Thousands of marriages have ended because of this statement. Thousands of marriages have survived and become loving relationships when the spouses felt this way but chose not to accept it. There is no magic or god given answer to this dilemma - it is strictly a conscious choice. You have very difficult circumstances for any marriage to survive. Physical absence for career purposes can often feel like abandonment to the spouse left behind.
Nothing hurts more than to be abandoned.
Perhaps this is also where you are coming from. If you don t understand what is inside her that leads her to make these choices, it evokes negative feelings. It suggests she doesn t love you or that she loves her career more. Yet I am sure this isn t true. Unfortunately I doubt she will ever be able to explain her feelings either.