The goal of this work is to develop general methods for analyzing complex traits in experimental systems and learn about the particular disease models. These studies use a combination of expression assays for large numbers of genes, measurement of metabolite levels and enzyme activities in normal and variant mice with emphasis on folate metabolism and inositol phospholipid metabolism, and linkage analysis of genes controlling these traits as well as disease susceptibility genes. In addition we have identified anomalies in gene expression profiles in these mice and we have begun to define new networks of gene expression control. His laboratory is developing new kinds of mouse genetic resources for complex trait analysis. Finally, he has pioneered the mathematical analysis of comparative genetic maps as a means for studying genome organization and evolution.
Current work focuses on the evolution of gene families and physiological pathways.
Publications Nadeau, J. H. and B. A. Taylor, 1984. Lengths of chromosomal segments conserved since divergence of man and mouse. Genome Duplication and Comparative Gene Mapping. In Advanced Techniques in Chromosome Research . K. Adolph, ed.