Includes a tutorial in presentation methods. Ph.D. Doctoral thesis research. 3 Protein and Nucleic Acids Biochemistry Coverage of the basics of nucleic acid and protein biochemistry. An integrated approach to the applications of NMR, X-ray crystallography, and mass spectrometry in structural biology. 2 Contemporary Organic Synthesis I Survey of the most important preparative reactions in organic synthesis.
Emphasis is placed on mechanism and stereochemistry where appropriate.
Introduction to retrosynthetic analysis. Reading assignments from primary and review literature. Discussion, primarily from recent and current literature, of selected compounds of medicinal importance. Biochemical studies of affinity probes, immunoconjugates, prodrugs, liposomes, membrane mimetics, and chemically-modified polysaccharides, peptides, and nucleic acids are included. Discussion and problems taken from recent literature.