Prevalence of adrenal and extra-adrenal Conn syndrome in hypertensive patients. Bilateral adrenocortical carcinoma showing loss of heterozygosity at the p53 and RB gene loci. Malignant acanthosis nigricans in adrenal carcinoma. Trauma and cancer are entities that are encountered frequently by surgeons and occasionally may exist simultaneously in certain patients. Illustrated here is the case of a man with a perinephric mass, discovered during evaluation for blunt abdominal trauma, which was originally thought to be a perinephric hematoma and later proved to be an adrenocortical carcinoma.
Clinical case reports.
Mitotane was stopped because of severe adverse effects. Thereafter a combination of cisplatin and etoposide was given every 3 weeks. A partial response was achieved after five chemotherapy courses. Following this chemotherapy, the patient had a surgical excision of the liver metastasis and entered into a complete remission for 17 months. Etoposide plus cisplatin may be an active combination for the treatment of adrenal cortical carcinoma.