This is useful in helping the body to get rid of excess potassium. Aldosterone production is normally controlled by a negative feedback system. Angiotensin II has several functions. In this context, angiotensin II stimulates the adrenal gland to produce aldosterone. High potassium levels in the blood can also directly stimulate aldosterone production by the adrenal gland.
Aldosterone then acts on the kidney to make it retain sodium and water, and to get rid of potassium.
As the initiating abnormality is corrected, renin production and aldosterone production decreases. In primary aldosteronism, the adrenal gland fails to respond to the normal controls and produces more aldosterone than is required. This results in excess sodium retention, which raises the blood pressure. This commonly affects both adrenal glands. Development of a tumour of the aldosterone-producing cells of the adrenal gland.