Bigelow will ship it anywhere, in the US or to other countries, and will accept prescriptions from any licensed physician. Make sure to specify that you do NOT want LDN in a slow-release form. Reports have been received from patients that their pharmacies have been supplying a slow-release form of naltrexone. The usual adult dosage is 3mg or 4.5mg taken once daily at night. Because of the rhythms of the body's production of master hormones, LDN is best taken between 9pm and 3am.
Most patients take it at bedtime.
A number of patients who do not appear to respond to 3mg do respond when the dose is increased to 4.5mg. The therapeutic dosage range for LDN is from 1.75mg to 4.5mg every night. Dosages below this range are likely to have no effect at all, and dosages above this range are likely to block endorphins for too long a period of time and interfere with its effectiveness. Occasionally, during the first week's use of LDN, patients may complain of some difficulty sleeping. This rarely persists after the first week.