Fox-Fordyce disease is an infrequently occurring chronic pruritic papular eruption that localizes to areas where apocrine glands are found.
Etiology is unknown at present.
The eponym is based on the 1902 report by G. Fox and J. Fordyce. Fox-Fordyce disease is a disease of skin alone. Shelly and Levy proposed apocrine miliaria as the cause in 1956. The observed pathophysiology is a keratin plug in the hair follicle infundibulum obstructing the apocrine acrosyringium and producing an apocrine anhidrosis. Histologically, there is a rupture of the apocrine excretory duct and a resulting spongiotic inflammation.