Deep intra muscular bleeding is common. Overall treatment of haemophilia has become more complex as the risk of HIV transmission in factor VIII replacement, has increased. Prior to screening almost all haemophiliacs became H.I.V. positive. Large levels of factor VIII are required to offset the inhibitors. This is the most common malignancy of childhood.
Management includes chemotherapy.
Sickle Cell Anaemia Sickle Cell disease usually manifests when the afflicted child is aged 2-3 years. It usually leads to bone infarctions. Hydroxyurea has produced dramatic pain relief for bone crises. Gaucher's Disease also known as Familial Splenic Anaemia. It is an aberrant AR lysosomal storage disease.