A single male with curled pelage hairs was identified in a litter of 6.
Littermate controls have long, straight vibrissae.
The curly hair is progressively more evident until 7-8 weeks of age, when the waved vibrissae and pelage hairs have been replaced by more normal appearing hair. The ocular lesions may be the end result of corneal ulcer formation with subsequent perforation with associated shrinkage of the globe. The ocular lesions varied in severity and numbers of animals affected in all of these studies. More detailed studies are in progress to determine the pathogenesis of ocular lesions in this mutation. No analogous human disease has been compared to the waved-1 mouse mutation.