For a receptor to bind to a substrate, that substrate must have the appropriate shape, size, and noncovalent interactions with the receptor. These noncovalent interactions include ionic bonds, hydrogen bonds, polar attractions, and van der Waals attractions. The structure of receptors vary, so their binding requirements will vary as well. Histamine meets the binding requirements for both the H 1 and H 2 receptors, whereas the structure of cimetidine is such that it can bind only with the H 2 receptor. An organometallic compound is a compound containing a carbon-metal bond.
Organometallic compounds are nucleophilic.
The carbon portion of the organometallic compounds we have studied this quarter are nucleophilic. There are other organometallic compounds of the transition metals that are electrophilic. Very briefly explain your answer to the previous question. The carbon-metal bond of an organometallic compound is polar, because carbon and metals do not have the same electronegativity. Carbon, being more electronegative than any metal, bears a d - charge.