Orbivirus particles appear smooth. The mechanism responsible for segregation of the various genome segments into developing particles is not known. The majority of adults have Abs. Rotaviruses are also a major cause of mortality in calves, piglets, etc - highly infectious. Role of the Enteric Nervous System in the Fluid and Electrolyte Secretion of Rotavirus Diarrhea.
Rotaviruses are the most common cause of severe diarrhoea worldwide.
Because of the magnitude of disease associated with rotavirus infections and because public health interventions to provide clean water and improved sanitation are unlikely to decrease the incidence of disease, vaccines are being developed as the first strategy for prevention. The first rotavirus vaccine, a live oral tetravalent vaccine derived from a rotavirus isolated from a rhesus monkey was licensed in the United States in 1998. Emerging Rotavirus Vaccines . Several studies have documented that G types 1-4 are the predominant serotypes causing human disease worldwide. The diversity of strains in these countries may be important for vaccine development.