Jesus is not praising people with objectionable personalities. At different times during our life, lack of wisdom gets us in hot water . That is not persecution for the sake of Jesus. Many times our self-righteous, holier than thou attitude, that has incurred the wrath of those in and out of the church. That's not what Jesus is talking about.
Fanaticism leads to persecution and fanaticism is never commended in Scripture.
A fanatic has excessive or un-reasonable enthusiasm and zeal. The question that's hard to answer is this. Ask 100 people and you will get 100 answers. Some people would say that going to church every Sunday is fanatical. When we define the Christian life by our religious activity we place ourselves in danger of becoming fanatical.