Clinical history and physical exam along with the laboratory abnormalities provide clues to the diagnosis. Endoscopy with biopsy usually clinches the diagnosis. Sulfasalazine is the prototype aminosalicylate and newer 5-ASA preparations like Asacol, Pentasa, Dipentum are available. In addition, ASA may be administered as rectal suppositories and enemas. Corticosteroids may be given as intravenously, by mouth or as rectal enemas.
Corticosteroids have substantial long-term toxicity.
Acute Sulfasalazine Overdose. Journal of Toxicology Clinical Toxicolgy 1991. Minocha et al. Small Bowel Endometriosis Masquerading as Regional Enteritis. Digestive Diseases and Sciences 1994.