To have an integrative view on the coronary flow regulation, these basic information are reconstructed using mathematical model and computer simulation technology. This research provides a basic foundation critical to our understanding of blood flow regulation in the coronary microvascular network under normal and disease states. Adenosine potentiates flow-induced dilation of coronary arterioles by activating KATP channels in endothelium. Ishizaka H, SR Gudi, JA Frangos and L Kuo. Liao JC, TW Hein, MW Vaughn, K-T Huang, and L Kuo.
Intravascular flow decreases erythrocyte consumption of nitric oxide.
Hein TW and L Kuo. Hein TW, JC Liao, and L Kuo. Vaughn, MW, K-T Huang, L Kuo and JC Liao. Erythrocytes possess an intrinsic barrier to nitric oxide consumption.