This is a real clinical problem. It is a genetic deficiency in the leukocyte adhesion proteins. It results in recurrent bacterial infections. All granulocytes, monocytes and to a lesser extent lymphocytes respond to chemotactic stimuli. Both exogenous and endogenous substance can act as chemoattractants.
Bacterial products are an example of an exogenous chemoattractant.
The increase in intracellular calcium triggers the assembly of contractile elements responsible for cell movement. Leukocytes move by extending a pseudopod which pull the rest of the cell in the direction of the extension. The pseudopod contains the proteins actin and myosin, as in muscle. Motion involves rapid assembly, contraction and disassembly of a contractile apparatus by the cells. Phagocytosis Phagocytosis and the release of enzymes by neutrophils and macrophages are two of the major benefits of the inflammatory process.