The lymph node status is one of the most important prognostic indicator. In addition, the number of lymph node involved, less than three or four and more, and the amount of metastasis further influence the survival. Tumor cells enter the lymph node via afferent lymphatics.
Extracapsular spread is reported to adversely affect the outcome.
Protein ER positivity is favorable prognostic indicator, PR positivity alone is a weak favorable prognostic indicator. However, laboratory agreement on the type of antibody to use and scoring method is needed. It may influence growth factor receptor and promote cellular differentiation, adhesion and motility. It is detected by immunohistochemical stain on tissue section. C. P-53 Tumor suppressor gene and its protein product is a nuclear transcription factor related to cell cycle regulation and apoptosis.