We study the purified gene products of the vertebrate retinal rod. We are especially interested in those protein ensembles and processes which can help us to understand the visual excitation and adaptation processes as observed in the intact photoreceptor cell.
Rods accomplish the functions of visual excitation and light adaptation with remarkable panache.
The ROS exhibits a photon driven reduction in its transmembrane current. This light-dependent hyperpolarization of the ROS membrane is called visual excitation, which manifests as progressive desensitization to light. Red cells deteriorate dramatically when stored in the refrigerator. We have studied this refrigeration-induced 'storage lesion' and have come to understand some of its molecular mechanisms. This has permitted us to devise new and more effective ways to store red cells for longer time periods with less deterioration.