In an artificial gravity system, the ball trajectory is not straight up and down, but curves relative to the observer. The twisting of the free-fall trajectories in artificial gravity reveals the distortion of the gravity itself. Evidently, the comfort zone encompasses a wide range of environments, many of them substantially non-terrestrial. However, we don't know for sure because we haven't put humans into artificial gravity situations and studied the effects. What we do know for sure is that artificial gravity prevents physiological changes associated with zero gravity.
Humans adapt very well to space.
However, there's a lot we don't know about the long term effects of weightlessness on humans. We can, however, eliminate that concern entirely by using artificial gravity with rotating space habitats. It is ironic that, having gone to great expense to escape Earth gravity, it may be necessary to incur the additional expense of simulating gravity in orbit. Before opting for artificial gravity, it is worth reviewing the consequences of long-term exposure to weightlessness. In response, it activates excretory mechanisms.