Treatment options depend on the type, size, location, and stage of the cancer, as well as the person's age and general health. Surgery is often the primary treatment. When appropriate, surgeons avoid amputation by removing only the cancerous section of the bone and replacing it with an artificial device called a prosthesis . Chemotherapy and radiation may also be used alone or in combination. Because of the tendency for Ewing's sarcoma to metastasize rapidly, multidrug chemotherapy is often used, in addition to radiation therapy or surgery on the primary tumor .
Clinical trials are a critical step in the development of new methods of treatment.
Before any new treatment can be recommended for general use, doctors conduct clinical trials to find out whether the treatment is safe for patients and effective against the disease. Various forms of cancer treatments using surgery, radiation therapy, and chemotherapy for bone cancer are being tested in clinical trials.