This one is hard to calculate because the cost vary for different treatments. DO be aware of the possibility and plan accordingly. Aslo be aware of the various helath problems a Newf can have. You must remember that big dogs require big toys, big bowls, big crates, etc, which translates into a lot more money. Now, start up cost are always more, so before you get ready to bring that new puppy home, go out and price everything you will need.
Every day is an adventure with a puppy.
The real cost, of course, is paid by our Newfs when a family makes a poor choice. Be honest with yourself. Not just about money, but the whole aspect of owning a Newf.