During the winter months the tree enters a deep dormancy. The roots as well are dormant, rare among deciduous trees, so transplanting should be done in the spring after the tree has broken its dormancy, otherwise damage to the roots may result in fungal infections and root rot. Transplanting can be trickey as pawpaws have extremely long taproots. Chose plants that have been raised in a container, this way the integrity of the taproot is reasonably ensured. Pawpaws must be cross pollinated for fruit to set.
Pollination is carried out by flies and beetles.
Bees seem to be uninterested in the flowers of the pawpaw. Pawpaws are easily propagated by grafting, but softwood and hardwood cuttings are difficult to root. Pawpaws may be grown from seed, provided the seeds are properly stratified. The pawpaw tree has few pests. North of Florida, Asimina triloba is the exclusive host for the caterpillar .