Avoid use in patients with depressive neurosis or psychotic reactions as paradoxical effects may occur.
Excess sedation associated with benzodiazepines is likely to impair motor function.
Patients should be cautioned to avoid operating machinery or other hazardous activities that require mental alertness and motor coordination. Use with caution in the elderly, as benzodiazepines may worsen cognitive functions and cause mental confusion. Benzodiazepines may worsen motor control in patients with Parkinson s disease. Rifampin may decrease concentrations of benzodiazepines that are metabolized by CYP3A4, including triazolam, alprazolam, midazolam and diazepam. Phenytoin may decrease concentrations of benzodiazepines that are metabolized by CYP3A4, including triazolam, alprazolam, midazolam and diazepam.