Siamese and Oriental Shorthaired cats have been reported to develop fatal liver hemorrhage from amyloid deposition in the liver. Amyloid deposition can be rapid and severe resulting in signs of renal failure or deposition can be mild and only identified at necropsy. The mode of inheritance is not yet known. Physical examination findings are also those of CRF including dehydration, stomatitis, pale membranes and small, irregular kidneys. Laboratory findings include azotemia, hyperphosphatemia, non regenerative anemia, acidosis and isosthenuria.
Proteinuria is usually mild or absent but occasionally can be severe.
Although treatment with DMSO or colchicine may reduce the rate of amyloid deposition, experience is limited. Treatment is primarily supportive treatment of chronic renal failure . Familial renal amyloidosis in the Sharpei dog is also called Sharpei fever or Sharpei hock syndrome as it begins with episodes of fever and swollen hocks. The fever and joint swelling are self limiting but often reoccur. Signs may develop in pups or adults.