My laboratory pursues two different lines of research, both of them related to T lymphocytes.
Chronic inflammation is a part of pathology of many infectious, autoimmune, neoplastic diseases.
Activated T cells are present in most of the chronic lesions and through their cytokine production they define the character and the outcome of the local inflammatory reactions. In various diseases the blockage or enhancement of local T cells facilitates cure. Infection by Schistosoma, Leishmania and Mycobacterium induce life threatening chronic diseases. Chronic liver granulomas are a common feature in the murine models of these infections. Expression of FcgR is highly regulated during the activation and differentiation of T cells.