Creatine supplementation has been reported to improve strength in rare diseases of muscle and energy metabolism. Creatine monohydrate is well absorbed and tolerated by the stomach. No kidney toxicity has developed at lower doses as recommended. There are no known drug interactions. Kreider RB, Ferreira M, Wilson M, et al. Effects of creatine supplementation on body composition, strength, and sprint performance.
Creatine is an ergogen for anaerobic exercise.
The nutritional biochemistry of creatine. Grindstaff PD, Kreider R, Bishop R, et al. Effects of creatine supplementation on repetitive sprint performance and body composition in competitive swimmers. Greenhaff PL, Bodin K, Soderlund K, et al. Effect of oral creatine supplementation on skeletal muscle phosphocreatine resynthesis.