These effects are usually reversible. Contact with eyes may lead to irritation and tearing. Isocyanate is reported to induce chemical burns in rabbit eye studies. A similar degree of eye injury hay develop after contact with human eyes. However, animal studies have shown that respiratory sensitiztion can be induced by skin contact with known respiratory sensitizers, including isocyanates.
Isocyanates are also strong skin sensitizers.
Experience indicates that direct skin contact is the route of exposure most likely to cause skin sensitization. These symptoms may be immediate or delayed several hours. Prolonged contact can cause reddining, swelling, rash, scaling or blistering. In those who have developed a skin sensitization, these symptoms can develop as a result of contact with very small amounts of liquid material or even as a result of vapor-only exposure. Obtain medical attention immediately.