Before you edit the registry, make sure you understand how to restore it if a problem occurs.
Access is denied.
You may want to resave the document before continuing. Because IIS caches file handles for performance, some editors are unable to close the file. The editors HomeSite, DreamWeaver, and EditPad are known to generate errors when attempting to overwrite cached files. Microsoft Notepad and Microsoft FrontPage can overwrite cached files without error. To work around this problem, use a different editor or use the Registry Editor to disable caching of file handles.