While some specimens will show giant melanosomes, this is by no means diagnostic. Giant melanosomes can also be found in CALMs of patients with neurofibromatosis and in normal patients. Address metabolic acidosis with correction of underlying endocrine disorder and supportive care. The need for excision of hyperfunctional endocrine tissue is directed by the severity of the patient's endocrine imbalance and the efficacy of medical treatment. Endocrinology consult is indicated, as endocrine defects may be multiple and require careful orchestration of treatment.
Orthopedic consultation is indicated for pathologic fractures.
A variety of medications may be required to correct various endocrine and metabolic derangements. Some of these include medroxyprogesterone acetate, testolactone, bromocriptine, propylthiouracil, ergocalciferol, and calcitonin. Therapy should be conducted by a qualified endocrinologist. Typically does not stop acute bleeding episode but produces normal bleeding episode following withdrawal. Some agents have dopaminergic properties, which inhibit prolactin secretion.