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Bone resorption is bone destruction.
Thus, the bisphosphonates are compounds which block bone destruction. But the time was not ripe for industry to jump into this application. As you know it took many years. Unfortunately, the doses which were needed to inhibit pathological calcification inhibited also normal calcification. That was a problem because we didn't want a drug to prevent, for example, coronary artery calcification, but would make our bones brittle because of osteomalacia or rickets.