It is harder to make any real changes in larger, more established businesses. In fact, it is exactly the opposite. The reason large organizations are easier to transform lies in the theory of complex adaptive systems.
Complexity theory explains how a small change affects all parts of the system.
Significant changes can be accomplished with minimal effort and small disturbances to the system. Of course, this holds for profitable and unprofitable changes. It will probably take more time to transform an organization with 1,000 people than one with 10 people, but the difference cannot be scaled linearly in a direct proportion. If this were true, it would imply that large organizations were considerably less intelligent than small ones, and it is unlikely they could survive and adapt. This does not match with the reality of their persistence.