Anecdotal reports have suggested that supplementation with biotin will increase the effectiveness of fatty acids. Many veterinary dermatologists recommend that fatty acids be used for 9-12 weeks before concluding they are not helping the condition. Since fatty acids need to be incorporated into cell membranes, they usually do not have an immediate effect. Often a pet must be on a fatty acid supplement for a month before any positive results can be seen. Many veterinary dermatologists recommend that fatty acids be used for 9-12 weeks before considering discontinuation because of lack of positive results.
Most experts advise treating with fatty acid supplements twice daily.
Some research has shown that 2-10 times the recommended dose may be necessary to control pruritus in dogs. Risks and side-effects of fatty acid supplementation There are few side effects of fatty acid supplementation. The most serious, but rare complication, is pancreatitis. This is an inflammation of the pancreas that can cause pain, diarrhea, vomiting and dehydration. Since fatty acids are polyunsaturated fats, they do add calories .