Lisa Frenkel MD Children have frequently been treated with antiretroviral combinations that are insufficiently potent to suppress the virus, leading to resistance. This leading US paediatrician treats with more complex therapy upfront as well as in a salvage setting. In particular, treatment has 'failed' those children who developed resistance to combinations that were insufficiently potent to maximally suppress the virus. Our aim is therefore to determine regimens that suppress viral replication, minimise side effects and that are practical for a child's lifestyle.
Paediatric care is based on limited data.
Nevertheless we have some data to work with. Subsequently, studies were designed to evaluate the suppression of viral replication, instead of clinical outcomes. While the data examining these issues is meagre, it does not support these suppositions, and they have not been reflected in adult care. Salvage therapy Salvage therapy has been less well studied but adult care has produced several important general lessons, including the importance of early switching and using greater numbers of accurately targeted agents. Nevertheless, the efficacy of salvage therapy has generally been inferior to the initial therapy of untreated individuals in all studies.