Unfortunately, prednisone is also hard on the kidneys. It can cause personality changes and weight gain. It is likely to cause incontinence, which is something older spayed females are likely to have anyway. Greta took 1 mg of DES once a week and it controled that. If I forgot, she wet the bed on the 9th day.
Prednisone is anathema to holistic vets.
Greta slept with me and under a blanket, so I could tell. She sweated when she was not doing well. If Maggie does that there is a Chinese herbal blend made by Health Concerns called Coptis Purge Fire. I believe this medicine kept Greta alive while she was eating food that caused an allergic reaction. Some of them actually mix up meds for dogs, but it is likely to be quite expensive.