Houston Colt .45s play their first major league season in the National League. Ken Hubbs sets the major league mark and is the first second baseman with seventy-eight errorless games. The Alou brothers appear together in the same outfield for the first time. The first and last All Hispanic American All-Star game is played. Jim Bunning pitches the first perfect game on Fathers Day.
Baseball approves the first free agent draft.
First domed stadium opens Harris County Domed Stadium, also known as the Houston Astrodome. Mickey Mantle hits the first home run ever in a domed stadium. Rick Monday is the first pick in the first ever free agent draft. Denny McLain sets the major league mark and is the first to strike out the first seven batters he faces. Sandy Koufax is the first and only pitcher with no-hitters in four consecutive years and the fourth is a perfect game .