The relevance of physical activity for the kinetics of inhaled gaseous substances Gy.
Inhalation is the most important route of absorption for many volatile substances.
The inhaled chemical is distributed via the bloodstream into the organs and tissues. It is eliminated mainly unchanged by exhalation and also via metabolism. The blood concentration can be considered as a surrogate for the body burden of the chemical. It depends on the rate of uptake and on the rate of elimination. The latter is greatly influenced by physical activity, which thus has a crucial impact on the rate of uptake.