Abscesses often require surgical drainage. The granulomas ultimately resolve with long-term antibiotic therapy. Steroids reduce the gastrointestinal and genitourinary tract obstructions. Patients with anemia may require whole blood transfusions. Patients have been treated successfully with bone marrow transplantation, and this may be an option if a suitable donor can be found.
Gene therapy is under investigation.
They also developed the approved CGD treatment that uses gamma interferon. This treatment reduces the number of serious infections by up to 72 percent. The treatment can be given at home by subcutaneous injections three times a week. Syndrome Hyper-IgM is a rare immunodeficiency disease in which the immune system fails to produce IgA and IgG antibodies. Infants usually develop recurring upper and lower respiratory infections within the first year of life.