Hyperuricemia may occur in patients receiving pyrazinamide, but acute gout is uncommon. Asymptomatic hyperuricemia is not an indication for discontinuing the drug. Ototoxicity and neprotoxicity may occur in patients receiving streptomycin. Audiometry should be performed at periodic intervals during streptomycin therapy. If vertigo, dizziness, or ataxia occur in patients taking streptomycin, the drug should be discontinued immediately.
Optic neuritis is the most frequent and serious adverse effect of ethambutol.
Baseline and monthly tests of visual acuity and color vision should be conducted. Current literature and package inserts should be consulted for other possible drug reactions.