Most other weapons are next to useless against it, although you can use a Tommy Gun if you out of Shotgun shells. His jealousy toward the Chosen was never kept secret. Now that you have been cast from Tchernobog's graces, envy has boiled into sheer abiding hatred. He will be anxious to meet you again and express his feelings for you. Stone gargoyles are nigh invulnerable.
Bullets bounce off their brittle hides and flames find little purchase.
You'll have to be resourceful to survive an encounter with one of these monstrosities. Rapid fire weapons work best, with the Tesla Cannon being the absolute best choice. The Tommy Gun will work, but isn't nearly as effective. Also, crouch when you fight them, as they will rarely be able to hit you. Surrounded by her arachnid spawn, she skulks through darkness, feeding on those hapless souls who stumble into her cavernous labyrinth or are brought there by her loyal children.