High sodium intake causes more lithium to be excreted. Low sodium intake will cause the kidney to retain lithium, raising blood levels. Drug damages mucosal surface. Medication induced mucosal damage by antineoplastic drugs may cause decreased nutrient absorption. This may cause vitamin B6 deficiency and peripheral neuropathy unless a B6 supplement is also prescribed.
Drug decreases the urinary excretion of nutrients .
Thiazide diuretics increase excretion of most electrolytes, but decrease excretion of Ca due to renal reabsorption. This effect may cause a hypertensive crisis, which can be fatal. Caffeine is a stimulant which counteracts the antianxiety effects of tranquilizers. Diet counteracts the effect of the drug . Drug may be secreted into the saliva .