For definition of Groups, see Preamble Evaluation. It is used as a reactive monomer in the production of polymers and coatings.
Few data are available on levels of occupational or environmental exposures to vinyl toluene.
No data were available to the Working Group. The mixed isomers were tested in one experiment in mice and one experiment in rats exposed by inhalation. No increase in the incidence of tumours was observed in any of the experiments. The vinyl moiety is first metabolized to form an epoxide, which is either conjugated with glutathione or further oxidized to a number of products, including carboxylic acids, which are conjugated with glycine. The methyl group can also be oxidized to a carboxylic acid and subsequently conjugated with glycine.