Heat or moisture may cause the medicine to break down. Do not keep outdated medicine or medicine no longer needed. Be sure that any discarded medicine is out of the reach of children. It is very important that your doctor check your progress at regular visits to make sure that this medicine is working properly and to check for unwanted effects. Do not drink alcohol while using this medicine .
Alcohol can increase the chance of liver problems.
Some patients who take methotrexate may become more sensitive to sunlight than they are normally. When you first begin taking methotrexate, avoid too much sun and do not use a sunlamp until you see how you react to the sun, especially if you tend to burn easily. In case of a severe burn, check with your doctor. This is especially important if you are taking this medicine for psoriasis because sunlight can make the psoriasis worse. These medicines may increase the effects of methotrexate, which could be harmful.