The locus of the now obsolete group of mercurial diuretics is pointed out. Further, the general pattern of the tissue-specific aquaporin isoform expression is illustrated, among others in the kidney, eye, inner ear and lung. In more detail we present how particular aquaporin isoforms in the kidney are involved in the regulation of urinary osmolality. Genetic defects in aquaporin-2 are known to result in nephrogenic diabetes insipidus. Further, we point out a variety of disease states which may be related to a dysregulation of water homeostasis.
Aquaporin function is now reasonably accessible to biophysical measurements.
This paves the way to develop and assay novel therapeutic agents. In a final section we outline which questions have to be addressed toward this end, which strategies could be followed and which disease states may benefit most obviously from such a therapeutic approach. Pal Pacher, Zoltan Ungvari, Peter P. Nanasi, Susanna Furst and Valeria Kecskemeti. In addition, these compounds induced significantly less anticholinergic, antihistaminergic and cardiotoxic side-effects than TCAs. However, there is an increasing number of case reports on dysrhythmias, like atrial fibrillation or bradycardia and syncope associated with fluoxetine and another SSRI treatment and overdose.