Eventually, affected ewes become depressed, weak and have poor muscle control. In latter stages, they lie down and are unable to rise. If left untreated, coma and death result. The most common treatment is to drench ewes with 2 to 3 ounces of propylene glycol 2 to 3 times daily. Yogurt mixed with water will also provide energy and bacteria to stimulate the rumen.
Intravenous glucose is another possibility, but harder for producers to do on the farm.
Antibiotics can be administered to prevent pneumonia. In advanced cases, a caesarian section may need to be performed to remove the fetuses and save the ewe's life. If the lambs are near term, oftentimes, they too, can be saved. The nutrition of the entire flock should be suspect anytime a ewe shows indications of pregnancy toxemia. Of course, like other diseases, it makes more sense to prevent pregnancy toxemia than to treat it.