In both forms, physical examination is negative except for petechiae, purpura, and mucosal bleeding, which may be minimal of extensive.
Peripheral blood is normal except for reduced platelet numbers.
Bone marrow examination usually reveals increased numbers of megakaryocytes in an otherwise normal marrow. In the patient who responds, the platelet count will rise to normal within 2 to at most 6 wk. The corticosteroid dosage is then gradually tapered. Unfortunately, most patients either fail to respond adequately initially or relapse as the adrenal steroid is tapered. The patient with ITP and life-threatening bleeding should also be given patelet concentrates.