Systemic refers to a site of action other than the point of contact and presupposes absorption has taken place. For example, an inhaled material may act on the liver. Cumulative poisons are characterized by materials that tend to build up in the body as a result of numerous chronic exposures. The effects are not seen until a critical body burden is reached. This is called a synergistic or potentiating effect .
Age can affect the capacity to repair tissue damage.
Previous exposure can lead to tolerance, increased sensitivity, or make no difference. State of health, physical condition and life style can affect the toxic response. Preexisting disease can result in increased sensitivity. Environmental factors such as temperature and pressure are factors, as are host factors including genetic predisposition and the gender of the exposed individual. All rights reserved.