This mouse was named Scrambler. Mouse Dab1 is an intracytoplasmic adapter protein, which is thought to interact with tyrosine kinases of the Src and Abl families. Unlike reelin, mDab1 is expressed in the neurons that manifest the Reeler phenotype suggesting that it is a key element of the response to a reelin signal. The normal formation of the central nervous system involves a precisely orchestrated series of waves of migration of post-mitotic neurons from ventricular zones to their final anatomic locations. Joubert syndrome, pediatric epilepsy, schizophrenia and others.
Mice models help elucidate the neuronal migration abnormalities.
A protein related to extracellular matrix proteins deleted in the mouse mutant reeler. J Comp Neurol. Scrambler, a new neurological mutation of the mouse with abnormalities of neuronal migration. The lungs were diffusely discolored red and white with a nodular surface. There were multiple, firm, white, pleural nodules associated with the mediastinum.