There are many ways to take estrogens and many philosophies of management. The ultimate decision and responsibility for medical management is between you and your health care practitioner. Each woman is unique and each woman has different needs at different times in her lifetime.
Lets start with some basic biology.
Throughout the body, there are cells which respond to stimulation by estrogen. These cells are found in the brain, breast, skin, liver, uterus, vagina, and bladder as well as other site. On the surface of these cells are small areas called receptors. A receptor is like a keyhole. Interestingly enough, when there is a lot of a substance around for a long period of time, more receptor sites become established.