Suspected causes include a genetic defect of the X-chromosome, an infection that the fetus develops before birth, or an environmental agent encountered in the womb. This syndrome appears only in females, because affected males die before birth. A CT scan of the head and an EEG may be performed to determine abnormalities of the brain. Symptoms tend to become worse with age and there is a high death rate. There is a better outlook if symptoms are mild and do not appear until adolescence .
Complications vary according to the degree and severity of symptoms.
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