The body's automatic tendency to maintain a constant internal environment is termed negative feedback. The main target organ of ADH is the anterior pituitary. Only certain cells in the body are target cells for the steroid hormone aldosterone. Only target cells are exposed to aldosterone. Only target cells contain receptors for aldosterone.
Aldosterone is unable to enter nontarget cells.
Nontarget cells destroy aldosterone before it can produce its effect. Nontarget cells convert aldosterone to a hormone to which they do respond. Frequently, very few molecules of a hormone are required to effect changes in a target cell. This is because hormones are lipid soluble and readily penetrate the membranes of the target cell. They travel to different areas of the body.