Some of these mutations cause cancer. When the immune system is out of balance, B-cells can multiply out of control and cause lymphoma. So does long-term HIV infection. NHL is treated with several different combinations of chemotherapy drugs. The combinations are known by the initials of the drugs.
Chemotherapy is very toxic, and suppresses the immune system.
Common side effects include nausea, vomiting, fatigue, diarrhea, swollen and sensitive gums, mouth sores, hair loss, and numbness or tingling in the feet or hands. Chemotherapy can also damage bone marrow. Neutropenia can increase the risk of bacterial infections. This is a treatment for neutropenia. Radiation therapy is often used instead of, or in addition to chemotherapy.