The multiple alignments were then scanned for the presence of sequence fragments. If an alignment contained one or more fragments, then additional alignments were created by removing each of the fragments from the original alignment. The positions of the conserved regions within each sequence along with the information on sequence family membership were then collected and stored in a local database. This table is omitted for the CRAnnot database searches. Hits within all or most of the known conserved regions within a database sequence are much more likely to be functionally important than hits within non-conserved domains.
Hits matching known domains and sites are readily discernible.
Human Genome Sequencing Center, Baylor College of Medicine .