Botryoid rhabdomyosarcoma occurs as a peculiar entity in young large breed dogs. These tumors originate from embryonic myoblasts. Microscopically, the primitive cells are anaplastic. This disease examplifies both inflammation and neoplasia. It occurs in mature cattle and is attributed to prolonged ingestion of bracken fern or other ferns.
Bracken fern contains several toxic and carcinogenic substances such as quercetin and aminase.
The syndrome is characterized by persistent hematuria, anemia and pancytopenia. The microscopic change in the urinary bladder is inflammatory. Urinalysis - qualitative and semiquantitative evaluation of renal products. Normally, for every doubling in serum creatinine concentration, the GRF declines by one-half. Normal serum creatinine concentration is 1.