The long term goal of studies in my laboratory is to understand the role of lipid biomediators, in neuronal degeneration. These studies suggest that lipid biomediators, in particular LPA likely play a role in neuronal degeneration. Lysophosphatidic acid-induced signals in astrocytes. Keller, J.N., Steiner, M.R., Mattson, M.P. and Steiner, S. M .
Lysophosphatidic acid decreases glutamate and glucose uptake by astrocytes.
Lysophosphatidic acid decreases glutamate and glucose uptake by astrocytes. Lysophosphatidic acid induces a sustained elevation of neuronal intracellular calcium. Lysophosphatidic acid induces necrosis and apoptosis in hippocampal neurons. Mitochondrial manganese superoxide dismutase prevents neural apoptosis and reduces ischemic brain injury suppression of peroxynitrite production, lipid peroxidation, and mitochondrial dysfunction.