You'll need the time to get accustomed to the semi-frustrating button assignments. With enough practice though, you'll have them down pat. It's good for anyone who doesn't want to take time time to learn all of the keypresses, but if you plan on getting hooked on the game, learn the traditional control method. You'll feel better in the long run. Another reason to use one-button control is if more than one gamer wants to play on the same computer.
Fumbles are rare, but appear during bad weather, and strike CPU and human equally.
Don't try sitting in the pocket to improve your QB's reads. Sacks are way too plentiful. It has to be a gameplay consideration, so take it as a small blessing and run with it. You will have to have a good rushing attack in order to open up the defense to the pass. As good as the defensive AI seems to be, offensive playcalling doesn't appear to be that intelligent.