Iron is absorbed from the duodenum and upper jejunum by an active mechanism through the mucosal cells where it combines with the protein transferrin. Iron is stored in the body as hemosiderin or aggregated ferritin which is found in reticuloendothelial cells of the liver, spleen, and bone marrow. About two-thirds of total body iron is in the circulating RBCs in hemoglobin. Absorption is enhanced when stored iron is depleted or when erythropoesis occurs at an increased rate.
Food decreases iron absorption by up to two-thirds.
Least expensive, most effective iron salt for PO therapy. The exsiccated form is more stable in air. Dietary supplement for iron. Optimum therapeutic responses are usually noted within 2-4 weeks. Hemolytic anemia, pyridoxine-responsive anemia, and cirrhosis of the liver.