Consider replacing hemostatic blood components as necessary. If unsuccessful may use protamine. Rapid infusion may cause anaphylaxis. Vitamin K 10 mg by slow IV infusion, FFP, prothrombin complex concentrate. Rapid IV infusion may cause anaphylaxis.
Dose depends on severity.
Rapid administration may cause bradycardia, asystole, or seizures. Administer 0.2mg by SLOW IV push. Evaluate patient over next 1 to 3 minutes. If no response, consider other causes of sedation. Oversedation may reoccur in patients who respond.