They are more social than other skunks. Several may share a den over the winter. They den in hollow logs, brush piles, and the burrows of other animals. The spotted skunk is the most carnivorous of all skunks. It eats small mammals, insects, rats, mice, grapes, fruit, corn, and grubs.
Owls are the primary predator of skunks.
Owls can strike silently from above and carry off a young skunk before the parent can use its defensive spray. Spotted skunks are good climbers and will climb trees to escape from predators. They are faster and more agile than striped skunks. In early spring, four to six blind, furred young are born. They don't have the distinctive black and white spotted fur coloration until early summer.