The clinical manifestations of Lyme disease are diverse and nonspecific. Other symptoms may include fever, muscle aches, joint pain, fatigue, headache, and enlarged lymph nodes. Very rarely children may develop neurologic or cardiac manifestations. The diagnosis of Lyme disease is difficult without the characteristic rash. Laboratory tests are rarely helpful.
Diagnosis depends on knowledge of potential tick exposures, and the clinical symptoms.
Fortunately, Lyme disease is easily treated with a variety of oral antibiotics. Recently a vaccine was developed. It is not approved for children under 15 years of age. Three doses are required. It is uncertain how long immunity will last.