An inherited disease that belongs to a group of diseases called mucopolysaccharidoses. Newborn infants with this defect appear normal at birth but, by the end of the first year, signs of impending problems begin to develop. The children slowly develop coarse thick features, prominent dark eyebrows, cloudy corneas, progressive stiffness, and obvious mental retardation . The disease damages many organs including the heart and heart valves.
Death occurs in the early teens, often from the associated heart disease .
Genetic counseling is important for prospective parents with a family history of Hurler syndrome. In addition, tests are available for the prenatal diagnosis of Hurler syndrome. The test consists of an amniocentesis and collection of amniotic fluid . There is no specific treatment for Hurler syndrome. Therapy must address specific developing problems.