T his approach allows the identification of cellular sites of mutant gene action and the tracing of cell lineage. The neurohistological techniques we employ to study this problem are in situ hybridization, immunocytochemistry, and image analysis. We also use embryo manipulation, gene mapping using special breeding schemes and microsatellite markers, and extreme thoughtfulness in our studies of brain development. The structure of clonal and polyclonal arrays in chimeric mouse retina. Genetic mutations affecting murine cerebellar structure and function.
Hybridization analyses of nervous system gene expression.
Mouse chimeras in the study of genetic and structural determinants of behavior. Trends in Neurosci. Tune into the weaver channel. Invariable decussation ratios in strains of albino mice with variable ganglion cell numbers. Developmental regulation of various annexins in the embryonic palate of the mouse, submitted.