Even nature shudders in disorder because of one sin by the first man. That is absolute responsibility and accountability. Only the gospel can enable man to accept such awesome responsibility. This responsibility is the exact point where Paul begins his gospel message in Romans 1. Failure to submit to Him brings two immediate consequences.
Life becomes a jumbled jigsaw puzzle.
They lose the big picture. Then the second result swiftly follows. They drift morally and spiritually. Since God is absolute, man is his helpless dependent. The moral consequences of ignoring this dependence are as certain as the law of gravity.