It is the responsibility of the individual patient to be aware of all the things in their environment that cause them problems. There is no known cure for Mastocytosis, so physicians must resort to treating the symptoms. The symptoms of this disease vary widely, and it has been rare to find two patients who have exactly the same set of symptoms. That is the primary reason why Mastocytosis patients often endure years of misdiagnosis before the cause of their symptoms is revealed. Once Mastocytosis is diagnosed, the physician may recommend treatment based on trial and error, with the goal of finding the right combinations of drugs for the individual patient.
Antihistamines appear to compete with histamine for receptor sites on effector cells.
If a cell receptor site is occupied by an antihistamine, it can't chemically interact with histamine, and therefore the chemical cycle is broken before the histamine can work to create a symptom. They tie up different receptor sites than H1 antihistamines, called H2 receptors. The most valuable drug for the emergency treatment of severe Mastocytosis symptoms is epinephrine. The vasoconstrictor effect of epinephrine directly counteracts the vasodilatation produced by histamine. Epinephrine quickly restores circulating blood volume and blood pressure, and quickly eliminates itching and swelling.