They would do things a bit fancier, artsier perhaps. That's a tough question. I'm not sure. A lot of pagination requires some knowledge about newspaper layout, newspaper design, the functions of newspapers. Probably the biggest difference is scale.
People tend to use desktop for newsletters which are basically words and some graphics.
I think they're pretty much the same. Desktop was probably the forebear of paginating. Desktop software is probably easier to learn and work with, at least starting up. As you get into bigger pages, more detail, then you have to a have more powerful software engine. The specialization comes with programmers, the systems people who design networks and the entire way it works.