How this event may affect meningioma growth is unknown at present. The MN1 protein has two domains that can activate transcription. The MN1-TEL protein can transform NIH3T3 cells, probably through a combination of the TEL DNA binding domain and the MN1 transactivating domains. MN1 by itself can also activate transcription, either by binding to DNA itself or by working as a coactivator. We have generated Mn1 knockout mice.
Homozygous mice die shortly after birth.
Human bladder tumors were studied with microsatellite markers for chromosome 9q. We obtained evidence for the presence of two putative tumor suppressor loci on this chromosome arm. We studied the possible involvement of chromosome 9p and the CDKN2A gene in uveal melanomas. CDKN2A. This suggests that in contrast to cutaneous melanoma this gene plays a minor role in uveal melanoma. There is increasing evidence that loss of chromosome 3q is an important early event in this tumor.