The cream is readily absorbed and leaves no trace after a few minutes. During absorption the cream bypasses the liver and goes to specific receptor sites where progesterone is needed. When the action is completed, residue is then excreted from the body. Absorption rate varies from person to person as does the relative need for progesterone. It matches exactly the chemical formulation of the body's own progesterone.
Manufacturers alter the chemical makeup of progesterone in order to create progestins.
Progestins in their altered molecular structure may cause many side effects, such as birth defects or abortion, fluid retention, epilepsy, migraine, asthma, cardiac or kidney dysfunction and depression. There are many factors that affect both of these conditions, one common factor being a higher level of circulation estrogen, indicating a hormonal imbalance. Progesterone is the precursor hormone and it helps to normalize all other endocrine and hormonal activity in the body. In this case, assisting to lower the level of estrogen in the body and thus, possibly helping to clear these conditions. Many medical authorities tell female patients who are post-menopausal that osteoporosis is inevitable.