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Diseases caused by a defective immune system are of particular concern among many purebred fanciers.
The immune system is a marvelous defense network of white blood cells, antibodies, and other substances used to fight off infections and reject foreign proteins. It is this ability that causes the body to reject skin grafts, blood transfusions, and organ transplants. Like anything else, the immune system can fail, either by not doing its job or by doing it too well. In all these diseases, the defective immune system fails to protect the body, leaving it vulnerable and open to attack by an opportunistic infection. Autoimmune disease, on the other hand, is a different kind of immune system failure.