Autosomal recessive disorder involving the dysfunction of all exocrine glands. Mutation in the long arm of chromosome 7. Abnormal mucous secretion, particularly in the lungs and gastrointestinal system due to deficiency of the transport mechanism of chloride.
Electrolyte abnormalities are common.
Comprehensive management plan including aggressive use of antibiotics, chest physiotherapy and nutritional supplementation including pancreatic enzymes. Introduction Cystic fibrosis is the most common lethal genetic disorder affecting caucasians. We report the prenatal manifestations of cystic fibrosis in both fetuses of a twin pregnancy. Ascites in twin B had been initially detected at 13 weeks gestation. Her medical and family history were negative.