A couple usually stays together for life. Mating starts with the male taking stand on a suitable breeding ledge, and when spotting the female he flies out, calling until his efforts are being paid. In old couples, the male will dive at the female, and she at him, both of them screaming at each other. The male will feed the female, in a ceremony where he presents the food while bowing slowly before the female. Often he will turn his head upside down and call her.
Copulation is frequent until the eggs are laid.
The nesting place is used for many years, and is frequently old nests of ravens, buzzards and other nestbuilding birds of that size. Frequently the eggs are laid on the bare rock or ground. In the cities roofs of sky-scrabers are commonly used. Peregrines are very aggressive to intruders, and fears no other birds but the gyrfalcon. Even eagles are attacked if they happen to breed in the same area.