There is some evidence to suggest short-term prolactin increases in some, patients. These are not generally clinically significant. Weight changes are of major concern to many patients taking antipsychotics. The QT interval on ECG may be prolonged. Cautions Sertindole is contraindicated with drugs known to prolong the QT interval like terfenadine, astemizole, thioridazine, quinidine, procainamide, betrylium, sotalol, tricyclic and teteracyclic antidepressants.
Administration is once daily.
Update Presentations on Sertindole from the Lundbeck Schizophrenia Congress, Vittel, France, September 24th-26th 1996. The novel antipsychotics had therefore a goal of a separation between the dose-response curve for antipsychotic and EPS inducing curves. The pathophysiology of EPS include Ach, 5-HT, and D2 receptors. Sertindole spares these striatal dopamine receptors, has a reduced tendency to induce catalepsy in rodents and EPS in primates. However, the separation between antipsychotic and EPS dose response curves is still not as great as that of clozapine, which does not produce EPS at even grossly elevated doses.