We are investigating these phenomena further in the projects described below. The main tissue culture project is investigating whether activation of adenosine receptors induces changes to the expression of cellular proteinsor genes. The effect of adenosine on expression of various proteins is measured using immunocytochemistry. This research may lead to more effective therapies to prevent neurons from stroke-induced destruction, thereby improving stroke outcomes in patients. Clearly, this goal is desirable for the families as well as the health care system.
Freshwater turtles possess one of the most anoxia-tolerant nervous system of all vertebrates.
During a dive, adenosine release increases and extracellular adenosine controls cerebral blood flow. Adenosine may be the key mediator of the regulation of turtle brain function during the transition from normoxia to hypoxia i.e. involved in making the brain more able to withstand periods of reduced oxygen. My research should study this issue further and address possible mechanisms for this action. Cellular mechanisms involved in brain ischemia. Sweeney M.I. .