Another Egr family member in Drosophila is Klumpfuss .
Molecular analysis shows that sr encodes a predicted protein containing a zinc finger motif.
In mammals, expression of egr genes is induced by intercellular signals. CKII also phosphorylates, albeit weakly, fragments 5 and 8, which respectively cover part of the activation domain and the entire repression domain of Egr-1. Subsequently, epithelial signaling leads to mesenchymal induction of BMP-4 expression. These beads induce a translucent mesenchymal zone similar to that induced by dental epithelium. BMP-4 also induces its own mesenchymal expression.