Nulls are let, unc, dpy and Deformed. Nulls are let, unc, dpy and Deformed. Reporter genes driven by els-2 promoter and enhancer fragments exhibit a complex embryonic expression pattern including alternating stripes of dorsal hypodermal cells.
Neuronal expression is seen in many motorneurons, sensory neurons, and various ganglia.
Muscle expression is also observed. Both ev574 and ev575 delete the first exon, the 5'UTR and possibly promoter and enhancer elements. Brood size for strains homozygous for ev574 and ev575 are very low. Survivors are uncoordinated, dumpy, and severely deformed, especially near the posterior. Phenotypic and genetic analysis is ongoing.