In addition to proposals on the test method, IRAG presented a system for the scoring and evaluation of test results and classifications of test materials for product hazard labeling purposes. It uses responses of the cornea, scoring times after administration of a test substance. When at least two treated animals are designated as having positive responses, the test is positive. Positive test materials are designated as either irritants or severe irritants. The steps taken by IRAG attempt to move the three US regulatory agencies toward unity.
Responsibility now rests on the agencies in developing a singular regulatory position.
To the extent the final position goes beyond those established by OECD, the United States will work for broader harmonization. In regard to scoring, evaluation and classification, there still remain substantial differences between what was proposed and what is used by other authorities and especially the member nations of the European Economic Community. There are several international efforts working to harmonize hazard classification and labeling systems, and it is hoped that there can be significant progress there as well. All rights reserved.