There is a blurred overlap with nutritional and tobacco alcohol amblyopia, but this entity has virtually disappeared. Patients are probably wise not to change their diets excessively to avoid cyanide as virtually all food contains some cyanide. Almonds are realistically the only food to avoid. Ortiz et al. It may be that ECG abnormalities are confined to some families.
Neurological abnormalities are common.
LHON is a disease we understand. Molecular abnormalities suggest that the use of coenzymes or free radical scavengers may help. When reviewing any report of recovery of vision, one must always consider that the patient was probably young and may have recovered anyway. Recently, idebenone 28,29 has been reported to reverse visual loss. As yet unpublished reports fail to support the initial promise of this treatment.