Occurs in children, usually under age 5. Peak incidence between ages 1 and 3. At the time of detection, Wilms tumors are usually large and dwarfs the native kidney. The cut surface is usually soft, fleshy and brain-like. Irregular areas of hemorrhage and necrosis may be present.
Mitotic figures are usually plentiful.
The clinical presentation is that of a large abdominal mass in a child, usually 1 to 5 years old. The neoplasm is aggressive and metastasizes widely, but is responsive to combination therapy. Robbins Pathologic Basis of Disease. Search Medline at National Library of Medicine Please be patient during transfer. Medline will open in a new window.