Not all patients respond, in which case sulfapyridine or sulfamethoxypyridazine can be tried. Retinoids - Decreases cohesiveness of abnormal hyperproliferative keratinocytes and may reduce potential for malignant degeneration. Modulate keratinocyte differentiation. Have been shown to reduce risk of skin cancer formation in renal transplant patients. Etretinate is main metabolite and has demonstrated clinical effects close to those seen with etretinate.
Mechanism of action is unknown.
Paraproteinemia, myeloma and intraepidermal IgA staining may develop several years after the initial presentation, and the exact nosological position of this rare condition is still controversial. Little is really known about its etiology or pathogenesis. Subcorneal pustular dermatosis. On the relationship between subcorneal pustular dermatosis and pustular psoriasis. Pyoderma gangrenosum and subcorneal pustular dermatosis, without monoclonal gammopathy.