N Engl J Med. Olin B, ed. Facts and Comparisons. 1 gram q 24 hours Pharmacokinetic data show that at 24 hours the serum blood level of ceftriaxone still exceeds the MIC90 of susceptible organisms. Patients weighing more than 250 lbs.
Ceftriaxone exhibits time dependent killing.
Thus, the duration of exposure rather than the concentration is the major determinant of the extent of killing. References Roche Laboratories. All rights reserved.