Binding Studies with Mutants of Zif268. Contribution of individual side chains to binding affinity and specificity in the zif268 zinc finger-dna complex. Design of polydactyl zinc-finger proteins for unique addressing within complex genomes. Improved DNA binding specificity from polyzinc finger peptides by using strings of two-finger units. Refined 1.8 A crystal structure of the lambda repressor-operator complex.
Conserved residues make similar contacts in two repressor-operator complexes.
Changing the binding s pecificity of a repressor by redesigning an alpha-helix. Crystal structure of the lactose operon r epressor and its complexes with DNA and inducer. Structure of a paradigm. Mechanism of specificity in the Fos-Jun oncoprotein heterodimer.