Many of the trials are nationwide. The nutrient supplement contains HMB, which may increase muscle mass and strength when combined with exercise. Participants will be divided into three groups, based on their response to protease inhibitors and their weight. Within each group, some will take the supplement 2x a day and the others will take a placebo twice a day. Neither the doctor nor the participant will know which treatment is being taken.
Clinic visits are once a week.
Body composition measurements and blood work, including viral load tests , will be done during the study.