There is even a link to AutoPilot , which will produce a set of instructions for driving to Vestal from anywhere in the United States and Canada. Remembering this will save you a lot of grief at the end of a long trip. A request to AutoPilot for a routing from the Newark Airport to Vestal generated a pretty accurate itinerary, except it took us just past the University. The local directions web page will fix the oversight. The Greyhound or Shortline bus terminals are in downtown Binghamton.
Cabs usually meet the incoming buses except very late at night.
Once you have escaped from the airport ring roads the drive from Newark is about 3 hours. If you can, arrive a day early and recuperate in New York. If you do this, the preferred arrival airport is probably Kennedy. Allow about one and a half hours to mid-town. A company called Olympic Limousine may be a good deal for several people traveling together to Manhattan.