Proceed at your own risk. A system backup before making changes is recommended. Editing the Windows Registry can cause major problems if done incorrectly. These changes require a reboot to put them into effect. If you don't use scripting in MS Office, it should be deselected from Options.
More info is available from the links below.
This FAQ includes directions for disabling Mdm.exe by editing the Registry. It is cross platform with a huge potential for security problems. On the other hand, there are lots and lots of ways to make DCOM applications insecure, so maybe one of them is just waiting for somebody to send it an entirely unauthenticated request to overwrite selected files on my hard disk. Firewalls have good reasons for blocking protocols like DCOM coming from untrusted sources. Protocols that sneak them through are not what's wanted.