We are using various genetic and cell biological approaches to elucidate the underlying cause of the observed tissue-specific resistances in both hosts. Finally, the hallmark of baculovirus-induced pathology is liquefaction of the host. This dramatic ending is coincident with death and is mediated by two virus-encoded enzymes, a cathepsin and a chitinase. We are interested in illuminating the interaction and regulation of these two enzymes. The central role of hemocytes in Autographa californica M nucleopolyhedrovirus pathogenesis in Heliothis virescens and Helicoverpa zea.
Filamentous actin is required for lepidopteran nucleopolyhedrovirus progeny production.
J. Gen. Virol . Direct proof that nuclear F-actin is essential for AcMNPV morphogenesis. Virus Res . A conduit for the systemic spread of Autographa californica nuclear polyhedrosis virus.