It is poorly water soluble and requires bile salts for solubiliization in the gut. Mechanism of Action Griseofulin disrupts mitotic spindle structure to lead to metaphase arrest. It concentrates in newly formed cells of skin, hair, and nails and is carried with them as they continue their life history into keratinized structures. As the skin, hair, or nail is replaced, the fungus is shed. Pharmacokinetics Used orally.
Absorption is best with high fat meals to aid in solubilizing the drug.
Unabsorbed drug is eliminated in the feces. Most absorbed drug is biotransformed. A small amount is shed in dead skin and hair. Adverse Effects Griseofulvin causes hepatomas in mice and thyroid tumors rats, but there is no direct evidence of tumorigenic activity in other species. Nonetheless, casual use should be avoided.