Facial features are more variable and mild in females than those in males and consist mostly of overhanging brow, hypertelorism, depressed nasal bridge, flat facies, and depressed bridge of the nose.
Most male patients have mild mental retardation.
Flat facies, frontal and occipital bossing and thickening, micrognathia, hypoplastic facial bones, poorly developed paranasal sinuses, and cleft palate occurring mostly in males. Hypertelorism, overhanging brow, prominent supraorbital ridges, downslanting palpebral fissures, and notching on the upper eyelids in affected males. Broad nasal root. The syndrome is familial with parental consanguinity. It is transmitted as an X-linked trait with tentative linkage to Xq28.