The CNS is avascular early in embryonic development yet it has an intricate vascular tree in adults. This talk will detail the role of vasculogenesis and angiogenesis in the formation of CNS vessels. The CNS is also characterised by overproduction of vessels requiring significant vascular pruning. Our latest studies provide evidence that apoptosis plays a significant role in the removal of excess endothelial cells, but more importantly, we have provided evidence of a previously unexpected mechanism of endothelial cell migration and redeployment during remodelling of the developing CNS vasculature. Map Visitors and Students are most welcome to any of our seminars.
Free parking is available.
The University of New South Wales, Gate 11, Botany St, Randwick. Please note that last minute changes occur from time to time. Abstract Pelvic ganglia are unusual as they are a mixture of sympathetic and parasympathetic neurons. They also show a remarkable degree of plasticity after different types of injury, with very rapid axogenesis, specific targeting of new sprouts to particular groups of neurons, and changes in neurotrophin signalling. This raises issues such as how these changes impact on restoring autonomic circuits after injury, and what mechanisms may be available to manipulate these changes.