Dermatologic Disorders Chapter 120. An uncommon bullous disease distinguished from bullous pemphigoid and dermatitis herpetiformis by the linear deposits of IgA in the basement membrane zone. In linear IgA disease, vesicular or bullous skin lesions occur frequently in a herpetiform arrangement. There is a predilection for flexural areas. As in dermatitis herpetiformis, severe burning and pruritus of cutaneous lesions are prominent features, but there is no concomitant gluten-sensitive enteropathy.
Dapsone is the treatment of choice.
Other treatment options include systemic, topical, and intralesional glucocorticoids, cyclophosphamide, azathioprine, colchicine, tetracycline and nicotinamide, and cyclosporine. All rights reserved.