Joel S. Bedford, D. Phil. Dr. Joel S. Bedford Curriculum Vitae Publications Back to RHS Faculty Chromosomal aberrations are principally involved in all of the important biological effects of exposure to ionizing radiations. These include cell killing which underlies effects in normal tissues and tumors after high level exposures administered for cancer treatment, as well as heritable changes in cells which are not killed. Such mutational events can affect the offspring of irradiated parents when they occur in germ cells, or in some cases, cancer if the wrong kind are produced in somatic cells. Research projects in my laboratory involve studies in radiation genetics and cytogenetics, including mechanisms involved in the production of chromosomal aberrations by ionizing radiations and other agents, factors influencing this production, the development of new methodologies for measuring aberrations, the genetic control of radiosensitivity, and radiation induced genomic instability.
Additional studies deal with cell cycle perturbations resulting from radiation exposure.