The two sets are shown below. The sequences with differences highlighted in red indicate which amino acid residues contribute to the effects on uptake and inihibitor binding for the different chimeras. The black domains are DAT sequence and light domains are NET sequence. Uptake results for DA and NE are shown here . The black domains are DAT sequence and light domains are NET sequence.
Red letters indicate active chimeras.
Km and relativeVmax for DA and NE uptake are here . Effects of inhibitors here .