The Pac-Pill at the end can only be got by first jumping onto a ghost. Don't bother with it unless you are already on a ghost. Go straight for 'Break Time'. Round 22 - The mountains. As well as the clouds, you meet a new section - four logs in water that must be jumped onto and crossed.
Careful judgement is needed here.
Get the Pac-Pill afterwards as you'll need it. Time is short so don't stop for anything. Round 23 - The water jets. This gets hard towards the end as there are many ghosts around. Try to stay on the planes.