High power view of a diffuse large cell lymphoma. At this high power, the vesicular nature of the nuclei is clearly seen, with a rim of chromatin near the nuclear membrane and a large amount of pale staining chromatin towards the center.
Many nuclei also contain prominent nucleoli.
Nuclei are separated by each other by abundant pale staining cytoplasm. Towards the center of the left side of this image is a cell undergoing mitosis. These tumors contain predominately large cells, which may have both cleaved and non-cleaved nuclei. The cell of origin is believed to be the centroblast, a cell in the center of the germinal follicle. Medline will open in a new window.