To all researchers, clinicians and Support Staff. An article in the most recent edition of Chemical and Engineering News expresses safety concerns regarding the handling of some chloroforms and the possible spontaneous generation of phosgene gas in storage bottles.
Chloroform is sold containing a preservative.
The bottles had been properly stored in the absence of heat or light. The problem was discovered when an unusual darkening of an aqueus DNA phase was seen during routine chloroform extraction, associated with an unpleasant musty smell. As this may represent a previously unrecognized potential chemical hazard, I would ask that you verify ALL stock bottles of chloroform for their preservative. I am arranging to obtain the required materials to test chloroform bottles, and will ensure that no phosgene gas is present. If you have any questions, or would like further info, please do not hesitate to contact me at extension 8046.