Chemical abundances provide important clues to the evolution of galaxies.
Ionized nebulae are one of the main sources of chemical abundance measurements, especially in external galaxies. Studies of H II regions have shown that the overall metallicity of galaxies increases with galactic luminosity, and that spiral galaxies characteristically have radial gradients in chemical composition. There are indications of environmental influences on chemical abundances. Planetary nebulae provide another measure of abundances in the Milky Way and other galaxies. Space facilities have allowed measurements for elements that are inaccessible at optical wavelengths.