Doctors have found that women who use these products while taking the blood-thinning drug warfarin can show increased reactions to the blood thinner as well as suffer bleeding or bruising. The FDA also asked the manufacturers to notify doctors about the possibility of this drug interaction and the need to monitor patients more closely when they take these drugs together.
Blood thinners work by slowing the clotting action of the blood.
The FDA has learned from two adverse event reports that when some women use these miconazole products at the same time to treat a vaginal yeast infection, they can experience increased reactions to their blood-thinning therapy. Some women showed an increase in the amount of time it took for their blood to clot, beyond what the blood thinner would cause by itself. One woman increased her clotting time and also developed bruises, bleeding gums, and a nosebleed. Read the FDA advisory , which includes references to two medical articles about this drug interaction that you can bring to your doctor. Read an FDA talk paper on the new information to be provided about this drug interaction.