If controlling the yeast infection proves difficult, oral antibiotic therapy for the acne may be impractical. When antibiotics don't work, isotretinoin taken by mouth is the best treatment. This drug has revolutionized the treatment of acne, but it can have very serious side effects. Isotretinoin can harm a developing fetus, and women taking it must use strict contraceptive measures so they don't become pregnant. Most people who use isotretinoin develop dry eyes, chapped lips, and dryness of the thin skin lining the penis or vagina.
Petroleum jelly can usually help relieve the dry skin.
Therapy generally continues for 20 weeks. If more therapy is needed, it shouldn't be restarted for at least 4 months. Dermatologists sometimes treat inflamed cysts or abscesses by injecting corticosteroids into them. Occasionally, a doctor may also cut a cyst or abscess open to drain it. Dermabrasion, a procedure in which the surface of the skin is rubbed with an abrasive metal instrument to remove the top layer, may help remove small scars.