Use alcohol cautiously. Alcohol may increase drowsiness and dizziness while you are taking amitriptyline and perphenazine. Amitriptyline is in a class of drugs called tricyclic antidepressants. Amitriptyline is also sometimes used to treat certain types of pain. Perphenazine is in a class of drugs called phenothiazines.
Perphenazine is used to treat psychotic disorders and nausea and vomiting.
Amitriptyline and perphenazine work by changing the actions of chemicals in your brain. The combination, amitriptyline and perphenazine, is used to treat depression that is accompanied by anxiety or agitation. Amitriptyline and perphenazine may also be used for purposes other than those listed in this medication guide. You may not be able to take amitriptyline and perphenazine, or you may require a lower dose or special monitoring during treatment if you have any of the conditions listed above. It is not known whether amitriptyline and perphenazine will harm an unborn baby.