Adjust dosage according to severity of pain and patient response.
Drug is less effective when used orally than when used parenterally.
Contraindicated in patients hypersensitive to meperidine. Neurologic signs of further increases in pressure in patients with head injuries may be obscured. Use extreme caution and only if use is essential. In such patients, even usual therapeutic doses of narcotics may decrease respiratory drive while simultaneously increasing airway resistance to the point of apnea. Drug may aggravate preexisting convulsion in patients with convulsive disorders.