Lymphocytes travel locally in a lamina propria of a mucosa.
Wherever nodules may be found, close by are lymphoid cells dispersed more diffusely . 4 Most nodules have paler central regions - germinal centres , but these are not essential for cell proliferation. Germinal centres recruit virgin B cells, and follicular dendritic cells then present them with antigen. The B cells progressively refine their response to the antigen, in terms of Ig class, affinity, cell numbers, and whether to be plasma cells or memory cells. Primary-secondary Powerpoint .