We also sponsored the founding of the Alabama Chapter of the NF Foundation. Type 1 or NF-1 or von Recklinghausen Disease or Peripheral Type is rather common. The frequency is about 1 in 3,000 persons. The clinical features are many and the gene mutation is on chromosome 17. The clinical features are quite different from NF-1.
Most symptoms reflect the presence of tumors in the spine or in the head.
Some types of tumors have a tendency to develop at a younger age . The most common tumor is acoustic neuroma. A person who develops bilateral acoustic neuroma should consider the possibility of having NF-2. The gene mutation is on chromosome 22. Presymptomatic diagnosis may be considered.