The long-term safety and role of the new TNF inhibitors remains to be established. Pantoprazole is briefly reviewed. Authors conclude that it appears to be as effective as other proton pump inhibitors, and is less expensive. The value of reporting therapeutic ineffectiveness as an adverse drug reaction Meyboom RHB et al. 99 Therapeutic ineffectiveness is a frequent drug-related problem that can occur in a variety of different situations and be caused by different mechanisms.
Examples are inappropriate use, interactions or metabolic abnormalities.
Observations in patients of unexpected ineffectiveness can provide important information with regard to such situations. A review of this subject. An extensive review of this subject. Because of the widespread use of HMG-CoA therapy, a clear picture of their relative tolerability has emerged. This review discusses their adverse, ocular, central nervous system, hepatic and muscular effects, drug interactions, the relationship between low cholesterol levels and mortality, and trial overview in primary and secondary prevention.