He hallucinates off and on and believes people are spying on him. Higher brain function and physical coordination are steadily decreasing. He was recently prescribed Clozaril but his family is concerned that the side effects may outweigh the benefits of the drug, due to his present health. Hence, clozapine, which has minimal effects on D2 receptors and rarely causes EPS, is a logical choice for treating psychotic symptoms in PD patients. Journal of Neuropsychiatry and Clinical Neuroscience vol.
Hypotension needs to be monitored closely.
Agranulocytosis, of course, is a risk with clozapine.