Our bare hand stung smartly, and another round or two brought out the PAST glove which really didn't help all that much. Next came a full charge 158 gr. While it didn't seem quite as sharp as the 125 gr. load, it was still too much. The vaunted 125 gr. The point here is that ammunition selection is critical.
Accuracy beats power every time.
The optimum choice would be the medium velocity loads, but tolerance levels vary, and each shooter must find the hottest load with which you can still maintain comfort and reasonable combat accuracy. With the hottest stuff, only the best trained can manage more than a few shots before they begin to flinch. That's the real breaking point. The scandium revolvers may carry a similar warning. But the warnings are sometimes misunderstood.