The structure is constructed of rigid tapered-steel bents with no interior columns. Purlins, girts, and wind columns are constructed of cold-formed steel. The exterior wall and roof sheeting are ribbed metal with fiberglass insulation. The roof slopes down to the north and south from the centerline. The floor is an on-grade slab.
Interior partitions are gypsum board over metal studs and prefabricated modular units.
A loading dock is located in the southwest corner. Building 442 was originally used to launder uranium-contaminated protective clothing from Building 444. When Building 442 operations changed to filter testing, laundry operations were moved to Building 778. The final use of the structure included a filter-testing laboratory and storage area for high efficiency particulate air filters and respirator cartridges. Radioactive sources were used in some of the test equipment.