Analysis of ingested drinking water revealed fluoride concentrations of 0.49 - 11.36 ppm. Histopathological studies revealed non-specific lesions. Stool examination revealed ova of Ascaris lumbricoides in two NUD patients, while the rest had normal stool on examination. Jejunal aspirates were negative for Giardia lamblia in all the subjects. Scanning electron microscopic studies revealed widespread damage to the mucosa, viz.
Gastrointestinal discomfort can be an early warning sign of fluorosis.
Fluoride toxicity should be considered a possible reason for non-ulcer dyspepsia, especially in fluorosis endemic areas. Gastrointestinal discomfort in the form of dyspeptic symptoms should be an important diagnostic feature when identifying fluorosis patients and should not be dismissed as non-specific.