It has a dramatic onset, with dyspnea, tachypnea, bilateral pulmonary infiltrates and low Po2 levels. Treatment requires supportive measures only. Intubation is rarely required. The clinical course is short-lived, with gradual improvement after 48 hours and complete resolution in 72 hours. There are no long-term sequelae.
Differential diagnosis includes pulmonary embolization, fluid overload and aspiration.
The clinical course was typical of this condition, with spontaneous clearing in 72 hours with supportive measures only. Trophoblastic pulmonary embolization can occur following abdominal hysterectomy for invasive mole as well as after molar evacuation and should be considered part of the differential diagnosis if patients present postoperatively with acute respiratory distress. Apoptosis has been found to play a crucial role in the pathogenesis and prognosis of many human diseases. Prognostic indicators of HM have also been scanty. Extensive apoptosis was located in syncytiotrophoblasts, cytotrophoblasts, and villous stromal cells in all HM cases.