Protein folding is an increasingly important field in bio-medical research.
The data base of point mutations which cause disease is expanding daily. It is also clear that protein mis-folding is the basis for a number of diseases, such as Altzheimers and prion diseases. Considerable progress has been made in understanding in detail the folding of a few model proteins. We are now extending this work to look at the folding of protein families, in particular families of proteins with biological or medical significance. Our work benefits greatly from collaborations with colleagues working in the fields of bioinfomatics, structural biology and clinical genetics.