If uine gets in the mouth, rectum, or in the eyes, a possibility of infection is clearly present. Enemas, not so common anymore, should involve lukewarm not cold water, and of utmost importance, require a sterile environment. Beer and wine should not be used. If they are, the rule of thumb is that they be used in quantities smaller than you could safely drink since the intestines absorb alcohol more rapidly into the system than drinking can. There are risks, however.
Infection is common enough even in the hospital.
In a sexual environment the procedures necessary to create a sterile field can be a turnoff to many but a turn on for some. Only persons experienced in sterile procedure should attempt it. Nothing that is not sterile should be introduced into the urethra of either males or femalesthe risk of infection is great. Other precautions regarding the possibility of preexistent urinary tract infections should be heeded. The equipment must be carefully checked to make sure it is in working order and the operator, experienced.