Abnormalities of the immune system are inconstant, providing no clues to the cause and pathogenesis of Beh et s disease, which remain unknown. The severity of the syndrome abates with time. The life expectancy seems to be normal, except in the cases with neurologic complications. The only serious complication is blindness. Young male patients are at increased risk for ocular complications and require aggressive medical management.
Arthritis responds to analgesics and rest.
Mucous membrane involvement may respond to topical corticosteroids in the form of paste or mouthwash. Immunosuppressants are considered to be the main line of treatment for eye involvement. Azathioprine has shown to maintain visual acuity and to prevent the emergence of new eye disease. Cyclosporin A is an effective alternative to azathioprine. However, nephrotoxicity, the rather regular relapses with cessation of therapy and the high cost of the drug often limit its use.