A challenge study showed that Malarone is active against the early liver as well as the blood stage. Among pediatric patients, vomiting and itching were reported adverse reactions. In subjects given Malarone for prevention of malaria, the most commonly reported side effects were headache and abdominal pain. In the event of vomiting, a repeat dose should be taken within 1 hour of dosing. Prophylactic treatment with Malarone should be started 1 or 2 days before entering a malaria-endemic area and continued daily during the stay and for 7 days after return.
Body weight determines the dose for malaria treatment and prevention in children.