Obstetrical Hemorrhage 4. The following abnormalities of sexual differentiation are important for you to recognize. The first disorder of sexual differentiation is characterized by androgen insensitivity. View image Androgen Insensitivity. Patients have an XY chromosomal complement, lack of mullerian structures and a blind vaginal pouch and absence of sexual hair.
Mullerian structures are absent because the gonads secrete mullerian inhibiting substance.
The gonads may be located in the abdomen, inguinal canal, or labia. Routinely, orchiectomy is performed after puberty, to allow full pubertal development. Some of these patients show clitoral enlargement and labioscrotal fusion.