Emphasis is placed on the common principles of absorption and relaxation techniques. 2dvanced x-ray diffraction methods. BMB 555 or equivalent, or permission of course director. Advanced topics in macromolecular x-ray diffraction. Synchrotron data collection, data processing, anomalous diffraction, phasing methods, density modification methods, refinement.
Emphasis is on applications and currently available methodology.
Macromolecular Modelling and Structure Analysis. Introduction to graphical analysis, modelling and simulation of macromolecules. Course will alternate lectures and hands-on computer modelling sessions. Enrollment is limited to twelve. Structural Basis of Protein-Nucleic Acid Recognition.