Other Management Considerations Patients with symptomatic late syphilis should undergo CSF examination before therapy. Some experts treat all patients who have cardiovascular syphilis with a neurosyphilis regimen. The complete management of patients with cardiovascular or gummatous syphilis is beyond the scope of these guidelines. These patients should be managed in consultation with experts. There is minimal evidence regarding follow-up of patients infected with late syphilis.
Clinical response depends partly on the nature of the lesions.
Management of Sex Partners Refer to General Principles, Management of Sex Partners. Special Considerations Penicillin Allergy - Patients allergic to penicillin should be treated according to treatment regimens recommended for late latent syphilis. This site produced by the Journal of the American Medical Association through educational grants from Ortho-McNeil Pharmaceutical and Advanced Care Products. 1997 American Medical Association. All rights reserved.