Duchenne progresses slowly, yet eventually involves all voluntary muscles. Survival is rare beyond the 20's. Weakness and wasting of muscles of the hands, forearms and lower legs. Progresses slowly and rarely leads to total incapacity. Weakness and wasting of shoulder, upper arm and shin muscles.
Joint deformities are common.
Disease progresses slowly, yet sudden death can result from cardiac complications. Facial muscle weakness, with weakness and some wasting of the shoulders and upper arms. Progressing slowly with some periods of rapid deterioration, disease may span many decades. Weakness and wasting, affecting shoulder girdle and pelvic girdle first. Disease progresses slowly, with death most commonly occuring as a consequence of cardiopulmonary complications.