Toxic doses are variable and reports of poisonings are limited. There may be an initial euphoria with auditory or visual hallucination and perceptual disturbances. Due to the high lipid solubility, the duration of toxicity can be prolonged. Life-threatening complications are secondary to seizures and respiratory effects of CNS stimulation. Gastrointestinal and dermal decontamination are a priority.
Charcoal is helpful for gastrointestinal decontamination.
Cholestyramine may be used alternatively to bind these highly lipophilic agents. Following ingestion of chlordecone, multiple doses of cholestyramine should be given to interrupt enteroenteric and enterohepatic recirculation. Induction of vomiting is not recommended because of the possibility of seizures. Oxygen and supportive care is given as necessary. Use epinephrine and sympathomimetic amines with caution because dysrhythmias can be induced.