This was predominantly of mild and moderate entity. Intrauterine remission of borderline ventriculomegaly has been documented. However, it is debated is this implies or not an amelioration of the prognosis. It has also been proposed that the unilateral type is benign. However, in the original report of 30 cases some abnormal outcomes were reported, there was one fetus affected by trisomy 21 and one infant with seizures.
Limited data exist with regard to the association with chromosomal aberrations.
We believe therefore that at present it would be prudent to offer a procedure for fetal karyotyping. Infants with isolated borderline cerebral ventriculomegaly are at increased risk for developmental delay. It has been suggested that this finding could represent an indication for early childhood intervention, as special educational programs maximize the developmental potential. However, counseling these couples is a major undertaking. It has been our experience that the communication that the infant has even a slightly increased risk of cerebral damage or low intellect causes major distress to most couples.