Small ulcers missed by barium can be picked up by endoscopy. Medical Management Healing of ulcers and relief of pain are the two objectives. Antacids like aluminium hydroxide and magnesium hydroxide are most commonly used. The former produces constipation, and the latter diarrhoea in some patients. Antacids could be taken one hour after each meal and at bedtime.
Agents preventing the binding of histamine to receptors are very helpful.
Acid secretion is lowered. They are taken with meals. Side effects are minimal, though they include rash, gynaecomastia, mental confusion and increasing the action of other drugs. Ranitidine, nizatidine and famotidine are effective. Omperazole is a promising drug.