Best results are expected with prolonged retention. Response to treatment and adjustment in dosing frequency should be determined by periodic examination, including endoscopy and the assessment of symptomatology including rectal bleeding, stool frequency, and general well-being. Daily dosing is continued until a significant response is achieved or the patient achieves remission. Abrupt discontinuance of 5-ASA is not recommended. Dose tapering is recommended and each patient should be titrated to meet individual needs.
Maintenance therapy is recommended to assure continued remission.
If symptoms, diarrhea and rectal bleeding, recur, dosage should be increased to the previous effective level. Two 250 mg or one 500 mg suppository is self-administered on a daily b.i.d. or t.i.d. basis. Dose tapering is recommended. Abrupt discontinuance is not recommended. Best results are expected with prolonged retention.