Unlike ground squirrels, tree squirrels do not hibernate. Squirrels feed on nuts and seeds, fruits and other plant material, supplemented with a few insects. They have also been known to feed on reptiles and young birds. In the Zoo Prevost's squirrels are fed monkey chow, fruit, peanuts, and sunflower seeds. Squirrels are sexually mature and able to breed when approximately one year old.
Gestation lasts about five weeks.
Infant squirrels are born naked, toothless and helpless with their eyes closed. By six weeks of age they are fully furred and sufficiently independent to be able to venture out of the burrow.