WHO also recommends an additional test called an oral glucose tolerance test. According to the authors report that the ADA fasting glucose concentration alone do not Identify individuals at increased risk of death associated with hyperglycernia. The WHO oral glucose tolerance test provides additional prognostic Information and enables detection of Individuals with Impaired glucose tolerance, who have the greatest attributed risk of death. A noticeable Increase in clonidine poisonings has been reported by poisoning control centers across the country. Though relatively safe in adults, Clonidine can be toxic to children when administered in doses above those recommended.
Children can experience extreme sedation, respiratory depression and hypotension.
Grapefruit juice inhibits this isoenzyme in the gut and presumably in the liver. It is the action at the level of the gut that seems to increase the blood levels of certain drugs. One of the first agents which demonstrated this effect was methadone where the levels were at least doubled. All these drugs' level have been shown to be elevated when used concurrently with grapefruit juice. This effect has been demonstrated to last from 30 to 90 minutes after ingesting approximately 200ml of grapefruit juice.