Renal tubular reabsorption of calcium is not affected.
Absorption is affected by food or preparations containing divalent ions.
The drug remaining in the body is adsorbed to bone, where therapeutic effects for Paget's disease persist 3-12 months after discontinuation of the drug. Heterotopic ossification due to spinal cord injury or total hip replacement. Hypercalcemia of malignancy inadequately managed by dietary modification or oral hydration or which persists after adequate hydration is restored. Enterocolitis, fracture of long bones, hypercalcemia of hyperparathyroidism. Safety and efficacy have not been established in children.