The research in our group covers the fields of protein engineering, genomics, functional analysis of genes and gene products and automation. This includes combinatorial libraries using phage display and studies of in vitro and in vivo folding of recombinant proteins. The protein expression research also includes vaccine engineering, including bacterial surface display and faciltated purification of proteins using gene fusion technology. Integrated schemes for facilitated down stream processing are developed to create straight forward large-scale production. Laboratory work stations for integrated schemes in molecular biology, microbiology and biochemistry have also been developed.
Emphasis is put on large-scale DNA sequencing using robotics for liquid and magnetic handling.
A part of this group is involved in data analysis, data base handling and bioinformatics. Recent projects include analysis of the human properdin gene, a part of the yeast chromosome XV and sequencing of the total genome of the bacterium Mycoplasma mycoides. We also devlop brute-force methods for functional analysis of cDNA genes obtained in the human genome project. Protein engineering, protein folding and expression, vaccine engineering, combinatorial libraries, bacterial surface display, automation, robotics,DNA sequencing, genomics. Recent references Selected Abstracts Biosensor applications 163.