Jitter testing with single fiber EMG may be more sensitive than repetitive stimulation. CT scan of the chest looking for thymoma should be performed in all once the diagnosis has been made. Symptomatic treatment usually consists of giving anticholinesterase drugs. Most patients require 120 mg orally every 4-5 hours. If nicotinic side effects develop, reduce the dosage.
Plasmapheresis is also very helpful when there are acute exacerbations.
Prednisone treatment is recommended by some. These drugs may take 6-12 months to work.