We've all lost seasons we should have won simply because the fates were against us. Figure about a third of your success is due to luck. Injuries, player movement and managerial whim can wreak havoc with the most perfectly drafted team. The best we all can do is maximize the results we get out of the other two thirds. Well, you heard it from the best.
Luck plays a major factor.
In the Webmaster's league last year I had the second pick in draft auction. I took Maddux. Then I was going to wait until late in the draft for other pitching. If Maddux would have been injured, it would have been death for me. I banked on his stats carrying my pitching.