Method of action in rheumatoid arthritis is unknown. It clearly ameliorates symptoms of inflammation but there is no evidence that it induces remission of rheumatoid arthritis or decreases bone erosions. The rate of epithelial cell production is increased when compared to normal skin. The actual mechanism of action is unknown. Severe rheumatoid arthritis not responsive to other treatments after consultation with rheumatologist.
Further metabolism occurs at the intracellular level and in the liver.
Hypersensitivity, pregnancy, breast feeding, alcoholism, bone marrow depression, severe hepatic function impairment, immunodeficiency, severe renal function impairment, or pre-existing blood dyscrasias. Avoid conception while taking this drug and immediately after discontinuing it. Do not breast feed while taking this drug due to risks to the infant. Do not receive any immunizations while receiving Methotrexate or for 3 to 12 months after receiving after receiving Methotrexate. Alcohol and hepatotoxic medications may increase risk of hepatotoxicity.