Fatigue may be the most important aspect of disability in MS and interferes considerably with activities of daily living. The most important approach to the treatment of fatigue is to teach patients to pace themselves properly. They should not take on excessive physical activity without the ability to rest. Another approach is to avoid even small increases in body temperature by avoiding long periods of vigorous exercise and warm surroundings. Repeated cold baths or showers may help.
Air conditioning is important in hot climates.
Several drugs have been reported to help in some, but not all, patients. Antidepressant drugs can be helpful in some cases.