Washout period is 7 days.
Food decreases the time to reach peak plasma levels.
Metabolized to N-desmethylsertraline, which has minimal antidepressant activity. Plasma clearance may be lower in elderly clients. The possibility of a suicide attempt is possible in depression and may persist until significant remission occurs. Palpitations, hot flushes, edema, hypertension, hypotension, peripheral ischemia, postural hypotension or dizziness, syncope, tachycardia. Rash, acne, excessive sweating, alopecia, pruritus, cold and clammy skin, facial edema, erythematous rash, maculopapular rash, dry skin.