Proteins are composed of amino acids. The polar amino acids place themselves on the outside of the protein, while the nonpolar ones stay on the inside of the conformation. This is related to hydrophobic versus hydrophilic. The polar proteins are hydrophilic, which means they interact favorably with water. However, the nonpolar proteins are hydrophobic, which means they interact unfavorably with water.
Amino acids are vital in human chemistry.
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