Radiation therapy can also be utilized for lesions that recur after a primary surgical approach. Careful and prolonged follow-up is required since deep follicular portions of the tumor may escape treatment and result in future tumor recurrence. Carbon dioxide laser. This method may be helpful in the management of selected squamous cell carcinoma in situ. It may be considered when a bleeding diathesis is present, since bleeding is unusual when this laser is used.
Clinical trials are ongoing to treat squamous cell carcinoma with intralesional interferon alfa.
One report shows the combination of interferon alfa and retinoids is effective treatment for squamous cell carcinoma. Nonmelanoma cancers of the skin. Mohs micrographic surgery. Perineural invasion by squamous cell carcinoma. Lovett RD, Perez CA, Shapiro SJ, et al.