For example, we are working on using our understanding of regulatory proteins to design proteins to turn genes on and off at will. We have also been involved in the invention of the gene gun, a technique for introducing foreign genes into tissues of living animals. We have recently used the gene gun to demonstrate a new approach to vaccination we call genetic immunization, and we continue to work on its improvement. Our major interest is now in manipulating molecular recognition. We are working to design efficient methods for targeting genes to cells, modulating gene expression and improving viral delivery systems.
Genetic immunization is a simple method for eliciting an immune response.
Genetic evidence that an activation of GAL4 does not require acidity and may form a b-sheet. Yeast bleomycin hydrolase is a DNA-binding cysteine protease. A highly conserved ATPase protein as a mediator between acidic activation domains and the TATA-binding protein. Thyroid hormone and retinoid X receptors interact directly with a highly conserved transcriptional mediator.