A decrease in body weight gain, erythrocyte count, and hemoglobin level was observed at 500 ppm. At 5000 ppm, cyclic decreases in food consumption accompanied by violent motor reactions were observed. Decreased body weight gain, increased mortality, decreased hemoglobin, decreased hematocrit and thrombocyte count, and increased cholesterol were observed at the high dose. An uncertainty factor of 100 has been used to account for the inter- and intraspecies differences in the extrapolation from laboratory animals to humans. The principal study appears to be of good quality, and therefore, is given a high rating.
Additional studies are of medium to high quality.
Therefore, the data base is given a high confidence. High confidence in the RfD follows. Not available at this time. MRID No. 00048631, 00060230. Write to FOI, EPA, Washington, DC 20460.