He held a fellowship and post at the MRC Cell Biophysics Unit at King's College in London and spent a sabbatical year at CNRS, Gif sur Yvette in France. We are interested in the biology and pharmacology of nitric oxide.
Nitric oxide is a mediator implicated in inter-cell communication and killing invading organisms.
In the cardiovascular system, it has an important role in preserving the integrity of the vascular system and preventing atherosclerosis and thrombosis. Nitric oxide has a darker side as its overproduction along with other reactive oxygen can lead to cell damage. We currently use biochemical, immunological and organ bath methods to understand the biology of nitric oxide in the cardiovascular system in health and disease. Our studies are focussed on the study of the pathways that regulate the balance between nitric oxide production and other reactive oxygen and nitrogen species, such as superoxide anions and peroxynitrite that may result in detrimental effects to cells. These studies include projects on the influence of polyunsaturated fatty acids on nitric oxide-dependent pathways and the effect of antioxidants on gene expression.