is important to define therapeutic ratios. Sparing structures in and around brain tumors and arteriovenous malformations is the main goal of any therapy and the major limiting factor of radiosurgery. Appropriate protection by chemical agents and schemes of radaition fractionation are under study.
Radiation is known to affect neuronal firing.
An acute increase in firing immediately post radiation with mild doses have been confirmed in our laboratory and in clinical studies. The ideal dose of radiation that would control a seizure focus in a long-term and still maintain neuronal integrity is under study in our laboratories. This study promises to define treatment of selected forms of epilepsy that today depend on a major surgical procedure.