Acute and subacute brucellosis are non-specific. Irregular fever, headache, profound weakness and fatigue, chills, sweating, arthralgias, mylagias. Depression and mental status changes.
Fatalities are uncommon.
Blood cultures require a prolonged period of incubation in the acute phase. Bone marrow cultures produce a higher yield. Confirmation requires phage-typing, oxidative metabolism, or genotyping procedures. Therapy with rifampin, a tetracycline, and an aminoglycoside is indicated for infections with complications such as endocarditis or meningoencephalitis. No approved human vaccine is available.