3 Ansell et al. and Bhawan et al. were the first to demonstrate that the neoplastic intraluminal cells are of lymphoid origin of B-cell lineage. 8,9 Otrakji et al. This study provided the first genotypic evidence for the monoclonal proliferation of B-cells in this condition. They also demonstrated strong positive reaction with anti-Kappa light chain antibody in cryostat cut fresh frozen section. 7 Figure 2.
Liver biopsy shows plugging of sinusoids in large mononuclear cells.
Immunohistochemical stain on the mononuclear cells stain for L-26. 2,10 Histopathologic diagnosis of IVL on biopsy material is usually problematic, since many pathologists are still not aware of this entity. Most of the reported cases in the literature have been diagnosed at autopsy. A review of bone marrow biopsy showed similar involvement. This is the first case of IVL reported in Saudi Arabia, and we believe that increased awareness of this type of lymphoma will result in recognition of additional cases.