My postdoctoral work at the Graduate Hospital and University of Pennsylvania School of Medicine, in Philadelphia, focused on the effects of elevated membrane cholesterol on ion channel function in vascular smooth muscle, using whole-cell voltage clamp techniques. I became an Assistant Professor of Medicine and Physiology at Wayne State University School of Medicine, Detroit, MI, in 1993 where I built my research program as described above. Drug-induced and other interventions. Regulation of calcium channel expression in neonatal myocytes by catecholamines. Troglitazone attenuates high glucose-induced abnormalities in relaxation and intracellular calcium in rat ventricular myocytes.
Diabetes rapidly induces contractile dysfunction in isolated ventricular myocytes.
Low insulin and high glucose induce abnormal relaxation in cultured adult rat ventricular myocytes. Abnormalities of Cardiovascular Calcium Metabolism Associated with Daibetes Mellitus and Metabolic Hypertension.