The nose has a pinched root and a thinner, higher root. In the older adult, there are prominent nasolabial folds, and a high anterior hairline. Other less common anomalies have been described. No anomalies of note. However, pubertal development may be altered or delayed in some males with incomplete secondary sexualization and impaired or deficient spermatogenesis.
Nipples are relatively low-set and axillary webbing persists into adulthood.
Several patients with Noonan syndrome have had neurofibromatosis. Recent studies suggest that the gene for neurofibromatosis segregates with this phenotype. Fourteen of these 19 were noted to fill within the mildly retarded to borderline range. For these individuals, IQ scores ranged from 64 to 127. Only one individual's performance fell within the mildly retarded range.