Swamp forests of water-tolerant species dominate the surrounding floodplain, which supports an abundance of palmettos and tropical species. White sand bars add to the beauty of the river and provide intimate camping spots. Quiet and observant paddlers may see swamp bears, deer, bobcats, raccoons, armadillos, opossums, and otters. Shy alligators, turtles, and snakes sun themselves before sliding into the dark, reddish waters. Frogs are more frequently heard than seen, singing their love songs in spring.
Bird life is abundant, and vultures, osprey, hawks, and owls are year-round residents.
Cruising above the water channels are kingfishers, as well as Mississippi and swallowtail kites, which are seen in spring. During migratory periods, songbirds flit across the river channel in front of the boat. Unsubstantiated reports of panther sightings are relatively common. Fishermen pursue the river's largemouth bass, crappie, redbreast, and bluegill. Along the bottom of the toe, the South Prong joins the river and it turns toward Folkston.