This course provides an examination of toxicological effects of chemicals on the function of various organ systems. Normal physiology of the organ system is reviewed. This course provides a general introduction to the major areas of environmental toxicology and chemistry necessary to characterize human exposure, as well as procedures for using exposure and toxicity data to assess human health risks. Recent application of mechanistic concepts are reviewed. This course examines the mechanisms of toxicant-induced cell proliferation, differation, or death.
Emphasis is on metabolism, cell cycle regulation, mutagenesis, and initiation of cancer.
BB590, BB591, BB592, TOX511 recommended. This course examines the principles and methods of screening chemicals for their potential to cause genetic damage and, ultimately, cancer. Includes coverage of basic tests such as the Salmonella and micronucleus assays, plus newer approaches such as the 'comet' assay, CGH, FISH, and transgenic mutation assays.