Schistocytes secondary to mechanical trauma. Patients with TTP are usually adults with neurologic and mild renal abnormalities. There may be fever. Schistocytes and severe thrombocytopenia are classic.
Neurologic abnormalities are absent.
Fibrin and platelet deposition are primarily seen in the microvasculature of the kidney. Schistocytes and severe thrombocytopenia are classic. Again PT and PTT studies are normal. HUS is associated with infection, especially E. coli which produces verocytotoxin. Fibrin-platelet thrombi in glomerular and interstitial vessels.