When younger persons have high N, E, or O, or low A or C scores, they should be advised of the natural tendency of these scores to moderate somewhat over the next ten years. On the other hand, persons with extremely low N, E, or O or high A or C scores should be concerned with how to live comfortably with such extremes which could, in fact, become more extreme over time. For two individuals in a relationship, extremely divergent scores on these two dimensions tend to intensify the effects of other differences which under different circumstances might not be so noticeable. This translates, for example, into whether a liberal and a conservative can live in the same household or work effectively on the same team. If one or both is A-, expect fireworks.
Labels can never take the place of the real thing.
The five factor names are an introduction to a much wider realm of discovery. Therefore, whenever time allows, we should prefer to use all thirty facets in our exploration of individual differences, and the five superfactors should only be used as a shorthand to refer generally to the groupings of facets. Even the facets are no substitute for the complexity of the individual human personality and should be treated only as a somewhat more precise descriptor than a factor. When working with a team of people who have only a couple of hours to devote to personality vocabulary, we tend to use the five factors only. As a rough guideline, using the full-facet version with a team of people who have less than three hours to devote to it would not make sense.