Robert G. Parton and Kai Simons. Stringent sorting mechanisms recruits certain transmembrane proteins into pits of the plasma membrane defined by their coats of clathrin. Concentration of proteins generates heterogeneity within the plane of the membrane. Maintenance determined by biophysical properties of lipids rather than protein-protein interactions. Insolubility of detergent-insoluble complexes is a property of the lipids, especially sphingomyelin, which may form the basic insoluble core to which other components such as cholesterol would interact.
DIGs differ from caveolae in that caveolae are invaginated and ready to be internalized.
Bacterial spelunkers . M.A. Mulvey and S.J. Hultgren. Shin et al. The caveolae encapsulate and internalize the E. coli.