As with any new drug, there is possibility of rare hypersensitivity or idiosyncratic reactions that cannot usually be detected in initial premarketing trials. Recent report of Churg-Strauss vasculitis in patients receiving both steroids and zafirlukast. Zileuton tablets Indications Long-term control and prevention of symptoms in mild persistent asthma for patients 12 years of age. Mechanisms 5-lipoxygenase inhibitor. Elevation of liver enzymes has been reported.
Limited case reports of reversible hepatitis and hyperbilirubinemia.
Zileuton is microsomal CYP3A4 enzyme inhibitor that can inhibit the metabolism of terfenadine, warfarin, and theophylline. Doses of these drugs should be monitored accordingly. All rights reserved.