Patients excluded included those with more than 12 MPS disc areas of CNV by fluorescein angiography, concurrent eye disease potentially affecting acuity. Additional exclusion criteria are extensive. Please read the article for the long list of excluded conditions. For the most part these patients were very healthy with no or few comorbid conditions. All four groups received matching vials.
Blinded reviewers read serial angiograms.
481 patients were enrolled in 45 centers over a 9 month period. 25 were withdrawn because their angiograms excluded them from inclusion. The statistics are inconclusive regarding the effect on vision. Apparently, angiogenesis is a very important natural process required for life irrespective of the eye. Examinations were performed in vivo by direct observation of fluorescence by ophthalmoscopy, using excitation-barrier filters.