Alcohol consumption, gross obesity, and diabetes are aggravating factors to hepatic toxicity. May have nausea, vomiting, abdominal cramps. Serious side effects are bone marrow toxicity, alveolitis, and hepatic fibrosis. Monthly CBCs and liver enzyme studies every 2 to 3 months are recommended. Persistent elevation of liver enzymes or significant hypoalbuminemia may indicate the need for a liver biopsy.
Nausea is the main limiting factor.
Monthly CBC and quarterly liver function tests are recommended. The concomitant use of allopurinol increases toxicity and should be avoided. Dosage should be reduced if renal impairment is present. All rights reserved.