MTIC methylates specific guanine-rich areas of DNA that initiate transcription, leading to cytotoxicity and antiproliferative effects. Rapidly and completely absorbed after PO use.
Food reduces the rate and extent of absorption.
Metabolized by hydrolysis. Excreted mainly in the urine. Treat adults with refractory anaplastic astrocytoma, i.e., those at first relapse whose disease has progressed on a drug regimen containing a nitrosourea and procarbazine. Safety and efficacy have not been determined in pediatric clients. Convulsions, hemiparesis, dizziness, abnormal coordination, amnesia, insomnia, paresthesia, somnolence, paresis, ataxia, anxiety, dysphasia, depression, abnormal gait, confusion.