It was extensively utilized as a growth promoter for cattle and sheep and as a treatment for estrogen-deficiency disorders in veterinary medicine and, more recently, for postcoital contraception. Provide the cytologist with information regarding oral contraceptive pill and hormone use. If in doubt, perform a biopsy. Treat dysplasia as indicated.
Laser ablation is preferavle to cryotherapy on the cervix because of less potential stenosis.
Perform bimanual rectovaginal examination. Perform breast examination and mammographic follow-up as recommended for all patients of a similar age. Consider screening for autoimmune disorders. Problems in the examination of the DES-exposed female. In the mid-1950s DES began to be associated with a number of serious birth defects and other disorders of the reproductive tract in the daughters of women who had taken it during their pregnancies.