The best time for obtaining a urine sample would be at the end of the shift at the end of the workweek. Creatinine determination is important because the concentration of 2,5-HD depends on urine output. There is no other useful treatment. If the patient is removed from further exposure, the prognosis is usually good. The patient may experience a worsening of symptoms within the first few weeks, but improves afterward.
Recovery usually takes a few months to a few years depending on disease severity.
Recovery in mild to moderate cases is usually complete. Severe cases take longer to recuperate and may not recover completely, possibly experiencing residual muscle atrophy, spasticity, muscle cramps and dyschromatopsia. If the patient continues to be exposed, the neuropathy worsens, ultimately developing into paralysis. Fortunately, death has not been reported in humans. Recommend that the patient inform their employer, if work-related, and provide documentation for medical removal.