There is always a tendency to influx where simple substance is active. When there is a disturbance in the inner planes of man's economy there is an influx, from the atmosphere, of some deleterious simple substance. If there were a curative immaterial substance, it would be drawn in by influx and act as an antidote. If remedies are given on the plane of disturbance they will cure. Man is affected in the internals and in every cell.
Every cell has all the planes.
Every cell is what man is as a 'Whole. This elevates the thought to the curative principles. Hahnemann says it is strange that medicine in the old times could not go in the opposite way from that which it took and perceive these things. Crude drugs produce the opposite effects from the attenuated dose. The primary action of a drug represents the effect of the crude drug.