Hospital admission is recommended for severe cases.
Treatment consists of three drugs that are effective against the organism. Sputum should be negative after 3 months of therapy. If not, treatment is reevaluated. If a patient is unable to tolerate isoniazid, or if isoniazid-resistant TB is present, rifampin, ethambutol, and pyrazidamide are usually used for 18 months. If rifampin-resistant TB is present, the regimen usually consists of isonizaid, ethambutol, and pyrazidamide for 18 months.