Attenuated Viral or Bacterial Vaccines Microorganisms can be attenuated so that they lose their pathogenicity, but retain their capacity for transient growth with the inoculated host. Genetic engineering is currently being used to selectively remove key genes from the virus that will not affect the transient growth or antigenicity but will eliminate the ability of the microorganism to form revertants. The cultured virus is purified by filtration and lyophilized prior to tableting. Indications Induction of active immunity in healthy U.S. and Canadian military forces particularly during basic training. Also maybe used in closed populations, such as those in chronic-disease hospitals.
Active immunity prevents adenovirus-associated acute respiratory disease.
Mechanism Induces specific protective serum and secretory-intestinal antibodies and CMI response Dosage and Route 1 tablet 2 to 4 weeks before exposure. Oral, do not chew tablets. Adverse Reactions None. Patients undergoing immunosuppressant therapy may not be sufficient responsive. Cultured in egg cultures and purified Indications Induction of active immunity in children and adults.