This syndrome is associated with hypoalbuminemia, hyperlipidemia, and edema. Atypical presentations with acute renal failure, severe hypertension, hematuria, and hypocomplementemia suggest another renal parenchymal disease. A. Mild cases are asymptomatic with less proteinuria than found in nephrotic syndrome.
Moderate cases have nephrotic syndrome with or without hematuria.
B. Hypoalbuminemia can cause severe edema, ascites, pleural effusions, and hypovolemia with azotemia. When hypovolemia results in hypotension, do riot use furosemide. When decreased renal profusion is contributing to hypertension, establish urine output with furosemide and then consider an albumin infusion. During the third month of therapy, taper the dose by 5 mg every 2 weeks. Monitor proteinuria daily with an albumin-sensitive dipstick.