Carriers of this mutation have no symptoms of the disease. By having your Shetland sheepdog tested, you can prevent this. Carriers can be bred to animals that are clear of the mutation. The next generation of breeding will produce some animals that no longer carry this mutation. It is believed that Shelties may also have type I vWD, a milder form of the disease.
Affected animals die as puppies, but carriers of the mutation are completley normal.
By testing your Portuguese water dog for this mutation, you can prevent, affected puppies from being born. You keep your clear pick for the next generation of breeding. Inherited phosphofructokinase deficiency in an American cocker spaniel. Molecular basis of canine muscle type phosphofructokinase deficiency. The molecular basis of canine pyruvate kinase deficiency.