The results can be printed out in a high quality format or exported to any spread-sheet editor. The prediction is based on the structural formulas of the compounds. We have compared predicted pKa values of about 400 drugs with measured values. Nowadays, the most widely used organic phase in logP determinations is octanol. This is because the absorption of a compound depends on its partition between the biological membrane and the aqueous phase.
LogP values are also important in separation technics and the prediction of the solubility of drugs.
There are many methods to measure logP, but in several cases, when only an approximate value is needed, a logP prediction can adequately substitute it. The PrologP 5.1 computer program predicts the logP values based on the structural formulas of the compounds. The program uses three different systems for the prediction. The concentration of the ionized forms in the organic phase is much less than that of the neutral form. PrologD 2.0 can predict the logD values of the compounds.