Why It Is Done In low doses, tricyclic antidepressants can be used to relieve pain. In higher doses, they may help to relieve depression. These drugs may help people manage chronic low back pain. Side Effects Side effects vary among the different drugs in this class. If a person experiences severe or intolerable side effects with one drug, another may be tried.
Most side effects decrease over time.
Lowered blood pressure. What to Think About These drugs may take up to 2 to 3 weeks to start working. They may take longer in some older adults. These drugs are usually not prescribed for people with heart problems. Questions to ask your doctor about medications.