Several other disease genes are located in this area. These linkage data confirm and refine the map location for the gene responsible for CLS in Xp22.1-p22.2. No linkage heterogeneity was detected. Changes in DNA Mutations of three nucleotides appear to be linked to Coffin-Lowry syndrome. Ongoing research Research is continuing in the area of identifying the specific gene that causes Coffin-Lowry syndrome.
Researchers use markers to locate and map gene locations.
Two complementary strategies are being used for the selection of expressed sequences. These are being tested for cross-hybridization and derived nucleotide sequences analyzed for the presence of potential exons. DNA sequencing The specific gene for Coffin-Lowry syndrome has not yet been identified. Consequently, CLS has not been sequenced. Furthermore, it is not known how many introns and exons are present, nor what the length of the entire gene is.