This has greatly advanced the speed and automation of sequencing. The specific binding pattern can be read by a computer, and the sequence determined. The development of DNA chips has allowed for sequencing at 100 times the rate of previous systems. Micro-capillary electrophoresis techniques help speed the process and reduce costs. Less materials are consumed.
Less sample is needed.
This technology will have application long after the genome project. Radiation Hybrid Mapping is used in conjunction with STS sign-posts and PCR assay. Each cell line has a random set of human DNA fragments formed after irradiation of genomic DNA in a hamster cell. Calculations identify the continuous linkage along each arm of a chromosome. The markers are assembled into the map as a single linkage group.