No medications are used to treat Best disease. If visual changes occur at any stage, then an earlier visit should be scheduled. Every 6 months to yearly Those patients in the atrophic stage should routinely use an Amsler grid. Changes in the central visual field should prompt an early visit to evaluate for choroidal neovascularization. The electrophysiology test usually is only necessary once to establish the diagnosis.
Initial results remain fairly stable during disease progression.
Perform fluorescein angiography at any visit when suspicion of choroidal neovascularization is present. Although uncommon, this complication can occur following the atrophic stage, and it can be responsible for further deterioration in visual acuity. A disciform scar may result. Prognosis for this disease is mixed. Some carriers will never phenotypically express their disorder.