The answer is YES, it can make a big difference. Likewise, it is easily possible to not have enough light and encounter the above discomforts. Most Office buildings are comprised of florescent lights. This can be a huge problem, especially in the Summer months.
Florescent lights produce light from the Blue light spectrum.
The standard house light or incandescent bulb produces light from the red side of the light spectrum. The problem is that glare tends to increase when light is produced from the blue side of the spectrum. The general guidelines for lighting indicate that 1,000 lux is necessary for reading and 500-750 lux for computer work. Of course, we tend to complete both tasks throughout the day complicating matters. Solutions are often simple and inexpensive.