There are no roads into the preserve and most trails are used only in the winter. In general access is via plane or boat. People wishing to get a Yukon River experience can either arrange their own transportation, take the Yukon Queen, which plies the waters upriver from the preserve between Dawson and Eagle, or contact a commercial transport operator. There are no commercial facilities of any kind located within the preserve. Visitors should always carry all necessary supplies with them.
Float times vary depending upon weather and water conditions.
Filing a float plan with the Visitor Center in Eagle and a friend or relative is highly recommended. Safe storage of food supplies will deter wildlife advances and protect visitors from unnecessary loss of food and equipment.