Desktop computers are usually more comfortable to use because their keyboards are larger.
Ergonomically speaking, desktop computers are usually better than laptops because you can better control the height of the monitor and keyboard, thus reducing the chances of eye, back and wrist strain. The monitors are also larger on a desktop computer, of course, which also eases eye strain. The processor speeds on a desktop computer are also much faster for the price you pay. But also note that desk space in the residence halls is limited, and a desktop computer and monitor will take up the majority of your desk. A mini or mid-size tower case is highly recommended, as it will usually sit under or beside your desk fairly easily.