Major depressive illness will include endogenous, unipolar, and manic-depressive depression, involutional melancholia and masked depression. Reactive depression will include neurotic depression. Cataplexy accompaning narcolepsy.
Medical supervision is essential.
Individualise dosage according to patient needs and tolerance. Caution in elderly and adolescent patients. When distict improvement has occured, adjust the daily dosage to a maintenance level averaging 2 - 4 25mg tablets or one SR 75 Divitab. Anafranil may be given traditionally in divided doses throughout the day or may be administered in a single dose at bedtime by administration of the doses of 10mg or 25mg tablets or sustained release divitabs of 75mg. The dosage should be built up gradually for the single bedtime dose, in order to ensure maximum tolerability.