Michael Duchen, Eric Boitier, D. Jake Jacobson, Julie Keelan, Mart Mojet and Olga Vergun.
Mitochondria are also a site of free radical production.
The open probability of the channels that regulate ER or SR calcium release are modulated by sulphydryl groups susceptible to modification by free radical species. Such a mechanism may operate in a wide array of pathological processes, most obviously in reperfusion injury, but possibly also in glutamate toxicity and in some of the neurodegenerative diseases. We thank the Wellcome Trust and MRC for financial support.