Sixteen nodules were inadequately sampled with both needles. Eight of these were less than 1 cm in greatest dimension. No significant complications were encountered. Needles of both 23 and 27 gauge can be used to obtain fine-needle aspiration biopsy samples from thyroid nodules. Using both sizes is recommended, because the number of dry passes is lower with the larger needle, but the diagnostic quality of the aspirate may be better with the smaller one.
Experienced physicians can perform fine-needle aspiration biopsy with equal proficiency.