Burning in May or June may reduce perennial sowthistle abundance and vigor on grasslands, but it will probably not be an effective means of control. Many herbicides are not specific to this species or may not be specifically licensed for this use. It is important to read and follow all label directions. A few herbicides are available for the control of perennial sowthistle. A mixture of Banvel and 2,4-D has been affective.
Control is generally greater at heavier application rates.
Over 50 insect species feed on Sonchus spp. in Eurasia. Three are being investigated as potential biological control agents. Larvae of this species infest the heads of perennial sowthistle and form galls preventing seed formation. This species of fly has yet to become successfully established. Even if it becomes established, it will probably not be a controlling force.