Ferrets with an unknown vaccination history of any age will need two shots three weeks apart, and then a yearly booster shot. Keeping your ferrets indoors and away from other animals will not protect them. One vaccination at 14-16 weeks, then a yearly booster shot. Ferrets do not need to vaccinated for feline distemper or parvo. They don't need a 5-way dog vaccine.
Ferrets do occasionally have adverse reactions to vaccines.
These are rare, but life-threatening. We recommend waiting at least 15 minutes at the vets afterwards, and having 2 to 4 weeks in between the distemper shot and the rabies shot to lessen the chance of a reaction. A ferret which has been well treated and bred to be a pet should not bite or be vicious, but ferret play does include mock combat, and kits won't know how hard they can put their teeth on you without hurting you. Just remember, ferrets are not malicious, they just need to learn what behavior is acceptable. Nose flicking is instinctive, but the ferret will learn to associate your hand with pain and you want to avoid that.