Lefkowitz himself has divined the secret for success in science. He tells the story of a microscope he bought in medical school. It had been passed down through several generations of students and was showing its age. Lefkowitz would be studying his histology slides and he'd look away to his notes. When he looked back, the microscope would be slightly out of focus.
Every experiment suggests an infinite number of possibilities.
The magic is to see the path through, to see where there is a clear space. That's what I do. His attention is always focused on one question ahead of the game. He taught me how to think big. But the most important thing is that he helps people so eventually they won't need him.