As with any antibiotic product, overgrowth by nonsusceptible organisms may occur, if this occurs, institute appropriate measures. Articles in the current medical literature indicate an increase in the incidence of allergies to neomycin in patients with stasis ulcers or eczema. The possibility of such a reaction should be borne in mind. Following the application of powder to substantial areas of burnt or broken skin, significant systemic absorption of active ingredients may occur. Following significant systemic absorption, neomycin sulfate can intensify and prolong the respiratory depressant effect of neuromuscular blocking agents.
Anaphylactic reactions are rare.
In the event of signs of toxicity developing following significant absorption of the active ingredients, the patient's general status, hearing acuity and renal function should be monitored and blood levels of neomycin and zinc bacitracin determined. Serum levels of neomycin can be reduced by hemodialysis. Polythene insufflators of 15 g. Store between 15 to 30 C and keep dry.