ChromSword Auto ChromSword Auto- Automatic Method Development Software ChromSword Auto ChromSword is a chromatographic method development software supporting the rapid development of separation methods in liquid chromatography with minimum experimentation. All the well established relationships of traditional HPLC method development between retention of compounds and chromatographic conditions are handled within the ChromSword program, relieving users from complicated, tedious or expensive method development tasks. After building the retention model, the software can simulate the results of other experiments under different concentrations of an organic solvent, thus allowing you to find acceptable conditions working with a computer. On the basis of a few experiments or only structural formula, users can computer-simulate many chromatographic experiments with different compounds, various columns and eluents and, finally, optimize conditions with a minimum of time for the chromatographic run.
Prediction is the first step in method development.
The subsequent steps are optimization of retention and separation. Users can optimize the concentration of an organic solvent in a mobile phase, pH value, temperature, gradient profile etc. To optimize the chromatographic process, users can enter retention data for two or more runs and ChromSword will find the best conditions for isocratic and gradient elution. ChromSword enables users to develop methods for complicated separations in record time. If the structural formulas of compounds are known, ChromSword can predict the optimal isocratic or gradient elution conditions for acceptable retention.