So a network that is twice as large will be four times as valuable because there are four times as many things that can be done due to the larger number of interconnections. Conversely, a network of information that is subdivided into disconnectd units is less useful. Interconnected information is very useful. Its much easier to link to relevant information rather than having to gather, organize, and present it yourself. In the same way, others will want to be able to link to information within your site.
Frames makes such interconnections more difficult.
Accessibility A frames layout is inherently problematic for someone using a braille or audio browser. The frames design shows multiple page views simultaneously, no problem for a person viewing the page, while audio and braille browsers read a page linearly, one word at a time. Where there are interactions between frames, such as clicking on an item in one to cause change in another, the interaction is simply not do-able with such browsers. Another type of browser used by visually impaired persons enlarges a page enormously, allowing a page to be read at any magnification up to one character at a time. Navigating a frames design at high magnification is difficult.