Untitled Document Jpn. KH5 and p-126 MAb may also be useful for protection against dental caries caused by S. mutans .
Passive immunization is safe and specific.
In 3DS, an individual tray that covers the whole dentition is used as a drug retainer. A tray that fits over the tooth surfaces is useful for delivering small but sufficient amounts of anti-bacterial drugs. It is easy to manipulate and maintains high concentrations of MAbs in direct contact with tooth surfaces. Thus, MAbs are not diluted by saliva, and only the bacteria on the tooth surface, but not those on the oral mucosa, are exposed to MAbs. Saliva secreted over a period of 3 min, while being stimulated by biting paraffin gum, was collected into ice-chilled sterile bottles.