We are also investigating the molecular machinery responsible for the sorting and targeting of synaptic endosomes to the axonal retrograde transport route. More-over, we are interested in developing novel tools for the manipulation of synaptic terminals and secretory cells. We are focusing on proteins and peptides capable of strongly promoting neurotransmitter release. These agents will be crucial to unravel novel regulatory elements of this pathway. To understand the mechanisms underlying neurotransmitter release and membrane sorting at the synaptic terminal and develop novel specific tools for the dissection of these processes.
Lipid rafts act as specialised domains for tetanus toxin binding and internalisation into neurons.
Osborne SL, Thomas CL, Gschmeissner GS and Schiavo G . Schiavo G and Van Der Goot FG . The bacterial toxin toolkit. Nature Rev. Mol. Iglesias T, Cabrera-Poch N, Mitchell MP, Naven TJP, Rozengurt E and Schiavo G .