Any change in a pigmented lesion should be biopsied. For a solitary lesion simple excision is curative. Clinical experience with pigmented lesions is necessary for the proper diagnosis to be obtained. Persons with unusual nevi or many nevi may benefit from consultation with a dermatologist. Common blue nevi are clinically benign.
Lesions tend to persist unchanged throughout life.
Cellular blue nevi are usually clinically benign. Due to their larger size they tend to be biopsied and excised more often than common blue nevi. Rare cases of malignant melanoma have been reported to arise in cellular blue nevi. Any change in these lesions is an indication for biopsy or excision. The prognosis of blue nevi is excellent.