Patients often complain first of impaired central acuity in one eye. Eventually, the fellow eye usually becomes involved. Acute white lesions and old, healed atrophic lesions may be present simultaneously. Peripapillary atrophy or scarring and linear atrophic and hypertrophic streaks at the equator may also be present. Hyperplasia of the RPE may cause an enlargement of the chorioretinal scars and subretinal fibrosis.
Inactive lesions have a punched-out appearance.
The fundus findings in MFC can be very similar to those of presumed ocular histoplasmosis syndrome. Fluorescein angiography may show staining or leakage of the acute lesions. Laser may be effective for extrafoveal choroidal neovascularization, though many membranes spontaneously heal. This condition has a propensity for recurrences. Tell the patient to report back if any of the symptoms recur.