Other texts use addiction and dependence interchangeably, adding 'physical' to describe classical addiction. Others are prescribed , and can only be legally acquired through a prescription, such as ketamine. A few drugs, such as marijuana, are prohibited , and cannot be acquired legally. The legal status of a drug seems to have no relation to its safety or intoxicating effects. Severe criminal and civil penalties can result from using prohiited drugs, including jail and loss of property.
Punishment can exceed that for murder and rape.
Tolerance Some drugs cause tolerance after use. Tolerance makes the user less susceptible to the intoxicating effects of the drug, as well as less susceptible to the lethal effects of the drug. Little, Brown, 1972. Houghton Mifflin, 1993. A Primer of Drug Action Dr. Robert M. Julien.