Our long-range objective is to engineer rationally designed surfaces that are specific for particular integrin receptors and elicit controlled cellular responses. Our efforts in this area focus on the genetic manipulation of cells to express the osteoblastic phenotype and produce a mineralized matrix. This approach addresses complications currently associated with using marrow cells and osteoblasts, namely the limited supply of committed osteoprogenitor cells and in vitro loss of the osteoblastic phenotype. Boettiger, D. Force required to break a 5 b 1 integrin-fibronectin bonds in intact adherent cells is sensitive to integrin activation state. Catherine Reyes Jeff Capadona Kathryn Collier Sean Stephansson Teaching 1.
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