The steady state volume of distribution of tirofiban ranges from 22 to 42 liters. The recommended regimen of a loading infusion followed by a maintenance infusion produces a peak tirofiban plasma concentration that is similar to the steady state concentration during the infusion. In patients with mild to moderate hepatic insufficiency, plasma clearance of tirofiban is not significantly different from clearance in healthy subjects. Tirofiban is removed by hemodialysis. The time course of inhibition parallels the plasma concentration profile of the drug.
Inhibition persists over the duration of the maintenance infusion.
These trials are discussed in detail below. Patients who were medically managed or who subsequently underwent revascularization procedures were studied. All patients received concomitant aspirin unless contraindicated. This arm was stopped when the group was found, at an interim look, to have greater mortality than the other two groups. The results are shown in Table 1.