If there are no buzzes and you like the feel, cool. If you've got problems with string buzz, slowly add relief until you're happy. With this knowledge, you can sometimes make a neck adjustment before you string up, and it might be correct when you tune to pitch. Removing a bolt-on neck three or four times is not unusual during setup. At the Fender factory they usually get it right in two tries, but they're experts.
Inoperable bridge saddles that require refitting or replacing.
An acoustic bridge that needs to be reglued. A bridge that can't be raised or lowered. The goal is to make the action feel comfortable with your neck adjustments. You may need to readjust the neck while you're setting the string height. It's pointless to final-set the intonation until the action is where you want it.