MCMS Feedback Page . Paget's disease usually centers in one or more of these areas. Once established, however, it rarely spreads to other areas. With early diagnosis and treatment, most people who have Paget's disease are able to lead active, independent lives. To understand what happens in Paget's disease, it is helpful to understand the difference between normal bone cell activity and Pagetic bone cell activity.
Bone is active and living tissue that constantly is being remodeled in a three-stage process.
Finally, the bone hardens when calcium is added to the framework laid down by the osteoblasts. Normal bone cell activity is a very controlled process that is necessary for bone development and repair throughout life. The bone turnover process slows somewhat after puberty and continues at a slower rate through adult life. Bone affected by Paget's disease is broken down faster than usual. Consequently, new bone formation increases.