In California, a large earthquake can generally be associated with a particular fault because we have watched the fault break and offset the ground surface during the earthquake. In contrast, east of the Rockies things are less straightforward, because it is rare for earthquakes to break the ground surface. In particular, east of the Rockies, most known faults and fault lines do not appear to have anything to do with modern earthquakes. We don't know why. We do know that most earthquake locations cannot be measured very accurately east of the Rockies.
Earthquakes typically occur several miles deep within the Earth.
Their locations, including their depths, are usually uncertain by a mile or more. Although the larger faults extend from their fault lines downward deep into the Earth, their locations at earthquake depths are usually wholly unknown. The uncertain underground locations of earthquakes and faults make it terrifically hard to determine whether a particular earthquake occurred on a particular known fault. We also know that there are many faults hidden underground that are large enough to generate damaging earthquakes, but which are also too small to extend from earthquake depths all the way up to ground level where we have the best chance of seeing the faults. These hidden faults are likely to be at least as numerous as the faults we know about.