Abstract from 1996 SRA Annual Meeting Abstract of Meeting Paper Society for Risk Analysis 1996 Annual Meeting Chromosome Studies of Pediatric Patients on Long-Term Nitrofurantoin or Furagin Therapy for Urinary Tract Infection. Earlier findings have indicated certain carcinogenic and genotoxic effects of nitrofurantoin.
Little information exists on genetic effects of furagin.
Their ages ranged from 0.3 to 13, with a mean of 6.2 years. The mean blood urea and creatinine levels of all patients were within normal range. However, significantly increased frequencies of SCEs were determined in patients on furagin therapy. No correlation was observed between the SCE rates and duration of therapy.