However, the exact role that NK cells play in surveillance for tumor cells and in the immune response to tumor cells is poorly understood. The mechanisms by which NK cells recognize abnormal cells are not yet defined. This study aims to identify specific molecules on tumor cells that are recognized by a specific NK cell receptor. These studies will further our understanding of how NK cells are able to recognize abnormal cells and distinguish them from normal cells. This mechanism is important to understand the role of NK cells in response to tumors and to develop methods to alter the NK cell response against tumors.
Cancer occurs when cell growth can no longer be regulated.
Understanding how cancer cells proliferate underlies one of the keys to a cure. This research proposal examines some of the molecules which are involved in regulation of cell growth in the hope of using these molecules to return to a cancer cell to a normal cell. Specifically, lung cancer and colon cancer cells in culture are being studied to understand mechanisms of regulation of cell proliferation. Our laboratory has focused a novel molecule which may be able to control cell growth in cancer cells. We hope that this work leads to novel therapies whereby molecules such as these may reclaim growth regulation.