HRT is commonly prescribed to alleviate menopausal symptoms such as hot flashes. It has also been shown to reduce the risk of osteoporotic fractures and may have some cardiovascular benefits. Unfortunately, evidence suggests that HRT may increase the risk of breast cancer in post-menopausal women. HRT contains estrogen, a hormone believed to play a role in breast cancer development. In particular, the body metabolizes estrogen to a variety of compounds, and how a woman metabolizes estrogen may affect her risk of breast cancer.
Estrogen metabolism is determined by individual biologic and genetic factors.
BMI may be one such factor. Western Pennsylvania's only National Cancer Institute-designated comprehensive cancer center, UPCI serves a population of more than 6 million people and is a leader in translational research, the conversion of laboratory findings into applications of potential clinical importance. Physicians at UPCI use a wide range of modern technologies and facilities to help each patient receive individualized, comprehensive care. Ongoing studies at the institute lay the foundation for future diagnostic methods and treatments that often become employed nationally and internationally.