MO, March, 1992. Nasalide nasal solution package insert. Palo Alto, CA, July, 1988. Azmacort oral inhaler package insert. Collegeville, PA, June, 1993.
Corticosteroids are potent anti-inflammatory agents used in the management of asthma.
Glucocorticoids act on mast cells by slowing the synthesis of histamines. The benefits of inhaled corticosteroids include a reduction in airway inflammation, a decrease in mucus secretion and airway edema, and a reduction in airway hyper-responsiveness. Again the Expert Panel has deemed that chance for adverse effects is far outweighed by the benefit. Inhalation therapy allows the topical administration of potent anti-inflammatory agents directly at the site of action in the airways. Administration directly to the site of action helps decrease the adverse effects observed with systemic corticosteroid therapy.