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Studies in vitro have shown that vitamin D3 is immunosuppressive or immunomodulating and studies in exptl. Questions focused on perinatal events and early eating habits including vitamin D supplementation. Vitamin D supplementation was assocd. This large multicenter trial covering many different European settings consistently showed a protective effect of vitamin D supplementation in infancy. The findings indicate that activated vitamin D might contribute to immune modulation and thereby protect or arrest an ongoing immune process initiated in susceptible people by early environmental exposures.