Aspirin has a risk similar to that of ibuprofen. Other side effects include dizziness, ringing in the ear, headache, skin rash, and possibly depression. Such drugs may allow high doses without the accompanying gastrointestinal side effects. It is not an anti-inflammatory agent. Liver and kidney damage are potential serious side effects of acetaminophen.
Alcohol use increases the risk for liver damage.
Experts recommend taking no more than 8 extra-strength tablets each day. Corticosteroids are useful only for temporarily reducing inflammation. They are not a cure, and they offer no long-term benefits. Oral steroids are not recommended. Injections of local anesthetics are occasionally used and can be helpful for temporary relief of severe pain.