The remote possibility of pancreatitis should be considered when epigastric pain or unexplained gastrointestinal symptoms develop after prolonged administration. Cases of accidental overdosage have shown skin pallor, bradycardia, pronounced hypotension, dryness of the mouth, vomiting and deep sedation or coma. Gastric lavage and the administration of an analeptic and a vasopressor have produced complete recovery within 24 hours. Coma may ensue. There is no specific antidote.
Gastric lavage is recommended, followed by supportive treatment.
It is important to monitor serum electrolytes carefully. When necessary, i.v. dextrose-saline with potassium may be administered with caution. Supplemental clonidine may be given if necessary. Give the last dose of the day immediately before retiring to ensure blood pressure control during sleep. When diuretics alone are ineffective or insufficiently effective, Combipres at the recommended dose may be given after withdrawal of the diuretic.