A wide variety of vertebrates eat Spadefoot Toads. During the spring and summer according to the availability of water sources. This occurs mostly in June and July, and then they are highly explosive with breeding periods only lasting a few days. The males arrive at the pools first to begin calling. Then the females arrive and seek out the right male.
Males often engage in active searching and competition for individual females.
The call of a Eastern Spadefoot Toad to attract a female is a low-pitched, short, grunting note repeated at brief intervals. Eastern Spadefoot Toads lay their eggs in irregular strings along grass stems in the water. Each female lays up to 2,500 eggs. The eggs hatch in 2-4 days. The tadpoles of this species are small, bronze-colored tadpoles with short rounded tails that have tiny spots on them.