Treatment consists of application of a topical steroid and avoidance of the drug. It is thought to be an allergic reaction pattern of delayed hypersensitivity to both infectious and noninfectious agents. The eruption may be preceded by fatigue, arthralgia, weight loss, or malaise. Fever usually accompanies the eruption. The nodules may acquire a violaceous hue similar to that of a bruise.
Lesions usually resolve in three to six weeks.
A search should be made to determine the underlying cause of the drug eruption. Salicylates may be given for fever and joint discomfort. Elastic stockings, which provide firm support, may ease the pain. Rest and elevation of the legs are indicated. Morbilliform and urticarial skin eruptions were common manifestations of this syndrome.