The practical application of human gene therapy delivered by cationic liposome vehicles has been limited by insufficient transgene synthesis. Our group is working toward identification of the key regulatory events in intracellular plasmid delivery and processing. We use our results to design and test specific, directed modifications of the gene delivery process for optimization of transgene synthesis. Understanding the cellular roles in vascular disease and post-angioplasty restenosis is critical to the development of successful clinical interventions. The relatively uncontrolled conditions of most in vivo studies, however, often leads to difficult interpretation of the measurements obtained by these techniques.
Mitosis activates transgene expression of plasmid delivered by cationic liposomes.
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