Avoid use in patients suffering from alcoholism as they are at increased risk of hepatotoxicity. Use with caution in patients who are hypersensitive to opioids other than oxycodone. Use with caution in patients with respiratory depression or respiratory disease. Oxycodone combined with an MAOI may result in a severe hypertensive reaction. If this is not possible, use with caution.
Naloxone reverses the effects of oxycodone.
Sulfinpyrazone may increase the risk of acetaminophen hepatotoxicity particularly when acetaminophen is used at high doses. Acetaminophen may augment the effects of warfarin, although this is associated with prolonged use of acetaminophen at high doses. Avoid abrupt discontinuation of codeine following prolonged use, as physiologic dependence may have developed.