Vincristine is occasionally given to treat resistant cases, but it has no proven benefit. Supportive care for end-organ damage may be required. Hemodialysis is required occasionally for renal failure. Anticonvulsants such as phenytoin may be required to control seizures. Platelet-depleted packed RBCs may be necessary for severe hemolytic anemia.
Platelet transfusion is contraindicated since it is associated with rapid deterioration.
The platelet aggregation worsens with platelet transfusions. In some studies, extensive platelet aggregates were found throughout the CNS on postmortem examination. The differential diagnosis is extensive for thrombocytopenia, but early recognition of TTP is essential for the patient's survival. The goal of therapy is to reduce destruction of platelets. Glucocorticoids - These agents have immunosuppressant activity.