Animal bone is a combination of organic and mineral components.
One of the first reports of electromechanical behavior of living bone appeared in 1962. Studies, however, began in the early 40s, and speculation of the body's intricate system can be traced to the 1800s. Researchers found that by inducing selective electrical changes in the micro environment around and within cells, biological behavior could be modified. The original report, written by Andrew Bassett, set forth details of the generally asymmetric voltage wave forms produced by mechanical deformation and established features that were subsequently used in developing the MediMend V100. Initially, techniques used in healing bone fractures required the implantation of electrodes.