Brain requires direct use of glucose for energy.
See fig 1 hepatic steatosis as a result of fatty mobilization. Arginin increases it the most. Histidine increases it the least. Brain edema-flattening of gyri Summary Diabetes is mainly a metabolic disease of improper handling by the cell of metabolic fuels. See example of pyelonephritis in a diabetic patient Fig 2 weight loss Ketosis Large and small vessel disease.