I am also involved in research activities as they relate to cardio-respiratory disease in persons with a range of congenital cardiac defects. Owing to the diversity of my academic involvement I have a variety of research interests and am involved in several ongoing projects. The majority of these projects are clinical in nature but some do involve laboratory work. At present I have no funding support for a fellow, but moneys are available for the materials requirement for each project. Involves measuring oxygen delivery, consumption and estimates of tissue oxygenation before and following propofol administration and again after paralysis.
Blood transfusion leads to an inflammatory response in patients undergoing routine surgery.
Evaluates the hypothesis that RBC's may stimulate or contribute to a proinflammatory response in the recipient. Cytokine levels in the blood and before and after transfusion in the recipient will be measured. Comparison between old and new RBC's will be made. Obstructive sleep apnea is associated with increased platelet aggregability and leukocyte activation. The remainder of my activities center on patients with congenital heart disease.