Well, imagine that as a constant dynamic in a relationship, an uneasy, fearful feeling. It's enough to erode any relationship. It's almost like developing an allergy to each other, and can in fact give real physical symptoms. Hypochondria is part of this dynamic, the ultimate cop out, the 'escape into sickness' syndrome and you wonder who is the perpetrator and who is the victim. You never really know except that someone is carrying the load.
Adjustment implies change and too many adjustments imply complete change.
A few quincunxes might be fruitful for individual personal change to accommodate the needs of another, but too many are too demanding. The Quintile is the creative, willing risk taking, playful and joyful dimension of the relationship. If you find these there is joy to be found in the relationship. It might be through children, through work or just simply enjoyment of each other and a common involvement with arts, music etc. These people are prepared to take a few chances, and will tend to lay it all on the line to each other so there is indwelling honesty.