Larger vessels can also be treated, but may need surgery, and vascular studies prior to treatment. Side effects are uncommon. They include brown spots or small crusts or ulcerations at the injection sights. If a brown streak occurs along the course of the treated vessel, it will fade without treatment. Some vessels may require two to four treatments before responding completely.
Ankles frequently swell for a few days after they are treated.
Thrombophlebitis of the treated vessel occasionally occurs. Infrequently tiny new vessels develop at treatment sights. They are treated the same way the original vessels were. Rarely, an ulcer may need to be excised in order to speed-up healing. The frequency of treatments is determined by the severity of the problem.