Some other sex variable must be involved in the triggering of blindness. The data on treatment with hydroxycobalamin are poor and, although no proper clinical trials have been done, general experience of treatment with hydroxycobalamin and steroids is disappointing. Even in Glasgow, where this treatment was first suggested, it is now no longer used. There is a blurred overlap with nutritional and tobacco alcohol amblyopia, but this entity has virtually disappeared. Patients are probably wise not to change their diets excessively to avoid cyanide as virtually all food contains some cyanide.
Almonds are realistically the only food to avoid.
Ortiz et al. It may be that ECG abnormalities are confined to some families. Neurological abnormalities are common. LHON is a disease we understand. Molecular abnormalities suggest that the use of coenzymes or free radical scavengers may help.