Intel Paragon parallel computers Cray T3D parallel computers MAST has been completely rewritten to provide more accurate p-values and to run significantly faster. A MAST server has been added to the MEME system website. The on-line documentation of MEME has been expanded and improved. The MEME server now runs MAST on your sequences to make it easy for you to see the ordering and spacing of the motifs MEME discovered. This greatly improves the sensitivity and selectivity of motifs using these types of models.
MAST now computes p-values for sequences when searching large databases.
This provides better discrimination between true and false positives than using z-scores. MAST is still only available via ftp, not via the web server. The scores from all motifs characterizing a family are combined, normalized for sequence length, and sorted by z-score. This provides better sensitivity and selectivity than single-sequence homology searches. MAST is currently only available in the ftp-able code, not via the web server.