HFCs have zero ODP because they do not contain chlorine. Depletion of this layer by ODS will lead to higher UVB levels, which in turn will cause increased skin cancers and cataracts and potential damage to some marine organisms, plants, and plastics. The science page offers much more detail on the science of ozone depletion. They do not deplete stratospheric ozone , but EPA is concerned about their impact on global warming. The stratosphere extends from about 10km to about 50km in altitude.
Commercial airlines fly in the lower stratosphere.
The stratosphere gets warmer at higher altitudes. In fact, this warming is caused by ozone absorbing ultraviolet radiation. Warm air remains in the upper stratosphere, and cool air remains lower, so there is much less vertical mixing in this region than in the troposphere. The troposphere extends from the surface up to about 10 km in altitude, although this height varies with latitude. Almost all weather takes place in the troposphere.