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Goldenseal is native to eastern North America and is cultivated in Oregon and Washington.
It is seriously threatened by over-harvesting in the wild. The dried root and rhizome are used. Goldenseal was used by the Native Americans as a treatment for irritations and inflammation of the mucous membranes of the respiratory, digestive, and urinary tracts. It was commonly used topically for skin and eye infections. Because of its anti-microbial activity, goldenseal has a long history of use for infectious diarrhea , upper respiratory tract infections, and vaginal infections.