It is effective regardless of the etiology of the inflammation. This prolonged half-life results in the maintenance of relatively stable plasma concentrations throughout the day on once daily doses and to significant drug accumulation upon multiple dosing. Higher levels, which approximate steady state at two to three weeks, have been observed in patients in whom longer plasma half-lives of piroxicam occurred. The effects of impaired renal function or hepatic disease on plasma levels have not been established.
Efficacy is seen in terms of pain relief and when present, subsidence of inflammation.