This protein interacts with actin filaments and is a putative protein tyrosine phosphatase. Mutational analysis of PTEN in CD kindreds identified germline mutations in four of five families. Mammographic image of breast cancer. Breast cancer appears as a dense area within the mammogram. Gross appearance of breast cancer.
Breast cancer appears as a stellate, hard tumor which infiltrates the surrounding breast tissue.
The mutations found in PTEN in human tumor cell lines and primary tumors. Submitted , 1997. Germline mutations of the PTEN gene in Cowden disease, an inherited breast and thyroid cancer syndrome.