All eligible patients receive TIMT treatment. QOL assessments on regular basis.
Patients have option of open-label zoledronate at time of bone metastases.
Oxygen levels to be measured after diagnosis of prostate cancer but before any treatment in patients with clinically evident localized disease. Patient must be able to give informed consent. 3 months okay. Radiation therapy 66 Gy, standard or 4 field conformal. To evaluate benefit of addition of neoadj.