These studies have focused on aspects of airway cell biology which limit retroviral transduction to the airway, including proliferation and partitioning of retroviral receptors to basolateral membranes. As a pediatric pulmonologist, Dr. McCray is keenly aware of the evidence that CF lung disease begins early in life. Adenoviral-mediated gene transfer to the fetal pulmonary epithelia in vitro and in vivo. In utero gene transfer - an approach to the treatment of inherited lung disease. Proliferation induced by keratinocyte growth factor enhances in vivo retroviral-mediated gene transfer to mouse hepatocytes.
Alveolar macrophages inhibit retroviral-mediated gene transfer to airway epithelia.
Transient surfactant protein B deficiency in a term infant with severe respiratory failure. Wang G, Williamson R , Mueller G, Thomas P, Davidson BL, McCray PB Jr. Ultrasound-guided gene transfer to hepatocytes in utero. McCray PB Jr. Influence of cell polarity retroviral-mediated gene transfer to differentiated human airway. McCray PB Jr. Urinary bombesin-like peptide levels in infants and children with bronchopulmonary dysplasia and cystic fibrosis. Watanabe S, Matsushita K, Stokes JB, and McCray PB Jr. Developmental regulation of epithelial sodium channel subunit mRNA expression in rat lung and colon.