Test code links throughout this Guide refer to the corresponding test in the User's Guide. This remark is supported by the fact that totally pancreatectomized patients present zero TLI levels, but detectable alpha-amylase levels. TLI is consistently elevated in acute pancreatitis and in chronic renal failure. In chronic pancreatitis, levels are decreased in patients with steatorrhea, but may be elevated in those with acute relapses.
Levels are variable in pancreatic carcinoma.
Elevated levels of TLI have also been reported in infants with cystic fibrosis and may be used in screening programs for this disease. The assayable species by this method has been shown to be cathodic trypsinogen. The expression of analytical data as trypsin-equivalent concentration is used by most laboratories. Hammond KB, et al. Efficacy of statewide neonatal screening for cystic fibrosis by assay of trypsinogen concentrations.