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Gemfibrozil is a drug used to lower cholesterol and triglycerides in people with high cholesterol .
Other drugs, especially members of the HMG-CoA reductase inhibitor drug family, are more commonly used. In a randomized study of 21 men with combined hyperlipidemia, ten to twelve weeks of gemfibrozil therapy reduced coenzyme Q10 blood levels to the levels seen in healthy men. The clinical significance of this finding is unknown. The clinical significance of this finding is unknown and may reflect a normal physiological response to a reduction in serum cholesterol levels. Gemfibrozil taken with the prescription drug lovastatin has been reported to cause rhabdomyolysis, a potentially life-threatening muscle disease.