Mortality in adults is usually very low. In pigs, the main sign is lameness. There is also fever and loss of appetite. Vesicles form along the top of the foot, on the heels and between the claws. Vesicles may also be form on the snout, but tend to rupture quickly.
Abortion is common.
Mortality in piglets can be high In sheep and goats, the disease is usually milder with fewer lesions. Affected sheep are depressed and reluctant to stand. Some animals may get a sudden lameness. Vesicles form around the top of the foot and between the claws. Lesions may develop on the tongue and dental pad, but can be hard to detect.