The unexpected observation of an increased mortality from non-natural causes, in clinical trials aimed at reducing cardiovascular mortality by lowering cholesterol, has led to speculation as to the possible psychiatric risks of low or lowered serum cholesterol. Cholesterol is ubiquitous, but is especially abundant in the central nervous system, where it plays important roles in the fluidity of cell membranes, in membrane permeability and exchange processes, and as a precursor for steroid hormones.
Cholesterol is transported in the plasma bound to proteins called lipoproteins.
Also, since lipid metabolism involves adrenergic mechanisms, stress and anticipatory anxiety can lead to increases in cholesterol levels. These factors must be taken into account in studies assessing cholesterol levels. View the complete article.