Know the regulation of cholesterol biosynthesis 4. Know the pharmacological inhibitors of cholesterol biosynthesis 5. Know how bile salts are synthesized 6. HMG-CoA synthase for cholesterol biosynthesis is in the cytoplasm. HMG-CoA synthase for ketone body synthesis is in the mitochondrial matrix.
Product is mevalonate.
As the products of this pathway become more hydrophobic, the reactions are occurring in the ER B. Regulation of cholesterol biosynthesis 1. Cholesterol can affect levels of HMG-CoA reductase via inhibition of transcription of its gene, via increased proteolysis of existing enzyme, and via inhibition of translation of existing mRNA for the enzyme C. Pharmacological inhibitors of cholesterol biosynthesis 1. Biosynthesis of bile salts A. Made in the liver from cholesterol. B. Committed step is 7a-hydroxylase. This is a cytochrome P-450 enzyme.