The run-in time is essentially the same for all cables. However, the apparent need for run-in varies wildly. As with amplifiers and other components, the better the cable, the less distortion it has, and therefore the less there is to cover up the obnoxious distortion caused by being new. Since human perception is more aware of the existence of a distortion than the quantity, the better the cable, the worse in some ways it will sound when new, because the anemic forced two-dimensional effect reulting from being new will not be ameliorated by other gentler distortions. Please be patient when first listening to any superior product.
All cables are directional, from hardware store electrical cable to the finest pure silver cables.
All AudioQuest cables are marked for direction. The difference will be clear-in the correct direction the music is more relaxed, pleasant and believable. While cable directionality is not fully understood, it is clear that the molecular structure of drawn metal is not symmetrical, providing a physical explanation for the existence of directionality. This type of speaker has one input for the woofer and a separate input for the upper frequency ranges. Maybe it is worth spending twice as much on cable in general, but that's a separate question.