Consequently, the mechanism by which cdks regulate viral transcription remains to be determined. Most cdks are not expressed in non-cycling neurons. We have shown, however, that neuronal expression of cdk-2 is induced by the same stimuli that promote neuronal HSV replication. Cdk expression in non-cycling neurons, thought impossible a few years ago, has became an important area of research recently. Thus, neuronal expression of cdks has been implicated in several neurological pathologies, such as Alzheimer's disease.
Cdk inhibitors have a different mechanism of antiviral action than conventional antiviral drugs.
To address the mechanisms whereby cell-cycle cdks are expressed in neurons during HSV reactivation. Submitted Schang, LM , Bantly, A., Meijer, L, Knockaert, M, Gray, N, Malim.