This was the first successful cloning of a mammal from a dedifferentiated nucleus. This dedifferentiated nucleus was transplanted into the enucleate egg of another sheep and implanted into the uterus of a third sheep. Since the egg contains mitochondria and mitochondria contain DNA, Dolly actually has two genetic parents, both female. The application of this technology in terms of cloning organs for autologous transplants. In some naturally occurring situations, differentiated cells DNA may dedifferentiate to give rise to other cell types.
Many animals can regenerate lost parts from differentiated cells that remain nearby.
Many plants can regenerate completely from differentiated cells. Plant tissue culture on sterile culture media is now used widely to produce hundreds or thousands of genetic clones of domestic plants 5. In many cases, particularly in animals, differentiated cells do not normally dedifferentiate . For instance, most animals lack the ability to regenerate whole bodies from single isolated cells. Each type of differentiated cell has a particular pattern of expressed genes 1.