These lesions are very transient, therefore ulcers, erosions and crusts are more likely to be seen. The oral cavity is usually the first site that is affected. Ulcers involving nailbeds with sloughing and inflammation of the nails may occur. Affected areas of the skin are also the axillae and the groin. Animals may be depressed, febrile and ill.
Diagnosis is made by cytology and histopathology.
Acantholytic cells are seen on cytology. On microscopic examination of the skin, suprabasal clefts are noted. Gold salts are sometimes used. This disease is fatal without therapy. This is the most commonly seen form of pemphigus in domestic animals.