Studies have shown that ingestion of oral creatine improves repeated maximal exercise performance, benefits recovery from exercise and increases energy availability in healthy subjects. Creatine has been shown to have a positive effect in laboratory ALS mouse studies. This is a 9-month study .
Enrollment is open at all sites.
Muscle strength and size as well as breathing capacity will be monitored as to their response to the creatine trial. This study is designed to look at the short term, as well as, long term effects of creatine use. Quantitative muscle testing is done weekly for the first three weeks. It is then followed monthly for the next four months and bimonthly for the remainder of the nine-month study. The study also monitors purposeful exercise to determine if this enhances the benefit of creatine usage on muscle strength.