We welcome these seven outstanding researchers to the ABTA family. Nicholas K. Foreman, MD Abrogation of Immunosuppressive Gangliosides in Glioblastoma Glioblastoma is a common and highly malignant brain tumor that occurs in all ages. Novel approaches are needed to significantly improve outcome for this group of people.
Gene therapy is an area of intense research.
This therapy is often aimed at stimulating an immune response to the tumor. While such therapy has shown promising results for certain cancers, glioblastomas appear to evade or block their host immune responses. This ability to block host immune responses must be overcome if gene therapy is to be successful. Gangliosides are complex molecules expressed on the cell surface of all human cells. These molecules are ubiqitous in the body but present in high concentrations in the brain.