Nemognathinae are unusual in that the SG larva and following pupa and adult are encapsulated by the cast but intact skins of the last instar FG larva and the C larva. Several alternative developmental pathways have been identified. Rarely, a larva pupates directly from the C phase. Presumably in response to adverse environmental conditions, larvae of several genera of Meloinae can return to the C phase after reaching the SG phase. Adults commonly live three months or more.
Females typically mate and oviposit periodically throughout their adult lives.
Cantharidin Blister beetles receive their common name from the ability of their hemolymph to produce blistering on contact with human skin. Hemolymph is often exuded copiously by reflexive bleeding when an adult beetle is pressed or rubbed. Blisters commonly occur on the neck and arms, as the result of exposure to adult beetles attracted to outdoor lights at night. General handling of adults seldom results in blistering unless the hemolymph contacts the relatively thin skin between the fingers. Taken internally or absorbed through the skin, cantharidin is highly toxic to mammals.