In addition, we have obtained the plasmid containing the MID1 gene from yeast which codes for the only SACC gene product cloned to date. With these studies we hope to characterize the events which initiate and propagate increased vascular permeability secondary to mechanical stress and identify potential targets for pharmacological intervention in patients. We are currently applying for Phase II funding and will finalize prototype designs for production. Controller algorithms are being developed for optimal control of tidal wave forms and automatic control of residual liquid volumes in the lung for efficient long term ventilation with minimal peak alveolar pressures. Parker, J.C., C. Ivey and J. Allan Tucker.
Gadolinium prevents high airway pressure induced permeability increases in isolated rat lungs.
Parker, J.C., C. L. Ivey and J.A. Tucker. Phosphotyrosine phosphatase inhibition increases airway pressure induced lung injury. M.I. Townsley, and T. Stevens. Parker, J.C., and A. E. Taylor. C.E.G. Lundgren and J.N. Miller.