This discrepancy is significant only for those with 1 - 3 ALNs positive. Those who have 4 or more positive have a poor locoregional control regardless of the ECE status. There was no difference in axillary recurrence rates based on ECE status. Survival was trending to be better in those without ECE, though not significantly. Post-mastectomy radiation therapy does seem to have a trend in improving survival and locoregional control in those who have ECE as was known from the prior randomized trials.
Chest wall is the primary site of failure.
ECE is associated with an increase in the rate of arm edema, with or without radiation therapy. The information provided through OncoLink should not be used for diagnosing or treating a health problem or a disease. It is not a substitute for professional care. If you have or suspect you may have a health problem, you should consult your health care provider.