Erectile dysfunction is a common problem in diabetic men.
Previous short-term studies have shown that alprostadil delivered by a transurethral system produces erections and restores sexual intercourse. We have now studied the clinical safety and efficacy of transurethral alprostadil delivered by this system over a 3-month period in diabetic and nondiabetic men. Key results are shown in the table below. In patients who responded at home, approximately 7 of 10 active drug systems resulted in sexual intercourse. Adverse effects, other than penile pain, were uncommon in the group as a whole.