Platelet transfusions are not helpful, and infused platelets will be destroyed along with the patient's platelets. May want to use to try to stop acute bleeding, though. May take 2 to 3 weeks to see response. See package information for details. Splenectomy for patients who are bleeding and are not responding to other measures and bleeding.
Infection especially gram negative with endotoxin release.
Malignancy especially adenocarcinoma of pancreas and prostate, acute leukemia. Rarely head trauma, prostatic surgery, venomous snake bites, etc. Thromboembolic events including DVT, heart valve thrombosis, stroke, extremity infarction, etc. Serious bleeding complications with depletion of clotting factors. Will also have evidence of microangiopathic hemolysis including schistocytes, helmet cells, etc.