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Kaletra is actually a combination of lopinavir and ritonavir in the same capsule. The addition of the drug ritonavir helps maintain higher blood levels of the protease inhibitor, Kaletra. The most important benefits of Kaletra are its effectiveness against resistant virus as well a slower progression of the virus to become resistant to other protease inhibitors . In addition, Kaletra is very well tolerate by patients when compared to other protease inhibitors. The typical dosage will be 3 capsules taken with food twice a day.