The instruments themselves are visually whimsical works of art incorporating driftwood and glass gongs and aircraft parts. This challenges our concept of what music really is. I wish the Synclavier Zappa used for his impossible music had been available before Harry Partch passed away. Often overlooked are the pioneers of electronic music like John Cage, Morton Subotnick and the still innovative Karlheinz Stockhausen. But I can't say that these extremes will much alter the pop music of tomorrow.
Most ears remain unsophisticated and set in their ways.
The timbre will change, that's an absolute. The tonality may not. There is still beauty and comfort in hearing a virtuoso Lute Allemande from 1512, in my small book anyway. Folk music is hear to stay.