Those with higher baseline levels who take the same regimen of supplement will have a lot of excess creatine in their system. It is thought that the excess creatine not taken up into the muscles is simply excreted by the kidneys, with no negative side effects. However, since creatine is a protein-like amino acid there are questions as to the actual effects of over dosage. The great protein debate falls into how much does protein actually help athletes. When excess protein is consumed it is either burned for energy or converted to fat.
Protein is less effective than carbohydrates at being burned for energy.
Excess protein may also lead to dehydration since the kidneys need more water to eliminate the excess nitrogen left by the extra protein. Aside from the risks of excess protein intake are risks from excess amino acid intake. The loading of certain amino acids may prevent the body from absorbing other essential amino acids. The amino acid levels can become unbalanced, actually leading to a loss of protein. Using amino acid supplements may also cause a deficiency of other nutrients typically found in protein-rich foods.