Scars over areas of friction such as the bra line or the belt line can be subject to constant irritation. There are several reported cases of melanoma developing underneath a skin graft from nevus cells left behind deep in the muscle. This could also occur with skin expanders and laser. Melanoma has also been known to develop in areas of scarring or chronic irritation. Both the nevus and the scar tissue are usually quite fragile and will bleed easily.
Healing is often very slow and wounds can break open.
Diaper rash of the genital area covered by a nevus or by scars is common even as an adult because the skin is so delicate in that area. Some female children have had mastectomies for a nevus involving the skin over the breast. Both constipation and diarrhea should be avoided. They can be minimized by eating high-fiber foods daily. Many surgeries are often necessary to remove a large nevus.