Julie E. Davis, PharmD Barbara Kaplan-Machlis, Pharm. Sevelamer is supplied as 403 mg hard gelatin capsules. The recommended starting dosage is two to four capsules with each meal, depending on the severity of hyper-phosphatemia. In clinical trials, the average dose was three to four capsules per meal. The maximum dose studied was 30 sevelamer capsules per day.
Costs are an average of cost to patient obtained from three local pharmacies.
Therefore, caution should be exercised when using sevelamer in patients with these disorders. Sevelamer is contraindicated in patients with hypophosphatemia or bowel obstruction. It is also contraindicated in patients known to be hypersensitive to sevelamer hydrochloride or any of its components. However, there are no studies of the effects of sevelamer on vitamin absorption in pregnant women. There are no adequate, well-controlled studies in nursing mothers.