Drug is usually given at night in case patient needs sedation for side effects.
Solution may be injected into any suitable vein , although injection into tubing of a flowing IV infusion set is preferable to reduce possibility of severe local reactions from extravasation or high drug concentration. Complete injection within a few minutes. Local therapy is used only when malignant cells are found in effusion. Intracavitary injection is not recommended when fluid is chylous. Perform paracentesis to remove most of fluid from pleural or peritoneal cavity.