Libido Males with decreased libido may have low testosterone levels secondary to hyperprolactinemia. Hyperprolactinemia may act to suppress pulsatile GnRH release. Hyperprolactinemia should be considered as a potential cause of hypoandrogenism and subsequent decreased libido. Prolactin-Inhibitory Factor Dopamine is the predominant physiologic prolactin inhibitory factor. The axon's response will further release dopamine into the median eminence originate in the perykaryons in the arcuate ventral medial nucleus of the hypothalamus.
Prolactin metabolism is delayed in renal failure, and there is also increased production.
Correction of renal failure with transplantation causes a return of prolactin levels to normal. Hyperprolactinemia may play a role in the hypogonadism found in many patients with chronic renal failure. One-third of women with hyperprolactinemia have pituitary adenomas. Two-thirds of women with galactorrhea and amenorrhea have hyperprolactinemia. Chadwick's Sign Increased vascularity results in a characteristic violet color of the vagina during pregnancy.