Dystrophies of the cornea are not associated with previous infectious, systemic or inflammatory disease.
Mild cases are usually asymptomatic.
As the corneal guttata spreads from the center to the outer portions of the cornea, the patient may experience blurry vision. Pain is associated with bullae and loss of cells on the front surface of the cornea. Guttata are thickened areas caused by abnormal production of Descemet's collagen by endothelial cells. The cornea will start to swell. Folds may develop in Descemet's membrane.