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Refuge is located at the mouth of the Mississippi River.
The subheadquarters is located in Venice, LA, on Highway 23 south. Delta NWR supports a wide variety of wildlife species. Tens of thousands of wintering waterfowl take advantage of the rich food resources found in the delta. Large numbers of other bird species can be found on the refuge, with numbers peaking during the spring and fall migrations. Large numbers of wading birds nest on the refuge, and thousands of shorebirds can be found on tidal mudflats and deltaic splays.