The inclusions usually were observed within hepatocyte cytoplasm. Liver, Eclectus parrot, electron micrograph. Cytoplasmic hyaline inclusion within a hepatocyte. Notice the granular, amorphous structure. Liver, Eclectus parrot, electron micrograph.
Radial projections extend from the periphery of the hyaline inclusion into the hepatocyte cytoplasm.
A limiting membrane is not observed. Discussion Inclusions of this nature have not been described previously in the liver of psittaciform birds, but have been presented as intracytoplasmic inclusions of undetermined significance in the liver of a turkey with cardiohepatic syndrome. The inclusions described in this manuscript are very similar to hyaline globules that have been reported in the livers of laboratory animals and human beings. The formation of these globules has been related to increased hepatic pressure. Initially, when pressure is increased, vacuolation of hepatocytes occurs.