Protonated THAM is excreted by the kidneys and acts as an osmotic diuretic. It is most appropriately administered as a short-term infusion during a therapeutic window to correct an acute episode of respiratory acidosis. Precautions THAM may induce respiratory depression and hypoglycemia, which may require ventilatory assistance and administration of glucose. Intratracheal pulmonary ventilation in premature infants and children with intractable hypercapnia. Medicine is a constantly changing science and not all therapies are clearly established.
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