This scoring system is correlated well with the severity of disease. This is based on four categories of periportal and bridging necrosis, intralobular degeneration and necrosis, portal inflammation and fibrosis, with total score of up to 22. This scoring system is correlated well with the severity of disease. The normal liver architecture is intact. Eight portal tracts are identified, all of which are free of inflammation.
Bile duct are present in normal numbers and are intact.
Throughout the lobule, there is mild spotty acidophilic necrosis of hepatocytes. Marked golden green pigment deposition is seen in centrilobular hepatocytes and macrophages. Diffuse hepatocellular swelling is also appreciated. Overall, the histopathological changes are not specific for a particular etiology, but are suggestive of early recurrent type C viral hepatitis. Azathioprine treatment might also have contributed to the changes, because withdrawal of the agent apparently resulted in improvement of the liver injury test results.