Natriuretic Hormone is a digitalis -like compound. It increases sodium excretion and arterial pressure. Besides the filtering and immunologic functions, the spleen is a reservoir for blood cells. These elements can be released under adrenaline stimulation. Symptoms of hypersplenism .
Anemia is mild and mostly due to increased sequestration of red cell in the spleen.
Tthrombocytopenia due to increased storage of platelet pool in the enlarged spleen. The platelet count is inversely related to the size of the spleen. Granulocytopenia is usually mild. Granulocytopenia in hypersplenism seldom represents a problem for the patients in fighting infections because they are able to mobilize more required white cells from the bone marrow. 5-Treatment of portal hypertension .