Nausea, cold sweat, irregular heart beat and increased heart rate can occur. Some regular users develop a rash around the nose and mouth with a distinctive bluish tinge. The drug has distinctive odor and the aroma of it will sometimes develop in a room when used. Headache can also be a sign of use, or occur after use, but this symptom dissipates as tolerance develops. There is a flushing of the face, neck, and upper body indicating increased blood flow.
Nasal irritation can also be a sign of use of isobutyl nitrites.
Nitrite poisoning can occur with repeated use and lead to anemia. Some fall unconscious but with fresh air and elevation of feet they can recover quickly. The brain and central nervous system contain a large amount of fatty substances known as lipids which absorb and store the volatile toxic chemicals. The effects of inhalants on an individual will vary in accordance with body size and weight and the amount of chemicals inhaled. Also, since inhalants may contain more than one of a number of toxic chemicals, the effects of multiple toxins on the body must be considered especially dangerous.