These are available under a number of trade names and are crop-specific. However, Colorado potato beetles are notorious for easily becoming resistant. Recent studies done by Dr. Jeff Tolman from Ontario's Ministry of Agriculture, Food, and Rural Affairs suggested very high levels of resistance to many chemicals currently being used for control. Resistant beetles quickly mate with others to produce an entire generation of resistant beetles. For this reason, pesticides in the same class cannot be used excessively and spraying should only be done when absolutely necessary.
Beetles are easiest to destroy when they are small larvae.
Complete plant coverage is essential. Cultural Control Crop rotation is an effective way to reduce Colorado potato beetle risk if done correctly. According to University of Minnesota's VegEgde, the beetles migrate by walking unless temperatures are above 70 degrees F ahrenheit . Since the pest overwinters in potato fields, new potato fields should be planted as far away as possible for last year's potatoes. This would limit early infestations of beetles, which is when significant yield reductions from feeding injury would occur.