Consideration of the symptoms, molecular nature, current treatment, and amelioration by gene therapy of diseases caused by gene and protein defects. A comprehensive examination of the role of carbohydrates, lipids, proteins, vitamins, and minerals in maintaining good health, as well as our current understanding of the interplay between nutrition and disease. An examination of the basic anatomy, chemistry, and physiology of neural systems. The organization of the brain and its role in behavior and in disease states are presented in an interdisciplinary way. Mechanisms of pathogenesis and pathophysiological consequences in diseases already well-understood at a biochemical level.
Emphasis is placed on the logic behind existing and future drug therapies in disease.
This course emphasizes the development of methods for immunotherapeutic intervention in cancer and autoimmune and infectious disease. A study of the effects on plant predators of secondary metabolites in plants as a basis for the novel development of therapeutics. A survey of novel macromolecular targeting approaches to drug design in important human disorders. A survey of novel approaches to drug design and development. The biochemical principles underlying toxicological phenomena, including biotransformation, host and environmental modulation, and target organs.