The objective is to identify biochemical mechanism of anesthetic hepatic and renal contributions to anesthetic metabolism, identify drug interactions and pathophysiology predisposing to anesthetic toxicity, and selectively manipulate P450 isozymes to prevent anesthetic toxicity in patients. Mechanisms of interindividual differences in opioid anesthetic disposition. The objective is to identify the biochemical mechanisms responsible for interindividual variability in opioid pharmacokinetics. We aim to identify human P450 isozymes responsible for opioid metabolism, the population distribution, drug interactions, and pathophysiologic factors affecting P450 isoform expression and anesthetic disposition. Stereochemistry and anesthetic disposition.
Many anesthetics exist as racemates, or pairs of optically active enantiomers.
These enantiomers may have significantly different anesthetic effects and rates of biotransformation. Endogenous alkaloid opiates in humans. Our objective is to characterize this system in humans. Drug Metab Dispos. Contribution of CYP2E1 and CYP3A to acetaminophen reactive metabolite formation.