These patients had each previously failed a mean of 2.7 chemotherapy regimens. Furthermore, some of the responses occurred in the face of bulky disease. Toxicity was minimal. The ability to spare normal tissue and the resulting toxicity is particularly important in this generally elderly population. One can link diagnostic or therapeutic radioisotopes to mAbs.
Prostate cancer is a relatively radiosensitive target.
Individual tumor sites tend to be small volume sites, ideally suited for both antibody delivery and access, as well as for beta-particle cytotoxicity. Given the theoretical advantages of mAbs in this disease, it is compelling to evaluate this approach.