The infection is an itchy miserable condition with cheesy discharge. Treatment is with cell membrane acting antibiotics such as Gynelotrimin or Monostat which are just drug company names for the polyene cell membrane acting drugs . Cryptococcus yeast causes a very serious meningitis. The virulence factor of cryptococcus is its capsule which is antiphagocytic. Cryptococcus is transmitted most commonly through pigeon droppings , scattered in air dust.
Respiratory symptoms begin first, then the yeast gets into brain lining.
The inflammatory reaction is serious and the infection is often fatal. Cryptococcal meningitis is hard to treat, so it is very serious. Diagnosis is with a negative stain looking for the capsule in CSF of suspected cases. This fungal microbe used to be called a protozoan. Pneumocystis infection were rare until AIDs.