Fluorescein angiographic findings Usually early hyperfluorescence of the streaks with late staining. Histology Angioid streaks are visible defects in the thickened, calcified elastic layer of Bruch's membrane. Traction of extraocular muscles around fixed origin. An autosomal recessive disease characterized by systemic elastic fiber abnormalities with secondary calcification. Affects the skin, eyes, GI tract and heart.
Diagnosis is made by skin biopsy.
Higher incidence of optic disc drusen 2. Dx made by elevated serum alkaline phosphatase and urine calcium. Varying reports but angioid streaks are found in approx. Patients have hyperextendable skin and loose joints. Usually asymptomatic but visual loss from associated complications occurs with time.