Major depression is not usually a side effect of Actigall. Would you encourage or discourage a patient of yours with stage 3 PBC from taking Milk Thistle. Please explain your answer. Hence I would not encourage anyone with PBC, no matter what stage, to take it. I am not aware of any side effects.
Many patients take it on their own because it is sold over the counter.
I would rather not have patients take milk thistle but do not feel strongly because it is seems to be safe in the doses taken. For approximently 3 years I have undiagnosed fevers. Use to be only at night and maybe every three months for a week at a time. The temps at times will go to 105. I have seen numerous doctors about the fevers without any conclusions.