Liver function tests should occur with Actos and Avandia. Do not use if ALT exceeds 2.5 X upper limit of normal or if active liver disease is present. If ALT exceeds 3 X upper limit of normal during treatment, recheck as soon as possible. Slight increase in vascular volume occurs. Some premenopausal anovulatory patients have a return of ovulation.
Pregnancy can occur.
Oral contraceptives may be less effective when administered with thiazolidinediones. Actos partially metabolized by cytochrome P450 isaform CYP3A4. Avandia predominantly metabolized by cytochrome P450-CYP2C8 and somewhat by 2C9. Use caution in severe to moderate heart disease. Dosing - Actos Approved for monotherapy or in combination with sulfonylurea, metformin or insulin Initial starting dose in monotherapy or combination therapy is 15mg or 30mg once daily, taken without regard to meal.