Take advantage of the assistance they can offer. I usually consult the timetables myself first and write down my plan, then confirm this with the information desk. Written communication is easiest and safest. Most stations have ATMs and longer-hours money exchange desks. Those in an exchange jam can often change money at ticket windows, too.
People traveling light can fit two rucksacks into one locker, cutting their storage costs in half.
Most stations have comfortable waiting rooms. Those with fancy tickets often enjoy fancy business class lounges. The bigger stations are equipped with day-hotels for those who want to shower, shave, rest, and so on. Some stations boot everyone out from about midnight to 6 a.m. Ask before you bed down. Thieves work the stations in the wee hours.