This reduces the amount of fluid in the blood. And since sodium is flushed out of blood vessel walls, the vessels open wider. Pressure goes down. There are different types of diuretics. They are often used with other high blood pressure drugs.
Blood pressure drops and the heart works less hard.
They shield blood vessels from a hormone called angiotensin II, which normally causes vessels to narrow. As a result, the vessels are wider and pressure is lower. They relax blood vessels and pressure goes down. Blood vessels relax and pressure goes down. One short-acting type of CCB has been found to increase the chance of a repeat heart attack.