Buses are a slow but safe and inexpensive way to get around, and offer a bit of sightseeing as a bonus. Stick to areas that are well-lit and populated. Stay out of parks after dark, including Central Park . Trust your instincts. If an area makes you uncomfortable, there's probably a good reason.
Most midtown areas are pretty safe.
If you are unsure about a neighborhood, ask your concierge or hotel clerk before you venture out. New Yorkers are usually rushing to a destination, so a lost person sticks out. If you're lost in a questionable area, try not to look bewildered. Walk quickly toward the nearest area that seems better lit or more populated. Don't consult your map in the street.