These feelings tend to last 3-6 hours. As the drug kicks in, users may experience an initial rush of nervousness, and uncertainty, a tightening of the jaw, increase heart rate, sweating, and nausea. This is sometimes known as 'coming up'. Some users have reported a bad experience on ecstasy, including feelings of paranoia and confusion. Much depends on the content of the drug and the user's state of mind at the time.
Ecstasy effects the body's thermostat.
Taking ecstasy may leave women susceptible to cystitis and thrush. Men report difficulties in attaining an erection or orgasm while on ecstasy. After the effects have subsided, users can feel tired and depressed for days. There is some debate into to the long term psychological effects of ecstasy use, including links to possible brain damage. It is illegal to reproduce, supply, or possess the drug.