It's a little awesome to have the responsibility of saying that SAM-e is really good. Moreover, part of its appeal is the possibility that it may have wide applications. This link to Alzheimer's is far from established. And if that wasn't enough, SAM-e is said to be a fast acting treatment for depression, sometimes easing symptoms in one to two weeks. It also has few side effects and does not appear to interact with other medications.
Doctors say nothing can do so much.
Discovered in 1952, there is an extensive body of scientific study on SAM-e, and very few researchers dismiss its therapeutic potential. But there are several reasons why doctors may be wary of advising patients to try SAM-e. For one, most studies on SAM-e are from Europe, where it is an approved and popular treatment in several countries for various disorders, such as depression and arthritis. And there are few of the large, long-term, randomized clinical trials that U.S doctors favor. Others say the substance is of value, but little is known about dosage, long-term effects and how it compares with other medications.