Most granulomas are relatively small.
When a single mass larger than 6 cm in diameter is being considered, the differential diagnosis changes enough to warrant a separate category. Moreover, the differential diagnosis for large infectious masses and noninfectious, nonneoplastic masses is unlike that for small nodules. If the bronchi associated with an anaerobic lung abscess are occluded, pus cannot escape and air cannot enter. Hence, the abscess may produce a homogeneous, round mass. Cryptococcal infection can produce a solitary mass up to 10 cm in diameter, often with few inflammatory symptoms.