They have proven the most useful in their role as an anti-inflammatory. It was initially discovered that aspirin exerts a potent anti-inflammatory effect because of its ability to block the first step in the synthesis of prostagladin. Prostaglandins are also important to the normal functioning of a number of other processes including digestion. Additionally, they should be used with caution if the patient suffers from indigestion or heartburn. In addition to gastrointestinal upset, there are other less frequently occurring side effects that vary according to the individual and the specific drug.
Allergic reaction can involve a rash, difficulty breathing and swelling of the face.
For an itchy rash or swelling the patient may benefit from the administration of an antihistamine. Should dyspnea occur, it is necessary for the patient to seek immediate medical attention. They are also contraindicated during pregnancy, breast feeding, while on an anticoagulant, active peptic ulcer and for those with a defect in the normal blood clotting system. They should be used cautiously for patients with asthma, renal impairment, cardiac disease and impaired hepatic function. The most widely used forms are tablet or capsule given by oral administration.