Drug Targeting and Delivery in Cancer Chemotherapy and other conditions. However the natural material is difficult to isolate and has low stability, to circumvent these problems a synthetic LDL has been prepared which is LDL receptor competent and stimulates cell growth in vitro . Current research is aimed at employing sLDL as a growth factor in serum free tissue culture media and identifying the parameters controlling biological properties. In this Department, research has been conducted into the possible use of particles coated with bacterial adhesion molecules such as integrin. The particles can be prepared and maintain biological activity although physicochemical properties are altered.
Current research is aimed at refining the attachment procedure prior to further biological testing.
Initial research is aimed at fully characterising the material and conducting pre-formulation studies to determine solubility, stability and suitable analytical methods. A formulation and method of manufacture will then be sought and optimised for toxicity testing and clinical trial. Long term stability studies on the formulation and raw material will also be conducted. Since the compounds are derived from a variety of sources and posses a diversity of pharmaceutical properties, a wide range of formulations have been produced, ranging from simple injectable solutions to parenteral emulsions and liquid fill capsules. The Unit has a licensed manufacturing facility for small volume parenterals and conducts all studies under Quality Assurance guidelines.