Why You Should Take this Course Sequential design has become more popular in clinical trials.
Brownian motion is a powerful tool for interim analyses and it is easy to learn.
This course provides an overview of sequential methods used in clinical trial data monitoring. Many two-sample statistics in clinical trials, when computed over time, approximate The Brownian motion process. The instructors will give a simple introduction to the Brownian motion process and apply it to the evaluation of conditional power and sequential analysis of clincal trial data. The lecture includes a brief introduction to the group sequential methods proposed by Pocock, O'Brien-Fleming, and their extensions through the spending functions. The second half of the course presents a heuristic introduction to survival data analysis and martingales.