Meadow mice nests are globular structures of dry grass about six to eight inches in diameter. Nest cavities usually are located on the ground surface, under old boards, discarded metal, logs, or other such cover. In winter, above-ground nests sometimes are made in deep snow, but these temporary nests are vacated when the snow melts. Mating begins in the spring, as soon as weather moderates and plant growth starts, and continues into the fall. Females are capable of reproducing at the age of three weeks, and litters of two to nine young are produced monthly.
Natural forces control the number of meadow mice.
Coyotes, foxes, weasels, skunks, hawks, owls, dogs and cats all prey on meadow mice. In the absence of mice, these predators might turn to other prey more valued by man. In unfarmed areas where woody plants encroach on grasses and weeds, habitat for meadow mice is less hospitable. Fires, floods and crop rotations also take heavy tolls of meadow mice. Regardless of limiting factors, meadow mice can become so plentiful that they damage crops and ornamental plants.