Test code links throughout this Guide refer to the corresponding test in the User's Guide. A streptococci produce significant quantities of DNase-B, while most other groups of streptococci do not. High levels of neutralizing antibody to DNase-B are commonly found in patients following a group A streptococcal infection.
Elevated titers are strongly suggestive of recent or current infection with group A streptococci.
Fourfold increases in titer between acute and convalescent samples taken approximately 2 weeks apart are confirmatory. In Manual of clinical laboratory immunology , 4th ed. NR Rose, et al, eds. Gerber MA, et al.