Trauma and ocular injuries, such as chemical splashes, often can be avoided by the use of protective eyewear. Most of the time, factors that lead to Descemet folds cannot be prevented such as infections and inflammatory conditions. Central corneal scarring also may result depending on the location of the underlying corneal infection or injury. Usually, the Descemet folds resolve with the resolution of the ocular inflammation. Depending on the duration of the corneal edema and folds, there may be residual corneal scarring after the edema and folds resolve.
Patients usually have a good prognosis unless central corneal scarring results.
Once the inflammation is treated, the corneal edema and Descemet folds typically resolve. They may find it difficult and tedious to instill the drops as frequently as usually is prescribed. Also, the patient needs to understand that gradual improvement will occur in the inflammation and Descemet folds, which results in gradual improvement in their vision. It is important to inform the patient that the treatment of the underlying cause for the inflammation is of the utmost importance. The treatment relies heavily on the patient's medical compliance with the topical drop regimen.