BEH-People Ioannis Yannas Rm. Nerve Injuries to the peripheral nervous system result in partial or total paralysis of the affected tissues if untreated, resulting in a significant quality of life deficit.
Nerve injuries are a result of trauma, disease, and certain surgical procedures.
Current clinical treatments have led to incomplete and unsatisfactory recovery of motor and sensory function. The long-term goal of the current study is to develop a resorbable collagen device that results in regeneration that meets or exceeds the current clinical standards. Collagen and silicone tubes, implanted either empty or filled with the CG matrix, were used to bridge 10-mm gap injuries in the rat sciatic nerve. A sciatic nerve autograft was performed as a control for comparison with the current clinical method. Histomorphometry and electrophysiology were used to evaluate the regenerates.