Ferrets also require Imrab-3 for rabies. Ferrets are unlikely to come into contact with rabies, and even if they do, have only slim chance of shedding it in their saliva. There has never been a case in the history of the United States of ferret passing rabies onto a human. However, if your ferret is not vaccinated, and he bites or nips someone, he can and will be killed and tested. A vaccinated ferret will most likely just be quarantined for several days or weeks.
Ferrets occasionally have reactions to vaccinations.
These are rare, but can be life threatening. Just because your ferret has never had a reaction does not mean he will never have one. It is a good idea to stay at the vets office for 20-30 minutes after a vaccination to be on the safe side. It is also a good idea to separate your ferrets canine distemper shot and your ferrets rabies shot by three weeks. If your ferret exhibits any kind of strange behavior after a reaction, such as vomiting, diarrhea, lethargy, or anything out of the ordinary, get the ferret back to the vet immediately.