The tears flow frequently and easily. Unhappiness becomes one's mode. And, of course, others then leave. Financial security becomes of little interest. That for which one might have worked with some enthusiasm seems as nothing in the light of lost health.
Hobbies attract no interest.
I have lost all my self-confidence. Fear absorbs me. The unfamiliar frightens me. In some cases the pillars holding up the next level gradual crumble. The person's whole focus is on the basement area.