Oxygen radicals damage chromosomal DNA causing cell death and inducing mutations.
A significant amount of 8-OxoG is formed in the chromosomal DNA of mammalian cells, with most damaged nucleotides excised from the DNA and excreted in the urine. NB 100-109 is specific for human MTH1, with some homology to mouse and rat. The investigator should determine the optimal working dilution for a specific application. Avoid repeated freeze-thaw cycles. Production of this antibody was supported by SBIR grant R43CA83507-01.