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Children are more likely to have swollen nodes than are adults.
In children, the problem is usually a sign of infection. When older people develop the condition, there may be a more serious underlying cause. Causes Lymphadenopathy is usually caused by a viral or bacterial infection. When you're fighting an infection, nearby lymph nodes get bigger and become tender. But, with an infection, they can swell to 2 or 3 times their usual size.