Control of Vascular Smooth Muscle Hyperplasia in Experimental Hypertension. One of the hallmarks of hypertension is vascular hypertrophy. We are currently examining the possibility that modification of the expression of P34cdc2 kinase can lead to normalization of abnormal growth in these cells. Differential expression and activity of p34cdc2 in cultured aortic adventitial fibroblasts derived from spontaneously hypertensive and Wistar-Kyoto rats. Genetic control of cardiac development.
Cardiac development is a complex process and is controlled by a number of genes.
Using the RNA differential display, we have identified a number of genes that are regulated during neonatal cardiac development. We are currently studying the role of some of these genes in controlling cardiac development. Molecular cloning and developmental expression of rat glycogenin in cardiac tissue.