Intracellular signals induced by LPA include the production of free radicals and alterations in mitochondrial function. The focus of the studies in this laboratory is on understanding the roles of LPA and related lipid biomediators in both normal and pathological processes in the brain. The combined studies should result in a comprehensive portrait of the functions of LPA in normal and pathological processes in the brain. Moreover, these studies should identify potential therapeutic targets for modification of LPA-mediated effects in acute and chronic brain injury. Lysophosphatidic acid induces a sustained elevation of neuronal intracellular calcium.
Lysophosphatidic acid induces necrosis and apoptosis in hippocampal neurons.
Lysophosphatidic acid and apoptosis of nerve growth factor-differentiated PC12 cells. Lysophosphatidic acid induction of neuronal apoptosis and necrosis. N. Y. Acad.