The most common adverse reaction reported with erythromycin topical gel was burning. Irritation of the eyes and tenderness of the skin have also been reported with topical use of erythromycin. A generalized urticarial reaction, possibly related to the use of erythromycin, which required systemic steroid therapy has been reported. The hands should be washed after application. If there has been no improvement after 6 to 8 weeks, or if the condition becomes worse, treatment should be discontinued, and the physician should be consulted.
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