Classes combine didactic presentations and student-lead discussions of current publications. Grades for this course are based on the quality of the student-lead discussions and on a paper to be handed in two weeks after the last lecture. Hypertension, atherosclerosis, and restenosis are vascular diseases that lead to vascular wall remodeling and blood vessel dysfunction. This course discusses the changes in smooth muscle and endothelial cell function that contribute to the pathogenesis of vascular disease. Each of these topics is discussed in the context of atherosclerosis, restenosis, or hypertension allowing similarities and differences in the cell biology leading to these diseases to be compared.
Classes combine didactic presentations and student-lead discussions of current publications.
Grades for this course are based on the quality of the student-lead discussions and on a paper to be handed in two weeks after the last lecture. This course presents the basic concepts involved in regulation of local blood flow, transcapillary exchange, and interstitial transport. These topics are integrated to emphasize the importance of the cardiovascular system in maintaining the cellular environment. One focus is on the quantification of microvascular permeability to plasma proteins. A second focus is on mechanisms of intrinsic vascular tone and regulation of blood flow.