Many people report feeling depressed after taking ecstasy.
Most often this depression is mild and lasts only a day or two. However, some regular users report feeling depressed for much longer periods of time after taking E, particularly if they use it frequently or take large doses. At the same time, most people who use Ecstasy do not report experiencing depression. A Possible Physiological Explanation MDMA works by releasing from certain brain cells large amounts of the brain chemical, serotonin. This release of serotonin is what causes Ecstasy s mood elevation effect, as well as the feelings of empathy, self-acceptance, and emotional closeness with others that so many people find valuable and rewarding about the drug.