Dear Jennie, I apologize for the delay, however melatonin is quite young in terms of it's therapuetic uses in current medicine, hence the facts are limited. The change should be interpreted by your physician because you may need to take more or less or even continue with the same dose of daily warfarin, in the case of anticoagulation for an artificial valve, always, always get your PT rechecked at the start of ANY new medication as too low a PT may run the risk of clotting the valve, a potentially disatrous consequence. You might also know that melatonin is being investigated as a treatment in many other forms, for example it is believed to act like an oral contraceptive in chronic dosing, but as it has not been fully studied or investigated in trials it is not known in what persons, in which doses, or in what manner it qualifies as birth control.
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