To determine whether this is the case, we are determining the three-dimensional structure of the complex of the NS1A protein with its specific RNA targets. Another function of the NS1A protein is the inhibition of the splicing of pre-mRNAs in the nucleus. However, other experiments suggest that there is at least one other mechanism of splicing inhibition and that this mechanism is mediated by the effector domain of the NS1A protein. We anticipate that our investigations into the mechanisms by which the NS1A protein regulates cellular functions will continue to provide novel information about the regulation of both cellular and influenza viral mRNA processing. In addition, the research projects in this laboratory are expected to provide new approaches for the development of influenza virus antivirals.
Influenza virus causes widespread human disease.
During pandemics, a much greater loss of life occurs. The 1918 pandemic was the worst. At least 20 million people died worldwide, many of whom were young adults in the prime of life. The reason for the high pathogenicity of this particular virus strain has not yet been ascertained . The potential for the re-emergence of a highly pathogenic influenza virus strain is exemplified by the sudden appearance of a lethal virus in Hong Kong in 1957, which killed six out of the eighteen infected individuals.