Fill your gas tank before heading to the refuge. It's best to gas up in Burns, as gas might not always be available in some of the smaller towns near the refuge. Make sure you read the signs at the refuge. The refuge is a heavily signed area, and there are lots of restrictions . So pay heed to where you're going, and tread lightly.
Access is restricted to daylight hours by automatic gates.
One last note. This area is full of marshy areas that are ideal for breeding hordes of hungry mosquitoes. If you go between April and November, take plenty of repellant. The Malheur National Wildlife Refuge encompasses an area that has been valuable to humans for over 10,000 years. Unlike us however, ancient man sought the birds and other animals primarily as a source of food.