Hypercalcemia, hypercholesterolemia, hyperglycemia, pre-renal azotemia, myopathy. There was mild, irregular epidermal hyperplasia accompanied by moderate, diffuse, spongiosis and multifocal epidermal necrosis. Multifocal intra-epidermal pustules were associated with multifocal, subepidermal vesicle and pustule formation. There was diffuse superficial dermal degeneration and necrosis associated with a moderate, perivascular to diffuse, mixed, predominately neutrophilic and plasmacytic, dermatitis and panniculitis. Extensive vascular degeneration and necrosis was evident within the dermis and there was pyogranulomatous thrombosis of deep dermo-hypodermal venules.
Cutaneous disease is an uncommon manifestation of clinical toxoplasmosis in both humans and cats.
A review of 100 cases of clinical toxoplasmosis in cats identified only two cats with cutaneous toxoplasmosis. Toxoplasmosis in cats is usually characterized clinically by fever, dyspnea, polypnea, anorexia, lethargy and abdominal discomfort. The histological changes described in feline cutaneous toxoplasmosis are a toxoplasmic vasculitis and associated infarction. Acute toxoplasmosis in humans is usually characterized by isolated, asymptomatic lymphadenopathy without a rash. Histologically, varied combinations of vasculitis, perivasculitis, necrosis, periadnexal inflammation, and rare granulomas have been described.