The occurrence of peripheral neuropathy is frequent. As dose increased, the symptoms also tended to increase. Therapy should be stopped when the symptoms are first observed. It may be more severe in those who are getting higher doses or more frequent doses than recommended. The results may be irreversible.
Paresthesia means numbness, prickling, or a tingling, heightened sensitivity.
Peripheral neuropathy is more likely to occur in those taking continuous high doses of Hexalen than in those taking lower doses or on an intermittent schedule. It may worsen Cisplatin related neuropathy. Neurologic toxicity has been reported to be reversible when Hexalen is stopped. When these occur, dosage must be adjusted. If symptoms persist, treatment should be discontinued.