After the bite of an infected sandfly, the incubation period ranges from weeks to months. Systemic symptoms generally are absent. Skin trauma can result in activation of cutaneous infection long after the initial bite. The lesion usually evolves over time. Healed lesions leave an atrophic scar.
Lesions can be pruritic or painful.
Lesions caused by some species can heal without pharmacotherapy, but healing can take months. Mucocutaneous leishmaniasis Incubation period is from 1-3 months. Mucosal lesions become gradually painful. Initial symptoms include nasal obstruction and bleeding. Many subclinical cases occur for each clinically recognized case.