Acute distress generally subsides in 24 hours or less. Some patients exhibit insomnia, restlessness and anxiety, progressing in severe cases to agitation, mental confusion and incoherence. Hypotension, dizziness, weakness and drowsiness may occur, progressing in severe cases to extreme dizziness and shock. A few patients have displayed hypertension with severe headache and other symptoms. Rare instances have been reported in which hypertension was accompanied by twitching or myoclonic fibrillation of skeletal muscles with hyperpyrexia, sometimes progressing to generalized rigidity and coma.
Gastric lavage is helpful if performed early.
Although tranylcypromine is rapidly excreted, its MAO inhibiting action may continue for approximately 1 week. Treatment normally consists of general supportive measures, close observation of vital signs, and steps to counteract specific symptoms as they occur. Antidepressant Hypnotic Pharmacology Antidepressant Trazodone is a psychoactive compound with sedative and anti-depressant properties. Trazodone is well absorbed after oral administration with mean peak plasma levels obtained within 0.5 to 2 hours after ingestion. Absorption is somewhat delayed and enhanced by food.