Long term benefits include a small improvement in lung volume and gas diffusion capacity. Since the prognosis of PE with heparin alone is generally favorable no studies, to date, have demonstrated a decreased mortality with thrombolytic agents relative to therapy with heparin alone. For this reason, as in the case of DVT, thrombolytic therapy tends to be reserved for the more severe cases of PE and in subjects without major contraindications to thrombolysis. Absolute suspected aortic dissection acute pericarditis active bleeding any site Relative previous CNS hemorrhage, neoplasm or vascular lesion. Dose Regimens and Monitoring Given below are commonly recommended dose regimens.
Alternate regimens are also available.
In general clots that are susceptible to lysis will improve for up to 18 hours and thrombolytic treatment beyond this is not recommended. Fibrinolytic status should be demonstrable at 4-6 hours. Upon cessation of thrombolytic therapy heparin treatment should be instigated followed by a minimum of three months oral anticoagulation. Venous or Dialysis Catheter Occlusion SK 10,000 or UK 5000 units in 1-2 ml volume into each port of the catheter. Leave for 60-120 min.