These cells are highly active in secretion of lysosomal enzymes and other contents into the extracellular space. Formed by fusion of macrophages. Fusion can be induced by monokines and may in part be due to attempted endocytosis of the same particle by several cells. These cells appear to have similar function as that of epithelioid cells. Lymphokines released by sensitized T-cells 3.
Granulomatous lesions are often difficult to distinguish from neoplasms in some tissues.
May vary with respect to central morphology. May be necrotic or suppurative in their center. May be other cells including epithelioid cells, giant cells, neutrophils, and plasma cells. If neutrophils are present in the center of granulomatous inflammatory reactions, they are often referred to a pyogranulomatous inflammatory reactions. Same as other chronic inflammatory reactions 5.