Numerous fine tentacles extend from the bell margin. For many years Aequorea was collected commercially to harvest the minute quantities of these proteins for use as markers in biomedical research. Although Aequorea will feed on crustaceans, it tends to favor gelatinous prey, including other hydromedusae, comb jellies and appendicularians. Aequorea are not a commonly found jelly in Monterey Bay, and are more reliably found during spring and summer in coastal waters of Washington and British Columbia. It is relatively easy to establish hydroid colonies and culture Aequorea in captivity.
Crystal jellies are one of the more popular species for display at public aquariums.