Psychological manifestations of neurosarcoidosis may include apathy, lack of judgment or memory loss. Chest x-ray is the number one diagnostic tool. Definitive diagnosis requires clinical and radiological signs plus histological confirmation of noncaseating lesions. In general, the prognosis of sarcoidosis is good. However, it is unclear in which patients this will occur.
Most patients suffer no significant sequelae.
The recommended treatment of neurosarcoidosis is prednisone at an initial dose of 40 to 80 mg per day in divided doses. Often symptoms worsen when the steroids are tapered. If this occurs or if the patient is unresponsive to treatment, the dose may need to be increased. A last option is treatment with 1 to 3000 rads of radiation fractionated over several days to weeks. After radiation, steroids usually need to be resumed, sometimes at lower dosages.