P. culpaeus seems to be more carnivorous than other species and reportedly sometimes preys heavily on introduced sheep and European hares. In western Argentina, during the spring part of the population of P. culpaeus shifts 15-20 km into the higher mountains, in response to the seasonal movements of the sheep and hares. P. griseus has been found to occur at an average density of 1 individual per 43 ha. The voice of Pseudalopex has been described as a howl or a series of barks and yaps. It is heard mainly at night, especially during the breeding season.
Females are monestrous.
The gestation period is 55-60 days. Embryo counts range from one to eight, with averages of about four in P. gymnocercus and five in P. culpaeus. The male helps to provide food to the family. At 2-3 months, the young begin to hunt with the parents. These canids are killed by people because they are alleged to prey on domestic fowl and sheep and because their fur is desirable.