In the guinea pig, glutathione conjugates are readily hydrolyzed within the biliary tree to the cysteine- S conjugates which can then be reabsorbed from the bile back into the liver. Changes in the activity of hepatic GGT could therefore influence the retention and thus the toxicity of methyl mercury. Differential tissue expression and developmental patterns of the six GGT mRNAs indicate a complex regulation of this important enzyme. Thus, like phase I and phase II elimination reactions, phase III elimination has both detoxification and bioactivation roles, so that either inhibition or stimulation of this pathway can modulate toxicity. Vore M. Estrogen cholestasis.
Ethinylestradiol treatment induces multiple canalicular membrane transport alterations in rat liver.
Vore M. Prolactin regulates maternal bile secretory function postpartum. Glutathione conjugate mediated toxicities. Hinchman CA, Matsumoto J, Simmons TW, Ballatori N. Intrahepatic conversion of a glutathione conjugate to its mercapturic acid.