Our laboratory is interested in the way glia of the central nervous system interact with neurons during brain development in response to brain injury. Techniques heavily used in the laboratory include cell isolation, a variety of primary brain cell culture systems, protein and small molecule purifications, transmission and scanning EM, neurosurgical procedures, immunohistochemistry, PCR, and a battery of assays to monitor cytokines, eicosanoids, neurotoxins, and mitogens.
Activated microglia are the principal source of thromboxane in the central nervous system.
Immune responses and dementia. Reactive microglia and ischemic injury. A strategy to identify immunosuppressive therapies for Alzheimer's Disease. Alzheimer's Disease Assoc. Microglia and the immune pathology of Alzheimer disease.