The following are some of the Center investigators' current research projects. Analysis of gene expression and asthma phenotypes.
Methodologic innovation involves extending the gene shaving approach to continous phenotypes.
Analysis of gene expression and DNA fingerprints for tuberculosis. Dr. Segal is PI of an NIH R01 award that focuses on developing statistical tools pertinent to the molecular epidemiology of tuberculosis. Methods for comparing fingerprints from differing strains have been devised, and methods for detecting gene deletions using expression data in concert with genomic location are being developed. New methods for phylogenetic regression are also being pursued as part of this grant. Analysis of peptide - MHC binding.