PostScript files can be displayed with Aladdin's Ghostscript viewer, while the PDF versions below can be viewed with Adobe's Acrobat Reader . The annotated multiple alignments observe the following conventions. The human DNA sequence is presented on the top line, and its coordinate system begins at a HindIII site located 5' to HS5. For the DNA sequences of nonhuman species, matches with the human sequence are shown as periods and mismatches are shown as the nonmatching nucleotide.
Dashes represent gaps introduced to improve the alignment.
Open boxes are drawn around conserved blocks of columns, or phylogenetic footprints, that are at least 6 gap-free columns long and contain at least 4 rows such that each row has no more than one mismatch compared to an unspecified consensus. A shaded box indicates a differential phylogenetic footprint. This paper also includes an extensive review of the LCR, and can be found at PubMed and Elsevier . Back to the globin home page .