Methods of mass spectrometric analysis that enhance information content to be achieved from materials of unknown organic structure are being investigated. Collaborative investigations on organic ion imaging have been in progress for several years with the objective of spatial localization of organic compounds in tissue. Gas chromatographic- mass spectrometric method for the assessment of oxidative damage to double stranded DNA by quantification of thymine glycol residues. M.P. Heyes, et al. Quinolinic acid and kynurenine pathway metabolism in inflammatory and non-inflammatory disease.
Human macrophages convert L-tryptophan to the neurotoxin quinolinic acid.
Dr. S.P. Markey, Bldg. 10, Room 3D40. NIMH, NIH, Bethesda, MD 20892. Electrospray mass spectrum of myoglobin illustrating data that can be obtained with purified proteins.