A monthly urinalysis and CBC count are recommended, and penicillamine should not be used in those with renal disease. Parenteral gold salts. Gold sodium thiomalate and aurothioglucose. Maintenance therapy is 25 to 50 mg weekly. If there is no improvement with a cumulative dose of 1 or 2 g or if toxicity develops, therapy should be discontinued.
Diarrhea is a common side effect.
Monthly urinalysis and CBC counts should be performed. Treatment can sometimes be temporarily halted and then restarted at lower doses, and side effects may not recur, but you need to let the rash clear because it can lead to an exfoliative dermatitis. Usually require only cessation of treatment until the urine clears. Thrombocytopenia, pancytopenia, agranulocytosis, and aplastic anemia. Usually responds to stopping drug.