To predict the efficacy of the treatment, one must run dosimetic calculations. This implies an a priori knowledge of the drug concentration. This requires an understanding of the magnetic properties of the agents under physiological conditions. We are characterizing a gadolinium labeled carbon derivative for dual MRI and NCt applications. Radioactive isotopes of technetium, yttrium, indium, and samarium offer applications in radioscintography and radiotherapy.
Gadolinium has applications in magnetic resonance imaging and neutron capture therapy.
Folic acid was attached to these polymers. They specifically bind to tumor cells that express the high affinity folate receptor. We are using these polymers to diagnose and treat tumors that express this receptor in vivo. Tumors of epithelial origin express this receptor.