Possible side effects of Provera include fluid retention, weight gain, depression, fatigue, nausea, acne, migraine, breast tenderness, spotting between periods. Hormones taken orally enter the bloodstream from the small intestine, and go directly to the liver. Because the liver is not accustomed to receiving large amounts of hormones, it begins to break them down, leaving only a small percentage of the ingested hormone available to cells. Transdermal delivery circumvents the digestive system cells absorb hormones more efficiently, rapidly dispersing them into the blood via capillary beds in skin and muscle. Martha Howard, M.D. says, oral pharmaceuticals can be harmful to the liver and gall bladder.
Oral administration is outmoded.
Plant-derived creams fit better in the body s receptors. I prefer transdermal delivery systems it s safer and more natural. When progesterone supplementation is inadequate in relieving hot flashes, sweating, and vaginal dryness, herbs that tonify Yin, dispell Heat, and astringe Moisture should be used. Women concerned about or diagnosed with breast cancer wonder whether they should use natural progesterone cream. A Johns Hopkins study published in 1981 found that women with low progesterone levels had a 5.4 times greater incidence of breast cancer and a 10 times greater incidence of general malignancy.