Convulsive seizures have been infrequently reported. However, thioridazine has been shown to be helpful in the treatment of behavioral disorders in epileptic patients. Patients receiving higher doses of phenothiazines for prolonged periods should have complete eye examinations at regular intervals. Patients with liver disease need regular monitoring of liver function. Therefore, thioridazine should be used in women who are or might become pregnant only if the clinical condition clearly justifies potential risk to the fetus.
Limited data suggest that thioridazine is likely to be excreted in human breast milk.
As a general rule, a woman taking a drug should not nurse since the possibility exists that the drug may be excreted in breast milk and be harmful to the child. Phenothiazines may reduce the antiparkinsonian effects of levodopa. Concomitant use of lithium may aggravate extrapyramidal symptoms and neurotoxicity caused by neuroleptic agents. Thioridazine may lower the seizure threshold in epileptic patients. This includes guanethidine, and medicines for high blood pressure, heart conditions, depression, and bladder or bowel spasms.