In these cases data will accumulate for some time after the end of recruitment and a final analysis can incorporate the extra data. Therefore, in addition to delaying the final analysis, such an approach will provide a higher power than was specified for the sequential design. This project will address the analysis issues and explore possibilities of stopping recruitment earlier, to enable the power requirement to be fulfilled more efficiently. The prediction of trial duration will be investigated. In addition, the impact on the final analysis of releasing information from an ongoing study will be considered.
Data sets are available from completed sequential trials.
There will be contact with statisticians and clinical research personnel from pharmaceutical companies to discuss the practical application. Biopharmaceutical Sequential Statistical Applications. The Design and Analysis of Sequential Clinical Trials. Revised second edition.