A member of the trithorax gene family which are implicated in the control of transcription, chromosome structure, development, and human leukemia. The SET or Tromo domain is a 130-140 amino acid motif shared by some family members.
Mutants are defective in transcriptional silencing of the silent mating-type loci and telomeres.
The SET1 domain interacts with Mec3p, influences MEC3 function in DNA repair, telomere position effect, and perhaps in telomere length maintenance. Corda et al. The telomere protein database is a developing prototype. We welcome your suggestions or comments .