Acetaminophen or ibuprofen can be very helpful. Activity Your child does not need to stay in bed. Bed rest will not shorten the course of the illness or reduce symptoms. Your child can select how much rest he or she needs. Usually children voluntarily slow down until they no longer have a fever.
Children can return to school when the fever is gone and they can swallow normally.
Most children will want to be back to full activity in 2 to 4 weeks. Precautions for an enlarged spleen Your child's spleen may be enlarged while he or she has mononucleosis. A blow to the abdomen could rupture the enlarged spleen and cause bleeding. This is a surgical emergency. Therefore, all children with mononucleosis should avoid contact sports for at least 4 weeks.