Thus, the effect is likely due to both the parent compound and the metabolite. Food does not affect either the rate or extent of absorption. The ability to convert risperidone to 9-hydroxyrisperidone is subject to genetic variation. A low percentage of Asians have the ability to metabolize the drug.
Clearance is decreased in geriatric clients and in clients with hepatic and renal impairment.
Use with caution in clients who will be exposed to extreme heat or when taken with other CNS drugs or alcohol. Greater risk of orthostatic hypotension, aspiration pneumonia, and toxic effects in geriatric clients with impaired renal function. The effectiveness of risperidone for more than 6-8 weeks has not been studied. Safety and effectiveness have not been established for children. Prolongation of the QT interval that might lead to torsades de pointes .