Begin 30 minutes before chemotherapy. Give only a single dose for each 24 hr period of emesis risk. PRN dosing is not permitted. Dose may be infused over 1 to 2 minutes. Give daily for each day of ondansetron.
Dexamethasone improves efficacy.
Avoid only if contraindicated or otherwise prohibited by protocol. Consult Pharmacy for alternatives to ondansetron if ondansetron cannot be used. Ondansetron 16 mg PO, begin 30 minutes before chemotherapy Give only 16 mg for each 24-hour period of emesis risk. PRN dosing is not permitted. Give only one 8 mg dose for each 24 hr period of emesis risk.