Many people have attempted to reach the Dome but have died on the way. You need to find a way into the Dome to save yourself. This basic premise plays out well in the game. You can freely go around the world looking for clues and items in your quest to enter the Dome. This freedom of movement suits Take No Prisoners well and lets the player decide what needs to be done instead of being a linear bore-fest.
Locations vary from underground sewers to city streets to train stations to zoos.
Still, no matter where you are, the goal is the same - blow up everything and find an item. No Prisoners are different than what most people are used to. Since it is a top-down game, all the characters are sprites. This really isn't a problem as they are drawn nicely and scale well. What people aren't used to is a 3D world that can only be seen from the top.