There is no sex predisposition. Laboratory findings are also variable, reflecting the primary disease, GN or renal failure. The CBC may be normal or disclose inflammation or anemia of chronic inflammation or renal disease . Urinalysis may show proteinuria , isosthenuria, or rarely hematuria. GN may progress to renal failure in some animals.
Renal failure is characterized by azotemia and isostenuria.
During the evolution of GN to azotemic renal failure, some animals will be proteinuric and azotemic but still have a concentrated urine specific gravity. As GN progresses further the animal will become isosthenuric as well. As GFR decreases markedly less protein is filtered and subsequently proteinuria is less severe. A syndrome is a group of clinical signs. Albumin is a small molecule so is readily lost in the urine of patients with glomerular damage resulting in reduced oncotic pressure and the development of edema.