A mutation on the gene that determines the coat colour also diminishes mink lysosomal enzymes. As a result, the infected cells cannot destroy the virus. Ferret ADV can persistently infect mink but will not result in histopathologic lesions.
Aleutian disease is probably present in most commercially raised and feral mink.
Aleutian Disease antibody has been found in feral skunks and occasionally in racoons and foxes. Formalin and sodium hydroxide are effective against ADV in the presence of organic material.