Inflammation and scarring cause the ducts to narrow, and bile accumulates in the liver. Many times, patients also have inflammatory bowel disease. More common in men than in women, PSC carries symptoms of itching, jaundice, fatigue, and bouts of fever. Sometimes blocked bile ducts can be opened through surgery or other procedures, improving the bile flow. When the ducts remain affected, after several years liver failure may occur.
Liver transplantation is the only apparent cure.
Autoimmune hepatitis with cirrhosis . In this disease, the body s immune system attacks the liver. The symptoms are similar to those of acute hepatitis namely, jaundice, fever, and liver dysfunction but a liver biopsy and specific laboratory testing for autoantibodies can distinguish between the two. The condition causes inflammation and kills liver cells. Steroidal treatment and azathioprine, a drug used to combat inflammatory diseases, often prove beneficial to patients with autoimmune hepatitis.