Classic choreiform movements begin as a piano-playing motion of the fingers or as facial grimaces. As the disorder advances and involves the trunk, a characteristic dancing gait evolves. Patients who develop HD by the time they are aged 35 years often become bedridden within 15-20 years. A dramatic weight loss may occur due to energy expenditure from choreoathetoid movements. Behavioral problems may be the first noticeable issues.
Depression often occurs early in the course of the illness.
Patients may be argumentative, impulsive, or erratic. Dementia develops as the disease progresses. Childhood cases tend to present with rigidity rather than with chorea. Younger patients may develop seizures. Family history is of paramount importance in making the diagnosis.