Before undergoing ICSI, it is important to discover the cause of infertility. A notable proportion of men with infertility have a genetic alteration causing their infertility. This fact is significant because these men are at increased risk for having recurrent miscarriages, children with birth defects and learning disabilities, and sons with infertility. Y-DNA microdeletions, or 3.
Chromosomes are units of genetic information in the cells of the body.
Each cell should contain 46 chromosomes, arranged into 23 pairs. Klinefelter syndrome is characterized by an increased chance for learning disabilities, minor physical differences, and infertility. Most men with Klinefelter syndrome go undetected until trying to conceive children, when an evaluation for infertility is performed. With the assistance of ICSI, men with Klinefelter syndrome are able to have children. Although these men can have healthy children, there is also an increased chance to have a child with a sex chromosome abnormality.