The influence of insemination on the implantation of transferred rat blastocysts. Carp, H.J.A., Fein, A., Nebel, L. Effect of Diclofenac on implantation and embryonic development in the rat. The research has led to many fields of investigation. There are cytokines such as IL-2 which retard fetal development. Alternatively NK cells may be produced which may lead to fetal death.
Many cytokines are presently under investigation.
This can be induced by immunopotentiation both in laboratory animals and humans. Immunopotentiation is performed in humans by paternal leucocytes. There is also a passive form of immunization with Immunoglobulin. Immunopotentiation is achieved in laboratory animals by non specific agents such as Complete Freund's adjuvant. 1990 Carp, H.J.A., Toder, V., Gazit, E., Orgad, S., Mashiach, S., Serr, D.M., Nebel, L. Selection of Patients with Habitual Abortion for Paternal Leucocyte Immunization.