Not used in patients with renal or hepatic dysfunction. Not used in patients with acute alcoholism, bronchial asthma, increased intracranial pressure, unstable cardiovascular status, respiratory depression and anoxia. Seizures may be aggravated or precipitated in patients with no history of convulsive disorders, especially in large doses. Seizure thresholds can be decreased. Use during pregnancy has not been established as safe.
Narcotics cross the placenta rapidly.
Consider risk verses benefit. Use with caution during lactation. Most narcotics are excreted in breast milk, usually in low concentrations. Consider risk verses benefit. Advise patients to wait 4 to 6 hours after administration before nursing.