The Macromolecular NMR Section is part of the Structural Biophysics Laboratory, Division of Basic Sciences, National Cancer Institute. For more information on the PSB, please visit the website . The general goals and projects of the lab deal with the structural biology of proteins involved in signal transduction and regulation of gene expression. A brief description of some of the projects is given here.
Information is also available describing some more technical elements of our research .
The primary targets of our efforts are proteins involved in the transmission of signals between and within cells and proteins controlling gene expression. By investigating the structural biology of these systems, our studies can provide insight into the complex regulation of cell replication, which is crucial to the development and proliferation of cancer. We devote a part of our effort to the development of improved NMR techniques and hardware, as well as protein engineering. These procedures are permitting us to explore larger proteins with NMR techniques. Among our current structural projects, two efforts involve proteins associated with signal transduction, e.g., the SH3 domain in the Hck cytoplasmic protein tyrosine kinase, and the processes of termination and antitermination of gene expression in bacteriophage lambda.