View femur radiographs. View tibia radiographs. These radiographs demonstrate epiphyseal and metaphyseal flaring at the ends of the femur and tibia. Lytic lesions are noted throughout the long bones. These bony abnormalities are not primarily due to the Alagille syndrome.
Cholestasis usually develops in the first few months of life.
Episodes of jaundice, are interspersed with periods of anicteric remission. These features are usually not fully apparent until 5-10 years of age. The most common cardiovascular abnormality is isolated and nonprogressive pulmonary stenosis of the peripheral pulmonary vascular tree. Embryotoxin, a pigmentary material, accumulates in the inner aspects of the cornea near its junction with the iris. It is best observed with a slit lamp examination.