Background on Folate Metabolism Background on Folate and B12 Metabolism .
Folic acid is a carrier of one-carbon fragments which it transfers to various biochemical targets.
At the end, the individual reactions are tied together to show the major reactions involving one-carbon transfer. Click here to see the overall reaction first . One of the obvious consequences of this deficiency is megaloblastic anemia, that is, a deficit in the generation of mature red blood cells. The transfer includes the CH2 group plus a hydrogen from the cofactor itself, that is, the cofactor is effectively oxidized in the process. This means DHF must be re-reduced to THF 2.