Recent medical studies demonstrate that the brain levels of Prozac are 100 times greater than blood levels and it is believed that this is the case with the other serotonin reuptake inhibitors as well - evidence of toxic brain levels affecting behavior no matter what the blood levels demonstrate. This accumulation is evidence that the drug residue will produce a delayed withdrawal and continue to produce reactions, not only during the period of time the patient is using the drug, but for long periods of time after discontinuation of the drug use. Brain wave patterns indicate patients are in a total anesthetic sleep state while appearing awake and functioning.
Patients report over and over again that they have lived out their worst nightmare.
And as with sleepwalk episodes, many have no recall or little recall of what they have done. Often someone must prove to them what they have done while they where under the influence of these drugs before they will believe it to be true. Seven to ten percent of patients do not have the liver function necessary to metabolize these drugs. Stress or depression can be detected by elevated levels of cortisol, yet one single 30mg dose of Prozac clearly doubles the level of cortisol. This should in the long run double the patient's stress and depression.