Attics stink, literally and figuratively.
In most homes, the roof is too low, the blown-in insulation is guaranteed to leave you sneezing, the ventilation is negligible, and as we all know there are ghosts and witches up there. So don't drag all your equipment up those rickety steps yet. Assuming you never have clients visit your office, the basement can be a fine place to locate your home office. No matter how dry your basement is, one day the rain is going to come in. It might seep through the floor or come in through the wall, but anyone who has lived or worked in the same place for an extended period of time knows that the occasional drip or waterfall is an inevitable part of working in a basement.