Pain insensitivity is common. Dental complications include malocclusion, enamel hypoplasia, and caries. Thick saliva seen at the edges of the mouth. Osteoporosis and delayed bone maturation. Infertility, hypogonadism, scrotal hypoplasia, cryptorchidism, and small penis.
Precocious puberty occurs in some patients.
The affected children and adolescents tend to be placid and pleasant but many have problems with psychosocial adjustment, some even become self-destructive. Listed in OMIM in the autosomal dominant catalog.