In these circumstances many neurologist recommend the use of immune- suppressant medications such as Cytoxan, Methotrexate and Imuran. Controlled clinical trials using these medications are difficult. A recent article from the Cleveland Clinic suggested a beneficial effect for Methotrexate. Multiple treatment protocols for the use of Cytoxan exist. High dose of Cytoxan has been administered initially with lower monthly maintenance dosages.
Maintenance therapy is necessary after the initial dose.
Other neurologists have used lower doses of Cytoxan on a monthly basis. Anecdotal reports suggest that Cytoxan has been beneficial in many patients, improving motor function and retarding disease progression. Answers have been provided by leading neurologists are intended for educational and informational use only. Comments are based on professional experience and do not represent therapeutic recommendation or prescription. Property of Multiple Sclerosis Only.