Males are lazy most of the time, but when it's time to get active, they're more rambunctious than the females. Females dance around the home on their toes like cats while the males have heavy steps and stomp like small dogs. Female ferrets get very possessive of squeaky toys as if they were crying babies. Males could care less about the squeaking and often move away. Females are fairly fidgety and usually do not like to be held for extended periods of time.
Males are far more likely to accept the pampering.
Females consume less food and water and also produce less waste in your litter box than males. Males require a little more cage space and possibly even a large litter box. Females feel more delicate when being held while the males feel heavier and more muscular. Males and females also pose differing logistic and security concerns. Males can get to places females might not because they are stronger climbers, higher jumpers and can open or move heavier items.