Incorporating site 73 into a phylogenetic analysis otherwise identical to that of Richards et al. We suggest that the lineages carrying an A at site 73, together with some other lineages, perhaps have their origins in a small founder population which expanded after the last glacial maximum about 20,000 years ago. Adenine at site 73 would thus have been common amongst the hunter-gatherers who inhabited Europe before the spread of agriculture from the Middle East. I sequences, site 73 is worth determining in studies of Caucasian populations. An approach to the choice of experiment to aid prediction is proposed in a Bayes decision-theoretic framework.
Estimation is included as a special case.
We characterize coherent design criteria which are functions of the dispersion matrix and their associated decision problems. Connexions are established with the classical approach to optimal design theory for the normal linear model thus making its optimization techniques available for suitable problems in this new setting. A revised and retitled version of this paper has appeared in Ann. No abstract available. No abstract available.