So, no matter how tempting, only use one address. You will still get spam, but only one copy of it. Unfortunately, once you start getting it, you are going to keep getting it. But, some things can help get you off of some mailing lists. When you receive any unsolicited commercial e-mail, forward a copy to the web host.
Most service providers have a dim view of spam.
After most spammers get their accounts taken away by several service providers - they get the message and quit spamming. A lot of spam comes from MLMers. You have all received the same e-mails. Just in pre-launch, this will explode. It may take some trouble on your part to find out who is really in charge of the company.