An environmental factor that can cause thyroid enlargement, e.g., iodine deficiency, treatment with thiourea, and certain dietary plant products, including turnip, cabbage, kale and brussel sprouts. Graves disease Thyrotoxicosis associated with diffuse thyroid hyperplasia and non-nodular enlargement, i.e. toxic goiter . A microscopic focus of bone resorption in hyperparathyroidism. In these lesions osteoclasts excavate resorption pits into the surfaces of trabecular bone spicules. Adjacent bone surfaces are lined by fibroblastic marrow stromal cells, which differentiate into osteoblasts and fill in the resorption pits.
Osteoblasts secrete alkaline phosphatase causing a rise in serum alkaline phosphatase.
Instead of stimulating endocrine glands, it acts directly on somatic tissues, promoting their growth. HGH also causes hyperglycemia and may aggravate existing diabetes mellitus. Hurthle cell End stage or damaged follicular cell characterized microscopically by the presence of abundant, eosinophil ic, granular cytoplasm. This is the most common of all paraneoplastic syndromes . Not infrequently hematologic malignancies, esp.