If you need this application, please click here to download it. Tablets has been shown to be efficacious and well tolerated. In clinical studies in more than 3,400 hypertensive patients in the U.S. and abroad, perindopril was proven to provide continuous 24-hour blood pressure control throughout the entire dosing interval with a single daily dose. In a pivotal clinical study, perindopril demonstrated approximately equivalent blood pressure reduction at 6 and 24 hours after administration.
ACE inhibitors continue to be studied in a variety of areas.
ACE inhibitors are recommended as first-line therapy for hypertension in certain patient populations, because of their safety and efficacy. Most recently, the Sixth Report of the Joint National Committee on Prevention, Detection, Evaluation, and Treatment of High Blood Pressure has recommended ACE inhibitors as first-line therapy for the diabetic, hypertensive patient. Blocking the production of angiotensin II results in arterial vasodilation and an accompanying reduction in blood pressure. ACE inhibitors account for 37.5 percent of the total antihypertensive prescriptions in the U.S. as of 1999. The usual maintenance dose range is 4 to 8 mg, administered as a single daily dose.