The ability to create stains of mice with mutated mtDNA should prove to be extremely important for studying the mechanisms that underlie the transmission and pathogenicity of these disorders. In addition, the study of mice with mitochondrial dysfunction may implicate mitochondrial involvement in disorders of previously unknown origin. Illustration by Bob Crimi. For millennia, humans have been nourished thanks to the physiology of domesticated dairy cattle. Recent research indicates, however, that cows may have far more to contribute to human well-being than milk, butter, and cheese.
Cows are mono-ovulators with a regular ovarian cycle similar to humans .
The OSE normally proliferates after ovulation, and this remodeling process is mitigated by growth factors that are important for the functioning of the ovary. Some researchers believe, however, that this very process gone haywire sets the stage for ovarian cancer. Their aim, Skinner says, was to develop an understanding to provide insight into the potential mechanisms involved in the onset and progression of ovarian cancer. Specifically, TGFa is associated with rapidly growing fetal tissues, neoplastic cells, and normal cells. EGFR is present in normal OSE and in human cancers.