There are minimal effects on respiration, pulse and blood pressure, unless the overdosage is extreme. Patients have recovered from dosages of up to 60 mg without special treatment. When the effects of the drug overdosage begin to wear off, the patient exhibits some jitteriness and over stimulation. Gastric lavage may be beneficial if performed soon after ingestion of clonazepam. CNS stimulants and vasopressors may be used if necessary.
Dialysis appears to be of no value.
Whenever possible, the daily dose should be divided into 3 equal doses. If doses are not equally divided, the larger dose should be given before retiring. Dosage may be increased in increments of 0.5 to 1 mg every 3 days until seizures are adequately controlled or until adverse effects preclude any further increase. Maintenance dosage must be individualized for each patient depending upon response. The use of multiple anticonvulsants may result in an increase of depressant adverse effects.