It is acknowledged that a number of genetic polymorphisms exist that may effectively influence requirements for folate e.g. making its use less efficient in the body. In the past few years there has been increasing interest in the ability of folic acid supplementation to reduce blood levels of homocysteine, which is considered to be a predictor of cardiovascular disease risk. Consequently COMA does not advocate supplementation for those at risk of heart disease, although the need for further data is recognised. Specific recommendations are not made by COMA, as the existing data are very preliminary. British Nutrition Foundation 2000 Notes to Editors Folate is the umbrella term used to describe natural food folates and synthetic folic acid.
Folic acid is the form used in supplements and to fortify foods.