Panel D shows a LB cut in the sagittal plane in a nigral neuron. Note how it extends into the proximal axon. In addition to LBs, these disorders share other pathology. In addition, there is extensive synaptic pathology seen in the perforant pathway in LB disorders. Panel F demonstrates degenerate mossy fiber terminal surrounding hilar neuron in DLB by light microscopy.
Insets show higher power magnification of GCIs.
In Press 2000. Clinical and Pathologic Implications. Alpha-synuclein Cortical Lewy Bodies are Markers for Dementia.