Safe use of the drug in the treatment of juvenile rheumatoid arthritis has not been established. In a small percentage of patients, troublesome side effects may require temporary reduction of the initial dosage. The incidence of retinopathy has been reported to be higher when this maintenance dose is exceeded. Should a relapse occur after medication is withdrawn, therapy may be resumed or continued on an intermittent schedule if there are no ocular contraindications. Corticosteroids and salicylates may be used in conjunction with this compound, and they can generally be decreased gradually in dosage or eliminated after the drug has been used for several weeks.
Federal law prohibits dispensing without prescription.