That means that either lots of air must be conducted through the centrifuge, with a certain noise level developing. Or less air is used leading to increased sample temperatures. Depending on the application, increased temperatures can affect the samples negatively, e. g., during enzyme purification. The activity of biologically active molecules can be maintained over a prolonged period of time at low temperatures. And finally, an accompanying effect of refrigerated centrifuges is their low noise level compared to unrefrigerated models, because their rotor chamber can be sealed hermetically.
Centrifugation When getting deeper down to details, there is a lot to bear in mind and to try out.
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