Selection of biomaterials. Instrumentation for surgical implantation procedures. Project materials drawn from orthopedic devices, soft tissue implants, artificial organs, and dental implants. 12 I.V. Yannas M. Spector H Spring Mechanical forces play a decisive role during development of tissues and organs, during remodeling following injury as well as in normal function. A stress field influences cell function primarily through deformation of the extracellular matrix to which cells are attached.
Deformed cells express different biosynthetic activity relative to undeformed cells.
The unit cell process paradigm together with topics in connective tissue mechanics form the basis for discussions of several topics from cell biology, physiology, and medicine. 12 I.V. Yannas M. Spector H Fall Principles of materials science and cell biology underlying the design of medical implants, artificial organs, and matrices for tissue engineering. Methods for biomaterials surface characterization and analysis of protein adsorption on biomaterials. Molecular and cellular interactions with biomaterials are analyzed in terms of unit cell processes, such as matrix synthesis, degradation, and contraction. Mechanisms underlying wound healing and tissue remodeling following implantation in various organs.