They may be a little more hardy than the guy at the corner liquor store, but today's conventional weaponry is more than enough to overpower most. Certainly the standard weapons available to an evil scientist should be more than sufficient to take care of them. There are a few things to be wary of. Second, the family structures of these creatures are very much akin to secret societies. Particularly in today's cosmetically and medically enhanced populace they can blend relatively easily and may have access to extensive resources.
Individuals still die easily, but watch for revenge killings.
In general, unless you decide to dissect several dozen, they are unlikely to give you much trouble. They've been hunted for generations and are eager to leave people alone in exchange for the same. The most common type of henchman is simply a human who has been psychically or psychologically manipulated into serving the vampire. They often live near the lair of the vampire, perhaps also acting as a mundane butler or caretaker. Like most humans, these guys typically die easily.