Treat with carbonic anhydrase inhibitor. It works by in gibiting carbonic anhydrase, the enzyme that catalyzes the reaction batween CO2 and HCO3. Actually works in the kidney to allow loss of HCO3 ion. Na, H2O, and K. Thus, the drug has a diuretic effect and reduces fluid load. This is not so much of a problem with either minocycline or doxycycline.
Iron binds to tetracycline.
If both drugs are required, give them 2-3 hours apart. Birth control pills. Interaction here applies to all antibiotics and wonem of child-bearing age. They are excreted in the bile to the gut. Bugs in the gut hydrolyze the conjugates and free the parent steroid compound which is then reabsorbed.