You will want a central location that draws air from all parts of the house. Because the fan can be noisy, find a spot where it will not disturb anyone. You probably will want to run the fan at night, so try to keep it away from bedrooms. These big fans create a strong breeze. Avoid rooms where papers and other light objects could fly around.
Kitchen appliances generate much heat.
Placing the whole house fan near the kitchen can be a good idea. When nights are a lot cooler than days, you can ventilate at night to clear the heat out of the building. This works best when your home is made of dense materials, such as plaster, concrete, brick or stone. These materials absorb and hold much heat. Night flushing cools the building, so it begins the next day at a lower temperature.