Consult your doctor for more information. Because St. John's wort and oral contraceptives are broken down and used by the body in the same way, the effectiveness of the oral contraceptives may be compromised. Consult your doctor. It showed that taking St. John's wort at the same time as indinavir greatly reduced the effectiveness of indinavir. St. John's wort may also affect other protease inhibitors in a similar manner.
Caution is advised.
Because the herb's exact mechanism of action is still unclear, it's probably not wise to combine it with MAO inhibitors, medications prescribed for depression and Parkinson's disease. Possible Side Effects Side effects are uncommon but can include fatigue, dry mouth, dizziness, constipation, and upset stomach. Some people experience increased sun sensitivity when taking St. John's wort, especially if they are exposed to the sun for long periods of time. Skin reactions in AIDS patients taking high doses of St. John's wort were so severe in one trial that many stopped participating. So while sun sensitivity is not a problem for most people at commonly recommended doses, be sure to contact your doctor if you develop an unexpected sunburn or rash after being in the sun.