GI distress 2. In normal people, inhibition of anticholinesterases causes muscle weakness. NMJ depolarizes and connot repolarize due to continues presence of ACh. Called depolarizing blockade.
Muscles are no longer under voluntary control giving weakness.
Nondepolarizing blockade of the neuromuscular junction by curare is competitive. Use a cholinesterase inhibitor to increase the amount of ACh at the synapse. The heart is innervated by both sympathetic and parasympathetic nervous systems. Increase HR by reducing vagal tone. Several hours later she has trouble swallowing, progressive weakness of the arms and legs, constipation, urinary retention and reduced salivation and lacrimation.