Federal law prohibits dispensing without prescription.
Many Migraineurs have experienced this safe treatment at an emergency room visit. This is a very safe and effective treatment for the non-pain symptoms of nausea and vomiting associated with Migraines. It is an H1-antagonist with considerable anticholinergic, sedative, and antiemetic effects and some local anesthetic properties. Promethazine is a versatile drug but is used predominantly as an antiemetic or to prevent motion sickness. Promethazine was approved by the FDA in 1951.