Clinical trials have demonstrated that the cefoxitin regimen is effective in obtaining short-term clinical response. Fewer data support the use of ceftriaxone or other third-generation cephalosporins, but, based on their similarities to cefoxitin, they also are considered effective. Ofloxacin is effective against both N. gonorrhoeae and C. trachomatis. Clindamycin, but not metronidazole, further enhances the Gram-positive coverage of the regimen. Alternative Outpatient Regimens.
Information regarding other outpatient regimens is limited.
Patients who do not demonstrate improvement within this time period usually require further diagnostic workup or surgical intervention, or both. If the provider elects to prescribe outpatient therapy, follow-up examination should be performed within 72 hours, using the criteria for clinical improvement previously described. 6 weeks after completing therapy. Management of Sex Partners Evaluation and treatment of sex partners of women who have PID is imperative because of the risk for re-infection and the high likelihood of urethral gonococcal or chlamydial infection of the partner. When this is not feasible, health-care providers should ensure that sex partners are appropriately referred for treatment.