In this condition, the RBCs assume an elliptical shape, rather than the typical round shape. Typically, the affected RBCs are small, spherically shaped, and lack the light centers seen in normal, round RBCs. The abnormal hemoglobin causes red blood cells to assume a sickle shape, like the ones seen in this photomicrograph. Malarial parasites are visible within the red blood cells. They are stained a dark bluish color.
Malaria is a disease caused by parasites.