These infections often require hospitalization and can be fatal. Severe, malignant osteopetrosis is a life-threatening congenital disorder in which an overgrowth of bony structures leads to blindness, deafness and increased susceptibility to infection. In the most serious form of severe, malignant osteopetrosis, most patients become blind or anemic by six months of age and die within the first ten years of life, frequently in the first two years. Side effects may be minimized by bedtime administration and may decrease in severity as treatment continues. Acetaminophen may be used to prevent or partially alleviate the fever and headache.
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