Peak plasma level reached 4-8 h after a single dose. Archives of Physical Medicine and Rehabilitation . Brain Injury Update. Brain Injury Update. The mechanism of the antidepressant action of venlafaxine in humans is believed to be associated with its ability to inhibit neuronal serotonin and norepinephrine reuptake and its weak inhibition of dopamine reuptake.
Food has no significant effect on absorption.
The o-desmethyl metabolite is active but is conjugated with glucuronic acid and excreted. Potential interactions with drugs metabolized by P-450 enzymes, e.g. diazepam, cimetidine, alcohol and haloperidol. Contraindicated in patients sensitive to the drug. Concomitant use in patients taking MAOIs is contraindicated. Improved arousal and inititation following tricyclic antidepressant use in severe brain injury.