The facility has a capacity of approximately 200 mice. All activities within the facility are overseen by the University s Laboratory Animal Veterinarians and the Purdue Animal Care and Use Committee. Services Provided Services provided by The Drug Development Shared Resource include growth inhibition and cytotoxicity assays in cell culture, tumor cell implantation, treatment, and monitoring tumor growth necessary to test the efficacy of antitumor agents. Euthanasia, post-mortem evaluation, and routine tissue processing are currently available. Studies assessing the gross toxicity of new compounds are performed in BDF1 mice to define a maximum tolerated dose for therapeutic evaluation.
Consultation is provided regarding suitability of particular models and experimental design.
Veterinary pathology and pharmacokinetics expertise is provided by Drs. In lieu of a chargeback for the xenograft experiments, Cancer Center investigators will be expected to pay for the purchase and per diem costs of their mice. Standard rates will be developed for in vivo services that will apply to non-Cancer Center members.