A female inherits her father's allele and one of her mother's alleles. Checking Genotypes Further Genotypes can be wrong, but still consistent with Mendelian rules. Wrong genotypes usually increase the estimate of . Convince laboratory personnel to follow-up based on GenoCheck output. Each likelihood evaluation takes roughly the same amount of time.
Programs take a checkpoint after every likelihood evaluation.
Compare observed A to expected. Very sensitive to allele frequencies. Given a probability distribution of inheritance vectors, conditional on phenotypes, compare this to uniform distribution. Improves APM by conditioning simulation on affection status. You get empirical p-values.