Sporadic Gastric Cancer Yustein, A.S., J.C. Harper, G.R. Petroni, O.W. Cummings, C.A. Moskaluk, and S.M. Powell, Allelotype of gastric adenocarcinoma. Cancer Res, 1999.
Gastric adenocarcinoma is a leading cause of cancer mortality world- wide.
Yet, the underlying molecular events important in the development of this cancer are largely undefined. Thus, we performed a comprehensive survey for allelic loss on our panel of xenografted human gastric carcinomas. Contaminating normal stromal cells of primary cancers often limit mutational analyses. Xenografted samples of our gastric carcinomas provided optimally enriched tumors for neoplasia that clearly and sensitively demonstrated genetic alterations. Additionally, total absence of allelic signals in these xenografted samples confirmed true loss of alleles rather than just allelic imbalance.