Measurements of electrical activity within the nerves indicated that they were conducting signals in a manner similar to healthy animals. Comparable results were seen in rats. High sugar levels destroy blood vessels that then become leaky, and reduce blood flow. Poor circulation leads to irreversible nerve damage throughout the body. Deterioration of nerves in the legs, feet and hands can make injuries more likely because individuals are less sensitive to pain.
Foot ulcers are particularly common in diabetics, and can be so severe that amputation is required.
The rate of leg amputation in diabetics is 15 times higher than in non-diabetics. While animal models do not mimic all aspects of the human disorder, this study does suggest that the potential of VEGF therapy for treating irreversible nerve degeneration in humans should be explored. . . . Schratzberger, P. et al . Reversal of experimental diabetic neuropathy by VEGF gene transfer.