You will discuss their dopaminergic character. However, the most serious effects are the cardiovascular and do resemble those produced by the TCA's , so with regard to symptoms there is also some similarity. Stabilize as you would any other cardiac emergency. Pharmacological treatment should be conservative due to possible interactions with other drugs. For example, TCA s are quickly absorbed, tightly bound, enterohepatically circulated.
Phenothiazines exhibit significant plasma protein binding and have large volumes of distribution.
They are radioopaque. 147-156, Principles of Clinical Toxicology 3rd edition, Gossel and Bricker. 327-354, Principles of Clinical Toxicology 3rd edition, Gossel and Bricker.