Meningitis Rare Produce a typical chronic meningitis picture. Multifocal tenosynovitis and arthritis that mimics gonococcal infection or seronegative spondyloarthropathy Widespread visceral involvement associated with fungemia. It is available at the IDSA website . Due to the temperature sensitivity of the fungus, local application of hyperthermia can be used for the treatment of cutaneous lesions. Prognosis of disseminated disease is grave.
Antibacterial antibiotics are useful when secondary bacterial infections occur.
The pattern of inflammation is characteristically well circumscribed and granulomatous with central areas of acute suppuration. In the skin, this pattern is similar to that seen in blastomycosis and coccidioidomycosis. Demonstration of the organism in tissue may be difficult because the fungi are not numerous. It may be necessary to search through many serial sections before observing the organism. The yeasts are not encapsulated.