Please inquire for other applications or types of antibodies not listed below. In vertebrate muscle, AChEs exist in two broad structural classes, globular and asymmetric. The catalytic subunits of both classes are encoded by a single gene.
AChE is assembled into multimeric catalytic subunits consisting of dimers and tetramers.
The asymmetric form appears to be anchored to basal lamina components through a disulfide bonded collagen like peptide. The AChE globular form subunits can also associate with the cell membrane through either a disulfide-linked small inserted peptide or through a covalently attached glycophospholipid anchor. Currently, there is no direct evidence that these glycophospholipid-anchored forms exist in the chicken. In mammals, the G2 AChE class is found in erythrocytes and is localized in membranes by a glycoinositol phospholipid covalently linked to the C-terminal amino acid of the catalytic subunits. These tetramers consist of two subunits linked by a direct intersubunit disulfide bond while the other two are disulfide linked to the membrane-binding, non catalytic subunit.