Chemotherapy also may be used in late stages of cancer to reduce the size of a tumor. The method described by Dr. Wallace Clark for measuring the penetration of a primary melanoma into the skin by anatomic layer. I refers to melanomas confined to the outermost layer of the skin called the epidermis. Levels II-IV refers to different degrees of penetration into the second layer of the skin called the dermis. Clinical trial investigational studies of new treatments, new uses of existing treatment, or new screening methods to detect disease.
Cytokines are in use as anti-cancer drugs.
Dysplastic alteration in size, shape and organization of cells. Informed consent the process by which a volunteer for a clinical trial agrees to participate after being fully informed regarding purposes of the trial, risks and benefits associated with participation in the trial, and whether volunteers will be randomized to receive treatment or placebo. Interferons A family of disease-fighting molecules produced naturally in the body, but also made in the laboratory as drugs to enhance the body's ability to destroy viruses and cancer cells. Interferon is sometimes used in combination with chemotherapy. Level See Clark Level of Invasion Malignant when referring to cancer, malignant means the ability to grow and spread in an uncontrolled manner beyond the local confines of the tumor.