This pathway can be disrupted by too much dietary intake of saturated fats, alcohol, the catecholamines of stress or by the lack of available cofactors. Excellent sources of GLA include black currant and evening primrose oils. Abrahms in 1965 demonstrated the use of 400 IU of vitamin E effective in the treatment of FBD as well as the relief of many PMS symptom. Vitamin E and Selenium prevent oxidation of EFA, adrenal and sex hormones. Vegetarians have been shown to have markedly increased estrogen excretion, so reducing meats and dairy products is helpful.
Excess weight reduces the clearance of estrogen.
The hyperinsulinism and resultant hypoglycemia associated with PMS make chromium and manganese supplementation important. From a naturopathic and clinical standpoint effective estrogen reduction begins by cleansing the liver where its conjunction for excretion takes place. It also server as an excellent general tonic, alternative and diuretic. Bioflavonoids have anti-histamine activity and inhibit estrogen by competing for receptor sites. A low level of Vitamin D is important for the utilization of calcium.