A catalytic switch and the conversion of streptokinase to a fibrin-targeted plasminogen activator. The kinetic mechanism of Tritrichomonas foetus inosine 5'-monophosphate dehydrogenase. The roles of conserved carboxylate residues in IMP dehydrogenase and identification of a transition state analog . Expression, purification and characterization of inosine 5'-monophosphate from Borrelia burgdorferi. Isolation and characterization of mycophenolic acid resistant mutants of inosine 5'-monophosphate dehydrogenase.
Hydrophobic interactions control zymogen activation in the trypsin family of serine proteases.
R.J. Structural Origins of Substrate Discrimination in Trypsin and Chymotrypsin. Engineering for Redesign. Residue 172 is a Specificity Determinant. Ground State Binding does not Determine Substrate Specificity. Ching C. A Novel Mechanism of Mycophenolic Acid Resistance in the Protozoan Parasite Tritrichomonas foetus.