One study reported that it may be helpful for children with periodic limb movement and symptoms of attention-deficit hyperactivity disorder. All have potentially severe side effects and should be tried only after non-drug methods have failed. Studies indicate it had only a slight benefit and some serious, although rare, side effects had been reported, including bleeding problems and heart irregularities. Other, less serious side effects include headaches, vision problems, and rash. Other drugs tried for leg cramps without much success include vitamin E and potassium chloride.
Calcium supplements help relieve leg cramps in pregnant women.
Experts advise nightly stretching exercises as the best preventive measures for leg cramps. While in bed, loose covers should be used to prevent pointing the toes, which causes calf muscles to contract and cramp. Propping the feet up higher than the torso may help. Once a cramp begins, the patient should straighten the leg, flex the foot up or grab the toes and pull forward. Restless Legs Syndrome .