For multiple administrations it would be advisable to fashion a mouth speculum out of Plexiglas. 12 Rabbits should be placed in a restraining device before attempting this procedure to avoid unnecessary struggling and injury. Care should be taken to smooth the edges of the cut syringe case to avoid damaging the oral mucosa. For the chronic administration of compounds placement of a pharyngostomy tube may be advisable. Sites used for collection of blood from veins may also be used for intravenous administration.
Intraperitoneal administration is one of the most frequently-used parenteral routes in rodents.
Other locations are the musculature and subcutis. Absorption by this route is more rapid than from subcutaneous administration. Regardless of the route used, it is essential that the subject be securely restrained to prevent unnecessary struggling by the animal and to avoid injury to personnel by dislodged needles. Considerable tissue damage and discomfort can be caused by irritating vehicles, drugs or solutions when injected into animals. The rabbit does not have a foot pad and injection into the bottom of the foot is not acceptable.