Contains 45 mg sodium chloride per 100 mg of cyclophosphamide. Reduce cyclophosphamide dose when using with other cytotoxic agents. Monitor blood, particularly neutrophil and platelet counts, regularly. Examine urine regularly for red cells that may precede hemorrhagic cystitis. Advise women of childbearing age to avoid pregnancy.
Drug is usually ineffective in acute blastic crisis of chronic granulocytic disease.
Contraindicated in patients with severely depressed bone marrow function. Contraindicated in patients who have shown previous hypersensitivity to cyclophosphamide. Drug treatment may not be indicated or should be interrupted or dose may need to be reduced in patients who have or who develop viral, bacterial, fungal, protozoan, or helminthic infections. In a few cases with use of high doses, severe, sometimes fatal congestive heart failure seen within a few day after first dose. Histopathologic examination primarily has shown hemorrhagic myocarditis.