Aortic insufficiency can result from any condition that weakens the aortic valve.
Rheumatic fever used to be the primary cause of aortic insufficiency. With antibiotic treatment of rheumatic fever, other causes are being seen with increasing frequency. These include congenital conditions, endocarditis , hypertension , Marfan's syndrome , aortic dissection , ankylosing spondylitis , Reiter's syndrome , syphilis , and other disorders. The disorder affects approximately 5 out of 10,000 people. It is most common in men 30 to 60 years old.