I intend to keep it that way. It has been produced successfully, and its patent has also received preliminary approval. I would like to thank Muscle Monthly for offering this opportunity to present the information on this product to you in this forum. Evidence for this in-vivo conversion exists in the literature. Orally active Androgenic steroids are normally not very active orally.
Large amounts have to be taken orally to see biological effects.
This is because the liver first pass causes a massive deactivation of the compounds, primarily through oxidation to17-keto steroids. However, this alkyl derivatization also greatly increases the toxicity on the liver. Luckily another structural modification was found to block the undesirable liver oxidative deactivation and do so in a manner that does not lead to liver toxicity problems. Specifically, we are talking about the introduction of a double bond in the 1- position of the steroid molecule. However, when the double bond is switched to the 1-position, the equilibrium is suddenly shifted in the other direction towards activation of the steroid.