Although a new slow-release formulation of fluoride looks promising for prevention of spine fracture, larger studies are needed to prove it safe. Therefore, there are no clinical indications for fluoride use at this time. Prevention and treatment of osteoporosis. Cummings SR, Nevitt MC, Browner WS et al. Risk factors for hip fracture in white women.
Osteoporosis is characterized by an absolute decrease in bone mass of normal morphology.
Osteomalacia is characterized by decreased mineralization of bone matrix, but normal bone volume. High protein intake is a risk factor for osteoporosis. Densitometry may be useful at a decision regarding hormone replacement in postmenopausal women. Indications for bone densitometry include asymptomatic primary hyperparathyroidism. Disadvantages of CT densitometry include its' high radiation dose and poor reproducibility.