Studies indicate that renal blood flow and glomerular filtration rates are significantly decreased. Tight clothing such as belts and girdles increase intra-abdominal pressure and should be avoided. Some fatal liver inflammations have been linked to Depakene. The researches feel that Depakene should not be prescribed for children unless other measures fail. Actifed was particularly mentioned.
Hallucinations indicate an unwanted influence on the brain.
Studies have shown that applying it to the ear produces unwanted side-effects. Now a report of loss of hearing due to oral administration of chloramphenicol is reported in a 20 year old girl. She suffered diminished hearing in both ears, and follow-up for ten months showed the loss to be apparently permanent. A Japanese study reveals that rice bran may be effective in the prevention of recurrent kidney stone disease. High levels of calcium in the urine are associated with a high incidence of kidney stones.