T-lymphocyte formation leading to immunosuppression. Absorption from the GI tract is variable. 11.7 hr in liver transplant clients and 21.2 hr in healthy volunteers.
Food decreases both the absorption and bioavailability of tacrolimus.
Treatment of autoimmune disease and severe recalcitrant psoriasis. Concomitant use with cyclosporine. Headache, tremor, insomnia, paresthesia, seizures, coma delirium, abnormal dreams, anxiety, agitation, confusion, depression, dizziness, emotional lability, hallucinations, hypertonia, incoordination, myoclonus nervousness, psychosis, somnolence, abnormal thinking. Hepatitis, cholangitis, cholestatic jaundice, jaundice, liver damage. Hypertension, chest pain, abnormal ECG, hemorrhage hypotension, tachycardia.