You constantly feel fatigued. You are becoming inefficient, and enjoying life less and less. The ongoing pressures of daily life can wear you down. Unmanaged stress can lead to high blood pressure, elevated blood sugar and blood lipids, ulcers, tension headaches, allergies, backaches, a depressed immune system, or a premature heart attack. Overloaded circuits do have a way of blowing a fuse.
Constant stress can cause fatigue followed by depression.