Our CD4 T-cells are involved in many activities other than just HIV and some variability is to be expected. An intercurrent infection, for instance, might alter your count. Having your blood test run in a different laboratory might also lead to some variability. As for your fatigue, a decline in CD4 counts is generally not associated with tiredness. With your recent increased stress resulting from your relationship problems, situational depression is the most likely cause of your recent fatigue.
Antidepressant medications can also be very effective.
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