Metal ions, such as copper, zinc, iron, and manganese, are integral, functional components of many enzymes and transcriptional regulatory proteins.
Metals are essential components of life, but are harmful when present in excess.
Increases in the levels of bioavailable toxic metals in the environment are, therefore, of great concern to human health. Engel and Freedman. The latter two researchers, together with Dr. McClellan-Green, are also involved in development of cell cultures for tests of effects of metals and other environmental pollutants. Dr. Richardson examines how ecological perturbations may enhance the methylation, and hence the bioavailability, of mercury. His studies complement those of Drs.