His boss named the disease after him.
Inheritance is auotsomal dominant, but can also be spontaneous.
Plaque foramtion seems to be an early and inevitible part of the disease. APP has 19 exons, and seeral different alternative splicing patterns are seen. All are multi-domain proteins with a single transmembrane region. There is similarity to the prion protein. APP gene maps to 21q21, a region where Alzheimer's disease was also mapped.