Traditional guidelines indicate 10 seconds as the maximum response time before users lose interest. On the web, users have been trained to endure so much suffering that it may be acceptable to increase this limit to 15 seconds for a few pages. If most big Web sites do something in a certain way, then follow along since users will expect things to work the same on your site. Stay away from frames unless absolutely necessary. Users still cannot bookmark pages correctly in Netscape and older versions of Internet Explorer.
Correct printing can also be a problem for certain users.
Provide strong navigational support . Start your design with a good understanding of the structure of the information space and communicate this structure explicitly to the user. Provide a site map and let users know where they are and where they can go. Also, you will need a good search feature since even the best navigation support will never be enough. Your best model for design success is to test early and often with a diverse group of users.