Whole animal models and cell culture systems are used to study neuronal injury induced by abnormal neuronal excitability. Anatomic, biochemical and molecular techniques are used to characterize and modulate activity-dependent injury and cell death.
Current projects focus on trophic factors and intracellular signal transduction pathways.
Applicants should possess a Ph.D. and preferably experience in whole animal models or primary neuronal cell culture. Expertise in immunohistochemical techniques, neuroanatomy or neurophysiology would be an advantage. This service evaluates and treats complex and refractory epilepsy patients using the latest clinical and technological approaches. This position is ideal for an individual who has completed their Neurology or Neurosurgery residency training and is seeking to develop research skills while advancing their knowledge of a neurological sub-speciality. Extensive laboratory and clinical facilities are available at MGH, and a wide range of potential collaborators is easily accessible within the Harvard and Boston scientific communities.