Most mammalian cells transport glucose through a family of membrane proteins known as glucose tranporters. Individual member of this family have identical predicted secondary structures with 12 membrane spanning domains. Most differences in sequence homology exists within the four hydrophilic domains that may play a role in tissue-specific targeting. These antibodies do not crossreact with each other and can be used to study specific Gluts in mouse, rat, and human tissues. Availability of multiple antibodies to the same protein should help select antibodies with more interspecies crossreactivity, and to achieve better results in a given technique.
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