An extended period of IV antibiotics were clearly life-saving, and she significantly improved. This case was subsequently published with Dr. Fallon in Psychosomatics. Over time, I have seen hundreds of Lyme disease patients with a broad range of symptoms effecting CNS functioning. Very consistently, most of these neuropsychiatric patients show CNS Herxheimer reactions followed by improvement in response to antibiotic treatments. L et's step away from clinical observation, and instead look at disease from a more abstract view.
Darwinian medicine looks at causes of disease from an evolutionary perspective.
One view is that microbes evolve faster than humans, and as a result infectious disease will always exist. Most disease is a result of a unique combination of a vulnerability and an environmental circumstance. One theory is that we are genetically adapted to stone age life, but are living in a very different environment. Such a view has complex implications, and can readily explain problems such as fear of flying. However, some other mental illness appears to be a failure of regulatory systems as a result of some type of neural injury, and dysfunction from infectious disease.