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This information is brought to you to keep you informed of new and updated information in pharmacy, it is not meant to be a substitute to your own doctor or pharmacist's recommendations, but rather as a supplement. The drug is manufactured by Glaxo-Welcome. Lotronex has not been shown to work in men with irritable bowel syndrome. Lotronex acts to treat irritable bowel syndrome by blocking a chemical called serotonin. This chemical is thought to be responsible for the overactivity of the colon that occurs in irritable bowel syndrome.