The susceptible arm will combine CpG ODN 2006 and Engerix-B and the immune arm will examine the immunomodulator CpG ODN 2006 alone. The development of side effects associated with PI has detracted from what has generally been considered a successful therapy. P 160 will also compare the use of nevirapine given once a day with nevirapine given twice a day. Volunteers must have had no previous anti-HIV medication, except two weeks of AZT, d4T, ddI, 3TC or abacavir, more than three months ago. Volunteers will be randomized into one of three study arms, each involving an interferon-based treatment.
Interferons are natural substances produced by the body in response to viral infection.
Patients with hepatitis C alone are commonly treated with a combination of alpha interferon and ribavirin. Thus the study will consist of a Pegasys alone, a Pegasys plus ribavirin, and an alpha interferon plus ribavirin study arm. The awards may be renewed for up to three years. Have form, will travel For the first time since 1992, the CTN National Office has revised the travel expense form. Derived from the Treasury Board of Canada guidelines and is available in English and French.