This flushes endometrial debris off of surface and into vagina. Blood that seeps into uterine cavity clots but the clots are quickly dissolved by fibrinolysin. The prostaglandin mentioned above also causes mild rhythmic contractions of myometrium. As soon as functional layer separates from the basal layer, the epithelial cells of the tips of the uterine glands located in the basal layer begin to divide. This is the very first act of regeneration of the functional layer.
All cells used in rebuilding come from basal layer of endometrium.
Stimulated by estrogen. See Marieb for more information. Estrogen causes endometrial cells to exhibit receptors for progesterone. Progesterone causes stromal cells to store glycogen, conn. Multiple neuronal centers in limbic system transmit impulses to arcuate nucleus, etc.