Renal complications are rare. A Caucasian predominance has been reported. Typically, the disease process begins with a nonspecific upper respiratory tract infection. This usually is part of a 1-14 day prodrome during which fever, sore throat, chills, headache, and malaise may be present. Vomiting and diarrhea occasionally are noted as part of the prodrome.
Mucocutaneous lesions develop abruptly.
Clusters of outbreaks last from 2-4 weeks. The lesions typically are nonpruritic. Patients with GU involvement may complain of dysuria or an inability to void. A history of a previous outbreak of SJS or of erythema multiforme may be elicited. Recurrences may occur if the responsible agent is not eliminated or if the patient is reexposed.