Learn the main classes, spectrum of activity and important side effects of antifungal agents. Dermatophytes have environmental, animal, and human reservoirs. Short courses of therapy are highly effective for treatment of nail bed infections due to Trichophyton species. Sporothrix schenckii is found as a mold in both the environment and in tissue.
Granulomatous inflammation is uncommon in sporotrichosis.
Staining of material from the skin lesions shows septated hyphal structures. An unconscious patient with AIDS diagnosed with meningitis who has yeast in CSF and blood cultures. A renal transplant patient with yeast in multiple sets of blood cultures. A patient is in the intensive care unit with pneumonia unresponsive to broad-spectrum antibacterial agents. Large yeast with broad-based buds are seen on KOH staining of sputum.