The probabilities that a mutation will survive or eventually spread in the course of evolution tend to vary inversely with the extent of its somatic effects. Most mutations with large effects are lethal at an early stage for the individual in which they occur and hence have zero probability of spreading. Each mutation occurring alone would be wiped out before it could be combined with the others. They are all interdependent. The doctrine that their coming together was due to a series of blind coincidences is an affront not only to common sense but the basic principles of scientific explanation.
Most biological reactions are chain reactions.
To interact in a chain, these precisely built molecules must fit together most precisely, as the cog wheels of a Swiss watch do. For if any one of the specific cog wheels in these chains is changed, then the whole system must simply become inoperative. Saying it can be improved by random mutation of one link . . To get a better watch, all the wheels must be changed simultaneously to make a good fit again. In breadth and content, it is larger than any other single written collection of anti-evolution material.