The pharmacokinetic profile of rimantadine in children has not been established. In some children drug was detected in plasma 72 hours after the last dose. Three hydroxylated metabolites have been found in plasma. Studies of the effects of renal insufficiency on the pharmacokinetics of rimantadine have given inconsistent results. Hemodialysis did not contribute to the clearance of rimantadine.
Albumin is the major binding protein.