TS is pretty easy. With your sampler connected via SCSI, run TS and your SCSI bus will be scanned showing all devices. Choose the device you want to talk to. You can do a Get Catalog to list all of the samples in your device. TS handles all of the conversions, splitting stereo files, etc.
Loops come across perfectly.
Like we said, TS is designed to be fast and efficient. Add easy to that as well. Yes, TS supports the Mac Sound Manager. This means it works with Audiomedia, Korg 1212 and other new PCI cards coming into the market that support Apple's Sound Manager. TS does not use MIDI at all, except to talk to a Roland S760.