Note that if you accidentally specialise in the wrong thing there is a quest in the Temple of Solusek Ro which can wipe you Specialisations so you can start them all over again. Enchanter Enchanters really only have two choices to go for in specialisation. These are Alteration and Conjuration . It includes roots, hastes, slows, DoT's, charms, and most buffs and debuffs. Most enchanters choose this as their field of specialisation.
Conjuration is used for the mesmerisation series of spells.
This is the major use of crowd control in the game. Some Enchanters once they reach Level 50, complete the quest at the Temple of Sol Ro and switch to this specialisation as they find they are casting more mes-based spells than any other type. It is really a question of gameplay. Generally speaking, unless you are very sure, if you are making an Enchanter I recommend you specialise in Alteration . There are two main choices when choosing what to specialise in as a magician.