Basic principles of pharmacology, including receptor mechanisms, membrane phenomena, drug distribution and metabolism and pharmacokinetics. Lectures, laboratories, and tutorials on the interactions of drugs and biological systems as a basis for rational disease therapy. Lectures and tutorials on the interactions of drugs and specific organ systems, and on recent advances in molecular pharmacology. Staff Selected aspects of toxicology.
Content differs each time the course is offered.
May be repeated for credit. Molecular mechanisms of drug and chemical action. Gene regulation in metabolism, receptor activity, signal transduction, and cellular stress responses. Molecular mechanisms of DNA sequence alteration and repair. Oncogenes, tumor suppressor genes, and metastasis suppressor genes.