Microscopic Pathology - The microscopic pattern is of groups and bundles of smooth muscle fibers intermixed with fibrous connective tissue and arranged in a whorled fashion. Mitoses are rare. Degenerative Changes Degenerative changes are reported in approximately two-thirds of all specimens, but most of them have no clinical significance. They occur secondary to postmenopausal atrophy, infection, alterations in circulation or malignant transformation. It is the most common degenerative change.
Liquefaction follows extreme hyaline degeneration.
It can be eventually a sequel of necrosis. Hyaline areas are replaced by a soft, gelatinous material. It occurs usually in large tumors, with impaired arterial input. Lipids are found inside smooth muscle fibers. The process is usually accompanied by pain, but is self-limited.