The LCT family includes proteins that are derived from animals, plants and fungi. One of the animal proteins is the lysosomal cystine transporter of humans, also called cystinosin, encoded by the CTNS gene.
Evidence suggests that cystinosin transports cystine out of lysosomes in a pmf-dependent process.
Both of these suppressors, when overexpressed, have been reported to influence retention of lumenal endoplasmic reticular proteins as well as glycosylation in the Golgi apparatus. Lysosomal cystine transport. ERS1 a seven transmembrane domain protein from Saccharomyces cerevisiae . Nucleic Acids Res. Expression cloning of a novel suppressor of the Lec15 and Lec35 glycosylation mutations of chinese hamster ovary cells.