It is absorbed from the proximal small intestine. It is extensively distributed in the body. Plasma half life averages 24 hours. It is metabolised in the liver.
Clearance is reduced in liver damage.
It is excreted in urine. Indications Clonazepam belongs to benzodiazepine group of drugs. It is used for clonic seizures, atonic seizures, temporal epilepsy, status epilepticus, infantile spasms and absence seizures. In Infants and children up to 10 years of age, the dose is based on body weight. Contra Indications Contraindications are hypersensitivity to benzodiazepines,respiratory depression, acute pulmonary insufficiency,lactation and pregnancy.