The most common adverse reactions are confined to the gastrointestinal tract. To achieve minimal GI disturbance with an optimal LDL-C lowering effect, a gradual increase of dosage starting with 2 grams, once or twice daily is recommended.
Constipation is the major single complaint and at times is severe.
Most instances of constipation are mild, transient, and controlled with standard treatment. Some patients require decreased dosage or discontinuation of therapy. Hemorrhoids may be aggravated. Bleeding hemorrhoids and blood in the stool have been infrequently reported. Peptic ulceration, cholecystitis, and cholelithiasis have been rarely reported in patients receiving colestipol hydrochloride granules, and are not necessarily drug related.