Its mechanism of action is that it inhibits bacterial DNA gyrase activity. Resistance emerges with single drug use. Coumermycin Is another coumarin derivative with affinity for DNA gyrase. An intravenous preparation has recently been developed. Successful treatment has been reported in a few patients with bacteraemia.
Resistance emerges when the drug is used alone.
Clinical trials of streptogramins for staphylococcal bacteraemia in humans are under way. Transmission occurs primarily from colonized or infected patients to others via the hands of health care personnel. Health care Workers with MRSA Colonization Are associated with transmission only in a minority of instances. Generally no treatment is indicated. Vancomycin is currently the drug of choice to treat infections due to MRSA, but it does not eradicate carriage.