Prevention of renal calculi composed of uric acid or cystine. Inhibits renal carbonic anhydrase, producing self-limited excretion of sodium, potassium, bicarbonate, and water Inhibits CNS carbonic anhydrase, which may decrease abnormal neuronal firing. Lowering of intraocular pressure Control of some refractory seizures Prevention and treatment of acute altitude sickness Prevention of uric acid or cystine renal calculi. Well absorbed following oral administration.
IV administration results in complete bioavailability.
Excretion of barbiturates , aspirin , and lithium is decreased and may lead to decreased effectiveness Excretion of amphetamine , quinidine , procainamide , and possibly tricyclic antidepressants is decreased and may lead to toxicity. Assess for allergy to sulfonamides. Assess for eye discomfort or decrease in visual acuity. Monitor neurologic status in patients receiving acetazolamide for seizures. Initiate seizure precautions.