The genome can serve as mRNA and is directly translatd by host ribosomes into polypepticed. Since the RNA is positive sense, the nucleic acid itself is capable of initiating an infection in the appropriate host cells. All members of the Flavivirus genus are transmitted by arthropods, and are capable of reproducing in their vector. See Flavivirus Live Cycle .
Dengue is characterized by the sudden onset of fever, headache, myalgia, rash, nausea and vomiting.
The disease is endemic in most tropical areas of the world, where the vector is a domestic, day-biting mosquito that prefers to feed on humans. The principal vector is Aedes aegypti. The interaction between FcR and IgG that is bound to virions is thought to enhance the local concentration of virus particle and therefore enhance the rate of infection. Diamond, M.S., Edgil, D., Lu, B., and Harris, E. 2000. Infection of Human Cells by Dengue Virus is Modulated by Different Cell Types and Viral Strains.