Generalized lymphadenopathy involves two or more non-contiguous nodes, larger than one centimeter in diameter, which may be tender, fluctuant, and adherent to surrounding tissue.
Patient complains of new or persistent glandular swellings on neck or in armpit or groin.
Note size, location, degree of tenderness, mobility and consistency of all palpable nodes. Perform symptom-directed laboratory examination to pinpoint or rule out infectious causes. In the presence of non-specific symptoms, order CBC, differential, liver function tests, RPR, urinalysis, CXR, PPD with controls. Obtain blood cultures if patient is febrile. Antiretroviral therapy may be helpful.