This loss of function occurs before the PMN can be recognized as apoptotic and be removed by phagocytic cells. We are investigating how can apoptotic signaling pathway involving ceramide and PKC delta can change beta 2 integrin mediated adhesion. We have identified an apoptotic pathway that controls PMN adhesion to endothelial cells. This pathway offers potential new targets that control the recruitment of PMN to sites of inflammation. Publications S. Greenstein, J. Barnard, K. Zhou, M. Fong, B. Hendey.
Fas activation reduces neutrophil adhesion to endothelial cells.
Journal of Leukocyte Biology. In Vitro Model of Tumor Angiogenesis. In Vitro Cell. Everitt EA, Malik AB, Hendey B. Fibronectin enhances the migration rate of human neutrophils in vitro. Journal of Leukocyte Biology.