Patients of Hispanic origin are well represented in the Silverman-Handmaker variety. As for diseases with fatal outcome. Other findings may include cephalocele, mid-facial defects, cleft palate, cardiac defects, and hydronephrosis.
Inheritance is probably autosomal reces sive.
Patients of Hispanic origin seem to be heavily represent ed in the Silverman-Handmaker variety of the disease. At our institution we have recently diagnosed and delivered another patient with the Silverman- Handmaker type of dyssegmental dysplasia. She presented to the antenatal testing unit at our institution at seventeen weeks estima ted gestational age. She was a referral from her primary care physician for evaluation of intrauterine growth retardation. Note the haphazard arrangement of the vertebral bodies in the lumbar region.