The presynaptic neurons are the ones that are affected with Parkinson s disease and nobody knows why people develop Parkinson s disease. Nobody knows why people develop idiopathic Parkinson s disease. Reglan, reserpine, Aldomet. It happens commonly, don t respond well to medicines though. Toxin induced parkinsonism is rare too.
Excess copper can do it.
There was an MTPT toxin. The most common is Shy-Drager s syndrome where a person has a few characteristics. This is The next most common would be progressive supranuclear palsy. These people are invariably diagnosed with Parkinson s disease but at some point, usually in the first few years, they begin to develop extraocular gaze palsy. We ve talked about those four cardinal symptoms and levodopa helps all those things.