Negative strand RNA virus transcription and replication. Membrane interaction of influenza virus M1 protein. Adenovirus fiber protein.
Adenoviruses infect humans and many different animal species.
Human disease caused by adenoviruses is mostly mild in the western world but viral diarrhea in the third world kills many young children. Adenoviruses are also being used as viral vectors for gene tranfer and there is hope that adenovirus may once be used for human gene therapy. In 1999 the Cusack and Ruigrok groups started a collaboration with groups of the Grenoble University which is proposed to develop into a European initiative on structural genomics of adenovirus. Below are the results of a collaboration with Anna Mitraki of the Grenoble Institut de Biologie Structurale on the biochemical characterization of the adenovirus fiber, the cell attachment protein. Adenovirus fibers are trimeric proteins that protrude from the 12 fivefold vertices of the virion.