There have been 2 case reports of elastin being found in the central crater. Treatment of the lesions is unsatisfactory. The lesions are self-healing in any case. There are anecdotal reports of isotretinoin and PUVA being used successfully. Topical steroids are not usually helpful.
Emollients seem helpful in controlling the pruritus.
Experimental production of the lesion. Report of six cases and review of the literature. Acquired perforating dermatosis in a British dialysis population. The perforating disorders. Medicine is a constantly changing science and not all therapies are clearly established.