Prophylactic systemic antibiotics are not useful, especially in the current era of multiple-drug resistance. Antimicrobials are indicated in cases of urinary tract or cutaneous infections, either of which may lead to bacteremia. Some authors recommend daily follow-up. Some patients may require the services of a burn unit. Transfer criteria would be the same as for patients with thermal burns.
Recurrences are possible.
The majority of patients recover without sequelae. Development of serious sequelae, such as respiratory failure, renal failure, and blindness, determines prognosis in those affected. The gravity of the diagnosis must be recognized. Because patients with SJS who present early in the development of the disease may not yet be critically ill, the clinician may misdiagnose and discharge. SJS should be considered in all patients with target lesions and mucous membrane involvement.