DNA image cytometry may provide additional information about the prognosis of resected thymoma. Thymoma is the most common tumor of the anterior mediastinum. This tumor is associated with unique paraneoplastic syndromes, such as myasthenia gravis, hypogammaglobulinemia, and pure red cell aplasia. The rarity of this tumor, however, has somewhat obscured the optimal treatment for this disease. For the majority of patients who present with localized tumor, surgical extirpation remains the standard of choice.
Adjuvant radiotherapy seems to improve local control and survival.
These observations have led to the development of multimodality therapy for the treatment of patients with advanced thymoma. In this article, we will review the current perspectives on the management of early stage and advanced thymoma. 43 years of experience. The biological behavior of thymoma and its prognosis after surgical intervention remain still controversial. Clinical staging was based on Masaoka's staging system, and histological classification on Rosai's proposed criteria.