Even an organic insecticide can't distinguish between bad bugs and good bugs, such as honeybees. However, sometimes plants need to be protected from harmful insects.
Honeybees are most active during warm, sunny hours.
If you apply insecticides at night while they're resting in their hives, they won't be hit by the dust or spray. Many of the nasty plant-munching critters, on the other hand, do their dirty work at night. By applying the insecticide while they're active, you can focus on your target insects. It's still wise to use as few pesticides as possible. But treating at night is the best time for bees.