To ascertain efficacy, regular PSA and other serum and imagery testing is suggested. The Foundation has developed an integrated approach that involves the concomitant use of FDA-approved drugs combined with natural supplements. A brief description of these natural therapies follows, with a more extensive dissertation printed in the Prostate Cancer Adjuvant Therapy Protocol. Prostate cancer patients usually take five 700 mg capsules of Mega Soy Extract 3 to 4 times a day. Mega Soy Extract provides pharmaceutical doses of soy isoflavones such as genistein.
Cancer cells use the enzyme protein kinase as a growth factor.
Soy genistein is a potent inhibitor of protein kinase activity. The effects of protein kinase inhibitors on human prostate cell growth have been extensively investigated. These phytochemicals protect against cancer via several different mechanisms, including interacting with intracellular enzymes, regulating protein synthesis, controlling growth-factor action, inhibiting malignant cell proliferation, inducing differentiation, deterring cancer cell adhesion, and inhibiting angiogenesis. Animal experiments provide evidence suggesting that both lignins and isoflavonoids in soy may prevent the development of cancer. Genistein may prevent the expression of metastasic capacity in hormone-dependent cancers.