They should have an affordance . That is, a perceived functionality in which the nature of the space helps communicate the content of the worlds within. Each wing should be indicative of the spaces it leads to. The benefit of exploiting six degrees of freedom is that one can make more uses of the space. This goes beyond doing it just because one can.
Landmarks are just as important in wayfinding as is the grid.
We judge our location in space by these landmarks. Sunlight as an orientation device is critical, especially the visual relationship between inside and out. I need to intellectualize the problem a bit more in terms of specific program requirements, to articulate what my givens are and to quantify my decisions in the context of specific constraints and characteristics. Metrics of success of this project could include navigability. The project should be nice, enjoyable.