She also holds an adjunct assistant professorshipat the University of Maryland at College Park. Dr. Trun received her Ph.
Many cellular processes require spatial and temporal coordination ofa complex series of events.
One of the most intricate of these is replicationand segregation of daughter chromosomes. Both projects were initiated by isolating cells that are resistant to thediploidizing agent, camphor. By isolating camphor resistant chromosomalmutants, we have identified a leading strand helicase that functions toregulate the number of replication forks that can traverse the chromosome. By isolating high copy number plasmids that confer camphor resistance,we have identified a three gene system that functions to condense the chromosomeacross actively transcribed genes. The rep deletion cannot be maintained in combination with a deletion of anotherleading strand helicase, uvrD .