Not effective against obligate anaerobes.
Food decreases the absorption of norfloxacin.
Uncomplicated UTIs caused by Escherichia coli, Klebsiella pneumoniae, Enterobacter cloacae, Proteus mirabilis, P. vulgaris, Pseudomonas aeruginosa, Citrobacter freundii, Staphylococcus aureus, S. epidermidis, Enterococcus faecalis, Enterobacter aerogenes, S. saprophyticus and S. agalactiae. Complicated UTIs caused by Enterococcus faecalis, E. coli, K. pneumoniae, P. mirabilis, P. aeruginosa or Serratia marcescens. Prostatitis due to E. coli. Hypersensitivity to nalidixic acid, cinoxacin, or norfloxacin. Lactation, infants, and children.