Yes, people do get hired from ads in the newspaper. Always send a cover letter with your resume when responding to an ad. Be sure to tailor the letter so that it addresses each qualification the company is seeking. Instead, take the time to research 10-15 companies that interest you, find out the names of the key managers, and send tailored cover letters and resumes to those companies. Be sure to follow-up with these contacts one week after you mail them your materials.
Employment agencies do receive good jobs.
Register with one or more, making sure any fees are paid by the hiring company. Temping is a good way to learn about companies, earn money during your job search, and make valuable contacts. Not all temporary jobs are clerical in nature. Register with temporary agencies that have more professional-level jobs. Many temporary jobs become permanent full-time.