The game takes place in the Land of the Dead, which is the place we go to after we die. You are Manuel Manny Calavera - travel agent for the Department of Death. Your job is to pick up the recently deceased in the land of the living, take them to your office and try to sell them the best travel-package they qualify for. If they have been really bad, however, they only qualify for postage in a coffin with lots of combustible packing material. Manny is one of those people who wasn't very good when he was alive, and so he has to work some community service at the DoD to pay for his way out.
Problem is, Manny doesn t seem to get good clients any longer.
Since the new boss, Don Copal, arrived, all the clients Manny gets are lowlives who qualify for a walking stick at best - and without any premium sales, Manny will never get out. The game starts with a very nice intro to Manny, his job and a guy named Celso Flores who has just died. Apparently there has been a mass-poisoning and, owing to the short notice, all clients are up for grabs. This could be the break Manny has been waiting for. When Manny gets down to the garage he discovers that his driver has been sent home for the day by his number one competitor, Domino Hurley, and without transportation, there s no way to reach the poisoning site.