Neurones are extremely sensitive to states of anoxia.
The types of damage that are produced within the CNS may present as different signs or symptoms. Sensory function deficits may occur if sensory neurones or that area of the brain innervated by them suffers toxic insult. This type of damage often presents as impairment of sight, hearing, temperature discrimination, pain perception, or non-specific paraesthesias. Damage of this type is often the result of central demyelination or neuropathy that decreases conduction velocity of the neurone. Conversely, toxic insult resulting in increased neuronal excitability could increase the perception of sensory input from these neurones.