The New England Journal of Medicine reports that people with osteoporosis who received fluoride had an increased rate of nonvertebral fractures. The U.S. National Research Council states that the U.S. hip fracture rate is now the highest in the world. Several studies link fluoride to genetic damage and cancer. As reported in Mutation Research, an unpublished study by Proctor and Gamble, the maker of Crest toothpaste, showed that 1 ppm of fluoride causes genetic damage. Other journals have noted a link between fluoride and genetic toxicity.
Bone is the target organ for fluoride.
I believe EPA should act immediately to protect the public, not just on the cancer data, but on the evidence of bone fractures, arthritis, mutagenicity, and other effects. The process of fluoridating water also presents the risk of a toxic overdose. The CDC has recorded several cases in which excessive amounts of fluoride entered the water supply and sickened or killed people. These incidents may not make the headlines, but citizens have learned about them from data obtained under the Freedom of Information Act. Three dialysis patients died and five had toxic reactions to the fluoridated water used in their treatment process.