Barry T. Rouse, UT College of Veterinary Medicine University of Tenneessee College of Veterinary Medicine Rouse, Barry T., B.V.Sc., Ph.D., D.Sc. Immunobiology and immunopathology of virus infections. We are attempting to understand the molecular and cellular mechanisms involved in the pathogenesis of HSK with a view to defining means of controlling these lesions which are an important cause of human blindness. The disease process appears to result from a pathological immune reaction against viral proteins or host proteins induced following infection or by a bystander mechanism of activation. The mechanism of immunopathology as well as its modulation is under investigation.
Current research emphasizes DNA vaccines given via mucosal routes.
A range of in vivo and in vitro test systems are used to evaluate efficacy. In addition, we are attempting to define the relevance of cross-priming during immunization against viruses and determining how the cross priming process is mediated in vitro and in vivo. Thomas, J., and B. T. Rouse . Gangappa, S. P., E. Manickan, and B. T. Rouse . Control of herpetic stromal keratitis by CTLA-Ig.