Due to abnormal renal function, there is accumulation of glucophage which results in prolonged plasma and blood half life.
Lactic acidosis is rare but serious metabolic complication that can occur.
Renal function does affect he side effects as shown from reported cases. The doctor should monitor the patient s renal function when the patient becomes elderly. Yes, take with meals. If blood sugar levels drop low in patient, the diabetic can start to choke and go into seizures. It s pertinent to raise blood sugar by eating something sugary.