There is no experience beyond first-day administration of ondansetron. Do not exceed a total oral daily dose of 8 mg. If using with a primary IV fluid system, discontinue primary solution during ondansetron infusion. Gently remove tablet and place on tongue to dissolve and be swallowed with saliva.
Drug has no effect on pharmacokinetics of high-dose methotrexate.
In patients who do not achieve adequate control of postoperative nausea and vomiting following a single, prophylactic, preinduction, 4-mg dose of ondansetron IV, administration of a second IV dose of 4 mg of ondansetron postoperatively does not provide additional control of nausea and vomiting. No overall differences in safety or effectiveness seen between subjects 65 years of age and over and younger subjects. Greater sensitivity of some older individuals cannot be ruled out. No dosage adjustment needed in patients over 65. There is no experience with use of tablets in preventing radiation-induced or postoperative nausea and vomiting in children.