It can not dissolve in the blood. The levels of HDL and LDL in the blood are measured to evaluate the risk for atherosclerosis. High blood pressure means that the heart has to work harder than normal, putting both the heart and arteries under greater strain. When the heart is forced to work harder over time, it tends to enlarge. A slightly enlarged heart can function well, but a significantly enlarged heart has a hard time meeting the demands put on it.
Arteries also suffer as over time they become scarred, hardened, and less elastic.
As the arteries become hardened and narrowed they may be unable to supply enough blood for the body's organs. The heart, brain, and kidneys are especially prone to damage by high blood pressure. Angina is a pain or discomfort in the chest or adjacent areas caused by ischemia or lack of blood supply which causes a lack of oxygen to the heart. Angina symptoms are usually improved with treatment. It can be caused by a blood clot that has formed due to the plaque of atherosclerosis.