Developing lesions are well defined, smooth, painless and easily moved around since they lie free over the deeper tissues. Clinical forms Cutaneous and subcutaneous. Prognosis and therapy Lesions are managed by surgical excision. Since frequent relapse occurs, the excision must be wide. Histopathology Nodules consist of subepidermal histiocytic granulomas that lie between the overlying skin and subcutaneous tissue.
Fibrous tissue is dispersed between large numbers of giant cells and histiocytes.
In older lesions, pyogenic infiltrates, parakeratosis, and acanthosis are present. Pseudoepitheliomatous hyperplasia and intraepidermal abscesses abscesses are absent. Each cell is connected to the adjacent cell by a narrow neck. Some yeast cells occur within giant cells and macrophages, but the majority surround these cells. Isolation Isolation of the fungus has never been achieved, except in mice foot pads.