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Psoriasis is a common condition which, at times, can be difficult to treat.
Patients with psoriasis face many social challenges and can suffer a great deal with their disease. As a result, any new topical agent is a welcomed addition to our therapeutic armamentarium. We present here a report of a case using a novel topical preparation of zinc pyrithione for the treatment of psoriasis. Topical zinc pyrithione appears to be a safe and effective treatment for psoriasis. The clinical course is dynamic, capricious, and replete with flares and remissions.