Trescowthick Research Laboratories, Peter MacCallum Cancer Institute, St. Andrew's Place, East Melbourne, VIC 3002, Australia. C-terminal truncations of the protein that include the RING finger render it oncogenic. However, D-cbl is still capable of binding to the Drosophila EGF receptor. We have isolated a small deletion that encompasses the D-cbl transcribed region. The mutation is homozygous embryonic lethal.
Heterozygotes exhibit a low penetrance of ectopic wing veins.