No Change Drug Max. Doses recommended for systemic infections commonly treated with this agent.
Limited data are available for drug use in liver disease.
Recommendations should be considered generalized guidelines and patient specific regiments should be developed and therapy monitored carefully. Give dose after hemodialysis. Dosage reduction in renal disease is not necessary. However, due to the nephrotoxic potential of the drug, dosage reduction or holding the drug in the setting of a rising serum creatinine may be warranted. Aztreonam in ESRD should be given at 24h intervals only when treating highly susceptible organisms.