Nat mur is indicated if the person is emotionally upset. The herpes that are relieved by Rhus tox usually burns and itches, and acrid fluid may seep from yellow vesicles. Rhus tox is effective for the tissue crusting that occurs with herpes. Can be used after Nat mur to finish off the cold sore. People needing sepia have herpatic eruptions around the lips, corners of the mouth and particularly around the nasal area with crusty eruptions inside and on the nose.
People needing sepia often have dark circles under their eyes and are exhausted and depressed.
Sepia is appropriate for cold sores that occur during pregnancy, before menses or in menopause. People needing this remedy can have thick, brown herpatic crusts with reddish borders. These crusts can bleed when scratched. Dulcamara is appropriate for blisters that appear in clusters and ooze watery fluid. Glandular swelling, burning, stinging and itching sensations may be present.