Design an experiment using the recombinant vaccinia virus constructs to confirm cytotoxic killing of target cells expressing the viral peptides. Surprisingly, the natives in the jungle are resistant to Zaire virus being eliminated by the immune response in a few days. For cytotoxic T cell response, effector T cells interact withtarget cells via MHC class I molecules. Diagram the interactions between the T cell receptor and various accessory molecules with their ligands on the target cell. In immune response against Zaire virus, many cytokines would be secreted by different cells.
Controls are non transgenic A.TL macrophages.
Shown is a photo of Mycobgacteria leprae in macrophages.