The exposure standards for these three compounds will also be included. Metabolism of HP will also be described. Repeated Dose Repeated dosing involves more than one intermittent exposure or continuous exposure greater than one day. The route of exposure is usually oral or inhalation. Inhalation exposure is for 2 to 8 hours per day for x number of days or is a continuous exposure for a given length of time.
Inhalation exposure can be to the vapor only or to an aerosol, which also involves vapor as well.
There is no repeated dermal dosing data from exposure to liquid HP on the skin. Chronic Chronic exposure in a toxicology test is a repeated dose that is received for longer than 90 days, preferably one year minimum. Carcinogenicity Pathology of stomach and intestines in mice exposed long-term may progress to cancer. In rats only non-malignant papillomas of forestomach are found, not malignant tumors. HP is not an initiator of skin cancer but may be weak promoter of skin and intestinal tumors.