These target oligonucleotides are used in enzymatic and crystallographic studies. Synthesis of DNA lesions using multi-step organic synthesis. Automated solid phase synthesis of DNA strands. Physicochemical and enzymatic investigation of lesion repair. Nature developed during evolution a tremendous series of complex molecules able to perform defined tasks with high precision.
Numerous enzymes catalyse specific reactions.
Oligonucleotides are able to adopt defined three dimensional structures. Our goal is to link these specific biological materials to chemically synthesized functional modifiers in order to generate hybrid compounds and materials with novel functions. We synthesise chemical redox sensors, which are incorporated into oligonucleotides. The generated hybrid compounds are finally attached to gold surfaces in order to create novel analytical devices for DNA analysis. Synthesis of artificial nucleobases and functional modifiers using multi-step organic synthesis.