Ingestion of single high doses of HFC-152a caused weight loss and lethargy. Inhalation of high levels of HFC-152a caused labored breathing, lung irritation, lethargy, incoordination and loss of consciousness. Cardiac sensitization occurred in dogs exposed to a concentration of 150,000 ppm in air and given an intravenous epinephrine challenge. Repeated inhalation exposures caused increased urinary fluoride, reduced kidney weight, and reversible kidney changes. Based on an independent peer review the reversible kidney changes are considered artifacts of the tissue and slide processing and not a compound related effect.
Animal testing demonstrate no carcinogenic activity nor developmental effects.
No animal data are available to define reproductive effects of HFC-152a. HFC-152a has not produced genetic damage in bacterial cultures. It has not been tested in animals. Comply with Federal, State, and local regulations. This material may be a RCRA Hazardous waste upon disposal due to the ignitability characteristic.