The intestine is also a common site of pathologic processes. For example, the intestine is probably the site of origin of multiorgan failure leading to irreversible shock. In addition, the intestine is a model system because it has interacting muscular, endocrine, neural and cardiovascular components that have both local and systemic effects. I am interested in determining the regulatory mechanisms that control gut function, especially salt and water absorption, and the disturbances that lead to pathologic states. My current research interests revolve around the intestine and nitric oxide.
Nitric oxide is a major regulatory agent in the body.
It is a vasodilator that controls blood flow, is a neurotransmitter and is cytotoxic toward bacteria and parasites. In addition, nitric oxide has a protective role in shock. Grossie, B. V., Mailman, D. 1997. Influence of the Ward colon tumor on the host response to endotoxin. Klemm, K., Mercer, D.W., Mailman, D., Moody, F.G. 1997.