In Europe, SAM-e is sold by prescription, which makes sense to me. Not an herb, vitamin, or mineral, SAM-e is a chemical that's produced in the human body. It's involved in several different reactions and processes that occur naturally each day. In my mind, SAM-e is a drug with risks and benefits that haven't been adequately studied. We do know that once inside the body, SAM-e turns into homocysteine, and a high level of homocysteine may be linked to heart disease.
Depression is a treatable disease.
I respect your desire to go natural, but if I were you, I'd discuss the herb St. John's wort with my doctor before considering SAM-e. For centuries, people have used St. John's wort to treat anxiety, insomnia, and depression. Although herbs aren't regulated by the FDA either, many more studies have been done on St. John's wort. Taken under your doctor's supervision, it can be a safe and effective natural alternative. Best wishes, Dr. Anne Dr. Anne has a special interest in blending the best of Western medicine and traditional healing.