M edications are useful in managing inflammation associated with rheumatoid arthritis. The first compounds employed are either salicylates or other nonsteroidal anti-inflammatory drugs. These medications exert their anti-inflammatory action by modifying prostaglandin metabolism. They are used as initial therapies. All share common toxicities including stomach upset, liver function abnormality, renal dysfunction and fluid retention.
Gold is a remittive agent that can prevent disease progression.
It is generally given by injection but can be taken orally. It has some common toxicities including skin and mucous membrane problems. C areful monitoring of gold therapy is very important in patients with rheumatoid arthritis. During the duration of the therapy complete blood counts, platelet counts and urinalyses must be done at the time of each injection. After a prolonged period of time without toxicity monitoring may be done every other injection.