Knuckle pads may be idiopathic, genetic, acquired as a response to repetitive trauma, or associated with several other acquired conditions. Measurement of prevalence of knuckle pads is difficult because patients are asymptomatic and do not seek medical attention for them. Patients with Dupuytren contracture are 4 times as likely as the general population to have knuckle pads. Little morbidity is associated with knuckle pads. Patients typically are asymptomatic, but some patients experience pain and difficulty with hand functioning, including writing, as a result of their condition.
Cosmetic issues drive most patients to seek attention for knuckle pads.
No racial predilection is associated with knuckle pads. Prevalence of knuckle pads is equal for men and women. Even in the presence of Dupuytren contracture, the prevalence of knuckle pads remains equal. They have been reported in young children who bite and suck their fingers. More commonly, knuckle pads are observed in adults older than 40 years.