Three studies were identified which compared these dosing regimens. All included studies were randomized controlled trials. All patients were between the ages of 0.67 and 12 years. One study was apparently in a controlled outpatient setting, the second involved monitoring by parents at home, and in the third, patients were enrolled in the emergency department, and evaluated either there or in hospital, depending on their disease disposition. One study used rectal temperatures, one used oral temperatures and one used electronic IVAC thermometer temperatures, correlated with oral temperatures.
Results See metaview tables.
Quality Assessment Good quality studies which addressed inclusion and exclusion criteria. Parental temperature monitoring and recording in one study 3 may have produced inaccuracies. Statistics were handled appropriately. Toxicity of ibuprofen vs. acetaminophen . The study was conducted in concert with 1785 pediatricians, family physicians and general practitioners from the continental United States.