The proponents of the prion theory are rationalizers. They supposedly have every angle covered - establishing this, and establishing that. To nonscientists, they might appear to have everything nailed down. But it's all a bunch of muddle. The research skips from point to point failing to develop any point well enough to get at the truth.
Every test is portrayed as if it produced some objective fact.
But objective fact is extremely illusive with high tech science. The problem with high tech science is that the more complex and demanding the test is, the more difficult accounting for and measuring all of the factors which influence the result is. Therefore, numerous assumptions and guesses have to replace measured results. For example, if a mutation or altered gene is created through insertion, a test might indicate whether the mutation exists, with various degrees of certainty, but tests cannot determine how many other alterations occurred with it, because there are too many genes to test at too great of an expense. If a lot of time and money is focused on a subject, and a lot of low tech is included, then high tech can add something to science.