However, if the resuscitation takes place after sustained period of hemorrhagic shock, then resuscitation with the first generation blood substitutes may result in ishemic-reperfusion injuries and causing more harm than without such resuscitation. This would also apply to other ischemic conditions including reperfusion in stroke and other situations. However, it will be disastrous to think of the first generation modified hemoglobin blood substitutes as an universal blood substitute for use in all conditions. This further points to the need for the research and development of new generations of modified hemoglobin blood substitutes. Karger, Basel, Switzerland.
Blood substitutes in development.
Red Blood Cell Substitutes.