The construction and design of the enclosure must prevent escape. The enclosure also must be free of sharp edges and other potential hazards. The enclosure must be roomy enough to allow normal activities and breeding, if the latter is desired. One reference recommends at least 100 square inches of floor area per adult, whereas breeders should be allowed 180 square inches per animal. The enclosure can be open at the top, provided that its sides are at least 7-8 inches high.
Males tend to be more rambunctious.
Furthermore, a leg may be broken if it becomes entangled in the mesh. This is most often a problem with guinea pigs that have not been reared on wire mesh, and occurs soon after they have been introduced onto it. Enclosures that provide solid flooring and an adequate supply of a preferred bedding are best for pet guinea pigs. Bedding must be clean, nontoxic, absorbent, relatively dust-free and easy to replace. Shredded paper, wood shavings, and processed corn cob are preferred bedding materials.