For most patients with illness of mild to moderate severity, a starting daily dose of 75 mg is recommended. Dosage may subsequently be increased or decreased at appropriate intervals and according to individual response. In patients with very mild symptomatology or emotional symptoms accompanying organic disease, lower doses may suffice. This dose may be given at bedtime. The 150 mg capsule strength is intended for maintenance therapy only and is not recommended for initiation of treatment.
Antianxiety effect is apparent before the antidepressant effect.
Optimal antidepressant effect may not be evident for two to three weeks.