28 Administration of bromelain pre-surgically can reduce the average number of days for complete disappearance of pain and inflammation. A drastic reduction in the incidence of coronary infarct after administration of potassium and magnesium orotate along with 120-400 mg of bromelain per day has been reported. The allergenic potential of proteolytic enzymes should not be underestimated. 37 Bromelain, due to its use as a meat tenderizer and to clarify beer, is considered a potential ingestive allergen. Most research on bromelain has been done utilizing four divided daily doses.
Findings indicate that results are dose-dependent.
White RR, Crawley FE, Vellini M, et al. Bioavailability of 125I bromelain after oral administration to rats. Kumakura S, Yamashita M, Tsurufuji S. Effect of bromelain on kaolin-induced inflammation in rats. Uchida Y, Katori M. Independent consumption of high and low molecular weight kininogens in vivo. Fibrinolytic and antithrombotic action of bromelain may eliminate thrombosis in heart patients.