They also rebut some of the oft-made claims of creationism adherents, even when they're not discussing scientific principles per se. For instance, it has been commonly asserted that Charles Darwin renounced his theory on his deathbed. This turns out to be a baldfaced lie, introduced by a former servant who hadn't been anywhere near Darwin's deathbed, according to his widow. He explains that one of the reasons creationist arguments appear so powerful is because so many people have a misunderstanding about evolution. Evolution has never been observed.
Evolution violates the second law of thermodynamics.
There are no transitional fossils. The theory of evolution says that life originated, and evolution proceeds, by random chance. There are certainly many more, but these are among the most pervasive, so Isaak gives a thoughtful, reasoned explanation of how evolution has been observed, how it doesn't violate the second law, and so on. These are challenges to the creationist theory that the adherents never seem to address. Both consist of a set of questions for creationism adherents.