The causes of ischemic heart attacks include myocardial infarction, angina pectoris, thrombotic stroke, embolic vascular occlusions, cardiac surgery and heart transplantation. Modern medicine has made it possible to reverse many of these ischemic episodes at an early stage by surgical or pharmacological means, thus limiting infarction and cell necrosis in the ischemic tissues. However the ischemic area may contribute to further tissue damage after reperfusion. The main mechanisms of this phenomenon are formation of oxygen free radicals and calcium overload. However, systemic administration of the enzymatic scavenger SOD has toxicity and low efficiency.
Gene therapy provides a new method for treatment.
Concatamerization of adeno-associated virus circular genomes occurs through intermolecular recombination. Formation of adeno-associated virus circular genomes is differentially regulated by adenovirus E4 ORF6 and E2a gene expression. Yang, J, Qing, J, Yuenzenetc, C. Therapeutic effects of trypsin inhibitor on rabbits with acute heart failure and its mechanism. Journal of Chongqing University of Medical Science.