Patients with systemic lymphomas of the same histological variety survive longer. Median survival time for AIDS patients treatment is 1.5-3 months. Median survival for favorable solitary lesions documented up to 45 months. With primary chemotherapy the rates are lower but the follow up is shorter. There is no difference in the histology or immunohistology between primary CNS and systemic lymphoma.
Presentation depends upon location of lesion.
Prognosis is poor with most patients dead within 5 months. Second most common malignancy in AIDS after Kaposi's sarcoma. The CT appearance differs with lesions being large and ring enhancing. Treatment remains palliative although it must be individualized for those with excellent performance status. Prognosis is very poor with median survival of 1.5-3 months.