Use with caution in patients with hepatic disease. Gastrointestinal motility agents oppose the effects of diphenoxylate. Diphenoxylate combined with an MAOI may result in a severe hypertensive reaction. To be safe, ensure a 2-week washout period before using the diphenoxylate. If this is not possible, use with caution.
Naloxone can interfere with the therapeutic effects of diphenoxylate and precipitate withdrawal.