A on surrogate markers in HIV-positive patients with no previous antiretroviral therapy. With the plant source proving to be rare, MediChem Research, Inc., synthesized the compound. A with healthy volunteers, who received escalating single doses or multiple doses, showed the compound to be well-tolerated. It was absorbed and circulated in the bloodstream, resulting in higher blood concentrations than anticipated from animal data. The most frequent adverse effects were dizziness, oily aftertaste, headache, belching and nausea, which were mild to moderate.
Pharmacokinetic analyses suggest once or twice daily dosing.
Animal studies have shown the compound to penetrate into viral reservoir sites by crossing the blood-brain barrier into the brain and accumulating in the lymph nodes. A. Formed in 1987, MediChem Research is a privately held pharmaceutical products and services firm specializing in custom organic synthesis. It also has a worldwide exclusive license to the National Cancer Institute patents on composition and use of the compound, as well as to the rights held by the government of Sarawak.