Supplied Research Pharmacology Antipsychotic Agent Loxapine, a tricyclic dibenzoxazepine antipsychotic agent, which is chemically distinct from the phenothiazines, thioxanthenes and butyrophenones, produces pharmacological responses in various animal species which are characteristic of those seen with the majority of antipsychotic drugs. Although the precise mechanism of action is not known, loxapine succinate administration results in strong inhibition of spontaneous motor activity.
Absorption following orally administered loxapine succinate is virtually complete.
The duration of sedative effect is approximately 12 hours. Loxapine is metabolized rapidly and extensively in animals and man and excreted both in the urine and feces. Unmetabolized drug has not been recovered in urine and feces though metabolites are excreted in urine mainly in the form of conjugates and in feces mainly in the unconjugated form. The management of the manifestations of schizophrenia. A syndrome consisting of potentially irreversible, involuntary, dyskinetic movements may develop in patients treated with conventional antipsychotic drugs.