In life something is what people think about.
People worry about details or they worry about the big picture.
The little nothings that trouble people only for a single moment of a single day are quickly forgotten. Rather its a place to hide at work or a bad day with a coworker little nothings are soon forgotten. Seinfeld takes those little nothings and combines them to create something which is truly something. From a logical perspective nothing is a mathematical impossibility. You never truly have 0 percent of anything, as you always have a small fraction of all other things by the inherant nature of matter and the atom.