Topical creams are typically applied twice daily to the affected areas. Systemic therapy is rarely required for tinea pedis, except in rare disabling cases. Treatment of dermatophytes should include maintenance of a dry environment, as the infection thrives with moisture. Cotton wisps may be placed between the toes to further increase aeration. The topical imidazoles, such as clotrimazole, econazole, ketoconazole, miconazole, oxiconazole, and sulconazole, are highly effective against a wide range of fungi, including dermatophytes as well as Candida species.
Imidazoles impair the biosynthesis of ergosterol for the cytoplasmic membrane of fungi.