Another major interest in the lab is a class of protein phosphatases that are essential for regulating a cell's passage through the cell cycle. We have determined the structures of the catalytic domain of human Cdc25A, and a homologous yeast phosphatase of yet unknown function. Unexpectedly, these proteins have a fold different from other types of protein tyrosine phosphatases. Lastly, we are closely collaborating with Drs. We have recently determined the structure of a novel ribosome-binding protein and an RNA methylase.
Current work is directed towards a chaperone protein, which is regulated by cell oxidation levels.
Nature 370, 571-575. Crystal structure of the catalytic domain of the human cell cycle control phosphatase, Cdc25A. Cell 93, 617-625. Structure of Hsp15 reveals a novel RNA-binding motif. EMBO Journal 19, 749-57. RNA Methylation under Heat Shock Control.