Never use bitmap images of text. They are impossible for the blind to read. Low vision users can enlarge them, but persons who are legally or totally without any sight, can never read text images. Navigation is a challenge for blind and visually impaired users. Whereever possible, try to minimize the number of multiple hypertext links that appear in a single line of text.
Navigation is also difficult in web pages that feature multicolumn displays.
These are a nightmare for the blind. Thus, when the browser displays a multicolumn document, the screen reader reads each line, jumping from column to column until it reaches the end of the line. This makes it very difficult for the user to follow, since there is no logical construct for the screen reader to follow. If you are a publisher of online journals, newspapers, or magazines, consider providing an alternative view of your text that is not multicolumn in format and that can be downloaded. Additionally, in every case, include keyboard equivalents for mouse commands.