Human blood serum was kept at -20 C until the analysis. The zero time blank was run. Because the origin of serum adenosine deaminase is lymphatic, and the immunity in tuberculosis is cellular, the increase in lymphocyte adenosine deaminase activity and turnover of lymphocyte in active tuberculosis were found to be high. The same explanation can be true for leprosy patients. For macrophage formation and chemotaxis, this process needs adenosine deaminase.
Active macrophages have two times higher adenosine deaminase activity than normal macrophages.
The high serum adenosine deaminase activity found in leprosy, as compared to active tuberculosis, can be explained by this mechanism. In summary, the difference in serum adenosine deaminase activity in tuberculosis and leprosy caused by the same group of bacilli can show parallelism, and can also be explained by the same mechanism. Prognostic value of adenosine deaminase compared to other markers for progression to acquired immunodeficiency syndrome among intravenous drug users. Donma MM, Donma O. Diagnostic efficacy of adenosine deaminase for future therapeutic approaches in immunodeficiency disorders. Giusti G. adenosine deaminase.