This group is interested in the role of growth factors in the development of mammalian neurons. The retrograde transport of signalling molecules plays a vital part in the function of the neurotrophic control of synaptogenisis and neuronal survival. We are studying the control of retrograde axonal transport by the various second messenger cascades present during neuronal development. This mouse shows a hypertolerance to morphine analgesia and the group is investigating the mechanism of the production of opioid tolerance, dependence and addiction using this genetic approach. Synaptic Biochemistry Molecular mechanisms underlying neurotransmitter release.
Research is focused on synaptic vesicle exo- and endocytosis, and calcium channel function.
We study the brains of rats in order to understand how synapses work and how synaptic signals are added together to generate the flow of information in the central nervous system. To do this, we apply patch clamp and imaging techniques to brain slices and cell cultures taken from the hippocampus and cerebral cortex. The ultimate goal of our work is to assemble data about individual neurons into large-scale models of how the brain might operate. In order to understand the highly complex functions of the brain, we must understand how individual neurons communicate with each other. This communication occurs at specializedsynaptic contacts, and the overall aim of The Synaptic Structure and Function Group is to understand how synaptic strength is egulated, and how synaptic signals are processed by target neurons.