Clinical signs are variable. Other syndromes that have been reported include polymyositis, myocarditis, peripheral lymphadenopathy and splenomegaly. Dermatologic signs include seborrheic skin disease, panniculitis, nasal dermatitis, cutaneous and mucocutaneous vesicobullous disease, footpad ulcers and hyperkeratosis, vasculitis with ulceration and necrosis. CBC and Chemistry profile should also be done. Gold is not indicated in cases of lupus due to renal complications.
Prognosis is guarded.
Collies, Shelties and Dobermans may be predisposed. In this disease antibodies are produced against components of the basement membrane causing the formation of bulla and then deep ulcers. Clinical signs of BP are very similar to pemphigus vulgaris. Other areas of the body that may be affected include the groin and axillae. Animals may be febrile and anorectic.