The disease appears in the 2nd year - always in females. Sporadic occurence with no multi-generational inheritance. Proposed to be an X-linked dominant trait such that no males survive to birth. Cocaine and Heroin Nerve impulses cause release of dopamine from pre synaptic neuron. Dopamine binds to receptor on post synaptic neuron to induce impulse transmission.
Dopamine binds to uptake receptors on pre synaptic neuron for uptake and reuse.
Heroin binds to dopamine receptor on the post synaptic neuron to mimic stimulation by dopamine. This document maintained by Robert J. Huskey Last updated on October 20, 1997.