Failure in one area can be ameliorated by success in another. In a sense, the modern corporation acts like a huge mutual fund of risk takers. So yes, I suppose pioneers do get arrows. However it makes no functional difference to the process of colonization. There will always be new pioneers to take their place.
Entrepreneurs tend to be very individualistic, free-thinking, creative people.
By their very nature, they are anti-corporate. It is enormously hard to gather them all in one place, under one roof, speaking the same language, wearing similar clothing, sporting corporate security badges, grumbling about lousy coffee and slow elevators. It can be done, but only for a very short period of time. Eventually they begin to disassociate. The entrepreneurial corporation either explodes or implodes.