All should be taken with extreme care. Phenothiazines and other antidopaminergic agents that depress the central nervous system are the most potent drugs to treat nausea and vomiting, but are not useful in treating motion sickness. Antihistamines, which have a depressant effect on the neural pathways, may also be useful in treating nausea, including that associated with motion sickness.
Anticholinergics relieve nausea by inhibiting nerve impulse transmissions.
They are especially useful in the relief of nausea and vomiting associated with vertigo and motion sickness. Anticholinergic drugs should not be given to people suffering from glaucoma or to people with a tendency toward urine retention problems.