Estrogen may also influence the progress of pathological states in the uterus. A specific mRNA is estrogen-responsive in a tumor cell line. The course of expression of the corresponding protein is under study with the hope of finding a function for the protein.
Fibroids are benign tumors of the uterus which frequently cause extensive bleeding.
The role of estrogen in the growth of fibroids and in the maintenance of the integrity of the arterioles and capillaries is under study. The regulation of uterine tissue factor by estrogen. Cellular localization of tissue factor and prothrombin in the estrogen-treated immature rat uterus. Biol. of Reprod.