Mammalian cells require positive signals from growth factors for cell division.
Explain the dependence on serum or growth factors for mammalian cells in culture. Explain the mechanism by which tyrosine kinase growth factor receptors transmit the growth factor signal. Explain the functions of SH2 domains and SH3 domains. Describe the points of cross-talk between the Ras pathway and the PKC and PKA signal transduction pathways. Define the terms protooncogene, oncogene and tumor and suppressor gene.