Unlike breast cancer, which often grows under the influence of estrogen, prostate cancer is not so straightforward. Some prostate cancers will stop growing when estrogen is blocked with the drug tamoxifen, but others will not. And when estrogen is given, these androgen-driven cancers will stop growing. It may, because I3C has other anticancer properties. One of I3C's most important actions is to interfere with cancer cells' ability to grow.
Cancer cells override the checkpoints, and grow at break neck speed.
I3C restores the brakes. By forcing the cancer cells to stop at the checkpoint, the body has an opportunity to destroy deviant cells and stop the growth of cancer. Chemotherapeutic drugs such as doxorubicin work the same way. I3C is also potentially important in restoring communication between testosterone, estrogen and progesterone. This can be critical because these hormones have a direct effect on the growth of prostate cancer cells.