MD A pain medicine lessens the amount, duration, or sensation of pain.
Many pain medicines are available over the counter, without a prescription.
Prescription pain medicine Prescription pain medicines are available only with a prescription from a healthcare provider. Examples include phenytoin and carbamazepine. Common antidepressants include amitriptyline, trazodone, and imipramine. Common narcotics include morphine, codeine, meperidine, and oxycodone. These people should talk to their healthcare provider.