Qizhu Ding, Kelly Chichak and J. William Lown.
Marine organisms are a rich source for natural products.
Many of these compounds have generated interest both as challenging problems for structure elucidation and synthesis as well as for their cytotoxicities. The isolation, structure proof, biological activities, chemical properties and synthesis have attracted the attention of chemists, biologists and pharmacists. Of the makaluvamines, makaluvamine F and A are the most cytotoxic to the HCT 116 cell line. Both makaluvamine A and C can decrease tumor size in a solid human tumor model. Eilatin, as a 1,10-phenanthroline derivative, can form complexes with metal ions.