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All anecdotal information is preliminary.
Usually two applications stops the swelling and pain. The chemical composition of toxins and the range of individual response to them would suggest that its doubtful that H3O will ever work as a universal treatment for all insect bites. Nonetheless, the responses we have received from users so far suggests that it will work to quickly reduce swelling and pain in a high percentage of users for the most common types of insect bites. Bites from these spiders caused large ulcers to form and massive secondary infections were common, most requiring surgery. One of these individuals had been previously bitten ten years earlier.