In rare instances, allergic reactions in the form of a temporary skin rash have occurred in sensitive individuals. The manufacturing procedures for the control of the production of PCO from grape seeds must comply with international standards of quality and safety. Independent laboratory tests ensure freedom from pesticides, solvents, or chemical residues. Then the amount may be reduced to as little as one-half that amount. This reduced dosage would be for general protection, not for specific health problems, which may require higher doses.
Effective dosage varies with the severity of the condition.
It is always wise to consult a knowledgeable practitioner on dosage for specific conditions. As an example, allergies may require 100 to 200 mg, two to three times per day for a few days until the body builds up a sufficient quantity to stabilize the condition. As an adjunct to cancer therapy, 150-200 mg, four times per day might be taken to enhance immune response. As previously stated, dosages far greater than that have been shown to have no toxic effects. It has many refs from French and Italian journals, with many of them being authored by Jacques Masquelier, since he is said to be the original discoverer of OPC's from peanut skins and the major contributor to the current scientific understanding of grape seed and pine bark OPCs.