Medication There are over 200 prescription drugs that may directly cause or contribute to impotence. Among these are drugs for high blood pressure, heart medications, antidepressants, tranquilizers and sedatives. Remember, even if you suspect drug-related impotence, do not discontinue taking prescription medication without first consulting your physician. Chronic use of non-prescription recreactional drugs such as alcohol, as well as use of illegal drugs, can also cause impotence. An excess of the hormone Prolactin, which results from tumors in the pituitary gland, reduces levels of testosterone.
Hormonal imbalances contributing to impotence can also occur as a result of kidney or liver disease.
Peyronie's Disease Peyronie's disease is a relatively rare inflammatory condition that causes scarring of the erectile tissue in the penis. This scarring produces a curvature in the penis that can interfere with sexual function. In addition, it may cause erections to be painful. Cancer surgery, in particular, often requires removing extra tissue and nerves surrounding the affected area, which increases the chances that impotence will occur. Removal of the prostate or bladder often results in impotence.