An increase in water content and amino sugar content were also noted. One injection per week was done for 6 weeks. In a different study by R.G. Klein in 1989 histologic documentation of ligament proliferation in human subjects in response to proliferative injections was demonstrated. Biopsy specimens of posterior sacroiliacligaments were performed pre- and posttreatment in three patients with low back pain. Each patient received a series of six weekly injections using the P25G solution into the sacroiliac ligaments.
Inflammation is the reaction of living tissues to all forms of injury.
It involves vascular, neurologic, humoral, and cellular responses at the site of injury. Increased vascular permeability is the first mechanism. It allows the escape of plasma proteins and white cells. This is known as exudation. The most important chemotactic factors for both neutrophils and macrophages include C5a, a compnent of the complement system, leukotriene B4, a product of arachidonic acid metabolism, and bacterial products.