Always wash well before anal play. Anal play is safer if you wash the anus and surrounding area with soap and water beforehand. Always wash towels and bedsheets. Imagine the pain of damaging your penis during unusually athletic sex. Also imagine the tearing to the lining of the vagina or anus if you're not careful.
Athletic sex refers to extremely vigorous sex involving penetration of some kind.
When a penis is involved, there is the danger of causing trauma to the penis especially if the other partner is on top. If the penis misses entry during copulation, it can jam against the body of the partner, possibly causing some of the vessels in the penis to burst, or tissue to tear. If this does happen, go immediately to an emergency room. In the case of tearing and abrasion, always use copious amounts of lubrication to lessen the amount of friction against the tissue. It's no mystery that sex is a strenuous activity.