The recommended initial dose of candesartan is 8 mg once daily, to be taken with or without food at approximately the same time each day. Tolterodine is a competitive muscarinic receptor antagonist which inhibits detrusor muscle contractility. The initial recommended dose of tolterodine is 2 mg twice daily with or without food. The dose may be reduced to 1 mg twice daily, based on individual response and tolerability. The 1 mg twice-daily dosage should be used for patients with significantly reduced hepatic function.
Dry mouth is the most frequent side effect of tolterodine therapy.
The drug is contraindicated in patients with urinary retention, gastric retention or uncontrolled narrow angle glaucoma. The product is indicated for the prevention of osteoporosis in postmenopausal women. The recommended dosage is 60 mg once daily, with or without food. Raloxifene provides the beneficial effects of estrogen on bone and lipids, without any negative estrogen effects in the uterus and breast. It increases bone mineral density better than placebo or calcium supplements, but less than estrogen.