Using physiological, biochemical, cellular and molecular biological approaches, we are examining the effects of dietary salt intake and genotype on the expression of autocoid receptor isoforms and their intracellular second messengers as an approach to understanding possible etiologies of salt-dependent hypertension. Microtubule disruption prevents an AVP-stimulated chloride secretion but not sodium reabsorption in A6 cells. Dopamine inhibits vasopressin-dependent cAMP production in the rat cortical collecting duct. Dopamine D4 receptor isoform mRNA and protein is expressed in the rat cortical collecting duct. Renal water and ion transport systems.
Dopamine inhibits vasopressin-dependent cAMP production in the rat cortical collecting duct.
The collecting duct, dopamine, and vasopressin-dependent hypertension. Interaction of modeling and experimental approaches in understanding renal salt and water balance.