The nuclei reside along the cell periphery. Each muscle cell is surrounded by a basal lamina and connective tissue . Skeletal muscle fibers are NOT joined by cell junctions. Skeletal muscle is innervated and highly vascularized due to its high energy requirements. The vessels penetrate the epimysium then branch to travel throughout the muscle in the perimysium and endomysium.
Connective tissue transmits the mechanical force of muscle.
Tendons connect muscle to bone. The myotendinous junction occurs at the end of the muscle cell where the terminal actin filaments connect to the plasma membrane. Muscle fibers develop from the fusion of many muscle precursor cells called myoblasts . Differentiation, which has been studied extensively, requires three events. Withdrawal from the cell cycle.