Aberrant patterns of recombination have been implicated in non-disjunction, leading to trisomies of certain chromosomes, which emphasizes the need for a thorough understanding of the standard linkage map. Map integration requires the development and application of bioinformatics software tools for extraction and processing of data from online databases, together with the implementation of algorithms for map integration. These maps are useful in the effort to map genes for common diseases by linkage and association. As well as developing and implementing methodology for disease mapping by linkage disequilibrium with SNPs we are continuing to apply parametric and non parametric linkage mapping. This collaboration provides a focus for our development of combination of evidence from diverse data samples as well as establishing asthma gene candidate regions more securely.
Allelic association is a valuable tool for mapping disease genes.
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