The ascorbate in these massive doses drastically reduces the incidence of allergic reactions to antibiotics. It seems that the reason patients have so high a rate of allergic reactions to drugs, especially antibiotics, is that they take them when they are sick. The free radicals activate the immune system. Clinically, massive doses of ascorbate usually prevent allergic reactions. Allergic reactions underway can be terminated abruptly with adequate doses of ascorbate.
Free radicals are an almost universal sign of damage to the body.
It would not do for the immune system to be taking off after every foreign macromolecule that enters into the body. Actually this is what frequently happens when one is chronically ill for long periods of time. The immune system is activated by the resulting free radicals. All this is a theory of mine to explain the observed facts but there is experimental evidence that the affinity of antibodies for their antigen is greater in an oxidizing redox potential. No one else seems to make anything of that fact.