It can occasionally cause liver damage, so it is important to have liver functions tested regularly. Dantrolene sodium is less likely than the benzodiazepams to cause drowsiness or confusion, but it may cause general weakness. Liver damage can be caused by Dantrolene, so it is usually not prescribed unless other drug treatments have not been useful. It is very important to have periodic checking of liver enzymes and functions while on this medication. Some doctors have been treating HSP patients with Botox injections to reduce the spasticity.
Botulinum toxin is injected directly into the muscle to be treated, which weakens it.
Range of motion exercises can then be used to help lengthen the muscles. The treatment must be repeated periodically. It is an experimental drug that has not been approved by the FDA, and therefore will probably not be covered by medical insurance. It has been used with some success in treatment of Multiple Sclerosis related fatigue, muscle weakness, and heat sensitivity. At least one person with HSP has been taking it and reports improved strength.