Current treatments are of limited effectiveness.
There is currently no means of tailoring treatment to cause. Large numbers of individuals are affected by these diseases. These include small-molecule products, recombinant proteins, and gene and antisense therapies. All four are in large genome-wide linkage scans, and we have found the location of a novel psoriasis gene. We are studying the genetic causes of asthma, chronic obstructive pulmonary disease, myocardial infarction, peripheral vascular disease and stroke.