This week's artwork was donated by Dathan, a pediatric cancer patient who received treatment at The Children's Hospital of Philadelphia . The myeloid and megakaryocytic series in the bone marrow appear normal, but megaloblastoid erythroid hyperplasia is present.
Dysplasia is usually minimal.
Macrocytic anemia with reticulocytopenia is present in the blood. Transformation to acute leukemia is rare, and median survival varies from 2 to 5 years in most series. There is significant evidence of disordered myelopoiesis and megakaryocytopoiesis in addition to abnormal erythropoiesis. Approximately one-third of patients present with this type. Auer rods may be seen.