Globoid cell Epithelioid, often multinucleated cell containing undigested galactocerebrosides, occurs in Globoid cell leukodystrophy also known as Krabbe disease. Hemangioblastoma Usually cerebellar, sometimes hemispheric, brain stem or spinal cord localization, or multiple. Hepatic encephalopathy Metabolic disorder due to hepatic failure, characterized by asterixis, anxiety, restlessness and eventually delirium, seizures, lethargy and coma. This inflammation which regularly features multinucleated giant cells is caused by the human immunodeficiency virus itself and is not an opportunistic infection due to low resistance. Holoprosencephaly Developmental abnormality characterized by incomplete separation of the cerebral hemispheres across the midline.
Facial abnormalities including cyclopia are sometimes present.
Associated with trisomy 13 and rarely trisomy 18. Hydrocephalus Accumulation of excess CSF within the ventricular system of the brain. Hydrocephalic edema is a form of interstitial edema with occurs around the lateral ventricles when there is abnormal transependymal flow of CSF fluid into brain parenchyma. Hydrocephalus ex vacuo Dilatation of the ventricular system with a compensatory increase in CSF volume secondary to a loss of brain parenchyma. Seen with severe brain atrophy for example in Alzheimer s disease.