Computer Keyboard Wrist Rests Contact allergy to computer keyboard wrist rests is generally an allergy to a thiuram accelerator used in manufacture of the synthetic neoprene rubber. Most allergic contact dermatitis becomes evident 48 hours after contact with the offending allergen. Contact urticaria syndrome is an exception to this rule. Manifestations include immediate burning, itching, swelling or vesiculation. The reaction commonly occurs within minutes of exposure.
Implicated allergens are generally proteins.
This patient experienced immediate vesiculation when contacting proteins in raw fish. Raw Fish Reaction Immediate reaction to epicutaneous patch test with raw fish. Cooking denatures the implicated proteins, therefore cooked fish did not evoke a reaction. Severe reactions may be associated with symptoms of anaphylaxis. Anaphylaxis may occur during testing, and the physician should be prepared to treat anaphylactic reactions.