A disturbance in the maturation of differentiation of cells in growing hyaline cartilage. I. Long bones formed from cartilagenous models a.
Formation starts in center of the model and extends toward either end.
Cartilage cap is left at the bone ends. Second center of ossification begins in the cartilage caps and forms the epiphysis. Epiphysis and diaphysis remain separate to allow for long bone extension as animal matures. This is known as the physis. Separate physis develops adjacent to the articular cartilage.