Focal or multifocal deficits may also result from cerebral ischemia. The CSF is commonly abnormal, with a mild pleocytosis and increased protein concentration. An acute ischemic encephalopathy, manifested by confusion, obtundation, quadriparesis, and bilateral pyramidal signs, has been described in patients with antiphospholipid antibodies. The pathogenesis of the thrombotic tendency associated with the presence of these antibodies is unclear. Immunosuppressive therapy is not indicated.
Cerebral thrombosis is managed as it is in other contexts.