PCO often is associated with obesity, amenorrhea or abnormal uterine bleeding. Malnutrition - Low body weight causes the body to stop producing estrogen and ovulation ceases. Women who suffer from anorexia or bulimia often experience estrogen shutdown and do not have periods. The hormone leptin signals the brain about the percentage of body fat and can affect menstrual function. An altered prolactin level can affect the hypothalamus and disrupt the menstrual cycle.
Excess prolactin can interfere with the regulation of menstruation.
This type of tumor is rare and often can be treated with medication. A woman who experiences any of these symptoms should see a doctor. Period changes can be early-warning signs of other health problems. Several tests can be done to determine the cause of amenorrhea. Blood testing can be done to detect thyroid or pituitary disorders.