At post mortem examination she was found to have marked enlargement of both kidneys. There were multiple small cream foci over the capsular surface and darker areas within the parenchyma. . . In some lesions, bacterial colonies may be recognised. The following sections are from an 8 month old foal with focal abscesses in the kidneys, liver and lungs. Foci of mixed inflammatory cells and necrosis are scattered through the kidney, affecting both cortex and medulla.
Bacterial colonies appear as fine granular bluish material within the inflamed area.
This section illustrates the diffuse foci of inflammation in the kidney. . 3- Interstitial Nephritis. This is seen most often in dogs due to infection by Leptospirosis. Haematogenous spread of bacteria results in bacteria localising in proximal tubules. Tubule epithelial cells swell and become necrotic and the bacteria move into the interstitium where they stimulate an immune response with plasma cells and lymphocytes.