Assessment of hepatic artery invasion by bile duct cancer using intraductal ultrasonography. Defining the criteria for local resection of ampullary neoplasms. A comparative study among clinicopathologic features, AgNORs, and DNA content analysis. Risk factors for gallbladder cancer. An international collaborative case-control study.
Gallbladder carcinoma is one of the most frequent neoplasms diagnosed in Chile.
Although the premalignant lesions have been extensively studied and are well characterized, there is only limited information about the genetic abnormalities that might be important in the pathogenesis of gallbladder carcinoma or that might have prognostic implications. The present study evaluates the immunohistochemical expression of p53 protein in premalignant lesions and invasive carcinoma of the gallbladder, and correlates the p53 expression with histological type, grade of differentiation, and level of invasion of the tumor. A semiquantitative scoring system was used to assess the p53 reactivity. There were no significant differenc- es in p53 expression in premalignant lesions associated with invasive carcinoma and those that were not. Normal and metaplastic epithelium did not overexpress p53 protein.