As with RBCs platelet production can be increased up to 8x normal if needed. Megakaryocytes undergo endomitosis - a process whereby DNA is duplicated without cell division. Thus MKs become polyploid during amplification. Closer inspection of MKs shows a network of platelet demarcation zones forming fissures throughout the MK cytoplasm. The membranes of this demarcation system eventually formcytoplasmic platelet membranes.
Lysosomes containing hydrolytic enzyme are also present.