5-HTP should not be taken with other antidepressants, MAO inhibitors, weight loss products, St. Vitamin B6 should not be taken at the same time, although it is helpful if taken about 6 hours earlier than the 5-HTP . However, this might be in error. They have not had any reports of EMS associated with it, though. Those with AIDS , cancer , autoimmune diseases and the very elderly have an increased risk of fibrosis because of an enzyme that is frequently elevated in these conditions.
Fibrosis is the deposition of connective tissue in internal organs.
5-HTP along with chronic alcoholism and liver disease caused heart fibrosis in animals. Alcohol inhibits the metabolism of 5-HTP . 5-HTP can increase the effect of tranquilizing drugs and can impair the ability to drive an automobile. In other words, it is not an absolute contraindication. Physicians sometimes use substances which have an interaction to accentuate the effect.