In summer, activity is restricted to mornings and late afternoons. Snakes may be active all year in the southern part of the state during mild to warm weather. Normally snakes are active in spring and early summer with greatest activity occurring in May and June. Clutches average 5 to 6 eggs. The western patch-nosed snake is probably preyed upon by raptors, roadrunners, most diurnal mammalian carnivores, kingsnakes and other snake predators, but no records of predation are known.
Nothing is known about competitors, diseases, parasites or weather.
This species is widely distributed and poorly known. Notes on snakes of the genus Salvadora with a redescription of a neglected Mexican species. Bogert, C. M. 1945. Two additional races of the patch-nosed snake, Salvadora hexalepis. Fitch, H. S. 1970.