Lesions occur in the mouth and on the skin. The pathogenesis is unknown, but proposed mechanisms include vasculitis, microangiopathy, a fibrinolytic disorder, a phagocyte function disorder, a catabolic enzyme release disorder, and a cell-mediated immunity disorder. Some feel that this is a hypersensitivity disorder. Multiple cutaneous papules, nodules, or plaques may occur over the ventral abdomen, prepuce, or flank. Cutaneous lesions usually are non-pruritic and painless.
Dogs are otherwise healthy.
Histologic changes include collagen degeneration, eosinophilic and histiocytic cellular infiltrates, and palisading granulomas. Lesions may undergo spontaneous remission. Lesions may recur. This is a descriptive term for a group of lesions affecting the mouth, mucocutaneous junctions, and skin of cats. 2. eosinophilic plaque 3.