This is not fully understood. These changes sometimes disappear when the dose is reduced. Although these kidney changes are less common, they may be irreversible. The drug may cause reversible increases in liver enzymes. Liver function should be closely monitored.
Many patients develop high blood pressure.
Great care is needed in choosing an anti-high blood pressure drug. Diuretics may interact with cyclosporine. Most transplant patients develop high cholesterol levels and all of them will develop coronary artery disease. A low-fat diet is strongly recommended. Lovastatin is not to be used due to the risk of myocyte necrosis.