It drains 1432 km2 before draining into the Mississippi River. Much of the downstream portion of the watershed is heavily urbanized. Sportfishing, boating, duck and goose hunting are all popular. The Loosahatchie River watershed contains parts of Fayette, Hardeman, Shelby and Tipton Counties and drains 1911 km2 before emptying into the Mississippi River. The watershed supports cotton, soybean and some corn production as well as duck hunting.
Fishing is extremely limited.
The Nonconnah Creek watershed contains part of Shelby County and drains 477 km2 before emptying into the Mississippi harbor channel. The watershed is heavily urbanized and supports some commercial nurseries, but very little recreational fishing, hunting or boating. The Forked Deer River watershed flows through parts of Dyer County and drains 186 km2 before emptying into the Obion River. Farming and hunting are common in this small watershed. The Obion River watershed contains parts of Dyer, Gibson, Henry, Lake, Obion, and Weakley Counties and drains 3626 km2 before emptying into the Mississippi River.