Systemic elastorrhexis affecting skin, eyes, GI system, heart. Inherited either A.R. or A.D. Thought to be a result of accumulation of polyanions in dermis that attract calcium, which cause mineralization. Paget's Disease Connective tissue disorder involving collagen matrix of bone. Enlarged bone mass, extraskeletal calcifications of skin and arteries. Presence of angioid streaks associated with more severe systemic disease.
Incidence increases with age.
Other Systemic Associations Many-question coincidence. Calcified and brittle Bruch's membrane in PXE and Paget's. Various theories for sickle cell-elastic degeneration, iron deposition, impaired nutrition, small vessel occlusion. No contact sports. Low vision aids.