There are Ghana Airways flights from Kotoka Airport in Accra to almost every country in West Africa, as well as flights to New York and London. The airport is also served by several major western carriers. Watch your pockets at crowded border posts. The steamer stops at many villages on the way. Ghana's road network is in decent shape, though there are some badly potholed stretches between Kumasi and Tamale, and almost all secondary roads are unsealed.
Car rental is expensive but available in Accra.
Driving is done on the left. Government-run buses connect most major towns and some smaller ones, but their service ain't what it used to be and it's usually better to travel with any of the private bus companies. A comfortable but slow railway system connects Accra, Kumasi and Takoradi in a single-track triangle. Only sleepers need to be booked in advance. Reading Lonely Planet's West Africa and Africa on a shoestring guides provide practical information on travelling in Ghana.