All of these drugs are only effective against bacteria with cell walls, as they target cell wall biosynthesis. Clavulanic acid is a potent inactivator of beta-lactamases. All of the above have similar activies. Tazobactam also inhibits beta-lactamases. They are not readily absorbed into eukaryotic cells.
Bacteria possess porins that allow access of penicillins to the target enzymes.
Eukaryotic organisms do not possess porins. Eukaryotes neither possess a peptidoglycan cell wall nor the supporting enzymes to produce it. These bacterial enzymes are the target for the penicillins. Any penicillins that are absorbed into mammalian tissue are rapidly inactivated by endogenous, cytoplasmic peptidases. None of the above.