Bone turnover in response to 0.25 mg estradiol was similar to that seen with 1.0 mg estradiol. Longer term studies are needed to determine whether the effects on bone turnover seen with 0.25 mg estradiol will translate into increases in bone density and decreases in fractures. Such studies are needed to help the more than 10 million Americans who have osteoporosis, a disease that thins and weakens bones with the most common fractures occurring to the spine, wrist and hip. Some 18 million more have lost enough bone to make them more likely to develop osteoporosis. More than 80 percent of these 28 million people are women.
Osteoporosis is costly both in dollars and in human suffering.
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