When you suspect depression in yourself or someone close to you, reach out for help. Genetic factors Some types of depression run in families, indicating that a predisposition could be inherited. Major depression seems to occur generation after generation in some families. It can also occur in people with no family history of depression. Biochemical factors Depression is also tied to disturbances in the neurotransmitters that control mood and activity level.
Neurotransmitters carry impulses between the nerve cells in the brain.
An imbalance in the amount or activity of neurotransmitters can cause major disruptions in thought, emotion and behavior. Any unwelcome change in life patterns can trigger depressive feelings. The loss of a job, death of a family member, financial problems and chronic illness can contribute to depression. Other factors Psychological makeup also plays a role in a person's vulnerability to depression. People that have low self-esteem, that consistently view themselves and the world with pessimism, or that are readily overwhelmed by stress are prone to depression.