Don't open the hood if you can avoid it. Shoot extinguishers through louvers, radiator, or from the underside of the vehicle. For a cargo fire in a van or box trailer, keep the doors shut, especially if your cargo contains hazardous materials. Opening the van doors will supply the fire with oxygen and can cause it to burn very fast. Use the Right Fire Extinguisher.
C type is designed to work on burning wood, paper, and cloth as well.
A burning tire must be cooled. Lots of water may be required. If you're not sure what to use, especially on a hazardous materials fire, wait for qualified firefighters. Extinguish the fire. When using the extinguisher, stay as far away from the fire as possible.