Some theologians divide sin into sins of commission and sins of omission. A sin of commission is the harmful consequence of an action. A sin of omission is the harmful consequence of a failure to act. Antiviral monotherapy could also be another example of a sin of commission. A sin of omission could be a metaphor for the failure to initiate the most effective combination antiviral regimen or to fund such a regimen for the poor.
Original sin offers another series of related metaphors.
In the Biblical myth, it was Eve who infected Adam by her disobedience of God's dictum, the punishment for which was the loss of unity with God and the natural order, a loss that was transmitted through Eve to their offspring in perpetuity. However, in HIV disease it is usually Adam who infects Eve who in turn transmits the infection to their child. Such anthropomorphic statements seem to better illuminate the nature of humanity than the nature of God. Here is where the metaphor of sin gains some weight. A Christian epistemological construct asserts that sin against the Infinite can be eradicated only by Infinite reparation, ie, Christ's death as the Infinite reparation for Adam and Eve's sin against the Infinite.