It has a mild laxative effect and stimulates the lymphatic system and has shown benefit in skin related problems. The fresh plant or juice is used as a medicinal poultice for wounds, ulcers and many other skin problems . An infusion of the herb has shown of benefit in the treatment of glandular fever, tonsilitis, hepatitis and cystitis. The infusion is also used to treat liver, bladder and urinary problems. The plant contains the valuable constituent asperuloside, a substance that is converted into prostaglandins by the body.
Prostaglandins are hormone-like compounds that stimulate the uterus and affect blood vessels.
Much more scientific research is being done on the plant it is of great interest to the pharmaceutical industry. Also used as a hair tonic, said to be good for the hair, making it grow long. Several Native American Tribes used an infusion of the plant for gonorrhea. A red dye is obtained from a decoction of the root, it is said to dye bones red. It was also believed to remove freckels.