Treat infant for clinically, serologically, or maternally apparent disease with pyrimethamine and sulfadiazine for 1 year. Folinic acid should be given to prevent bone marrow suppression. Recent evidence indicates that those treated for greater than 1 month have better neurologic and developmental outcomes than those left untreated or those treated for only 1 month. Corticosteroid for ocular disease, jaundice, high level of CSF protein. CMV may also be acquired postnatally by ingestion of CMV-positive breast milk.
Infected infants are contagious.
Sensorineural deafness, mental retardation. Virus isolated from urine, pharynx, WBC, CSF, human milk, cervical secretions. PCR has been used to detect virus as well. Recent evidence indicates that ganciclovir given postnatally may reduce incidence of retardation and other sequelae. Consider a pediatric infectious disease or neurology consultation.