Solvents are typically removed from the reaction vessel by application of a slight to medium vacuum. For that purpose a 5 or 10 litres filtration flask is connected by a tubing to the reactor. The SP4000-PRO allows solid phase peptide synthesis on a larger scale. Its reactors are vertically mounted glass cylinders that are equipped with sintered glass filters of large diameter as bottom plates. As solvent reservoirs either 10 litres glass bottles or 70 litres steel drums are available.
Filtration is done by pressurizing the reactor with nitrogen of approx.
The SP4000-PPS is the production scale synthesizer. It is equipped with specially designed reactors of a volume of 30 to 65 litres for in maximum 6 to 8 kilograms of peptide resin. The complete reactor unit stands on a floor scale that is used for the controlling and recording of the addition and removal of solvents. Solvents are pumped directly from the commercially supplied drums into the reactor. They enter the reactor through a shower head and are evenly sprayed down along the reactor wall.