Given the history and personalities involved, if the guarantees those amendments represent hadn't been intended to be absolute and perpetual, the Founders wouldn't have bothered making them. Even so, rights aren't a gift of the Founders, they've existed since the dawn of human history. Repeal the Second Amendment and my fundamental and inherent right to the means of self-defense would not be altered or diminished. Guns save vastly more lives than they take. A few thousand each year suffer wrongful death where a gun is the instrument.
Millions use guns to defend themselves, usually without having to fire a shot.
As a friend of mine puts it, Handgun Control is an organization that would rather have a woman raped in an alley and strangled with her own pantyhose, than see her with a gun in her hand. The dead and wounded at Columbine were not victims of too many guns, but too few. No one there had the machinery and the moxie to defend them. Only this time it will be your fault. You are the very sort the Founders meant to protect us from.