Well, nothing much has changed in mammals. It is just more sophisticated. Preferably, it should be communicating. Pathogens, by definition, make a mess. The adaptive immune system classifies everything it meets into messy or tidy.
Apoptosis is tidy death.
This downregulation of the basal phagocytic system gives the illusion that the adaptive immune system is primarily designed to combat infection, for immune deficiency leads to infective crises. These grafts were promptly rejected. Yes, the frequency of circulating autoantibodies might be relatively low, but not the frequency of cell-mediated autorejection. CMI reactivity to myelin basic protein occurs after strokes and brain trauma. If they were not, I would not have had to postulate on the presence of a fail-safe cut off to the macrophage aggression induced by adaptive immunity.