This is yet another example of the critical importance of transition state stabilization as the primary factor explaining the catalytic activity of enzymes. The triose phosphate isomerase mechanism is an example of concerted acid-base catalysis. Many electron transfer reactions involve transferring electrons from one protein to another. For small molecules that are substrates for enzymes, electrostatic interactions are often critical. Here is an example involving sulfite oxidase.
Many enzymatic reactions are complex and involve more than one substrate.
Here is an example involving glutathione reductase. Enzyme Catalysis-Summary Enzymes accelerate reactions using General acid catalysis. General base catalysis. Metal ion catalysis. Proximity and orientation effects.