They also noted that this method can be applied to other human chromosomes if large numbers of STSs can be generated for them. The new physical clone map will speed identification of the chromosomal regions involved in these and other diseases after the regions are further localized by genetic linkage or cytogenetic analysis. The map, containing 191 STSs spaced at about 220 kb, was constructed from human YAC libraries having insert sizes of 400 kb to 2 Mb. The work was conducted at laboratories in France, the United States, Spain, and Japan. Childhood Leukemia Gene Researchers constructing a human chromosome 11 physical map consisting of ordered DNA clones have determined the base-pair sequence of fragments spanning the chromosomal region 11q23.
Leukemias arise when immature white blood cells become abnormal and grow and divide rapidly.
Evans and his collaborators studied chromosomes of patients with acute leukemias, which account for almost all leukemia cases among children and young adults. The trx protein regulates the transcription of developmental genes in the fruit fly. The findings suggest that chromosome 11 breakage during translocation disrupts the function of the human trx -like gene and makes it unable to produce a normal protein. Genetic mapping data were assembled into a single publication with chromosomes represented in a common format. According to the Science article, the major difference between a previously published genome map and the new one lies in the number and type of markers used.