Despite extensive study, no adverse effects to the human body have been demonstrated i,ii,iii . Subcommittee on Health Effects of Ingested Fluoride. Health effects of ingested fluoride. The use of fluoride supplementation in caries prevention would seem to be effective but compliance can be problematic. The place of fluoride supplements in caries prevention today.
Plaque control using fluoride toothpaste is effective in the prevention of tooth decay.
There are long term clinically significant reductions in dental caries showing a dose - response relationship i,ii,iii,iv . Fluoride toothpastes, rinses and tablets. Stookey GK, DePada PF, Featherstone JDB et al. A Critical review of the relative anticaries efficacy of sodium fluoride and sodium monofluorophosphate dentifrices. Top 1d .