The studies proposed willconsider structural and functional MRI in conjunction with cognitive data so that multiple independent measures of brain integrity will be evaluated within the same individuals. The application of MRS and fMRI techniques provides new methods of collecting biochemical and metabolic information complementary to the anatomical results provided by MRI and the behavioral data evaluated by neuropsychological testing. The aims of these studies are to identify abnormalities in frontal or temporal lobe structure and activity or differences in cortical metabolism in patients with psychosis and to examine the association between frontal and temporal function as measured by neurocognitive tests and morphologic and metabolic findings measured by MR techniques. Brain Imaging Center, McLean Hospital. Project Director and Contact Person.
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Levin S, Yurgelun-Todd DA, Craft S. Contributions of Clinical Neuropsychology to the Study of Schizophrenia. An Echo-Planar Study. Patterns of Neuropsychological Deficits Discriminate Schizophrenics From Siblings and Controls. Schizophrenia Research, in press. H Spectroscopy of the Temporal Lobes of Schizophrenic and Bipolar Patients.