Vaccine is killed bacteria, but LPS in whole killed bacteria presents a problem. The national vaccine compensation act set up a trust fund to compensate parents of children who die or are injured from the vaccine. This increased cost, plus adverse publicity has led some parents to neglect immunization. 3.Recently a subunit vaccine has been developed and is licensed in the US for the 4th and 5th doses. Later, as bacteria and mucus from thick ropy masses on trachea and bronchi, get violent, paroxysmal coughing, possibly cyanosis.
Bacteria attach to cilia in trachea,produce a toxin that destroys the cilia.
Serious because fluid rapidly accumulates in the alveoli and prevent gas exchange. Often is a secondary infection after flu or another lung disease. Transmitted by respiratory droplets and by carriers who have had contact with pneumonia patients. At first , symptoms are those of a mild URT infection, then violent chills and high fever, chest pain, cough, sputum containing pus and blood. Can kill in 24 hours.