Eligible applicants must not possess more than five years of postdoctoral experience. In the cover letter, list the position title and the HNV number. Minorities, women, and handicapped individuals are encouraged to apply.
Positions are open until filled.
An Intramural Research Training Award position is available to study the molecular mechanism of xenobiotic-inducible transcription of cytochrome P450 gene. Candidates should have a Ph.D. and a strong background in molecular biology or related field. A putative phenobarbital-responsive enhancer element of the mouse Cyp2b10 gene is identified in the primary hepatocyte system. Purification of the nuclear factors that bind to the enhancer and a signal transduction pathway to regulate these factors will be studied. Study of the regulation of gene expression during differentiation and the mechanism of action of retinoids is being conducted.