Zotepine has a concentration dependent effect on serum prolactin levels - at high elevels in stimulates prolactin secretion and at low cocentratiions it has an inhibitory effect. Cytochrome P450 is probably involved in metabolism. A substituted dibenzothiepine tricyclic agent. Improvements in EPMS and AIMS were also significant. There is some evidence that zotepine is useful in treatment resistant schizophrenia.
High doses can lower the epileptic threshold.
This weight gain compares badly with that of typical antipsychotics. Constipation, asthenia, dry mouth, akathisia, EPS and lab abnormalities such as increases in AST, ALT, and GGT also occurred in a significant minority. Uric acid levels may decrease. Interactions Co-administration of benzodiazepines results in higher serum concentrations. of zotepine. In vitro data suggests a low potential for interactions with imipramine, prcyclidine, norfluoxetine and ketoconazole.