Once in a while we prescribe 3 tablets per day, but higher doses can have additional adverse effects on cervical mucus making it more difficult to conceive. A therapeutic trial on clomiphene is 3 to 6 ovulatory cycles. The chance of pregnancy beyond this is very minimal. More advanced therapy should be considered. Ovulation induction is the therapy given for a disease called Ovulation Disorder.
Ovulation requires a delicate balance of hormones.
The hypothalamus and pituitary are next door neighbors in the brain and work together to ultimately induce production of follicles from the ovaries. The brain monitors how much estrogen is in the body. If it is low, it sends FSH to the ovaries, which helps them develop a follicle, which secretes estrogen. Clomiphene is a drug that fools the brain into thinking that estrogen levels are low. As a result, the brain releases more FSH than it normally would to the ovaries to develop a follicle.