A necessary role for reduced intracellular potassium during the DNA degradation phase of apoptosis. Potassium is a critical regulator of apoptotic enzymes in vitro and in vivo. Non-Caspase proteases are required for chromatin degradation during apoptosis. Induction of apoptosis by the novel retiniod AHPN in human T cell lymphoma cells involves caspase-dependent and independent pathways. Thymosin fraction 5 inhibits the proliferation of the rat neuroendocrine MMQ pituitary adenoma and C6 glioma cell lines in vitro.
Intracellular potassium suppresses the activation of apoptosis in lymphocytes.
Potential roles of cyclophilins in apoptosis. Utilization of an in vitro apoptosis assay to evaluate chromatin degradation by candidate apoptotic nucleases. Candidate nucleases responsible for genomic degradation during apoptosis. The enzymology of apoptosis. The biochemistry and molecular biology of glucocorticoid-induced apoptosis in the immune system.