Systemic features include fever, malaise, arthralgia, myalgia, abdominal pain, melaena, CVA, neuropathy, hypertension and renal failure. Microscopic PAN is a variant with small vessel vasculitis and focal segmented glomerulonephritis. Investigations include skin biopsy of nodular lesions, sural nerve biopsy and nerve conduction study. Blood test showed raised ESR, leucocytosis with neutophilia, anaemia of chronic disease, hypergammaglobulinaemia, and positive Hep B surface antigen. Renal and visceral artery involvement are demonstrated by small aneurysmal dilatations on visceral angiography.
Death usually results from renal failure.
A more benign form PAN where vasculitis is chiefly confined to the skin only. Treatment includes low dose systemic steroids. The prognosis is good with no significant mortality even without treatment. Frequent involvement of the lung. This site was produced by Teckniq.