To see a video animation of this process, click here. To view a video animation of HIV replication, click here. Interactions with the host cell - insertional mutagenesis, transduction. Retroviral pathogenesis has concentrated on oncogenesis, but retroviruses also cause a variety of haematopoetic and neurological conditions. To date this is the only known instance of insertional mutagenesis of the human genome caused by this type of element, but other examples look certain to be discovered in future.
Retroviruses are under active development as vectors for gene therapy.
Tang, H. et al. Lentivirus Replication and Regulation.