There will be no doubt as to its origin. The sad fact is that only the urine from pregnant mares is used to produce Premarin . Often, pregnant mares are stallbound wearing a catheter bag to collect their urine for processing. Reports differ, some claim regular rotation of the mares for exercise and relief from the catheter, with generally decent care of the horses. Others report of abuse and intolerable living conditions with everything from chafing from the urine bags to crippling injuries.
Drug companies are far more concerned with their profit margin than the welfare of a few horses.
But it's more than just a few horses that are dying every year as a result of the production of Premarin . It is estimated that there are as many as 75,000 Premarin foals born each year to these pregnant mares. These foals are an unwanted byproduct of Premarin production and many end up going to slaughter. Imagine you have a huge barn full of horses. Now imagine for argument's sake that every horse in the barn is pregnant.