As such, meiosis stands at the gateway to sexual reproduction in most eukaryotic organisms. During meiosis, a complex, but tightly coordinated series of events occur.
Homologous chromosomes come together and pair along their entire length.
The 'hows' and 'whens' of these remarkable events have been under investigation for over 100 years. We also established in a yeast twohybrid assay that the N-terminal domain of SCP1 strongly interacted with itself. We investigated the fiber-forming properties of SCP3 both in vitro and in vivo. An in vitro binding assay and an in vivo coexpression study also supported this self-polymerising feature of SCP3. To test this model, we successfully generated SCP3-deficient mice.