ACN is associated with obesity and is often a sign of diabetes. Age-dependent skin changes . Age-dependent skin changes may be influenced by androgen disorders. Aging of the skin is due to actinic damage, chronologic aging and hormonal influences. Obesity is often associated with androgenic disorders and the android pattern of fat distribution is especially significant.
Excess fat is found mainly on the upper body, rather than in the hips and buttocks.
This is often a sign of insulin-resistant diabetes and lipid disorders. Congenital Adrenal Hyperplasia . It is the most common cause of ambiguous external genitalia in infancy. A genetic defect, it is most common among Ashkenazi Jews, as well as Alaskan Eskimos, Hispanics, and those of northern European and Scandinavian descent. CAH is a collective term for a number of enzyme deficiencies in the synthesis of cortisol from cholesterol.