If your specimens are dim and you have to integrate a long time, or you have to capture images quickly, then the noise will be greater in the images. The noisier the image, the less accurate the deconvolution. To minimize camera noise under these circumstances, select a camera with the lowest cooling temperature, the largest well capacity, the lowest dark current and the lowest read noise. It is sometimes difficult to compare cameras on this issue. There is considerable confusion as to the meaning of bit depth and noise.
All chips have a bit depth rating from the manufacturer.
For example the Sony interline and the Kodak KAF chips are both 12 bit chips. However, the effective bit depth of an image from these two chips is quite different. The Sony chip has a well depth of about 18,000 electrons. On the other hand, the Kodak chip has a well depth of 40,000 electrons and a read noise of about 10 electrons. Visually, the images from these two chips are very similar.