The disease involves the brain, heart, joints, and skin. It is uncommon in the U.S. except in people who have had untreated strep infections. It may occur in adults or children but is most common in children 5 to 15 years old.
Rheumatic fever is associated with the development of valve disease and other heart disorders.
There are also a grouping of minor criteria. Two major criteria, or one major and two minor criteria, are suggestive of rheumatic fever.