The increased porosity allows more of the aminoglycoside into the bacteria cell. Traditionally, aminoglycosides were administered at even doses given throughout the day. It was thought that a steady plasma concentration was necessary to combat infection. However, this administration schedule is time and labor intensive. Furthermore, administering a single daily dose can be as effective, or more effective, than several doses throughout the day.
Dosage depends on the patient's age, weight, gender, and general health.
Since the drug is cleared by the kidneys, it is important to assess any underlying problems with kidney function. Kidney function is assessed by measuring the blood levels of creatinine, a protein normally found in the body. If these levels are high, it is an indication that the kidneys may not be functioning at an optimal rate and dosage will be lowered accordingly. Risks Aminoglycosides have been shown to be toxic to certain cells in the ears and in the kidneys. However, in most cases the damage is minor and reversible once medication is stopped.