Untitled Document Differentiation Inducers 1. Respinomycin A, B, C and D, inducers of erythroid differentiation. Epolactaene, an inducer of neuron differentiation.
Advanced nations are are experiencing the aging of society.
Senility including Alzheimer dementia and neuron degenerative diseases will be a serious problem in these countries. Effective drug development for the neuronal diseases is an urgent issue at the present. Recent studies reveal that neurotrophic factors are effective for the protection of neurons from various hazards including active oxygen and ischemia. The administration of the neurotrophic factor is expected to induce the neuronal differentiation in the brain, however the neurotrophic factor can not pass the blood-brain barrier because it is a protein. We have discovered epolactaene as an inducer of neuritogenic compound from fungal metabolites.