I need this information for toxicological studies. Your help is appreciated. We use a rat preparation with several indices of renal toxicity . 1. plasma clearances of iothalamate to approximate GFR and paraaminohippurate to approximate renal plasma flow 2. plasma and urinary electrolytes and osmolality 3. No one index is enough.
Gentamicin alone can trigger all three indices.
Hope that this helps provide a basis for your further consideration. Your help is greatly appreciated. This is an interesting question. It would appear, that there are a number of proposed methods for measuring the nephrotoxicity of antibiotics. These include NAG, renal proteins, creatinine, phospholipids and true antibiotic clearance.