People born with joint abnormalities are more likely to develop osteoarthritis. Some people have an inherited defect in one of the genes responsible for making collagen, a major component of cartilage. This causes defective cartilage, which leads to more rapid deterioration of joints. Obesity increases the risk for osteoarthritis of the knee. Maintaining ideal weight or losing excess weight may help prevent osteoarthritis of the knee, or decrease the rate of progression once osteoarthritis is established.
Injuries contribute to the development of osteoarthritis.
For example, athletes who have knee-related injuries may be at higher risk of developing osteoarthritis of the knee. In addition, people who have had a severe back injury may be predisposed to develop osteoarthritis of the spine. People who have had a broken bone extending into the joint margin are prone to develop osteoarthritis in that joint. Overuse of certain joints increases the risk of developing osteoarthritis. For example, jobs requiring repeated knee bending increase the risk for osteoarthritis of the knee.