Analysis of CSF usually demonstrates moderate increase in neutrophils and mononuclear cells. Intratecal administration of amphotericin B has been used with some success. Pulmonary involvement is usually blood borne. Candida cholecystitis has a high mortality rate, and may extend into hepatosplenic infection in neutropenic patients secondary to aplastic anemia and acute leukemia. Splenectomy has been recommended as a curative treatment for isolated splenic infections if there is no response to medical therapy.
Antifungal treatment is the first line of treatment followed by removal of the catheter.
Diagnosis Candida is a part of normal flora and is often isolated from the urine, sputum and stool as a contaminant. Serologic tests such as determination of complement-fixing antibody titer are useful in diagnosis of the candidiasis. Immune precipitation and latex agglutinin test are neither sensitive nor specific, therefore they are not considered a reliable tool of diagnosis of infection. Biochemical tests like determination of serum enolase has a similar results. Pseudohyphae morphology on wet smear which is associated with positive culture results generally identifies superficial Candidiasis.