To approach this, the major sites of autophosphorylation of Jak2 have been identified, as they may recruit key substrates. To explore the roles of these two pathways, mutant mice are being developed. Moreover, erythropoiesis is overtly normal. However, a number of specific defects identify signaling pathways that require PLC- g 2. Finally, the reproductive traits of both males and females fail to develop properly.
Ongoing studies continue to define the biochemical consequences of cytokine signaling.
Additional approaches are being used to identify proteins recruited to cytokine receptor complexes. Our primary mechanism of assessing function continues to be the derivation of mutant mice. These mice not only allow the identification of nonredundant functions of genes but also are used in crosses with other mutants to explore redundancies. This information is providing insights into the basis of genetic disorders as well as identifying potential therapeutic targets and assessing the consequences of their inhibition. These approaches are also identifying genes whose altered function or regulation contributes to cancer.