Numbness, tingling, and burning in the legs and feet. Decreased sex drive. Cessation of menstruation. Anemia, with paleness and fatigue. Muscle and bone pain.
Bones break easily.
Chronic urinary-tract infections. Congenital kidney abnormalities, such as polycystic kidney disease. Kidney damage due to diabetes mellitus. Overdose of many drugs and chemicals, especially phenacetin or streptomycin. Blood-vessel diseases, such as hardening of the arteries in, or leading to, the kidney.