A final pool of cells, Y , consists of replicating uninfected cells. Replicating infected cells, X, are killed at the same rate as are quiescent infected cells, I . U and Y are killed at the slow liver turnover rate. New free virus particles, pool V , are produced from infected cells. These can reinfect cells U or Y .
Free virus is cleared at a fixed rate per virion.
The quantity in brackets approximates the deficit in total cells, and power p controls the rate at which total cell count approaches its nominal level, C . Recruitment into replication phase becomes more intense as total cell count falls. 2 and k 1 are derived from others below. C' is slightly larger than C to account for normal liver cell turnover. 1 I , is multiplied by a function of total liver deficit.