Reviewing and understanding PLS chemical compatibility guide will assist in making the best choice. It has excellent chemical compatibility for aqueous and aggressive organic solvents, is hydrophilic, and is useful when selection is difficult for complex sample matrices. Extractable materials may jeopardize analytical results. For chromatographic analysis, scenarios resulting from extractable materials include sample absorption, coelution, and extraneous peaks. Anomalous results are an analyst's nightmare as procedures typically require action to remedy or identify spurious findings.
Extractable materials become even more of a concern as the amount of analyte diminishes.
With these improvements comes increasing concern for the effects of extractable materials. Top How to avoid extractables' detritus effects. There are three primary methods to avoid the detritus effects of extractable materials. When excess sample fluid is available, discard the first few milliliters of fluid eluting from the syringe tip device. Generally, the amount of extractable materials eluted tapers with the volume passed.