We hypothesize that LPS interacts directly with microvascular endothelial cells to modulate arachidonic acid metabolism in these cells. This response is part of a general cellular response termed innate immunity.
Innate immunity is a nonspecific, first-line response to bacterial and other pathogenic challenge.
This production is due to enhanced transcription of the message for prostaglandin endoperoxide synthase-2. Our research interests also include an evaluation of the mechanisms by which LPS may interact with the endothelial cells to initiate the expression of prostaglandin endoperoxide synthase. Flynn, J.T. and H. Hoff. Flynn, J.T. Endothelium-derived eicosanoids and inflammation. Examining the Role of Eicosanoids and Procoagulants.