That's a function of how much is circulating in the bloodstream, and how fast the cells are being remodeled. Some cells, which are quicker, pick up the omega-3 fatty acids faster. Intestinal cells, for example, take about two weeks from feeding before omega-3s show up. It's thought that skin cells take 6 to 8 weeks. Let's take a look at what goes on when skin gets inflamed.
Inflammation is a cell's response to some kind of insult, either physical or chemical.
The insult could be a scrape or a reaction to something like a mosquito bite or flea bite. Inflammation is simply the cell's defense mechanism. One of the cell's reactions is to produce compounds that attempt to protect it and some of its neighbors. Those compounds are made from fatty acids and are called eicosanoids. The eicosanoids that are made from omega-6s attract many white blood cells to the site, and produce much of the pain and itching associated with the mosquito bite.