Still, cold extremities, dyspnea, cyanosis are also related. Jaundice may occur. Diffuse capillary leakage leads to hemoconcentration, edema, hypoalbuminemia and pleural effusion. Respiratory distress reflects pulmonary edema. Cerebral hemorrhage is rare.
Definitive diagnosis is established by isolating infectious virus from the patient's blood.
Viruses are more easily demonstrated during the fifth day of illness. Specific serotypes can be determined by the indirect fluorescent antibody test with the use of type-specific monoclonal antibodies on the isolated virus. Still, it is very important to insist that water containers, like tires and plastic containers serve as reservoirs to mosquitoes and they should be emptied and corked. Still, it should be stressed that all suspect cases should be related to health authorities. There is no specific therapy to dengue fever and dengue hemorrhagic fever.