For example, hemoglobin has 287 amino acids in it. Changing just one particular amino acid gives someone sickle cell anemia even if the other 286 amino acids are perfect. Since we have 20 possibilities at each place, the number of possibilities is twenty multiplied by itself some 200 times. This is conveniently written 20 to the 200th and is approximately 1 that is, a one followed by 260 zeros. The great majority of sequences can never have been synthesized at all, at any time.
Informed evolutionists are well aware of the massive problems with their theory.
They have even held conferences like the one at the Wistar Institute several years ago. Dozens of the leading biologists, biochemists, and mathematicians met to try to solve at least some of the difficulties with their precious theory. You would think that conclusions like this would force scientists to accept the idea that there must be a Creator. Unfortunately, there must be a lot of fools in this world. Atheistic evolutionists are gambling their eternal destiny against inconceivable odds.