FYI Digest Newsletter Back Issues 32. The purpose of this RFA is to stimulate research designed to increase our knowledge base relevant to Fragile X syndrome in these and other research areas by encouraging applications that include, but are not limited to, developmental neurobiology, pathophysiology, genetics, proteinomics, epidemiology, structure-function correlations, and clinical studies that have a direct link to Fragile X syndrome. This RFA focuses on neurobiological and epidemiological studies relevant to understanding the genetic and pathophysiologic basis of Fragile X syndrome.
Animal models are important resources for studying pathology and therapeutic strategies.
Although some animal models have been created, there is still need for models for behavioral screening as well as therapeutic interventions that include suppression of expansions and restoration of expression. The anticipated date of award is April 1, 2001.