The ideal sample for a histomorphometric analysis of bone is a horizontal transiliac crest core biopsy. This is a relatively simple and painless procedure which may be performed in an outpatient clinic.
Complications are minimal.
The patient will be required to spend only a morning in the clinic. Patients are typically double-labeled with tetracycline prior to the biopsy to allow for calculation of kinetic indices of bone turnover. Manual trochars are preferred to electric drills because there is less tissue damage and artifact. If a core biopsy cannot be obtained, a histomorphometric analysis can be performed on a Jamshidi needle bone biopsy specimen. In addition, bone from any location may be used for analysis.