We are also developing new technologies to explore this and other protein machines, for instance new crosslinking techniques. A second division of my group is involved in translational research. Basically we come up with new inventions relative to fundamental problems in biomedicine and try to reduce them to practice. This work is in the context of the Center for Biomedical Inventions, which brings researchers with expertise in wide variety of disciplines together to develop new platform technologies. Relative to vaccines we were involved in the invention of the gene gun, genetic immunization, and most recently a new technique for searching pathogen genomes for optimal vaccines.
Current emphasis is on new genomic approaches to manipulating the immune response.
Relative to targeting we are building off our development of a method to screen phage libraries for peptides that target and mediate uptake into specific cell types. These peptides are the starting point for several new initiatives for platform technologies for isolating new receptors and for delivering drugs and genes. S.H. Reed, W. Huang, E.C Friedberg and S.A. Johnston. The 19S regulatory complex of the proteasome functions independently of proteolysis in nucleotide excision repair . Sub-cellular localization, stochiometry and protein levels of 26S proteasome subunits in yeast.