For the Hardy-Weinberg equilibrium to be maintained what condition is NOT necessary. A more accurate carrier frequency based on RFLP analysis of the general female population indicates that only one in 5000 is a carrier. Based on your knowledge of the DMD gene, what may explain the unexpectedly high number of affected males. The DMD gene appears to be refractory to new mutations. Spontaneous mutations in the DMD gene account for a large fraction of affected males.
Affected sons can receive the defective dmd allele from their fathers as well as carrier mothers.
Individuals with this variant of G6PD should not be treated with antimalarials that are strong oxidants, e.g. primaquine. Several cloned DNA fragments from a chromosome specific library failed to hybridize to DNA sequences from dmd patients in Southern blot analyses. No father to son transmission of the defective allele had been found. The frequency of affected males equalled the frequency of 31. Mutations that result in amino acid substitutions have no effect on posttranslational processing.