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Recurrent apnea is common in preterm infants, particularly at very early gestational ages.
These episodes of loss of effective breathing can lead to hypoxemia and bradycardia which may be severe enough to require resuscitation including use of positive pressure ventilation. Each reviewer assessed eligibility, trial quality and extracted data separately, then compared and resolved differences. Study authors were contacted for additional information. Three trials involving a total of 66 infants were included. The quality of these small trials was fair to good.