Variable hepatic and renal. One of the things I like Lidocaine. It is a fast sodium channel blocking drug and when I say that I mean it binds and releases in a matter of 200 milliseconds. Because it doesn t have any potassium channel blocking effects, it tends to shorten action potential duration, not lengthen it. Cousins to lidocaine include Dilantin and mexiletine among our antiarrhythmic drugs.
Half life is short.
Remember it is predominantly Quinidine. Great drug, been around for over 400 years. The tale goes that there was a sea captain, the Disopyramide. I always remember when this drug first came out. It was the first of the wonder antiarrhythmic drugs.