The recovery period usually is prolonged. While SSSS occurs predominantly in children, TEN affects more adults more than children. The prognosis in geriatric patients is unfavorable. In addition to characterizing the physical, constitutional, and mucocutaneous symptoms, a detailed history should focus on known etiologies of TEN, such as medication or chemical agent use, maternal-fetal transfusion, blood product administration, recent infections, measles immunization, or recent radiotherapy. Prodromal symptoms may precede skin lesions by 1-2 weeks.
Fever is the most common symptom.
Upper respiratory infection like symptoms, such as malaise, anorexia, headache, sore throat, cough, nausea, vomiting, and diarrhea, are present. The skin is diffuse, erythematous, and painful, and tender skin lesions are present. The scalp usually is spared. Mucous membranes have painful inflammation and blisters on the mucosal surfaces, especially the oropharynx. These symptoms may limit oral intake.