The European Registry Of Hereditary Pancreatitis And Familial Pancreatic Cancer Full Bibliography Generalized intestinal polyposis and melanin spots of the oral mucosa, lips and digits. Increased risk of cancer in the Peutz-Jeghers syndrome. . Increased risk of pancreatic cancer in melanoma-prone kindreds with p16 INK4 mutations. BRCA2 that predisposes to a variety of cancers is found in both Jewish Ashkenazi and non-Jewish individuals. A gene for hereditary pancreatitis maps to chromosome 7q35.
Hereditary pancreatitis is caused by a mutation in the cationic trypsinogen gene.
Hereditary pancreatitis and the risk of pancreatic cancer. Lowenfels AB, Maisonneuve EP, Dimagno YE, Gates LK, Perrault J, Whitcomb DC, and International Hereditary Pancreatitis Study Group. Double-strand break repair deficiency and radiation sensitivity in BRCA2 mutant cancer cells. From genes to families. Peutz-Jeghers syndrome is caused by mutations in a novel serine threonine kinase.