NO signaling is essential for pathogen defense pathways in plants. Animal aconitases play an important role in regulating cellular metabolism in response to oxidative stress and in regulating iron homeostasis by controlling translation of iron-responsive genes. It remains to be determined whether the plant aconitases have similar functions.
Nitric oxide modulates the activity of tobacco aconitase.
On the basis of the combined use of dihydrorhodamine 123 and NOS inhibitors, the analysis of the amount, time course and nature of the species involved supports the view that PN generated from cNOS-derived NO, while not affecting cell viability and hepatocyte monolayer development, is the main species likely responsible for the early biochemical injury commonly observed in hepatocyte cultures. Endogenous nitric oxide is responsible for the early loss of P450 in cultured rat hepatocytes . Lopez-Garcia MP Department of Biochemistry and Molecular Biology, Facultad de Farmacia, Universidad de Valencia, Spain. These effects can be reverted by the sole addition of NO biosynthesis inhibitors during liver perfusion and early culture hours, which allows catalytically active P450 to be preserved at levels close to those of the intact liver. Pitfalls of SNP Related Articles Apparent role of hydroxyl radicals in oxidative brain injury induced by sodium nitroprusside.