Rehearse your answers. Don't be defensive. Think beforehand about why you left certain jobs to start new ones. Frame positive answers. No one wants to hire someone who has left their last three jobs because they hated all three bosses.
Chances are, they'll hate the next one, too.
Do some soul searching, and be ready to talk about where you'd like to take your career. That's certain to come up in one way or another. There are no right or wrong answers. You'll want to have some, though, that indicate you're personally motivated to do quality work in the service of this fine newspaper. Either path works.