Make sure the cable is plugged in. Parallel port not configured correctly or is bad. Verify that the parallel port is working. Try printing or using the port in some other manner. Try using the ISR kit on another machine.
Cable is plugged in upside down.
The arrow should be on the top. This causes problems for the ISR software. ISR cable is bad. Contact Cypress if one of the other 4 is not the problem. If the software finds any locations that contain 1s, then the device is not blank.