Severe heart, kidney and nervous system defects These defects have long-term consequences, causing lifelong disabilities . Many victims are dependent on home help or 24-hour care. Ear defects force the usage of sign language as a communication tool however, shortened limbs can make this task more difficult to accomplish. Today, most doctors agree that thalidomide birth defects cannot be passed from one generation to another, and that any limb malformations in second generation babies are most likely a result of genetically inherited conditions, and not related to thalidomide. In addition to birth-related defects, other unpleasant side effects can occur from thalidomide use, ranging from extremely serious to mild.
All users are at risk regardless of age or sex.
Some effects may be long-term, while others may subside once use of the drug is discontinued. Additionally, these symptoms could be caused by another possible side effect called orthostatic hypotension. Users of thalidomide are advised to sit up or stand slowly. Symptoms of toxicity include skin rash, fast or slow heart rate, weakness, fatigue, mood changes, irregular menstrual periods, sore throat or fever. Muscle cramps and loss of coordination may also indicate this condition.