I will have to try much harder to remove purpose and meaning. It isn't so much that way in real life, but perhaps these writers have given us a key to understanding meaning because they instinctively know how to remove all of meaning. So I think I can create from this a working list from which to start. Both social context and spiritual context establish a meaning framework for life that we would not be able to develop by ourselves. Being without a framework would be like entering a game without knowing the rules.
Games are meaningless enough, but without rules are chaos.
None of the game would make any sense. So isolating a person from social context and all of these other things would be a good place to study. More modern character flaws are usually drawn as products of their environment. Characters that feel this isolated have a conflict as a fatal flaw that prevents them from linking into any of these factors that give life meaning. The only situation I can think of where this has happened to many people who have been able to report on their experiences is in concentration camps.