Since the source of the moisture that feeds the build-ups comes from the east, sites on the west side of the Puno are more likely to be free of interference. From the flow of the weather and sources of moisture, the west side appears more promising but in any case the difference is small. Travel on the altiplano is not difficult though access is not convenient to most of the eclipse track. To reach the center line on the altiplano is probably easier from Oruro, though the distance is in the neighborhood of 150 kilometers. This is adventure traveling, and the 3800 meter altitude should not be taken lightly.
Acclimatization is required.
Eclipse observers should plan on several days at altitude beforehand and not a quick visit from sea level. It is probably a good idea to limit the tasks you want to do during the 3 minutes of totality because of the chance of altitude-induced befuddlement. As the Moon's shadow leaves the altiplano, the weather becomes increasingly cloudy as the path descends to lower pressures on the Atlantic side of the Andes. However this site could have been sunnier than usual over those two years. Cloud cover is extremely variable within this region, depending on the exposure of each valley to the east and south winds that bring the moisture.