We are also investigating the hypothesis that TGF- , a potent growth inhibitor for hepatocytes, is a primary restraining influence on liver regeneration and the development of cancer. Guanylyl cyclase C is up-regulated by nonparenchymal cells and hepatocytes in regenerating rat liver. Carver RS, Sliwkowski MX, Sitaric S, Russell WE Insulin regulates ErbB3 and heregulin binding in rat hepatocytes. Hepatic expression of ErbB3 is repressed by insulin in a pathway sensitive to PI-3 kinase inhibitors. Hepatic expression of ErbB3 is repressed by insulin in a pathway sensitive to PI-3 kinase inhibitors.
Liver regeneration is delayed in urokinase-deficient mice.
Peschon JJ, Slack JL, Reddy P, Stocking KL, Sunnarborg SW, Lee DC, Russell WE, et al. An essential role for ectodomain shedding mammalian development. For questions or comments about this site, please contact the webmaster.