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Depressed consciousness can rapidly progress to coma and generalized seizures.
In some instances bleeding from the nose, gums, digestive or urinary tracts may also occur. Rarely, bleeding within the brain occurs. Histologically, there are widespread micro-thrombi and reactive endothelial proliferation. Thrombi consist of masses of platelets and entrapping erythrocytes and fibrin. Thrombocytopenic purpura is considered chronic when it has lasted more than 6 months.