Another major interest in the lab is a class of protein phosphatases that are essential for regulating a cell's passage through the cell cycle. We have determined the structures of the catalytic domain of human Cdc25A, and a homologous yeast phosphatase of yet unknown function. Unexpectedly, these proteins have a fold different from other types of protein tyrosine phosphatases. Lastly, we are closely collaborating with Drs. We have recently determined the structure of a novel ribosome-binding protein and an RNA methylase.
Current work is directed towards a chaperone protein, which is regulated by cell oxidation levels.
Structure of Hsp15 reveals a novel RNA binding motif. EMBO Journal , in press. Structure and function of FtsJ-a novel methyltransferase under heat shock control.