Mice lacking MHC class II molecules. Mice lacking MHC class II molecules. We have produced mice that lack major histocompatibility complex class II antigens, permitting us to evaluate the role of these molecules in diverse aspects of T and B cell differentiation.
B lymphocytes occur in normal numbers and are capable of terminal differentiation to plasma cells.
In short, the class II-negative mice have confirmed some old ideas about lymphocyte differentiation, but have provided some surprises.