The major morbidity of recurrent or metastatic parathyroid cancer results from severe hypercalcemia, which can be difficult to control. However, control of malignant hypercalcemia with these medical measures is often only temporary. Anecdotal reports show that short-term remissions with chemotherapy are possible. As parathyroid carcinoma can be slow-growing, resection of local recurrences or distant metastases can bring effective palliation but rarely cure. Surgery plus radiation therapy.
Anecdotal reports show that short-term remissions with chemotherapy are possible.
Disodium pamidronate in the preoperative treatment of hypercalcemia in patients with primary hyperparathyroidism. Warrell RP, Israel R, Frisone M, et al. Intraoperative radiotherapy in patients with recurrent head and neck cancer. ReMine WH, et al. Cancer of the parathyroid glands.