The urticarial eruption of SS is typically very resistant to treatment. However, no treatment is consistently effective. Skin and extracutaneous manifestations respond poorly to H1 and H2 antihistamines. Colchicine and dapsone have been tried with variable success in different patients. IV Ig indicated no response.
Recurrence is common with attempts to taper the dose of prednisone.
The goals of pharmacotherapy are to reduce morbidity and prevent complications. In addition, these agents modify the body's immune response to diverse stimuli. May decrease inflammation by reversing increased capillary permeability and suppressing PMN activity. Sulfasalazine, steroids, and immunosuppressive agents are sometimes used. Inhibits inflammatory reactions and pain by decreasing prostaglandin synthesis.