My father 65 has had multiple abdominal surgeries for this syndrome. Presently he has metastic liver cancer from his colon. Paternal grandfather 88 has visible skull osteomas and palpable abdominal masses. I know there have been a past study on Sulindac and an unpublished recent study of Celebrex, but I am unaware of any on Daypro or Arthrotec. This enzyme is important in the formation of compounds called prostaglandins.
Prostaglandins have a variety of effects throughout the body.
On the other hand, sulindac does not totally eliminate the presence of adenomatous polyps. Therefore, the risk of colorectal cancer is still present and one cannot currently recommend the use of sulindac alone. Colectomy still remains the best chance to prevent colon cancer in patients with FAP or Gardner's syndrome. The current recommendation for the screening of patients with attenuated familial adenomatous polyposis or Gardner's syndrome includes a colonoscopy beginning at the age of 10-12 years and then performed every 1 to 2 years until age 40 and every 3 years thereafter. If duodenal disease is mild, surveillance endoscopy is recommended every 2 to 3 years.