A hypercoagulable state is one in which due to an inherited or acquired disorder there is an increased propensity to form thrombosis. This state is manifested clinically by either an increase in number of thromboses, thrombosis at an early age, a familial tendency toward thrombosis, and thrombosis at unusual sites. Early reports indicates it might be involve in arterial disease also. Mechanism of action unsure.
Deficiencies primarily causes venous thrombosis.
Protein S -a cofactor for Protein C. Exists in bound and unbound form. Primarily cause venous thrombosis but has been associated with CVA's in young women. Antithrombin - inhibits activated clotting factors. Primarily venous thrombosis. It usually NOT associated with heparin resistance.