Slow absorption usually increases the latency period. Increased dosage usually decreases the latency period. A drug s half life is the time for the drug s maximum concentration to drop by half. Generally due to metabolization and excretion. F. Variability refers to fact that a given dosage will vary in effect across individuals.
Allergic reactions are an example of hyper-sensitivity.
Hyper-reactivity is another form of overreaction to a drug. These varied responses to a drug explain need for medical monitoring. G. Tolerance refers to a decrease in drug effect after repeated administrations of the same dosage. Different forms of tolerance. Metabolic tolerance occurs when liver enzymes are induced by repeated use of a drug.