Standing BP is lowered more than supine. Significant reflex tachycardia and bradycardia do not occur although AV conduction may be prolonged.
Food increases bioavailability of the drug.
Alone or in combination with other drugs for hypertension. Cardiogenic shock, cardiac failure, bronchial asthma, bradycardia, greater than first-degree heart block. Safety and efficacy in children have not been established. After PO Use. Diarrhea, cholestasis with or without jaundice.