Toxicology screens are primarily useful in ruling out other toxins. Obtain pregnancy tests in women of childbearing age. Antipyretics and use of a cooling blanket are generally inadequate. The best methods for cooling patients include increasing evaporative losses by wetting their skin with warm water and maintaining airflow over them with fans. Removing the patient's clothing and exposing the patient to room air may help.
Fluid therapy is of paramount importance.
Patients may be significantly dehydrated from hyperthermia. Treating the associated hypertension is usually not necessary. If antihypertensive therapy is deemed necessary, use of a short acting antihypertensive agent, such as nitroprusside, is advisable. Critical care management may be required for cardiovascular complications. Network of pores present in activated charcoal adsorbs 100-1000 mg of drug per gram of charcoal.