The two drugs often are compared to each other because they produce similar mood-altering effects and both have a high potential for abuse and dependence. Methamphetamine is man-made.
Cocaine is plant-derived.
Short-term effects also can include increased activity, respiration, and wakefulness, and decreased appetite. Effects of chronic abuse can include dependence and possible stroke. These strokes involved sudden dramatic reductions in blood flow to areas of the brain, resulting in neurological symptoms, such as paralysis, loss of speech, and dementia. Chronic abuse also can lead to paranoia, hallucinations, mood disturbances, and violence. Drug craving, paranoia, and depression can occur in addicted individuals who try to stop using either methamphetamine or cocaine.