Large doses of penicillamine cause a vitamin B1 deficiency. Desferal binds to heme iron therefore inactivating it. Pralidoxime will only work in the treatment of organophosphorous compounds after 24 hours. CO displaces O2 on Hb and also keeps other O2 molecules from dissociating from the Hb Organochlorine is water-soluble so is easily excreted. Neurotoxicants decrease electrical excitability in a dose-dependent way.
Lead causes toxicity if inhaled.
Penicillamine can generate H2O2 when converted to a free radical by peroxidase.