Anything less than mastectomy for Paget's should be considered quasi-investigational. Specimen demonstrates an area of healing biopsy cavity with granulation-type tissue and focal foreign body reaction with multinucleate giant cells. Throughout multiple sections there are focal areas of intraductal hyperplasia with rare areas of dystrophic calcification. One small intraductal papilloma is also identified. First sentence is what one would expect from re-operating on a healing wound, i.e., granulation type tissue, et cetera.
Giant cells are related to inflammation and healing.
Intraductal hyperplasia is a form of abnormal tissue formation that is benign. Dystrophic calcification is a fancy way of saying calcium deposit that is benign in origin. Intraductal papilloma is a benign breast tumor, probably found as an incidental finding in the tissue removed. The treatment for Paget's disease has traditionally been mastectomy, even if it's been entirely non-invasive. Patients who have Paget's should be aware of this.