It was issued on October 15, 1794. There is absolutely no documented proof that Betsy Ross designed the American Flag. In 1976 Sarah Caldwell became the first woman to conduct the Metropolitan Opera in New York City. The discovery by Robert Koch in 1876 led Louis Pasteur to developed an attenuated anthrax vaccine, the first such vaccine. This in turn led him to develop the rabies vaccine.
Anthrax is a highly infectious animal disease which can be transmitted to humans on contact.
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