Fryns and Pallister-Killian syndromes share some common characteristics. Cloudy corneas, retinal dysplasia, hypertelorism, protruding eyes, strabismus, glaucoma, and narrow palpebral fissures. Cleft lip and palate, macrostomia, and short upper lip. Hypoplastic nipples, small thorax, and thin and supernumerary ribs. Brachytelephalangy, broad terminal phalanges, camptodactyly of the fifth fingers with deviation of other fingers, and talipes equinovarus.
Dermatoglyphic findings consist of a single transverse palmar crease.
Intestinal malrotation, esophageal atresia, duodenal atresia, imperforate anus, and bowel agangliosis. Transmitted as an autosomal recessive trait.