Laboratory staffs Prof. Ken-ichi SUGA, D. Eng. Biochemical engineers are required to possess an integrated knowledge of governing biological properties and principles of chemical engineering methodology and strategy. By focusing on pertinent fundamental principles in biological engineering sciences, new syntheses for bioprocess design, operation analysis, optimization and control will be accomplished. The following topics are currently being studied in the Laboratory.
Engineering approaches to animal cell culture .
Analysis of antibody production in hybridoma cell culture based on energy metabolism using metabolic engineering. . The selection and stability for recombinant CHO cell line expressing human GM-CSF in gene amplification. . The effect of culture conditions on the glycosylation in hybridoma antibody production. Bioprocess design, operation analysis, optimization and control .Development of the on-line control system of glutamic acid fermentation. Downstream processing .Fundamental studies on the nature of the interaction between antibodies and antigen using single-chain Fv.