Picture frames can be grabbed easily and with a minimum investment from the local craft store or photo shop. Perfect for pictures of their friends. Get 5x7's or ones that will hold school photos. A bottle of semi-expensive wine is often a good gift and doesn't even need wrapping in most cases. If you know the person prefers a certain type of alcohol, you can purchase that.
Food is always a hit.
Something elegant like smoked salmon or caviar is perfect for the boss, or a gift bag full of assorted favorites like chocolate and mints and Ju-Jubees for a closer friend works well. A subscription to a favorite magazine is a very quick and easy gift. You can usually find out from a spouse what magazine would be best and even get a subscription card from them. For anyone who loves movies, a movie guide is perfect. You can find them at your local bookstore.