In ACTH, hypersecretion hyperplasia of fasciculata and reticularis are seen. Bronchogenic carcinomas and other neoplasms may secrete ACTH-like substances. Mineralocorticoids Are controlled by potassium and angiotensin levels. A newly described 26KD glycoprotein has been found in the pituitary and serum that also controls electrolytes. Decreases Leukocyte adhesion and diapedesis, inflammation, bacterial lysis in leukocytes, numbers of T-cells, and inhibits migration of water into cells.
Decreased aldosterone results in contraction of extracellular fluid and potassium retention.
Accentuates male characteristics and suppresses female characteristics. Disorders that cause increased output of steroids. Hyperplasia or neoplasia. Lesions with no hormonal function defect. All cause steroid secretion abnormalities, inducing Adrenogenital Syndromes.