It was found the ventromedial hypothalamus was the most effective site for inhibition of male sexual behavior by androgen blockers, since males given hydroxyflutamide were unable to mount, intromit, or ejaculate in the majority of testings. Needless to say, many tests have been done on female rats and their sexual behavior to the ventromedial hypothalamus, and this test confirms that sexual behavior in this area of the brain is related to both sexes. Leptin facilitates and inhibits sexual behavior in female hamsters. All female mammals, if not properly nourished, will have problems with fertility and ovulation. Oxidation of glucose and fatty acids effect the neuronal circuits controlling these reproductive behaviors.
Obese rodents lack leptin, whereas, underweight rodents have an abundance of leptin.
Three weeks later, estrous behavior was induced by subcutaneous injections of estradiol benzoate and progesterone. Deprivation of food is anticipated to curb lordosis in hamsters by decreasing estrogen receptor immunoreactive cells in the ventromedial hypothalamus. VMH is the primary area that estradiol arouses female sexual behavior. In food-denied hamsters given leptin, inhibition of lordosis occurred. Leptin neither affected the VMH, nor decrease food intake or weight gain in significant statistical evidences.