It was first registered for use in 1974. Roundup is one of the most widely used pesticides by volume. Because glyphosate is so widely used, it has been extensively studied by the makers and independent researchers. Toxicology Branch Ad Hoc Committee. Binding to soil particles is also responsible for inhibiting soil microorganisms.
Fungal species are important to the cycling of nutrients.
In 1995, glyphosate ranked eighth. Aspelin, A.L. 1994. Re-registration Eligibility Decision, Glyphosate. Sawada, Y., Y. Nagai, and I. Yamamoto. Probable toxicity of surface-active agent in commercial herbicide containing glyphosate.