Lesions can be pruritic or painful. Lesions caused by some species can heal without pharmacotherapy, but healing can take months. Mucocutaneous leishmaniasis Incubation period is from 1-3 months. Mucosal lesions become gradually painful. Initial symptoms include nasal obstruction and bleeding.
Many subclinical cases occur for each clinically recognized case.
Malnutrition has been shown to contribute to the development of clinical disease. Onset is insidious. Fever can be continuous, intermittent, or remittent and it can recur at irregular intervals. Initially, the lesion is a small red papule, up to 2 cm in size. The papule ultimately ulcerates.