Effects are variable from one patient to another for the same blood level making blood levels not clinically useful in the management of dexfenfluramine and fenfluramine poisoning. The usual duration of toxicity may be 2 to 3 days. Emesis generally should be avoided because altered mental status may occur within 30 minutes post ingestion. Lavage may be indicated if performed soon after ingestion. Activated charcoal administration may be beneficial and should be instituted for most toxic ingestions.
Most intoxications are of mild significance.
However serious intoxication leading to death has been described especially with fenfluramine and therefore aggressive decontamination measures and supportive care must be instituted for these patients. Toxicologic Management, Fenfluramine and related drugs.