The clinical presentation is usually acute with marked systemic toxicity. It is important to note that the skin overlying the affected area can initially appear normal. However, gentle palpation often reveals severe tenderness and crepitus. The diagnosis is usually suspected on clinical grounds. Radiologic studies demonstrate involvement of deeper structures or gas in tissues.
Bacteremia occurs in a significant proportion of cases.
Prompt surgical consultation for d bridement is indicated in addition to broad-spectrum antibiotics pending culture results. Endophthalmitis is an infection of the vitreal contents of the eye. Exogenous endophthalmitis is usually a complication of cataract surgery. It is caused predominantly by gram-positive organisms, including Staphylococcus aureus and Staphylococcus epidermidis , although other organisms may be encountered. A renal source is sometimes implicated, often with E. coli isolated from cultures.