I am in Area Group I and in AIDS subgroup . My research interests are in sphingolipid biosynthesis and degradation. We have studied the regulation of sphingolipid by vitamin K in a bacterial system and in brain.
Patients accumulate a sphingolipid, glucocerebroside in the liver, spleen and bone marrow.
In our experiments, L-CS specifically inhibits the biosynthesis of cerebroside in young mice. HIV-1 cytopathic effect, replication and infectivity.