The old Empire has collapsed. The players, as Space Lords, are attempting to reunify the galaxy once again. Their goal is the conquest of the planet Saestor, the capital of the old empire. Amoeba Wars is the game of the attempt by the Space Lords to conquer Saestor and establish the new Empire. Each player starts on their home world with a small fleet of ships.
Players expand to conquer other solar systems.
An unoccupied solar system can be conquered easily, systems containing ships belonging to other Space Lords or systems containing Space Amoebas are more difficult. In the mean time, the other players are attempting to do the same thing. The Amoebas are spreading into the galaxy on their own and the two Doomsday Machines left by the old Empire are randomly moving around the galaxy leaving a trail of destruction. The more solar systems the player controls the more ships they can produce. Eventually, one player can build up a large enough fleet to attack Saestor and defeat the Amoebas there.