The vaccine used in infected herds should be identical with the serotype causing the diseases, as there is little or no cross-protection between vaccine serotypes. The vaccine should be given to all susceptible livestock on the premises where infection has been identified. The future breeding efficiency of herds that have experienced leptospirosis is usually unaltered. Animals should not be culled because they have had the disease. In fact, their value may be enhanced because they are solidly immune against re-infection with the same serotype.
Annual vaccination is recommended for dogs with a booster given if an outbreak occurs in the area.
In the face of an acute outbreak of leptospirosis in swine, it is recommended that chlortetracycline or oxytetracycline be added to complete rations for two to three weeks at the highest levels for which it is cleared. Vaccination of the entire herd can be accomplished at the same time. By following this procedure, immunity can be established in the herd before the antibiotic is removed. Dihydrostreptomycin can also be given to new additions, such as boars, to clear them of the Leptospira carrier state. Use a single injection of 10 mg per pound.