Because of its odor and irritant effects, toluene is regarded as having good warning properties. The chronic effects of exposure to toluene are much less severe than those of benzene. No carcinogenic effects were reported in animal studies. Equivocal results were obtained in studies to determine developmental effects in animals. Toluene was not observed to be mutagenic in standard studies.
Hazardous gases produced in fire include carbon monoxide and carbon dioxide.
Carbon dioxide and dry chemical extinguishers should be used to fight toluene fires. Reactivity and Incompatibility Contact with strong oxidizers may cause fires and explosions. In particular, toluene should be used only in areas free of ignition sources, and quantities greater than 1 liter should be stored in tightly sealed metal containers in areas separate from oxidizers. In the event of skin contact, immediately wash with soap and water and remove contaminated clothing. If toluene is ingested, do not induce vomiting.