Contains 75 mg of mannitol per 100 mg of cyclophosphamide. Reduce cyclophosphamide dose when using with other cytotoxic agents, if needed. Examine urine regularly for red cells that may precede hemorrhagic cystitis. Advise women of childbearing age to avoid pregnancy.
Drug is usually ineffective in acute blastic crisis of acute granulocytic leukemia.
Contraindicated in patients with severely depressed bone marrow function. Leukopenia develops commonly in patients given initial loading dose and is less frequent in patients maintained on smaller doses. Degree of neutropenia correlates with resistance and infections. Contraindicated in patients who have shown previous hypersensitivity to cyclophosphamide. Drug treatment may not be indicated or should be interrupted or dose may need to be reduced in patients who have or who develop viral, bacterial, fungal, protozoan, or helminthic infections.