You can only be accurately diagnosed and properly treated by a health care professional. Information on this page is provided courtesy of Oklahoma State University and is intended for information purposes only. Overview One of the major events during inflammation is the movement of cells from the blood stream to the site of injury. As science has progressed, the concepts of how inflammatory cells get to an inflammatory focus have drastically changed. For instance, it was once thought that margination and pavementing of leukocytes along endothelial surfaces was secondary to increased blood viscosity and rouleaux formation by erythrocytes.
Leukocytes marginate along and adhere to endothelial surfaces.
The disease entity is called bovine granulocytopathy syndrome in cattle, and leukocyte adhesion deficiency in Irish setter dogs. Leukocyte Emigration Emigration refers to the process by which leukocytes escape from their location in the blood to reach the perivascular tissues. Once in contact with endothelium, the inflammatory cell extends pseudopodia through gaps in endothelia. The gaps are created through the action of chemical mediators on endothelium. Once through the endothelium the leukocytes may be delayed passing through the basement membrane and pericytes.