Synchrotron data collection, data processing, anomalous diffraction, phasing methods, density modification methods, refinement. Emphasis is on applications and currently available methodology. Macromolecular Modelling and Structure Analysis. Introduction to graphical analysis, modelling and simulation of macromolecules. Course will alternate lectures and hands-on computer modelling sessions.
Enrollment is limited to twelve.
Structural Basis of Protein-Nucleic Acid Recognition. BMB 555 or equivalent. Transcription, replication, recombination, and repair of DNA are discussed with an emphasis on structural and mechanistic aspects of the systems. A survey of biological membranes and membrane-associated processes. The composition and physical properties of cell membranes will be considered, as will structural aspects of membrane proteins.