Each minocycline hydrochloride capsule, for oral administration, contains the equivalent of 50 mg or 100 mg of minocycline. Skin and skin structure infections caused by Staphylococcus aureus . In severe acne, minocycline may be useful adjunctive therapy. This drug is contraindicated in persons who have shown hypersensitivity to any of the tetracyclines. Enamel hypoplasia has also been reported.
All tetracyclines form a stable calcium complex in any bone-forming tissue.
This reaction was shown to be reversible when the drug was discontinued. Evidence of embryotoxicity has been noted in animals treated early in pregnancy. While this is not a problem in those with normal renal function, in patients with significantly impaired function, higher serum levels of tetracycline may lead to azotemia, hyperphosphatemia, and acidosis. If renal impairment exists, even usual oral or parenteral doses may lead to excessive systemic accumulations of the drug and possible liver toxicity. Under such conditions, lower than usual total doses are indicated, and if therapy is prolonged, serum level determinations of the drug may be advisable.