There is no known hormonal or medical treatment effective in controlling progressive polyostotic fibrous dysplasia. Surgical procedures to correct fracture and deformity include grafting, pinning, and casting. Skull and jaw changes are often corrected surgically, with great improvement in appearance. Treatment and therapy for this bone disease is usually the most difficult aspect of caring for a child who has severe polyostotic fibrous dysplasia. In dark skinned individuals, these spots may be difficult to see.
Most children have the pigment from birth, and it almost never becomes more extensive.
The pattern of the pigment distribution is unique, often starting or ending abruptly at the midline on the abdomen in front or at the spine in back. Some adolescent children may want to use makeup to obscure areas of dark pigment on the face. So far, researchers have not found a cure for the bone and endocrine disease in McCune-Albright syndrome. It cannot yet be diagnosed before birth and there is no way to accurately predict how severe the disease may become in an affected child. There are no reported cases of any parent being affected, and the children of women with McCune-Albright syndrome are normal.