There is little change in its effects in patients with renal or liver failure. When used for long operations it is very predictable. Supplemental doses should be 5-10mg. Always flush the vein with saline if using the two drugs at induction. Storage should be in a refrigerator at 4 degrees centigrade as the drug deteriorates at room temperature.
Cardiovascular effects are minimal although the potential problems listed under atracurium apply.
Histamine release is not a feature. Placental transfer is minimal. Its action is slightly prolonged in renal impairment. Vecuronium powder does not need to be refrigerated. General considerations in the use of muscle relaxants Muscle relaxants are principally used to provide good muscular relaxation for surgery.