There were no significant differences in the frequency of these events. In most cases, bone pain was controlled with non-narcotic analgesics such as acetaminophen. Darbepoetin alfa, an erythropoiesis stimulating protein, is being explored for its potential to stimulate the production of red blood cells. Phase 2 clinical trials are also underway in the oncology setting in the United States, Europe, Canada and Australia. Secondary HPT is a consequence of kidney failure, and many renal disease patients suffer from this condition.
Pegylated proteins have an increased plasma half-life.
Phase 3 clinical trials to evaluate its safety and efficacy have been completed an a BLA was filed with the FDA in the first quarter of 2001. Mucositis is a condition in which the lining membrane of the mouth, throat or gastrointestinal tract is damaged by some forms of cancer treatment. Darbepoetin alfa is an erythropoiesis stimulating protein being explored for its potential to stimulate the production of red blood cells. Phase 2 clinical trials are underway in the oncology setting in the United States, Europe, Canada and Australia. Anakinra is a recombinant anti-inflammatory protein being studied to determine its safety and efficacy in treating patients with rheumatoid arthritis.