Home Page Edgar B, Datar S. Zygotic degradation of two maternal Cdc25 mRNAs terminates Drosophila s early cell cycle program. A fly s perspective. Uncoupling growth from the cell cycle. Wingless and Notch regulate a complex cell cycle arrest in the developing Drosophila wing.
Nutrition activates mitotic and endoreplicative cells by distinct mechanisms.
Coordination of growth and cell division in the Drosophila wing. Cell-Cycle Control In Drosophila. The development of any multicellular creature from a single egg cell involves a highly regulated program of cell proliferation. During development of Drosophila , this program unfolds in an invariant sequence, and includes a diversity of cell cycle types with distinct characteristics and modes of regulation. Much of our current work is focused on the larval wing imaginal disc, a patterned epithelium in which growth and cell proliferation are directed by spatially localized, secreted signals including wingless, dpp, and vein.