Vaginal stenosis and penile scarring have been reported. Renal complications are rare. A Caucasian predominance has been reported. Typically, the disease process begins with a nonspecific upper respiratory tract infection. Vomiting and diarrhea occasionally are noted as part of the prodrome.
Mucocutaneous lesions develop abruptly.
Clusters of outbreaks last from 2-4 weeks. The lesions typically are nonpruritic. Patients with genitourinary involvement may complain of dysuria or an inability to void. A history of a previous outbreak of SJS or of erythema multiforme may be elicited. Recurrences may occur if the responsible agent is not eliminated or if the patient is reexposed.