Change in ErbB-2 expression is linked to one in five cases of breast cancer. We apply genetic screens to determine which adaptor molecules and second messengers are required downstream of each phosphotyrosine in the signalling domain of ErbB-2. Axon repulsion from the midline of the Drosophila CNS requires slit function. Genetic analysis of vein function in the Drosophila embryonic nervous system. DmUNC119 can function in place of C. elegans unc-119.
Repellent signalling from slit requires the Leucine Rich Region.