Molecular Oncology Research CDFD . This work shall help to define new drug targets to combat spread of tumors specifically. It would also help in identifying markers on the tumor cell that could help in the prognosis of the disease. His other interest is in the characterization of the role of the 4 kb upstream sequence element of the polyhedrin gene promoter in hyperactivation of transcription from this promoter. A collaborative study on Familial Hypertrophic Cardiomyopathy has recently been started in collaboration with the Care Hospital and the Osmania University.
Cancer is a multistep process, the genetic basis for which has been only partly elucidated.
There has been a vast improvement in our understanding of the molecular mechanisms regulating the eukaryotic cell cycle. Mutations or abnormal activation of genes involved in regulation of the cell cycle have been discovered in several human cancers. The process of metastasis involves an intricate interplay between cell adhesion, proteolysis, migration and angiogenesis. However, there is little knowledge regarding how these events are coordinately regulated in the tumor cell resulting in metastasis. Given the fact that it is the uncontrolled spread of the tumor to distant organs that usually gives rise to lethality, a study of molecular mechanisms regulating metastasis assumes a lot of significance.