Neuregulins with an Ig-like domain are essential for mouse myocardial and neuronal development. 96201659 Lee, K. F., et al. Requirement for neuregulin receptor erbB2 in neural and cardiac development. Heregulin is rapidly translocated to the nucleus and its transport is correlated with c-myc induction in breast cancer cells. ARIA can be released from extracellular matrix through cleavage of a heparin-binding domain.
Neurotrophic factors increase neuregulin expression in embryonic ventral spinal cord neurons.
The Neuregulin precursor proARIA Is processed to ARIA after expression on the cell surface by a Protein kinase C-enhanced mechanism. 77-91 Loeb, J. A., et al. Expression patterns of transmembrane and released forms of neuregulin during spinal cord and neuromuscular synapse development. 99112966 Martin-Blanco, E., et al. A temporal switch in DER signaling controls the specification and differentiation of veins and interveins in the Drosophila wing.