In the rabies infested developing countries modern cell culture vaccines are hardly affordable. Dangerous neural tissue derived vaccines are still used. There is a critical shortage of human and purified equine rabies immunoglobulins, which are essential biologicals in the treatment of severe exposures. When analysing the treatment failures reported in the literature and in our internal files, we could identify the essential mistakes in rabies post-exposure treatment. Rabies is continuing to expand its range worldwide.
New regions are affected, new vectors become important.
Effective vaccines and economic regimens are available. But shortage in immunoglobulins and treatment mistakes result in normally preventable human deaths. Since 1982 a whole battery of trials was carried out with Rabipur in Croatia focusing on the immunological parameters of the vaccine. Tolerance Rabipur has proven to be well tolerated by the vaccinees, causing none or only transient local symptoms of a mild nature at the injection site. They resolved spontaneously .