Minor adverse events reported after vaccination of children are similar to those in adults but are less frequent. The viral proteins are adsorbed on aluminum hydroxide and aluminum phosphate. The vaccine also contains 2-phenoxyethanol preservative and traces of formaldehyde and neomycin sulfate. The recommended adult dose is 1.0 mL, injected intra-muscularly, preferably in the deltoid region. The need for and timing of booster doses have not been established.
Local changes occur at the same frequency after each dose in the series.
Infrequent adverse effects also include malaise, nausea, and vomiting. Side-effects of the combined vaccines do not differ in frequency or severity from the monovalent vaccines. The combined vaccine is recommended for pre-exposure prophylaxis of HAV and HBV infections in adults at risk, such as those residing in or travelling to areas where both infections are highly endemic. Details regarding vaccine use can be obtained from the product monograph. The product is supplied as monodose vials.