We will characterize their expression profiles in human cancer, study their regulation patterns by various growth factors and oncogenes, and determine their role in angiogenesis and tumorigenesis. HIF-1 plays an important role in normal physiological process as well as in pathological conditions. HIF-1 activity is commonly elevated in human cancer. These studies will provide new insights into the mechanisms of angiogenesis and tumorigenesis in general, and may lead to the development of novel therapeutic agents for many human diseases including cancer. A new therapeutic strategy for the heart disease is by the angiogenesis, the endogenous formation of new vessels.
Cardiovascular diseases are the most important disease in the United States.
There are 60 million Americans that have this disease, claiming one million lives per year. Surgical revascularization and angioplasty are used for patients with coronary artery disease. However, they have limited applications for long-term coronary artery disease due to the restenosis. Angiogenesis represents an effective way of bypassing occluded arteries. Our study will elucidate the role of PI 3-kinase in modulating cellular signals that affect angiogenesis, and will be important for developing novel molecular strategies for the treatment of heart disease.