However, it's everywhere only in very small quantities. In young people the liver is able to synthesize CoQ10 from other coenzymes, but that ability gradually declines with age. Liver disease, excessive use of alcohol and acetaminophen can also affect the liver s ability to synthesize CoQ10. The body then becomes more susceptible to heart disease and a variety of other ailments unless the diet is supplemented. Bioavailability is another factor.
Enhanced absorption allows blood levels to normalize and beneficial effects to be seen more quickly.
In heart patients, the severity of CoQ10 deficiency correlates with increasing symptoms. Many researchers have now realized that the most effective therapeutic dosage for CoQ10 would then be the amount needed to return blood and tissue levels to normal as quickly as possible. A clinical trial published in 1994 clearly shows a dose dependent relationship in the effects of CoQ10 treatment for women with high-risk breast cancer. When the dose was increased to 390 mg. Another recent study completed by researchers at the University of Texas study confirmed the success of CoQ10 therapy for 424 patients with various forms of cardiovascular disease.