These pages are best viewed with Netscape version 3.0 or higher or Internet Explorer version 3.0 or higher. When viewed with other browsers, some characters or attributes may not be rendered correctly. Analyses of such data then use a variety of model-free approaches that rely on the expected increased allele sharing for affected pairs at loci involved in the disease.
Power is a function of the number of sibling pairs available.
It is also a function of the density of the genetic map used, the number of hypothesized disease loci, whether the data are restricted to sibling pairs where at least one parent is unaffected, the manner in which allele frequencies at the marker locus are estimated, and the statistical procedure chosen. The principles apply to other common diseases as well. It is anticipated that the joining of genotyping technology, appropriate statistical techniques, and adequate pedigree data will lead to the identification of specific genes for the common diseases and result in understanding that will lead to preventing or slowing the onset and development of these diseases. Diabetes Reviews V5.