Collaborations Incyte's Protein Function Hierarchy Keywords Incyte scientists developed both the categories and keywords that define Incyte's Protein Function Hierarchy. Incyte Genomics maintains a collection of keyword files that are used to assign protein function. Genes are assigned to a particular category by comparing their GenBank annotation to the thousands of keywords representing the hundreds of protein function categories in the hierarchy. If the annotation for a sequence matches a keyword, the sequence is assigned to the category to which that keyword belongs.
Most categories also contain anti-keywords.
If the annotation for a sequence matches both a keyword and an anti-keyword for a category, the sequence is not included in that category. Keywords and categories are updated regularly to ensure that sequences are assigned to the correct category. In addition, protein function category assignments are routinely checked manually for accuracy. Inc. All rights reserved.