The majority of research institutions have moved towards core sequencing facilities because it is safe, economical, efficient, and environmentally friendly. Base per base, automated sequencing is more cost effective, reliable, and reproducible than manual sequencing.
Data are easier to manipulate in electronic format and it is easier to proof primary data.
Because the equipment setup costs for a facility are relatively high, universities centralize operations and expertise into a core facility. The user proofs the sequence or fragment data using software and computers provided by the facility. For details, see Submissions . For details, see Cost Structure . Typically we are able to obtain 400-650 bp of reliable sequence per template.