Platelet Prostaglandin Metabolism Aspirin inhibits thromboxane synthesis by irreversibly acetylating the cyclooxygenase. It binds to GPIb on platelets.
Plasma fibrinogen is required.
GPIIb-IIIa complex on platelets plays a role. The contribution of platelets to the coagulation cascade. Activation of several of the coagulation proteins occurs on the platelet surface. Gammaglobulin Danazol Platelet transfusions are indicated for life threatening and serious hemorrhagic episodes. Thrombotic Thrombocytopenic Purpura A fulminating, often lethal disorder.