There was no evidence of granulomatous inflammation or of metastatic tumor. A bone marrow biopsy demonstrated focal involvement. Immunostaining was positive for CD20 and CD79a, findings confirmed by flow cytometry with CD10 positivity also observed. In situ hybridization for EBV was positive in numerous cells. Non-Hodgkin's lymphoma, consistent with Burkitt's lymphoma.
Incidence varies according to the type and extent of immunosuppressive therapy.
PT-LPDs may develop quickly in multiple sites and represent clonally distinct tumors. References Knowles, D.M. Immunodeficiency-associated lymphoproliferative disorders. Natkunam, Y. et al.