In addition, there is currently no method available to target therapies to the Golgi apparatus, the small subcompartment of the cell where the LS enzyme is located. The LS gene is located on the X-chromosome. Only males can actually have the condition. Females who have the LS gene are carriers. In some cases, LS is the result of an original mutation and the mother is not a carrier.
Genetic testing can also help to determine carrier status.
Various family planning options are available, including prenatal testing. Families should consult with a geneticist to learn more about their options. To diagnose LS, a small skin sample is taken and sent to the Biochemical Genetics Laboratory at Baylor College of Medicine in Houston, Texas. Prenatal diagnosis is also provided at this lab. Genetic testing is done through the Baylor College of Medicine DNA Diagnostic Laboratory.