What I really like about almost all options is the handy pop-up text that explains what a particular tweak does. General covers templates, boot options and system. In the first, you can define which file templates will be available when you right-click on the desktop. In System, you can change the Windows registration information. Configure whether you want a CD to auto run or not, and even cool down the CPU when it is not being used.
Internet gives the connection details including data transfer and total throughput.
I like the IE tweaks. You can fiddle around with the basic settings and also change the browser's title. Security lets you define what drives are visible and which dialogs can a user access. You can also disable the Registry Editor, DOS access and even Control Panel. You can also restrict access to the printer.