The research emphasis in this laboratory focuses on the molecular toxicology of Phase II detoxifying enzymes.
Conjugation reduces their biological reactivity and enhances their rate of excretion.
Because carcinogens represent one of the most important classes of hazardous substances metabolized and detoxified by Phase II enzymes, our effort is directed at understanding the roles of Phase II enzymes in carcinogenesis and anticarcinogenesis. Our long-term goal is to better understand the Phase II enzymes as positive or negative risk factors influencing individual susceptibility to carcinogenesis. Laboratory animals are protected from the cancer-causing effects of carcinogens when selected Phase II enzyme inducers are administered prior to chemical carcinogens. The potential use of Phase II enzyme inducers in humans for prevention of cancers related to exposure to carcinogens has prompted studies aimed at understanding their molecular effects. Our laboratory is utilizing biochemical and molecular biological research methodologies to identify and characterize the targets of selective Phase II enzyme inducers.