The pancreatic ducts get blocked with thickened exocrine secretions, and reduced levels of the pancreatic digestive enzymes arrive in the intestine. Digestion of dietary proteins is therefore be inhibited. Absorption of these amino acids is reduced, but the clinical problems generally come from reaborption from the kidney. Cystinuria is one of the most common genetic diseases affecting 1 in 7000 people. It causes the precipitation of cystine to form kidney stones, blocking the urinary tract.
Cystine is the least soluble amino acid.
Patients generally present in 20s, 30s, 40s with urin ary tract stones. Diagnosed by high levels of urinary cysteine, ornithine, arginine, and lysine. Often can be treated by increased fluid intake. Marasmus results from overall poor diet, including lack of good protein. Certain types of grain are poor sources of tryptophan and lysine.