This progressive narrowing can cause blocked bile flow that can result in liver damage. About 75 percent of the cases diagnosed with the disease are men who are about 40 years of age. Most people do not have symptoms at the time of diagnosis and the disease usually progress slowly over 10 to 15 years. As the disease becomes more advanced, a person may complain of fatigue, itching, and fatty diarrhea. Upon further evaluation, vitamin A, D, and E deficiencies can be found along with elevated cholesterol and osteoporosis.
Liver biopsy is helpful in staging the severity of disease.
Currently there is no dependable treatment although studies continue with several medications. Liver transplantation is the treatment of choice and PSC is the fourth leading cause of transplantation. Wilson's Disease Wilson's Disease is a hereditary disorder of the liver that causes the liver to store excess copper. It effects 1 in 30,000 people and is detected between ages 3 and 40. If diagnosed promptly and treated consistently, the prognosis is good.