Easily and quickly reversed by naloxone. After initial dose, subsequent doses should not be titrated more frequently than q3h or q6h. DOC for aspirin-hypersensitive patients. Different strengths available. Anxiolytics - Patients with painful injuries usually experience significant anxiety.
Anxiolytics allow the clinician to administer a smaller analgesic dose to achieve the same effect.
By increasing GABA, a major inhibitory neurotransmitter, may depress all levels of CNS, including limbic and reticular formation. Monitor patient's blood pressure after administering dose and adjust as necessary. Individualize dosage and increase cautiously to avoid adverse effects. In hospitals without an orthopedic surgeon, transfer to an appropriately equipped facility for operative intervention. The joint should be reduced and splinted prior to transfer.