Free registration is required.
When administered by gavage TCDD increased the incidences of thyroid follicular cell adenomas in male rats and neoplastic nodules of the liver in female rats. When administered by the same route TCDD increased the incidences of hepatocellular carcinomas in mice of both sexes and thyroid follicular cell adenomas in female mice. When administered in the diet the compound induced hepatocellular carcinomas and squamous cell carcinomas of the lung and hard palate nasal turbinates in female rats. When administered topically TCDD induced fibrosarcomas of the integumentary system of female mice. When administered by intraperitoneal injection TCDD induced thymic lymphomas and liver tumors in infant mice.