By the second trimester, many of the skeletal abnormalities can be noted on ultrasound. Currently, protocol involves the use of CVS followed by serial ultrasounds. Bone metabolism and bone mineral density in childhood hypophosphatasia. The Metabolic and Molecular Basis of Inherited Disease. Medicine is a constantly changing science and not all therapies are clearly established.
New research changes drug and treatment therapies daily.
However, as medical science is constantly changing and human error is always possible , the authors, editors, and publisher or any other party involved with the publication of this article do not warrant the information in this article is accurate or complete, nor are they responsible for omissions or errors in the article or for the results of using this information. The reader should confirm the information in this article from other sources prior to use. In particular, all drug doses, indications, and contraindications should be confirmed in the package insert. Hypophosphatasia Please email us with any comments you have on our new chapter format.