Layout at best will be lost when translated by verbal browser or screen reader. At worst it will cause confusion and error. The same is true of cutting edge technology. Most screen readers and browsers in use today by blind users can't even handle Java script. It sounds strange to say, but stick with obsolete technology.
Blind users are a small, specialized group.
By the time a technology is converted for their use, it is no longer cutting edge. The simpler sites work better for most screen readers and browsers. Be very careful if you are using one of the commercial html generators. Most of these have foibles that make their output virtually incomprehensible to the screen readers currently in use. Make use of lists, like the unordered list that follows.