In the rare case, metastatic disease to the lungs may occur. This is confusing since the tumor is considered benign. There is no way to differentiate between the giant cell tumor that will metastasize and the one that won't. Chemotherapy is not of use. Radiation therapy is used in only unresectable lesions.
Fibrous dysplasia is a hamartoma of bone.
The pathognomonic feature is that the bone is being laid down directly by the fibrous stroma rather than by rimming osteoblasts. The patients with this condition often have pathologic fracture and develop bowing and other skeletal deformities. Albright's Syndrome is one severe form of this disease in which the patients have precocious puberty, cafe au lait spots, and fibrous dysplasia. X-ray findings in fibrous dysplasia reveal a lytic lesion with ground glass appearance inside the lesion. This is due to the combination of small segments of woven bone inside a fibrous stroma.