Role of cis-acting sequences of the ICP0 promoter of herpes simplex virus type 1 in viral pathogenesis, latency and reactivation. The virion host shutoff function of herpes simplex virus type 1 plays a role in corneal invasion and functions independently of the cell cycle. Analysis of the basal and inducible activites of the ICP0 promoter of herpes simplex virus type 1. Identification of the UL4 protein product of herpes simplex virus type 1. Leib, D.A., Harrison, T.E., Laslo, K.M., Machalek, M.A., Moorman, M.J., and Virgin.
Interferons regulate the phenotype of wild-type and mutant herpes simplex viruses in vivo.
Herpes simplex virus virion host shutoff activity alters periocular disease in mice. M.A. Machalek, B.R. Williams, R.H. Silverman, and H.W. Virgin. Specific phenotypic restoration of an attenuated virus by knockout of a host resistance gene. L.A. Disruption of virion host shutoff activity improves the immunogenicity and protective capacity of a replication-incompetent herpes simplex virus 1 vaccine strain. Summers, B.C., Margolis, T.P., and Leib, D.A. Herpes simplex virus causes periocular disease through zosteriform spread.