Of all the sources of transmission, this is the most likely to spread disease. Frequent hand washing is the best defense. Seeing CDAD Current understanding of the pathogenesis of CDAD is that C. difficile is an exogenously acquired pathogen, similar to any other enteric pathogen. Not everyone gets CDAD, although they may have acquired C. difficile bacteria. Conditions are ripe for CDAD when an outside influence predisposes the intestine to C. difficile .
Antibiotics are the typical cause, but chemotherapy and abdominal surgery can also act as catalysts.
Surgical patients who receive antibiotics are at particular risk. Among antibiotics, the most common culprits include clindamycin, ampicillin, amoxicillin, and the cephalosporins. B. These toxins damage the mucosal lining, leading to colon inflammation, diarrhea, and other symptoms. In PMC, numerous whitish yellow lesions, or plaques, measuring up to 1 cm merge and slough off, leaving large denuded areas. Ultimately, PMC can lead to toxic megacolon, hemorrhage, bowel perforation, hypovolemic shock, and death.