In pigs, the main sign is lameness. There is also fever and loss of appetite. Vesicles form along the top of the foot, on the heels and between the claws. The feet are sore and affected, pigs prefer not to move. Vesicles may also be form on the snout, but tend to rupture quickly.
Abortion is common.
Mortality in piglets can be high. In sheep and goats, the disease is usually milder with fewer lesions. Affected sheep are depressed and reluctant to stand. Some animals may get a sudden lameness. Vesicles form around the top of the foot and between the claws.