II mRNA promoter, polymerase II and III snRNA promoters, and a typical polymerase III promoter.
Gene expression is regulated largely at the level of transcription.
To understand the determinants of RNA polymerase specificity, we are characterizing the trans -acting factors required for the transcription of the RNA polymerase II and III snRNA genes. We want to understand how the short transcripts are generated. We have purified a factor that binds to IST and may therefore be involved in the formation of the short transcripts. We are characterizing the biochemical activities of this factor. Selected Publications Ford, E., M. Strubin, and N. Hernandez.