Infection is a major problem for people who get liver transplants. Infections with fungus are a particularly big problem.
Fungal infections can be hard to treat and potentially deadly.
It may make sense to try to prevent them from happening in the first place. The researchers wanted to see if giving liver transplant patients an antifungal medication called fluconazole could prevent them from getting fungal infections. They also wanted to make sure that using fluconazole this way would be safe for patients and would not cause damage to the new liver. 212 patients who had a liver transplant at a transplant center in Los Angeles, California. Study patients had to be free of fungal infection at the start of the study.