Long-term use of antacids also increases the risk for kidney stones. These antacids are actually sources of calcium. This can lead to kidney failure and is very dangerous. None of the other antacids have this side effect. It is generally believed that liquid antacids work faster and are more potent than tablets, although evidence suggests that they all work equally well.
Antacids can interact with a number of drugs in the intestines by reducing their absorption.
Interactions can be avoided by taking the drugs one hour before or three hours after taking the antacid. Foaming Agents Foaming agents are available over the counter and work by forming a barrier that floats over the contents of the stomach, thereby preventing reflux. Such medications may be useful for patients who have GERD but no signs of injury to the esophagus. Blockers H 2 blockers block or antagonize the actions of histamine, a chemical found in the body that encourages acid secretion in the stomach. All have few side effects and good safety profiles.