There may be pre and postnatal onset growth retardation. There is an average IQ of approximately 63 and fine motor dysfunction manifested by weak grasp, poor eye- hand coordination, and tremulousness. There may be irritability in infancy progressing to hyperactivity in childhood. There is mild to moderate microcephaly, short palpebral fissures, and maxillary hypoplasia. Other findings include a short upturned nose, a smooth, wide philtrum, and thin, smooth upper lips.
Heart murmurs are common and most frequently associated with ventricular septal defects.
Other occasionally associated anomalies include ptosis of the eyelid, cleft lip and cleft palate, micrognathia, protruding ears, mildly webbed short neck, cervical vertebral malformations, rib anomalies, strawberry hemangiomata, hypoplastic labia majora, hydrocephalus, and short fourth and fifth metacarpal bones. There is continued postnatal growth retardation, with patients frequently presenting with failure to thrive. In the absence of serious central nervous system abnormalities, the overall prognosis is rather good. There is typically mild mental retardation and moderate growth failure. Jones, K. Patterns of malformation in offspring of chronic alcoholic mothers.