Kawasaki disease symptoms include fever and rash, which include bright red, swollen lips that crack and bleed. Juvenile Scleroderma Juvenile scleroderma is rare in children but includes both localized and systemic disease. Systemic scleroderma is similar to that experienced by adults and includes Raynaud's phenomenon and skin, musculoskeletal, gastrointestinal, pulmonary, cardiac or renal involvement. Raynaud's phenomenon is often a symptom of connective tissue diseases, especially scleroderma. Sjogren's syndrome is often called Sicca syndrome if it is a symptom of connective tissue diseases.
Diagnosis is made by skin biopsy with evidence of inflammatory cells in the subcutaneous tissue.
Hypermobility syndrome represents extreme variation of the usual range of joint motion. Girls are more often affected than boys, and frequently there is a family history of hypermobility. Non-inflammatory disorders are important causes of chronic or recurrent pain in children. The cause of growing pains is unknown. They occur equally among boys and girls.