Auer rods may be seen. Auer rods may be seen. CD15 and CD14 are other commonly positive markers on nonlymphoid leukemias. B and T lymphocyte markers should be negative although some myeloid leukemias express CD7. The immunophenotype of AML does not correlate well with the FAB categories.
Chromosomal abnormalities are important diagnostic and prognostic findings.
Abnormalities of chromosome 16 are associated with eosinophilic differentiation. Remember, that the definitive diagnosis of leukemia rests on the finding of increased blasts on bone marrow examination, although it most often presents as blasts in the peripheral blood.