The differential diagnosis for leukocyte inclusions, sometimes called D hle bodies, includes septicemia, myeloproliferative disorders, and pregnancy. The platelet count is decreased, but the degree of thrombocytopenia varies. The disorder is characterized by giant platelets. They are located in the periphery of the cytoplasm and are similar to D hle bodies in gross appearance. The bleeding time is prolonged in concordance with the degree of thrombocytopenia.
Platelets aggregate normally in response to various agonists.
The glycoprotein composition of the platelet surface has been found to be normal in this syndrome. The majority of patients with MHA do not experience significant bleeding problems so treatment may not be required. Corticosteroids and splenectomy are ineffective. In rare cases of severe bleeding, a platelet transfusion may be required. Prophylactic preoperative platelet transfusions also may be warranted.