Oxygen radicals damage chromosonal DNA causing cell death and inducing mutations.
The human NTH1 repair protein is one enzyme that has been shown to act on a large number of these other oxidatively damaged DNA sites. The NTH protein has broad substrate specificity, including numerous ring saturation and fragmentation products of pyrimidines. NB 100-108 is specific for NTH1. This antibody can be used in Western blot analysis and detects a single band of 37 kDa representing NTH1. The investigator should determine the optimal working dilution for a specific application.