Other lectures and poster presentations also suggested that lipoic acid reduces oxidative stress in the mitochondria of the heart muscle, and raises the levels of ascorbate and glutathione in the heart and liver mitochondria. It is probably by increasing mitochondrial energy output that lipoic acid is able to lower blood glucose levels and the formation of harmful glycation products. Lipoic acid is thus emerging as an extremely important anti-aging agent. Interestingly, the lower dose was more effective than the higher dose. Rasagiline does not seem to offer any advantages over deprenyl, a drug used by some anti-aging researchers.
Dosage is obviously crucial.
Estrogen replacement in postmenopausal women has also been shown to help prevent Alzheimer's disease . In fact, like many other phenolic compounds, estrogens are potent antioxidants. A sufficient dose of estrogen can totally prevent lipid peroxidation in brain cell membranes. However, like most antioxidants, estrogens need to be recycled back to their antioxidant state, or else they can act as pro-oxidants. Here glutathione appears to play a critical role.