Retinal detachments are common. Primary uveal melanoma is usually unifocal, mushroom shaped, bulky, slow growing, and often ruptures through Bruch's membrane. Anterior uveal metastases are infrequent. Present with decreased acuity and pain. The most common signs are anterior uveitis and red eye.
Ciliary metastases cause shallow anterior chamber, subluxated lens, cataract, spontaneous hyphema.
Secondary tumors arise from direct extension from adjacent structures such as the globe, nasal cavity, and sinuses. Retinal metastases are rare and cause vitreous seeding, can be confused with retinitis. Usually present with uveal metastases and often with brain metastases. Vitreous metastases occur with metastatic melanoma and present with floaters. Painless nodule is most common symptom.