Some pass too closely. Nothing new here, but it's still worthy of note. It is advisable to avoid restrooms and rest areas hidden from the Trace at night, especially if traveling alone. Don't leave valuables in locked cars at rest areas, particularly those near urban exits. Cyclists will find most people on the Trace to be friendly and eager to talk.
Harassment is rare.
Water is available at rest stops with restrooms, but a cyclist has to rely on nearby towns for convenience stores. Many towns are quite close-by but still are not conspicuous. No official connection with the Natchez Trace Parkway is implied and none should be inferred.