Special attention is given to ovarian sex streoid modulation of analgesic mechanisms and differences thereof between males and females. We are defining the role of eIFs in each of these stages in the initiation process. Ellen Hsu , We study the molecular mechanisms involved in the generation of antibody diversity and the evolution and role of DNA rearrangement and somatic hypermutation in vertebrates. Ira Kass, We examine the mechanisms of anoxic brain damage using the in vitro rat hippocampus. Measure electrophysiological parameters and ATP, Ca, Na and K levels.
Emphasis is on how anesthetics effect anoxic brain damage.
Cellular radiation lethality in terms of DNA DSB repair kinetics. Chromosome structure-DNA organization. John Lewis , We study mechanisms by which interferons regulate expression of genes and their effects on sensitivity to virus infection and mitochondrial function. Interference with interferon signaling mechanisms by viruses. Mary Makowske , Protein kinase C is a family of homologous isoenzymes involved in many signal transduction pathways.