X-rays of the thumbs are often extremely informative. The second most common group of defects, grouped because of their tendency to occur in a variety of combinations and permutations, involves developmental abnormalities of the ear and eye Ear defects tend to be bilateral and fairly symmetrical. These occur among persons affected by thalidomide more often than in the general population. Limb abnormalities are characterized by phocomelia, amelia, clubfeet and supernumerary fingers. Facial abnormalities include microtia, facial palsy, orofacial cleft and microphtalmia.
Cardiac malformations range from ventricular or atrial septal defect to conotruncal defects.
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