We are currently investigating the regulation of its synthesis, its effects on eosinophils, and its mechanism of action. Prostaglandins - Prostaglandins act via a variety of receptors, some of which are expressed on eosinophils. PGD2, but not other prostaglandins, acts via this receptor to induce cell migration, actin polymerization, CD11b expression, and L-selectin shedding. Sensitized rats develop early and late airway responses following antigen challenge, similar to those in humans. This is accompanied by increased leukotriene synthesis, both in vivo and by isolated lung.
Glucocorticoids block both airway responses and cysteinyl-leukotriene synthesis.
Courses Biomedical Methods in Medical Research Exp. Xu L, Olivenstein R, Martin JG, Powell WS . J Appl Physiol. Am J Respir Cell Mol Biol. Mirochnitchenko O, Prokopenko O, Palnitkar U, Kister I, Powell WS , Inouye M. Endotoxemia in transgenic mice overexpressing human glutathione peroxidases.