It is used in the chemical industry, present in cigarette smoke and certain foods. TGHQ, a metabolite of HQ is a potent toxicant and carcinogen in the rat kidney. Renal cancer development and progression is the result of an accumulation of genetic changes involving numerous genes.
Many genes potentially involved in renal carcinogenesis still remain unknown.
Identifying these genes will aid in delineating the mechanisms involved in chemical induced renal cancer and also provide new targets for therapeutic intervention.