Heart Research Institute - Herston. Therefore, this most essential trace element must be chaperoned around the body in order to limit its toxicity. An intricate metabolic web exists to metabolise Fe, and it is well known that this metal ion is poorly excreted by humans.
Numerous circumstances can cause Fe overload, for example, genetic disorders such as b -thalassemia.
If left untreated, these conditions can dramatically shorten the life-span of patients. However, DFO has a number of well-known limitations, and these have sparked the search for more effective alternatives. All rights reserved.