The polymerases must deal with chromatin structure. All codons specify more than one amino acid. The genetic code is redundant. All amino acids are specified by more than one codon. The genetic code is different in procaryotes and eucaryotes.
All codons specify an amino acid.
RNA splicing takes place in the cytoplasm. None of the above. DNA replication could not be initiated efficiently. The chromosome would not attach to the mitotic spindle. The chromosome would not be replicated completely.