I have also heard that breast tenderness is a sign of too much estrogen. When first starting or resuming estrogen therapy, the breasts can be sensitive and hurt. After about one or at the most two months, the breasts usually accommodate and the pain goes away. If it doesn't after 2 months, then the estrogen needs to be decreased. This is similar to how breast tenderness is worse in the early stages of pregnancy and then usually they get better over time.
Pregnancy has whopping doses of estrogen.
However, the more I read, the more confused I get. I continue to have hot flushes each morning prior to taking 1 Estratab with 1 Estratest. I am also experiencing a slight burning sensation in the outer upper quadrant of my breasts. After taking the meds, the symptoms disappear. It has to do with the half life of the medications in your body.