In clinical use, parenteral administration has occasionally produced mild, transitory fluctuations in blood pressure. These reactions have not presented a clinical problem and have not required supportive therapy. Following injection, some patients may become drowsy or unsteady. For these reasons, ambulatory patients should be kept under observation, preferably in bed, after treatment. Depression of the cardiovascular and respiratory centers may occur.
Management consists of supportive measures, close supervision and monitoring.
I.V. fluids should be administered if required and an adequate airway maintained. Cardiovascular and CNS stimulants may be used if necessary. Dialysis appears to be of limited value. As with the management of intentional overdosage with any drug, it should be borne in mind that multiple agents may have been ingested. Initiate therapy with 10 mg daily in divided doses, increasing if necessary to 30 mg daily in 2 to 3 divided doses.