This plasma component can be used for coagulation factor replacement therapy, but since the component lacks the labile coagulation Factors V and VIII, FFP is the product of choice for coagulation replacement therapy if available. Contraindications of plasma component transfusion Availability of factor concentrates FFP and Liquid Plasma are not indicated when specific products such as Cryoprecipitated AHF, Factor VIII concentrate or Factor IX concentrate are available to treat isolated coagulopathies. Volume expansion FFP and Liquid Plasma should not be used for volume expansion. Nutritional supplement FFP and Liquid Plasma are not an effective source of protein for nutritionally deficient patients. Other nutritional supplement solutions are available.
Allergic reactions occur with plasma component transfusions.
Urticaria may complicate blood component transfusion if a patient is allergic to some soluble substance in the donor plasma or residual plasma in cellular blood components. Urticaria can be treated by temporarily interrupting the transfusion for administration of antihistamine orally or parenterally. If symptoms are relieved, the transfusion can continue. Although rare, an another type of allergic reaction associated with transfusion of blood components is an anaphylactic reaction. Anaphylactic reactions may begin during transfusion or may develop after the transfusion is complete.