Specifically, the large arteries of the lower leg can become calcified and or clogged. Rapidly spreading infection in skin is called cellulitis.
Abscess can also develop under the skin.
While these are usually associated with long standing wounds or ulcers, even small scrapes or cracks in the skin can lead to severe infection when inadequate blood flow is present. The foot of diabetics may become very dry and the skin may peel and crack since the nerves that control sweating in foot does not work. After bathing, one must dry their feet, and seal in the moisture that remains with a thin coat of a lubricant. Plain petroleum jelly, unscented hand creams, or other such products are sufficient. Oil or cream must not be applied between the toes.