This is a new mode of communication between the immune, neural and endocrine systems. These immunocytes, serving as mobile single cell glands, are likely to be a phylogenetically ancient system that rapidly delivers otherwise unavailable biologically active materials to specific brain regions upon demand. Currently, we are working on understanding the function of brain mast cells in avian and mammalian species. Localization of a suprachiasmatic nucleus subregion regulating locomotor rhythmicity. A diffusible coupling signal from the transplanted suprachiasmatic nucleus controlling circadian locomotor rhythms.
Mast cells migrate from blood to brain.
Gonadal steroids regulate the number and activational state of mast cells in the medial habenula.