Pretreatment with antihistamines 50mg IM l hr. Reaction is not related to iodine. Atopics allergic to shellfish have a slightly increased risk. Low osmolality contrast media has decreased reactions with increased patient comfort. Modulators of Arachidonic acid metabolism.
Reactions are secondary to increases in by products of lipooxygenase pathway.
Bisulfites which are used as sanitizing agents for food containers and fermentations equipment. FDA allows in non-thiamine containing foods. Sprayed on fresh vegetables, shellfish, beer, and wine. Ingest 20-100 mg per restaurant meal. Also found in medications.