Sometimes the appearance of blood changes are delayed so that repeat tests may be necessary to support the diagnosis. Usually, the antibodies are present in sufficient numbers by as early as day four, but sometimes not until day 21 of the illness. In the absence of positive tests, mononucleosis may be diagnosed on symptoms alone. Since mono is caused by a virus, it is not susceptible to antibiotic therapy. Rest, lots of fluids and a well-balanced diet are recommended.
Drug treatment is targeted to specific symptoms and individual experiences.
Ibuprofen is given for relief of headache, muscle pains, chills and fever. Warm, salt water gargles are recommended for sore throat. Corticosteroids are sometimes used if symptoms are severe enough to cause breathing difficulties. Sometimes bacterial infections such as strep or sinus infection can be present along with mono. If this is the case antibiotics can be helpful in treating the bacterial infection.