The risk of increased uterine cancer has been raised but this appears to be of low order and more common in lab animals. Rare occurrences of thrombocytopenia are noted. This would be a reasonable choice, especially with the family history of breast cancer. This would likely cure the disease but would leave the patient with a cosmetic problem with significant difference of breast size. In a large breasted woman this would be a better option.
Radiation therapy is effective in preventing recurrence of disease.
My concern is change in skin pigmentation and overall breast consistency. The right breast is involved therefore RT would not be a factor in possible effect on the heart. I have not been pleased with the cosmetic effects of RT to the breast. Simple mastectomy would resolve the problem regarding the right breast. It would not be cosmetically acceptable to the patient from what she has told me.