In the majority of children with the DiGeorge anomaly, the lymphocytes eventually learn, and these children eventually develop, normal immune system functioning, but much slower than in children without the DiGeorge anomaly. In the meantime, they are susceptible to fatal infections. Avoid all live-virus vaccines in these children and their close contacts. When infections are detected, they should be treated promptly. Basic issues, such as adequate sleep, good nutrition, and frequent hand-washing, are of heightened importance to children with the DiGeorge anomaly to give their immune systems the best footing possible.
Multivitamins are a good idea.
So too are acidophilus and lactobacillus. I recommend live, active-culture yogurt. Herbal supplements, such as echinacea and goldenseal, may be of some benefit, although this remains unproven. Like most conditions, the DiGeorge anomaly comes in varying degrees of severity. Interestingly, the very defect that renders these children's lymphocytes ineffective also makes these children less likely to reject a transplant.