Current research is concerned with the dynamics and kinetics of processes in macromolecular systems.
This work has focused on conformational changes in myoglobin and hemoglobin, and more recently on the process of protein folding in solution. The use of molecular dynamics and related techniques to explicitly simulate the internal dynamics of these systems. The use of matrix methods in the modeling of spectroscopic data sets. Can a two-state MWC allosteric model explain hemoglobin kinetics. Molecular dynamics simulations of heme reorientational motions in myoglobin.