Thus interaction of pyridine with NMDA metabolism can result a significant toxicological response in both liver and lung. Kim et al. Both Kim et al. Iba et al. During this study pyridine was given to the rabbits i.p.
Pyridine also enters to the body via inhalation and by the other routes.
Pyridine taken up by any route, i.e., inhalation, oral administration, absorption through the skin, and s.c. or i.p. Since both of these are substrates for P4502E1, it is rather difficult to conclude that CYP2E1 is induced in the lung upon treatment of rabbits with pyridine. Pyridine is readily absorbed by inhalation and is a constituent of tobacco and tobacco smoke. Thus induction of NDMA N -demethylase suggests that in the lung as in the liver, pyridine affects the metabolic activation of this nitrosamine and in turn formation of lung cancer. This work was supported in part by a grant from Middle East Technical University, Ankara, Turkey.