The missing bone. Virus induction of osteosarcomas in mice. Possible involvement of the Fos protein in osteoblastic differentiation. Retinoic acid increases zif268 early gene expression in rat preosteoblastic cells.
Osteoblasts are target cells for transformation in c-fos transgenic mice.
An activating Gs a mutation is present in fibrous dysplasia of bone in the McCune-Albright syndrome. II A gene in vitro also interact with the SV40 promoter and enhancer regions. The product of a novel growth factor activated gene, fosB, interacts with jun proteins enhancing their DNA binding activity. A gene activated by growth factors is related to the oncogene v-jun. Heterodimer formation between CREB and Jun proteins.