Unfortunately, these setbacks illustrate some of the difficulties in developing drugs, as animal studies sometimes do not predict what will happen in humans. What is urgently needed are combination studies of new therapies still in development for people who need third line regimens. Project Inform has been working with the Coalition for Salvage Therapy in advocating for just such studies. Table of Contents Mitochondrial Toxicity and Lactic Acidosis Mitochondrial toxicity and one of its symptoms called lactic acidosis have been highlighted recently as a previously undiagnosed side effect of anti-HIV drugs. Although much more research is needed to fully understand this issue, this article explores the current thoughts about the connections among mitochondrial toxicity , lactic acidosis and lipodystrophy.
Mitochondria are tiny rods found inside all human cells.
Several things can affect how well mitochondria work. As people age, get an infection or take certain anti-HIV drugs, changes can occur in mitochondria. These changes, or mutations, may damage the mitochondria and either disrupt the normal function of the cells or cause them to stop working altogether. Mitochondrial toxicity is a general term that refers to these changes. Perhaps more accurately, it is mitochondrial damage .