I was able to drive home that evening, but there seemed to be some slight residual something after waking in the morning. I would certainly repeat without hesitation. It's worth the cost. My getting to sleep was easy that evening, but sleep was not too restful and there was something strange about it. There is a good lesson to be learned in the attempts to predict the potency of 3-TE before it was actually explored.
All pharmacological prediction follows pretty much a single mechanism.
Find things that are close in some way, and arrange them in a manner that allows comparison. The Roman square. This latter square gave a prediction that was very close to the observed potency, but it would be careless, and probably wrong, to assume that the latter relationships had any more significance than the former ones. As one accumulates the potencies of many compounds it is tempting to draw complex relationships such as these, and to be seduced into believing that they must explain things. And, especially, beware the multivariable power of the computer which can explore monstrous numbers of variables at breakneck speeds, and spew forth fantastic correlations with marvelous ease.