These in situs were produced through a collaboration with Dr. Gary Lyons . Nuclear expression of different NFI proteins in transfected HeLa cells. The proteins are HA-tagged for ease of analysis. It maps between the two deficiencies noted. Expression occurs only during embryogenesis and not in the adult worm.
Expression starts in a few cells and appears to spread throughout most of the embryo.
We are currently identifying the cell types in which nfi-1 is expressed. Kenneth Butz, M.Sc. Ph.D Nataliya Guryanova, Ph. Behrens, M., G. Venkatraman, R.M. Gronostajski, R.R. Reed and F.L. Margolis. NFI in the development of the olfactory neuroepithelium and the regulation of olfactory marker protein gene expression.