Current emphasis is on neuropeptides.
We are also interested in the development and use of differentiated human and animal cell culture systems for investigations on the mechanisms of uptake, metabolism and cytotoxic actions of environmental chemicals, such as the marine agent palytoxin, and the cellular, biochemical and molecular actions of tumor promoters. Petrou CP and Tashjian AH Jr. Evidence that the thyrotropin-releasing hormone receptor and its ligand are recycled dissociated from each other. Jr. Importance of extracellular domains for ligand binding in the thyrotropin-releasing hormone receptor. A new model for TRH binding. Jr. Overexpression of protein kinase C epsilon is oncogenic in rat colonic epithelial cells.