The variation within the four diagnostic groups was high and significant differences were not apparent between group means. Histologic diagnosis, sex, plasma estradiol concentrations, and percentage of estradiol immunoreactivity in adrenal gland tissue sections. Carcinoma F 322 31.0 Table 2. Histologic diagnosis and mean percentage of area of estradiol immunoreactivity in normal, hyperplastic, and neoplastic adrenal glands of ferrets. Normal adrenal gland, ferret, estradiol immunostaining with hematoxylin counterstain, 40X magnification.
Adrenocortical cells lack estradiol reactivity.
Nodular adrenocortical hyperplasia, ferret, estradiol immunostaining with hematoxylin counterstain, 40X magnification. Foci of adrenocortical cells exhibit mild but variable estradiol reactivity. Adrenocortical adenoma, ferret, estradiol immunostaining with hematoxylin counterstain, 40X magnification. Diffuse, moderately intense estradiol immunoreactivity is apparent. Adrenocortical carcinoma, ferret, estradiol immunostaining with hematoxylin counterstain, 40X magnification.