There are crowded, two dimensional sheets of cells with rosette-like formation in the groups. Single cells are present. Cell nuclei are hyperchromatic and most have multiple nucleoli. They are frequently associated with a background of squamous epithelial dysplasia. Endometrial adenocarcinomas usually exfoliate small, inconspicuous groups of glandular cells which tend to form three-dimensional clusters.
Cells are smaller and rounder than endocervical adenocarcinomas with finer chromatin pattern.
At postmortem examination, a primary pancreatic adenocarcinoma was present as well as corresponding widely disseminated metastatic disease. Apart from the malignant effusions, tumor involved omentum, peritoneal, pleural and pericardial surfaces, kidneys, spleen, adrenal glands, vertebral bodies and numerous lymph nodes. The uterine cervix was not grossly or microscopically involved. It is possible a small, micrometastates of the cervix was overlooked. This seems more likely considering the relatively sparse cellularity of the neoplastic groups in the cervical smear.