Neuropharmacology Neuroreceptor Visualization and Quantification Research is focused on regional brain differences in neuroreceptor regulatory mechanisms both in normal and pathological conditions. To this end, receptor autoradiographic techniques, in situ hybridization and quantitative immunohistochemical procedures are used in histologically preserved brain sections. Neurochemical systems currently studied in these preparations include dopamine, norepinephrine, serotonin, acetylcholine, GABA, glutamate, and thyroid hormones. Selected Publications D'Almeida V, Hip lide DC, Lobo LL, de Oliveira AC, Nobrega JN and Tufik S. Melatonin treatment does not prevent decreases in brain glutathione levels induced by sleep deprivation.
Acute stress increases thyroid hormone levels in rat brain.
A paradoxical effect. Sensitization to ethanol's stimulant effect is associated with region-specific increases in brain D2 receptor binding. Heterogeneous effects of REM sleep deprivation on binding to alpha and beta adrenergic receptor subtypes in rat brain.