Papule is painful and gradually hardens. Human infections are generally self limiting and resolve after 2 to 4 weeks. Some cases may progress to regional lymphadenitis, severe cutaneous eruptions or ocular lesions. Occupational hazard associated with handling sheep or goats. Humans, sheep, goats, domestic camelids and wild ungulates.
Human cases resolve without treatment.
Transfer of infectious agent high when exposed to infected sheep, some accounts of human to human spread. Monitor for symptoms, confirmation by histopathological identification of maculopapular lesion, isolation of virus. Laboratory infections are rare. Numerous cases acquired during the vaccination of sheep with live attenuated animal vaccine. Lesion fluid, crust or tissue of infected host.