DOK Version 4.200104 Complete description of the cell line that you requested. The dysplastic oral keratinocyte cell line DOK was isolated from a piece of dorsal tongue from a 57 year old man. The degree of dysplasia in the patient was described as mild to moderate. The cells show some stratification in confluent cultures and contain a keratin profile similar to the original dysplasia.
Growth is stimulated by hydrocortisone and inhibited by cholera toxin.
DOK cells are non-tumourigenic in athymic nude mice.