Consequently, the time between replication and break formation was held constant in all regions. Abstract Global mapping of meiotic recombination hotspots and coldspots in the yeast saccharomyces cerevisiae. We used DNA microarrays to estimate variation in the level of nearby meiotic DSBs for all 6,200 yeast genes. Coldspots were nonrandomly associated with the centromeres and telomeres. Exposure of cells to environmental agents results in damage to DNA and cancer risk.
Most cancers result from low level exposures in genetically susceptible individuals.
These damage-specific phenotypes are heritable traits associated with increased cancer risks. Cataloging polymorphisms at relevant genes in the human population provides reagents for molecular epidemiology studies employing a genotype to health consequence paradigm. The average variant frequency is 0.06. Biochemical and molecular epidemiology studies provide evidence that several amino acid substitutions impact protein function, repair capacity and cancer risk. Central to many of these repair processes are nucleases, which either initiate excision of or directly excise the target damage.