We conclude that an important reason for symptoms of asthma to develop is the characteristic inflammation causing a surfactant dysfunction. PLA2 originating from macrophages and PLB from eosinophiles. Another study angle will be to investigate if the concentration of the apoprotein SP-A is so low in the asthmatics that it will not fulfill its normal function of counteracting protein inhibition. B.A. Disruption of pulmonary surfactant s ability to maintain openness of a narrow tube. Surfactant dysfunction develops when the immunized guinea pig is challenged with ovalbumin aerosol.
Ozone affects breathing and pulmonary surfactant function in mice.