Sport hunting is permitted in the preserve in accordance with state of Alaska and federal regulations. Big game animals present include Dall sheep, caribou, moose, black and brown bear. The park is closed to sport hunting. The airstrips at Port Alsworth are privately owned. Many acres of land within Lake Clark National Park and Preserve are privately owned.
Residents practice a subsistence lifestyle.
Most of Lake Clark National Park and Preserve is wilderness. While in the backcountry it is not unusual to never see another party. It is imperative that backcountry users be self-sufficient and have the knowledge and skills for safe wilderness travel. Use care in selecting campsites away from game trails and bears. Cache all food and scented items away from campsites.