This corresponding array of genes on chromosomes is an important reason why mice have served as excellent models of human deafness in laboratory research. The mutant gene in the shaker mouse was mapped to mouse chromosome 7, a place that corresponds to a part of the human chromosome 11. Usher syndrome type 1B had already been mapped to this region in family studies. The exact gene then was searched for in these family members using the information learned in animal research. The search was successful, and the human gene was mapped.
Conventional myosin is found in muscle and is the essence of muscle contraction.
This unconventional myosin molecule found in the ear binds to one of the proteins in the cochlea, and provides movement in the innards of the cells of the hearing organ. We know that the firing mechanism in hair cells requires molecular movement to open ion channels. We don't know the details, though. Those open channels of firing hair cells let the chemical electricity of charged ions flow, and allow our minds to hear. Understanding more may help treat Usher syndrome, and maybe even find medicines that improve the sensitivity of the ear.