Associated complications occur rarely. Clinical manifestations may vary, depending on the strain of virus causing the infection. All enteroviral infections may cause fever. Most symptomatic patients report this complaint. The rash is not pruritic and does not cause skin desquamation.
Lesions characteristically appear as vesicles or ulcerations with an erythematous margin.
Often these lesions are the first physical finding. The lesions typically are less than 5 millimeters in diameter, and each patient can present with 2-12 lesions. Uninvolved portions of the pharynx usually appear normal. The most commonly affected structures are the anterior pillars of the fauces, posterior pharynx, soft palate, uvula, and tonsils. Erythema of the pharynx may range from mild to severe.