If you want more details you should subscribe to National Geographic, or better yet, Hunter's World. Beer bellied morons named Bubba hunt these things every day, and they often do it drunk. If they can survive an encounter with a wild beast, it shouldn't be any trouble for you.
Most mundane creatures are incredibly fragile.
In addition to the time honored technique of using ridiculously excessive guns, you can kill them by destroying their habitat, poisoning their foodstuffs, giving them disease, putting them in zoos, etc.