Regio-specific toxicity in organ culture. Species comparison in vitro toxicity. Human in vitro toxicity studies. Organ specific toxicities studied presently in brain, heart, lung, kidney and liver. Pyrrolizidine alkaloid-induced depletion of taurine from rat liver in vivo and in vitro .
Liver slices as a model in drug metabolism.
Human and rat lung biotransformation of cyclosporin A and its derivatives using slices and bronchial epithelial cells. Sulindac sulfone inhibits azoxymethane-induced colon carcinogenesis in rats without reducing prostaglandin levels. Protein arylation precedes acetaminophen toxicity in a dynamic organ slice culture of mouse kidney. Vitamin A potentiation of vinylidene chloride hepatotoxicity in rats and precision-cut rat liver slices. Biotransformation of a somatostatin analogue in precision-cut liver and kidney slices from rat, dog and man.