Staining and fluorescence characteristics of crystals. Crystals retained their varied forms, including rectangles, squares, needles and irregular polyhedra. One such example was a fibrillar, elongated crystal, measuring approximately 3.9 m in length, recognized by fluorescence in CR-stained sections. Furthermore, profiles of crystals with central linear clearings were apparent. We describe a unique patient presenting with MM and myelofibrosis together with both intracellular and extracellular BM crystal deposits.
Fibroblastic myeloma is uncommon.
Khalil et al. Crystal deposition and inclusions also occur in other types of lymphoproliferative disorders. Occasionally, the crystalline deposits have been widespread, occurring in extracellular locations, such as the glomerular capsular space, renal blood vessels, the myocardium, lungs and other organs. Simultaneous occurrence of marrow fibrosis and crystal deposition is exceptional and, to our knowledge, has never been reported. When bone marrow fibrosis has been reported in MM, it was not always clear whether the two conditions were consequences of each other.