These ulcers are mildly to moderately painful. Small white blisters or red spots on the hands and feet, usually on the palms and soles, and in between the fingers. These are often tender. They do not itch as in chickenpox.
Hands are more often involved than feet.
Occasionally, blisters or red spots can also occur on the buttocks, genitalia and extremities. The most common group of viruses that cause Hand, Foot and Mouth Disease are Coxsackie A viruses, especially A16, but there are other viruses called enteroviruses which can cause this. There are many strains, so a child can have this disease more than once. It has no relation to a disease of cattle called Hoof and Mouth disease. The fever usually lasts up to 4 days.