Minor toxic effects. Skin rashes, cough, altered sense of taste, and drug fever. ACE inhibitors are most effective in conditions associated with high plasma renin activity and high angiotensin levels, but are also effective in patients with normal or low levels. The use of ACE inhibitors is contraindicated during the second and third trimesters of pregnancy because of risk of fetal hypotension, anuria, and renal failure, sometimes associated with fetal malformations or death. Doses of ACE inhibitors should be reduced in patients with renal insufficiency.
Concurrent administration can result in hyperkalemia.
Miscellaneous Captopril is slightly more toxic than enalapril and lisinopril.