Doses should be given a minimum of 6 times a day for trauma and surgery.
Burns can require hourly doses.
Serious burns, major trauma, and surgery should be treated with intravenous ascorbate. The effect of ascorbate on anesthetics should be studied. While practicing orthopedic surgery, I had some experience with trauma cases in which I used ascorbic acid post-operatively. There was virtual elimination of confusion in elderly patients following major surgeries such as with hip fractures when ascorbate was given. This confusion is commonly ascribed to fat embolization and the subsequent inflammation provoked in the tissues by the emboli.