The use of anti cholinergics with codeine can produce paralytic ileus. Dosage should be adjusted according to the severity of pain. Tolerance to codeine can develop with continued use and should be kept in mind. Single doses Max. Lightheadedness, dizziness, sedation, shortness of breath, and vomiting can also occur.
Effects are more prevalent in ambulatory than non-ambulatory patients.
Some side effects may be alleviated if the patient lies down. At high doses, codeine can cause respiratory depression. Physicians' Desk Reference . Lippincott's Nursing Drug Guide . Compendium of Drug and Patient Info .