This could be a serious disadvantage if you, like me, prefer plain speaking and direct action. Alternatively, if you're a master of the corporate game, headquarters will be the perfect playground. But it's not just the political climate that is likely to change. You'll be moving to a new part of the country, or even to another country. That can be a big change, which won't affect just you.
Any move is a matter for the whole family.
You won't succeed in the new job unless your family, if you have one, is as happy as you are about moving. You need their support. That's a big disruption. You all need to know you'll be happy in the new area. That means that your employer will have to be very supportive in the relocation process.