It is manufactured in the body when the simple sugar glucose combines through enzyme action with glutamine. The result of this action is then sulfated by other enzymes to form glucosamine. In this form it gives cartilage its strength, structure, and resiliency. One component of connective tissue is collagen, which holds water and gives connective tissue its flexibility. Proteoglycans are another component of connective tissue, and they are the basic substance of joint cartilage.
Glucosamine helps to form the proteoglycans found in the gelatinous ground substance of cartilage. .
None of those receiving the glucosamine had any detectable narrowing of their joint lining, while 106 of those receiving the placebo showed signs of joint narrowing. Those using the placebo said their knees felt slightly worse, while those receiving glucosamine reported their knees improving. 1500mg, Chondroitin Sulfate 1200mg, per 5 Capsules, recommended daily dose. The seeds are used, as the husk swells eight times its dry volume in water. It has also been used in traditional herbal systems of China and India to treat diarrhea, hemorrhoids, bladder problems, and high blood pressure.