The goal of this program is to accelerate the integration of the vast amount of genomic sequence and expression data being generated into functional and clinically relevant information that will yield insights into mechanisms of human disease. Collaborative proposals linking geneticists working on a particular model system and clinicians investigating therapeutic approaches to related clinical phenotypes are encouraged. Computational methods development. Awards are intended to stimulate the development of new theoretical and mathematical models for extracting meaningful information from genomic sequence and expression data, as well as for synthesizing the structural and functional data coming from different gene expression networks and model systems. Collaborative proposals encompassing experimental validation of theoretical models are encouraged.
Awards are open to individual candidates or small groups of collaborators.
Candidates must have a Ph.D., M.D., or D.V.M. degree and hold a tenure-track faculty appointment at the assistant, associate, or full professor level. Proposals should focus on the modeling of complex multigenic traits, rather than on determining the functions of individual genes. Awards are not intended to support ongoing research. The application deadline for the 2000 award series is December 1, 1999. Higher priority will be given to the overall innovation and promise of the candidate's work than to contributions to any of these specific topics.