Notice that in contrast to adult fat, this tissue is intensely cellular. In addition, even at this power, one can appreciate that many of these nuclei are unusually large in size, such as the ones under the green pointers. The proliferating cell in this lesion is the lipoblast, two examples of which are pointed by the black arrows. These cells are round, contain a central nucleus and some evidence of fat accumulation. Tumor of adult life, with a peak incidence between 40 and 60 years of age.
Retroperitoneal tumors occur somewhat more frequently in women.
There is no evidence that any race or geographical area is more prone to develop liposarcomas. The three most common locations are the thigh, the retroperitoneum, and the inguinal region. Liposarcomas typically manifest a lobulated appearance. Cut section may reveal a mucinous appearance, especially if the myxoid component is prominent. Typically, at least some evidence of yellow color, due to the lipid material, is present.