The liver is the major organ of acetone metabolism, and excretion occurs mainly through the lungs and in the urine. No information is available on the subchronic or chronic oral toxicity to humans. In animal studies, subchronic oral exposures were associated with kidney damage and hematological changes. Information on the inhalation toxicity of acetone to humans is derived from occupational and laboratory studies. Central nervous system effects can range from subtle neurobehavioral changes to narcosis depending on the magnitude and length of exposure.
Little information is available on subchronic or chronic inhalation toxicity in animals.
In the latter study, the incidence of malformations was not increased by exposure to acetone. Negative results have been reported in occupational exposure studies and in rodent skin painting studies.