The goal of this study is to generate an immune response to the vaccine, creating immune cells that will circulate and kill tumor cells wherever they are encountered. Treatment options for canine cancer patients revolve around surgery, radiation and chemotherapy. Even with aggressive medical management, the majority of cancer patients die. This antitumor activity is not limited to bladder cancer. The investigators are defining a safe, effective treatment protocol for canine oral cancer and to determine how this therapy works in order to apply it to other forms of cancer.
Canine osteosarcoma is the most common skeletal neoplasm of pet dogs.
It is a highly invasive tumor with a poor clinical outcome. Despite the similarities between human and canine osteosarcoma, little is known about the pathogenesis of the disease in dogs. This study focuses on identifying the oncogenes and tumor suppressor genes that are abnormally expressed in canine osteosarcoma with the goal of eventually developing diagnostic and therapeutic tools to combat the disease. Osteosarcoma is a highly malignant and metastatic cancer involving the bones of large breed dogs. Novel therapeutic approaches are needed to prevent metastasis following surgery and chemotherapy.