Relapsers during maintenance are removed from the study and given open treatment with Prozac if they relapsed on placebo and alternate pharmacotherapy if they relapsed on Prozac. Non-responders to Prozac will be given alternate antidepressants for up to 3 more months. Most patients with unipolar or bipolar 2 Major Depression without current alcohol or substance abuse are eligible. Previous Prozac treatment does not necessarily exclude potential subjects. Patients who are currently abusing alcohol and also have a depressive disorder are eligible for a 12 week study of Prozac compared to placebo.
All patients get weekly individual counseling using a behavioral model for controlling drinking.
Responders get 6 months follow up treatment with medication provided. Most patients in generally good health who do not need inpatient detoxification are eligible. Depressed adults living with children. Adults with moderate to major depression who are living with children ages 10-16 are needed for a study on parental depression and its effects on children. Participation will involve a phone interview for the parent and questionnaires for both parents and children to complete.