While most patients survive to early childhood, respiratory problems can further shorten life. Weakness in leg, hip, shoulder, arm and respiratory muscles. Calf muscles are often enlarged. Disease progresses slowly. Wheelchair is often required by age 30.
Life span is unaffected.
Weakness in the tongue, hands or feet which slowly spreads to other parts of the body. A relatively mild form of spinal muscular atrophy, it has little impact on life expectancy. Fever, malaise or mild gastrointestinal distress followed somewhat later by blotchy rash on the cheeks. Swelling of the upper eyelid is also common. Disease progression and severity vary by individual.