On the other hand, if the space is very small, like a box or a room with no windows, this will become very threatening. Think of a prison cell, and a character doomed to spend his days seeing the same four walls for years and years. If a location has a mood, and your character is aware of that mood, then the shape of that place may help to define and and create this mood. Places shaped with right angles and vaulted ceilings may say something in the way of loneliness or latent hostility. All of this depends on how one designs the area.
Architecture is usually key to the shape of a space.
All places, even those created naturally, have a purpose in a narrative. Natural locations sites are very subtle in their purpose, as the force that created them is most likely nature herself. Perhaps in a moment solitude, the character finds a moment of solace and joy, or perhaps this area is cruel, pointing out the frailty of human nature. Still, one sees that how the area was created impacts heavily on those in it. For human constructed locations, this becomes even more important.