SAMe is a substance which is naturally made in the body. No serious side effects have ever been reported with SAMe, even in high doses administered intravenously. A recent review in Archives of Internal Medicine dealt with 24,968 people in 34 studies who participated in trials of cholesterol lowering regimens to prevent coronary artery disease. It appears that cholesterol may have less to do with heart disease than the public has been led to believe. The recent data on homocysteine and heart disease suggests that levels of SAMe and its opposite, homocysteine, have more to do with heart disease than cholesterol.
Beta blockers are a class of drugs used to treat heart problems.
People who take beta blockers to block beta receptors in their heart, block receptors in their brains as well. Blocking neal receptors interferes with the synthesis of melatonin . The extent of the disruption caused by beta blockers to circadian rhythms, and the important hormones that depend on these rhythms was illustrated by an animal study showing that ingesting a beta blocker before bedtime is like leaving the lights on all night. What occurs when beta blockers are taken before bedtime looks a lot like sleep deprivation. It also occurs in young people.