Histologically, degenerative changes in the hair follicles can be observed. This is a recessive trait. Hairless conditions are also caused by BVD or bluetongue virus. Collagenous tissues of the body exhibit fragmentation and disorganization of collagen fibers. Affected calves show delayed healing of skin wounds.
Minimal trauma gives rise to hematomas due to a deficiency of procollagen peptinase.
The most distinguishing factor involves the iris color. The pupil always appears constricted in daylight. From a distance the eyes appear white or silver. The fundus of the eye appears albinotic. The animal will show photophobia and may be prone to eye irritation.