Moderate poisoning leads to respiratory depression and hyporeflexia. Severe poisoning leads to flaccid, areflexic coma, apnea, and hypotension. Occasionally, hyperreflexia, rigidity, clonus and Babinski signs are present. Miosis is common, but mydriasis may be present with certain agents. The non-barbiturates, such as methyprylon and glutethimide more commonly present with mydriasis.
Hypotension is usually secondary to venodilation and negative cardiac inotropic effects.
Resembles barbiturate poisoning. It can lead to severe muscular hypertonicity and seizures. Cerebellar incoordination Severe gastritis and GI bleed. CNS depression with cardiopulmonary collapse. Associated with hepatitis, gastritis, proteinuria and dysrhythmias.