When the heart works harder, it beats faster. It may work so hard that it temporarily loses its natural rhythm. This is called fibrillation, and it can be very dangerous because it stops the flow of blood through the body. Miscommunication in the Brain Cocaine and amphetamines change the way the brain works by changing the way nerve cells communicate. Nerve cells, called neurons, send messages to each other by releasing special chemicals called neurotransmitters.
Neurotransmitters are able to work by attaching to key sites on neurons called receptors.
One of the neurotransmitters affected by cocaine is called dopamine. Normally, once dopamine has attached to a nerve cell's receptor and caused a change in the cell, it's pumped back to the neuron that released it. But cocaine blocks the pump, called the dopamine transporter. Dopamine then builds up in the gap synapse between neurons. That's why someone who uses cocaine feels an extra sense of pleasure for a short time.