Most cells undergo a degenerative process indicative of apoptosis and are deleted before ovulation.
There was a positive relationship on Day 2 between level of ovarian progesterone and immunostaining of ADP-ribose polymers in surface epithelial cells associated with the ovulatory site. Evidence of DNA fragmentation or PARP activity in control cells was low and not affected by time of sample collection or treatments. The progesterone receptor antagonist RU486 and the transcriptional inhibitor actinomycin D blocked increases in PARP in ovarian surface epithelial cells incubated with progesterone. Journal of Endocrinology Download the FULL TEXT of this article in Acrobat PDF format. If you have not previously downloaded PDF files we suggest you access our Advice page for further information.