No specific pathologic changes are found. During acute attacks, polymorphonuclear leukocytosis is frequently, but not invariably, found. Results of other laboratory tests are normal. Despite the severity of symptoms during acute attacks, most patients recover swiftly and remain free of illness until their next attack. Widespread use of prophylactic colchicine has been associated with a dramatic reduction in the incidence of amyloidosis and subsequent renal failure.
Children often require adult dosages to achieve effective prophylaxis.
Colchicine does not add to the increased risk of infertility and miscarriage among affected women, nor does it increase the number of teratogenic events when taken during pregnancy. Narcotics are sometimes needed for pain relief but should be administered prudently to avoid drug addiction. All rights reserved.