The effects of being in free fall are identical to the effects of being in deep space. Alas, they are destined to spend their days in their locked rooms. Without outside information, no experiment they can perform in their rooms will distinguish between deep space and free fall. Orbits, like most space travel, are a type of free fall. Many people think that astronauts are weightless because there is no gravity in space, but this is far from true.
Gravity is everywhere in our universe.
Understanding free fall is the key to understanding weightlessness. 1996, National Air and Space Museum, Smithsonian Institution.