New results show genetic risk linked to inflammatory loci.
Because ibuprofen was the single largest contributor to protection in several large epidemiological studies, we tested the impact of 6 months dietary high dose ibuprofen on the development of neuritic plaque pathology in transgenic mice expressing the human APPsw AD gene. We found that ibuprofen suppressed both the inflammatory and neurodegenerative response to amyloid. In the same transgenic model, we have also found that a dietary anti-inflammatory antioxidant with low toxicity can lower the overall amyloid burden, reduce oxidative damage and limit neurodegeneration. Supported by NIH AG13471, VAMC Merit Review and Alzheimer Association. Copyright 2001 World Events Forum, Inc.