Sarsaparilla was also used by the Chinese in the treatment of syphilis. Clinical observations in China demonstrated that sarsaparilla is effective, according to blood tests, in about 90 percent of acute cases and 50 percent of chronic cases. An interesting note is that sarsaparilla species have been used all over the world in many different cultures for the same conditions, namely gout, arthritis, fevers, digestive disorders, skin disease, and cancer. The mechanism of action of sarsaparilla is largely unknown, although the plant does contain several saponins and has been shown to be clinically effective in the treatment of psoriasis. This evidence points to a possible effect on binding of cholesterol and bacterial toxins in the intestines.
Evidence seems to support sarsaparilla as an endotoxin binder.
Endotoxins are cell wall constituents of bacteria that are absorbed from the gut. Normally, the liver filters out these and other gut-derived compounds before they reach the general circulation. If the amount of endotoxin absorbed is excessive or if the liver is not functioning adequately, the liver can become overwhelmed, and endotoxins will spill into the blood. Smilax is another herb with a reputation as a remarkable tonic and male rejuvenator. This herb has been receiving considerable attention lately, but not of a research nature.