The appropriate dose will offer a high level of protection against osteoporosis. You can stop taking it immediately if it doesn't suit you. You are responsible for your own medication. You may experience breakthrough bleeding if you forget to take a tablet. May be unsuitable if you have a history of high blood pressure, blood clotting, or liver disorders.
Injected estrogen goes directly into the circulation without first passing through the liver.
This has both good and bad effects. There is also some question about the predictability of absorption rates. The main drawbacks of intramuscular injections, however, are the discomfort of regular injections plus the peaks and valleys of estrogen levels that such a system inevitably produces. A medicated adhesive is attached to your abdomen, where it releases estradiol, a pure form of estrogen thought to be less cancer causing. Estradiol bypasses the liver and is best for women who can't take HRT orally but who have severe hot flashes and vaginal problems.