The Duck Creek and Rocky Run watershed lies in west-central Columbia County.
Agriculture predominates, with dairying and cash cropping the primary activities.
This watershed is in the glaciated portion of the basin. Stream gradients are generally not as steep in this watershed as in those within the unglaciated region. There are some large wetland complexes, particularly near Duck Creek and its tributaries. Springvale and Mud Lake State Wildlife Areas and Rocky Run State Fisheries Area are in this watershed. Three minor municipal wastewater facilities discharge in the watershed.