Report cases to infectious disease and local health departments. Efficacy of antifungal therapy for coccidioidomycosis often is less certain than for other fungal diseases. Antifungal agents - Their mechanism of action may involve an alteration of RNA and DNA metabolism or an intracellular accumulation of peroxide that is toxic to the fungal cell. Impairs synthesis of ergosterol, allowing increased permeability and leakage of cellular components. Obstruction of pulmonary tissue due to scarring or cavities may occur.
Most cases are self-limited and resolve within a few months.
Prognosis is poor if the patient has a weak cell-mediated immunity or high IgG. Relapse of extrapulmonary or disseminated disease is common. A Treatise of Infectious Processes, 5th ed. A coccidioidomycosis outbreak following the Northridge, Calif, earthquake. Principles and Practice of Infectious Diseases. Medicine is a constantly changing science and not all therapies are clearly established.