This allows researchers to give patients a higher dose of the drug for a longer term, noted Steinbach. After six months, the 30 patients taking 400 milligrams of the drug experienced a 28 percent reduction in the number of polyps compared with a 4.5 percent reduction in the 15 people in the placebo group. The 32 patients taking 100 milligrams experienced an 11.9 percent reduction. Side effects of the drug were diarrhea and abdominal discomfort, but the incidence of these side effects didn't vary greatly between the placebo and control group. However, low doses of aspirin can have benefits that celecoxib does not, such as reducing the risk of heart attack and stroke, he noted.
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