And Metabolic Disease Sponsors do not influence content. One of the first chromosomal linkages identified in humans is between the NPS locus and the ABO blood group on chromosome 9. It has an incidence of 1 in 50,000 live births. Age of onset and degree of severity cannot be predicted.
Patients are at risk for nephropathy resembling glomerulonephritis.
Proteinuria is the first clinical symptom and some cases will progress to end-stage renal disease, which requires transplantation. Although many patients are asymptomatic until the early adult years, proteinuria may occur before the age of 2 years. NPS is a panethnic disorder. Males and females are equally affected. This is the first sign of renal involvement.