3-5 Myocardial Scar Note the extensive irregular dense white tissue replacing the myocardium. Old Myocardial Infarction Fibrous scarring often affects the endocardium overlying an area of healed infarction. Since myocardial cells cannot regenerate, necrotic myocardium is replaced by fibrous tissue.
Fibrosis is, therefore, non-specific .
Note the fibrosis and the hypertrophic features of the residual surviving myocytes.