The endocrine component of the pancreas consists of group of cells called the islets of Langerhans. The islets are scattered within the glandular tissue of the pancreas. These islets have associated with them an extensive fenestrated capillary network. Cirrhosis is a disease of the liver in which hepatocytic injury induces diffuse architectural disorganization and varying degrees of fibrosis accompanied by nodular regeneration of hepatic tissue. Scan your slide on low magnification and note the various amounts of fibrous tissue scars formed in response to loss and injury of hepatocytes.
Connective tissue is infiltrated by lymphocytes and often contains portal triads.
Very often, lobules lack central veins and have abnormal vascular architecture. In some areas on your slide note extensive accumulation of the lipid droplets in the cytoplasm of hepatocytes. Accumulation of brown lipofuscin pigment is also evident in some cells. Observe small areas of necrosis marked by clusters of red-stained neutrophils. This is a good slide to review normal histology in the areas not affected by cirrhosis.