Each method has its advantages and disadvantages. These are discussed below. Both are effective and generally well-tolerated. For a variety of reasons some women are unable to take oral estrogen. And in some rare cases, oral estrogens are ineffective and useless.
Many people find the pill form very convenient as it is something they are comfortable with.
However, it may not be the most efficient form of introducing hormones where you want it to be. Many pills disintegrate in the stomach, and may not enter into your system. Newer micronized products in oil base help protect the product from the acids in the stomach and helps the hormone make its way intact into your system for a better blood level. The daily dosage is much higher than in the cream form. The higher amount is necessary to compensate for the large percentage that is excreted by the liver.