This model is not unique. The kindling model, as it applies to seizures, suggests that each seizure occurrence increases the chance for another seizure. Eventually, Dr. Post said, a trigger stressor is no longer needed, and the system goes on automatic. At this point, neuronal pathways are sufficiently sensitized that depression can occur spontaneously. According to the sensitization model, each depressive episode can increase the chance of a future episode.
Family members can be instrumental in helping the patient get proper treatment.
Depression is a serious illness and should be treated as one. 2Chief, Biological Psychiatry Branch, National Institute of Mental Health.