Antacids interfere with many drugs. Staggering the antacid away from medications is always preferable but again is a nuisance and hard to comply with long-term. Antacids are useful for the temporary relief of occasional indigestion and heartburn. Frequent, daily or nightly symptoms usually mean a more serious problem. Antacids by themselves do not correct these problems.
Calcium containing antacids can also treat calcium deficiency and prevent osteoporosis.
The medications that are now available to treat acid problems are generally superior to antacids. It is best to take them with food as the buffering effect in the stomach lasts for 2 to 3 hours. If you have symptoms at night, take the antacids before retiring. However, it is more important not to eat within 2 hours of sleep as eating often promotes reflux of acid into the esophagus. Keep all medications away from children.