Severe changes in humidity or temperature can bother some people. Excessive cold or very hot weather may cause difficulty. Inquire if air conditioning is available for very warm climates. Some people with chronic obstructive lung disease have allergies. These are generally to molds, dust, pollens, animal dander and some foods.
Avoidance is the most effective method of dealing with allergies.
This however, may be more difficult when you are away from home. If your hotel room has dust or mold, ask to be moved. Bring your own pillow or ask for a non-feather pillow and comforter. Avoid tours that may expose you to environmental factors that bother you. If you have any food allergies, always ask if you are unsure of the food or the methods used to cook the food.