Female aged 11 years with severe mental deficiency, a small head and increased tone. Note the reduction in the number of gyri, and the increased thickness of the grey matter. Macroscopic features include cortical atrophy, subcortical zone of gliosis, poor definition of basal ganglia, and increased brain size. The pathology of the major conditions in this category will be discussed in the relevant lecture. Death due to bronchopneumonia.
Histology shows extensive neuronal loss and gliosis.
The leptomeninges have been removed to display the cerebral atrophy. Woman aged 54 with a four year history of progressive dementia. Died of bronchopneumonia. Histological examination shows argyrophilic plaques to be numerous. Decreased intensity of pigmentation of substantia nigra in a man aged 69 with idiopathic Parkinson's disease.