As with other AEDs there have been rare reports of pancreatitis, elevated liver function tests, erythema multiforme, Stevens Johnson Syndrome and sudden unexplained deaths where a causal relationship to treatment has not been established, Among the other rarely reported side effects of gabapentin are depersonalization, mania, agitation, paranoia, and increased or decreased libido. Interactions Only a few interactions between gabapentin and other drugs have been identified. This probably is not clinically significant. There is no anticipated pharmacokinetic interaction between gabapentin and phenytoin, sodium valproate, carbamazepine or phenobcirbitone. Alcohol may increase the severity of the side-effects of gabapentin.
Hypersensitivity is a contraindication.
In the USA gabapentin is only approved for use in those over the age of 12. Older people seem to handle gabapentin similarly to younger ones. In various countries Gabapentin is only approved for the treatment of people with seizures. There are no systematic studies that establish the safety or efficacy of gabapentin as a treatment for people with mood disorders. While such studies are in the planning stages, what is currently known about the use of gabapentin for the control of mood disorders comes from uncontrolled case reports.