Reduce triglyceride levels. Reduce VLDL levels. Modest reduction of LDL levels. Moderate increase in HDL levels. Increased incidence of gallstones.
Gemfibrozil is the drug of choice for therapy.
Gemfibrozil, though not as effective as nicotinic acid, is better tolerated. Gemfibrozil should not be given to these patients. Biliary tract disease, pregnant women, obese patients, Native Americans. Gemfibrozil should be used with caution in these higher risk categories. Gemfibrozil potentiates the action of coumarin and indanedione anticoagulants.