An important component of stress response is the posttranscriptional modulation of gene expression. Such regulation provides a mechanism to rapidly change the profile of expressed genes in response to stress stimuli. RNase-L mediates the cytostatic, antiviral and proapoptotic activities of this pathway. Cell Death and Differentiation 5, 313-320. RNase-L mediates the antiviral effect of interferon through a selective reduction of viral RNA during encephalomyocarditis virus infection.
Liposome treatment induces interferon synthesis and activation of interferon-stimulated genes.
J. Interferon Cytokine Res. Genomics 19, 174-175. Cell 72, 753-765.