This drug obeys the two compartment model. Upon oral administration, it is absorbed and goes through the liver before entering the blood circulation. It has a high first pass effect. I was not interested in this metabolism, but followed plasma levels of unchanged drug. What I need is, two compartment model drug with zero order release and first order absorption model equations for blood level.
Liver acts like the peripheral compartment into which absorption occurs.
But central compartment is the one sampled. Searching the literature did not yield the equations I needed. My Laplace transformation knowledge is not enough for this pupose, unfortunately. If you could be kind enough to derive these equations, I would be most grateful. Your effort would no doubt be cited in any paper I produce.