These regulatory agencies and others have also provided guidance for the conduct of various types of toxicity studies.
Guinea pigs are the preferred species used in the skin sensitization test.
These guinea pigs will be given multiple dose administrations over a period of 2 to 4 weeks first and then after another 2 to 3 weeks later, a nonirritating dose for challenge of sensitization. Immunotoxicity studies are those in which the cellular, humoral, and other toxic effects on this system are investigated. Skin tests for antibody-mediated responses and for delayed hypersensitivity are used to assess overall immunocompetance.