We are interested in the physiology and molecular genetics of this process in the hope of gaining an insight to how they persist in the human body during disease. Wu, G., Williams, H.D., Zamanian M., Gibson, F. and Poole, R.K, 1992. Letters 112 . Genetics Figure 5. A dehisced unordered octad from the fungus Ascobolus immersus , showing segregation of white and granular .
Research here is concerned mainly with the mechanisms and controls of recombination in eukaryotes.
The precise mechanisms by which genes on one chromosome recombine with those on the homologous chromosome at meiosis are poorly understood. We have discovered several series of genetic conversion control factors which affect the conversation properties of target white loci in quite different ways. We use complex crosses, with different conversion control factor alleles, to study how they cause gene conversion and crossing-over to vary. Our theoretical studies identified nine crucial variables in gene conversion, and we produced a large series of equations relating these variables to detectable gene conversion classes. We then developed an iterative computer program to find the best-fitting sets of values for each variable.