It is the 5alpha-dihydrotestosterone that is effective in converting the indifferent external genitalia into the male sex organs. They lack cytoplasmic testosterone binding protein and therefore cannot respond to the testosterone made in their testes. But they respond to estrogen made in their adrenal glands, so they are distinctly female in appearance. These individuals do respond to the AMH that their testes make, so they lack a uterus and oviducts. They develop as nominal, but sterile women.
Many tissues have a role in induction of the mesonephric kidney tubules.
The notochord is an early inductor. The underlying endoderm is a powerful inductor of mesonephric tubules. The neural crest is a powerful suppressor of kidney tubule formation. Its presence delays the time of determination of the mesonephric tubules. This site maintained by the Life Sciences Web Team .