Statistical Analysis 4. Results and Discussion 4.1. In VSM of Sprague Dawley, WKY and SHR Aortic Rings With Intact Endothelium 4.2. In the VSM of Aortic Rings Without Endothelium Among Sprague Dawley, SHR and WKY Rats 5. The SHR strain is the most widely used model for the study of genetic hypertension.
Hypertension adversely affects calcium homeostasis.
Experiments were performed on rings from thoracic aortas of three strains with endothelial lining intact or removed to discern the paracrine control of endothelium on contractility in response to calcium import. Implications of these variations are discussed in this report.