I am a singer. The muscles in the throat are so delicate, they are like onion skins. So, the whole issue of keeping them moist is the first thing. The second is how hard you use these delicate structures. Breathing patterns , alignment and straining are all big issues.
Many singers tend to jut their head and jaw forward and to push for intensity and volume.
But those things can be counterproductive to long-term performance. I play guitar. Unfortunately they often learn those licks sitting around on a couch, which causes lots of bad posture and alignment problems. This is how injuries occur. Also, an electric guitar is heavy and if its strapped across a shoulder for hours at a time, it's going to cause nerve compression and blood vessel compression in the neck and shoulder.