Lesions tend to recur unless the entire unit is destroyed or excised. Risk of permanent scarring must be considered when treating benign lesions. Isotretinoin in a daily dose as low as 10 mg per day is rarely indicated as a temporary suppressive treatment for widespread disfiguring sebaceous hyperplasia in a patient with no contraindications and prescribed by a physician expert in oral retinoid therapy. The goals of pharmacotherapy are to reduce morbidity and prevent complications. Retinoids - Isotretinoin has been used in sebaceous hyperplasia because of its ability to shrink sebaceous glands temporarily.
Lesions return after discontinuation of therapy.
Consider only for severe disfiguring cases in men or in women who cannot become pregnant. Should only be prescribed by dermatologists expert in oral retinoid therapy. Both agents are structurally related to vitamin A. Decreases sebaceous gland size and sebum production. May inhibit sebaceous gland differentiation and abnormal keratinization. Because of its action in reducing sebaceous gland size, it is used in sebaceous hyperplasia in lower doses than in acne.