Biotransformed in the liver to a sulfide, the active metabolite. Excreted in both urine and feces.
Juvenile rheumatoid arthritis, sunburn.
Use with active GI lesions or a history of recurrent GI lesions. Safe use during pregnancy has not been established. Use with caution during lactation. Stupor, coma hypotension, and diminished urine output. Additional Drug Interactions Sulindac effect of warfarin due to plasma protein binding.