Most studies were supported by a manufacturer. There was no information on side effect profile for either of these drugs. The authors conclude that glucosamine and chondroitin have some efficacy in treating OA symptoms. McAlindon TE, LaValley MP, Gulin JP, et al. Accessed March 17, 2000.
Antihistamines remain the cornerstone for the treatment of allergic rhinitis.
First-generation antihistamines are effective, but cause drowsiness and impairment in performing everyday tasks. Each participant received one dose of each of the study medications at weekly intervals, prior to driving for one hour in the driving simulator. Other measurements included lane-keeping and mean response time to blocking vehicles. Patients also self-reported drowsiness using a visual analog scale. Patients had significantly better coherence after taking alcohol, fexofenadine or placebo, compared to diphenhydramine.