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Affected cells appear swollen and contain clear vacuoles.
These may coalesce to form a large single vacuole which displaces the nucleus to the edge of the cell and causes the cell to resemble an adipocyte. This is a reversible process. Fat is removed on routine processing and hence appears as an empty space. Oil Red O. The following sections are taken from the liver of a cow 2-3 weeks after calving. She developed metritis and pneumonia and at post mortem had a large swollen, pale, greasy liver.