Just press this button. The movie clip shows the signal transduction from nerve to muscle cell and the effects of botulinum toxin. The neuronal signal is transmitted from the nerve to the muscle cell at the synapse. Upon binding of the transmitter to the receptor, the receptor causes the muscle cell to contract. The muscle relaxes.
Botulinum toxin is internalized into the neurons and binds to the vesicle membranes.
There it cleaves proteins involved in the release of transmitter rendering the vesicles inactive. Transmitter is no longer released in response to a neuronal signal. The muscles are paralyzed.