Taking ecstasy with other hallucinogens like LSD can result in a person experiencing severe mental disturbances. Taking ecstasy while using some antidepressant medications can result in an extreme adverse reaction. Overall, the health risks increase when mixing ecstasy with other drugs, including alcohol , especially when large quantities are taken. Tolerance and dependence Tolerance to a drug occurs when a person needs larger amounts of a drug to achieve the same effects as smaller amounts. Research suggests that, while some people may develop tolerance to the effects of ecstasy, using larger amounts will increase the severity of undesirable effects, rather than increase the pleasurable effects.
Physical dependence occurs when a person's body gets used to functioning with the drug present.
If a person who is physically dependent on a drug suddenly stops taking it, they will experience withdrawal symptoms because their body has to readjust to functioning without the drug. At present, there is no conclusive evidence to either support or refute whether people can become physically dependent on ecstasy. Psychological dependence occurs when using a drug becomes more important than other activities in a person's life. There is evidence that people can become psychologically dependent on ecstasy. It can be very difficult for them to stop or decrease their use.