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Provides a platform of ideas from which new directions for research in behavioral etiology of substance abuse can be developed, addressing genetic bases, neurophysiological correlates, and neurochemical factors underlying drug abuse risk or resistance. Examines important demographic distinctions among subgroups. Includes data on grade at first use, intensity of drug use, students attitudes and beliefs about various types of drug use, and students' perceptions of relevant aspects of the social environment. Discusses prevalence and effect of drug abuse among secondary school students. Presents the results of the 1977 through 1994 followup surveys of graduating classes of 1976 through 1994.