Thus mild MS is a vastly underestimated disease. The diagnosis of MS is usually not difficult. That is better than any laboratory test. The problems with diagnosis occur when one or more of the factors are not present. Then the percentage drops quickly.
Laboratory studies are then very helpful.
The neurological exam may be extended through the use of computers. Responses in the nervous system can be stimulated by evoking them electrically and measuring them with a computer. These are called evoked responses. Those may show that there is more than one abnormality in the nervous system. The spinal fluid may be examined looking for an increase in particular proteins.