For example, there is the drug called chloroquin. Mosquitos were initally resistant, but now a large number aren't. Even if we do find a vaccine, how do we know how long it will work. There are 350 varieties of mosquito, and only 60 of them transmit the malaria parasite. We really need to have an ecological perspective woven into all of the work that we do in addressing infectious diseases.
Mosquito ecology is complicated.
There is much that could be done in terms of public health measures which would limit exposure. Bednets work now, but what if mosquitos develop of resistance to the insecticide on the bed nets. Also, how do you convince people to sleep under these nets every night, and to put their children under them. They smell a little bad, and they have to be re-dipped in insecticide every 6 months. Education is essential, and behavioral changes on the part of the people in areas where Malaria is endemic.