However, permanent injury and a clinically persistent sialadenitis is not an unexpected result. Propylthiouracil therapy for hyperthyroidism prevents the organification of iodine for thyroid hormone synthesis. The resulting elevated serum iodide is actively secreted by the salivary glands. A work hypertrophy with enlarged parotids can develop. These hormones decrease lower esophageal sphincter contractility.
Gastric reflux occurs.
Effective clearance of the acids is a protective function of the esophagosalivary reflex mediated thru the vague. Sialorrhea results and serves to neutralize the acids, ravage the esophageal wall and discourage esophageal disease. Since the diversity of these salivary conditions presents challenges to the clinician, the SGC is available for referrals.