Medication induced mucosal damage by antineoplastic drugs may cause decreased nutrient absorption. This may cause vitamin B6 deficiency and peripheral neuropathy unless a B6 supplement is also prescribed. Drug decreases the urinary excretion of nutrients . Thiazide diuretics increase excretion of most electrolytes, but decrease excretion of Ca due to renal reabsorption. This effect may cause a hypertensive crisis, which can be fatal.
Caffeine is a stimulant which counteracts the antianxiety effects of tranquilizers.
Diet counteracts the effect of the drug . Drug may be secreted into the saliva . Drug may suppress natural oral bacteria resulting in oral candidiasis . Antibiotics, such as tetracycline, may result in oral yeast overgrowth i.e. candidiasis. Drug may damage rapidly proliferating cells.