Our research focuses on the role of growth factors such as IGF-I and NGF on neuronal survival and on potentiation of axonal growth and myelination. Using models of diabetic neuropathy, we find that high glucose induces processes intrinsic to programmed cell, such as mitochondrial enlargement, depolarization, and activation of specific caspase cleavage products. I induced signaling pathways involved in these processes. This research will help to better understand the molecular processes controlling myelination and remyelination in the peripheral and central nervous system.
Neurons undergo apoptosis in animal and cell culture models of diabetes.
I prevents apoptosis in sympathetic neurons exposed to high glucose. For site credits, questions, or comments click here for the webmaster .