If INR value outside therapeutic range and no signs or symptoms of thromboembolic complications or bleeding, have INR done again in 3 days. Monitor regularly, about once every 4-6 weeks when anticoagulation level is stable. Therapy Bleeding is the most important complication of anticoagulant therapy. Drug interactions are the commonest cause of significant change in the INR value. Patients should be informed not to change any medication without a physician's or pharmacist's advice.
Adequate monitoring is the key to a successful and safe warfarin therapy.
Please refer to the TIG brochure on warfarin therapy. Smith P, et al. Antiplatelet Trialists' Collaboration. Fifth ACCP Consensus Conference on Antithrombotic Therapy.