This process has been referred to as trans-signaling. The mechanism of action of soluble membrane receptors is not understood. Moreover in our hands, IL-6 levels are not altered in CSF of AD patients, a finding which is still controversial. Expression of functional trk tyrosine kinase receptors following T cell activation. Neurotrophins and cytokines - intermediaries between the immune and nervous system.
Inflammatory signals induce neurotrophin expression in human microglial cells.
Complement protein C3a induces neurotrophin expression in human microglial cells. Neural Notes , Vol. Decreased trkA neurotrophin receptor expression in the parietal cortex of patients with Alzheimer's disease. Sympathetic neurons can produce and respond to interleukin-6. Neuronal activities of IL-6 type cytokines often depend on soluble cytokine receptors.