Concurrent use of MAO inhibitors is contraindicated. The hypotensive effects of guanethidine may be reduced. Phenylpropanolamine may cause headache, dizziness, insomnia, nervousness or restlessness. Chlorpheniramine may cause slight to moderate drowsiness, dry mouth, dizziness, blurred vision, or urinary retention. The manifestation of chlorpheniramine overdose may vary from CNS stimulation to CNS depression.
Gastric lavage is recommended for treatment.
General supportive measures should be instituted for symptomatic treatment.