Activated by local mediators, neutrophils and tissue macrophages are triggered to release agents that destroy toxins and clean up dead cells in the area. Unfortunately, these same agents also cause collateral damage to healthy cells, which further extends the borders of the initial tissue destruction . Tissue Repair Tissue repair is the third and final stage of inflammation. It may take several days for tissue destruction to reach full intensity before tapering off. Until then, the tissue repair process that consists of growth of new blood vessels and entry of monocytes to clean up the debris is delayed.
Fibroblasts also enter the local tissue to replace the extracellular matrix and collagen.
The process of tissue repair is stringently controlled within the tissue site. If the process becomes dysregulated, inappropriate tissue repair will lead to excessive scarring. Pharmadigm's intravenous drug products are effective inhibitors of vascular inflammation. The benefit of this drug action is less tissue damage and faster tissue repair . In humans, DHEA is synthesized in several organs brain, gonads and adrenals.