Do not give as IV push or bolus. If hypersensitivity or an infusion-related event occurs, temporarily slow or interrupt therapy.
Infusion can continue at one-half the previous rate upon improvement of patient symptoms.
There are limited data concerning use of more than two courses. If patient did not tolerate the first infusion well, follow guidelines under first infusion. Do not give as IV push or bolus. Do not mix or dilute with other drugs. Premedication may attenuate infusion-related events.