With pH alteration or immunosuppression, this yeast can overgrow and cause inflammation. Visible as white dots on mucosa. Coccidioides immitus . TB-like symptoms and signs. Primary lung infection can spread systemically to affect multiple organs.
Blastomycosis is caused by Blastomyces dermatitidis .
Infection is either primary to the lungs with spread via blood to cause skin ulcers, or by infection of the skin from a contaminated splinter, with blood spread to the lungs and other skin sites. Diagnosis Diagnoses of fungal infections is by history, sometimes radiography, and of course a physical examination. Combine with ergosterol molecules of fungal cell membranes. Bacteria do not have sterols in their membranes and human cells have cholesterols, not ergosterols. Interfere with sterol synthesis in fungi.