Changing of layer settings is very much reduced. Specific views along with their layer settings which can be saved in a template file might for example be site plan, demolition plan etc. A lot of work can then be done from paper space by activating the viewports to floating model space mode. Instead of having viewports on a separate layer and turning that layer off when you go to print, you may wish to have the viewports on the defpoints layer with has the effect of rendering them invisible to the printer. As in model space, named views can be saved so they can be quickly viewed.
Problem is that model space can insert properly but paper space is lost.
To dimension in model space and have the dimension appearing correctly in paper space separate dimension styles are created. Layers would also need to be provided that relate to differently dimensioned parts of the structure so that the y can be selected. Text that relates to the drawing sheet only. All other text. Separate by layers as appropriate and keep these in model space.