Its onset and duration of action depends on the kinetics of aldosterone response in the target tissue.
Inactivation occurs in the liver.
Indications Potassium-sparing diuretics are commonly used to help reduce the amount of water in the body. Unlike some other diuretics, these drugs do not cause the body to lose potassium. Spironolactone is also used to treat hypertension. If the condition is prolonged for a long duration of time, the heart and arteries may not function properly. This can damage the blood vessels of the brain, heart, and kidneys, resulting in a stroke, cardiac failure, or renal failure.