Removal of protein granules from milk by phagocytic digestion occurs in the vacuoles. The gland is penetrated by adipose tissue. Plasma cells, lymphocytes and neutrophils increase in number during involution, but the leukocyte response is limited unless an inflammation occurs due to disease. When involuted, the gland resembles that of the virgin animal except that the duct system is more extensive. F. Biochemical Changes Occurring During Involution 1 .
Epithelial cells lose the ability to incorporate fatty acids, acetate, and glucose into lipids.
A reduction in the oxidation of glucose occurs. A gradual loss of function of the mitochondria occurs. An accumulation of fatty acids and oleic acid occurs in the epithelial cells. G. Retardation of the Involution Process 1 . Continued milking or suckling retards involution.