The microvascular system is so vast that what may seem like a large number of microspheres is still a trace concentration.
Estimates suggest that several grams of microspheres are needed to induce physiological effect.
An injection of 5 million microspheres has a mass of 10 mg. However, we strongly suggest the researchers use sansSaline TM rather than saline or PBS to reduce interference from activated sodium and chloride. However, we strongly suggest the researchers use sansSaline TM to remove interstitial blood rather than saline or PBS to reduce interference from activated sodium and chloride.