1 shows an increase of toxicity with increasing number of methyl groups bound to nitrogen when the compounds are administered parenterally. Fig 4 summarizes toxicity data for different species and i.m. administration. The most sensitive to these compounds were dogs. It is clearly demonstrated that all routes of administration are very effective, including percutaneous administration. Dependence of number of methyl groups substituted on nitrogen and toxicities in rats and different routes of administration.
Arrows indicate isomers.
Arrows indicate isomers. Arrows indicate isomers. Arrows indicate isomers. Value of LD50 is a basic toxicological characteristic for a toxic compound. It can be concluded from the results presented that the class of chemicals studied can be considered as extremely toxic, comparable with others known chemical warfare agents.