Kofuji P. RGS proteins reconstitute the rapid gating kinetics of Gbeta, gamma-activated inwardly rectifying K channels. Time resolved kinetics of direct Gbeta1,gamma2 interactions with the arboxyl terminus of Kir3.4 inward rectifier K channel subunits. The inward rectifier potassium channel family. Problems currently under study include methods of detecting recurring spatiotemporal patterns of activity. Repeated sequences of interspike intervals in baroresponsive respiratory related neuronal assemblies of the cat brainstem.
Research involves the neural control of cardiorespiratory function.
Recent research has focused on the effect of carotid chemoreceptor stimulation on distributed brainstem neural networks involved in cardiorespiratory control. Currently part of a team organized for the design and production of an array of 32 individually adjustable microelectrodes and concomitant data acquisition, recording and entry equipment. Repeated patterns of distributed synchrony in neuronal assemblies. Historically, most of my work has involved the pubertal transition and the endocrine and neuroendocrine factors involved in the control of the onset of puberty and this remains a strong interest. A relatively new project is examining the role of the recently discovered hormone leptin and its role in male reproductive physiology and puberty.