If the fish were given I3C before or during cancer-causing chemicals, I3C protected them against cancer. It was only if huge amounts were given after cancer was in progress that problems occurred. From a scientific standpoint, these studies have little or no relevance to humans since fish metabolize chemicals very differently than humans. Rodents are a much better model for humans. In rodent studies, I3C inhibits cancer and stops DNA damage.
Humans are the best model yet.
In human studies, I3C neutralizes estrogen, reducing it to a less powerful form. In studies on human breast cancer cells, I3C works better than tamoxifen to stop growth. And in a test of 90 different potential cancer inhibitors, I3C scored at the very top. A majority of the data says I3C is powerful protection against cancer. Q A chain health food store claims that it is the only one selling the type of SAMe used in clinical studies.