RNA will be isolated. Experimental confirmation of predictions would involve the use of specific 'pull down assays'. This would be followed by a streptavidin bead 'pull down', RT and sequencing. In this case a cell RNA specific probe should also pull down viral sequences. If dsRNA is isolated and characterised, further experiments relating its presence to affects on cognate mRNA-protein expression would be designed.
Many viruses contain homologues of cellular genes.
A more targeted approach would test if ds RNA transcripts corresponding to these, demonstrate RNA interference of the cellular product. In either event, further questions would be concerned with the mechanism 1. The views expressed in this document are those of the document owner. If you are an authorised user you may edit this document through your Web browser.