The two drugs often are compared to each other because they produce similar mood-altering effects and both have a high potential for abuse and dependence. Methamphetamine and cocaine also share other similarities. However, the two drugs also exhibit significant differences. Here are some of these similarities and differences. Sources Methamphetamine is man-made.
Cocaine is plant-derived.
Both methamphetamine and cocaine are commonly smoked, injected intravenously, or snorted. Methamphetamine also is commonly ingested orally. Geographic Patterns of Use Methamphetamine use is highest in Honolulu, Hawaii, and western areas of the continental United States, particularly urban areas of California, Washington, Oregon, Colorado, and Arizona. In recent years, methamphetamine use has increased in both rural and urban areas of the South and Midwest. Cocaine use also is significantly higher in large metropolitan areas than in nonmetropolitan areas.