My attention was particularly concentrated on immunoassays for measuring urinary excretion of PYD and DPD as markers for monitoring bone resorption. These parameters will be of main interest to me in my future professional work. I collagen of bone and is very specific measure of bone resorption. PYD is also found in type II collagen of cartilage, but because of the comparatively larger mass of bone collagen and the slower turnover rate of cartilage collagen, most PYD excreted in the urine originates in bone. Measurement of PYD and DPD is intended for use as an aid in monitoring bone resorption changes in postmenopausal women receiving hormonal or biphosphonate antiresorptive therapies and in individuals diagnosed with osteoporosis.
Osteoporosis is one of the main complications of the postmenopause.
For normalization of urinary pyridinolines urine creatinine was measured. Differences between pre-M women with and without use of OC were not significant. A postmenopausal HRT was able to lower excretion of both PYD and DPD significantly. In contrast, a preventive use of HRT in the perimenopausal age had no effect on urinary excretion of pyridines. The results from our study confirmed the utility of PYD and DPD measurement for identifying individuals with increased bone turnover and for monitoring bone resorption changes in postmenopausal women receiving hormone replacement therapy.