We study signal transduction, the molecular mechanism by which cells respond to extracellular signals. The types of signals that we study regulate many cellular processes in neuronal and non-neuronal cells but our particular focus is on regulation of survival and differentiation in neurons. Neurons exist in complex environments in which they constantly receive many diverse types of signals. One question is how neurons integrate multiple signals, coming from different sources, and make an appropriate response. Like all cells, neurons respond to various extracellular stimuli that signal via plasma membrane receptors.
Neurons are special in that they are also electrically active.
Nerve membrane electrical activity, like signaling through plasma membrane receptors, is an important regulator of neuronal survival and differentiation. A second question is how nerve membrane electrical activity can control intracellular events. Both the presynaptic and the postsynaptic target provide trophic support to SGNs and both are necessary. Either cutting the central projection or eliminating hair cell results in SGN death. Thus, the spiral ganglion is a simple system that exhibits integration of trophic signals from two distinct and well-defined sources.