We are interested in the early signal transduction events that follow cytokine activation, such as activation of JAK kinases and STAT transcription factors, and in the later events, such as the induction of cytokine-specific genes. Recently, we have identified and cloned a family of cytokine-inducible deubiquitinating enzymes that regulate hematopoietic cell growth. These enzymes regulate growth by controlling the ubiquitin-mediated proteolysis of intracellular growth regulatory proteins. FA is a human autosomal recessive disease characterized by spontaneous chromosome breakage, bone marrow failure, and cancer susceptibility. The major focus of our laboratory is the elucidation of the proteins interacting with the FA pathway and the cellular role of this pathway in maintaining chromosome stability.
Fanconi anaemia forges a novel pathway.
The Fanconi anemia proteins, FAA and FAC, bind and form a nuclear complex.