However, because drugs that bind COX come from a variety of chemical classes they may vary in selectivity for the two known isoenzymes of COX and individual drugs possess a wide variety of additional activities that may or may not be important to control of pain and inflammation in a particular patient. When special studies of and individual patient is carried out however, it appears that one drug may be superior to another for THAT patient. This is in stark contrast to the veterinary approach to these drugs that would suggest certain anti-inflammatories are superior in a general way for particular kinds of inflammation or pain in a general population. Finally, because these drugs come from such a wide range of chemical classes and most are metabolized extensively, it is difficult if not impossible to extrapolate doses and clinical expectations from man to animals or between animal species. Theoretically, the drug is carried to the site of inflammation on albumin.
Higher doses are more analgesic but can only be used for short durations.
Higher doses are more analgesic but can only be used for short durations. Carprofen and etodolac appear to be the safest. Coagulation - a desirable effect in some situations but can be a problem. Effect is marked even at low doses. This effect with carprofen should not have been a surprise.