The more skills that you have and the more ability you have to learn and adapt the more employable you will be. Subject matter changes so employers are looking for the ability to learn. A person who has a college degree has demonstrated the ability to learn, to meet deadlines, to work independently, to think critically, and has demonstrated intelligence. A person with a college degree will have developed oral and written communication skills. An employer is often looking for these non-specific skills rather than specific job related skills.
Most students find the big difference to be independence.
In college you will spend less time in class but you will be expected to spend more time outside class working on assignments independently. You will also have fewer opportunities to make grades in college. You have to be prepared to take examinations and demonstrate what you have learned. You have to meet deadlines such as turning in projects or assignments on time. College instructors will often be less willing to give make up examinations, or to give extra credit assignments.