Thymidylate is essential for the synthesis of DNA so a deficiency inhibits cell division. Readily absorbed from the GI tract.
Food reduces the rate and extent of absorption.
Metabolites excreted in the urine. Those over 80 years may experience a greater incidence of GI side effects. Safety and efficacy in children less than 18 years of age have not been determined. Ataxia, encephalopathy, decreased level of consciousness, loss of consciousness, confusion. Anorexia, dehydration, cachexia, hypertriglyceridemia.