Keep a guaranteed killer bit for the end of the set. Always end on a laugh. Stay away from anything mean spirited. Prepare some heckler comebacks and tag lines for jokes that fail. Practice, practice, practice and then practice some more.
Clean acts can make very good money working colleges, cruise ships, TV and corporate functions.
The Show Be prepared. Deliver your material effectively and with confidence. Read the audience. Watch how they respond to the MC and other comics. Determine their mood and tastes.