Severe cases may progress to include epididymoorchitis in prepubescent males, which can cause atrophy of the testes, but rarely sterility. Mumps can also produce a transient high frequency deafness. Measles is also a systemic infection spread by viremia. Acute disease affects the lymphatic and respiratory systems and occasionally the brain. Measles virus generally enters via the oropharynx.
Local multiplication precedes the viremia and spread to the reticuloendothelial system.
Extensive multiplication produces a secondary viremia 5-7 days later with spread to the mucosa of the respiratory, urogenital or gastrointestinal tracts or the central nervous system. The RS virus initiates a local infection in the upper or lower respiratory tract but illness varies with age and previous experience. The virus infects ciliated epithelia of the nose, eye and mouth and remains generally confined. Virus spreads extracellularly and by fusion. Severe disease may present as bronchiolitis, pneumonia or croup, particularly in infants.