Treatment of renal failure requires careful management of fluid and electrolyte balance. Because renal damage is often reversible, peritoneal dialysis or hemodialysis should be used in cases of renal failure. Doxycycline, 0.2 g orally once a week, significantly reduces the attack rate of leptospirosis. Leptospira vaccines are available for dogs, but they have limited efficacy. Dyspnea, oliguria, leukocytosis, and radiographic and electrocardiographic abnormalities have been associated with higher mortality.
Recovery is complete except for the rare occurrence of residual renal tubular dysfunction.