Graphically Sanitarium looks excellent. Despite using only a 256 color palette it often looks better than many a high-color game. Locations are varied from drab, dark, and imposing, to bright and colorful. The graphics are all detailed and nicely drawn. Everything looks like it belongs together.
Animations are equally good.
Player and non-player character movement, with a few odd exceptions, is fluid and believable. The sound is also exceptional. You have control of the sound level for the music, video cut scenes, voices, and ambient sound. This lets you balance things perfectly on your hardware. And you'll want to.