The onset may be more rapid if the patient is rechallenged with the causative medication. The first step in the treatment of Stevens-Johnson syndrome is the withdrawal of all medications that are not absolutely necessary, especially if begun within 1 month of the onset of the eruption. Do not rechallenge the patient with any suspect medications. Skin biopsy may help to confirm the diagnosis and rule out other blistering diseases. Hospital admission may be appropriate, for hydration, nutritional support and monitoring for signs of infection.
Ophthalmologic care is essential to minimize ocular damage.
If the patient is to be monitored in an outpatient setting, careful follow-up is necessary as this syndrome may progress to toxic epidermal necrolysis.