Mitochondrial antibodies are negative.
No medications, history of hepatitis, or known malignancy. Review of outside material. The portal tract changes strongly suggest low grade biliary obstruction, such as with primary sclerosing cholangitis or a duct stricture. If clinically indicated, cholangiography should consequently be performed to clarify the presence and level of obstruction and establish the diagnosis. There is a mixed inflammatory infiltrate that includes patchy mononuclear cells together with numerous eosinophils and neutrophils.