Avoid use in patients with diarrhea secondary to poisoning or infection. Use with caution in patients with respiratory depression, respiratory disease or CNS depression. Opioids combined with an MAOI may result in a severe hypertensive reaction. To be safe, ensure a 2-week washout period before using fentanyl. If this is not possible, use with caution.
Naloxone reverses the effects of fentanyl.
Apply the fentanyl patch to a flat surface, such as the chest, back, flank or upper arm. Replace the patch every 72 h.