In broadest terms our laboratory studies the molecular mechanisms mediating human autoimmune and autoinflammatory disease. In collaboration with academic and industrial partners we assay gene expression profiles using microarrays to define new effector and regulator genes, physiologic systems of dysfunction, as well as novel molecular-based classification schemes of human autoimmune and autoinflammatory disease.
Projects are diverse, which provides a highly stimulating and fertile intellectual environment.
We establish clinical correlates of the data though collaborations with local physicians and functional consequences in our inflammatory biology facility. This gene, denoted MEFV , is the only human gene identified to date that upon mutation will cause frank arthritis in humans. Joined OMRF Scientific Staff in 2000. The Gene for Familial Mediterranean Fever, MEFV, is Expressed in Early Leukocyte Development and is Regulated in Rsponse to Inflammatory Mediators. Blood 85, 3223-31.