Most RCC is associated with a terminal deletion of the short arm of chromosome 3. Papillary carcinomas are associated with trisomy 7 and 17. Smoking is a predisposing factor. These changes are reversible following nephrectomy. Seventy percent of RCC is of the clear cell variety.
Caution is advised.
Clear cell carcinoma tends to be of low grade. Murphy, W., et al. Tumors of the Kidney, Bladder and Related Urinary Structures. AFIP Atlas of Tumor Pathology. 1993. Kelalis, King, Belmar.