There are enormous medical complications associated with cocaine use. Cocaine use has been linked to many types of heart disease. Physical symptoms may include chest pain, nausea, blurred vision, fever, muscle spasms, convulsions and coma. Different routes of cocaine administration can produce different adverse effects. Regularly snorting cocaine, for example, can lead to loss of sense of smell, nosebleeds, problems with swallowing, hoarseness, and an overall irritation of the nasal septum, which can lead to a chronically inflamed, runny nose.
Ingested cocaine can cause severe bowel gangrene, due to reduced blood flow.
Intravenous cocaine users may also experience an allergic reaction, either to the drug, or to some additive in street cocaine, which can result, in intake, many chronic cocaine users lose their appetites and can experience significant weight loss and malnourishment. Research has revealed a potentially dangerous interaction between cocaine and alcohol. Taken in combination, the two drugs are converted by the body to cocaethylene. Cocaethylene has a longer duration of action in the brain and is more toxic than either drug alone.