The division embodies a multi-disciplinary research group, in which the molecular neurobiology is studied in an integrated approach from gene to behaviour. Our research is embedded in a national network in the neurosciences and in endocrinology. The more molecular approach in Amsterdam and the biochemical cellular approach in Leiden, combined with the facilities to in vivo experiments in both places, enable the desired integrated assessment of toxicity mechanisms. Next to studies of the molecular and cellular mechanisms of toxicity, this theme includes investigations into possible applications of the acquired knowledge in various important toxicological areas. The research focuses on drug and gene targeting to specific liver cells type, tumors and the vascular wall.
Carriers are lipoproteins, recombinant chylomicrons and liposomes.
As recognition markers triantennary galactosides, mannosides and apolipoprotein E are used. The applied drugs include antisense oligonucleotides, antiviral drugs and cytostatics. Technology is developed to allow proper packaging of genes in order to induce specific cellular delivery for gene therapy and gene repair. Our research is directed towards an understanding of the integrated biological system in vivo , combining fundamental research on the regulation of blood-brain barrier homeostasis with investigations on the relationships between receptor expression and pharmacological response. We have an emerging interest in the design of novel therapeutic strategies based on drug combinations.