Many of these correlations have been defined largely through work in the MGH Molecular Neurooncology laboratory. Molecular genetic alterations in infiltrative astrocytic tumors . The genetic aberrations identified accumulate in a fixed percentage of tumors at each stage of malignancy. The proportion of tumors with mutations characteristic of less anaplastic tumors remains constant as anaplasticity increases. Thus, astrocytic tumors vary with respect to the subset of these mutations which are detected.
Neoplastic cells are clonal.
Neuroepithelial tumors of the adult brain. In Youmans JR, ed. W.B. Saunders Co., Philadelphia, pp. The new WHO classification of brain tumours. The World Health Organization classification of nervous system tumors in experimental neuro-oncology.