What sets it apart is the completely original setting where it takes place. With a real Old West frontier feel, yet in some ways advanced technologically, the setting has a real feel of the frontier of futuristic exploration, where a man is judged on his deeds, and the law is often sparsely enforced. In this realm we are introduced to Vash, a man with a shadowy past, and dubious abilities. As well, the character designs are great, with a well thought out and executed western theme. Everything ties into this theme without becoming cliche or tired.
Picture quality is top notch, and the sound is crisp and clear in both English and Japanese tracks.