It is not known whether articaine is excreted in human milk. Because many drugs are excreted in human milk, caution should be exercised when Septocaine TM is administered to a nursing woman. Chemically, articaine contains both an amide linkage and an ester linkage, making it chemically unique in the class of local anesthetics. Since it contains the ester linkage, articaine HCl is rapidly metabolized by plasma carboxyesterase to its primary metabolite, articainic acid, which is an inactive product of this metabolism. The elimination half-life of articaine is about 1.8 hours, and that of articainic acid is about 1.5 hours.
Articainic acid is the primary metabolite in urine.
A minor metabolite, articainic acid glucuronide, is also excreted in the urine. All Rights Reserved 1100 Terex Rd. Inc. Please review our Privacy Policy for any privacy concerns and our Legal Disclaimer for any licensing and policy questions.