We have recently developed a procedure in which the antigen used is so highly reactive that a chemical reaction occures in the antibody combining site during immunization. The organophosphonate recruited chemical potential from the immune response that resembled the way these compounds recruit the catalytic power of serine hydrolyses. Reactive immunization can augment traditional immunization and enhance the scope of catalytic antibody chemistry. The inhibitors are novel, pentavalent, distorted, square pyramidal rhenium chelates of adenosine. We think these compounds are close transition-state mimics in the specific hydrolysis of phosphodiester bonds of RNA because they are potent inhibitors of the reaction.
Cocaine is a powerful reinforcer that has become a popular drug of abuse.
It has a variety of pharmacologic effects on the CNS, the cardiovascular system, body temperature, the sympathetic nervous system, and nerve conduction. We are involved in a multifaceted immunochemical and molecular biological approach to the treatment of pharmacologic effects of cocaine. Our plan focuses on antibody technology. In this regard, we are developing aspects of the chemistry, immunology, and molecular biology required to generate and use antibodies to alleviate the toxic effects of cocaine use and addiction. Our work in this area has been to apply a multifaceted approach for the investigation of liquid-phase chemistry.