The Polymerization Problem . Miller experiments produce five times more unifunctional molecules than bifunctional molecules. The Polymerization Problem . Also, the alkaline conditions needed to form sugars are incompatible with acid conditions required to form polypeptides with condensing agents. A small fraction of wrong handed molecules terminates RNA replication, shortens polypeptides, and ruins enzymes.
Life requires catalysts which are specific for a single type of molecule.
Prebiotic polymerisation simulations yield random sequences, not functional proteins or enzymes. The origin of coding system of proteins on DNA is an enigma. So is the origin of the message encoded, which is extraneous to the chemistry, as a printed message is to ink molecules. A code cannot self-organize. The origin of machines requires design, not random energy.