With it on, however, if you have any sort of tool selected, and you try to go up to the menu bar to click on anything, you end up panning a long way from where you were working. Then there's the coordinate system for the PCB editor. So if you want room to add dimension lines, etc., to your PCB outline drawing, you need to have the board up off the origin. But, every time you run the autorouter, you're supposed to reset the origin back to the default. To recover from the above problem, I tried to restore the board from the backup copies that Protel keeps as you go.
Printing is a rather interesting exercise.
For example, if you switch from portrait to landscape, the first rebuild still shows everything in portrait. Oh, and true to form, the PCB editor prints entirely differently than the schematic editor. They seem to mostly happen when using the print utilities or when exiting Protel. They're pretty common when doing the above. At least with NT, it has yet to crash the OS, just itself.