Follicular epithelium is hypertrophic and vacuolated. Follicle colloid is globular and sparce. Somewhat serpentine arrangements of arteriolar smooth muscle cells represent portal arteriolar hyperplasia. Portal veins are not discernable. Scattered hepatocytes contain brown pigment.
Central veins are inconspicuous.
Kupffer cells contain abundant pigment. Reticulin stain demonstrates increased sinusoidal reticulin extending from portal to centrilobular areas of the liver. This magnification shows abundant reticulin and individualization of hepatocytes. Blue staining areas localize collagen. There are multiple coalescing foci of myocardial cell degeneration, necrosis, edema, and an inflammatory cell infiltrate.