These androgens are subsequently transformed in the ovary into estrogens. LH stimulates the production of androgens. It stimulates cholesterol pick up and transformation into androgens. In a state of anovulation, in which there is no cyclicity, continuous production of estrogens maintain high levels of LH which in turn increase androgens. Because FSH is decreased, these androgens are not rapidly converted into estrogens.
Androgens also inhibit their own transformation into estrogen in the ovary.
Attached to this protein, sex hormones are inactive. Weight loss in itself occasionally corrects the problem. Less fat decreases the transformation of androgens into estrogens . Lower estrogen levels may increase FSH and promote the development of eggs and the transformation of androgens into estrogens in the ovary to levels sufficient to induce a big surge of LH which triggers ovulation. The condition is the consequence of an excess production of corticosteroids in the adrenal gland.