PDR irradiations were carried out with a nominal 37 GBq 192-Ir source. Eighty-six percent of the patients had no radiogenous skin changes in the boost area. However, GVO causes a number of substantial changes of the dose distribution which have consequences for its application. The interstitial CLDR boost of the breast can be replaced by the PDR technique without severe acute and late complications and without deterioration of the cosmetic results. The effectiveness of adjuvant postoperative radiotherapy after conservative surgery is debated.
Few data are available in Italy on the combined treatment.
One hundred and thirty nine women with DCIS of the breast were treated between 1980 and 1990. Median follow-up was 81 months. All recurrent patients had a salvage mastectomy and are alive and free of disease. The results of this retrospective multicentric study substantiate the favourable data reported in the literature and confirm the efficacy of the breast-conserving treatment of DCIS employing conservative surgery and adjuvant radiation therapy. To study clinical and pathological response rates of 5-FU and radiation.