Reported side effects included flushing and mucositis, but relatively little bone marrow toxicity. MGBG also is under study in combination with radiation for patients with primary CNS lymphoma. Camptothecins already have shown activity against lymphomas in people without HIV, but the drugs are very bone-marrow toxic. 13 Other experimental strategies target EBV antigens on the surface of tumor cells. Of course, anti-EBV therapies are unlikely to show activity in lymphomas with no evidence of EBV infection.
Research continues to make only incremental advances in the treatment of the overall condition.
Until effective treatments are found against HIV, the treatment of lymphoma and other AIDS-related malignancies, will continue to be a challenge. Thirty-Fifth Annual Interscience Conference on Antimicrobial Agents and Chemotherapy. Pluda, JM et.al. Journal of Clinical Oncology. Widney, D et al.