Delete application, copy installation files to local hard drive, reboot into safe mode and install form local installation files while in safe mode. Format drive, reinstall OS, and reinstall application. Check with manufacturer for support. Application fails to function properly. Either double check the manual or preferably observe it behaving in the manner you expect on another machine.
Application fails to print.
If they can't, then it's probably a system issue. Create a brand new file, from scratch, put something in it, and print. If it prints, then your program and printer basically work and its something about the file you're trying to print. Try printing other files. If they print, then the file that fails is probably corrupt.