Delete that registry line. This latter move prevents re-infection from the current version of the Trojan, since it looks for NOTE.COM and won't infect a system that has it. Of course this is no guarantee that a new version that knows this trick won't come out next week. That's the short-term prevention. The long term is harder.
Firewalls are essential.
Microsoft's experience shows even the largest and most knowledgeable companies can be vulnerable, but Microsoft has many employees who work away from campus and require full access. If you have no such requirement you can make security a lot tighter, but you are still vulnerable to e-mail attachments. I pay a fair amount of attention to security matters, and we managed to get the QAZ Trojan inside my firewall. Think about that. This was the big attraction of Java over Active-X and other such tools.