Risk Factors for Breast Carcinoma Personal history of breast cancer. Family history in premenopausal mother or sister, especially if bilateral. Previous biopsy of severely atypical hyperplasia or related pathologies. Well-defined solid masses are sometimes malignant. One of the chemotherapeutic agents frequently use, adriamycin, can have cardiac toxicity, so pre-treatment nuclear medicine study of heart will be performed so that any cardiac toxicity can be monitored.
Patient often presents to family practitioner or dermatologist for scaling, ulcerated nipple.
Need to be suspicious that Paget's indicates an underlying breast cancer.