The drug decreases sinus rate, increases PR and QT intervals, results in development of U waves, and changes T-wave contour. No significant changes are seen in left ventricular ejection fraction after PO use.
Absorption is slow and variable but food increases the rate and extent of absorption.
Several days up to 1-3 weeks. Drug may accumulate in the liver, lung, spleen, and adipose tissue. Effects may persist for several weeks or months after therapy is terminated. Neither amiodarone nor its metabolite, desethylamiodarone, is dialyzable. The proposed new names are inamrinone to replace amrinone and camiodarone to replace amiodarone.