There are thought to be 6 genes within this molecule. Because it is an RNA virus, it must undergo cytoplasmic replication and is released by budding from the plasma membrane of the infected cell. It is susceptible to UV light, heat and drying, the virus is considered somewhat candy-ass , although it can withstand near freezing temperatures for weeks. Pathogenesis During natural exposure, CDV spreads by aerosol droplets and comes into contact with the epithelium lining the upper respiratory tract. Within 24 hours, it multiplies in tissue macrophages and spreads in these cells via local lymphatics to tonsils and lymph nodes.
Further spread depends on the dog s humoral and cell mediated immune status.
Canine distemper has a very high morbidity and mortality in populations of infected dogs. It is spread by aerosol or droplet exposure. As was mentioned above, it is highly contagious, and can lead to peracute or acute febrile disease. The peracute form of the disease is characterized by sudden fever and death within days. Gastrointestinal disease results in severe vomiting and watery diarrhea.