The mechanism by which they are related to uncontrolled angiogenesis and use of angiogenesis inhibitor drug to cure them is described in short. Applications of angiogenesis inhibitors in human diseases. In cancer, the cells lose the normal mitotic control and start proliferating at an uncontrolled rate to form a tumor. The existing blood supply to the tumor tissue is not able to provide enough nutrients to the proliferating tumor. Tumors must build new blood vessels from pre-existing ones under influence of various angiogenesis factors to enhance the delivery of vital nutrients that allow them to grow and spread.
Angiogenesis is also necessary for the metastasis of tumors.
Solid tumors will not grow beyond 2 millimeters in diameter without tiny, new blood vessels called capillaries to nourish them. By shutting off growth of these new blood vessels, anti-angiogenic compounds can shrink large tumors in animals down to microscopic size by starving them of essential nutrients and hold them in this dormant state for as long as the compounds are administered. It is also important for formation of egg in the ovary and corpus letuem formation and maintainance. Angiogenesis inhibitors may act as contraceptives by inhibiting placental, endometrial and ovarian angiogenesis. In this case, angiogenesis inhibitors will help to prevent the berserk angiogenesis of the retina, which occurs due to capillary damage by faulty glucose metabolism, but care must be taken to eradicate the root cause of angiogenesis or else hypoxia will cause eye damage.