Solid tumors will not grow beyond 2 millimeters in diameter without tiny, new blood vessels called capillaries to nourish them. By shutting off growth of these new blood vessels, anti-angiogenic compounds can shrink large tumors in animals down to microscopic size by starving them of essential nutrients and hold them in this dormant state for as long as the compounds are administered. It is also important for formation of egg in the ovary and corpus letuem formation and maintainance. Angiogenesis inhibitors may act as contraceptives by inhibiting placental, endometrial and ovarian angiogenesis. In this case, angiogenesis inhibitors will help to prevent the berserk angiogenesis of the retina, which occurs due to capillary damage by faulty glucose metabolism, but care must be taken to eradicate the root cause of angiogenesis or else hypoxia will cause eye damage.
Angiogenesis is supposed to be helping high rate of cell growth and turnover.
Angiogenesis inhibitors may be useful to prevent this. Angiogenesis inhibitors may also be useful in preventing diseases like atherosclerosis and obesity, but the mechanism of angiogenesis in these pathological states is unclear. About 40 synthetic drugs of the angiogenesis inhibitor class are undergoing clinical trials. Many are undergoing phase three trials. These would counter the uncontrolled angiogenesis and treat many of the above-mentioned pathological condition.