PCP use in humans occurs through either intranasal, IV, oral or inhalation routs of administration. Peak plasma concentrations occur within 5-10 minutes after PCP is smoked.
Metabolism is primarily hepatic with renal secretion of hydroxylase metabolites.
Serum concentrations above 1.0 uM are strongly associated with coma, respiratory arrest and death. Phencyclidine is well absorbed following all routes of administration. It is hydroxylated in the body and metabolites are conjugated with glucuronic acid. While some of the metabolites are active, most of the pharmacological effects are due to the parent compound itself. Only a small amount of the drug is excreted unchanged.