It used to be very popular to do drug holidays. It ended up All right, levodopa. Levodopa is rapidly converted to dopamine in the periphery by dopamine decarboxylase. Now two things happen when that happens. Number one is you get sick.
Dopamine causes nausea.
So it can t get in to do you any good. You need 75 mg to 100 mg of carbidopa to inhibit the full daily supply of dopamine decarboxylase. There s not enough carbidopa in that tablet. So low dose Sinemet is somewhere between 100 and 500 mg a day. Medium dose is between 600 and 1,000 and high dose is anywhere from Sinemet.