The factors involved in regulation are discussed in the following pages. The presentation is somewhat different from that in your textbook in order to emphasize the cellular mechanisms. However, the basic causes of increased and decreased secretion are the same as those on pages 247 and 248 of your textbook. With high dietary intake , there is increased transport into the cells at the basolateral membrane. With low dietary intake , transport into the principal cells at the basolateral membrane is reduced and net secretion apparently ceases.
High levels stimulate transport into the cells at the basolateral membrane.
Low levels decrease transport into the cells at the basolateral membrane. Major diuretics . The reverse is not true in acute metabolic acidosis or respiratory acidosis . Magnitude of electrical potential across the luminal and basolateral membranes of principal cells . The reverse is also true.