All instructions on the label must be followed. Round up Ready Cotton is an excellent tool. It is not however, a silver bullet . Proper management is required to allow RR Cotton to reach it's potential. Also, Roundup, Touchdown and similar products work best when applied in a timely fashion.
Management is the key.
This increase may be associated with reduced tillage practices and an increase in the acreage of cotton planted on heavier textured soils. Control of these weed pests is not simple and involves combinations of fall and in-season applications of herbicides. Where Roundup Ready cotton is planted, the application of two properly timed overtop sprays, followed by a directed spray, will also help. However, this program will need to be followed with the post harvest treatment. Perennial vines can be a significant problem.