The cheetah is on the endangered species list, due to loss of habitat, poachers, inbreeding, and attacks by lions. Causing their habitat to become smaller and smaller, has allowed them to inbreed way too much. This has weakened their gene pool, making them more susceptible to disease and death.
Animals can adapt in changes in the environment if they have a high gene pool.
You exist at a price if you have low genetic variation. An example would be to repeat your own clone over and over. This causes a weak clone of yourself, and survival is unlikely. Lions are also a threat to the cheetahs survival, for they kill off their young. The cheetah can out run their prey, especially out in the open.