Conditioned through culture. And hence pain too. Nirvana is not heaven on earth, nor beyond rebirth. Ever-present happiness is a delusion. Natural suffering from natural pain continues beyond enlightenment.
General happiness is the goal and lived result of an enlightened life.
Serene enjoyment in a balanced way is the unsought result of religious practice. Everlasting Nirvana is a delusion. There is nothing preserved beyond death. And no rebirth, nor any continuity. Grasping arises out of our evolved sentience, i.e. conscious striving.