There have been studies to limit the collection of fat in the body. Exercise and diet have been shown to reduce these fat accumulation syndromes. There is less knowledge on how to manage the loss of fat in certain areas. Managing stress and depression probably has an effect on the overall well-being and may enhance the immune system. People who are under a lot of stress or suffering from depression have more trouble adhering to their treatment regimen, resulting in an increased risk of drug resistance.
Good nutrition is also very important.
Although it is very difficult to prove in clinical trials that these interventions are effective, I have little doubt that they enhance the patient's overall outcomes. I think if people are going to take home anything about the toxicities, it would be the realization of how much we still don't know, and that we need to appropriately counsel patients with the appropriate data, and have the proper treatment despite these concerns. I personally suggest choosing the best regimen for each patient, despite the limitations, as opposed to being frightened and eluding therapy completely. Dr. Daar, thank you for joining us. WebMD members, please join us every Thursday at 9 pm EDT here in the AIDS Update Auditorium for our live weekly event.