No such fragile site was detected. A phenotypically normal male child was delivered. Follow-up analyses were conducted on peripheral blood from the child and a placental sample. Both revealed only normal male cells. The nature of the deleted chromosome 10 cell line is therefore still unclear.
Cultural artifact is unlikely, as it was detected in multiple chorionic villi cultures.
It is also possible that the chorionic villus biopsy sampled a region of the placenta with a population of abnormal cells. As no abnormal cells were found in the amniotic fluid, postnatal placental samples, or child's blood, it is possible that our findings represent confined placental mosaicism. If this was the case, the mosaicism had no apparent effect on the outcome of the pregnancy. We would appreciate information regarding similar experiences. A chorionic villi sample was obtained from a G3 P2 mother at 11 weeks gestation.