A wide variety of adhesion molecules have been characterized on the surface of phagocytic cells and will be shown later.
Cytokines are basic regulators of all neutrophil functions.
Many of them including hematopoietic growth factors and pyrogens have shown to be potent neutrophil priming agents. Cytokines also increase the microbiostatic and killing capacities of neutrophils against bacteria, protozoa and fungi. Furthermore, some cytokines prolong neutrophil survival. Along to cytokines other mediators, including bioactive lipids, neuroendocrine hormones, histamine, and adenosine, are also involved in the regulation of neutrophil activation. Bioactive lipids originate mainly from arachidonic acid which is an abundant constituent of neutrophil membranes.