Trash collection day on the ISS, though, is a bit different. It isn't as easy as dragging a few cans to the curb. Whenever the Space Shuttle docks with ISS, one of the transfers taking place is the transfer of trash. Bags and bags of refuse are loaded onto the Shuttle, which then returns to Earth-trash and all. At times when the Shuttle isn't scheduled for a rendezvous, an unmanned supply vehicle called Progress is loaded with trash and sent back to Earth.
Progress never makes a landing, though.
It's designed to burn upon re-entry into the Earth's atmosphere, and all that trash is burned up along with Progress.