After data entry, sites will be polled by fax on a quarterly basis to update the data and exam forms. Data entry will be performed at the NARC coordinating center. Analysis will be performed by Constantin Yiannoutsis at the Harvard School of Public Health. Sites will be reimbursed for cost of radiologic tests required only for this protocol. Since brain and spine MR would be required for the routine care of these patients, these should be paid by the patient's routine health care system.
Investigators receive support for the effort of participating in the study.
The patients will receive routine, aggressive HIV therapy. There is no specific intervention for the trial. There is no alternative therapy demonstrated to provide benefit to such patients. Thus, the natural history will be attained using current state of the art therapy, after thorough evaluation for alternative treatable causes for neurologic dysfunction. To facilitate this effort we will email each investigator a visit schedule of quarterly dates based on the enrollment date identified on the entry form.