For general employee populations, acronyms should be avoided. B2B should be limited to email, where shorthands are common, or to rock music groups. Too jargony for me to choose. Minimize their use. C. Let everyone know what you are talking about.
Clarity is paramount.
Use jargon only when it's appropriate to your audience, and then use it sparingly. B2B is not a term we use in our writing, so it generally isn't a challenge.