Atrophy- caused when a muscle is immobilized or has lost its nerve supply. Proliferation Phase - marked by removal of the debris and temporary repair tissue formed during the inflammation stage and by the development of new, permanent replacement tissues. Regeneration - occurs when the new cells are of the same type and can perform the same function as the original structure. E.g., dermal tissues. Replacement - results when a different type of cell replaces the damaged cells.
Excessive amount leads to scar tissue development.
Macrophages and polymorphs, which can withstand low-oxygen environments, begin to laydown capillary beds. Fibroblasts begin laying down collagen to form a seal over the injured structure. Wound Contraction - occurs following the revascularization of the injured area. Also begins at the periphery and moves to the center of the injured area. Fibroblasts produce weak type III collagen.