Quantitatively the major enzymes of glutamine metabolism in the body are glutaminase and glutamine synthetase. The principal fuels of the colonic mucosa utilizes glutamine and butyrate. We will obtain cDNA and genomic probes for chicken muscle glutaminase for future studies of species differences in glutamine metabolism. Rat adipose tissue amino acid metabolism in vivo as assessed by microdialysis and arteriovenous techniques. Asence from liver but presence of high activity in pectoralis muscle.
Dietary glutamine suppresses endogenous glutamine turnover in the rat.
Glutamine and glutamate metabolism across the liver sinusoid.