These are the physicists and the clergy, those who quest for the Truths beyond the scope of humanity. Well, I shouldn't say beyond the scope of humanity - many of the truths these people search for deal with humanity and their place in the world, what it means to be human and what it means to live in this world. And then there are those that no longer search, who have become mired in the pursuits of their day to day life. This is not necessarily out of choice. Indeed, people have really only recently had the option of concerning a decent period of their lives with non-mundane activity.
Many people still spend their entire lives, nearly all of their time, just working to get by.
But this is not exactly what I am referring to - I am referring to an attitude. Many of the people I know who have lost their bliss are quite well off enough not to spend every waking hour in the pursuit of subsistence. They have lost that very drive that defines us as human, whether it be in their own possessions or in the quick fix of a drug. Not that I am necessarily saying that money or drugs are bad. It is merely the love of these substances, the infusion of them with artificial meaning to the exclusion of all else that robs these individuals of their drive, robs these individuals of their humanity.