Photo-activated antibiotics, on the other hand, are virtually harmless in dark but they are converted into active form in desired location by laser irradiation of appropriate wavelength. Such approach permits dual selectivity since the simultaneous presence of both photo-activated drug and light is required, so ideally the healthy regions of the system will not be affected. Our current project is directed toward design, synthesis, and investigation of photochemistry of photo-activated analogs of natural enediyne antibiotics. Light-directed synthesis on polymeric support is a new and very promising approach to generation of combinatorial libraries, diagnostic kits, and other substrates for bioassays. In our lab we are working on the development of new efficient photo-labile protecting groups and photoreactive linkers required for these methods.
Photolithography is the main tool used in microelectronic industry and micro-engineering projects.
Production of even smaller circuits and elements require new short-wave photoresists with improved resolution, sensitivity, and thermal stability. Our investigations in this area are focused on several organic photoreactions characterized by high quantum and chemical yields, as well as exceptional photostability of the products.