Scopolamine should be used with caution in patients with dysuria, e.g., due to urinary bladder neck obstruction. Caution should be exercised when administering an antiemetic or antimuscarinic drug to patients suspected of having intestinal obstruction, e.g., pyloric stenosis. Scopolamine should be used with caution in the elderly or in individuals with impaired metabolic, liver or kidney functions. Should this occur, scopolamine should be removed at once. In epileptic patients, isolated cases of increased seizure frequency have been reported.
Children are particularly susceptible to the side effects of belladonna alkaloids.
Transderm-V should not be used in children because it is not known whether the amount of scopolamine released could produce serious adverse effects in children. Any parasympatholytic or sympathomimetic agent or barbiturate should be administered with caution to persons wearing scopolamine. Patients should refrain from consuming alcohol while using scopolamine. Alcohol may interfere with the metabolism of the drug and could thus cause plasma levels to become elevated, which could intensify the side effects. Patients should be instructed to remove the disc if they develop difficulty urinating.