Propofol may be stored at room temperature. Propofol pharmacokinetics is characterized by a three compartment linear model, with fast distribution into the tissues, rapid metabolic clearance, and a slow return to the peripheral compartment. Following the initial bolus dose, propofol equilibrates between the plasma and the brain. Plasma levels, however, decline quickly as a result of high metabolic clearance and prompt distribution to the tissues. These properties account for propofol's rapid onset and short duration of action.
Distribution time decreases as tissues equilibrate with plasma and become saturated.
The last phase is not thought to be clinically significant. Clinically, maintenance of adequate sedation requires a constant infusion of propofol. Discontinuation of propofol anesthesia usually results in a rapid decrease in plasma concentrations and prompt awakening. Longer anesthesia cases or sedation in the intensive care unit may produce higher plasma concentrations and thus prolong awakening time. Propofol is metabolized via hepatic conjugation to inactive metabolites which are excreted in the renal system.