For those afflicted with the illness, it is extremely distressing and disruptive. Despite vigorous research efforts, a specific genetic defect associated with the disease has not yet been detected. It may be helpful to think of the various mood states in manic-depressive illness as a spectrum or continuous range. In the other extreme, mania may be the main problem and depression may occur only infrequently. Sensuality is pervasive, the desire to seduce and be seduced is irresistible.
Infectious humor ceases to amuse.
Recognition of the various mood states is essential so that the person who has manic-depressive illness can obtain effective treatment and avoid the harmful consequences of the disease, which include destruction of personal relationships, loss of employment, and suicide. Manic-Depressive Illness Is Often Not Recognized by the Patient, Relatives, Friends, or Even Physicians. Thus, even when family and friends learn to recognize the mood swings, the individual often will deny that anything is wrong. For example, it may first appear as alcohol or drug abuse, or poor school or work performance. If left untreated, bipolar disorder tends to worsen, and the person experiences episodes of full-fledged mania and clinical depression.