The stem just below the surface, called the rhizome, and the long and slender roots are the parts used by herbalists. The tonic effect of goldenseal is of healing value to the liver. Also, by combining it with bicarbonate of soda, goldenseal is an excellent mouthwash for the relief of sores in the mouth and of the gums. It is recognized as a superior aid for sore throat. And it has been used by doctors for ulcers of the vagina and uterus, as well as eczema and smallpox.
Goldenseal root is antiseptic and hemostatic, which means it stops bleeding.
It is used as an effective eyewash and brewed as tea for stomach aches. But goldenseal root is very poisonous in large doses and should not be taken internally without medical supervision. Goldenseal has been found to contain alkaloids hydrastine, and berberine. These are astringent and have antibiotic properties. Herbalists consider goldenseal one of the best herbs around.