Adults are usually within normal height parameters. Inheritance patterns Most cases are sporadic mutations. Once established inheritance is autosomal dominant. Weaver syndrome inheritance probably has some pattern of inheritance though this has not been fully determined. Pre-natal diagnosis Macrocephaly, large hands, long arms and excessive growth are detectable using ultrasound scanning.
Genetic counselling is available for affected families.
The information below has been drawn up by Dr Orlee Udwin of the Society for the Study of Behavioural Phenotypes. Psychological and Behavioural Characteristics Attainment of early motor and language milestones is usually delayed in individuals with Sotos syndrome. Marked clumsiness, an unsteady gait and poor co-ordination are common, though these difficulties tend to improve somewhat with age. Language problems include echoing of words and phrases, perseverative responding, stammering, and difficulty controlling the muscles involved in vocal production. Most individuals having mild or borderline learning difficulties, though intellectual abilities can range from severe learning difficulties to average intelligence.