Some evidence of adverse effects on reproduction was observed both in humans and rodents. Ethylene dibromide is mutagenic in bacteria and Drosophila , and in rodent and human cells in vitro . It induced DNA breakage but not chromosomal aberrations or micronuclei in vivo in rodents. It gave negative results in dominant lethal tests in mice and rats. It did not induce either chromosomal aberrations or sister chromatid exchange in humans in vivo .
Ethylene dibromide binds to DNA in vitro and in vivo in rodents.
There is inadequate evidence in humans for the carcinogenicity of ethylene dibromide. There is sufficient evidence in experimental animals for the carcinogenicity of ethylene dibromide. For definition of the italicized terms, see Preamble Evaluation .