Acetaminophen works in the periphery as an analgesic but also has antipyretic effects. It is absorbed rapidly in the GI tract and is distributed to most tissue areas in the body. Acetaminophen inhibits the production of prostaglandin which then may cause irritation to the stomach. Hydrocodone is metabolized in the liver and excreted by the kidney. Hypersensitivity to hydrocodone or acetaminophen.
Narcotics tend to increase intracranial pressure.
Narcotics such as Vicodin may interfere with the diagnosis and treatment of patients with abdominal conditions. Use with caution in patients with liver, kidney disorder, underactive thyroid gland, Addison's disease, enlarged prostate or urethral stricture. The effects of Vicodin in pregnancy have not been established. Pregnant women must consult their physician before taking Vicodin. Drug dependence occurs in newborns when the mother has been taking this drug prior to delivery.