When using these medications concurrently with nefazodone an initial dosage reduction of the benzodiazepine is needed. Nefazodone is also contraindicated with the non-sedating antihistamines terfenadine and astemizole due to inhibition of their metabolism and the possible resulting fatalities. Numerous other drug interactions have been reported with nefazodone. When these two medications are used together, routine monitoring of digoxin levels is warranted. Depending on the dose prescribed, these agents are approximately equivalent price.
All antidepressants are equally effective in treating depression.
Nefazodone may not be drugs of choice in patients with cardiovascular problems. More studies need to be conducted to look at the side effect profile for nefazodone. Dosage titration may need to be done slowly so as to avoid potential side effects. Nefazodone is more expensive compared to generically prescribed TCAs. Nefazodone's places in therapy for the treatment of depression need to be defined.