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Nabumetone is used to treat arthritis .
1 Animal models of inflammation have found that the copper chelate of aspirin was active at one-eighth the effective amount of aspirin. These copper complexes are less toxic than the parent compounds, as well. 2 Iron supplements can cause GI irritation. If both iron and nabumetone are prescribed, they should be taken with food to reduce GI irritation and bleeding risk. Sodium Nabumetone may cause sodium and water retention .