Your clinical situation is not unique. Many folks find themselves in this dilemma. Both options obviously have pluses and minuses. Toxicities and complexities of these kinds of regimens have limited their utility. A third of patients get serious adverse events, and more have to stop because of side effects.
Clinical trials are an option.
You need to separate trials with new agents and trials with old drugs recycled. If you can get on a trial with a new drug or a couple of new drugs that are guaranteed to have activity in you, this may be the better route. If only one new drug is used with a couple old ones that you are resistant to, it's probably not worth it. If the study is recycling old drugs to which you are resistant, it's not worth the travel. Experts appearing on this page are independent and are solely responsible for editing and fact-checking their material.