Combining these drugs can change the amount of each drug in your bloodstream and cause an under- or overdose. Drugs to watch out for include several antihistamines, sedatives, and anti-fungal drugs. Make sure that your doctor knows about ALL drugs you are taking. Blood levels of delavirdine may be decreased by ddI , antacids, rifabutin, and rifampin. Be sure to take delavirdine at least one hour apart from ddI or antacids.
Delavirdine makes the liver work slower.
This increases the blood levels of most protease inhibitors. There is very little specific information about combining delavirdine with protease inhibitors.