Doing his post graduate work in radiation oncology at the Johns Hopkins School of Medicine he was attracted to the clinical and basic research problems posed by the development of androgen-independent prostate cancer. He recently joined the University of Chicago faculty in the Department of Radiation and Cellular Oncology. Spatial and temporal control of gene therapy using ionizing radiation. The increase in tumour control was achieved without an increase in normal tissue damage when compared to tissue injury from radiation alone. Control of gene transcription by ionizing radiation in vivo represents a novel method of spatial and temporal regulation of gene-based medical treatments.
Genetic radiotherapy overcomes tumor resistance to cytotoxic agents.
TNf protein in P4L tumors was induced by radiation as high as 29 times control levels and remained detectable for 14 days. Our data indicate that combined gene therapy using liposomes, together with ionizing radiation to locally activate the induction of a radiosensitizing protein, is successful at overcoming resistance to both TNF and radiation. Gene therapy targeted by ionizing radiation. International Journal of Radiation Oncology, Biology, Physics. Ionizing radiation can be used to activate the transcription of exogenous genes that encode cytotoxic proteins.