In other words, keep it simple. You may want to start with a front page to direct readers to different parts of your content, then have a number of secondary pages which contain the gory details of your site. Find sites on the web that are similar to your idea, and look at how they're organized. If you're planning on making a large site, you may want to draw an outline or a diagram to decide how your content will flow through your site. Once you have the general layout done, you should come up with a design for individual pages.
Most sites benefit from uniform design across many pages.
This method is especially easy for you, the author, since you only need to create one basic design and slightly alter it for each page. Even large sites like CNN use this principle of design, though it's valuable on any scale. Again, take out a piece of paper or your favorite desktop publishing program. This time, draw out a general mockup for your site. Be sure to include room for a menu of some sort, perhaps with links to the major topics of your site.