This follows exactly the guidelines that caregivers use for treating HIV infection in general. Within these limitations, at least two of these drugs should be chosen from those with known central nervous system penetration if possible. More uncertain are the protease inhibitors among which indinavir may be the only one with fair penetration. This list is based upon surprisingly limited and sketchy information and likely will need to be revised to both delete some of these and add others as penetration of each is defined better.
Accurate diagnosis is therefore critical, and is up to the caregiver managing the patient.
Also, while these direct treatments are the primary approach to ADC, there are other general measures that should be taken to protect patient safety and to maximize both patient comfort and ability to enjoy life, despite neurological disability.