Some reports have noted response to topical or injected corticosteroids. Patients with presumed lymphocytoma cutis in which the possibility of lymphoma cannot be excluded should likely be evaluated for the possibility of concurrent extracutaneous disease and careful follow-up evaluation for a possible emergence of lymphoma. Rare case reports have described evolution to lymphoma. It is possible that a significant percentage of these cases represented histologically subtle lymphoma from the outset. If the offending agent is removed, resolution will be achieved.
Idiopathic examples tend to be chronic and indolent.
Spontaneous regression may occur over the course of months or a few years. Local recurrence has been noted. Lymphocytoma cutis caused by an arthropod bite exhibits an erythematous scaling patch of the scalp with localized secondary alopecia. A mixed inflammatory infiltrate with germinal centers is indicative of lymphocytoma cutis. Well-developed lymphoid follicles in a background of mixed inflammatory cells with small lymphocytes is typical of lymphocytoma cutis.