Women then crossed over to the other regimen and response rates and patient preferences were noted. Overall, there was no convincing evidence that soy products ameliorated symptoms more than placebo. Side effects were unusual and mostly confined to the higher dose schedules. Blood pressure was not affected by this low dose of clonidine. The negative data obtained in this study for soy products does not negate the possibility that some women might profit from a trial of soy products or other plant estrogen-like products.
Case reports abound on the efficacy of such therapies.
However, we do not know the relative safety of these products and must keep in mind that there is not regulatory system to assure that the products actually contain what is said on the label and nothing more. An agency or other safety committee must be created to assure our patients the efficacy and safety of the ever-growing herbal medicine industry. We now have several reasonable options for these women with therapy induced hot flashes. The authors accepted 20 studies for meta-analysis. There was no convincing evidence that silicone breast implants were associated with any connective tissue disorder.