His current research is directed towards defining the level of control exerted by perivascular nerve fibres over endothelium-dependent relaxation, and to determining the mechanism by which the nerve fibres exert their influence. This work is being carried out using the rat superior mesenteric artery as a model, using the techniques of isolated tissue pharmacology, immunohistochemistry and electron microscopy. The flow of blood to the tissues is determined by the pressure in the system and the resistance of the blood vessels. Innervation is one of the main determinants of resistance through its control of blood vessel diameter. Using video microscopy, Dr. Scott is investigating how the nervous system controls the distribution of resistance in blood vessel beds with a view to a greater understanding of how this changes in cardiovascular diseases such as atherosclerosis and hypertension.
Atherosclerosis is one of the major cardiovascular diseases.
While many factors are thought to contribute to its development, its cause is not known. Dr. Scott is investigating the part played by perivascular nerve fibres in the initiation of atherosclerosis development. Using rabbits as an experimental model, blood vessels are denervated and the animals fed a high fat diet. Using video microscopy, pharmacology and electron microscopy, it will be determined to what extent nerves are involved in the pathogenesis of atherosclerosis. Damage to the digestive system caused by periods of poor blood supply is a significant problem which in severe instances may lead to failure of other organs and death.