They are pro-inflammatory substances which are released when mast cells are exposed to allergens. In the lung, leukotrienes trigger bronchoconstriction, inflammation, and edema. A similar type drug will hit the market about the end of the year. Where Accolate blocks the effects of leukotrienes, Leutrol blocks the production of leukotrienes. One advantage is that Accolate is given orally.
Many patients prefer tablets over using an inhaler.
Some physicians will use Accolate first instead of inhaled steroids to increase benefits without increasing steroid doses. Efficacy is a big question. Preliminary tests suggest that Accolate is about as effective as inhaled cromolyn. To increase absorption, take on an empty stomach.