Determine developmental conseqeunces of gene defect in mice. Isolate full-length cDNA and use with ESTs to build contig. Use structure function analyses and cell transfection expts to study function. Establish a genetic model in plants, flies or mice. Determine the function of the encoded gene.
Biochemical process is characterized by a cell-based assay.
Isolate cDNA sequences by expression cloning. Isolate full-length cDNA and use with ESTs to build contig. Use structure function analyses and cell transfection expts to study function. Establish a genetic model in plants, flies or mice. A human genetic disease is mapped in a population.