Expression of the mutant Trp334 and Asp324 forms of RI in Y1 cells rendered cAMPdPK resistant to activation by cAMP and inhibited the ability of cAMP to stimulate cell rounding, steroid production and growth inhibition. These observations indicate that the cAMP-resistant phenotype of Kin mutants resulted specifically from single mutational events in RI and thus establish the importance of cAMPdPK as an essential regulator of adrenocortical function. The results indicated that the mutation in Y1DR cells is not in the ACTH receptor, but affects a component that is common to the pathways of homologous desensitization induced via ACTH and beta-2 adrenergic receptors and to the pathway of heterologous desensitization induced via dopamine D1 receptor. Makowska AM TI - Adrenocortical carcinoma. A clinical study and treatment results of 52 patients.
Adrenocortical carcinoma is a rare tumor with a poor prognosis.
This work was aimed at analyzing the clinical outlook and treatment results of 52 patients with this disease. In 11 patients, the adrenal tumor was found incidentally by ultrasonographic scan. Hormonal examinations made it possible to define the endocrine activity of the tumors, whereas imaging techniques helped to determine their staging. Forty-eight patients underwent surgery, and 36 of them received mitotane. The patients with severe hypercorticism were pretreated before surgery with aminoglutethimide and mitotane.