The assembly and fusion events are potentially important targets for drug therapies directed against enveloped viruses such as, influenza, HIV, Ebola, etc. Failure of tumor suppressor genes to function properly causes uncontrolled cell growth leading to cancer. Expression of TSLC is abrogated or reduced in non-small cell lung cancer, hepatocellular carcincoma and pancreatic cancer cells. Our objective is to understand the normal functions of TSLC and the consequences of its inactivation in cancer cells. M. Kuramochi, H. Fukuhara, T. Nobukuni, T. Kanbe, T. Maruyama, H.P. Ghosh, M. Pletcher, M. Isomura, M. Onizuka, T. Kitamura, T. Sekiya, R.H. Reeves and Y. Murakami.
G enables mutant virus attachment and entry.
D.B. Anderson, S. Laquerrie, K. Ghosh, H.P. Ghosh, W.F. Goins, J.B. Cohen and J.C. Glorioso. Pubmed Role of the membrane anchoring and cytoplasmic domains in intracellular transport and localization of viral glycoproteins. K. Ghosh and H.P. Ghosh. Pubmed Effects of double-site mutations of vesicular stomatitis virus glycoprotein G on membrane fusion activity. S. Shokralla, R. Chernish and H.P. Ghosh.