Developing advanced methods for comparing protein motifs. Applying protein motif comparisons for functional and structural predictions and to database annotation. O. Reiner Functional Analysis of Genes Involved in Lissencephaly. Formation of the brain structure in human is a complex process. One of the most striking features of the human brain is characteristic convolutions.
Lissencephaly patients have a severe mental retardation.
Study of LIS1 and DCX function through characterization of protein-protein interactions, and overexpression in tissue culture. Transdifferentiation of neural crest cell derived melanoma into myelinating Schwann cell. Genes controlling cell growth, differentiation, melanogenesis and synthesis of myelin proteins. Chimera and Interferon-beta in neurology, hematopoiesis, and oncology. M. Rubinstein Role of leptin in angiogenesis and fertility.