Anterior clones reorganize normal limb pattern, creating supernumerary 'double-anterior' limbs.
Slimb, like PKA, is a negative regulator that normally prevents activity of the Hh signal transduction pathway in the absence of ligand. Both phenotypes are strictly autonomous to the mutant cells, as is the case when the Wg signal transduction pathway is constitutively activated, but not when Wg is ectopically expressed. This pathway cannot be either the Wg or Dpp signaling pathway since inactivation of Wg or Dpp signaling is known to affect either dpp or wg expression, but not both. The phenotypic differences probably reflect the fact that a null allele was used in the current study instead of hypermorphic alleles. Two sequences in the N-terminal domain of Armadillo are involved in its degradation.