In addition, the models are able to answer clinically important questions not addressable by standard analyses. Various MPCP models have been developed, and applied to studies in neurology, public health, traffic safety, and hypertension prevention. Current work includes optimal design for change-point problems and applications to Alzheimer's disease. Consideration of the optimal number of subjects required is an essential step in the planning of virtually every experiment in medicine. Novel methods have been developed for sample size determination for experiments giving rise to binomial, normal, and differences between two binomial or normal data.
Current research investigates more complex univariate and multivariate situations. .
New biostatistical methods cannot reach their full potential without the distribution of the software necessary for their implementation. User-friendly programs have been created for all of the above methodologies, and have been made available to other researchers through the internet. In addition to the above methodologic research activities, I also serve as the collaborating biostatistician on many projects in various areas of medical research. Among others, I am currently participating in projects investigating osteoporosis , gastroenterological disorders, lupus nephritis, and cardiovascular diseases.