Thin Auer rods are easily visible. All chromosomes appear normal. Generally, the appearance of additional chromosomal changes is associated with biologic progression of the leukemia. Immature cells from the marrow of a patient with M4 showing both granulocytic and monocytic features. In the schematic presentation of the translocation, the genes involved are DEK-CAN, as shown.
Hypergranular blasts predominate.
Cells contain bundles of delicate, needlelike Auer rods. It is generally associated with a favorable prognosis. The breakpoints on this partial karyotype are indicated by arrows.