Since then, the 900 kDa structure of the toxin has been elucidated. Recently, several authors have described its use in the treatment of headaches. This article will summarize its use for these conditions. Each type is antigenically distinct with its own characteristics. The neurotoxins act at the neuromuscular junction inhibiting the release of acetylcholine.
Botulinum toxin is formed as a single-chain molecule that is cleaved to form a dichain molecule.
This dichain molecule is composed of a light chain linked by a disulfide bond to a heavy chain. Four steps are required in the cellular action of this neurotoxin 3 . Botulinum Toxin Mechanism Of Action. The Botox light chains block specific proteins, which are used in binding the Acetylcholine vesicle to the cell membrane. The heavy chain of the toxin enables binding of the toxin to the presynaptic terminal through high-affinity acceptors that are specific for the various distinct serotypes.