Biological and therapeutic compatibility . Restorative material compatibility. Absence of biological side effects. Eugenol and non-eugenol materials can be toxic to fibroblasts in vitro. Cyanoacrylates are definitively toxic to tissues.
Animal studies are conclusive on the higher toxicity of dressings containing eugenol.
Cyanoacrylates with long side chain molecules are lesser irritants than those with short side chain. Absence of tissue adaptation disturbance. Eugenol and colophony were demonstrated to sensitize patients.