New MBs have the USB running all of the time. With rare exception, you can't turn it off. So make sure that you account for its resources and install the drivers correctly. This is a very new feature for any motherboard. The BIOS doesn't see the card to assign any resources.
Results can be tragic.
Cards on the PCI bus don't work because an invisible ISA card uses the same interrupt. This still happens more than you would think. These have jumpers for address and IRQ settings. The card is free, so you can't moan too much. A PCI card will try to use the same IRQ without some help.