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Although the gain in longevity may seem surprisingly small, the finding reflects the difficulty of pushing back the boundaries of old age, the researchers said. Even if people escape the No. 1 killer, a host of other ailments are likely to take its place as people reach their 80s and beyond. Similar analyses of cancer have concluded that life expectancy would increase about two years if that disease were conquered. Heart disease kills about 500,000 Americans annually. The average life span in the United States has risen from 47 in 1900 to 75 today.