No loss of blood or other body fluid. Less trauma for the subject. More frequent sampling. Deliver drug to site while simultaneously sampling. Microdialysis vs. Tissue Culture or Biopsy More representative of normal physiology.
All metabolic pathways are intact.
Subject does not have to be sacrificed. Each subject serves as its own control. No electrode contamination. Microdialysis vs. Imaging No imaging agents or radiochemicals. Identity of target chemical confirmed by analysis.