Such symptoms include central nausea and vomiting, tinnitus and deafness, vertigo and headaches, mental dullness and confusion, diaphoresis, rapid pulse, and increased respiration and respiratory alkalosis. Treatment of acute salicylate intoxication includes minimizing drug absorption, promoting elimination through the kidneys, and correcting metabolic derangements affecting body temperature, hydration, acid-base balance, and electrolytic balance. The technique to be employed for eliminating salicylate from the bloodstream depends on the degree of drug intoxication. If the patient is seen within 4 hours of ingestion, the stomach should be emptied by inducing vomiting or by gastric lavage as soon as possible. The nomogram of Done is a useful prognostic guide in which the expected severity of salicylate intoxication is based on serum salicylate levels and the time interval between ingestion and taking the blood sample.
Exchange transfusion is most feasible for a small infant.
Intermittent peritoneal dialysis is useful for cases of moderate severity in adults. I.V. fluids alkalinized by the addition of sodium bicarbonate or potassium citrate are helpful. Hemodialysis is the most effective means of removing salicylate and is indicated for the very severe cases of salicylate intoxication. Bottles of 100 and 500. Bottles of 100 and 500.