Japan Wound healing mechanisms are involved in the pathogenesis of various ocular diseases.
Corneal opacity is caused by abnormal corneal wound healing.
In this presentation, the problems to be resolved and the strategy to develop new therapeutic agents are presented in the area of ocular diseases. In the corneal wound healing, the abnormal extracellular matrix is formed. This process is regulated by many growth factors and cytokines. Blocking the functions of TGF-b abrogated the deposition of extracellular matrix. We compared the effects of regenerated epithelium and those of normal epithelium on the stromal fibrosis formation.