This is an example of 4p- in which a small part of the short arm of chromosome 4 has been lost. This is an example of a deletion. Wolf's syndrome is very rare.
Affected children are small, with microcephaly and abnormal facies.
There are cardiac, renal, and genital abnormalities. Most are stillborn or die in infancy. Affected infants have a low birth weight and a distinctive mewing, cat-like cry. Children have facial anomalies and are mentally retarded.