Iron therapy is contraindicated in the presence of hemochromatosis, hemosiderosis, hemolytic anemia. If necessary, dosage should be reduced or calcium therapy discontinued. High vitamin D intake should be avoided during calcium therapy unless especially indicated. Certain dietary substances interfere with the absorption of calcium. Administration of corticosteroids may interfere with calcium absorption.
Calcium compounds reduce blood concentrations of oral tetracyclines.
Concomitant use should be avoided or doses of the drugs should not be taken within 3 hours of each other. Oral preparations containing iron may aggravate existing peptic ulcer, regional enteritis and ulcerative colitis. Occasional constipation may occur with high calcium carbonate intake. Rarely, in iron sensitive individuals, mild gastrointestinal upset may occur. Suitable for sodium restricted diets.