This is not unusual for proteins like somatrem growth hormone. If the solution is cloudy or contains particulate matter immediately after reconstitution or refrigeration, the contents must not be injected. It is recommended that somatrem be administered using sterile, disposable syringes and needles. Before and after injections, the septum of the vial should be wiped with an antiseptic solution to prevent contamination of the contents after repeated needle insertions. The syringe should be of small enough volume that the prescribed dose can be drawn from the vial with reasonable accuracy.
Expiration date is stated on the label.
Reconstituted vials should be used within 14 days after reconstitution. After reconstitution, vials must not be frozen. Also contains mannitol 40 mg and 80 mg, sodium phosphates 1.7 mg and 3.4 mg respectively. Phosphoric acid may be used for pH adjustment. Biological potency is determined by measuring the increase in body weight induced in hypophysectomized rats.