Frequence answers range from 0 to 1. There are many different antibiotics that one could chose. Based on the two mutation frequencies, class 1 mutations most likely effect the transport function. Based on the two mutation frequencies, class 2 most mutations most likely effect the polymerase. Any mutation that knocks out transport of compound X from outside the cell to the inside of the cell will lead to resistance.
Many different mutations can occur to eliminate the activity of the transporter.
Mutations that affect the ability of RNA polymerase to interact with compound X will also lead to resistance. However, for the cell to be viable, it needs RNA polymerase activity. Thus only a few mutations will prevent the interaction of RNA polymerase with compound X but still allow RNA polymerase to function in transcription. The target for class 1 mutations is larger than the target for class 2 mutations. Draw a line under each codon from the open reading frame, and write the corresponding mRNA sequence for the open reading frame.