Augmentation of the effect of radiotherapy on human ovarian cancer cells and primary cancer cells from patients via a recombinant adenovirus encoding Bax is feasible. After these treatment methods, complete remission of the brain metastasis has been observed for 57 months with good quality of life. Concomitant treatment with mild hyperthermia, cisplatin and low dose-rate irradiation in human ovarian cancer cells sensitive and resistant to cisplatin When all treatments were given concurrently the response was greater than the calculated response of all three individual treatments, indicating a synergistic interaction and a good combination for potential clinical application. The effect was greater in the cisplatin resistant cell line. In addition, this could be a good approach to deal with cisplatin resistance.
Brain metastases in epithelial ovarian carcinoma.
Patients who underwent radiation therapy with either craniotomy or chemotherapy for their brain metastases fared better than those who received radiation alone. Successful treatment of brain metastases from ovarian cancer using gamma-knife radiosurgery. The multimodal treatment including gamma-knife radiosurgery has produced complete remission of multiple brain metastases for 21 months with good quality of life. Consolidative 32P after second-look laparotomy for ovarian carcinoma. Consolidative 32P appears to reduce the risk of recurrence and improve survival after negative second-look laparotomy.