It does not require repetitious training. Neo's are very attuned to his master's wishes. This breed rarely gives trouble by excessive barking. They are serious, calm and quiet unless provoked. The breed is very wary of strangers.
Males can be much more aggressive and dominant than females.
The Female makes a better family pet, as she is more submissive to her master and better with children. These dogs are, however, usually very loving with children, provided they do not tease them. Males do not get along with other males, but the Neo can get along well with non-canine pets if raised with them from puppyhood. The Neapolitan Mastiff is not a breed for everyone. They must have a dominant owner capable of controlling him properly.