The subunit, dubbed NR3A, appears to regulate the activity of the NMDA receptor in ways that may protect nerve cells from damage. Their findings are published in the May 28 Nature.
NMDA receptors are important in nerve cell migration and synapse formation during development.
Paradoxically, NMDA receptors are also responsible for nerve cell injury in a variety of neurologic diseases, including stroke, head and spinal cord trauma, and various forms of dementia, including AIDS dementia. In 1995, Stuart Lipton, HMS associate professor of neuroscience at Brigham and Women's Hospital, and his colleagues cloned a gene that he and Nobuki Nakanishi, HMS assistant professor of neurobiology, and his colleagues now show is an NMDA receptor subunit, dubbed NR3A. Nakanishi s lab also produced mice that lack the NR3A subunit. Mice that do not have the NR3A subunit appear normal and lack apparent behavioral abnormalities. When Lipton's laboratory conducted electrophysiological tests, however, they found heightened NMDA receptor activity in the nerve cells of these mice. Ionic current was 2.8-fold higher than in neurons containing the NR3A subunit, increasing the amount of calcium entering nerve cells.