In this appendix a list is given of some of the most important diseases. In some cases an explanation is found for these disorder diseases. A medical solution was found seldom. Thin atrophic corrugated scars after even minor trauma, Pseudotumors in skin, Varicose veins, Hyper extensible joints leading to osteoarthritis, Reversal of the spinal curves. Unknown defects of collagen or other matrix proteins contribute to abnormal collagen fiber formation.
Patients use supportion and have to build up strong muscle mass to protect joints.
Ehler-Danlos type II Same as type I, but fewer of them and less severe. Asymptomatic except for pain, rarely dislocation of joints in sports, Symptoms present in 20s and 30s, Joints laxity. Mutation within the type III collagen gene that result in production of a defective collagen molecule, the effect of the mutations are analogous to those in type I collagen that result in Osteogenesis Imperfecta. Perhaps an abnormality of copper metabolism. A consequence of low hydroxylysine level is altered cross-linkage of collagen within bone.