The key to keeping the opposing team's running game under control is to keep the runners uncomfortable when they are on base.
Many pitchers fall into a rhythm and make it easy on the runner to get a good jump.
Or they do the same thing each time they are going home and something different when they are making a move. Left-handed pitchers for example, often look at first when they are going home and look at home when they are coming to first. When you are on the mound, do what you can to keep the runner from knowing or having a good guess what you will do on any particular pitch. Vary the time you stay set before delivering the ball. Step off the mound occasionally.