Treatment Goals 1. Subdural, epidural, or intraparenchymal lesions must be excised or drained. Hydrocephalus should be treated. A polyene antibiotic which binds to ergosterol, the principal steroid in the fungal cell membrane, and increases the permeability of the cell membrane . It may also act as an immunoadjuvant enhancing cellular and humoral immunity.
High concentrations are fungicidal, whereas low concentrations are fungistatic.
May be used clinically with flucytosine synergistically. Total dose of 2-6 grams . Adverse effects include the following. Fever, nausea, vomiting, headache . Renal failure .