This accelerates the damage. In response, damaged joint tissues release enzymes that erode the cartilage and break down the thick, lubricating synovial fluid into a watery liquid, destroying its lubricating quality and reducing cartilage nutrition at a time when it is desperately needed. The initial injury expands, more enzymes are released, and a vicious cycle of joint degeneration is under way. It isn't until the damage reaches the joint capsule or subchondral bone, where sensory nerves are located, that signs of pain appear. By then, considerable damage has already occurred.
Canine link below.
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