This was accompanied by renal histopathology consisting hyperplasia in the collecting duct, transitional cell hyperplasia, cortical atrophy with fibrosis and scarring accompanied by chronic vasculitis, interstitial nephritis, dilatation of Bowman's space, and deposition of lipofuscin pigment in cortical tubules. These neurologic symptoms were accompanied by histopathological findings in the vermis cerebellum. Two males and 1 female were killed between weeks 39-51 due to severe neurological effects. The uncertainty factor of 100 reflects 10 for interspecies extrapolation and 10 for intraspecies variability. The principal study is of good quality and is given a high confidence rating.
Additional studies are of adequate quality and supportive of the critical study.
Therefore, the data base is given a high confidence rating. High confidence in the RfD follows. This assessment is not presented in any existing U.S. EPA document. Not available at this time. Not available at this time.