Genetic Linkage analysis, positional cloning, inherited neurologic and psychiatric disorders. We are also using genetic linkage analysis to identify chromosomal loci of genes responsible for dominantly inherited, early-onset dementia and other neurologic disorders. Developmental regulation of neuronal cytoskeleton. MAPs regulate microtubule stability and are therefore important factors governing the balance between neuronal rigidity and plasticity. MAP1a causes microtubules to be more stable and thus stabilize axonal shape.
MAPs are under strict developmental regulation.
Using transgenic mice, we are identifying the genetic regulatory elements of MAP1a in order to analyze the molecular genetic cascade that regulates microtubule stability. Tight linkage to chromosome 2q. Further localization of a gene for paroxysmal dystonic choreoathetosis to a 5 cM region on chromosome 2q34. For site credits, questions, or comments click here for the webmaster .