The problem emerges when the Type As are thwarted - they do not achieve success in life. This results in a very high level of anger and frustration. These people are at risk. Stress and Depression Depression represents an extreme form of malaise, lasting for months, without respite. It is disabling, and completely disrupts the individual.
Controllable stress has no such effect.
The importance here is the perception of control by the subject, the major psychological aspect of the stressor. Stress, depression and immune responses are closely related. The activated immune system initiates release of stress hormones. Additional stress hormones are released, and stress-related brain systems are activated. These symptoms are the same when a person feels depression.