Gastrointestinal bleeding is associated with higher morbidity and mortality in patients acutely ill with other conditions, the elderly and patients with hemorrhagic disorders. This medication may decrease response to antihypertensives or diuretics. May increase serum levels and risk of toxicity from lithium. May increase the risk of hematologic effects from chemotherapy medications and radiation. It may increase the risks of adverse renal effects with gold compounds, cyclosporine or chronic use of Tylenol.
Antacids decrease blood levels and decrease the effect of sulindac.
It may increase the risk of light sensitivity and reactions with other photosensitizing medications. May increase the risk of hypoglycemia with insulin or oral hypoglycemic medications. The maximum dosage is 400 mg per day. Tinnitus, blurred vision. Underlines indicates most frequent.