Currently, studies are in progress of both fine and ultrafine environmental particles and the inflammatory responses resulting from their inhalation. These are assessed using cell and molecular biologic approaches as well as cardiac and pulmonary mechanical measurements. The overall hypothesis is being tested in his laboratory. Pathology of Pulmonary Disease.
Chronic bronchitis alters the pattern of aerosol desposition in the lung.
Pierce LM, Alessandrini F, Godleski JJ, Paulauskis JD . Vanadium-induced chemokine mRNA expression and pulmonary inflammation. Inflammation, chemokine expression, and death in monocrotaline-treated rats following fuel oil fly ash inhalation. Godleski JJ, Sioutas C , Katler M, and Koutrakis P . Death from inhalation of concentrated ambient air particles in animal models of pulmonary disease.