Dosage and administration. Prednesol Tablets are best taken dissolved in water, but they can be swallowed whole without difficulty. Prednisolone is a glucocorticoid that has anti-inflammatory activity. Their synthetic analogues such as prednisolone are primarily used for their potent anti-inflammatory effect in disorders of many organ systems. Prednisolone is about four times as active as hydrocortisone on a weight for weight basis.
Glucocorticoids cause profound and varied metabolic effects.
In addition, they modify the body's immune responses to diverse stimuli. The appropriate individual dose must be determined by trial and error and must be re-evaluated regularly according to activity of the disease. Undesirable effects may be minimised by using the lowest effective dose for the minimum period and by administering the daily requirement as a single morning dose on alternate days. As corticosteroid therapy becomes prolonged and as the dose is increased, the incidence of disabling side effects increases. Frequent patient review is required to appropriately titrate the dose against disease activity.