This is not due to obesity, but the skeletal structure is increased in size. Figure 2 Hyperplasia of the thymus in p27 knockout mouse. The ubiquitin-attachment system consists of several components that act in concert. Although the E3 components are thought to be primarily responsible for substrate recognition, they are the least well understood of the enzymes of the ubiquitin-conjugation system. Cells derived from these animals exhibit hyperaccumulation of both cyclin E and p27Kip1, polyploidy, and multiple centrosomes.
Arrowheads shows the centrosomes.
Note that Skp2-deficient fibroblasts contains a number of centrosomes, and enlarged nuclei. No requirements for p56lck in the antigen-stimulated clonal deletion of thymocytes. Restoration of T cell development in RAG-2 deficient mice by functionally rearranged TCR transgenes. Disappearance of the lymphoid system in Bcl-2 homozygous mutant chimeric mice. Negishi, I., et al.