Tolerance, psychological and sometimes physical dependence can develop. Continued high doses can cause heart problems, malnutrition, death. Tolerance and physical dependence can develop.
Effects are unpredictable convulsions, coma, and death are possible.
Nasal membranes may be destroyed. Smoking may cause lesions in lungs. Tolerance, physical and psychological dependence can develop. Depressants taken in combinations or with alcohol are especially dangerous. Longterm use may cause moderate tolerance, psychological dependence.