Much of the work is expected to involve collaborations between chemists and biochemists and cell and molecular biologists. The results will be relevant to understanding the mechanisms of metal toxicity and the basic cellular roles underlying the nutritional requirement for essential metals. It is expected that this research will also contribute to the identification of new targets for drug discovery, diagnostics, and future therapeutic approaches, although drug development, per se, is not a focus of the program at this time. Applications that propose to advance the technologies associated with such phenotyping also are welcome. Since its formation in 1997, the committee has played an active role as an advocate for the zebrafish as an important model for development and disease research.
Applications ranging from basic research to clinical diagnosis and treatment are of interest.
Multidisciplinary research teams and collaborative alliances are encouraged but not required. Emphasis is on the development of innovative approaches to adherence and behavior change, especially models of interventions to improve adherence. Approaches based on basic behavioral principles such as cognition, emotion, decision-making, motivation, social interaction, and cultural context are particularly encouraged. A well-articulated and empirically based conceptual framework is essential in applications solicited under this announcement. The AHRQ is seeking applications for research grants that will examine the effect of working conditions on health care workers' ability to provide safe, high-quality care.