It is important to determine whether a lipid-based strategy will be effective in clinical alcoholic liver disease. Dietary factors and alcoholic cirrhosis. Beef fat prevents alcoholic liver disease in the rat. Dietary linoleic acid is required for develop-ment of experimentally induced alcoholic liver injury. Role of cytochrome P450 2E1 in alcoholic liver disease pathogenesis.
Dietary lipids coinduce multiple xenobiotic metabolizing enzymes in rat liver.
Ohkawa H, Ohishi N, Yagi K. Assay for lipid peroxidation in animal tissues by thiobarbituric acid reaction. Spectrophotometric detection of lipid conjugated dienes. Imai Y, Ito A, Sato R. Evidence for biochemically different types of vesicles in the hepatic microsomal fraction. Rationale for therapy for alcoholic liver disease. Markedly enhanced cytochrome P450 2E1 induction and lipid peroxidation is associated with severe liver injury in fish oil-ethanol fed rats.