These beneficial CTL responses diminish with disease progression and cannot be recovered with antiretroviral therapy alone. Recent studies suggest a vaccine may help restore CTL responses.
All patients continue their antiretroviral regimen during the study.
Patients are followed for safety evaluations and changes in viral load through Week 48. I A phase one trial is the first step on a drug's journey to approval. Antibiotics other than those listed in Exclusion - Concurrent Medications. Prophylactic antimicrobial medications, antifungal medications, antipyretics, analgesics, allergy medications, oral contraceptives, topical or inhaled corticosteroids, and other medications deemed appropriate by the local investigator. Nonprescription medications and alternative therapies, such as vitamins and herbal therapies.