Hemolytic anemia associated with lymphoma and chronic lymphocytic leukemia may be precipitated rarely. Erythema multiforme may occur. If accidental eye contact occurs, copiously irrigate area with water, normal saline, or a balanced salt ophthalmic irrigating solution immediately, and promptly consult an ophthalmologist. Use of alkylating agents may be associated with an increased incidence of secondary malignancy, especially with combined use of other antineoplastic agents or radiation therapy. Spermatogenesis may return in patients in remission, but only several years after discontinuation of intensive chemotherapy.
Drug can cause fetal harm.
Drug Interactions None known. The information provided above is based on the manufacturer's official US labeling for this product, last updated February 1997. Inc. All rights reserved.