The two cytokines which are believed to play a major role in Rheumatoid Arthritis are interleukin-1 and tumor necrosis factor alpha. These two cytokines produce collagenase and other proteases that destroy the cartilage. The factors that activate the macrophages to produce these cytokines include bacterial and viral products, immune complexes, complement components, and cytokines themselves. These oils are comprised of docosahexaenoic acid and eicosapentaneoic acid. They make prostaglandins of the E-3 series.
Glucosamine sulfate is needed by our connective tissue.
It is part of the cellular cement and is elevated in our joints affording protection against the destruction of the joints. Proanthocyanidins are plant flavonoids that have exhibited extremely high antioxidant activity. Free radical activity is implicated in cartilage damage and arthritis, flavonoids have potential to slow inflammatory conditions of Rheumatoid Arthritis. Flavonoids improve capillary integrity and stabilize the collagen matrix. Hawthorn berries and grape seed extract are high in proanthocyanidins.