First of all, remember that those are normal feelings and acknowledge them. Next, find someone to discuss your feelings with so that you have the opportunity to express them. Once the feelings are expressed, it is important to try to analyze which things are bothering you the most and pick one to work on. Finding a solution to something keeps you from constantly burdening others. You certainly are not alone.
Many communities have support groups for the caregivers.
Some communities even have programs where individuals will assume some care tasks to allow the caregiver to have a break. Fatigue is a problem and usually your body will tell you when to quit. In most cases you can do more than you think and your body will say when to halt. Learning to live with ESRD is a challenge but the key is learning to LIVE with it and not just exist with it. Fatigue is a state when physiologically the body does not have the resources to continue activity.