Humps and muscle loss usually don't change much on a new regimen. If you have extremely high cholesterol and triglyceride that has not responded to lipid-lowering drugs, switching may be your best choice in the long run. That is, if you have something powerful to switch to. You don't say if the current combination was your first. If you have already been on multiple drugs before, you will need to weigh the options carefully.
Liposuction is a reasonable way to deal with the hump, probably the best way.
The wasting of muscle in your extremities is harder to manage, as noted above. Don't put this at risk by switching unless you have a good backup combination. If your doc isn't comfortable or knowledgeable in this area, see a specialist for specific advice about you situation. Experts appearing on this page are independent and are solely responsible for editing and fact-checking their material. Neither The Body nor any sponsor is the publisher or speaker of posted visitors' questions or the experts' material.