When neurons in the basal ganglia are activated, as occurs with limb movement, the blood flow increases. Comparisons are possible of the degree of alteration from baseline assessment of neuronal activity in this region. These changes can be compared between normal individuals and HIV-infected persons with dementia and associated movement abnormalities. The effects of various therapeutic strategies that enhance dopaminergic activity will be assessed in the HIV study population to determine whether these agents have any potential in ameliorating the illness. Intratumoral Chemotherapy at the University of Kentucky by Roy A. Patchell, M.D .
Malignant gliomas are the most common brain tumors in adults.
Unfortunately, the results with all present methods of treatment for these tumors have been poor. Even with aggressive treatment consisting of surgery, radiation therapy, and intavenous chemotherapy, less than half of patients live more than one year. Surgery and radiation therapy have probably reached maximal effectiveness. Chemotherapy still has the potential to improve survival but has had only limited success for several reasons. Also, even when the drug does get into the brain, it remains active in the body for only a few hours and does not have enought time to destroy the tumor.