Some fractures can probably be prevented if careful attention is paid to early diagnosis and treatment of hypophosphatemia, acidosis, and rickets or osteomalacia. About half of boys develop scoliosis, or curvature of the spine, by adolescence or adulthood. The severity of this condition varies from mild to severe. In severe cases, scoliosis can adversely affect mobility and cause back pain and diminished lung capacity. In some cases, this condition is treated effectively through the use of a brace or cast or surgery.
Growth continues, but at a slower ratethan normal.
The underlying cause of the short stature is unknown. Studies are being done to determine the effectiveness and safety of human growth hormone therapy. Reportedly, several children with Lowe syndrome have been successfully treated with human growth hormone. However, the effectiveness and the benefits of the supplementation must be balanced against the significant expense of the therapy and the potential social and psychological factors. The colored lines represent normal growth patterns for boys ages 0-36 months.