When a wound occurs, several changes take place to minimize blood loss. First, the blood vessel slows the flow of blood past the wound site. Next, platelets collect at the wound site to form a plug. Finally, fibrin clots form scabs to replace these temporary platelet plugs. The coagulation, or clotting, factors are necessary for fibrin clot formation.
Most coagulation defects result in a coagulation factor deficiency and increased bleeding.
Factor V Leiden produces an inherited disorder that is present in 4 to 6 percent of the population. In addition, their risk of thrombosis is higher if other risk factors are present than it is in normal patients with the same risk factors. The disorder is detected by laboratory testing. More research must be done to determine the best treatment for the disorder. This web site does not render medical advice or professional services.