Horses do not become infected. This is accompanied by a drop in milk production, refusal to eat and a depressed appearance. Excessive Salivation - The disease causes painful blisters on the tongue and mouth.
Cattle make characteristic tongue sucking and lip smacking sounds.
Lameness - Blisters form just above the hooves especially in between the toes. Once the blisters are broken, these lesions look similar to foot rot. In cows producing milk, it is common to have blisters form on the teats. Although the characteristic lesions on the muzzle, tongue, mouth and teats are a fluid filled blister known as a vesicle, these break within a day. The blisters are replaced by erosions as the surface layer of skin and mucous membranes loosen and peel away.