Our research focuses on normal and pathophysiological integrated cardiovascular control with emphasis on interactive effects by interventions and disturbances occuring during anesthesia and intensive care. Our recent studies show that the inotropic and vasoactive responses of exogenous dopamine are not affected by isoflurane. The neurogenic pathway seems particularly powerful for desflurane. The significance of neurogenic reflex cardiovascular control is investigated in models with controlled perfusion pressures to the baroreceptor area.
Data demonstrate a dose-dependent attenuation of baroflex responsiveness by fentanyl.
This response is potentiated by isoflurane, indicating a significant role of angiotensin for maintenance of cardiovascular stability during anesthesia. In our rat endotoxemia model, the integrated cardiovascular reactions include an early hypotensive phase. This response does not appear to be crucial for the development of intestinal morphological pathology. Colloid therapy increased oxygen delivery, while total oxygen uptake was not affected. Kardiovaskul r kontroll under anestesi och intensivv rd.