May Cause Visual Side Effects Pre-Enucleation Radiation for Large Choroidal Melanoma Has No Effect on Mortality Photodynamic therapy approved for ocular histoplasmosis syndrome. Click here to learn more. Click here to learn more about this exciting new treatment.
Choroidal melanoma is the most common primary intraocular malignancy in adults.
Although removal of the eye for large tumors has been the accepted treatment for decades, questions remain about the possibility of enucleation promoting distant metastases. Some have therefore suggested pre-enucleation radiation of the tumor in hopes of preventing metastasis. The COMS thus concluded that mortality rates following 125 I brachytherapy did not differ from mortality rates following enucleation for up to 12 years after treatment of patients with choroidal melanoma. HSV can result in scarring of the cornea and vision loss, particularly with stromal keratitis. The Herpetic Eye Disease Study Group, a randomized, double-masked clinical trial, investigated the effect of oral acyclovir therapy for recurrences of HSV epithelial keratitis and stromal keratitis.