There are so many factors and decisions to make regarding your strategies that even a novel sized manual might not even come close to covering it all. Essentially, the key in this game is to be experiment, be creative, and expect to be killed many times. The characters, vehicles, and enemies are all sprites. Environments are impressively massive and diverse, but as two dimensional as before. Nevertheless, the Fallout world is widely detailed sight to behold, but not greatly improved from the last Fallout game a few years ago.
Animations are also the same, but just as fun to watch.
As before, the wasteland is a violent place, and before the game ends you will most likely see every conceivable means in which a body can be abused in gory bloodletting animation. Let your team get trapped in by turrets and you'll melt to the ground. Let a machine gun rip at close distance to the enemy and he'll splatter like a rag-doll all over your finest suit. Come too close to the swipe of a death claw and you'll watch your own heart pump its last few seconds. Basically, all the pretty things in life.