We are testing the hypothesis that drug resistance mechanisms inherent to normal glial cells, and retained in gliomas, explain the chemosensitivity of oligodendrogliomas and the relative chemoresistance of astrocytomas. DNA repair processes, metallothioneins, transmembrane pump mechanisms and other mechanisms of drug resistance are being evaluated in normal oligodendrocytes and astrocytes. Additionally, we are studying the expression of p53-dependent genes in the developing mouse brain, as well as the effects of p53 gene status on the chemosensitivity of astrocytes. Finally, we are developing a murine glioma model. The absorbance of untreated cells was normalized to a value of 1.0.
Bars depict the standard error of the mean.
An analysis of prognostic factors and timing of radiation. Lack of germline mutations of CDK4,p16 INK4B in families with glioma. Tumors of the nervous system. Lippincott, Philadelphia, pp. Blackwell Scientific, Cambridge, pp.