A comprehensive orthopaedic oncology unit is involved in both clinical and basic science research concerned with sarcomas and other neoplasms. Participation in multi-institutional cancer protocols are underway for osteosarcoma and Ewing's sarcoma.
Clinical trials involving biopsy and limb-sparing surgeries are ongoing.
The treatment of metastatic bone cancer from carcinomas and melanomas are other areas of focus. Intense research into the molecular biology of musculosketal neoplasia is the primary focus of the unit. The presence or absence of microsatellite instability and telomerase activity in sarcomas are currently an active area of investigation. Selected Publications Martin SS, Hurt G, Hedges LK, Butler MG, Schwartz HS Microsatellite Instability in Sarcomas. Publication Rates of Abstracts Presented at the 1993 Annual Academy Meeting.