Paget s Disease is most commonly diagnosed in the sixth decade, and increases in prevalence as age increases. It is very uncommon in individuals under 40 years of age. In most cases, Paget s is a mild disease that does not cause any problems or complications. In individuals who do experience symptoms from Paget s Disease, the most common complaints relate to bone or joint pain. Other common symptoms include swelling of joints, tenderness or redness over the affected areas, and occasionally individuals will not know of Paget s until experiencing a fracture through a weakened area of bone.
Diagnosis is made by physical examination, x-rays, and laboratory studies.
The physical examination may show abnormalities of the skeletal shape or bone deformities. X-rays commonly show abnormalities of bone turnover, including areas of increased and areas of decreased bone deposition. Laboratory studies will invariably show an increased level of alkaline phosphatase, a byproduct of bone formation. Calcium levels within the body are usually normal. M.D. About Human Guides.