Histopathologic examination of inner ears in patients with Waardenburg syndrome shows absent organs of Corti, atrophy of the spinal ganglion, and reduction of nerve fibers. No effective treatment exists for Waardenburg syndrome. Early diagnosis and improvement of the hearing defect are important for the psychological development of children with this disease and help to reduce the sense of isolation. Lack of resources in some societies may add to the physical and psychological obstacles faced by patients with Waardenburg syndrome. Tolerance and understanding of patients with Waardenburg syndrome support their integration into society.
Genetic counseling is a good idea.
Failure to provide genetic counseling for families with this autosomal dominant disorder constitutes a medical legal pitfall. Marked facial asymmetry, lagophthalmos, a drooping right corner of the mouth. Brother and sister with Waardenburg Syndrome. Correlation between Waardenburg syndrome phenotype and genotype in a population of individuals with identified PAX3 mutations . Hum Mol Genet.