New Clinical Drug Eval. Review of the literature of nonbenzodiazepine sedatives. Heiligenstein 1998 . Subjective sleep quality improved in all three medication groups, compared to placebo. No effect on sleep time, REM nor self rated sleep quality Schulz 1994 .
Effect is moderate compared with diazepam and chlorpromazine.
Has only weak anti-convulsive properties Leuschner 1993 . Double blind study shows the sesquiterpenes are sedative, without the cytotoxicity of valepotriates Lindahl 1989 . Thompson 1998 . Methods of clinical trial Wassmer 1998 . Kohnen 1988 .