The largest users of MIBK are companies that add it to protective surface coatings. Other companies add MIBK to adhesives, printing ink, and special lubricating oils. Companies also use MIBK to make pesticides and to separate and purify several other organic and inorganic chemicals. Drug companies use MIBK to extract and purify antibiotics and other drugs. Exposure to MIBK can occur in the workplace or in the environment following releases to air, water, land, or groundwater.
Exposure can also occur when people use certain paints, varnishes, or glues.
Methyl isobutyl ketone enters the body when breathed in with contaminated air or when consumed with contaminated food or water. It is also absorbed through skin contact. It is not likely to remain in the body due to its breakdown and removal in exhaled air and in urine. Methyl isobutyl ketone evaporates when exposed to air. It dissolves when mixed with water.