For this kind of understanding, this book will have to studied. We will have to design experiments to prove the pathway of information transfer proposed in the Thermal Protein-First Paradigm. We need to know the appropriate methods to use in such studies. We must keep these things in mind as we go. Lets do it.
Lets jump into it while excited.
The author defines three kinds of genes. In prokaryotic cells, we know of DNA-dependent RNA polymerase. Also, the universal genetic code, mutations, crossing-over, gene conversion, deletions, insertions, and hotspots are reviewed . Also, changes must occur from no regulation of information expression in thermal proteins to coordination of DNAomes in advanced metaprotocells. There we read that a progenote gives rise to a cenancestor that gives rise to prokaryotes in Domains Archaea and Bacteria.