The onset of clinical signs occurs at 3-4 months of age. This disease has been reported in the Great Dane, Irish Setter, Irish wolfhound, St. Bernard, Labrador retriever, basset hound, greyhound, German shepherd, German short-haired pointer, borzoi, boxer, Dalmatian, Weimaraner, Doberman pincher, and collie. Clinical signs range from mild pain to severe pain, fever, and loss of appetite with a very poor prognosis.
Lameness varies in severity.
The affected long- bone may be extremely swelled at the ends of the bones. Physical exam and history are use to make the diagnosis. Affected bones are warm and swollen on palpation. Fever of up to 106 degrees may be present. Loss of appetite, reluctance to move and weight loss may be noted.