My research program is centered in the fields of immunology and cancer biology. One component of the research focuses on cellular and molecular regulation of macrophage function. This work makes use of cytokines as well as lipid metabolites to assess pathways of signal transduction as well as effector functions of macrophages.
Gene regulation is studied by the use of ribozymes.
The other active program focuses on dietary fat and breast cancer, particularly mechanisms by which fatty acids modify metastasis. Specific projects center on angiogenesis as well as proteases produced by metastatic cells. Recent Publications Suk, K., D. Sipes and K.L. Erickson. Kisich, K.O., R.W. Malone, P.A. Feldstein, and K.L. Erickson. Specific inhibition of macrophage TNF-a expression by in vivo ribozyme treatment.