People at increased risk due to industrial exposure include textile workers, painters, hair-dressers, and people who work with in the leather, metal, or rubber industry. Some studies indicate that there may be a link between high doses of the artificial sweetener saccharin and transitional cell bladder cancer. Results of these studies has lead to the removal of saccharin from the market. Women who received radiation therapy for the treatment of cervical cancer have a fourfold increased risk of developing transitional cell bladder cancer. Bladder cancer rarely occurs in people under 40 years of age.
Bladder cancer occurs more frequently in the United States and England.
Also, within the United States, people who live in the northern half of the country have higher rates of bladder cancer than those in the lower states. Heredity is not a factor in development of bladder cancer, although Jewish people have higher rates of bladder cancer than the rest of the population. A tumor extends through the mucosa but does not extend beyond submucosa B tumor invades the muscle C invade through the fat D cancer has spread to regional lymph nodes or to distant sites Bladder cancers spreads by extending into the nearby organs, including the prostate, uterus, vagina , ureters, and rectum. Metastasis occurs through the pelvic lymph nodes, where the tumor next spreads to the liver, lungs and bones. The choice of an appropriate treatment is based on the stage of the tumor , the severity of the symptoms, and the presence of other medical conditions.