Sebum of the patients with acne contains excess of free fatty acids. This excess sebum accumulates in hair follicles. Later it gets blocked and gives rise to inflammation due to bacterial infection. If the sebum glands are unduly sensitive, then even with the normal level of hormones the sebum secretion may increase. In young women acne usually flares up during their menstrual cycle, which naturally coincides with the hormonal changes.
Keratin is a protein, which is the main constituent of skin cells.
Worn out Keratin is a cleavage by keratinsation, which is facilitated by enzyme keratinase. Due to abnormal and increased keratinisation the flow of sebum at the outlet of the pilo-sebaceous follicle gets blocked. It breaks down tryglyceride in sebum to free fatty acids and triggers off the inflammatory process. According to Ayurved, acne are the papules resembling the sprout on the bark of 'Shalmali ' tree, appears on the face in adolescents. Increased 'kapha and vata dosha' and 'rakta and meda dhatu ' are involved in causing this disease.