It has to be good. Only high quality printing on good quality paper will do. There must be no spelling mistakes or other 'typos'. The formatting must be consistent throughout. Arial is often used but is rather bland.
Courier looks like old lecture notes.
Use your CV to promote yourself and show others what sort of person you are. Demonstrate enthusiasm for your work and your leisure. Whether to bind your CV or present it in a nice plastic wallet might depend on how many you need to provide. It may leave your hands in perfect order but it may not stay that way at the other end. A clear cover will prevent inadvertent marks tarnishing that essential first impression.