Information obtained from simplified, primary cultures of rodent neurons is being compared to information obtained in the highly complex, intact system as well as in a system of intermediate complexity, the brain slice. An immortalized cerebellar cell culture system can be induced to display mature neuronal characteristics. Holliday, J., Parsons, K., Curry, J., Lee, S.Y. and D.L. Gruol, 1995. Cerebellar granule neurons develop elevated calcium responses when treated with interleukin-6 in culture. Holliday, J. and N.C. Spitzer, 1993.
Calcium regulates neuronal differentiation both directly and via co-cultured myocytes.
N.C. Spitzer, 1991. Calcium-induced release of calcium regulates differentiation of spinal neurons. Holliday, J. and N.C. Spitzer, 1990. Spontaneous calcium influx and its roles in differentiation of spinal neurons in culture. For questions or suggestions concerning the content of these pages, contact the URMC Webmaster .