Occasionally there are reports that cellulite fat has more proteoglycans that lead to more water retention or that there are more or less receptors for various physiologic hormones or proteins, but it does not appear that these are the causative factors. That is why most treatments of cellulite are directed at removal of the cells surgically. Yes, women are more predisposed to cellulite than men. The Rosenbaum study found that women have a much more irregular, discontinuous supporting skin matrix than men do so there is more opportunity for fat cells to extrude into the dermis area. To some extent this must be hormonally controlled through estrogens because most men are not as prone as women to cellulite but men who are given estrogens as treatment for medical problems are known to develop new areas of cellulite.
Fat distribution is different also in women and men.
The medical literature does not support evidence that I could find of any topical creams or ingested medicines or substances that get rid of cellulite unless those treatments result in significant loss of total body fat. In those cases, the dimpling from cellulite becomes less apparent but does not actually go away. Most physician-based treatments are surgical. None of the surgical treatments are directed at fixing the underlying cause but merely fixing the result. Cellulite areas will recur as long as there is any excess fat deposition over the natural metabolic rate.