Must go through blinded first. Patient must have non-malignant, chronic pain with a daily intake of at least 45 mg morphine equivalents. Patients must be titrated to comfort within 21 days. Patient keeps a diary throughout study. Labs and physicals at screening and termination visits only.
Patients are eligible for open label immediately upon completion of randomization.
They receive a Morphelan dose equal to daily dose MSContin attained during stabilization. Morphelan is taken once daily, in the morning. Open label is available for up to one year after entry. Monthly visits are required with interim visits for titration as needed. Labs and physicals completed every two months.