In euthyroid patients, doses within the range of daily hormonal requirements are ineffective for weight reduction. Larger doses may produce serious or even life-threatening manifestations of toxicity, particularly when given in association with sympathomimetic amines such as those used for their anorectic effects. Thyroid hormones should be used with great caution in a number of circumstances where the integrity of the cardiovascular system, particularly the coronary arteries, is suspect. In patients with compromised cardiac functions, use thyroid hormones in conjunction with careful cardiac monitoring.
Extreme caution is advised when administering thyroid hormones with digitalis or vasopressors.
See full prescribing information for a more detailed discussion of important safety information.