By now the adaptation of the assays for chicken is completed. Immunopathogenesis and immunomodulation of various diseases in cattle, horses and companion animals, including tumourimmunology Tumourimmunology. Furthermore a possible role of inherited factors in tumour-bearers was investigated by studying DNA repair capacity of cells in vitro after UV irradiation. In the Netherlands IL-2 therapy of horses bearing sarcoid tumors is still executed. Immunopathogenesis of bovine paratuberculosis.
Results show that infected macrophages have clearly decreased antigen-presenting capacity.
Efforts to set up a rat model for paratuberculosis failed thus far. During this second year of the study the M. paratuberculosis Hsp 70 was cloned and expressed. Together with researchers in Germany, Spain and the UK an EU proposal is underway. For slightly more than a year the graduate student Sinke joined our lab to intensify the research in this field. After studying histology of lesional tissues, functional lymphocyte studies were performed.