Using microarrays, we have identified molecular pathways that may be involved in astrocyte reactivation in response to pressure that are promising targets to test in the future. Transforming growth factor- b isoforms in human optic nerve heads. Differential expression of cell adhesion molecule isoforms in normal and glaucomatous optic nerve heads. Responses of different cell lines from ocular tissues to elevated hydrostatic pressure. Synthesis of elastin associated microfibrils by human optic nerve astrocytes in vivo and in vitro.
Hydrostatic pressure stimulates synthesis of elastin in cultured optic nerve astrocytes.
Expression of metalloproteinases and tissue inhibitors of metalloproteinases in human optic nerve head astrocytes. Induction of HLA-DR expression in human lamina cribrosa astrocytes by cytokines and simulated ischemia. In vitro evaluation of reactive astrocyte migration, a component of tissue remodeling in glaucomatous optic nerve head. Increased elastin expression in astrocytes of the lamina cribrosa in response to elevated intraocular pressure.