The diagram is from a Hypertextbook at Colorado State University . It is located inside the nucleus of a cell. In androgen resistant conditions, there is an abnormality in this part of the receptor and therefore the cellular activity of the hormone is blocked. This diagram is also from Colorado State University . There are other examples of hormone resistant states.
Individuals can be resistant to thyroid hormone.
Attention deficit disorder may be related to thyroid hormone resistance. Resistance to parathyroid hormone has been recognized for 50 years. Fuller Albright was a brilliant endocrinologist who first described this in the late 1940's. M.D. Insulin resistance and its role in diabetes is a difficult and controversial topic. The original concept of insulin resistance referred to the clinical observation that some patients with diabetes required very large doses of insulin to lower their blood sugars.