C. Immunodeficiency disorders 1. In the cells of people with ADA deficiency, deoxyadenosine and adenosine are abundant because they are not degraded to deoxyinosine and inosine. They are, however, efficiently converted to nucleotides in white blood cells. The high levels of dATP inhibit ribonucleotide reductase, which inhibits DNA synthesis. Therefore, white blood cells cannot proliferate.
Gene therapy is an experimental treatment.