Methyl testosterone is not testosterone. It is a chemical analog of testosterone and is more toxic than testosterone. Prednisone or methylprednisolone are not cortisol or hydrocortisone. They are synthetic analogs of cortisone and are more toxic than the natural corticosteroids. All substances, organic or inorganic, are chemicals.
Air is a mixture of gaseous chemicals.
In all mammals, including humans, progesterone plays an important part in the reproductive cycle. But both natural and synthetic progesterones can enhance hormonal balance or suppress reproduction, depending on the size and timing of the dose. Natural progesterones were isolated by Russell Marker, of Pennsylvania State College, in the 1930s. While experimenting with a type of plant steroid, called sapogenins, Marker realized that progesterone could be derived from one sapogenin, disogenin, found in this plant. Most of what we know about progestin use during menopause was learned from oral contraceptives.