Induction of the growth inhibitor IGF-binding protein 3 by p53. Therapeutic effect of a retroviral wild-type p53 expression vector in an orthotopic lung cancer model. Systemic gene therapy with p53 reduces growth of a malignant human breast cancer in nude mice. From serendipity to targeting. Site-specific gene expression in vivo by direct gene transfer into the arterial wall.
Cationic liposomes target angiogenic endothelial cells in tumors and chronic inflammation in mice.
Nitric oxide induces apoptosis in mouse thymocytes. I inhibits human breast cancer in vivo . Peptides derived form two separate domains of the matrix protein thrombospondin 1 have anti-angiogenic activity. A novel angiogenesis inhibitor that mediates the suppression of metastases by a lewis lung carcinoma. I complementary DNA into a human breast carcinoma cell line reduces primary tumor growth, metastatic potential, and angiogenesis.