His compound was a pandora's box of ugly things just waiting to happen. The bottom falls out of Jacob's life. He lost the two relationships that mattered most to him. His favourite wife and his favourite son. Jacob is at the end of his rope.
Life can be hard, painful and unforgiving.
Often the pain is our fault or the cruelty of others, or the result of natural phenomena like floods, earthquakes and storms. Sour relationships cause me the greatest stress. Joseph has lost his family and it looks like his future is spoiled.