Heparin should not he administered in the same intravenous infusion fluid because of the risk of precipitation. 200 mg once daily. This dose should then be reduced to half and administered every 24 hours, eg. 200 mg initially, thereafter 100 mg once daily. A maximum daily dose of 400 mg ofloxacin should therefore not be exceeded.
Products inhibiting peristalsis are contra-indicated.
These reactions have occurred mainly in elderly patients and patients with impaired renal function, but not exclusively. In some cases these reactions have occurred already after the first dose. Seizures, and less frequently extrapyramidal symptoms. Vascular purpura and systemic necrotising angeitis may occur in less frequent cases. Acute anaphylactic or anaphylactoid reactions may occur, sometimes even after the first dose.