Hypersegmentation may accompany other disorders in which there is a disturbance of maturation, such as iron defiency. Although people with concommittant MPO deficiency and diabetes mellitus may develop Candidiasis, MPO deficiency in most people is of no clinical consequence. Acquired MPO deficiency may be seen in acute myeloid leukemia, myelodysplastic syndromes, and lead poisoning. In the homozygote state the nucleus is round. The trait is benign and occurs in 1 in 6,000 people.
Cell function is normal.
Toxic granulation is found in severe inflammatory states. The toxic granules are azurophilic, usually found in the promyelocyte, metamyelocyte, band, and segmented stages. The toxic granulation is thought to be due to impaired cytoplasmic maturation,in the effort to rapidly generate large numbers of granulocytes. L Dohle bodies are single or multiple blue cytoplasmic inclusions. They represent remnants of rough endoplasmic reticulum from earlier maturational stages.