Additionally, several acquired qualitative platelet disorders have been associated with thrombotic tendencies. Disorders associated with platelet dysfunction Myeloproliferative disorders. Acquired storage pool or release defects.
Many drugs have the potential to cause thrombocytopenia.
Others have specific actions on platelet function - some rendering them less active, others increasing their capacity to respond to stimuli. It has long been known that aspirin ingestion is associated with an increased risk of significant bleeding. ADP is known to be a potent platelet-aggregating substance. Aspirin also inhibits cyclo-oxygenase in the endothelial cells of blood vessels. This action results in inhibition of PGI2 production.