Pharmacological drugs always carry a higher risk and are therefore second choice if there is an orthmolecular alternative treatment. Laboratory tests are not always accurate and blood tests do not necessarily reflect nutrient levels within specific organs or tissues, particularly not within the nervous system. Therapeutic trial and dose titration is often the most practical test. Hence, the search for optimal nutrient doses is a practical issue. Megadoses, larger than normal doses of nutrients, are often effective but this can only be determined by therapeutic trial.
Dose titration is indicated in otherwise unresponsive cases.
Optimal health is a lifetime challenge. Nutrient related disorders are always treatable and deficiencies are usually curable. To ignore their existence is tantamount to malpractice. When a treatment is known to be safe and possibly effective, as is the case in much of Orthomolecular therapy, a therapeutic trial is mandated. Patients are usually reliable.