Test code links throughout this Guide refer to the corresponding test in the User's Guide. Secretion is controlled by ACTH and other pituitary factors. Physiologically, DHEA-S has many roles, including the development of pubic and axillary hair, the development and maintenance of immunocompetence, and as a possible tumor marker. DHEA levels show diurnal variation while DHEA-S does not.
Levels change slowly due to slow metabolism and low renal clearance.
Cushing's caused by adrenal carcinomas where DHEA-S is elevated, but usually not in Cushing's syndrome caused by a benign adrenal tumor. Cohen HN, et al. Clinical value of adrenal androgen measurement in the diagnosis of delayed puberty. Tourniaire J and Pugeat M. Strategic approach of hyperandrogenism in women. Whitley RJ, et al.