Only the first two are usually seen however this medication should be carefully monitored by the doctor and regular blood pressure and pulse checks should be made. Also if there is a concern EEG recordings can be taken. Imipramine inhibits re-uptake of norepinephrine. There is a very slight concern of heart deaths and Clonidine must be withdrawn gradually. Overdose is very dangerous.
Clonidine blocks norepinephrine auto-receptors.
The patch may be cut to adjust doseage. It can take up to 2 - 4 weeks to see any effect and maximum effect can take several months. This can also be the case in tablet form. Clonidine should only be discontinued under proper guidence for gradual withdrawal to avoid any withdrawal symptoms. If certain medications help only some of the symptoms a combination of medications may be tried, but only in consultation with your physician or medical practitioner .