Scorpions cause significant threats to the public health in most of Latin America. Medical reports as early as 1938 associated scorpion stings in humans with immediate onset of acute pancreatitis. Our initial toxin isolations and characterizations were published with effects on pancreatic secretion.
Information derived from our studies utilizes the interaction of laboratories in Mexico and Brazil.
Joint research is facilitating molecular taxonomy, characterization of the venom protein structure and function, and potential production of improved clinical antisera. Our research in pancreatic acinar cell function and the effects of scorpion toxins has provided the basis for an approach to understanding pancreatitis and pancreatic cancer. Not only is secretory vesicle discharge directly affected, but also vesicular transport that is initiated at the endoplasmic reticulum. There is mounting evidence of effects that target additional cellular compartments including the nucleus and mitochondria. This research is revealing previously unknown interactions and examines important connections between cellular and subcellular functions of the exocrine pancreas.