The patient and injection site is examined every 15 min for one hr. However, a negative test does not guarantee a reaction-free administration. Therapy should be discontinued if severe thrombocytopenia or leukopenia occurs. Nausea, diarrhea, stomititis, GI bleed. No pharmacokinetic drug interactions have been described.
Excessive immunosuppression can occur when used in combination with other immunosuppressive agents.
References Brennan DC et al A randomized, double-blinded comparison of Thymoglobulin versus Atgam for induction immunosuppressive therapy in adult renal transplant recipients. Current use of polyclonal antilymphocyte antibody preparations.