Our work is focused on the quantification and improvement of the cellular fluxes necessary for overproduction of metabolites. This is done by molecular and physiological means and carried out in close connection with industrial and international collaborations. The current research group consists of technicians, postdocs, PhD students and undergraduates.
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Selected examples of research activities with key references are given below. We have found that in vivo a split pathway of L-lysine synthesis operates in C. glutamicum . This luxurious synthesis pathway serves to ensure the reliable provision of the lysine precursor diaminopimelate, which is an essential building block in the mureinsacculus. By overexpression of individual biosynthesis genes such as lysC or dapA , the lysine formation in a production strain can be considerably improved. We recently succeeded in cloning the L-lysine export carrier.