While these validation results were encouraging, they were still very qualitative in nature, and contained unexplained anomalies such as secondary areas of positive potential in the atrial region or in parts of the ventricle where there was no angiographic evidence to indicate ischemia. The geometry used in this study was realistic but not anatomically accurate nor did it contain inhomogeneous regions. A recent report by Tilg et al. described a validation approach in humans that offers exceptional potential for testing at least one form of the inverse solution. They then performed MR imaging and a magnetocardiographic mapping, all within a day of the endocardial mapping. Using the geometry and the body surface potentials, they then created customized inverse solutions in terms of activation time, which they could validate against the direct measurements.
Preliminary results suggest a reasonably good match between predicted and measured values.
It is also possible to formulate an inverse solution in terms of reconstructing endocardial potentials from potentials measured in the interior of the cavities in the heart. Such an approach has been developed by Khoury et al.