Three groups of 44 participants each. Approximately 2 years. A negative pregnancy test within 60 days prior to study entry. Participants who received 2 or more PIs must have a total combined duration of continuous exposure for 2 or more years. Liver disease is no longer an exclusion.
First degree is defined as parents, brothers, sisters, or children.
Active drug or alcohol abuse or dependence which, in the opinion of the investigator, would interfere with adherence to study requirements. Participants should not be planning to initiate therapy with a PI in the upcoming months. Liver disease is no longer an exclusion. Chronic illness, defined as requiring systemic therapy, with the exception of hypertension. Investigator's decision that continuing in the study would be harmful to the health of the participant.