Moreover, the role of growth factors in preventing cytokine induced parenchymal damage and its effect on inducing differentiation of stem cells following a brain contusion is investigated. The number of microglia cells has been found to increase in an area with central or peripheral neural damage. The cells have been found to produce neurotoxic factors. The effect of specific inhibitors of these toxins following central and peripheral nerve damage are studied. An interaction between glia cells and neurons following trauma or cerebral haemorrhage has been shown to increase the amount of intracellular calcium in the neurons.
Intracellular calcium can reach levels where it is life-threatening to the nerve cells.
The neurons seems to have a selfprotecting mechanism in the form of a calcium binding protein produced intracellularly. The possibility for increasing the synteses of the intracellular calcium binding protein following trauma or cerebral haemorrhage is investigated.