Experiments have not yet validated that autoimmunity can destroy normal prostate. They can immunize with xenogeneic human PAP in rats and get peptide and protein specific responses to self antigen. There is also an antibody response. But prostatitis does not occur. Immunization to PSBP induced strong IgG and Th responses.
Destructive prostatitis is observed in some rats.
This does not occur in all rats and also does not result in complete prostate destruction. He believes that there is ignorance of this protein. One can get prostatitis if express PSBP at abnormal place and time. PSBP is not found in humans. Prostates are different from one species to another.