At this time, I do not believe that EVA testing will add anything to the response rates using standard protocols. I have seen no published evidence that it does. Nor can I find any published evidence that an EVA recommendation has resulted in an increase in anyone's survival. Rational Therapeutics' Web site lists about 75 manuscripts and abstracts written or co-authored by Dr. Nagourney. However, none of these appears to demonstrate that the test is clinically valuable or cost-effective.
Differences exist in the responses of different tumors to particular drugs.
The EVA test gives little guidance about dose. The test is quite expensive and, in my opinion, is not worth the expense or the trouble. Rational Therapeutics Web site, accessed Feb 14, 2000. Rational Therapeutics Web site, accessed Feb 14, 2000. Rational Therapeutics Web site, accessed Feb 14, 2000.