Kinins can also affect nerve endings and create pain. They are also needed for the cells under attack, because their metabolism rapidly increases. During inflammation, toxic proteinaceous material is released which can foster disease unless it is removed. Neutrophils release proteolytic enzymes when they arrive at the scene, to solubilize this material and prevent infection. Topical solutions of proteolytic enzymes have been utilized to decrease inflammation and increase healing.
Calcium helps transport essential minerals to the site of inflammation.
After periods of trauma, the system tends to be alkaline, and it is important for an acid-calcium to deliver healing nutrients to binding sites. Magnesium increases the solubility and retention of calcium. Magnesium gets depleted in conditions of inflammation, and is integral to the healing process. Repletion of manganese after inflammatory trauma is necessary to keep up the free radical defense system. Manganese also functions in protein metabolism, essential for rebuilding after injury.