While temporal lobe seizures may not be present in your case, temporal lobe dysfunction can clearly cause these symptoms. In my experience, no, the meds do not stop working. Other things happen. The problem with the BPD is that when dysphoria becomes chronic it is assumed that Prozac has stopped working when in reality additional things are wrong. Whether meds are needed for life or not depends upon the individual.
Many people seem to heal, like a stroke patient, when life has changed dramatically.
I view it's a medical problem first, although the therapist may be necessary as well. I give an instruction sheet to my patients explaining when and how to use as needed medications.