If you've suffered mental illness, substance abuse, or depression in the past, make sure the doctor is aware of this before therapy begins. Roughly half the people taking Sustiva develop symptoms such as dizziness, lack of concentration, or drowsiness. Avoid driving or operating machinery while these symptoms occur. They are likely to improve with continued therapy, generally within 2 to 4 weeks. One of the most common side effects of Sustiva is skin rash.
Most rashes usually clear up on their own.
However, for roughly one patient in 100, the drug causes a severe rash associated with blistering, skin peeling, and fever. If you develop this type of rash, call your doctor. You may have to stop taking Sustiva. In a few patients, Sustiva has toxic effects on the liver. If you've had hepatitis or must take other medications that could damage the liver, your doctor will probably check your liver function regularly.