The physical problems caused by the accident are probably contributing to his problem but are probably not the cause. He needs to stop smoking. Occasionally, use of a drug like procardia will help peripheral vasodilation sufficiently to stop the problem. I need to know information with regards to blood clots in the legs associated with chemotherapy and also the need to amputate any part of the leg after clots have been operated on. There are two possible types of clots in the legs - arterial and venous.
Arterial clots are usually due to emboli from the heart.
However, some patients experience hypercoagulability with different types of cancers and can form arterial clots in different parts of the body. Few chemotherapy agents would cause this problem, and usually the reverse. Venous clots usually form in the leg and can go to the lung in severe cases. These are due to low flow in the legs or else the hypercoagable state I mentioned with different cancers. Venous clots do not usually require amputation.