Our laboratory is interested in the role of oxidative stress in aging, cancer and heart failure.
Oxidants are ubiquitous.
They are byproducts of aerobic metabolism. The level of oxidants increases as a result of radiation, intoxication of certain xenobiotics and disease states involving inflammatory response or ischemia-reperfusion. Experimental evidence supports the Free Radical Theory of Aging, suggesting a role of oxidative stress in aging. Since aging is the highest risk factor for many life-threatening diseases including cancer and heart diseases, it is important to understand how our body deals with oxidative stress at the cellular and molecular level. Molecular Mechanisms of Oxidative Stress Response.