Later, a full length positive RNA is transcribed and this is used to produce the full length negative strand RNA that is packaged into progeny. Rhabdoviruses generally enter via a bite or a wound infected with saliva. CNS damage produces the symptoms of disease. Infection of the thalamus, hypothalamus or pons may occur. Symptoms include fever, excitation, dilation of the pupils, excessive lacrimation, salivation, anxiety, hydrophobia due to spasms of the throat muscles and, eventually, death.
Many factors come into play.
Interferon, humoral factors and the cell-mediated response are all important. Approximately 10,000 humans become infected per year worldwide. Direct immunofluorescence is a highly specific and sensitive method. 1997-2001 Douglas F. Fix. All rights reserved.