The answer is yes. I recommend that about 20 mg of natural progesterone can be safely used as a progesterone replacement. This amount of course is per application. Yes, Premarin, a synthetic estrogen can create a biochemical situation know as estrogen dominance which makes a woman retain fluid, fat, and salt in the tissues. This will occur if there is a lack of progesterone which has a diuretic and balancing effect on the system.
Progesterone also acts as a natural anti-depressant and sedative to the nerves.
This is most common, especially when Premarin alone is used or is balanced with a synthetic progesterone which does not possess the natural diuretic or anti-depression effects of the natural substance. Many herbs like Dong Quai, Black Cohosh, and even Ginseng are phytoestrogens and are adding to the estrogen dominance condition that Premarin has set the stage for. This is why a natural progesterone source or progesterone-based herbs like Wild Yam, Chaste Berry, and Yarrow are my favorites. The progesterone in Progest cream as well as Progestacare is identical to the progesterone that your body should be producing on its own. Therefore there are minimal side effects.