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Repetitive Strain Repetitive strain injury, or RSI, is a condition caused by repeatedly putting your body in positions that cause unnecessary stress. Slouching, improper lifting and poor sleeping positions can all lead to its development. All of these activities cause irritation and damage to tendons, muscles, nerves and other soft tissues. It's no secret that people have more problems in their muscles, joints, bones and nervous system as they age. But what isn't widely shared is the reality that not every ache and pain we feel as we age is inevitable or untreatable.