The advanced nephrosclerosis results in urinary dialysis. Most prominent pathological feature is glomerulosclerosis. We focus on the process of glomerular injury. This project may contribute to the elucidation of the age-associated nephrosclerosis. Liver and kidney express SMP30 with high amount.
Figure shows the expression of renal tubular epithelial cells.
This molecule plays the enhancement of plasma membrane calcium pump. Moreover, the decrease of SMP30 may introduce the dysregulation of intracellular calcium level. This dysregulation may result in the organ failure of elderly people. Pathophysiological functions of vasoregulatory substance, adrenomedulin. Adrenomedulin is vasoregulatory substance.