One may see a penny or other radio dense object of about the right size on a radiograph or there may be a known history of penny eating. It is important to rule out immune-mediated hemolysis as this is a common condition requiring specific treatment. How zinc is able to produce hemolysis is not known. If an object possibly made of zinc is seen on a radiograph, it should be removed promptly. Support then becomes crucial.
Fluid therapy is important to keep circulation to the kidneys adequate and help prevent failure.
Transfusion may be necessary to combat anemia and anti-nauseal therapy is warranted. Research is looking at methods for binding excess zinc in the circulation similar to the way lead poisoning is treated. Many veterinarians are unaware of this special syndrome and do not realize that pennies far more than a simple foreign body. This is a very recently described disease and many questions are still unanswered.