Hereditary nephritis is a dominant, x-linked disease that affects young dogs more severely than bitches. After the first three months of life, the dogs begin to lose weight dramatically. Males die of renal failure usually by 15 months of age. Females, who carry the disease, also lose weight and develop proteinuria between two and three months of age, but the disease progresses much slower than in the males.
Females have the likelihood of succumbing to renal failure later in life.
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