Check the spare. Find rest stops on the map and plan to stop every few hours to stretch, unwind, etc. Don't try to cram too much in. Pick out a few points of interest and leave the rest for next time. Just a couple hours' break can make a world of difference .
Most people take far too much.
A few changes of clothes, basic toiletries, a camera, and a few other items are all you need. Very do-able if you obey the previous tip. Be organized . The more footwork you can do ahead of time, the more you can relax on the trip. Stuff happens .