Cytokines are a large and diverse group of molecules which mediate interactions between cells.
The present invention provides compositions and methods related to regulation of cytokine signaling through the TNF- a pathway. Specifically, the invention provides a novel gene, polypeptide and related compositions and methods for the regulation of TNF Type-I receptor ectodomain shedding. It is contemplated that the compositions and methods of this invention will find use in therapeutics for the treatment of diseases and disorders of the immune system. No part of this publication may be redistributed in any form without prior permission. Terms and conditions for users .