Patients exhibit some jitteriness and overstimulation usually when the effects of the drug begin to wear off. Immediate gastric lavage may be beneficial if performed soon after ingestion of nitrazepam. Respirations, pulse and blood pressure should be monitored. General supportive measures aimed at maintaining cardiopulmonary function should be instituted and administration of i.v. fluids started. Hypotension and CNS depression are managed by the usual means.
Dialysis is usually of little value.
The reversal of the benzodiazepine effect could induce convulsions in such patients. Treatment should be as short as possible, and should usually not exceed 7 to 10 consecutive days. Use for more than 2 to 3 consecutive weeks requires complete re-evaluation of the patient. Dosage should be individualized for maximal beneficial effect. The usual adult dose is 5 or 10 mg before retiring.