If this time is greater than two years then you are pretty safe. How does the companies patent position differ from others in the same industry. If a company has a lousy cash position but a product coming to market, it is not as much of a risk as a company that won't have a product to market for years but has a decent cash position. The statute of limitations on lay-offs is three years according to J.C. Rat. That is not to say you shouldn't go with an employer that has had recent lay-offs, but you certainly should be aware of it.
Most companies have the policy in the handbook, but few people take advantage of it.
Comes in handy for computer training, or if you want to start taking classes for an advanced degree. With success comes lawsuits, esspecially in biotechnology. Many companies give lip service to wanting publications but don't really support it. Ask if there is an incentive program for publications, presentations, and patents. Also, this will allow you to ensure that sound science is behind the company.