Loeppky JA, Icenogle M, Scotto P, Robergs R, Hinghofer-Szalkay H, Roach RC Ventilation during simulated altitude, normobaric hypoxia and normoxic hypobaria Respiration Physiol. VE was increased similarly by altitude and normobaric hypoxia. The greater VE during the first hour at altitude, relative to subsequent measurements, may be related to the appearance of microbubbles in the pulmonary circulation acting to transiently worsen matching.
Results indicate that hypobaria per se effects ventilation under altitude conditions.