The Mojave fringe-toed lizard occurs in desert regions of Inyo, San Bernardino, Los Angeles, and Riverside cos. Males primarily fed on ants and plant material in the mornings, whereas females and juveniles ate ants and other insects throughout the day. Eggs are probably buried in the sand.
Reproduction varies from year to year depending on the amount of rainfall.
Fine, loose, windblown sand is required. Shrubs or annual plants may be necessary for arthropods found in the diet. Diurnal, daily activity patterns are temperature-dependent. In the early spring and fall, lizards are active mid-day. From May to September, they move about in the mornings and late afternoons, but retreat underground when temperatures are high.