Tumor Cells is not reduced by the protective effect of iron chelator, hydroxyl radical scavenger and Cytochrome P-450 inhibitors against cisplatin induced nephrotoxicity . Tumor Cells is not reduced by the protective effect of iron chelator, hydroxyl radical scavenger and Cytochrome P-450 inhibitors against cisplatin induced nephrotoxicity .
Iron plays an important role in cisplatin induced free radical medicated tissue injury.
Researchers have demonstrated that iron chelators, hydroxyl radical scavengers and CYP inhibitors show marked protection against cisplatin induced nephrotoxicity. Additionally, it has been shown that these agents do not affect the tumorical effect of CP while being protective to the kidney. These agents will significantly reduce the nephrotoxicity and allow the full benefit of CP on tumor cells. Kidney International, Vol. Kidney International, Vol.