Disease begins with abnormal irritation, which leads to perversion of function and structure. Functional perversions, from the standpoint of the nervous system are two kinds, central and peripheral. Central perversions are those in which the active irritant is located in some part of the nervous system. Peripheral perversions are those in which the irritant is somewhere outside the nervous system. Structural perversions follow functional changes, except in trauma.
All peripheral irritations produce nerve reflexes.
All central irritations produce either sensory or motor disturbances, or both. Irritation produces vaso-motor changes, so we may say that all physical diseased manifestations are the result of circulatory changes. Therefore all diseased parts can be returned to a normal state by establishing perfect circulation. Hence, the fundamental idea of Neuropathic treatment is to normalize the activity of the constrictor mechanism throughout the body.