Physical Effects of Toxic Overload Individual reaction to toxic overload can vary greatly. The most common symptom associated with toxic overload is fatigue. There are two broad phases of hepatic xenobiotic metabolism. These enzymes move electrons in an attempt to reduce the toxicity of the chemical. The Phase I enzyme alcohol dehydrogenase is zinc dependent.
Aldehyde oxidase requires molybdenum.
The system may become overwhelmed by the massive amounts of pollutants that easily find their way into the body through the air we breathe, the food we eat and the water we drink, as well as from medicinal or illicit drugs, alcohol and tobacco. Even normal systemic metabolism produces free radicals and intermediary metabolites that require detoxification. Intestinal permeability is also a factor. The lining of the intestines absorbs nutrients the body needs and, at the same time, acts as a selective barrier to screen out toxic substances. Once the system becomes overloaded, it us unable to handle incoming stimuli.