The suppressor factor has been shown to be nitric oxide, which is produced by activated macrophages. Both treatments block NO production. IL-12 and NO in cellular trafficking to the spleen. These studies are of importance as they raise the possibility that live, attenuated Salmonella vaccines may induce a period of immunosuppression as a side effect of their administration. T.J. Rogers, J.J. Meissler, Jr., M.W. Adler, and M.E. Hilburger.
Morphine depresses macrophage numbers and function in mouse spleens.
Plenum Press, New York, p. 33. T.K. Eisenstein, M.W. Adler, and T.J. Rogers. Plenum Press, New York, pp. T.K. Eisenstein, M.W. Adler, and T.J. Rogers. Characterization of k -opioid receptor transcripts expressed by T cells and macrophages.