Monitor hepatic function at least monthly during therapy. May cause false-positive direct Coombs' test results. If GI irritation becomes a problem, may be administered with food. Antacids may also be taken 1 hr prior to administration. Capsules may be opened and contents mixed with applesauce or jelly for patients with difficulty swallowing.
Pharmacist can compound a syrup for patients unable to swallow solids.
Reconstitute 600-mg vial with 10 ml of sterile water for injection and swirl gently to dissolve completely. Solution is stable for 24 hr at room temperature, however manufacturer recommends administration within 4 hr to prevent precipitation. Administer solutions diluted in 500 ml over 3 hr and solutions diluted in 100 ml over 30 min. Emphasize the importance of continuing therapy even after symptoms have subsided. Length of course of therapy for tuberculosis depends on regimen being used and underlying disease states.