It tends to accumulate in the liver, kidney, spleen, lungs and testes. Bio-transformation occurs rapidly into an active metabolite with identical effects. The active metabolite is transformed into inactive metabolites. Most metabolization takes place in the liver, but some takes place in the lungs. Complete elimination may take up to a month.
Effects are clearly dose related.
The pharmacological effects of THC do not fit easily into categories established for other drugs. THC shares characteristics of stimulants, sedatives, analgesics and hallucinogens. At low doses it has sedative properties like alcohol and other sedative-hypnotics. THC is chemically similar to steroid hormones. Distinct receptor sites have been found in hippocampus, cerebellum, substantia nigra, mesolimbic DA pathways and the cortex.