However, it is unclear to what extent such functions specifically suppress breast and ovarian cancer. Here we analyse what is known of BRCA gene function and highlight some unanswered questions in the field. AB - Ovarian cancer is the first leading cause of death from gynecologic cancer.
Gene therapy is a new alternative therapeutic approach.
16 gene therapy clinical trails are applied to ovarian cancer. A knowledge of basis concepts of gene transfer strategies, is needed to understand these different treatment strategies. Thus, the goals of this review are, first, to provide the basis concepts of gene transfer strategies to the obstetrician-gynecologist and second, to submit recent gene therapy clinical trials about ovarian cancer. Ten patients at risk for BRCA1 mutations were studied. The results of BRCA1 mutation analysis and IH were compared.