It is a curse that befalls all who are born in this world. There is nothing that we can do in and of ourselves to remedy this. Some people are born with a family history of heart disease or some other ailment. Satan uses the illusion of beauty for sin to conceal its deadly effect and to keep people from the healing knowledge of Jesus Christ and His blood that was shed at Calvary. Sin appears attractive for a short time.
Many people place higher priority in temporal comforts rather than the eternal comforts of The Lord.
This is an effect of the the inherent sin nature, the cancer, that is present in all people. Like cancer, sin is progressive in nature. Both of these men started out with one sin, then with each one committed came another. Lot began by choosing economical profit over God then ended up committing incest. David began with adultery and ultimately ended up comitting murder.