The resulting monoclonal antibody was determined to be IgG1-Kappa using a Zymed kit for typing. The antibody binding site is located at the C-terminal 68 amino acids of protein B23. A recent library search on B23 and nucleophosmin publications yielded 148 references. Recently, they have shown that NPM-translocation is a part of the apoptosis pathway that involves damage to the nucleolus. Papers describing the invention include Exp.
References are available upon request.
Both antibodies and hybridoma cells are available.