Not as much as previously thought.
Examples are linoleic acid and alpha-linoleic acid.
Our bodies use some of these derivatives to make prostaglandins, which have hormone-like regulating and communicating functions in our cells. These are extremely important to our health. The dietary balance of these two types of PUFAs is the important thing and is not related to cholesterol consumption in the diet. They also neither raise nor lower blood cholesterol. An excess of MUFAs will raise blood triglycerides which increase cardiovascular risk.