The women's ages ranged from the 30's to the 80's. Dr. Lee later expanded the study to 100 women and found that only 3 did not respond to the progesterone cream. Of those 3, one was so depressed over the death of her husband that she had quit eating and exercising. The second woman needed hydrochloric acid supplementation and then gained bone density. The third woman was secretly taking excess thyroid medication, which was corrected and she too gained density.
Excessive estrogen causes swelling in the brain.
Enlarged blood vessels in the brain cause most migraine headaches. Estrogen can also deplete magnesium levels, which make arteries more susceptible to spasm, a common cause of other types of headaches. For most women, it is that simple. If they have pre-menstrual headaches, progesterone cream and magnesium will usually cure them within three menstrual cycles. This is a general overview of the studies on the use of progesterone cream.