Amgen and Regeneron are now testing the drug by putting it directly into the cerebrospinal fluid. The intrathecal pump is made by Medtronic. Amgen and Regeneron also plan to test subcutaneous delivery in an undefined subgroup of ALS patients whom they believe may benefit from this delivery method. Amgen Neurotrophic Factor Shown to preserve motor neurons in laboratory situations where they would otherwise die. Being tested in ALS patients.
Delivery is directly into brain.
Results expected by end of this year. Trial enrollment now closed. Amgen is also testing GDNF in Parkinson's disease. This factor shown to preserve motor neurons in laboratory situations where they would otherwise die. Administered by subcutaneous injection.