These translocations are demonstrable by RT-PCR techniques. Consolidation - various combinations of chemotherapeutic agents. CNS directed therapy - high dose systemic and intrathecal methotrexate. Maintenance therapy - vincristine, prednisolone, mercaptopurine and methotrexate for 2 years. Allogeneic transplantation is the treatment of choice at relapse.
Allogeneic transplantation is advisable in first remission.