Pathologically two major types are distinguished, Type I and Type II lissencephaly and several syndromes are recognised with each type. General problems include marked developmental delay, seizures, feeding difficulties and recurrent chest infections.
Life expectancy is reduced.
Inheritance patterns In most affected persons with MDS and some persons with ILS a deletion can be found on chromosome 17p. The inheritance observed in the other syndromes is autosomal recessive. This is possible in some cases but individual counselling is necessary. The Group is a Contact Group formed in September 1989. Subscription Is payable.