My belief at this point is that there is no added benefit in using 10mg. The reason behind this suggestion is somewhat speculative, but let me explain. Selegiline, via its MAO-B inhibition, can give one increased energy and the other effects noted above. However it also has a powerful antioxidant action by greatly increasing the action of SOD, one the body s three major antioxidant systems. The other 2 antioxidant systems are catalase, which selegiline increases slightly, and glutathione peroxidase, which it has no action on.
Antioxidants disarm free radicals in the body.
These radicals if not disarmed cause cellular damage or celular death. The body s antioxidant system becomes less effective as we age. However, the life span studies have all been done on animals. And it should be noted, for example, that while selegiline significantly increased the life span of male beagle dogs, females experienced no such effect. Ironically this has been speculated to be due to the fact that selegiline increases SOD activity in females much more so than males.