This pigment which is called cryptochrome is located in the front part of the retina in contrast to the visual pigment rhodopsin which is located in the posterior of the retina. Currently, we are investigating signal transduction from the circadian photopigment to the master circadian regulator called the suprachiasmatic nucleus in the midbrain. In addition, we are exploring ways to use cryptochromes as targets for drug or phototherapy of certain sleep disorders and psychiatric syndromes. Expression of cryptochrome 1 blue-light photoreceptor in the master circadian clock in the suprachiasmatic nucleus of the mouse. . Role of mouse cryptochrome blue-light photoreceptor in circadian photoresponses.
Excision repair invades the territory of mismatch repair.
Order of assembly of human DNA repair excision nuclease. Efficient nucleotide excision repair of cisplatin, oxaliplatin and JM216 platinum intrastrand DNA adducts.