Tachycardia, anorexia, edema, palpitation, blurred vision, chills, urinary retention, sweating, impotence, tinnitus, muscle spasm and tremors, paresthesia, skin rash and mild jaundice have been reported in rare instances. Serious hypertensive crises may occur in patients receiving tranylcypromine. Either tachycardia or bradycardia may be present, and associated constricting chest pain and dilated pupils may occur. Intracranial bleeding, sometimes fatal in outcome, has been reported in association with this paradoxical increase in blood pressure. If a hypertensive reaction occurs, discontinue the drug and institute hypotensive therapy.
Headache tends to abate as blood pressure lowers.
Do not use reserpine or rauwolfia alkaloids parenterally as they may, paradoxically, increase hypertension. For milder reactions injectable chlorpromazine may be indicated. These drugs should be administered with caution in order to avoid producing an excessive hypotensive effect. Fever should be managed by means of external cooling. Other symptomatic and supportive measures may be instituted if required.