Many cases are so mild that some people recover without knowing they have had mono. In mild cases you may be able to go about your usual activities. If symptoms are severe, bed rest may be necessary for a few days. Complications such as persistent fever or jaundice may prolong your recovery. Some weakness and tiredness may persist up to two months after the acute symptoms disappear.
Extra rest is needed for fatigue.
Antibiotics are not effective in treating mono. The illness is caused by a virus and antibiotics are effective only against bacteria. Antibiotics could be used to treat a co-existing disease such as strep throat. If you have been diagnosed as having mono, it is not necessary to isolate yourself from other people. Good hygiene is all that is required.