Manufacturers will have to be contacted in each case. DOS and Windows programs have to be fixed. Windows 95 and up is ok. See the Microsoft website for directions. A similar situation probably holds for Apple as well.
Problems can lurk in hardware, software, or applications programs.
For example Excell or other spreadsheet macros might be a problem. Departments and research centers should check their systems. The place to begin is to find out what programs on what machines are being used for what purposes. There are standard methods for the whole process. In small organizations the problems may be minor, but the assessment process can be used to learn about and improve the organization's use of information technology.