As insulin levels fall, often to levels which would be normal for persons without insulin resistance, the blood sugar becomes elevated. We all know that certain factors affect insulin resistance or sensitivity. Obesity, infections, and cortisone worsen insulin resistance. Exercise and weight loss increase insulin effectiveness. Physicians often see persons with newly-diagnosed type 2 diabetes, who are able to achieve normal blood sugars with diet, exercise, and weight loss, all steps known to reduce insulin resistance.
Experts argue about the toxicity of high insulin levels.
Careful control of blood sugar levels remains the essential aim in the effort to avoid the complications that are such a problem for persons who have diabetes.