The syringe was reweighed after dosing and the residue in the syringe was calculated and subtracted from the total dosage. This was done to hold variability in dosage to a minimum. The duration of the test for each replicate in the crossover study was 48 hours. The chemist who performed the HPLC tests and calculations was unaware of the group assignments for the study. Table 1 gives the mean serum concentrations of phenylbutazone at each time period for both the test product and the standard product.
Concentrations are in micrograms per milliliter.
This study was performed prior to the Center for Veterinary Medicine's Bioequivalency Guideline dated April 12, 1990. However, the study design and statistical analysis meet the criteria outlined in the Guideline. No adverse reactions were reported during the study. An open field study to evaluate palatability of phenylbutazone paste was conducted. Dr. Doyne Hamm Rt.