These symptoms, including dystonic reactions, akathisia, and motor tics, are likely to be the result of an indirect effect on dopaminergic receptors and typically resolve upon discontinuation of therapy. In addition, suicidal ideation has been reported in both children and adults receiving SSRIs, although this is difficult to assess apart from the underlying illness. In a retrospective review of 42 children between the ages of 10 and 17 years treated with fluoxetine, King et al 9 found six children with self-injurious ideation and behavior. Four of the children had a positive history, but worsened on therapy. All patients responded to discontinuation of fluoxetine and management with other medications.
Death associated with overdose appears to be rare.
The patient exhibited signs of agitation followed by a period of unresponsiveness. The patient's symptoms resolved without treatment. As in this case, most patients recover without sequelae. The degree of metabolism through the CYP2D6 pathway influences the degree of severity of many of these drug interactions. SSRI Drug Interactions Precipitant Object Result MAO Inhib.