Objectives Identify common features of reversible protein-protein interactions.
Learn the basic elements of the heat shock response. List the major classes of molecular chaperones and identify their cellular roles. Compare the mechanism of regulated binding of unfolded proteins by Hsp70 and Hsp60. Consider the involvement of molecular chaperones in disease, immunology and tissue repair. For comparison, the Kd for dissociation of a multisubunit enzyme may be in the picomolar to nanomolar range.