In humans fever and arthralgia are common prodromal signs. Erythema develops within hours or days. The initial erythema is usually overlooked in small animals. Fever, lethargy, malaise and anorexia are common in dogs. Many cases present with patches of full thickness sloughing with widespread mucosal ulceration.
Mortality is high due to secondary bacterial infections and electrolytes loss.
This disease is a hereditary idiopathic and inflammatory condition of skin and muscles of young Collies and Shetland sheepdogs. The exact cause of this disease is unknown but an immune-mediated pathogenesis is suspected since affected dogs often have high levels of circulating immune complexes. A familial history is common. Erythemas, scaling, crusting, and ulceration may be seen on the face, tips of the ears, tip of the tail, and periocular area. Oral and footpad lesions can be seen but are rare.