Sensitivity to mivacurium or other similar agents. Use of multidose vials in clients with allergy to benzyl alcohol. Volatile anesthetics may decrease the dosing requirement and prolong the duration of action. Duration may be prolonged in clients with decreased plasma cholinesterase. Reduced clearance of one or more isomers is observed in clients with end-stage kidney or liver disease.
Geriatric clients show a longer duration of neuromuscular blockade.
Acid-base or serum electrolyte abnormalities may potentiate or antagonize the action of neuromuscular blocking agents. Antagonism of neuromuscular blockade may be delayed in the presence of debilitation, carcinomatosis, and concomitant use of certain broad-spectrum antibiotics, anesthetic agents, and other drugs that enhance neuromuscular blockade. In children 2-12 years of age, mivacurium has a faster onset, shorter duration, and a faster recovery following reversal than adults. The drug has not been studied in children less than 2 years of age. Bronchospasm wheezing, hypoxemia.