If on the west side, Century City makes a good hub and offers a range of hotels. There is the plush Century Plaza Hotel Tower on Avenue of the Stars. The nearby Century City Inn Suites is less than half the price.
Downtown hotels cater to travelers attending the convention center.
Wyndhams Checkers Hotel is a favorite with young business people, the Biltmore is more traditional, the New Otani attracts Asian business travelers, and there are plenty of inexpensive choices such as Holiday Inn . You might also consider staying near LAX . Unlike many large cities, Los Angeles' airport is quite close to the city and is located on the shore. There are dozens of hotels and motels in the area, many providing bus service to both downtown and the airport terminals. Century Plaza and Doubletree Hotel are two.