Revolvers should be used double-action for defense. Double-action may be more of a challenge to master for some shooters. Revolvers generally don't require releasing a safety to fire them. This may be an advantage or a disadvantage, depending on your point of view. The fit of a revolver in your hand can be adjusted, within limits, by changing the grip stocks.
Autoloaders generally have a smaller range of adjustment available here.
A .357 Magnum revolver, for example, can fire anything from the lightest .38 Special target load to virtually any .357 Magnum loading. The revolver's ability to keep firing is independent of bullet shape. If a bullet won't cycle up the feed ramp of an autoloader, the gun will not continue to function. Autoloaders are available in practical single-action mode, if that is better suited to you. Many models of autoloaders have safety levers which can delay someone who gets hold of your gun from using it against you.