Maintenance personnel should be trained in and equipped for biosecurity. Barn doors and hallway fire doors should be kept closed. It is not practical for multiple age farms or areas where the disease is endemic. These vaccines elicit a strong long lasting immune response. These vaccines also are initially more stressful to the birds, cause a strong local reaction and may affect egg production adversely if flocks in production are vaccinated.
Protection is of shorter duration than with oil emulsion vaccines.
Live attenuated vaccines or controlled exposure with milder strains of coryza have been used in some places in the past. It is best to serotype isolates from the affected farm. Serotype A vaccine should be used if this serotype is present on the farm. Vaccines that contain all three serotypes should be used if the serotype causing the disease is unknown. Oil emulsion vaccines are preferred in endemic areas.