The intrinsic pathway is triggered when thromboplastin is released from the platelets and the intermediates of the pathway are activated on the platelet surfaces. From this point on the clotting mechanism is the same. Clot formation is usually completed within 3 - 6 mins. 30 - 60 mins after clot is formed it stabilised further by clot retraction or syneresis. Platelets release actomyosin which causes the platelets to contract, squeezing and pulling on the fibrin strands, squeezing serum out.
Clot is compacted and the ruptured edges of the blood vessel drawn closer.
Fibroblasts make connective tissue and endothelium regenerates. Rapid removal of coagulation factors by circulating blood. Inhibition of activated clotting factors. Fibrinolysis disposes of clots when healing complete is crucial. A clot digesting enzyme plasmin which is produced when plasminogen is activated.