Titrate no more frequently than every other day to allow stabilization before escalating dose.
Drug is indicated when treatment with an opioid analgesic is indicated for more than a few days.
This is a third-step drug, which is more useful when the patient requires a constant level of opioid analgesia as a floor or platform from which to manage breakthrough pain. Ingestion of dissolved, crushed, or chewed capsules leads to rapid release and absorption of a potentially toxic morphine dose. Drug bioavailability is not significantly affected by food. Beaker then would be rinsed with additional aliquots of water, as needed, to transfer all pellets to flush the tube. Do not use this method via a nasogastric tube.