The Section on Structural Cell Biology uses advanced microscopy imaging in combination with molecular and cell biology techniques to study mechano-sensory transduction in auditory and vestibular sensory organs. Belyantseva IA, Adler H, Cury R, Frolenkov G, Kachar B. Expression and localization of prestin and sugar transporter GLUT-5 during development of electromotility in cochlear outer hair cells. Azzam N, Hallenbeck J, Kachar B. Membrane changes during hibernation.
Organelle lipids undergo rapid reversible rearrangements as body temperature drops.
J Struct Biol 131, 67-78, 2000. Mutations in the gene encoding tight junction claudin-14 cause autosomal recessive deafness DFNB29. Lagostena L, Ashmore JF, Kachar B, Mammano F. Purinergic control of intracellular calcium and gap junction communication in supporting Hensen s cells of the guinea pig cochlea. The motor and tail regions of myosin XV are critical for normal structure and function of auditory and vestibular hair cells. Hu P, Deng F, Liang F, Hu C, Auerbach A, Shapiro E, Wu X, Kachar B, Sun H. Ablation of uroplakin III gene results in small urothelial plaques, urothelial leakage, and vesicoureteral reflux.