To date, all 2500 DNA samples have been processed ad genetic analyses have begun. The availability of a complete clinical profile on an entire population, combined with modern methods in genetics should make it possible to establish the possible relationship of genetic variation at the human ob and db genes to human obesity. In addition, a highly admixed population provides an opportunity to identify additional loci that affect the control of body weight, as well as the medical problems that are often associated with obesity such as hypertension, diabetes, heart disease. Future studies will also focus on the physiologic effects of leptin. These include studies of leptin's effects on lipid metabolism, glucose metabolism and insulin action.
Available data suggest that neurons in the hypothalamus are a principle target of leptin actin.
Studies to establish the neurotransmitter profile and projection of Ob-Rb positive neurons have begun. Analysis of the electrophysiologic effects of leptin on these cells will proceed simultaneously.