Clinical experience suggests that in psychotic children, administration of amphetamine may exacerbate symptoms of behavior disturbance and thought disorder. Amphetamines are excreted in human milk. Mothers taking amphetamines should be advised to refrain from nursing. General Caution is to be exercised in prescribing amphetamine for patients with mild hypertension. The least amount feasible should be prescribed or dispensed at one time in order to minimize the possibility of overdosage.
Amphetamines can cause a significant elevation in plasma corticosteroid levels.
This increase is greatest in the evening. Amphetamines may interfere with urinary steroid determinations. Embryotoxic effects were not seen in New Zealand white rabbits given the drug in doses 7 times the human dose nor in rats given 12.5 times the maximum human dose. There are no adequate and well-controlled studies in pregnant women. Amphetamines should be used during pregnancy only if the potential benefit justifies the potential risk to the fetus.