In simpler terms, it takes more energy to fill the heart than to empty it. Diastolic dysfunction is a stiffening of the heart muscle which interferes with the heart's ability to function as an effective pump. It is seen early in the course of many common cardiac disorders and is demonstrable by echocardiography. This stiffening returns towards normal with supplemental CoQ10 in tempo with clinical improvement. It is important to note that in all of the above clinical trials, CoQ10 was used in addition to traditional medical treatments, not to their exclusion.
Hypertension is reduced when diastolic function improves.
Facts and perspectives on CoenzymeQ10 in biology and medicine. Casa Editrice Scientifica Internazionale, pp 1-91. 2. Quinones and quinols as inhibitors of lipid peroxidation. The inhibition of mitochondrial peroxidation by ubiquinone and ubiquinol. Deficiency of Coenzyme Q10 in human heart disease.