The effects of isradipine are believed to be most pronounced in regions rich in dopamine, which in phase I had been associated with marked reductions in blood supply during cocaine use. This is the first demonstration in humans that any medication can prevent the damaging effects of cocaine on brain blood flow. The results suggest that isradipine may be a useful therapeutic agent for cocaine addicts, many of whom are at high risk of stroke with all its attendant consequences for the individual and the health system. Funding was provided by the Advanced Technology Program of Texas. In 1991, the number of cocaine-related ER incidents began an increasing trend that reached an estimated 142,410 in 1994 from a low of 80,355 in 1990.
Cerebrovascular accidents are a common cause of death among cocaine addicts.