Pure n-hexane is used in laboratories. Inhalation of n-hexane vapors or aerosols is the main route of occupational exposure.
Dermal absorption is usually minor.
Symptoms of peripheral neuropathy develop after a few months to a year of repeated overexposure to n-hexane. The first symptoms are sensory and consist of tingling, numbness, burning, or prickling sensations in the feet or toes. The symptoms are usually symmetric and graded distally, although symptoms may appear in one foot first or may be more pronounced in one foot. If overexposure to n-hexane continues, the dysesthesias spread in a centripetal, symmetrical manner. Ankle jerks are lost and weakness of dorsiflexion of the toes develops.