Nuts and chocolate also contain significant amounts of this amino acid. Normally, the body makes enough arginine, even when it is lacking in the diet. Most people do not need to take extra arginine. While some people with serious infections , burns , or other trauma should take arginine, appropriate amounts must be determined by a doctor. Most research on cardiovascular disease has used between 6 and 20 mg per day.
Optimal intakes remain unknown and are likely to vary depending upon the individual.
Arginine has so far appeared to be free of obvious side effects, although some doctors are concerned that increases in growth hormone triggered by arginine could overwork the pancreas. Individuals with kidney or liver disease should consult their doctor before supplementing with arginine. Large amounts of arginine in animals can both promote 13 and interfere with cancer growth. On the other hand, in people with cancer, arginine has been found to stimulate the immune system . At this time it remains unclear whether arginine is dangerous or helpful for people with cancer .