Whether Enbrel influences fertility is unknown. Irritated injection sites usually improve within 3 to 5 days and rarely require discontinuation of the medication. Injection site reactions most often occur during the first month and gradually subside with time. These usually do not require interruption of therapy. Bacterial and serious viral infections may be more likely, more serious and more difficult to treat in patients taking Enbrel.
Infections can be life threatening.
It is unknown whether the etanercept or other factors were the cause of these reactions, but a relationship cannot be ruled out at this time. There have been other medical problems reported rarely while patients have been taking etanercept. Whether these are due to etanercept or entirely unrelated is unclear. These could be serious, even life threatening. If you feel that you are developing a significant side effect, call your physician immediately.