Description Tubulin is the major building block of microtubules. This intracellular, cylindrical, filamentous structure is present in almost all eukaryotic cells. Microtubules function as structural and mobile elements in mitosis, intracellular transport, flagellar movement and the cytoskeleton. 50 kD and share considerable homology. Structurally different tubulin subunits have been identified as the product of different genes.
Microtubular systems contain at least three a-tubulin isoforms.
Two isoforms are coded by two a-tubulin genes, which are both transcribed and code for extremely similar proteins. The third isoform is generated by post-translational modification. For extended storage, the solution may be frozen in working aliquots. Repeated freezing and thawing is not recommended. If slight turbidity occurs upon pro longed storage, clarify the solution by centrifugation before use.