It also seems to work against PI-resistant strains. Human trials of AG-1776 are pending. L-756,423, a chemical cousin to Crixivan, stays in the bloodstream longer, so less drug is required. The potent anticancer drug hydroxyurea works best in combination with ddI , a nuke. Other synergystic combos may be out there waiting to be discovered.
New findings link nukes to everything from lipodystrophy to genetic mutations.
More studies are needed to determine the true extent of these toxicities. Easier to formulate and easier to take than protease drugs. In a word, resistance . A single mutation called K103N creates nearly complete cross-resistance to all the drugs in the class. Target proteins that HIV uses as landing gear to dock on cell surface.