Affected females also frequently have a concurrent subclinical mastitis. Appel, M.J., Yates, R.A., Foley, G.L., Bernstein, J.J., Santinelli, S., Spelman, L.H., Miller, L.D., Arp, L.H., Anderson, M., Barr, M. Canine Distemper Epizootic in Lions, Tigers and Leopards in North America. 2nd edition, Academic Press Inc., San Diego, CA, pg. Retinoblastoma cells in a mouse. Several mice of the above strain presented with unilateral proptosis.
All mice have bilateral cataracts.
The eye was red-brown and solid. No extraocular structures appeared to be involved grossly. There are numerous normal and bizarre mitotic figures and large foci of necrosis within the body of the mass. In some sections, extension of neoplastic cells into the optic nerve can be seen and in other sections, the degenerate lens is seen. The FVB line 19 was a transgenic mouse developed to aid in research into human cervical cancer.