For example, if new routes for blood flow could be induced to develop in heart tissue damaged as a result of a heart attack, much of the suffering and devastation following a heart attack could be dramatically reduced. His research has not only proved the existence of angiogenesis as a biological phenomenon, but has also created a totally new therapeutic strategy to treat a variety of human diseases caused by unwanted blood vessel growth. Dr. Folkman has discovered molecules, such as endostatin, that block new vessel growth through a process called anti-angiogenesis. Folkman has discovered how endostatin impedes atherosclerosis in animals, paving the way for new revolutionary treatments for human cardiovascular disease. Anti-angiogenesis also has implications for the treatment of cancer, as these agents could cut off the blood supply and thus literally starve tumours.
Endothelial cells have many complex functions essential to health.
These functions can become deranged in a predictable way in diseases such as atherosclerosis. Mr. J. Allyn Taylor, one of the Founders of The John P. Robarts Research Institute and first Chair of its Board, is an Officer of The Order of Canada and a widely respected Canadian business leader named to the Canadian Business Hall of Fame. Mr. Taylor is an individual who, throughout his lifetime, has demonstrated a deep regard for, and a passionate involvement in health care matters. He was President of the London Health Association and Chair of the Board of University Hospital, now known as London Health Sciences Centre. He has also been Chancellor of The University of Western Ontario, Chair of the Board of Canada Trust, National President of the Canadian Chamber of Commerce, Chair of the Board of the McMichael Collection and Chair of the Ontario Press Council.