Likely quite a bit. There is no information to date as to the genetic variation within this pattern recognition system but given our knowledge base, it is likely that some elements may prove to be susceptibility factors that predispose to the generation of autoimmunity. Suggested Reading Medzhitov , R and Janeway Jr, C. Innate Immunity. Anderson , K. V. Toll signaling pathways in the innate immune response. Janeway , C. A., Jr., and R. Medzhitov.
Lipoproteins take their toll on the host.
Ulevitch , R. J. Toll gates for pathogen selection. Aliprantis , A. O., R. B. Yang, M. R. Mark, S. Suggett, B. Devaux, J. D. Radolf, G. R. Klimpel, P. Godowski, and A. Zychlinsky. Modlin, R. L., H. D. Brightbill, and P. J. Godowski. All information contained within the Johns Hopkins Arthritis Center website is intended for educational purposes only. Physicians and other health care professionals are encouraged to consult other sources and confirm the information contained within this site.