T. Eisen , C. Boshoff, M.M. Vaughan, L. Pyle, I.E. Smith, S.R.D. Johnston, C. Bunker, P. Kitchen, A. Rowe, M.E. Gore.
All solid tumours depend on neo-angiogenesis to grow and metastasise.
Thalidomide is anti-angiogenic and can eradicate experimental murine tumours. Results 3 patients had differential response. 8 patients continue on treatment. Quality of life data analysis shows an improvement in appetite and sleeping. No neurotoxicity was detected.