Topical tretinoin is believed to decrease microcomedone formation by decreasing the cohesiveness of follicular epithelial cells. Also believed to increase mitotic activity and increase turnover of follicular epithelial cells as well as decrease keratin synthesis.
Absorption is enhanced when the drug is taken with food.
For those individuals who do not achieve palliation using comprehensive skin care and sun avoidance programs alone. Treat various forms of skin cancer. Dermatologic conditions including lamellar ichthyosis, mollusca contagiosa, verrucae plantaris, verrucae planae juveniles, ichthyosis vulgaris, bullous congenital ichthyosiform, and pityriasis rubra pilaris. To enhance the percutaneous absorption of topical minoxidil. After induction therapy with tretinoin, clients should be given a standard consolidation or maintenance chemotherapy regimen for APL, unless contraindicated.