In each case, there was substantial cost saving compared with surveillance alone for each year saved and for each quality-adjusted year saved. Dr Grann and his colleagues concluded that chemoprevention improved quality-adjusted survival much more than did prophylactic surgery, and at little cost or significant savings compared with surveillance alone. . . . . . . . The modified statistical model used effectively predicted BRCA1 or BRCA2 status, but not tumor relapse. . . . . . . . Radiation had no adverse effects following conservative surgery patients positive for either BRCA1 or BRCA2. Prior evidence had suggested that BRCA1 or BRCA2 proteins may interact with a protein product of Rad 51, a DNA double-strand break repair gene.
Radiation is one of the causes of double-strand break.
They concluded that at the five-year point, there was no evidence of increased radiation sensitivity or sequelae in breast tissue heterozygous for a BRCA1 or BRCA2 germline mutation. Thus, there is no reason to avoid radiation in this population because of presumed toxicity consequences. Disclaimer Copyright , New South Wales Breast Cancer Institute.