Larger, more eosinophilic Oxyphilic cells derive from chief cells. Levels of PTH are regulated by a classic feedback loop. Primary-intrinsic to parathyroid gland. Hypersecretion of PTH with resulting hypercalcemia and hypophosphatemia. The result is hypocalcemia and hypophosphatemia.
MEN can present with hyperplasia or adenomas of parathyroid glands.
Neuromuscular weakness, anxiety, psychosis, coma. Metastatic calcification of soft tissues is also observed. Many are monoclonal and therefore represent true neoplasms. They may be pure or mixed cell in type, mostly of chief cells. A thin rim of normal tissue helps differentiate this lesion from hyperplasia.