You can check the spectral response curve of several cameras by consulting the spread sheet on our web site. You should consider this issue carefully. If you have to integrate longer, then the specimen may bleach over time. This is especially true if you are attempting to acquire a stack of images for 3D reconstruction. Speed Camera acquisition and readout speed are other important issues.
Different cameras have different readout speeds.
If you are working with fixed specimens and dyes that do not photobleach easily, then you can use a camera with slower readout times. Note that a faster readout increases the noise in the image. If you are working with live specimens, doing calcium ratio imaging, or working with specimens that photobleach easily, you will want the greatest sensitivity and the fastest readout times. Noise and bit depth Your specimens are related to the noise and bit depth of the camera you choose. If your specimens are dim and you have to integrate a long time, or you have to capture images quickly, then the noise will be greater in the images.