Ras is only expressed as mutant in some locations in animals. Has an immune response to peptide but not to mutant protein unless it is digested. 12 Ras and found positive sera. Animals which had antibody had tumor. Need T-cell response to get antibody.
Many papers suggest that there is enhanced induction and growth of primary tumors.
Wijesuriya R et al. Transfected tumor with FasL and saw decreased CTL response to tumor and decreased helper response. FasL expression also suppresses the induction of alloantibody. In animals preimmunized with CT26FasL saw delayed response to tumors and elimination compared to CT26 alone. Renca transfected with adenovirus FasL resulted in very rapid elimination.