Most of the trials were published before the 1990s, though some were published as recently as 1999. About a third were published in journals with impact factors of 7 or more, so they were by no means all published in obscure places. The best clinical areas for reporting the number and reason for adverse event discontinuations were antibiotics for acute sinusitis, and arthritis. 63 25-100 Range refers to the limits found in each of seven clinical areas. This business of adverse event reporting is both difficult and important.
Harm can be common, mild, and reversible.
It could be rare, major and irreversible. Individuals will view their importance differently. A flautist may view with dismay a treatment causing dry mouth, while others of us will simply drink more. A man or woman in their 30s with a family depending on them will think differently about a risk of death of 1 in 1000 than will a single person in their 70s, even if the benefit is the same. Truly one man's meat is another man's poison.