Introduction The ProtFam project is a curated database of homology clusters produced and maintained within the context of the PIR-International Protein Sequence Database. The figure above represents 11 sequences from 5 species which are built from two domains. The bifunctional enzymes are classified into a distinct superfamily as the homology to the monofunctional enzymes does not cover the complete sequence. Homology clusters can be used to predict biological properties of proteins. However, the domain architecture needs to be known to avoid false functional assignment.
Aspartate kinases are homologous to the bifunctional enzymes.
However, not all the biological properties of the bifunctional enzyme are due to the aspartate kinase domain and the protein will have a different cellular role. In the navigation frame you can retrieve families by entry code . Please note that only entries from the PIR-International Protein Sequence Database can be selected as only these are classified in ProtFam. In the navigation frame you can also select by superfamily number , family number , or homology domain number . However, we try to minimize typing of such arbitrary bookkeeping numbers by providing clickable links and number auto-assignment.