It seems likely that many uploaded persons would quickly mutate into entities that are no longer human. Virtual Reality Computer generated worlds. Worlds may be personal or shared amongst a number of people. Full immersion VR offers the ultimate in control of sensory experience. Already exists to some degree in the games and in technical applications.
Current simulation is primarily visual and auditory, with some tactile feedback.
Odor and even taste generating devices are being developed. Digital effects for movies have reached life-like quality, but real time scene generation is far behind. Total immersion, real-life quality in all senses will probably not be achieved until machine to brain interfaces are perfected and made commonly available. Total immersion VR will provide so many advantages over physical reality, that a large portion of the population may elect to live permanently in it. Sufficiently strong cryptography may substantially weaken the governments ability to monitor and thus control business and private transactions.