The scores for the ascending colon and cecum did not reach statistical significance. The authors concluded that the degree of improvement in colonic cleansing may not be worth the routine addition of cisapride to PEG-ELS lavage. The symptom scores between the two groups were not statistically different either, and the authors were unable to identify a subgroup of patients who had a significant improvement in symptom scores based on baseline gastrointestinal symptoms. These studies seem to suggest that the current practice of pretreating patients with metoclopramide or cisapride may not be cost-effective. These effects have rarely been reported with all agents.
Blood dyscrasias are more likely in patients with serious concomitant illnesses.
They appear to be reversible and tend to occur within the first 3 days of administration. This has been reported with cimetidine and is more frequent with long term high dose therapy. There are isolated reports of gynecomastia due to ranitidine and famotidine. Hepatic effects have been observed with all agents. This dosage form may be of interest to patients who have undergone gastric banding procedures and who may not tolerate tablet formulations.