Second, if you drink more than three or four drinks a week, the effects of alcohol may prevent the antidepressants from working. Many people who seem not to benefit from antidepressants, do so, if they reduce or eliminate their intake of alcohol. There is much misinformation about drinking while on anti- depressants. Alcohol can prevent antidepressants from being effective. This is not so much because it interferes with the absorption of antidepressants, it is because of the effects of alcohol upon brain chemistry.
Antidepressants can also increase one's susceptibility to the intoxicating effects of alcohol.
If you are determined to drink despite taking antidepressants you should discuss the matter with your psychiatrist. If you get permission you might want to determine the extent to which the medication has made you more sensitive to the alcohol. You might start by seeing what are the effects of half a glass of wine. You might then experiment with a full glass. It is not unusual for people who have recently been withdrawn from alcohol, or other abusable drugs to become depressed.