It sounds like you need a complete re-appraisal at an MS Care Center. There's an excellent one in your neighborhood run by Dr. Jack Burks. My MRI of the brain is negative. When serial MRI studies are performed every two weeks on MS patients, white spots come and go, sometimes without any noticeable symptoms. The diagnosis of MS rests on your history and examination.
Plaques can appear anywhere in the central nervous system that has white matter.
They are more likely to occur in the cerebrum around the ventricles but can certainly appear in the optic nerves, cerebellum, brainstem, and spinal cord. The signs and symptoms depend upon what part of the nervous system is involved and how severely it is involved. It is a smoldering forest fire that never extinguishes, even over decades. This material is provided as general medical information only and may not include all side effects or details relevant to a particular individual's treatment. Boards, Forums and Chat Questions by People with MS Answers by caring Neurologists.