As applied to life, perhaps the maxim cautions us to avoid getting into ruts and doing things the same way every time. Prepositions are not words to end sentences with. Of course they aren't. Prepositions are meant to show relationships. A sentence ending with a preposition looks and sounds unfinished, incomplete.
Relationships are important.
Avoid cliches like the plague. This goes without saying. Be an original. Employ the vernacular. Say what you mean and say it clearly.