Frizzled proteins are seven-transmembrane receptors. There is biochemical and genetic evidence that Frizzleds act as receptors for Wnt proteins, in particular in the case of Frizzled and Dfrizzeld2 interacting with Wingless in Drosophila. Little is known about the mechanism of signaling. Ca release and PKC activity. Tables assembled with help from Hester Mary Wain Ph.
Genome analysis is included.
The remaining frizzled family members have not been mapped in humans.