There are a number of species, both native and introduced game fish. The introduced fish are the smallmouth and largemouth bass, bluegill sunfish, blue catfish, and rock bass, bluegill sunfish, blue catfish, and rock bass. Brown and rainbow trout are stocked in some of the mountain tributaries. The native fish include black and white crappies, chain pickerel, yellow perch, pumpkinseed, white cat, channel cat, and American eel.
Brook trout are native to a few headwater streams.
On the Potomac, fishing changes from one stretch of the river to another. Deep-water bass fishing can be had near Shepherdstown, mile post 70. Near Harpers Ferry the river below Dam 3 is good for catfish, and bass, near mile post 60. On the river near lock 34 a deep channel offers good crappie fishing in the spring and fall, at mile post 61. Carp and catfish fishing is good near the Point of Rocks Bridge, at mile post 48, and at the mouth of the Monocacy, mile post 42.