It is not clear whether persistence of symptoms was due to age or length and severity of exposure. In one factory the highest incidence of symptoms occurred among those workers who worked in a room where hot freshly produced foam was processed. Further, some workers with the most severe symptoms had no skin contact with the foam. The highest levels of organic vapors in factory air samples were in the areas with a high incidence of affected workers. An underlying neuropathy probably also plays a role in the bladder dysfunction, and produces sensory loss, involving the sacral dermatomes and distal extremities, and some distal weakness.
Humans also show evidence of a loss of small and large axons.
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