Weak bones of the skull are unable to adequately support the tooth roots leading to malocclusion of the cheek teeth. Sharp spurs on the overgrown cheek teeth injure and ulcerate the tongue and cheeks, making eating and swallowing very painful. Affected rabbits drool saliva soaking the neck and chest. Eventually it will be impossible for the rabbit to eat and progressive weight loss will be seen . Abscesses associated with the cheek teeth produce an obvious swelling on the face.
Infection involving the teeth and jaw carry a poor prognosis.
Removal of one or more cheek teeth is difficult and extremely traumatic for the rabbit. The upper cheek tooth roots are closely associated with the eye sockets and tear ducts. Infection of tooth roots can lead to eye problems and blocked tear ducts. This typically presents as a watery or milky white occular discharge. Uneven wear of the molars will make chewing difficult.