Given good software, the larger screen will in effect increase the resolution, which is helpful. Adjust blinds or shades to minimize the amount of direct light on the screen. Adjust lights and the monitor to keep light from reflecting into the eyes. Cover white shirts with a darker jacket or sweater. Clean the screen regularly.
People blink less frequently when they fix on the screen, and the eyes become dry.
Remind yourself to blink. Do this at least every hour. That makes the eyes dry more quickly, and the position bothers the neck. Try looking at the monitor screen at an angle 10 to 20 degrees below the horizontal, directly in front of the eye . Adjust the chair so the screen can be read without leaning forward.