X. Minocycline 1. It interacts synergistically with rifampicin. There are only anecdotal reports of the successful use of minocycline to treat staphylococcal infections, including MRSA endocarditis. Novobiocin and Coumermycin 1. Its mechanism of action is that it inhibits bacterial DNA gyrase activity.
Resistance emerges with single drug use.
Coumermycin Is another coumarin derivative with affinity for DNA gyrase. An intravenous preparation has recently been developed. Successful treatment has been reported in a few patients with bacteraemia. Resistance emerges when the drug is used alone. Clinical trials of streptogramins for staphylococcal bacteraemia in humans are under way.