In its most extreme form someone does deliberately harmful and destructive acts rejecting any appeals to do what is for their own benefit never mind what is beneficial for others. They may claim that it makes no difference anyway since existence is pointless and therefore have no gratitude for the benefits they have in life. The contrast to this is someone who tries to improve himself, others and all of creation. They believe in God and are always grateful to Him for all they have in life. Their works to improve creation flow from their will to please God.
Human beings have the capacity to sin largely as a result of having the capacity to plan.
When someone plans their efforts, they need to be able to suppress their natural desires for a time. This is quite different from animals who live from moment to moment obeying their perceptions of the present and their instinctive drives. This is indeed a dramatic difference. Human beings are able to look to the future - conceptualise it and form an intention to act. This conscious intention can override even the most powerful of our instincts.