It is essential to understand the molecular and cellular events of prenatal development, in order to appreciate how they become disturbed during the origin of clinically important birth defects. The ultimate goal is to develop new therapeutic methods that can prevent the development of the birth defects. Close links exist with clinical departments at the Medical College of Georgia, enabling rapid transfer of basic science findings to the pediatric environment. A candidate multiple-copy spermiogenesis gene on the mouse Y chromosome. In Situ Hybridization of Cell and Tissue Sections.
Neural crest is involved in development of abnormal myocardial function.
Role of Cardiac Neural Crest Cells in Cardiovascular Development. Prevention of Allogeneic Fetal Rejection by Tryptophan Catabolism. Segmental Expression of Aggrecan in the Non-Segmented Perinotochordal Sheath Underlies Normal Segmentation of the Vertebral Column . Novel expression of the goosecoid transcription factor in the embryonic mouse heart. Rib truncations and fusions in the Sp2H mouse reveal a role for Pax3 in specification of the ventro-lateral and posterior part of the somite.