Amino-terminal processing is one of the most common protein processing events, which occurs in all living cells and is essential for normal cell growth.
Angiogenesis is the process of new blood vessel formation.
It plays very important roles in both physiological states and a variety of pathological states. It has been demonstrated that angiogenesis is essential for the growth of solid tumors. It has shown significant anti-tumor activity against 55 different types of human and animal tumors. Ovalicin, on the other hand, possesses potent immunosuppressive activity as well as anti-angiogenesis activity. The broad goal of our research project is to understand the mechanism of the amino-terminal processing of eukaryotic proteins, and its role in angiogenesis.