Serotonin causes a decrease in the physiological level of activity including a reduction in food intake and somnolence. Fenfluramine both releases and prevents the reuptake of serotonin and unlike other drugs in this class, can produce CNS depression. In theory, use of anorectic drugs with different mechanisms of action may be used in combination to enhance efficacy, reduce tolerance and allow lower dosages than when agents are used alone. Palpitations and decreased libido occur infrequently.
Continuous therapy is associated with fewer side effects than intermittent regimens.
20mg TID before meals. These two medications may be prescribed concomitantly for obesity and have been added to the KUMC Formulary. Patients must also have no history of substance abuse. Medications - anorectic medications limited to uncontrolled and class IV controlled substances in dosages consistent with manufacturer recommendations. Combination Therapy - limited to treatment regimens using agents from different classes and based on positive results published in peer reviewed journals.