If you continue to take d4T after nerve damage shows up, it may become permanent. Lactic acidosis is a buildup of lactic acid in the blood. This is a by-product of abnormal energy production by the cells. It may be caused by damage to the mitochondria. See Fact Sheet 554 for more information on mitochondrial toxicity .
Lactic acidosis can cause severe damage to the pancreas and liver.
Symptoms of lactic acidosis can include weight loss, abdominal pain, and severe fatigue. T is more effective if taken with other antiviral drugs. Pregnant women should not take d4T and ddI at the same time due to an increased risk of lactic acidosis.