A view of a liposarcoma at high power. Typical of this tumor are cells that represent different levels of accumulation of lipid, as indicated by the cells at the tips the black pointers. Some cells lack any obvious lipid, whereas others demonstrate a clearly fenestrated appearance of the cytoplasm, indicating the presence of numerous droplets of lipid. In addition, this tumor is characterized by bizzare, or often multi-nucleated cells, such as the cell under the green pointer. Tumor of adult life, with a peak incidence between 40 and 60 years of age.
Retroperitoneal tumors occur somewhat more frequently in women.
There is no evidence that any race or geographical area is more prone to develop liposarcomas. The three most common locations are the thigh, the retroperitoneum, and the inguinal region. Liposarcomas typically manifest a lobulated appearance. Cut section may reveal a mucinous appearance, especially if the myxoid component is prominent. Typically, at least some evidence of yellow color, due to the lipid material, is present.