To find out, researchers tested the activity of the receptor in a test tube. Since progesterone increases a dramatic 100-fold during pregnancy, it offered researchers a unique opportunity to pinpoint the cause of this particular case of hypertension. Not surprising, both women had suffered severe hypertension during pregnancy, a serious condition that causes intrauterine growth retardation, early deliveries and pre-eclampsia, a potentially fatal condition. The two women produced five healthy babies between them but with complications. They delivered pre-term babies via Caesarian section and both women were advised not to have any more children.
Researchers say it is too early to discuss remedies for pregnancy-induced hypertension.
The Yale team is already developing a genetically altered mouse with a mutation in the mineralocorticoid receptor gene, a complicated process that could take more than a year. Ultimately, researchers hope their findings about steroid receptors will provide insight into more common forms of high blood pressure as well as diabetes, thyroid disease, and prostrate and breast cancer. Geller, D.S. et al . Activating mineralocorticoid receptor mutation in hypertension exacerbated by pregnancy.