It is still not commonly found in our health food stores, but will certainly become more popular in the future. The entire modern era of ethnobotany and search for drugs in the world's rainforests began with cinchona, the only source of natural quinine, the original cure of malaria. Quinine was eventually synthesized, but it is still possible to obtain cinchona bark and to use it as an immunostimulant. It can also be used to as a tonic and stimulate the appetite, treat headaches, leg cramps and colds. This native of Central and South America is perhaps the only 'true' diaphoretic currently known.
Diaphoretics stimulate profuse sweating, usually through the action of glycosides.
But in jaborandi, alkaloids have been found that directly and powerfully stimulate the sweat glands and salivary glands. Whereas other diaphoretics require concomitant heat, jaborandi can be consumed cold and still be effective. The drug pilocarpine is derived from this plant, but the action of the whole plant is more effective, and devoid of serious side effects unless consumed in copious amounts. Papaya, or the pawpaw tree, is the source of the powerful proteolytic digestive enzymes papain and chymopapain. Hailing from Brazil, ipecac is principally known as an expectorant, but is also an emetic, and care must be used in its application.