In the absence of vitamin D, calcium is poorly absorbed, the bone matrix is deficient in calcium, and the bones are likely to be deformed or very weak. Vitamins A and C also are needed for normal bone growth and development as well as adequate supplies of calcium and other minerals in the diet.
Growth hormone is also an important factor in regulating bone growth.
Local factors, as well as systemic factors, especially influence bone remodeling. Local factors are chemicals secreted directly by the actual bone cells onto the remodeling matrix and tend to effect that particular local area. Systemic factors are usually hormones made by a gland and secreted into the blood stream. These chemicals then travel throughout the body influencing many bones and other systems simultaneously. The KIE Group.