These parents are also called carriers . The offspring have to be homozygous recessive to have the disease or condition. The enzymes compensate for the missing protein by doing more work than normal. When they are exposed to lower oxygen levels, they will experience some of the symptoms of the individual with sickle-cell disease. Autosomal Dominant Only one mutant allele needs to be inherited in these diseases.
Familial hypercholesterolemia is one such disease.
Although a heterozygous individual may be able to produce half the number of receptors needed to take in the lipoprotein, these are insufficient to handle the uptake of lipoprotein. The folk singer Woody Guthrie died from this disease. So far Arlo has not developed the disease and he is in his 50s. X-linked Diseases Males have only one X chromosome, so even a recessive allele will be manifested. For a female to inherit a recessive, X-linked disease she must receive one affected X chromosome from each parent.