Mon Oct 30 Voet , Chapter 23, pp. A second pathway starts from progesterone and skips 17 -hydroxylation.
Aldosterone spontaneously converts to the hemiacetal form, which is active.
The activity of cortisol may be modulated by reversible conversion to the less active form cortisone . The aldosterone pathway is confined to the outer layer of adrenal cortex, while glucocorticoids are produced by cells in the inner layers. Small amounts of testosterone and estradiol are produced in the adrenal as well. This is exacerbated if the activity of C-21 hydroxylase is weak, and may result in unusually high testosterone levels in females who have this deficiency. Corticosteroids like other steroids are carried around the body in the blood by a specific carrier globulin.