This Javascript code is not necessary to use the site. Fanconi syndrome is an impairment in proximal tubular function of the kidney. This impairment causes certain compounds, which should be absorbed back into the bloodstream by the kidneys, to be excreted in the urine instead. Some compounds that may be lost in the urine include glucose, amino acids , uric acid, and phosphate. Another problem that may result is dehydration caused by excess urination.
Fanconi syndrome can be genetic or acquired later in life.
Cystinosis is the most common cause of Fanconi syndrome in children. Another genetic defect that can cause Fanconi syndrome is Wilson s disease, which causes copper to collect in the kidneys, liver, eyes, and other organs. Similarly, exposure to heavy metals, such as lead poisoning, can cause Fanconi syndrome, even when there is no genetic disease. In adults, Fanconi syndrome can be caused by various acquired disorders that damage the tubules of the kidneys. As in children, this damage can be caused by exposure to heavy metals such as lead, mercury, and cadmium.