But the individual may die of other causes, such as an automobile accident, before the heart disease manifests itself. Another explanation isolated cases of autosomal dominant disorders in non-paternity . Not everyone who has the disease is affected in the same way. Some of the variation is in the tissues affected and some in severity. Take cystic fibrosis for example.
All patients have lung damage but only some have pancreas damage.
This refers to a single disease caused by mutations in different genes. For example, we now that most women who inherit a strong predisposition to breast cancer have mutations in one of four genes. Because if you want to test for inheritance of a families predisposition, you need to know which gene is affected in that family. I. This is a common, fully penetrant, autosomal dominant disorder. Incidence 1 in 3000 4000.