Abstract 321, Vol.
Organic solvents alter the stratum corneum structure and barrier function.
Corneoxenometry entails collection of human stratum corneum by cyanoacrylate. The material is immersed in organic solvents for periods ranging from 1 to 120 min. After staining the samples with a toluidine blue-basic fuchsin solution, the color is measured using reflectance colorimetry. Solvent aggressivity to the stratum corneum correlates with the color darkening of the samples. The influence of contact time between solvents and the stratum corneum showed a logarithmic pattern which varied according to the solvent.