Can cause asthma in aspirin-sensitive individuals. Multiple doses can damage the stomach and cause other toxic effects. Aspirin also interferes with ovulation in female rats. As above, choose the dose based on the type of pain and length of use. Also prolongs bleeding, but only while it is in the system.
Chronic use can cause bleeding, ulceration, and perforation of the stomach.
Ibuprofen causes fluid retention and decreased blood flow to the kidneys, so is more risky to use in the elderly, or if the patient has heart or kidney disease, or is on diuretics. Debbie recommends .25 to 1 mg though unless there is surgery being performed.