In 1919, it was shown that peritoneum heals differently from skin. If you scrape your knee, healing occurs from the outside edges. Gradually, the raw spot in the center becomes smaller as the skin regenerates. In the peritoneum, islands of regenerated peritoneum occur over the entire surface at once. This means that large peritoneal wounds heal as quickly as small ones.
Most investigators agree that regeneration is complete within three to eight days.
Inflammation Inflammation is an integral part of post-surgical repair. A major challenge in identifying drugs and physical barriers is the requirement that they do not further inflame an already inflamed area. How Adhesions Are Formed Typically, adhesions begin with a fibrin matrix that occurs during coagulation. By four days post-injury, most of the fibrin is gone and more fibroblasts and collagen are present. Through days five through ten, fibroblasts align within the adhesion.