Amprenavir may be taken with or without food, although a high-fat meal decreases the drug's absorption and should be avoided. Capsules and solution should be stored at a room temperature of 68 to 77 F. Side effects and toxicity. Hemophiliacs may experience increased bleeding. Amprenavir therapy should be discontinued in patients with this syndrome and those with moderate rashes accompanied by systemic symptoms. Amprenavir should only be used during pregnancy if potential benefit outweighs risk.
Data are incomplete and animal studies show adverse effects on the fetus.
When combined with efavirenz, an adjusted 1200 mg dose 3 times a day is recommended. Resistance and cross-resistance. The mutation at position 50 is associated with high-level resistance. For those who qualify, Glaxo Wellcome offers a patient assistance program. For more information, call 800.722.9294.