Reintubations rates were concerningly high for both groups. Used a random-number table and allocation blinded by use of opaque envelopes. Stratified by study center. Of the 484 remaining patients follow-up was complete. The primary endpoint, patients remaining extubated at 48 hrs, was analyzed by intention to treat.
Patients seem similar at baseline.
Both received 2 hour trials and were extubated or not after that time. Depending upon the method used to analyze the primary endpoint of patient remaining extubated at 48 hours the statistical significance varies. In patients tolerating the weaning trial no difference was found in mortality or length of stay. Unfortunately, the authors did not present this data for the original study group - more relevant. One can tease out a probable similar mortality rate, but length of stay is lacking.