Over the last 20 years this laboratory's research has been in the field of hypertension. In particular, the role of enfogeneous natriuretic factors in the mechanism of low renin, olume expanded type of hypertenion. The research involves not only understanding the basic mechanism of this type of hypertension, but also its preventiona and treatment. Therefore, several types of new antihypetnesive agents are under study to investigate their efficacy and the mechanism of action. More recently, in association with NASA, the role of endogenous natriuretic factors like sodium-potassium pump inhibitor and atrial natiruretic fator in the dconditioning of the cardiovascular system in simulated weightlessness is under investigation.
Hemorrhagic shock is a dreaded complication of severe battlefield injuries.
The present study searches for a therapy that will maintain tissue perfusion after the onset of the decompensation phase of hemorrhagic shock. This intervention could significantly improve the overall survival rates in the combat wounded. Pregnancy in aviators is cause for medical grounding. Natural progesterone does not appear to interfere with the cardiovascular protective effects of estrogen. However, synthetic forms of progesterone present in commonly prescribed OC have been shown to produce susceptibility to coronary vasospasm in primates.