Once you do it, you won't regret it. As ertan commented, you need to determine if your users are going to have read-only abilities or if everyone is capable of changing the database at once. You can actually open your excel file in Access and Access attempts to translate everything for you. Sometimes you have to change your formatting in excel to get access to read the data correctly. Access also has the ability to create input forms so that it is very user friendly.
Access has wizards that make it fairly easy to use.
I am an Oracle DBA working in India currently. From what you have written, you would prefer to make the data on your worksheet mor global in nature. If this is the case, I would suggest you use Oracle8i rather than Access, since Oracle is far more effective. If you can give some details, such as how many people will be accessing this data,how many times, whether the access would be 24 hours a day etc., I will be able to help you in choosing between Personal Oracle and Enterprise Oracle and also to design your database. The name by which you'll be known in the forums.