The resulting antigenic peptides reach a specialized major histocompatibility complex class II compartment, in which class II molecules encounter peptides. Peptide-loaded class II complexes are then transported to the cell surface for sampling by T helper cells. The internalization and routing of antigens play a decisive role in their processing and presentation of T lymphocytes, which ultimately determine the effectiveness of the immune response. Research focuses on understanding the antigen processing and presentation pathways of protein toxins and on studying the molecular mechanisms of Tcell anergy caused by bacterial superantigens and other disease states. Broad and complex investigations require advanced knowledge of theory and methodology in many areas of biological science.
Emphasis is placed on cellular biology, cellular and molecular immunology, and molecular biology.
Research centers on understanding molecular and cellular mechanisms of action of protein toxins, and on developing new and innovative methods for evaluation and construction of new and improved vaccines against biological protein toxins. You may use the following form to add this opportunity to your database or check all the opportunities you have saved in your database. To do that, you need to provide the correct username and password first.