The six fraternities residing on Greek Row are Beta Theta Pi, Delta Kappa Epsilon, Phi Delta Theta, Phi Kappa Tau, Sigma Alpha Epsilon, and Sigma Chi. A fourth sorority, Alpha Delta Pi, was added in the fall of 1999. Greeks at Centre can be found helping in campus events, volunteering in Danville and the surrounding communities, and hosting great parties that are open to all students. Alpha Phi Omega has Greek letters, but it's not a social organization. It's a co-ed service fraternity.
Centre offers many academic clubs and societies.
For instance, the American Chemical Society, Economic Society, Law Society, and Pre-Med Society are all organizations present on campus. Centre also offers academic honor societies, one of which, Phi Beta Kappa, is the only chapter at a private school in Kentucky. In addition to Phi Beta Kappa, Centre has a chapter of Omicron Delta Kappa, a leadership fraternity, and academic fraternities delineated by major.