Differences in simple etiquette may prevail, including the proper way to present business cards. Language issues such as simultaneous translations via headsets and the translation of handouts must also be addressed. Electrical systems vary and a speaker's technical apparatus such as projectors computers, faxes and phones may not operate on foreign systems. Advance research and appropriate adapters will save embarrassing last minute glitches and insure smooth presentations. Often an extra night of accommodations is warranted as speakers deal with fatigue and time differences.
Most speakers increase their fees for international bookings.
Speakers need to secure the appropriate permits, vaccinations and other necessary documents to work abroad. Each country has specific regulations. Recently I heard a story about a speaker who arrived in Bermuda without a work permit and was turned away. It wasn't possible for the speaker to obtain the permit without returning to the states. Global bookings require special attention.