Temperature Zones are your choice. If cost is not the primary concern, you can zone each room individually. Time clocks can be added for additional set-back capabilities. This normally should only be considered if the unoccupied time is quite long, ie. Our feeling is that when you lower a temperature in a room for only a single night, with the lag time to bring that area back to temperature and reheat the items in the room, the energy used to bring it back up may offset any intended savings.
Common sense is a good place to start.
If there are rooms that will be affected greatly by direct sunlight , there will be solar gain in those rooms. If you put a thermostat in one of those areas, without additional zones, it would warm up, the thermostat would shut off, and the other areas without solar gain would be starved for heat. So, zone it. If multiples of rooms have the same solar gain, one thermostat should suffice to control those rooms as a separate zone. The reverse is also true.