Dryness of the skin and mucous membranes occurs, as does minor headache. These are normal mechanisms of high altitude adaptation. The symptoms typically develop within 36 hours at altitude. Trekkers suffering from HACE are unable to walk a straight line, become disoriented, and can lapse into a coma if not given proper medical treatment. Left untreated, HAPE can lead to death in the most severe cases.
Gradual ascent is crucial.
Start your journey below 10,000 feet and increase altitude by a maximum of 1,000 feet per day. Take a rest day every 3,000 feet attained. Trek more than 1,000 feet per day, as long as you return to sleep at a lower altitude. Work on your physical conditioning before your trip. Follow all the normal safe-travel tips.