There is limited experience in patients who took moclobemide before meals. Most clinical trial protocols specified that the drug be taken immediately after meals. Treatment with moclobemide does not necessitate the special dietary restrictions required for other available MAO inhibitors. However, until further studies are carried out, patients should be advised to avoid the consumption of excessive amounts of aged or overripe cheese and yeast extracts. Hypertensive patients should be cautioned to avoid excessive consumption of foods that are high in tyramine content.
Data involving other tricyclic antidepressants is limited.
Therefore, the concomitant use of moclobemide and tricyclic antidepressants is contraindicated. Clinical data are not available on the concomitant use of moclobemide and selective serotonin re-uptake inhibitors, or other available MAO inhibitors. Therefore, until clinical data become available, moclobemide should not be administered in combination with these agents. When switching patients from serotonergic antidepressants to a conventional MAO inhibitor, it is standard practice to allow for a washout period equivalent to at least 4 to 5 half-lives of the previously administered drug or any active metabolites. This recommendation also applies to moclobemide.