Elevation throughout the brain areas suggests a generalized brain abnormality. Alterations in membrane phospholipid metabolism could alter membrane composition and fluidity and lead to neuronal death. It cannot currently be determined, however, if these changes precede the neuronal cell death or are a result of the cell death. Diagnosis depends upon differentiation of OPCA from other cerebellar ataxia s. Criteria for diagnosis include the relatively late onset, absence of spinal cord disease, family history, symptoms presented, and the progressive nature of the disease.
Current interventions are limited to treating the symptomology.
Patients may be taught direct strategies to improve swallowing and prevent aspiration pneumonia, and may receive physical therapy to aid in coordination of movements. Kish, Stephen J. et. Brain Choline Acetyltransferase Reduction in Dominantly Inherited Olivopontocerebellar Atrophy . Kish, Stephen J. et. Kish, Stephen J. et.