We have recently completed a longitudinal survey of the non-fasting plasma glucose levels in a small group of current generation mutant mice and discuss these findings, along with methodological problems associated with plasma glucose determinations in mice. The molecular basis for the mutation remains unknown.
Mutant females are sexually dysfunctional.
This is associated with hyperinsulinemia already detectable in the preweaning phase. After weaning at 3-4 weeks, hyperphagia and an increasingly severe insulin resistance develop. Remission from hyperglycemia is correlated with a compensatory hyperplasia and hypertrophy of the pancreatic beta cells. Study Description Groups of 5 mice of each of the various genotypes described below were received from the Animal Resources Unit at approximately 4 weeks of age and segregated by sex, with each double-pen plastic cage containing a total of 5 mice. Mice were weighed and plasma glucose determined at biweekly intervals.