Crewet et al. Bodell et al. Snyder et al. DNA adducts present in peripheral blood could come from DNA adducts formed in bone marrow or formed during the period of transport of benzene metabolites, which could react with DNA of white blood cells from liver to bone marrow. Although levels of adduct in blood are lower, blood is easy to sample.
Blood sampling is of significance in predicting the risk from benzene carcinogenesis to human.
DNA adducts rose the first day after exposure ended and stayed at this level about 4 days. Benzene is absorbed and metabolized quickly after ip injection. A trend of declining RAL is shown after the first 4 days. The persistence of DNA adducts illustrates not only the carcinogenesis of benzene and its metabolites but it also provides a scientific basis for sampling time of biomonitoring to humans. Benzene Monographs on the Evaluation of Carcinogenic Risk of Chemicals to Humans.