Extremely high titers are associated with the presence of rheumatoid nodules. Synovial fluid white blood cell count. Characteristic changes in RA include periarticular osteoporosis, symmetric narrowing of the joint space, and marginal bone erosions. Provide symptomatic relief but do nothing to suppress the rate of cartilage erosion or to alter the course of the disease. Zero-order release aspirin products such as ZORpin and Easprin may make aspirin products easier to take.
Glucocorticoids have anti-inflammatory and immunosuppressive effects and reduce joint erosion.
They are used especially for life-threatening manifestations such as vasculitis. Intra-articular steroids may be helpful. Combinations of steroids with other slow-acting antirheumatic drugs may be beneficial. Believed to modify the fundamental pathologic process. Oral gold sodium thiosulfate tends to be less toxic than other medications but is less effective.