In addition, due to ulceration of the colon, brush border enzymes are impaired and mechanical damage inhibits normal absorption. Common micronutrient deficiencies include iron, zinc, vitamins D and B12, and folic acid. Negative nitrogen balance frequently accompanies the malabsorption accompanying CD, caused by the loss of protein as well as inadequate protein intake. A. Therapies are discussed in terms of specific pharmaceuticals, procedures, foods, or regimens. Success rates with sulfasalazine are dose related, with better success rates at high doses.
Corticosteroids are effective in mild to moderate Crohn's disease.
High doses therapy is continued until symptoms begin to diminish, after which the dose is gradually reduced. Corticosteroids should not be used in patients with undrained abscesses or where there are a strictures or fibrotic processes. Maintenance therapy with corticosteroids is ineffective to prevent recurrences of Crohn's disease. The many side effects of corticosteroids are the major factor limiting their use. However, the delay between the initiation of therapy and the clinical response is typically 3 to 6 months.