Overall, our studies have revealed that placental trophoblast invasion of the uterus is a complex process that requires an exquisite interplay between local microenvironmental factors. Hypoxia stimulates urokinase receptor expression through a heme protein-dependent pathway. Differential display analysis of oxygen-mediated changes in gene expression in first trimester human trophoblast cells. 2-macroglobulin receptor regulates the expression of cell surface plasminogen activator activity by human trophoblast cells. Stimulation of plasminogen activator inhibitor-1 expression in first trimester human trophoblast cells cultured under low levels of oxygen.
Hypoxia stimulates expression of urokinase receptor in human breast and lung carcinoma cells.
Elsevier Science Publishers, Amsterdam. International Federation of Placental Associations.