The infection rate is higher in poorer socio-economic groups where exposure to infection occurs earlier in life. The Epstein-Barr virus is the cause of the condition. The disease occurs in most parts of the world and is well recognized in all developed countries. Cases are usually sporadic, but prolonged localized epidemics occur, mostly in schools and institutions. The disease probably spreads by droplet infection.
All ages are susceptible, but the disease is more common in young adults.
Symptoms may continue for 2-3 weeks. Most cases remain at home, with symptomatic treatment and bed rest during the febrile stage. Antibiotics have no place in treatment and Ampicillin is particularly to be avoided. Nothing can be done to prevent the spread of the disease in the community. Annually, more than 10 million Americans are infected and 100,000 women are left sterile.