The report should indicate whether the cells are thought to be of endocervical or endometrial origin, when possible. A report of adenocarcinoma indicates a probable invasive tumor. The report should specify whether an endometrial, endocervical, or extrauterine site is suspected. Other malignant neoplasms may be suspected on the basis of certain cytologic findings. These include small cell carcinoma, melanoma, lymphoma, and sarcoma.
Invasive cancer is very rare.
The validity of this subclassification in predicting CIN by biopsy was subsequently confirmed. Undetermined Significance A report of atypical glandular cells of undetermined significance should indicate, when possible, whether an endometrial or endocervical origin is favored. Atypical endometrial cells should be evaluated by endometrial biopsy. Atypical endocervical cells are further subclassified as favoring either a reactive or a neoplastic process. Any woman with a cytologic specimen suggesting the presence of a high-grade lesion should undergo colposcopy and directed biopsy.