Utilizing MR and CT imaging the accuracy of the new system was evaluated with phantom studies and preliminary patient studies. The markers are clearly visible without artifacts on both imaging modalities. The clear delineation of the marker dots on the images enables an accurate automated marker detection. Using the marker system, image registration was found to yield an accuracy of up to 1 mm, depending on the imaging modality and the employed marker arrangement. The presented marker system shall improve patient comfort in comparison to conventional fixed stereotactic frames if repeated, highly accurate registrations are necessary over longer periods.
Experimental studies suggest a beneficial effect of hemodilution on acute ischemic stroke.
This was not proven by previous multicenter trials in the clinical setting. At least 600 patients per group would have been required for significant results, and therefore we decided to terminate the trial. Ninety-eight patients received HHD and 102 patients placebo. The baseline characteristics were comparable between both groups. HHD treatment was not associated with any specific adverse event.