Secondary lymphedema is precipitated by an event causing blockage or interruption of the lymphatic vessels. In the United States the most common causes are surgery involving the lymph nodes, radiation therapy, trauma, and cancer. It is most often seen following surgery for cancer of the breast, pelvic area, and resections for lymphomas and melanomas. As lymphedema progresses, the involved areas swell more and more. Mobility can be severely impaired as the affected areas increase in girth.
Joint movement is restricted and painful, and the skin over the involved areas becomes taut and dry.
The subcutaneous tissues can become hard and fibrotic which impairs the flow of blood and oxygen to the area. This unhealthy state often leads to recurrent infections because the high protein lymph fluid is a good growth media for bacteria and fungi. These infections can be life threatening and may require hospitalization for intravenous antibiotic therapy. Each subsequent infection can further damage the already impaired lymphatic system.