Systemic symptoms such as headache, vomiting, fever and myalgias occasionally occur. Methemoglobinemia and hemolysis rarely occur. The best treatment is these is probably watchful waiting. Some have advocated dapsone, but there is little evidence to support its use and there are many potential side effects. Other therapies such as steroids, antivenom and colchicine have all been advocated.
Antibiotics are useful if infection is present.