When you fail to ovulate or produce an egg, no progesterone is produced and bleeding becomes erratic. There are many drugs to choose from. Once this has been done, you should be fine. She gets down right nasty. She is just starting menopause.
Psychological changes can be part of menopause.
I would advise you and your wife to read my book. If you both understand what is going on, it makes it easier to deal with. There are many alternatives that can help, such as deep breathing with the onset of hot flashes, cooling off your bedroom two hours before sleep to decrease hot flashes, avoiding alcohol and hot coffee and tea, avoiding spicy food and exercising. I feel strongly that if you both understand why these symptoms are occurring, you can find a way to deal with them. Hormone replacement for some period of time or anti depressants or counseling can also help.