These antibodies probably trigger the cells to release histamine, which causes a hive. There are no commercially available tests to find out if a patient has autoimmune urticaria, but the tests can be done on an experimental basis at certain research centers. We do not currently know of any easy way to get rid of these antibodies, so for now, these patients are treated in the same way as any other patient with chronic idiopathic urticaria. However, future research may lead to the discovery of a new way to treat these patients who have autoimmune antibodies that cause urticaria. In cases where a trigger can be identified, the best way to treat the urticaria is by avoidance of the trigger.
Antihistamines are the most helpful.
Some of the newer prescription antihistamines can help without causing any side-effects. However, in severe cases that do not respond to the usual medicines, long-term treatment with low doses of steroids can be considered.