All of these disorders have both clinical and morphologic overlap and indeed hybrid forms are noted. This finding has enabled pathologists to diagnose and separate CML with accuracy from the other myeloproliferative disorders. In addition, the molecular events associated with this translocation have shed important information on oncogenesis.
Patients usually present with anemia, splenomegaly, and fatigue.
Spontaneous bleeding and lymphadenopathy may also be present. If there are high basophil counts, symptoms of hyperhistaminemia may occur. AFIP Press 1994.