Yes, big disadvantages. One of the biggest mistakes people make is to take 3 tablets at once instead of spacing them out over the course of a day. Your body can only absorb so much at one time. If you take all of this at once, the product may not be as effective as when you split up the doses. I can't stress consistency enough.
Good health is work.
You have to be willing to spend the time to make it work. I have found in my practice that people who smoke have more painful symptoms than their non-smoking counterparts. In my experience, patients who remain active experience less pain than inactive patients. Using light weights can also be beneficial. This is where dietary supplements can help stop a vicious cycle.