The installation will warn you or notify you if you are attempting to install ISIS 2.1.2 onto a computer that does not meet the minimum hardware configuration. The following table describes the hardware configuration for successfully running ISIS and MDL ISIS applications. Open that volume. Install in a folder called ISIS 2.1.2. For brief operating instructions, see the instruction sheet link.
Online help is easy to use and extensive.
You can run it concurrently with the ISIS applications. If you and I are not able to figure out how to do a type of search or use a given feature, we have phone support from MDL available. Other databases are not free. The default is to search all the databases. You can choose a subset of the databases to search.