Monitor regularly, about once every 4-6 weeks, when anticoagulation level is stable. Skin rash and alopecia are uncommon adverse effects and may be managed by changing oral anticoagulants. Skin necrosis is a rare complication and usually appears within a few days of the start of oral anticoagulation therapy. Drug interactions are the commonest cause of significant change in the INR value. Patients should be advised not to change any medication without a physician's or pharmacist's advice.
Adequate monitoring is the key to a successful and safe warfarin therapy.
Please refer to the T.I.G. brochure on warfarin therapy. Laupacis et al. 352S -363S. Laupacis et al. Arch Intern Med.