Morality should be based on compassion and reason. Natural events have natural causes. The universe is neither for us nor against us.
Human beings can figure out from experience what's right and wrong.
We human beings are responsible, to ourselves and to each other, to do what's right. To make it in this life, people need each other. Reason is the most powerful tool for solving human problems. Scientific method isn't perfect, and it isn't the only way of acquiring knowledge, but it seems to work better than any of the alternatives. Instead of expecting a god or the government to take care of human problems, it's better if people get to work on these problems themselves.