The growth rate is slow to moderately rapid. The colony diameter is 0.5 to 3 cm following incubation for 7 days. The texture is typically creamy and yeast-like. It appears granular to verrucose on the surface. The color of the colony is white to beige.
Conidiophores arise at right angles to the vegetative hyphae.
The conidia are hyaline and unicellular. They are solitary and pyriform to globose in shape. These blastoconidia are globose in appearance. Although the yeast cells are the major fungal structures found in the infected tissues, mycelial forms of Blastomyces dermatitidis are also observed occasionally. GMS stains the cell wall deep black and interior of the yeast cell rose-colored, with a light green background.