Clinical signs include fever, loss of appetite or coordination, tremors, vomiting and diarrhea.
Death occurs in three-fourths of kittens and about half of adult cats that get the disease.
It is the most serious of the upper respiratory diseases in cats, and, in advanced stages, produces a discharge from both the eyes and nose. Rhinotracheitis can be fatal to kittens and can become chronic. Signs of infection are similar, but cats with calicivirus may also have ulcers on the tongue. Death is uncommon. Signs are similar to rhinotracheitis and calicivirus.