In our laboratory we are performing Busulphan blood determinations and calculate the AUC for pre-bone marrow transplantation in adults and children. It is well known the existence of a direct correlation between the AUC in adults and children and VOD or other toxicity, also, is possible to establish a direct correlation between AUC and engraphtment or rejection of the bone marrow transplantation.
Children has a higher Vd and an increase clearance in comparison to adults.
We found an exponential relation between weight to tmax of Busulphan. The fatter the patient the shorter tmax they have. Thank you for your attention and help. 88, 1-7 Hope this helps.