Thus any quantitative model for the UV induction of melanoma will have significantly more uncertainty than that for SCC and probably more than that for BCC as well. There are also a number of issues that need to be addressed with regard to the assumptions chosen for the dose-response models used to approximate the relationship between exposure and effect. UV is important. Given below in Fig. Calculations for skin cancer risks are performed for five scenarios applying the UV-chain methodology developed by Slaper et al. 1996, and assuming full worldwide compliance with the agreed protocols within the Vienna Convention.
Excess cases refer to additional cases due to ozone depletion.
Although it is now adequately documented that UV radiation can modulate immune reactions in rodents as well as in humans, the impact of current levels of ambient solar UV radiation on infections in human populations is still unknown. Consequently, we are still completely ignorant when it comes to quantifying possible effects on infections of ozone depletion. In developing animal models for the effects of UV radiation on infections, investigators have been measuring changes in fundamental immune reactions that are associated with the course of the infection and that may also be measured in humans. This approach is in its infancy and requires a thorough and detailed knowledge of the immunological responses that play a role in any particular infection under consideration, in order to identify the relevant measurements. This approach also has certain limitations in that the outcome of such analysis only evaluates host resistance and does not provide complete information on the spread and course of an infection in a population.