It reduces the pain, stiffness, and inflammation associated with degenerative joint problems, i.e. arthritis. SAMe is a methyl donor, and provides an essential portion of the molecule used in producing each of the above-mentioned biochemical processes. While some of these can cause liver damage, SAMe has been shown in numerous studies to actually be liver-protective. It acts more rapidly, most often within a few days. It has no significant side effects.
SAMe has no withdrawal reaction, commonly found with antidepressants.
Numerous clinical studies have shown that SAMe can reduce pain, stiffness, and inflammation associated with degenerative joint problems. When compared to the common anti-inflammatory medications, Naproxen and Ibuprofen, SAMe did an equally effective job in reducing pain and inflammation over a three month period, and without the gastrointestinal damage caused by these drugs. Clinical studies show SAMe works well in countering the fatigue, inflammation and pain associated with fibromyalgia, a puzzling and hard to treat condition. Because of SAMe's effects on the liver, it enhances the elimination of various drugs from the body. SAMe has also been shown to protect the liver and body from the effects of excess and unbalanced estrogen levels, seen in some estrogen replacement therapy, oral contraceptive use, and premenstrual syndrome.