This sequence is given below. Write the sequence of the probe you have selected in the space immediately below the corresponding amino acids. You may use either a unique or a degenerate oligonucleotide probe. Explain why the region you selected is more suitable for designing a probe than other regions of the sequenced peptide. You are studying a genetic disease called thalassemia, which results in decreased synthesis of the protein -globin.
Further study shows that the only variation in the DNA sequence is found in one of the introns.
Using the data above, suggest a molecular explanation for the defect in -globin protein production observed in the individuals with thalassemia. You have just entered a lab that is generally interested in the evolutionary conservation of developmental mechanisms in different phyla of animals. A group of genes called homeobox genes are known to be important in controlling development in fruit flies and mice. Another grad student has suggested that your most efficient strategy would be to use the polymerase chain reaction.