Possesses anti-inflammatory, antipyretic, and analgesic properties. Known to inhibit both prostaglandin and leukotriene synthesis, to have antibradykinin activity, and to stabilize lysosomal membranes. Approximately 5 hr. Analgesic for mild to moderate pain. Temporary relief of aches and pains associated with the common cold, toothache, headache, muscle aches, backache, menstrual cramps, reduction of fever, and minor pain of arthritis.
Juvenile rheumatoid arthritis, sunburn, prophylaxis of migraine, migraine due to menses.
Use of the extended-release product for acute pain in any client or for initial therapy in clients who are small, elderly, or who have renal or hepatic impairment. Geriatric clients may manifest increased and prolonged serum levels due to decreased protein binding and clearance. Use with caution in clients with a history of GI tract disorders, in fluid retention, hypertension, and heart failure. Peptic ulcer, GI bleeding dyspepsia, nausea, diarrhea, constipation, abdominal pain, flatulence, anorexia, vomiting, stomatitis. Peripheral edema, fluid retention.