Secondary endpoints included time to progression, response rate and duration, safety, and quality of life. Histamine-related side effects included headache, hypotension, flushing, and injection site reaction and were generally mild, transient, and resolved without treatment. These data suggest that the reversal of ROM-induced immunosuppression by histamine may be important in immunotherapy. The combination treatment was well tolerated and did not adversely impact the quality of life. The treatment of metastatic melanoma with chemotherapy and biologics.
Histamine protects T cells and natural killer cells against oxidative stress.
Histaminergic regulation of NK cells. Role of monocyte-derived reactive oxygen metabolites. Regulation of the natural killer cell response to interferon-alpha by biogenic amines. Histaminergic regulation of natural killer cell-mediated clearance of tumour cells in mice. The response of Dunning R3327 prostatic adenocarcinoma to IL-2, histamine and radiation.