The overall goal of the program is to investigate the effects of radiation on human tumor cells at the molecular level.
Research focuses on genes that effect cellular radioresistance.
The involvement and biological effects of growth factors and cytokines on signal transduction and transcriptional activation after radiation are of particular interest. The group is pursuing novel approaches to genetically manipulate radioresistance which show promise in altering cellular radiosensitivity. The successful applicant is expected to complement a highly interactive, multi-disciplinary program that investigates the molecular mechanisms of signal transduction, cell proliferation, and apoptosis underlying tumor radioresistance and applies novel approaches to radiation treatment using drugs and gene therapeutic tools. Applicants with interests in DNA repair, signal transduction, and cellular redox effects are particularly encouraged to apply. Applications should include a CV, reprints of publications, a statement of research plans, and three letters of recommendation.