In normal subjects and in patients with atherosclerotic vascular disease, homocysteine concentrations may be reduced by folic acid either used alone or else in combination with vitamins B6 or B12 4,5,79. The effect is greatest with folic acid. The effect of vitamin B12 when administered alone is more modest if it occurs at all. Since the effect of these measures on vascular morbidity and mortality have not yet been evaluated, the treatment of patients with vascular disease in whom homocysteine concentrations are high remains speculative although some doctors are treating their patients with higher homocysteine levels with folate. I hope you find this information useful.
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