Neurological changes in chronic Chagas' disease include changes at the level of the central, peripheral or autonomic nervous system. Its presence is the best definition of the acute phase as all other signs are variable. In vitro infected fibroblast showing a large number of intracellular amastigotes. T.cruzi trypomastigotes reacting with monoclonal Ab. Both drugs produce anorexia, weight loss, headache and dizziness, gastric irritation, and sometimes peripheral neuritis.
Experimental drugs are under evaluation.
Treatment of patients in the intermediate or chronic phase is controversial. Congenital Chagas'disease and transfusion-associated acute disease require Rochagan therapy. Vector control programmes involving insecticide spraying with modern pyretroids and new tools for delivery in endemic areas is being carried out in some Latin American countries. TEM microphotograph of T.cruzi epimastigote.