DPR reviewed the data submitted to support the one-percent diphacinone product and determined that an acceptable rabbit acute dermal toxicity study was still needed. In July 1999, the registrant submitted the results of a new acute dermal toxicity study. After reviewing the data submitted to support the two-percent diphacinone product, DPR determined that an acceptable rabbit acute dermal toxicity study and a dermal irritation study were still needed. In August 1999, the registrant submitted the result of two new studies. DPR found the data to be acceptable and approved an amended label for the two-percent product in June 2000.
Applicators use propetamphos indoors as an insecticide.
DPR initiated the reevaluation based upon illnesses attributed to use of products containing propetamphos. In addition to the reports of illnesses, DPR was also concerned about the potential for overexposure of humans in contact with rooms treated with propetamphos. The registrant submitted the dermal sensitization study in January 1991. Rather than conduct an odor threshold study, the registrant conducted a sensory irritation study. The registrant submitted the results of the sensory irritation study in June 1993.