Since most of the offensive material on the grille comes from the human body, plain water should be a sufficient cleanser. To remove lipstick and other material stuck in the grille, use a toothbrush with soft bristles. In some models, the foam windscreen can be removed from the grille, but this is usually not necessary since water will not damage the grille. Most Shure microphone grilles have a nickel finish that makes them resistant to rust, and replacing the foam windscreen can also be difficult and time-consuming. Microphones don't like water, and although dynamic mics can withstand small amounts of moisture, a soggy foam windscreen will introduce more than is acceptable.
Air drying is the best way to dry the grille, but a hair drier on a low-heat setting can be used.
Care must be taken not to get too close to the grille as excessive heat can melt some windscreen material. Cleaning must be done more carefully for microphones that do not have removable grilles, e.g., SM57, 545. Using a damp toothbrush, hold the microphone upside down and very gently scrub the grille. Holding the mic upside down will prevent excess moisture from leaking into the microphone cartridge. This technique is also useful for cleaning the foam that covers the diaphragm inside an SM58.