Identification and characterisation of novel tumor-associated antigens. The molecular basis for the determination of the finite mitotic potential of normal mammalian cells is not known. Research in the group is aimed at using a variety of molecular procedures to identify the underlying mechanisms that regulate the finite mitotic lifespan and how they are overridden when cells undergo immortalization. Investigating signal transduction and growth regulation using Drosophila genetics, cell biology and biochemistry. A common aspect of tumour formation is deregulation of normal cell-cycle controls.
Normal cells are subject to both positive and negative growth stimuli.
These are finely balanced during development and adulthood to ensure growth or homeostasis when appropriate. Tumour cells have acquired genetic changes, which disturb this balance resulting in inappropriate growth. We are interested in the molecular mechanisms underlying the regulation of cell proliferation and how these controls are lost during tumour formation. Our work is directed at understanding the cellular and molecular mechanisms that mediate virus entry and assembly. The fact that these viruses are membrane containing viruses and that their entry and assembly must involve interaction with cellular membrane systems means that we can also use these viruses, or their components, to investigate basic properties of cellular membrane systems.