There does not seem to be an age, sex, race, or human immunodeficiency virus risk factor predisposition. The most frequent presentation is in patients with cytomegalovirus disease and neutropenia caused by ganciclovir therapy. Lesions developed at the site of occlusive dressings for an indwelling intravenous catheter site in 10 patients. Neutrophil counts may be normal at the time of diagnosis. A minor presentation is in the patient without neutropenia as a result of traumatic inoculation.
Patients develop cutaneous lesions despite prophylactic therapy with fluconazole.
Lesions can be treated with excision and lifelong therapy with itraconazole. Conclusion Because of the potential morbidity and mortality of cutaneous aspergillosis, a high level of suspicion and prompt institution of therapy is required. Accepted for publication June 29, 1999. All rights reserved.