Doses of 50 or 100 mg were used according to the size of the child. The result was that sumatriptan was not more effective than the placebo tablet according to the primary endpoint of the trial. My limited clinical experience with childhood migraine is in agreement with this recommendation. My experience indicates that amitriptyline is the most reliably effective migraine preventive in children. A recent evaluation of this drug for childhood headaches at the headache center at the University of Cincinnati by Hershey et al. found that it was an effective preventive for children with frequent migraine attacks.
Most children tolerate amitriptyline well.
Amitriptyline is the premier preventive drug for chronic tension-type headache in children as it is in adults . This drug was also shown by Hershey et al.