In some years 40 percent of the all beaver trapped in Alaska originate on the refuge. The annual beaver harvest is about 20,000 pelts. Other furbearers include muskrat, weasel, wolverine, lynx, marten, and red fox. The abundant moose on Innoko have meant a food supply for early residents, explorers, trappers, gold-seekers, and river boat crews as well as today's residents. A float trip on the Innoko River provides an excellent opportunity to view wildlife.
Fishing is excellent for northern pike.
Sport hunting for moose and black bear is popular.