Normal neutrophil function requires surface adhesion and phagocytosis. Several receptors on neutrophils mediate these functions. A reduction in neutrophil CD11b and CD16 expression after severe traumatic injury correlates with increased septic complications. Granulocyte CD16 deficiency is usually asymptomatic, although iso- immune neonatal neutropenia in offspring of deficient mothers has been reported. This rare disorder is usually detected in infancy or childhood and results in recurrent, often life- threatening, bacterial infections.
Neutrophils are normal morphologically, but exhibit defects in motility and phagocytosis.
The percentage of patient neutrophils bearing these receptors is reported. In addition, the receptor surface density of each antigen is compared to normal neutrophils and expressed as a percent. Values outside of the reference intervals may correlate with abnormal neutrophil function. This test was developed and its performance characteristics determined by ARUP Laboratories. It has not been cleared or approved by the U.S. Food and Drug Administration.