NO synthase isozymes have distinct substrate binding sites. Calmodulin response is complete within the reductase domain itself. EPR spectroscopic characterization of neuronal NO synthase. Binding of ligands at the arginine site induces changes in the heme ligation geometry. Heme iron reduction and catalysis by a nitric oxide synthase heterodimer containing one reductase and two oxygenase domains.
Electron transfer occurs between flavin and heme groups located on adjacent subunits in the dimer.
Spectral characterization of brain and macrophage nitric oxide synthases. Interactions between substrate analogues and heme ligands in nitric oxide synthase. Direct measurement of nitric oxide generation from nitric oxide synthase. I with isocyanides. A multinuclear NMR study.