Each cycle of cell division leads to the synthesis of an equal amount of fresh molecules and results in a dilution of the damaged molecules in the heart of each daughter cell. Unfortunately, defense mechanisms are also submitted to the action of these deleterious substances and their activity declines during the aging process. Senescence therefore appears to be a consequence of the organism's progressive incapacity to manage glycoxidative stress. This schematized diagram of the biological mechanisms of senescence is in all likelihood very far from the complexity of the aging process. Nevertheless, it is important to understand that senescence is due from the upstart to molecular alteration.
Molecular lesions are responsible for both the dysfunction and the aging of cells.
Cellular aging induces in turn organic aging, systemic aging and finally that of the organism.