Some things simply do not make sense, and clinicians must stay alert to this type of situation. Perhaps an RCT reports study results in which research methods were so complex that the majority of subjects dropped out before data collection was completed. Common sense should alert you to read and interpret these results carefully. In clinical practice, common sense is especially important. For example, if a math calculation results in a dosage of 100 tablets to be given at one time, you should realize that is incorrect.
Common sense can protect patients in almost any clinical situation.
There are many ways to make a clinical decision. Research never will answer every question or issue. When confronted with a problem, think of all possible approaches to solve it. Start with a literature search to determine if an answer exists. If not, then decide whether the problem is researchable.