Prevention of osteoporosis. Known or suspected cancer of the breast or estrogen-dependent neoplasia. Undiagnosed abnormal genital bleeding. Active or past history of thrombophlebitis, thromboembolic disease, or stroke. Liver dysfunction or disease.
Estrogens reportedly increase the risk of endometrial carcinoma in postmenopausal women.
Use with caution in conditions aggravated by fluid retention, including asthma, epilepsy, migraine, and cardiac or renal dysfunction. Estrogens may cause significant increases in plasma triglycerides that may cause pancreatitis and other complications in clients with familial defects of lipoprotein metabolism. See individual drug entries.