He began his political career as an assistant state attorney general, then as Columbus city attorney. He served in the Ohio House of Representatives for six years before being elected to Congress in 1966. During his tenure, he became ranking Republican on the House Committee on Banking, Finance and Urban Affairs and was a member of the Joint Economic Committee and the House Committee on Veterans' Affairs. As senior member of the Ohio congressional delegation, Wylie was a vital contact in Washington and an ambassador for Ohio State. He was instrumental in obtaining the Veterans Affairs Outpatient Clinic on campus as well as crucial funding for The Ohio State University Cancer Research Center, which paved the way for the Arthur G. James Cancer Hospital and Research Institute.
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