Discussion References Introduction Multiple myeloma is the most common plasma cell dyscrasia and typically presents with lytic bone lesions or generalized osteopenia.
Bone demineralization is thought to result from cytokines secreted by the neoplastic plasma cells.
Rarely, myeloma may present with osteosclerosis. Sclerotic myeloma is not in itself a distinct subgroup but a spectrum of disease variants. Myelofibrosis is a nonspecific term referring to increased marrow fibrosis due to fibroblastic proliferation. It is a secondary response of the bone marrow to insult, similar to scarring in other tissues. We report a case of IgG myeloma with diffuse osteosclerosis and prominent marrow fibrosis at bone marrow biopsy, adding support to the theory that these are manifestations of the same disease process.