Red eyed Goldens and Red Eyed Whites are also commonly used in developing a solid Saffron line. If you are attempting to breed these striking guinea pigs in this way, patience is the key. It can take some time, but with time the desired results can be achieved through crossing F1, F2, and F3 progeny. Out-crossing is often not recommended because the red eye gene is recessive. Guinea Pigs will generally be ready for breeding by 12 weeks of age, though they reach sexual maturity before then.
Males tend to mature later, being sexually mature by eight to ten weeks.
Mature females will go into estrus approximately every two weeks. The average female guinea pig will undergo a gestation period of 63 days. The litter consists of two to four babies. Babies are weaned sometime between 21 and 28 days after birth. It is generally not recommended to continue breeding guinea pigs after they reach two years of age.