The human thrombin receptor and proteinase activated receptor-2 genes are tightly linked on chromosome 5q13. In vivo gene transfer into rat arterial walls with novel adeno-associated virus vectors. Human monocyte adhesion is modulated by endothelin B receptor-coupled nitric oxide release. Permissive role of nitric oxide in endothelin-induced migration of endothelial cells. Plasmin-platelet interaction involves cleavage of functional thrombin receptor.
Nitric oxide is necessary for a switch from stationary to locomoting phenotype in epithelial cells.
Antisense oligodeoxynucleotides to inducible NO synthase rescue epithelial cells from oxidative stress injury. Genomic cloning and characterization of the human thrombin receptor gene. Structural similarity to the proteinase activated receptor-2 gene.