In general, it recognizes things of natural origin, uses them therapeutically, and expels portions that may not get used by the body. Unlike the synthetic progestins approved by the FDA that may increase your risk of breast cancer, natural progesterone protects against many of estrogen's lethal side effects and protects against osteoporosis better than estrogen. While estrogen protects against osteoporosis by preventing the loss of bone, progesterone can actually reverse the process by increasing bone density. Several prospective studies have shown a significantly higher incidence of breast cancer in progesterone-deficient women. One study, in which 1,083 women were examined, found that pre-menopausal women who were deficient in progesterone had a 5.4 times greater risk of breast cancer.
Progesterone deficiency can also be a cause of depression, irritability, mood swings, and insomnia.
If you use DHEA or other therapies to boost estrogen levels, then it is even more important for you to apply transdermal natural progesterone cream to your skin on a regular basis. Progesterone is absorbed through fat cells under the skin. It is, therefore, important to apply topical progesterone cream to different parts of your body every day to avoid saturating your fat cells, thereby inhibiting progesterone absorption. As with estrogen replacement therapy, it is important to have complete hormone blood tests on a regular basis to make sure you are getting enough progesterone to block estrogen's carcinogenic effects and to prevent bone loss. The most popular prescription estrogen drug in the United States is Premarin, which contains estrogens derived from the urine of pregnant mares.