Nefazodone is an antidepressant used to treat mental depression.
Nefazodone hydrochloride is a synthetically derived phenylpiperazine antidepressant.
The mechanism of action of nefazodone, as with other antidepressants, is unknown. Preclinical studies have shown that nefazodone inhibits neuronal uptake of serotonin and norepinephrine. Peak plasma concentrations occur at about one hour. Therefore, the physician who elects to use nefazodone for extended periods should periodically reevaluate the long-term usefulness of the drug for the individual patient. Contraindications Coadministration with terfenadine or astemizole with nefazodone HCl is contraindicated.