Vomiting is less common than with erythromycin. It should be given on an empty stomach. Cross-resistance with erythromycin is common. Cross-resistance with lincomycin is common. It is indicated for deep infections especially in patients with infections in deep fibrotic tissues.
Resistance develops rapidly and bone marrow suppression has been reported as a possible side effect.
Potentiated sulfonamides are commonly used to treat superficial pyoderma. They work by inhibiting the synthesis of folic acid. Potential side effects are keratoconjunctivitis sicca and multi-systemic drug induced hypersensitivity like type III Arthus reaction. Doberman pinschers are predisposed, however caution for long term therapy should be used in any breed. Multi systemic reactions include fever, arthritis, glomerulonephritis, polymyositis, erythema multiforme, toxic epidermal necrolysis, anemia, leukopenia, and thrombocytopenia.