Hemodialysis does not alter the half-life of doxycycline. Doxycycline pharmacokinetics have not been evaluated in patients with hepatic insufficiency. Both treatment groups were administered a course of scaling and root planing in 2 quadrants at Baseline. The results are summarized in the following table. Enamel hypoplasia has also been reported.
All tetracyclines form a stable calcium complex in any bone forming tissue.
This reaction was shown to be reversible when the drug was discontinued. Doxycycline can cause fetal harm when administered to a pregnant woman. Evidence of embryotoxicity has also been noted in animals treated early in pregnancy. If any tetracyclines are used during pregnancy, or if the patient becomes pregnant while taking this drug, the patient should be apprised of the potential hazard to the fetus. Studies to date indicate that this does not occur with the use of doxycycline in patients with impaired renal function.