I certainly agree of the importance of midbrain, pontine and medullary mechanisms, which clearly do not simply evoke 'sham' emotions. I also support a top-down contribution. Here are some comments within the areas of my own expertise. ML involves disruption of long distance connections between the frontal lobe and the limbic system, for which there is no evidence in schizophrenia.
Dendritic spines are ephemeral structures and are continually being formed and removed.
So spine pruning is a normal event. This finding was confirmed by three other groups. Adrenochrome also produces behavioral and EEG disturbances in animals. The other catecholamine o-quinones derived respectively from dopamine and noradrenaline have never so been tested. Most attention in the field of the pathobiochemistry of schizophrenia has been focussed on dopamine.