This does not occur in all rats and also does not result in complete prostate destruction. He believes that there is ignorance of this protein. One can get prostatitis if express PSBP at abnormal place and time. PSBP is not found in humans. Prostates are different from one species to another.
Organs involved in reproduction are under higher selective pressure and therefore quite different.
They used subtractive hybridization and microarray to get prostate tumor specific and prostate specific genes. EF5 is taken up by hypoxic cells and stainable with antibodies. He discussed IFN- dependent tumor immune surveillance. He believes that this is due to T-cell response problems. The ability of IFN gamma to induce unresponsiveness of SCK cells involves IP10 and MIG production by tumor and blood vessels.