When the nerve is stimulated, it releases chemicals known as neuropeptides. The major drugs for migraines, which are based on ergot or sumatriptan, work because they block release of neuropeptides, he added. Triptans also cause the arteries to narrow. Although many experts believed that changes in blood flow to the head and brain are responsible for migraines, Pappagallo said he suspected the meninges were involved. Migraine, which affects up to three times as many women as men, can be debilitating.
Prevalence rates vary by country, but people of European descent are the most likely victims.
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