Without both factors there is no risk.
Gasoline is a good example.
We know that it is toxic if ingested or inhaled, but if we take care to limit our exposure to it and handle it safely, we take little risk in using it. The same is true with pesticides. Dermal exposure is the most common type of exposure for the applicator since the skin is easily exposed when handling pesticides. Inhalation or breathing a pesticide into the lungs is less common, but is still a potential danger to the applicator. Ingestion occurs least frequently with careful applicators, but exposures do occur when users eat, smoke, or drink around pesticides or forget to wash after use.