However once you get used to this there are only a few rules that you need to know for day to day living. It is not part of the European Union, this may mean that you can work but not your wife, check it out. Assuming that the husband will transfer jobs to Switzerland much of the burden will fall on the wife, since hubby will be at work all day. Since the learning curve is steep the wife should get as much help from the company and other expats as possible. Starting a Swiss-German language course will be a good way to meet other expats in a similar position.
People use trains and buses much more than in USA, they even walk or cycle to work.
A number of my colleagues do not bother to own a car in Switzerland. Beef is expensive, pork and veal are cheaper. One of my colleagues commented that you had better start liking pasta. Also taxes are low. There are certain Cantons where Foreigners cannot buy property.