However, a neoplasm's metastastatic potential has been proposed to be related to apoptosis. There was no significant statistical difference between eight AFX and nine pleomorphic MFH in terms of apoptotic behavior, proliferative indexes, p53 protein expression, or presence of bcl-2 product. Therefore, our results further support the contention that AFX should be regarded as a form of pleomorphic MFH, which demonstrates low malignant potential by virtue of its location in readily accessible sites. A comparative study of their proliferative activity using MIB-1, DNA flow cytometry, and p53 immunostaining. Oshiro Y, Fukuda T, Tsuneyoshi M. Second Department of Pathology, Faculty of Medicine, Kyushu University, Fukuoka, Japan.
Aneuploidy demonstrates a malignant potential in fibrohistiocytic tumors.