It inhibits incorporation of mycolic acid into the cell wall of these organisms. Polymyxins are restricted to topical use. Highly toxic to kidneys. It is a polypeptide. E. Inhibitors of Protein Synthesis 1.
Examples are streptomycin, neomycin, kanamycin, gentamicin, tobramycin.
Fairly toxic, especially to kidneys. Neomycin is used topically. Gentamycin is useful in some gram negative infections including those caused by Pseudomonas . Kidney damage and damage to the auditory nerve are undesirable side effects. Tetracyclines Fig 20.11 are drugs obtained from several species of Streptomyces .