Following oral administration, alprazolam is readily absorbed. Peak concentrations in the plasma occur in 1-2 hours following administration. Because of its similarity to other benzodiazepines, it is assumed that alprazolam undergoes transplacental passage and that it is excreted in human milk. Indications and Usage For the management of anxiety disorders or the short-term symptomatic relief of symptoms of excessive anxiety. Anxiety or tension associated with the stress of everyday life usually does not require treatment with an anxiolytic.
Anxiety associated with depression is responsive to alprazolam.
Contraindications Alprazolam Tablets are contraindicated in patients with known sensitivity to this drug or other benzodiazepines. Alprazolam may be used in patients with open angle glaucoma who are receiving appropriate therapy, but is contraindicated in patients with acute narrow angle glaucoma. Alprazolam is also contraindicated in pregnancy, in infants and in patients with myasthenia gravis. Seizures Certain adverse clinical events, some life-threatening, are a direct consequence of physical dependence to alprazolam. Alprazolam is not recommended for use in patients whose primary diagnosis is psychosis or depression.