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Basophils are responsible for the symptoms of allergy.
Despite similarities, basophils appear to be a distinct cell type from mast cells . They are capable of synthesizing many of the same mediators as mast cells . Basophils, like other inflammatory granulocytes , enter tissues only when they are recruited into inflammatory sites. Preformed granule-associated mediators such as histamine , serotonin , bradykinin , heparin , cytokines . Newly-generated mediators , prostaglandins and leukotrienes , made from arachidonic acid in surrounding tissues.