Well absorbed from the GI tract and widely distributed in body tissues. CSF levels are similar to those in plasma. With other drugs to treat active pulmonary and extrapulmonary tuberculosis only when primary therapy cannot be used. To treat UTIs when other therapy has failed or if the organism has demonstrated sensitivity. Hypersensitivity to cycloserine, epilepsy, depression, severe anxiety, psychosis, severe renal insufficiency, and alcoholism.
Neurotoxic effects depend on blood levels of cycloserine.
Hence, frequent determinations of cycloserine blood levels are indicated, especially during the initial period of therapy. Charcoal may be more effective than emesis or gastric lavage. Hemodialysis may be used for life-threatening toxicity. Pyridoxine may treat neurotoxic effects.