Symptoms of the disease include muscular weakness and spasm. An increase in tendon reflexes and spasticity may precede atrophy in the hands, forearms, and legs. The onset of amyotrophic lateral sclerosis generally begins in middle age and progresses rapidly.
Death usually occurs within two to five years.
The incidence of the disease is greater among males. There is no known cure, although drugs may be used to lessen spasticity or even slow the progression of the disease. Amyotrophic lateral sclerosis is often abbreviated to ALS and is also referred to as Lou Gehrig's disease.