Other recent trials found little or no benefit. Several large double-blind studies vs placebo or azathioprine. Bone marrow suppression and herpes zoster reported Phase II trial completed. Requires definitive study Interferon alpha Relapsing-remitting MS Significantly reduced exacerbation rate and MRI lesion development Pilot trial completed. Side effects limited Phase III trial in 251 patients completed.
Patients report improved ambulation and reduced fatigue.
Causes dizziness and gait instability. No benefit in another. Causes paresthesias and abdominal pain. I studies Glial repair Unknown Incubating growth factors with glial precursors could promote proliferation. Injecting the resulting cells into demyelinated areas could promote remeylination In vitro and animal studies.