People with mono who are given ampicillin or amoxicillin may develop a significant rash which is very noticeable. This is a type II Downy cell. Mononucleosis is an infectious disease usually thought of as causing fatigue and swollen lymph nodes. However, mononucleosis has multiple other symptoms including various rashes. Interestingly, the antibiotic ampicillin significantly increases the rash.
Infectious mononucleosis causes a sore throat, enlarged lymph nodes, and fatigue.
Mononucleosis and sever streptococcal tonsillitis appear quite similar. Unless there are other findings to suggest mononucleosis, a throat culture and blood studies may be necessary to make an accurate diagnosis.