Those at risk are immunosuppressed people such as organ transplant recipients, and people with cancer, AIDS , or leukemia. Prevention of AIDS prevents opportunistic diseases, including aspergillosis, that are associated with a damaged or incompetent immune system. The goal of treatment is to control symptomatic infection. A fungus ball usually does not require treatment unless bleeding into the lung tissue is associated with the infection, then surgical excision is required. Invasive aspergillosis is treated with a 2 to 3 week course of intravenous amphotericin B, an antifungal medication.
Allergic aspergillosis is treated with oral prednisone.
Some people may benefit from allergy desensitization. Antifungal agents do not help people with allergic aspergillosis. Gradual improvement is seen in patients with allergic aspergillosis. Invasive aspergillosis may resist drug treatment and progress to death. Amphotericin B can cause kidney impairment.