A cancer of antibody producing plasma cells which are not end-stage cells, but which continue to divide in an unregulated way. Involved in host defense against tumor cells, interacting in two ways. Cell death due to cell injury. In the process of necrosis, the cell will swell, burst, and release its cytotoxic intracellular components. These components, when they reach the surrounding cells, will lead to a inflammatory response.
Mice are hairless and can accept grafts from other species.
This molecule that enhances phagocytosis by binding to both antigens and macrophages. A mouse with Severe Combined Immunodeficiency Disease suffers from a failure to develop mature T and B cells and is therefore severly immunologically compromised. SCID mice are good models for studying the human immune system and contributed greatly to the study of bone marrow transplantation. Occurs in non-germ line cells of body. Remember that the immune response takes place without any regard to an antigen.