The higher the dose or the more times you have been treated for rejection, the more side effects. As the dose is gradually reduces, side effects diminish. In most cases, prednisone can be reduced to a maintenance level by the end of about one year after transplantation. Also, use of combinations of drugs has allowed physicians to prescribe lower doses of prednisone than in the past. Regardless of complications, never stop taking prednisone unless you are instructed to do so by your transplant team.
Many problems can occur if prednisone is stopped suddenly.