Position available in immunoreceptor signaling group consisting of two core faculty, graduate students, postdoctoral fellows, and technicians. The laboratory specializes in IgE receptor-mediated signal transduction and regulated exocytosis in basophils and mast cells. The applicant will work in collaboration with a core of scientists who will study the utility of rapidly-generated genetic vacccines in protection against viral pathogens. A wide range of methods will need to be employed, including neutralization tests for viral antibodies, preparation of tissues for pathologic studies and immunostaining, PCR, and DNA sequencing. Experience with biologically hazardous microbes is desired.
Minimum requirement is a Ph.D. in Biochemistry or related fields.
The successful candidate will work with a group of other postdoctoral fellows, technicians, and faculty working on problems of immune regulation in the lung. The work involves models of asthma and lung infections and requires a basic fund of knowledge of immunology, some animal physiology and morphology, and an interest in microbiological problems. The laboratory is developing new approaches for the real-time analysis of ligand binding and macromolecular assembly including rapid kinetic flow cytometry. The laboratory is also investigating the molecular basis of neutrophil and eosinophil adhesion. We have recently developed new tools for high throughput screening in drug discovery.