Use of a pharmacokinetic model incorporating discontinuous gastrointestinal absorption to examine the occurrence of double peaks in oral concentration-time profiles. Pharmaceutical Research, Vol. 9, No. 3, 350-356, 1992. Applications and simulations of a discontinuous oral absorption pharmacokinetic model. Pharmaceutical Research, Vol. Hope this helps.
Rats exhibit enterohepatic recirculation of many chemicals.
I am interested in any ideas about determining absorption rates independently. They are often crucial components in PBPK models of orally dosed compounds. The observed peaks are reflection of the fermentative digestion of feed in the large intestine and the release of the bound drug. Dra Maria Fabiana Landoni, PhD Catedra de Farmacologia. With the decaying cos function, the blood concentration can have several decreasing peaks.