JE Nestler, DJ Jakubowicz, A Falcon, VC Brik, N Quintero, F Medina. Insulin stimulates testosterone biosynthesis by human thecal cells from women with polycystic ovary syndrome by activating its own receptor and using inositolglycan mediators as the signal transduction system. David Maggs of Yale University annual meeting of the American Diabetes association in Boston, November, 1997. Metformin monotherapy for type II diabetes. Unwanted effects such as hypoglycemia, weight gain, and increased fasting insulin levels have sometimes been associated with sulfonylureas.
Metformin improves glucose intolerance without stimulating insulin release or causing hypoglycemia.
Additional benefits associated with metformin include a favorable influence on body weight and plasma lipid profiles. Metformin is an important first-line alternative agent for patients with type II diabetes. YkiJarvinen, K Nikkila, S Makimattila. Metformin prevents weight gain by reducing dietary intake during insulin therapy in patients with type 2 diabetes mellitus. Dr. Mirkin's opinions and the references cited are for information only, and are not intended to diagnose or prescribe.