Prasad Tata Otsuka America Pharmaceutical, Inc. 2440 Research Blvd. The MSDS will contain a list of references regarding toxic effects of Tween 80. The exact cause of the toxic event may not be discussed. When the same is administered IV the animal will experience an anaphylactoid reaction due to severe mast cell degranulation and subsequent histamine release. Of course one needs to make sure that these drugs do not interfere with the disposition of your test compound.
Hemolysis is also a problem.
Clinical chemistry on these animals showed increased hepatic enzyme levels that reverted back to baseline within 5 days.