The researchers predicted CHD risk by relating findings in clinical studies to epidemiological studies. Numerous clinical studies have examined alcohol's effect on certain lipids and blood clotting factors. Though epidemiological studies have provided information about associations between these factors and CHD risk, only a few have looked at this relationship specifically. They then estimated the CHD risk associated with these changes based on epidemiological studies that related these biomarkers to disease risk. New Angiogenesis Inhibitor Identified Adding to the arsenal of potential anticancer agents, researchers at Massachusetts General Hospital report the discovery of a new inhibitor of angiogenesis and tumor growth.
Mice missing the gene have significantly more blood vessels throughout their bodies.
They inserted the gene into human squamous cancer cells and then injected these cells into the skin of mice. As expected, mice injected with cancerous cells containing neither gene rapidly developed tumors. Interestingly, tumor formation was completely inhibited in cells expressing both genes. In their paper in the Dec. 21 Proceedings of the National Academy of Sciences , the researchers state that combination therapies such as these, just like combined angiostatin and endostatin therapy, may be more effective than the use of single agents. Many studies have reported immune system imbalances in these traumas, which likely play a key role in susceptibility.