Atropine may produce fever through inhibition of heat loss by evaporation. Maintain respiratory exchange. Monitor cardiac function. Appropriate measures should be taken if convulsions occur or shock is present. In the treatment of atropine poisoning, respiratory assistance and symptomatic support are indicated.
Death is usually due to paralysis of the medullary centers.
Response should be monitored carefully and assisted or controlled ventilation secured. Recurarization has not been reported after satisfactory reversal has been attained. Parenteral drug products should be inspected visually for particulate matter and discoloration prior to administration. Pharmacokinetics of edrophonium and neostigmine when antagonizing d- tubocurarine neuromuscular blockade in man. Pharmacokinetics of edrophonium in anephric and renal transplant patients.