Diagnosis depends on detection of bleeding, family history, and laboratory testing. Hereditary von Willebrand's Disease. In von Willebrand's disease, there is a defect in the body's ability to produce vWf. This results in excessive bleeding from the body cavities, such as the nose, the uterus, the bladder, and the rectum. Most patients with von Willebrand's disease have a history of the disorder in their family.
Diagnosis is made based on patient and family history, physical examination, and laboratory testing.
Treatment depends on the type and severity of the disease. In cases of severe bleeding, transfusions may be necessary. D. Dysfibrinogenemia Fibrinogen is the molecule that will eventually become fibrin, the major blood clotting protein. Fibrinogen is produced in the liver and bone marrow and released into the blood and eventually becomes fibrin. Dysfibrinogenemia is produced by an inherited problem in fibrinogen production.