Death is often due to hemorrhage. Access More Information V. fetal tissues, placenta, interstitial tissues Appears to be necessary for extracellular matrix assembly in connective tissues. Knockouts of this gene in mice have spinal deformities and poor skin and eye development. This collagen is also a proteoglycan, combining with chondroitin sulfate and dermatan sulfate. It is probably covalently linked to Type II collagen in hyaline cartilage.
Mutations can cause epiphyseal dysplasia.
Embryonic skin and tendons Based on its position in dense connective tissues, this collagen is thought to crosslink fibrils and resist shear forces on skin and tensons. All basal laminae Mutations of one of the genes involved in making collagen IV produces Alport's syndrome. Here, the glomerular basement membrane fragments. Patients with epidermolysis bullosa, a hereditary disease characterized by the blistering of the skin, have mutations in the COL7A1 gene. This is a transmembrane collagen that is associated with hemidesmosomes.