As a research tool for understanding the role of the minK gene product in integrated organ function and in a variety of tissues including heart, uterus, kidney, inner ear, submandibular gland and brain. Evaluation of pharmacologic therapies for a wide range of diseases. As a research tool for investigators requiring an easy visualization of cells of the murine cardiac conduction system. The role of the minK gene in integrated physiology is unknown, so this mouse can be an important tool in elucidating that role. The lacZ reporter gene, as controlled by minK regulatory elements, can be used as a convenient marker for cells of the developing and the adult conduction system in the murine heart.
Mice are available.