While macrocytosis and megaloblastic anemia have occurred, these conditions usually respond to folic acid therapy. Lymphadenopathy including benign lymph node hyperplasia, pseudolymphoma, lymphoma, and Hodgkin's Disease have been reported. Coarsening of the facial features, enlargement of the lips, gingival hyperplasia, hypertrichosis and Peyronie's Disease. The lethal dose in adults is estimated to be 2 to 5 grams. Symptoms of overdose may include unusual eye movements, unsteadiness, nausea, dizziness, confusion, tremor, slurred speech, drowsiness, and loss of consciousness.
Death is due to respiratory and circulatory depression.
In acute overdosage the possibility of other CNS depressants, including alcohol, should be borne in mind. If you or someone you know may have used more than the recommended dose of this medicine, contact your local poison control center or emergency room immediately. There is no known antidote. Treatment should be symptomatic and supportive. Dosage Do not exceed the recommended dosage or take this medicine for longer than prescribed.