Electron microscopy is not essential. Several authors have reported an absence or decrease in the number of membrane-coating granules, or Odland bodies, within lesional keratinocytes. Although other authors have found Odland bodies to be present, most suggest that the membrane-coating granules may undergo some alterations in number or morphology. Perilesional skin uniformly shows normal keratinocyte differentiation. Unsuccessful - Oral retinoids have been successful only during continuous therapy.
Patients tend to relapse when therapy is discontinued.
Tretinoin, topical steroids, emollients, and keratolytics have shown varying, but mostly unrewarding, results. However, a large number of lesions, as well as lesion location, make this an impractical approach. Local excision may be successful, especially if the number of lesions is small. Cryotherapy is an additional possibility. Topical cytotoxic agents - Inhibit cell growth and proliferation.