Based on the exon structure of their genes as well as the configuration of the sequence domains of the proteins they can be divided into several families or groups. All collagenous proteins have domains with a triple-helical conformation. Thus harsh treatments such as paraffin embedding or boiling for standard western blots often destroy the epitopes recognized by antibodies to collagens because the structural epitope has been altered. Therefore, for the majority of our Collagen antibodies, they do not react on paraffin sections or in standard western blot procedures. Shine for a moment.
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