Neurotoxic reaction are manifested by a fine tremor, paresthesias and, occasionally, seizures. This effect regresses as the dosage of Cyclosporin is lowered. Inc. Exploration of the possibility of using the donor heart as an accessory pump had been carried out previously in laboratory experiments, most notably by Demikhov. Two techniques were developed at the university of Cape Town, the first of which was a means of bypassing or supporting the left ventricle only, and the second a means of biventricular support. Recipient heart may maintain circulation after irreversible rejection while awaiting a second donor.
Heterotopic transplant allows for some possible recovery of the recipient heart.
Can be performed even in the presence of a high pulmonary vascular resistance. Disadvantages Risk of systemic emboli from clots in the poorly contracting recipient left ventricle. Continuing angina related to recipient ischemic heart muscle. John W. Kirklin, Brian G. Barratt-Boyes. The technique of orthotopic heart transplantation has been well established for more than 30 years, based on the first description by Lower, Stofen, and Shamway.