Who Have Failed Approved Chemotherapy. Select File and then Print from your browser's menu. Who Have Failed Approved Chemotherapy. Aphton is also evaluating the design and timing of a similar trial in Europe. Aphton is also currently conducting pivotal and other advanced phase clinical trials in the US and Europe for pancreatic, colorectal and gastric cancer patients.
Colorectal cancer is the second most common cause of cancer death in the Western world.
Its rate of incidence increases steeply with age. Presently, in the US alone, there are an estimated 760,000 people with diagnosed colorectal cancer, with more than 130,000 new cases being diagnosed yearly. With the prognosis so grim, the need for improved colorectal cancer therapy, particularly for chemo-refractory patients, is large and urgent. Gastrin has been established as a central hormonal growth factor that stimulates gastrointestinal cancer cells to proliferate and spread. Aphton Corporation is a biopharmaceutical company in late-stage, pivotal Phase III clinical trials.