Colors and Contrast Care should be taken to avoid using color combinations that can be difficult to read for persons with color deficit vision. Also, avoid noisy backgrounds that detract from the readability of the page. If possible, set your monitor to display in grayscale and review the site. If a normally sighted person can't easily make out the text, consider revising your choices. The bottom line for any publication is proofreading.
Good design takes time.
Skimping on accessibility issues will only limit the audience of your web site. Automated tools can help identify issues with pages, and are a good starting point for making your site accessible. Note, however, that current automated tools can't catch everything. Test your site using a screen reader. View it on all possible platforms in all possible browsers.