Gemfibrozil is the drug of choice for therapy. Gemfibrozil, though not as effective as nicotinic acid, is better tolerated. Gemfibrozil should not be given to these patients. Biliary tract disease, pregnant women, obese patients, Native Americans. Gemfibrozil should be used with caution in these higher risk categories.
Gemfibrozil potentiates the action of coumarin and indanedione anticoagulants.
Risk of myopathy when gemfibrozil is given to patients receiving lovastatin.