Smoking cigarettes can affect how quickly your body uses Clozaril. Weight gain, especially in children. Decreases action of L-Dopa. Interacts with carbamazepine and clozapine. May potentiate, or be potentiated by, SSRIs.
Lowers seizure threshold.
Potentiated to a high degree by phenytoin. May interfere with the effects of drugs for high blood pressure. May be potentiated by other drugs, including ketoconazole, erythromycin, clarithromycin, diltiazam, verapamil, and nefazodone. People with liver or kidney problems, heart disease, thyroid problems, or low blood pressure should be monitored while taking Seroquel. Drowsiness, dizziness, nausea, lightheadedness.