Using Microdialysis Probes and Robotic Blood Sampling.
Bioanalytical chemistry is crucial to gaining an understanding.
Samples must be taken and compounds must be quantitated, including the drug substance and any metabolites, as well as endogenous substances the drug candidate might influence. This presentation will illustrate this integrated approach in which liquid chromatography, mass spectrometry, and electrochemistry are coupled to sampling in a more automated fashion than was possible even a just a few years ago. Components of the approach also include 96-well SPE, the Raturn animal containment system, the Culex robotic blood sampler, and epsilon microbore liquid chromatography. Peter Kissinger received his B.S. from Union College in 1966 and his Ph.D. from the University of North Carolina in 1970. After spending time at the University of Kansas and Michigan State University, he moved to Purdue and later founded Bioanalytical Systems, a pharmaceutical development company doing contract research and supplying products for medical research.