The latter dose was employed for the present studies. They were selected for this study with mianserin and mirtazapine. As usual, each was tested once for each dose. Data analysis Data recorded during a test session were lever selection, i.e., the lever on which ten presses were recorded first, and response rates, i.e., the total number of presses on both levers. They were dissolved in sterile water.
Doses are in terms of the base.
Both mirtazapine and mianserin dose-dependently inhibited the DS elicited by citalopram. Further, the data underpin the distinctive mechanism of action of mianserin and mirtazapine as compared to antidepressant agents which modulate monoamine uptake.