Patient responses to treatment must be monitored and drug dosages modified accordingly. The antifungal drug ketoconazole reduces testosterone in boys with testotoxicosis. Testolactone, an inhibitor of aromatase, reduces serum estradiol and effectively treats girls with McCune-Albright syndrome. In most cases, hormone-producing tumors, specifically granulosa cell tumors in girls, should be excised. However, prolonged follow-up is necessary in case of recurrence in the contralateral ovary.
Excision is also an option for the various neoplasms causing pseudopuberty in males.
However, some of these tumors are aggressively malignant and associated with high mortality. A structural lateral curvature of the spine. Scoliosis may first be suspected when one shoulder seems higher than the other or when clothes do not hang straight, but is often detected on routine physical examination. An initial complaint may be fatigue in the lumbar region after prolonged sitting or standing. This may be followed by muscular backaches in areas of strain, such as the lumbosacral angle.