A good example of this unpredictable sequence of dissociation of cells and hormones is equilin, one of the ingredients found in horse estrogen or Premarin, as it is called. As illustrated, the structures of natural estrogens replicate that of Premarin, but subtle differences in structure differentiate their characteristics in the body even more than the similarities which help produce their estrogenic effects.
Differences are subtle yet express their empact ever so demonstrably.
Alterations are slight but it must be remembered that the synthetic analogues have been altered so that their metabolism stops at a certain point. They cannot be turned off by the target receptors and, because they remain active for so long, the complications become more profound. When comparing the natural plant-derived testosterone to the commonly used methyl variety, you find the natural hormone gets the same reliable therapeutic benefits against congestive heart disease, ischemic cardiomyopathy and athersclerosis without the delayed, residual effects left by the synthetic hormones. For reliability, effectiveness, and sensitivity to the host, the plant sterols stand as the only reliable choice. Based on the dark side witnessed in 15 years of study in this area, the viable alternative to synthetic administration is the biologically-acceptable form of natural endocrine support.