It took me a couple of days to get used to the feel of the mouse, but even during the acclimation period tracking and selection were easily manageable. I used the Graphire mouse when hosting an Internet conference the second day I had it, with no problems. It did take a little practice to get used to holding the pen near, but not touching the pad when moving to the menus, to keep from drawing TO the menus. As a photographer and not a paint artist, a graphics pen is a new tool to me. I use mouse mode for the mouse, and tablet mode for the pen.
Most settings are user selectable.
For example, the mouse scrolling wheel speed is customizable, the mouse button functions are programmable, the pen side buttons are programmable, and the pen sensitivity is changeable. Summary The Graphire pad, pen, and mouse have a different feel than the normal mouse, but everything is easy to learn and a pleasure to use. In fact, I liked the system so well that I'm buying the one I reviewed rather than returning it to Wacom after the review.