Rifampin and INH are most capable of preventing resistance. The use of higher dose of the TB drugs to treat moderately resistant TB has not been systematically studied. Patients treated with INH may receive vitamin B6 to reduce the incidence of peripheral neuropathies. It is possible to cure selected cases of TB with use of just 3 months of INH and RIF treatment. When intermittent TB therapy is used, DOT is recommended.
Patients can be sputum smear negative and culture positive.
In HIV-positive patients where INH and RIF cannot be used, treatment duration become 12 months, regardless of immune status. Levofloxacin is typically added to INH, RIF, and PZA at the start of the therapy until the susceptibility information is available. Ciprofloxacin should be avoided in renal impair TB patients. Latent TB infection can lead to reactivation o disease years after the primary Infection occurs.