If you continue to take d4T after nerve damage shows up, it may become permanent. Lactic acidosis is a buildup of lactic acid in the blood. This is a by-product of abnormal energy production by the cells. It may be caused by damage to the mitochondria. See Fact Sheet 554 for more information on mitochondrial toxicity .
Lactic acidosis can cause severe damage to the pancreas and liver.
Symptoms of lactic acidosis can include weight loss, abdominal pain, and severe fatigue. T is more effective if taken with other antiviral drugs. Pregnant women should not take d4T and ddI at the same time due to an increased risk of lactic acidosis. This document was provided by the New Mexico AIDS InfoNet .