Lewy bodies are intracytoplasmic, spherical, eosinophilic neuronal inclusion bodies.
Parkinsonism may occur spontaneously or part of an abnormal sensitivity to neuroleptic medications. Early on, there may be prominent deficits of tests of executive function and problem solving such as the Wisconsin Card sorting test or the Trail Making test. Later on, global impairment of mental function may blur the distinction between Alzheimer's disease where the major deficit lies in memory acquisition and consolidation. CT or MRI may show generalized cortical atrophy. Hashimoto M et al.