Chronic myeloid leukemia is usually a disease of middle age, although it may occur in children and young adults. Peripheral blood in CML shows a moderate marked increase in the white cell count, the majority of the cells being neutrophils, metamyelocytes, and myelocytes. The basophil count is almost invariably increased, and eosinophils may also be increased. The platelet count may be normal or increased.
Anemia is common during the course of the disease.
The marrow in CML is hypercellular with a pronounced myeloid hyperplasia. Hepatomegaly and particularly splenomegaly is present. CML usually presents in an indolent chronic phase, which may last 4-6 years. The accelerated phase is characterized by massive blast and promyelocyte counts, leukocytosis, splenomegaly, along with acquisition of cytogenetic abnormalities in addition to the Ph-1 abnormality. If you need more information, the best place on the internet to search is usually the National Library of Medicine .