All participants in the substudy continued using 3TC in their regimens. The addition of the 184 mutation seems to increase HIV's sensitivity to adefovir, although the durability of this effect is unknown because of HIV's propensity to develop further compensating mutations. Choosing a drug based on the presence of specific resistance mutations is a novel concept, but as more is learned about the significance of genotyping, this may become a useful means for tailoring treatment regimens. Reproduced with permission. Inc. All rights reserved.
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