Neurologic symptoms of lead encephalopathy include headache, confusion, stupor, coma, and seizures. Fundoscopic examination can show papilledema or optic neuritis. In the occupational setting, chronic exposure results in a slow, insidious, chronic intoxication with protean clinical manifestations. With further exposure, there is an increase in central nervous system symptoms such as insomnia, confusion, impaired concentration, and memory problems.
Lengthy exposure can present with a distal motor neuropathy with wrist drop.
Reproductive problems such as infertility in men and spontaneous abortion in women have been reported. Physical examination may demonstrate pallor due to anemia. Jaundice may be seen due to acute hemolysis.