Immediately below that is the area of living epidermal cells. It is within this layer that the various pathologic changes of pemphigus take place. Superficial separation is seen more in pemphigus foliaceus while slightly deeper separation is seen in pemphigus vulgaris. In bullous pemphigoid the separation occurs subepithelially between the epidermis and dermis. The cellular engulfing of large molecules or particulate matter by localized regions of the plasma membrane or cell wall.
Genes are segments of chromosomes found in the nucleus of cells.
This hereditary information usually directs the formation of a protein. A set of genes involved in the presentation of antigenic peptides to the immune system. This role makes them pivotal in the etiology of autoimmunity and transplant rejection. The system protecting the body from infectious and foreign substances. It works with antibodies from B cells and T cells.