Works on serotonin release instead of blood vessel spasm, and may provide relief in less than 20 minutes. It can increase blood pressure. It may cause spasm of muscles in jaw, neck, shoulders and arms. Frequent use of Imitrex may cause a rebound reaction, worsening migraines. It also reduces muscle spasm frequency and myoclonus.
Effective dosage varies considerably in patients.
May cause drowsiness. They block cyclooxygenase-2, an enzyme that helps create enormous mounts of prostaglandins. All Rights Reserved.