It is being between devil and the deep sea. Thus the choice of women whether to undergo HRT is not an easy one. This growth may continue uncontrollably, resulting in cancer. It is generally administered in small doses to minimize this complication. Generally, for women who have a uterus, a synthetic form of progesterone called progestin is added to estrogen to counteract estrogen's dangerous effect on the uterus.
Progestin reduces the risk of cancer by causing monthly shedding of the endometrium.
The drawback to this approach is that menopausal women resume monthly bleeding. Other unpleasant side effects of progestin include breast tenderness, bloating, abdominal cramping, anxiety, irritability, and depression. Only about 15 percent of women who are eligible for hormone replacement therapy are now receiving it.