My research focuses on solving three key problems to forge structure-based drug design into a powerful method that will create the drugs of the 21st century. The current expertise on chemical stability, drug metabolism and toxicity will get incorporated in design strategies so that tightly binding inhibitors can be turned more easily into drugs. Thus far, significant progress has been achieved in the design of anti-trypanosomal compounds .
Efforts are underway to arrive at prophylactic drugs for cholera and related diseases.