Kupffer cells are located in the space of Ito.
Liquid can leave the liver via the hepatic vein or via lymph ducts.
One major difference between capillaries and sinusoids is that sinusoids have gaps in their walls, allowing fluid to leak out freely. One treatment for endstage cirrhosis of the liver is to bore a hole through the liver, connecting incoming blood from the portal vein and hepatic artery with the outflowing blood of the hepatic vein. This mechanism would decrease portal hypertension. In cirrhosis of the liver , hyperinsulinemia occurs. If the varices rupture, the high blood pressure would cause severe, possibly fatal bleeding.