Signs show that the gene coding for the prion protein undergoes a spontaneous mutation. The gene then codes for the abnormal, infective form of the protein. A small number of mutant cells producing a small amount of prion protein can initiate a progressive infection. Recent research suggests that this occurs because the abnormal protein can transform normal molecules by causing them to change their configuration. Affected animals exhibit symptoms that include the loss of coordination and a staggering gait, as well as showing signs of senility, including lack of interest in their surroundings, the abandonment of routine habits, disinterest in feed and water, and unpredictable behavior.
Death is the final step.
There is NO cure for the disease.