Determinations were also performed for 22 normal controls and 96 neurology patients. The proportion of osteonecrosis patients with elevated anti-PNM antibody levels was greater than that found in systemic demyelinating disorders. These may play a role in continued pain or the development of demyelinating diseases. J. Bouquot , R. McMahon. It is associated with deep bone pain, false negative radiographs, intramedullary hypertension, ischemia, infarction, and coagulopathies.
Bone remains predominantly viable.
Bone pathology experts in the field were consulted. The most consistent features were sinusoidal dilation and reticular fatty degeneration. BMES is histopathologically identical to early or mild forms of ischemic osteonecrosis. It may not be a separate disease entity. Conversely, many osteonecrosis cases may be misdiagnosed.