Discussions will expand on the basic principles of carcinogenesis as they apply to the latest advances in the field. This course will examine the biochemical and molecular mechanisms of natural and synthetic cancer chemopreventive agents. Independent laboratory research for fulfilling dissertation requirements. Literature and research reports by students and staff. Literature and research reports by students and staff.
Emphasis is placed on measuring drug-protein interaction.
Analysis of experimental design, calculation of sample data, and applications such as radio-immunoassays will be considered. Biochemical mechanisms underlying drug actions and reactions including toxicologic effects of drugs will be covered, with emphasis on molecular mechanisms involving drug receptor interaction, the actions of drugs and hormones on regulatory mechanisms in various disease states. Factors affecting the absorption, distribution, metabolism, and excretion of drugs will be discussed in terms of environmental, biochemical, and physiochemical parameters. Pertinent literature will be reviewed and special problems discussed. This course examines the cellular mechanisms that mediate xenobiotic toxicity at the cellular, biochemical and molecular level.