As we age, our ability to maintain healthy cartilage may decline. The enzymes that repair and restore the cartilage is reduced and the water needed in the joint decreases. Without water and the healing enzymes, the joints becomes more prone to damage. Currently, many believe that OA and RA are caused by the action of matrix enzymes. Some of these enzymes are proinflammatory.
Inflammation is the tissue response to some chemicial, immunoligical or mechanical stress.
It is usualy accompanied by arachidonic acid. This acid is present in the production of what is called prostaglandin PGE2. PGE2 is an important element in the production of inflammation. Researchers hope that reducing or eliminating these inflammatory elements could lead to a new and more effective treatment of arthritic conditions. There is a gradual breakdown that often affects the weight bearing joints of the knees, hips, hands and spinal joints.