There are a lot of things you can do in other media that you cannot do in comic strips. There are also a lot of things that you can do in comic strips which you cannot do in other media. Use these to your advantage. There are a lot of things in comic strips that can't be transcribed to other mediums. Use these to your advantage.
Delivery is what makes the worst web strips mostly unreadable and the good ones so good.
Art is also an important part of delivery. The real test of a strip is how good it is without a joke. It may be a coincidence, but I think that the numbers out there support me. They all had enthralling plots. It was a national event with Dagwood and Blondie got married.