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Arachidonic acid is released from membrane phospholipids as a response to inflammatory stimuli.
Prostaglandins establish the inflammatory response. This mechanism may relate to the variation in response between patients. Scientific studies have shown a correlation between concentration of the drug and effect, but do not explain the differences in individual patient responses. This interaction can enhance either therapeutic or toxic effects of either drug. A trial period of three weeks should be given for anti-inflammatory effectiveness to be observed.