Major Hazards Highly flammable. The acute toxicity of acetone is low. Unacclimated volunteers exposed to 500 ppm acetone experienced eye and nasal irritation, but it has been reported that 1000 ppm for an 8-hour day produced no effects other than slight transient irritation to eyes, nose, and throat. Acetone is practically nontoxic by ingestion. Acetone is slightly irritating to the skin, and prolonged contact may cause dermatitis.
Liquid acetone produces moderate transient eye irritation.
Acetone has not been found to be carcinogenic in animal tests or to have effects on reproduction or fertility. Carbon dioxide or dry chemical extinguishers should be used for acetone fires. In particular, acetone should be used only in areas free of ignition sources, and quantities greater than 1 liter should be stored in tightly sealed metal containers in areas separate from oxidizers. In the event of skin contact, immediately wash with soap and water and remove contaminated clothing. If acetone is ingested, obtain medical attention immediately.