Extensive literature has been accumulated on the treatment of Lupus nephritis and a variety of opinions are held regarding the best and safest approach to the therapy. A patient with Lupus Nephritis presents a complex therapeutic approach. Treatment of Lupus nephritis is prolonged, complex and potentially toxic. However, prognosis and outcome of the disease can usually be improved dramatically by treatment. The question of when to stop treatment of Lupus nephritis is often asked.
Renal failure supervenes usually within the first decade of follow-up.
A proportion of Lupus nephritis patients in endstage renal failure still require immunosuppression. Finally, recurrence of Lupus nephritis is renal transplant cases is rare. It appears that maternal morbidity is substantially reduced if conception takes place when the disease is in remission. Lupus nephritis may present during pregnancy and, if this is the case, Lupus is usually severe. This exacerbation during pregnancy may be wide-ranging, causing increased proteinuria and leading to renal failure.