Explain acronyms and vocabulary familiar to only your speciality. Plan your main points. An interview is an opportunity to make your case and educate the public. Select a few key points to make and think about how to explain them. Be persuasive, not defensive.
Brevity is important.
Use analogies to help explain your main points. Don't get mired in statistics and numbers. You are a guest and an expert. Anticipate contrary points of view. A journalist's job is to tell balanced, accurate stories.