Water exchanges should not be carried out too quickly. Infected tadpoles should be fed with medicated feed for 1 week and it is recommended that water is exchanged daily. Internal signs are haemorrhage in most of the visceral organs. Blood and yellow fluid are often found in the abdominal cavity. This disease is a good example of a stress-related disease, overcrowding and poor water quality seem to be the major factors involved.
Internal signs are enlargement of the digestive tract.
Opalina, Protoopalina, Balantidium, Trichomonas and Nyctotherus cordiformis are ciliate protozoa often found in the digestive tract of diseased frogs. As for treatment of indigestion in tadpoles. The intestine is enlarged and the lumen contains a clear liquid and undigested food. Protrusion of posterior intestine from cloaca may be found in some affected frog. This disease is caused by food poisoning.