A level of 20000 ppm has been considered just tolerable, and above this level the atmosphere was described as intolerable and suffocating on even brief exposures. Additionally, exposure of animals to various concentrations has resulted in excitation followed by ataxia, incoordination, prostration, twitching, general paralysis, dyspnea, and occasionally death due to respiratory failure. Tolerance may be a factor in individual response to a given air concentration. Reproductive effects have been reported in animals. Direct contact with the liquid may cause immediate burning and stinging, with reflex closure of the lids, tearing, temporary injury of the corneal epithelium,and hyperemia of the conjunctiva.
Healing is usually spontaneous and complete.
Depending on the concentration,contact with rabbit eyes may cause a response ranging from mild irritation to severe injury. Sensitization has occasionally been reported to occur in some individuals resulting in allergic contact dermatitis in the form of eczematouseruptions or, rarely, erythematousflush or contact urticaria at the exposed site. Animal studdies indicate that, depending on concentration and duration of exposure, varying degrees of irritation may occur ranging from mild to severe. A 31-day modified draize open test study resulted in no irritation in men, whereas an occlusive test resulted in erythema and induration toward the end of the exposure period. Other symptoms may include flushing of the face, dilated pupils, rapid pulse, nausea, vomiting, sweating, and diuresis.