The Effect of Anemia on Myocardial Dysfunction in Sepsis. Our preclinical studies have also made original observations regarding tissue oxygenation in sepsis. Sepsis depresses the metabolic oxygen reserve of the coronary circulation in mature sheep. Hyperdynamic sepsis depresses circulatory compensation to normovolemic anemia in conscious rats. Structure-function relationships in the septic rat heart.
Blood substitutes offer unique opportunities to the delivery of oxygen in critically ill patients.
We also found that DCLHb achieved this action, in part, by facilitating an improved capacity of the tissues to extract 02, through a direct effect on the microcirculation. Current experiments have been designed to dissect out the mechanisms for the improvements in microcirculatory blood flow found during the infusion of this blood substitute. Lam C, Tyml K, Martin C, Sibbald W. Microvascular perfusion is impaired in a rat model of normotensive sepsis. Transfusing red blood cells stored in citrate phosphate dextrose adenine-1 for 28 days fails to improve tissue oxygenation in rats. Diaspirin crosslinked hemoglobin improves systemic oxygen uptake in oxygen supply-dependent septic rats.