The peptide induced analgesia was totally naloxone reversible. In a human clinical trial, in which pancreatic cancer patients received chronic treatment with an LH-RH agonist analog, a decrease in abdominal pain was reported by the patients after just 3 weeks. The behavior resembled the cataleptic state induced by classical neuroleptic drugs. YES Catalepsy Increased total duration of immobility. The immobility seen in this test is NOT frank neuroleptic-like catalepsy.
Naloxone is a competitive inhibitor of opiate responses.
Paresthesia is an abnormal spontaneous sensation, such as of burning, pricking, tickling, or tingling. In the next IVF cycle, she was treated with a different GnRH-analog, this time in the form of a nasal spray. It should be noted that these four cases were the only cases reported in the medical literature that discuss paresthesia. Adverse neurological symptoms after gonadotropin-releasing hormone analog therapy for in vitro fertilization cycles. Clinical Gynecologic Endocrinology and Infertility, 2nd edition.