People take refuge in material possessions, romantic relationships and sense pleasures, they believe these pleasures will give them true and lasting happiness and security. Some take refuge in their physical beauty, good health and strength. But that is still taking refuge in things which offer no real safety because these things are impermanent, temporary and uncertain. These things and conditions around us and in us can change at any time. We cannot guarantee what will happen in the future.
Life is uncertain, always changing, only death is certain.
Our bodies and physical looks have to change. We have to grow old, experience illness, and we all have to die someday. Our health and strength have to change, this is the law of nature. So there is no safety in the material and physical world. Our parents, spouses and children, and friends also have to grow old and die someday.