You want clients to use a proxy, but don't want them to know they're being proxied. You want clients to be proxied, but don't want to go to all the work of updating the settings in hundreds or thousands of web browsers. This is where transparent proxying comes in. A web request can be intercepted by the proxy, transparently. That is, as far as the client software knows, it is talking to the origin server itself, when it is really talking to the proxy server.
Cisco routers support transparent proxying.
So do many switches. Linux can act as a router, and can perform transparent proxying by redirecting TCP connections to local ports. However, we also need to make our web proxy aware of the affect of the redirection, so that it can make connections to the proper origin servers. The first is when your web proxy is not transparent proxy aware. You can use a nifty little daemon called transproxy that sits in front of your web proxy and takes care of all the messy details for you.