Preventive therapy is an important element of syphilis control efforts.
G benzathine are available for treatment of incubating syphilis. Participants were evaluated serologically for 3 months. Among 96 participants enrolled, none of 40 evaluable persons in the azithromycin group and none of 23 evaluable persons in the penicillin group developed evidence of syphilis. A single 1.0-g dose of azithromycin seems to be efficacious for prevention of syphilis in persons exposed to infected sexual partners. Ann Intern Med.