Thresholds for these latter complications are outside of the scope of this document. Systemic Toxicity Systemic toxicity of the chemotherapy agent can be rated according to the standard criteria outlined by the Eastern Cooperative Oncology Group . Systemic toxicity should not exceed that of IV therapy with the same agent. If thresholds for complications or toxicity are exceeded, a review should be conducted. The response to treatment varies with the initial grade and type of tumor.
Complete response is unusual.
Efficacy of the therapy should be judged in comparison with standard treatment as it evolves over time. Bibliography Lee YY, Wallace S, Dimery I, Goepfert H. Intraarterial chemotherapy of head and neck tumors. Comparison of intra-arterial and intravenous infusion of cisplatin for head and neck squamous cell carcinoma in a modified rat model. Phase I study of highly selective supradose cisplatin infusions for advanced head and neck cancer. Woessner W. A pilot study of intraarterial chemotherapy with cisplatin in locally advanced head and neck cancers.