Hemolytic anemia is frequently associated with cold agglutinins and depends on the ability of the cold antibodies to initiate activation of the complement pathway on the red cell membrane. The hematocrit and MCHC may also be erroneous since they are dependent upon accurate red cell counts and MCV's. Warming the blood and diluent to 37 C before performing the analysis may reverse the agglutination. Cornbleet J. Spurious results from automated hematology cell counters. Autoimmune hemolytic anemias.
Osteoblasts are normal cells that are involved in bone formation.
They are sometimes present in aspirates of bone marrow or touch preparations of trephine biopsies from bone marrow. They are large cells with round or oval nuclei, one or more nuclei and abundant blue-gray cytoplasm. A prominent clear zone or hof of Golgi is often present in the cytoplasm. Osteoblasts may be difficult to differentiate from plasma cells, but plasma cells are usually smaller, the nuclear chromatin pattern more condensed, and the cytoplasm a deeper blue. Osteoclasts are very large cells with multiple, seperate round to oval, uniformly sized nuclei.