The VC508 has no built-in reverb, and you'll need either a reverb or an analog delay to get that blues sound. There are plenty of stompbox analog delays by vendors like DoD, Ibanez, Boss, etc. The Shure mics are used by many pros, including Rob Paparozzi and Clint Hoover . That's all the gear you need to get a good Chicago sound. This setup is inexpensive, versatile, and high quality, and it scales up and down to fit almost any performing or practice situation.
Good sound is mostly the result of good breathing technique and a relaxed posture from the waist up.