Also because neurons are so toxin sensitive, SAMe's ability to enhance liver detoxification also protects the brain in our over-chemicalized modern world. Because SAMe tablets are enterically coated, they should NOT be cut in half to achieve a lower dose- the SAMe may then break down before absorption. This side effect is reported far more rarely than the GI side effects. SAMe-induced mania may on rare occasions be serious enough to warrant lithium treatment to end the mania. These five SAMe-metabolism optimizing nutrients will also aid in reducing blood levels of the toxic SAMe metabolite homocysteine.
SAMe is manufactured within the body but it is also made synthetically.
SAMe is a cofactor in a number of critical biochemical reactions and is found in almost every tissue of the body. SAMe has been used in clinical studies to treat depression, schizophrenia, demyelination diseases, liver disease, dementia, arthritis, peripheral neuropthy and other conditions. Depression SAMe alleviates all forms of depression. Liver function SAMe improves and normalizes liver function. SAMe is used in Europe in the treatment of cirrhosis and damage caused by alcohol.