Changes in You Depression during Pregnancy Antidepressant medication is not generally given during pregnancy because it is not considered safe. Recent studies indicate Prozac is safe to use during pregnancy. Most evidence indicates there is no rate of increased malformations if these medications must be used during pregnancy. There is little information about the use or safety in pregnancy of some of the newer medications for depression. Without some evidence they are safe, physicians hesitate to prescribe them.
All antidepressant medications pass through the placenta to the baby.
If these medications must be used during pregnancy, it's best to use the lowest dosage possible. Treating depression during pregnancy can be a difficult problem and must be done on an individualized basis. Your doctor and possibly a psychologist or psychiatrist may be involved in your treatment. Discuss medications you take for depression with your doctor. An infant born to a mother who takes antidepressants during pregnancy may have withdrawal symptoms.