A synthetic analog of arginine vasopressin which possesses antidiuretic activity but is devoid of vasopressor and oxytocic effects. Acts to increase absorption of water in the kidney by increasing permeability of cells in the collecting ducts.
Effect ceases abruptly.
Hypersensitivity to drug. Use for type IIB von Willebrand's disease. Parenteral administration for DI in infants under 3 months and intranasal administration in infants less than 11 months. Nephrogenic DI, polyuria due to psychogenic DI, renal disease, hypercalcemia, hyperkalemia, or administration of demeclocycline or lithium. Use with caution and with restricted fluid intake in infants due to an increased risk of hyponatremia and water intoxication.