The initial pattern of the developing vertebrate nervous system. The local cell interactions that control the differentiation of specific neural cell types, and the pathways of growing axons. The rule of adhesion molecule in axon guidance. The control of cell patterning in the embryonic central nerves system. Alteration of gene expression in mice, as a tool to study their role in axon guidance and pattern formation.
Gene knock out and transgenic technique are being applied.
That Promotes Neural Cell Adhesionand Neurite Extention. A., Control of floor plate identity and function in the embryonic nervous system. Accumulation of F-spondin in injured peripheral nerve promotes the outgrowth of sensory axons. F-spondin is expressed in somitic regions avoided by neural crest cells and inhibits neural crest migration in the avian embryo. F-spondin is required for accurate pathfinding of commissural axons at the floor plate.