If we carry ill-feeling or hatred or jealousy in our minds or hearts, these create discomforts. We lose sleep and need to rely more and more on tranquilizers, sleeping pills, and things like alcohol or drugs. If one has lost the inner ability to sustain peace of mind, happiness, or joyfulness in life irrespective of external facility, then people usually seek refuge in alcohol or drugs or things like that. These are literally very limited remedies so that once one becomes stuck within their limitations, one has few options available. It is a mistake to rely too much on external means and to completely neglect our inner life, our inner ability, our inner resources.
Negative emotions are very harmful for one's self, one's body, and one's mental well-being.
They will destroy or spoil all the chances for our future. On the other hand, an open heart, a warm heart, will bring more smiles, more reliable friends, and in that way a great fortune in life. If you have devoted your life to some meaningful activities motivated by a sense of caring, I think that when the last moment of your life comes, you will not have any regrets. Now I am dying. My life is now ending here, but I have no regrets.