Please conduct a current literature search and check the appropriate current online database for the most recent quantitative information. Acrylamide is considered to be a potent neurotoxin at low levels of exposure. Animal studies have reported developmental and reproductive effects from oral exposure to acrylamide.
Human data are inadequate on acrylamide and cancer risk.
In rats orally exposed to acrylamide, significantly increased incidences of tumors at multiple sites have been observed. These include mammary tumors, central nervous system tumors, thyroid follicular tumors, and uterine adenocarcinoma in female rats and thyroid follicular tumors and scrotal mesothelioma in males. Exceedance of the RfD does not imply that an adverse health effect would necessarily occur. As the amount and frequency of exposures exceeding the RfD increase, the probability of adverse health effects also increases. The general public may be exposed to acrylamide through contaminated drinking water.