Dr. Gruberg's laboratory has shown that nucleus isthmi is the sole cholinergic input to the tectum. Currently under physiological study is how nucleus isthmi affects elements in the tectum. Dr. Gruberg's laboratory is also studying mechanisms that enable frogs to distinguish between prey stimuli and threat stimuli. By manipulations of the optic nerve, the laboratory has been able to abolish behavioral responses to threat stimuli selectively, reversibly, and unilaterally while sparing behavioral responses to prey stimuli. Model for tectal influence of right nucleus isthmi.
Neurons are simple gating devices.