I am still playing with the dosage, but I am somewhat optimistic. It seems that both girls are not losing function as quickly as they were before. With this treatment, you want to start in the early stages of the deterioration to help prevent the loss of function. If you wait until your rat is barely moving it won't do much good. If you rat becomes completely paralyzed he is at increased risk for pneumonia, bladder infection, skin breakdown, and injury from cagemates.
Pneumonia becomes an increasing possibility with immobility.
The pooling of secretions in the lungs provides a great medium for bacterial growth, and, of course, our furry friends have enough respiratory problems as it is. Some rats will move around quite a bit after suffering paralysis of their hind legs. They just drag themselves around with their front legs like nothing is wrong. Some will be relatively immobile right from the beginning, and most will become sedentary at some time after losing the use of their back legs. My rat, Lancelot, became paralyzed at age two years and seven months.