It takes a bit more than one hour from Santiago, the fares are around 100 USD one way. The national carriers are Lan Chile, Ladeco, Alta and Avant. You can hire cars at the airport, prices start at 50 USD per day for the smallest ones. Bicycle, Motorbike, Car Villarrica is 764 km south of Santiago. It's paved the entire way of 3353 km from Arica in the North down to Quellon on Chiloe Island.
Cyclists can use the narrow and often poorly paved shoulder on each side of the road.
There is heavy traffic around Santiago and the bigger cities, but otherwise it's not too bad. Great parts of the Panamericana are being extended to four lanes. The trip takes three days and four nights and can be either spectacular or horrible, depending on the weather. While most of the journey is along fjords and between islands, for 16 hours the ship meets the open sea. This can be very rough and you might get sea sick.