This medicine is occasionally associated with weight loss. I frequently use it in low doses in conjunction with other antidepressants to help with insomnia. This medication works well for chronic headaches and chronic pain syndromes. It is rarely used as a first line drug for depression because of sedation and other side effects. It is extremely useful for chronic headaches as a preventive medicine in very low doses so side effects are minimized.
Low doses are also effective for use as a muscle relaxant and for chronic pain syndromes.
It elevates norepinephrine and seratonin but by a different mechanism than other antidepressants. It is helpful for people that have weight loss because it stimulates the appetite in some patients. It can be quite sedating. It has minimal side effects but occasionally can cause sexual dysfunction. St. John's wort-Probably worth a try in mild depression.