Testosterone analog testosterone oenanthate is the most studied. Recovery, though complete, may take up to six months and there were no reported effects on sexual functions. Interestingly enough, Asian men were more responsive than Caucasian men were to testosterone treatment, which would be valuable in the highly populated part of the world. Another hormonal approach to male contraception would be LHRH analogs. Normal synthesis and secretion of gonadotropins from the pituitary are dependent upon appropriate stimulation by luteinizing hormone release hormone from the hypothalamus.
Analogs abolish gonadotropin release by overriding the normal pattern of control.
Agonists down regulate pituitary LHRH receptors and desensitization of post-receptor events. LHRH antagonists work by competitively blocking receptor activation. However, in experiments, long term immunization against FSH was unable to produce the sustained suppression of sermatogenesis of testosterone analogs. Another methodological approach could be to suppress sperm maturation in the epididymis and the advantage to this method lies in its leaving the hormonal relationships of the testes intact. Also, the reversal of the antifertility action is relatively rapid compared to testosterone analog treatment with a two week recovery.