Scleroderma is chronic, which means it can last a long time. Generalized scleroderma may affect many parts of the body. Diffuse scleroderma develops more suddenly, with skin thickening throughout the body. Internal organs can also be affected. Usually skin creases disappear.
Extremities are sensitive to cold caused by emotional stress.
Although the cause is unknown, it is known that the body produces too much of a protein called collagen. Excess collagen is deposited causing thickening and hardening. Physical exam, medical history and lab tests which may include biopsy and blood tests. Although there is no cure, many different drugs can help control it. Joint protection to reduce stress on joints.