It gets into the cells and activates it so that the body produces an immunological radical reaction which causes astronomical titers. People get sensitized to psyllium. If too many antibodies are produced, it can affect the kidney glomuerial filtering unit. It produces hormonal effects because hormones are flushed out. The reason it causes water to be brought into the gut is because the body is trying to inactivate the material.
Psyllium causes inflammation of the gastrointestinal tract.
That's the way it is. Burn hotter, make more oxygen radicals. No alternative in the known universe. If Psyllium Seed causes inflammation, it is because tissues with low vital energy are now able to respond properly. The same is true of legumes, Amaranths, Chenopodiums, grasses, etc.