Make sure that those you hire to lead technological changes are competent, and that you are clear as to what you want them to accomplish. Set up contingency plans to fall back on. Plan for upgrades and for your staff's outgrowing the technologies they have. Know that change is a painful process and be ready for the bumps in the road to success. Good communication is essential in the process.
People come before technology.
Take a step back from things every once in a while to view the overall picture. Don't take yourself too seriously. Know when to say when. Don't expect others to become responsible for things they have no way of delivering. Don't promise what you can't deliver.