Nerve conduction velocity, as well as sodium-potassium ATPase activity, improved using the fish oil treatment. A preventive effect of fish oil was observed on nerve histological damage. An indicator of normal myelin fiber structure was absent in the olive oil group and was restored in the fish oil group. The Mayo Clinic also reported the role of oxidative stress in research disclosed in Diabetes Journal, September of 1997. The results of the study suggested the efficacy of antioxidants for the treatment of diabetic neuropathy.
Oxidative stress is present in the diabetic state.
Antioxidant enzymes are reduced in peripheral nerves and are further reduced in diabetic nerves. Alpha-lipoic acid is a potent antioxidant that prevents lipid peroxidation in vitro and in vivo. Alpha-lipoic acid has been shown to prevent deficits in nerve conduction and nerve blood flow. Also, alpha-lipoic acid restores reduced glutathione levels in nerves, and reduces lipid peroxidation. Scientists believe that alpha-lipoic acid is potentially beneficial for human diabetic sensory neuropathy.