Histological findings of the tumor tissue showing an area of atypical medullary carcinoma. The carcinoma tissue forms a solid pattern with extensive necrosis. Marked infiltration of lymphocytes is observed. A B Figure 5. Histological findings of the tumor tissue showing an area of cartilaginous metaplasia.
Cartilaginous matrix is seen between cancer cells of high-grade atypia.
After obtaining the written informed consent of the patient, we examined the patient's DNA, which we extracted from lymphocytes, for BRCA1 and BRCA2 germline mutations. The patient was given basic information about the genes and the possible risks of psychological distress and social discrimination. No BRCA2 mutation was detected in the regions tested. No other family members were examined. In the present case, the same nonsense germline mutation of BRCA1 was detected.