Japanese Journal of Clinical Oncology, Volume 28, Issue 03, pp. Experimental Chemical Carcinogenesis in the Stomach and Colon Takashi Sugimura , Masaaki Terada National Cancer Center, Tokyo , Japan Experimental chemical carcinogenesis in the digestive tract is reviewed, mainly on the basis of information obtained in the laboratories of the National Cancer Center Research Institute. It is generally accepted that cancer is the outcome of DNA damage, resulting in mutation, loss, amplification and recombination of genes.
Gastric cancer is no exception.
However, this depends on the genotype. Whereas the ACI rat is susceptible to MNNG, the Buffalo rat is resistant and this is a dominantly inherited trait. Genes responsible for the sensitivity to gastric cancer induction are at present under investigation by linkage analysis of rat genome markers. This page is run by Oxford University Press , Great Clarendon Street, Oxford OX2 6DP, UK as part of the OUP Journals World Wide Web service.