It is possible to map where cities are, and there is a sense of locality. Note that gravity is attractive, but itzu jumping from one city to another is repulsive. Cities will not usually be cold, metallic, and gray. They may resemble red coral reefs, or green lattice structures like huge diamond crystals, or soft black tangles of plants, or blue bags of water. Itzu will be backed up, just as hard drives are backed up today.
Insurance is a first profession.
Insurance companies will be in the business of collecting backups, maintaining the backups as reliably and efficiently as possible, and recreating itzu from the latest backup when something happens to them. That means that itzu are immortal. Well, no, there's a lot more space than matter. Itzu can't count on death, but if they live in a community they can count on taxes. And taxes mean matter taxes, including the matter they are composed of.