Our goal is to understand the mechanism of induced mutation.
More recent studies suggest that mutation is a metabolic process under genetic control.
We are correlating the appearance of mutations in vivo with the properties of the DNA polymerases used for synthesis and testing a generalization about base substitution mutation derived from our earlier studies. We are trying to obtain new mutators by specifically selecting for changes in the genes coding for the replicating polymerase and the proofreading exonuclease of E. coli. The origin of point mutations in human tumor cells.