Potentiation of otthostatic hypotension may occur. Dosage adjustment of the antidiabetic drug may be required. Intensified electrolyte depletion, particularly hypokalemia. Possible decreased response to pressor amines but not sufficient to preclude their use. Possible increased responsiveness to the muscle relaxant.
Diuretic agents reduce the renal clearance of lithium and add a high risk of lithium toxicity.
Refer to the package insert for lithium preparations before use of such preparations with chlorothiazide.