Through the use of finite element techniques, we are modeling the influence of loading conditions and bone geometry on the progression of this disease. In our computer simulations, we predict changes in cartilage thickness and bone density as the bone develops and ages. The simulations begin very early in development, when the bone end is chiefly cartilaginous. Within the model, cartilage is assumed to mature based on a combination of mechanical and genetic factors. Mature cartilage is subsequently replaced by bone.
Bone density is increased in areas of high stress and decreased in areas of low stress.
These computer models are run repeatedly to simulate the passage of time and aging. Our preliminary models predict early development and endochondral ossification of long bones very well. These models are now being applied over longer time periods to predict the influence of bone geometry and loading conditions on the progression of osteoarthritis. Tendons and Ligaments Leong, Carter Tendons and ligaments are susceptible to a variety of traumatic and overuse injuries. In severe cases, these injuries can impair the musculoskeletal function and mobility of a patient.