Histological sections of 66 vulvar biopsies. Six consultant pathologists working at different European institutions independently reviewed 66 vulvar biopsies. The frequency and the degree of disagreement were calculated by a symmetrical agreement matrix showing the number paired classifications.
Current terminology offers a reproducible tool in the hands of expert pathologists.
The objective of this study was to review clinical characteristics, histological findings, and surgical treatment of patients with granular cell tumors of the vulva at Hartford Hospital and examine histologic characteristics associated with those cases that recurred. A retrospective case review of 13 patients diagnosed with granular cell tumors of the vulva at Hartford Hospital from April 1982 through May 1998 was undertaken to compare age, size and location of the lesion, histopathologic features, presenting symptoms, progression of disease, and treatment. The advancing edge of the tumor was noted to be irregular and infiltrative in 8 of the 13 cases. The tumor edge in the remaining 5 was pushing and well demarcated. Five of the eight tumors with an infiltrative edge recurred despite the fact that 3 of the 5 cases had negative surgical margins at resection.