These results suggests that one of the ways tricyclic drugs exert antidepressive effects is by raising SAM levels. SAM's benefits in these conditions probably stem from a combination of its effects on brain chemistry and liver function. Fibromyalgia Fibromyalgia is a recently recognized disorder which is regarded as a common cause of chronic musculoskeletal pain and fatigue. The likelihood of being diagnosed as having fibromyalgia or CFS depends on the type of physician consulted. Specifically, if the patient consults a rheumatologist or orthopedic specialist, he or she is much more likely to be diagnosed with fibromyalgia than CFSs.
Diagnosis requires fulfillment of all the following major criteria and four or more minor criteria.
Three clinical studies show SAM produces excellent benefits in patients suffering from fibromyalgia. The first study was a double-blind, crossover study of 17 patients with fibromyalgia. Researchers evaluated tender point score, muscle strength, disease activity, subjective symptoms, mood parameters, and side effects. SAM was without side effects. Migraine SAM is beneficial in the treatment of migraine headaches.