A CMV by immunofluorescence may be positive. A monospot test may be negative in CMV mononucleosis . A CBC shows decreased platelet count and atypical lymphocytes. A chemistry panel shows abnormal liver enzyme results. Treatment Return to top Most patients recover within 4 to 6 weeks without medication.
Rest is needed, sometimes for a month or longer to regain full activity levels.
Relief of symptoms is provided with analgesics , and warm salt water gargles for sore throat . Prognosis Return to top Fever usually reduces in 10 days, and swollen lymph glands and spleen return to normal in 4 weeks. Fatigue may linger for 2 to 3 months. Call your health care provider if Return to top Call for an appointment with your health care provider if symptoms indicate mononucleosis . This could indicate a ruptured spleen, and require emergency surgery.