Lora Hedrick Ellenson Advanced Search Lora Hedrick Ellenson, M.D. Associate Professor Department of Pathology Molecular genetics of endometrial carcinoma Endometrial carcinoma is the most common malignancy of the female genital tract. Although it is often thought of as a single disease, there is epidemiological and clinicopathological evidence to support the view that it encompasses two broad categories of malignant epithelial tumors. Each broad category is composed predominantly of one histological type of endometrial carcinoma. We are currently using molecular approaches to define the differences, and the similarities, in the molecular genetic alterations of the two types of endometrial carcinoma.
Microsatellite instability is uncommon in uterine serous carcinoma.
Mutations in PTEN are frequent in endometrial carcinoma, but rare in other common gynecological malignancies. Weill Medical College of Cornell University. All rights reserved.