As the naltrexone leaves the receptor sites the site may be rushed with opioids in quantities greater than the user's current tolerance level. This situation is more critical when methadone is being used. This is because a dose of methadone can last in the body for 24 hours, during which time the amount of naltrexone in the body is declining. This means that a dose of methadone, which initially has no effect, may over several hours come to produce serious overdose effects. Black market use Using naltrexone outside the supervision of a doctor can be risky.
Naltrexone is one of a range of treatment options for opioid dependence.
Deciding to undergo naltrexone requires careful consideration. The important thing to remember is that you must detox first. Naltrexone is not a euphoric alternative to heroin or other opioids. It's a drug which blocks euphoric effects and helps you maintain abstinence. Taking naltrexone medication is only part of the treatment.