Certain regimens can be used to reduce this. Some concern over estrogen's potential for induction of uterine cancer exist. As long as a progestin is used in conjunction with the estrogen, this risk is eliminated. Fear of breast cancer discourages many prospective estrogen users. Fosamax is a pill and has to be taken 30 minutes prior to anything else in the morning.
Gastric irritation causes some people problems.
Miacalcin is a nasal spray and can be taken at any time of the day. Nasal irritation is the main side effect that might be noted. Either one can be used in conjunction with estrogen. All ladies who are menopausal should take calcium supplements. Daily doses should be 1000 mg and can be obtained from many sources.