Immunosuppressed animals may develop massive infections with alopecia, lichenification, and accumulation of thick scales and fissuring of the skin. Histologically, the mites can be seen within the parakeratotic stratum corneum. There is epidermal hyperplasia and an overlying thick crust composed of orthokeratotic and parakeratotic debris, serum, and viable and degenerate neutrophils. Dermal vessels are dilated and lined by hypertrophic endothelium. There is often a perivascular infiltrate of lymphocytes and eosinophils.
Chronic lesions have dermal fibrosis and a predominantly mononuclear inflammatory response.
Science, Brookings, SD 57007. The skin and appendages in Pathology of domestic animals. Jubb KVF, Kennedy PC, and Palmer N eds., Academic press, San Diego, pp. Spores of Icthyophonus -like within the skeletal muscle of a red spotted newt. Although no dead newts were found, the population seemed to be declining.