The answer seems obvious. True, other factors may also contribute to the causation of sore throat, but they are generally regarded as non-relevant, and ignored. Yet we hardly ever examine whether this is really so, and may miss significant causes.
Medicine lacks a procedure for systematically examining causes of a disease.
The basic stuff of which the disease is composed. Better, the benefit of the disease for the patient. Sore throat 1. An undernourished patient responds differently to sore throat than a well nourished one. The benefit of sore throat for the patient.