It has been associated with intrauterine and acquired disease. Infection in man is acquired by inhalation, ingestion, or direct contact with virus found in the urine, feces, and saliva of infected mice, hamsters, and guinea pigs. Congenital LCMV infection is often an unrecognized cause of chorioretinitis, hydrocephalus, microcephaly or macrocephaly, intracranial calcifications, mental retardation, and seizures. Acquired LCMV infection is often asymptomatic but may cause CNS disease. Aseptic meningitis or meningoencephalitis is the predominant CNS presentation, but transverse myelitis, Guillain-Barr syndrome, and transient or permanent hydrocephalus may occur.
Fatalities are rare.
VCUG - To Wait or Not To Wait Vesicoureteral reflux is caused by incompetence of the ureterovesical junction and is the most common anomaly of the urinary tract in childhood. It is important to detect reflux in children with urinary tract infection because it allows ascent of the infected urine to the kidneys and predisposes to pyelonephritis and renal scarring. It is still commonly taught that an interval of 3 to 6 weeks after a UTI be allowed to pass before performing a VCUG based on the belief that acute infection leads to transient reflux. Investigators at Children's Hospital of Austin, TX reviewed the records of 213 children with confirmed UTIs and no other previously defined urinary tract pathology. The presence and severity of reflux and actual performance of VCUG were compared in the two groups.