Research at the Centre has involved the development of new methods of measuring cough such as the measurement of cough sound pressure levels with a sound level meter and cough frequency with a computer based Maclab. One of the most important findings in our recent research has been that the standard cough medications, codeine and dextromethorphan, are no more effective than placebo treatment for cough associated with common cold. Much of the evidence for the antitussive activity of codeine and dextromethorphan comes from animal experiments and human studies involving chemically induced cough or cough associated with chronic respiratory disease. There is very little research on the effects of codeine and dextromethorphan on cough associated with common cold and our recent publications have stimulated a reassessment of the benefit of so-called 'active ingredients' in cough medications. Nasal congestion Measurement of nasal airflow by rhinomanometry.
Nasal congestion is a disturbing symptom associated with both nasal infection and allergy.
Our research has involved the development of standardised methods of quantifying nasal congestion by the measurement of unilateral nasal airflow using the technique of posterior rhinomanometry. The measurement of unilateral nasal airflow is necessary for studies on the so-called 'nasal cycle' which involves spontaneous and often reciprocal changes in nasal airflow over a few hours. Since nasal congestion is often unilateral it is important to measure the conductance of each side of the nose rather than measure total nasal airflow. Recent research has investigated the effects of decongestants on nasal airflow and the effects of nasal surgery on nasal airflow using a portable spirometer. Clinical trials Dr Jawad, Medical Director with a patient.