Affected individuals are otherwise normal with no neurological or physical abnormalities.
Many people are affected by scoliosis. Approximately 4 in 1,000 people in the United States have scoliosis, with a curve of at least twenty degrees. As the degree of curvature increases, the frequency of occurrence in the general population decreases. A survey of patients with scoliosis revealed a high prevalence in families of affected individuals, suggesting that genetics may be a factor contributing to the cause of scoliosis. To date, the location of the genes associated with AIS have not been found.