Presumably the same as the above drugs. May also see CNS effects including psychosis. The same as for quinine. The exact mechanism is unknown. It may be due to an oxidant effect of the drug, since electron-carrying redox intermediates are formed.
Resistance does develop to the efficacy of primaquine.
Same as previous drugs. Pyrimethamine is a sulphonamide-type antibiotic that works by inhibiting bacterial and protozoal dihydrofolate reductase, thereby decreasing protozoal protein synthesis. Resistance may develop to its efficacy. A tetracycline antibiotic that is effective against Plasmodium. It is used for multi-drug resistant cases of malaria.