The snakes Alsophis portorcensis feed almost exclusively on lizards. Also, birds such as the falcon and hawk are potential predators. The major causes of the depletion of the Culebra Island Giant Anole are the destruction of their living environment and pollution of their habitat. Since Culebra Island is now becoming a tourist attraction, people are bulldozing the forests. The home where the original Anolis Roosevelti was found has now turned into condos and hotels.
Pollution is also a big factor in the extinction of the species.
With all of the pesticides that are sprayed on the fields in Puerto Rico, the forests are also sprayed by mistake. This creates plants and fruits that have chemical imbalances. The Culebra anole eats the fruit or plant and is killed. With all of this destruction and pollution going on in Puerto Rico, the anole has a hard time living peacefully. The recovery effort for the anole should proceed with additional efforts to confirm the existence of this species.