Research conducted in part by VBWG faculty. Screening for microalbuminuria should be considered because of its link to all-cause and cardiovascular mortality. 2001 Genetic deficiency of CD44 leads to marked reduction in atherosclerosis in apoE-deficient mice. CD44 appears to promote atherogenesis through multiple mechanisms, including macrophage recruitment to atherosclerotic lesions and vascular cell activation. However, adjustment for age and history of cardiovascular disease eliminated this difference.
Data suggest that HOCl induces endothelial dysfunction via modification of L-arginine.
2001 Data from animal models suggest that bradykinin may be involved in neointimal proliferation during restenosis. Dipyridamole in chronic stable angina patients. The Nucleotide Axis Hypothesis is proposed. It states that ATP stimulates release of vasoactive mediators from the endothelium. Altered NO-dependent vasorelaxation in heart failure appears to be due to excessive degradation of NO related to reduced activity of vascular superoxide dismutase.