Phenothiazines , which are antipsychotic drugs, have potent alpha blocking actions. J. Therapeutic Uses of Alpha Adrenergic Receptor Blockers 1. Sometimes used in treatment of peripheral vasospastic disease ie Raynauds disease to improve perfusion 4. In some patients, prostatic enlargement can cause urinary retention. Alpha blockers relax the sphincter muscle.
Major therapy is surgery.
Treatment of local excess concentration of a vasoconstrictor in order to prevent necrosis. K. Toxicity of Alpha Blockers 1. Reflex tachycardia, especially with agents that also block alpha 2 receptors. Other arrhythmias 4. Parasympathomimetic effects of phentolamine and tolazoline.