Then you have to test each signal path. This is if you are lucky enough not to have to buy a lot of new longer cables because now much of your gear is farther from the mixer than it used to be. Longer cables also mean more noise in the signal. I like to keep everything in front of me and everything in reach. The problem is there is only so much space in front of me and my arms can only reach so far.
Compromises have to be made.
Make them carefully. Good studio furniture can help a lot if you choose it carefully. I have a large music work station with my computer keyboard on a sliding drawer which leaves my desk top free for all my papers and notes. My video monitor is on a raised shelf straight in front of me. I hate neck and back pain from turning sideways or looking up or down.