Rats were sacrificed four weeks after treatment, and the number of spermatids in each left testis was ascertained. The right testes were examined via stereology for germ and Leydig cells. This study suggests that TCDD-induced androgen deficiency may be related to a reduced Leydig cell volume, but that the reserve capacity of the Leydig cells and the remaining level of testosterone is sufficient to maintain spermatogenesis. Chahoud et al . Germ cells were altered at all developmental stages evaluated.
Endometriosis is a major cause of fertility problems in women.
In addition, erythropoiesis appeared to be inhibited as evidenced by a reduction in the number of erythroid cells in fetal liver. In contrast, in both males and females of the F1 generation from the high-dose F0 females, reproductive success was severely impaired, especially as regards pregnancy rates. Rather than the expected reduction in this effect if F1 mating were delayed 12 months, pregnancies actually fell to zero. Mayura, Spainhour et al . Seven articles were concerned with the developmental toxicology of phenoxy herbicides themselves, rather than dioxins.