In the target organism, trifenmorph increases intracellular chloride levels in neurons, most probably through alteration of the bicarbonate-chloride shift mechanism. By this means the balance between excitatory and inhibitory threshold in neurons is altered and the entire nervous system is disrupted. 2.1.3 Excretion products In dogs, rats and mice it was rapidly metabolized by gastrointestinal enzymes to triphenylcarbinol, and morpholine. Morpholine was rapidly absorbed and excreted in the urine unchanged as a glucuronic acid conjugate. The oral toxic dose is dependent upon the vehicle.
Chlorinated solvents reduce the toxic dose, suggesting a synergistic effect.
Cumulation of compound - Trifenmorph is unlikely to be accumulative since it is readily metabolized and excreted. Long term - No information available. Trifenmorph was not mutagenically active in amicrobial Ames test. No information available. No information available.