Surfactant-related studies involve both basic and clinical research. A variety of laboratory techniques are used to examine the activity of endogenous lung surfactant and synthetic exogenous substitutes, how these surfactants can be inactivated by various inhibitors, and how inactivation can be overcome. A focus of recent research involves combining exogenous surfactants with other agents in combined modality therapies for ARDS-related acute lung injury.
Acid aspiration increases sensitivity to increased ambient oxygen concentrations.
Surfactant therapy and its potential use with other agents in term neonates, children, and adults with acute lung injury. Uy IP, Pryhuber GS, Chess PR, Notter RH . Combined-modality therapy with inhaled nitric oxide and exogenous surfactant in term infants with acute respiratory failure. Notter RH . For questions or suggestions concerning the content of these pages, contact the URMC Webmaster .