Cell migrations are critical for proper patterning during metazoan development.
The CANs are a pair of neurons that migrate during embryogenesis from the head to the middle of the animal. We performed two genetic screens for mutations that perturbed CAN cell migration. We assigned the 30 mutants from the two screens to at least 11 genes based on genetic mapping and complementation tests. The migrations of other cells are being examined in these mutants to determine whether they are also perturbed. Mutations in most genes identified perturb many cell migrations.