The research of this laboratory is concerned with peptide-based antimicrobial host defense systems.
Antimicrobial peptides are a prevalent, but only recently recognized, component of host defense.
These peptides are found in phagocytic cells and in mucosal tissues such as the trachea and the small intestine. Research in this laboratory is concentrating on the molecular biology and the mechanisms which control the expression of both classes of these peptides, especially under conditions of injury, stress and infection. This research is being carried out in both in vitro cell culture systems and in small animal models. A complete understanding of these peptides will enable us to better understand host defense, and may lead to the development of novel therapeutic agents. We are also studying antimicrobial peptides expressed in marine species.