We are studying the underlying activation mechanisms of these channels and attempt to identify their molecular nature. For our studies we use a combined electrophysiological and molecular biological approach. The use of an established mouse CCD cell line allows us to directly correlate functional and molecular data in the same system. Moreover, we use Xenopus laevis oocytes as a heterologous expression system. J. Membrane Biol.
Hypertonicity activates nonselective cation channels in mouse cortical collecting duct cells.
Amiloride sensitive sodium channels in confluent M-1 mouse cortical collecting duct cells. J. Membrane Biol. J. Gen Physiol.