It does not induce sex-linked recessive lethal mutations or nondisjunction in Drosophila melanogaster . Amitrole induced mutations at two loci in one mammalian cell line. Amitrole does not induce unscheduled DNA synthesis in hepatocytes of rats exposed in vivo . No aneuploidy or chromosomal aberration is found in cultured human lymphocytes. Micronuclei are not induced in mouse bone marrow.
Cell transformation is induced in mammalian cells.
A commercial preparation of amitrole induces chromosomal abnormalities in plants. 5.3 Human data Two cytogenetic studies of occupational exposure to a number of herbicides, including amitrole, were available. A possible increase in the frequency of chromosomal aberrations was seen in one study, and an increased frequency of sister chromatid exchanges occurred in one group of workers in the other. The role of amitrole itself cannot be evaluated from these studies. No data were available to evaluate the reproductive effects or prenatal toxicity of amitrole to humans.