Meanwhile, Bolli's team continues to find out, at the basic studies level, what happens in the heart in the 24 hours from the time of the first ischemic stress to the second one. They've found that several molecules, protein kinases, tyrosine kinases, and a gene transcription factor called NF-KB, play roles in the preconditioning process. Bolli's current studies also suggest that different forms of nitric oxide, or nitric oxide sythases, play different roles in controlling different parts of the preconditioning response. Even with all these brand new findings, Bolli says only a fraction of the preconditioning process is known. I personally know that the more I do research the more I am bewildered by the complexity of nature.
Life is an incredible miracle.
It's mind-boggling how complex and incredibly intricate the biology of living organisms is. So, preconditioning, like everything else, is incredibly complex, and for us to really fully understand it it's going to require an extensive and presumably long-lasting endeavor that is going to span over several years, easily. CVD claimed 960,592 lives in the United States in 1995. This is 41.5 percent of all deaths or one of every 2.4 deaths. CVD claims more lives each year than the next seven leading causes of death combined.