The greater the radiation dose, the fewer metaphases are required for detection of abnormalities. Fibroblasts are a convenient and successful target for studies to assess external agent damage. DNA changes can be mapped to within 10 Mb. An expected outcome of the Human Genome Project is the identification of chromosomal changes associated with some cancers. A number of speakers discussed the health impact of beryllium exposure, which in susceptible individuals can lead to an autoimmune-like pulmonary disease.
Beryllium is used industrially in the manufacture of light fixtures and certain ceramics.
CBD also causes granulomas in the skin, liver, lymph nodes, and conjunctiva. Steroids are effective if CBD is diagnosed early, but if treatment is delayed, collagen deposits lead to scarring. In the presence of beryllium, lymphocytes from sensitized individuals can transform and incorporate an isotope, allowing the degree of sensitization to be measured. However, some people with clearly abnormal LTT blood results have no lung disease. Because sensitization is thought to precede disease, LTT might assist in accurate and early diagnosis.