25 Melatonin Evening administration of valproic acid has been shown to decrease blood levels of melatonin, unlike placebo. Whether valproic acid may cause problems due to melatonin suppression when used as an anticonvulsant drug is presently unknown. Vitamin B6 Preliminary research has linked anticonvulsant therapy with possible depletion of vitamin B6 in children. 29 One study of 450 people living in Florida, who took anticonvulsants, found minimal evidence of anticonvulsant-induced bone disease, suggesting that regular exposure to sunlight may be protective. 30 Vitamin K Anticonvulsant drug therapy in pregnant women has been associated with vitamin K deficiency in the babies at birth.
Biotin catabolism is accelerated in adults receiving long-term therapy with anticonvulsants.
Disturbances in biotin metabolism in children undergoing long-term anticonvulsant therapy. Chung S, Cho J, Hyun T, et al. Alterations in the carnitine metabolism in epileptic children treated with valproic acid. Carnitine deficiency during valproic acid treatment. A double-blinded, crossover study.