Yes, there is a point at which ACE inhibitors probably offer no preservation of renal function and may worsen it.
Beta blockers do so by slowing heart rate.
Up to this point, use of ACE inhibitors has important benefit in slowing progression of renal disease. There is no volume depletion from excessive diuretic use, diarrhea, or other cause. Curbside Consults brings the consultant to you. Send us your question. If its answer would be of value and interest to our audience of primary care physicians, you may see it in an upcoming issue.