There have been some cases where as little as two to three weeks of use have been documented to severely reduce the ability of the liver to detoxify naturally produced estrogen. Candida yeast ferments dietary sugars into liver-toxic acetaldehyde in the process of turning sugar into energy. Candida also appears to increase gut and urinary levels of ammonia, another liver toxin. Pesticides such as PDT, Aldrin, chlordane, lindane, 2,4,5-T dioxin, and toxaphene can cause chronic liver damage even at levels measured in parts per billion because they tend to accumulate in body fat over a lifetime. Potential liver damage is a common warning found in prescription drug descriptions.
Liver damage is a major side effect of chronic steroid abuse by athletes.
People should be careful not to take too many drugs containing acetaminophen at the same time. Taking more than 15 grams can lead to irreversible liver disease. People who consume large amounts of alcohol are at highest risk of developing liver damage from overuse of acetaminophen. Acetaminophen was originally introduced in 1955 for children's fever and pain relief. It's not uncommon for infant formulas to contain higher amounts of active ingredients than children's formulas.