Extra rest is needed for fatigue. Antibiotics are not effective in treating mono. The illness is caused by a virus and antibiotics are effective only against bacteria. Antibiotics could be used to treat a co-existing disease such as strep throat. If you have been diagnosed as having mono, it is not necessary to isolate yourself from other people.
Good hygiene is all that is required.
Eat a normal well-balanced diet. Avoid drinking alcohol because there are usually minor changes in your liver during the acute stages of mono. You may be as active as your strength permits. You may need to set priorities because your energy level may be less than normal. See your practitioner periodically to make sure that you are recovering from the infection and that no serious complications develop.