Apocrine glands play no part in thermoregulation. Eccrine glands are found over nearly the entire body surface and are especially dense on the palms and soles of the feet. Their secretions contain urea and lactic acid. They are supplied with cholinergic fibers controlled in part by sympathetic innervation. Emotional or thermal stimulation and repetitive activities are the common stimulants for over production.
Hyperhidrosis is more common in teens and younger adults and frequently resolves spontaneously.
In more severe or refactory cases, cervical sympathectomy produces good control of symptoms. Chemotherapy has no role. Current Therapy in Vascular Surgery, ed 2. Causalgia, hyperhidrosis, and frostbite are the indications with the highest prediction of success. Transient relief of symptoms with a stellate ganglion block is a good predictor of results for surgical sympathectomy.