As a drawback, it typically requires at least a partial penectomy. From this viewpoint, it would appear that Mohs surgery would be the most efficacious, allowing specimen examination and sparing most of the tissue. One case report noted that intralesional bleomycin in the wound bed of an incompletely resected tumor was effective with no recurrence at 2 years. Resection with CO 2 laser also has been effective, with the advantage of permitting a bloodless field. Cryosurgery has been effective in several case reports, primarily on small lesions, with normal anatomy resulting after the tumor has resolved.
Close monitoring is required since there is no assurance that the entire lesion has been destroyed.
Most complications of GCBL are the result of the growth of the tumor or of the treatment. As the lesion progresses, fistulization, foul odor, and secondary infections are common. Inadequately treated GCBL has a relentless progression and is fatal by direct spread to pelvic organs. By definition, adequately treated GCBL has a low recurrence rate and, therefore, an excellent prognosis. Human papillomavirus-associated tumors of the skin and mucosa.