Other factors that influence choices about such therapy include the impact of the recurrences on the patient's well-being and quality of life, the need for prophylaxis for other fungal infections, cost, toxicities, drug interactions, and the potential to induce drug resistance among Candida and other fungi. Adults or adolescents who have a history of documented esophageal candidiasis, particularly multiple episodes, should be considered candidates for chronic suppressive therapy. However, the potential development of azole resistance should be taken into account when long-term azoles are considered. Special Considerations Children 5. Pregnant Women 7.
Experience is limited with the use of systemic antifungal drugs during human pregnancy.
These same potential risks of teratogenicity are presumed to apply to other systemically absorbed azole antifungals, such as ketoconazole.