Intermediates in the degradation of abnormal globin. Bestatin permits the accumulation of the same peptides in cell-free extracts as in intact reticulocytes. Role of amino acylation of histidyl-tRNA in the regulation of protein degradation in Chinese hamster ovary cells. Protein synthesis and degradation during growth. Faster protein degradation in response to decreased steady-state levels of amino acylation of tRNAHis in Chinese hamster ovary cells.
Peptide intermediates in the degradation of cellular proteins.
Bestatin permits their in vivo accumulation in mouse liver, but does not affect the degradation of endocytized asialoglycoproteins. Role of protein degradation in the regulation of cellular protein content and amino acid pools. Effects of inhibitors of protein degradation on the rate of protein synthesis in Chinese hamster ovary cells. Role of bestatin-sensitive exopeptidases in the intracellular degradation of hepatic proteins. A regulatory mechanism in mammalian cells responds to deacylation of tRNA and ribosomal idling.