Detailed consideration of metabolic pathways and major sites of metabolic regulation. Catalytic properties, cofactors, and methods of regulation functioning in the pathways of intermediary metabolism are studied. Offered alternate years. 2 cr, 2nd sem. Advanced molecular biology using the current literature as a source of information.
Emphasis is placed on relevant research techniques.
Topics include structure and function of nucleic acids, recombinant DNA research, molecular biology of important cellular processes, and regulation of gene expression emphasizing control mechanisms in eukaryotic cells. Offered alternate years. 4 cr, 2nd sem. This course correlates the structure of proteins with their function. It considers the universality of certain regions, such as zinc fingers, calcium binding regions, DNA liganding sequences, in terms of their three dimensional structure, and considers the effect of site specific mutations in these regions on the function of the protein containing them.