Events have been reported primarily in the elderly on concurrent beta blocker therapy.
Caution is advised when combining mibefradil with beta blockers.
This combination should be avoided in the elderly when pretreatment sinus rate is below 55 bpm. This enzyme system is also responsible for lovastatin metabolism, thus the coadministration of mibefradil with either of these two drugs is contraindicated. Mibefradil is currently not on the KUMC formulary. 200 mg tablets McNeil Topiramate, a sulfamated monosaccharide, differs structurally from other carbonic anhydrase inhibitors or sulfonamide derivative. Topiramate is indicated as adjunctive therapy for the treatment of adults with partial onset seizures.