From its headwaters in the North Fork of the John Day Wilderness Area to its confluence with Camas Creek. From its headwaters to Camas Creek, the North Fork of the John Day River is one of the most important rivers in northeast Oregon for the production of anadromous fish. Wildlife found along the river's corridor include mule deer, elk, and black bears, along with peregrine falcons and bald eagles. Its diverse landscape and geologic formations create high quality natural scenery.
Manmade developments have a primitive or historic appearance, including early day mining remains.
There is a great deal of history from the gold mining era tied to this area, which began in the 1860's. Recreation opportunities include hunting, fishing, sightseeing, horseback riding, hiking, snowmobiling, skiing, camping, and whitewater rafting.