Generally, solid spacer anti-backlash designs keep drag torque at a minimum. Constant motion at load is readily supplied by ball screws. Because they generate low frictional heat, their duty cycle is practically unlimited. Speed of the linear output motion is a function of the lead angle and the screw speed. Lead screws can't rotate all that quickly due to the frictional heat buildup.
Ball screws offer a different slant.
Position accuracy , including resolution and repeatability, is affected by the lead and the backlash. Lead screws with extremely low leads are good candidates for slow, high-resolution travel. Again, ball screws are generally available only in moderate lead ranges. A compliant spacer preloaded nut assembly works to keep backlash down in a ball screw. As for backlash, standard ball and lead screw configurations can have between 0.002 and 0.010 in.