When using the infrequent dosing method for aminoglycosides, measurement of peak and trough levels are unnecessary and should be discouraged because peak levels should always be adequately high, and trough concentrations will usually be immeasurably low. Instead, a nomogram has been designed to evaluate the appropriateness of the initially selected interval using a single drug level obtained 8-12 hours after the infusion. Single drug levels are recommended after the initial dose and then every 4-7 days throughout the course of therapy. A card with this dosing information and nomogram is available through the Department of Pharmacy. Once-daily aminoglycoside therapy.
Aminoglycoside dosage regimens.