Starting dose is 2.5 mg po bid before lunch and supper. CNS effects usually resolve 1-3 days after starting, but if they do not, reduce dose to 2.5 mg before supper. Most patients respond satisfactorily at the 2.5 mg bid dose, but some have been raised to 10 mg bid and tolerated it well.
Adverse effects tend to increase with dosage, however.
When using the higher doses, some amnesia, ataxia and hallucinations have been reported. Category C. Risk cannot be ruled out. Dronabinol should only be used in pregnancy if the benefit justifies potential risk to the fetus. Drug may be habit forming, and mild withdrawal symptoms have occasionally been reported.