The most common abnormality in PBC is the alklaine phosphatase. This is an enzyme found on the outside of liver cells. Its degree of elevation does not correlate with the extent of liver damage seen on liver biopsy. In early disease, these may be the first tests that are abnormal. The platelet count is generally normal in PBC until more advanced liver disease occurs.
Low platelets are a sign of portal hypertension and possible cirrhosis.
This is a very valuable test used by doctors to determine extent of disease. An elevated bilirubin is of concern and should prompt an immediate evaluation. In general, bilirubin levels do not fluctuate in PBC unless treatment is initiated. When a doctor notes an elevated bilirubin in PBC, it should warrant concern and furhter consulation with the patient. Its titer does not correlate with extent of disease.