This is most needed when traveling East as it is harder to set your clock back than ahead. Secondly, melatonin serves to protect the brain against oxidative damage. During air travel, you are exposed to higher than normal amounts of ionizing radiation since you are above some of the protective ozone layer. Melatonin also regulates some areas of immune function in the central nervous system. Along these lines very high doses of melatonin is being used experimentally as an adjunctive therapy in treating cancers originating or metastasizing to the brain.
Information is provided for educational purposes only.
It is not intended as diagnosis or recommendation for treatment of disease. Please consult your physician for medical advice.