If only total catecholamines, total metanephrines, vanillyl mandelic acid, dopamine as well as homovanillic acid are determined, results show poor diagnostic sensitivity. For that reason, more sensitive analytical procedures and biochemical markers are required, having the lowest rate of false positive results. By employing new highly specific enzyme immunoassays, these disadvantages are overcome. The results obtained are reliable, of high precision as well as free of drug interferences. Dopamine has shown insensitive for Noradrenalin and Adrenalin screting phenochromocytomas.
Literature is available on request.
For the internal urine accuracy control we recommend the Bio-Rad Lyphochek Urine Controls. In comparison to the Bio-Rad HPLC Test for Adrenalin, Noradrenalin, Dopamine, Metanephrine and Normetanephrine they show well comparable results. Results corresponding with HPLC have only been found for Dopamine. Adrenalin and Noradrenalin show considerably lower results, therefore only level 2 results can be indicated. Experimental studies have shown antibody reactivities against both enantiomere forms of Adrenalin, Noradrenalin, Metanephrine and Normetanephrine being responsible for these differneces.