Varies - kidney problems, poor muscle tone, mental retardation, seizures, short stature, bone problems, glaucoma. Depends on presence and severity of symptoms.
Children die at all ages.
Few live beyond their 30s. Occurs in all races and cultures. Estimated 1-10 per million people. Lowe syndrome is caused by a defective gene that results in the deficiency of an enzyme called phosphatidylinositol 4,5-biphosphate 5 phosphatase. This enzyme is essential to normal metabolic processes that take place in a small part of the cell called the Golgi apparatus.