A change seems to occur in the rate sebocytes migrate from their points of differentiation into the sebaceous unit. Gland is enlarged with a widened sebaceous duct and an increased number of basal cells. These lesions reveal individual, discreet, enlarged glands. Within each gland, mature sebaceous lobules surround and connect to a central, widened sebaceous duct. Treatments are mostly mechanical.
Lesions tend to recur unless the entire unit is destroyed or excised.
Risk of permanent scarring must be considered when treating benign lesions. Isotretinoin in a daily dose as low as 10 mg per day is rarely indicated as a temporary suppressive treatment for widespread disfiguring sebaceous hyperplasia in a patient with no contraindications and prescribed by a physician expert in oral retinoid therapy. The goals of pharmacotherapy are to reduce morbidity and prevent complications. Retinoids - Isotretinoin has been used in sebaceous hyperplasia because of its ability to shrink sebaceous glands temporarily. Lesions return after discontinuation of therapy.