The disorder is unique in that it simultaneously affects the nerves, skin, muscles, blood vessels, and bones. RSDS can strike at any age, but is more common between the ages of 40 and 60. It affects both men and women, but is most frequently seen in women. Although it can occur at any age, the number of RSDS cases among adolescents and young adults is increasing. RSDS is often misdiagnosed because it remains poorly understood.
Diagnosis is complicated by the fact that some patients improve without treatment.
Early recognition and prompt treatment provide the greatest opportunity for recovery. RSDS is diagnosed primarily through observation of the symptoms. X-rays may also show changes in the bone. Good progress can be made in treating RSDS if treatment is begun early, ideally within 3 months of the first symptoms. Early treatment often results in remission.