Ongoing efforts are directed to the simultaneous analysis of 4 or 5 distinct targets in single cells. In addition, we are focusing on developing FISH assays for laboratorial diagnosis of leukemias. Studies aiming the development of a distinct strategy to detect translocations involving the E2A gene mapped at 19p13.3 are also ongoing. Since E2A is involved in more than one translocation, our efforts are concentrated in optimizing a probe configuration that identifies breaks within E2A, independently of the partner gene. Publications Barrera JE, Hong Ai, Pan X, Meyers AD and Varella-Garcia M. Malignancy detection by molecular cytogenetics in clinically normal mucosa adjacent to head and neck tumors.
Chromosomal duplication accompanies allelic loss in non-small cell lung carcinoma.
Ai H, Barrera JE, Pan Z, Meyers AD and Varella-Garcia M. Identification of individuals at high risk for head and neck carcinogenesis using chromosome aneuploidy detected by fluorescence in situ hybridization. The University of Colorado Health Sciences Center is committed to equal opportunity and affirmative action.