No information is available on retinoic acid binding during the menstrual cycle. Another example is valproate. Psychiatrists currently use more of the anticonvulsant valproate than do neurologists, for the treatment of bipolar disorder. Some studies have suggested that the rate of polycystic ovary syndrome and associated endocrine abnormalities may be related to long-term exposure to valproate in women, and further investigations are being done. Preliminary evidence with antidepressants and antihypertensives shows an induction of hepatic enzymes during pregnancy which necessitates greater oral dosage to maintain adequate serum levels.
Little information is available about medication use during breastfeeding.
We have developed a strong, interactive research program in breast cancer at Case Western Reserve University and its affiliate hospitals, University Hospitals of Cleveland and Metropolitan General Hospital. The Center represents a comprehensive cancer treatment and research program based on a synergistic interdisciplinary integration of the scientific, clinical and organizational expertise. Physicians and scientists from the Departments of Surgery, Medicine, Radiology, Pathology, Pharmacology, Molecular Biology, Genetics and Biochemistry collaborate in the Clinical Research Center. The scientific goals are the development of molecular markers and therapy for breast cancers and understanding the signals for oncogenesis and death in breast cancer cells. Another project focuses on the mechanism of programmed cell death of breast cancers with potential to develop therapeutic agents.