Previous studies suggest that the nitrogen transport protein Npr1p acts antagonistically to Cac3p. CAC 3 overexpression strains exhibit the same phenotype as npr1 deletion mutants, suggesting that Cac3p binds Npr1p to inactivate the latter protein. We asked whether this interaction might also inhibit Cac3p, disrupting nucleosome assembly as measured by decreased silencing of telomeric inserts. Data will be presented comparing the phenotypes of NPR1 overexpression and cac3 deletion mutants strains. A knot is more than just a tangle in your shoelace or Christmas lights.
Knots are actually abstract mathematical objects that have many different scientific applications.
One such application is the topology of DNA molecules. Scientists have discovered that DNA molecules sometimes have knots in them. The velocity of DNA molecules travelling through gel depends on topological knot type. In this project, we replicate the movement of DNA through gel by sending physical models of knots through liquid and gaseous media. We then determine which mathematical invariants of the knots are correlated with velocity, therefore determining the knots that travel fastest in the process of DNA gel electrophoresis.