Previous Positions 1987-1993, University of Washington, Dept of Laboratory Medicine, Asst Professor. 1984-1987, University of Washington, Dept of Laboratory Medicine, Acting Instructor. Dr. Chandler's primary interest is research on hemostasis and thrombosis.
Fibrinolysis is initiated by plasminogen activators in blood.
This project investigates how the level of fibrinolytic activity in blood is regulated by changes in the secretion, inhibition and clearance of plasminogen activators. It utilizes a combination of human studies on the fibrinolytic effects of adrenergic agonists, exercise, endurance training, cardiopulmonary bypass and other stimuli in combination with a kinetic model of the circulatory regulation of fibrinolysis. The effects of physical conditioning on fibrinolytic variables and fibrinogen in young and older healthy adults. A kinetic model of the circulatory regulation of tissue plasminogen activator. Fibrinolytic response during exercise and epinephrine infusion in the same subjects.