Resistance is based on cephalosporinase production. Methicillin-resistant Staphylococci are also usually resistant to the cephalosporins. Toxicity Very irritating substance. Large or repeated IM doses may produce severe pain, local induration, and occasional sterile abcesses. IV administration especially in infants may cause thrombophlebitis.
Recent data suggest increased nephrotoxicity when used with an aminoglycoside.
References McCracken and Nelson, Antimicrobial Therapy for Newborns, 2nd Edition, p. 33, 1983.