A major line of research in the laboratory deals with the Notch signaling system. A critical step in Notch signaling is a ligand-induced cleavage of the Notch receptor and translocation of the intracellular domain to the nucleus. Second, mutations in presenilins, which are critically involved in early onset Alzheimer's disease, affect the intracellular processing of Notch receptors. In the seminar, data will be presented on differences in receptor function between Notch 3 and other Notch receptors and transgenic approaches to understand Notch function in development and disease. Development 126, 3925-3935.
Notch signalling controls pancreatic cell differentiation.
Notch and neurogenesis. Journal of Neuroscience Research 54, 125-136.