This service allows EHS Center members in each Research Core and research focus group a unique opportunity to elucidate the molecular and cellular mechanisms of gene regulation in vivo in a whole animal, and to define the role of interaction between genetic determinants and environmental exposures in the pathogenesis of a variety of human diseases.
Investigators can also receive hands-on training on animal handling, genotyping, and breeding.
Since a thorough study on a new model of transgenic mice often requires a variety of research expertise, this greatly facilitates collaboration among Center members as well as initiates new research direction and opportunity. The service provided is also available to other Non-Center members in the University community at a fee and with less priority. The Core has two microinjection stations and other supporting instruments for performing the services provided. The Core consists of two animal rooms that house various stock mice required for the production of transgenic mice and one surgical suite. Two microinjection stations are located in the surgical suite for microinjection of fertilized mouse eggs for making transgenic mice and of blastocysts for generation of gene knockout mice.