Food reduces the rate and extent of temozolomide absorption.
Temozolomide is rapidly eliminated with a mean elimination half- life of 1.8 hours and exhibits linear kinetics over the therapeutic dosing range. 4 thrombocytopenia in the first cycle of therapy than patients under 70 years of age. In the entire safety database, however, there did not appear to be a higher incidence in patients 70 years of age or older. Women have higher incidences of Grade 4 neutropenia and thrombocytopenia in the first cycle of therapy than men. The effect of race on the pharmacokinetics of temozolomide has not been studied.