Therefore these subtypes are eliminated. The blasts cells should be described and identified as Burkitt-like, monotonous, or pleomorphic. Therefore RAEB-t will be eliminated. The molecular genetic associations are defined in Table 5. Other less common translocations have been described as well and are listed in Table 6.
Chromosomal translocations are less common.
Instead, gains or loss of chromosomal material is frequent. In these cases there is strong evidence to link the AML with toxic exposure over a prolonged period. Obtaining a careful occupational history is important, particularly for exposure to benzene and related petrochemicals that may be contaminated with benzene above the accepted maximal thresholds permitted by the federal government or local agencies. A second category includes patients who have received chemotherapy in a curative attempt or in an adjuvant setting, radiation therapy, or immuno-suppressive treatment. Multilineage dysplasia of any degree will be listed under either RARS or RA, depending on the percentage of ringed sideroblasts.