The solvent reacts with natural adrenaline-like substances to cause heart failure. This is more likely to occur during strenuous exercise or if suddenly frightened immediately after or during sniffing. Sudden death from solvents can also be caused by lack of oxygen if a plastic bag is placed over the head or from suffocation is aerosols are sprayed directly into throat from swelling and spasm of the larynx. Accidents Accidents such as drowning and injury from motor vehicles occur in much the same way as intoxication from alcohol. Use of solvents as a coping mechanism may replace other, more functional coping strategies.
Impulse suicide is more common during periods of intoxication.
Young males are the highest users of solvents and also amongst the highest risk groups for suicide. Some people can become dependent upon solvents, which may cause serious disruption to their lives as well as resulting in developmental delays. Some young people use solvents to manage psychological pain and as a way to show others they have problems. It's use may be similar to self-harming behaviours. Suicide is a high risk with these young people, particularly in unsupported detoxification.