A shortage of Dopamine in the frontal lobes may contribute to poor working memory. More dopamine into the frontal lobe lessens pain and increases pleasure. Endorphins - mediate pain at receptor sites. In an injury receptors in skin make electrical signals that goes up the spinal cord to the brain. The brain then evaluates pain by releasing pain killers called endorphins which bind at opiate receptor sites of neurons to mediate pain.
Endorphins effect the dopamine pathway that feeds into the frontal lobe.
These pathways inhibit the flow of dopamine. Vast quantities of endorphins are released and nerves are shut off so more dopamine flows through pathway to get to frontal lobe therefore replacing pain with pleasure. The system is activated by motivated behavior and arousal, and it influences the endocrine and autonomic motor systems. Neurons - the fundamental cellular unit of the nervous system, consisting of a nucleus with all its processes and extensions. Neurons function in initiation and conduction of impulses.