Caution U.S. Federal law restricts this drug to use by or on the order of a licensed veterinarian.
Milbemycin oxime is classified as a macrocyclic anthelmintic.
Lufenuron's mode of action is interference with chitin synthesis, polymerization and deposition. Lufenuron has no effect on the adult flea. After biting a lufenuron-treated dog, the female flea ingests a blood meal containing lufenuron which is subsequently deposited in her eggs. Lufenuron prevents most flea eggs from hatching or maturing into adults and thus prevents and controls flea populations by breaking the life cycle. Lufenuron controls flea populations by preventing the development of flea eggs and does not kill adult fleas.