The upper respiratory tract, lungs, and skin are common sites of infection. The incidence is approximately 1 out of 100,000 people. Genetic counseling may be offered to prospective parents with a family history of agammaglobulinemia or other immunodeficiency disorders . Frequent infection may begin early or later in life. High doses of high titer gammaglobulin are needed for severe infections.
Antibiotics are available for the treatment of bacterial infections.
Treatment with immune globulins has improved the health of people with agammaglobulinemia. Without treatment, most severe infections are fatal.