For the histopathologist, fibrous tissue may become more apparent from passive collapse and condensation of preexisting fibers. Within the space of Disse, fibrous tissue accumulates around the sinusoids and obstructs the free passage of substances from the blood to the hepatocytes. Venous resistance across the liver increases from portal vein branches to sinusoids and finally to hepatic veins. All three routes can be involved. Congenital hepatic fibrosis thus presents as portal hypertension with preserved hepatocellular function.
Histologic diagnosis depends on examination of a liver biopsy.
Because fibrosis is a sign of hepatic injury, its management is usually directed at the underlying cause. All rights reserved.