ECT successfully alleviated the symptoms and restored blood flow to the affected region. The researchers found that ketamine affected the metabolism in the frontomedial and anterior cingulate cortex. In some individuals the feeling may linger beyond the drug experience. It may be that the action of ketamine and the neurobiological changes due to schizophrenia and Cotard Syndrome are similar processes. The explanation that some individuals come up with, apparently, is the fixed, false belief that they have died.
Effects can range from rapture to paranoia to boredom.
The user feels its hallucinogenic effects and experiences impaired perception. There is depression of respiratory function but not of the central nervous system, and cardiovascular function is maintained. Ketamine may relieve tension and anxiety, is purported to be a sexual stimulant, and intensifies colors and sounds. Effects of chronic use of ketamine may take from several months to two years to wear off completely. Flashbacks may even occur one year after use.