People who develop fever, nausea, and rash while taking abacavir should contact their doctor immediately. If the symptoms are a hypersensitivity reaction to the drug, abacavir should never be taken again . These side effects do not develop in everyone who takes nucleoside analog drugs. In some cases, most of these side effects can be treated or will go away in time. Other protease inhibitors are in development.
Protease inhibitors are perhaps the most powerful anti-HIV drugs available.
But their side effects can be difficult to manage and in some people, may include the development of a syndrome called lipodystrophy . When people develop lipodystrophy, their body fat is redistributed in abnormal ways. When the changes happen, they can be physically uncomfortable and emotionally distressing. Scientists and AIDS experts are not sure what causes lipodystrophy, but since the protease inhibitors were approved, the syndrome has begun to develop more frequently, though it does not happen in everyone who takes a protease inhibitor Protease inhibitors can also cause metabolic disturbances . These disturbances may or may not appear together with symptoms of lipodystrophy.