10.6 Internal Radiation Monitoring When handling unsealed sources of radioactive material, the potential always exists for introduction of the materials into the body.
Internal deposition can result from inhalation, ingestion or absorption.
Bioassay is required of individuals working with quantities and types of radioactive materials where significant internal deposition may occur. Bioassay is defined as the determination of the kind, quantity or concentration and location of radioactive material in the human body. When a potential authorized user is being evaluated for permission to use radioactive materials, the need for bioassay will be reviewed by the Radiation Safety Officer during his or her initial review of the application. When established authorized users wish to change a research protocol, increase significantly the quantity of radioactive material used in a procedure, etc., the possible need for bioassay should be discussed with the Radiation Safety Officer. 10.6.1 Hydrogen-3 Compounds.