Crypts are lined by mature columnar cells and goblet cells. Paneth cells are often present. The goblet cells secrete sialo- and occasionally sulphomucin. Paneth cells are rarely observed. Distortion of crypt architecture is more pronounced and loss of differentiation and cellular atypia are more marked than in type 2.
Paneth cells are usually absent.
Characterised by columnar mucous-secreting cells and goblet cells resembling colonic mucosa. It has also been interpreted as a phenotypic change related to one hostile microenvironment, impaired maturation or aberrant differentiation along ileal and colonic cell lines. In a large cohort study it was shown that type 3 IM is closely associated with gastric carcinoma of intestinal type, and within IM it is a more selective indicator of cancer risk. Types I and II are prevalent in both benign and malignant conditions, and are thus not useful as markers of cancer risk. Index de la page .