Systemic therapy In severe cases, retinoids, methotrexate, cyclosporine, and hydroxyurea may be used. Systemic corticosteroids are generally ineffective, and they can exacerbate the disease. Management of ocular complications Ocular lubricants and punctal occlusion can be used to treat keratoconjunctivitis sicca. Trichiasis and cicatricial ectropion usually require surgical treatment. Topical corticosteroids are useful in treating the conjunctival, corneal, and anterior chamber inflammation.
Oral corticosteroids are occasionally necessary.
It is not clear whether systemic immunosuppression is effective for ocular disease. A bandage contact lens may retard the melting. Topical corticosteroids can control the infiltration and delay the vascularization. In some cases, progression can occur in spite of these treatments and can lead to the need for lamellar or penetrating keratoplasty. Modify the body's immune response to diverse stimuli.