The transdermal patches, vaginal rings and estradiol creams provide pre-menopausal levels of estradiol. If you desire a natural estrogen that is the least likely to cause cancer then estriol may be right. Tri-Est contains mostly estriol. However a dose high enough to prevent hot flashes causes nausea. So its mostly, but not totally, estriol.
All costs are approximate.
Its intent is solely informational and educational. The information is not a substitute for talking with your health professional.