Immune suppressants such as cyclophosphamide or azathioprine are used aggressively to reduce immune system effects. It is fairly effective in slowing or reversing the disorder. Dialysis may be required if kidney function is poor. Kidney transplant may be quite successful, especially if performed after circulating antibodies have been absent for several months. The probable outcome is variable.
Most cases progress to severe renal failure and end-stage renal disease within months.
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