Patients treated with the oral solution should be monitored for adverse effects of propylene glycol, which include seizures, stupor, tachycardia, hyperosmolarity, lactic acidosis, renal failure, and hemolysis. Patients taking the oral solution should change to the capsule form when able to do so, and they should avoid alcoholic beverages when taking the oral solution. There are no data on methadone interactions. APV increases sildenafil AUC by 2-11x. C. Rat teratogen test shows incomplete ossification, thymic elongation, and low birth weight.
Placental passage is unknown.
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