The area encompasses 20 sq. Ekwok is in a climatic transition zone. The primary influence is maritime, although a continental climate also affects the weather. Precipitation averages 20 to 35 inches each year. Extremely strong winds are common during winter months.
Fog is prevalent during summer months.
During the 1800s, the settlement was used in the spring and summer as a fish camp, and in the fall as a base for berry-picking. By 1923, it was the largest settlement along the river. In 1930, a BIA school was constructed. Mail was delivered by dog sled from Dillingham until a post office opened in 1941. Many of the earliest homes in Ekwok were located in a low, flat area near the riverbank.