They are reasonably easy to use, and are very flexible. They help with dosing antibiotics also because they compute diffusion of drug into porous spherical objects such as endocardial vegetations, and also simulate a post-antibiotic effect. They also compute the growth and kill of organisms using the Zhi-Nightingale model. They print out plots and reports of the analyses and the dosage regimen to meet the desired targets. Creatinine clearance is estimated from unstable serum creatinine values to better track the behavior of the drug in changing and unstable patients.
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