Both the quality of the experience and the potency of the compound have been modified in more recent publications by the originators of this compound. A 40 milligram dose, after an induction period of an hour, produced a vague uneasiness that was interpreted originally as a threshold psychedelic effect. At doses in the 60 to 90 milligram range, there were produced feelings of anxiety and paranoid fantasies, and distinct toxic signs such as flushing, palpitations, and occasional nausea, vomiting and diarrhea.
Any psychedelic effects seem to have been blurred by the more obvious toxic actions of the drug.
I have been told that their final conclusion was that the drug appears toxic in the 50 to 60 milligram range. Reduction to the amphetamine had to be conducted at a low temperature and using only an equimolar amount of lithium aluminum hydride, to minimize reductive removal of the bromo group. Both have been reported. The yield from the direct bromination of 3,4-DMA was apparently very bad. I do not think that the compound has ever gone into man.