Although chemically the only difference between testosterone and 1-testosterone is the position of the double bond, pharmacologically the two products are quite different. That makes 1-testosterone a phenomenally potent compound, surpassing even most synthetic anabolic steroids. No Aromatization 1-testosterone differs from testosterone in another way as well. This makes 1-AD unique compared to other prohormones all of which can either aromatize directly, convert to a product that aromatizes, or both. The Only Truly Orally Active Prohormone Natural androgenic steroids are normally not very active orally.
Large amounts have to be taken orally to see biological effects.
However, this alkyl derivatization also greatly increases the liver toxicity. Luckily, there are other ways to render a steroid orally active, and do so without making the compound toxic to the liver. Certain structural modifications can alter the metabolism of steroids making them resistant to liver breakdown. One steroid that has this structural modification and is orally active is the anabolic steroid Methenolone, also known as Primobolan. As you may have noticed, this double bond position that makes Primobolan orally active is the same one found in 1-AD, which, by the way, is also orally active.