Since someone claimed that Frontline was not safe for ferrets, I will address that first. That is from the book Muller and Kirk's Small Animal Dermatology 6th edition 2001. This article was by Dr Bruce Williams. He list both Frontline and Advantage for use on ferrets. Frontline will also kill ticks and when put into the ear will also kill ear mites.
Advantage just kills fleas.
It worked well for 1 week. It lasted for 3 weeks. Duration of activity therefore appears to be dose related. Something to think about if you are dividing the tube into smaller amounts. In addition baths will remove some of the Advantage as well.