Loss of heterozygosity was not found. This analysis for genetic instability revealed a tumor with the RER phenotype. Figure 2 . Microsatellite instability in tumor. In each marker, lane 1 shows the pattern from normal leukocyte of this patient and lane 2 shows the pattern from the breast cancer.
Arrows indicate the location of the altered-length alleles.
Figure 3 . SSCP analysis of the p53 gene. Mutation was seen in exon 4 of the DNA from the breast cancer, indicated by an arrow. Figure 4 . Immunohistochemistry with DO7, P53 antibody.