Physical and emotional stressors can result in behavioral adaptation.
Adaptation is regulated through the endocrine system.
During stress CRH and another local mediator AVP, stimulate ACTH and cortisol secretion. Other factors can also be recruited in various types of stress, they include angiotensin II, cytokines and lipid mediators of inflammation. There are also differences in response to different magnitudes of the same acute stress. In chronic stress, such as in experiments which impair circadian HPA rhythms, even the normal correlations between ACTH and cortisol levels can tee lost. Much of the current understanding of HPA related stress responses ie.