Spectrum of antimicrobial activity. Silver nitrate is prepared with distilled water resulting in an extremely hypotonic solution leading to electrolyte imbalance. Methaemoglobinaemia is another potential complication, owing to the reduction of nitrate to nitrite by bacteria. Nitrofurazone Mechanism of action. It appears that the drug acts by inhibiting bacterial enzymes involved in carbohydrate metabolism.
Organic matter inhibits the antibacterial action of nitrofurazone.
Spectrum of antimicrobial activity. It is not however particularly active against most strains of P. aeruginosa and does not inhibit fungi or viruses. S. aureus and E. coli can develop resistance to nitrofurazone. With good eschar penetration, it can be used in the treatment of invasive burn wound infections with sensitive agents. The drug presents some advantages for the ambulatory patient.