Fill in the blank 26. Since the channel is an integral membrane protein it can only be extracted by dissolving the membrane in detergent. Trypsin cannot be used because it will degrade the protein. A patch clamp cannot be used either because it will not extract the protein away from the membrane. It acts as a gate to open and close the channel in response to changes in voltage across the membrane.
Histones possess and unusually high content of the basic amino acids arginine and lysine.
Histones are highly conserved proteins that interact with DNA to form the basic packing unit in the nucleus, the nucleosome. The core of the nucleosome is an octamer of histones with two copies of each of four types of histones, H2A, H2B, H3 and H4. Two rounds of DNA wind around this core. A fifth histone, H1, interacts with the wound DNA to further stabilize the complex. Explain how these basic amino acids contribute to histone function.