Vitamin B12 is found mostly in meat and animal proteins. B12 is stored in the liver. A deficiency can lead to symptoms such as dementia, changing moods, irritability, paranoia, mania, and confusion. Folic Acid Low levels of folic acid have been noted in depressed patients. In elderly patients, this percentage may even be higher.
Depression is the most common symptom of a folic acid deficiency.
Without the methyl group, the neurotransmitter cannot perform its function. SAM is the major methyl donor in the body. The antidepressant effects of folic acid appear to be a result of raising brain SAM content. Supplementing the diet with folic acid, vitamin C, and vitamin B12 was found to increase BH4 levels in the body. Patients with recurrent depression have been shown to have reduced BH4 synthesis.