Major depression is also a mood disorder.
In its extreme form, someone in a manic episode can completely lose touch with reality. Usually, a person has one or at most two mood swings in a year. Both manic and hypomanic episodes can be triggered in susceptible individuals by the use of antidepressants , including the nutritional supplement SAM-e . There is some evidence that women are more prone to bipolar II disorder than men are, and five to fifteen percent of people who start as bipolar II can progress to bipolar I disorder. The disturbance has to last for at least two years.