Isaac is not killed, but the symbolism of his being offered as a sacrifice is carried out in Genesis 22. That the image of Abraham's only seed is a sacrificial image should make us note the parallel to Yeshua, who is also a child of miraculous birth, the only son of His Father, who is offered as a sacrifice. The seed-promise is next passed on to Isaac's son, Jacob, and then to the twelve children of Israel. However, there is a promise to Judah which indicates that the messianic ruler will stem from Judah. All of the Targums identify this promise with the Messiah.
Many centuries pass before the seed-promise becomes more explicit.
The figure of Moses, a prophet, priest and ruler of his people was considered to pre-figure the Messiah by many Jewish people before Yeshua came. It relates to the future ruler and representative of Israel. David is promised in this passage an everlasting throne through his descendants. Isaiah makes it clear that this will be fulfilled by one child. The contrast is drawn between this child and the wicked King Ahaz, who would not ask for a sign to prove God's will as requested by the prophet Isaiah.