Hypertrophic osteodystrophy causes lameness and extreme pain in young growing dogs, usually of a large breed. Great danes, German shepherds, dobermans, retrievers and weimaraners are examples of breeds that may be affected by this condition. It appears to occur in weimaraners as a vaccine reaction and this may also affect mastiffs and great Danes.
HOD usually shows up as an acute lameness, often seeming to affect all four legs simultaneously.
They may have a fever but this is not consistently present. They usually have painful swellings around the lower joints on the legs. Some puppies will die from this disease, some suffer permanent disability but many recover later. The disease is so painful that many owners elect to euthanize the puppy rather than watch it suffer, despite the reasonably good chance for recovery, long term. Affected dogs may be so ill that they refuse to eat.