No unique microorganisms have been identified. Rather, the condition seems to involve an anaerobic periodontal flora similar to that which causes conventional periodontal disease. The role, if any, played by host factors is equally poorly defined. Management of NUP requires care by a dental professional familiar with this condition. Where bone is exposed, sequestration may occur, sometimes without tooth loss.
Home care is very important.
Affected areas need to be irrigated locally with povidone iodine and the mouth rinsed with chlorhexidine. Antibiotics effective against gram-negative flora may be needed in cases of severe disease, but these must be used in conjunction with the local measures described above. Tuberculosis Oral lesions in people with tuberculosis are seen only rarely. These lesions have been reported as ulcers on the tongue secondary to pulmonary tuberculosis. MAC has been reported to occur as a palatal ulcer and was in fact the first presentation of MAC in that patient.