For obvious reasons, the sensory organs containing the transducers cells are located at or near the surface of the body in all animals, including humans. When we apply this universal rule of nature about informational input into the brain to claims for telepathy, we come up short on all accounts. Nor, contrary to popular myth, is there any large area of the brain whose function is unknown, and which might be responsible for reception and interpretation of signals from the hypothetical ESP organ. The ability to sense the presence of predatory animals that could not have been seen, heard, or smelled would confer such enormous advantages for its possessors that evolution should have made ESP as common as fur, claws, and moist noses. It has not happened.
Comparative anatomy fails to show any evidence for the former contention.
There is no information concerning the second notion. A proponent of ESP could argue that telepathy differs from all other senses in that the brain itself is the telepathic sense organ. This brings us to the realm of physics, where ESP falls down as badly as in the realm of physiology. All interactions between one bit of matter and another can be understood and precisely described in terms of just these four forces. Because these are now well understood, we know none of them could be responsible for the hypothetical ESP stimuli.