Whether and how Dep-1 regulates neural tube formation, or any other biological processes, awaits further investigation. We are grateful to Dr. C.R. Kahn for helpful comments and to Dr. Marc Montminy for critical reading of the manuscript. N-CAM alterations in splotch neural tube defect mouse embryos. Pax-3, a novel murine DNA binding protein expressed during early neurogenesis. Analysis of the Pax-3 gene in the mouse mutant splotch.
Retinoic acid induces embryonal carcinoma cells to differentiate into neurons and glial cells.
Reduced expression of Pax-3 is associated with overexpression of cdc46 in the mouse embryo. From the Section on Molecular Biology, Joslin Diabetes Center, and the Department of Medicine, Harvard Medical School, Boston, Massachusetts. Address correspondence and reprint requests to Mary R. Loeken, Joslin Diabetes Center, One Joslin Pl., Boston, MA 02215. Received for publication 5 November 1997 and accepted in revised form 6 August 1998.