Ganda contains two active ingredients, adrenaline and guanethidine monosulphate. Adrenaline is an adrenergic antagonist and guanethidine is a post-ganglionic adrenergic neurone blocker. Ames tests have shown guanethidine to be non-mutagenic. It is also non-teratogenic. Repeated high intraperitoneal doses in rats have been shown to cause structural changes in sympathetic ganglia which are only partly reversible.
Adrenaline is a naturally occurring molecule whose use in ophthalmology is well established.
Little specific toxicology work has been carried out, however, the breadth of clinical experience confirms its suitability as a topical ophthalmic agent. The product should be transported and stored in the original packaging. Multidose polyethylene bottles fitted with a polyethylene dropper nozzle and a polystyrene or polyethylene pilfer proof cap. The bottle is contained in a nitrogen filled pouch and packed into cartons. Each bottle contains 7.5ml of solution.