Stages C and D are treatable, but their prognoses are discouraging. Subdivisions that reflect specific conditions within each category have been added to the Jewett system. This expanded, alphanumeric system is called the Jewett-Whitmore system. Cancer cells are well differentiated. A2 - Moderately or poorly differentiated.
Cancer cells are present in several locations within the prostate.
B2 - More extensive, involving one or both prostate lobes. C1 - Localized, extending outside the prostate capsule. C2 - Tumor causes bladder or urethral obstruction. D0 - Metastatic, clinically localized, but showing elevated blood PAP levels. D2 - Distant lymph nodes, bones or organs involved.