The microscopy of affected bone usually shows a proliferative bone reaction to the spread of tumour over the bone trabeculae. This results in the visible diffuse sclerosis of the affected bone. Often close inspection will reveal an area of bone destruction. The prostate is the commonest source of sclerotic bone metastasis. Its frequency and tendancy to newbone formation both contribute.
Breast is the more common sclerotic metastasis in females.
Most tumours can form sclerotic deposits at some stage, even myeloma. Usually, the mucinous tumours are more likely than other primaries. The most likely area of bone involvement is that most vascular portion or the red bone marrow. Experienced viewers say that if you look hard enough, you will see a little bone destruction somewhere, which helps to discriminate bone metastasis from other causes of sclerosis. The present images are not detailed enough for this analysis.