Low MLT is somehow connected to migraines, but, I suggest, the levels of DHEA have to be examined to fully explain it. Women produce more DHEA from birth than men. This extra DHEA should have most effect on migraines prior to the onset of interfering sex hormones, before puberty. This use of DHEA by these tissues should reduce the availability of DHEA, i.e., increased testosterone should decrease migraines. This can be seen in the fact that, following puberty, women still have more migraines and that whites have more migraines than blacks.
Blacks produce more testosterone than whites.
The prevalence of migraines also follows this pattern. Females, whites, and individuals residing in rural counties were more likely to suffer migraine headache than their respective comparison groups. I have read that headaches occur when blood vessels in the brain constrict. Since I have suggested elsewhere that I think DHEA stimulates constriction of blood vessels and increases blood pressure, I suggest increased DHEA causes the constriction of blood vessels in migraine headaches. Constricting blood vessels and reduced blood flow is characteristic in migraines.