This results in cholesterol esters that are deposited in storage droplets. The cell adjusts its receptors so only enough cholesterol is brought in to supply its needs. With Familial Hypercholesterolemia, an inhereted mutant gene causes the absence of LDL receptors. Consequently, Familial Hypercholesterolemia leads to high blood cholesterol and heart attacks in the young. Exogenous fat transport begins in the intestine where dietary fats are packaged into lipoprotien particles called chylomicrons.
Chylomicrons enter the bloodstream and deliver their triglyceride to adipose tissue and muscle.
The remnant of chylomicrons is removed from the arculation by the liver. Half of the IDL particles are removed from circulation by the liver within two to six hours of their formation.