There are human beings who are arranged in opposition to you and your service to God. But they are held in the sway of the devil when they do hurtful things to oppose you. They are trapped by someone who is destroying them and using them in destructive ways in the lives of other people. The appeal Paul is making is that we should want to see them converted. That's behind Jesus' statement as well.
Human beings are never our enemies ultimately, even when they do the most terrible things.
I don't want to gloss over the fact that you may have been treated terribly by someone. There are more than a million refugees in eastern Africa right now who are living in absolutely heart-wrenching conditions. And this has happened not because of some natural disaster such as a famine, but because of hatred between peoples in that part of the world. Real human beings have wreaked this destruction on other human beings. We can't minimize the capacity of humans to accomplish destruction and evil.