Those who are heterozygous for C282Y or H63D may or may not load iron at all. Scientists are just beginning to learn about iron loading in young patients. There is an increased risk for heart problems for these patients whether they possess HFE gene mutations or not. Family history and symptoms are the best guide a parent has to monitor the possibility of iron loading in their child. Again, it should be emphasized that iron overload is uncommon in very young children.
Iron levels fluctuate dramatically in young children, especially newborns.
For this reason, children younger than three should not be subjected to trauma of blood draw to determine iron status or be genetically tested unless the attending pediatrician considers it necessary.