Those close to you may chose to spend more time with you. As a result they will be missing out on a lot of social interaction too. They may do things without you, which can be lonely for them. Usually, the more intimate a relationship with an ill person is, the more likely the healthy person is to be isolated too. I have noticed that the healthy spouse was often as isolated, in many respects, as the ill partner.
Isolation can be a tremendous strain on any relationship.
The more creative ways that can be found to minimize the isolation, the happier everyone will be. On the other hand, there is something to be said for being forced to slow down, stand apart from the world, spend a lot more time with ourselves than we used to be able to handle, and look at ourselves and the world from a new perspective. This type of experience could conceivably be the breeding ground for wisdom. Also, this new perspective may incline us to rework our relationships so that they are much more satisfying. Grief is a big part of the journey through any illness.