J.A. Wingrove and P.H. O'Farrell.
Oxygen plays an essential role in many cellular processes.
Because of this, organisms have developed the ability to sense and respond to low oxygen levels. In order to understand how an organism senses oxygen levels, we have chosen to characterize the effect of hypoxia on Drosophila at the behavioral and cellular levels. Hypoxia results in elevated PKG activity in dissected CNS and spiracles. NOS also appears to play a role in hypoxia-induced roving. Transgenic larvae containing hs-NOS show increased sensitivity to hypoxia.