This week's artwork was donated by Jaclyn, a pediatric cancer patient who received treatment at The Children's Hospital of Philadelphia .
Angiogenesis is thought to play a role in radiosensitivity.
The differences in radiosensitivity are thought to be related to the influence of oxygenation, vasculotoxicity of radiation, and angiogenic factors that inhibit radiation effectiveness. 151 paraffin embedded biopsies were processed for immunohistochemistry and the IMD was determined after staining with anti-CD31. VEGF expression in tunor cells was assessed after immunostaining. The level of VEGF expression did not correlate with local failure. Increasing IMD correlated with local failure as shown with Cox multivariate analysis.