The liver may become enlarged in infectious conditions. The liver contains many cells which trap foreign organisms and this may set up an enlarged, sometimes tender liver. The possibilities should be investigated by your primary physician. The liver enzymes and functional status should be checked. An ultrasound of the liver may be helpful.
Neonatal hepatitis is an inflammatory reaction within the liver in newborn infants.
It presents with jaundice and a large liver. Most cases resolve, but some cases progress and may even require liver transplantation. I am interested in any information you have about this disease in children. It is often associated with inflammatory bowel disease but may be seen in a number of other conditions. Sometimes it must be treated by liver transplantation.