However, that term has since come to be used for earlier-arising lesions, which appear to be more closely related to infectious mononucleosis. The appearance is similar to the previous needle biopsy of the retroperitoneal lesion.
Clinical correlation is required.
Occasional positive small lymphocytes are seen with the EBER in-situ hybridization, which is performed on a research basis on the renal tissue in Part 2. No evidence of lymphoproliferative disorder is seen in the kidney and these cells are interpreted as representative of the resting B-lymphocyte population, which is infected with EBV, likely in a latent form. The histopathologic appearance in some cases may be that of infectious mononucleosis. The heterogeneity of cell sizes has led to the use of the term polymorphic to describe these lesions. We originally proposed the term monomorphic PTLD to describe these latter lesions and to separate them from the polymorphic PTLDs.