Liver Kidney 4. If so, list the most affected tissue and the severe pathologic finding present. It induces coagulation necrosis and cell swelling in the liver and kidney. Tumor biologists have shown it is a potential chemotherapeutic agent as it induces apoptosis in certain tumor cell lines. Propose a mechanism that would explain how the same chemical could induce both necrosis and apoptosis in different cells.
Many reasonable answers are acceptable.
The effects could also at least in part by dose-response effects as by dose response effects. That is, a low dose induces small changes in bax release from mitochondria to upregulate apoptosis. Whereas at high doses, the chemical markedly disrupts membranes and proteins through free radical effects.