I was scratching my ear, wondering, mystified, whether Harris' entire medical file had actually been released to selective, media-minded psychiatric opinion leaders to mull over. They did, however, appear to know volumes about how Luvox and the other, newer antidepressants work in the brain. Harris and co-gunman Dylan Klebold had apparently planned the attack far in advance. No to all of the above, because no one knows for sure. The data required to answer these critical questions are simply not available.
Research is rudimentary, at best, particularly the long-term variety.
Luvox and its cousins are known, for example, to induce mania in some patients, and mania can spur bizarre behavior. This is a widely recognized feature of antidepressants, as documented by their very own manufacturers. These drugs are also associated with bouts of irritability, aggression and hostility. Exactly how all this behavioral change is processed in the brain and how long-lasting it might be is poorly understood. Contrary to the big shows of knowledge by psychiatrists, there is a whole lot of guessing going on.