Commissureless, an endocytosing molecule, coordinates cell surface remodeling. 286B Commissureless, an endocytosing molecule, coordinates cell surface remodeling. B. Wolf and A. Chiba.
Neural development offers numerous models for specifically regulated cell-cell interactions.
COMM's cytoplasmic domain contains two putative adaptin recognition sites. COMM is endocytosed before neuromuscular synaptogenesis. This phenotype is rescued by supplying wild type COMM to the muscles. A truncated COMM protein, lacking its cytoplasmic domain, fails to internalize. Misexpressing this mutant protein in muscles phenocopies the synaptogenesis defects of the mutants.