Quesnel is easily accessible by road, rail and air. Highway 97 is the major north-south route and also connects Alaska with the lower 48 states of the United States. Highway 26 connects Quesnel with Barkerville to the east while the Nazko and Blackwater Highways serve the western area. Mileage Chart serves the Quesnel area with alternating days of north and southbound passenger travel.
Freight is transported daily.
BC Rail connects with Via Rail and CN Railway in Prince George or Vancouver. Charter bus service is available, also. The Quesnel Airport is located within the city and is open 24 hours a day.