No medications are known to improve the course of the disease, which usually is benign and limited. Symptomatic treatment can be given. Isolate clinically infected animals from contact with humans who have not had previous exposure. Animals will have typical lesions of circinate or horseshoe-shaped crusted erosions around the moist surfaces of the mouth and nose, or papules and erosions around the teats. They also may have alopecia of lesions on hair-bearing surfaces.
Lesions can be recurrent or chronic in cows.
Various reports caution against the possibility of bacterial superinfection, though our literature search did not turn up any reported cases. Reports exist of generalized exanthem, erythema multiforme, or bullous erythema multiforme following infection with milker's nodule. One case reported spontaneous resolution of exanthem at one week. Because milker's nodule is relatively benign, precautions against overtreatment may be more applicable. Electron microscopy for the rapid diagnosis of pseudocowpox and Milker's nodule.