If intubation is required, use an endotracheal tube 0.5-1 sizes smaller than expected to minimize trauma in the inflamed subglottic area. Once the airway is stabilized, IV access should be obtained for initiation of antibiotics. If the patient has failed extubations in-spite of appropriate medical management or if intubation will be prolonged. This drug provides empiric therapy against etiologic agents, specifically penicillinase-producing strains of Staphylococcus. Pregnancy B - Usually safe but benefits must outweigh the risks.
Precautions Use with caution in patients with severe renal impairment.
Use with caution in patients with a history of hypersensitivities to cephalosporins. This drug provides empiric therapy especially against H. influenzae and modest activity against anaerobes. Do not exceed 2 g IV q24h. Avoid in patients with previous hearing loss. The neuromuscular blockade may be enhanced, when used concurrently, with nondepolarizing muscle relaxants.