Enamel hypoplasia has also been reported.
All tetracyclines form a stable calcium complex in any bone-forming tissue.
This reaction was shown to be reversible when the drug was discontinued. Evidence of embryotoxicity has also been noted in animals treated early in pregnancy. If any tetracycline is used during pregnancy or if the patient becomes pregnant while taking this drug , the patient should be apprised of the potential hazard to the fetus. Studies to date indicate that this does not occur with the use of doxycycline in patients with impaired renal function. Photosensitivity manifested by an exaggerated sunburn reaction has been observed in some individuals taking tetracyclines.