And these were women who did not have a major depression. I would put them on Prozac for just four or five days, on their PMS days, and they got tremendous benefit just with this pulse luteal phase dosing from the Prozac. I got a lot of flak in writing that article for the newspaper, because a lot of female nurses claimed that PMS is not a psychiatric disorder. What they didn't notice, though, in my article was the whole time I was saying PMS is a physical disorder. What I was saying was that there appears to be something going on in the brain serotonin just during those days.
Progesterone goes up.
Then it starts to go down. Estrogen is dampening down. Something is happening in the interaction between estrogen, progesterone and serotonin, and I was speculating on that. I was emphasizing that premenstrual symptoms are physiological in nature. I fully agree that PMS is a physiological disorder.