Magnesium is an essential element in human metabolism and functions in the activities of muscles and nerves, protein synthesis, and many other reactions. Magnesium deficiency may occur in alcoholism, diabetes mellitus, pancreatitis, and renal diseases.
Prolonged deficiency can cause changes in heart and skeletal muscle.
Excessive retention of magnesium can occur in renal disease and results in muscle weakness and hypertension. The only established use of riboflavin is in the therapy or prevention of deficiency disease. Biotin, Choline, and Inositol Biotin, a complex organic acid containing sulfur, is a coenzyme for several carboxylation reactions involving carbon dioxide fixation. It is synthesized by intestinal bacteria and is widespread in food products. A natural deficiency in humans is unknown, even in individuals on extremely deficient diets.