The active metabolites are further metabolized by hydroxylation and conjugation and are primarily excreted in the urine. Dosage adjustment is not recommended for patients with renal or hepatic insufficiency. Advise physician before taking this medicine if pregnant or breast feeding. This medication is not intended for everyone who wants to lose weight. This medication can help control obesity, but it does not cure it.
Most people gain weight when sibutramine is discontinued unless eating behaviors are changed.
Cerulli J., Lomaestro BM, Malone M. Update on the pharmacotherapy of obesity. National Task Force on the Prevention of Obesity. Long-term pharmacotherapy in the management of obesity.