Any deficiencies of these nutrients will affect the conversion. GLA is part of the Omega 6 series of essential fatty acids and is the critical precursor to the series 1 prostaglandins and other hormones in the body. The PGE1 series prostaglandins along with the PGE3 series protect the body against the deleterious effects of PGE2 series prostaglandins, such as high blood pressure, sticky platelets, inflammation, water retention, and lowered immune function. The series 2 prostaglandins are made from arachidonic acid which is derived from consumption of excess animal products. No known toxicity associated with Evening Primrose Oil.
Excess consumption can result in oily skin, an indication to decrease dosage.