We have identified the site of Cyclin E cleavage and are now addressing the role played by the Cyclin E proteolytic fragments in apoptosis. Molecular modeling suggests that truncation converts cyclin E into a death effector molecule. Proc Natl Acad Sci. Genetic instability as a consequence of inappropriate entry into and progression through S-phase. Gene amplification in a p53-deficient cell line requires cell cycle progression under conditions that generate DNA breakage.
Ionizing radiation induces mitochondrial gene expression and activity.
Cell Growth Diff. Commitment to ionizing radiation-induced apoptosis.