Several participants commented that they liked the fact that the drug is excreted unmetabolized, and that it works well with other drugs the person may be currently taking. Gabapentin is an oral antiepileptic agent. The mechanism of action is unknown. However, its pharmacodynamic mechanism is different from other substances that interact with GABA synapses. Its' binding occurs in the outer layers of the neocortex and the hippocampus, but the receptor and its biochemical function remain undiscovered.
Elimination is unaltered by dose or following multiple dosing.
Elimination rate is constant. Dosage adjustments are necessary in those patients with compromised renal function. Hypersensitivity to gabapentin. If you are pregnant or thinking about becoming pregnant, be sure and talk to your physician about this. Also, it is not known if the drug crosses into breast milk.