In this case, the symptoms may actually get worse. In rare cases, even though the patient avoids all estrogen and changes her lifestyle there is still a treatment failure. In this case, xenoestrogens stored in the body fat or from an recognized source may be considered. The second most common failure seems to be the inability of the patient to absorb Natural Progesterone through the skin. Another obvious reason for treatment failure is the use of progesterone cream that is not formulated correctly.
Mineral oil can block absorption of Natural Progesterone.
The Natural Progesterone cream can have the inappropriate amount of Natural Progesterone, or contain herbs or preservatives that stimulate estrogen receptors and mimic estrogens. Essentially, fibrocystic breast disease is the result of a tug of war between estrogen and progesterone. If too much estrogen is present relative to progesterone, fibrocystic breast disease will worsen. According to the Dartmouth University Study, plastic wrap heated in oil in a microwave oven contained 500,000 times the minimum amount of xenoestrogens needed to stimulate breast cancer cells to proliferate. Heating plastic wrap with food is very bad.