I won't bother to show the data for toxin A or protease, but will state that there was no pattern for these enzymes which could be correlated to mouse virulence. Although exoenzyme S shows the best correlation to mouse virulence, it is obvious that virulence in Pseudomonas aeruginosa is multi-factorial and that no single cellular function measured to date can account for pathogenicity. I would like to take this opportunity to thank the contractors, Drs Wood, Lam, Speert and Paranchych for their efforts. A special thanks goes to Maureen Campbell at the University of British Columbia for maintaining the strain collection and identification verification of the strains used. Mouse lethality and cytotoxicity of Pseudomonas aeruginosa strains.
Lower numbers indicate greater toxicity.
Mouse lethality and toxin A of Pseudomonas aeruginosa strains. A activity was measured as the counts from precipitates incorporating radiolabelled NAD with wheat germ extract as the substrate. Incorporation was allowed for 30 min. Pseudomonas aeruginosa Figure 3. Mouse lethality and elastase of Pseudomonas aeruginosa strains.