The high-dose can also function to eliminate other, less effective resistance genes from the population. Secondary genes or gene combinations may exist that allow borers to survive a low dose of Bt and pass the resistance to their offspring. This low dose could also allow the accumulation of tolerant genes in individuals, creating more resistant corn borers over time. A high dose would eliminate these borers, reducing the frequency of resistance in the next generation. Pioneer hybrids with the Yieldgard gene have been developed to deliver a high dose of Bt protein.
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