If you miss a dose Take the dose you missed as soon as possible. However, if it is nearly time for your next dose, take that one and keep to your regular daily schedule. Do not double up doses. Principal side effects that may occur Gastrointestinal Loss of appetite, nausea, vomiting, diarrhea, abdominal cramps. To help reduce these effects, take pyrimethamine with meals.
Anemia can take the form of loss of appetite and unusual fatigue or weakness.
Contact your physician. Skin Rash or other more serious dermatological effect . Contact your physician. Your physician will monitor your complete blood count very closely, and adjust your treatment if necessary. Your physician will monitor your blood count, and adjust your treatment if necessary.