Allopurinol should be withdrawn immediately should such reaction occur. If the rash recurs, allopurinol should be permanently withdrawn. If they do occur, it may be at any time during treatment. Allopurinol should be withdrawn immediately and permanently. Corticosteroids may be beneficial in overcoming such reactions.
Gastrointestinal disorders diminish if allopurinol is taken after meals.
Overdosage of allopurinol is usually manifested by nausea and vomiting. Massive overdosing or acute poisoning by allopurinol has not been reported. There is no specific antidote for allopurinol. There has been no clinical experience in the management of a patient who has taken massive amounts of allopurinol. In patients with reduced renal function the dosage of allopurinol for injection must be reduced.