Some physicians prescribe saquinavir in combination with another protease inhibitor, ritonavir. Studies are underway using a single daily dose of saquinavir taken with a small amount of ritonavir. Saquinavir should be taken within two hours after a full meal or a large snack. Your pharmacist should keep saquinavir refrigerated. The side effects of saquinavir are usually mild.
Most people can take it with no problems.
However, some people get nausea, diarrhea, upset stomach, and heartburn. Saquinavir is broken down by the liver and can interact with other drugs that also use the liver. Combining these drugs can change the amount of each drug in your bloodstream and cause an under- or overdose. Drugs to watch out for include several antihistamines, sedatives, and anti-fungal drugs. Make sure that your doctor knows about ALL drugs you are taking.