They found that in cells exposed to Fas, gelsolin was cleaved in vivo in a caspase dependent manner. The expression of the gelsolin fragments also led to the apoptosis of cells. Additional evidence for the role of gelsolin in apoptosis was provided by showing that, as compared with wild-type neutrophis, those from mice lacking gelsolin exhibited a delayed onset of induced apoptosis. Therefore, the authors suggested that cleaved fragments of gelsolin may be implicated in apoptosis. Apoptotic bodies are released from an apoptotic cell.
Arrow points to an apoptotic body.
Ultrastructural feature of apoptotic cells. Arrowheads point to apoptotic cells.