Further exploration of the extensive clinical, Holter and exercise test database from this study will yield a great deal of information about the pathophysiology and treatment of these common manifestations. Dr. Stone and co-workers are also exploring the effect of mental stress in patients with stable angina. An additional area of Dr. Stone's interest is the pathogenesis of atherosclerosis itself, and the potential reversal of coronary atherosclerosis using lipid-lowering therapy. With Dr. Frank Sacks, Dr. Stone began a pilot study in 1982 exploring whether patients with coronary artery disease can be treated with lipid-lowering therapy for extended periods, and whether a repeat catheterization can be performed to assess changes in coronary obstructions. The initial and follow-up catheterizations have been completed in the almost 200 recruited patients from Brigham and Women's and Beth Israel Hospitals.
Analyses are ongoing.
Stone PH, Gibson RS, Glasser SP, DeWood MA, Parker JD, Kawanishi DT, Crawford MH, Messineo FC, Shook TL, Raby K, Curtis DG, Hoop RS, Young PM, Braunwald E and the ASIS Study Group. Comparison of propranolol, diltiazem, and nifedipine in the treatment of asymptomatic ischemia in patients with stable angina. Differential effects on asymptomatic ischemia, exercise performance, and anginal symptoms. The relationship of vessel wall shear stress to atherosclerosis progression in human coronary arteries. Stone PH, Gibson MC, Pasternak R, McManus K, Diaz L, Boucher T, Spears R, Sandor T, Rosner B, Sacks FM, for the Harvard Atherosclerosis Reversibility Project Study Group.