Action Inhibits the action of HIV protease and prevents the cleavage of viral polyproteins. Slowing of the progression of HIV infection and its sequelae Increased CD4 cell counts. Distributes into tissues. Small amounts excreted unchanged in urine. Ketoconazole increases saquinavir levels.
Food significantly increases the absorption of saquinavir.
Monitor hematologic and hepatic function prior to and periodically during therapy. May cause anemia, thrombocytopenia, and elevated liver enzymes. Administer within 2 hr after a full meal to increase effectiveness. Taking without food causes decreased blood concentrations and may result in no antiviral activity. Inform patient that saquinavir does not cure AIDS or prevent associated or opportunistic infections.