Most active during late G 1 and early S stages. Ophthalmic solution used as an adjunct to surgical excision to treat primary or recurrent pterygia. Thrombocytopenia, coagulation disorders, increase in bleeding tendency due to other causes. Additional Side Effects Severe bone marrow depression, especially leukopenia and thrombocytopenia. Pulmonary toxicity including dyspnea with nonproductive cough.
Extravasation causes severe necrosis of surrounding tissue.
Respiratory distress syndrome in adults, especially when used with other chemotherapy. Severe bronchospasm and SOB when used with vinca alkaloids.