Do not pack anything fragile, valuable or perishable. Leave expensive jewelry at home. In your carry-on , pack toiletries, a change of clothes, as well as aspirins. Luggage Airlines regulations. Airlines typically allow no more than 2 pieces of checked luggage and one carry-on luggage .
Most airlines have weight and dimension limits.
Check with your airlines. It is a good idea to bring one packed suitcase and an empty duffel bag for items accumulated during the trip. Remember that you will be returning with significantly more that what you leave with. Type of luggage. Your first decision should be what kind of luggage to take.