Pleural effusion and empyema mentioned in surgical pathologic report from 1995. Review of outside material. EBER in-situ hybridization was performed in our laboratory on both biopsy specimens. Focal areas of necrosis are present, and these are associated with a significant influx of neutrophils.
Focal vasculitis is present in the lesion.
No Reed-Sternberg cells are seen. The mediastinal lymph node is largely replaced by a lymphomatous infiltrate similar to that described in the lung biopsy. However, there is less necrosis in this specimen, and some microscopic fields consist predominantly of large cells. EBER stains are strongly positive, and more so than in the lung specimen. Insufficient unstained slides have been received for immunophenotypic studies, but tissue was sent for flow cytometry and gene rearrangements in the referral hospital.