The proper use of these tests and their interpretation should become more clear as the results of recent trials become available. No one knows the ideal duration of therapy. In osteoporosis trials, bone loss can be measured in only a few months after discontinuation of bisphosphonate. We advise treatment with bisphosphonate be continued indefinitely. Bisphosphonates such as pamidronate taken at the prescribed dose and schedule are safe and effective.
Rapid infusion can cause a chemical inflammation at the injection site along the path of the vein.
Slower infusion may avoid this complication. Too rapid an infusion can also cause a low blood calcium. Most patients, however, tolerate infusions over 2 hours rather than 4 hours without side effects. Dosage in kidney failure should be reduced since bisphosphonate excretion is delayed. Intravenous pamidronate can cause inflammation of the eyes, but this side effect is treatable.