Primary malignant neoplasm or a metastatic focus are less likely. Diagnosis Eosinophilic granuloma Discussion Radiology Eosinophilic granuloma occurs most frequently in children and is rare beyond the age of 20. Solitary painful bone lesions are the most ommon presentation, although they may be disseminated and polyostotic. Eosinophilic granuloma is one of the diseases that may have an associated sequestrum. The skull is usually involved, but lesions may be seen in any bone.
Prognosis is excellent.
Microscopically, it is composed of large multinucleated giant cells with a polymorphous, eosinophil-rich inflammatory infiltrate. The differential diagnosis includes osteomyelitis, non-Hodgkin's lymphoma, and Hodgkin's disease. Special studies, including electron microscopy, may be necessary to resolve this differential. Edeiken J, Dalinka M, Karasick D. Roentgen diagnosis of diseases of bone. The histiocytoses of childhood.