The transfered genes will be in environments different from their normal environment and the positions of integration of the genes in different cell lines will differ. A variation of the liposome technique is the fusion of two cells. When this occurs between bacterial spheroplasts carrying plasmids and eukaryotic cells, the plasmids are often transferred into the eukaryotic cell environment and function there. When two eukaryotic cells are used, somatic hybrids are the result. In another variation, cationic lipids that interact with DNA can deliver that DNA to cells.
Liposomes are but one way of putting DNA into living cells.