Andrzej Marek Brzozowski A prerequisite for any crystallographic analysis is that well ordered single crystals of the macromolecule under study can be obtained. Although the number of protein structures determined has been steadily growing, many biologically important proteins resist crystallisation. The project is a multidisciplinary one, addressing different biological, physio-chemical and theoretical aspects of the problem. This collaborative framework is underlying the fact that the complex interplay of the different aspects of crystallogenesis makes any isolated approach to the problem very difficult.
New information acquired within each group is transferred to and used by the others.
YSBL is a part of an interdisciplinary team of ten European laboratories, which main objectives are to formulate rational protocols for protein crystallisation instead of trial-error procedures. Both their inherently simple design and flexible nature provide an experimenter with a logical platform for further optimisation and modification. Journal of Appl.