Researchers discover gene that regulates 'good' cholesterol. The gene, ABC1, was discovered while researching Tangier disease. Tangier disease is a rare disorder in which the body produces no HDL cholesterol, leading to heart attacks and clogged arteries.
Researchers discover gene that regulates 'good' cholesterol.
Brooks-Wilson, A., et al. Mutations in ABC1 in Tangier disease and familial high-density lipoprotein deficiency. Tangier disease is caused by mutations in the gene encoding ATP- binding cassette transporter 1.