We find the boring rectangular restrictions of SimCity and Transport Tycoon to be a problem that is to solve. 3DTT will have them and much more. 3DTT has a real 3D enviroment with vector based coords, in which you can build streets and railroads so free as you can in a CAD program or a level editor of a shooter. There is nothing comparable yet and as we see the commercials seem to not even plan it. Then look how far we came by now.
Factories decide on their own whom to sell their products.
Transport prices editable by player. Passengers and cargo have fixed goals. They only enter vehicles driving toward their direction. Industry and cities grow when they are supplied by their needed goods, increasing demand. Free 3D construction, no tiles.