As noted above, impaired folate metabolism has recently been implicated as a factor in Down syndrome. Wilson's Disease People with this inherited disorder have excess copper accumulate in their bodies. Zinc supplementation therapy is used to reduce copper levels and has been successful in treating the disorder. Most cases of blue sclera have been linked to iron deficiency. Sulfocysteinuria - Also known as sulfite oxidase deficiency.
Patients often respond well to a low sulfur diet.
Interestingly, one of the features of sulfite oxidase deficiency is dislocated lenses. Dislocated lenses are also a feature of homocystinuria, another genetic disorder that responds to diet therapy. Perhaps this is an indication that the dislocated lenses in Marfan syndrome may also respond to nutritional therapy, too. Spina Bifida - Reduced significantly through maternal supplementation of multivitamins with folic acid. If you search the OMIM database, the sample of features listed below are each mentioned in the write-ups for a wide variety of genetic disorders, usually as features of the disorder.