A range of other clinical manifestations you see. And the key labs here are that immunoglobulins are low, like it is in A third one is common-variable immunodeficiency, also known as acquired agammaglobulinemia. B-cells essentially just stop working. Most often the age of onset is after five years of age. So this is one, if you send your screening IgG, total IgG is going to come out normal, and what you need to look at in these kind of cases, if you suspect an antibody disorder, is to get IgG subclasses.
Clinical features are really pretty similar to X-linked agammaglobulinemia.
It is, unlike the other ones that we have been talking about, this is a B and T-cell defect. The chief findings that you will see here is severe and very early presentation of severe viral and bacterial infections. Onset may be as early as two to three months, which is earlier in general than X-linked agammaglobulinemia and may present a clue. There is failure to thrive, a progressive downhill course, a whole range of other clinical symptoms. This is an important one because it has a fairly classic pattern of presentation.