For most women the oral route will be the simplest, cheapest and most suitable form. Oral tablets containing low dose of estrogen are given. The patch is placed on hairless skin over the buttocks or lower abdomen and fixed by palm pressure for 5-10 seconds. It is waterproof and stays in position for 3-4 days. It is useful in women whom the uterus has been removed.
Intrauterine device contains both estrogens and progesterone.
Transvaginal creams and suppositoryy like Dienesteral cream, Premarin cream, etc. It is useful in women with hypertension, hepatobiliary disorders, Increased triglycerides and venous thrombosis. Oral tablets lead to nausea, vomiting and poor compliance. It contains higher doses. Trans dermal patch can lead to local allergic reactions in some women.