Some companies act indifferently to job hunters because of their philosophy that truly interested job seekers will persist. It is not uncommon to hear of applicants being rejected several times before being accepted. It is hard to say. A lot depends on how much you want to work for a given company. If it is a certain job or industry you are after, pursue several companies.
Job hunting is a difficult process.
Reward yourself every time you complete a major task, such as mailing out a number of resumes. Have a strategy. Develop a plan of how you intend to get everything done, including tasks and timelines.