If an accidental overdose occurs, an antidote may be necessary and must be given as early as possible. Other medicines may interfere with methotrexate. They may result in an increase in side effects or a decrease in the effectiveness of methotrexate. Tell your doctor all the medicines you are taking, whether they are prescription or non-prescription medicines. Do not begin or change the dosage of any medicine without first checking with your doctor.
Illness can increase the risk of methotrexate.
Dehydration from fever, significant vomiting, diarrhoea, or decreased fluid intake can be dangerous. Excessive thirst may be a symptom of dehydration. Notify your doctor if these symptoms develop before the next dose of methotrexate. Keep this medicine safely Methotrexate should be kept out of the reach of children. Do not give this medication to other people.