Sometime ago we had a discussion on dermal patches.
Any input is appreciated.
Most of this was described in the literature over 10-20 years ago. Trends in Pharmacol. With the new COX-2 inhibitors, there is a real need to identify more clearly which mechanism of action pertains for each new agent. Sometime ago we had a discussion on dermal patches. If you had to apply the cream to each of the affected joints in a case of arthritis it would get very messy and would possibly produce the same side effects as the amount absorbed would necessarily increase with the increasing surface area.