Sometimes asking a naive question can tumble a once hallowed theory. Posing a question and using a thought experiment is a very good way to get practice in developing ideas and tracking through a process. A cautionary note, however, is in order. Designing the experiments for efficiency represents an ideal. Any time you are using experimental organisms you must consider whether the question is worth the asking.
Alternative models can reveal interesting results.
When it is necessary to use experimental organisms, it is critical to maximize information. This requires careful planning and consideration of multiple hypotheses. It is critical to have an understanding of the differences between statistical significance and biological significance in designing an experiment. It is also important to know the difference between observation and inference . Always keep in mind that attention to detail and good note taking are essential to design.