With S. Taffet, M. Delmar, and J. Jalife.
Potassium channels are a diverse group of ion channels.
Recently, we have started structure-function studies on HERG channels, one member of this class of potassium channels which is present in mammalian cardiac cells. Mutations in HERG have been shown to cause a form of inherited cardiac arrhythmia. Our main goal in these studies is to understand the detailed molecular mechanism of how these channels are regulated during changes in the proton concentration of the cellular environment. Selected References Anumonwo, J.M.B., M. Delmar, and J. Jalife. Electrophysiological Properties of Single Heart Cells from the Rabbit Tricuspid Valve, J. Physiol.