Avoid use in patients with depressive neurosis or psychotic reactions as paradoxical effects may occur.
Excessive sedation associated with zopiclone is likely to impair motor function.
Patients should avoid operating machinery or engaging in other hazardous activities that require mental alertness and motor coordination. Use with caution in the elderly as zopiclone may worsen cognitive functions and cause mental confusion. Avoid abrupt discontinuation after prolonged use, as it may precipitate withdrawal symptoms. Dosage adjustments may be required in patients with impaired liver function.