Previous studies in animals have shown that apoA-1 can slow progression of atherosclerosis. High levels of LDL cholesterol are known to increase an individual's risk of coronary heart disease. High levels of HDL cholesterol, on the other hand, protect the heart and reduce the risk of heart disease. Researchers estimate that at least 25 percent of those who develop coronary heart disease have low levels of HDL cholesterol, and could benefit from treatments designed to raise those levels. This could lead to the development of important new treatments aimed at inducing regression of coronary heart disease, especially in persons with low levels of HDL cholesterol.
Lesions are another term to describe the fatty deposits that block blood vessels.
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