The wedge biopsy of liver is from the subcapsular region. The normal lobular architecture is largely replaced by an active, predominantly macronodular cirrhosis. The normal spatial relationship between portal tracts and central veins has been completely disrupted in most areas. In addition, several nodules, surrounded on all four sides by fibrosis, are seen. On closer examination, there is a mild to moderate mononuclear inflammatory cell infiltrate within the fibrous septae.
Bile ducts are intact, and no florid duct lesions are seen.
Interface activity is appreciated. Focal oncocytic metaplasia of the hepatocytes and cautery artefact are also seen. No definite ground glass cells are identified, and no prominent increase in pigment is seen. Overall, the changes are indicative of significant chronic inflammatory liver disease, such as chronic Hepatitis B or C virus infection. Clinical correlation is suggested.