These vascular tumors typically have a large retinal feeder vessel and vein. Intraocular Lymphoma Primary intraocular lymphoma may mimic inflammatory conditions of the eye, but some cases also have a highly characteristic clinical appearance. Some primary intraocular lymphomas appear to originate in the space between retinal pigment epithelium and Bruch's membrane. Limited vitreous reaction may be present during the early stages of the disease so lesions are usually visible. In time, tumor cells invade the retina, turning it white.
Cells eventually seed the vitreous, thereby obscuring the view of the retina.
The Collaborative Ocular Melanoma Study Group. Accuracy of diagnosis of choroidal melanomas in the Collaborative Ocular Melanoma Study. COMS Report No. 1. Arch Ophthalmol . Errors in the diagnosis of malignant melanoma of the choroid.