Grief in its many forms sets in. When your world changes, a specialized form of doubt usually occurs. When something you were expecting from others or from the world is suddenly denied, you will tend to feel frustration and go through a period of grief. When your world shocks you into this profound doubt, you find yourself beginning to doubt most everything. You may begin to feel you cannot possibly find happiness or meaningful experience through your present relationships with others.
Life is no longer a party.
Nor does life seem to promise satisfaction anymore. No matter how good the world looks, it can leave you stranded or cause pain. Life has a vicious stinger. In this way your doubt grows into a gnawing, underlying anxiety that people and things cannot satisfy you in the long run. People may provide some satisfactions, but then again they may go away through inclination or burial.