Male reproductive toxins can in some cases lead to sterility. A chemical with an LD 50 of 200 mg less per kg of body weight when administered by continuous contact for 24 hours to certain test populations. Laboratory workers must complete a Particularly Hazardous Substance Use Approval form . The area where the PHS will be used is posted as a designated area. The laboratory worker proceeds with the experiment, following the practices outlined in the Particularly Hazardous Substance Use Approval form, as well as the appropriate work practices included in the remainder of the Safe Work Practices and Procedures section of this manual.
All work is conducted within the Designated Area.
The laboratory worker decontaminates all equipment and disposes of waste promptly, as outlined in the Particularly Hazardous Substance Use Approval form. There should be no eating, drinking, smoking, chewing of gum or tobacco, application of cosmetics or storage of utensils, food or food containers in laboratory areas where PHS are used or stored. All personnel should wash their hands and arms immediately after the completion of any procedure in which a PHS has been used and when they leave the laboratory. Each procedure should be conducted with the minimum amount of the substance, consistent with the requirements of the work. The laboratory worker should keep records of the amounts of each highly hazardous material used, the dates of use and the names of the users.