In the first hour after treatment with the drugs, increased levels of cGMP, PKG, MEKK1, SEK1 and JNK1 were observed. COX-2 Inhibitors and Familial Adenomatous Polyposis Gary Gordon, M.D., Ph.D., GD Searle. Familial Adenomatous Polyposis is a really strange form of cancer in which the intestines become coated with balloon like growths. When they are growing at a rate of a few a year they can be removed surgically, when they appear by the hundred, other forms of treatment are required. This form of cancer is not very common, but it is an easy one to study and, potentially, provides an avenue into more common forms of colorectal cancer.
Cyclooxygenases catalyze the conversion of arachidonic acids to prostaglandins.
Both work equally well, but Naproxen causes ulcers. Ro 31-7453 is an orally active cell cycle inhibitor and apoptosis inducer. The inhibition of the cell cycle by Ro 31-7453 is reversible for some time simply by washing out the drug. The drug works in a wide array of in vivo cancer models, causing regression of the tumor in some. Toxicity is seen in the bone marrow, lymphoid organs, intestines, liver and testes.