Although a muscle biopsy can be performed at any medical center, very few centers have the ability to do all the testing necessary to make a diagnosis. Therefore, the physician must be very conscientious in planning before the biopsy is done. Muscle Biopsy Muscle tissue can be used for tests that can be diagnostic, even when the above tests are normal. References labs should be contacted before the biopsy is done so that preparation of the muscle is done correctly. Experts disagree on whether complex I activity can be appropriately measured in muscle mitochondria.
Experts disagree on whether analysis of frozen muscle tissue is usually or ever helpful.
ETC activity give a good approximation of the catalytic activity of the measured enzyme complexes but does not tell anything about mitochondrial membrane function or substrate transport. This can be run on mitochondria isolated from fresh muscle only. Use of this website implies that the user acknowledges and agrees to abide by the Terms Of Use . The materials on this Website may be protected under U.S. copyright law and international treaty.