The genes thus identified will serve as a starting point for dissecting a complex part of Plasmodium's life cycle and maybe potential drug and vaccine target. The invasion step is one of the proposed targets for intervention strategies both based on drugs as well as vaccine. A.A. Thathy, V., Frevert, U., Robson, K.J.H., Crisanti, A., Nussenzweig, V., Nussenzweig, R.S., and Menard, R. 1997. TRAP is necessary for gliding motility and infectivity of Plasmodium sporozoites. Menard, R., Sultan, A.A. Cortes, C., Altszuler, R., van Dijk, M.R., Janse, C.J., Waters, A.P., Nussenzweig,R.S.and Nussenzweig, V. 1997.
Circumsporozoite protein is required for development of malaria sporozoites in mosquitoes.
Sultan, A.A., Briones, M.R.S., Gerwin, N., Carroll, M.C., and Nussenzweig, V. 1997. Sultan, A.A., Thathy, V., Nussenzweig, V., Menard, R. 1999. Green fluorescence protein as a marker in Plasmodium berghei transformation. Sultan, A.A. 1999. Molecular mechanisms of malaria sporozoite motility and invasion of host cells.