Patients may present with seizure disorders, mild to moderate developmental delay and mental retardation. A gray matter lined parenchymal cleft develops which extends from the subarachnoid space to the subependyma of the lateral ventricles. The clefts can be unilateral or bilateral. Polymicrogyria, microcephaly, and gray matter heterotopia have also been noted.
Prognosis is poor, with severe intellectual impairment, spastic tetraplegia and blindness.
Miscellaneous Most brain malformation can be produced by a variety of injuries during gestation. This includes infections, X-radiation, certain drugs, metabolic and genetic abnormalities. Imaging CT or MRI DDX 1. Pseudoporencephaly due to trauma, vascular, or infectious insults, which are almost always unilateral. Cystic tumor 3.