Human umbilical vein endothelial cells were cultured on microporous membranes to achieve a monolayer. Freshly isolated neutrophils from healthy subjects were measured with a migration assay. This is similar to the situation after resorption in-vivo. In conclusion, epigallocatechin gallate was identified as a potent inhibitor of leukocyte migration through endothelial cell monolayers. The treatment of both cell types showed an additive effect.
Endothelial cells seem to be more affected than neutrophils.
Further clinical investigations are necessary to understand the potential clinical consequences.