The area is composed of 8817 acres of marshlands, tidal marsh areas, and open water areas. The refuge is the winter home to large numbers of migratory birds, such as Canada geese, snow geese, black ducks, mallards, and wood ducks. The area is also the year round home to many other birds, mammals, reptiles, and amphibians Canoeing and primitive camping are allowed in the area. The area is ideal for flatwater kayaking. There are over 15 miles of streams, canals, and ditches.
Marsh blinds are accessible by boat.
The refuge has several boat ramps. Fishing is also available in accordance with state and federal regulations. To get to Prime Hook Refuge cross the Bay Bridge and take U.S. 50 to to 404 southeast to 16 east. Cross Delaware highway 1, where the continuation of highway 16 becomes Broadkill Beach Rd. Proceed on this road for about one mile to the refuge entrance.