However, the degree of decline in lung function was much less than that expected from the subject s clinical histories. When used with corticosteroids, this hormone also has a synergistic immunomodulatory and steroid sparing effect. Orathai Jirapongsananuruk, M.D. and colleagues from National Jewish Medical and Research Center found that 1,25-OH 2 D 3 significantly decreased lymphocyte proliferation. Lymphocytes are groups of white blood cells of crucial importance to the adaptive part of the body s immune system. The hormone also significantly decreased cytokine production.
Cytokines are protein molecules released by cells in response to activation or injury.
The study assessed the safety of inhaled IL-4R following the discontinuation of inhaled corticosteroids. Investigators compared three doses of IL-4R to a placebo and administered each treatment by inhalation once a week for up to 12 weeks. Overall, treatment with IL-4R was well tolerated and there were no serious adverse events related to the drug. Patients receiving the highest dose of IL-4R experienced asthma control compared to those receiving the placebo. Prior to the study, all patients were dependent on inhaled corticosteroids.