No 1 Morality should be based on the human capacities for reason, compassion, knowledge, and understanding. The universe has been brought about by a combination of randomness and history, chance and necessity.
All events have natural causes.
The universe is neither for us nor against us. Neither gods in the heavens nor stars in the sky fix our destinies. The scientific method is the most reliable way of acquiring knowledge. All knowledge is fallible and limited by uncertainty.