Without this spice, Bene Gesserit Reverend Mothers could not perform feats of observation and human control, Guild Navigators could not see safe pathways across space, and billions of Imerial citizens wo uld die of addictive withdrawal.
Any simpleton knows that such dependence upon a single commodity leads to abuse.
We are all at risk. We are generalists. You can't draw neat lines around planetwide problems. 1 Thou shalt not make a machine in the likeness of a human mind. The Guild monopoly on space travel and transport and upon internation al banking is taken as the beginning point of the Imperial Calendar.