Give daily for each day of ondansetron. Begin 30 minutes before chemotherapy. Give daily for each day of prochlorperazine. Begin 30 minutes before chemotherapy. Infuse IV dose over 15 to 30 minutes.
Dexamethasone improves efficacy.
Avoid only if contraindicated or otherwise prohibited by protocol. The use of lorazepam 12 to 48 hours prior to admission may prove helpful, but is poorly studied. Rescue Antiemetics for PRN Use 1. Antiemetics for Nausea and Vomiting Associated with Radiation Therapy 1. The degree of emetogenic risk associated with radiation therapy is generally related to the site, dose, dose rate, field size, and recent or concurrent chemotherapy.