The adverse reactions listed below have been observed in controlled and uncontrolled clinical trials in approximately 700 patients who received acyclovir at 300 patients who received daily. These include pulmonary edema with cardiac tamponade, abdominal pain , chest pain , thrombocytosis, leukocytosis, neutrophilia, ischemia of digits, hypokalemia , purpura fulminans, pressure on urination , hemoglobinemia and rigors. Based on clinical practice experience in patients treated with acyclovir sterile powder in the U.S., spontaneously reported adverse events are uncommon.
Data are insufficient to support an estimate of their incidence or to establish causation.
These events may also occur as proof of underlaying disease process. Urinary excretion and renal clearance were correspondingly reduced. The clinical effects of this combination have not been studied.