The difference in response was based in the difference of their experience with Jesus. Because the people in Nazareth knew Jesus from childhood, knew Mary and Joseph, they could not imagine or see him in a new light. From the text it seems that they wanted him to perform a miracle. If he could do that then perhaps he was who he said he was. But Jesus didn't or wasn't able to perform a miracle upon demand.
Miracles are interesting happenings.
They defy logic. They are not predictable. While Jesus did heal some, he did not heal all. Those who have been touched by miracles say the same things now that those who received them when Jesus performed them as reported in the Gospel accounts. They are responses of praise to God.