Gymnemic acid is the active constituent extracted from the leaves of Gymnema sylvestre. Therefore, its effectiveness in reducing total calorie intake is questionable. Dong-Quai, an aromatic herb, has been widely used in Southeast Asia for centuries for its purported CNS stimulant effects. It is becoming popular in the United States as an ingredient in weight-control products. Pharmacological actions of coumarins include vasodilatation, CNS stimulation, and immunosuppression.
Photosensitivity seems to be a significant concern.
In another article in the same issue of Federal Register, there have been many complaints registered with the FDA concerning the misuse of OTC products containing ephedrine. These products have been misused as a stimulant, for weight control, and in athletic muscle building products. Ephedrine is also the substance used for the illicit production of crystalline methamphetamine. The agency will accept any comments on the proposed rule until August 28, 1995. A third H2 antagonist will be marketed for OTC sales.