Phenotype dictates the mitogenic response of vascular smooth muscle cells to changes in pulse pressure. Sustained pulsatile flow regulates endothelial nitric oxide synthase and cyclooxygenase expression in co-cultured vascular endothelial and smooth muscle cells. Ethanol enhances basal and flow-stimulated endothelial nitric oxide synthase activity in vitro by activating an inhibitory guanine nucleotide protein.
Ethanol inhibits basal and flow -induced vascular smooth muscle cell migration in vitro.
Enhanced Gi-protein mediated mitogenesis following chronic ethanol exposure in a rat hepatoma cell line. For questions or suggestions concerning the content of these pages, contact the URMC Webmaster .