A reduced threshold to suction-induced blister formation has been reported. Prominent acral accentuation of these lesions suggests a susceptibility to trauma-induced changes, but the definitive explanation awaits elucidation. No significant morbidity is associated with this condition unless secondary infection occurs. The reported age of onset ranges from 17-84 years. Blisters occur spontaneously and abruptly, usually without known antecedent trauma.
Lesions tend to be asymptomatic, although mild discomfort or burning has been described.
Blisters heal spontaneously within 2-6 weeks of onset. Bullosis diabeticorum presents as tense blisters arising on nonerythematous skin. Elevated levels may indicate porphyria cutanea tarda. Levels reportedly are normal in bullosis diabeticorum. No primary immunologic abnormality exists.