Many other problems remain to be solved. The pathogenesis of pituitary adenomas is still enigmatic. Although many studies were undertaken during the last decade the process of neoplastic transformation and subsequent progression is still not understood. The causes, however, responsible for this transformation has yet to be elucidated. The role of hypothalamic stimulating and inhibiting hormones influence the multiplication of the transformed cell.
Much more work is needed to better understand the clinicopathologic correlations.
Advancement in morphologic techniques offers considerable hope that from the structural features of adenoma cells conclusions can be drawn on biologic behavior, growth rate, invasiveness and therapeutic responsiveness. More emphasis should be directed toward the treatment of pituitary tumors. Surgery is the first choice in the treatment of several adenoma types. Removal of the tumor either by transsphenoidal or transcranial route is effective in many patients. If the tumor is totally removed and adequate number of functioning pituitary cells remain behind, the patient can be regarded as cured.