List 3 properties of Lec 1 cells and describe what relevance those properties had to the experimental design. The experiments depicted in Figure 5 examine the effects of ectopic expression of a mutant Fringe. Multiple models for how fringe regulates Notch signaling are presented. Using your own words, describe two of the models. Lee, et al.
Genetic ablation reveals that the roof plate is essential for dorsal interneuron specification.
In your own words, describe the genetic ablation technique used in this study. The authors conclude that the epidermal ectoderm and the roof plate possess non-redundant functions in the specification of dorsal neural cell types. I in the posterior transport of oskar mRNA and staufen protein. Science 289, 2120-2. Link for those that have access to Science Online.