Genetic and Environmental Risk Factors for Cancer Polymorphic metabolic genes can confer enhanced genetic susceptibility to certain environmental carcinogens and modify the risk associated with exposure. Taioli et al. An analysis of epidemiological studies for this type of exposure-gene effect is illustrated by hypothetical data or examples from the literature. A model of risk assessment for humans exposed to ultraviolet B radiation was developed by Goettsch et al. Education and dust control aimed at high risk children were effective intermediate remedial measures for reducing lead exposure while major source control measures at the mining site are being implemented.
Plant estrogens competitively inhibit enzymes in women that convert androgens to estrogens.
Kao et al. The acute effects of ozone, fine particulate matter, and aerosol acidity on pulmonary function in adult hikers were determined by Korrick et al. Hikers with asthma showed a fourfold greater responsiveness to ozone than others and also exhibited greater air-pollution changes in pulmonary function.