Meclizine is structurally and pharmacologically similar to buclizine and cyclizine.
Meclizine is used in the prevention and treatment of nausea, vomiting, and dizziness associated with motion sickness. Additionally, it has been used in the management of vertigo in diseases affecting the vestibular apparatus. However, the efficacy of meclizine in these conditions has not been established. While prophylactic use of meclizine is most effective in the treatment of motion sickness, other factors such as patient age, and type, severity, and duration of motion influence its effectiveness. It has been suggested that meclizine causes fewer anticholinergic effects than scopolamine.