Natural resistance seems to be controlled by a genetic determinism.
A F1 crossbreeding plan is in progress to study the genetic transmission of the identified markers and field validations are developed in other bovine breeds. The effect of DRB3.2 alleles on TB has been estimated by multiple regression models. No significant genetic effect on g-IFN secretion has been recorded. The analysis of keyhole limpet haemocyanin presentation did not show any difference between these lines. No relationships were found between lys-mic genotypes and analysed parameters potentially connected with mastitis resistance or susceptibility.