One of the consequences of upregulating phase II enzymes is an increase in glutathione content and glutathione S-transferase activity. Phase II enzyme inducers are found in certain components of our diet. This suggests that one of the ways that one can minimize tissue oxidative stress and all its attendant problems is to increase our intake of dietary phase II enzyme inducers. One of the problems associated with oxidative stress is oxidant-mediated damage of DNA that can lead to mutations resulting in cancer formation. Intake of dietary phase II enzyme inducers as a means to prevent cancer formation is a very active area of research.
Oxidative stress can also lead to inflammatory states.
I suggest that dietary intake of phase II enzyme inducers may also ameliorate those conditions associated with a chronic inflammatory state. Bernhard H.J. Juurlink Copyright 1999-2000. All rights reserved.