LaDuke founded the White Earth Land Recovery Project. The project works on restoring land base and regaining lands promised to the Anishinaabeg in a federal treaty issued in 1867. More than 90 percent of the 837,000 acres of land is controlled by non-Anishinaabeg. Nationally, LaDuke is the program director for Honor the Earth Fund. LaDuke is also the co-chairwoman for the Indigenous Women's Network.
Environmental issues guide the network, which is composed of Aboriginal women in Saskatchewan.
Together these women address issues that affect the survival of Aboriginal people such as uranium mining, clear cutting and damming of rivers. In 1994, Time Magazine named LaDuke as one of America's 50 most promising leaders under the age of 40.