This procedure promises to significantly improve control through induced resistance. Further research is planned with molecular microbial ecologists and plant biotechnologists to determine what causes this effect and how disease control can be made consistent. Development of the inoculation procedure will continue. Evaluate cardiac function and shape in a temporal manner as a function of the ECM changes. As the heart progresses to CHF, it becomes larger and loses elasticity.
Collagens play a fundamental role in cardiac hypertrophy and interact with proteoglycans.
The level increases as the rats go into CHF with obese rats showing the greatest increase. These findings indicate that these changes in ECM proteins may contribute to the increased stiffness and size of the failing heart. The challenge was to understand the factors that contribute to congestive heart fialure. This information will allow for the development of new drugs that have the ability to reverse changes in these factors. A chievements Despite a decrease in mortality from heart disease since the 1960s, heart disease remains the number one killer in the United States.