Although the eruption is intensely pruritic, excoriations rarely are found. Routine biopsy specimens usually reveal a normal epidermis, but focal spongiosis and parakeratosis may be seen. Within the papillary and mid dermis, a lymphohistiocytic infiltrate with a variable number of eosinophils and dermal edema is present. Morbidity is not increased for the fetus born to an affected mother. Occasionally, systemic corticosteroids are required to alleviate severe symptoms.
Oral antihistamines are only mildly effective.
In addition, these agents modify the body's immune response to diverse stimuli. Use systemic steroids for severe, refractory cases only. Interactions None reported Pregnancy C - Safety for use during pregnancy has not been established. Antihistamines - Sedative effect may improve sleep. Continue symptomatic care until resolution.