Vinpocetine is chemically related to, and derived from vincamine, an alkaloid found in the periwinkle plant. It was introduced into clinical practice in Europe more than two decades ago for the treatment of cerebrovascular disorders and related symptoms.
Levels peak in the bloodstream within an hour and a half after ingestion.
There have been quite a few studies with vinpocetine. There were no clinically relevant side effects reported. Statistically significant cognitive improvements were found in favor of active treatment groups compared to placebo. The patients on 10 mg performed slightly better than those on 20 mg. Forty-two patients received 10 mg vinpocetine three times a day for thirty days, then 5 mg three times a day for sixty days.