To its credit, as pitchers fatigue they lose their control and balls rarely land where you expect them. Unfortunately pitchers don't seem to lose velocity as their pitch counts increase. Another negative is that AI players swing at anything. After a few games I realized I could follow a pattern with every batter. On the first pitch I'd pitch high and outside.
Next ball is high and inside.
Otherwise, I'd just paint a different corner and hope for a third strike. I routinely netted a dozen or more strikeouts a game. On the basepaths, the AI runners are a bit confused. I have yet to see an AI runner steal, and usually they make no attempt at extra bases or else they turn around if a throw is made. For both the AI runners and your players, they jog along the basepaths.