There is no doubt organic solvents are harmful to human health. Medically it is under discussion at which concentration the solvent can damage human health. Also under discussion is the potential of different solvents to cause damage. Both are poisonous and reach the environment via emissions, waste water and combustion. They are stored in body tissue by humans, animals and plants.
Humans accumulate lead and cadmium via the food chain and the air.
Titanium oxide is commonly used as a white pigment. It is the most opaque of all whiteners. Pure titanium oxide is a white powder and is considered to be non poisonous. It is a mined product which produces vast amounts of highly poisonous by-products. The only white pigment free of pollutant substances is chalk.