I shudder to think of the fate of those not ready, willing or able to join their glittery, sinister utopia. The transhumanists might or might not be psychologically pathological, but they are undoubtedly afflicted with a spiritual pathology. In short, they idolize means at the expense of ends. Nothing could be more dangerous than technology without morality, unlimited means ungoverned by ethical ends. The answer to their question is that means should serve ends, and not become ends in themselves.
Nothing can be good unless it serves a truly good end.
No objective standard of value is possible unless it is grounded in nature, i.e. in objective reality. Man, at his best, is quite good enough. The problem is to enable the whole human race to live up to the potential inherent in human nature. This is the goal set by nature. Eugenics, despite all its excesses and abuses under the Nazi regime, was benign compared to transhumanism.