Pregnancy C - Safety for use during pregnancy has not been established. Somewhat protective against lethal doses of amatoxin. Some recommend a water-soluble preparation of silymarin, which inhibits penetration of amatoxins into liver cells. Interactions May decrease effectiveness of oral contraceptives Pregnancy C - Safety for use during pregnancy has not been established. Consider transfer of any patient with progressive hepatic dysfunction to a facility that has a liver transplant service.
Liver failure is the most serious complication of amatoxin ingestion.
Hepatic coma and hypoglycemia can complicate liver failure. Progressive hepatic failure can lead to hepatorenal syndrome. With good supportive care, mortality rates are now lower than in the past. Liver transplant can save the life of a patient with the most severe amatoxin poisoning. Treatment of human amatoxin mushroom poisoning.