Members of the genus Fusarium are ubiquitous fungi uncommonly associated with infection. Human infection usually occurs as a result of inoculation of the organism through the body surface, thus causing skin infection, onychomycosis, keratitis, endophthalmitis and arthritis. Fusarium is one of the fungi that can produce micetoma. Dissemination may occur in subjects with underlying immunodeficiency Disseminated fusariosis typically occurs in neutropenic hosts and carries a high mortality rate.
Central pallor is followed by necrosis and ulceration.
Blood cultures have been positive in 59 percent of cases, including a few that seemed to be due to infected central venous catheters. Amphotericin B is the drug of choice, although it appears to be poor correlation betwween in vitro susceptibility and clinical response. Survival was related to the resolution of the neutropenia. Rabodonirina M, Piens MA, Monier MF et al. Their experience with 5 cases and review of all cases from the literature.