AT is autosomal recessive, and the gene for it has been localized to band 11q22-23. Histopathologic studies of the brain of an affected individual have revealed loss of Purkinje cells, granular cells, and basket cells of the cerebellar cortex. Evaluation usually can be conducted on an outpatient basis. Management of recurrent sinopulmonary infections may require hospital stay and intravenous antibiotics. Monitor respiratory infections.
Physical therapy is indicated.
Death Recurrent pulmonary infections Progressive ataxia leaves the patient wheelchair ridden. Children should have psychologic counseling as they age because of the great disparity between chronological age and mental age in tests involving visual motor coordination. Report of seven cases. Medicine is a constantly changing science and not all therapies are clearly established. New research changes drug and treatment therapies daily.