Biosynthesis and turnover of the mannose 6-phosphate receptor in cultured Chinese hamster ovary cells. Mechanism for selective secretion of a lysosomal protease by transformed mouse fibroblasts. J. Cell Biol. The proregion of cathepsin L is required for proper folding, stability and ER exit. Lysine is a common determinant for mannose phosphorylation of lysosomal proteins.
L is the recognition site for mannose phosphorylation.