Other symptoms of uremia include nausea, vomiting, weight loss, metallic taste in the mouth and odor on the breath, itching, a frosty look to the skin, muscle pain and twitching, increased blood pressure, swelling and water retention, and mental confusion. The disorder is confirmed by physical and laboratory diagnosis of kidney failure. Treatment focuses on correcting the kidney condition or improving platelet function. Kidney disease may be addressed with dialysis or successful kidney transplant. Most patients with kidney failure are anemic.
Hepatocellular disease is disease of the liver.
Examples include cancers such as hepatocellular carcinomas and adenomas. Advanced liver disease often results in platelet dysfunction and bleeding. Platelet levels are often decreased in liver disease because an enlarged spleen traps platelets so they cannot reenter the bloodstream. In patients with a history of alcohol abuse, low platelet levels may be caused by the toxic effects of alcohol on platelet production in the bone marrow. Please see Liver Cancer .