Every attempt has been made to insure the accuracy of this material, however, medical science is constantly changing. If the information on this page differs from what you have been told by a nurse, pharmacist or physician, consult the person who told you differently or the manufacturer. This in turn diminishes the response of the muscle to tetanic stimulation. Quinine decreases the response of muscle fibers to repetitive stimulation thereby decreasing cramping. Though the main indication is for malaria, the off-label usage that we are focusing on is the relief of leg cramps during hemodialysis as well as the relief of leg cramps at night.
Elimination is primarily renal.
Hemodialysis, peritoneal dialysis, and hemofiltration have little effect on plasma Quinine concentration. Clients with tinnitus, history of blackwater fever, thrombocyopenia associated with previous use of quinine, and pregnancy. Drug may cause congenital malformations. Separate administration by at least 2 hours. Monitor for toxicity.