J Allergy Clin Immunol. Patients usually do not have a fever. Antibiotics are often helpful to relieve these increased symptoms. The choice of antibiotics for treatment of chronic sinusitis is controversial. There is no consensus as to which drug is most effective.
Most experts advocate treatment with antibiotics for a minimum of three weeks.
In some cases, even longer courses of antibiotics may be needed. Some experts recommend that antibiotics be continued for at least 1 week after the patient appears symptom free. The most common approach for corticosteroid adjunctive treatment is for patients to take prednisone for seven to ten days. Antibiotics are begun along with the prednisone and continued for 3-4 weeks. Several studies have shown that topical intranasal steroids help to reduce the size of nasal polyps and prevent their regrowth after sinus surgery.