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Migration is believed to be influenced by various neural glycoproteins or fibres.
Why in Hirschsprung's disease this migration does not occur is not known. The role of NCAM - Neural Cell Adhesion molecules is being investigated, as they appear to be reduced in patients with Hirschsprung's disease. Some have also suggested a possible immunologic mechanism. A deletion in the chromosome 10 has also been postulated as a cause for Hirschsprung's disease. The gross features vary with the duration of the disease.