Arginine has so far appeared to be free of obvious side effects, although some doctors are concerned that increases in growth hormone triggered by arginine could overwork the pancreas. Individuals with kidney or liver disease should consult their doctor before supplementing with arginine. Large amounts of arginine in animals can both promote 13 and interfere with cancer growth. On the other hand, in people with cancer, arginine has been found to stimulate the immune system . At this time it remains unclear whether arginine is dangerous or helpful for people with cancer .
Arginine works with ornithine in the synthesis of growth hormone.
At the time of writing, there were no well-known drug interactions with arginine. For the convenience of the reader, the information in the table listing the supplements for particular conditions is also categorized. Besset A, Bonardet A, Rondouin G, et al. Increase in sleep related GH and Prl secretion after chronic arginine aspartate administration in man. Morphological changes in adult males from resistance exercise and amino acid supplementation.