Increases LDL clearance from the plasma. Weakly stimulate VLDL synthesis resulting in small increases in VLDL, HDL, and triglyceride. Flatulence, constipation, bloating, steatorrhea. Due to malabsorption of vitamin K. Gallstones. Supersaturation of cholesterol in bile may lead to increased incidence of gallstones and cholecystectomy.
Resins can slow the progression of atherosclerotic lesions.
The increase in triglycerides can be quite substantial in hypertriglyceridemic patients, and the resins should not be used in such individuals, or a triglyceride-lowering agent should be added to the regimen. Impairs absorption of certain drugs. Digitalis glycosides, thiazides, high ceiling diuretics, propranolol, clofibrate, hydrochlorothiazide, warfarin, tetracycline, vancomycin, thyroxine, iron salts, pravastatin, fluvastatin, folic acid, phenylbutazone, aspirin and ascorbic acid are affected. Reduces absorption of lipid-soluble drugs and vitamins because of reduction in bile acids. Miscellaneous Poor patient compliance.