The portico features six Tuscan columns and a large, elaborate caduceus, the symbol of the medical profession. A centrally located cupola with Roman windows sits atop the standing-seam, hipped copper roof. Other symmetrical features include rounded-arched windows, and pilasters found on all corners of the building. On the north end of the structure is a recessed doorway with columns in antis . From the front portico, a vestibule leads into the domed rotunda which is central to the organization of the building.
Corridors lead to the flanking pavilions which have been adapted as meeting rooms.
The basement contains offices used by the Medical Association of Atlanta. The Academy of Medicine combines exceptionally high artistic values, quality craftsmanship, and integrity. The Neo-Classical style is recognized as important to twentieth century architecture in the United States. Architect Philip T. Shutze has been acknowledged by scholars of architectural design as a regional master of the Neo-Classical and someone worthy of national recognition. Atlanta is fortunate to have the Academy of Medicine as an intact example of the work of this architect.