Applied research is aimed at the development of agents for vaccine and diagnostics development.
Basic research aims at supplementing our understanding of tuberculosis and the interaction between host and pathogen. Together, these projects have given rise to a large number of publications , which detail our findings. The immunology group is working on immune responses to tuberculosis in both human patients and animal models aimed at understanding immune responses in various phases of the disease, as well as the development of immunological memory. In addition, we are developing improved surrogate markers for predicting protective immune responses and testing candidate vaccines and diagnostic reagents. The human inmmunology group is examining in vivo and in vitro responses to individual antigens isolated from M. tuberculosis and the role of cytokines and T cell subsets in these responses.