As to the theory that aggressive rehab and an active lifestyle might be responsible for the ultimate exhaustion of the neuromotor unit, Dr. Halstead says, It s possible, but there s no real evidence. Sometimes help is as simple as having the patient use a cane or a wheelchair, Dr. Vickrey says. Drugs don t seem to help. Several small studies suggested that the anticholinesterase drug pyridostigmine might be effective, but a 1999 placebo-controlled trial of 126 PPS patients found no benefit, says Dr. Trojan, the lead author. Patients should be encouraged to remain as active as possible, to stay fit, and control their weight, Dr. Dalakas advises.
Exercise is important.
For some, perhaps nothing more strenuous than stretching or yoga can be helpful. For others, swimming or more vigorous exercise, including aerobic workouts, might work. But patients must stop before fatigue sets in, he cautions. As a general rule , the progression of symptoms is fairly slow, and the overall prognosis is good. Physicians should reassure patients that PPS is not life-threatening and not necessarily disabling.