In the present study, we examined the expression of CD44 mRNA in 20 acute myelocytic leukemias by semiquantitative RT-PCR analysis and assessed its prognostic value. CD44v6 was expressed in 11 cases, although its levels and those of other variants containing exon v7 through to v10 were much lower than those of CD44H. Isoforms containing exon v4 or v5 could not be detected. On the other hand, the intense expression of CD44H did not correlate with the prognosis of leukemia. CD44v6 thus appears to be a marker for the poor prognosis of acute myelocytic leukemia. The accurate detection of this chromosomal rearrangement is vital due to its association with a favorable prognosis.
Recent studies reveal that resveratrol can inhibit each step of multistage carcinogenesis.
However, the molecular mechanisms underlying anti-tumorigenic or chemopreventive activities of this phytochemical remain largely unknown. The growth inhibitory and antiproliferative properties of resveratrol appear to be attributable to its induction of apoptotic cell death as determined by morphological and ultrastructural changes, internucleosomal DNA fragmentation, and increased proportion of the subdiploid cell population. These results, together with previous findings, suggest the cancer therapeutic as well as chemopreventive potential of resveratrol. Poludnenko LY TI - Acute leukemias in children from the city of Kiev and Kiev region after the Chernobyl NPP catastrophe. The criteria of an FAB classification supplemented by immunophenotyping data were applied.