While clinical signs of disease and post mortem lesions induced by porcine circovirus are known, there is little information of the temporal pathogenesis and epidemiology of porcine circovirus. Standardized diagnostic tests have not developed and vaccines are not available. Efficient and reliable vaccines and diagnostic reagents are lacking for the H3N2 subtype. Mixed infections with two or more subtypes of influenza virus may yield reasortant viral progeny that escape the animal s existing defenses. There is a pressing need to develop multivalent vaccines and polyvalent differential diagnostic tests that identify viral subtypes associated with disease outbreaks.
Objectives Define the pathogenesis and epidemiology of porcine circovirus-induced disease.
Develop diagnostic tests and vaccines for porcine circovirus. Develop immunogens and diagnostic reagents for swine influenza.