RNA replication machinery cleaves specific proteins. NS5B - membranes associated for RNA replication. Infected cell death. Infecting genotype may influence pathogenesis, sensitivity to therapeutics. Rapid evolution leads to immune escape and persistence as well as therapy-resistant variants.
Combination therapy is the most effective for treatment.
Multivalent vaccine is probably required for global protection. Highly conserved, basic. Nuclear localized forms. Anchorage independent growth. Causes tumors in nude mice.