Typically, the method consists of two parts. By quantitative comparison of the two series, a map of brain perfusion can be computed. However, most studies to date have taken single images during extreme mania or depression. This radiation-free technique allows multiple and serial imaging of the same subject. Although data are still being analyzed, initial work suggests that global gray matter perfusion correlated with varying mood states, although the relationship is complex.
Regional analysis is in progress.
Although the relationship between perfusion and the mood cycle is complex, this new imaging tool will likely aid in understanding the longitudinal course of BPAD and other neuropsychiatric disorders, generating movies of disease progression and recovery. The following graphic consists of Patient DAB's and Control PAR's mood function charts. Points above the line represent increased mania. Points below the line represent increased depression. Vertical lines represent days on which subjects were scanned.