They are attempting to establish a correlation between the T cell receptor gene structure and the allograft or tumor specific function. The long-term goals are to use this information to generate reagents which could either eliminate or enhance the function of specifically reactive T cells. In related studies, they are examining the role of protein kinase C in T cell activation and signal transduction. Structure of tumor associated antigen containing a tandemly repeated immunodominant epitope. Chimpanzee dendritic cells with potent immunostimulator function can be propagated from peripheral blood.
Human tumor antigens are ready to fly.