Inhaling for an extended time from a bag or balloon may cause a dangerous shortage of oxygen in the lungs. The risk of SSD seems to be higher if the abuser engages in strenuous physical activity or is suddenly startled. Repeated use tends to produce increased tolerance to the drugs and larger doses are needed to achieve the same results. Heavy doses in turn increase the risk of permanent brain damage, with effects such as poor memory, extreme mood swings, tremors, and seizures. Heavy, continuous use also increases the risk of heart arrhythmia and respiratory depression.
Nitrite inhalants tend to raise the pressure of the fluid within the eyes.
The raised pressure may eventually lead to glaucoma and blindness. Regular nitrite abuse may also cause severe, pounding headaches. Organic solvents are the most dangerous of all inhalants. They are poisons that break down organic compounds of all kinds including those that make up living cells. Once absorbed into the body, they tend to concentrate in the liver and kidneys, where they are processed for disposal.