Dysfunctional Uterine Bleeding . Dysfunctional Uterine Bleeding Definition Abnormal Bleeding defined as having no organic cause by the usual techniques of history, physical exam and pelvic examination.
Progesterone generates secretory endometrium and suppresses pituitary gonadotrope production.
If no fertilization occurs, reduced LH levels lead to progesterone withdrawal and menses. If fertilization occurs, hCG production from trophoblast continues to support corpus luteum until placenta is capable of producing adequate quantities of progesterone. Anovulatory DUB often obese, hypertensive, latently diabetic, at risk for adeno CA of endometrium. Perimenopausal pattern of DUB Related to impending ovarian failure. FSH tends to be elevated.