That's what lawyers are for. The city is becoming a battleground. Two species of werecreatures are asserting dominance for control of the city. Gangs of weres are roaming the city by night, leaving the citizens alone but getting into horrible conflicts whenever conflicting were groups cross paths. The characters may try to stop the violence, may be convinced to help one side or the other, or may try to mediate the conflict.
Possibilities are extensive.
A handful of ninjas are roaming the city, breaking into city offices at night, including the Department of Motor Vehicles. They are searching for an outcast from their clan named Jitsu. He is now a small-time supervillain who has just moved to Mayfair City. The ninjas want to capture or kill him for their lord. If players have a hard time tracking the ninjas, they can run across a skirmish between them and Jitsu.