Because of isolated reports of neutropenia and jaundice, periodic blood counts and liver function tests are advisable during long-term therapy. Manifestations of diazepam overdosage include somnolence, confusion, coma and diminished reflexes. Respiration, pulse and blood pressure should be monitored, as in all cases of drug overdosage, although, in general, these effects have been minimal unless overdose is extreme. General supportive measures should be employed, along with i.v. fluids, and an adequate airway maintained. Hypotension may be combatted by the use of levarterenol.
Dialysis is of limited value.
Dosage should be individualized for maximal beneficial effect. The usual recommended dose in older children and adults ranges from 2 to 20 mg i.m. In acute conditions the injection may be repeated within 1 hour, although an interval of 3 to 4 hours is usually satisfactory. For dosage in pediatric use, see Dosage and Warnings. Because of its delayed action, Diazemuls is not recommended for the management of status epilepticus.