A serologic-based test determines a person's HLA tissue type by noting which types of sera react to the person's white blood cells and which sera do not react. Molecular Molecular-based tissue typing uses standardized synthetic probes and primers to determine a person's HLA tissue type. These probes and primers do not react to the antigens expressed on a person's white blood cells, but to the DNA that specifies which antigens are present. Because of the standardized probes and primers, molecular typing is more accurate than serologic typing. It also provides more typing information at a higher level of detail because it is able to identify alleles as well as antigens.
Alleles determine which antigens are present on the cells.
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