Concomitant administration with rifampin may reduce serum chloramphenicol levels, presumably through hepatic enzyme induction. When taken concurrently, may increase the effect of anticoagulants. Serum hydantoin levels may be increased, possibly resulting in toxicity. In addition, chloramphenicol levels may be increased or decreased. Pregnancy C - Safety for use during pregnancy has not been established.
Precautions Use with caution in patients with impaired renal or hepatic function.
Serious and fatal blood dyscrasias such as aplastic anemia, hypoplastic anemia, thrombocytopenia and granulocytopenia can occur. Discontinue the drug upon appearance of reticulocytopenia, leukopenia, thrombocytopenia, anemia or any other findings attributable to chloramphenicol. Use in combination with chloramphenicol in penicillin-allergic patients. Clindamycin in combination with cefuroxime is an acceptable regimen for non-allergic patients. Interactions Clindamycin increases the duration of neuromuscular blockade, induced by tubocurarine and pancuronium.