Discussions Here are the top 10 topics visitors are searching. Heart Disease 8. Medroxyprogesterone is a semisynthetic compound that differs in structure from the naturally occurring human hormone progesterone . It is added to estrogen replacement therapy to prevent uterine cancer caused by unopposed estrogen.
Medroxyprogesterone is available alone and in a combination product.
An injection product is used for contraception. In a group of 37 postmenopausal women treated with conjugated estrogens and medroxyprogesterone for 12 months, urinary zinc and magnesium loss was reduced in those women who began the study with signs of osteoporosis and elevated zinc and magnesium excretion. The clinical significance of this interaction remains unclear. In a one-year study of predominantly malnourished women in India and Thailand, medroxyprogesterone used for contraception was associated with increased blood levels of vitamin A and folic acid . The clinical meaning of these changes remains unclear.