Thus, when trying to identify possible homologues for a query sequence, it is best to use a variety of search tools. The following combination provides a comprehensive search strategy, any consensus between the results allowing a degree of confidence in a diagnosis. Initially, the protocol explores the primary sequence databases. A range of secondary database search tools is then offered. To allow retrieval of further information about a given sequence, pattern or structure, the relevant database query forms are provided.
Profiles are precise, but their numbers are limited.
Fingerprints are reliable and allow visual diagnosis. PDB - Search the PDB structure database by keyword. CATH - Search the CATH structure classification system with a known PDB code.