A project to develop a specific instrument or procedure will generally involve iteration between modeling and experiment, converging on a set of optimized design parameters. LLNL has unique capabilities for multiprocess modeling. Stress waves can be used to locally modify or disrupt tissue. The index represents the density in the stress wave. Such comparisons have verified the model and now we are using it to design more sophisticated stress wave delivery systems.
Experiments validate the simulated skin surface temperatures.
These validated simulations provide subsurface temperature predictions that cannot be experimentally measured. Skin surface temperatures are accurately predicated through the use of modeling. Stresses associated with the expansion and collapse of the bubble can be used for tissue emulsification and removal. The models have been used to design a system for treatment of stroke by removal of intravascular blood clots . It will allow more realistic calculations of clinical procedures.