Conditioned place preferences were assessed by allowing uninfected animals free access to both compartments for 15 minutes and the time spent in each was measured. Under these conditions, animals receiving saline in both of the compartments would not show a preference for either the black or white sides of the testbox. All agents were dissolved in distilled water. Haloperidol and sulpiride were dissolved in one drop of glacial acetic acid and SCH 23390 in one drop of lactic acid. They were then diluted with water to yield the desired concentration.
All doses refer to the base and the same vehicle as the drug in each case.
Rats and mice received injections of saline during the conditioning sessions, exhibited no significant preference for either compartment of the shuttlebox, confirming that the conditioningprocedure used, was unbiased. As shown in Fig. 30 min before injection of Li, potentiated the aversive effect of Li. Discussion Lithium is an effective agent in the treatment of manic-depressive illness. The biochemical and pharmacological actions of Li have been studied in various tissues and different animal species, including man.