Well looking after yourself during your flight might be your best bet. Drink lots of fluids while in flight, preferably water. Avoid the coffee and alcohol. They cause dehydration and upset your sleep patterns. Don't eat everything that comes your way.
Gases expand in the air up there.
Your belt will need an extra notch or two by the time you arrive. Get up and take a walk from time to time. If you fly at night, try to get some sleep on the plane. Use the complimentary earplugs and blindfold. Invest in an inflatable pillow.