During the lytic cycle, there is an ordered expression of viral genes. Progeny virions are assembled in the nuclei of permissive cells 6.
Adenoviruses cause upper respiratory, intestinal, and eye infections in humans.
Some strains of Adenovirus induce tumours in newborn rodents while infections of nonpermissive cells can result in cell transformation. Rowe recognized that a transmissible agent was killing the epithelial cells. Similar viral agents were isolated from military recruits presenting fever with a variety of respiratory illnesses. In 1962, Trentin demonstrated that Ad12 caused tumours in rodents, first description of a pathogenic human virus that could induce malignant tumours in animals. This realization thrust adenovirus into the forefront of molecular biologic research, producing a detailed understanding of both the lytic and transforming cycles.