Currently, patients are treated with methotrexate, a steroid to reduce the chance that GVHD will occur. GVHD occurs when the donor marrow recognizes the patient's tissue as foreign. Transplanted white blood cells begin mounting an attack, even though the white blood cells types are the same, resulting in a number of symptoms ranging from mild to severe, and in some cases fatal. GVHD primarily affects the skin, liver and gastrointestinal tract of a patient. The most common symptoms are skin rashes, jaundice, liver disease and diarrhea.
Antibodies are proteins that play a key role in the body's immune system.
When a foreign invader enters the body, antibodies identify this and defend the body against the invader. Researchers have worked to create laboratory-made antibodies that are equipped with the recognition capabilities of natural antibodies. The laboratory-made antibodies are called monoclonal antibodies. CD28 is such an antibody. By clicking the 'Search' button, you agree to the terms and conditions under Disclaimer .