The levels of diastereocontrol were recorded prior to any purification. Differences in the copper salts varied from initial oxidation state to various changes in the electronic and steric environment. A systematic survey of alkenes and diazoesters for comparative analysis will be performed once a suitable catalyst has been selected. Results Shown below in Table 1 are the results of the study. Each entry was performed in triplicate in order to ensure reproducibility.
All data represent the average of two runs.
Each entry was performed in triplicate. Determined by 1 H NMR spectroscopy prior to purification. A more reactive, and thus less selective, metal carbene is produced as electron removing groups are employed. Efforts to improve the diastereocontrol of intermolecular cyclopropanation reactions are underway and will be reported in due course. Recent Advances in Asymmetric Metal Carbene Transformations.