Deer flies, which commonly bite humans, are smaller with dark bands across the wings and colored eyes similar to those of horse flies. Attack by a few of these persistent flies can make outdoor work and recreation miserable. The numbers of flies and the intensity of their attack vary from year to year. Numerous painful bites from large populations of these flies can reduce milk production from dairy and beef cattle and interfere with grazing of cattle and horses because animals under attack will bunch together. Animals may even injure themselves as they run to escape these flies.
Blood loss can be significant.
In a USDA Bulletin 1218, Webb and Wells estimated that horse flies would consume 1 cc of blood for their meal, and they calculated that 20 to 30 flies feeding for 6 hours would take 20 teaspoons. This would amount to one quart of blood in 10 days. Female horse flies and deer flies are active during the day. These flies apparently are attracted to such things as movement, shiny surfaces, carbon dioxide, and warmth. Once on a host, they use their knife-like mouthparts to slice the skin and feed on the blood pool that is created.