Prefilled must be refrigerated and used within 21-30 days. Penfill regular can be at room temperature for 30 days after puncture. Avoid freezing temperatures and temperatures above 86 degrees. Insulin should not be left in cars or checked in airline baggage. Clumping or frosting of insulin.
Clear insulin is cloudy or discolored.
It has passed the expiration date. Give injections in different areas, abdomen may be used for most injections, but rotations around abdominal area must occur. Inject into subcutaneous tissue. 90 degree injection angle works for most, children and very thing adults may need to use 45 degree angle. Massaging injection site is usually not recommended.