Hyper-reactivity is another form of overreaction to a drug. These varied responses to a drug explain need for medical monitoring. G. Tolerance refers to a decrease in drug effect after repeated administrations of the same dosage. Different forms of tolerance. Metabolic tolerance occurs when liver enzymes are induced by repeated use of a drug.
Cellular tolerance involves a change in the nerve cell as an adaptation to repeated use of a drug.
Behavioral tolerance occurs when the individual learns to act normally despite the presence of a drug. Conditioned tolerance occurs with repeated use of a drug in a specific environment. Cross tolerance occurs when experience with one drug causes tolerance to another drug. Tolerance can develop at different rates for the various drug effects. Physical dependence might accompany tolerance.