When supplemental vitamin B12 was given, partial reversal of the anemia and improvement in mental function were observed. 27 Melatonin Evening administration of valproic acid has been shown to decrease blood levels of melatonin, unlike placebo. Whether valproic acid may cause problems due to melatonin suppression when used as an anticonvulsant drug is presently unknown. 29 One study of 450 people living in Florida, who took anticonvulsants, found minimal evidence of anticonvulsant-induced bone disease, suggesting that regular exposure to sunlight may be protective. 30 Vitamin K Anticonvulsant drug therapy in pregnant women has been associated with vitamin K deficiency in the babies at birth.
Biotin catabolism is accelerated in adults receiving long-term therapy with anticonvulsants.
Disturbances in biotin metabolism in children undergoing long-term anticonvulsant therapy. Reduction of serum carnitine concentrations during anticonvulsant therapy with phenobarbitol, valproic acid, phenytoin and carbamazepine in children. Chung S, Cho J, Hyun T, et al. Alterations in the carnitine metabolism in epileptic children treated with valproic acid. Carnitine deficiency during valproic acid treatment.