Constipation, dry mouth, rhinitis, weight gain, and hepatic enzyme elevations are less frequently reported. Large doses of olanzapine such as those seen after overdose consistently cause a depressed mental status. There is no specific antidote available for the treatment of olanzapine overdose. Aggressive supportive measures should include airway management, intravenous fluids, and pressors for the treatment of hypotension. Monitoring parameters include serial ECGs and vital sign assessment.
Most patients respond and do well with supportive care alone.
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