The mean age at diagnosis of patients with tumors in the foot is 17 years.
Patients normally have pain accompanied by significant diffuse swelling.
The area may appear inflamed and a misdiagnosis of infection can be made. The white blood cell count, erythrocyte sedimentation rate and temperature may all be moderately elevated. Patients have symptoms for an average of 14 months prior to diagnosis. Patients with hindfoot lesions have an average duration of symptoms of 22 months prior to diagnosis, whereas those with forefoot lesions have an average duration of symptoms of seven months. The radiologic appearance of Ewing's sarcoma in the foot is highly variable.