ResearchIndex Home Waterman, M.S. and Vingron, M. 1994. Rapid and accurate estimates of statistical signicance for sequence data base searches . Waterman, M.S. and Vingron, M. 1994. Rapid and accurate estimates of statistical signicance for sequence data base searches . Most importantly, the statistics of normalized local alignment is poorly understood.
Normalization helps eliminate the mosaic and shadow effects.
Rapid and accurate estimates of statistical significance for sequence database searches , Proc. 5 gives an example of a Smith Waterman table. The residues are chosen independently according to the average amino acid distribution shown in Table 3.1. Rapid and accurate estimates of statistical significance for sequence database searches . For the case of gapped alignment, there is no theory which describes the distribution of alignment scores of random sequences.