Some types are capable of establishing persistent asymptomatic infections in tonsils, adenoids, and intestines of infected hosts, and shedding can occur for months or years. Epidemics of febrile disease with conjunctivitis are associated with waterbourne transmission of some adenovirus types, often centering around inadequately chlorinated swimming pools and small lakes. ARD is most often associated with adenovirus types 4 and 7 in the United States. 40 and 41 cause gastroenteritis, usually in children. Since adenovirus can be excreted for prolonged periods, the presence of virus does not necessarily mean it is associated with disease.
Most infections are mild and require no therapy or only symptomatic treatment.
Because there is no virus-specific therapy, serious adenovirus illness can be managed only by treating symptoms and complications of the infection. Maintaining adequate levels of chlorination is necessary for preventing swimming pool-associated outbreaks of adenovirus conjunctivitis.