Tumors are usually well-circumscribed, encapsulated and lobulated. The cut surface is variable depending on the histologic type. Tumors may resemble adipose tissue, may have a gelatinous appearance or may be fleshy and solid with variable areas of necrosis and hemorrhage. Well-differentiated liposarcomas closely resemble adipose tissue with varying degrees of atypical features. Round cell liposarcomas are cellular neoplasms with varying degrees of lipoblastic differentiation.
Pleomorphic liposarcomas are cellular neoplasms composed of pleomorphic tumor cells.
Liposarcomas present as mass lesions. The two most common sites are the extremities especially the thigh and the retroperitoneum. Recurrent lesions are not unusual. Robbins Pathologic Basis of Disease. Soft Tissue Tumors.