Approximately thirty-eight buildings were located on the property, including administrative buildings, dormitories, maintenance facilities, and single family residences, along with farmed land, woodlands, wetlands, and streams. The Choptank River borders the property to the north. A residential community is located east of the site. Commercial businesses located along Route 50 border the property to the south. Shoal Creek, the Cambridge Wastewater Treatment Plant and a shopping center are located west of the property.
Municipal water is available, but residences to the east rely on groundwater for potable water.
Two farms operated at the property until it was purchased by the State of Maryland in 1912. The original hospital was constructed in 1915, including English Hall, Unit 1, Unit 2, and the power plant. Until recently, portions of the site had been farmed by patients or local farmers. Dredge spoils from the Choptank River were piled on the property until discontinued in approximately 1988. The spoils were contained within a six foot high bermed area on the southwest portion of the property.