We study issues at the interface between virology and immunology, working from the hypothesis that viruses manipulate the immune response as the immune response attempts to eradicate the virus. Analysis of these issues is key to understanding chronic diseases caused by viruses. In addition, MCMV infection inhibits IFN g signaling in macrophages with consequent decrease in antigen presenting capacity. Murine gammaherpesvirus 68 encodes a functional regulator of complement activation. Leib DA, Harrison TE, Laslo KM, et al.
Interferons regulate the phenotype of wild-type and mutant herpes simplex viruses in vivo .
MacDonald MR, Burney MW, Resnick SB, et al. Spliced mRNA encoding murine cytomegalovirus chemokine homolog predicts a b chemokine of novel structure. Van Dyk L, Katz JD, Liu C, et al. 68 v-cyclin is an oncogene that promotes cell cycle progression in primary lymphocytes. Virgin HW, Presti RM, Li X-Y, et al.