Your liver is the organ that allows the substance to enter the body. If the liver is capable of doing its job it may allow a small amount to enter the body and may eliminate the rest. If the liver is not capable of this process to much of the substance may enter the body and cause a toxic chemical over load which may result in blood poisoning and further more death. As years of chemicals build up in the liver and blood steam the liver starts to fail. The end result is the body becoming so toxic it starts to slow down until it dies.
Allergic reaction happens shortly after taking a substance.
Generally from the moment ingested up to 60 minutes. Toxic reactions can be similar to allergic reactions but more severe and may take several years to show up. Side-effect can be the worst of all. They can cause extreme pain and suffering and often loss of life. We have for over a decade.