Everything is manual . You need to remember to do things that were never an issue even with the most manual 35mm camera. As a result, there are more ways to make mistakes than you could ever imagine. The cost per photograph is considerably higher than the same image in smaller format. Think of it as being proportional to the film area.
Depth of field is a serious problem.
Work which requires naturally a high degree of magnification, ie macro and tele-photo, is particularly impractical, the former because of the depth of field limitations, the second because lenses would have to be insanely long. It is impractical to photograph quick action or candids, and even in landscape you'll end up missing optimal conditions. Think a dozen shots or less when you thought a few rolls. Besides, you'll discover by yourself many quirks of Large format photography, like the fact that the dark cloth sometimes tend to fly. This is a photograph of my friend Charles attempting to use a darkcloth for focus and composition on a 8x10 .