The answer is no. The solutions are relatively simple, and do not require the wholesale abandonment of graphic intensive pages. Keep layouts simple. Avoid side by side presentations. Unless otherwise instructed to do so, screen access technology presents information one entire line at a time, reading across.
Columnar information can be very confusing when encountered unexpectedly.
Adjacent hypertext links should be separated with a space or comma. If two adjacent links are separated only by a carriage return, some screen access programs will incorrectly treat this as a single link and thereby provide the user with inaccurate information. When using an image as a hypertext link, be sure to use a separate text file to give a description or transcript of the image. If an image map is present on your web page, provide an alternate means for selecting the items contained within the map, placing them directly above or below the image map. Be sure to include instructions for the user.