Papillary histology was the most significant determinant of long-term survival. Lower-third lesions also demonstrated a survival advantage. Irrespective of tumor histology or tumor location, tumor resection always afforded longer survival times than did palliative treatments. A prognostic classification system based on weighted values of significant variables is presented that accurately predicted long-term survival. In conclusion, bile duct tumors in general are incurable, except perhaps for a small subset of patients with papillary adenocarcinoma.
Papillary histology is the most significant determinant of ultimate survival and cure.
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