Thus, it may selectively prevent hypersynchronization of epileptiform burst firing and propagation of seizure activity. 1 hr during fasting. Metabolized in the liver. Excreted through the urine as metabolites and unchanged drug. Reduce dosage in clients with impaired renal function.
Clearance is increased in children.
Half-life is prolonged in the elderly. Use with caution during lactation. Safety and efficacy have not been determined in children less than 16 years of age. Pharyngitis, rhinitis, sinusitis, increased cough. Asthenia, headache, infection, pain, anorexia, diplopia, coordination difficulties.