InterPro InterPro is an Integrated Resource of Protein Domains and Functional Sites. The clustering is based on analysis of all pairwise comparisons between protein sequences. CluSTr is a useful resource for whole genome analysis and has already been used for the proteome analysis of a number of completely sequenced genomes. A Conserved Domain Database and Search Service Proteins often contain several modules or domains, each with a distinct evolutionary origin and function. The CD-Search service may be used to identify the conserved domains present in a protein sequence.
Computational biologists define conserved domains based on recurring sequence patterns or motifs.
The source databases also provide descriptions and links to citations. Since conserved domains correspond to compact structural units, CDs contain links to 3D-structure via Cn3D whenever possible. The query sequence is compared to a position-specific score matrix prepared from the underlying conserved domain alignment. Hits may be displayed as a pairwise alignment of the query sequence with a representative domain sequence, or as a multiple alignment.