MUSE is now available by prescription throughout the United States. MUSE, the first and only non-injectable delivery system for alprostadil, was recently cleared for marketing by the Food and Drug Administration. MUSE is indicated for the treatment of erectile dysfunction. MUSE is a non-injectable, transurethral drug delivery system consisting of a prefilled plastic applicator containing a urethral suppository of alprostadil. Transurethral drug delivery is based on the discovery that vascular communications exist between the corpus spongiosum and the corpora cavernosa.
Local absorption relaxes smooth muscle, resulting in rapid arterial inflow and penile rigidity.
MUSE was shown to begin the erectile process in 5 to 10 minutes after application. After urination, the small applicator tip is inserted just over one inch into the urethra. By gently pushing the button on top of the applicator, an effective dose of alprostadil, in the form of a urethral suppository, is delivered directly to the urethral mucosa. MUSE is now available by prescription throughout the United States. A dedicated information line has been set up for health care professionals.