A and C systems and reagents affecting cellular phosphorylation and dephosphorylation. Experiments currently under way are aimed at identifying the developmental stages when transcriptional and translational events for embryonic PA production occur. Preliminary experiments with cattle and sheep embryos have suggested that uPA production is cell stage-specific and transcription and translation of the uPA zymogen may occur during the transition from maternal to embryonic genomic control of development. We are also conducting work to elucidate the physiological relevance of this enzyme to processes involved in cellular migration and differentiation during early embryogenesis. Plasminogen activator production and enhanced development in medium containing plasminogen or plasmin by rabbit embryos in vitro.
Bovine embryos produce a urokinase-type plasminogen activator.
Dyk, A.R., and A.R. Menino, Jr. The relationship between plasminogen activator production and bovine embryo development in vitro.