Intracellular events determine the fate of antithrombin Utah.
Inhibition of thrombin by hirudin genetically fused to wild-type or mutant antithrombin. Potent antithrombin activity and delayed clearance from the circulation characterize recombinant hirudin genetically fused to albumin. Impact of mutations at the P4 and P5 residues on the reaction of antithrombin with thrombin and elastase.