Application is very simple.
No mixing is required. The section surface follows the contours of the tissue during the cutting action, effectively cleaving the section from the block ahead of the knife edge. This produces a highly exposed surface of proteins and nucleic acids for subsequent access by incubating solutions of antibodies, stains and probes. The resin preserves these structures without chemically interacting or cross linking with them. It also minimizes the denaturation of proteins, allowing true antigenic properties to be maintained.