No fissures or other types of damage were observed. Reed speculated that this was due to production of a growth inhibiting substance that increased the number of constrictions of each hair, causing a waved hair to be produced. Chimeras were generated from fusion of embryos using nine different recessive homozygous mutations, including wa2. Hairs from a mixed patch revealed chimerism within as well as between hairs for both pigmentation and waving. Pigmented and non-pigmented areas were evident along the length of the hair shaft.
Ocular lesions occur in many inbred strains of laboratory mice.
No analogous human disease has been compared to the waved-2 mouse mutant. Two null mutations of the Tgfa gene were created independently. The biology of EGF and its receptor can now be investigated when panels of mouse mutations with known or presumed abnormalities are used. By scanning electron microscopy the serpentine pattern is prominent. A new eye abnormality in the house mouse.