This project will involved an analysis of the Drosophila genome in search of genes involved in the non cleavable function of Notch. The screen will be make use of deficiencie kits that are available for much of the genome and will lead to the identification of regions containing genes involved in this function. These regions should identify genes which are involved in the dominant effects of the receptor and which act downstream of it. A pilot experiment on a small number of candidate genes suggests that the approach will be effective. Science 284, 770-776.
Notch is required for wingless signalling in the epidermis of Drosophila .
Cell 79, 259-272. A functional analysis of Notch mutations in Drosophila. Genetics 147, 177-188 4. Repression by Notch is required before Wingless signalling during muscle progenitor cell development in Drosophila . Current Biology 9, 707-710. 5.