Dear All, Various biomodulators have been extensively tested for decades to enhance cytotoxicity of 5-FU and other fluoropyrimidines. Results as reported in the literature showed that deoxyinosine significantly mediates the in vitro sensitivity of various human carcinoma lines to 5-FU, which has been correlated by our own results. Surprisingly, deoxyinosine doesn't seem to have been tested in vivo, despite the fact that this modulator is known to be potent since the earlies 70's.
Any information is much welcome.