For example, audio clips should be accompanied by a transcript for the deaf user. Video clips should not be essential to the information presented on the site. If they are, you may want to consider including a hyperlink to an information page which will convey the information in a textual manner. Animated presentations should have an explanatory ALT description for the visually impaired. Don't make this description too long, however, some speech synthesizers have size limits.
Frames are difficult for a speech synthesizer to interpret.
If you must design your site in frames, label the top frame clearly with alternate navigational methods. To assist motion impaired users, navigation options should be clearly labeled and easy to click on. Use descriptive text instead. This is an unnecessary bit of extra clicks even for people without motion impairments. If you use tables for your layout, keep all the information pertaining to a topic in one cell.