Grafts were T cell-depleted using counterflow centrifugation. Donors were HLA-identical siblings. Outcome did not differ significantly between the two age groups. TRM was within the range of that reported in the literature for recipients of T cell-depleted grafts. For this age group of patients, results of nonmyeloablative regimens should be compared with that obtained with T cell-depleted grafts.
Hypersensitivity reactions are relevant adverse effects of asparaginase therapy.
Activity was determined every third or fourth day until it dropped below the limit of quantification. Comparable pharmacokinetic treatment intensity was achieved in about two-thirds of patients. No abstract available. No abstract available. Groupo Espanol de Trasplante de Medula Osea en Ninos.