The male prostate gland has 100 times more acid phosphatase than any other body tissue. When prostate cancer spreads to other parts of the body, acid phosphatase levels rise, particularly if the cancer spreads to the bone. Levels fall after the tumor is removed or reduced through treatment. Tissues other than prostate have small amounts of acid phosphatase, including bone, liver, spleen, kidney, and red blood cells and platelets. Damage to these tissues causes a moderate increase in acid phosphatase levels.
Acid phosphatase is very concentrated in semen.
Rape investigations will often include testing for the presence of acid phosphatase in vaginal fluid. This is not a screening test for prostate cancer. Acid phosphatase levels rise only after prostate cancer has metastasized. Description Laboratory testing measures the amount of acid phosphatase in a person's blood, and can determine from what tissue the enzyme is coming. For example, it is important to know if the increased acid phosphatase is from the prostate or red blood cells.