Mitochondria have an enzyme that helps them multiply. It is very similar to HIV's reverse transcriptase enzyme. Unfortunately, this means that the drugs we use to inhibit reverse transcriptase can also inhibit pol gamma. When this happens, fewer new mitochondria are produced. MT is more likely to occur the longer you take these drugs.
Different medications concentrate in different organs of the body.
This could be why MT caused by different drugs damages different parts of the body. Unfortunately, there is very little research on how much mitochondrial damage each antiviral drug causes to different parts of the body. Unfortunately, there is very little research on MT caused by nukes. Laboratory and animal studies show that MT can cause nerve damage. But there are no human studies.