It readily protects rats against traumatic shock and produces deep local anesthesia following parasciatic injections. Acute and chronic schizophrenias, senile psychoses, manic-depressive syndromes. In cases of coma or CNS depression due to alcohol, hypnotics, analgesics or narcotics. It is also contraindicated in patients with blood dyscrasia, hepatic troubles or a sensitivity to phenothiazines. Drowsiness may appear early in treatment but will gradually disappear during the first weeks or with an adjustment in the dosage.
Extrapyramidal effects are rare and usually appear only after prolonged therapy at high doses.
These reactions may be corrected either by reducing the dose of Nozinan or by administering an antiparkinsonian agent. Orthostatic hypotension may be encountered at the start of treatment by the parenteral route or with high oral doses. Rare instances of agranulocytosis have been reported. Weight gain has been occasionally reported in patients during prolonged treatment with high doses. Skin reactions due to photosensitivity or allergies are extremely rare.