Trimethroprim, a folate analogue blocks another step in the pathway, dihydrofolate reductase. Used together, an example of synergism. Unfortunately, it is toxic to kidneys. A. Prescription drugs 1. Half are used for human treatment of which maybe half is appropriate.
Physicians often prescribe antibiotics on demand.
Patients stockpile unused antibiotics, or fail to observe full course of treatment. The amounts are too low to combat infection, but supposedly promote animal growth. In agriculture , sprayed on crops and this is consumed. This is certainly unnecessary, but more importantly, may select for resistant bacterial. Due to their OM, gram-negative bacteria are more resistant to lipophilic and amphiphiic inhibitors such as dyes, detergents, and antibiotics.