Gene expression profiling and bioinformatics approaches to the identification of novel signaling pathways critical for cellular homeostasis and design of targeted therapeutics. ISOM, Lori L. , Ph.D. Associate Professor. Cellular and molecular biology of voltage-gated sodium channels. Molecular control of sodium channel density and localization in myelinated axons. Functional modulation of sodium channels by extracellular matrix proteins and cell adhesion molecules.
Projects combine molecular and cell biological techniques with biochemistry and electrophysiology.
Mechanisms of free radical mediated tissue injury and the regulation of hemoprotein enzymes, such as nitric oxide synthase and prostaglandin synthase. Interaction of steroid receptors and protein kineses with heat shock proteins and immunophilins. Metabolism and mechanism of action of nucleoside analog anticancer compounds. Role of 1,25 Dihydroxy -Vitamin D3 in cell differentiation and cell proliferation. We are interested in the mechanism of action of this hormone and its action to regulate gene expression.