Ultrastructure and force generation in motor proteins of the myosin and kinesin families. Structure and function of DNA motors. Investigating how enzymes utilize transition metals as catalytic centers. Of particular interest is determining the structure and function of biological metal clusters that act to carry out complex oxidation or reduction chemistry. Intracellular water's role in maintenance of macromolecular structure and membrane integrity.
Current work is on stabilization of mammalian cells during freeze-drying.
The first such cells, human platelets, have been successfully freeze-dried and clinical testing is in progress.