Many times fatal due to shock and breathing difficulty. Examples are IVP dye and penicillin. They are eggs, peanuts, tree-grown nuts, milk, soy, fish, wheat, and peas. Cytotoxic Reaction s result from activation of complement when and antigen-antibody complex is formed. IgG or IgM may be involved.
Complement lyses the host's cell which then releases it's contents.
The best known example of this type of reaction is a transfusion reaction. During this reaction the host's own cells are lysed. To understand this better we will discuss the ABO and Rh blood grouping after discussing Types III and IV reactions. People can be hypersensitive to drugs by this system. Drugs may coat platelets, red or white cells which then rupture and release their contents.