TNF gene superfamily . TNFR1 signaling TNF macrophage T cell . TNFR1 signaling CD95 signaling . Proteolysis is irreversible, unlike most posttranslational modifications. Most proteases are synthesized as precursors that have little, if any, catalytic activity. - usually activated by proteolytic processing Proteases can regulate their own activation.
Proteolytic reactions can be specific.
6 antiparallel alpha-helices 3 . I CAD cleavage CAD DNA . But it protects poorly against apoptosis of lymphocytes induced by ligation of the receptor CD95. Bcl-2 cell cycle inhibitory effect . 10. corpse clearance 10-1.