Role of neurotrophic factors in neuronal development. Hyperinnervation of neuromuscular junctions caused by GDNF overexpression in muscle. Click here to see Figure 2 in color. Optional background reading 1. Construction of Neural Circuits.
Neurotrophic factors enter the clinic.
Chapter 6 in Cowan, W.M., T.M. Jessell and S.L. Zipursky, Molecular and Cellular Approaches to Neural Development. Oxford University Press, New York. I. Neurotrophic factors A. Neurotrophins B. Neurotrophic Hypothesis 1. Neurons require a minimum amount of NT for survival 2. Targets synthesize and release NTs 3.