As this condition progresses there will be characteristic changes in the white matter. Similar to a CT scan, MRI produces pictures of the inside of the brain without surgery. Instead of X-rays, a magnetic field is used to visualize the brain. MRI is more sensitive than the CT scan in detecting loss of or irregularities in the brain's white matter. Findings are like those seen with the CT scan.
Histologic techniques use chemical stains to look at tissues under the microscope.
Peripheral nerve tissue shows degeneration of axons and demyelination. Although no globoid cells are seen, small tubular structures, or inclusions, can be found in Schwann cells, the myelin synthesizing cells in the peripheral nervous system. These inclusions may be cerebroside deposits. Biochemical enzyme assays . As previously mentioned, enzyme activity can be tested in the laboratory.