Young children are usually affected. The Epstein-Barr virus is rarely associated with endemic Burkitt's lymphoma. There is a high frequency of extranodal involvement. The neoplastic population is monotonous looking. Nucleoli are prominent.
Cytoplasmic vacuoles are common.
They are aggressive and typically extranodal. Most exhibit p53 gene mutations. A good prognostic indicator is an immunoblastic subtype.