Research interests include clinical trials of new treatments for acute ischemic syndromes and adjuncts to percutaneous revascularization. M.D. This laboratory's interests are in the area of neural and non-neural control of the circulation. Current studies examine sympathetic neural and vascular function in sleep apnea. Another line of investigation is concerned with mechanisms of hypoxia-induced vasodilation. M.D. Research interests are focused on all aspects of cardiac arrhythmias.
Publications are in the area of syncope and sudden death.
Our most recent publications are in the area of sympathetic nerve activity and carotid sinus hypersensitivity. The current research focus is on biventricular pacing in congestive heart failure. David A. MacLean, Ph.D. Research interests include the relationship between protein, amino acid and ammonia metabolism in skeletal muscle during exercise and disease. Further interests include examining the mechanisms and stimulators involved in the exercise pressor reflex, as well as the regulation of blood flow during hypoxia and ischemia. To investigate these questions, Dr. MacLean employs a novel procedure, the microdialysis technique, for directly measuring and quantifying compounds in the interstitial space.