It also may have long-term benefits. These include slowing down the bone loss associated with osteoporosis and lowering the odds of heart disease. One great concern is that the long-term use of estrogen, alone or combined with progestin, might raise the risk of breast cancer. Some studies have found an increased risk in women who take hormones for more than 15 years. However, the validity of these studies has been questioned.
Extensive studies are under way in an effort to clarify the confusion.
Estrogen by itself is no longer given to any women with a uterus because it increases the risk of cancer of the lining of the uterus. Deciding whether or not to take replacement hormones is one of the biggest choices faced by women today. It is a highly personal decision that each woman should make in consultation with her doctor.