A tentative diagnosis of lymphoma was made, based on the gross findings. Similar yeast forms were also evident in the spleen, lungs, liver, bone marrow, brain, kidneys, and adrenal glands. These morphologic characteristics are diagnostic of infection with Cryptococcus neoformans .
Infection is usually by inhalation of aerosolized organisms.
Cryptococcal yeast forms vary from 2 - 15 m m in diameter, and are usually spherical.