The level of renal kallikrein excretion is diminished in essential hypertension. Estrogen receptors are higher in varicose segments than It has not been determined if these differences are age nonvaricose segments of the same vein, especially in females. In male athletes. Jordan et al. Swan et al.
Elderly people metabolize the verapamil enantiomer more slowly than young people.
The endothelial synthesis of nitric oxide from L-arginine is stimulated by acetylcholine. The vasodilating effect of the brachial artery administration of acetylcholine was markedly impaired in hypercholesterolemic males but not hypercholesterolemic females compared with the effect in eucholesterolemic controls. Positron emission tomography scans after rectosigmoid balloon distension show differences and may help elucidate the reason for the sex differences. The biological basis for this difference is unknown. An example of a pharmacokinetic, not a pharmacody- namic, difference.