When manganese is chelated with the amino acids proline, histidine, and glutamic acid, it travels through the blood to the hypothalamus. The hypothalamus is the organ below the brain which is responsible for regulating many body functions, including temperature, appetite and sleep. The chelated manganese increases the natural thyrotropin-releasing hormone secreted by the hypothalamus. Melatonin Melatonin is produced in the body by the pineal gland in the brain. The pineal gland takes the serotonin and makes it into melatonin, but only during the night.
Norepinephrine is another neurotransmitter which assists in melatonin production.
It acts as a catalyst to melatonin production by stimulating cells in the pineal gland to begin making melatonin in the absence of light. Sometimes, for one reason or another, the body does not produce adequate amounts of melatonin for its needs. This can result in insomnia and depression, among other symptoms. The body's ability to synthesize melatonin may decrease with age. It is well-established that some mineral deficiencies can be linked to physical conditions including grey hair, baldness, asthma, eczema, psoriasis, epilepsy, diabetes, arthritis and mental illness.