The factors that cooperate at an individual CE mostly belong to different classes with respect to the structure of protein domains, namely DNA-binding and activation domain. Thus, composite regulatory elements contribute to the one of the fundumental principles of genom functioning - combinatorial nature of gene transcriptional regulation. The certificate number is N 990002, date of issue 05.02.1999. Evidence for a given CE is an experiment of certain type carried out with two individual interactions within a particular cell type.
Interaction means binding of an individual factor of a certain origin with a particular site.
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