Highly malignant neoplasms with rapid turnover as in Burkitt's lymphoma. Tumor lysis syndrome due to chemotherapy. Breakdown of extramedullary hematopoietic cells in the first few days of an infant's life. On section, the renal papillae show yellow radiating striations reflecting the anatomic arrangement of the collecting ducts in the medullary pyramid.
Histology shows luminal obstruction of the distal tubules and collecting ducts by urate crystals.
Acute uric acid nephropathy occurs when there is a sudden massive breakdown of nucleated cells, as in tumor lysis syndrome when chemotherapy is instituted. This condition can also occur in infants during the first few days of life when extramedullary hematopoietic cells breakdown. Clinically, renal manifestation can be that of acute renal failure. Robbins Pathologic Basis of Disease. Medline will open in a new window.