Go down Bryant Street. Left on 5th Street. Go 5 blocks to Mission Street.
Hotel is on far right corner.
It was a very good value based on other rates I could find in the city of San Francisco. The location was also ideal. Driving up to the hotel is a little scary as the outside and sign are old and made us insist on checking the room first which I've never done that before. Room was very quiet and well decorated. The Pickwick was the best hotel experience I've had in many years.