Rarely does treatment need to be stopped because of these side effects, but if you still have these symptoms after taking the medication regularly for a few weeks, contact your doctor. Alcohol Intolerance Sulfonylureas may cause alcohol-intolerance reactions. Within 10 to 30 minutes of drinking a beverage or medication containing alcohol, some people get headaches, develop flushing or tingling in the face, and they may feel nauseated and lightheaded. These symptoms may last up to one hour. Alcohol intolerance can occur with any sulfonylurea.
People taking chlorpropamide or tolbutamide are particularly susceptible.
It's less of a problem with glyburide, glipizide, and glimepiride. To avoid future reactions, simply avoid alcohol. Check your medications, too. Some cold remedies contain as much alcohol as wine. Skin Sulfonylureas may cause mild skin reactions, including rash, itching, and hives.