The findings of those studies provided direct evidence that iron is involved in cardiovascular disease etiology. The HH mutation is a human genetic model of disturbed iron metabolism, which facilitates research to the mechanism of HH and iron involved in cardiovascular disease. We expect that in the near future, the mechanism of disturbed iron metabolism leading to cardiovascular disease in human will be better understood. Randomized trial of estrogen plus progestin for secondary prevention of coronary heart disease in postmenopausal women. Heterozygosity for the hereditary hemochromatosis gene is associated with cardiovascular mortality in women.
Donation of blood is associated with reduced risk of myocardial infarction.
The Kuopio Ischaemic Heart Disease Risk Factor Study. Defective iron homeostasis in 2 -microglobulin knockout mice recapitulates hereditary hemochromatosis in man. Iron and the genetics of cardiovascular disease. The McGraw-Hill Companies. All rights reserved.