The disabled with some skeletal deformity, pain and disturbance on physical movement, multiple proximal renal tubular dysfunction, and osteomalacia combined with osteoporosis having developed after their middle age, particularly after their menopause. Table 3 and Table 4 show the skeletal X-ray findings observed on our autopsied series. 2a and Fig 2b demonstrate Looser's zones in a patient before and after the activated vitamine-D treatment. The ribs are most frequently and severely affected. The characteristic pathological changes in itai-itai disease consist of the renal lesion and the bone lesion.
Metastatic calcification is common.
In the advanced cases tubular changes occur also in the distal protion. It is noted that the cadmium content in the patients is remarkably high in the liver, pancreas, and thyroid. Note the difference of the cortical thinning in the middle one and the right one. The details of the bone lesion are listed in Table 5 . Although osteoporosis is a common condition in the aged subjects, that in itai-itai disease patients is significantly over in the general population.