2 Severe hemorrhagic gastroenteritis developed 48 hours after exposure in one case. The diagnosis of ibuprofen toxicity in dogs or cats is usually based upon exposure history and the development of associated clinical signs. Ibuprofen blood levels are not widely available, although qualitative analysis could be performed on serum, urine, or hepatic tissues using gas chromatography and mass spectrophotometry. 2,18 Other toxicological rule outs for renal failure include ethylene glycol, lily toxicosis in the cat, calcipotriene, cholecalciferol, and zinc toxicity. The primary goal of treatment is to prevent or treat gastric ulceration, renal failure, CNS effects, and possibly hepatic effects.
Prognosis is good if animal is treated promptly and appropriately.
Delay in treatment can decrease survival potential with large exposures. Stabilization Assisted ventilation and supplemental oxygen may be required if the animal is comatose. Acid base imbalances should be corrected. Metabolic acidosis is treated with slow IV infusion of sodium bicarbonate in fluids. Bicarbonate and fluid therapy must be monitored closely via blood gases and adjusted if pulmonary edema or metabolic alkalosis develops.