Knowledge of acceptable bioavailability and corticosteroid utility in many indications for these agents has encouraged their use in the oral form. In the absence of comparison studies, most panelists recommended dexamethasone or methylprednisolone because of the published experience with these agents. Single doses of corticosteroids are recommended. B. Some comparison trials have explored these issues. Until recently, these trials have typically been consecutive dose-level investigations rather than randomized studies.
Findings suggest that single doses are as effective as multiple-dose schedules.
Although few studies have addressed this issue, there is no benefit to starting the corticosteroid the day before chemotherapy. 121 Side effects of single corticosteroid doses are rare, although elevations of serum glucose levels and sleep disturbances occur. The Panel achieved consensus that single-dose regimens are most appropriate.