Screening pools in parallel with the same probe is cheaper. There are constraints on pool sizes. If a pool contains too many different clones, then positive pools can become too dilute and could be mislabeled as negative pools. Consideration of similar factors predate the Human Genome Project and they lead to the development of nonadaptive group testing. A nonadaptive group testing algorithm is sometimes referred to as a one-stage algorithm.
Every parallel algorithm is nonadaptive.
Advantages The library screening methods of the invention are extremely efficient. They have a zero probability of yielding a false positive. They give control over the pool sizes. Patent Status Additional information is available under terms of a Confidentiality Agreement .