Collagenomas and elastomas generally present during the postpubertal period. In Buschke-Ollendorf syndrome, the skin changes may be delayed until adulthood. The nevus mucinosis may present at birth, during childhood, or in adolescence. Collagenomas have been associated with multiple medical syndromes. They also have been associated with Down syndrome.
Lesions typically occur in postpubertal period.
Increased numbers of lesions during pregnancy have been reported in a few patients. Shagreen patch is a collagenoma-variant associated with tuberous sclerosis, a disease inherited in an autosomal dominant pattern. Flesh-colored plaques of variable size are located primarily in the lumbosacral area. Shagreen patches can occur singularly or asymmetrically in limited numbers. Eruptive collagenoma - One of the acquired variants of collagenoma characterized by nodules similar to familial cutaneous collagenoma.