This is usually obtained by the Draize test, a test that uses rabbits. However, due to concerns over animal welfare, it has been suggested that alternative methods may be used if they are proved to be appropriate as substitutes for the method presently employed. Several in vitro methods have been examined, of which some have correlated well with the results of the Draize test. However, non one test has been able to reliably predict the results of Draize test over the full range of test substances. This guidance describes a scheme that uses alternative methods in combination with the Draize test in order to reduce the number of animals required for testing and minimize the suffering of the animals without lowering the reliability of evaluation of the eye irritation potential of cosmetic raw materials.
Alternative methods constitute only a part of the evaluation scheme.
This is because experience of the utilization of those methods in actual situation seemed insufficient. As further test results are accumulated by testing many cosmetic raw materials by both the Draize test method and alternative methods in accordance with this guidance, revisions to the guidance may be necessary. The appraisal scheme outlined in this guidance does not necessarily require the same procedure for every substance or at all testing facilities. The emphasis is on selecting the appropriate method according to the purpose of the test, properties of the test substance, experience and equipment available in the testing facilities, etc., while taking into consideration the following points. As cosmetics are used in daily by ordinary people, safety of the products is of great importance.