This translation by the NDI Foundation is to assist the lay reader. To provide a clear, accessible interpretation of the original article, we eliminated or simplified some technical detail and complicated scientific language. The NDI Foundation thanks the researchers for their work toward understanding and more effectively treating this disorder. There are about one million nephrons in each kidney. They consist of a filtering unit called a glomerulus , which is connected to a small tube called a tubule .
Fanconi syndrome is a complex of multiple dysfunctions of the kidney's tubules.
Its symptoms include excessive urinary excretion of phosphorus , calcium , uric acid , bicarbonate , potassium , sodium , magnesium , LMW proteins , glucose and amino acids . The drug ifosfamide is used in the treatment of various tumors in adults and children. However, it can have significant side-effects such as bleeding and inflammation of the urinary bladder and kidney poisoning that may include tubular and glomeruli impairment . Negro, et al. The authors counsel that patients receiving ifosfamide be monitored at regular intervals for any sign of kidney tubular dysfunction.