Abdominal Pain Abdominal pain can have a variety of causes.
Most abdominal discomfort is related to the digestive system.
But it can also be related to cardiovascular system, musculoskeletal system, urinary system, and the reproductive system. You have constant or increasing upper or lower abdominal pain with nausea and significantly decreased or loss of appetite. You have constant or increasing upper or lower abdominal pain with increasing nausea and vomiting. You have increasing upper or lower abdominal pain with movement such as walking or driving on a bumpy road. You have abdominal pain with rectal bleeding.