Lymph glands of the neck may develop singly or in chains. They become swollen painful and may have a rubbery texture. They may break down to give abscess formation. These may discharge onto the skin giving a very unsightly combination of swelling a pus around the neck. This was the old fashioned scrofula, which was said to be cured by a touch from the King.
Bony disease causes pain and swelling of the affected part.
Spinal disease may cause paraplegia if enough of the vertebrae are destroyed to cause instability of the spine. Abdominal disease characteristically causes pain and constipation. If advanced it may cause complete obstruction of the bowel. A single cranial nerve my be affected resulting in double vision. There may be mental confusion developing over days or weeks.