After age 50 Weakness of arms, legs and hands, especially thighs, wrists and fingers. Sometimes involves swallowing muscles. More common in men than women. Disease progression varies. Over 40 years Weakness and fatigue of hip muscles with aching back and thigh muscles common.
Lung tumor is often present.
Progression varies with success of drug therapy and treatment of any malignancy. Varies in severity, and weakness can fluctuate. Weakness and atrophy of muscles of hands and lower legs with foot deformities and some loss of sensation. Disease progression varies. 7 to 13 years Impairment of limb coordination, muscle weakness and loss of sensation.