First generation cephalosporin useful against most gram-positive cocci.
Some Streptococci, many Klebsiella, Enterobacter, and Hemophilus influenzae, most Proteus vulgaris, nearly all Pseudomonas species are resistant. Give IV over 15-30 minutes. Action Inhibits synthesis of bacterial cell wall. Chemically closely related to penicillins, but not degraded by beta-lactamases. Resistance is based on cephalosporinase production.