This time he's not pulling any punches, and he's even tougher to beat despite the lack of one of his eyes. He can attack with fire and eye beam attack in addition to his devastating melee attacks. Even worse, he often takes to the air and attacks from above, making him harder to hit. Start off by nailing the sucker with a Blunderbuss, then running for meta essence. After the Blunderbuss, use the Jacks o' Death and the Jabberwock Eye Staff combination against this monstrosity, and remember to keep moving.
Meta essence is scarce here, so make every bit count.
Avoid attacking the Jabberwock while he's in the air, and instead run from his fire attacks. When he's on the ground, hit him hard. Once you injure him enough, he won't be able to fly any more. It's tough, but it's definitely possible. Once you're done, say goodbye to Griffon and go through the Castle gates.