Studies in the United States, Europe and the Far East show that testosterone pellets can maintain a stable hormonal level for up to 120 days. Although there is individual variation from manufacturer and by patient, this delivery system has been the easiest for men to accept when long term replacement is indicated. This is the method most often used in our office. There are no significiant side-effects to this herb. In Europe, testosterone replacement is much more common.
Recent studies imply that U.S. men are misinformed.
Ongoing Research Total testosterone is not as important as the Free or unbound testosterone, as the latter is bio-available to the tissue. High levels of estrogen and sex hormone binding globulin reduce bio-available testosterone. Medical publications show that gels and patches raise sex hormone binding globulin. High levels of testosterone from an intramuscular injection raises the estradiol level. That is why low-level, even release pellets are the best modality available today for the man who needs testosterone replacement.