Endocytosis and recycling of the fibronectin receptor in CHO cells. The method for measuring cycling of surface proteins is applied to a selection of integrins in this and the next paper. It is proposed that cycling integrins may be transported to the front of a motile cell, enabling the cell to reuse them for locomotion. Distinct endocytotic pathways in epidermal growth factor-stimulated human carcinoma A431 cells. J. Cell Biol.
Cells can use their transferrin receptors to locomote.
This paper sets out to examine whether all that a cell needs for locomotion is a surface molecule which both circulates and can bind to the substratum. Getting membrane flow and the cytoskeleton to cooperate in moving cells. A review in which the roles microtubules, microfilaments and membrane circulation may have in cell locomotion is presented. II null mutant can still cap Con A receptors. It had been proposed that myosin II is not required for locomotion but is required for capping, thus implying that the two processes are unrelated.