We believe that by taking a mechanistic approach to better understand the pathways by which these agents exert their anti-proliferative effects, we can identify the key molecular signaling events which are essential for this process and develop better and more specific therapeutics for the treatment of colorectal cancer disease. In addition, our laboratory recently has identified that two key differences in cAMP-related signaling molecules exist between neoplastic and normal colorectal tissues. These differences may not only serve as potential therapeutic targets for chemotherapeutic agents, but also may lead to the identification of novel regulatory mechanisms involved in cell proliferation and tumorigenesis. Selected Publications Chris C. Carlson, Stacy L. Smithers, Karen A. Yeh, Laura L. Burnham and Daniel T. Dransfield.
Protein kinase A regulatory subunits in colon cancer.
P. Henry Schmidt, Daniel T. Dransfield, Jaime O. Claudio, Robert G. Hawley, Kevin W. Trotter, Sharon L. Milgram and James R. Goldenring. A Multiply Spliced A-Kinase Anchoring Protein Associated with Centrosomes. Rebecca Chinery, Jeffrey A. Brockman, Daniel T. Dransfield and Robert J. Coffey. Daniel T. Dransfield, Jennifer L. Yeh, Alvin J. Bradford and James R. Goldenring. Daniel T. Dransfield, Alvin J. Bradford, Jenetta Smith, Marianne Martin, Christian Roy, Paul H. Mangeat and James R. Goldenring.