A complementary set of replacements placed in a distantly related enzyme, isopropylmalate dehydrogenase, produced the converse switch in coenzyme utilization. Such studies are beginning to provide insights into the relations between protein structure and protein function that are critical to the rational design of drugs and industrial biocatalysts. Chen, R., A. Greer and A. M. Dean. 1996. Redesigning secondary structure to invert coenzyme specificity in isopropylmalate dehydrogenase. Dean, A. M. and G. B. Golding.
Protein engineering reveals ancient adaptive replacements in isocitrate dehydrogenase.
Redfield, R. J., M. R. Schrag and A. M. Dean. 1997. Dean, A. M. 1998. The molecular anatomy of an ancient adaptive event. American Scientist . Golding, G. B. and A. M. Dean.