A biopsy was performed. Discussion Pseudomembranous colitis due to Clostridium difficile was ruled out by the absence of pseudomembranes and negative Clostridium difficile toxin. The term typhlitis refers to intestinal ulceration in the presence of profound neutropenia caused by chemotherapy regimen. The lesions are usually in the right colon and may lead to septicemia, perforation, and bleeding. CMV and herpes simplex colitis were ruled out by the absence of viral changes in the biopsy and negative serology.
Ischemic colitis is usually a localized process rather than a diffuse one.
The biopsy did not show any evidence of ischemic changes. Each can occur as an isolated entity or in combination. The extent of organ involvement is shown in Figure 8.