Primary refractory myeloma. Progression, with worsening symptoms and a rising M-protein, while receiving initial chemotherapy. These patients require some form of alternate therapy. Relapsing refractory myeloma. These patients respond initially, but have now relapsed and are refractory to previously effective therapy.
Alternate therapy is required.
Alternate treatment for refractory myeloma 1. Stable, asymptomatic, 'refractory' myeloma. Primary and relapsing refractory myeloma. Patients with refractory myeloma are good candidates for trials of promising new agents, or new approaches to treatment. This schedule is well tolerated.