We are using a molecular biological approach in cell lines and transgenic animals. In addition, disorders of receptors are being investigated in neurological diseases and prostate cancer. A multi-disciplinary program of research into determinants of growth and development, and osteoporosis risk, involving female twins over a wide age range. Includes physiology, biochemistry, nutrition, epidemiology and biostatistics, genetics, and molecular biology. Of particular interest are studies of the role of specific genes as determinants of bone mass.
Mechanical loading is an important physiological stimulus to net bone formation.
This project is directed at improving understanding of the effects of mechanical loading on bone, using clinical and basic research approaches. Research topics encompass human movement, physiotherapy, physiology, and cellular and molecular biology. In this ongoing program, the pathogenesis, prevention and treatment of various forms of osteoporosis are under investigation. Suitable research topics include the effects of hormones and other factors on bone turnover and bone mass, and on the ultrastructure and histomophometry of sheep bone. The complication of bleeding from these ulcers is a major health problem, especially as aspirin usage to prevent heart attacks and strokes is increasing.