About two-thirds of the yeast genes exhibit a similarity to human genes. Applying the method developed for analyzing transcription factors in humans will prove to be powerful, he explains. Snyder's laboratory has pioneered many new chip technologies. Protein chips are disposable arrays of microwells in silicone sheets placed on top of microscopic slides. In a study published in the November issue of Nature Genetics, Yale researchers overexpressed nearly all of the yeast protein kinase and analyzed them using 17 different substrates and protein chips.
Protein kinases are key regulatory molecules that control many biological processes.
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