Usually develops in cirrhotic liver especially often in cirrhosis caused by hepatitis B and C, AAT deficiency and hemochromatosis. Oliguric renal failure secondary to the hormonal and circulatory changes that accompany cirrhosis . The kidney shows no pathologic changes. Oncotic edema is the most prominent consequence of hypoalbuminemia. Associated with brain damage.
Etiology is unknown.
Histologically, presents in the form of giant cell hepatitis. An autoimmune disease characterized by destruction of intrahepatic bile ducts and obstructive jaundice. Typically affects middle aged women. Antimitochondrial antibodies are present in the serum of almost all patients. Disease progresses to cirrhosis .