Because of the vasoocclusive effect of mucormycosis, the involved tissue rarely bleeds, so debridement until normal, well-perfused, bleeding tissue is encountered is ideal. Surgery often may be disfiguring. Orbital exenteration, along with removal of sinuses, may be necessary. Consider reconstructive surgery only after complete resolution of infection. A multidisciplinary approach is the best.
Control diabetes if it is an underlying disease.
Although aggressive surgical intervention is required, patients also should receive adjuvant antifungal therapy. Antifungals - Their mechanism of action may involve an alteration of RNA and DNA metabolism or an intracellular accumulation of peroxide that is toxic to the fungal cell. Drug resistant species of have been isolated in patients receiving prolonged therapy. Serial imaging and evaluation is preformed as needed to assess the extent of the disease and to decide if reoperation is necessary. After amphotericin B is discontinued, close assessment for recurrence needs to be performed.