In chronic erythroderma, serial biopsies may eventually reveal cutaneous T-cell lymphoma. Laboratory studies can reveal low albumin, elevated gamma globulin and an electrolyte imbalance. When clinically indicated, bacterial cultures of the skin and blood should be taken. If the erythroderma temporarily clears patch tests could be useful. A bone marrow examination should be done if leukemia is suspected.
Initial management requires hospitalization to monitor the patient closely.
There is significant heat loss because of capillary dilatation in the skin. Edema of the lower extremities is common due to low serum albumin from protein loss, secondary to severe exfoliation. High output cardiac failure and sepsis may occur. Generally, the patient needs to be kept warm and should be given warm water baths. Emollients and topical corticosteroids are applied to the affected areas.