Toxin is a protein of two subunits. Erythrogenic toxins of Scarlet fever produced by lysogenic strains of Strep. These toxins damage capillaries, resulting in the release of red blood cells into the skin and a resultatn rashl. A is active, B is binding. A induces cAMP in these cells.
Epithelial cells discharge large amounts of fluids and electrolytes.
Exert effect when cells die and lyse - this can happen after antibiotic treatment. Fig 15.5 Pyrogenic response. Symptoms are more general - fever, shock, malaise. TNF damages blood vessels and permits escape of fluid. This lowers blood pressure and results in shock.