Migration, attachment, proliferation, differentiation, matrix synthesis, thus the developing tooth acts as a perfect model for examining repair process'. Migration by chemotaxis of precementoblasts is thought to occur by fibronectin and laminin located on the root aspect of Hertwig's epithelial root sheath. Attachment could be mediated through integrins and or fibronectin.or a whole host of other proteins. Hertwig's epithelial root shealth - derived proteins are required for cementoblast differentiation. I and II, platelet derived growth factor.
Conclusion is that the factors which regulate cementum activity remain ill-defined.