If client is at poor risk, including depressed bone marrow function, nutritionally poor, or potentially serious infections. Do not use during pregnancy unless benefits clearly outweigh risks. Esophagopharyngitis, myocardial ischemia, angina, acute cerebellar syndrome, photophobia, lacrimation, decreased vision. Complications of intra-arterial administration are arterial aneurysm, arterial ischemia, arterial thrombosis, bleeding at catheter site, occluded, displaced, or leaking catheters, embolism, fibromyositis, infection at catheter site, thrombophlebitis. Serum transaminase and bilirubin, LDH, alkaline phosphatase.
Infusion is continued as long as a response continues.