Moose, wolves, lynx, wolverine, black and grizzly bear range throughout the refuge. A series of bluffs, The Palisades, near the northeast boundary of the refuge, has evidence of Pleistocene animals and plants endemic to the area at that time. Wildlife observation, hunting, fishing, camping and boating are permitted on the refuge. The Nowitna River is a Class I river with no white water making it favorable for float trips. Water levels and current can vary drastically depending on snowmelt and rainstorms.
Mosquitoes can be intense and adequate repellent and headnets are necessary.
Contact the refuge for suggestions and precautions for traveling on the refuge and for permitted air charters. Ruby, the closest village to the refuge, has lodging and groceries.