This server uses the pfscan program to search a single sequence against currently available profile databases.
All searchable databases contain generalized profiles.
If this is not the native format of the database, the entries have been converted to the generalized profile format. The process of profile construction and iterative refinement is described on this poster presented on the 1995 ISMB meeting in Cambridge. We are now also offering searches using our large collection of pre-release profiles. You can browse the available profiles and check the status of the documentation project in this list . Pfam Pfam is a collection of protein motifs and families initially compiled by Erik Sonnhammer and Sean Eddy .