According to the medical literature, there may be other FMF gene mutations that have not yet been identified. It has also been suggested that certain FMF gene mutations may be inherited as an autosomal dominant trait, meaning that only a single copy of the disease gene is needed to result in expression of the disorder. According to researchers, such theories may be supported by reports in the medical literature in which individuals with just one copy of a known FMF gene mutation have developed the characteristic features associated with the disorder. The symptoms generally begin during childhood or teen years. Episodes of symptoms typically continue throughout life.
Most affected individuals have ancestors who lived in areas around the Mediterranean Sea.
Shephardic and Iraqui Jews, Turks, Levantine Arabs, and Armenians are at a higher risk for this disease than other populations. Approximately 50 percent of the people with Familial Mediterranean Fever have no known family history of this disease. After a few hours, the pain becomes more localized to the lower right portion of the abdomen. The following disorders may be associated with FMF as secondary characteristics. The excessive accumulation of amyloid caused the affected organ to malfunction.