Four patients received adjuvant chemotherapy and six patients received adjuvant hormonal therapy. With a median follow-up of 8.4 years, nine of 18 patients were alive and free of disease. Aggressive treatment is warranted in this favorable subgroup of patients. Provincial Breast Disease Site Group. To make recommendations about the use of breast irradiation in women with early stage invasive breast cancer following breast conservation surgery.
Local control is the primary endpoint of interest.
Earlier drafts of the evidence-based recommendation were reviewed, discussed and approved by the Breast DSG, which comprises medical oncologists, radiation oncologists, surgeons, epidemiologists, pathologists and a medical sociologist. There was no participation by a community representative in the development of this guideline. All of the 5 RCTs showed a significant decrease in local recurrence rates among patients receiving radiotherapy. Despite the effect on local recurrence, no difference in survival was detected in any of the 5 trials. Most of the patients with local recurrence in these trials underwent mastectomy.