Kidney is intact and undamaged. Swelling and necrosis of cells with sloughing into tubules common Interstitium - edema with minimal cellular infiltrate Correlation of pathologic appearance kidney and clinical course is poor Cells in the proximal straight tubule and the medullary thick ascending limb may be the only cells damaged Pathophysiology of decreased GFR and severe prolonged oliguria in acute renal failure. It is well established that during ARF the kidney is vasoconstricted. The vasoconstrictors are activated by sympathic nervous stimulation, ischemic cell damage or increased sodium chloride delivery to the macula densa Glomeruli may also undergo vasoconstriction secondary to angiotensin II thromboxane and endothelin thus shutting off small capillary loops. Lowest in obstetrical patients.
Medical patients intermediate.