Action - Produces analgesia and reduces inflammation and fever by inhibiting production of prostaglandins. The therapeutic effects are analgesia, reduction of inflammation and antipyesis. Salsalate is the salicylic ester of salicylic acid. Each molecule of salsalate is hydrolyzed to two molecules of salicylate in vivo. Salicylates prevent the lowering of the pain threshold that occurs when prostaglandins sensitize pain receptors to mechanical and chemical stimulation.
Drug also has an ill-defined effect on the hypothalamus.
Exact mechanism of its anti-inflammatory action is unknown. Salsalate splits into 2 molecules of salicylic acid following PO administration and is well absorbed by the small intestine. Rapidly and widely distributed, cross the placenta and enter breast milk. Extensively metabolized by the liver, inactive metabolites excreted by renal system. Hypersensitivity to ASA, tartrazine or other salicylates.