Diabetics have low levels of glucokinase, so supplementing with high dosages of biotin can improve their glucose metabolism. These results were found in both type I and type II diabetics. High dose biotin supplementation may also aid in diabetic neuropathy. When the dosage exceeds biological need, biotin and its metabolites are excreted through the urine. No side effects from biotin supplementation have been reported.
Alcohol inhibits biotin absorption and utilization.
Biotin levels may decrease with the use of antibiotics due to the destruction of biotin-producing gut bacteria. Murray, M. Encyclopedia of Nutritional Supplements. Prima Publishing, 1996. Recommended Dietary Allowances 10 th ed. National Academy Press, 1989.