Prepared and published by Update Software Ltd . All rights reserved. Cochrane reviews are regularly checked and updated if necessary. Although the etiology of endometriosis is unknown, several theories exist, the most popular of which is retrograde menstruation.
Endometriosis appears to be an estrogen dependent condition.
At the time of menopause, most endometriosis becomes quiescent. This hormonal dependency prompted researchers to seek agents which would suppress ovarian activity. The Cochrane Subfertility Review Group specialised register of controlled trials was searched. Eight trials were identified comparing a suppressive agent with danazol. Relevant data were extracted independently by two reviewers using the standardised data extraction sheet.