Males must take precautions too Males should not father children while they are on methotrexate or for 12 months afterwards because of its effects on sperm. If, and when, to do a liver biopsy should be discussed with the physician. Lung disease Methotrexate can rarely cause a lung reaction similar to pneumonia. Should you develop such symptoms, notify your doctor promptly. A vitamin supplement, folic acid, is thought to reduce some of the side effects of methotrexate without preventing its good effect on the skin.
Dermatologists often recommend one tablet on several days each week.