Existing theoretical methods are inadequate for most practical applications. We are developing improved computational tools for this purpose. We are focussing on the use of methods from statistical physics to dissect the behavior of these complex systems according to size scale. Computer algorithms are being developed, using simple model systems, towards the goal of eventual application to physiologically important problems. Additional projects focus on the development of more efficient methods for molecular dynamics simulations.
C hanges in a simple conformational probability landscape with decreasing temperature.
Our current work, using a variety of recombinant DNA, biochemical and cell biology techniques, focusses on the examination of this hypothesis and the investigation of the potential role of pp60c-src in other phases of the cell cycle.