They may try to flee your hand and look to nearby objects for help. If you keep a snake in the middle of a room it will grow more used to you and relax a bit. Know when the snake has had enough handling, as it can be exhausting for them. If a snake appears to constantly be on a mission to leave your hand or arm, you can let it jump from one hand to the other. Snakes wear out quickly, and this kind of behavior may be a sign that they're tired, so leave it alone for a while in its cage.
Every snake is different.
Figure out the temperament of each one. Don't force your relationship with a snake. Do not handle venomous snakes. Unless you are well versed in large snake behavior, leave these animals alone as they can be deadly to a novice. Most snake handlers have been bitten.