There is inadequate evidence in humans for the carcinogenicity of acrylamide. There is sufficient evidence in experimental animals for the carcinogenicity of acrylamide. Acrylamide and its metabolite glycidamide form covalent adducts with DNA in mice and rats. Acrylamide and glycidamide form covalent adducts with haemoglobin in exposed humans and rats. Acrylamide induces gene mutations and chromosomal aberrations in germ cells of mice and chromosomal aberrations in germ cells of rats and forms covalent adducts with protamines in germ cells of mice in vivo .
Acrylamide induces chromosomal aberrations in somatic cells of rodents in vivo .
Acrylamide induces gene mutations and chromosomal aberrations in cultured cells in vitro . Acrylamide induces cell transformation in mouse cell lines. For definition of the italicized terms, see Preamble Evaluation .