Epilogue Six weeks after the revised procedure was in effect, the verdict was in, and almost everyone seemed happy. About 10 calibrations were performed, and most analysts successfully calibrated the system in 1 day. Most were impressed with the robustness of the compositional accuracy tests and the gravimetric autosampler accuracy test. They loved the template documentation but uncovered two minor procedural problems. The calibration administrator is happy with the clarity in documentation.
Management is happy about the time savings.
The instrumental specialist still grumbles about not including tests for instrumental bandwidth and dwell volumes to address the increasing use of narrowbore columns. The committee disagrees with this inclusion at the moment. Life in the pharmaceutical laboratory is increasingly burdened with numerous SOPs and massive documentation. Our three-month sojourn taught us that through active participation and continuous refinement, there is light at the end of the dark tunnel. Acknowledgments Raphael Ornaf, Mark Loranger, and Clark Choi, members of the scientific staff of the Pharmaceutical Analysis Department of Purdue Pharma L.P. in Ardsley, NY, and Jaspal Mayell, consultant, were either members of the team or had significant contributions to this project.