Ann Intern Med. Patients receiving dapsone should be tested for glucose-6 phosphate dehydrogenase deficiency.
Inadequate data are available regarding efficacy or safety of atovaquone or clindamycin-primaquine.
TMP-SMZ reduces the frequency of some bacterial infections. Protection against Toxoplasma is provided by the preferred anti- Pneumocystis regiments. Pyrimethamine alone probably provides little, if any, protection. 5 years after the first dose is considered optional. Data are inadequate concerning clinical benefit of these vaccines in this population, although it is logical to assume that those patients who develop antibody responses will derive some protection.