Over 3 Years Reginster, Deroisy, Paul, Lee, et al.
Glucosamine sulfate is a component of normal human cartilage.
It is sold in the U.S. as a nutritional supplement but is approved in Europe as a drug . This study investigated the potential for prolonged administration of glucosamine to slow progression of OA of the knee. Disease progression was assessed by measurement of joint space width obtained by extended view standing knee xrays. The average joint space width at study entry was 5 mm. The two groups were comparable for demographics and disease characteristics at baseline.