Chloramphenicol 4-6g 5. Metronidazole 1.5g 6. Cloxacillin 12g 7. Penicillin G 24 million units 8. Vancomycin 2g 14.
Most patients require surgery as part of their management.
Poor prognostic parameters, either clinical or radiographic, may necessitate earlier aspiration. Later neurologic deterioration or failure of the abscess to decrease in size as detected by CT scan, is an indication for further surgery, often excision, if feasible. The duration of antimicrobial therapy remains unsettled. Duration cannot be determined by resolution of all CT or MRI abnormalities. A cured brain abscess may continue to appear as a nodular contrast enhancement on CT scans for 4 to 10 weeks, and even up to 6 months, after completion of successful therapy.