Roseola infections occur between 6 months and 2 or 3 years old, and are classicaly characterised by very high fever in a youngster who does not appear to be very ill.
Febrile seizures can result.
It appears mainly on the trunk but also to some extent on th extremities. The rash does not itch, and disappears without treatment in a day or two. HSV-6 probably is responsible for more disease than we have recognised in the past. This happens in the form of nonspecific viral illnesses with high fever that do not result in rash or result in variable rashes. Physicians are generally reluctant to investigate the exact viral cause of these illnesses because confirmation of the virus type would require blood antibody testing on two separate occasions several weeks apart, and the child is already long since well by the time the answer is in.