This laboratory seeks to understand the molecular mechanisms of neurotoxicity of environmental toxicants directed toward targets within both the neuronal cell body and the axon.
Related studies seek to define the toxicity of dithiocarbamate and isothio-cyanates.
In addition, the pathogenesis of degenerative diseases, such as atherosclerosis, Parkinson's disease, and Alzheimer's disease, receives contributions from genetics, aging, and exposure to environmental toxicants. Our studies on Parkinson's disease focus on the toxicity of catechols, transition metals catalysis of catechol oxidation, and the relative contributions of arylation and redox cycling in cytotoxicity. Member, Scientific Review Panel for Health Research, Environmental Protection Agency, 1985-1987. McGraw-Hill, New York, pp. Toxic responses of the nervous system.