Lesions are considered major or minor on basis of size, depth and duration. 1 cm deep, usually painful, usually persistent, and often recur. Biopsy if malignancy is suspected. Fine needle aspirate permits microbiologic analysis and decompression. Usual presenting complaints are oral pain and bleeding.
Diagnosis requires quantitative culture of small-bowel aspirate or hydrogen breath test.
Treatment directed against microbial pathogen is unsuccessful for cholangitis. HCV RNA levels and ALT levels do not adequately predict prognosis. HCV has disputed effect on HIV progression. RTV and NVP are the most hepatotoxic. The Johns Hopkins University on behalf of its Division of Infectious Diseases and AIDS Service.