With this increased oxygen use there is an increase in a production of vasodilator substances, which increases blood supply. With the oxygen demand theory, oxygen is required to maintain vascular contraction. When oxygen level decreases, dilatation of the blood vessels occurs. This increases blood flow. With autonomic regulation of the vessels, adrenergic sympathetic nervous system regulation secretes norepinephrine at the nerve endings, which produces vasoconstriction.
Arterioles help to regulate blood flow and arterial pressure.
Veins help to regulate the amount of blood flow. Vasoconstriction causes the increase in venous return to the heart. The parasympathetic nervous system secretes acetycholine at the nerve ending producing vasodilation. Stretch receptors or baroreceptors are located at the aortic arch, carotid sinus, vena cava, pulmonary arteries, and atria. They are activated by elevated blood pressure usually greater than 60 millimeters hg. or blood volume.