It usually shows up as tingling, numbness, or a sharp burning sensation in the feet, legs, or hands. The nerve damage is usually temporary and will go away if you stop taking ddI, or reduce the dose. If you continue to take ddI after nerve damage shows up, it may become permanent. See Fact Sheet 553 for more information. Pancreatitis is an inflammation of the pancreas, a large gland located behind the stomach.
Pancreatitis can be fatal.
If you are taking ddI and have sharp pain near your stomach, back, or sides, with nausea and vomiting, stop taking ddI immediately and call your doctor. Lactic acidosis is a buildup of lactic acid in the blood. This is a by-product of abnormal energy production by the cells. It may be caused by damage to the mitochondria. See Fact Sheet 554 for more information on mitochondrial toxicity.