After control of infection is achieved, maintenance therapy with fluconazole appears effective. Although it is now widely used to treat primary coccidioidomycosis there is no study done yet to show its effectiveness. Ketoconazole, an oral fungistatic drug has also been used in milder cases of disseminated disease involving bone, skin, and non-cavitating pneumonia. HIV-infected patients with coccidioidomycosis should be treated with amphotericin B initially. Dissemination is very high in this group.
Maintenance therapy is lifetime with fluconazole.
Complement fixing IgG antibodies appear after IgM precipitins. When and how to treat coccidioidomycosis.