An inherited disease that belongs to a group of diseases called mucopolysaccharidoses. Causes, Incidence and Risk Factors Hurler syndrome is inherited as an autosomal recessive trait. Newborn infants with this defect appear normal at birth but, by the end of the first year, signs of impending problems begin to develop. The children slowly develop coarse thick features, prominent dark eyebrows, cloudy corneas, progressive stiffness, and obvious mental retardation . The disease damages many organs including the heart and heart valves.
Death occurs in the early teens, often from the associated heart disease .
There is no specific treatment for Hurler syndrome. Therapy must address specific developing problems. Hurler syndrome is a disease with a poor prognosis. Children with this disease have significant progressive physical and mental deficiencies. Death occurs in late childhood or early adolescence .