We are left with trying to evaluate the relative importance of post-transcriptional modification vs. transcriptional regulation. Perhaps the former response provides a first line of protection against apoptosis, while the transcriptional regulation makes this protection permanent. Transcriptional regulation might also ensure, in instances where the surviving cell generates progeny, that the decisions made in the parent cell are passed on as permanent regulatory changes in the progeny. Structural Domains Hid is a novel protein. There are five potential MAP kinase consensus phosphorylation sites.
Apoptosis is an essential process in the development and homeostasis of all metazoans.
In conjunction with other observations, these results reveal how Smac may relieve IAP inhibition of caspase-9 activity.