The rash may be confined to the groin area or be more generalized. Other reactions can include acute nonthrombocytopenic purpura, leukopenia, petechiae, ecchymosis, eosinophilia, peripheral edema, adenopathy, fever, and fixed drug eruption, with cross-reaction to carisoprodol. More serious hypersensitivity reactions are rare. Also, anaphylaxis, erythema multiforme, exfoliative dermatitis, stomatitis, proctitis, Stevens-Johnson syndrome, and bullous dermatitis. If any allergic or idiosyncratic reaction develops, meprobamate therapy should be withdrawn and appropriate symptomatic therapy instigated.
Patients can develop physical or psychological dependence while on meprobamate.
After prolonged use, symptoms of ataxia, dysarthria, and vertigo may develop. Sudden withdrawal of meprobamate can produce withdrawal symptoms including vomiting, ataxia, tremors, muscle twitching, confusion, hallucinations, and occasionally seizures. Pre-existing symptoms such as anxiety, anorexia, or insomnia may also emerge. Withdrawal symptoms occur within 12 -48 hours of discontinuation of therapy. After prolonged use of meprobamate, dosage should be gradually reduced over a period of one to two weeks to minimize withdrawal symptoms.