Due to hemoglobinemia, the hemoglobin estimation may be unreliable. Similarly the parasite count may not represent the actual parasite load. There is methemoglobinuria and heavy albuminuria. Renal function gets affected and the urea and creatinine levels rise. There is increase in the levels of unconjugated and conjugated bilirubin as well.
Hepatic failure can occur in severely ill patients and is of grave prognosis.
Treatment is directed towards anemia and renal failure. Renal failure can be treated conservatively by careful fluid-electrolyte management and use of diuretics like furoscemide. Dialysis must be considered in patients who do not respond to conservative treatment.