Nitrogen dioxide can be detected below the permissible exposure limit by its odor and irritant effects and is regarded as a substance with adequate warning properties. Animal testing indicates that nitrogen dioxide does not have carcinogenic or reproductive effects. Cylinders of NO gas exposed to fire or intense heat may vent rapidly or explode. Reactivity and Incompatibility Nitrogen dioxide-nitrogen tetroxide is a powerful oxidizer and can cause many organic substances to ignite. This substance may react violently with alcohols, aldehydes, acetonitrile, DMSO, certain hydrocarbons, and chlorinated hydrocarbons.
Metals react vigorously and alkali metals ignite in NO .
In particular, cylinders of nitrogen dioxide should be stored and used in a continuously ventilated gas cabinet or fume hood. If large amounts of this compound are inhaled, the person should be moved to fresh air and medical attention should be sought at once. In the event of skin contact, immediately wash with soap and water and remove contaminated clothing. If nitrogen dioxide is ingested, obtain medical attention immediately. In the event of a release of nitrogen dioxide, use appropriate protective equipment and clothing.