I doubt it very much if anyone would notice the speed change between these two compiler settings. Compress your code. The advantage in this is that the load time to fetch a file from disk is much longer than the time the computer needs to decompress the file. This means faster startup as well as smaller code. So the more resources like bitmaps, dialogs, fonts, etc.
Compression is fairly simple to use.
But compression is really something you should try. There are more techniques like using Wrapper functions and realigning code pages. We'll look at those some other time because they need a lot more explaining. Right now we'll take a look at the effects of some of the settings. As an example program I used the calculator we build last months.