Use with caution in patients with a history of pancreatitis. Hyperuricemia, hyperglycemia, hypercholesterolemia Hyponatremia, hypochloremia, hypokalemia, hypomagnesemia Hematologic disorders including neutropenia, thrombocytopenia and agranulocytosis. Ethacrynic acid may contribute to the potential ototoxicity of aminoglycosides. Ethacrynic acid may increase the potential for gastrointestinal bleeding with corticosteroids. Ethacrynic acid may increase lithium concentrations.
Ethacrynic acid can displace warfarin from plasma protein.