The Jagged2 gene maps to chromosome 12 and is a candidate for the lgl and sm mutations. Defects in limb, craniofacial and thymic development in Jagged2 mutant mice. Plasticity of Drosophila Paired function. The Slug gene is not essential for mesoderm or neural crest development in mice. Exclusion of Jagged2 as a candidate for the legless gene.
Notch signaling pathway mediates hair cell development in mammalian cochlea.
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