Trivalent methylated arsenicals are natural products of the metabolism of iAs in humans, suggesting that methylation of iAs is not necessarily a detoxification mechanism. In fact, these species may significantly contribute to the adverse effects associated with the exposure to iAs. Because of their pronounced biological effects, MAs III and DMAs III may become sensitive biomarkers of arsenic toxicity in humans. Metabolism and toxicity of arsenicals in cultured cells. Comparative toxicity of trivalent and pentavalent inorganic and methylated arsenicals in human cells.
Arsenicals inhibit thioredoxin reductase in cultured rat hepatocytes.
Vega L, Styblo M, Patterson R, Cullen W, Wang C, Germolec D. Differential effects of trivalent and pentavalent arsenicals on cell proliferation and cytokine secretion in normal human epidermal keratinocytes. Selenium modifies the metabolism and toxicity of arsenic in primary rat hepatocytes. Continue to prepare publications for peer reviewed journals and prepare and submit the final report for the grant.