After infection, paravasuclar inflammation of mononuclear cells occurs with vessel acclusion, oxygen starvation, anoxia and eventually death. Trypanosoma bruci rhodensie - Agent of African sleeping sickness in East Africa. Tsetse fly transmitted. Found in different animals with different clinical signs. A severe acute disease in horses donkeys, dogs, goats and camels but producing only a chronic disease in cattle.
Many wild ruminants serve as non-clinical reservoirs.
Many other animals are also susceptible to infection. Trypanosoma vivax - Similar to T. congolense. This is a sexually transmitted disease of horses. Acute signs are characterized by swelling of the genitalia. This organism has been eradicated from U.S. but occasionally reappears.