It is rapidly absorbed from the proximal small intestine. It is extensively distributed in the body. It is metabolised in the liver. It is transformed to clinically active metabolites.
Clearance is reduced in liver damage.
It produces a brief initial phase of strong action followed by prolonged milder effect due to a two phase plasma concentration decay curve. Indications Diazepam is used to relieve nervousness or anxiety. It is preferred in acute panic states and anxiety associated with organic disease. It is used in the treatment of insomnia . Diazepam, is also used to help relax muscles or relieve muscle spasm.