This topic, which might appear to be a simple one to pursue, is not so straightforward. Good markers of biologic age in rhesus monkeys have not been established. In addition, most of what is known about the biologic effects of dietary restriction in rodents is the result of cross-sectional studies of tissues from killed animals, while studies of dietary restriction in monkeys have been minimally invasive. Despite these chronic challenges, we hope that our study is providing a better understanding of the biology of aging in primates and that it contributes significantly to the body of knowledge which can be used by the scientific and medical communities to attenuate the development of the undesirable biological expressions of aging. These centers serve as regional and national resources for solving human health problems through research on nonhuman primate models.
Caloric restriction reduces fiber loss and mitochondrial abnormalities in aged rat muscle.
Hydroperoxide metabolism in mammalian organs. Multiple mitochondrial DNA deletions associated with age in skeletal muscle of rhesus monkeys. Age-s associated alterations of the mitochondrial genome. An integrated theory of aging as the result of mitochondrial-DNA mutation in differentiated cells. Reduced immune responses in rhesus monkeys subjected to dietary restriction.