Pay attention to the weather's effect on your pet. If the weather at your destination is radically different from your home, take precautions. Too hot and too cold temperatures can have serious consequences. Extremely hot pavement can burn paws. Frostbite on feet, ears and tail is a possibility.
Road salt needs to be washed from animals' feet.
Take a direct flight if possible. Fly with your pet accompanying you in the cabin if at all possible and reasonable. Cats and some dog breeds can have respiratory problems in the baggage compartments. If your pet cannot travel with you in the cabin, make sure that it will be traveling in a pressurized and heated baggage compartment, on the same flight as you. Keep a leash in your carryon bag, not with the animal.