The latter may require its discontinuance. Monitoring white blood counts every 2 weeks during the first three months of therapy is necessary. The standard dose is 250 mg PO q12h. The major indication for abciximab is as adjunctive therapy with heparin and aspirin for prevention of abrupt coronary vessel closure after angioplasty. Eptifibatide has been shown to be effective in patients with acute coronary syndromes and those undergoing percutaneous balloon angioplasty or atherectomy.
Dosing recommendations vary depending on the indication.
It retains an indication as an adjunct to warfarin for the prevention of postoperative thromboembolic complications of prosthetic cardiac valve replacement. While several biochemical effects of dipyridamole are known, the exact manner in which it causes platelet inhibition is unclear. When dipyridamle is used as an adjunct with warfarin, ASA should not be administered concomitantly. Miscellaneous - Other substances have been shown to be associated with acquired platelet dysfunction to the point of causing bleeding in some situations. Patrono C, et al.