So blue residues are in almost the same position in the two models, while other colors indicate residues that move to accomodate the hapten. Try to retain a general impression of the amount of local movement needed to accomodate the hapten. After comparing the models in the hapten-binding region, display the full models and compare them. Try to retain a general impression of the amount of difference between them. Blink to compare the models.
Coloring is the same as in the first two layers.
After comparing the models in the hapten-binding region, display the full models and compare them. This allows you to compare the germline and mature antibodies directly. Yellow residues are those that mutated as germline antibody evolved into mature antibody. These mutations are responsible for the fact that mature antibody has much higher affinity for hapten. To Topics List .