Conjunctivitis and episcleritis may also occur and are the most common eye manifestations. Sweet syndrome has the potential to involve several other organ systems. Pulmonary manifestations are the most common extracutaneous findings and may manifest as a chronic cough or pulmonary infiltrates on chest x-ray. Proteinuria, hematuria and decreased creatinine clearance have been reported. Cerebral spinal fluid pleocytosis has also been described, as has a sterile chronic recurrent multifocal osteomyelitis in children.
Lesions occur in areas of trauma such as bites, scratches and venipuncture.
Hematologic malignancy Myelodysplasia and chronic myelogenous leukemia may be associated with Sweet's syndrome. Multiple infections have been described in association with Sweet syndrome. These infections usually involve the upper respiratory tract. Streptococcal pneumonia is the most commonly described infection and Yersinia-associated Sweet syndrome has been noted to improve with antibiotics. Atypical mycobacterial infection has also been described in several patients.