I think I'm developing a couple of saddle sores. I can It recurs intermittently here. Lots of comments about keeping clean to keep the bugs at bay, all to the good. However, there is more to saddle sores than infection. Skin has several defenses against bacterial invasion, all of which must fail before infection occurs.
Abrasion breaks the physical barrier, and preventing it is the reason for good bike shorts.
Lubrication is sometimes helpful too. I recommend not Vaseline but Desitin. Yup, the diaper rash stuff. That is, the skin and subcutaneous fat between your bones and the saddle get compressed. Blood doesn't flow through them much.