Apply on moistened skin in thin skin areas such as back of the hand, side of the neck, inside the wrist all the way up toward the underarm, etc. It is recommended to alternate application areas every few days so that no one area becomes overused. A small percentage of women experience breast tenderness for a short time when beginning to use natural progesterone. This passes shortly and well-being is enhanced. Progesterone is the key factor in the biosynthesis of other hormones, and it also has many other important functions in the body.
Hormones convey their messages only where receptors are available.
The range of progesterone receptors throughout the body illustrates the multiple roles of progesterone. Progesterone has been used in studies to prevent endometrial hyperplasia, to stop menstruation, stop ovulation, and it has been approved by the F.D.A. for treating amenorrhea. However, when progesterone is taken orally, it is absorbed and transported to the liver where 80 to 90 percent is converted to metabolites which are meant to be excreted by the body. This is why doctors using oral progesterone have to prescribe doses as high as 200 mg per day to get results. Since some of these metabolites do enter the general circulation and have undesirable side effects, oral dosing should be avoided.