It has been described as a genetic defect in many breeds, and intrauterine fetal infections with BVD and bluetongue viruses have also been incriminated as causative agents. Mannosidosis Mannosidosis is a lyosomal storage disease associated with accumulation and storage of the enzyme a-mannosidase. The deficiency of a-mannosidase is characterized by ataxia, incoordination, head tremor, aggression, and reduced growth. Calves may be affected at birth, but clinical signs usually do not appear until they are several weeks or months of age. The most affected cattle die within the first 12 months of life.
Heterozygous animals are carriers.
This is a simple autosomal recessive condition and can be defined biochemically. It has been reported in Angus and Murray Grey cattle. Skin Defects Congenital hypotrichosis The most common skin defect is congenital hypotrichosis, which is the complete or partial congenital absence of hair. Six forms have been described, varying from complete hairlessness to semi- hairlessness. The semi-hairless types generally occur in Polled Herefords.