We study the physiological, biochemical, and molecular control mechanisms that mediate adrenal steroid hormone production in neonatal and adult animals. The neonate is an especially interesting model for study, since glucocorticoids are vital for normal fetal and neonatal development, and abnormal steroidogenesis during this time may have life-long consequences. The developmental signals that permit the onset of glucocorticoid production have been investigated for many years. Studies are underway to determine the regulatory controls that govern expression of this important protein.
Glucocorticoids are also potent catabolic hormones, and regulate both sugar and fat metabolism.
We recently discovered that fatty acids modulate adrenal steroid production, and we are currently investigating the mechanisms of those actions. In a related study, we are investigating the role of the so-called obesity hormone, leptin, in pregnancy and lactation in mammals. The dependence of leptin and hypothalamic neuropeptides on seasonal cues associated with hyperphagia, weight gain, and hibernation is also being investigated. The interactions between the brain, adipocytes, and adrenal glands are being studied at multiple levels of organization. Brake P, Arai, M, As-Sanie, S, Jefcoate, C, and Widmaier EP 1999.