Our goal is to understand both the intracellular signaling pathways and transcriptional control mechanisms involved in control of this receptor. Another complex of cell surface proteins which are important in control of cardiac function, as well as muscle and nervous system function, are the voltage-gated calcium channels. These channels, together with other ionic channels, control electric signal generation and transmission in these tissues. Our goals in these studies are to understand the molecular basis of the heterogeneity of ionic channel function, and to provide structural insight into the function of these channels. Developmental expression and regulation of smooth and skeletal muscle alpha-trpomyosin.
Distinct factors bind to apparently homologous sequences in the immunoglobulin heavy chain enhancer.