JAMA Migraine Information Center - Ketorolac vs Chlorpromazine for Acute Migraine Vol. Many treatments for acute migraine exist.
Chlorpromazine is effective but has serious side effects.
Ketorolac has only rare side effects. We performed a prospective, randomized, double-blind trial comparing the clinical effectiveness of 60 mg of intramuscular ketorolac tromethamine with 25 mg of intravenous chlorpromazine hydrochloride in patients with acute migraine headache seen in the emergency department. Pain intensity, quantitated using the Wong-Baker Faces Rating Scale, was measured every 30 minutes for 2 hours in the emergency dtment. Fifteen patients were entered into each treatment arm. No differences were seen between the mean pain scores or the mean change in pain scores.