No test is available for practicing physicians to diagnose mycoplasma or ureaplasma and the test for chlamydia is not dependable. The only dependable test for prostate infection is for your doctor to massage your prostate to collect secretions and immediately check your secretions for white blood cells. If he sees white blood cells in your secretions under the microscope, your urine has a positive leukocyte esterase or nitrite test and your urine culture and semen do not grow a germ, the odds are overwhelming that you are infected with chlamydia, mycoplasma or ureaplasma or something else that cannot be diagnosed. Failure to see white blood cells in your secretions does not rule out a prostate infection. Most urologists do not order semen cultures because they claim that they are always contaminated with germs from the skin.
Most men collect semen cultures from the vagina or mouth which always is contaminated.
One bacteria that is extremely difficult to cure is a group D enterococcus. It usually cannot be cured by taking oral medication. Sometimes it can be cured by injecting 2.4 million units of Bicillin several times a week for several weeks. Prostate infections are extraordinarily difficult to cure because antibiotics do not accumulate in high concentrations in the prostate. So most men have to take appropriate antibiotics for many months and their partners have to take the same antibiotics for a much shorter duration.