There is no fixed recipe. You might stay put and throw some light around, or run close to the wall for as long as you can, or even head towards what you believe is the center of the mystery. However, no matter where you move when inside the domains of the unknown, pretty soon you clash with another thick wall. It's time to start all over again, and you ponder on all the work it will take to invade the unknown one more time. But after you've been there once, you cannot help trying again.
Curiosity is addictive.
This is the nature of the game. When you understand it, you become humble in face of the infinite unknown, and grateful for the opportunity of playing in its frontier. We came to the Rockefeller University with little more than dreams in our backpacks. Now it is clear why nobody seemed to be ruling our time. Real freedom is necessary to awake the game master in each of us.