I molecules to form stable bonds with proteins. I molecule forms the main binding site for calreticulin. As a result, castanospermine also prevents calreticulin-MHC interaction. Two different tapasin alleles have been identified in the Caucasian population. The dimorphism is located between two domains that have Ig homology.
Many residues are the conserved.
Both tapasins are type I transmembrane glycoproteins. The N-terminal region of tapasin is required to stabilize the MHC class I loading complex. Cresswell P. Homepage. Park I, Guillemot F, Severac V, Auffray C, Zoorob R. 1999. Identification of the Tapasin gene in the chicken major histocompatibility complex.