Elements like this generally point to an anatomical renal lesion. Chance, isolated findings of these casts in old people may indicate nephrosclerosis. Moreover it is quite common to find a large number in some cases of heart failure and in hyperthermia, where, in the absence of any other pathological findings in the sediment, they have the same significance as proteinuria. Hyaline casts can be found in all nephropathies, with or without proteinuria. Though they are occasionally an isolated finding, they very often appear in the sediment together with other abnormal components of greater diagnostic importance.
Hyaline casts can have inclusions of various kinds.