The more successful they are in maintaining normal glucose levels, the less tissue damage will ensue and the better will be the long term prognosis The major pathophysiological change in Type 2 diabetes is insulin resistance. There is an associated phenomenon called Syndrome X which is capturing a lot of attention. People with Syndrome X are at increased risk for heart disease. Execs insulin itself seems to accelerate atherosclerosis. Interestingly enough, woman with polycystic ovary disease are often found to be insulin resistant.
Acanthosis is a velvety hyperpigmented rash found on the nape of the neck or axillae.
They are useful, therefore, in the treatment of Type 2 diabetes as well as Syndrome X . Clinically Because Type 1 diabetes is due to destruction of the beta cells resulting in an inability to produce insulin, Type 1 diabetics have no choice except to be treated with insulin. Type 2 diabetics, on the other hand, have functioning beta cells that can produce insulin. There problem, mostly, is insulin resistance. Insulin resistance can be overcome by increasing the level of insulin already present or by improving the effectiveness of insulin at the tissue level.