Splenic sequestration occurs at any age in individuals with the other sickle syndromes. In all sickle syndromes, sequestration may be seen primarily in the liver in older individuals.
Episodes tend to be recurrent so many advocate splenectomy or chronic transfusion.
General guidelines suggesting a need for evaluation include. Clinical Findings Subjective Data Present Illness . Patient may be asymptomatic or have symptoms of acute lethargy, loss of appetite, increased weakness, fatigue, or dyspnea on exertion. History of recent infections, change in jaundice, increased pallor, increase in abdominal girth, bruising, petechiae, change in urine color, dizziness, syncope, and present medications. Review of symptoms .