The PDQ editorial boards use a formal ranking system to help the reader judge the strength of evidence linked to the reported results of a therapeutic strategy. Stage III seminoma Stage III seminoma is usually curable. Standard Radical inguinal orchiectomy followed by multidrug chemotherapy. A modified regimen has been used in children. Residual radiologic abnormalities are common at the completion of chemotherapy.
Many abnormalities gradually regress over a period of months.
Some clinicians advocate empiric radiation of residual persistent abnormalities or attempts to resect residual masses 3 centimeters or more in size. Either approach is controversial. In some series, surgical resection of specific masses has yielded a significant number with residual seminoma that require additional therapy. Nevertheless, other reports indicate that size of the residual mass does not correlate well with active residual disease, most residual masses do not grow, and frequent marker and CT scan evaluation is a viable option even when the residual mass is 3 centimeters or more. In some patients fertility has returned following the use of chemotherapy.