Research on carbohydrate structures on cell surface glycoproteins is identifying novel therapeutic and diagnostic approaches to cancer. The Institute plays a major role in the O.C.G.N., an Ontario-wide network of scientists and clinicians investigating the molecular genetics of inherited predisposition to cancer. Institute scientists have pioneered research which has given rise to gene knock-out and gene trap technologies, enabling the targeted deletion of genes of interest and the identification and analysis of the pattern of expression of genes which play a critical role in development. Programs also focus on the molecular genetics of the development and function of the nervous system, including characterisation of genes that regulate the migration of neurons in the developing nervous system. In addition, research programs focus on the development of new diagnostic technologies and treatments directed at pathologies of pregnancy including pre-eclampsia and premature labour.
Research programs focus on biostatistical methodologies and design and analysis of clinical trials.
Expertise in molecular genetics and clinical epidemiology are being combined to understand the role of genes in health and disease. Research is focused on determining the genetic basis and molecular biology of polygenic diseases such as asthma, type II diabetes, hypertension and gastro-intestinal disease. Research programs focus on bone and mineral metabolism, cell biology, bone physics and the metabolism of cartilage as well as associated degenerative diseases of bone and cartilage, such as osteoporosis and arthritis. A variety of innovations have resulted from this research leading to collaborations with companies to develop novel therapeutic approaches, both pharmacological and structural, including reconstruction of bones and joint surfaces. Specific projects investigate the modular domains of proteins, cell signalling and regulation of the cell cycle.