The other study in mice and the other two studies in rats were inadequate for evaluation.
Reserpine is embryotoxic and has effects on reproduction.
There is limited evidence that it is teratogenic in experimental animals. It was not mutagenic in Salmonella typhimurium . 5.2 Human data Reserpine is used mainly for the treatment of mild or moderate hypertension. Thirteen case-control and two cohort studies on the relationship of reserpine to breast cancer were available to the Working Group. Between and within studies, estimates of relative risk for different measures of reserpine use varied from as low as 0.6 to over 3.