He moved from Tennessee to Alexandria, Louisiana in 1819 where he operated a steam boat, a sawmill and ran a plantation. The papers relate to the business and legal career of Isaac Thomas. Several papers document the history of land ownership in Rapides and Catahoula Parishes, La. Letters and legal papers document the practice of law in Louisiana.
Correspondence is in English and French and largely concerns legal and financial business.
Papers are in French and English. A letter of 1823 relates to the estate of Abner Harrison. Memoranda, Tract Society Minutes, n.d. Materials include minutes of a meeting held in Alexandria to set up a local division of the American Tract Society.