Antibody is produced against against this complex and remains inactive in the plasma. When this drug is given it interacts with neutrophil surface protein and complexes antibody. This causes leukoagglutiation or activation of complement. The initial symptoms of neutropenia begin after 1-3 days with malaise, chills, sore throat, fever. Later easy fatigability and weakness are seen.
Infection is the most serious consequence of neutropenia.
Both eosinophils and basophils, like neutrophils, exhibit diurnal variation, being lowest in the morning and highest in the evening.