Dehydration causes an imbalance in the liquids and dissolved solids in the urine.
The kidneys must maintain a proper amount of water in the body as they remove harmful waste materials. These chemicals and trace elements combine to form crystals that slowly build up and form a stone. Some people do not have a sufficient quantity of inhibitors to prevent crystallization, or their inhibitors may fail to induce the necessary chemical reactions that prevent the formation of crystals, the first step in the development of a kidney stone. Matrix A chemical component of urine, noncrystalline mucoprotein called matrix, is thought to play a role in stone formation. Matrix seems to act as an inhibitor in people who do not develop stones.