Perhaps best of all, the Santiago airport has two minibus companies that will drive you from the airport to any specific address in Santiago for a small, fixed fee. Their booths are located next to the rental car booths. Unfortunately, it does not connect with the airport. But, you can connect to this with the airport bus. The service connects with all national flights.
Fares are low, and service is good.
Reserve seats in Chile. Taxis are an excellent way to get around in most Chilean communities. Upon arriving at the Antofagasta airport, take a taxi to your hotel. There is no airport bus. Chile has many options for car rental, including Hertz and Avis.