Patients suffer from an overall failure to thrive and an increased risk of lymphoma.
We used sera from Celiac patients to demonstrate the presence of mammalian proteins with partial gliadin immunological cross-reactivity, but searching the DNA databanks revealed no such proteins. The lab therefore undertook a gliadin cDNA screen of human cDNA and genomic libraries. Four distinct cDNA clones were obtained, the most stringent of which were novel and homologous to EST's. Genomic screening uncovered sixteen positives, one of which was the 'All1-Related' gene whose similarity to three of gliadin's five domains was remarkable. We mapped genomic clone 2 by FISH to 19q13.11 - 13.12, a suspected hot spot in Celiac disease.