Ingestion of ethyl acetate may cause gastrointestinal irritation and, with larger amounts, central nervous system depression. Eye contact with the liquid can produce temporary irritation and lacrimation. Skin contact produces irritation. Ethyl acetate is regarded as a substance with good warning properties. No chronic systemic effects have been reported in humans, and ethyl acetate has not been shown to be a human carcinogen, reproductive, or developmental toxin.
Hazardous gases produced in ethyl acetate fires include carbon monoxide and carbon dioxide.
Carbon dioxide or dry chemical extinguishers should be used for ethyl acetate fires. Reactivity and Incompatibility Contact with strong oxidizers, strong alkalis, and strong acids may cause fires and explosions. In particular, ethyl acetate should be used only in areas free of ignition sources, and quantities greater than 1 liter should be stored in tightly sealed metal containers in areas separate from oxidizers. In the event of skin contact, immediately wash with soap and water and remove contaminated clothing. If ethyl acetate is ingested, obtain medical attention immediately.