A higher skill requirement usually means that the formula will have greater power. When they have been learnt once, the character will always be able to use it, if he has nano energy left. Some nano crystals are hard to obtain, and might only be obtained by performing a specific quest or buying it at very high cost. A new player will get a few starting nano crystals. The type of formulas they create is based on the profession of the character.
All professions receives at least one starting nano crystal.
A starting character will also be able to buy or find more. Some general formulas are open for all professions, but the most interesting ones are restricted to one profession. Using the nano bots is a skill-based ability. The character has to learn one or more of the nano schools, and then specialize in one or more formulas. The nano bots are always present in a swarm around the Nano Technician.