In addition, we are at the cutting edge of translating these diverse sets of data into risk assessment models. This strategy is providing a clearer picture of the amount of exposure required for adverse health effects. These agents are evaluated for carcinogenic activity, effects on male and female reproduction, neurologic effects, effects on the immune system and effects on the fetus and newborn. Studies are being conducted on the production of sperm and eggs, the estrous cycle, the ability to conceive and maintain pregnancy, and on the induction of malformations of the reproductive organs. Particular emphasis is given to delayed and long-term effects.
Investigations are also underway to develop and validate biomarkers of estrogen and dioxin exposure.
Such biological indicators are designed to provide early evidence of exposure to estrogenic and dioxin-like chemicals and to indicate the potential for adverse effects for a given exposure level. These studies are helping us to more rapidly determine if an agent is linked to an adverse health effect. A combination of in vitro and in vivo assays is being developed and evaluated with the purpose of providing a rapid, informative, and reproducible means by which to determine the estrogenicity or dioxin-like potency of environmental chemicals. These studies will help determine which agents in the environment possess endocrine disrupting potential. These studies integrate basic research toxicology, epidemiology and biomethematics.