The well established familial pattern suggests a multifactorial genetic basis to the condition. There are many observed asymmetries in AIS subjects, but the majority of these are as likely effects of the deformity as the cause of it. It is likely that the aetiology involves fundamental principles of neurobiological development.
Current therapy is empirical, involving observation, bracing or major surgery.
Knowledge of the aetiology may open new avenues for prevention, early detection and treatment. This is an opportunity to apply basic biological research to an important clinical problem. The Philip Zorab Symposia have occurred periodically since 1965. Philip Zorab was a chest physician at the Brompton Hospital in London who developed an expertise in the management of severe scoliosis. He was particularly interested in the aetiology of idiopathic scoliosis.