Two smaller studies, with 78 and 91 patients each, have also shown similar results. T2b tumors were included in the study groups are-evaluating the role of adjuvant hormonal therapy in patients with locally advanced disease. Randomized clinical trial evidence comparing radiation therapy to radiation with prolonged androgen suppression has been published. The incidence of pathologic fractures, spinal cord compression, and ureteric obstruction were also lower in the immediate treatment arm. However, because the duration of follow-up in available studies is still relatively short, the value of postoperative irradiation in reducing the incidence of local failure has yet to be determined.
Clinical trials are in progress.
Careful treatment planning is necessary to avoid morbidity. Careful observation without further immediate treatment. This may often be accomplished by radiation therapy, radical surgery, transurethral resection of the prostate, or hormonal manipulation. Interstitial implantation combined with external-beam radiation therapy is being used in selected T3 patients, but little information is available. Clinical trials employing alternative forms of radiation therapy.