Contact guidance plays a role in promoting axon outgrowth in some cases.
Fibers in the ECM that are under tension selectively attract growing neurites Guidance by adhesive gradients Figure 8.6. Small spots of laminin on glial cells along the pathway of some axons may mark the pathway for axons to grow. Multiple binding sites on the laminin molecule allow for interactin with a wide variety of cells. Isoleucine rich segment of the B 2 chain is essential for some neurite outgrowth. A glycoprotein portion of the laminin binds with a glycosyltransferase on growth cones.