This may be due to such things as incorrect calibration of equipment, consistently improper use of equipment or failure to properly account for some effect. In a sense, a systematic error is rather like a blunder and large systematic errors can and must be eliminated in a good experiment. But small systematic errors will always be present. For instance, no instrument can ever be calibrated perfectly. Other sources of systematic errors are external effects which can change the results of the experiment, but for which the corrections are not well known.
Random errors are errors which fluctuate from one measurement to the next.
They yield results distributed about some mean value. They can occur for a variety of reasons. They may occur due to lack of sensitivity. For a sufficiently a small change an instrument may not be able to respond to it or to indicate it or the observer may not be able to discern it. They may occur due to noise.