Calcium transients in neonatal rat myocytes. Numbers indicate nanomoles of systolic calcium. The main feature to notice is the increase in calcium concentration, in this case, a rise in systolic calcium from 350 nanomoles to 700 nanomoles. Numbers are included due to a change in scale. In response to alprenolol, calcium transients are rapidly reduced to a point that control of calcium movement and response to pacing is lost.
Isoproterenol increases heart rate and acts as a vaso- and bronchodilator.
Cells were fluorescently labeled by a 30 minute exposure to Calcium Green in serum-free medium. Cells were photographed using a Molecular Dynamics Confocal Laser Scanning Microscope. The striated pattern is the calcium wave moving through the beating cell. Photography by Mark Snuggs. Cytokine treatment following exposure to isoproterenol did not produce the normal increments expected from beta-adrenergic receptor stimulation.