Forty percent of the genes are previously unknown. 113 genes have been transferred into the human genome from bacteria. The 'complete' sequence is still riddled with gaps. One of the most common transposable element, Alu , tends to cluster where there are genes. Chromosomes vary widely in the number of genes they contain.
Most mutations occur in males.
There are more than four million genetic differences between humans found so far. Our environments are critical. Many of us have been saying the same decades before the idea for the human genome project had ever been conceived of. John Sulston, Head of the Sanger Centre in Cambridge in the public consortium, attempts to save face by appealing to 'executive' genes that do very sophisticated 'management' work. But that only leads us into the infinite regress of having to postulate genes that control genes that control yet other genes.