Half of the M.M patients have renal pathology. There are various causes, including amyloid deposits, hypercalcemia, hyperuricemia and recurrent infections. Indeed, tubular damage is often seen because of the excretion of light chains that affect directly the tubular cells. Even neurologic symptoms are seen, and they have many causes. Hypercalcemia can lead to lethargy, dizzinness and depression.
Bone fractures can result in medullar compression syndrome and radicular pain.
Carpal tunnel syndrome and mono and polyneuropathies can be caused by amyloid infiltration in pheripheral nerves. Although we have seen generalized distribution of plasmocytes in the body, the tumoral expansion is restricted to the bone and bone marrow, and so, rarely leads to splenomegaly and linphadenopathy. Those variants are seen in younger people and are well treated with radiotherapy. MG doesn't need treatment. We initiate our investigation with a physical examination searching for bone lesions or masses.