Thymoma with pemphigus foliaceus. Cytogenetic profile of a thymoma. A case report and review of the literature. Surgery is the first therapeutic option, but in advanced disease a multidisciplinary approach is feasible, because of chemosensitivity and radiosensitivity of the disease. The natural history of thymoma after surgery points to local recurrence.
Adjuvant radiotherapy seems to improve local control and survival.
Chemotherapy based on cisplatin plus anthracyclines could be performed in advanced and metastatic disease. The optimal sequence of chemotherapy, radiation therapy and surgery is yet to be defined. In our experience, primary chemotherapy seems to give best results in advanced thymoma with good tolerability. She had been feeling well except for general fatigue. Physical examination revealed a mass in the jugular region, a little over 2 cm in diameter.