Bradycardia is a serious adverse event and the effects of adenosine are not blocked by atropine. Adenosine should only be used where cardiac monitoring and resuscitation equipment are immediately available. Adenosine for PSVT Study Group. Adenosine in the diagnosis of broad complex tachycardia. Its antimicrobial activity is similar to that of cefotaxime.
Clearance is mainly renal so a lower dose is given if creatinine clearance is reduced.
The halflife is 2 hours, but cefpirome can usually be given twice a day. Cefpirome is stable to beta lactamases and has activity against staphylococci, streptococci, and Gramnegative organisms including Escherichia coli , Haemophilus influenzae and Moraxella catarrhalis . The drug is active against Pseudomonas aeruginosa , but may be less active than ceftazidime. The results of clinical trials have led to cefpirome being approved for the treatment of serious or lifethreatening infections. It can be given for septicaemia, infections of the lower respiratory tract, skin and soft tissues and complicated infections of the urinary tract.