IFN g and IL-2 show some efficacy against the protozoan Leishmania . Immunotherapy employing cytokines and vaccines against cancer will be discussed in a later lecture. Licensure of Varicella Virus Vaccine, Live. Holmes, SJ. 1996. Review of recommendations of the Advisory Committee on Immunization Practices, Ce nters for Disease Control and Prevention, on varicella vaccine.
Active infection confers the strongest and longest-lasting immunity.
The most efficacious vaccines are composed of live, attenuated microorganisms. Live viral vaccines induce cellular immunity in addition to antibody production. Live vaccines should not be administered to pregnant women or to immunocompromised individuals. Instead, these individuals should receive vaccines that are composed of killed microorganisms, purified subunits, recombinant proteins, or synthetic peptides . Adjuvants approved in the U.S. for use in humans include the aluminum salts.