EEG may show dysrhythmias. The prognosis in cases of severe poisoning is critically dependent upon prompt elimination of the drug , which may be achieved by inducing vomiting, irrigating the stomach , and by taking appropriate steps to diminish absorption. If these measures cannot be implemented without risk on the spot, the patient should be transferred at once to a hospital, while ensuring that vital functions are safeguarded. There is no specific antidote. Even when more than 4 hours have elapsed following ingestion of the drug , the stomach should be repeatedly irrigated, especially if the patient has also consumed alcohol.
Dialysis is indicated only in severe poisoning associated with renal failure.
Replacement transfusion is indicated in severe poisoning in small children. Keep the patient's legs raised and administer a plasma expander. If blood pressure fails to rise despite measures taken to increase plasma volume use of vasoactive substances should be considered. A fully developed aplastic anemia will require appropriate, intensive monitoring and therapy , for which specialized consultation should be sought. Likewise, on theoretical grounds its use with monoamine oxidase inhibitors is not recommended.