Proliferation and migration of cells is dependent on polyamines. These compounds consist of 2,3 or 4 protonated amine groups separated by 3 or 4 carbon atoms and bind DNA and proteins at physiological pH. We have found polyamines to be essential for activation and procesing of the EGF receptor and for normal transcription of protooncogenes. In addition polyamines are involved in the cytoskeletal rearrangements necessary fo cell migratin.
Current research focuses on the mechanisms directly affected by polyamiens.
Structural requirements of analogues of polyamines for migration and growth of IEC-6 cells. Wang, J.-Y., H. Wang, and L.R. Johnson. C1474-C1481, December 1995. McCormack, S.A., M.J. Viar, L. Tague, and L.R. Johnson. Altered distribution of the nuclear receptor RAR b accompanies proliferation and differentiation changes caused by retinoic acid in CaCo-2 cells.