It was not designed to protect us from a more chronic blood pressure drop such as progressive heart failure. The re-routing of circulation produced by Angiotensin II leads to more blood returning to the heart and more blood for the heart to pump forward. The failing heart cannot handle this extra work and will fail more rapidly. Enalapril effectively acts as a dilator of blood vessels. This effect opens up circulation peripherally.
Blood pressure drops and the heart has less work.
USED Enalapril is used in the treatment of high blood pressure and in the treatment of congestive heart failure. In humans, there is evidence of a protective effect for the kidneys in certain situations. This effect requires further exploration in animals as enalapril paradoxically can lead to kidney damage as its vessel constricting activities reduce blood flow to the kidney. Enalapril may be given with or without food. Despite approval as a once a day medication, usually enalapril must be given twice a day.