Often becomes clinically apparent within 48 hours of injury. They often herald a big stroke in the area where they occurred. Familial disease, part malformative, part neoplastic. Vasogenic edema Occurs when the blood brain barrier is disrupted. Often occurs focally surrounding areas of infarction, tumor or injury.
Fluid is primarily intercellular.
Additional features may include adrenal pheochromocytomas, renal cysts, renal cell carcinomas, pancreatic cysts and tumors, neoplasms of the epididymis. A complication of meningococcemia and some other Gram-negative sepsis. Seen in early phases of meningococcal meningitis. Massive adrenal hemorrhagic necrosis may lead to severe shock. May be reversible with thiamine administration, occurs primarily in alcoholics, but other causes of malnutrition can cause this syndrome as well.