Tests to determine how well the drug is working should be taken periodically and the medication changed if the mycobacterial infection develops resistance to a particular drug. Patients on multiple drug regimens may find it difficult to take many different drugs consistently over a period of many months, but compliance with TB treatment is very, very important. The primary side effect of pyrazinamide is liver damage, usually a result of taking the drug over a prolonged period of time. Other toxicities include rash, kidney dysfunction, and in rare cases eye inflammation.
Liver toxicity is by far the most serious and common side effect.
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