The intensity and frequency of incidence of these side effects is increased in the elderly. Paradoxical effects such as anxiety, insomnia, or even convulsions. Tolerance and physical dependence with chronic use of high doses, however this class of drugs has a relatively low abuse potential. Reproductive system effects. BZs cross placental barrier and are found in mothers milk.
Benzodiazepines have a relatively quite high therapeutic index.
It is very difficult to commit suicide with an overdose of benzodiazepines. Pharmacology of Barbiturates A. CNS effects of barbiturates 1. Remember thiopental as a intravenous anesthetic 2. Some barbiturates are potent anticonvulsants. Remember phenobarbital as a long acting anticonvulsant 3.