Louis XII of France seizes Milan. Luther posts his 95 Theses in Wittenberg. Hernan Cortes conquers the Aztecs. Diet of Worms. Luther refuses to back down.
Imperial troops sack Rome.
Henry VIII of England breaks with Roman Catholic Church. Jacques Cartier sails up the St. Lawrence River. Hernando de Soto discovers the Mississippi River. Aims to reform Catholic Church. Peace of Ausgburg.