If these drugs must be used during pregnancy, the potential risks should be discussed with the patient. Babies born to women receiving large doses of corticosteroids during pregnancy should be monitored for signs of adrenal insufficiency and appropriate therapy initiated, if necessary. This probably reflects the fact that cortisone is more commonly used during pregnancy than is prednisone and therefore, more reports of problems have been associated with cortisone than prednisone and not the fact that it is a more potent teratogen. Corticosteroids distribute into breast milk, and the manufacturer states that women receiving pharmacological dosages of corticosteroids should not practice breast-feeding. Methylprednisolone is quickly distributed into the kidneys, intestines, skin, liver, and muscle.
Corticosteroids cross the placenta.
Br J Obstet Gynaecol . Neonatal Ed . Am J Obstet Gynecol . Corticosteroid therapy in hyperemesis gravidarum T. Murphy Goodwin Experience with oral methylprednisolone in the treatment of refractory hyperemesis gravidarum. The use of methylprednisolone versus antiemetics in the treatment of hyperemesis gravidarum.