Let's think about what happens when organs are damaged by disease. The links I've included here are graphic. If they bother you, don't access them. However, they point out very dramatically that there are many ways to damage our tissues. Cirrhosis affects the liver.
Blunt force can also cause liver damage.
Skin is the largest organ in humans. Here is the effect of fungal abscess on the lung. Normal kidney Atherosclerotic Aneurysm of kidney causing atrophy. Gangerene in a diabetic. D. Organ systems involve multiple organs which cooperate to carry out major tasks such as reproduction or circulation.