Esters are metabolized by plasma and liver cholinesterases. Effects of topical Tetracaine last about 45 minutes. Adrenaline is an aromatic amine. Topically applied, Adrenaline is taken up by adrenergic nerve endings and metabolized by enzymes in the liver and other tissues. Cocaine is a benzoic acid ester.
Cocaine is metabolized by plasma and liver cholinesterases.
Effects of topical Cocaine last 30-60 minutes. Known hypersensitivity to any of the medications. Medications in T.A.C. are potent vasoconstrictors. Ischemia could be induced if applied to tissues nourished by end-arteriolar blood supplies such as earlobes, nostrils, the glans of the penis, or digits. Application to mucosal surfaces is contraindicated due to the potential for systemid absorption of tetracaine and cocaine from these highly vascularized areas.