Family history of megalocornea may be present. The mother may have slightly enlarged corneas. Autosomal dominant, autosomal recessive, and sporadic inheritance have been reported. Check for excessive mesenchymal tissue in angle. A-scan ultrasound biometry Buphthalmos may indicate congenital glaucoma.
Prognosis is excellent in simple megalocornea.
Patients with anterior megalophthalmos always will be at risk for glaucoma and cataracts, which can be difficult to treat in these patients. Advise parents of the potential for ocular complications and associated systemic conditions. Emphasize the importance of a thorough developmental evaluation and regular medical and ophthalmic follow-up care. The pediatrician should be made aware of the many systemic conditions that may be associated with megalocornea. The cornea in connective tissue diseases.