All of the above statements are correct. NNRTase inhibitors are chemically reactive and covalently inactivate the reverse transcriptase. Protease inhibitors prevent the decoating of viral RNA upon the entry of a virion into a cell. Protease inhibitors prevent the proper processing of the viral polyprotein precursor, which is necessary for the proteins to be incorporated into new infectios virions. NNRTase inhibitors are best used alone because they interfere with the action of other anti-AIDS drugs.
Combination therapy is essential to prevent emergence of resistance.
None of the abov e. 16. This is why the nucleoside form is administed, and once in the cell, kinases will convert it to the nucleotide form. None of the statements above are correct. There is no rationale for the use of combinations of nucleoside inhibitors of reverse transcriptase such as AZT or DDI because they all are a chain terminators. Acyclovir is equally good at inhibiting the HSV and HIV viral polymerases.