Later refinements in the basic Jewett System added subdivisions to reflect specific conditions within each category. This expanded Jewett-Whitmore system uses an alphanumeric staging system. Found to be well-differentiated. Such cancers usually are left untreated. A2 - Moderately or poorly differentiated.
Cancer cells are present in several locations within the prostate.
B2 - More extensive, involving one or both prostate lobes. C2 - Tumor causes bladder or urethral obstruction. Clinically localized, but showing elevated blood PAP levels. D2 - Distant lymph nodes, bones or organs involved. D3 - Metastatic patients who relapse after therapy.