In combination with the vital dye propidium iodide, it was shown that apoptotic cells expose PS while maintaining their plasma membrane integrity. Death receptors 6-1. TNF gene superfamily . TNFR1 signaling TNF macrophage T cell . TNFR1 signaling CD95 signaling .
Proteolysis is irreversible, unlike most posttranslational modifications.
Most proteases are synthesized as precursors that have little, if any, catalytic activity. - usually activated by proteolytic processing Proteases can regulate their own activation. Proteolytic reactions can be specific. 6 antiparallel alpha-helices 3 . I CAD cleavage CAD DNA . But it protects poorly against apoptosis of lymphocytes induced by ligation of the receptor CD95.