In the larynx, a conservative approach has been recommended consisting of local excision using laser or microlaryngeal instruments with conservation of surrounding tissue. Recent literature has advocated CO2 laser as the treatment of choice. Recurrence is rare, and, if it occurs, can be treated with further conservative excision. Partial glossectomy for macroglossia represents localized surgery for a systemic disease. Results of partial glossectomy have been mixed but are generally favorable.
Goals are to restore speech and swallowing, decrease sialorrhea, and improve cosmetic appearance.
Prognosis in patients with systemic amyloidosis is poor. Almost all patients with light chain disease are dead within three years of diagnosis. The median survival after diagnosis is between four and 15 months. The most common causes of death are renal and cardiac failure. Biopsy of these lesions revealed amyloidosis.