Each trial demonstrated effectiveness of yohimbine as compared with placebo, although the difference in two trials was not statistically significant. Lack of significance is likely due to the studied population, mixed etiology of ED, and endpoint measures in these studied. Clinically, the use of yohimbine resulted in an overall positive response over placebo and was well tolerated. The severity of adverse outcomes was not reported in this study. Recommendations for clinical practice Despite the limitations of this meta-analysis, the clinical data are convincing that yohimbine is effective.
Many patients favor medication over mechanical aids or injections.
The side effects are mild and reversible. Montagne DK, Barada JH, Belker AM, et al.