Mitotic cells can be identified using a variety of fluorescence markers. Anti-mitotic drugs such as paclitaxel and vinblastine are used to treat various types of cancer. The Mitotic Index Assay is useful as an HCS tool for identification of novel anti-mitotic compounds, and also as a means for diagnosing and characterizing cancerous cells. Skin fibroblasts from Alzheimer patients also show reduced proliferative capacity and mitotic index, broadening the applicability of the assay. Images taken from the ArrayScan II System of MDCK cells.
Blue channel indicates nuclei, pink channel indicates mitotic bodies.
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