Protein in grey with bound GDP shown in color.
Magnesium is in green.
Most signal transduction events in cells are based on signal dependent conformational changes in key proteins. We are interested in understanding how different protein conformations are generated in response to signal and how these conformations are then recognized by other proteins. These proteins have been implicated in control of cell division and actin organization. My work has always focused on molecular recognition of biomolecules of one sort or another. When I moved to the Tom Kerppola's lab at the University of Michigan, my focus shifted to DNA-binding proteins.