Well-documented human health effects linked to Pfiesteria have occurred in laboratory conditions, where researchers were working with the organism in close proximity and in high concentrations. Researchers there now take strict precautions when working with Pfiesteria . Some who fish in affected waters have reported sores and less specific ailments, such as fatigue and light-headedness. Making a clear connection between generalized symptoms and Pfiesteria can prove difficult. That same study did show that those who fished in Carolina waters exhibited more skin sores than the general population living in the same region.
Research is still underway.
A Maryland water-skier suffered lesions after skiing in the Pocomoke River. Pfiesteria remains difficult. Given the concern raised by the above experiences, it would be prudent not to handle fish with lesions. If it is necessary to handle such fish, one should wear gloves. To be on the safe side, one should avoid swimming or skiing in an area where a fish kill is underway.