Additional research has shown that arginine suppresses the growth of some strains of unfavorable bacteria and inhibits bacterial toxin release, a common problem in those suffering from chronic colitis. Other studies, however, contraindicate the use of arginine for some models of colitis. Arginine promotes nitric oxide synthesis, and several studies have found excess nitric oxide production to be detrimental to colitis patients. Most people benefit from the health benefits of arginine-induced nitric oxide synthesis, but some colitis patients may not. Fiber is an important component of the diet.
Dietary fiber contains soluble and insoluble substrates.
Soluble fiber components are fermented by colonic micro flora, with the resultant production of short-chain fatty acids and gas. Soluble fibers include apple pectin, guar gum and psyllium. The clinical importance of dietary fiber and its metabolic products for good gastrointestinal and non-gastrointestinal functions has yet to be fully realized. During the past decade it has become evident that colonic mucosal metabolism is more complex than previously suspected. Luminal short-chain fatty acids are an essential fuel source for colonocytes, particularly in the distal colon.