Click here to view. 1.Different vasculitides are differentiated by pathologic and clinical findings and if known, etiological factors. V. Clinical vasculitides A. PAN 1. Necrotizing panarteritis of small to medium sized arteries. Inflammatory infiltrate contains PMN, lymphocytes and eosinophils, fibrinoid necrosis, disruption of elastic lamina.
Lesions are segmental and at different stages of development.
Lesions at arterial bifurcations, microaneurysms. Healed lesions - proliferation of fibrous tissue, endothelial cells, fibrosis. May occur at any age but peak age is 40-60 yrs. Systemic symptoms - fever, malaise, arthralgias, myalgias, wt loss. Similar clinical presentation to PAN except renal disease unusual.