It has not been established whether low values are significant. Values are routinely measured every 3-6 months. This boronate affinity method is not subject to analytical interference by hemoglobin variants. However, factors that affect red blood cell survival can disrupt the normal relationship between mean blood glucose and glycated hemoglobin. For example, iron deficiency can lead to prolonged red cell survival with a consequent increase in the glycated hemoglobin result.
Hemolytic anemias can decrease red cell survival and lead to a decrease in glycated hemoglobin.
Klenk DC, et al.