Evidence exists for the modulation of sympathetic neurotransmission by endothelial cell mediators.
Moreover, administration of a novel SOD mimetic to these animals results in a greater amount of NE and Epi in the plasma and a corresponding reduction in the levels of adrenochromes. These plasma measurements correlate with a reversal in the hypotension. For instance they are known to inhibit the production of pro-inflammatory cytokines. Thus, we are currently further examining to what extent the deactivation of CA contributes to the pathogenesis and ultimately the morbidity of this multi-factorial inflammatory disease. T.C. A new perspective on the inhibitory role of nitric oxide in sympathetic neurotransmission.