A major focus of the class is on learning to parse and discuss papers from the primary literature. 505 Molecular Biology of Prokaryotes Silhavy Advanced-level discussion of the genetics and molecular biology of prokaryotic organisms and their associated bacteriophages. Topics include the genetic code, mutagenesis, mechanisms of DNA replication, recombination, repair and transposition, gene structure and function, and mechanisms of gene regulation, protein synthesis and export. Emphasis is placed on unique features of eukaryotic systems with examples given from higher and lower eukaryotes. Topics include gradients and pattern formation during embryogenesis, receptors and intracellular signaling, cell motility and cell movements, neuronal pathfinding and patterning in the vertebrate neural tube, genetic redundancy and genomic organization.
Classes center on critical reading of the primary literature.
Wang A survey of fundamental principles in neurobiology, followed by organized discussions of selected current research topics. The first half of the course will consist of lectures and a weekly precept on the basis of the action potential, synaptic transmission, circuit-level organization of sensory and motor systems, development, and plasticity. The second half of the course will focus on original scientific literature and student presentations. Readings will center on major problems and current research in neuroscience. The course is designed to explore the molecular events that contribute to the onset and progression of human cancer.