In most cases, disease is transmitted via bite wound. The virus attaches to the local muscle cells for a couple of days before penetrating to local nerves and beginning its slow ascent to the brain. Virus ultimately reaches the brain and in two to three days more is evident in all body secretions including the saliva. At this point, the disease becomes transmissible and symptoms begin. A change in personality is noted.
Friendly animals become shy etc.
The animal has no fear and suffers from hallucinations. It is from animals in this stage where most human exposure occurs. There is no treatment for animals or humans once clinical signs appear. The reservoir for this virus consists of wildlife species. Humans and domestic animals are not generally exposed unless conditions promoting contact with wildlife occur.