Tests show that Rohypnol can be found in the urine for 72 hours after ingestion. Treatment Following overdose of a benzodiazepine, vomiting should not be induced because of the rapidity of onset of CNS depression. Gastric lavage should be undertaken within one hour of ingestion with the airway protected. Activated charcoal should be given to reduce absorption. Treat coma, hypotension and hypothermia if they occur.
Hypotension usually responds promptly to supine position and intravenous fluids.
It effectively antagonizes the CNS effects of benzodiazepines, including the depression of respiration. Its duration of action is 1-4 hours, and it can precipitate an abstinence syndrome in chronic users. Modern Pharmacology , 3rd ed. Little, Brown and Co, Boston 1986. Ro5-4200, February, 1994.