Dark punctiform inclusions are seen also in the cytoplasm. 132 - CMV neonatal hepatitis Notice an area of necrosis with nuclear inclusions in hepatocytes and not much inflammatory reaction. Type 1 produces herpes simplex infection especially recurrent blisters around the lips and generalized infections in older children and adults. Type 2 affects the genital tract and produces disseminated infection of the neonate with severe hepatic involvement. In the liver there are macroscopic yellow foci of necrosis and hemorrhage.
Inflammatory response is minimal.
Enlargement and multinucleation may precede the appearance of inclusion bodies. The infection is usually accompanied with disseminated intravascular coagulation. The virions can be demonstrated on biopsy material. The virus is similar to that of herpes simplex and CMV with intranuclear inclusions. It produces chicken pox in children and shingles in the adults.