Angiogenesis is induced by tumors as a lifeline for oxygen and nutrients.
Angiogenesis inhibitors can cut off a tumor s blood supply, which will in turn starve the tumor and save the patient. Angiopoietin-1 is a gene that has been shown to play an indispensable role in blood vessel development. Recent study has also proven that Ang-1 directly acts on human endothelial cells and interacts with other angiogenic molecules to stabilize vascular structures by promoting the survival of differentiated endothelial cells. The purpose of this project was to determine whether or not the Angiopoietin-1 gene is present in human ovary tissue. Through the use of polymerase chain reaction to amplify the genetic material, and through DNA purification, it was determined that the Ang-1 gene is present in human ovary tissue.