Magnesium concentration has an effect on serotonin receptors, . . . NMDA receptors, and a variety of other migraine-related receptors and neurotransmitters. . . . Infusion of magnesium results in rapid and sustained relief of . . . The study also found through two double-blind studies that oral magnesium supplementation may also reduce the frequency of migraine attacks. The report concluded, Because of an excellent safety profile and low cost, and despite the lack of definitive studies, we feel that . . .
Magnesium supplementation is used widely in Canada as a preventive regimen.
The study concluded, magnesium deficiency and abnormal presynaptic calcium channels may be responsible for neuronal hyperexcitability between attacks. Decreased serum and intracellular levels of magnesium have been reported in patients with migraine. It was also found that platelet levels of ionized magnesium were significantly lower in patients who suffer from migraine headaches. A study conducted at the University Department of Neurology in Liege, Belgium postulated the brains of migraineurs were characterized by reduced mitochondrial phosphorylation. Riboflavin could be used because of its potential to increase mitochondrial energy efficiency in the brain.