Hyaline droplets were observed in all dosed male animals but the clinical significance of this lesion cannot be ascertained in terms of human renal effects. Kinkead et al. One group of male rats was treated with the high dose for 90 days followed by a 60-day recovery period to ascertain the reversibility of the testicular toxicity. Toxicological evaluation of data indicated adverse effects on the spleen and testis. The high dose males showed testicular degeneration during the 90-day exposure, which continued through the recovery period.
High confidence is recommended for the study.
The data base contains adequate subchronic studies in rats and mice, reproductive, developmental and chronic studies in rat and lacks additional developmental studies in other species. This assessment was peer reviewed by external scientists. These comments have been evaluated and incorporated in the finalization of this IRIS summary. A record of these comments is included as an appendix to U.S. EPA, 1997. Not available at this time.