A stool guaiac test may be positive. An underlying infectious etiologic agent should be excluded when clinically indicated. Skin biopsy may show a leukocytoclastic vasculitis. Bed rest and supportive care, such as assuring adequate hydration, are helpful. Nonsteroidal anti-inflammatory drugs can relieve joint and soft tissue discomfort.
Corticosteroids have some use in patients with severe abdominal pain.
However, corticosteroids are not recommended for treatment of rash, joint pain or renal disease alone. The illness lasts four to six weeks in most patients. One half of patients have a reccurrence. The renal disease may not arise for several years. Renal biopsy may be performed to establish the diagnosis and determine the prognosis.