Pompholyx occurs at palm and soles. Blisters at sites of frequent trauma suggests Epidermolysis Bullosa. Mucosal membrane involvement is frequently found in pemphigus, erythema multiforme and fixed drug eruption. Aureus and occasionally by Strep. More common in children and mainly affects face and hands.
Bullae are flaccid and usually contain pus.
When the pustules are ruptured, they give rise to golden crusts. Female is more commonly affected than male. The peak incidence occurring at the age of 40-50. The eruption occurs mainly in the groins, axillae, submammary areas and the flexor aspect of the limbs. The face is never affected, nor are the mucous membranes.