Menstrual cycle recovery and elimination of galactorrhea are clinically observed. Hypophyseal imaging by CT or MRI do not reveal any changes in the size of microadenoma. Cabergoline proves effective at comparatively small median dose, and is well tolerated by the patients. 2 diabetic patients should be aimed at restoring normal blood pressure, as well as exerting favorable effect on all cardiovascular risk factors. Doxazosin brings about similar and significant reductions in standing systolic and diastolic blood pressure without evidence of orthostatic hypotension.
Heart rate remains unchanged.
Baseline and steady state immunoreactive insulin remains unchanged. The 24-hour albumin excretion and body weight are not influenced by the treatment. No side effects are registered. Proceeding from the obtained data the conclusion is drawn that Doxazosin apart from being an effective antihypertensive agent, exerts beneficial effect on other risk factors associated with coronary heart disease, including insulin resistance and hyperglycemia. Doxazosin, type 2 diabetes mellitus, arterial hypertension, insulin sensitivity, cardiovascular risk factors.