Needless to say, there are no cure-alls. Hypericum, however, is perhaps the most promising 'natural' healer for depression, dysthymia and everyday malaise which is presently available. Feel free to chop it up, pass it on, or put it up on your site. Information wants to be free. I think hypericin is an excellent alternative to commercial antidepressants, and ought to be made public knowledge.
Depression is hell.
I am researching neurotransmitter function from the belief that human existence should be basically blissful - with the necessary adversive reactions that ensure survival. I had been mildly depressed for most of my life, and wouldn't even know anything was wrong - except that I had a period of my life a few years back when my depression spontaneously disappeared for about a year. I have looked into many, many areas of human knowledge, from the most 'scientific' to the most mystical - and eventually most of them point to the serotonergic system as the mediator of human contentment. While I believe that western 'science' is the best tool we have available to us in this search for knowledge, as a basic paradigm it is fundamentally flawed, and I have a profound distrust of the medical profession, pharmaceutical companies, and all their surrounding corporate bedfellows. Epidemiological studies of metabolic disorders in indigenous people who have taken up western lifestyles and diets point toward hyperinsulinaemia and impaired glucose metabolism as a significant factor in the decline in health and well-being experienced by these people.