This is as effective as 10 mg intramuscular morphine. Adverse effects were mild and transient.
Analgesic effects are due to both peripheral and central effects.
It is a potent inhibitor of cyclo-oxygenase, which results in marked reductions in prostaglandin synthesis. In 1996 ibuprofen accounted for nearly 5.5 million prescriptions in England. Systematic review SL Collins, RA Moore, HJ McQuay, PJ Wiffen. This was not true for 50 mg. Data from standard and soluble formulation trials were pooled as there was no difference in the NNTs generated by different formulations at 400 mg.