There was the thought that the cyanide in laetrile destroyed cancer cells. Research does not support this use. Products on the market have been shown to contain, calcium gluconate, glycine and dichloroacetate. Dichloroacetae is the only component shown to have pharmacological activity. There is no evidence that pangamate has any therapeutic benefit.
Orotic acid is an intermediate in pyrimidine metabolism.
Orotic acid is not recognized as a vitamin and may even increase hepatic lipids. Vitamin H3 has been promoted as a nutritional substance that decreases the symptoms of diseases related to aging. There is no sound research to support this claim. This compound is not recognized as a vitamin. Vitamin U is the methylsulfonium salt of methionine.