Similar to the other genera belonging to the phylum Zygomycota, treatment of Mucor infections remains difficult. Due to its property to invade vascular tissues, infarction of the infected tissue is commmon and mortality rates are very high. Early diagnosis is crucial and surgical debridement or surgical resection, as well as antifungal therapy, are usually required. Amphotericin B is the most commonly used antifungal agent. Liposomal amphotericin B and other lipid-based amphotericin B formulations, such as amphotericin B colloidal dispersion have also been used in some cases with zygomycosis.
Response rates are unfortunately unsatisfactory.
Reversal of immunosupression is one of the most significant factors influencing the clinical outcome. There are also a few data on succesful use of fluconazole and terbinafine in treatment of zygomycosis, which require validation. Search Medline Nucleotides GenBank References 3. Abe, F., H. Shibuya, M. Tateyama, Y. Ommura, N. Azumi, and K. Kimura. Adam, R. D., G. Hunger, J. DiTomasso, and G. Comerci, Jr. 1994.