We are using the platelet as a model system for examining membrane receptor-mediated reorganization of the actin cytoskeleton.
Platelets circulate in the blood as resting cells in the shape of discs.
The role of platelets in hemostasis requires the timely and selective activation of the resting platelet. Fundamental and necessary in this process is a shape change that transforms the platelet from a smooth disk to a flattened form with fingerlike projections. This shape change requires modifications to the actin-based cytoskeleton that allows polymerization of actin filaments. Barkalow, K., W. Witke, D. J. Kwiatkowski and J. H. Hartwig. Coordinated regulation of platelet actin filament barbed ends by gelsolin and capping protein.