After Frank consumes, among other things, a spoiled oyster, a rogue germ is unleashed upon the city of germs that lives within his body.
Osmosis is called into action to defeat the germ and save the digestive system.
The live action segment, which stars Bill Murray, Molly Shannon and Chris Elliot, recently completed a little over a week of filming in Plymouth, Massachusetts. As far as I know, the filming was a rarity for Plymouth. The only other feature film that came close to the town was The Witches of Eastwick , filmed to the north in Cohasset. After several attempts to contact the appropriate people to get some official information on the Osmosis Jones filming in the area and not getting a return phone call, combined with the fact that everyone I talked to wouldn't disclose the locations for filming, I figured I would head down there myself to see what I could find out. Production-wise this looked to be a very small, low key operation.