Snyder's laboratory has pioneered many new chip technologies. His laboratory has recently invented new protein chip technologies for analyzing hundreds to thousands of proteins simultaneously. Protein chips are disposable arrays of microwells in silicone sheets placed on top of microscopic slides. Only small amounts of protein are required. In a study published in the November issue of Nature Genetics, Yale researchers overexpressed nearly all of the yeast protein kinase and analyzed them using 17 different substrates and protein chips.
Protein kinases are key regulatory molecules that control many biological processes.
They discovered many novel activities of the protein kinases that were not known previously. Our method takes advantage of genomics and all of the targets in one simple experiment.