This process involves the use of an orange-colored, naturally occurring dye called fluorescein. This fluorescent dye is injected into a vein in the arm or hand after which it travels to the eye in about 12 seconds. As it travels through the vascular system of the macula, the blood vessels are highlighted by the dye and any new, abnormal vessels are easily seen. While the dye passes through the macula a special camera takes multiple flash pictures to document the status of the macula. These photographs assist the ophthalmologist in finding the new vessels so that laser treatment can be administered as precisely as possible.
Most patients tolerate fluorescein angiography quite well.
However, some individuals may suffer from transient nausea and vomiting as the dye passes through their system. There have been rare reports of more severe allergic reactions to fluorescein which may be potentially life threatening. Unknown for certain. This has not been conclusively proven but, since there may be theoretical benefit from limiting sun exposure, routine wearing of sunglasses in sunny conditions is often recommended by physicians. There has been much research interest in the 'antioxidant' type of vitamin treatment of macular degeneration.