Having stumbled onto an effective treatment, it seemed appropriate to formulate a theory based on the results. Upon analyzing twenty-four hour urine collections in a few patients, before and after treatment, I found a significant increase in the excretion of phosphate and a moderate increase of oxalate and calcium after guaifenesin was started. I suspected that the body cells of fibromyalgics retain abnormal amounts of substances that should have been excreted by the kidneys. This abnormality, which may be due to an inherited enzymatic deficiency, leads to symptoms fibromyalgics experience in so many tissues and systems of the body. Other researchers have discovered multiple biochemical abnormalities inconnection with fibromyalgia.
Management facts The required dosage of guaifenesin is determined by patient response.
It varies from 300 mg twice a day to as high as 3600 mg per day. Treatment progress is measured both by symptom improvement and by filling in body maps showing the location and size of tender joints, spasms, or hard patches felt in the muscles and ligaments. A key aspect of treatment is that salicylates, contained in aspirin and other compounds, completely block the effects of all uricosuric drugs, including guaifenesin. Moreover, skin readily absorbs salicylates into the body. Salicylates are manufactured by all plants, the choicest parts of which are concentrated to make herbal medications, many cosmetics, and deodorants.