This will be mostly achieved by patch clamp recordings from slices which are treated with agents that activate or block specific signalling steps, with parallel assays experiments to verify those changes in signalling pathways. Long term goal of this lab will likely be concentrating on the central dopamine system, using either parabrachial slice or other brain regions as a model system, to better understand how dopamine modulate synaptic strength, what drives the central dopamine system, and interaction between the dopamine and the opioid system. Previous work on neuropeptides in the brain may also be extended in the future. J. Neurophysiol . Vasopressin and amastatin induce V 1 receptor-mediated depression of excitatory transmission in the rat parabrachial nucleus.
Dopamine depresses glutamatergic transmission in the rat parabrachial nucleus in vitro.
Reduced sympathetic activation but not enhanced vasopressin antipyresis.