Stress causes the heightened release of serotonin, and if the stress lasts too long, it leads to serotonin depletion. Abundant laboratory research suggests there is a deficiency of serotonin or serotonin activity in the brains of most depressed persons., Suicidal patients show a significant decrease in serotonin levels. However, some depressed persons find relief from a daily dose as small as 25 mg., which involves splitting the purchased capsules or tablets. For some people, 5-HTP has an extremely narrow therapeutic window. The proper dosage may lie within a range as small as 10-25 mg. per day.
Many people notice a favorable mood effect within one or two days of beginning supplementation.
Gradually boosting the dose by 25 mg. As with tryptophan, it is important to take 5-HTP away from any protein food. One product manufacturer suggests taking it 45 minutes before or three hours after a protein meal.