Studies on rodents or primates can be strongly suggestive, but are not often accepted as conclusive on their own. Oftentimes, researchers who are trying to expose the truth about hydrogenated fats are harassed. Read an interview with medical researcher Mary Enig , who fought the edible oils industry and won. It takes a lot of money to perform rigorous scientific studies. Over the last 20 years, the share of scientific research funded by governments has declined dramatically.
Corporations now control the research agenda, even at prestigious universities.
If people want studies, they will have to tell their government representatives to fund them. Medical research funded by manufacturers of the product being researched is utterly corrupt. We think so. How much you can lose depends on how big you are. You should be able to accomplish a modest weight loss with no other change in your diet.