Also, BCG can't be administered to those that are immunocompromised or immunosuppressed. After 10 yrs., the efficacy of BCG diminishes. Prophylaxis also has its own set of side effects. These include loss of appetite, nausea, vomiting, persistant dark urine, jaundice, fever, and abdominal tenderness. Financial Needs Development of vaccines, immunizations, and TB programs requires an enormous supply of money.
Funding comes from several sources.
The WHO works closely with donor agencies in order to determine which countries are able to supply grants and loans for TB control. This funding is very limited which in turn limits the development of successful treatments and vaccines. It involves using patient funds to help meet the financial needs of the treatment. This way, more money could be put toward other preventive measures. However, considering TB is a public health issue, funding is the sole responsibility of the national governments.