In Depression Reboxetine has surfaced as being well tolerated and effective for the treatment of depression both in geriatric and younger adult patients. The drug might be particularly useful in restoring motivation, activity and social function early in the recovery phase.
Reboxetine seems to work by increasing noradrenergic availability.
We know that norepinephrine is involved in regulating energy, drive and motivation. Affective memory and fear conditioning are clearly involved. Reboxetine, a drug that has a selective noradrenergic effect, is the most selective drug available. It is a norepinephrine reuptake blocker, which interacts with a transporter and may have useful effects on age-related defects in norepinephrine function. There have been a few studies on the efficacy and safety of reboxetine on geriatric depression.