To interpret the data from these experiments a robust algorithm must be developed to estimate the parameters of an activation model. The objective is to minimise the timing differences between the model predicted activation sequence and the experimentally recorded sequence. We have found that the mechanical properties of passive ventricular myocardium are distinctly orthotropic, rather than transversely isotropic as has been generally assumed. This project would continue the development of the interface between the experimental rig and parametric model, using a latex rubber membrane as the test sample. The electrical and mechanical aspects of heart function are closely coupled.
Electrical signals initiate mechanical contraction and control the strength of that contraction.
Mechanical deformation in turn alters the pathlengths for electrical propagation and also directly affects the conductance of the ion channels in the cell membranes. This area of research is becoming a major focus of the bioengineering group. The aim now is to begin using this model in a more diagnostic way. The two clinically important areas that would be investigated initially are the diagnosis of epilepsy and the interpretation of evoked auditory potentials. While much progress has been made, the underlying mechanisms are not well understood.