Establish a target price that you want to sell your stock at. When it reaches that price, sell half your holdings. Especially if a stock doubles over time, then you sell off half of it. Once you've sold, don't rush out to re-invest in other stocks. Sometimes when people sell they feel that they have to buy right away.
Brokers earn commissions each time a stock is traded, but the fees are lower and up-front.
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