3.They both have ribosomes. The major and extremely significant difference between prokaryotes and eukaryotes is that eukaryotes have a nucleus and membrane-bound organelles, while prokaryotes do not. The organelles of eukaryotes allow them to exhibit much higher levels of intracellular division of labor than is possible in prokaryotic cells. Cell Wall Prokaryotes have a cell wall composed of peptidoglycan, a single large polymer of amino acids and sugar. Many types of eukaryotic cells also have cell walls, but none made of peptidoglycan.
Prokaryotic cells are relatively simple.
Staphylococcus aureus Eukaryotic cells are more complex. The nuclear envelope allows selective exchange of materials. Chromatin consists of DNA and its associated proteins. The nucleolus is the site of ribosome assembly. The Membrane System of the Cell Membranes consist of a double layer of phospholipids in which proteins are embedded.