In pemphigus foliaceus there are IgG antibodies that bind to the cell surfaces of epidermis of the skin. As a result, patients develop superficial cutaneous erosions.
Diagnosis is made by biopsying the skin.
The biopsy specimens show deposition of antibodies on the cell surfaces of the epidermis or epithelium by using specialized immunofluorescence techniques performed in our Dermatoimmunology Laboratory. Our laboratory also uses immunofluorescence techniques to detect antibodies in the blood. The titer of these antibodies may be helpful in evaluating the severity of the disease as well as disease course and response to therapy. Aggressive immunosuppressive therapies are indicated to control the disease.