This work was accepted by the American Federation of Medical Research and published in their very renowned top journal, formerly Clin Res . Leukocyte migration plays a tremendous role during inflammation.
Different drugs are able to influence migration of leukocytes.
Several authors have attempted to establish methods for investigation of leukocyte migration. Migration of leukocytes under conditions simulating natural blood flow and shear stress is poorly understood. The aim of the current study was to create a new three-dimensional assay investigating migration during simulated perfusion. The assay was used for investigating the effect of meloxicam on leukocyte migration under shear stress. This new system allows inclusion of SMC-layers.