If an enteric-coated aspirin is the only preparation available, the first tablet should be chewed or crushed before administration. Directions on aspirin labels approved by the U.S. Food and Drug Administration indicate an initial dose of 160.0 to 162.5 mg to be continued daily for at least 30 days. Daily aspirin therapy should be considered for all patients at elevated risk of subsequent vascular events. For patients with transient ischemic attacks or stroke, at least 75 to 325 mg of aspirin a day is indicated. The AHA emphasizes that aspirin therapy should always be an adjunct, not an alternative, to management of other risk factors.
More data are necessary before aspirin can be considered for use in apparently healthy individuals.
In clinical trials, the majority of patients had relief of signs and symptoms within the one-week treatment period with continued improvement occurring over a period of two to seven weeks after treatment concluded. Adverse reactions were burning or irritation of the application site, itching, skin exfoliation and erythematous rash. The solution should be applied twice daily in the treatment of tinea pedis and tinea versicolor, and once daily for the indications of tinea corporis and tinea cruris. The medication should be used for one week even though symptoms may improve. The cholesterol-lowering drugs that should not be taken with mibefradil are lovastatin and simvastatin.