Category Antifungal Pharmacokinetics Griseofulvin is given orally in divided doses to attain maximum level in the blood. It is mainly excreted through faeces. Because of its very low water solublity absorption from G.I.T is irregular.
Absorption is increased by taking it with fat and by microfining the drug particles.
Griseofulvin gets deposited in keratin forming cells of skin, hair and nails. It is specially concentrated and retained in tinea infected cells. Indications Griseofulvin is used to treat tinea infections of the skin, hair, fingernails, and toenails. It is used systemically only against Trichophyton, Epidermophyton and Microsporum. It is ineffective topically.