It is estimated that there are about 300,000 Japanese Christians. Dom Pedro Martins abandons Japan. Second invasion of Korea. Luis Frois died in Nagasaki. Tokugawa Ieyasu is appointed shogun.
Dominican missionaries begin working in Japan.
1606 - Dom Luis de Cerqueira is received by Tokugawa Ieyasu. The Holy See opens the Japanese mission to all missionaries. A few dozen priests remain illegally. The coordinating centre of the Jesuits in Japan becomes Macau. The first siege of Osaka, where Toyotomi Hideyoshi and the opponents of the new bakufu are entrenched.