John Dempsey Hospital and Connecticut Children's Medical Center is a federally funded treatment center specializing in the care of patients with bleeding or clotting disorders.
Affected individuals can have spontaneous muscle or joint bleeding or bleeding at other sites.
The clinical severity is dependent upon the residual amount of blood clotting factor in the blood. Individuals with the most severe disorder have complete absence of either factor VIII or IX in the blood. Individuals with less severe disease have levels greater than zero but below the normal range. Daughters of affected males will be carriers but the sons of affected males will be unaffected. These latter products are not derived from human plasma but rely on the ability of cells in culture to make factor VIII or factor IX after the gene for these proteins has been inserted into the cells.