There was also a significant positive interaction between birth haemoglobin and iron intervention which multiplied the subsequent risk of admission. The effect appeared to be linear. Higher birth haemoglobin also incidentally was associated with more random malaria slide positivity at the six month visit in the placebo group. Whether this low birth haemoglobin protective effect was related to total body iron at birth or alpha thal genotype or both is an interesting question. This effect was non-linear, independent and with no interactions with haematological variables.
Iron supplementation increases prevalence and effects of malaria.
Report on clinical studies in Papua New Guinea. Effect of iron prophylaxis on morbidity due to infectious disease. Report on clinical studies in Papua New Guinea. The interaction of alpha thalassaemia with malaria. We have seen this recently in animal studies and in adult human clinical supplementation trials.