Use of Clinical presentation in children with HIV infection. A lot has changed over the last 3-4 years because of better drugs to treat HIV, but there is still a small subset of children who do not respond to treatment and who will progress in their disease. Nowadays these are more children who have virologic failure and not responding to treatment. But if you let the disease evolve naturally without any intervention, that s what you will see. They will develop AIDS within the first two years of life.
Anemia is common, neutropenia is another common non-specific finding.
But most frequent is thrombocytopenia. These children frequently have thrombocytopenia. Hypergammaglobulinemia is extremely frequent. You will do QIg s. The IgG levels will be extremely high, IgM as well, but if you do functional tests these antibodies are not working well.