In search of the tumour-suppressor functions of BRCA1 and BRCA2. However, it is unclear to what extent such functions specifically suppress breast and ovarian cancer. Here we analyse what is known of BRCA gene function and highlight some unanswered questions in the field.
Gene therapy is a new alternative therapeutic approach.
16 gene therapy clinical trails are applied to ovarian cancer. A knowledge of basis concepts of gene transfer strategies, is needed to understand these different treatment strategies. Thus, the goals of this review are, first, to provide the basis concepts of gene transfer strategies to the obstetrician-gynecologist and second, to submit recent gene therapy clinical trials about ovarian cancer. An antibody assay predictive of BRCA1 mutations in ovarian tumors and normal tissue. Ten patients at risk for BRCA1 mutations were studied.