Contraindications In patients with known hypersensitivity to the drug. Fluvoxamine should not be administered together with MAO inhibitors. At least 2 weeks should elapse after discontinuation of MAO inhibitor therapy before fluvoxamine treatment is initiated. MAO inhibitors should not be introduced within 2 weeks of cessation of therapy with fluvoxamine. Convulsions have been reported rarely during fluvoxamine administration.
Caution is recommended when the drug is administered to patients with a history of seizures.
If seizures occur during fluvoxamine administration, the drug should be discontinued. Treatment with fluvoxamine has been rarely associated with increases in hepatic enzymes, usually accompanied by symptoms. Fluvoxamine administration should be discontinued in such cases. Fluvoxamine may potentiate the effects of alcohol and increase the level of psychomotor impairment. Sedation may occur in some patients.