Further back in our pipeline, we are developing a cocaine vaccine, ITAC , which we expect to enter human clinical trials in 2002. I think if we look at alcohol first, there are currently three products in the market. There is Alcoholics Anonymous Big Book, a book that was introduced in 1937 by Alcoholics Anonymous, which is based upon psychotherapy. It does not address the underlying neurotransmitter problems in addiction. The second product for alcohol is Antabuse TM , which makes the addict sick if alcohol is consumed.
Compliance is a fairly obvious problem.
The third product that DrugAbuse Sciences markets, the oral Naltrexone tablet, is effective, but only if the patient takes it every day. As I mentioned earlier, compliance with daily medication regimens is a major problem for t addicts. We believe our Naltrexone Depot formulation could offer make a substantial improvement in treatment. It is estimated that there are 22 million alcoholics and eight million cocaine or heroin addicts in the U.S. and Europe. Two answers to your question.