Correlates of protective immunity to Mycobacterium tuberculosis in humans. Potential impact of tuberculosis vaccines as epidemic control agents. Comparison of the protective efficacy of bacille calmette-Guerin vaccination against aerosol challenge with Mycobacterium tuberculosis and Mycobacterium bovis. Toward the development of diagnostic assays to discriminate between Mycobacterium bovis infection and bacille Calmette-Guerin vaccination in cattle. Vaccination of mice and cattle with plasmid DNA encoding the Mycobacterium bovis antigen MPB83.
Diagnostic test needs for evaluating antituberculosis vaccines.
Ethical issues in tuberculosis vaccine trials. Improving vaccine performance with adjuvants. Applying experiences from trials of bacille Calmette-Guerin vaccine. Current tuberculosis vaccine development. Simple, practical ways to assess the protective efficacy of a new tuberculosis vaccine.