Intramuscular injections should be given with care in patients suffering from coagulation disorders because of the risk of haemorrhage. If Tripacel is used in persons with malignancies, receiving immunosuppressive therapies, including irradiation, antimetabolites, alkylating agents and cytotoxic drugs, who are otherwise immuncompromised or on corticosteroid therapy, the expected immune response may not be obtained. The product must not be mixed with other vaccines in the same syringe. A few cases of peripheral neuropathy have been reported following tetanus toxoid administration, although a causal relationship has not been established. Persistent nodules at the site of injection have occurred following the use of adsorbed vaccine, but this complication is unusual.
Most convulsions are brief, generalised and self limited, and are usually associated with fever.
Neither febrile nor afebrile convulsions have shown to be associated with subsequent seizure disorder. Use in pregnancy. Use in lactation. Adverse Reactions Clinical trial data. Table 2 shows rates of reactions observed in this trial within 48 hours of vaccination.