I insert the number of tapes my rotation scheme needs, it does the rest. No muss, no fuss. I like the Backup Wizard and Backup control panels very much. ALL without problems. Backup Exec cannot even utilize an autoloader in a usable fashion, so that's out for us, and ArcServe is so unbelievably unstable that I will never go back to it.
Enterprise is limited to a single backup server with a single tape device.
If you get fed up with ArcServe's limited ability to stream to multiple devices, check out NovaNet8. It can stream to any number of devices you have available simultaneously, without any additional software upgrades, etc. It seems that ArcServe may be more than what I need. I have one server and only certain workstations to back up. From the workstation, it allows you to select NDS as an object to back up on the target server.