Companies such as Geron are develop unique approaches to aging control based upon intervention into the genetic mechanisms of aging, while doctors throughout the world are exploring the anti-aging potential of hormone replacement therapy. Even the doctors writing books on melatonin don't seem to be able to recommend the appropriate dosage level of melatonin for sleep. I've also heard that melatonin can slow down aging, but have no idea what dose of melatonin I should take for this purpose. Most life extensionist take 3 mg every night because of evidence suggesting that higher amounts of melatonin may be beneficial in enhancing immune function, pre- venting cancer, and slowing aging. For insomnia therapy, 3-10 mg of melatonin nightly usually works.
Many people now hold the melatonin under their tongue for more rapid assimilation into the brain.
People who wake up at night and can't get back to sleep often take another 3 mg. of melatonin under their tongue help them get to sleep again. On a number of occasions I've found that the recommended dose of a particular nutrient, drug, or hormone is not best for me. I've heard that I should be tested to determine how much of a substance to take, but I don't know what tests to undergo, where these tests are available, and how they should be evaluated. A Some people determine their intake of antioxidant nutrients based upon their weight. Those weighing less than 150 - 160 pounds take less than the recommended dosage, while those weighing more than 200 pounds take more than the recommended dosage.