1985-1991 Scientific Member, Basel Institute for Immunology, Basel, Switzerland. In relation to B cell memory we are assessing the relative efficiency of various B cell subsets in memory function, the requirements for germinal centre formation and comparing the role of somatic hypermutation and receptor editing in affinity maturation.
Antibody responses to most protein antigens requires the collaboration between B cells and T cells.
As signals are passing in both directions, there are also consequences for the T cell from this interaction. We observe that B cells when acting as APC tend to induce Th2 differentiation. Representative publications van Essen D, Kikutani H and Gray D . Somatic mutation of Ig V genes in vitro. Stockinger B, Zal T, Zal A and Gray D .