Apoptosis is induced by caspase-family cell death proteases.
Release of cyt c is regulated by BCL2 family proteins. Recently, an ER pathway for caspase activation has been suggested to involve caspase-12. The manner in which caspase-12 activation is induced is unclear. Transcriptional regulation of apoptosis genes is prominently involved in the mechanisms by which NF- k B and p53 modulate cell death pathways. If you would like to make any comments about this website then please use the Comments page provided.