We have independently confirmed Dr. Amagai's findings. The exact mechanism of blister formation subsequent to anitbody binding is not known. The availability of PVA opens doors to better diagnostic and therapeutic measures in the future. PVA could also be used to develop an animal model for PV, allowing the study of PV before, during and after disease initiation. This would allow specific immunotherapies based on interfering with the different stages of an autoimmune reaction.
Continued research is necessary to apply basic scientific findings to therapy and patient care.
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