African Burkitt's lymphoma is always associated with EBV infection. Nasopharyngeal carcinoma Malignant tumour of the squamous epithelium of the nasopharynx. Very common in Southern China. Detectable HHV8 in early KS lesions consistent with a causal role for the virus. Results of serological studies.
Lesions commonly precede development of opportunistic infections.
A recently identified human herpesvirus has been implicated in the pathogenesis. A clinical diagnosis may be sufficent but when required a virus-specific diagnosis can be made. Infections in immunosuppressed patients. Nucleoside analogue - inhibits viral DNA synthesis. Prodrug - requires viral thymidine kinase for activation.