Replication occurs in the cytoplasm within a mostly intact virion particle.
The capsid is icosahedral and is not enveloped. There are three capsid layers that are about 70nm in diameter. Rota is also responsible for almost 1 million childhood deaths each year, especially in developing countries. Infants under two years of age are the primary targets of rotavirus. As a result, absorptive surface area is lost and fluid leaves the body as diarrhea.