Together, they lead a team of over 35 University of Pennsylvania researchers, including Penn undergraduates, School of Medicine graduate students, postdoctoral fellows, technicians, and research associates. Given the mission of the Center to facilitate the development of better diagnostic strategies and effective new therapies of these disorders, CNDR encourages the rapid translation of progress at the lab bench to the bedside. Indeed, wild type alpha-synuclein may aggregate by itself or with other proteins into LBs and dystrophic neurites in the absence of a mutation, as is the case for tau in AD and other sporadic tauopathies. Thus, it is likely that clarification of this enigmatic symmetry in any one of these disorders will have a profound impact on understanding the mechanisms that underlie all of these disorders as well as on efforts to develop novel therapies to treat them. This table summarizes neurodegenerative disorders characterized by filamentous brain lesions in the extracellular space or within neurons or glia.
AD is a heterogeneous dementing disorder, and one of several tauopathies.
Cell Death Diff.