None of the above. This pattern of resistance to aminoglycosides is highly unlikely. A patient is suffering from hepatic coma. 8 th cranial nerve damage resulting in hearing loss. Doxycycline is unaffected by antacids, tetracycline is inactivated by antacids.
Doxycycline requires less frequent dosing and lower doses than does tetracycline.
Dirithromycin is a prodrug which spontaneously converts to the active drug, as shown in the scheme above. The development of MLS resistance confers resistance to clindamycin. The development of MLS resistance confers resistance to streptomycin. Chloramphenicol toxicity can result from inability of the newborn to excrete the drug. Synercide is a streptogramin which consists of a synergistic mixture of quinupristin and dalfopristin.