Atherogenic high-fat diet reduces bone mineralization in mice. Mice susceptible to artherosclerosis were fed a high or normal fat diet, and those on the high fat diet had significantly lower bone density. This is particularly interesting in view of epidemiological studies that show a higher incidence of osteoporosis in persons with atherosclerosis, cardiovascular disease, or aortic calcifications. I had to make a separate page about statins . Fat metabolism and leptin Fat metabolism also is related to both arteriosclerosis and bone metabolism.
Obese patients have higher risk of coronary artery disease and lower risk of osteoporosis.
Moderate energy restriction increases bone resorption in obese postmenopausal women. Bone minerals changes in obese women during a moderate weight loss with and without calcium supplementation. Two more studies showing even moderate weight loss due to dieting in obese women leads to bone loss. The loss in bone density was attenuated by calcium supplementation. Prevalence and Predictive Factors for Regional Osteopenia in Women with Anorexia Nervosa.