No marketing guru is making a million dollars a month because he can figure out from your subscription to a particular Mailing List that you are an aging, balding sexual pervert. Believe in coincidence, if it helps. As long as people respond positively to the message, spamming will continue. The downside is that you can't reply to the spam and flame the sender, because they always use some fake e-mail address or an anonymous pseudonym. So the best bet is to grit your teeth and ignore the message.
Marketers hate to be ignored.
Some Cautions Mailing Lists can be highly addictive. If you're getting over 200 messages per day from ten different Mailing Lists, you may be overdoing it. It could take way too much time to sort through all the chaff to get to those kernels of wheat. So use caution, and don't be afraid to unsubscribe should the time come. Note also that there are ebbs and flows to the material on a list.