The Project is part of the Pharmacogenetics Research Network and Knowledgebase. Information about the entire Network can be found at PharmGKB . Pharmacogenetics is the study of the genetic basis for variation from person to person in response to drugs.
Membrane transporters play a major role in drug response in two ways.
First, many drugs work by affecting function of transporters. Second, transporters determine the level of drugs within the body and thus determine whether drug levels are adequately high for therapeutic effect. The goal of the UCSF PMT Project is to understand the genetic basis for variation in drug response for drugs which interact with membrane transporters.