Every conceivable observation can be fitted into it. It is thus 'outside empirical science', but not necessarily false. Observed Variation Does Not Accumulate. Despite the rapid rate of propagation and the enormous size of attainable populations, changes within initially homogeneous bacterial populations apparently do not progress beyond certain boundaries under experimental conditions. The anaerobic bacteria, from the bowels of three members of an lt',45 Arctic expedition have survive 140 yrs and are showing resistance patterns to modern antibiotics.
Current theories suggest that antibiotic resistance is linked to long-term exposure to antibiotics.
Macroevolution is decoupled from microevolution. Johns Hopkins Univ. Johns Hopkins Magazine , p.6, June, 1982. You don't make a new species by mutating the species. A mutation is NOT the cause of evolutionary change.