There is an increased urninary excretion of gonadotropins, a substancce acting on or stimulating the organs which produce gametes. Klinefelter males are also characterized by certain physical disorders. They may also have delayed motor function, speech, and maturation development. Klinefelter males are put at a higher risk for other complications. A common complaint is frequent respiratory tract problems including athsma attacks, rhinitis, bronchitis, and pneumonia.
Detection occurs in all phases of the males life.
Prenatal diagnosis is possible by chromosomal analysis of fetal cells gathered via amniocetesis or chronic villus sampling. Language impaiment, difficulty in reading and writing, and passiveness and shyness are clues for detection during childhood. During adolescence, physical development is an indicator like small testes, breast growth, little voice change, etc. Triple-X is found in approximately 1 per 1,000 females. Most all of studies done on triple-X took place in Denmark.