Female children may also have a specific syndrome, Aicardi's syndrome, in addition to ACC and infantile spasms, in which there is severe mental retardation and chorioretinal lacunae. ACC is also sometimes associated with complex multi-system malformations and with several chromosomal anomalies, including trisomy 13 and 18. There are non-nervous system malformations that may occur both with and without chromosomal aberrations such as midline facial defects. Treatment usually involves management of symptoms such as hydrocephaly and seizures if they occur. ACC does not cause death in the majority of patients.
Mental retardation is nonprogressive.
Selected references Lassonde, M, Sauerwein, H, McCabe, N, Laurencelle, L, and Geoffroy, G. Extent and Limits of Cerebral Adjustment to Early Section or Congenital Absence of the Corpus Callosum. Clinical, Neuroradiological and Cytogenetic Studies. This fact sheet is in the public domain. You may copy it.