This is a type of lymphoma characterized by a proliferation of small lymphocytes producing a monoclonal IgM gammopathy. It is a clinical-pathologic syndrome often associated with a hyperviscosity syndrome.
Patients usually present with fatigue, weight loss and bleeding problems.
Lymphadenopathy and organomegaly is commonly present. Of 12 cases with chromosomal abnormalities, a single numeric abnormality was present in 4 and a complex karyotype in 8. Clinical follow-up was available for 28 patients for a median of 36 months. Year Survival Median survival of 5 years after diagnosis Treatment Chemotherapy with alkylating agent Hyperviscosity May be treated with plasmapheresis Atlas of Tumor Pathology-Tumors of the Bone Marrow. Volume 9, Third Series.