Heterozygous mice have a kinky tail, white feet, and a white spot at the ventral midline.
This neurological phenotype is associated with a unilateral or bilateral atrophy of the optic nerves. Harris et al. Collectively, these studies place the Bst locus 25 to 42 cM distal to the centromere and proximal to Sod1. Given the marked phenotypic similarity of retinal phenotypes between OPA1 and Bst and the chromosomal homology, we have generated a higher resolution map of Bst on Chr 16 using an intraspecific backcross. These progeny were phenotyped for Bst by inspecting the tail for kinks and the belly for white hairs.