It is also hypothesized that body fat levels, endocrine status and exposure to other toxicants can alter the effects of PCBs. One objective of this project is to identify the effects of PCB body burden on endocrines that reflect thyroid function and sexual maturation, and on the physical growth, maturation and cognitive development of children and youth. Another objective is to identify the role of body composition, specifically fat stores, in determining the level of PCBs in circulation and as a modifier of their effects. Exposure to PCBs is determined by serum assay and by dietary questionnaire. This project also collects information on other factors that affect the outcomes of interest and, when necessary, controls them through statisical methods.
Iron status is assessed through blood assay.
Multiple regression techniques, particularly structural equation analysis, of this data permits control of the known influences on the outcomes of interest and the estimation of direct and indirect effects of PCBs on the intermediate and final outcomes of interest. September 1996 Data has been collected for mother and child pairs to identify the consequences of PCBs and other environmental toxins. The project is working on subject recruitment, data collection and quality control. We welcome your comments and inquiries regarding this research project.