There is inadequate evidence for the carcinogenicity of bromoform in humans. There is limited evidence for the carcinogenicity of bromoform in experimental animals. Monographs on the Evaluation of the Carcinogenic Risk of Chemicals to Man. Based on inadequate human carcinogen data and sufficient evidence of carcinogenicity in animals, namely an increased incidence of tumors after oral administration of bromoform in rats and intraperitoneal administration in mice.
Bromoform is genotoxic in several assay systems.
There are also indications of liver injury. Interscience Publishers, 1963. Documentation of the Threshold Limit Values and Biological Exposure Indices. American Conference of Governmental Industrial Hygienists, 1986. Anesthesia including respiratory failure has been reported.