Perhaps as remarkably, SPES is more effective than morphine for cancer pain and it has almost no side effects. It is also almost totally effective against fatigue, weakness, loss of appetite, insomnia and nausea. PGE2 has a number of nasty effects such as causing inflammation, damaging immune function, stimulating tumor growth and causing blood clots. B-endorphins are the body's own pain killer. It is usually very reduced in the brains of cancer victims.
Enkephalins are also pain killers.
Ach is a neurotransmitter involved in memory and increased mental functioning as well as pain reduction. SPES was able to effectively inhibit the wave amplitudes of P250-260 and prolong the latent periods. SPES reduces substance P which promotes tumor growth and also acts as a pain transmitting substance. This causes an inhibition in pain signal transmission. High cAMP also normalizes cell division and helps turn cancer cells back to normal.