Distinct functions of SR proteins in alternative pre-mRNA splicing. Distribution of pre-mRNA splicing factors at sites of RNA polymerase II transcription. Smg mutants affect the expression of alternatively spliced SR protein mRNA in C. elegans .
SR proteins are sufficient for exon bridging.
Growth, Differentiation And Alternative Pre-mRNA Processing. In my lab we use primarily cell biological approaches to study several basic biology problems. Unlike unicellular organisms which always grow to a certain size and then divide, the cells of metazoans sometimes grow without dividing and at other times in development divide without growing. Mutations in the ncl-1 gene were identified because most of the cells contain enlarged nucleoli. While the number of cells is not changed in the mutants, the cells are bigger and the animals are bigger than wild type.