Urinary frequency, acute urinary retention, oliguria with hypertension, impotence, renal failure, azotemia, albuminuria, glycosuria, increased BUN, microscopic deposits in urine. Pulmonary hypersensitivity characterized by fever, dyspnea, pneumonitis, or pneumonia. Abnormal liver function tests, cholestatic or hepatocellular jaundice, hepatitis, acute intermittent porphyria. Calcium, thyroid function tests. Interference with some pregnancy tests.
Neuromuscular disturbances are the most common.
Tachycardia, hypo- or hypertension, conduction disorders, shock. Stomach should be irrigated completely even if more than 4 hr has elapsed following drug ingestion, especially if alcohol has been ingested. Respiration, ECG, BP, body temperature, pupillary reflexes, and kidney and bladder function should be monitored for several days. If significant bone marrow depression occurs, the drug should be discontinued and daily CBC, platelet and reticulocyte counts determined. Perform bone marrow aspiration and trephine biopsy immediately and repeat often enough to monitor recovery.