Hydrochlorothiazide is slightly soluble in water.
It is soluble in dilute ammonia, dilute aqueous sodium hydroxide and dimethylformamide. It is sparingly soluble in methanol. It is soluble in formic acid, sparingly soluble in methoxyethanol and very slightly soluble in alcohol. Dyazide capsules meet Drug Release Test 3 as published in the USP 23 monograph for triamterene and hydrochlorothiazide capsules.