Tourette, however, is not just tics. The reality is, it's much more complicated than that. Tourette people suffer with an array of difficulties from within, these difficulties are often not spoken of, or even acknowledged in many cases. This is where we have problems with people who try to deal with the visible only. The assumption is by lessening the visible tics they are improving the quality of life of the sufferer, unfortunately this is not the case, most often.
Many sufferers can develop emotional problems because of their condition.
Just as people enduring any trauma, disease or disorder can develop emotional problems. Whether these problems remain long term often depend on those around them. Acceptance and support are essentials for a stable life. Conceivably why your brother is less social now to when he was younger is because new people aren't always willing to accept differences easily. When he grew up with friends they were likely to see beyond the occasional tic, inappropriate response or 'odd' behaviour.