Therefore, it is now recommended that if you drink three or more alcohol-containing drinks per day, you need to consult your physician before taking any OTC pain medication. Experts state that the liver damage and acetaminophen toxicity occur because of two reasons. First, alcohol shifts the metabolism of acetaminophen from a non-toxic pathway to a toxic pathway resulting in more toxins than the body can eliminate. Second, alcohol-associated malnutrition results in decreased amounts of enzymes needed to neutralize these toxins. Without these enzymes, the toxins pile up in the liver leading to cell death and ultimately liver necrosis.
Alcohol stimulates the release of gastric acid in the stomach and is irritating to the stomach.
So the next time you have a hangover and begin to reach for a pain reliever, remember the possible side-effects that you could get from taking OTC pain medications. The latest advertisements of OTC pain relievers may not help in choosing the right drug for you. Always remember that your safest bet is to ask questions and consult your physician or pharmacist before taking any new medications, OTC or prescription. This is especially true if you consume alcohol on a regular basis. The Center for Proper Medication Use.