Tolterodine may be taken without regard to meals. Tolterodine is contraindicated in patients with urinary retention, gastric retention, or uncontrolled narrow angle glaucoma. Tolterodine is contraindicated in patients with known hypersensitivity to any ingredient of the product. Safety evaluations showed no statistically significant difference between older and younger patients and no dosage adjustment appears necessary. The effects of renal insufficiency on the pharmacokinetics of tolterodine have not been established.
Caution is advised when using tolterodine in patients with significant renal impairment.
Tolterodine is extensively metabolized by the liver following oral administration. The clearance of tolterodine in cirrhotic patients is significantly decreased. Patients with significant hepatic insufficiency should not receive doses of tolterodine greater than 1 mg twice a day. Safety and effectiveness have not been established. The effects of tolterodine on the human fetus have not been evaluated.