Michael Goy is Director of the Immunoassay Core Facility of the Center for Gastrointestinal Biology and Disease, a member of the Curriculum in Neurobiology , and an acoustically correct Triangle-area guitarist. Localization of GCA, GCC, and guanylin mRNA by in situ hybridization. Guanylin, an endogenous ligand for C-type guanylate cyclase, is produced by goblet cells in the rat intestine. Nitric oxide and peptide neurohormones activate cGMP synthesis in the crab stomatogastric nervous system. Purification and Cloning of a Uroguanylin-like Peptide from Rat Duodenum.
Low salt intake down-regulates the guanylin signaling pathway in rat distal colon.
Uroguanylin is expressed by enterochromaffin cells in the rat gastrointestinal tract. Natriuretic peptide receptor 1 expression influences blood pressures of mice in a dose-dependent manner.