Caution should be exercised in patients with hepatic insufficiency. Abrupt reduction or withdrawal of entacapone may lead to the emergence of signs and symptoms of Parkinson s Disease, as well as hyperpyrexia and confusion resembling neuroleptic malignant syndrome. The manufacturer recommends withdrawing patients from entacapone therapy slowly. Entacapone is classified in Pregnancy Category C and should only be administered during pregnancy if the potential benefit outweighs the potential risk to the fetus. Caution should be exercised when entacapone is administered to nursing mothers.
Food has no effect on entacapone pharmacokinetics.
0.5 mg single dose ampules Astra Pharmaceuticals Budesonide is an anti-inflammatory corticosteroid. Pulmicort Respules is an inhalation suspension indicated for administration via jet nebulizer in asthmatic patients 12 months to 8 years of age. The frequency of adverse events does not increase when budesonide is administered with other drugs that are commonly used to treat asthma. Coadministration of ketoconazole may increase plasma levels of budesonide, although the clinical significance of this interaction is not known. Pulmicort Respules is contraindicated as the primary treatment of status asthmaticus or other acute episodes of asthma where intensive measures are required.