That's because it isn't a drug concocted in a chemistry lab. It's a natural substance found in virtually every cell of the body. SAMe is indispensable for health and longevity. It's crucial for the synthesis of neurotransmitters, DNA, RNA and phosphatidylcholine, which keep cell membranes in a youthful state. It contributes to the synthesis of polyamines which regulate protein synthesis, and may play a key role in energy production.
Beta blockers suppress serotonin as well as melatonin.
Thus, it is not surprising that the Physicians Desk Reference lists mental depression, fatigue, short term memory loss, insomnia and emotional lability as some of the side effects of Inderal and other beta blockers. This is an important discovery because it was previously assumed from studies on blood cells that AD patients had too much SAMe. Proper studies have never been done with SAMe as a treatment for Alzheimer's disease because of this erroneous assumption. The natural synthesis of melatonin during the night is dependent on the synthesis of SAMe during the day. SAMe is necessary for the biochemical reaction that converts serotonin into melatonin.