So make it a point to get out and network with others in your field. It might just give you the inside track on your dream job. Do your homework. Research the industry, the company, and even who you will be interviewing with. Mail resumes to who you want to work for even if they are not currently hiring.
History is replete with the person getting the job because of persistence.
Make sure you have the necessary skills. Look for what employers want. Then get what they want. Even if it means waiting a while before you apply. Work on your resume.