A specimen of this tree on the island of Kos, Greece, is reputed to be the Tree pf Hippocrates, the Father of Medicine. A seedling of this tree grown in Canada produced conjunctival and nasopharyngeal irritation in four workers from its leaf hairs. Edited and first printed A.D. 1933 by R.T. Gunther 1959. Poisonous Plants of the United States. Respiratory irritation by leaf hair of the tree Platanus.
Plane tree leaves a cause of seasonal asthma and hay fever.