An individual patient is always advised to consult their own physician. Permax belongs to a class of drugs called dopamine receptor agonists. In general, tolerance does not develop.
Most side effects center on the nervous system- anxiety, hallucinations, dyskinesis, etc.
Nausea and vomiting are also seen. Long term side effects do not seem to differ markedly from short term side effects. It makes me sick almost every time I take it. There are a couple of different ones, but they all have the side effect of nausea. Try decreasing the dosage somewhat, usually all that works.