Cross-resistance may occur. Treat for 6-9 mo or until 6 mo have elapsed from conversion to sputum culture negativity. Pregnancy C - Safety for use during pregnancy has not been established. Impairs cell metabolism by inhibiting synthesis of one or more metabolites, which in turn causes cell death. No cross-resistance demonstrated.
Mycobacterial resistance is frequent with previous therapy.
Pregnancy B - Usually safe but benefits must outweigh the risks. However, resistant strains of M marinum have been reported. Several case reports have shown the effectiveness of this drug. Reports indicate that it can help eradicate an organism unresponsive to either anti-tuberculars or tetracyclines. Use of azithromycin has not been reported.