In man and certain other animals, colchicine can produce a temporary leukopenia that is followed by leukocytosis. Colchicine is rapidly absorbed after oral administration. Large amounts of the drug and metabolites enter the intestinal tract in bile and intestinal secretions. High concentrations of colchicine are found in the kidney, liver, and spleen, as well. Colchicine does not appear to be tightly bound to serum protein , hence the drug rapidly leaves the blood stream.
Excretion occurs primarily by biliary and renal routes.