The Laboratories of Endocrinology occupy ca. The hormone-servicing laboratory, which is fully computerized, uses frontline technology for assaying about 40 hormones, hormone intermediates, and other tests of interest in endocrinology to cover the needs of the Hadassah Hospitals as well as of outpatients. The research laboratories are fully equipped with all facilities needed for modern advanced research in cell and molecular biology aspects of endocrinology. The clinical interests of the department covers all aspects of general endocrinology with special emphasis on the field of diabetes and on the quest for tight control of the glycemia. Research Topics Studies on the regulation of insulin production .
All diabetics demonstrate absolute or relative insulin deficiency.
In type 2 diabetes, insulin secretion as well as the maturation of the hormone in the pancreatic islet are modified. The mechanisms of such modifications are investigated by isolating islet cells and studying them either by conventional incubations and perifusions, or by employing a novel system of adult islet culture on extracellular matrix-coated plates, developed in our laboratory. This work is the product of collaboration between Dr. Rafael Nesher, Prof. Nurit Kaiser, Prof. David Gross and Dr. Danielle Melloul in our laboratories. Studies on the molecular control of glucose transport. A second defect in diabetes concerns the efficiency by which tissues take up glucose from the bloodstream.