These treatments are not always effective. Recently, HPV infection has been clearly shown to be associated with the development of cervical carcinoma in women. Direct roles for the HPV proteins E6 and E7 in the oncogenic process have been described. E7, on the other hand, binds a cellular protein called pRB, the retinoblastoma protein. This latter process is depicted in the diagram on the above.
Early diagnosis is the key to effective treatment.
Since HPV is a sexually transmitted disease , the threat to public and individual health is very real. There is currently no effective chemotherapy or prophylaxis for HPV infection.