In many people, personal loss or severe stress is identified that may interact with a predisposition to depression. The causes may include genetic, familial, biochemical, physical, social, and psychological factors.
Major depression occurs in all groups of people.
It affects both sexes, with an increased incidence in women. Major depression affects 1 out of 10 Americans at some point in their lives. Treatment, including medications and psychiatric intervention, may prevent recurrences. Lithium and thyroid supplements often enhance the effectiveness of antidepressants. Electroconvulsive therapy is a psychiatric treatment that causes a central nervous system seizure by means of an electrical current.