The Journal of Clinical Investigation Am. The Lab Mission of the laboratory Dr. Posada's research team is focused on dissecting the MAP kinase signal transduction pathways that regulate cell proliferation. Ms. Alyn Whelchel, Laboratory Tech. Smooth Muscle Proliferation - Increased proliferation of airway smooth muscle is one of the structural changes that takes place in the asthmatic airway. We are currently examining the signal transduction pathways that regulate the growth of airway smooth muscle.
Experiments involving receptor truncation and site-directed mutagenesis are underway.
The mechanisms employed by the endothelin receptor in stimulating cell proliferation are currently being explored. Activation of the ERK2, JNK1, and p38 MAP kinases by endothelin are major points of emphasis. Publications Tritton, T.R. and Posada, J. Signal transduction mechanisms in multidrug resistance. J. Cell Pharm. T.R. Protein kinase C in adriamycin action and resistance in mouse sarcoma 180 cells.