Our laboratory is interested in defining the biological functions of matrix degrading proteinases. We have previously focused on their role in tissue destructive diseases, primarily emphysema. With respect to emphysema, we now know the potential proteinases and we are studying the mechanism of inflammatory cell recruitment and alveolar development and repair. As for physiological functions of proteinases, we found that macrophage and neutrophil elastase both have distinct antimicrobial properties. Unlike other MMPs, macrophage elastase also inhibits tumor growth.
Mice lacking neutrophil elastase reveal impaired host defense against gram negative pathogens.
Requirement for macrophage elastase for cigarette smoke-induced emphysema in mice. Hydrolysis of a broad spectrum of extracellular matrix proteins by human macrophage elastase. Please send comments about this site to the web development staff .