My wife changed from Prozac to Zoloft 50 mg in February. Since then she appears increasingly to take offense at everything I say to her. She is also under great stress, having just started a new business. Everything I have read about Zoloft indicates that this is not a major side effect, but I would appreciate confirmation of that fact, since a PDR does not seem to be available on line. It sounds as if your wife has become increasingly irritable.
Irritability is a very nonspecific symptom and has many causes.
If your wife's irritability continues to worsen, she should be evaluated by her psychiatrist. As Zoloft uncovers a manic state in some people, it may be playing some role in the etiology of irritability. For the past 8 days, I have not taken any at all. I was wondering two things. When one stops Zoloft too rapidly a withdrawal syndrome may develop.