They eat insects, rodents, mice, frogs, crayfish, small birds, and eggs. They will raid garbage cans, eat table scraps and commercial cat food if given an opportunity. They will enter hen houses for eggs. They will uproot crops in gardens while hunting insects. Some evidence suggests that spotted skunks resist rattlesnake venom and will eat the snakes.
Few animals eat spotted skunks except great horned owls and a host of tiny parasites.
Some people kill spotted skunks because they think they are a nuisance or they trap them for their low priced pelts. If your dog is so dumb that it just can't leave the skunk and its white target alone, don't kill it. The skunk, that is. Drive pesky skunks away by sealing up entrances to potential dens. If they have already taken up residence they can be discouraged by training flood lights in the den area.