The disease is the result of a loss in the balance that normally exists between bone resorption and deposition. Such loss results in microarchitectural defects which in turn cause low bone mass that can ultimately increase the risk of fracture.
BMD measurement is the best predictor currently available to assess the risk of fracture.
HRT imparts to its users some health benefits beyond those related to osteoporosis yet not all women can, or are willing to, use it. Bisphosphonates and calcitonin are compounds that are useful for the treatment of osteoporosis. Calcium, vitamin D and weight bearing exercise help promote bone mineral competency but alone cannot prevent osteoporosis.