The improvement in insulin sensitivity resulted in regular menses as early as one month later. Because it is new, criteria need to be developed for its use. However, because oral contraceptives raise triglyceride levels, the results of concomitant troglitazone use are hard to predict. If exercise and dietary methods fail, many physicians recommend pretreatment with an GnRH agonist or oral contraceptive. Now, they also have the choice of troglitazone.
Questions remain about troglitazone's use to facilitate ovulation.
Although conversion of excess androgens to excess estrogens may suppress FSH, it is unknown to what extent troglitazone use would help. It may become a primary therapy to restore ovulation.