Mucosal pseudomembrane formation may lead to mucosal scarring and loss of function of the involved organ system. Esophageal strictures may occur when extensive involvement of the esophagus exists. Mucosal shedding in the tracheobronchial tree may lead to respiratory failure. Ocular sequelae may include corneal ulceration and anterior uveitis. Vaginal stenosis and penile scarring have been reported.
Renal complications are rare.
A Caucasian predominance has been reported. Typically, the disease process begins with a nonspecific upper respiratory tract infection. Vomiting and diarrhea occasionally are noted as part of the prodrome. Mucocutaneous lesions develop abruptly. Clusters of outbreaks last from 2-4 weeks.