In addition to its action as a weak mitogen it is also a chemoattractant for monocytes and endothelial cells. Both mitogens are secretable proteins, but PlGF-2 can bind to heparin with high affinity. PlGF is apparently a homodimer, but preparations of PlGF show some heterogeneity on SDS gels depending of the varying degrees of glycosylation.
All dimeric forms posses similar biologcal activities.
If PlGF is angiogenic in vivo is not clear. This solution can be diluted into other buffered solutions or stored frozen for future use. Human PIGF-2 is offered for research use. Not for drug use. Not for human use.