Most travelers fly into Quito.
All flights to the Galapagos originate in Quito or Guayaquil. From the United States and Canada Flights from the US are always routed through Miami, Houston, and New York, with thousands of connecting flights from other cities. There are no direct flights from Canada. You must have a connecting flight to one of the three American cities listed above. From Europe Flights to Ecuador leave from London, Madrid, Amsterdam, and Frankfurt and all include at least one stopover.