The principle difference between the different cytochrome P-450 is the way in which the heme activates molecular oxygen. The reaction of arene oxides with glutathione generally results in detoxification. The structure below depicts the active S-alcohol metabolite. One major reason for the original synthesis of procaine was to generate a local anesthetic with a longer duration of action than procainamide. The metabolism of secondary alcohols in vivo generally involves oxidation to the corresponding ketones by alcohol dehydrogenases using NADH as the cofactor, followed by elimination of the ketone in the urine.
Glucuronic acid is biosynthesized from glutamic acid.
An error is made, and 75 l is injected. If the internal standard method is being used, the determination will still be valid. Therapeutic drug monitoring is typically more important for a drug with a low therapeutic index than for a drug with a high therapeutic index. Each of the following questions has one and only one correct answer. You are to circle the letter of the correct answer directly on the test.