The choice of dose within the recommended range will vary with the patient and the clinical situation.
Pharmacokinetic data show that there is an increase in the duration of action with increasing dose.
24 Foxhounds divided into 3 groups of 8 dogs each. The two solutions are similar with the exception of the absolute molecular weight distribution. They are both based on an ultra-purified, glutaraldehyde polymerized, bovine hemoglobin in a modified Lactated Ringers buffer. The processing steps are similar with the exception of a final filtration step for HBOC-201 to remove low molecular weight hemoglobin. 3 weeks prior to treatment and the RBCs were stored.