He then explored, via a wealth of examples, how functional relationships between distant proteins could be revealed, with computations leading to new experiments. Thus, AIDS anti-virals followed from crystallographic studies on renin and the aspartic proteinases. The human pentraxins were shown to be related to the lectin family. Other studies followed for insulin, and many others. The potential of these approaches in the context of genomes would be very powerful, and software written within his group eg for domain identification would allow targeting of new proteins with similar domains.
Many mysteries clearly lie in store.
She led on to recommendations for much more automated and intelligent help tools for users of programme packages. From these inequalities modern direct methods were born. Modern workstations now allow a million point Fourier Transform in a couple of seconds, and opened up such direct methods to calculations on proteins. The relative merits of anomalous scattering, direct methods and combinations of these methods were explored in the discussion. A career tour involving especially Munich and Uppsala, and other places on the way, with machine specs in vax units and costs in Ferrari units, showed just how far computer price performance has improved.