Please conduct a current literature search and check the appropriate current online database for the most recent quantitative information. Dermal contact, even with dilute solutions, has caused skin irritation and necrosis.
Propylene oxide is also a mild central nervous system depressant.
An increased incidence of inflammatory lesions of the nasal cavity, trachea, and lungs has been observed in rodents chronically exposed to propylene oxide by inhalation. Neurological effects have also been observed in rats and monkeys chronically exposed. No information is available on the reproductive or developmental effects of propylene oxide in humans. A study with rats and rabbits exposed to propylene oxide by inhalation prior to and during gestation concluded that propylene oxide was embryotoxic but did not cause birth defects. Increased resorptions per litter were observed in rabbits.