It was assayed for human activity, by Albert Hofmann in self trials back in 1947, well before this was known to be a natural compound. An I.M. administration of a 500 microgram dose led to a tired, dream state with an inability to maintain clear thoughts. After a short period of sleep, the effects were gone and normal baseline was recovered within 5 hours. Substance - Know your Source. Erowid's dosage information is a summary of data gathered from users, research, and other resources and should not be construed as recommendations.
Individuals can respond differently to the same dosage.
What is safe for one can be deadly for another.