Instead, these essential RNAs collaborate with protein cofactors. The graduate student and postdoctoral colleagues in our lab are broadly interested in the chemistry and biochemistry of RNA and of RNA-protein interactions. O ur goal is to understand, in a fundamental way, the principles governing RNA structure, RNA-protein complexes, and RNA molecular evolution. In a second broad program, we are developing technology for detecting mutations in human genes. Figure shows differences in local nucleotide flexibility mapped by selective acylation of 2'-amine substituted tRNA Asp .
Red regions are flexible, while blue regions are conformationally restrained.
Copyright 1998-2001 by Kevin M. Weeks. All rights reserved.