Natural products from diverse sources are assayed against cloned serotonin receptors available from cell culture in the laboratory. Information from receptor binding determinations is used to prioritize lead extracts which are then fractionated to identify and characterize active principles. Cell Biol . Weber, J.T., O Connor, M.-F., Hayataka, K., Colson, N., Medora, R., Russo, E.B., and Parker, K.K. Activity of parthenolide at 5HT2a receptors. Weber, J.T., Hayataka, K., O Connor, M.-F., and Parker, K.K. Rabbit cerebral cortex 5HT1a receptors.
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Parker, K.K., Norenberg, M.D., and Vernadakis, A. Transdifferentiation of C-6 glial cells in culture.