These techniques are the basis for generation and analysis of mutant mice via microinjection and embryonic stem cell manipulation and transfer. We will discuss the uses of these technologies in studies of mammalian development and in generating animal models of disease. A seminar series on the application of gene targeting and transgenics in various research areas will run concurrently with the course. Most participants in the Carolina Workshops already hold M.D. or Ph.D. degrees, or are advanced pre-doctoral students. The courses are designed for novice students as well as for individuals with prior experience.
All students benefit from in-depth interaction with instructors.
Applicants should be familiar with the theoretical basis and general techniques of molecular biology. Manipulating the Mouse Embryo by B. Hogan, et. Previous experience running this course indicates that both students with and without any prior hands-on experience with tissue culture and mouse genetics will find the course useful. Applicants should contact the program office as soon as possible. Full consideration will be given to applications received by June 15, 1998.