Double-stranded RNA Genome 1. Rotaviruses contain 11 double stranded RNA segments. Rotaviruses can be classified by their dsRNA patterns or electropherotypes. During co-infection, Rotaviruses within Groups are able to exchange or reassort RNA segments. Rotavirus Infection 1.
Rotaviruses infect the villous tip epithelium of the proximal small intestine.
Rotaviruses are the leading of cause severe dehydrating diarrhea in infants and young children and contribute to some adult diarrheal disease. Neonates less than 1 month of age often exhibit minimal symptoms of rotavirus infection resulting from maternal antibodies. Diet and nutrition, breast feeding, intestinal flora and age may all participate in host resistance. Rotavirus Transmission 1. Rotaviruses are transmitted via the fecal-oral route.