Toxicity Hexane and related aliphatic hydrocarbons exhibit only slight acute toxicity by all routes of exposure. The liquid may cause irritation upon contact with skin or eyes. Ingestion of hexane or other hydrocarbons may lead to aspiration of the substance into the lungs, causing pneumonia. Prolonged skin exposure may cause irritation due to the ability of these solvents to remove fats from the skin.
Hexane is regarded as a substance with good warning properties.
Chronic exposure to hexane or other aliphatic hydrocarbons may cause central nervous system toxicity. Hexane has not been found to be a carcinogen or reproductive toxin in humans. Hydrocarbons of significantly higher molecular weight have correspondingly higher vapor pressures and therefore present a reduced flammability hazard. Carbon dioxide or dry chemical extinguishers should be used for hexane fires. Reactivity and Incompatibility Contact with strong oxidizing agents may cause explosions or fires.