If samples are required on affected family members who are no longer available, DNA can be collected on stored paraffin blocks. The gene is tracked by using 3 closely related highly polymorphic markers. The DNA from the BRCA2 gene is analyzed by sequencing in order to identify the mutation. Basic pedigree detailing cancer history. Involvement in the appropriate IRB-approved protocol.
Genetic counseling is available for all members of the families undergoing testing.
Stored paraffin blocks of affected family members who are no longer available. A Requisition form should accompany the specimen.