If I can use a literary allusion, chemical reactions are not all equal. Some are more equal than others. The main point of chemical thermodynamics is to predict whether a reaction will have a tendency to proceed in a certain direction or not. Such is the case concerning the origin of life. There are too many unfavorable reactions to ignore.
Living systems are self-reproducing, coded, information systems, for starters.
There are several other things that should be addressed, but I'm sure I've more than primed the pump and these things will come up again.