Changes in extremities include swelling and induration of the hands and feet. Other associated findings not included in the major diagnostic criteria are often present in patients with Kawasaki disease. These are subdivided into cardiac, noncardiac and laboratory findings. The markers of KD are the cardiac manifestations. Patients may present with tachycardia and gallop rhythms.
Electrocardiographic changes are nonspecific.
Abnormalities include aneurysms and diffuse ectasia. Patients with giant aneurysms are at greatest risk for developing coronary thrombosis, myocardial infarction or stenosis. These aneurysms usually become apparent 1-3 weeks after the onset of fever. See Table 3 for risk factors in patients with KD for coronary aneurysms. Prompt diagnosis is optimal because patients untreated within first 10 days of illness have increased risk of developing coronary artery aneurysms.