Pharmacokinetics Lorazepam is moderately rapidly absorbed from the proximal small intestine. It is extensively distributed in the body. It is transformed to clinically acive metabolites. It is metabolised in the liver.
Clearance is reduced in liver damage.
Indications Lorazepam is used as a first line drug in status epilepticus. It is also used in anxiety states and in psychosomatic disorders. Contra Indications Lorazepam is contraindicated in patients hypersensitive to benzodiazepines and in neonates. Interactions Lorazepam potentiates the effects of other CNS depressants. All rights reserved.