All of these agents are available by prescription. In addition, the experimental drug tenofovir is available through an expanded access program and clinical trials. Non-nucleoside agents also block HIV reverse transcription, but they do so in a different way than nucleoside drugs. All of these drugs are available by prescription. These drugs work by blocking the action of protease, a protein made by HIV, which the virus must have to reproduce and infect new cells.
Protease inhibitors are the most active group of anti-HIV drugs discovered to date.
Clinical studies show that antiretroviral drugs, when used in combination, can benefit many persons with HIV disease. This beneficial effect may last several years or longer in some people. However, these drugs do not help everyone with HIV disease, and there remains uncertainty about how to make best use of the available agents. Like any form of treatment, decisions about antiretroviral therapy must fit your individual needs and expectations. You should discuss with your doctor any issues that may interfere with your ability to take these medications as prescribed.