A 18.6 Vaginal preparations. Terconazole is a synthetic triazole fungicide. It is believed to interfere with triglyceride synthesis in the yeast cell wall. Following intravaginal administration, small amounts of terconazole are absorbed.
Absorption appears to be dose-related.
Terconazole is active in vitro against various strains of Candida albicans and topically in vivo. Its inhibitory effects are both medium and strain dependent. At fungistatic concentrations, terconazole inhibits the transformation of yeast cells into their mycelial form and inhibits the uptake of 14 C into yeast cell membrane sterols. Known hypersensitivity to this medicine. Since small quantities of vaginal applications are absorbed it should not be used in pregnancy since the safety in pregnancy has not been established.