The withdrawal of many chlorinated hydrocarbons from the market has increased the importance of this class of pesticides. The signs produced are predictable and are related to the degree of poisoning. Insect cholinesterases are more sensitive to the action of these drugs than mammals and toxicity to mammals is also controlled somewhat by decreasing bioavailability through manipulation of dose forms. Clinical signs vary depending on the agent, dose, and individual sensitivity. Should not be used for Brahman cattle nor regular application to calves less than 6 months of age.
Brahman cattle are less sensitive to the other organophosphates listed here.
CO-RAL is contraindicted for use in dairy goats during lactation and 14 days before parturition, on sick, convalescent, or stressed livestock, or on animals less than 3 months old. It must not be applied in conjunction with certain medications such as phenothiazine or other organophosphates, nor with pyrethrins. Wide variety of uses. Flea collars are claimed to have 3 months duration of effectiveness. Other cholinesterase inhibitors should not be sued on animals with the collars.