Biology, including an advanced course, Chemistry, Physics, and other natural sciences are featured in the Science Department curriculum. American History, American Government, Economics, Practical Law, Social Problems, Senior Geography, Current Issues, and other courses comprise the studies in Social Science. The Language Department offers courses in Spanish and German at a variety of levels. Beyond the academic offerings at the Barnesville Schools, students are able to participate in a wide range of co-curricular activities. The athletic programs at the school include sports such as volleyball, basketball, track, golf and cheerleading for female students.
Male students have football, wrestling, basketball, track and golf as athletic activities.
These athletic teams are members of the powerful Heart O'Lakes Conference. Co-curricular activities are also offered in the areas of fine arts and academics. Barnesville students are enrolled in programs such as Swing Choir, Jazz Band, Debate, Speech, One-Act Play, school musicals and the National Forensic League. Academically, students have been involved in Knowledge Bowl, regional Math Track Meets,the National Geographic Society Geography Bee, the Citizen Bee, Language Club, Arts Club, and a number of other programs. The Barnesville School system has a proud history of participation in the AFS international student exchange program.