The endocrine system has slow onset, widespread and often long- term effects on behaviour and physical growth. This contrasts with the rapid, specific response of the neural system. The distance to target tissue differs substantially for the two systems, that is, across the synaptic cleft for neurotransmitters vs. the entire circulatory system for hormones. Neurohormones are produced like neurotransmitters and released into circulation. They play an important role as releasing factors in the communication between endocrine and nervous systems.
Negative feedback is an important process for regulating the secretion and release of hormones.