It is usually observed in males in the fifth to eighth decades of life.
Most lesions occur on the vermilion border of the lip following a prolonged period of sun exposure.
Squamous cell carcinoma begins as a recurring ulceration and encrustation. Eventually, this non-healing ulcer develops a rolled border that is indurated. This benign lesion has a clinical appearance, rapid growth, and microscopic features similar to squamous cell carcinoma. However, this lesion usually undergoes spontaneous regression without any type of treatment. This neoplasm is found in males more often than females.