Central crystalline dystrophy of Schnyder. Dense corneal arcus often accompanies this condition. Central crystalline dystrophy of Schnyder can be detected as early as the first year of life. It tends to be slowly progressive over decades until the corneal stroma becomes diffusely opacified.
Corneal epithelium remains smooth and uninvolved.
The condition is caused by the deposition of cholesterol, cholesterol esters and triglycerides in the corneal stroma. Significantly elevated serum cholesterol and triglycerides are relatively common. Penetrating keratoplasty is the treatment of choice, and is generally required after 45 years of age. Elevated serum cholesterol and triglycerides should be managed in conjunction with a medical specialist. Yes, but grafts tend to remain clear for 10-20 years.