Depo-Provera has been associated with a higher incidence of depression, although it is unclear whether the contraception was the cause. Some studies indicate that those who take Depo-Provera may be at risk for decreased bone density, but this incidental effect appears to be reversible. The injections do not provide protection against sexually transmitted diseases, however, so women at risk for infection should use a barrier contraceptive in addition to the injections. Unlike with progestin injections, a woman will have regular monthly menstrual cycles using the combination injection. She may, however, experience a change in bleeding patterns after the injections, including bleeding that last more than a week.
Pregnancy is possible within two to four months after stopping the injections.
At this time, the recommendations for use of these contraceptives are similar to those for combination oral contraceptives. Lunelle does not protect against sexually transmitted diseases. Lunelle Study Group. Results of an international, multicenter, case-control study. World Health Organization Collaborative Study of Cardiovascular Disease and Steroid Hormone Contraception.