Once all the data is entered save it in a file, preferably in the same folder in which EWOC was installed. In this case, save your revised data file each time so EWOC will have access to the updated version. Click OK on the banner. It would be set relatively high when the DLT is a transient, correctable or non-fatal condition, and low when it is lethal or life threatening. The probability that the dose selected by EWOC is higher than the Target dose.
Low values make the escalation cautious, high values cause larger steps.
In the beginning of a trial, there is a higher level of uncertainty about the Target dose. As the trial progresses, uncertainty about the Target dose declines and the likelihood of administering a dose considerably higher than the Target dose decreases. Thus, one should consider gradually increasing alpha during the course of the trial. The dose to be given to the first patient in the trial, previous results indicating this to be a safe dose. EWOC will never assign doses below the Initial dose.