A method for screening cosmid libraries with mega insert yeast artificial chromosomes. Detection of 9p deletions in leukemia cell lines by interphase fluorescence in situ hybridization with YAC-derived probes. Refined mapping of genomic rearrangements involving the short arm of chromosome 9 in acute lymphoblastic leukemias and other hematologic malignancies. Familial myeloid leukemia associated with loss of the long arm of chromosome 5. Leukemia 10, 669-674, 1996.
Homozygous deletion is the most common mechanism of inactivation.
Preferential loss of p16INK4a rather than p19ARF in Breast Cancer. BRCA1 testing in families with hereditary breast - ovarian cancer. Overexpression of BCLX protein in primary breast cancer is associated with high tumor grade and nodal metastases. Generation of small insert genomic FISH probes with high signal intensity suitable for deletion mapping. Scaffold associated regions in the human type I interferon gene cluster on the short arm of chromosome 9.