The data was then statistically analyzed by chi square testing. Inst. of antibiotic cycling has led to decreased resistance in Pseudomonas aeruginosa and Klebsiella pneumoniae . None of the other bacteria isolated showed any increase in resistance during antibiotic cycling. They all had either no change or a decline in resistance which was statistically insignificant. Antibiotic cycling in the ICU appears to decrease or at least stabilize the emergence of resistant bacteria, especially P. aeruginosa and K. pneumoniae .
Further study is needed to address the best cycling intervals and antibiotic selection.