Hepatic enzymes should be obtained initially, and repeated at 24-hour intervals. The prescriber must determine the number of tablets per dose, and the maximum number of tablets per 24 hours based upon the above dosage guidance. This information should be conveyed in the prescription. It should be kept in mind, however, that tolerance to codeine can develop with continued use and that the incidence of untoward effects is dose related. Equivalently high doses in children would have similar effects.
Federal law prohibits dispensing without prescription.