No extra benefit was provided by the 450 mg dose. Researchers have different theories about how DHEA alleviates depression. DHEA can affect serotonin, GABA receptors and other brain factors. A recent study indicates it might modulate the serotonin signaling pathway. DHEA also has anti-stress effects that may be part of its antidepressant action.
Research shows that cortisol, the stress hormone, is elevated in major depression.
DHEA counteracts cortisol. People who practice transcendental meditation have higher levels of DHEA than those who don't. Exercise has been reported to enhance mood. In turn, DHEA has positive effects on the heart. One way DHEA is good for the heart is that it keeps arteries clear.