In some instances, potentiations of CNS and cardiac effects could be life threatening. Dosages should be closely monitored. There have been isolated reports of cardiomyopathy associated with chronic amphetamine use. Anorexia and weight loss may occur. The toxic dose of amphetamine varies widely according to the degree of tolerance present.
Blood levels are, therefore, of little value in assessing the severity of the overdose.
This assessment must depend almost entirely on clinical signs. Central effects may include restlessness, aggressiveness, anxiety, confusion, delirium, hallucinations, panic attacks and even suicidal or homicidal tendencies. The stimulant effect is usually followed by depression, lethargy, exhaustion. Cardiovascular effects may include anginal pain, extrasystoles and other arrhythmias, flushing, headache, hypertension or hypotension, pallor, palpitations, tachycardia. Circulatory collapse and syncope may occur.