The hard covering of the seed coat inhibits germination. This may be reduced somewhat by removing the hulls mechanically, whether by commercial machinery or by nicking the hull with sandpaper. Soaking in deionized water may also improve germination. The germination soil should be sterile and well drained to provide the best medium. Other methods of propagation are also difficult.
Cuttings root slowly and with limited success.
Juvenile wood seems to be best. Harvesting established creosotes from desert locations is also a real chore. Old timers once indicated that one must utilize a three year process to achieve the desired results. Root pruning would first be conducted on opposite sides one year, followed by the other two sides the second year and then lifting the plant the third. Yet others indicate that carefully handled shrubs, with no root pruning, transplant well in the spring, summer or fall.