Phase II metabolism adds or exposes a functional group to increase water solubility. Grapefruit juice is an inhibitor of cytochrome P450. Chronic alcohol use is a cytochrome P450 inducer. It could be bad to give H2O after overdose because it might solubilize the drug.
Inclusion bodies release toxicants into the cell.
Oxidation is a proces of phase 2 metabolism. Alcohol can be both an inducer and an inhibitor of cytochrome P450. The brain has high drug metabolism which makes it susceptible to lipid peroxidation. In addition to protecting the heart, estrogens also help in healing. A decrease in lipid diet causes a decrease in lipid peroxidation causing an increase in drug metabolism.