Then sequence what you get. Although not all work. This can have abnormal function. Creates an unusually active Abl protein. 4. gene amplification.
Classic case is methotrexate resistance due to amplification of dihydrofolate reductase gene.
Inherited and spontaneous forms. Inhertied from is autosomal dominant and usually both eyes are affected. Spontaneous is almost always one eye only. Inherited form people start with one copy knocked out. They thus need only a single mutation to get a tumor.