These markers also allow one to accurately assess the biology of a specific tumor in a specific patient. Experimental approaches involve analysis of oncogenes, tumor suppressor genes, genetic instability, and tumor clonality. Investigative techniques include the use of standard histological examination to molecular biologic analysis of patient outcomes. Usefulness of colonoscopy with biopsy in the evaluation of patients with chronic diarrhea. Noffsinger A, Kretschmer S, Belli J, Fogt F, Fenoglio-Preiser C .
Microsatellite instability is uncommon in the intestinal mucosa of patients with Crohn s disease.
Grogan T, Fenoglio-Preiser C , Zeheb R, Bellamy W, Frutiger Y, Vela E, Stemmerman G, MacDonald J, Richter L, Gallegos A, Powis G. Thioredoxin, a putative oncogene product is overexpressed, in gastric carcinoma and associated with increased proliferation and increased survival. Microsatellite instability and ras mutations in ulcerative colitis.