This sparked interest in the correlation between the nervous system and the immune system of the body. A macrophage then engulfs the pathogen. These regulate the production of complementary adhesion molecules to the cohesion molecules on the walls of the brain, causing T-cells to bind to them. After another round of proliferation, new T-cells bind to microglia and cause the release of more and more cytokines. At this time there is more and more binding of the T-lymphocytes occurring to microglia.
Macrophages complete the process by stripping the myelin sheath directly off the nerves.
The replication of T-cells, the secretion of more and more cytokines, and the eventual destruction caused by the macrophages is cyclic. The myelin can be come inflamed, swollen, or even detached from the nerve fibers. Some of these cells are activated, belonging to T-helper cells. These underwent electrophoresis, and displayed oligoclonal banding. However, what the trigger for such an immune response is still unknown.