The blastema replaces structures appropriate to its proximodistal position. The molecular basis is not understood but proximodistal identity in newt blastemal cells may be respecified by signaling through RA receptor isoform. The Development of Crustacean Limbs and the Evolution Of Arthropods. Niswander, L . BMP-2 Have Opposite Effects on Limb Growth.
Limb development is dependent on epithelial mesenchymal interactions.
UC Irvine Researchers Discover New Technique for Analyzing Crucial Cell Activity in Limb Regeneration. UCI Developmental Biology Center . Authors of the study at UC Irvine developed an effective method of studying the function of the specific genes necessary for limb regeneration in salamanders. This finding may ultimately provide key information leading to new approaches for the treatment of such ailments as spinal cord injury, deep wounds and burns. Stability of Positional Identity of Axolotl Blastema Cells-Invitro.