Anderson never married. They had one son, George McNutt. Dr. Anderson founded Southern and Western Theological Seminary, later known as Maryville College in 1819. Both are buried in New Providence Church Cemetery in Maryville, Knox County, Tennessee. Samuel Anderson married Betty Burris.
Any children are unknown.
They had four children, names unknown. They had one daughter, Martha Ann McCampbell. They had seven children, names unknown. In 1893, he married Fannie McNabb. In 1890, she married James M. Crawford.