Drug of choice for visceral lesions. Interactions Oral hypoglycemics and insulin dose adjustment required Oral anticoagulant effectiveness may decrease. Increases metabolism of isoniazid and salicylates. Barbiturates, phenytoin, and rifampin may cause decreased effects due to increased hepatic metabolism Pregnancy C - Safety for use during pregnancy has not been established. Precautions Hypertension, renal disease, GI ulcer, diabetes mellitus, osteoporosis, hypothyroidism, cirrhosis, seizures, CHF, psychosis.
Complications are rare and are dependent on site of involvement and associated conditions.
Ocular involvement may progress to ocular hemorrhage, glaucoma, or retinal detachment. CNS involvement is a very rare complication. In the absence of therapeutic intervention, skin lesions flatten with time. Both cutaneous and extracutaneous lesions involute spontaneously in 3-6 years. Hypopigmentation, mild atrophy, or anetoderma may persist.