Design Two-period, outpatient crossover trial conducted from September 1997 to September 1999. One regimen used butter only and the other used margarine only. Main Outcome Measure Mean LDL-C levels during the last 2 weeks of each dietary period. The distribution of individual responses were peaked around the mean response. Our results suggest that individual variation in response to a cholesterol-lowering diet is a familial trait.
Body weight is an important modifiable factor that influences response.
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