In folate deficiency anemia , the red cells are abnormally large and are referred to as megalocytes, and in the bone marrow as megaloblasts. Subsequently, this anemia may be referred to as megaloblastic anemia Causes of the anemia are poor dietary intake of folic acid as in chronic alcoholism , malabsorption diseases such as celiac disease and sprue , and certain medications. A relative deficiency due to increased need for folic acid may occur in the third trimester of pregnancy . The incidence is 4 out of 100,000 people. Oral or parenteral folic acid supplements may be taken on a short term basis until the anemia has been corrected, or in the case of loss of absorption by the intestine, replacement therapy may be lifelong.
Dietary treatment consists of increasing the intake of green leafy vegetables and citrus.
Symptoms of anemia can cause discomfort. Call for an appointment with your health care provider if symptoms indicate anemia of folate deficiency may be present. Megaloblastic anemia can occur when there is a deficiency of vitamin B-12.