Dogs usually are otherwise healthy, but may show peripheral Lymphadenopathy, pyrexia, anorexia, or depression. Signs may wax and wane. These signs are non-specific. A response usually is evident in 1 to 4 weeks. The drug is not licensed for use in dogs.
Prognosis is guarded.
The term necrolytic migratory erythema refers to the skin rash occurring in humans associated with a glucagon-secreting pancreatic tumor or hepatic cirrhosis. In veterinary medicine, hepatocutaneous syndrome, superficial necrolytic dermatitis , and diabetic dermatopathy refer to the same condition. Skin lesions occur due to degeneration of keratinocytes, which results in epidermal edema and degeneration. The exact mechanism is unknown. Data regarding glucagon levels in veterinary patients is limited, and the role of glucagon in this disease in dogs is unknown.