Native Americans use peyote in their religious rites much as members of other religions might use wine and bread. Spectacular optical hallucinations, perception of color, shape, movement. Bad trips can exhibit the terrifying symptoms of psychosis. Cocaine inhibits the active reuptake of norepinephrine into presynaptic nerve terminals. Crushing psychological depression Deep, often uncontrollable urge for more cocaine.
Amphetamines mimic the human body's own stimulant, norepinephrine .
All of the above times 100. Psychosis, vomiting, irreversible brain damage, extremely violent behavior. They are so named due to their depressive action on the body and mind. Barbiturates are used as sleeping aids, anesthetics and anti-anxiety agents. It is generally considered extremely dangerous and unpredictable.