Don't take it as a tonic or mood booster. It does not prevent any known disorder. Contrary to rumor, SAM-e will not repair the liver damage caused by heavy drinking. Side effects have been reported, including stomach upset and other gastrointestinal problems. If you are suffering from depression, seek medical advice before trying this supplement.
Depression is a treatable illness, requiring professional care.
Don't try it on your own or combine it with antidepressant drugs. If you have joint pain, talk to your doctor before taking SAM-e. Make sure it's actually arthritis that's causing the pain. If you do decide to try it, make certain your diet is rich in fruits and vegetables, and take a multivitamin. How the FDA can allow it to be sold as such remains a mystery.