Competitively inhibits gastric acid secretion by blocking the effect of histamine on histamine H 2 receptors.
Food increases the bioavailability.
Pathologic hypersecretory conditions such as Zollinger-Ellison syndrome and systemic mastocytosis. Short-term treatment of active, benign gastric ulcers. Maintenance of healing of gastric ulcers. Gastroesophageal reflux disease, including erosive esophagitis. Maintenance of healing of erosive esophagitis.