Prognosis is excellent and therapy is usually directed towards cosmetic improvement.
Although the precise etiology of trichofolliculoma is uncertain, these tumors are not associated with systemic disease or other skin disorders. Trichofolliculomas are believed to represent abortive differentiation of pluripotent skin cells towards hair follicles. In reported cases, trichofolliculomas demonstrate no definitive race predilection. A tuft of white hair may be present emerging from the central pore. Rarely, a prior history of trauma at the tumor site is obtained.