Physiologic and morphologic changes in acromegaly. Adapted with permission from Harris. The cardiovascular system is particularly affected in acromegaly. 10 Acromegalics are three times more likely to die from cardiovascular disease than the general population. 3 Figure 4.
Acromegalic cardiomyopathy develops during the disease from the early to the advanced stage.
The different abnormalities may be recognized using appropriate cardiological investigations. Adapted from Lombardi et al. The major causes of death in acromegaly are cardiovascular events, respiratory failure, and malignancy. A retrospective analysis of 151 acromegalic patients revealed a 10-year reduction in survival rates compared with nonacromegalic patients. Am J Med.