The treatment or prevention of nausea and vomiting of various causes. If agents such as sedatives, narcotics, anesthetics, tranquilizers or alcohol are used either simultaneously or successively with trifluoperazine, the possibility of an undesirable additive depressant effect should be considered. Precautions Clinical experience has demonstrated that trifluoperazine has a wide margin of safety. Care should be exercised in treating elderly or debilitated patients as some appear prone to neurological adverse reactions.
Phenothiazines can produce alpha-adrenergic blockade.
Because hypotension has occurred, large doses should be avoided in patients with impaired cardiovascular systems. If hypotension occurs, place patient in head-low position with legs raised. If a vasoconstrictor is required, norepinephrine or phenylephrine is suitable. Trifluoperazine therapy may produce an increase in mental and physical activity. In certain instances, this effect may not be desirable.