And perhaps not an absolute extinction but a set-back of a billion years of machinery and atmosphere building is as good as a termination condition. One advantage is super charged selection, freed from the slow speed of chemical replication and limited supply lines of atoms, the essential genetic machinery can be copied relentlessly rapidly. Of course, the machinery of the ecosystem itself is still atomic and at this point extended relatively slowly by we the memetic partner. When the atomic support system is also spun by the genes of the digital biotes, the pace will pick up dramatically. One other distinct advantage of digital biota is lightspeed travel.
Massless organisms can escape gravity's well easily, and traverse the solar system in mere hours.
If Freeman Dyson is right the collective surface of the Oort cloud, Kuiper belt and various comets and asteroids may be the largest and most fertile surface for ex-terrestrial life. Clearly humans are poorly adapted to a hard vacuum. Preceding us into these realms will need be countless infrastructure builders better suited for life there. And at least some of Eath's biological eggs will be out of the proverbial single basket. This would be a wonderful legacy that humankind could leave from its time in the biosphere.