These methods are not very high throughtput. The models are conformationally dependent, alignments to standards are necessary. Experimental ADME Screening CaCO2 is now relatively easy to run in high throughput. Most large companies are able to introduce this HTS experiment early in drug discovery. Human liver cells can be stored for at least a year but relies on donations of cells.
Liposomes are easy use for high throughput screening but give misleading results.
That is, liposomes may indicate pathways that would not be found in hepatocytes and may lead a chemist in the wrong direction. For example, the same enzyme may hydroxylate a compound in two locations and the inhibitors of one hydroxylation may not be the same as the other hydroxylation. Because of HTS ADME screens and the selection of more compounds for preclinical tests, a backlog is developing for ADME services when more extensive testing is required. Absorption Technologies offers a more value-added approach using a panel of screens. Pharmacogenomics Drug-Drug interactions will be increasingly important to the FDA and to physicians.