Doses should be titrated to lowest effective level. If bleeding occurs before the end of this regimen, therapy is discontinued and resumed on the 5th day of bleeding. The same schedule may be repeated if bleeding does not occur at the end of the treatment period. The number of treatment periods depends from responsiveness of the endometrium. If bleeding occurs before the end of the 10 days rest period, a 20 day estrogen-progestogen cyclic regimen is recommended.
Adverse effects are common in such large doses.
Dose adjustment to therapeutic response is important. For temporary relief of local discomfort, 1.25 mg to 2.5 mg 3 times daily. Effectiveness can be judged by symptomatic response to therapy and by phosphatase determinations. Bottles of 100 and 1 000. Bottles of 100 and 1 000.