Salicylate metabolism occurs primarily by hepatic microsomal enzymes. These metabolic pathways are saturable and clearance decreases with increased serum concentrations. The half-life of the parent drug is about 20 minutes while the active salicylate can range from 3 to 10 hours depending upon the dose. Dipyridamole is metabolized by glucuronidation and concentrated mainly in the liver. The monoglucuronide metabolite has little activity.
Elimination occurs in the feces via bile as glucuronide conjugates and unchanged drug.
Patients should take the medication with food or milk to help minimize upset stomach, diarrhea, and GI discomfort. Patients should seek medical attention if ringing in ears or persistent GI pain occurs. Patients should ask a doctor or pharmacist before taking any over the counter medications. Patients should not take any products containing aspirin or warfarin without notifying their physician or pharmacist. Inc. Ridgefield, CT, December, 1999.