The collection of contemporary art covers a select number of artists. Only five works of art have a permanent location in the contemporary art section. The museum maintains an active exhibition programme in which a number of presentations and collections alternate simultaneously with each other. The museum also houses a number of smaller collections, including Maastricht earthenware and silver. The museum outlines the natural history of South Limburg.
Modern displays offer an insight into both the recent and distant past.
Among the museum's highlights are the remains of enormous Mosasauriers and Giant Turtles found in marlstone at the St Pietersberg caverns. Fossils of all shapes and sizes show how South Limburg has changed in the course of the last 300 million years. The natural features of the modern-day landscape are explained using startling visual projections, computers and aquaria. Before construction of the new Derlon Hotel was commenced, Maastricht's city archeologist undertook an extensive survey of the site. The Roman finds, from the 2nd, 3rd and 4th centuries, are so important that it was decided to conserve them and exhibit them to interested parties.