Studies on these CaM-Ks in the Soderling lab. The regulatory properties of these CaM-kinases are being studied in response to alterations of intracellular calcium in cultured brain cells. Intracellular calcium may also initiate events that lead to long-term memory through new gene expression. Studies in collaboration with Mike Forte are examining developmental and learning effects by selective overexpression of kinase mutants in Drosophila. Science 276, 2042.
Calcium promotes cell survival through CaM-kinase kinase activation of the protein kinase B pathway.
USA 96, 3269-3274. Updated May 9, 2000.