Burley tobacco remains the main cash crop, with slightly more than six million pounds produced last year. Much of the farm land in Clark County is classified as highly erodible, and must be managed carefully to prevent erosion and keep the land productive. The soils and climate are especially suited for the production of forages. Some of this forage is harvested as hay and sold, but most is fed locally. The predominant livestock enterprise is beef cattle, with over 50,000 beef animals in the country.
Horses remain an important part of the agriculture of the area.
There is a small but growing number of more exotic livestock, such as llamas, ostriches, emus, and bison. Commercial vegetable production is growing slowly but surely into an important part of the local economy. Industrial hemp was once a major cash crop in Clark County, but is currently illegal in the United States, and there are serious questions about how profitable it would be if it were permitted. The Southern States Co-operative operates a grain purchasing facility along with its feed mill. This provides a local outlet for harvested grain.