M.D. Johns Hopkins University School of Medicine , 1991. Internship in Internal Medicine, Duke University Medical Center Department of Medicine , 1991-1992.
Clinical studies are underway to correlate clinical features of the disease with NO expression.
Tissue culture studies involving the same patients are designed to determine potential cytokine regulation of NO expression and the effect of NO on apoptosis of peripheral blood mononuclear cells during different stages of disease activity. Recently, the laboratory has begun to investigate NO expression in patients with systemic sclerosis . The laboratory is also interested in the effects of a new class of drugs called selective COX-2 inhibitors. We are investigating the effect of selective COX-2 inhibition on renal function and pathology in murine lupus nephritis. I immunization-induced ACLS in naive animals.