Evidence indicates that GLUT4, in insulin-resistant states, accumulates in an alternative membrane compartment from where it cannot be mobilized by insulin to the plasma membrane. The role of small molecular weight GTP-binding proteins and other factors is being studied in the context of trafficking defects. Another important focus of the laboratory is the genetic basis of human diabetes, obesity, and diabetic complications. The laboratory is engaged in a multicenter collaboration for positional cloning of diabetes genes in the Pima Indians. DNA is being collected for genotyping, linkage analyses, and positional cloning in this genetically homogeneous population.
Recent work has involves genes influencing energy expenditure.
Recent Publications Publications in Scientific Journals Lima, F.B., and W.T. Garvey. Dominguez, J.H., K. Camp, L. Maianu, H. Feister, and W.T. Garvey. American Journal of Physiology. Dominguez, J.H., B. Song, L. Maianu, W.T. Garvey, and M. Qulali. The role of diabetes mellitus.