The Center for Disease Control has stated that people with chronic fatigue on average have lower levels of adrenal output. Unfortunately, traditional tests cannot be used to diagnose the condition since there is a wide variation in normal levels. Traditional tests cannot detect this until it becomes severe, a condition known as Addison's Disease, but there is a new test which can be used. The most important substance produced by the adrenals is cortisol, similar to cortisone. Adrenal problems often get worse when allergies are resolved.
Allergies stimulate the adrenals to produce more cortisol.
When this stimulus is withdrawn, adrenal production drops. When the adrenal output starts to drop a strange thing happens. The pituitary gland frantically tries to signal the adrenal to boost its output. The result is wild fluctuations with the adrenals overproducing in the morning and underproducing the rest of the day. Both too much cortisol and too little cortisol can produce fatigue and sinus problems.