Presence of either tachyzoites or toxoplasmal antigens in tissue or smears confirms acute infection. These patients most likely will require hospitalization and subspecialty consultation. Subspecialty consultation is required for the seriously ill patient, according to organ-specific involvement. These 2 drugs work synergistically against the tachyzoite form of T gondii . As an alternative to sulfonamides, clindamycin may be beneficial when used in combination with pyrimethamine.
Limited data are available on the use of pyrimethamine in the first trimester of pregnancy.
Highly selective against plasmodia and T gondii . Does not destroy gametocytes but arrests sporogony in mosquito. Possesses blood schizonticidal and some tissue schizonticidal activity against malaria parasites of humans. Extend regimens to include suppressive cure through any characteristic periods of early recrudescence and late relapse for at least 6-10 wk in each case. Through competitive antagonism of PABA, interferes with microbial growth.