Antibodies to the ganglioside GQ1b is associated with Miller Fisher syndrome. GQ1b is found at paranodal segments and in highest concentrations in the oculomotor, trochlear, and abducens nerves. Treatment Treatment is with either plasmapheresis or intravenous immunoglobulin. No double-blind, controlled trials have been reported. Prognosis Prognosis is good with recovery after a mean of 10 weeks.
Most patients show a complete remission without any residual symptoms.
Several cases of relapsing disease have been reported. The use of intravenous immunoglobulin in Miller Fisher syndrome. Bradley, Walter G., Daroff, Robert B., Fenichel, Gerald M., Marsden, C. David. Neurology in Clinical Practice. Second edition, 1996.