Chapters 4 - 7 1. Explain why and how the pre-B cell receptor is different from the mature B cell receptor. How does gene rearrangement differ in differentiating B cells with respect to the heavy and light chains. Describe an experiment which demonstrates the principal of allelic exclusion with respect to B cell receptors. Burkitt's lymphoma is comprised of mature B cells.
B cells go through developmental checkpoints during differentiation.
Describe one of these checkpoints and explain how it affects the differentiation process. Using mouse chimeras design an experiment which investigates the process of positive selection of T cells in the thymus. Explain, how the immune response might be functionally altered. Describe an experiment that would demonstrate positive selection of thymocytes. Describe the relevant cells and molecules that participate in this process.