Colima, Mexico Colima, Mexico Colima is the most active volcano in Mexico. Eruptions causing fatalities occurred in 1576 and 1818. The 1576 eruption caused great destruction of land and an unknown number of deaths. Deaths associated with the 1818 eruption may have been due to starvation and disease after the eruption. Colima has erupted at least 45 times since 1560, most recently in 1991.
Most eruptions generate pyroclastic flows.