John Wright, dean of the School of Medicine and Biomedical Sciences, said this research exists on the cutting edge of the application of molecular biology to human disease. Although a genetic linkage has been presumed to underlie bipolar disease in many individuals, this research promises to reveal the molecular basis of that linkage, and may well lead to important diagnostic and therapeutic advances. We are all very proud of their accomplishments. Carlos Pato, principal investigator on this research project and associate dean for clinical affairs in the medical school, said bipolar disorder affects about .7 percent of the worldwide population, with a large percentage having a possible genetic component. Though it is likely that nongenetic factors play an important role in the expression of these illnesses, a significant portion or risk must be genetic.
Bipolar disorder is characterized by dramatic mood swings between mania and depression.
The mood swings develop and subside spontaneously and may be cyclic, with sufferers remaining manic or depressive for months. Persons in the manic phase of the disorder can be psychotic, are easily distracted, experience exaggerated feelings of well being, exhibit inflated self-esteem and may indulge extravagantly in irrational activities. In the depressive phase, persons experience inertia, loss of self-esteem, withdrawal, sadness and may be suicidal. Present treatments for bipolar disorder focus on managing these symptoms. The Patos said they hope that uncovering the genetic etiology of these disorders will be an important step in developing improved treatments and, possibly, specific cures.