The main side effect of dapsone is anemia, a loss of red blood cells. Stomach upset is also common. Dapsone can also make you sensitive to sunlight. Tell your doctor if your skin gets pale or yellowish, or you get a sore throat, fever, or rash, even after a few weeks of taking dapsone. These might indicate a serious drug reaction.
Dapsone is broken down by the liver.
It can interact with other drugs that also use the liver. Scientists have not yet studied all the possible interactions. Dapsone probably interacts with some blood thinners, heart medications, seizure medications, and other antibiotics. Be sure your doctor knows about all the medications you are taking. Also, ddI can reduce absorption of dapsone.