I don't follow subjects to see what the effects of treatment are, but the renewal application asks how many subjects I have enrolled to date. I've been doing these studies for 12 years here. The same minor irritations occur year after year. Suggestion I don't know enough about the internal processing of applications to answer this question. The paper work appears to be a little too much and I never seems to be able to complete a form and process at the first attempt.
Minor details appear to be the problem.
Suggestion F Problem Hu. Too many precise instructions required are totally impractical to send to many research participants. There appears to be little trust that the PI is ethical. Asking for verbatim phone accounts is absurd. One has to go with what the participant seems to be needing, i.e. more information about the study, etc.