Dr. Phil Andrews. This course will relate protein structure to various aspects of protein function. The course will begin with a general introduction to three-dimensional protein structure including discussion of structure determination methods and forces in protein structure and stability. The emphasis will be to relate details of structure to the function of the proteins discussed. The course will include a molecular graphics component aimed at hands-on experience for the students.
Physical chemistry is recommended.
A review of hormone and neurotransmitter receptors as well as the cellular effectors that are regulated by receptor activation. Oncogene products as signal transducers and the interaction of the known signalling pathways are also covered. The various techniques used to study signal tranduction as well as important experimental strategies employing these techniques will also be presented. 570, or equivalent or permission of instructor. Dr. Kun-Liang Guan.