Prolonged failure of adherence to daily biotin requirement will result in insidious onset of the underlying disease with potential life-threatening consequences. Early and consistent treatment will allow excellent prognosis. Teenaged patients often will rebel against taking daily medication despite the fact that biotin itself is odorless, tasteless, and given as a capsule. Multiple carboxylase defects and complementation studies with propionicacidemia in cultured fibroblasts. Medicine is a constantly changing science and not all therapies are clearly established.
New research changes drug and treatment therapies daily.
However, as medical science is constantly changing and human error is always possible , the authors, editors, and publisher or any other party involved with the publication of this article do not warrant the information in this article is accurate or complete, nor are they responsible for omissions or errors in the article or for the results of using this information. The reader should confirm the information in this article from other sources prior to use. In particular, all drug doses, indications, and contraindications should be confirmed in the package insert. Holocarboxylase Synthetase Deficiency Please email us with any comments you have on our new chapter format.