Recently, several other viruses, including calicivirus and Norwalk virus, also have been shown to be causative agents of pediatric diarrhea. Our three-dimensional structural analyses have provided architectural descriptions of these viruses. Rotavirus is a member of the virus family Reoviridae. In favorable circumstances, x-ray crystallography is being used to study either entire virus particles or their protein components. We have recently determined the structure of Norwalk virus capsids to atomic resolution by using x-ray crystallographic techniques.
Arrows indicate the spikes emanating from the surface of the virions.
X-ray crystallographic structure of the Norwalk virus capsid. The structure of a cypovirus and the functional organization of dsRNA viruses. Nat Struct Biol. Comparative structural analysis of transcriptionally competent and incompetent rotavirus-antibody complexes. Chiu W. Structural localization of the E3 glycoprotein in attenuated Sindbis virus mutants.