It is felt that RS is not a progressive disease, but is thought to be a maturational or developmental arrest during a period of dynamic brain growth when synapse connections are being formed and are interrupted. Synapses are one wiring system meeting another. Neurons send out axons. Connections can be made neuron to neuron or neuron to axon. Dendrites are branches in axons.
Neurotransmitters are chemical messengers.
For this reason, researchers are looking carefully at neurotransmitters and growth factors. As the inferior olivary nucleus is developed in the third trimester of pregnancy, this lack of development gives rise to the opinion that RS develops before birth. Organs which have been examined have also been found to be small. As those of you who have been around for awhile can attest to, we now know far more than we did a dozen or so years ago. This has only happened because of the courageous parents who consented to autopsy during their most trying time of loss.