The disease course proceeds through three stages.
Adults are more likely to manifest symptoms of neuroberreliosis than are children.
Immune complexes can be recognized by their distinctive staining pattern on zone electrophoresis. B cells in the CNS may give rise to a clonal proliferation of immunoglobulins within the CSF which will appear as a distinct, restricted band in the gamma region of the zone electrophoresis gel. The immune complexes are indicated by arrows. Neuroimaging studies may demonstrate discrete, hyperintense, deep white matter of periventricular lesion best visualized on proton density and T2 weighted images. Belman, AL, Iyer, M, Coyle, PK, Dattwyler, R. Neurologic manifestations in children with North American Lyme disease.