While interacting with a young pup you must decide what behaviors you want in the animal as an adult. Most people do not want their full grown wolf or wolf hybrid mouthing or biting. Do not allow the pup to mouth. Wolf parents are very tolerant while pups are small. They DO NOT punish a pup for chewing and biting.
Many hybrid owners make the mistake of trying to physically dominate their animals.
This can damage the relationship you are trying to build with the animal. It is also very valuable to teach the pups to submit on cue. This is not to say that as an adult they will submit on cue every time, but you will have laid the foundation for the behavior. You must be very consistent and condition the animal to submit without thinking each time. This works well if done properly.