It attempts to wed interests in molecular genetics with molecular evolution. Studies of the particular questions that can be addressed with advantage in each genetic model, and the special genetic approaches feasible in these respective systems, are emphasized. The course builds upon a strong prior background in Mendelian and molecular genetics. An advanced-level discussion of the organization and function of cytoplasmic organelles. Lectures and readings are from original research literature.
Emphasis is on the analysis and interpretation of experimental results.
The structure and function of formed elements in the nucleus are discussed. Emphasis is on understanding how knowledge in this field is acquired, rather than on a comprehensive treatment of all nuclear structures and functions. This understanding is obtained by analyzing original data, both in lectures and by independent reading of significant papers in the field. This course provides a broad overview of animal development, with emphasis on processes and underlying cellular and molecular mechanisms. Using examples from both vertebrate and invertebrate embryos, topics include fertilization, embryonic cleavage, gastrulation, early vertebrate morphogenesis, neural development, determination of fate by cytoplasmic specification and cell-cell interactions, mechanisms of gene regulation at transcriptional and posttranscriptional levels that mediate specific developmental processes, pattern formation, sex determination, and gametogenesis.