Acetaminophen is generally very well tolerated. This is important because too much acetaminophen can damage the liver. Also, combining acetaminophen and alcohol can result in quick and severe liver damage, so alcohol should be avoided while taking acetaminophen. This compound was introduced in 1974 and is often used where pain relief is needed without a large anti-inflammatory effect. It is inferior to aspirin in its anti-inflammatory effect and can cause gastrointestinal irritation.
Lower doses can control pain but higher doses are needed to treat inflammation.
Other side effects may include kidney toxicity, jaundice, nausea , dizziness, headache, or rash. Ibuprofen can cause stomach upset, diarrhea, dizziness, drowsiness, gas or heartburn, and headache. It can also potentially cause gastric ulcers. Smoking or drinking alcohol while taking ibuprofen can increase your likelihood of developing ulcers. It should not be taken with aspirin because the combination can cause further stomach upset and also cause blood clotting impairment.