As long as they are fed, changed and comfortable they will sleep much of the time and allow you to do your own thing.
Many parents consider a reclining stroller indispensable on a trip.
In a pinch, it can also double as a bassinet. Just schedule plenty of time for feeding and changing and do not feel guilty for taking a lot of breaks. Toddlers can be a lot of work on the road, but if you plan according to their abilities everything will run smoothly. Your toddler has a short attention span, so do not expect her to hold up through the entire Museum of Natural History. Take large sights in hour long spurts with breaks for playtime and return later.