Pymatuning Fishing licenses issued by either Ohio or Pennsylvania are honored anywhere on the lake, but only Ohio licensed fishermen can fish from the Ohio shore and Pennsylvania licensed fishermen from the Pennsylvania shore. Common species of fish in the lake include walleye, muskellunge, carp, crappie, perch, bluegill, and largemouth and smallmouth bass. Ice fishing during the winter months is also popular. An accessible fishing pier is located at the Espyville Marina and the Shenago River. The 3,222-acre Lake Arthur is a warm water fishery.
Common species are northern pike, largemouth bass, channel catfish, black crappie and bluegill.
The Pennsylvania Fish and Boat Commission stock muskellunge, walleye, channel catfish and hybrid striped bass. Volunteers, park employees and Pennsylvania Fish and Boat Commission employees have installed fish habitat throughout the lake. A map showing fish habitat project locations, water depths and specific features of the lake is available at the park office, marina office and the gift shop at McDanel s Boat Launch. A bait and snack shop is located at the Bear Run Boat Launch and is open seasonally. The lake offers bluegills, sunfish, bullheads, catfish, yellow perch, walleye, muskellunge, crappies, sauger, largemouth and smallmouth bass.