Acute chorioamnionitis represents an ascending infection from the birth canal, usually accompanying premature rupture of the membranes. Premature labor, prematurity, fetal infection. These slides are from 2 separate cases. In each case, the pancreas was firm with accentuation of the lobular pattern. A small amount of extramedullary hematopoiesis occupies the interstitial connective tissue.
Islets are abundant, preserved, and uninvolved.
Most of the tissue consists of dilated ducts filled with inspissated secretion and surrounded by bland connective tissue. Islets are unaffected and lie within the connective tissue. In each case, the features represent inspissation of secretion within pancreatic acini followed by progressive destruction of the pancreatic parenchyma and replacement by fibrous connective tissue. Pushing the kidney caudally, a large, fairly well defined tumor replaced the left adrenal, extending medially across the midline. On cut section, an ill-defined lobular pattern was interrupted by focal areas of fresh hemorrhage and calcification.