Demonstrating that antibody binding is selective to sulfatide and not polyspecific to a wide variety of glycolipid antigens. Clinical correlation with patients having sensory-motor neuropathies. This is especially helpful in patients whose neuropathy would otherwise be labeled as idiopathic. The neuropathy may be either demyelinating or axonal . Some immunomodulating treatments, such as intravenous immunoglobulin or cyclophosphamide, may produce improvement in weakness, sensory loss or gait disability.
Corticosteroids are unlikely to be of benefit, even when neuropathy is demyelinating.