In our efforts to prepare longer amino acid chains which contain a thioamide at a specific location, we have modified classical liquid phase peptide techniques. Ala. These amino acid sequences were spotlighted due to their structural similarity to collagen and collagenase inhibitors. Future work will involve testing of these compounds as inhibitors of collagenase. Department of Chemistry, University of Central Oklahoma, Edmond, OK 73013. Department of Chemistry, Kansas State University, Manhattan, KS 66506.
Most carcinogens metabolize to electrophiles that react with DNA causing alkylation.
The regioselectivities of the electrophiles dimethyl chlorinium cation and methoxy methyl cation were studied in the gas phase by tandem mass spectrometry using 2-hydroxypyridine as a nucleic acid model. Department of Physical Sciences, Southeastern Oklahoma State Univ., Durant, OK 74701. Potentiometric titrations of ligands solutions are used to calculate pK a values for the ligands. D.G. Wyckoff, N.J. Czaplewski, B.J. Carter, and J.L. Theler, Oklahoma Archeological Survey, University of Oklahoma, Norman, Ok. Erosion of a modern farm pond dam on the Canadian River's first terrace in eastern Dewey County exposed a cross section of buried, fossil-rich, gleyed sediments.