Investigational agents within 35 days of study entry. Acute therapy for an infection or other medical illness within 14 days of study entry. Natural or homeopathic remedies within 14 days of study entry. Antidepressant medications, e.g., Prozac. Caffeine use during the first 5 hours of sample collection on pharmacokinetic evaluation days.
Alcohol intake the day prior to and day of pharmacokinetic evaluation.
Any non-protocol specified drug, licensed or investigational. Compazine within 4 days of PK testing. Inability to be adherent with the study medications during the study period. Inability to participate in the pharmacokinetic study periods. Inability to abstain from high-impact or strenuous exercise for study duration.