Weeds are severe competitors for water and nutrients. There are many ways to control weeds including mechanical, herbicides, mowing and combinations of these practices. The method of choice today is probably some type of herbicide. Herbicides can do a good job but they don't work miracles. Except for grasses, it is very hard to clean pre-existing conditions once the crop is up and growing.
Crop selection has a lot to do with drought management capabilities.
Let your water source, quantity and quality dictate what you plant. Fruit and nut crops are perennial crops demanding water for the current crop, as well as crops in future years. Plan orchards where a long term reliable water source is available. Vegetables are annual crops, requiring large amounts of water to establish the crop and carry it to maturity. Crop selection also should be based on the reliability and the volume of water available.