Measured AUC is lower than expected at high doses.
Any suggestion is appreciated.
AUC Dear Dr Tong, Assuming you are using the Calvert formula, it is possible that the problem arises from how you estimate renal function in order to decide what dose to give. We may have error in measurment, calculation or sampling problem, but the trend is the AUC starts to be lower at higher doses. Second is the GFR calculation. We used C and G as well as Jeliff method using serum creatinine. Since serum creatinine can be a function of muscle mass, hepatic function and protein loading.