Type II Cytotoxic Response Transfusion reaction Antibody in donor blood attaches to RBC, making it a target for the immune system. IgG and IgM cause direct cell damage. As the RBC is destroyed, hemoglobin is filtered through the kidneys. Type III Immune Complex Response Arthus vasculitis Organ damage of SLE Glomerulonephritis Ulcerative colitis Hyperacute graft rejection Chronic graft rejection IgG and IgM bind to antigens in epithelial lining of blood vessels. The complement system is initiated.
Blood vessels become edematous, with hemorrhage and clotting leading to tissue necrosis.
Minutes to hours following transplantation, due to preformed antibodies which react immediately. Graft HLA antigens are seen as foreign, T cells attack. Rheumatoid arthritis Abnormal B cell, T cell, or complement activity as the body initiates an immune response to its own tissue.