The primary goal of treatment is to prevent or treat gastric ulceration, renal failure, CNS effects, and possibly hepatic effects. Prognosis is good if animal is treated promptly and appropriately. Delay in treatment can decrease survival potential with large exposures. Stabilization Assisted ventilation and supplemental oxygen may be required if the animal is comatose. Acid base imbalances should be corrected.
Metabolic acidosis is treated with slow IV infusion of sodium bicarbonate in fluids.
Bicarbonate and fluid therapy must be monitored closely via blood gases and adjusted if pulmonary edema or metabolic alkalosis develops. Decontamination procedures with ibuprofen are similar to those described for acetaminophen toxicoses. Activated charcoal adsorbs ibuprofen and should be repeated, since ibuprofen undergoes enterohepatic recirculation. Forced diuresis, dialysis or hemoperfusion does not enhance ibuprofen elimination. 14 Peritoneal dialysis may be necessary if unresponsive oliguric or anuric renal failure develops.