Occasionally, the reaction may be due to persons having become sensitised to the toxoid as a result of previous administration. In these cases, it has been shown that adequate boosting of the tetanus antibody titre will occur with a dose of 0.1 mL. An oral antihistamine may be given. Facilities should be at hand in the event of a severe allergic reaction occurring. The majority of the extensive delayed type local responses have occurred in adults following booster doses and in children who have received several doses of tetanus toxoid in the past. The increasing incidence of extensive local reactions is one reason a ten year interval between routine booster doses is recommended.
General reactions are uncommon after injection of tetanus toxoid.
Postvaccinal neurological disorders have been reported following the injection of almost all biological products, and the possibility of their occurrence must be considered. Interactions Therapeutic doses of chloramphenicol may interfere with the response to tetanus toxoid. Concomitant administration of this antibiotic should be avoided. The container should be thoroughly shaken before use to ensure adequate dispersion of the mineral carrier and the injection should be administered as soon as possible after the syringe is filled. To establish active immunity a full course of three injections of Tet-Tox must be given.