This may look cool, but makes reading a lot harder. And a bit more info about tactics would be nice, although I believe they'll save this for their strategy guide like most companies do nowadays. The game interface hasn't changed much. It's still a taskbar on the right with the options, and the remainder of the screen gives you a view of the battlefield. After reading through the manual I started a campaign as commander of the GDI forces.
Controls work like the previous games.
Right click to deselect. The game screen is again divided in a big 3D view and a small bar on the right with radar map and build options. As soon as it discovers a weak spot it will hit it with all its rage. This means that, unlike some other strategy games, defence is very important. Right after I started setting up my base, the first scouts of the enemy already came checking up on me.