One reason is that some patients have additional coexisting blood abnormalities, such as von Willebrand's disease. A specific factor XI assay is required for diagnosis. Treatments People with factor XI deficiency may need specific therapy for surgery, accident trauma and dental extractions. Several are available. They include fresh frozen plasma, factor XI concentrates, fibrin glue, antifibrinolytic drugs, and desmopressin.
Aminocaproic acid works well following tooth extractions.
Each has advantages and risks which should be considered. There is no commercially available factor XI concentrate currently licensed for use in the U.S. at this time. The plasma half-life of factor XI is approximately 80 hours. Complications Because the deficiency is so unpredictable, clinical management of it is difficult. Bleeding may occur days after a dental extraction or a surgery.