The disseminated disease has a significant death rate. The course may be rapid for immunosuppressed patients. Erythema nodosum usually occurs in association with specific infections, inflammatory conditions, or medications. It consists of painful, hot, red skin lumps, usually over the shins. People with erythema nodosum should be evaluated for other disease processes.
Coccidioidomycosis is most commonly a lung infection, but it can also infect the skin.
Cutaneous coccidioidomycosis on the forehead is pictured here. This occurs more frequently in warmer climates, including California and the Southwestern United States. This person has erythema nodosum nodules on the feet. The feet are red and painful. This disorder is associated with rheumatic disease, but may also be caused by drugs or infections.