Deploy encryption, authentication technologies, and use automated confidentiality tools. Just remember that people will need to use these tools and people are vulnerable. Doctored data can create more damage than stolen data. Moving a decimal during an audit could prove disastrous. Even product designs can be surreptitiously tampered with to produce structural failure, liability exposure, and damaged corporate reputation.
Any organization operated by people has inherent vulnerabilities.
To insure information integrity, start with your people. Regularly back up and restore based on the cost of manually rebuilding data. Never blindly accept what you see on the screen. Your employees need to work in a supportive technological environment. Paying people to come to work and play solitaire on their computers when they cannot access the network or their files is a waste of time, labor, and resources.