Life on earth could not exist without its unique physical, chemical and electrical qualities. Perhaps it is due to its abundance that we take it so much for granted. The most elaborate dietary regimes and costly nutritional supplementation can only work if a person is well hydrated. When you become dehydrated a cascade of chemical events take place. Your body naturally begins to increase production of histamine.
Histamine is present in all body tissues and produced by the mast cells found in connective tissue.
Not only is histamine a mediator in inflammation, but it acts as a neurotransmitter, directing and operating the subordinate systems that promote water distribution to various tissues and organs. These subordinate systems involve the action of the hormones vasopressin and renin-angiotensin, as well as prostaglandins and kinins. When levels become excessively active the mucus membranes of the lungs, for example, can become irritated and in time the muscles and tissues that make up the breathing mechanism can go into spasm, resulting in severe breathing problems and at worse asthma . This in addition to long term damage to the immune system is bad news indeed for the athlete. When the core temperature rises while training the blood that would otherwise be available for the muscles is used for cooling via respiration and perspiration.