The Stemerman Lab investigates the cell signaling pathways leading to atherosclerosis. The effects of low-density lipoprotein and cholesterol are currently being examined as causative agents in the atherosclerotic process.
Cardiovascular disease is the leading cause of death in developed countries.
Furthermore, rapid lowering of the LDL level has an ameliorative affect on vascular reactivity and a sustained lowered level reduces the incidence of coronary disease. The benefits of lowered LDL appear to derive from lesion stabilization, increased vascular reactivity, improved endothelial function, and a decreased inflammatory response. Our laboratory The objective of this laboratory is to examine artery vessel wall reactions to a variety of stimuli, and to understand the resultant mechanisms leading to atherosclerotic plaque formation. Our studies focus on the vascular endothelium and the effects of LDL on these cells. We have been actively engaged in examining the process of LDL activation of endothelial cell function since 1984.