Thus, my research goals are to understand the mechanisms of regulation of manganese superoxide dismutase gene expression by thioredoxin and to understand the role of thioredoxin in hyperoxic lung injury. I am also interested in mechanisms of induction of the thioredoxin system in hyperoxia. Current Projects Role of thioredoxin in manganese superoxide dismutase gene expression. Lay Summary Antioxidant enzymes are important proteins which play protective roles in many types of diseases. The diseases in which antioxidants have been shown to play a protective role are heart attack, stroke, many types of lung diseases, cancer, AIDS, and aging.
Endogenous antioxidants are more efficient in their protective role against diseases.
My research focus is to understand how our endogenous antioxidants are controlled in the body in normal as well as in disease conditions. By understanding the regulation of these proteins, we can design strategies to increase or decrease their production for more effective treatments. Selected Publications Das, K.C. and H.P. Misra. Das, K.C. , Y. Lewis-Molock, and C.W. White. Das, K.C. , Y. Lewis-Molock, and C.W. White.