The most important cell to the inflammatory stage as far as tissue healing is concerned is the macrophage . These aid in angiogenesis or neovascularization. Also the macrophage stimulate the migration of the fibroblast in the late stage of inflammation and the early stage of proliferation. If inflammation persisting for months of years due to the wound being chronically sealed by necrotic tissue, is contaminated with pathogens of foreign material that cannot be phagocytized. Epithelialization Mobilization of the epidermal cells.
Epithelial cells migrate from the border in a leap frog fashion or in a train like fashion.
Must have a free edge. Provides a protective barrier to prevent fluid and electrolyte loss and reduce the chances of infection. Wound contracture is initiated during re-epithelialization. Pulls the edges together. Which are responsible for wound contraction.