Bone density was measured in the lumbar spine, femoral neck, and femoral trochanter. After two years of treatment there was a significant percentage increase in bone density in the etidronate treated group. No significant bone loss occurred in the hip in placebo treated patients. Cyclic etidronate is an effective treatment for postmenopausal women receiving corticosteroid treatment and is well tolerated. Nevertheless, the mechanisms leading to cardiac injury and irreversible cellular changes remain elusive.
Free radicals are the critical mediators of cellular damage during ischemia-reperfusion.
Intravenous cocaine administration also had negative effects on cardiac oxidative stress measures. In conclusion, the data indicate that cocaine administration compromised the heart's antioxidant defense system. 1151-1154 Nocturnal leg cramps is a common and troublesome problem in elderly individuals, and their cause is unknown. Treatment with quinine is a common practice, but the effectiveness of the drug is doubtful and adverse drug effects are common. Both the patients taking vitamin B capsules and those taking placebo received medications three times daily.