I really want to talk about that, because Barry works only in equilibrium. You heard what I thought of that. There are at the present time models that have successfully predicted a priori effects of molecular changes. No - only the ones that fit under that class of models. No - that's a deeper level of description.
Predictive models exist now, a priori .
They are successful, and that depends on the degree of comprehensiveness that you want and the degree of detail that you to be able to predict from. What's made modeling so successful in the electronics world is some thinking about framework. The Boeing 777 is not modeled at the atomic or molecular level - it doesn't need to be. So part of this is defining the question we want to answer, and another part is intelligently lumping parts of the system together, and that requires a framework - a framework that can span from the molecule to the organism, or even the society. But the model is able to take pieces that are developed along the way and integrate them fairly seamlessly.