Second Line Drugs Second line refers to drugs used usually in adjunct to the first line drugs. Effective against drop attacks, myoclonic, partial seizures and absences, but tolerance often develops. Behavioural disturbance, including aggression and depression, are the most significant side effects. Average daily dose range 10-30mg in divided doses. Effective against drop attacks, generalised tonic-clonic and partial seizures, but tolerance often develops.
Depression is rare.
Weight gain can occur. As prescribed by the doctor. Usually reserved for intermittent and emergency use. Drowsiness, ataxia, poor co-ordination and double vision. Primidone is partly metabolised to Phenobarbitone in the body.