Brain requires direct use of glucose for energy. See fig 1 hepatic steatosis as a result of fatty mobilization. Arginin increases it the most.
Histidine increases it the least.
Brain edema-flattening of gyri Summary Diabetes is mainly a metabolic disease of improper handling by the cell of metabolic fuels. See example of pyelonephritis in a diabetic patient Fig 2 weight loss Ketosis Large and small vessel disease. 5 Vascular disease Fig 6 Shows atheroma plaque in vessel from diabetic patient. Renal damage from diabetes can result in Kimmelstiel Wilson Disease fig.