Since the prevalence of both pernicious anemia and gastric cancer is higher in individuals of blood group A, and duodenal ulcer in those of group O, a hypothesis relating blood-group effects to acid secretion naturally followed. Studies in younger healthy subjects have given conflicting results. Another approach has been to study possible associations between ulcer symptoms and prognosis and the ABO blood-group and secretor characteristics. The same kind of error may well be present in data collected on secretor status, and an unselected consecutive ulcer series will be required to solve these problems. B. But simple comparisons of serum isoenzyme patterns in healthy individuals and patients with gastric cancer are impossible, for the presence or absence of the intestinal isoenzyme in the blood seems to depend greatly on diet.
Fat ingestion seems to stimulate the appearance of the intestinal isoenzyme in the serum.
Aird, I., Bentall, H. H., Mehigan, J. A., Roberts, J. A. F. Br. Aird, I., BentalI, H. H., Roberts, J. A. F. ibid. Clarke, C. A., Cowan, W. K., Edwards, J. W., Howel Evans, A. W., McConnell, R. B., Woodrow, J. C., Sheppard, P. M. ibid. Roberts, J. A. F. Br. Roberts, J. A. F. Br.