Unlike podophyllin, podofilox is a pure compound with a stable shelf-life and does not need to be washed off. Heavily keratinized warts may not respond as well as those on moist mucosal surfaces. To apply the podofilox solution safely and effectively, the patient must be able to see and reach the warts easily. Podophyllin therapy is relatively inexpensive, simple to use, and safe. Compared with other available therapies, a larger number of treatments may be required.
Most patients experience mild to moderate pain or local irritation after treatment.
Heavily keratinized warts may not respond as well as those on moist mucosal surfaces. Few data on the efficacy of TCA are available. One study among women showed efficacy and frequency of patient discomfort to be similar to podophyllin. No data on the efficacy of bichloroacetic acid are available. Few data on the efficacy of electrodesiccation are available.