Studies have indicated that standard dose may be appropriate, but interval between doses should be extended and based on patient response. This is also true with those patients over the age of 65. Half life in the elderly is increased. Preliminary studies have shown that hydroxybutorphanol may have a longer half life than the parent drug, and both metabolites have some analgesic effects on their own. This depression is reversible by Narcan.
Premature babies are especially sensitive to respiratory depression and apnea.
Smaller doses and longer time intervals between doses may be needed. Should NOT be consumed with alcohol, barbiturates, tranquilizers and antihistamines, as it may have additive CNS effects. Chronic use of Stadol and Stadol NS have led to mild withdrawal symptoms, and cases of overuse and self-reported addiction have occurred. Stadol NS should not be used for longer than 2 months and only at the prescribed interval between doses. Nasal congestion, anorexia, constipation and insomnia with nasal spray.