They inhibit the 3rd stage of cell wall synthesis. Bacillu antracis, C. Diphtheriae, Listeria monocytogenes. Pasteurella multiocida, Streptobacillium moniliformis, spirilium minor. Treponema pallidum, Leptospira. Ticarcillin, Carbenicillin f.
Irritant properties effect the peripheral nervous system.
Nephropathy - allergic rxn. Derived from Cephalosporium acremonium. Mechanism of Action - also inhibits the third step of bacterial wall synthesis, binds to specific proteins on the cell membranes, alters their permeability, inhibits protein synthesis and releases autolysins 3. Resistance - decrease in the bacterial cell wall permeability to antibiotics. Hematologic - neutropenia, leukopenia, thrombocytopenia.