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Intrathecal trial is open for enrollment.
An earlier, large trial of BDNF delivered subcutaneously wasn't effective. Amgen and Regeneron are now testing the drug by putting it directly into the cerebrospinal fluid. The intrathecal pump is made by Medtronic. Amgen and Regeneron also plan to test subcutaneous delivery in an undefined subgroup of ALS patients whom they believe may benefit from this delivery method. Amgen Neurotrophic Factor Shown to preserve motor neurons in laboratory situations where they would otherwise die.