In AIDS patients, both primary and secondary lymphomatous heart involvement are increasing in incidence. Clinical symptoms and signs are vague. Since the hematogenous route is the most common pattern of involvement, even extrathoracic lymphomas can present heart dissemination. Thus, it should be suspected in lymphoma patients who present with even mild aspecific heart symptoms. A negative transthoracic echocardiograph does not exclude the presence of myocardial tumor.
Chemotherapy is only occasionally beneficial, and the prognosis remains poor.
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