The body does not produce enough collagen, a protein necessary for building connective tissue, including bone.
Frequent fractures interfere with normal bone growth.
Those affected may be abnormally short or have other deformities of the skeleton . Deformation of the ear bones may cause at least partial deafness . Collagen is found throughout the body, not just in bone and connective tissue. It is a component of the whites of the eyes, and defects may cause the whites to be abnormally translucent and bluish in color. And collagen gives strength to the walls of the blood vessels, so the disease may lead to dangerous bleeding.