It is unknown how mitochondrial mutations cause their damage. Studies are directed towards understanding this as well as simplifying mutation detection strategies of this genome. Heart Disease - P Bray Dr Bray has discovered the cause of uncontrolled growth of cells to block arteries as mutations in the TGF beta R2 receptor. Dr Bray is currently examining the Glucocorticoid Receptor for a similar causative role. Mutation Databases - O Horaitis, R Cotton Dr Cotton has initiated the HUGO Mutation Database Initiative to capture all mutations in genes and to ensure their distribution.
Coordination involves approximately six hundred people in thirty four countries.