Four years after onset the neuropathy has improved but vision has deteriorated. Other organs have not been affected. Light chain deposition disease is rare and the combination of demyelinating neuropathy and corneal deposits has not been reported previously. The exact mechanism of corneal deposition is unknown, but paraprotein has been documented in tear film and aqueous humor. Differences in target tissue binding between ocular tissues and peripheral nerve myelin may have influenced the differences in treatment response.
Effective treatment remains difficult.