The faculty included university and medical school professors from institutions around the world, such as Johns Hopkins University, NIH, Mayo, Harvard, UVA, UCLA, UCSF, and many more. Some were from foreign countries, including England, Italy, Holland, and Austria. This was an excellent conference with an excellent faculty. The information below is derived from lecture notes and from informal discussions with the faculty during lunch, breakfast, and lecture breaks.
Resistance occurs gradually after the first few months of use.
Even the most effective secretagogues have limited long term benefit. Secretagogues that stimulate HGH release also stimulate ACTH and increase cortisone levels produced by the adrenal glands, which normally increase to undesirable levels with aging anyway. Merck Pharmaceutical Company discontinued research on one such secretagogue, a peptide mimic called MK-677, partially for that reason . Aerobic exercise acts to partially reverse and slow age-related loss of cell response to peptide hormones. That benefit decreases with age.