60 mg is an effective analgesic in postoperative pain.
Codeine is an opium alkaloid, with activity similar to, but weaker than morphine.
It is often prepared in combination with aspirin or paracetamol. Oral tramadol versus placebo, codeine and combination analgesics. This information was used to calculate NNT and relative benefit. The meta-analysis was carried out on two postsurgical pain trials and six dental extraction trials. This dose of aspirin plus codeine was significantly more effective than placebo.