And so the use of hormonal therapy in any one of a variety of forms can be very, very useful in controlling pain. There's actually an extraordinarily effective means of controlling pain. That's a very, very difficult and important challenge for the patient and the patient's family. So pain management there is really a major, major challenge for the physician and patient. Well, it really depends.
Pain can be a very, very important aspect.
For example, the onset of new back pain in patients with prostate cancer can really be potentially catastrophic, especially if it's not recognized and diagnosed early. For example, new back pain in a patient with metastatic prostate cancer can always mean the potential of spinal cord compression, and leading to paralysis as the cancer grows around the spinal cord, causes back pain. That needs to be treated immediately and urgently. Likewise, patients that have pain in their hip or other long bones are at increased risk for developing a fracture. So that needs to be assessed immediately and directly.