And each relates to customers in very different ways. Traditionally, retail and wholesale have separated themselves geographically, since they really don't get along too well. Once e-commerce emerged however, this natural geographical separation was lost. Pick one model and build your company around it. Retail is built on customer service.
Customers come for quality and service.
Wholesale attracts based on pricing and product volume. Customers pay for access to cheaper goods, knowing that they're likely sacrificing some amount of quality and service. These two models operate differently, but they each have their appeal. This creates improved accountability, while sacrificing the flexibility to add or remove components. So, you're likely going to be tied closely to your manufacturing partners for a much longer term.