Without this spice, Bene Gesserit Reverend Mothers cound not perform feats of observation and human control, Guild Navigtors could not see safe pathways across space, and billions of Imperial citizens would die of addictive withdrawal.
Any simpleton knows that such dependence upon a single commodity leads to abuse.
We are all at risk. As the armored 'thopter flew high overhead, the white sun of Arrakis dazzled against unrelenting sands. The sweeping vista of dunes sizzling in the day's heat made his retinas burn. The landscape and sky were bleached of color. Nothing soothed the human eye.