Driving Botswana, along with the rest of the region, drives on the left. The main roads are well-maintained. There are however problems of safety. Speeds are high, and as the main road between Gaborone and Francistown has only one lane in each direction, a lot of overtaking takes place, not necessarily in sensible circumstances. In the south of the country the animals are livestock - cattle, goats and donkeys.
Donkeys seem to have especially little road sense.
In the far north, wild animals are common. In particular, on the road to Kasane elephants are common. Elephants are highly intelligent and not normally aggressive, but should be treated with respect. If there is an elephant in the way, wait for it to move well off the road. On the main road, there is a cleared strip either side of the road which enables you to see animals before they jump in front of you.