Drug is indicated when treatment with an opioid analgesic is indicated for more than a few days.
Ingestion of broken, crushed, or chewed tablets leads to rapid release and absorption of a potentially lethal morphine dose. If signs of excessive opioid effects are seen early in dosing interval, reduce next dose. With experience, adjust dose to obtain an appropriate balance of pain relief, opioid side effects, and convenience of dosing schedule. Taper dosage gradually. Advise patients to report inadequate analgesia.