May act by subunit modulation of the GABA receptor chloride channel macromolecular complex resulting in sedative, anticonvulsant, anxiolytic, and myorelaxant properties. Although unrelated chemically to the benzodiazepines or barbiturates, it interacts with a GABA-benzodiazepine receptor complex and shares some of the pharmacologic effects of the benzodiazepines. Specifically, it binds the omega-1 receptor preferentially. Rapidly absorbed from the GI tract.
Food decreases the bioavailability of zolpidem.
Impaired motor or cognitive performance after repeated use or unusual sensitivity to hypnotic drugs may be noted in geriatric or debilitated clients. Closely observe individuals with a history of dependence on or abuse of drugs or alcohol. Safety and efficacy have not been determined in children less than 18 years of age. The most common side effects following use for up to 10 nights included drowsiness, dizziness, and diarrhea. Headache, drowsiness, dizziness, lethargy, drugged feeling, lightheadedness, depression, abnormal dreams, amnesia, anxiety, nervousness, sleep disorder, ataxia, confusion, euphoria, insomnia, vertigo.