Many individuals in the general population may have MSI, but the key is how to pick them up. We stained for MSH2 and MLH1 proteins, which are mismatch repair gene products. Those tumors with high MSI displayed loss of one or the other DNA mismatch repair proteins, indicating this was a good pretest for loss of DNA mismatch repair genes. The scientists also examined four other markers involved in cell cycle regulation. For a cell to grow, it has to pass through a cycle of particular biochemical steps.
Cancer is characterized by the loss of control of such cell growth mechanisms.
The researchers found associations with the absence or presence of MSI with other cell cycle proteins, suggesting that deficiencies in DNA repair may play a role in cell cycle biology. Characterizing the cell cycle pathways controlling growth might help improve the understanding of cancer. These could provide information allowing us to identify targets for new therapeutic approaches to colorectal cancer. The Kimmel Cancer Center Web site, its content and programs, is provided for informational and educational purposes only and is not intended as medical advice, nor is it intended to create any physician-patient relationship. Please remember that this information should not substitute for a visit or consultation with a health care provider.