B. A major therapeutic thrust has been the use of creatine monohydrate in neuromuscular and neurometabolic diseases. We have continued to characterize the potential mechanisms for sex differences in metabolism at the cellular and whole body level. We have studied sex differences in muscle damage and are characterizing the steps involved in muscle damage. A randomized, controlled trial of creatine monohydrate in patients with mitochondrial cytopathies. Postexercise protein-carbohydrate and carbohydrate supplements increase muscle glycogen in men and women.
Creatine monohydrate increases strength in patients with neuromuscular disease.