Angiogenesis differs from vasculogenesis in which vessel rudiments become organized to form mature vessels. Angiogenesis is fundamental for healing, reproduction, embryonic development.
Angiogenesis is dependent upon production of angiogenesis-stimulatory and inhibitory molecules.
An imbalance in this regulatory circuit might lead to the development of angiogenesis-mediated disorders. Angiogenesis can be temporarily activated in particular situations as wound healing and ovulation. The microenvironment in an organ controls the extent of vascularization under physiological and pathological conditions. 3. development of capillary tubes with formation of tight junctions and deposition of new basement membrane. The tumor switches to an angiogenic phenotype by a change in the balance between positive and negative regulators of angiogenesis, to evoke new capillary vessel formation.