This module is based on an article by H. Harcourt, A. Sanchez, and K. Offermann. 1999. 1b, in Endothelial Cells.
Filoviruses can grow and cause sever damage to the liver, spleen, lymph nodes and lungs.
Endothelial cells play an important role in the host antiviral response through the expression of a number of immunomodulatory genes that are induced by viruses or cytokines . INF plays an important role in the host's antiviral responses by inducing immunomodulatory genes. These observations led to the hypotheses that EZ selectively blocks IFN signaling and therefore investigated in endothelial cells. To look at how the investigators arrived to their conclusion navigate through this web page by clicking on the experiments on the menu bar and results at the end of each experiment. Underlined words are described by clicking on them.