The only way humans can hold out is to try to make the game as long as possible. We all go to cash machine. The car you drive was made by a computer controlled by an automated factory. And the car itself has computer chips that govern injection and anti-lock brakes, among other things. If you wear pacemaker, you have computer chip inside you.
Chess is such a game although the number of possible scenarios is quite big.
It is to be expected if not now then at some point in the future that a computer will be able to handle these moves better or equally well than a human. Computers are superior in their number crunching abilities. But computers will never be able to handle information in a human way - meaning intuitively learning the proper context and meaning of a word for example. There are attempts to accomplish intuitive learning made with neural nets. But these nets are still designed by humans and therefore are limited by human creativity.