The research isolated cells from sheep embryos and grew them in laboratory dishes. The cells form colonies which are repeatedly split to form more cells. Researchers then took unfertilized eggs taken from ewes, and removed the nucleus of the egg, which contains all of the animal's compliment of genes. The eggs receive a replacement nucleus from the engineered embryonic cell, which are then placed into the ewes to grow into embryos and eventually produce a live animal. Dr. Caird Rexroad, Jr. at the Gene Evaluation and Mapping Laboratory at the Department of Agriculture's Agricultural Research Service in Beltsville, Maryland said that this would enable scientists to insert genes more precisely and swap new genes for old or inactive genes in an animal, eventually producing better barnyard stock.
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Dr. James P. Allison, a professor of immunology at UC-Berkeley, said extensive experiments were needed before the technique could be tested on humans. Unanswered questions include whether the antibody could cause side effects like diabetes and arthritis. In the suit, Monsanto alleges that Ciba's and Mycogen's corn seeds have been engineered to express Bt in corn plants using Monsanto's patented sequencing. Ciba and Mycogen both deny infringement. Mycogen noted that Monsanto's patent covers one particular gene sequence, not all Bt products.