Geriatric clients may be more sensitive to the effects of hydroxyurea necessitating a lower dose. Dosage has not been established in children. Erythrocyte abnormalities including megaloblastic erythropoiesis. Constipation, redness of the face, maculopapular rash. Serum uric acid, BUN, and creatinine.
Intermittent dosage offers advantage of reduced toxicity.
If effective, maintain client on drug indefinitely unless toxic effects preclude such a regimen. Solid tumors, continuous therapy. Resistant chronic myelocytic leukemia. Concomitant therapy with irradiation for carinoma of the head and neck. Sickle cell anemia.