When hypertension is treated, however, it has little effect on insulin resistance. According to the AHA, a patient with diabetes and hypertension has twice the risk for CVD as a patient who does not have both conditions. The prothrombotic state is a fairly new area of attention in insulin resistance. Patients with hyperinsulinemia have altered clotting mechanisms and are therefore predisposed to arterial thrombosis. Hyperuricemia Elevated uric acid levels have been associated with syndrome X abnormalities, insulin resistance and hyperinsulinemia.
Experts believe the link is renal handling of the uric acid.
Obesity and Physical Inactivity Insulin resistance can occur independently of obesity and sedentary lifestyle. Studies show that a patient who is not obese may possess the defects that occur in insulin resistance. 2,4 Modest weight loss and increased activity are helpful with these patients, as well as their obese counterparts. Therefore, obesity and sedentary lifestyle should be considered risk factors for insulin resistance. Sadly, obesity and inactivity are increasing.