Lecture 2 hours, P.J. Dolphin and W.C. Breckenridge. The plasma lipoproteins are ordered macromolecular complexes of lipids with specific proteins which program the metabolic fate of the lipid component. The levels and distribution of lipoproteins within the blood are intimately connected with the genesis and regression of atherosclerotic vascular disease. The structure of lipoproteins at the physicochemical level, their biosynthesis, assembly and secretion are considered. Emphasis is placed upon the interpretation of original experimental data reported in the current literature.
Evaluation is based upon a mid-term essay and a final examination.
3200 and 3300 or equivalent. Interpretation of experimental data is emphasized. This class examines many of the interesting biochemical reactions in which RNA directly participates. Lecture 3 hours, P. Liu and W.F. Doolittle. This course discusses the organization of genes into genomes.