Ischemic heart disease, pulmonary hypertension, cystic fibrosis, and tuberculosis were excluded. The patient had a respiratory infection, loud second heart sound, digital hypocratism, and arthritis of the proximal interphalangic joints and knees. While hospitalized, she developed polyradiculoneuritis. She had anemia, leukopenia, and hypogammaglobulinemia and did not have isoagglutinins, rheumatoid factor, antinuclear antibodies, anticardiolipin antibodies, anti-HIV antibodies, or antibodies against common microorganisms. HLA homozygosity was for A25, B18, and DR2.
Patients are prone to infection and have a high incidence of neoplasms.
A classic complement pathway is necessary for immune adherence and to generate the C3 split products that influence lymphocyte functions. Faulty complement activation may allow deposition of complexes on lymphocytes, which could interfere with normal co-stimulatory molecules. 14080 References 1. Seligmann M, Brouet JC, Sasportes M. Hereditary C2 deficiency associated with common variable immunodeficiency. Ann Intern Med.