Turn off Virtual Memory in the Memory Control Panel in the Apple menu. Turn off AppleTalk in the Chooser in the Apple menu. Build an extension set using the Extensions Manager control panel with the minimum set of extensions needed to run Bliss Paint. Turn off Buffer Paint Window and Sequence Tracking in Preferences in the File menu. For slower cycling try values in the range of 4-8 ticks or so.
Longer intervals make for a stop motion or stepped feel for another effect.
Turn on Ignore Outside Apps in the Bliss menu. Sound input can also be used to trigger Bliss Paint's color synthesizer. Volume is mapped onto one of the color oscillators. Options can be controlled in the Configure Sound dialog of Bliss Paint. There is an Octopus mode with many different Bliss Paint features mapped to MIDI controller messages.