Uveal or vitreous deposit. Involvement of posterior segment of the eye. May antedate clinical CNS involvement. Patients with documented CNS-NHL may later develop uveal involvement. Present with cloudy, blurred vision, decreased visual acuity.
Diagnosis is by slit lamp exam.
The need exclude systemic disease is debated but most institutions will perform staging investigations. Screening for systemic lymphoma is controversial. However the need for systemic screening should be individualized. For example, all patients with meningeal involvement should probably undergo a thorough search for systemic lymphoma. Staging includes complete examination, bloodwork, bone marrow aspirate, CXR, chest and abdominal CT, and probably an HIV test.