With proper handloads, the .44 Spl. smacks a swinging steel plate with authority at 50 yards. Yet, it should be sufficiently mild mannered to fire several hundred rounds without the fatigue that comes from heavy recoil. 29 Classic and Mod. 629 Mountain Gun is superb. And, of course, there's the economy of shooting cast lead bullets.
Jacketed bullets are pricey, and a total overkill for plinking.
Only 180 gr. jacketed bullet loads are offered by the major ammo companies. For self defense, cost is not a factor. My targets of choice when exercising my big bore revolvers are all inanimate, and jacketed bullet loads would unduly strain my wallet.