Immunopathology of Chagas Disease Immunopathology of Chagas Disease Suppl. Inflammation subsides almost completely when immunity decreases parasite load and suppressor factors modulate host reaction, but inflammation does not disappear when the disease enters the indeterminate phase.
Inflammation becomes mild and focal and undergoes cyclic changes leading to complete resolution.
However, the process is maintained because the disappearance of old focal lesions is balanced by the upsurge of new ones. This equilibrium allows for prolonged host survival in the absence of symptoms or signs of disease. The mechanism responsible for the transition from the indeterminate to the cardiac form, is poorly understood. The major aspects of the pathogenesis of Chagas disease remain poorly understood. Some crucial pathological findings strongly suggest the participation of immunological fators.