The result is that both have a limited number of friends, if any, and miss some of the greatest pleasure in life. God even saw it wasn't good for a person to live a solitary life and made Eve for Adam. So those who reach out to others are helping fulfill a deep human need, and should be commended. She might need to do a bit of self-analysis, starting with the basics. Believe it or not, it's a consideration in the formation of friendships.
Few people enjoy an assault on their senses.
This includes sight and smell. If people are backing off as you speak, or wincing as they look at you, or even refusing to look at you, this could be a clue that you have a problem, and you might want to make a few improvements in this area. Most people like an opportunity to be heard. If you do all the talking, they don't get that opportunity, and soon lose interest in what you have to say. I recall one visitor to our home who never knew when to return to her own.