These findings directly link human cancer mutational hotspot at codon 12 of K-ras to the preferential DNA damage and poor repair. Two forms of UvrC protein with different double-stranded DNA binding affinities. Human cells lack this protective mechanism, which may explain why humans and their cells are more sensitive to arsenite compared to rodents and rodent cells. Her laboratory has cloned 2 genes, which confer resistance to arsenite. T.G. Stable and inducible arsenite resistance in Chinese hamster cells.
Human cells lack the inducible tolerance to arsenite seen in Chinese hamster cells.