The autonomic nervous system and catecholamines play a major role in the regulation of salt and water excretion by the kidney and are involved in the pathogenesis of hypertension, and edema formation in heart and liver failure. Hypertension and salt retention are complications of diabetes mellitus. Hyperglycemia stimulates salt transport in the kidney and modifies the second messengers used by catecholamines to regulate Na transporters. We are investigating the impact of high and low glucose concentrations on regulation of Na transport by catecholamines. Proximal tubular cells from normotensive and hypertensive rats with diabetes mellitus are used directly or after cell culture.
Endogenous dopamine regulates phosphate and citrate excretion.
Endogenous dopamine regulates phosphate reabsorption but not NaK-ATPase in SHR kidneys. The Effect of High Fructose Intake on Renal Morphology and Renal Function in Rats. Digoxin Reduces Cardiac Sympathetic Activity in severe Congestive Heart Failure. Baines AD and Drangova R. Regulation of sodium transport by endogenous dopamine production in proximal tubular and OK cells. Our research uses rats and isolated perfused rat kidneys to study the effects of molecular mass and oxygen affinity on the functional response to these synthetic blood substitutes.