Recently, our laboratory has developed a human tissue target angiogenesis assay with high throughput capacity. Current research directions include the regulation of growth factor and growth factor receptor expression by somatostatin-like peptides. The long-term goal of these studies is to improve our understanding of the basic mechanisms involved with somatostatin induced inhibition of angiogenesis and to be able to develop a pharmacologic intervention for use in retinopathy and tumor models. Multiply radioiodinated somatostatin analogs induce receptor-specific cytotoxicity. Journal of Surgical Research.
Breast cancer increases initiation of angiogenesis without accelerating neovessel growth rate.
Retinal toxicity of intravitreous octreotide in the rabbit. Canadian Journal of Ophthalmology. Calcium reverses octreotide inhibition of insulin and glucagon levels in patients with insulinoma and glucagonoma.