Tributaries to the Green include the New Fork, Big Sandy and Blacks Fork. On the Green River, Fontenelle and Flaming Gorge Reservoirs have a capacity of over 4 million acre-ft and regulate flows on this major tributary of the Colorado River System. The Great Divide portion of this hydrologic unit is a closed basin of 3,959 square miles to the east. The coal and trona minerals industries as well as gas and oil development are prevalent in the basin. Concerns over groundwater contamination from industrial uses and natural fluoride deposits exist.
Industry is a principal user of the structural aquifers underlying the basin.
Salt and sediment loading of surface flows due to agricultural water use in the basin are a water quality concern. Colorado River Cutthroat Trout species are found in the Green River. The 1922 Colorado River Compact established the upper and lower Colorado River sub-basins, of which Wyoming is part of the upper basin. Actual water flows have been revised since 1922. Currently Wyoming's annual allotment is 833,000 acre-ft, for use in the Little Snake and Green River basins.