Metronidazole is primarily an anaerobic bactericidal antibiotic and often shows dramatic clinical response in combination with prednisolone therapy in refractory IBD cases. Metroniclazole also has an antiprotozoan effect and aids in inhibiting cell-mediated immune responses in the intestinal tract. An average cat would receive approximately a quarter to a half of a 250-mg tablet two or three times a day. Additional immunosuppression may be necessary in cases that are refractory to prednisolone. Bone marrow suppression is a potential side effect of azathioprine therapy, and a CBC should be monitored every 2 weeks during the first month, then monthly thereafter.
Most cats tolerate the drug well.
Potential side effects in cats include anorexia and anemia. This drug must be administered more cautiously to cats than it is to dogs. If dietary allergens are a possible cause of IBD, a hypoallergenic diet is indicated. Long-term dietary management may be necessary in chronic IBD cases. Low-gluten diets that have been suggested include Science Diet Feline Maintenance.