Results in enhanced inhibitory action of GABA leading to interference of transmission of nerve impulses in the reticular activating system. Significantly bound to plasma protein.
Elimination is slow because metabolites remain in the blood for several days.
Exceeding the recommended dose may result in development of tolerance and dependence. Is increasingly effective on the second or third night of consecutive use and for one or two nights after the drug is discontinued. Pregnancy or in women wishing to become pregnant. Depression, renal or hepatic disease, chronic pulmonary insufficiency, children under 15 years. Use during lactation may cause sedation and feeding problems in the infant.