Alkalinization of the urine may help to minimize the risk of sulfamethoxazole crystal formation. In patients with impaired renal function, both trimethoprim and sulfamethoxazole may be removed from the blood by dialysis. Therapy should be continued for at least 5 days in acute infections, or until the patient is asymptomatic for at least 48 hours. If the drug has to be given for protracted periods of time, consideration should be given to dosage reduction. The sterility of the urine should be re-evaluated 2 to 4 weeks after cessation of therapy.
Adequate dosage is important in chest infections in order to maintain high sputum concentrations.
It has also been suggested to continue the drug for 2 days following eradication of purulent sputum. Bottles of 50 and 250.