In 1915 Yamagiwa and Ichikawa deliberately produced malignant epithelial tumors by application of coal tar to the ears of rabbits. In 1922 Passey produced malignant growths by painting the skins of mice with coal tar ethereal extracts. Smaller doses and relatively short exposures to 2-napthylamine are very hazardous in man 5,7. Tumors induced by coal tar dyes develop from 3 to 36 years after exposure 5,6. It is worthy of note that it was in 1905, that Einhorn developed the local anesthetic, novacaine, from the aniline homolog, hydroxyaniline.
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