Choose an interesting city as your base and take day trips to nearby sights. Your vacation will actually seem like a vacation instead of a road race. You'll save time, energy and money. Searching for a good hotel can be tiring, and setup time usually takes at least an hour.
Hotels sometimes give a better price, or at least more smiles, for longer stays.
And some private homes don't accept those staying only one night. Day-tripping allows you to travel freely without your luggage. You have peace of mind knowing that you have a room for the night and that your bags are safe in your hotel. It takes more than a day to get comfortable in a place and feel at home. If you are changing locations too frequently, you may never enjoy this rootedness.