The severity of symptoms can vary with this disease, and the severe forms become apparent early on. Bleeding is the hallmark of the disease and typically occurs if an infant is circumcised. Additional bleeding manifestations make their appearance when the infant becomes mobile. Mild cases may go unnoticed until later in life when try occur in response to surgery or trauma. Internal bleeding may happen anywhere, and bleeding into joints is common.
Risk factors are a family history of bleeding and being male.
The incidence of hemophilia A is 1 out of 10,000 men. Once the defect has been identified, other family members will need less testing to diagnose the disorder. Standard treatment is infusion of factor VIII concentrates to replace the defective clotting factor. The amount infused depends upon the severity of bleeding , the site of the bleeding, and the size of the patient. To prevent a bleeding crisis, people with hemophilia and their families can be taught to administer factor VIII concentrates at home at the first signs of bleeding.