For many sections, Cohen typically mounted passages from the previous edition on blank sheets of paper, writing links or revisions around the printed text. Both Series 3.1 and 3.2 follow the order of material found in the published volumes. Series 3.3 contains 141 folders of material for an unpublished third edition of Cohen's textbook. The manuscript seems to have neared completion in 1891. Some headings represent entire chapters, others subsections within a chapter.
Major subjects are coryza, diphtheria, esophagal and pharyngeal diseases, and tonsillitis.
Cohen revised his work constantly on the basis of new information or research of colleagues. Certain sections, such as chronic coryza and special affections of the pharynx, were revised many times. Whenever it has been possible to isolate a typescript section and its direct manuscript antecedent, the two items have been filed together. These addresses were delivered to professional organizations including the American Laryngological Association, the College of Physicians of Philadelphia, the Medical Society of the Statejof Pennsylvania, the New York Academy of Medicine, and the Philadelphia County Medical Society. Series 5 contains manuscripts and typescripts of some of Cohen's published scientific articles and book reviews, mostly concerning laryngology or tuberculosis.