The profound impact that it has on sleep affects people in a variety of ways. When people are severely affected, it causes problems during the day, it impacts their ability to work and engage in social activities, and travel. The present mainline drugs of choice for RLS are primarily drugs that mimic dopamine, the neurotransmitter. The drugs that you listed would be further down the line, or adjunct treatments. Frequently a sleep disorder specialist, or a movement disorders specialist would be helpful.
Dopamine is a central nervous system neurotransmitter, which is involved in modulating movement.
Finally, there's a separate line of evidence that links iron deficiency, which has a known relationship to RLS , with modulation of the dopamine system. The first answer would be that Sinemet is an agent that enhances the efficacy of central nervous system dopamine. The latter medication function s by depressing the arousals that occur from leg movements during sleep in RLS, but doesn't totally eliminate these movements. This may even result in patients gradually escalating the dose of Sinemet to unreasonable levels. People can have learned insomnia, or learned difficulty with sleeping, and they need to relearn good sleep habits.