Cytoskeletal proteins and organelles dynamically relocalize within living cells during cytokinesis, motility, and phagocytosis . In addition, novel components of the cytoskeletal, including coronin, cortellexin, and scar having been discovered in Dictyostelium.
Conventional myosin is required for cytokinesis .
Chemoattractants are sensed by G-protein coupled receptors . Gradient direction is sensed by selectively recruiting PH domains to the membrane. Neither surface receptors nor G-proteins are significantly clustered at the cell s leading edge. Many of these observations have recently been duplicated in mammalian leukocytes responding to chemokines. A number of genes and signaling pathways found in higher eucaryotes but not in yeast predate metazoans .