The primary targets of H2S is the central nervous and respiratory systems. Metabolic acidosis can occur secondary to anaerobic metabolism. Hydrogen sulfide is also a mucous membrane and respiratory tract irritant. Low level of H2S result in irritation of the eyes, nose and throat. Moderate levels can cause headache, dizziness, vomiting, as well as cough and difficulty in breathing.
High levels can cause shock, convulsions, coma and death.
Injured by chronic exposure to H2S experience respiratory problems, neurological dysfunction, such as amnesia, tremor, disturbance of equilibrium, including severe fatigue, headache, and skin problems, more serious brain damage, as well as persistent ill-health following exposure. The cellular processes of H2S toxicity produce a similar endpoint to simple anoxia, but experimentally do not appear to be completely identical. This effect is mediated, in part, by monoamine oxidase inhibition. Oxidized products are excreted primarily by the kidneys and colon. This is a serious deficiency.