In addition to basic science understanding, an important goal of our overall research program is the identification and development of optimal synthetic lung surfactants and treatment protocols for use in patients, with final evaluations done in controlled clinical trials at the University of Rochester and other academic medical centers. Recent Publications Wright TW, Notter RH, Wang Z, Harmsen AG, and Gigliotti F. 2001. Pulmonary inflammation disrupts surfactant function during Pneumocystis carinii pneumonia. Notter, R.H. 2000. Knight, P.R., Kurek, C., Davidson, B.A., Nader, N.D., Patel, A., Sokolowski, J., Notter, R.H., and Holm, B.A. 2000.
Acid aspiration increases sensitivity to increased ambient oxygen concentrations.
Gernon, M.D., Turcotte, J.G., Notter, R.H., Mu, M., Lear, Y., Snelgrove, J.L., and Schwan, A.L. 1999. Kruger, P., Schalke, M., Wang, Z., Notter, R.H., Dluhy, R. A.,and Losche, M. 1999. I. Fluorescence and dark-field microscopy. Holm, B.A., Wang, Z., Notter, R.H. 1999. Multiple mechanisms of lung surfactant inhibition.