Prednisone is a corticosteroid, the most potent class of anti-inflammatory medication in use. The use of prednisone is hoped to slow the rate of progression of Alzheimer's disease. Approximately 150 patients will be enrolled at 20 sites across the country. Participation involves 15 outpatient clinic visits over a 68 week period. Patients take study medication in varying doses along with calcium and vitamin B supplements.
All participants receive careful medical monitoring, including assessment of memory and behavior.
Recent research has shown a beneficial effect of estrogen on brain cells and brain chemicals. The presence of this hormone has demonstrated improvement in cognitive function in women with Alzheimer's disease. Approximately 120 patients will be enrolled at 26 sites across the country. Participation involves 6 outpatient clinic visits over a 64 week period. These visits include a brief physical exam, blood test, and tests of memory and behavior.