An introduction to the use of computers in analysis of gene sequences and molecular modeling. Students will learn to use a variety of computer software important to research in molecular biology, with emphasis on use of the Wisconsin Sequence Analysis Package. A lecture course that surveys the fundamentals of molecular biology. Topics include nucleic acid structure, DNA replication and repair, transcription and translational control, microbial and human genetics. These topics are discussed with emphasis on the use of molecular approaches to research in these areas.
Emphasis is on eukaryotic systems and review of pertinent research literature.
Human Molecular Genetics. Emphasis will be placed on the search for genes which contribute to simple single-gene disorders and common complex diseases. Topics include genetic mapping in humans, construction of physical maps of chromosomes, identification of coding sequences and disease susceptibility genes, and functional analysis of gene products. Bowden 741, 742. Tutorials in Molecular Biology.