The long bone shortening might not become sonographic apparent until 24-26 weeks of gestational age 3 08D0C9EA79F9BACE118C8200AA004BA90B02000000080000000E0000005F005200650066003300370039003100390037003000380031000000 . Absence of fetal respiratory movement. The main visceral abnormality is cystic dysplastic renal disease , which is progressive and not usually apparent before birth, althought association with oligohydramnios has been described 3 08D0C9EA79F9BACE118C8200AA004BA90B02000000080000000E0000005F005200650066003300370039003100390037003000380031000000 . If renal dysplasic disease is not found, polyhydramnios can appear. Jeune should be thought of prospectively among the numerous cases of increased nuchal translucency with normal standard karyotype.
Associated anomalies are numerous as described later.
An incidental cord cyst. Patients who survive respiratory failure may have an improvement in the relative growth of the thoracic cage and might have slight to moderate shortness of stature. Progressive hepatic dysfunction appears 16 08D0C9EA79F9BACE118C8200AA004BA90B02000000080000000E0000005F005200650066003300370039003000330031003300330039000000 and may contribute to a poor long-term prognosis. Survival to the fourth decade has occurred 12 08D0C9EA79F9BACE118C8200AA004BA90B02000000080000000E0000005F005200650066003300370039003100310034003400380039000000 . Termination of pregnancy can be offered before viability.