Yet, Asians who immigrate to the United States and adopt a Western diet lose this protection. Researchers investigated the potential of genistein, a component of soy, to protect against breast cancer and to cause reproductive and developmental toxicity. Genistein exposure resulted in fewer terminal end buds and more lobules type LI in mammary glands. Cell proliferation with genistein was less than that in control animals. Therefore, early programming events are essential for cancer protection benefits.
Clinical outcome is variable in prostate cancer patients with regional lymph node metastasis.
Patients ranged in age from 47 to 79 years. Median follow-up was 6.1 years. Resulting analysis showed a correlation between cancer node volume, the number of positive nodes, the collective length of metastases, and the diameter of the largest cancer node. The data indicates that volume of the cancer nodes was the most significant determinant of nodal progression to distant metastasis in lymph node-positive prostate cancer patients. The authors recommend that the diameter of the largest metastasis be evaluated in patients with metastases, because this is a more powerful predictor of patient outcome than current methods, which recommend mere counting of the number of positive nodes.