No mortality is associated with peripheral giant cell granuloma, and the lesion has minimal morbidity. Malignant transformation has never been reported. No known racial predilection is associated with peripheral giant cell granuloma. The mean age of patients at the time of diagnosis typically is 38-42 years. Peripheral giant cell granuloma has a relatively rapid growth rate, often attaining a size of 1 cm within a few months.
Lesions generally are asymptomatic.
Most lesions are less than 1.5 cm in diameter, though infrequently, peripheral giant cell granuloma may grow as large as 5 cm in greatest dimension. A slight predilection for the mandible is observed in most reported series. Surface ulceration often is present. Periapical radiographs typically demonstrate a cupping out or saucerization of the alveolar bone that underlies peripheral giant cell granuloma. Intact or ulcerated surface epithelium covers peripheral giant cell granulomas.