This general category of skin tumors is a general term for benign tumors of epidermal keratinocytes. The unifying characteristics include a benign behavior, epidermal acanthosis or hyperplasia, and lack of dysplasia. Epidermolytic acanthoma May be solitary or disseminated resembling a wart. Histology shows epidermolytic hyperkeratosis. Usually solitary resembling a wart on the head and neck of middle-aged to elderly patients.
Histology shows suprabasilar clefting, acantholysis, dyskeratosis, and keratinous plug.
Acantholytic acanthoma Solitary tumor on trunk of older patients. Multiple lesions may be seen in renal transplant patients. Histology shows hyperkeratosis, papillomatosis, acanthosis, and variable acantholysis. Dermatosis papulosa nigra May be a variant of seborrheic keratosis. Almost always found on head and neck area in black females.