The cellular molecules responsible for improving efficiency in the cell have been identified and are termed chaperones. We have used the E. coli chaperones GroEL and GroES to investigate the molecular mechanisms of this intriguing family of proteins, but are now extending this work to include the Archaebacterial chaperonins. This latter class closely resembles those found in the eukaryotic cell and we wish to compare the mechanistic properties with the more intensely studied prokaryotic counterparts. This is for quicker loading. Where full texts are available through PubMed, a direct link to the PDF file is provided.
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Users within the University of Bristol should be able to access all the articles below. Detection and characterization of intermediates in the folding of large proteins by the use of genetically inserted tryptophan probes. Binding of a chaperonin to the folding intermediates of lactate dehydrogenase. Biochemistry PubMed reference - Medline reference 3. The influence of chaperonins on protein folding.