This location can vary among individuals. Normally, the appendix fills with food and empties in conjunction with the main cecum on a regular basis.
Inflammation occurs when the patent lumen between the appendix and the cecum becomes obstructed.
When appendiceal obstruction occurs, the mucosa of the obstructed appendix continues to secrete fluids, causing a distended lumen and increased pressure exceeding that of the venous system. This leads to tissue ischemia and ultimately necrosis.