Have resuscitation equipment and Flumazenil for reversal available. Clinical Oncological Society of Australia. Vesicant drugs should be injected into the side arm of a fast running drip, with frequent drawing back of the syringe, to check for the free return of blood up the tubing. Cannulas used for vesicant drugs should be freshly placed at a secure site. Where possible, avoid giving vesicant drugs into cannulas placed in the elbow, wrist and back of hand.
Extravasation is at greater risk of causing extensive damage of nerves and tendons.
Give cyclophosphamide in the morning, because of its potential for haemorrhagic cystitis and late onset bladder cancer. When giving IVI, give extra fluid. Advise patient to drink copious oral fluids, and to void frequently. Lasix may be given with fluids to produce a diuresis. Allopurinol All patients commencing chemotherapy should be covered with allopurinol to avoid hyperuricaemia.