One major goal of our current work is to increase the number of sera from patients and controls, and to correlate this data with other criteria, including results from biopsy. The factors controlling metabolite flow and gene expression for the enzymes of this pathway have been the subject of intensive investigation for several decades. An RNase P mutation increased the stability of the ilvEDA and ilvE transcripts. Strains with mutations in RNase II and PNPase had more stable transcripts compared to the isogenic wild type strain. Quinate metabolism and lignin formation in the loblolly pine Quinic acid is one of the most abundant natural products in the biosphere.
Quinic acid is exceedingly active as an intermediate which possesses alternative metabolic fates.
In xylem-forming cells it is mainly transformed to phenylpropanoid precursors of lignin. In autotrophic cells, on the other hand, quinic acid is an effective precursor of other phenolic compounds - the most noteworthy ones being chlorogenic acid, gallic acid and protocatechuic acid. Chlorogenic acid and gallic acid confer resistance to herbivore predation and phytopathogenic microorganisms. Protocatechuic acid is catabolized to central intermediates and can serve as a carbon-source reserve during dark metabolism. Finally, quinic acid is a highly soluble readily transported metabolite that can serve as a versatile precursor of aromatic amino acids in different tissue compartments.