The goal of Dr. Dewey's research is the development and study of genetic models affecting developmental, physiological, and behavioral processes. Useful genetic variation is identified through the traditional analyses of naturally occurring variant phenotypes or generated by the more direct approach of transgenic mouse production. Such a map will considerably enhance the usefulness of deer mice in a variety of research areas including speciation, behavior, and habitat variation. Determing the cellular site and mechanism of action of genes whose phenotypes simultaneously affect longevity and the kinetics of blood formation. The experimental approach to these questions involve the production of mosaic mice whose tissues are composed of genetically diverse populations of cells and which are produced by aggregating preimplantation embryos.
Genetic homozygosity is associated with increased telomere length in mammalian cells.
Yoo, S. D., J. W. Holladay, T. K. Fincher, H. Baumann, and M. J. Dewey. Bartell, J. G., T. Davis, E. J. Kremer, M. J. Dewey, W. S. Kistler. Expression of the rat testis-specific histone Hlt gene in transgenic mice. Holladay, J. W., M. J. Dewey, S. D. Yoo. 1996. Steady-state kinetics of in transgenic mice with elevated serum AAG levels.